bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustained activation of EGFR-ERK1/2 signaling limits the therapeutic response to tigecycline-induced inhibition of mitochondrial translation in liver cancer
Authors: Qin Wenxin , Zhou Yangyang , Wang Siying , Wu Wei , Ling Jing , Li Haoyu , Jia Qi , Zheng Jiaojiao , Zheng Xingling , Yu Ruobing , Wu Qiangxin , Shi Yaoping , Lieftink Cor , Beijersbergen Roderick , Yuan Sheng-xian , Bernards Rene , Jin Haojie 
Published: March 2022

Abstract
Treatment of advanced liver cancer still faces great challenges. Identification of tumor dependencies is important for developing novel therapeutic strategies for liver cancer. Here, we identified mitochondrial translation as a major vulnerability of liver cancer by genome-wide CRISPR screen. Targeting mitochondrial translation by tigecycline showed therapeutic potential in liver cancer. Then, a compounds screen was applied to identify MEK inhibitors as synergistic drugs to tigecycline-insensitive liver cancer cells. Mechanistically, sustained activation of EGFR-ERK1/2-MYC cascade conferred the insensitivity to tigecycline, which was mediated by enhanced secretion of EREG and AREG. Moreover, glycolytic enzymes, such as HK2 and PKM2, and mitochondrial one-carbon enzyme SHMT2 were upregulated to stimulate glycolysis and maintain mitochondrial function, respectively, in a MYC-dependent manner. Tigecycline in combination with MEK inhibitor trametinib or EGFR inhibitor gefitinib showed synergistic antitumor effect in vitro and in vivo. Thus, our study provides a potential therapeutic strategy for liver cancer.
Real-life effectiveness of dupilumab in patients with mild to moderate bronchial asthma comorbid with CRSwNP
Authors: Minagawa Shunsuke , Araya Jun , Watanabe Naoaki , Fujimoto Shota , Watanabe Junko , Hara Hiromichi , Numata Takanori , Kuwano Kazuyoshi , Matsuwaki Yoshinori 
Published: March 2022

Abstract
(Background) Dupilumab, an anti-IL-4α receptor antibody, is a new treatment for severe or refractory asthma, but real-world evidence is lacking for the efficacy of dupilumab in patients with mild to moderate bronchial asthma.(Methods) We retrospectively evaluated the effect of dupilumab in 62 patients received with dupilumab for eosinophilic sinusitis comorbid with asthma at a single center in Japan. Type 2 inflammatory markers, ACT, respiratory function tests, and forced oscillation technique (FOT) were analyzed before, three months after, and one year after dupilumab administration, mainly in patients with mild to moderate asthma.(Results) FEV1, %FEV1, %FVC, treatment step for asthma and ACT improved significantly after three months of dupilumab treatment. FeNO was markedly decreased, whereas IgE and eosinophil counts showed no significant changes. Pre and post-treatment respiratory resistance (Rrs) and respiratory reactance (Xrs) correlated significantly with FEV1. Improvement in %FEV1 was associated with higher FeNO and higher serum IgE before dupilumab treatment.(Conclusion) Dupilumab treatment for sinusitis may benefit respiratory function, asthma symptoms, and asthma treatment reduction, even if the associated bronchial asthma is not severe.
Strabismus surgery improves the quality of life of strabismus patients with thyroid-associated ophthalmopathy
Authors: Chen Jinmao , Huang Yihua , Li Kaijun , Yan Yuqing , He Jianfeng 
Published: March 2022

Abstract
Background The effect of strabismus surgery on the quality of life of strabismus patients with thyroid-associated ophthalmopathy is unclear, The aim of the study is to explore the effect of strabismus surgery on the quality of life of strabismus patients with quiescent thyroid-associated ophthalmopathy (TAO).Methods This study is a prospective case-series study. Strabismus patients with TAO who were admitted in the First Affiliated Hospital of Guangxi Medical University from October 2011 to April 2016 were included in this study. The patients completed the Graves' ophthalmopathy quality of life questionnaire (GO-QOL) before the operation and 6 weeks after the operation. Preoperative and postoperative quality of GO-QOL scores were compared using paired samples t-test. The correlation between the angle of misalignment and the quality of life was analyzed using Spearman correlation analysis.Results We recruited 23 patients for this study, including 11 males and 12 females. Patients were 31-67 years old with a mean age of 49.04 years. Compared to preoperative GO-QOL scores, postoperative GO-QOL scores for visual function (43.04 vs. 73.50, p<0.001) and psychosocial function (40.13 vs. 72.93, p<0.001 ) were significantly increased, respectively. The greater the preoperative angle of misalignment was, the worse the psychosocial function (r= -0.433, p=0.039).Conclusions Strabismus surgery significantly improves the quality of life of the strabismus patients with quiescent TAO.
Cutting Error Detection and Compensation Control System of Roadheader Based on 3D Laser Scanning
Authors: LIU Zhi-xiang , WANG He , XIE Miao , XIE Chun-xue 
Published: March 2022

Abstract
Considering memory occupation and large amount of operation of the conventional coal mine roadway 3D point cloud information map modeling method, studied the roadheader cutting error detection and compensation control system based on 3D laser scanning. A driving roadway space modeling method based on point cloud data and 3D grid mapping is proposed. the roadway space is divided into limited grids to form a three-dimensional raster map of roadway space, and 3D grid is divided into multiple functional areas. Through the conversion between 3D lidar coordinate system and roadway coordinate system, the point cloud data measured by 3D lidar can be converted into roadway contour data. Cutting error compensation control model is established to realize the compensation control of roadheader cutting underexcavation. Through the experimental verification, when three-dimensional grid side length size is set to 10cm, raster map obtained by the cutting forming roadway 3D raster map modeling method in this paper is used to guide the operation of the roadheader cutting system, which can reduce the data processing capacity by 84.7% compared with the conventional point cloud map. It is verified that the method can be used to compensate and cut the underexcavated surrounding rock of the roadway.
Protect peanut kernels from Aspergillus spp and their mycotoxins during storage by aqueous extract of carob pulp
Authors: El-Desouky Tarek A. 
Published: March 2022

Abstract
Recently, the trend of many studies to replace synthetic antifungals commonly used during storage with natural antifungals; Plants extracts are one of the promising strategies for this purpose. Therefore, this study aimed to evaluate the aqueous extract of carob pulp (AECP) at 1.5, 2.5, and 5mg/ml on the growth of some toxigenic Aspergillus species, and its effectiveness as antimycotoxigenic (aflatoxins and ochratoxin A) during storage red peanut kernels (RPKs) for 90 days. AECP at 5 mg/ml affected inhibition growth, as Aspergillus ochraceus was the most affected, then A. aflatoxiformans recorded (15.7 ± 0.4) and (13.4 ± 0.5), respectively. Whereas study influence of AECP on the accumulation of total AFs and OTA produced by A. parasiticus and A. ochraceus during the storage of RPKs for 90 days. The results reflected that the active compounds in the AECP can protect RPKs for 45 days without detecting any amounts of total AFs and OTA at 5mg/ml. While after 90 days, the percentages of inhibition for the four types (AFB1, AFG1, AFB2, AFG2) and OTA after storage for 90 days compared with positive control samples (85.1, 76.5, 86.5,84.2, and 87.5%), respectively. Finally, AFB1 recorded the lowest inhibition percentages with all treatments; on the contrary, it was OTA.
Self-extracted corn-stalk cellulose/epoxy resin composites
Authors: Lou Chunhua , Jiang siyu , Yan an , Zhou Yongli , Liu Yang , Zhang yong 
Published: March 2022

Abstract
In order to make full use of crop waste stalk, corn-stalk cellulose (CSC) was extracted by acid-base method and used as modifier of epoxy resin (E51) to prepare the self-extracted corn-stalk cellulose / epoxy resin composites (CSCEC). Thermogravimetry (TG) analysis, dynamic mechanical analysis (DMA), morphology analysis by scanning electron microscope (SEM), the mechanical properties by electronic universal testing machine and impact testing machine were used for characterization and analysis. The experimental results showed that when the CSC content was 20 wt%, the impact strength of the composite was 2.50 kJ /m2, which was 127.2% higher than that of pure epoxy resin. Meanwhile, the tensile and bending strength were slightly increased, and the storage modulus (E') of epoxy resin was also slightly increased, indicating that the addition of CSC could toughen the epoxy resin. When the CSC content was 20 wt%, the Tg of epoxy resin obtained by DMA was the lowest, 167.4 ℃, which decreased by 11.3 ℃ compared with that of pure epoxy resin.
Organic-inorganic hybrid material [(C2H5)4N]2ZnI4: Synthesis, thermal behavior and spectroscopic studies
Authors: Elgahami Hanen , Lhoste Jerome , Auduste Sandy , Corbel Gwenael , Oueslati Abderrazek 
Published: March 2022

Abstract
The bis (tetra-ethylammonium) tetraiodo-zincate (II) was prepared by slowly evaporating an aqueous stoichiometric mixture of tetra-ethylammonium iodide and zinc iodide at room temperature. X-ray diffraction (XRD), thermal analysis, UV-vis spectroscopy and complex impedance spectroscopy were used to fully characterize this compound. Single-crystal X-ray diffraction analysis indicates that the compound crystallizes at room temperature in the tetragonal system, space group P \(\stackrel{-}{4}\)21m(No.113), with lattice parameters a = 13.794 (2) Å and c = 14.900 (3) Å. Differential thermal analysis (DTA) and temperature-controlled X-ray diffraction study revealed a reversible first order phase transition at about 444 K between low and high temperature forms of [(C2H5)4N]2ZnI4. Below 444 K, the low temperature form exhibits two linear regimes of thermal expansion with a change at around 373Kascribed to a second-order phase transition. The diffuse reflectance indicates the existence of optical direct allowed transition mechanisms with the band gap energy equal to 3.9 eV.Complex impedance spectra recorded in the temperature range of 403 to 468 K were satisfactorily modelled by acombination of R//CPE elements assigned tothe electrical response of grains at the first order phase transition at around 444 K, a change of conduction regime is noted in the temperature dependence of DC-conductivity. In both regimes, the conductivity obeys the Arrhenius law with activation energies of 1.37 eV in regime I and 2.37 eVin regime II.The frequency dependent AC-conductivity followed the universal Jonscher’s power law.
To study the scope of drone usage for disaster management in India with respect to the USA with a comparison of economic factors including the GDP, the level of unemployment and inflation, and the government regulations.
Authors: Chordia Kashish , Bhagwatkar Dhruv , Fernandes Dominique , Gill Angad , Jaju Aayush 
Published: March 2022

Abstract
The use of unmanned aerial vehicles (UAVs), also called drones, is growing rapidly across many domains, including disaster management. Developed countries like the USA have been increasingly investing in their drone technology to reap maximum benefits in the future. Since the usage of UAVs is the next big revolution, developing countries like India have also started to map the potential of this industry. The Indian government has cautiously started to use drones to combat natural disasters like cyclones and provide after-relief services on multiple occasions. Both the US and India experience countless natural calamities each year given their geographic conditions. While the US has moved towards extensive drone usage to combat these disasters, India is still struggling with its drone industry. Given the stage of the economy and the post-pandemic recovery, it is necessary to study the extent to which India can invest in drone technology when compared to the US on the basis of its economy. Moreover, besides the economy, the government regulations largely govern the functioning of an industry in a given country; on one side, where the US has extensively promoted the use of drones and eased the regulations, India still follows a slightly rigid approach to it. Hence, studying the future of these regulations and the Indian economy in general with one of the leading economies, i.e. the US, in consideration would help us to get a better understanding of both - the future of the drone industry in India and the scope of its growth in terms of disaster management.
Isoetid mediated radial oxygen loss prevents iron reduction and the related mobilisation of ammonium and methane: an experimental approach.
Authors: Doorn Jelmer van , Lucassen Esther , Harpenslager Sarah Faye , Santbergen Lennart , Roelofs Jan , Smolders Fons 
Published: March 2022

Abstract
Isoetids are slow growing ecosystem-engineers that maintain an oligotrophic environment through high radial oxygen losses (ROL) from their roots, which could potentially reduce methane (CH4) emission by promoting CH4 oxidation. Isoetid vegetations have declined in many European countries as an effect of eutrophication and inorganic carbon enrichment. To assess the effect of sudden disappearance of isoetids on biogeochemical carbon and nutrient cycling in organically rich sediments, we set up a greenhouse experiment. Intact vegetated sediment patches with Lobelia dortmanna and Litorella uniflora were collected from ten boreal Norwegian softwater lakes. For half of the patches, isoetids were manually removed. We determined the effect of removal on sediment redox potential, nitrogen (N), phosphorus (P), inorganic carbon availability and CH4 emission. In addition, germination success of L. dortmanna seeds was tested on the sediments where isoetids were removed. The absence of ROL after isoetid removal led to a drop in sediment redox potential, resulting in anaerobic breakdown of organic matter using alternative electron acceptors, especially iron oxides. Consequently, increased pore water concentrations of ammonium (NH4+), P and CH4 were observed in sediments where isoetids had been removed compared to the isoetid vegetated sediments. Moreover, over 60 times higher emission of CH4 was observed from the sediments where isoetids had been removed. On the highly reduced sediments, the germination of L. dortmanna was hampered. When isoetids are unable to recolonize after disturbance events, it is expected that the absence of ROL eventually results in a longterm inrease in lake productivity and CH4 emission.
Passivity or Participation? A qualitative evidence synthesis for streaming clinically low acuity patients presenting in an acute care setting
Authors: Jones Katie , Davies Joseph , Nelson Kayleigh , Rance Jaynie 
Published: March 2022

Abstract
Introduction: Streaming low-acuity patients to alternative services is a common strategy with the aim to reduce pressure on ED. Objective: To examine qualitative research regarding patient experience and perspectives of streaming-style interventions aimed at patients deemed clinically low-acuity. Methods: A qualitative evidence synthesis following the SPICE protocol. Findings: There are few qualitative articles exploring patient experiences of streaming. However, patient-centric streaming or navigation services emerge as a mark of quality that may conceivably support patients to gain timely and appropriate access to care.
Synchronous occurrence of hepatocellular carcinoma and renal cell carcinoma: A case report
Authors: Eyuboglu Kayahan , Reis Murat Emre , Colak Fatih , Topaloglu Serdar , Cobanoglu Umit , Calik Adnan 
Published: March 2022

Abstract
The coexistence of two primary tumors is very rare. Additionally, hepatocellular carcinoma (HCC) and renal cell carcinoma (RCC) are even less frequent.An 81-year-old male patient had HCC and RCC synchronously. Surgery was performed primarily, as both tumors were suitable for resection. Adverse effects were observed during the patient's follow-up with adjuvant chemotherapy, and the treatment regimen was changed.This report presents the seventh case describing the treatment of synchronous double cancers of HCC and RCC. Although this rare condition shortens the patient’s life expectancy, our patient is alive even though he has a liver recurrence in the third month and is followed up to the 20th month.
Identifying behaviours for survival and wellness among people who use methamphetamine with opioids in British Columbia: A qualitative study
Authors: Corser Jenny , Palis Heather , Fleury Mathew , Lamb Jess , Lock Kurt , McDougall Jenny , Mehta Amiti , Newman Cheri , Spence Heather , Buxton Jane 
Published: March 2022

Abstract
Background: British Columbia has been in a state of public health emergency since 2016, due to the unprecedented numbers of overdoses and overdose deaths. Methamphetamine (MA) detection in illicit drug toxicity deaths increased from 14% in 2012 to 43% in 2020 suggesting a concerning trend of concurrent MA and opioid use in BC that reflects rising patterns identified across North America. People who use MA concurrently with opioids face an elevated risk of harm. This study aimed to identify behaviours of people who concurrently use MA and opioids practice to be safe.Methods: One-on-one semi-structured interviews were conducted by Peer Research Assistants in person and by telephone. Each interview lasted approximately 30-90 minutes and were recorded and later transcribed. Thematic analysis was carried out to identify patterns in the behaviours participants described as important to their safety in the context of concurrently using MA and opioidsResults: Participants (n=22) were distributed across the province with at least four participants from each of the five geographic health regions; 64% self-identified as men, and 50% self-identified as Indigenous. Daily MA use was reported by 72.7% of participants, and 67.3% reported using alone either often or always. From the data, we identified that participants made several considerations and adaptations in order to balance the perceived benefits and risks of their use of MA with opioids. Two overarching themes were identified to describe how participants adapted their use for survival and wellness: 1) Personal safety behaviours, and 2) interpersonal safety behaviours.Conclusions: This manuscript identified diversity in participants’ MA and opioid use (i.e. frequency, route of administration), and a subsequent range of behaviours that were performed to improve wellness and survival while using MA and opioids. Some of participants’ behaviours were practiced individually, while others relied peer support, or public health service provision. Participants identified many gaps in available services to meet their diverse needs. Harm reduction and treatment responses must be robust and adaptable to respond to the diversity of patterns of substance use among people who use opioids and MA concurrently, so as to not perpetuate harm and leave people behind.
Spatial relationships between fishes and amphibians: implications for conservation planning in a Neotropical Hotspot
Authors: Covre Amanda C. , Lourenço-de-Moraes Ricardo , Campos Felipe S. , Benedito Evanilde 
Published: March 2022

Abstract
Context: Species distribution patterns are widely used to guide conservation planning and are a central issue in ecology. The usefulness of spatial correlation analysis has been highlighted in several ecological applications so far. However, spatial assumptions in ecology are highly scale-dependent, in which geographical relationships between species diversity and distributions can have different conservation concerns. Objectives: An integrative landscape planning was designed to show the spatial distribution patterns of taxonomic and functional diversity of amphibians and fishes, from multiple species traits regarding morphology, life history, and behavior. Methods: We used spatial, morphological, and ecological data of amphibians and fishes to calculated the functional diversity and the spatial correlation of species.Results: Mapping results show that the higher taxonomic and functional diversity of fishes are concentrated in the West Atlantic Forest. Considering amphibians, they are located in the East portion of the biome. Spatial correlation of species indicates the regions of the Serra do Mar and the southern part of the Central Corridor as the main overlapped species distribution areas between both groups.Conclusions: New key conservation sites were reported within the Brazilian Atlantic Forest hotspot, revealing cross-taxon mismatches between terrestrial and freshwater ecosystems. This study offers useful spatial information integrating suitable habitats of fishes and amphibians to complement existing and future research based on terrestrial and freshwater conservation. New priorities for biodiversity conservation in rich-species regions highlight the importance of spatial pattern analysis to support land-use planning in a macroecological context.
Advances in surface plasmon resonance–based biosensor technologies for Cancer Cell detection
Authors: Karki Bhishma , Uniyal Arun , Pal Amrindra , Srivast Vivek 
Published: March 2022

Abstract
Efforts have been made to enhance the sensitivity of the conventional surface plasmon resonance biosensor. Two-dimensional heterostructure layer of titanium disilicide and black phosphorus has been deposited over the metal surface to improve the sensitivity. The titanium dis-ilicide (TiSi2) nanosheet is placed in between silver (Ag) and black phosphorus (BP) films in the Kretschmann arrangement. This biosen-sor executes better over a wide range of refractive index variations, including biological cell distribution in individual blood. It may become a fast method of detecting cancerous cells and the several variants of corona and other viruses that turn into a pandemic. Using finite element method based simulation technique, sensitivity obtained as are 195.4 deg/RIU, 167.6 deg/RIU, 212.4 deg/RIU, 168.4 deg/RIU, 212.4 deg/RIU, 186.6 deg/RIU, 218.6 deg/RIU, 195.4 deg/RIU, 203.6 deg/RIU, 202.6 deg/RIU 203.6 deg/RIU and 202.6 for sensing Basal (Skin Cancer), Basal (Normal Cell), Hela (Cervical Cancer) MCF-7 1 Springer Nature 2021 L A T E X template Article Title (Breast cancer), Hela (Normal Cell), Jurkat (Blood Cancer), Jurkat (Normal Cell), PCI-2 (Adrenal Gland Cancer), PCI-2 (Normal Cell), MDA-MB-231 (Breast Cancer), MDA-MB-231 (Normal Cell), MCF-7 (Breast Cancer) and MCF-7 (Normal Cell) respectively, and other performance parameters such as detection accuracy, quality factor and full width and half maximum (FWHM) are also evaluated.
Kernel-based iVAT with adaptive cluster extraction
Authors: Zhang Baojie , Zhu Ye , Rajasegarar Sutharshan , Li Gang , Liu Gang 
Published: March 2022

Abstract

Visual Assessment of cluster Tendency (VAT) is a popular method that visually represents the possible clusters found in a data set as dark blocks along the diagonal of a Reordered Dissimilarity Image (RDI). Although many variants of the VAT algorithm have been proposed to improve the visualisation quality on different types of datasets, they still suffer from the challenge of extracting clusters with varied densities. In this paper, we focus on overcoming this drawback of VAT algorithms by incorporating kernel methods, and also propose a novel adaptive cluster extraction strategy, named CER, to effectively identify the local clusters from the RDI. We examine their effects on an improved VAT method (iVAT), and systematically evaluate the clustering performance on 18 synthetic and real-world datasets. The experimental results reveal that the recently proposed data-dependent dissimilarity measure, namely, the Isolation kernel, helps to significantly improve the RDI image for easy cluster identification. Furthermore, the proposed cluster extraction method, CER, outperforms other existing methods on most of the datasets in terms of a series of dissimilarity measures.