bluuebunny/crossref_metadata_2025_split huggingface dataset:
J/ψ polarization in semi-inclusive DIS at low and high transverse momentum
Authors: D’Alesio Umberto , Maxia Luca , Murgia Francesco , Pisano Cristian , Rajesh Sangem 
Published: March 2022

Abstract
We study the polar and azimuthal decay angular distributions of J/ψ mesons produced in semi-inclusive, deep-inelastic electron-proton scattering. For the description of the quarkonium formation mechanism, we adopt the framework of nonrelativistic QCD, with the inclusion of the intermediate color-octet channels that are suppressed at most by a factor v4 in the velocity parameter v relative to the leading color-singlet channel. We put forward factorized expressions for the helicity structure functions in terms of transverse momentum dependent gluon distributions and shape functions, which are valid when the J/ψ transverse momentum is small with respect to the hard scale of the process. By requiring that such expressions correctly match with the collinear factorization results at high transverse momentum, we determine the perturbative tails of the shape functions and find them to be independent of the J/ψ polarization. In particular, we focus on the cos 2ϕ azimuthal decay asymmetry, which originates from the distribution of linearly polarized gluons inside an unpolarized proton. We therefore suggest a novel experiment for the extraction of this so-far unknown parton density that could be performed, in principle, at the future Electron-Ion Collider.
High quality axion via a doubly composite dynamics
Authors: Lee Seung J. , Nakai Yuichiro , Suzuki Motoo 
Published: March 2022

Abstract
We explore a new framework that furnishes a mechanism to simultaneously address the electroweak naturalness problem and the axion high quality problem. The framework is based on a doubly composite dynamics where the second confinement takes place after the CFT encounters the first confinement and the theory flows into another conformal fixed point. For a calculable example, we present a holographic dual description of the 4D model via a warped extra dimension model with three 3-branes. While the hierarchy problem is taken cared of by the localization of the Higgs fields on the TeV brane just as in the original Randall-Sundrum model, the Peccei-Quinn (PQ) symmetry is realized as a gauge symmetry in the bulk of the extra dimension to solve the axion quality problem. We introduce a 5D scalar field whose potential at the intermediate brane drives spontaneous breaking of the PQ symmetry. Then, the PQ breaking scale is given by the scale of the intermediate brane and is naturally small compared to the Planck scale. The axion bulk profile is significantly suppressed around the UV brane, which protects the axion from gravitational violations of the PQ symmetry on the UV brane. Our model genuinely predicts the existence of the Kaluza-Klein excitations of the QCD axion at around the TeV scale and relatively light extra Higgs bosons.
No Page curves for the de Sitter horizon
Authors: Kames-King Joshua , Verheijden Evita M. H. , Verlinde Erik P. 
Published: March 2022

Abstract
We investigate the fine-grained entropy of the de Sitter cosmological horizon. Starting from three-dimensional pure de Sitter space, we consider a partial reduction approach, which supplies an auxiliary system acting as a heat bath both at $$ \mathcal{I} $$
I
+ and inside the static patch. This allows us to study the time-dependent entropy of radiation collected for both observers in the out-of-equilibrium Unruh-de Sitter state, analogous to black hole evaporation for a cosmological horizon. Central to our analysis in the static patch is the identification of a weakly gravitating region close to the past cosmological horizon; this is suggestive of a relation between observables at future infinity and inside the static patch. We find that in principle, while the meta-observer at $$ \mathcal{I} $$
I
+ naturally observes a pure state, the static patch observer requires the use of the island formula to reproduce a unitary Page curve. However, in practice, catastrophic backreaction occurs at the Page time, and neither observer will see unitary evaporation.
Arzneimitteltherapiesicherheit gefördert durch die interprofessionelle Zusammenarbeit von Arzt und Apotheker auf Intensivstationen in Deutschland
Authors: Hilgarth Heike , Waydhas Christian , Dörje Frank , Sommer Julia , Kluge Stefan , Ittner Karl Peter 
Published: March 2022

Zusammenfassung
Hintergrund
Kritisch kranke Patienten sind besonders anfällig für unerwünschte Arzneimittelereignisse. Internationale Studien zeigen, dass pharmazeutische Betreuung die Patienten- und Arzneimitteltherapiesicherheit positiv beeinflusst. National wird die Integration von Apothekern in das multidisziplinäre Team und eine Teilnahme an Visiten gefordert. Ziel dieser Arbeit ist es, Art und Umfang der pharmazeutischen Betreuung in der Intensivmedizin in Deutschland zu erheben.

Methode
In einer Literatur- und Datenbankrecherche wurden 13 relevante pharmazeutische Tätigkeiten identifiziert. Darauf aufbauend wurde von einem Expertengremium ein Onlinesurvey mit 27 Fragen zur Implementierung der pharmazeutischen Betreuung auf Intensivstationen erstellt. Die Umfrage wurde an Leiter deutscher Intensivstationen versandt.

Ergebnisse
Eine regelmäßige pharmazeutische Betreuung ist bei 35,3 % (59/167) der Intensivstationen etabliert. Arzneimittelinformation (89,7 % [52/58]), pharmazeutische Interventionen mit Therapieumstellung (z. B. in der Visite; 67,2 % [39/58]), regelmäßige Evaluation der Verordnung (Medikationsanalyse; 65,5 % [38/58]) sowie die Überwachung der Medikation (hinsichtlich von Nebenwirkungen, Effektivität und Kosten; 63,8 % [37/58]) zählen zu den meistgenannten Tätigkeiten. Die Teilnehmer mit pharmazeutischer Betreuung (58/168) stufen 7 von 13 Tätigkeiten als „essenziell/unverzichtbar“ ein, wohingegen es nur zwei bei den Teilnehmern ohne pharmazeutische Betreuung (104/168) sind.

Schlussfolgerung
Nur wenige Intensivstationen in Deutschland haben den Stationsapotheker bereits in das multidisziplinäre Team integriert. Ist ein pharmazeutischer Service etabliert, wird mehreren pharmazeutischen Tätigkeitsfeldern eine höhere Gewichtung/Bedeutung zugeschrieben.
Normative measurements of the superior oblique and inferior oblique muscles by magnetic resonance imaging
Authors: Rana Khizar , Juniat Valerie , Rayan Aaron , Patel Sandy , Selva Dinesh 
Published: March 2022

Abstract
Purpose
Normative oblique muscle data may help to diagnose pathological enlargement of the oblique muscles. We aim to describe the normative values of the superior and inferior oblique muscles in an Australian cohort on T1-weighted MRI and fat suppressed contrast enhanced T1-weighted MRI.

Methods
A retrospective review of patients who underwent 3 T orbital MRI. The healthy orbits were used to conduct measurements in patients with a unilateral orbital lesion. The maximum diameters of the superior and inferior oblique muscles were measured on coronal planes. The diameter was measured perpendicular to the long axis of the muscles.

Results
The normal measurements (mean ± SD) on fat suppressed contrast enhanced T1-weighted MRI: superior oblique, 3.0 ± 0.5 mm and inferior oblique, 2.7 ± 0.5 mm. On T1-weighted MRI: superior oblique, 2.8 ± 0.5 mm and inferior oblique, 2.5 ± 0.4 mm. In patients who had both sequences performed, the superior and inferior oblique diameters were significantly higher on the fat suppressed contrast-enhanced T1-weighted MRI than the T1-weighted MRI sequence (p < 0.01).

Conclusion
Oblique muscle enlargement may be seen in a range of orbital diseases. These data may help in diagnosing oblique muscle enlargement. In addition, variations in the measured muscle diameters can be seen according to the scan sequence that is used.
Breast cancer screening in women with extremely dense breasts recommendations of the European Society of Breast Imaging (EUSOBI)
Authors: Mann Ritse M. , Athanasiou Alexandra , Baltzer Pascal A. T. , Camps-Herrero Julia , Clauser Paola , Fallenberg Eva M. , Forrai Gabor , Fuchsjäger Michael H. , Helbich Thomas H. , Killburn-Toppin Fleur , Lesaru Mihai , Panizza Pietro , Pediconi Federica , Pijnappel Ruud M. , Pinker Katja , Sardanelli Francesco , Sella Tamar , Thomassin-Naggara Isabelle , Zackrisson Sophia , Gilbert Fiona J. , Kuhl Christiane K. ,   On behalf of the European Society of Breast Imaging (EUSOBI)
Published: March 2022

Abstract
Breast density is an independent risk factor for the development of breast cancer and also decreases the sensitivity of mammography for screening. Consequently, women with extremely dense breasts face an increased risk of late diagnosis of breast cancer. These women are, therefore, underserved with current mammographic screening programs. The results of recent studies reporting on contrast-enhanced breast MRI as a screening method in women with extremely dense breasts provide compelling evidence that this approach can enable an important reduction in breast cancer mortality for these women and is cost-effective. Because there is now a valid option to improve breast cancer screening, the European Society of Breast Imaging (EUSOBI) recommends that women should be informed about their breast density. EUSOBI thus calls on all providers of mammography screening to share density information with the women being screened. In light of the available evidence, in women aged 50 to 70 years with extremely dense breasts, the EUSOBI now recommends offering screening breast MRI every 2 to 4 years. The EUSOBI acknowledges that it may currently not be possible to offer breast MRI immediately and everywhere and underscores that quality assurance procedures need to be established, but urges radiological societies and policymakers to act on this now. Since the wishes and values of individual women differ, in screening the principles of shared decision-making should be embraced. In particular, women should be counselled on the benefits and risks of mammography and MRI-based screening, so that they are capable of making an informed choice about their preferred screening method.

Key Points
• The recommendations in Figure 1 summarize the key points of the manuscript
Prognostic value of cutaneous reinnervation with GAP-43 in oxaliplatin-induced neuropathy
Authors: Albayrak Merve , Figueras Carolina , Seguí Elia , Campolo Michela , Gabarrón Eva , Moreno Reinaldo , Maurel Joan , Casanova-Molla Jordi 
Published: March 2022

Abstract
Background and purpose
Oxaliplatin-induced neuropathy (OIN) implies axonal damage of both small and large sensory nerve fibers. We aimed at comparing the neurophysiological changes occurred after treatment and the capability to recovery based on histological marker of re-innervation GAP-43.

Methods
48 patients with cancer were assessed before and after chemotherapy (at 3 months and 12 months if available). We recorded ulnar and sural sensory nerve action potentials (SNAP), determined quantitative sensory thresholds for warm and cold (WDT, CDT), pain thresholds and collected a distal biopsy of skin to assess the intra-epidermal nerve fiber density (IENFD) with PGP9.5 and GAP-43 markers (in a subgroup of 19 patients).

Results
Increased WDT and CDT as well as diminished IENFD at distal leg were already found in 30% of oncologic patients before treatment. After oxaliplatin, there was a significant increase in thermal thresholds in 52% of patients, and a decrease of SNAP amplitude in the sural nerve in 67% patients. IENFD was reduced in 47% and remained unchanged in 37% after oxiplatin. The density of GAP-43 + fibers and GAP-43/PGP 9.5 ratio was similar before and after treatment showing that cutaneous re-innervation is preserved despite no clinical recovery was observed after one year.

Conclusion
Non-selective axonal loss affects sensory fibers in OIN. However, the presence of intra-epidermal regenerative sprouts detected by GAP-43 may reduce the impact of neurotoxicity in the small fibers with long-term sequelae mostly on myelinated nerve endings. Pre-oxaliplatin GAP-43 failed to identify patients with higher risk of damage or worse recovery after treatment.
Mobile AC/DC test device for electric vehicle charging infrastructure communication
Authors: Baum Lukas , Darvish Sahar , Schulz Detlef 
Published: March 2022

AbstractThe large-scale deployment of charging infrastructure poses challenges to the distribution grid stability. In Hamburg, the project Electrify Buildings for Electric Vehicles (ELBE) implements and tests a demand side management communication protocol that allows the distribution grid operator to reduce the charging power of electric vehicle charging stations if necessary. For this purpose, a test device capable of testing the signal chain as well as a real load reduction is presented for DC charging infrastructure. The standardized high-level communication protocols are described. With the charger’s power electronics located in the DC charging station, the need for a battery emulation arises, which is also discussed. Finally, a novel concept for a mobile and modular test setup for combined testing signal and real load reduction of AC and DC charging infrastructure is presented.
Weighted Error Estimates for Transient Transport Problems Discretized Using Continuous Finite Elements with Interior Penalty Stabilization on the Gradient Jumps
Authors: Burman Erik 
Published: March 2022

AbstractIn this paper we consider the semi-discretization in space of a first order scalar transport equation. For the space discretization we use standard continuous finite elements with a stabilization consisting of a penalty on the jump of the gradient over element faces. We recall some global error estimates for smooth and rough solutions and then prove a new local error estimate for the transient linear transport equation. In particular we show that for the stabilized method the effect of non-smooth features in the solution decay exponentially from the space time zone where the solution is rough so that smooth features will be transported unperturbed. Locally the L2-norm error converges with the expected order $O(h^{k+\frac 12})$
O
(

h

k
+

1

2

)
, if the exact solution is locally smooth. We then illustrate the results numerically. In particular we show the good local accuracy in the smooth zone of the stabilized method and that the standard Galerkin fails to approximate a solution that is smooth at the final time if underresolved features have been present in the solution at some time during the evolution.
Reductions in sickness with repeated exposure to HMD-based virtual reality appear to be game-specific
Authors: Palmisano Stephen , Constable Rikeya 
Published: March 2022

AbstractWhile head-mounted display (HMD) based gaming is often limited by cybersickness, research suggests that repeated exposure to virtual reality (VR) can reduce the severity of these symptoms. This study was therefore aimed at: (1) examining the exposure conditions required to reduce cybersickness during HMD VR; and (2) learning whether such reductions generalise from one HMD VR game to another. Our participants played two commercially-available HMD VR video games over two consecutive days. Their first exposure to HMD VR on both days was always to a 15-min virtual rollercoaster ride. On Day 1, half of our participants also played a virtual climbing game for 15-min, while the rest of them finished testing early. Participants in the latter group were only exposed to the climbing game late on Day 2. We found that sickness was significantly reduced for our participants on their second exposure to the virtual rollercoaster. However, sickness to the rollercoaster on Day 2 was unaffected by whether they had played the climbing game on Day 1. Sickness during virtual climbing was also unaffected by group differences in exposure to the virtual rollercoaster. This convergent evidence suggested that the reductions in cybersickness produced by repeated exposure to HMD VR were game-specific. While these benefits did not generalise to the second game, two 15-min exposures to the same HMD VR game was sufficient to significantly reduce cybersickness in this study.
Census-based typological usability fragility curves for Italian unreinforced masonry buildings
Authors: Zucconi Maria , Di Ludovico Marco , Sorrentino Luigi 
Published: March 2022

AbstractThe main vulnerability models available in the literature aim to develop damage fragility curves to estimate the damage level suffered by a building after a seismic event. However, recent earthquakes have highlighted the great importance of predicting the usability of residential buildings, i.e. the condition of a building being habitable or occupiable after a seismic event. The building usability performance can be used as an indicator for allocating economic funding after a seismic event because recent researches have demonstrated a stronger correlation between repair costs and usability assessment rather than between repair costs and structural damage. Therefore, this work focused on the development of census-based fragility curves for the preventive forecast of the usability of Italian unreinforced-masonry buildings. The proposed usability model was calibrated based on the 2009 L'Aquila earthquake database, including almost 60,000 unreinforced-masonry buildings, and this database was increased by adding data from the Italian census to account for uninspected constructions. Six typological classes were defined considering two parameters available both in the post-earthquake and Italian census databases: construction timespan and state of repair. Additionally, it was highlighted in which cases the number of stories was also relevant. The usability fragility curves were defined as a function of peak ground acceleration for two building usability states: partially unusable and unusable. The results confirmed that older buildings are more vulnerable and clearly pointed out the crucial role of the state of repair as a parameter influencing the building usability.
Clinicopathological characteristics and prognostic analysis of tumor-infiltrating lymphocytes (TILs) in ductal carcinoma in situ (DCIS) and DCIS with microinvasion (DCIS-Mi) of the breast
Authors: Jia Huiqing , Zhao Peng , Chen Zhaoxu , Wang Guanqun , Dong Xianning , Xing Xiaoming , Tan Xiaohua , Wang Chengqin 
Published: March 2022

Abstract
Objective
Our purpose is to evaluate the correlation of TILs with clinicopathological characteristics and disease free survival (DFS) in DCIS and DCIS-Mi breast cancer (BC) patients.

Methods
We retrospectively reviewed the data of 360 DCIS patients and 125 DCIS-Mi patients treated by a single institution from 2016 to 2019. TILs are regarded as continuous variables and are divided into low (≤ 5%), medium (5–40%) and high (≥ 40%) for statistical analysis.

Results
In DCIS and DCIS-Mi patients, larger tumor size, higher nuclear grade, hormone receptor (HR) negativity and human epidermal growth factor receptor 2(HER2) overexpression are all related to high TILs (P < 0.05). In addition, compared with DCIS, DCIS-Mi patients were significantly associated with high TILs (P < 0.001). Based on the different results of the subtypes, we further studied the correlation between TILs and DFS in 279 cases of HER2+ patients (204 of DCIS; 75 of DCIS-Mi). In HER2+ group, DCIS-Mi was significantly associated with HR negativity (P = 0.015) and high TILs (P = 0.002) compared with DCIS patients. In the survival analysis, we found that TILs had no effect on the DFS of DCIS (P = 0.938), DCIS-Mi (P = 0.807), and HER2+ (P = 0.379) BC patients. In the univariate and multivariate cox regression analysis, the correlation between TILs and the prognosis of DFS has not been confirmed in the three BC groups (P > 0.05).

Conclusion
TILs have played an non-negligible role in the progress of DCIS to DCIS-Mi, especially in HER2+ BC. The predictive and prognostic value of TILs still needs further research to confirm.
“I Know Hyena. Do you Know Hyena?” Challenges in Interpreter-Mediated Dementia Assessment, Focusing on the Role of the Interpreter
Authors: Torkpoor Rozita , Fioretos Ingrid , Essén Birgitta , Londos Elisabet 
Published: March 2022

AbstractDementia assessment requires functional communication and interaction between healthcare professionals and the patient being assessed. These can be affected by the requirement for an interpreter to communicate with the patient. The purpose of this study was to elucidate the interactions between patient, healthcare professionals and interpreter, focusing on the role of the interpreter and the challenges that may arise in interpreter-mediated dementia assessment. The study had an ethnographic design in which the data consisted of audio and video recordings of 19 dementia assessments conducted in the presence of an interpreter. The data were analyzed using the constant comparative method. The results showed that the interpreter could affect the patient’s performance and results during the dementia assessment. The interpreter could alter the meaning and content of what was communicated, sometimes change information and instructions exchanged between the patient and healthcare professionals, could avoid interpreting everything being said, and occasionally made their own corrections to what was being communicated. This occurred mainly because of the interpreter’s lack of linguistic skills and the interpreter failing to adhere to the ethical guidelines governing their profession. These challenges could also occur when the interpreter was not familiar with the context of dementia assessment. Alterations made by the interpreter to what was being communicated could lead to incorrect evaluation of the patient’s cognitive abilities and health status. This, in turn, may lead to misjudgment of the patient’s remaining resources and symptoms and their required treatment and support.
Materials systems for interleave toughening in polymer composites
Authors: Vallack Nicola , Sampson William W. 
Published: March 2022

AbstractWe review the literature describing the use of interleaves to increase interlaminar fracture toughness in fibre-reinforced polymer composites and hence to improve damage tolerance. From an analysis of data provided in the literature from the use of microfibre and nanofibre interleaves, we show that the performance of these widely researched systems is clearly differentiated when plotted against the mean coverage of the interleaf. Using a simple analysis, we suggest that this can be attributed to the influence of their porous architectures on the infusion of resin. We show also that the superior toughening performance of microfibre interleaves is only weakly influenced by the choice of fibre. We find also that the inclusion of carbon nanotubes within interleaves to deliver multifunctional composites can be optimised by using a hybrid system with microfibres.
Graphical abstract