bluuebunny/crossref_metadata_2025_split huggingface dataset:
Прогнозування біологічної активності похідних амінометансульфонової кислоти
Authors: Антоненко П. Б. , Хома Р. Є. , Рожковський Я. В. , Кресюн В. Й. 
Published: August 2022

Одним з найперспективніших шляхів розробки потенційних лікарських препаратів залишається спрямований синтез нових сполук, у тому числі серед похідних амінометансульфонової кислоти (АMSA). Мета дослідження – оцінка потенційної біологічної та фармакологічної активності низки похідних АMSA за допомогою комп’ютерної системи PASS. Розрахунок потенційної біологічної активності похідних AMSA проводили за допомогою PASS (Prediction of Activity Spectra for Substances). Показник (імовірності) Ра від 0,7 до 1,0 свідчить про високу ймовірність активності. Були досліджені: N-(2-гідроксиетил)-AMSA (HEAMSA), N-(пропіл)AMSA (PrAMSA), N-(бутил)-AMSA (BuAMSA), N-(трет-бутил)-AMSA (tBuAMSA), N-(гептил)-AMSA (HpAMSA), 4-(N-феніламінометил)феніл-AMSA (PhAMPhAMSA), N-(бензил)-AMSA (BzAMSA). За результатами дослідження в чотирьох сполук (HEAMSA > BzAMSA > PrAMSA > tBuAMSA; Pa = 0,702…0,822) передбачається здатність пригнічувати глікозилфосфотидилінозитол фосфоліпазу D, що вказує на можливість пригнічувати ріст пухлинних і стовбурових клітин. Сполуки HEAMSA, PrAMSA, BuAMSA, tBuAMSA, HpAMSA виявили здатність пригнічувати екзорибонуклеазу ІІ, що зумовлює наявність противірусної активності. Практично всі досліджувані сполуки ймовірно пригнічують активність ферментів ендоглюкозилцерамідази та цукор-фосфатази, що може зумовлювати гіпоглікемічну активність. При цьому за останньою активністю Ра = 0,732…0,815, а за силою дії сполуки розташувались наступним чином: HpAMSA > BuAMSA > PrAMSA > HEAMSA > tBuAMSA > BzAMSA. У всіх досліджених похідних АМSA, крім BzAMSA, прогнозується антигіпоксична активність, за силою якою сполуки розташувались наступним чином: BuAMSA > HpAMSA > HEAMSA > PrAMSA > tBuAMSA > PhAMPhAMSA (Pa = 0,705…0,814). Сполуки HEAMSA і PrAMSA можуть викликати анксіолітичну дію, сполука tBuAMSA – аналгетичну дію, PhAMPhAMSA – антипіретичну дію, сполуки BuAMSA, HpAMSA можуть пригнічувати про-опіомеланокортин (РОМС) конвертуючий фермент. РОМС є прогормоном, з якого утворюються адренокортикотропний і меланоцит-стимулюючий гормони, а також бета-ліпотропін і бета-ендорфін. Тому пригнічення процесу лізису РОМС може впливати на ендокринну й антиноцицептивну системи. Таким чином, наведені дані свідчать про перспективність доклінічного дослідження нових похідних амінометансульфонової кислоти.
Вивчення вмісту полісахаридів у траві самосилу гайового та самосилу гірського
Authors: Анзіна К. М. , Гудзенко А. В. 
Published: August 2022

Серед різноманіття представників флори України трапляються рослини, що активно використовуються в народній медицині, але вміст біологічно активних речовин в них вивчено недостатньо. Важливим елементом будь-якого цілісного фармакогностичного дослідження є вивчення кількісного вмісту вуглеводів у рослинній сировині. Вуглеводи відіграють ключову роль у формуванні питомої маси рослинного організму. У рослинах найбільшу кількість вуглеводів складають полісахариди. Полісахариди рослинного походження виявляють високу біологічну активність, потенціюють фармакологічну активність біологічно активних речовин, пролонгують дію та підвищують ефективність застосування лікарських засобів, мають протизапальну, муколітичну, імуномодулюючу, протипухлинну дію. Мета дослідження – вивчення вмісту водорозчинних полісахаридів, пектинових речовин, а також геміцелюлози А та Б у траві самосилу гайового (Teucrium сhamaedrys L.) та самосилу гірського (Teucrium montanum L.). Для виділення полісахаридів була використана методика Н. К. Кочеткова. Визначення вмісту полісахаридів проводили гравіметричним методом, використовуючи електронні аналітичні ваги Radwag (Польща) серії AS 220/C. Встановлено, що серед фракцій полісахаридів найбільший відсоток складали водорозчинні полісахариди (3,12 % у самосилі гайовому та 2,81 % у самосилі гірському), найменший – фракція геміцелюлози Б (1,08 % у самосилі гайовому та 0,92 % у самосилі гірському). Вміст пектинових речовин становив 1,22 % у самосилі гайовому та 0,97 % у самосилі гірському, геміцелюлози А – 2,63 % і 2,36 % відповідно. Отримані результати щодо полісахаридного складу можна використовувати для подальшого дослідження сировини самосилу гайового та самосилу гірського та при розробці методик контролю якості на лікарську сировину та субстанції на її основі.
EFEKTIVITAS REBUSAN JAHE DAN VITAMIN B6 DALAM MENGATASI MORNING SICKNESS: LITERATUR REVIEW
Authors: Nabila Sarah , Hidayah Nurul , Maolinda Winda 
Published: August 2022

Latar Belakang : Sekitar 50-90% wanita hamil memiliki keluhan mual dan muntah (Morning Sickness). Salah satu komplikasi yang terjadi pada kehamilan adalah mual muntah yang jika tidak ditangani akan menjadi mual muntah berlebihan (Hiperemesis Gravidarum) Pemberian rebusan jahe dan vitamin B6 merupakan salah satu alternatif terapi yang dapat digunakan membantu ibu dalam mengatasi morning sickness.Tujuan : Mengetahui efektifitas rebusan jahe dan Vitamin B6 dalam mengatasi morning sickness: Literatur ReviewMetode : Penelitian ini menggunakan pendekatan literatur review dengan menggunakan beberapa sumber melalui Google Schoolar, Portal Garuda, dan Pubmed.Hasil : Database yang didapatkan dari 10 literatur menyatakan bahwa ada pengaruh pemberian rebusan jahe dan vitamin B6 dalam mengatasi morning sickness, 6 literatur mengatakan rebusan jahe Â saja dapat mengatasi morning sickness dan 4 literatur menyatakan bahwa vitamin B6 dapat menurunkan frekuensi morning sickness. Dari 10 literatur terdapat 3 literatur menyatakan bahwa rebusan jahe dikombinasikan dengan Vitamin B6 lebih efektif menurunkan frekuensi dan mengatasi morning sicknessKesimpulan : Berdasarkan literatur review dari 10 jurnal penelitian didapatkan rebusan jahe lebih efektif mengatasi morning sickness daripada vitamin B6.Â Kata Kunci : Morning Sickness, Rebusan Jahe, Vitamin B6.Â Introduction : 50-90% of pregnant women complain of nausea and vomiting (Morning Sickness). One of the complications that occur in pregnancy is nausea and vomiting, which if left untreated will lead to excessive nausea and vomiting (Hyperemesis Gravidarum). Ginger and vitamin B6 decoction is an alternative therapy that can be used to help mothers overcome morning sickness..OBJECTIVE: Knowing the efficacy of ginger and vitamin B6 decoction in overcoming morning sickness: Literature ReviewMethods : This study uses a literature review approach using several sources through Google Schoolar, Garuda Portal, and Pubmed.Results : The database obtained from 10 literature states that there is an effect of giving boiled ginger and vitamin B6 in overcoming morning sickness, 6 literatures say that ginger stew alone can overcome morning sickness and 4 literatures state that vitamin B6 can reduce the frequency of morning sickness. From 10 literatures, there are 3 literatures stating that ginger decoction combined with Vitamin B6 is more effective in reducing the frequency and overcoming morning sickness.Conclusions : Based on the literature review from 10 research journals, it was found that ginger decoction was more effective in dealing with morning sickness than vitamin B6.Â Keyword : Morning sickness, Ginger Stew, Vitamin B6.
EFEKTIVITAS PEMBERIAN UBI JALAR UNGU PADA IBU HAMIL TERHADAP PENINGKATAN KADAR HEMOGLOBIN: NARRATIVE REVIEW
Authors: Ranti Ranti , Haryono Ika Avrilina , Zulliati Zulliati 
Published: August 2022

ABSTRAKÂ Latar Belakang: Banyak ibu hamil yang mengalami anemia selama masa kehamilan karena ibu hamil mengalami perubahan fisiologis pada setiap trimester sehingga menyebabkan rendahnya kadar hemoglobin. Pemberian ubi jalar ungu salah satu terapi komplementer yang dapat membantu ibu dalam meningkatkan kadar hemoglobin.Tujuan: Mengkaji efektivitas pemberian ubi jalar ungu pada ibu hamil terhadap peningkatan kadar hemoglobin dengan literatur review pada beberapa artikel yang relevan.Metode: Metode pencarian artikel ini dengan menggunakan kata kunci ubi jalar ungu untuk ibu hamil anemia, iron and purple sweet potato dari database portal garuda, DOAJ dan google scholar adapun kriteria inklusi yang digunakan artikel yang akan ditelaah berdasarkan kata kunci, artikel berupa full paper dan tidak terbatas metode artikel yang akan direview serta artikel minimal terbitan 5 tahun kebawah.Hasil: Dari beberapa artikel menyatakan bahwa pemberian ub jalar ungu dalam bentuk rebusan, snack, dan sulfaktan dapat meningkatkan kadar hemoglobin karena ubi jalar ungu memiliki kaya akan kadar zat besi 4 mg dan vitamin C 20 mg.Simpulan: Ubi jalar ungu merupakan suatu makanan alternative yang dapat membantu meningkatkan kadar hemoglobin didalam sel darah merah terhadap ibu hamil.Â Kata Kunci: Ubi jalar Ungu, Kadar hemoglobin, Ibu hamilÂ ABSTRACTBackground: Many pregnant women experience anemia during pregnancy because pregnant women experience physiological changes in each trimester, causing low hemoglobin levels. Giving purple sweet potato is a complementary therapy that can help mothers in increasing hemoglobin levels.Â Objective: To assess the effectiveness of giving purple sweet potato to pregnant women to increase hemoglobin levels by reviewing literature on several relevant articles.Â Methods: The search method for ths article uses the keyword purple sweet potato for anemia pregnant women, iron ad purple sweet potao from the garuda, DOAJ and google scholar portal database. Metod of article to be reviewed and articles published at least 5 yaer and under.Results: Several articles state that giving purple seeet potato in the form of stew, snack and sulfactants can increase hemoglobin levels because purple sweet potato are rih in iron levels of 4 mg and vitamin C 20 mg.Conclusion: Purple sweet potato is an alternative food that can help increase hemoglobin levels in red blood cells in pregnant women.Â Keywords: Purple Sweet Potatoes, Hemoglobin Levels, Pregnant Women
Temperature-dependent compatibility study on halide solid-state electrolytes in solid-state batteries
Authors: Jia Gaoshuai , Deng Zhi , Ni Dixing , Ji Zhaoran , Chen Diancheng , Zhang Xinxin , Wang Tao , Li Shuai , Zhao Yusheng 
Published: August 2022

All-solid-state lithium batteries (ASSLBs) have attracted much attention owing to their high safety and energy density compared to conventional organic electrolytes. However, the interfaces between solid-state electrolytes and electrodes retain some knotty problems regarding compatibility. Among the various SSEs investigated in recent years, halide SSEs exhibit relatively good interfacial compatibility. The temperature-dependent interfacial compatibility of halide SSEs in solid-state batteries is investigated by thermal analysis using simultaneous thermogravimetry and differential scanning calorimetry (TG–DSC) and X-ray diffraction (XRD). Halide SSEs, including rock-salt-type Li3InCl6 and anti-perovskite-type Li2OHCl, show good thermal stability with oxides LiCoO2, LiMn2O4, and Li4Ti5O12 up to 320 °C. Moreover, anti-perovskite-type Li2OHCl shows a chemical reactivity with other battery materials (eg., LiFePO4, LiNi0.8Co0.1Mn0.1O2, Si-C, and Li1.3Al0.3Ti1.7(PO4)3) at 320°C, which reaches the melting point of Li2OHCl. It indicated that Li2OHCl has relatively high chemical reactivity after melting. In contrast, rock-salt-type Li3InCl6 shows higher stability and interfacial compatibility. This work delivers insights into the selection of suitable battery materials with good compatibility for ASSLBs.
Metagenomic next-generation sequencing: A promising tool for diagnosis and treatment of suspected pneumonia in rheumatic patients with acute respiratory failure: Retrospective cohort study
Authors: Shi Yan , Peng Jin-Min , Qin Han-Yu , Du Bin 
Published: August 2022

BackgroundThe effectiveness of metagenomic next-generation sequencing (mNGS) in respiratory pathogen detection and clinical decision-making in critically rheumatic patients remains largely unexplored.MethodsA single-center retrospective study of 58 rheumatic patients who were admitted to ICU due to suspected pneumonia with acute respiratory failure if they underwent both bronchoalveolar lavage fluid specimen mNGS and combined microbiological tests (CMTs) was conducted to compare their diagnostic performance, using clinical composite diagnosis as the gold standard. Treatment modifications based on mNGS results were also reviewed.ResultsForty-three patients were diagnosed with microbiologically confirmed pneumonia and 15 were considered as a non-infectious disease. mNGS outperformed CMTs in the accurate diagnosis of infectious and non-infectious lung infiltration (98.1% [57/58] vs. 87.9% [51/58], P = 0.031). A total of 94 causative pathogens were defined by the gold standard and 27 patients had polymicrobial pneumonia. The sensitivity of pathogen detection and complete concordance with the gold standard by mNGS exceeded those by CMTs (92.6% [87/94] vs. 76.6% [72/94], P &lt; 0.001 and 72.1% [31/43] vs. 51.2% [22/43], P = 0.004, respectively). Moreover, 22 pathogens were detected only by mNGS and confirmed by orthogonal test. Accordingly, the etiological diagnosis changed in 19 cases, and the empirical treatment improved in 14 cases, including 8 cases of rescue treatment and 11 of antibiotics de-escalation. At the pathogen-type level, both methods were comparable for bacteria, but mNGS was advantageous to identify viruses (accuracy: 100% vs. 81%, P = 0.004). For Pneumocystis jirovecii detection, mNGS improved the sensitivity compared with Gomori’s methenamine silver stain (91.7% vs. 4.2%, P &lt; 0.001) and was higher than polymerase chain reaction (79.2%), but the difference was not significant (P = 0.289). In terms of Aspergillus, the better sensitivity with a combination of culture and galactomannan test than that with mNGS was found (100% vs. 66.7%, P = 0.033).ConclusionsmNGS has an excellent accuracy in etiological diagnosis and pathogen detection of suspected pneumonia in critically rheumatic patients, which has potential significance for clinical decision-making. Its superiority to different types of pathogens depends on the comprehensiveness of CMTs.
Ataxia telangiectasia mutated: The potential negative regulator in platelet-derived growth factor-BB promoted proliferation of pulmonary arterial smooth muscle cells
Authors: Qin Chaoyi , Zan Yiheng , Xie Liang , Liu Hanmin 
Published: August 2022

ObjectiveTo study the role of ataxia telangiectasia mutated (ATM) in the platelet-derived growth factor (PDGF)-BB-induced proliferation of pulmonary arterial smooth muscle cells (PASMCs) through reactive oxygen species (ROS) formation.MethodsPrimary cultures of PASMCs were treated with different concentrations of PDGF-BB or exogenous hydrogen peroxide (H2O2). The activation level of ATM and the proliferation level of PASMCs were measured by immunofluorescence staining and Cell Counting Kit-8, respectively. Moreover, NADPH oxidase 2 (NOX2) and intracellular H2O2 were detected under the stimulation of different levels of PDGF-BB by Western blot and dihydroethidium staining.ResultsBoth the control group and 50 ng/ml of the PDGF-BB group showed significantly higher levels of phosphorylation ATM compared to other groups (P &lt; 0.05). With the ATM inhibitor, 50 ng/ml of the PDGF-BB group showed further increased proliferative level compared to the 10 ng/ml (P &lt; 0.05). Both the levels of NOX2 and H2O2 showed dose-dependent manners under PDGF-BB stimulation (P &lt; 0.05). ATM could be activated by H2O2 upon a dose-dependent way, except for the 500 μM H2O2 group. Under 200 μM H2O2 stimulation, proliferation level decreased significantly (P &lt; 0.05), while no significant difference was shown with the addition of ATM inhibitor (P &gt; 0.05).ConclusionOur study first established ROS-induced ATM activation in PDGF-BB-stimulated proliferation of PASMCs. Inhibition of ATM had promoted effects on the proliferation of PASMCs under the excessive levels of PDGF-BB and H2O2. Our study might provide a novel promising target for the treatment of pulmonary arterial hypertension (PAH).
External validation and comparison of two delirium prediction models in patients admitted to the cardiac intensive care unit
Authors: Kim Sung Eun , Ko Ryoung-Eun , Na Soo Jin , Chung Chi Ryang , Choi Ki Hong , Kim Darae , Park Taek Kyu , Lee Joo Myung , Song Young Bin , Choi Jin-Oh , Hahn Joo-Yong , Choi Seung-Hyuk , Gwon Hyeon-Cheol , Yang Jeong Hoon 
Published: August 2022

BackgroundNo data is available on delirium prediction models in the cardiac intensive care unit (CICU), although preexisting delirium prediction models [PREdiction of DELIRium in ICu patients (PRE-DELIRIC) and Early PREdiction of DELIRium in ICu patients (E-PRE-DELIRIC)] were developed and validated based on a population admitted to the general intensive care unit (ICU). Therefore, we externally validated the usefulness of the PRE-DELIRIC and E-PRE-DELIRIC models and compared their predictive performance in patients admitted to the CICU.MethodsA total of 2,724 patients admitted to the CICU were enrolled between September 2012 and December 2018. Delirium was defined as at least one positive Confusion Assessment Method for the ICU (CAM-ICU) which was screened at least once every 8 h. The PRE-DELIRIC value was calculated within 24 h of CICU admission, and the E-PRE-DELIRIC value was calculated at CICU admission. The predictive performance of the models was evaluated by using the area under the receiver operating characteristic (AUROC) curve, and the calibration slope was assessed graphically by plotting.ResultsDelirium occurred in 677 patients (24.8%) when the patients were assessed thrice daily until 7 days of the CICU stay. The AUROC curve for the prediction of delirium was significantly greater for PRE-DELIRIC values [0.84, 95% confidence interval (CI): 0.82–0.86] than for E-PRE-DELIRIC values (0.79, 95% CI: 0.77–0.80) [z score of −6.24 (p &lt; 0.001)]. Net reclassification improvement for the prediction of delirium increased by 0.27 (95% CI: 0.21–0.32, p &lt; 0.001). Calibration was acceptable in the PRE-DELIRIC model (Hosmer-Lemeshow p = 0.170) but not in the E-PRE-DELIRIC model (Hosmer-Lemeshow p &lt; 0.001).ConclusionAlthough both models have good predictive performance for the development of delirium, even in critically ill cardiac patients, the performance of the PRE-DELIRIC model might be superior to that of the E-PRE-DELIRIC model. Further studies are required to confirm our results and design a specific delirium prediction model for CICU patients.
Efficacy of radiofrequency ablation for metastatic papillary thyroid cancer with and without initial biochemical complete status
Authors: Chen Wen-Chieh , Chou Chen-Kai , Chang Yen-Hsiang , Chiang Pi-Ling , Lim Lay-San , Chi Shun-Yu , Luo Sheng-Dean , Lin Wei-Che 
Published: August 2022

ObjectiveThe application of radiofrequency ablation (RFA) for recurrent thyroid cancer has been demonstrated to effectively manage lesions at critical locations, such as abutting the trachea, with limited complications. Comprehensive investigation of both biochemical (B) and structural (S) change after RFA remains limited. We herein present the first single-center experience of RFA for the treatment of locoregional recurrent thyroid cancer in Taiwan.Design23 patients were enrolled, and the treatment responses after RFA were divided into four groups (E, S(+), B(+), and SB(+)), and then compared. The RFA technique, follow-up strategy, changes in pre-and post-operative status, and complications are presented. The volume reduction rate at 1, 3, and 6 months, and the differing responses between lesions abutting/not abutting the trachea are also discussed.ResultsIn patients with pre-RFA structural and biochemical incomplete (SB(+)) status, presenting with lesion with an initial maximum diameter of &gt;3.2cm, a higher rate of structural incomplete status at the 6-month follow-up was noted in ROC analysis, with a sensitivity of 57% and specificity of 91%. Favorable structural remission after RFA was noted, and 60.9% of patients achieved biochemical complete status. No significant correlation was noted between the trachea-abutted lesion number and complete remission (p= 0.474). No significant difference in RFA efficacy was noted between the lesions abutting/not abutting the trachea.ConclusionsThis retrospective study reveals that RFA can achieve both structural and biochemical improvements for locoregionally recurrent thyroid cancer, with a low complication rate. Nearly half of the patients achieved an excellent response after RFA, while a favorable treatment response can be achieved despite the lesion abutting the trachea, with a mean VRR of 84.74%.
Heavy metal levels and sources in suspended particulate matters of the glacier watersheds in Northeast Tibetan Plateau
Authors: Wu Rui , Dong Zhiwen , Cheng Xiping , Brahney Janice , Jiao Xiaoyu , Wu Lihua 
Published: August 2022

This study collected summer meltwater runoff samples from several glacier watersheds of the northeast Tibetan Plateau during June-July 2017, and measured the concentrations of 17 trace elements (Li, Be, Sc, V, Cr, Co, Ni, Cu, Zn, Ga, Rb, Mo, Cd, In, Sb, Cs, Ba) in meltwater suspended particulate matter (SPM), in order to reveal the elemental concentration, spatial distribution, and water quality in remote glacier watershed under regional anthropogenic activities. Results showed that, the concentration of heavy metal elements was relatively high in Yuzhufeng Glacier basin, ranging from 0.57 μg/L (In) to 1,551.6 μg/L (Ba), whereas in Qiyi Glacier basin it was the lowest, ranging from 0.02 to 85.05 μg/L; and relatively medium in other glacier watersheds, with total elemental concentration varying from 1,503.9 to 1726.2 μg/L. Moreover, enrichment factors (EFs) of SPM heavy metals showed significantly higher value in the downstream than that of upper glacier region of the watershed. Most heavy metals with low EFs mainly originated from crust dust, while others with higher EFs (e.g., Cd, Sb) probably originated from anthropogenic sources. Spatially, the EFs of heavy metals were higher in Yuzhufeng and Laohugou Glacier basins; while in other regions the EFs were relatively low, which may be caused by regional land-surface and atmospheric environmental differences surrounding the various glacier watersheds. Compared with other remote locations in global range, heavy metals level (e.g., Cu, Ni, and Zn) in this region is relatively higher. Meanwhile, we find that, though the water quality of the glacier basin in northeast Tibetan Plateau was relatively clean and pollution-free, it is still obviously affected by regional anthropogenic activities. Mining activities, transportation and natural weathering and erosion processes in the study areas have important effects on the content of heavy metal pollutants of river-water SPM in the glacier watershed. Moreover, backward air-mass trajectories demonstrated the potential atmospheric pollutants transport from the surrounding cities and suburbs, to deposit in the snowpack and glaciers, and then melted out and released into meltwater runoff. This study provides a new perspective on more complete view of heavy metals distribution in glacier watershed, and new understanding for the cryosphere water environment evaluation in the Tibetan Plateau region.