bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology of Injuries in the Radiology Department of a Teaching Hospital
Authors: Eze Joseph C. , Nwodo Victor K. , Ezugwu Emmanuel E. , Agbo Julius A. , Ikechukwu Marvelous C. , Obasi Favour C. 
Published: November 2022

Background: Injury has become a public health problem all over the world, and it is associated with high morbidity and mortality. Objective: This paper focuses on determining the epidemiology of injuries in the Radiology Department of Nnamdi Azikiwe University Teaching Hospital, Nnewi. Method: A retrospective research design was adopted for this study. Request forms of patients were collected from the register in the department. Five hundred and twenty (520) request forms were collected but twenty one (21) were excluded because they did not contain sufficient information needed for the study. The picture and archives communication system (PACS) was also utilized to ensure that information obtained from the register corresponds with the patients who took part within the period of the study. Data was analyzed descriptively using SPSS version 20. Results were presented in frequency tables and percentages. Results: The injuries involved 376 (75.2%) males and 123 (24.8%) females. Road traffic accident accounted for 67.5%, and it was the most occurring injury. Injuries due to fighting accounted for 2 (0.4%), which was the least occurring. Most injuries (18.8%) occurred within the age range of 21-30years, which was closely followed by the age range of 31-40 years (18.2%). Majority of the injuries involved the whole spine (18.5%), which is also followed by chest injuries (18.2%). Conclusion: The injuries recorded involved many body parts and more males than females were affected. Road traffic accident was the major cause of the injuries.
Tanggung Jawab Pejabat Pembuat Akta Tanah Terhadap Karyawan yang Melakukan Perbuatan Pemalsuan Surat Dalam Pembuatan Akta Jual Beli [The Responsibilities of Land Deed Making Officials to Employees who Perform Letter Forgery on the Making of Sale and Purchase Deed]
Authors: Wijaya Irfan , Pandamdari Endang 
Published: November 2022

<p><em>Land Deed Making Officials (PPAT) require employees to assist them in carrying out their duties, but PPAT must also pay attention to every action taken by their employees in carrying out their duties. Additionally, PPAT accuracy must be considered, particularly in the administration of their office. This research discusses PPAT's responsibility for the forgery of letters performed by their employees, and the judge's consideration in the decision on case No. 16/Pid.B/2018/PN.MTR. The author employs a normative juridical research method in this study. The research findings in terms of PPAT's responsibility for employee letter forgery; administrative responsibility, subjected to a sanction of suspended of written warning by head of land office; civil law responsibility, subjected to a sanction caused of unlawful act; criminal responsibility, can’t be charged for responsibility; PPAT must always pay attention to the regulations applicable to their positions to avoid mistakes and sanctions. PPAT supervision and guidance must still be carried out properly in order to build better quality of PPAT.</em></p><p><strong>Bahasa Indonesia Abstrak: </strong>Pejabat Pembuat Akta Tanah (PPAT) memerlukan karyawan untuk membantu menjalankan jabatannya, namun PPAT juga harus memperhatikan setiap tindakan yang dilakukan oleh karyawannya dalam menjalankan pekerjaannya, selain itu juga ketelitian PPAT perlu diperhatikan terutama terhadap administrasi kantornya. Rumusan masalah dalam penelitian ini adalah mengenai pertanggungjawaban PPAT terhadap perbuatan pemalsuan surat yang dilakukan oleh karyawannya; dan pertimbangan hakim dalam Putusan No. 16/Pid.B/2018/PN.MTR. Dalam penelitian ini penulis menggunakan metode penelitian yuridis normatif. Hasil penelitian dalam hal pertanggungjawaban PPAT terhadap perbuatan pemalsuan surat yang dilakukan oleh karyawannya; tanggung jawab secara administrasi dapat dikenakan sanksi teguran tertulis; tanggung jawab secara perdata dapat dibebankan perbuatan melawan hukum atas kelalaian yang mengakibatkan kerugian; tanggung jawab secara pidana tidak dapat dibebankan. Menurut penulis atas kejadian ini, PPAT harus selalu memperhatikan peraturan yang berlaku dalam menjalankan jabatannya agar terhindar dari kesalahan dan sanksi yang berlaku, kemudian adanya pengawasan dan pembinaan terhadap PPAT masih harus dilaksanakan dengan baik guna membangun kualitas PPAT yang lebih baik.</p>
THE RELATIONSHIP BETWEEN BODY SHAMING AND STRESS LEVELS OF THE NINTH-GRADE STUDENTS AT SMPN 4 BOJONEGORO
Authors: Saifudin Moh. , Sholikah Siti , Apreliani Eska Wulan 
Published: November 2022

Introduction: Adolescence is marked by changes in growth and development that occur very rapidly. Adolescents will experience stages towards social and economic independence, identity building, acquisition of skills for adult life, and the ability to negotiate. Body shaming, weight shaming, or harassment based on appearance can be described as mocking or humiliating someone based on their physical appearance. The study aimed to determine the relationship between body shaming behaviour and the stress levels of the ninth graders at SMP N 4 Bojonegoro. Methods: The design of this research was a cross-sectional analysis. The population was 80 ninth graders obtained by using a purposive sampling technique. The students were experiencing body shaming. The research data were taken using the Body-Shaming questionnaire to measure body shaming behaviour and the Depression Anxiety Stress Scale (DASS) 42 questionnaire to measure stress levels. Results: The results showed that 9 out of 11 students (81.8%) who experienced severe body shaming behaviour had extreme stress levels, 37 out of 38 students (97.4%) students who participated in proper body shaming behaviour had moderate stress levels, 18 out of 31 students (58.1%) who experienced mild body shaming behaviour had mild stress levels. Based on the results of the data above, a statistical test was obtained with a significance value of p sign = 0.01 (p <0.05). Conclusions: It can be concluded that there is a relationship between body shaming behaviour and the stress levels of the ninth graders at SMP N 4 Bojonegoro.
Comparative Analysis of Expression of the Main Virulence Genes in Various <i>Vibrio cholerae</i> О1 Strains
Authors: Cheldyshova N. B. , Devdariani Z. L. 
Published: November 2022

The aim of the work was a comparative study of the expression of the main virulence genes in Vibrio cholerae strains of the classical biovar, typical and genetically modified strains of V. cholerae, El Tor biovar.Materials and methods. Natural toxigenic strains of V. cholerae O1, classical biovar (J89, Pakistan, 1969), typical (M-887, Astrakhan, 1970) and genetically modified (301, Taganrog, 2011) strains of the El Tor biovar were used as model ones. The strains were grown under optimum conditions for the production of cholera toxin and toxin-coregulated pili. The assessment of strain growth was carried out in LB broth at room temperature with determination of the cells number on a Biowave DNA spectrophotometer (Biochrome Ltd., UK). Determination of gene expression was performed using real-time PCR with reverse transcription.Results and discussion. The expression of structural (ctxA, tcpA) and regulatory (toxR, toxT, tcpP, tcpH) virulence genes has been investigated in V. cholerae strains of the classical biovar, typical and genetically modified strains of the El Tor biovar. Significant differences have been revealed in terms of time and level of maximum expression of these genes in strains of classical and El Tor biovars. It was found that ctxA and toxR genes expression in the genovariant strain reached its maximum 1–3 h earlier than in the other strains. At the same time, the level of ctxA gene expression corresponded to the level of the classical strain. The maximum expression of the toxR gene in the genovariant strain was higher than in typical El Tor and classical strains, and also had a clear inverse correlation with ctxA gene expression. Expression of the tcpA, toxT, and tcpH genes in the classical biovar strain reached its maximum 1–2 h earlier than in the El Tor biovar strains. These differences should be taken into account when conducting research work related to the study of the expression of the main virulence genes.
Caspian Sandy Natural Focus: Phylogenetic History and Origin of <i>Yersinia pestis</i> Strains
Authors: Goryunova P. A. , Eroshenko G. A. , Kukleva L. M. , Naryshkina E. A. , Sosedova E. A. , Chervyakova N. S. , Kutyrev V. V. 
Published: November 2022

The purpose of the work was to analyze the phylogenetic relations and origin of Yersinia pestis strains isolated in different periods of epizootic activity of the Caspian sandy natural focus (CSNF) of plague in the XX–XXI centuries.Materials and methods. We used 40 Y. pestis strains from CSNF and adjacent plague foci, isolated in 1922–2015. Carried out was whole genome sequencing of 19 Y. pestis strains from CSNF. Phylogenetic analysis was performed using whole genome SNP analysis based on 1914 identified SNPs. The search for marker SNPs was conducted using the Snippy 4.6 software. The phylogenetic tree was constructed using the Maximum Likelihood algorithm, the GTR nucleotide substitution model.Results and discussion. The whole genome SNP analysis has revealed that Y. pestis strains of the medieval biovar from CSNF belong to 2.MED1 phylogenetic lineage and fall into two major branches. One of them circulated in the focus in the first half of the XX century, and the other – in the second half of the XX – early XXI centuries. It is shown that strains of the first branch were the cause of outbreaks and individual cases of plague in the CSNF in the first half of the XX century. They are closely related to strains from the Caspian North-Western steppe and Volga-Ural sandy natural plague foci, which caused numerous outbreaks with high mortality rate in the same period. Y. pestis strains from the CSNF of the second half of the XX and early XXI centuries belong to the second phylogenetic branch of the 2.MED1 line, at the node of which the strains from the Northern Aral Sea region of 1945 lay. The latter were the predecessors of all strains isolated in the CSNF after a long inter-epizootic period that occurred in the middle of the XX century. There can also be traced a genetic relation between the strains from CSNF and the Dagestan plain-foothill focus.
In-Situ Imaging of CO2 Trapping and Oil Recovery in Three-Phase Systems: Dependence on Pore Geometry and Wettability
Authors: Li Yingwen , Yang Yongfei , Dong Mingzhe , Yao Jun , Zhang Kai , Sun Hai , Zhang Lei 
Published: November 2022

SummaryCarbon dioxide (CO2) injection into reservoirs can be combined with enhanced oil recovery. Pore geometry and wettability are critical factors in CO2 trapping and oil recovery. However, their relationship has not been tackled and the influence of wettability is always controversial. To elucidate this intrinsic link, we prepared simple models using glass beads and angular grains, changed wettability by aging, and imaged the three-phase displacement process at high resolution. The results showed that the oil flow occurred through the ways of direct drainage and double imbibition, which is caused by the trapped CO2 under immiscible conditions. More residual CO2 was trapped in the angular grain sample and the water-wet sample, and more residual oil was trapped in the angular grain sample and the oil-wet sample. Under water-wet conditions, CO2 was easier to be trapped as the state of gas-in-oil-in-water or gas-in-water. While under oil-wet conditions, more CO2 was directly surrounded by oil and more small-size residual oil dispersed near the throats. The statistics of the residual clusters showed that the capillary-trapping capacity Ctrap of the angular grain sample was high (12.97% &gt; 8.69%), but the oil recovery R2 was low (89.89% &lt; 93.85%). The altered wettability (water-wet to oil-wet) increased the number of isolated CO2 clusters and the proportion of oil and CO2 in the smaller pores while decreasing the Ctrap (8.93% &lt; 10.34%) and R2 (84.48% &lt; 91.04%). The dissolution trapping and capillary trapping were maximized in the angular grain sample due to the increased surface-to-volume ratio of CO2 clusters and higher capillary force. The effect of wettability on dissolution trapping was slight, but the residual CO2 saturation was higher under water-wet conditions, thus the water-wet media were more conducive to CO2 trapping. We suggested that reservoirs with strong heterogeneity should be selected as CO2 storage sites, and the wettability of oil-wet rocks should be changed by using tertiary oil recovery technology to enhance CO2 storage efficiency and oil recovery. Our study provided direct evidence of the influence of pore geometry and wettability on residual CO2 and oil distribution, and clarified that complex pore geometry and water-wet systems were more conducive to CO2 trapping under immiscible conditions.
Atomic-Scale Observation of Room and Low-Temperature Ultrasonic Properties of Tellurite Glasses
Authors: El-Mallawany Raouf , El-Moniem Amin Abd , Gafaar M S. 
Published: November 2022

Abstract
Theoretical analysis of room temperature bulk modulus and low-temperature ultrasonic attenuation coefficient in the glass system (1-x)TeO2-xV2O5, x = 20, 25, 30, 35, 40 mol % was achieved. The bond compression (BC) and Makishima-Mackenzie (MM) models were used to interpret room-temperature bulk modulus K. The main parameters used were: average cross-link density, number of network bonds per unit volume, and average atomic ring size (). Analyses of low-temperature (300 − 150 K) ultrasonic attenuation (α) at 2, 4, 5, and 6 MHz were achieved by calculating: potential energy, centers of energy loss, elongation, and contraction of the two-well potential. Also, the deformation potential is found to be sensitive to the variations of the modifier content. The analysis revealed a sensitive effect of variation of modifier contents for elongation or contraction of the dual-well potential. The number of centers of energy loss is related to the elastic moduli as a function of the modifier content. Correlation between room temperature bulk modulus and ultrasonic attenuation coefficient has been achieved.
Arteannuin-B and (3-chlorophenyl)-2-spiroisoxazoline derivative exhibit anti-inflammatory effect in LPS-activated RAW 264.7 macrophages and Balb/c mice induced pro-inflammatory responses via down-regulation of NF-κB/P38 MAPK Signalling.
Authors: Sawhney Gifty , Ahmed Zabeer 
Published: November 2022

Abstract
Host inflammatory responses are key to protection against injury; however, persistent inflammation is detrimental and contributes to morbidity and mortality. Herein, we demonstrate the anti-inflammatory role of Arteannuin-B(1) and its novel spirocyclic-2-isoxazoline derivative JR-9 and their side effects in acute inflammatory condition in-vivousing carrageenan-induced paw edema, acetic acid-induced writhing and tail immersion. The results show that spirocyclic-2-isoxazoline derivative has potent anti-inflammatory effect as compared to Arteannuin-B with minimal cell toxicity. In addition, the efficacies of these compounds were also validated by computational and histopathological analysis. Our results show that anti-inflammatory response of JR-9significantly reduce the ability of mouse macrophages to produce NO, TNF-α, and IL-6 following LPS-stimulation.
Short-Term Effects of Square Stepping Exercise on Cognitive and Social Functions in Sedentary Older Adults: A Home-Based Online Trial
Authors: Kawabata Masato , Gan Su Ren , Low Kimmy , Okura Tomohiro 
Published: November 2022

Abstract
Background
The Square Stepping Exercise (SSE) is an exercise training program integrating physical exercise and cognitive components. The potential of SSE in deferring cognitive decline in older adults is encouraging. However, the coronavirus pandemic has made it harder for older adults worldwide to exercise together in person. Therefore, the present study aimed to investigate the short-term effects of a home-based online SSE trial on cognitive and social functions in sedentary older adults.
Methods
A sample of 24 older adults (2 men, 22 women) took part in the current study. Seven participants (2 men, 5 women) completed home-based online SSE sessions under tighter safety regulations, whereas other 17 women attended SSE sessions in person when group exercise with more than 5 people were permitted. To investigate the effects of the online SSE on cognitive and social functions compared to the in-person SSE, 2 times (pre vs. post) × 2 groups (online vs. in-person) mixed ANOVAs were conducted with classic and robust statistical methods on the scores of the Trail Making Test (TMT), the subscale scores of the Physical Activity Group Environment Questionnaire, and the score of the Subjective Vitality Scale.
Results
The interaction between time and groups was significant on the TMT-B to TMT-A (B/A) ratio score (p = .049) and the subscale scores of Individuals Attractions to the Group‒Task (p = .034) and ‒Social (p = .037). The B/A ratio score is an indicator of executive control function. The online SSE group’s ratio score slightly decreased over the sessions, whereas the ratio score significantly increased in the in-person group. As for group cohesion, participants’ involvements with the group task and social interaction with their group were enhanced in the online SSE group over the sessions, compared to the in-person SSE group.
Conclusions
In this study, SSE was carried out online for a short-term and found to be successful to enhance executive function and group cohesion in sedentary older adults. Considering the coronavirus pandemic circumstances, it is valuable to examine the long-term effects of the online SSE in older adults in future research.
Dichotomous Intrinsic Properties of Adult Accumbens Medium Spiny Neurons Vanish in the Fragile X Mouse Model of Autism
Authors: Giua Gabriele , Lassalle Olivier , Makrini-Maleville Leila , Valjent Emmanuel , Chavis Pascale , Manzoni Olivier Jacques José 
Published: November 2022

Abstract
Background
Fragile X syndrome (FXS), the most common monogenic cause of autism and inherited intellectual disability, is caused by the mutation of a single gene, Fmr1, which encodes the Fragile X mental retardation protein (FMRP). FXS patients suffer from cognitive, emotional, and social deficits indicative of dysfunction in the nucleus accumbens (NAc), a structure central to the control of social behavior. The major cell type of the NAc, medium spiny neurons (MSNs), are differentiated in two subtypes based on their expression of either dopamine D1 or D2 receptors, their connectivity, and associated behavioral functions. Understanding how the absence of FMRP differentially affects the cellular properties of MSNs is a necessary step to categorize FXS cellular endophenotypes.
Methods
To address this question, we comprehensively compared the intrinsic passive and active properties of MSN subtypes identified in a novel Fmr1-/y :: Drd1a-tdTomato mouse model allowing in-situ identification of MSN subtypes in FXS mice.
Results
Although Fmr1 transcripts and their gene product, FMRP, were found in both MSNs subtypes, the results suggest cell-autonomous functions for Fmr1. The opposite membrane properties and action potential kinetics that normally discriminate D1- from D2-MSNs in WT mouse is either reversed or abolished in Fmr1-/y :: Drd1a-tdTomato mice. Multivariate analysis shed light on the compound effects of Fmr1 ablation by revealing how the phenotypic traits that distinguish each cell type in WT are modified in FXS.
Conclusions
Together these data show that in Fragile X mice the normal dichotomy that characterizes NAc D1- and D2-MSNs is thrown out of balance, leading to a uniform phenotype that could underlie selected aspects of the pathology.
Associations of LH and FSH with reproductive hormones depending on each stage of the menopausal transition
Authors: Kawakita Takako , Yasui Toshiyuki , Yoshida Kanako , Matsui Sumika , Iwasa Takeshi 
Published: November 2022

Abstract
Introduction: Associations of luteinizing hormone (LH) with androgens during the menopausal transition and associations between follicle-stimulating hormone (FSH) levels and various diseases related to reproductive hormones in postmenopause have received much attention. LH and FSH are also known to be associated with activities of enzymes related to reproductive hormones. We examined the associations of LH and FSH with androgens and estrogens in each stage according to a classification from menopausal transition to postmenopause.
Methods: We divided the 173 subjects into 6 groups according to menstrual regularity and follicle-stimulating hormone level: mid reproductive stage (Group A), late reproductive stage (Group B), early menopausal transition (Group C), late menopausal transition (Group D), very early postmenopause (Group E) and early postmenopause (Group F). Levels of LH, FSH, dehydroepiandrosterone sulfate (DHEAS), estradiol, estrone, testosterone (T), free T, androstenedione and androstenediol were measured.
Results: In Group A, LH showed significant positive correlations with androstenedione and estrone. In Group D, LH was positively associated with T and free T and was negatively associated with estradiol. In Groups B, C, D and F, LH showed significant positive correlations with FSH, and there was a tendency for an association between LH and FSH in Group E. FSH was associated with estradiol but not with estrone in Groups C and D.
Conclusion: The associations of LH and FSH with reproductive hormones were different according to the stage of the menopausal transition. The associations between gonadotrophine levels and androgen levels may be important for metabolism from menopausal transition to postmenopause.
­­Simulations of genomic selection accuracy and model updating across multiple breeding strategy scenarios in common bean
Authors: Chiaravalotti Isabella , Lin Jennifer , Arief Vivi , Jahufer Zulfi , Osorno Juan , McClean Phillip , Jarquin Diego , Hoyos-Villegas Valerio 
Published: November 2022

Abstract
Genomic selection predicts the breeding value of selection candidates according to genotypes that are estimated to have favorable effects based on a model. The effectiveness of genomic selection is strongly tied to its prediction accuracy. Previous studies have evaluated the accuracy of genomic selection using simulations. The aim of this study was to evaluate changes in accuracy of genomic selection based on many known QTLs identified in the literature and determine their relationship with true breeding values. Simulation results revealed that correlation-based prediction accuracies (also referred to as realized accuracy) fluctuate depending on trait genetic architecture, breeding strategy and the number of initial parents involved in the breeding program. Generally, maximum accuracies were achieved under a mass selection strategy followed by pedigree and single seed descent methods. Model updating benefitted some breeding strategies more than others (e.g., single seed descent vs mass selection). For low heritability traits (i.e., yield), conventional methods provided comparable rates of genetic gain, but genetic gain under genomic selection reached a plateau in a lower number of cycles.