bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simple suture whipstitch closure is a reasonable option for many patients requiring temporary abdominal closure for blunt or penetrating trauma
Authors: Collins Reagan , Dhanasekara Chathurika Samudani , Morris Erin , Marschke Brianna , Dissanaike Sharmila 
Published: October 2022

ObjectivesMultiple temporary abdominal closure (TAC) techniques are currently used to manage the open abdomen (OA) in severely injured trauma patients, with variability in efficacy and cost. We evaluated the clinical outcomes of two commonly used TAC methods: ABTHERA Negative Pressure Therapy System and whipstitch suture closure (WC).MethodsWe conducted a retrospective review of patients who had blunt or penetrating trauma from 2015 to 2021 with OA managed using either ABTHERA, WC, or both. Primary outcomes included overall and intensive care unit length of stay, ventilator days, number of laparotomies, time to definitive fascial closure, and complications (bleeding, evisceration, wound dehiscence, and reoperation). Univariate and multivariate analyses were used to compare baseline characteristics, outcomes, and complications. Potential mediators of the relationship between the type of TAC and outcomes were explored using mediation analyses.ResultsA total of 112 TAC were analyzed; 86 patients had a single type of TAC placement (either WC or ABTHERA), whereas 26 had both types. A majority of patients had blunt trauma in both WC (77%) and ABTHERA (76%) cohorts. There were no differences in baseline characteristics, including injury severity (27.5±12.4 and 27.5±12.0 for ABTHERA and WC, respectively). There was no statistically significant difference among individual complications and overall complications (OR=0.622 (0.274 to 1.412)). No differences were found between the outcomes, and any apparent differences seen were mediated by factors such as a higher number of laparotomies.ConclusionWC is a low-cost option for TAC in trauma, with similar clinical outcomes and complications to ABTHERA.Level of evidenceLevel III therapeutic/care management study.
The effects of extrusion on nutrient content of Canadian pulses with a focus on protein and amino acids
Authors: Cargo-Froom Cara L. , Newkirk Rex W. , Marinangeli Christopher P.F. , Shoveller Anna K. , Ai Yongfeng , Columbus Daniel A. 
Published: October 2022

Alternative sources of protein will be required in both human and animal nutrition to support ingredient sustainability and nutrient demands of a growing world population. Extrusion is one technique utilized to process pulses and is reported to increase starch and protein digestibility but also has the potential to transform nutrients into non-nutritious compounds. This study sought to compare the effects of extrusion on nutrient composition in Amarillo peas, Dun peas, lentils, chickpeas, and faba beans, with soybean meal (control). Each pulse was extruded at 18% or 22% moisture and 110, 130, or 150 °C. Compared to whole samples, extrusion increased crude protein content of Amarillo and Dun peas, and lentils, and it decreased in soybean meal ( P < 0.05). Compared with whole samples, extrusion increased methionine content in chickpeas and lentils ( P < 0.05), with no effect in Amarillo or Dun peas, faba beans, and soybean meal. Cysteine content increased in extruded Amarillo peas compared with whole pulses, and decreased in soybean meal ( P < 0.05). Results suggest that extrusion can positively affect protein and amino acid content of pulses, however, specific changes differ by pulse/legume type.
Complexity analysis of heartbeat-related signals in brain MRI time series as a potential biomarker for ageing and cognitive performance
Authors: López Pérez David , Bokde Arun L. W. , Kerskens Christian M. 
Published: October 2022

AbstractGetting older affects both the structure of the brain and some cognitive capabilities. Until now, magnetic resonance imaging (MRI) approaches have been unable to give a coherent reflection of the cognitive declines. It shows the limitation of the contrast mechanisms used in most MRI investigations, which are indirect measures of brain activities depending on multiple physiological and cognitive variables. However, MRI signals may contain information of brain activity beyond these commonly used signals caused by the neurovascular response. Here, we apply a zero-spin echo (ZSE) weighted MRI sequence, which can detect heartbeat-evoked signals (HES). Remarkably, these MRI signals have properties only known from electrophysiology. We investigated the complexity of the HES arising from this sequence in two age groups; young (18–29 years) and old (over 65 years). While comparing young and old participants, we show that the complexity of the HES decreases with age, where the stability and chaoticity of these HES are particularly sensitive to age. However, we also found individual differences which were independent of age. Complexity measures were related to scores from different cognitive batteries and showed that higher complexity may be related to better cognitive performance. These findings underpin the affinity of the HES to electrophysiological signals. The profound sensitivity of these changes in complexity shows the potential of HES for understanding brain dynamics that need to be tested in more extensive and diverse populations with clinical relevance for all neurovascular diseases.
Berberine Attenuates Hyperuricemia by Regulating Urate Transporters and Gut Microbiota
Authors: Shan Baixi , Wu Mingyu , Chen Ting , Tang Weiwei , Li Ping , Chen Jun 
Published: October 2022

Hyperuricemia (HUA) and its associated metabolic diseases seriously threaten human health, and commensal microbiota has been identified as one of the environmental triggers of HUA. The role of berberine (BBR) in the treatment of HUA has begun to receive attention in recent years. However, how BBR modulates the microbiota to slow HUA progression is unclear. In this study, we showed that BBR alleviated potassium oxonate (PO)-induced HUA in mice by suppressing the expression of xanthine oxidase (XOD) in the liver and urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) in the kidney. The BBR also improved renal inflammation by inhibiting the expression of TNF-[Formula: see text], IL-1[Formula: see text], and caspase-1. Subsequently, we evaluated whether the observed anti-HUA effects of BBR were associated with changes in gut microbial structure in mice. 16S rRNA sequencing data showed that BBR significantly altered the community compositional structure of the gut microbiota. Specifically, BBR enriched the abundance of Coprococcus, Bacteroides, Akkermansia, and Prevotella. Antibiotic treatment can reverse the anti-HUA effects of BBR that further supports the role of the gut microbiota. In conclusion, our study provides evidence that BBR ameliorates PO-induced HUA by modulating the gut microbiota.
Penetration of renewable sources through solar systems: a case study Kosovo
Authors: Bylykbashi Blerina , Hoxha Bukurije 
Published: October 2022

This paper analyzes the potential of solar energy and the efficiency of a solar system for real measurements. During the analysis, one-year radiation measurements for the city of Pristina were used. Analyzes show a high potential for exploitation. What affects the increase of efficiency of such systems is the possibility of use throughout the year. For each respective month is shown the potential of thermal energy that can be achieved and efficiency. The paper highlights the role of solar energy in maximizing the penetration of renewable sources. The analysis shows that in August the coverage of the needs for hot sanitary water from the proposed solar system is 99% and minimally in January by 16%. Taking into account the seasonal changes that apply to the country, I consider that a possible combination of central heating systems with those of sanitary water - solar system would be an adequate solution.
TransHuman Saunter:Multispecies Storytelling in Precarious Times
Authors: Gonsalves Kavita , Aia-Fa’aleava Agapetos , Thanh Ha Lan , Junpiban Naputsamohn , Narain Natasha , Foth Marcus , Caldwell Glenda Amayo 
Published: October 2022

AbstractTransHuman Saunter is a geolocative artwork that documents the entanglements of four women artists of color with the multispecies ecosystem of the Indian banyan tree in Brisbane City Botanic Gardens, Australia. The work positions itself during a time when the impacts of capitalism and colonialism are evident in the planetary crisis of climate change and species loss in addition to a pandemic that exacerbates ethno-racial and gender inequity. This artists’ article covers the rationale of the work and its methodology and describes the individual artworks. It serves as an act of pluralistic storytelling of unheard voices situated in place.
The Politics of Visual Indeterminacy in Abstract AI Art
Authors: Zeilinger Martin 
Published: October 2022

AbstractIn Perception Engines and Synthetic Abstractions, two generative AI art projects begun in 2018, Tom White experiments with visual abstraction to explore the indeterminacy of perception, interpretation, and agency. White’s AI systems produce images that will be interpreted as abstract artworks by human viewers, but which also confront human audiences with the realization that what is here deliberately rendered indeterminable for them will remain near-perfectly legible for AI-powered image recognition systems. This difference in perceptual and interpretive agency foregrounds an underlying politics of visual indeterminacy. White’s projects thus increase awareness of how machine vision—for example in automated online filtering systems—can diminish the horizon of what human audiences can or cannot see in an AI-driven digital cultural landscape, and how, in the process, underlying biases are normalized and human viewers become habituated to the dramatic shrinking of perceivable/viewable online image content mediated by AI.
Experimental Environments and the Aesthetic Experience of Metabolic Processes
Authors: Foerster Desiree , Campbell Iain 
Published: October 2022

AbstractThis article explores the aesthetic experience of metabolic processes in two projects: the newly designed Jade Eco Park in Taiwan, by architect Philippe Rahm, and the virtual reality environment Give and Take, developed by Desiree Foerster, Michaela Büsse, Sarah Hermanutz, and Andreas Rau. The authors argue that a heightened sensitivity to atmospheric and metabolic processes enabled by these projects brings to the foreground a different mode of aesthetic perception, toward how we experience and not only what we feel. They propose further that an aesthetics of metabolism allows us to become more sensitive to our own bodily involvement with the world and other sentient beings with whom humans share the world.
I am _your_Pyrate Dancer: Choreographic Computabilities Dancing inside the Interstices of a Visceral World
Authors: Mauro-Flude Nancy , Pollitt Jo 
Published: October 2022

AbstractThe article proposes that the interstitial as an analytical category advances transdisciplinary developments in contemporary choreographic practice. The techniques and conventions of passing, marking, and parsing are described as concomitant agencies that act as notational scores connected to the informatic procedure of writing as dancing. A case study is provided as an example of how gesture, executable code, computational poetics, script, and syntax can endure beyond the performance event as choreographic score and artifact. The novel application of plain text computing, with all its constraints, not ordinarily connected to terpsichorean practices, paradoxically exhibits a nascent realm in which dance-making futures may endure.
StellarScape: An Immersive Multimedia Performance Inspired by the Life of a Star
Authors: He Yuanyuan (Kay) , Impey Chris , Burleson Winslow 
Published: October 2022

Abstract
StellarScape is an immersive multimedia performance synthesizing music, science, visual art, and technology. The performance includes live musicians, sensors, electronic music, and dance, all collaborating through interactive cinematography The result combines kinesthetic and acoustic sensing with astrophysical simulations of star formation in real time. This convergence research collaboration is catalyzed by the union of concepts at the confluence of astronomy, humanity artistic expression through music and dance, and sociotechnical experience. This article summarizes the authors’ motivation for undertaking the project, the interdisciplinary collaboration required to execute it, the authors’ goals for the audience experience, early results of the first performances, and ways the piece can be delivered in the future for entertainment, outreach, and education.
Plantae Agrestis:Distributed, Self-Organizing Cybernetic Plants in a Botanical Conservatory
Authors: Sareen Harpreet , Kakehi Yasuaki 
Published: October 2022

AbstractConventional digital logic embodied in silicon-based materials has long neglected the capabilities of natural systems. This work seeks to embody a new hybrid form, analogizing chemical signaling to electrical signaling and vice versa. Through an installation at a botanical garden, technological functions in this setting are relegated to plant controls. Several plants are interfaced individually through their own internal signals with robotic extensions and self-organize in a botanical conservatory. The authors observe emergent behavior to consider implications to bioelectronics models, materials, and processes.
Life, Matter, Poetry: Blurred Lines and Bilayered Representations of Materials Science
Authors: Stobie Caitlin E. , Beales Paul A. 
Published: October 2022

Abstract
This article charts the authors’ collaboration resulting from their partnership in the Leeds Creative Labs: Bragg Edition. The authors describe their motivations for working together and the conversations that developed as they discussed artificial life, synthetic matter, and shared terms from the humanities and sciences. They discuss how, after the project was delayed in 2020, they adapted to digital collaboration and secured funding for further outputs, mapping new possibilities for public engagement with materials sciences during the COVID-19 pandemic. In particular, the authors consider the layering of biophysical research images with experimental poems that aim to convey complex yet complementary concepts from philosophy without distorting the underlying scientific data.
Diffractive Rendezvous
Authors: Trudel Gisèle , Czegledy Nina 
Published: October 2022

Abstract
This article is an open-ended discussion of five events from the LASER series hosted at Hexagram in Montreal, Quebec, Canada, between 2014 and 2021. LASERs at Hexagram interweave the research-creations of its members in dialogue with local and international guests. Emerging from the audio-to-text transcriptions of previous documentation of these LASERs, the word “movement” becomes a novel lens of analysis for this text, according to a “diffractive” approach. Thoughts and actions afforded by this word produce a surprisingly gentle yet compelling interdisciplinary weave, to inspire future editions.
Mythical Mushrooms: Hybrid Perspectives on Transcendental Matters
Authors: Yan Xiaojing 
Published: October 2022

Abstract
This paper focuses on the authors artistic practice. She has cultivated a series of evocative sculptural works out of lingzhi fungus by designing a controlled, human environment that, over time, gives way to an organic process. This hybrid bio-art experiment relies as much on science as it does on fate. Lingzhi holds cultural significance in Chinese culture and is called “the mushroom of immortality.” Yan’s works juxtapose Chinese mythology with contemporary culture to highlight environmental and social issues; her investigations with lingzhi mushrooms delve into the meaning of spirituality and metamorphosis and explore questions about being and becoming, art and nature, art and science, nature and existence.
A therapist-supported internet-based intervention for bereaved siblings: A randomized controlled trial
Authors: Wagner Birgit , Hofmann Laura , Maaß Ulrike 
Published: October 2022

Background: The loss of a sibling can have a long-term impact on the mental and physical health of the surviving sibling throughout adolescence and later adulthood. Even though bereaved siblings can be identified as a high-risk group, evidence-based interventions for this bereavement group are still missing. Aim: To evaluate the treatment effects of an internet-based writing intervention for bereaved siblings aged 16–65 years. Design: A two-armed randomized controlled trial (DRKS00011514) compared the intervention to a waiting list control group. The 6-week intervention consisted of six structured writing assignments that were based on cognitive behavioral therapy, focusing on the specific situation of bereaved siblings. Setting/participants: Eighty-six bereaved siblings (loss >1 month ago, no severe psychiatric symptoms) were randomly allocated to the intervention group ( n = 47) or the waiting list control group ( n = 39). Primary outcomes were symptoms of prolonged grief disorder and depression; secondary outcomes were posttraumatic stress symptoms and survivor guilt. Results: Symptoms of depression and prolonged grief disorder improved significantly in the intention-to-treat analyses from pre-to post-measurement compared with the control group ( gDepression = −0.62, gGrief = 0.33). In the intervention group, all primary and secondary outcomes decreased significantly from baseline to 12-month follow-up ( gs = −0.38 to −1.04). A significant clinical change could be found for depression (34%) compared to the waitlist control group (10%). Conclusions: Bereaved siblings profited from this brief internet-based writing intervention in the short- and long-term. However, future research, such as dismantling studies, may help to further optimize the benefits of an intervention aimed at bereaved siblings.
Association between tissue human neutrophil peptide 1–3 levels and cardiovascular phenotype: a prospective, longitudinal cohort study
Authors: Abu Fanne Rami , Arbel Yaron , Chorin Ehud , Maraga Emad , Groisman Gabriel M , Higazi Abd Alroof , Banai Shmuel 
Published: October 2022

Objective Inflammation is associated with atherogenesis. Although a higher neutrophil count is associated with the plaque burden, the role of neutrophil activation is unclear. Human neutrophil peptides 1–3 (HNP1–3) are a risk factor for atherogenesis in bench models and are elevated in human atheromas. This study aimed to examine the association between skin HNP1–3 deposition and the severity of coronary artery disease (CAD), including long-term outcomes. Methods HNP1–3 levels were immunohistochemically quantified in skin biopsies, which were prospectively taken from 599 consecutive patients before clinically indicated coronary angiography. Established cardiovascular risk factors and blood markers for atheroinflammation were obtained. CAD severity and the incidence of repeat revascularization and mortality at 48 months of follow-up were assessed in relation to HNP1–3 levels. Results The risk of CAD was independently associated with age and HNP1–3 in the entire cohort (F = 0.71 and F = 7.4, respectively). Additionally, HNP1–3 levels were significantly associated with myocardial necrosis (R = 0.26). At the follow-up, high HNP1–3 levels negatively affected mortality (19.54%) and recurrent revascularization (8.05%). Conclusion HNP1–3 tissue deposition is positively associated with the severity of CAD, myonecrosis, and long-term sequelae. HNP1–3 levels may be suppressed using colchicine.
The audit market for listed Australian companies from 2012 to 2018: A state of play
Authors: Carson Elizabeth , Fu Yi (Dale) , Thürheimer Ulrike , Xu Yang 
Published: October 2022

Motivated by recent regulatory scrutiny of auditing in Australia, we provide an overview of the audit market for Australian listed companies from 2012 to 2018. Using descriptive analyses, we explore audit market competition, the provision of non-audit services (NAS), and audit firm tenure. We find that the Australian audit market is highly segmented. Big 4 firms increasingly dominate the larger client segment, while Non-Big 4 firms focus on medium and smaller clients. Auditor-provided NAS fees represent a relatively small fraction of audit fees for smaller clients, but a relatively high fraction for larger clients. We further observe that the share of total revenue from NAS of Big 4 firms increases over time. Finally, a relatively small percentage of clients has long audit firm tenure, and that long tenure is more common in the larger client segments. We discuss the implications of these findings and research opportunities that emerge. JEL Classification: D40, L11, M42, L84
The Impact of the COVID-19 Pandemic on Informal Caregivers of People With Parkinson’s Disease Residing in the UK: A Qualitative Study
Authors: Rippon Daniel , Hand Annette , Dismore Lorelle , Caiazza Roberta 
Published: October 2022

Informal caregivers can experience various demands when providing care and support for People with Parkinson’s disease (PwP) in their own homes. The outbreak of SARS-CoV-2 and public health strategies employed to mitigate the spread of COVID-19 have presented challenges to the general populace on a global basis. The present study used a qualitative research design to explore how the COVID-19 pandemic has impacted informal caregivers in their role of providing care for PwP in their own homes. A series of 1:1 semi-structured interviews were conducted with 11 informal caregivers of PwP ( M age = 72.64 years, SD = 8.94 years). A thematic analysis indicated that 1) vulnerabilities to COVID-19, 2) home maintenance & activities of daily living and 3) engagement with healthcare services were 3 themes that provided indications on how the COVID-19 pandemic impacted informal caregivers of PwP. The present study provides illustrations of how being an informal caregiver of PwP and being identified as high risk to COVID-19 can present challenges to the process of caring for loved ones who are also vulnerable to SARS-CoV-2. The results of the present study highlights the necessity to develop strategies to ensure that informal caregivers have the necessary resources to provide care for PwP in their homes and also maintain their own well-being in the post COVID-19 era.