bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prematuridade extrema em uma unidade pública de referência: morbidade, viabilidade e mortalidade
Authors: Laranjeira Patrícia Fabiane Monteiro , Santos Vanessa de Carla Batista dos , Nogueira Janaína da Silva , Laranjeira Ana Clara Monteiro , Amorim Gabriel Monteiro , Laranjeira Rafael Monteiro , Barbosa Kevan Guilherme Nóbrega 
Published: May 2022

O nascimento prematuro é um problema de saúde pública, pela elevada mortalidade e pelo risco de deficiências graves ao longo da vida. O objetivo foi avaliar a morbidade e a mortalidade numa maternidade de alto risco e conhecer o limiar de viabilidade. A amostra foi selecionada em quatro estágios: identificação, seleção, estratificação dos prematuros por idade gestacional e peso de nascimento e preenchimento de formulário estruturado. Foram avaliados neonatos até 31 semanas que tiveram desfecho óbito, no período de agosto de 2015 a agosto de 2020, através de levantamento retrospectivo, baseado na análise descritiva de variáveis relacionadas à gestação, ao parto e ao recém-nascido. Foram descritos percentuais absolutos e relativos para as variáveis categóricas e cálculo de média, mediana e desvio-padrão, valor mínimo e máximo para as quantitativas contínuas. A maioria dos neonatos tinha baixa idade gestacional (56,3%), extremo baixo peso (39,8%) e sofreu asfixia (38,7%). As principais morbidades foram a síndrome do desconforto respiratório (100%) e a sepse (40,6%). O óbito atingiu 55,9% dos prematuros extremos. A mortalidade variou de 26% com 31 semanas a 100% com 22 semanas, a maioria (56,3%) entre 22 e 27 semanas. Dos 266 óbitos, 25 (9,3%) ocorreram na sala de parto e 237 (89%), na unidade neonatal. O índice de mortalidade precoce foi de 0,77 óbitos por 1.000 nascidos-vivos e o tardio, de 0,22 óbitos por 1.000 nascidos-vivos. O limite de viabilidade encontrado foi de 28 semanas. O óbito, além das características fetais, sofreu a influência de uma série de fatores passíveis de intervenção.
Aspectos clínicos e anatômicos do situs inversus: uma revisão integrativa de literatura
Authors: Nascimento Samila Carla da Silva , Figueiredo Bárbara Queiroz de , Matos Bruna Alves de , Carvalho Giovanna Ribeiro Amaral de , Lima Maria Fernanda Londe de 
Published: May 2022

Introdução: o situs inversus é uma anomalia congênita rara caracterizada pela transposição dos órgãos abdominais, vísceras e vasculatura, em relação ao sentido sagital, oferecendo uma imagem chamada de “imagem no espelho”. Classifica-se como total quando associada à dextrocardia, enquanto o situs inversus parcial afeta apenas um ou mais órgãos. Objetivo: responder quais as evidências sobre os aspectos clínicos e anatômicos do situs inversus. Metodologia: trata-se de uma revisão integrativa de literatura. A pesquisa foi realizada através do acesso online nas bases de dados National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (Scielo), Cochrane Database of Systematic Reviews (CDSR), Google Scholar, Biblioteca Virtual em Saúde (BVS) e EBSCO Information Services Resultados e discussão: no situs solitus, o pulmão direito tem três lóbulos e um brônquio eparterial (brônquios acima da artéria pulmonar), enquanto o pulmão esquerdo tem dois lóbulos com um brônquio hiparterial (brônquios abaixo da artéria pulmonar), o estômago e o baço estão à esquerda e o lobo maior do fígado está à direita. O átrio esquerdo morfológico é à esquerda do átrio morfológico direito. Com o situs inversus, o pulmão esquerdo tem três lóbulos com um brônquio eparterial e o pulmão direito tem dois lóbulos com um brônquio hiparterial, o estômago e o baço estão no lado direito do corpo, o lobo maior do fígado está à esquerda, e o átrio esquerdo morfológico é à direita do átrio morfológico direito. Considerações finais: sabe-se que essa assimetria anatômica é estabelecida durante a formação embrionária, especificamente, na rotação dos órgãos. Entretanto, vale ressaltar que os indivíduos portadores do situs inversus total por si só não apresentam repercussões clínicas, com exceção dos casos associados a cardiopatias. Assim sendo, quase sempre, o seu diagnóstico é um achado em exames de imagem, como radiografias, tomografias e ultrassonografias.
Consumo de álcool, nível de atividade física e composição corporal de praticantes de caminhada recreativa
Authors: Oliveira David Michel de , Fernandes Eduardo Vignoto , Silva Ana Flavia Andalecio Couto da , Xavier Alex de Souza , Silva Luiz Fernando Gouvêa e , Pêssoa Filho Dalton Miller 
Published: May 2022

Objetivo: analisar o consumo de álcool, nível de atividade física (NAF) e a composição corporal (CC) em praticantes de caminhada recreativa. Métodos: Participaram do estudo 125 mulheres e 148 homens com idade média de idade de 37,4 ± 12,8 e 40,0 ± 13,8 anos, respectivamente. Foram avaliados o perfil do consumo de álcool pelo Alcohol Use Disorder Identification Test, o NAF pelo International Physical Activity Questionnaire-Short Form (IPAQ-SF), para a CC coletou-se a massa corporal (MC), estatura, e calculou-se o índice de massa corpórea (IMC), e mensurada a circunferência abdominal (CA). Aplicou-se estatística descritiva e inferencial, adotando-se p<0,05. Resultados: Houve associação (p = 0,04), os homens apresentam 3,16 vezes mais chances de risco de consumo que as mulheres. 82,4% das mulheres e 72,3% dos homens classificou-se como fisicamente ativos. A CA apresentou associação (p = 0,02), as mulheres tiveram um risco metabólico 1,75 vezes maior. Quando comparado por faixas etárias, as mulheres de meia idade exibiam MC (p = 0,02), IMC (p < 0,001) e CA (p < 0,0001) superiores as mulheres jovens. Nos homens de meia idade (p = 0,0002) e idosos (p = 0,002) foi identificado CA mais elevada que os homens jovens. Conclusão: Os homens jovens apresentaram risco elevado de consumo alcoólico. Em geral a população foi classificada com baixo risco para o consumo de álcool e fisicamente ativa. Embora a maioria da população não jovem tenha sido identificada com CC indesejável, os resultados reforçam que AF pode ser utilizada como uma estratégia para hábitos saudáveis.
Identity integration in Steven Spielberg’s Catch Me If You Can (2002)
Authors: Apriyanto Rizky 
Published: May 2022

This article aims at analyzing the types of identity integration in Steven Spielberg's Catch Me If You Can movie (2002). It reveals the psychological disorder that caused the main character to have several identities in the movie. Identity is a complex matter nowadays, and it has become one of the most discussed issues. The main character discussed in this article is Frank William Abagnale Jr., a promising young man with complex issues in his family. As a result, Frank's psychological disorder was caused by several problems during his adolescence. By using the psychological theory developed by Erik Erikson (1902), and the cinematographic language developed by Warren Buckland (1966) and Timothy Heiderich, the study is a psychoanalytic analysis. The analysis shows some results, that Frank William Abagnale Jr. is having a psychological disorder. His symptoms of being disintegration in his identity is mainly because he was having a family issue during his adolescence, which results in his future. He has to overcome his being disintegration by impersonating others’ identities. Thus, as a main character in the movie, Frank William Abagnale Jr. is an insane character since he earns millions of dollars before he reaches nineteen.
Using Machine Learning Techniques to Develop Risk Prediction Models for the Risk of Incident Diabetic Retinopathy Among Patients With Type 2 Diabetes Mellitus: A Cohort Study
Authors: Zhao Yuedong , Li Xinyu , Li Shen , Dong Mengxing , Yu Han , Zhang Mengxian , Chen Weidao , Li Peihua , Yu Qing , Liu Xuhan , Gao Zhengnan 
Published: May 2022

ObjectiveTo construct and validate prediction models for the risk of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus.MethodsPatients with type 2 diabetes mellitus hospitalized over the period between January 2010 and September 2018 were retrospectively collected. Eighteen baseline demographic and clinical characteristics were used as predictors to train five machine-learning models. The model that showed favorable predictive efficacy was evaluated at annual follow-ups. Multi-point data of the patients in the test set were utilized to further evaluate the model’s performance. We also assessed the relative prognostic importance of the selected risk factors for DR outcomes.ResultsOf 7943 collected patients, 1692 (21.30%) developed DR during follow-up. Among the five models, the XGBoost model achieved the highest predictive performance with an AUC, accuracy, sensitivity, and specificity of 0.803, 88.9%, 74.0%, and 81.1%, respectively. The XGBoost model’s AUCs in the different follow-up periods were 0.834 to 0.966. In addition to the classical risk factors of DR, serum uric acid (SUA), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), estimated glomerular filtration rate (eGFR), and triglyceride (TG) were also identified to be important and strong predictors for the disease. Compared with the clinical diagnosis method of DR, the XGBoost model achieved an average of 2.895 years prior to the first diagnosis.ConclusionThe proposed model achieved high performance in predicting the risk of DR among patients with type 2 diabetes mellitus at each time point. This study established the potential of the XGBoost model to facilitate clinicians in identifying high-risk patients and making type 2 diabetes management-related decisions.
Artificial Intelligence for the Estimation of Visual Acuity Using Multi-Source Anterior Segment Optical Coherence Tomographic Images in Senile Cataract
Authors: Ahn Hyunmin , Jun Ikhyun , Seo Kyoung Yul , Kim Eung Kweon , Kim Tae-im 
Published: May 2022

PurposeTo investigate an artificial intelligence (AI) model performance using multi-source anterior segment optical coherence tomographic (OCT) images in estimating the preoperative best-corrected visual acuity (BCVA) in patients with senile cataract.DesignRetrospective, cross-instrument validation study.SubjectsA total of 2,332 anterior segment images obtained using swept-source OCT, optical biometry for intraocular lens calculation, and a femtosecond laser platform in patients with senile cataract and postoperative BCVA ≥ 0.0 logMAR were included in the training/validation dataset. A total of 1,002 images obtained using optical biometry and another femtosecond laser platform in patients who underwent cataract surgery in 2021 were used for the test dataset.MethodsAI modeling was based on an ensemble model of Inception-v4 and ResNet. The BCVA training/validation dataset was used for model training. The model performance was evaluated using the test dataset. Analysis of absolute error (AE) was performed by comparing the difference between true preoperative BCVA and estimated preoperative BCVA, as ≥0.1 logMAR (AE≥0.1) or &lt;0.1 logMAR (AE&lt;0.1). AE≥0.1was classified into underestimation and overestimation groups based on the logMAR scale.Outcome MeasurementsMean absolute error (MAE), root mean square error (RMSE), mean percentage error (MPE), and correlation coefficient between true preoperative BCVA and estimated preoperative BCVA.ResultsThe test dataset MAE, RMSE, and MPE were 0.050 ± 0.130 logMAR, 0.140 ± 0.134 logMAR, and 1.3 ± 13.9%, respectively. The correlation coefficient was 0.969 (p&lt; 0.001). The percentage of cases with AE≥0.1was 8.4%. The incidence of postoperative BCVA &gt; 0.1 was 21.4% in the AE≥0.1group, of which 88.9% were in the underestimation group. The incidence of vision-impairing disease in the underestimation group was 95.7%. Preoperative corneal astigmatism and lens thickness were higher, and nucleus cataract was more severe (p&lt; 0.001, 0.007, and 0.024, respectively) in AE≥0.1than that in AE&lt;0.1. The longer the axial length and the more severe the cortical/posterior subcapsular opacity, the better the estimated BCVA than the true BCVA.ConclusionsThe AI model achieved high-level visual acuity estimation in patients with senile cataract. This quantification method encompassed both visual acuity and cataract severity of OCT image, which are the main indications for cataract surgery, showing the potential to objectively evaluate cataract severity.
The Gut Microbiome in Parkinson’s Disease: A Longitudinal Study of the Impacts on Disease Progression and the Use of Device-Assisted Therapies
Authors: Lubomski Michal , Xu Xiangnan , Holmes Andrew J. , Muller Samuel , Yang Jean Y. H. , Davis Ryan L. , Sue Carolyn M. 
Published: May 2022

BackgroundAltered gut microbiome (GM) composition has been established in Parkinson’s disease (PD). However, few studies have longitudinally investigated the GM in PD, or the impact of device-assisted therapies.ObjectivesTo investigate the temporal stability of GM profiles from PD patients on standard therapies and those initiating device-assisted therapies (DAT) and define multivariate models of disease and progression.MethodsWe evaluated validated clinical questionnaires and stool samples from 74 PD patients and 74 household controls (HCs) at 0, 6, and 12 months. Faster or slower disease progression was defined from levodopa equivalence dose and motor severity measures. 19 PD patients initiating Deep Brain Stimulation or Levodopa-Carbidopa Intestinal Gel were separately evaluated at 0, 6, and 12 months post-therapy initiation.ResultsPersistent underrepresentation of short-chain fatty-acid-producing bacteria, Butyricicoccus, Fusicatenibacter, Lachnospiraceae ND3007 group, and Erysipelotrichaceae UCG-003, were apparent in PD patients relative to controls. A sustained effect of DAT initiation on GM associations with PD was not observed. PD progression analysis indicated that the genus Barnesiella was underrepresented in faster progressing PD patients at t = 0 and t = 12 months. Two-stage predictive modeling, integrating microbiota abundances and nutritional profiles, improved predictive capacity (change in Area Under the Curve from 0.58 to 0.64) when assessed at Amplicon Sequence Variant taxonomic resolution.ConclusionWe present longitudinal GM studies in PD patients, showing persistently altered GM profiles suggestive of a reduced butyrogenic production potential. DATs exerted variable GM influences across the short and longer-term. We found that specific GM profiles combined with dietary factors improved prediction of disease progression in PD patients.
Cerebral Blood Flow and Other Predictors of Responsiveness to Erenumab and Fremanezumab in Migraine—A Real-Life Study
Authors: Nowaczewska Magdalena , Straburzyński Marcin , Waliszewska-Prosół Marta , Meder Grzegorz , Janiak-Kiszka Joanna , Kaźmierczak Wojciech 
Published: May 2022

IntroductionMonoclonal antibodies (mAbs) showed efficacy in migraine prevention. The aim of this study was to check if baseline clinical parameters and cerebral blood flow (CBF) measured by transcranial Doppler (TCD) may help predict mAbs efficacy.MethodsElectronic charts of migraineurs treated with erenumab or fremanezumab, with baseline TCD evaluations were collected, including data on migraine type, pain localization, monthly migraine days (MMD), medication overuse headache (MOH), mean blood flow velocity (Vm), and pulsatility index (PI) in cerebral arteries.ResultsA total of 123 patients were enrolled, mean age 38, 75 years, 87 with chronic migraine, 61 with MOH, 72 were good responders (GR), and reported ≥50% reduction in MMD, 43 ≥75% reduction in MMD. Baseline Vm values in MCAs were significantly lower in GR as compared with non-responders. MAbs responsiveness ≥50% was positively associated with unilateral pain localization (OR: 6.53, 95% CI: 2.01–23.93; p = 0.003) and HIT-6 score (OR: 1.14, 95% CI: 1.01–1.30; p = 0.036) whereas negatively associated with Vm in right MCA (OR: 0.96, 95% CI: 0.92–0.99; p = 0.012), and having no relatives with migraine (OR: 0.40, 95% CI: 0.16–0.95; p = 0.040).ConclusionsBaseline Vm in MCA is lower in mAbs GR as compared with non-responders which may reflect increased secretion of CGRP with further vasodilation in GR. Simple clinical features and baseline CBF in anterior circulation might help to predict the patient's responsiveness.
Pediatric Responses to Fundamental and Formant Frequency Altered Auditory Feedback: A Scoping Review
Authors: Coughler Caitlin , Quinn de Launay Keelia L. , Purcell David W. , Oram Cardy Janis , Beal Deryk S. 
Published: May 2022

PurposeThe ability to hear ourselves speak has been shown to play an important role in the development and maintenance of fluent and coherent speech. Despite this, little is known about the developing speech motor control system throughout childhood, in particular if and how vocal and articulatory control may differ throughout development. A scoping review was undertaken to identify and describe the full range of studies investigating responses to frequency altered auditory feedback in pediatric populations and their contributions to our understanding of the development of auditory feedback control and sensorimotor learning in childhood and adolescence.MethodRelevant studies were identified through a comprehensive search strategy of six academic databases for studies that included (a) real-time perturbation of frequency in auditory input, (b) an analysis of immediate effects on speech, and (c) participants aged 18 years or younger.ResultsTwenty-three articles met inclusion criteria. Across studies, there was a wide variety of designs, outcomes and measures used. Manipulations included fundamental frequency (9 studies), formant frequency (12), frequency centroid of fricatives (1), and both fundamental and formant frequencies (1). Study designs included contrasts across childhood, between children and adults, and between typical, pediatric clinical and adult populations. Measures primarily explored acoustic properties of speech responses (latency, magnitude, and variability). Some studies additionally examined the association of these acoustic responses with clinical measures (e.g., stuttering severity and reading ability), and neural measures using electrophysiology and magnetic resonance imaging.ConclusionFindings indicated that children above 4 years generally compensated in the opposite direction of the manipulation, however, in several cases not as effectively as adults. Overall, results varied greatly due to the broad range of manipulations and designs used, making generalization challenging. Differences found between age groups in the features of the compensatory vocal responses, latency of responses, vocal variability and perceptual abilities, suggest that maturational changes may be occurring in the speech motor control system, affecting the extent to which auditory feedback is used to modify internal sensorimotor representations. Varied findings suggest vocal control develops prior to articulatory control. Future studies with multiple outcome measures, manipulations, and more expansive age ranges are needed to elucidate findings.
Neuroblastic Tumors of the Adrenal Gland in Elderly Patients: A Case Report and Review of the Literature
Authors: Deslarzes Philip , Djafarrian Reza , Matter Maurice , La Rosa Stefano , Gengler Carole , Beck-Popovic Maja , Zingg Tobias 
Published: May 2022

BackgroundNeuroblastic neoplasms (NN) include ganglioneuromas (GN), ganglioneuroblastomas (GNB), and neuroblastomas (NB). They generally arise in childhood from primitive sympathetic ganglion cells. Their incidence in adults, especially among elderly, is extremely low.Case PresentationThis is the case of a 74-year-old woman with history of abdominal pain, weakness and night sweating since several months. Blood pressure was normal. CT-scan showed a 10 cm left adrenal mass, without other pathologic findings. An open left-sided adrenalectomy was performed. Recovery was uneventful with hospital length of stay of 8 days. Based on morphological, immunohistochemical, and molecular features the diagnosis was a nodular GNB. A positron emission tomography (PET) performed 6 weeks after the resection did not show any residual tumor or distant metastases. The patient was followed-up with annual clinical and radiological exams.ConclusionThis case presentation, associated with a review of the literature, illustrates the importance to include NN in the preoperative differential diagnosis of adrenal tumors in adults and highlights the need for multidisciplinary patient work-up and management.
Taking Care of Business in a Male – Dominated Drug Economy: Income Strategies, Risks, and Opportunities of Women Who Use Drugs
Authors: Richert Torkel 
Published: May 2022

BackgroundStreet level drug economies are often described as hierarchical and gender-segregated arenas where men hold high positions and control the supply of drugs, and where women are confined to marginal and low-level positions. Few studies have explored income strategies, risks and opportunities of women who use drugs within drug economies in the Nordic countries.ObjectiveThe aim of this study was to analyze women's stories about “taking care of business”–making money and securing drugs–in a local drug economy. The study focuses on the women's gender enactments, the strategies they use to achieve success, and the barriers and risks they face in their everyday endeavors.MethodsThis article draws on informal conversations and in-depth qualitative interviews with 27 female drug users in Malmö, Sweden during periods of fieldwork between 2009 and 2012.ResultsThe interviewed women had established themselves as entrepreneurs in the local drug economy, working hard for their money. However, only a few held middle or high positions, and all women described encountering gendered obstacles and risks in their efforts to take care of business. The patriarchal and sexualized nature of the drug economy meant special prerequisites for the women's income strategies and gender enactments. Three main income strategies were distinguished in the women's stories: (1) using femininity and sexuality, (2) proving tough and dangerous by using street masculinity, and (3) establishing trust, being professional, and keeping a low profile. These strategies involved different advantages and disadvantages, as well as different types of risk.ConclusionsThe results show that it is possible for women to achieve success in male-dominated drug economies, but that this is associated with major challenges. Gendered social hierarchies, structures and norms seem to influence the women's gender enactments, opportunities and risks. However, factors such as type of drug use, degree of drug dependence and social position, was also decisive for their possibility of taking care of business. This points to the importance of combining a focus on gender with a focus on other determants of power relations and vulnerabilities, when studying the everyday lives of people who use drugs.