bluuebunny/crossref_metadata_2025_split huggingface dataset:
CT-707 Overcomes Hypoxia-mediated Sorafenib Resistance in Hepatocellular Carcinoma by Inhibiting YAP Signaling
Authors: Chen Zibo , Yuan Tao , Yan Fangjie , Ye Song , Xie Qin , Zhang Bo , Lin Nengmin , He Qiaojun , Yang Bo , Zhu Hong 
Published: February 2022

Abstract
Background: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Sorafenib is the first-line treatment for advanced HCC, but the anti-cancer effects remain to be improved as indicated by its low response rates and failure to prolong the progression-free survival (PFS). Thus, it is urgent to explore approaches to improve the clinical outcome. Materials and methods: The effect of Sorafenib in HCC was analyzed by SRB (sulforhodamine B) assay in normoxia and hypoxia, respectively. The different dose combination effect of CT707 and sorafenib was analyzed by SRB assay in hypoxia. Flow cytometry assay was used to detect the cell apoptosis rate with CT707 and sorafenib treatment in hypoxia. Western blotting was used to detect the expression levels of apoptosis -related proteins and the mechanism of CT707 overcome the resistance of sorafenib in hypoxia. Results: Our study showed that the characteristic intratumor hypoxia of advanced HCC is one of the major factors which mediated the drug resistance towards sorafenib in HCC. And CT-707, a novel multi-kinase inhibitor, could sensitize the hypoxic HCC cells towards sorafenib. Further studies showed that CT-707 abolished the nuclear translocation of Yes Associate-Protein (YAP), which has been demonstrated as one of mechanism of hypoxia-mediated sorafenib-resistance in HCC. Conclusions: Overall, this study not only favors the development of this novel multi-kinase inhibitor CT-707 as a therapeutic agent against HCC, but also provides a potential strategy to overcome the hypoxia-mediated resistance to sorafenib in HCC patients.
Effect of Previous Chlamydia Trachomatis Infection on the Outcomes of IVF/ICSI Treatment: A retrospective study
Authors: Zhang Dan , Wang Zengyan , Hu Xingyuan , Ma Chunguang , Ma Yuanlin , Xu Yanwen 
Published: February 2022

Abstract
Background: The impact of Chlamydia trachomatis infection (CT) on the outcomes of In-Vitro Fertilizition / Intracytoplasmic sperm injection (IVF/ICSI) has been controversial. Methods: This retrospective study investigated the effect of cured CT infection and the intervals between infection and the first embryo transfer on pregnancy outcomes in infertile patients undergoing IVF/ICSI. A total of 431 infertility women aged 20-38 years with or without Chlamydia trachomatis infection before fresh/ frozen embryo transfer were included. We subdivided the infected group into two subgroups for ≤ 3 months and > 3 months according to the different intervals between Chlamydia trachomatis positive testing and embryo transfer. The effect of chlamydia infection and the intervals between infection and embryo transfer on pregnancy outcomes was analyzed. Results: Our results revealed that implantation rate was significantly lower and the premature rupture of membranes (PROM) was higher in women with CT infection than non-infection. The multivariate logistic regression analysis adjusting for baseline characteristics showed no significant difference in embryo implantation between neither two groups nor two subgroups while patients in infection group have higher rate of PROM than those in control group.Conclusions: The study suggests that previous Chlamydia trachomatis infection would not impair embryo implantation but lead to high risk of PROM and the intervals between infection and embryo transfer would not impact the pregnancy outcomes of IVF/ICSI.
Metal paddlewheels as sensors for detection of SO2 gas: A DFT study
Authors: Sirijaraensre Jakkapan 
Published: February 2022

Abstract
The sensing properties of the paddlewheel-type metal dimer (M-BTC: M = Fe, Ni, Cu, Zn, and Pd) toward SO2 gas were theoretically investigated using density functional theory (DFT) at the M06-L level of theory. Single point calculations were carried at the M06 functional to correct the energetic properties and HOMO-LUMO energy gap. The O-bound adsorption complex of SO2 on the metal center of paddlewheels is found to be thermodynamically favorable than the S-bound ones. The trend of adsorption energy of SO2 on the metal center is in the order Pd-BTC < Cu-BTC < Ni-BTC < Zn-BTC < Fe-BTC. Among these five paddlewheels, the Ni-BTC and Zn-BTC paddlewheels are highly sensitive towards SO2 gas as compared to the other systems. The density of states reveals that the adsorption process significantly reduces the LUMO of the system to lower energies, enhancing the conductivity of the system. From DFT results, the energy gap of Ni-BTC and Zn-BTC is significantly reduced by 18.0% and 41.0% after the adsorption of SO2 on the metal center. These results suggest the great potential of Ni-, and Zn-BTC paddlewheels as SO2 sensors.
Validating the Edinburgh Postnatal Depression Scale (EPDS) for use in less at risk Ugandan postpartum women
Authors: Atuhaire Catherine , Brennaman Laura , Nambozi Grace , Ngonzi Joseph , Atwine Daniel , Rukundo Godfrey Zari 
Published: February 2022

Abstract
BackgroundAlthough the Edinburgh Postnatal Depression Scale (EPDS) has been recognized as a reliable screening scale for postpartum depression among mothers worldwide, no study has validated this scale in Uganda. The objective of this study was to establish the accuracy of the EPDS as a screening scale for postpartum depression (PPD) for use in less at risk Ugandan postpartum women in comparison with the Mini-International Neuropsychiatric Interview (MINI 7.0.2) for the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5).Methods We conducted a descriptive, cross-sectional study at one regional referral hospital and two peri-urban primary care postpartum clinics that serve a rural community in the southwestern region of Uganda. The study targeted 287 mothers aged 18 to 49 years during their six weeks’ postpartum visit. During data collection, mothers were first screened using the EPDS in one of the private rooms and then clinically diagnosed in another private room using the MINI 7.0.2. With the EPDS, PPD was diagnosed if the mother had a cutoff point of ≥ 10. Runyankore-Rukiga was the language used in the Ugandan version of the EPDS and this data was obtained from 11th November 2019 to 10th June 2020. The accuracy of the EPDS was determined using the MINI 7.0.2 as a reference standard.ResultsA total of 287 mothers aged 18 to 49 years during their six weeks’ postpartum visit were included in the study. Overall PPD prevalence was 29.5% versus 26.5% with EPDS and the MINI 7.0.2 for the DSM-5 diagnostic criteria for depression respectively, p = 0.239. The sensitivity, specificity, positive predictive value and negative predictive value of the EPDS established by this study were 86.8%, 92.1%, 80.5% and 94.9% respectively. The cut-off point ≥10 was the most acceptable point in detecting mothers suffering from PPD. The area under the ROC curve that shows the overall performance of the scale against the MINI 7.0.2 was 0.89 for Bwizibwera HCIV, 0.97 for Kinoni HCIV and 0.84 for MRRH.ConclusionEPDS can successfully screen for postpartum depression in southwestern Uganda at a cutoff score of ≥10. It has a good diagnostic performance to correctly detect PPD among postpartum mothers.
Apolipoprotein E4 polymorphism is associated with a higher risk of aspiration pneumonia in young stroke patients
Authors: Park Hae-Yeon , Oh Hyun-Mi , Kim Tae-Woo , Kim Youngkook , Park Geun-Young , Hwang Hyemi , Im Sun 
Published: February 2022

Abstract
Background Genetic polymorphisms may be associated with infections, and some genes are known to be associated with pneumonia. Aspiration pneumonia is one of the major complications after stroke, and this study aimed to evaluate genetic effects on post-stroke aspiration pneumonia. Methods Blood samples were obtained from a total of 206 post-stroke participants (males, n = 136; mean age, 63.8 years). Genotyping was done for catechol-O-methyltransferase (rs4680 and rs165599), dopamine receptors (DRD1; rs4532, DRD2; rs1800497, DRD3, rs6280), brain-derived neurotrophic factor (rs6265), apolipoprotein E (rs429358, rs7412), and the interleukin-1 receptor antagonist gene (rs4251961). The subjects were stratified into two groups, aged < 65 (young) and ≥ 65 (elderly) years. Functional parameters and swallowing outcomes were measured at enrollment and 3-months post-onset. The primary outcome was the incidence of aspiration pneumonia. Results Analysis of the association between genetic polymorphisms and aspiration pneumonia history showed that a minor C rs429358 allele was associated with the occurrence of aspiration pneumonia in the young group, both in the additive and dominant models (odds ratio [OR], 4.53; 95% Confidence Interval [CI]: 1.60 – 12.84, P = 0.004). In the multivariable logistic analysis, a minor C rs429358 allele increased the risk of post-stroke aspiration pneumonia by 5.35 (95% CI: 1.64 – 20.88). In contrast, no genetic effects were seen in the elderly group. Conclusions A minor C rs429358 allele in young age stroke patients may increase the incidence of post-stroke aspiration pneumonia. Genetic polymorphism may provide useful information on how certain individuals are at increased risk of post-stroke aspiration pneumonia. Clinical Trial Registration-URL: https://www.clinicaltrials.gov. Unique identifier: NCT0357744
Characteristics of the Gut Microbiota in Pregnant Women With Fetal Growth Restriction
Authors: Tu Xinzhi , Duan Chun , Lin Bingying , Li Kangfeng , Gao Jie , Yan Huaying , Wang Kejian , Zhao Zhao 
Published: February 2022

Abstract
Background: Fetal growth restriction (FGR) in utero leads to failure of fetus to reach the genetically normal growth potential. Currently available means of treating FGR are limited. And it remains unknown how pregnant women who give birth to FGR fetus differ in gut microbiota composition from normal pregnant women.Methods: In this case-control study, fecal samples were obtained from maternal rectum in the operation room by obstetricians under strict aseptic conditions. We compared gut microbiota of 14 pregnant women with FGR and 18 normal controls by performing 16S rDNA amplicon sequencing.Results: We identified significant differences in β-diversity between the FGR and control groups (P < 0.05). At genus level, Bacteroides, Faecalibacterium and Lachnospira were highly abundant in the FGR subjects, which are significantly enriched in KEGG pathways related to glycometabolism. Conclusion: These findings demonstrated that the distinct composition of the gut microbiota between FGR and normal pregnant women could contribute to an improved understanding of the prevention and treatment of FGR.
Fuzzy logic-based integrated performance evaluation of a water distribution network
Authors: Beker Bahar Adem , Kansal Mitthan Lal 
Published: February 2022

Abstract
A water distribution network (WDN) is an essential component of an urban water supply scheme to deliver safe and adequate water to consumers under various operational conditions. This study focuses on the performance evaluation of an urban WDN using fuzzy logic-based aggregation of reliability, resilience, and vulnerability indices. To assess the individual performance indicators, this study advocates the pressure-dependent analysis (PDA) for hydraulic simulation. Furthermore, it advocates a fuzzy rule-based aggregated performance index (API) that will deliver the outcome in linguistic form and help the decision-maker to prioritize the maintenance of the WDN. The proposed method is illustrated with the help of a real-time WDN for part of Dire Dawa city in Ethiopia. It has been found that the API values for this network are 0.721 and 0.624, respectively, under normal and abnormal conditions, which are just satisfactory. It has been noticed that nodes J4, J44, J47, and J49 are critical from the overall low API. Efforts should be made to improve the hydraulic and residual chlorine conditions at these nodes to increase the API. It is felt that such a methodology will help the decision-makers to improve the performance of an existing urban WDN.
Impacts of climate change on drinking water quality in Norway
Authors: Skaland R. G. , Herrador B. G. , Hisdal H. , Hygen H. O. , Hyllestad S. , Lund V. , White R. , Wong W. K. , Nygård K. 
Published: February 2022

Abstract
Climate change will lead to higher temperatures, increased precipitation and runoff, as well as more intense and frequent extreme weather events in Norway. More extreme rainfall and increased runoff are historically associated with higher concentrations of indicator bacteria, colour and turbidity in raw water of Norwegian waterworks. Regional information about the risk for drinking water deterioration by the end of the century is essential for evaluating potential treatment capacity upgrades at the waterworks. We combined locally downscaled future climate scenarios with historical associations between weather/runoff and water quality from a wide spread of waterworks in Norway. With continued climate change, we estimate higher concentrations of water quality indicators of raw water by the end of the century. The water quality is estimated to deteriorate mainly due to the projected increase in rainfall, and mainly in the Western and Northern parts of Norway. While large waterworks seem to be able to adapt to future conditions, the degradation of raw water quality may cause future challenges for the treatment processes at smaller waterworks. Combining these results with further studies of treatment effects and microbial risk assessments is needed to ensure sufficient treatment capacities of the raw water in the future.
Microbial pollution in inland recreational freshwaters of Quetta, Pakistan: an initial report
Authors: Luqman Muhammad , Awan Muhammad Umer Farooq , Muhammad Sohaib , Daud Shakeela , Yousafzai Asma , Arooj Fariha 
Published: February 2022

Abstract
Parasitic contamination of surface waters, especially recreational waters, is a serious problem for under-developed nations like Pakistan, where numerous outbreaks of parasitic diseases are reported each year. In the current study, parasitic presence in two surface waters (Hanna Lake and Wali-Tangi Dam) of Quetta was monitored quarterly for 1 year. The methodology involved the pre-concentration of the water samples and the subsequent preparation for the microscopic search of parasites. Physico-chemical and bacteriological variables were also studied. Wet staining, modified Trichrome staining, and modified acid-fast staining methods were used to identify various parasitic forms (cysts, oocysts, eggs, trophozoites). Collectively 11 parasitic elements (10 in Lake and 8 in Dam) belonging to 10 species were recorded, many of which are potential human pathogens. The species identified include Trichomonas sp., Isospora sp., Balantidium coli, Cryptosporidium sp., Entamoeba spp., amoebas, Microsporidium sp., Endolimax nana, Ascaris lumbricoides, and Giardia spp. Parasitic contamination remained persistent in both locations throughout the year independent of physico-chemical parameters (temperature, EC, pH, turbidity, and DO) and bacterial concentration of water. Reliance on bacterial presence for monitoring of recreational waters can be a risk for tourists. Entamoeba spp. and A. lumbricoides may be used for surface water monitoring in these waters.
Heterogeneous activation of H2O2/Na2S2O8 with iron ore from water distribution networks for pollutant removal
Authors: Zhong Dan , He Fu , Ma Wencheng , Wu Yichuan , Dong Jiaju 
Published: February 2022

Abstract
In this study, we investigated using the main composition of pipe deposits from water distribution networks as catalyst to activate dual-oxidant H2O2/Na2S2O8 system to produce radicals for perchloroethylene and chloramphenicol removal. According to the results, the degradation efficiency of perchloroethylene by H2O2/Na2S2O8 system was 92.05% within 8 h. Due to the slow conversion between ≡Fe3+ and ≡Fe2+, the hydroxylamine was introduced to reduce reaction time. As for the results, the degradation efficiency of chloramphenicol in the H2O2/Na2S2O8 system with hydroxylamine assistance was 73.31% within 100 min. Meanwhile, several key affecting factors and the kinetic models were investigated. The primary radicals were identified by electron paramagnetic resonance and radical scavenging tests. Eleven degradation products were confirmed by high-resolution liquid chromatography-mass spectrometry. The result of this study provided the theoretical basis for resource utilization of pipe deposits in water treatment in case of emerging contamination events.
Kinetic models evaluation for chemical organic matter removal prediction in a full-scale primary facultative pond treating municipal wastewater
Authors: Alavi Javad , Ansari Sepideh 
Published: February 2022

Abstract
This study focuses on determining the bio-kinetic coefficients of chemical oxygen demand (COD) removal in full-scale primary facultative ponds (PFPs) system on the basis of 3-year continuous operation. The mean removal of chemical oxygen demand (COD), total suspended solid (TSS) and volatile suspended solid (VSS) were 80, 59 and 49%, respectively. The first-order model paired with continuous stirred-tank reactor (CSTR) and plug flow (PF) regimes, PF k–C*, Stover-Kincannon and Grau second-order models were applied to link COD concentrations at the inlet and outlet of the system and to compare the predictive power of models for the estimation of effluent COD concentrations. The Stover-Kincannon model showed the best adaptability (r2 = 0.9294) with the maximum substrate utilization rate (Umax) of 79.14 g/L· d and saturation constant (KB) of 80.65 g/L· d, whereas the Grau second-order model was the best model to predict outlet COD concentrations (r2 = 0.6925). The computed constants, m and n, of the Grau second-order model were 0.6725 and 15.867 d−1, respectively. While the Stover-Kincannon kinetic rates obtained in this study can be used to design the PFP systems in similar operational conditions, the appropriate prediction of pond behavior can be achieved using the Grau model.
Influence of plants on the salinity of constructed wetlands effluents
Authors: Teixeira Denis Leocádio 
Published: February 2022

Abstract
Reuse of constructed wetlands effluents for fertigation is a promising practice in regions that suffer from water scarcity. Thus this study aimed to evaluate the influence of Vetiver (Chrysopogon zizanioides) and Tifton 85 (Cynodon sp.) grasses cultivation on salinity of the saturated solution of the Horizontal Subsurface Flow Constructed Wetlands (HSSF-CW) porous medium. The grasses were cultivated in HSSF-CW mesocosm and submitted to different levels of salinity for six months. The crop's evapotranspiration, biomass productivity, the electrical conductivity variation (ΔEC) in the solution under treatment and the water use efficiency (WUE) of these grasses were evaluated. The cultivation of Vetiver and Tifton 85 in HSSF-CW provided an increase in the electrical conductivity of the solution mainly for the lowest levels of affluent salinity. The ΔEC in HSSF-CW grown with Vetiver and Tifton 85 grasses were 90.20 and 27.13 mS cm−1, respectively. Meteorological variables maximize the effect of the vegetative development in ΔEC of the solution. The WUE values of Vetiver and Tifton 85 grasses were 1.77 and 4.18 g kg−1, respectively. Thus plants with high water use efficiency such as Tifton 85 is indicated for HSSF-CW in which the effluents are used in the fertigation of agricultural crops.
ND-16: A Novel Compound for Inhibiting the Growth of Cutaneous T Cell
Lymphoma by Targeting JAK2
Authors: Zhu Man , Liu Yanhong , Lei Panpan , Shi Xianpeng , Tang Wenjuan , Huang Xiaoyue , Pan Xiaoyan , Wang Cheng , Ma Weina 
Published: February 2022

Objective:
Cutaneous T cell lymphoma (CTCL) is a kind of extranodal non-Hodgkin Tcell
lymphoma without healable treatment in the clinic. JAK2 amplification in CTCL patients
makes it a potential target for CTCL treatment. In the present study, we aimed to evaluate the anticancer
effect of ND-16, a novel nilotinib derivate, on CTCL cells and the underlying mechanism
targeting JAK2.

Methods and Results:
We found that ND-16 was capable of regulating JAK2 and had a selective
inhibitory effect on CTCL H9 cells. The surface plasmon resonance and molecular docking study
indicated ND-16 bound to JAK2 with a high binding affinity. Further investigation revealed that
ND-16 inhibited the downstream cascades of JAK2, including STATs, PI3K/AKT/mTOR, and
MAPK pathways, followed by regulation of Bcl-2 family members and cell cycle proteins CDK/-
Cyclins. Flow cytometry analysis confirmed these results that ND-16-treated H9 cells showed cell
apoptosis and cell cycle arrest at S-phase.

Conclusion:
ND-16 may be of value in a potential therapy for the management of CTCL.
Monotherapy for the Treatment of Lymphedema in Children: A Review
Authors: de Godoy Jose Maria Pereira , de Godoy Ana Carolina Pereira , Guerreiro Godoy Maria de Fatima 
Published: February 2022

Abstract:
The Godoy Method of cervical lymphatic therapy is the first treatment option as monother-apy for children which facilitates achieving normalization or near normalization of the affected limb as well as the maintenance of the results, which could assist millions of children throughout the world.
Performance of Screen in a Sudden Expanding Stilling Basin under the Effect of the Submerged Hydraulic Jump
Authors: Elaswad Suzan , Saleh Osama Khairy , Elnikhili Eman 
Published: February 2022

Background:
Hydraulic jump is considered the most appropriate option for designers to dissipate energy through stilling basins.

Methods:
Tests on a screen that produced a submerged hydraulic jump were conducted to dissipate the energy of water passing beneath a vertical gate. Various positions of a screen in a sudden expanding stilling basin were investigated. In comparison to the no-screen case, the effect of a screen downstream of the gate on the water surface profile was also investigated.

Results:
The best screen position was 0.25 of the abutment lengths with a 0.285 relative screen area, which resulted in the most energy loss with the lowest tail water depth and submerged hydraulic jump length. Theoretical equations based on the energy and momentum principles were derived.

Conclusion:
An acceptable agreement was obtained between the derived theoretical relative depth of the hydraulic jump and the measured values.