bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS SUB ASPEK KERUNTUTAN PENYAJIAN BUKU TEKS MATEMATIKA SMP KELAS VII KURIKULUM 2013 TERBITAN ERLANGGA REVISI TAHUN 2016 PADA POKOK BAHASAN PERBANDINGAN
Authors: Pratiwi Endah , Susanta Agus , Siagian Teddy Alfra 
Published: August 2022

AbstrakPenelitian ini bertujuan untuk mendeskripsikan aspek penyajian buku teks matematika SMP kelas VII semester 2 kurikulum 2013 tebitan Erlangga revisi tahun 2016 pada pokok bahasan perbandingan yang ditinjau dari sub aspek keruntutan penyajian yang terdiri dari tiga butir penilaian yaitu penyajian materi sesuai dengan alur berpikir induktif untuk membuat dugaan atau alur berpikir deduktif untuk menyatakan proposisi, konsep disajikan dari yang mudah ke yang sukar, dan materi prasyarat disajikan mendahului materi pokok. Jenis penelitian ini adalah Penelitian Deskriptif Kualitatif (Descriptive Qualitative Research). Subjek dalam penelitian ini adalah buku teks Matematika untuk SMP Kelas VII Semester 2 terbitan Erlangga Karangan M.Cholik Adinawan pada pokok bahasan perbandingan yang terdiri dari delapan sub pokok bahasan yaitu gambar berskala, mengenal perbandingan, menyatakan dan menyelesaikan perbandingan, perbandingan senilai, perbandingan berbalik nilai, grafik perbandingan, penerapan perbandingan dalam kehidupan sehari-hari, variasi perbandingan senilai dan berbalik nilai. Instrumen dalam penelitian ini adalah lembar penilaian buku teks dari BSNP. Hasil penelitian ini menunjukkan bahwa kesesuaian buku teks matematika ditinjau dari sub aspek keruntutan penyajian dikategorikan sangat sesuai dengan persentase sebesar 89,58%.Kata kunci : Analisis, Buku Teks Matematika, BSNP, Kesesuaian AbstractThis study aims to describe the aspects of the presentation of the mathematics textbook for class VII semester 2 of the 2013 curriculum published by Erlangga in the 2016 revision on the subject of comparison in terms of sub-aspects of presentation clutter consisting of three points of assessment, namely the presentation of material according to the inductive thinking flow to make assumptions. or deductive thought flow to state propositions, concepts are presented from easy to difficult ones, and prerequisite material is presented before the subject matter. This type of research is Descriptive Qualitative Research (Descriptive Qualitative Research). The subjects in this study were the Mathematics textbook for Class VII Semester 2 Junior High School published by Erlangga Karangan M. Cholik Adinawan on the subject of comparison consisting of eight sub-subjects, namely scaled images, recognizing comparisons, stating and completing comparisons, comparisons of value, comparisons of turning values. , comparison charts, the application of comparisons in everyday life, variations in value comparisons and reversed values. The instrument in this study was a textbook assessment sheet from BSNP. The results of this study indicate that the suitability of mathematics textbooks in terms of the sub-aspects of presentation clutter is categorized as very suitable with the percentage of 89.58%. Keywords :Analysis, Textbook of Math, BSNP,Suitability
Penerapan Model Pembelajaran Kooperatif tipe Make A Match berbantuan Media Gambar untuk Meningkatkan Hasil Belajar Matematika Siswa
Authors: Lestari Karlya Dwi Upika , Maizora Syafdi , Susanta Agus , Lestary Ratnah 
Published: August 2022

Penelitian ini bertujuan untuk meningkatkan aktivitas dan hasil belajar peserta didik pada materi segiempat dan segitiga di SMPN 15 Kota Bengkulu melalui penerapan model pembelajaran kooperatif tipe Make A Match berbantuan media gambar. Jenis penelitian ini adalah penelitian tindakan kelas. Subjek penelitian ini adalah siswa kelas VII A SMPN 15 Kota Bengkulu Semester Genap Tahun Ajaran 2018/2019 yang berjumlah 29 siswa yang terdiri dari 13 siswa laki-laki dan 16 siswa perempuan. Penelitian dilaksanakan dalam 3 siklus dari tanggal 15 Maret 2019 sampai dengan 07 Mei 2019. Instrumen yang digunakan dalam penelitian ini adalah lembar observasi dan lembar tes. Hasil penelitian menunjukkan bahwa penerapan model pembelajaran kooperatif tipe Make A Match berbantuan media gambar dapat meningkatkan aktivitas dan hasil belajar siswa dapat dilihat dari nilai rata-rata observasi siswa berupa self checklist siklus I, II, dan III secara berturut-turut yaitu 37.25, 41.5, 46.5 dengan kriteria secara berturut-turut adalah baik, baik, sangat baik. Peningkatan hasil belajar siswa dapat dilihat dari nilai rata-rata hasil belajar siklus I, II, dan III secara berturut-turut 62.86 , 71,05 dan 80.20 dengan ketuntasan klasikal pada siklus I, II dan III secara berturut-turut adalah 31,03%, 58,62% dan 82,75%.Kata Kunci : Aktivitas Belajar, Hasil Belajar, Pembelajaran Make A Match, Media Gambar.
PENERAPAN PENDEKATAN SAINTIFIK DENGAN BANTUAN ALAT PERAGA TRADISIONAL UNTUK MENINGKATKAN HASIL BELAJAR MATEMATIKA KELAS VIII SMPN 2 KOTA BENGKULU
Authors: Girsang Melan Kristina , Hanifah Hanifah , Siagian Teddy Alfra , Stiadi Elwan 
Published: August 2022

Penelitian ini bertujuan untuk mengetahui cara penerapan pendekatan Saintifik dengan bantuan alat peraga tradisional sehingga dapat meningkatkan hasil belajar matematika siswa kelas VIII SMPN 2 Kota Bengkulu. Jenis penelitian yang digunakan adalah Penelitian Tindakan Kelas (PTK) dengan tes hasil belajar siswa. Subjek penelitian ini adalah siswa kelas VIII G SMPN 2 Kota Bengkulu tahun ajaran 2019/2020 yang beranggotakan 35 orang siswa. Penelitian ini dilaksanakan dalam 1 siklus dengan materi penelitian adalah teorema Pythagoras. Hasil penelitian menunjukkan bahwa pendekatan Saintifik dengan bantuan alat peraga dapat meningkatkan hasil belajar matematika siswa. Peningkatan hasil belajar siswa dapat dilihat dari nilai rata-rata hasil belajar siswa pra siklus dengan siklus 1. Rata-rata hasil belajar matematika siswa pra siklus adalah 63.71 dengan ketuntasan belajar klasikal 42.85% dan pada siklus 1 rata-rata hasil belajar matematika siswa adalah 73.28 dengan ketutasan belajar klasikal 68.57%.
Analisis Tingkat Kognitif Soal Uji Kompetensi Buku Teks Matematika Terbitan Erlangga Kelas VIII Semester 1 Berdasarkan Taksonomi Bloom Revisi
Authors: Verina Imelda , Hanifah Hanifah , Irsal Nur Aliyyah , Stiadi Elwan 
Published: August 2022

Penelitian ini bertujuan untuk mendeskripsikan sebaran tingkat kognitif pada soal uji kompetensi dalam buku teks matematika terbitan Erlangga kelas VIII semester 1 bab relasi dan fungsi serta sistem persamaan linear dua variabel berdasarkan taksonomi bloom revisi. Jenis penelitian ini adalah penelitian deskriptif yaitu dilakukan analisis untuk menggambarkan atau mendeskripsikan tingkatan taksonomi bloom pada dimensi proses kognitif soal mata pelajaran matematika. Sumber data dalam penelitian ini adalah soal uji kompetensi dalam buku matematika kelas VIII semester 1 kurikulum 2013 terbitan Erlangga karya M. Cholik Adinawan pada bab relasi dan fungsi dan sistem persamaan linear dua variabel. Soal uji kompetensi bab relasi dan fungsi berjumlah 33 soal dan soal uji kompetensi bab sistem persamaan linear dua variabel berjumlah 30 soal. Pada soal uji kompetensi bab relasi dan fungsi memiliki tingkat kognitif memahami (C2) sebanyak 12 soal (36,36%), mengaplikasikan (C3) sebanyak 15 soal (45,46%), dan menganalisis (C4) sebanyak 6 soal (18,18%), dan tidak memuat tingkat kognitif mengingat (C1), mengevaluasi (C5), dan mencipta (C6). Sedangkan, soal uji kompetensi bab sistem persamaan linear dua variabel memiliki tingkat kognitif memahami (C2) sebanyak 1 soal (3,33%), mengaplikasikan (C3) sebanyak 22 soal (73,33%), menganalisis (C4) sebanyak 5 soal (16,67%), dan mengevaluasi (C5) sebanyak 2 soal (6,67%), dan tidak memuat tingkat kognitif mengingat (C1), dan mencipta (C6). Kata kunci: Buku Teks Matematika, Soal Uji Kompetensi, Taksonomi Bloom, Tingkat Kognitif
The burst of electrophysiological signals in the suprachiasmatic nucleus of mouse during the arousal detected by microelectrode arrays
Authors: Wang Yiding , Song Yilin , Dai Yuchuan , Li Xinrong , Xie Jingyu , Luo Jinping , Yang Chao , Fan Penghui , Xiao Guihua , Luo Yan , Wang Ying , Li Yinghui , Cai Xinxia 
Published: August 2022

The neural mechanisms of torpor have essential reference significance for medical methods and long-term manned space. Changes in electrophysiology of suprachiasmatic nucleus (SCN) conduce to revealing the neural mechanisms from the torpor to arousal. Due to the lower physiology state during the torpor, it is a challenge to detect neural activities in vivo on freely behaving mice. Here, we introduced a multichannel microelectrode array (MEA) for real-time detection of local field potential (LFP) and action potential (spike) in the SCN in induced torpor mice. Meanwhile, core body temperature and behaviors of mice were recorded for further analysis. Platinum nanoparticles (PtNPs) and Nafion membrane modified MEA has a lower impedance (16.58 ± 3.93 kΩ) and higher signal-to-noise ratio (S/N = 6.1). We found that from torpor to arousal, the proportion of theta frequency bands of LFPs increased, spike firing rates rapidly increased. These results could all be characteristic information of arousal, supported by the microscopic neural activity promoting arousal in mice. MEA displayed real-time dynamic changes of neuronal activities in the SCN, which was more helpful to analyze and understand neural mechanisms of torpor and arousal. Our study provided a factual basis for the neural state in SCN of induced non-hibernating animals, which was helpful for the application of clinics and spaceflight.
N-linoleyltyrosine ameliorates high-fat diet-induced obesity in C57BL/6 mice via cannabinoid receptor regulation
Authors: Yang Zheng-yu , Wu Yi-ying , Zhou Yi , Yang Yun-qi , Zhang Jia-hui , He Tao , Liu Sha 
Published: August 2022

ObjectivesN-linoleyltyrosine (NITyr) showed mild effects in preclinical studies. The research discussed the effect of NITyr on a high-fat diet (HFD) induced obese (DIO) mice, and preliminarily explored its mechanism.MethodsThe DIO mice were established by feeding an HFD for 12 weeks and subsequently administrated orally with NITyr (30, 60 and 100 mg/kg) for four weeks. The indexes of serum and liver samples were determined by ELISA kit. The pathological status of adipose and liver were detected by HE staining. The factors related to energy and lipid metabolism were measured via western blot.ResultsNITyr at 60 and 100 mg/kg/day suppressed the weight gain without affecting water and food intake. Accordingly, NITyr reduced adipose weight and the area of individual adipocytes and increased the number of adipocytes. Moreover, NITyr didn’t affect the appetite-related indexes such as ghrelin, peptide YY and brain-derived neurotrophic factor. Besides, NITyr didn’t affect other organ coefficients except for the liver. Correspondingly, NITyr reduced alanine aminotransferase and aspartate aminotransferase levels, yet didn’t influence IL-1β and TNF-α levels, and the liver injury. The levels of triacylglycerol (TG), total cholesterol (TC), glucose, insulin, adiponectin and leptin in serum were assessed to evaluate the effect of NITyr on glucose and lipid metabolism. NITyr decreased the levels of TG, TC and glucose, and didn’t affect insulin, adiponectin and leptin levels. Meanwhile, NITyr up-regulated p-AMPK and the cannabinoid receptor 2 (CB2) expressions, and down-regulated PPAR, FAS and cannabinoid receptor 1 (CB1) expressions.Overall, NITyr suppressed lipid accumulation via improving lipid and glucose metabolism involving CB1 and CB2 receptors.
Classification and biomarker gene selection of pyroptosis-related gene expression in psoriasis using a random forest algorithm
Authors: Song Jian-Kun , Zhang Ying , Fei Xiao-Ya , Chen Yi-Ran , Luo Ying , Jiang Jing-Si , Ru Yi , Xiang Yan-Wei , Li Bin , Luo Yue , Kuai Le 
Published: August 2022

Background: Psoriasis is a chronic and immune-mediated skin disorder that currently has no cure. Pyroptosis has been proved to be involved in the pathogenesis and progression of psoriasis. However, the role pyroptosis plays in psoriasis remains elusive.Methods: RNA-sequencing data of psoriasis patients were obtained from the Gene Expression Omnibus (GEO) database, and differentially expressed pyroptosis-related genes (PRGs) between psoriasis patients and normal individuals were obtained. A principal component analysis (PCA) was conducted to determine whether PRGs could be used to distinguish the samples. PRG and immune cell correlation was also investigated. Subsequently, a novel diagnostic model comprising PRGs for psoriasis was constructed using a random forest algorithm (ntree = 400). A receiver operating characteristic (ROC) analysis was used to evaluate the classification performance through both internal and external validation. Consensus clustering analysis was used to investigate whether there was a difference in biological functions within PRG-based subtypes. Finally, the expression of the kernel PRGs were validated in vivo by qRT-PCR.Results: We identified a total of 39 PRGs, which could distinguish psoriasis samples from normal samples. The process of T cell CD4 memory activated and mast cells resting were correlated with PRGs. Ten PRGs, IL-1β, AIM2, CASP5, DHX9, CASP4, CYCS, CASP1, GZMB, CHMP2B, and CASP8, were subsequently screened using a random forest diagnostic model. ROC analysis revealed that our model has good diagnostic performance in both internal validation (area under the curve [AUC] = 0.930 [95% CI 0.877–0.984]) and external validation (mean AUC = 0.852). PRG subtypes indicated differences in metabolic processes and the MAPK signaling pathway. Finally, the qRT-PCR results demonstrated the apparent dysregulation of PRGs in psoriasis, especially AIM2 and GZMB.Conclusion: Pyroptosis may play a crucial role in psoriasis and could provide new insights into the diagnosis and underlying mechanisms of psoriasis.
Investigating the association of atopic dermatitis with ischemic stroke and coronary heart disease: A mendelian randomization study
Authors: Huang Jian , Gui Ying , Wu Jing , Xie Yubo 
Published: August 2022

Background: Atopic dermatitis (AD) is the most common chronic skin inflammatory disease. Prior observational studies have reported inconsistent results on the association of AD with ischemic stroke and coronary heart disease. In this study, we applied two-sample Mendelian randomization (MR) to evaluate the causal effect of AD on ischemic stroke and coronary heart disease.Methods: Twelve single-nucleotide polymorphisms robustly associated with AD (p &lt; 5 × 10–8) were obtained from a genome-wide association study that included 10,788 cases and 30,047 controls by the EArly Genetics and Life course Epidemiology (EAGLE) Consortium (excluding the 23andMe study). The corresponding data for ischemic stroke (34,217 cases and 406,111 controls), large artery stroke (4,373 cases and 406,111 controls), cardioembolic stroke (7,193 cases and 406,111 controls), small vessel stroke (5,386 cases and 192,662 controls), coronary heart disease (122,733 cases and 424,528 controls), and myocardial infarction (43,676 cases and 128,199 controls) were obtained from the MR-Base platform. In the primary MR analyses, we applied the inverse variance weighted method to evaluate the associations. We performed a sensitivity analysis using weighted median, MR-Egger, weighted mode, simple mode, Mendelian Pleiotropy RESidual Sum and Outlier (MR-PRESSO), and leave-one-out methods.Results: In the primary MR analyses, we found no causal association of genetically predicted AD with ischemic stroke [odds ratio (OR) = 1.00, 95% confidence interval (CI): 0.95–1.06], large artery stroke (OR = 1.02, 95% CI: 0.88–1.17), cardioembolic stroke (OR = 1.06, 95% CI: 0.94–1.18), small vessel stroke (OR = 1.05, 95% CI: 0.94–1.17), coronary heart disease (OR = 1.00, 95% CI: 0.94–1.05), and myocardial infarction (OR = 1.03, 95% CI: 0.98–1.09). The results from the primary MR analyses were supported in sensitivity analyses using the weighted median, weighted mode, simple mode, and MR-Egger methods and multivariable MR analyses adjusting for asthma and several traditional risk factors for ischemic stroke and coronary heart disease. MR-Egger intercepts provided no evidence of directional pleiotropy. The MR-PRESSO and leave-one-out analyses did not indicate any outlier instruments.Conclusion: Our MR study does not support a causal association of genetically predicted AD with ischemic stroke, large artery stroke, cardioembolic stroke, small vessel stroke, coronary heart disease, and myocardial infarction.
Expression profiles and functions of ferroptosis-related genes in intimal hyperplasia induced by carotid artery ligation in mice
Authors: Zhang Lina , Li Wei , Shi Bo , Zhang Xiaoqing , Gong Kaizheng 
Published: August 2022

Intimal hyperplasia (IH) is a prominent pathological event that occurs during in-stent restenosis and atherosclerosis. Ferroptosis, characterized by iron-dependent and lipid peroxidation, has become the recent focus of studies on the occurrence and progress of cardiovascular diseases. However, there are few studies on ferroptosis and IH. Therefore, we aimed to identify and validate ferroptosis-related markers in IH to explore new possibilities for IH diagnosis and treatment. The IH microarray dataset (GSE182291) was downloaded from the Gene Expression Omnibus (GEO) database and ferroptosis-related genes (FRGs) were obtained from the FerrDb databases. The differentially expressed genes (DEGs) were analyzed using the GEO2R. Overlapping was performed to identify the ferroptosis-related DEGs among the DEGs and FRGs. Then, clustering, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and protein–protein interaction (PPI) analyses were performed. Subsequently, the hub genes were identified using Cytoscape and hub gene–transcription factors and hub gene–microRNA networks were constructed. Finally, real-time qPCR (RT-qPCR) and immunohistochemistry (IHC) were used to verify the mRNA and protein levels of the hub FRGs in IH. Thirty-four FRGs showing significantly different expression were identified from a total of 1,197 DEGs 2 days after ligation; 31 FRGs were selected from a total of 1,556 DEGs 14 days after ligation. The GO and KEGG analyses revealed that these 34 ferroptosis-related DEGs identified 2 days after ligation were mainly enriched in the basolateral plasma membrane, ferroptosis, lipid and atherosclerosis, and IL-17 signaling pathways. The 31 ferroptosis-related DEGs in endometrial hyperplasia identified 14 days after ligation were mainly enriched in response to oxidative stress, ferroptosis, tumor necrosis factor signaling pathway, and lipid and atherosclerosis. Five hub FRGs (Il1b, Ptgs2, Cybb, Cd44, and Tfrc) were identified using PPI networks; four hub FRGs (Il1b, Ptgs2, Cybb, and Cd44) were validated to be upregulated 2 and 14 days after ligation using RT-qPCR and show significantly different expression 14 days after ligation via IHC. Our findings verify the expression of hub DEGs related to ferroptosis in IH and elucidate the potential relationship between ferroptosis and IH, providing more evidence about the vital role of ferroptosis in IH.
Identification of SLAMF1 as an immune-related key gene associated with rheumatoid arthritis and verified in mice collagen-induced arthritis model
Authors: Li Anqi , Zhang Zhanfeng , Ru Xiaochen , Yi Yanfeng , Li Xiaoyu , Qian Jing , Wang Jue , Yang Xiaobing , Yao Yunliang 
Published: August 2022

BackgroundRheumatoid arthritis (RA) is the most common inflammatory arthropathy. Immune dysregulation was implicated in the pathogenesis of RA. Thus, the aim of the research was to determine the immune related biomarkers in RA.MethodsWe downloaded the gene expression data of RA in GSE89408 and GSE45291 from Gene Expression Omnibus public database (GEO). Differentially expressed genes (DEGs) were identified between RA and control groups. Infiltrating immune cells related genes were obtained by ssGSEA and weighted gene co-expression network analysis (WGCNA). We performed functional enrichment analysis of differentially expressed immunity-related genes (DEIRGs) by “clusterProfiler” R package, key genes screening by protein-protein interaction (PPI) network of DEIRGs. And mice collagen-induced arthritis (CIA) model was employed to verify these key genes.ResultsA total of 1,885 up-regulated and 1,899 down-regulated DEGs were identified in RA samples. The ssGSEA analysis showed that the infiltration of 25 cells was significantly different. 603 immune related genes were obtained by WGCNA, and 270 DEIRGs were obtained by taking the intersection of DEGs and immune related genes. Enrichment analyses indicated that DEIRGs were associated with immunity related biological processes. 4 candidate biomarkers (CCR7, KLRK1, TIGIT and SLAMF1) were identified from the PPI network of DEIRGs and literature research.In mice CIA model, the immunohistochemical stain showed SLAMF1 has a significantly high expression in diseased joints. And flow cytometry analysis shows the expression of SLAMF1 on CIA mice-derived CTL cells, Th, NK cells, NKT cells, classical dendritic cell (cDCs) and monocytes/macrophages was also significantly higher than corresponding immune cells from HC mice.ConclusionOur study identified SMLAF1 as a key biomarker in the development and progression of RA, which might provide new insight for exploring the pathogenesis of RA.
Perioperative inappropriate red blood cell transfusions significantly increase total costs in elective surgical patients, representing an important economic burden for hospitals
Authors: Saporito Andrea , La Regina Davide , Hofmann Axel , Ruinelli Lorenzo , Merler Alessandro , Mongelli Francesco , Trentino Kevin M. , Ferrari Paolo 
Published: August 2022

BackgroundRed blood cell (RBC) transfusions in surgical patients are associated with increased morbidity a hospital stay. However, little is known about how clinical and economic outcomes differ between appropriately and inappropriately transfused patients. We hypothesized that inappropriate RBC transfusions in elective surgical patients would significantly increase hospital cost. The aim of this study was to quantify the economic burden associated with inappropriate RBC transfusions.MethodsWe retrospectively included all adult patients admitted for elective non-cardiac surgery between January 2014 and March 2020. Patients were divided into three groups (not transfused, appropriately transfused and inappropriately transfused). The primary outcome was the excess in hospital cost in patients inappropriately transfused compared to non-transfused patients. Costs were calculated using a bottom–up approach and involving cost calculation on a granular level. According to international guidelines, transfusions were considered appropriate if administered with an ASA score of 1–2 and the last hemoglobin level measured before transfusion &lt; 70 g/L, or with an ASA score ≥ 3 and the last hemoglobin level &lt; 80 g/L. Cases where RBC transfusions were deemed necessary regardless of the Hb levels were reviewed by the patient blood management (PBM) board and classified accordingly. Secondary outcomes included total transfusion rate, transfusion index, and length of hospital stay. Statistical analysis was carried out by multivariable regression models.ResultsDuring the study period there were 54,922 consecutive surgical admissions, of these 1,997 received an RBC transfusion, with 1,125 considered inappropriate. The adjusted cost of each inappropriate RBC transfusions was estimated in United States dollars (USD) 9,779 (95% CI, 9,358 – 10,199; p &lt; 0.001) and totaled USD 11,001,410 in our series. Inappropriately transfused patients stayed 1.6 times (95% CI, 1.5–1.6; p &lt; 0.001) longer in hospital (10.6 days vs. 6.7 days) than non-transfused patients and a mean 2.35 RBC units per patient were administered.ConclusionInappropriate RBC transfusions in elective surgical patients seem to be common and may represent a significant economic burden. In our experience, inappropriate transfusions significantly increased hospital costs by an average of USD 9,779 compared to non-transfused patients. Through specific PBM policy, hospitals may improve cost-effectiveness of their elective surgical activity by lowering inappropriate transfusions.