bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimal handgrip force is needed for transcutaneous electrical stimulation to improve hand functions of patients with severe spinal cord injury
Authors: Huang Ruyi , Nikooyan Ali A. , Moore Lisa D. , Zdunowski Sharon , Morikawa Erika , Sierro Tiffany , Sayenko Dimitry , Gad Parag , Homsey Tali , Le Timothy , Madhavan Meghna A. , Abdelshahid Marina , Abdelshahid Martina , Zhou Yan , Nuwer Mark R. , Sarrafzadeh Majid , Edgerton V. Reggie , Leiter James C. , Lu Daniel C. 
Published: May 2022

AbstractSpinal cord stimulation enhanced restoration of motor function following spinal cord injury (SCI) in unblinded studies. To determine whether training combined with transcutaneous electrical spinal cord stimulation (tSCS), with or without systemic serotonergic treatment with buspirone (busp), could improve hand function in individuals with severe hand paralysis following SCI, we assessed ten subjects in a double-blind, sham-controlled, crossover study. All treatments—busp, tSCS, and the busp plus tSCS—reduced muscle tone and spasm frequency. Buspirone did not have any discernible impact on grip force or manual dexterity when administered alone or in combination with tSCS. In contrast, grip force, sinusoidal force generation and grip-release rate improved significantly after 6 weeks of tSCS in 5 out of 10 subjects who had residual grip force within the range of 0.1–1.5 N at the baseline evaluation. Improved hand function was sustained in subjects with residual grip force 2–5 months after the tSCS and buspirone treatment. We conclude that tSCS combined with training improves hand strength and manual dexterity in subjects with SCI who have residual grip strength greater than 0.1 N. Buspirone did not significantly improve the hand function nor add to the effect of stimulation.
Perceptually motivated loss functions for computer generated holographic displays
Authors: Yang Fan , Kadis Andrew , Mouthaan Ralf , Wetherfield Benjamin , Kaczorowski Andrzej , Wilkinson Timothy D. 
Published: May 2022

AbstractUnderstanding and improving the perceived quality of reconstructed images is key to developing computer-generated holography algorithms for high-fidelity holographic displays. However, current algorithms are typically optimized using mean squared error, which is widely criticized for its poor correlation with perceptual quality. In our work, we present a comprehensive analysis of employing contemporary image quality metrics (IQM) as loss functions in the hologram optimization process. Extensive objective and subjective assessment of experimentally reconstructed images reveal the relative performance of IQM losses for hologram optimization. Our results reveal that the perceived image quality improves considerably when the appropriate IQM loss function is used, highlighting the value of developing perceptually-motivated loss functions for hologram optimization.
Optimization of DMD-based independent amplitude and phase modulation by analysis of target complex wavefront
Authors: Georgieva Alexandra , Belashov Andrey V. , Petrov Nikolay V. 
Published: May 2022

AbstractThe paper presents the results of a comprehensive study on the optimization of independent amplitude and phase wavefront manipulation which is implemented using a binary digital micromirror device. The study aims to investigate the spatial resolution and quantization achievable using this approach and its optimization based on the parameters of the target complex wave and the modulation error estimation. Based on a statistical analysis of the data, an algorithm for selecting parameters (carrier frequency of binary pattern and aperture for the first diffraction order filtering) that ensures the optimal quality of the modulated wavefront was developed. The algorithm takes into account the type of modulation, that is, amplitude, phase, or amplitude-phase, the size of the encoded distribution, and its requirements for spatial resolution and quantization. The results of the study will greatly contribute to the improvement of modulated wavefront quality in various applications with different requirements for spatial resolution and quantization.
Foveal hypoplasia and characteristics of optical components in patients with familial exudative vitreoretinopathy and retinopathy of prematurity
Authors: Chen Pei-Ying , Kang Eugene Yu-Chuan , Chen Kuan-Jen , Ling Xiao Chun , Chang Yin-Hsi , Wang Nan-Kai , Liu Laura , Chen Yen-Po , Hwang Yih-Shiou , Lai Chi-Chun , Wu Wei-Chi 
Published: May 2022

AbstractThere has been limited research regarding the status of foveal hypoplasia and the characteristics of the optical components of the eye in patients with familial exudative vitreoretinopathy (FEVR) and retinopathy of prematurity (ROP). In this retrospective cohort study, patients were classified into five groups: patients with stage 1 and 2 FEVR (FEVR group), patients with ROP who received treatment (treated ROP group), patients with ROP who did not receive treatment (untreated ROP group), patients without ROP who had been born preterm (preterm group), and healthy patients who had been born at term (full-term group). Visual acuity, refractive error, characteristics of the optical components, and features of the fovea were compared. In total, 179 eyes from 100 patients were included. Patients in the FEVR group had the highest degrees of myopia (p < 0.001). The axial length of patients in the FEVR group was significantly longer than that of patients in the treated and untreated ROP, preterm, and full-term groups (p < 0.001, p < 0.001, p = 0.001, and p = 0.003, respectively). Patients in the FEVR group had a higher proportion of grade 4 foveal hypoplasia and thinner foveae than those in the other groups (p < 0.001). Patients with FEVR had significantly greater myopic change than patients with ROP; the significantly longer axial length of the FEVR group might be the reason for the greater myopic change and lesser macular thickness. Patients in the FEVR group had more foveal hypoplasia than those in the other groups.
Design and evaluation of 3D-printed auxetic structures coated by CWPU/graphene as strain sensor
Authors: Choi Hyeong Yeol , Shin Eun Joo , Lee Sun Hee 
Published: May 2022

AbstractA strain sensor characterized by elasticity has recently been studied in various ways to be applied to monitoring humans or robots. Here, 4 types of 3D-printed auxetic lattice structures using thermoplastic polyurethane as raw material were characterized: truss and honeycomb with positive Poisson's ratio and chiral truss and re-entrant with negative Poisson's ratio. Each structure was fabricated as a flexible and stable strain sensor by coating graphene through a dip-coating process. The fabricated auxetic structures have excellent strength, flexibility, and electrical conductivity desirable for a strain sensor and detect a constant change in resistance at a given strain. The 3D-printed auxetic lattice 4 type structures coated with CWPU/Graphene suggest potential applications of multifunctional strain sensors under deformation.
A statistical shape model of soleus muscle morphology in spastic cerebral palsy
Authors: Bin Ghouth Salim G. , Williams Sian A. , Reid Siobhan L. , Besier Thor F. , Handsfield Geoffrey G. 
Published: May 2022

AbstractThis study investigated morphological characteristics of the soleus muscle in cerebral palsy (CP) and typically developing (TD) cohorts using a statistical shape model and differentiated dominant features between the two cohorts. We generated shape models of CP and TD cohorts to characterize dominant features within each. We then generated a combined shape model of both CP and TD to assess deviations of the cohorts’ soleuses from a common mean shape, and statistically analysed differences between the cohorts. The shape models revealed similar principal components (PCs) with different variance between groups. The CP shape model yielded a distinct feature (superior–inferior shift of the broad central region) accounting for 8.1% of the model’s cumulative variance. The combined shape model presented two PCs where differences arose between CP and TD cohorts: size and aspect ratio of length–width–thickness. The distinct appearance characteristic in the CP model—described above—may implicate impaired muscle function in children with CP. Overall, children with CP had smaller muscles that also tended to be long, thin, and narrow. Shape modelling captures dominant morphological features of structures, which was used here to quantitatively describe CP muscles and further probe our understanding of the disease’s impact on the muscular system.
Nature and happiness in an individualist and a collectivist culture
Authors: Svoray Tal , Dorman Michael , Abu-Kaf Sarah , Shahar Golan , Gifford Robert 
Published: May 2022

AbstractAccording to the attention restoration theory, exposure to nature (ETN) renews one's capacity to focus attention, which decreases cognitive fatigue and therefore may increase positive emotions. Indeed, natural settings have been associated with high prevalence of happy facial expressions (HFE). However, how universal the association is, remains unclear. We explored the ETN-HFE association in Boston, US, representing a less collectivistic culture, and Yokohama, Japan, representing a more collectivistic one. Evidence from satellite images and social network data, using geoinformatics and statistical tools, revealed that individuals from both societies exhibited more happiness when they were photographed in more natural settings. These associations varied with temporal variations expressed through weekly and annual effects. In addition, we found that the presence of others was also associated with prevalence of HFE in natural settings at Yokohama and Boston but the relation was significantly stronger in Boston. Despite some relatively minor differences between the countries, these results support the universality of the association between ETN and HFE.
Identification of an interactome network between lncRNAs and miRNAs in thyroid cancer reveals SPTY2D1-AS1 as a new tumor suppressor
Authors: Ramírez-Moya Julia , Wert-Lamas León , Acuña-Ruíz Adrián , Fletcher Alice , Wert-Carvajal Carlos , McCabe Christopher J. , Santisteban Pilar , Riesco-Eizaguirre Garcilaso 
Published: May 2022

AbstractThyroid cancer is the most common primary endocrine malignancy in adults and its incidence is rapidly increasing. Long non-coding RNAs (lncRNAs), generally defined as RNA molecules longer than 200 nucleotides with no protein-encoding capacity, are highly tissue-specific molecules that serve important roles in gene regulation through a variety of different mechanisms, including acting as competing endogenous RNAs (ceRNAs) that ‘sponge’ microRNAs (miRNAs). In the present study, using an integrated approach through RNA-sequencing of paired thyroid tumor and non-tumor samples, we have identified an interactome network between lncRNAs and miRNAs and examined the functional consequences in vitro and in vivo of one of such interactions. We have identified a likely operative post-transcriptional regulatory network in which the downregulated lncRNA, SPTY2D1-AS1, is predicted to target the most abundant and upregulated miRNAs in thyroid cancer, particularly miR-221, a well-known oncomiRNA in cancer. Indeed, SPTY2D1-AS1 functions as a potent tumor suppressor in vitro and in vivo, it is downregulated in the most advanced stages of human thyroid cancer, and it seems to block the processing of the primary form of miR-221. Overall, our results link SPTY2D1-AS1 to thyroid cancer progression and highlight the potential use of this lncRNA as a therapeutic target of thyroid cancer.
Alpha and beta phylogenetic diversities jointly reveal ant community assembly mechanisms along a tropical elevational gradient
Authors: Pérez-Toledo Gibran Renoy , Villalobos Fabricio , Silva Rogerio R. , Moreno Claudia E. , Pie Marcio R. , Valenzuela-González Jorge E. 
Published: May 2022

AbstractDespite the long-standing interest in the organization of ant communities across elevational gradients, few studies have incorporated the evolutionary information to understand the historical processes that underlay such patterns. Through the evaluation of phylogenetic α and β-diversity, we analyzed the structure of leaf-litter ant communities along the Cofre de Perote mountain in Mexico and evaluated whether deterministic- (i.e., habitat filtering, interspecific competition) or stochastic-driven processes (i.e., dispersal limitation) were driving the observed patterns. Lowland and some highland sites showed phylogenetic clustering, whereas intermediate elevations and the highest site presented phylogenetic overdispersion. We infer that strong environmental constraints found at the bottom and the top elevations are favoring closely-related species to prevail at those elevations. Conversely, less stressful climatic conditions at intermediate elevations suggest interspecific interactions are more important in these environments. Total phylogenetic dissimilarity was driven by the turnover component, indicating that the turnover of ant species along the mountain is actually shifts of lineages adapted to particular locations resembling their ancestral niche. The greater phylogenetic dissimilarity between communities was related to greater temperature differences probably due to narrow thermal tolerances inherent to several ant lineages that evolved in more stable conditions. Our results suggest that the interplay between environmental filtering, interspecific competition and habitat specialization plays an important role in the assembly of leaf-litter ant communities along elevational gradients.
Socially induced false memories in the absence of misinformation
Authors: Wagner Ullrich , Schlechter Pascal , Echterhoff Gerald 
Published: May 2022

AbstractAmple evidence shows that post-encoding misinformation from others can induce false memories. Here, we demonstrate in two experiments a new, tacit form of socially generated false memories, resulting from interpersonal co-monitoring at encoding without communication of misinformation. Pairs of participants jointly viewed semantically coherent word lists, presented successively in blue, green, or red letters. Each individual was instructed to memorize words presented in one of the colors. One color remained unassigned (control condition). Participants (total N = 113) reported more false memories for non-presented words (lures) semantically related to partner-assigned than to control lists, although both list types were equally irrelevant to their own task. Notably, this effect also persisted for particularly rich memories. These findings show for the first time that social induction of false memories, even subjectively rich ones, does not necessarily require communication of deceptive information. This has important implications both theoretically and practically (e.g., in forensic contexts).
Cyanidin-3-O-glucoside inhibits the β-catenin/MGMT pathway by upregulating miR-214-5p to reverse chemotherapy resistance in glioma cells
Authors: Zhou Yuan , Chen Li , Ding Deping , Li Ziheng , Cheng Li , You Qiuyun , Zhang Shunbo 
Published: May 2022

AbstractOvercoming resistance to alkylating agents has important clinical significance in glioma. Cyanidin-3-O-glucoside (C3G) has a tumor-suppressive effect on tumor cells. However, whether it plays a role in temozolomide resistance in glioma is still unclear. We constructed a TMZ-resistant LN-18/TR glioma cell line, observed the effect of C3G on TMZ resistance in this cell line, and explored the role of miR-214-5p in chemoresistance. Results showed that β-catenin and MGMT were significantly upregulated in LN-18/TR cells. C3G upregulated miR-214-5p and enhanced the cytotoxic effect of temozolomide on LN-18/TR cells. Contrarily, C3G downregulated β-catenin and MGMT. Moreover, the miR-214-5p mimic downregulated β-catenin and MGMT in LN-18/TR cells, whereas the miR-214-5p inhibitor had the opposite effect; the miR-214-5p inhibitor significantly blocked the C3G-induced downregulation of β-catenin and MGMT. C3G or the miR-214-5p mimic enhanced temozolomide-induced apoptosis in LN-18/TR cells, whereas the miR-214-5p inhibitor blocked this effect. Furthermore, C3G or miR-214-5p agomir combined with TMZ significantly inhibited the growth of LN-18/TR tumors. Collectively, our research discovered the potential signaling mechanism associated with C3G-mediated suppression of TMZ resistance in LN-18/TR cells through miR-214-5p, which can facilitate the treatment of MGMT-induced resistance in glioma cells.
Performance assessment across different care settings of a heart failure hospitalisation risk-score for type 2 diabetes using administrative claims
Authors: Guazzo Alessandro , Longato Enrico , Morieri Mario Luca , Sparacino Giovanni , Franco-Novelletto Bruno , Cancian Maurizio , Fusello Massimo , Tramontan Lara , Battaggia Alessandro , Avogaro Angelo , Fadini Gian Paolo , Di Camillo Barbara 
Published: May 2022

AbstractPredicting the risk of cardiovascular complications, in particular heart failure hospitalisation (HHF), can improve the management of type 2 diabetes (T2D). Most predictive models proposed so far rely on clinical data not available at the higher Institutional level. Therefore, it is of interest to assess the risk of HHF in people with T2D using administrative claims data only, which are more easily obtainable and could allow public health systems to identify high-risk individuals. In this paper, the administrative claims of > 175,000 patients with T2D were used to develop a new risk score for HHF based on Cox regression. Internal validation on the administrative data cohort yielded satisfactory results in terms of discrimination (max AUROC = 0.792, C-index = 0.786) and calibration (Hosmer–Lemeshow testpvalue < 0.05). The risk score was then tested on data gathered from two independent centers (one diabetes outpatient clinic and one primary care network) to demonstrate its applicability to different care settings in the medium-long term. Thanks to the large size and broad demographics of the administrative dataset used for training, the proposed model was able to predict HHF without significant performance loss concerning bespoke models developed within each setting using more informative, but harder-to-acquire clinical variables.
Redox signaling induces laminin receptor ribosomal protein-SA expression to improve cell adhesion following radiofrequency glow discharge treatments
Authors: Ponnusamy Sasikumar , Ali Hanan H. , Dutt Felisha , Rahman Saeed Ur , Salah Ahmad A. , Pipalia Mahek , Baier Robert E. , Arany Praveen R. 
Published: May 2022

AbstractCurrent biomaterials effectively replace biological structures but are limited by infections and long-term material failures. This study examined the molecular mechanisms of radio frequency glow discharge treatments (RFGDT) in mediating the disinfection of biomaterial surfaces and concurrently promoting cell attachment and proliferation. Dental biomaterials were subjected to RFGDT, and viability of oral microbial species, namelyStreptococcus mutants(SM),Streptococcus gordonii(SG),Moraxella catarrhalis(MC), andPorphyromonas gingivalis(PG), were assessed. Cell attachment and survival of a pre-odontoblast cell line, MDPC-23, was examined. Finally, mechanistic investigations into redox generation and biological signaling were investigated. Based on their compositions, dental biomaterials induced reactive oxygen species (ROS) following dose-dependent RFGDT. Reduced microbial viability was evident following RFGDT in the catalase-negative (SM and SG) species more prominently than catalase-positive (MC and PG) species. Cell adhesion assays noted improved MDPC-23 attachment and survival. Pretreatments with N-acetylcysteine (NAC) and catalase abrogated these responses. Immunoassays noted redox-induced downstream expression of a laminin receptor, Ribosomal Protein SA, following RFGDT. Thus, RFGDT-induced redox mediates antimicrobial and improves cell responses such as adhesion and proliferation. These observations together provide a mechanistic rationale for the clinical utility of RFGDT with dental biomaterials for regenerative clinical applications.
Real-time complex light field generation through a multi-core fiber with deep learning
Authors: Sun Jiawei , Wu Jiachen , Koukourakis Nektarios , Cao Liangcai , Kuschmierz Robert , Czarske Juergen 
Published: May 2022

AbstractThe generation of tailored complex light fields with multi-core fiber (MCF) lensless microendoscopes is widely used in biomedicine. However, the computer-generated holograms (CGHs) used for such applications are typically generated by iterative algorithms, which demand high computation effort, limiting advanced applications like fiber-optic cell manipulation. The random and discrete distribution of the fiber cores in an MCF induces strong spatial aliasing to the CGHs, hence, an approach that can rapidly generate tailored CGHs for MCFs is highly demanded. We demonstrate a novel deep neural network—CoreNet, providing accurate tailored CGHs generation for MCFs at a near video rate. The CoreNet is trained by unsupervised learning and speeds up the computation time by two magnitudes with high fidelity light field generation compared to the previously reported CGH algorithms for MCFs. Real-time generated tailored CGHs are on-the-fly loaded to the phase-only spatial light modulator (SLM) for near video-rate complex light fields generation through the MCF microendoscope. This paves the avenue for real-time cell rotation and several further applications that require real-time high-fidelity light delivery in biomedicine.
Reef larval recruitment in response to seascape dynamics in the SW Atlantic
Authors: de Azevedo Mazzuco Ana Carolina , Fraga Bernardino Angelo 
Published: May 2022

AbstractAdvances in satellite observation have improved our capacity to track changes in the ocean with numerous ecological and conservation applications, which are yet under-explored for coastal ecology. In this study, we assessed the spatio-temporal dynamics in invertebrate larval recruitment and the Seascape Pelagic Habitat Classification, a satellite remote-sensing product developed by the Marine Biodiversity Observation Network (MBON) and delivered by the US National Oceanic and Atmospheric Administration to monitor biodiversity globally. Our ultimate goal was to identify and predict changes in coastal benthic assemblages at tropical reefs in the SW Atlantic based on integrated pelagic conditions, testing the use of MBON Seascape categorization. Our results revealed that the pelagic Seascapes correlated with monthly and seasonal variations in recruitment rates and assemblage composition. Recruitment was strongly influenced by subtropical Seascapes and was reduced by the presence of warm waters with high-nutrient contents and phytoplankton blooms, which are likely to affect reef communities in the long term. Recruitment modeling indicates that Seascapes may be more efficient than sea surface temperature in predicting benthic larval dynamics. Based on historical Seascape patterns, we identified seven events that may have impacted benthic recruitment in this region during the last decades. These findings provide new insights into the application of novel satellite remote-sensing Seascape categorizations in benthic ecology and evidence how reef larval supply in the SW Atlantic could be impacted by recent and future ocean changes.