bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of virtual reality on creativity performance and perceived immersion: A study of brain waves
Authors: Wang Yen‐Yin , Weng Tz‐Han , Tsai I‐Fan , Kao Jing‐Yueh , Chang Yu‐Shan 
Published: August 2022

AbstractThe purpose of this study was to explore the effects of virtual reality (VR) application on creative performance and immersion, evaluated through electroencephalography brain wave data to achieve accurate and robust results. In this study, 72 middle school teachers were recruited as participants, and a non‐randomized control‐group pre‐test–post‐test design was employed. The experimental group received VR‐based design instruction, and the control group received lecture‐based design training. Our results revealed that VR significantly affects immersion, especially with regard to attention. Additionally, VR had a positive effect on the feasibility of the creative process, although its effects on variety and novelty were inconclusive. VR was significantly correlated with theta, beta, and gamma brain wave activity. VR also increased attention‐related and meditation‐related brain wave activity and desynchronized alpha waves.Practitioner notesWhat is already known about this topic

VR is used in many areas.
VR in education is getting more important day after day.
What this paper adds

VR significantly affects immersion, especially with regard to attention.
VR had a positive effect on the feasibility of the creative process, although its effects on variety and novelty were inconclusive.
VR was significantly correlated with theta, beta, and gamma brain wave activity.
VR also increased attention‐related and meditation‐related brain wave activity and desynchronized alpha waves.
Implications for practice and/or policy

User lack of familiarity with VR may also have influenced the results; more VR learning materials should be provided for learners.
In addition to using a larger sample, future studies should focus on creative novelty when developing VR content to improve creative processes and outcomes.
Familiarizing learners with the use of VR could effectively reduce the cognitive load, as well as contribute to the stimulation of creative brain waves.
Community attachment, job loss and regional labour mobility in Canada: Evidence from the Great Recession
Authors: Messacar Derek 
Published: August 2022

AbstractLabour mobility is an important mechanism to equilibrate regional differences in labour market conditions. Yet, little is known about underlying differences between individuals that explain why some stay in place during times of economic hardship while others in objectively similar situations choose to leave. Using a novel dataset comprising 59,974 respondents of a national community health survey from Canada linked to their administrative tax records, this paper provides new insights into this important issue. Specifically, I investigate the extent to which individuals' objective and subjective ties to their local communities mitigate or exacerbate the decision to relocate following an exogenous job separation. To credibly identify this effect, I exploit variation in regional employment conditions over time caused by construction industry shocks during the Great Recession, based on an instrumental variables approach. The results indicate that job loss increases the likelihood of migrating within the same province by approximately 1.4 to 2.3 percentage points among men. Moreover, this effect is driven primarily by individuals with low sense of community belonging, which indicates “push and pull” between the need to relocate for work and the desire to stay near family and friends.
Silencing of OGDHL promotes liver cancer metastasis by enhancing hypoxia inducible factor 1 α protein stability
Authors: Dai Weiqi , Li Yueyue , Sun Weijie , Ji Meng , Bao Renjun , Chen Jianqing , Xu Shuqi , Dai Ying , Chen Yiming , Liu Wenjing , Ge Chao , Sun Wei , Mo Wenhui , Guo Chuanyong , Xu Xuanfu 
Published: August 2022

AbstractHepatocellular carcinoma (HCC) is one of the most common malignant diseases associated with a high rate of mortality. Frequent intrahepatic spread, extrahepatic metastasis, and tumor invasiveness are the main factors responsible for the poor prognosis of patients with HCC. Hypoxia‐inducible factor 1 (HIF‐1) has been verified to play a critical role in the metastasis of HCC. HIFs are also known to be modulated by small molecular metabolites, thus highlighting the need to understand the complexity of their cellular regulation in tumor metastasis. In this study, lower expression levels of oxoglutarate dehydrogenase‐like (OGDHL) were strongly correlated with aggressive clinicopathologic characteristics, such as metastasis and invasion in three independent cohorts featuring a total of 281 postoperative HCC patients. The aberrant expression of OGDHL reduced cell invasiveness and migration in vitro and HCC metastasis in vivo, whereas the silencing of OGDHL promoted these processes in HCC cells. The pro‐metastatic role of OGDHL downregulation is most likely attributed to its upregulation of HIF‐1α transactivation activity and the protein stabilization by promoting the accumulation of L‐2‐HG to prevent the activity of HIF‐1α prolyl hydroxylases, which subsequently causes an epithelial–mesenchymal transition process in HCC cells. These results demonstrate that OGDHL is a dominant factor that modulates the metastasis of HCC.
Induction of potent antitumor immunity by intradermal DNA injection using a novel needle‐free pyro‐drive jet injector
Authors: Inoue Shinya , Mizoguchi Izuru , Sonoda Jukito , Sakamoto Eri , Katahira Yasuhiro , Hasegawa Hideaki , Watanabe Aruma , Furusaka Yuma , Xu Mingli , Yoneto Toshihiko , Sakaguchi Naoki , Terai Kazuhiro , Yamashita Kunihiko , Yoshimoto Takayuki 
Published: August 2022

AbstractThe current success of mRNA vaccines against COVID‐19 has highlighted the effectiveness of mRNA and DNA vaccinations. Recently, we demonstrated that a novel needle‐free pyro‐drive jet injector (PJI) effectively delivers plasmid DNA into the skin, resulting in protein expression higher than that achieved with a needle syringe. Here, we used ovalbumin (OVA) as a model antigen to investigate the potential of the PJI for vaccination against cancers. Intradermal injection of OVA‐expression plasmid DNA into mice using the PJI, but not a needle syringe, rapidly and greatly augmented OVA‐specific CD8+ T‐cell expansion in lymph node cells. Increased mRNA expression of both interferon‐γ and interleukin‐4 and an enhanced proliferative response of OVA‐specific CD8+ T cells, with fewer CD4+ T cells, were also observed. OVA‐specific in vivo killing of the target cells and OVA‐specific antibody production of both the IgG2a and IgG1 antibody subclasses were greatly augmented. Intradermal injection of OVA‐expression plasmid DNA using the PJI showed stronger prophylactic and therapeutic effects against the progression of transplantable OVA‐expressing E.G7‐OVA tumor cells. Even compared with the most frequently used adjuvants, complete Freund's adjuvant and aluminum hydroxide with OVA protein, intradermal injection of OVA‐expression plasmid DNA using the PJI showed a stronger CTL‐dependent prophylactic effect. These results suggest that the novel needle‐free PJI is a promising tool for DNA vaccination, inducing both a prophylactic and a therapeutic effect against cancers, because of prompt and strong generation of OVA‐specific CTLs and subsequently enhanced production of both the IgG2a and IgG1 antibody subclasses.
Genetic disorders of thyroid development, hormone biosynthesis and signalling
Authors: Moran Carla , Schoenmakers Nadia , Visser W. Edward , Schoenmakers Erik , Agostini Maura , Chatterjee Krishna 
Published: August 2022

AbstractDevelopment and differentiation of the thyroid gland is directed by expression of specific transcription factors in the thyroid follicular cell which mediates hormone biosynthesis. Membrane transporters are rate‐limiting for cellular entry of thyroid hormones (TH) (T4 and T3) into some tissues, with selenocysteine‐containing, deiodinase enzymes (DIO1 and DIO2) converting T4 to the biologically active hormone T3. TH regulate expression of target genes via hormone‐inducible nuclear receptors (TRα and TRβ) to exert their physiological effects. Primary congenital hypothyroidism (CH) due to thyroid dysgenesis may be mediated by defects in thyroid transcription factors or impaired thyroid stimulating hormone receptor function. Dyshormonogenic CH is usually due to mutations in genes mediating thyroidal iodide transport, organification or iodotyrosine synthesis and recycling. Disorders of TH signalling encompass conditions due to defects in membrane TH transporters, impaired hormone metabolism due to deficiency of deiodinases and syndromes of Resistance to thyroid hormone due to pathogenic variants in either TRα or TRβ. Here, we review the genetic basis, pathogenesis and clinical features of congenital, dysgenetic or dyshormonogenic hypothyroidism and disorders of TH transport, metabolism and action.
Diagnosis and therapy of Mycobacterium marinum: a single‐center 21‐year retrospective analysis
Authors: Strobel Katharina , Sickenberger Christina , Schoen Christoph , Kneitz Hermann , Kolb‐Mäurer Annette , Goebeler Matthias 
Published: August 2022

SummaryBackground and ObjectivesIn Europe, infections with Mycobacterium (M.) marinum are rare. We conducted a retrospective single‐center study to assess the clinical spectrum of M. marinum infection and its diagnosis, treatment and outcome under real‐world conditions.Patients and MethodsEighteen patients presenting with M. marinum infections between 1998 and 2018 were identified in the data warehouse of the University Hospital Würzburg and considered for detailed analysis.ResultsTwelve patients reported aquatic exposure. In 16/18 cases the upper extremities were affected. No invasive infections were detected. Mean time to diagnosis was 15 weeks. Histology revealed granulomatous inflammation in 14 patients while mycobacterial cultures were positive for M. marinum in 16 cases. Most patients received antibiotic monotherapy (14/18) while combination therapy was administered in four cases. Treatment (with a median duration of 10 weeks) was successful in 13 patients. Five patients were lost to follow‐up.ConclusionsOur retrospective analysis of M. marinum infections at a German tertiary referral center revealed a considerable diagnostic delay and the relevance of microbiological culture, PCR and histology for diagnosis. Monotherapy with clarithromycin (rather than doxycycline) appeared as a reasonable treatment option while immunosuppressed or ‐compromised patients and those with extended disease received combination therapy.
Efficacy and safety of ultra‐rapid lispro versus lispro in children and adolescents with type 1 diabetes: The PRONTO‐Peds trial
Authors: Wadwa R. Paul , Laffel Lori M. , Franco Denise R. , Dellva Mary Anne , Knights Alastair W. , Pollom Robyn K. 
Published: August 2022

AbstractAimsTo evaluate the efficacy and safety of ultra‐rapid lispro (URLi) versus lispro in a paediatric population with type 1 diabetes (T1D) in a Phase 3, treat‐to‐target study.Materials and MethodsAfter a 4‐week lead‐in to optimize basal insulin, participants were randomized to double‐blind URLi (n = 280) or lispro (n = 298) injected 0 to 2 minutes prior to meals (mealtime), or open‐label URLi (n = 138) injected up to 20 minutes after start of meals (postmeal). Participants remained on pre‐study basal insulin (degludec, detemir or glargine). The primary endpoint was glycated haemoglobin (HbA1c) change from baseline after 26 weeks (noninferiority margin 4.4 mmol/mol [0.4%]).ResultsBoth mealtime and postmeal URLi demonstrated noninferiority to lispro for HbA1c: estimated treatment difference (ETD) for mealtime URLi −0.23 mmol/mol (95% confidence interval [CI] −1.84, 1.39) and postmeal URLi −0.17 mmol/mol (95% CI −2.15, 1.81). Mealtime URLi reduced 1‐hour postprandial glucose (PPG) daily mean (P = 0.001) and premeal to 1 hour postmeal PPG excursion daily mean (P < 0.001) versus lispro. The rate and incidence of severe, nocturnal or documented hypoglycaemia (<3.0 mmol/L [54 mg/dL]) were similar for all treatments. With mealtime URLi versus lispro, the rate of postdose hypoglycaemia (<3.0 mmol/L) was higher at ≤2 hours (P = 0.034). The incidence of treatment‐emergent adverse events was similar for all treatments. More participants reported an injection site reaction with mealtime URLi (7.9%) versus postmeal URLi (2.9%) and lispro (2.7%).ConclusionsIn children and adolescents with T1D, URLi demonstrated good glycaemic control, and noninferiority to lispro in HbA1c change for mealtime and postmeal URLi. When dosed at the beginning of meals, URLi reduced 1‐hour PPG and PPG excursions versus lispro.
Adalimumab therapy is associated with increased faecal short chain fatty acids in hidradenitis suppurativa
Authors: Tatian Artiene , Bordbar Sara , Sarkissian Samuel Der , Woods Jane A. , Cains Geoffrey D. , Chong Chun Wie , Mariño Eliana , Frew John W. 
Published: August 2022

AbstractAltered gut microbiota composition has been observed in individuals with hidradenitis suppurutiva (HS) and many other inflammatory diseases, including obesity, type 1 and type 2 diabetes. Here, we addressed whether adalimumab, a systemic anti‐inflammatory therapy, may impact the microbiota biochemical profile, particularly on beneficial metabolites such as short‐chain fatty acids (SCFAs). We conducted an observational single‐arm pilot trial to assess gut microbiota composition by 16S rRNA gene sequence analysis and to detect metabolite signatures by gas chromatography in stool samples from participants with HS prior to and 12 weeks after commencing adalimumab therapy. HS individuals that better responded to adalimumab treatment showed a shift in the composition and function of the gut microbiota with significantly increased SCFA acetate and propionate compared to age, gender and BMI‐matched healthy controls. A positive correlation was observed between propionate with Prevotella sp and Faecalibacterium prausnitsii. Increased SCFAs, changes in gut microbiota composition, function and metabolic profile following 12 weeks of adalimumab suggest that targeting SCFAs may be considered a potential biomarker to be evaluated as a complementary protective factor or as a diagnostically relevant signal in HS.
Artificial neural network and symmetric key cryptography based verification protocol for 5G enabled Internet of Things
Authors: Nyangaresi Vincent Omollo , Ahmad Musheer , Alkhayyat Ahmed , Feng Wei 
Published: August 2022

AbstractDriven by the requirements for entirely low communication latencies, high bandwidths, reliability and capacities, the Fifth Generation (5G) networks has been deployed in a number of countries. One of the most prevalent application scenarios of 5G networks is the Internet of Things (IoT) that can potentially boost convenience and energy savings. However, the information exchanged over the open wireless 5G networks is susceptible to numerous attacks such as malicious modifications. Although many protocols have been developed to protect against these attacks, the provision of optimum security and privacy issues in 5G networks is still an open challenge. This is attributed to the high device density, frequent handovers and resource constrained nature the 5G IoT nodes. In this article, a network selection and authentication protocol that securely verifies the authenticity of all the communicating entities is presented. The network selection is accomplished using Artificial Neural Network (ANN) for increased efficiency. In addition, all the security tokens are independently derived at the end devices without the involvement of any central authority. Formal security analysis based on the Burrows–Abadi–Needham (BAN) logic shows that all the terminals securely authenticate each other before the onset of packet exchanges. In addition, it is shown that this protocol thwarts majority of the conventional 5G attack vectors and is robust under the Dolev–Yao (DY) threat model. Moreover, a comparison with other related schemes shows that the proposed protocol offers many adorable security features at relatively low communication and computation costs. The simulation results show that the deployed ANN yields low packet loss ratio and latency variations.
God and God’s beloved: A constructive re‐reading of Scotus’s supralapsarian Christological argument
Authors: van Driel Edwin Chr 
Published: August 2022

AbstractIn this essay I argue that John Duns Scotus offers two arguments to support his well‐known supralapsarian Christological position: a formal argument based on the ordering within God’s will, and a material argument based on the ordering of God’s love. While the latter is constructively more fruitful, its most natural reading, according to which God becomes incarnate so as to be loved not just by Godself but also by another, is also inconsistent with Scotus’s own account of the metaphysics of the incarnation. An alternative reading, according to which God hypostatically unites with the human soul of Christ because God falls in love with it, is equally untenable. I offer therefore an alternative reading that, while not consistent with the letter of Scotus’s argument, I believe nonetheless to be consistent with its spirit. On this reading, the love expressed in the incarnation is directed at creation. In deciding to become incarnate, God decides to give Godself to that what is not God; the embodiment of this decision is Christ. The incarnation is not an expression of divine self‐love, or love for one particular soul, but an expression of love for others.
Thermal processes improving antibrowning potential of mixed Aloe vera and pineapple core extract solution on browning inhibition of fresh‐cut apples
Authors: Takeungwongtrakul Sirima , Sai‐Ut Samart , Waraput Thidarat , Supapvanich Suriyan 
Published: August 2022

SummaryAloe vera and pineapple fruit extract have been applied as natural antibrowning agent for fresh‐cut products. The effect of different thermal treatment processes (high‐temperature–short‐time pasteurisation at 80 ± 1 °C for 15 s and sterilisation at 121 ± 1 °C for 20 min) of mixed A. vera and pineapple core extract solution at a ratio of 1:1 (v/v) (AP) on enzymatic browning control of fresh‐cut ‘Gala’ apples was investigated. Both thermal processes increased the antioxidant activities of AP solution compared to unheated AP solution. Coating of both thermal processed AP solutions alleviated the increased browning incidence of the fresh‐cut apples during storage. Compared to sterilised AP coating, the pasteurised AP coating maintained visual appearance, whiteness index (WI) and L* values as well as inhibited browning incidence due to the prevention of increased a*, b*, ΔE* and browning index (BI) values of fresh‐cut apples during storage. The fresh‐cut apples coated with pasteurised AP had lower total phenolic compounds and polyphenol oxidase activity compared to the samples coated with sterilised AP. These suggested that the suitable thermal process was helpful to enhance antibrowning ability of AP coating agents to control enzymatic browning reaction of fresh‐cut fruits.
Chitosan and gelatine biopolymer‐based active/biodegradable packaging for the preservation of fish and fishery products
Authors: Rathod Nikheel Bhojraj , Bangar Sneh Punia , Šimat Vida , Ozogul Fatih 
Published: August 2022

SummaryFish and fishery products (FFP) are considered nutraceutical foods that are believed to improve human health. FFP are highly prone to deterioration due to microorganisms, oxidation and enzymatic spoilage. Hence, packaging FFP in appropriate material has a pivotal role in shelf‐life extension. Considering the non‐degradable nature and toxicity issues associated with synthetic material, alternatives originating from natural sources have become popular. Chitosan and gelatine are known to exhibit a wide range of bioactivity making them suitable for individual and combined applications for preservation. Chitosan and gelatine films are used for the inclusion of other materials (antimicrobial and antioxidant) to form active packaging with improved properties. The active film formed using chitosan and gelatine exhibits inactivation of microorganisms and inhibits oxidation activity. This review describes the recent knowledge on the development and characterisation of active packaging material by using chitosan and gelatine as well as the application of chitosan and gelatine‐based active films for the preservation of FFP to extend the shelf‐life.
Utilisation of Kinnow peel as a functional ingredient in bread: Physicochemical, functional, textural and sensory attributes
Authors: Kaur Simranjeet , Sachdev Poonam Aggarwal , Singh Arashdeep , Surasani Vijay Kumar Reddy 
Published: August 2022

SummaryKinnow peel, a major by‐product (30%–34%) of Kinnow processing, is a rich source of dietary phytochemicals, and possesses biochemical and pharmacological properties with positive health benefits. The present study used kinnow peel powder (KPP) at 0%, 1%, 2% & 3% (on flour basis) as a functional ingredient and observed its effect on functional, baking, textural, antioxidant and sensory properties of bread. KPP significantly (P < 0.05) reduced the final viscosity of blends, while increased the bake absorption (60.10%–67.01%) and reduced the bake loss (14.30–11.16 g) of bread. Higher moisture binding and fibre content of KPP also hinders the leavening capacity of the bread as a result of which loaf‐specific volume decreased progressively, while increasing the bread crumb hardness (5.41–9.39 N). The presence of bioactive compounds in KPP increased the total phenolic (16.93–45.21 mg GAE 100 g−1), flavoniods (4.71–42.53 mg QE 100 g−1), carotenoid content (2.90–6.71 mg 100 g−1) of bread and enhance its antioxidant activities. Bread crumb with KPP exhibits increased lightness and yellowness value. Bread with 2% KPP presented better sensory properties that can be used to prepare acceptable bread. Principal component analysis also revealed bread with 2% KPP with better functional attributes.
High‐pressure homogenisation—Lactobacillus induced changes in the properties and structure of soymilk protein gels
Authors: Sun Bingyu , Li Zhimin , Huang Yuyang , Liu Linlin , Gu XueLian , Gao Yuan , Zhu Xiuqing , Zhu Ying , Xia Xiaoyu 
Published: August 2022

SummaryIn this study, we investigated the effects of high‐pressure homogenisation (HPH) combined withLactobacillus(LAC) induction (43 °C and 8 h) on the gel properties and structure of soymilk protein under different pressures (0,100,110,120,130 and 140 MPa). HPH significantly improved the fermentation rate and gel characteristics of the soymilk. The soybean protein treated at 120 MPa had the best gel characteristics, with shorter gel formation time, higher water‐holding capacity and stronger hardness and viscosity. Particle size and protein structure analyses confirmed that the particle size of soy protein was smaller and the protein was more folded at a homogenising pressure of 120 MPa. HPH accelerated the unfolding of protein structure and exposure of hydrophobic groups, facilitating the interaction between LAC and proteins, thereby accelerating the formation of macromolecular aggregates in gels and improving the gelation properties of soy protein. This work established the application prospect of HPH in dairy processing and soybean‐based fermentation product development.