bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prenatal THC Exposure Induces Sex-Dependent Neuropsychiatric Endophenotypes in Offspring and Long-Term Disruptions in Fatty-Acid Signaling Pathways Directly in the Mesolimbic Circuitry
Authors: Sarikahya Mohammed H. , Cousineau Samantha , De Felice Marta , Lee Kendrick , Wong Karen KW , DeVuono Marieka V. , Jung Tony , Rodríguez-Ruiz Mar , Ng Tsun Hay Jason , Gummerson Dana , Proud Emma , Hardy Daniel B. , Yeung Ken K.-C. , Rushlow Walter , Laviolette Steven R. 
Published: September 2022

AbstractDespite increased prevalence of maternal cannabis use, little is understood regarding potential long-term effects of prenatal cannabis exposure (PCE) on neurodevelopmental outcomes. While neurodevelopmental cannabis exposure increases the risk of developing affective/mood disorders in adulthood, the precise neuropathophysiological mechanisms in male and female offspring are largely unknown. Given the interconnectivity of the endocannabinoid (ECb) system and the brain’s fatty acid pathways, we hypothesized that prenatal exposure to Δ9-tetrahydrocannabinol (THC) may dysregulate fetal neurodevelopment through alterations of fatty-acid dependent synaptic and neuronal function in the mesolimbic system. To investigate this, pregnant Wistar rats were exposed to vehicle or THC (3 mg/kg) from gestational day (GD)7 until GD22. Anxiety-like, depressive-like, and reward-seeking behavior, electrophysiology, and molecular assays were performed on adult male/female offspring. Imaging of fatty acids using matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) was performed at prepubescence and adulthood. We report that PCE induces behavioral, neuronal, and molecular alterations in the mesolimbic system in male and female offspring, resembling neuropsychiatric endophenotypes. Additionally, PCE resulted in profound dysregulation of critical fatty acid pathways in the developing brain lipidome. Female progeny exhibited significant alterations to fatty acid levels at prepubescence but recovered from these deficits by early adulthood. In contrast, males exhibited persistent fatty acid deficits into adulthood. Moreover, both sexes maintained enduring abnormalities in glutamatergic/GABAergic function in the nucleus accumbens (NAc). These findings identify several novel long-term risks of maternal cannabis use and demonstrate for the first time, sex-related effects of maternal cannabinoid exposure directly in the developing neural lipidome.
Predictable Fluctuations in Excitatory Synaptic Strength Due to Natural Variation in Presynaptic Firing Rate
Authors: Ren Naixin , Wei Ganchao , Ghanbari Abed , Stevenson Ian H. 
Published: September 2022

Many controlledin vitrostudies have demonstrated how postsynaptic responses to presynaptic spikes are not constant but depend on short-term synaptic plasticity (STP) and the detailed timing of presynaptic spikes. However, the effects of short-term plasticity (depression and facilitation) are not limited to short, subsecond timescales. The effects of STP appear on long timescales as changes in presynaptic firing rates lead to changes in steady-state synaptic transmission. Here, we examine the relationship between natural variations in the presynaptic firing rates and spike transmissionin vivo. Using large-scale spike recordings in awake male and female mice from the Allen Institute Neuropixels dataset, we first detect putative excitatory synaptic connections based on cross-correlations between the spike trains of millions of pairs of neurons. For the subset of pairs where a transient, excitatory effect was detected, we use a model-based approach to track fluctuations in synaptic efficacy and find that efficacy varies substantially on slow (∼1 min) timescales over the course of these recordings. For many connections, the efficacy fluctuations are correlated with fluctuations in the presynaptic firing rate. To understand the potential mechanisms underlying this relationship, we then model the detailed probability of postsynaptic spiking on a millisecond timescale, including both slow changes in postsynaptic excitability and monosynaptic inputs with short-term plasticity. The detailed model reproduces the slow efficacy fluctuations observed with many putative excitatory connections, suggesting that these fluctuations can be both directly predicted based on the time-varying presynaptic firing rate and, at least partly, explained by the cumulative effects of STP.SIGNIFICANCE STATEMENTThe firing rates of individual neurons naturally vary because of stimuli, movement, and brain state. Models of synaptic transmission predict that these variations in firing rates should be accompanied by slow fluctuations in synaptic strength because of short-term depression and facilitation. Here, we characterize the magnitude and predictability of fluctuations in synaptic strengthin vivousing large-scale spike recordings. For putative excitatory connections from a wide range of brain areas, we find that typical synaptic efficacy varies as much as ∼70%, and in many cases the fluctuations are well described by models of short-term synaptic plasticity. These results highlight the dynamic nature ofin vivosynaptic transmission and the interplay between synaptic strength and firing rates in awake animals.
Criminal Offense or Civil Law Dispute: to the Issue of Assessing Unfair Information Business under the Criminal Legislation of Ukraine
Authors: Yevtieieva Daryna 
Published: September 2022

The article provides a criminal assessment of unfair information business (“information fraud”). Based on the analysis of the Supreme Court’s positions and through the prism of such manifestations as nonfulfillment of obligations and improper fulfillment of obligations (untimely, incomplete and poor-quality fulfillment of obligations in the form of service), it is determined whether this phenomenon falls under criminal fraud within the legislation of Ukraine.
Ioannikii Malynovskyi as an Enlightener of the History of Law
Authors: Matviichuk Mariia , Popeliushko Vasil , Herasymchuk Oleh , Gongalo Serhii , Borzhetska Nataliia 
Published: September 2022

Aim. The purpose of the study is to research the career of Professor Ioannikii Malynovskyi in higher education, his contribution to its development, the goals of the university education.
Methods. In the study several different methods were used in the system and interaction. A dialectical method, which boils down to the fact that all phenomena in society have a beginning and an end. The historical method was used to take into account historical traditions, socio-cultural roots of the state and law. A logical-semantic method was also used to help define the conceptual apparatus used in the study. Formal-legal method was used to analyse and disclose legal concepts.
Results. The research showed that Malynovskyi conducted scientific researches in the chosen field and by getting acquainted with the heritage of national and world culture. The professor made considerable efforts in education to democratise higher education, in particular, by admitting women to higher education in Western Siberia. He defined the goals of university teaching: 1) to learn to acquire knowledge, the method of scientific research and, 2) to get acquainted with the current state of science. The scientist was the first to create a chronologically consistent, comprehensive subject course on the history of Rus’ law.
Conclusions. Malynovskyi’s contribution to the democratisation of higher education already belongs to history, but his scientifically based recommendations on the goals of university education and means of achieving it are not without relevance today, but especially on the practical side in training future legal practitioners which are topical for today.
Analysis of the restoration of cardiology diagnostics scope in the Russian Federation during the COVID-19 pandemic: results of the Russian segment of the INCAPS COVID 2 study under the auspices of the International Atomic Energy Agency
Authors: Ansheles A. A. , Sergienko V. B. , Sinitsyn E. V. , Vakhromeeva M. N. , Kokov A. N. , Zavadovsky K. V. , Ryzhkova D. V. , Karalkin A. V. , Shurupova I. V. , Pospelov V. A. , Migunova E. V. , Sayfullina G. B. , Dariy O. Yu. , Zhuravlev K. N. , Itskovich I. E. , Gagarina N. V. , Hirschfeld C. , Williams M. C. , Shaw L. J. , Malkovskiy E. , Better N. , Cerci R. , Dorbala Sh. , Karthikeyan G. , Pascual T. N. , Villines T. , Vitola J. V. , Cohen Y. , Randazzo M. , Sewanan L. , Pynda Y. , Dondi M. , Paez D. , Einstein A. J. 
Published: September 2022

Aim. To assess the changes in cardiology diagnostics scope in the Russian Federation during the coronavirus disease 2019 (COVID-19) pandemic.Material and methods. In an online survey organized by the Division of Human Health of the International Atomic Energy Agency (IAEA), including questions about changes in the workflow of diagnostic laboratories and the scope of cardiac diagnostics from March 2019 (pre-pandemic) to April 2020 (first wave of the pandemic) and April 2021 (recovery stage), 15 Russian medical centers from 5 cities took part.Results. The decrease in the diagnostics scope by April 2020 by 59,3% compared to March 2019, by April 2021, stopped and was replaced by growth (+7,1%, the recovery rate, 112,1%). The greatest increase was in routine examinations, such as echocardiography (+11,6%), stress echocardiography (+18,7%), stress single photon emission computed tomography (+9,7%), and to a lesser extent resting computed tomography angiography (+7,0%) and magnetic resonance imaging (+6,6%). The performance of stress electrocardiography, stress magnetic resonance imaging and positron emission tomography for the diagnosis of endocarditis in April 2021 compared to March 2019 decreased by 10,3%, 63,2% and 62,5%, respectively.Conclusion. Due to the resumption of patient admissions for cardiac examinations during the ongoing COVID-19 pandemic, with the anti-epidemic measures taken and certain changes in the workflow, there has been a recovery in the diagnostics scope in most of the included centers.
Mid-term outcomes of surgical myocardial revascularization using coronary endarterectomy in diffuse coronary artery disease
Authors: Visker Ya. Yu. , Molchanov A. N. 
Published: September 2022

Aim. To evaluate the mid-term outcomes of surgical myocardial revascularization in combination with coronary endarterectomy in patients with diffuse coronary artery disease (CAD).Material and methods. In this cohort, non-randomized, retrospective, longitudinal study, we compared the mid-term outcomes of surgical myocardial revascularization in combination with coronary artery endarterectomy in patients with diffuse CAD with the outcomes of surgical myocardial revascularization without endarterectomy in patients without diffuse CAD. The study group included 93 patients, while the control group — 99 patients. Mid-term mortality, morbidity, and angiographic outcomes of surgical revascularization were assessed.Results. The mean follow-up period was 46,7±18,5 months. Mid-term mortality was 5,5% (n=5) in the coronary endarterectomy group and 3,1% (n=3) in the isolated coronary artery bypass grafting (CABG) group (p=0,486). Angina recurrence was noted in 14,3% (n=13) of patients in the endarterectomy group and in 14,4% (n=14) of cases in the isolated CABG group (p=0,977). Coronary artery stenting was required in the mid-term period in 4,4% (n=4) of patients in the endarterectomy group and 4,1% (n=4) (p=1000) in the isolated CABG group. A stroke in the mid-term period occurred in 1 (1,1%) patient of the study group and 3 (3,1%) patients in the control group (p=0,334). Graft patency in the anterior interventricular artery was 90,9%, while in the circumflex artery — 100% and in the right coronary artery — 80,4%. There were no significant differences in the patency level between the study and control groups. Quality of life did not differ significantly between groups in the mid-term period.Conclusion. Coronary endarterectomy is not associated with an increase in mortality and morbidity in the mid-term period, and is accompanied by satisfactory angiographic patency rates. There was no negative effect of coronary endarterectomy on the quality of life in the mid-term period.
Bridging the Gap: Micro-credentials for Development
Authors: McGreal Rory , Mackintosh Wayne , Cox Glenda , Olcott, Jr. Don 
Published: September 2022

This paper describes current trends and issues in implementing micro-credentials. The Covid19 epidemic, combined with the increasing cost of higher education; employer concerns about graduate skills and competencies; increasing inequities in access; and student frustrations about lack of job opportunities have all been a catalyst for universities, colleges, independent credentialing agencies, and leaders of national qualification frameworks to rethink the broader credentials continuum in terms of open education and micro-credentials. Students desire more options at lower costs to combine their education and training for jobs. Employers want entry-level employees with better skills and capacity to learn. As a result, major colleges and universities are now actively engaged in granting and/or recognising micro-credentials. Standardising qualifications based on time competencies is an essential requirement for credit transfer among institutions. Micro-credentials are important in ensuring the acceptance and stackability of credentials from different institutions, while providing employers with a secure and unalterable permanent digital record of applicants' abilities to perform skills of high value in the workplace. The OERu (Open Educational Resources universitas) provides an example of how one international consortium is supporting SDG4: Education for All by implementing micro-credentials allowing for maximum transferability among institutions in different countries. The lesson for strategic leaders is simplicity. Micro-credentials should be well Integrated into current institutional programs, rendered easy-to-use with clear validation metrics, providing a value-added benefit for all stakeholders. A list of recommendations to institutions, governments, UNESCO and Non-Governmental Organizations (NGOs) is provided.
Nodal Analysis of Oil and Gas Production Systems
Authors: Jansen Jan Dirk 
Published: September 2022

Nodal Analysis of Oil and Gas Production Systems provides a modern view on the use of nodal analysis techniques to optimize the production from oil and gas wells. It covers multiphase flow through flow lines, wells, chokes and the near-well reservoir. It teaches the development of mathematical models for those system elements, and how to implement these in computer code. It explains the underlying physics, starting from first principles whenever possible, and reverting to empirical correlations whenever necessary. It covers the essential concepts in nodal analysis of a well system and aims at providing the readers with enough knowledge to use commercial nodal analysis software for more complex systems, explore the literature in this field, and expand their knowledge.
Supplementary items for this book can be downloaded here. (https://www.tudelft.nl/citg/over-faculteit/afdelingen/geoscience-engineering/sections/reservoir-engineering/staff/academic-staff/prof-dr-ir-jd-jan-dirk-jansen/nodal-analysis)
Synergistic Effect of potassium iodide and sodium (Z)-4-oxo-4-p-tolyl-2-butenoate on the Characterization, Treatment, and Protection of Two Bronze Objects from Thamar Museum, Yemen
Authors: Megahed Mohamed M. , El-Shamy A. M. 
Published: September 2022

Abstract

Objects from the Thamar regional museum in Yemen were used in the investigation. In addition to a thick layer of light-green/brown corrosion result, they also had a rust-colored black and brown layer with tiny pieces and a scattering of pale green. Corrosion and its products will be examined in-depth in this study, which will assist us in better understanding the corrosive causes and degradation processes, as well as to identify the metals that comprise the chosen objects produced during long-term entombment. Both items' samples were investigated using Metallographic Microscope (ME) and Scanning Electron Microscope (SEM) for this purpose, while corrosion products were evaluated by using x-ray diffraction (XRD), while the bulk elements of the objects were determined using x-ray fluorescence (XRF). Copper, atacamite, and paratacamite have been identified by XRD analysis as the corrosion products of the leaded bronze alloy. Microscopy shows that the two items have been damaged in certain areas. Chemical cleaning was selected for the treatment of the artifacts based on the information gathered. To investigate the synergistic impact of adding 25 ppm of potassium iodide (KI) to the stock solution of the corrosion inhibitor sodium (Z)-4-oxo-4-p-tolyl-2-butenoate, in this work, the effect of potassium iodide as an improvement chemical was examined (SOTB). For the preservation of old leaded bronze items, this combination has been tested. Synergistic effects between KI and the chosen inhibitor were shown to be beneficial.
Colonoscopic laxative instillation for the fecal loaded colon: A Case Series
Authors: Wagle Suhas D. , Wagle Aneeta S. 
Published: September 2022

Abstract

Context:
Post-operative, critically ill, and elderly patients often have fecal loading or impaction. In a few such patients, disimpaction of fecalomas and colon cleansing is difficult. Bowel obstruction, megacolon, lower gastrointestinal bleeding, and gut perforation are complications that may ensue. Oral laxatives or enemas may only be partially effective. Surgical intervention may be needed for salvage or for complications.
Series and Design:
Fourteen hospitalized cases with defecation disorder due to fecal loading of the colon were enrolled for retrospective analysis. Colonoscopic instillation of mannitol and /or lactulose was undertaken as an intervention when the use of oral laxatives was either ineffective or unfeasible, and enema too had yielded poor results.
Results
Ten patients had satisfactory outcomes for feal clearance, whereas four patients with poor or incomplete responses underwent repeat interventions or surgery. No significant complications were encountered due to this therapy.
Conclusion
Colonoscopic instillation of mannitol or lactulose in fecal loaded critically ill patients, results in a safe and satisfactory fecal clearance.
WITHDRAWN: Pilot Pattern Optimization of OFDM Sparse Channel Estimation Based on Enhanced Butterfly Optimization Algorithm
Authors: Li Ning , YU Wenhan , Deng Zhongliang 
Published: September 2022

Abstract
Pilot pattern has an important impact on the performance of channel estimation based on compressed sensing. However, due to the limitations of time and space, the traditional enumeration methods and existing heuristic methods have some limitations in practical application. This paper proposes an enhanced butterfly optimization algorithm (EBOA) to solve this problem. EBOA is based on the butterfly optimization algorithm (BOA). In view of the problems that the BOA algorithm is prone to local optimal and slow convergence speed, EBOA improves the optimization efficiency and robustness by introducing the optimization strategy of good point set, designing adaptive switching probability and t-distribution variation factor, and applies it to pilot pattern optimization. Experiments show that compared with butterfly optimization algorithm (BOA), estimation of distribution algorithm (EDA), Particle swarm optimization (PSO), salp swarm algorithm (SSA), the EBOA algorithm proposed in this paper can generate a measurement matrix with less cross-correlation, and the corresponding optimized pilot mode is better than other methods in bit error rate and mean square error.
Nonextensive realizations in interacting ion channels: implications for mechano-electrical transducer mechanisms.
Authors: Santos Danielle O. C. , Trindade Marco Antônio S. , Silva Adriano J. da 
Published: September 2022

Abstract
Although there are theoretical studies on the thermodynamics of ion channels, an investigation involving the thermodynamics of coupled channels has not been proposed. To overcome this issue, we developed calculations to present a thermodynamic scenario associated with mechanoelectrical transduction channels as a single and coupling of two-state channels. The modeling was inspired by the Tsallis theory, in which we derived the open and closed probability distributions, the joint probability distribution, the Tsallis entropy, and the Shannon mutual information. Despite being well studied in many biological systems, the literature has not addressed both entropy and mutual information related to isolated and a pair of physically interacting mechanoelectrical transduction channels. Inspired by the hair cell biophysics, we revealed how the presence of nonextensivity modulates the degree of entropy and mutual information as a function of stereocilia displacements. In this sense, we showed how the non-extensivity regulates the current versus displacement curve for a single and two interacting channels made up of a single open and closed states. Overall, subadditivity and superadditivity yielded increments and decrements in the entropy and mutual information compared with the extensive regime. We also observed that the magnitude of the interaction between the two channels significantly influences the amplitude of the joint entropy and the mutual information. These results are directly related to the modulation of the channel kinetics, given by changes evoked by hair cell displacements. Finally, we found that the gating force modulates the contribution of subadditivity and superadditivity present in the joint entropy and the mutual information. The present findings shed light on the thermodynamic process involved in the molecular mechanisms of the auditory system.
Indoor lightweight semantic segmentation network based on Mask R-CNN
Authors: LIAN Xiaofeng , XU Chenxing , LUO Haiyong , TAN Li 
Published: September 2022

Abstract
Slow semantic segmentation speed in the semantic SLAM, Low real-time performance, excessive occupation of resources and other problems, A lightweight Mask R-CNN network with an adaptive channel attention mechanism is proposed since the original semantic segmentation network is complex in the residual network. And the application environment is indoor, The environment is relatively simple. Therefore, the lightweight network improves the ResNet-50 in the original complex backbone network (backbone) by using deep separable convolution and packet convolution to a more lightweight ResNet-SD-tiny. And add the adaptive channel attention mechanism. In the adaptive channel attention module of the model, the weight of RGB information to RGB information in a weighted way, by increasing the cascade of empty space convolution, the parameter weight of the traditional feature pyramid pooling module is reduced, reducing the real-time acquisition of the RGB information features.