bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract IA13: Use of administrative and electronic health records to identify cancer recurrences
Authors: Li Christopher I. 
Published: June 2022

Abstract
There are approximately 16 million cancer survivors in the United States, and outcomes of major concern for these survivors are their risks of developing a cancer recurrence, a second primary cancer, and dying of cancer. While cancer registries routinely collect data on second cancers and mortality, they do not ascertain data on recurrences. Gold-standard data on recurrences currently relies on review of medical records, which is costly, time consuming, and does not include events that occur after the review takes place. Extracting data from administrative and electronic health records provides an opportunity to ascertain information on recurrences in real time. We are using two approaches to address this issue that leverage gold-standard data on recurrences we have ascertained through one of our large population-based studies of breast cancer. The first involves the development and implementation of an algorithm for breast cancer recurrences using medical claims data, and the second applies machine learning and artificial intelligence to text in electronic health records. Methods and progress related to these two approaches will be presented.
Citation Format: Christopher I. Li. Use of administrative and electronic health records to identify cancer recurrences [abstract]. In: Proceedings of the AACR Special Conference on Modernizing Population Sciences in the Digital Age; 2019 Feb 19-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(9 Suppl):Abstract nr IA13.
Abstract IA25: Early progress on the All of Us Research Program
Authors: Denny Joshua C. 
Published: June 2022

Abstract
The US Precision Medicine Initiative All of Us Research Program seeks to engage at least 1 million diverse individuals across the US. To achieve this goal, the All of Us Research Program will recruit participants via health care provider organizations (including regional medical centers, federally qualified health centers, and Veterans Affairs Medical Centers) as well as through “direct volunteer” enrollment sites at fast-access convenience provider networks. All of Us will collect EHR records, participant-provided information, biospecimens, mobile and sensor data, and other data sources to provide a robust data sets for individuals. They will also be recontactable, based on user preferences, for possible subsequent studies and trials. Importantly, participants will have access to their information in All of Us. All of Us was launched May 6, 2018 and has now accrued over 95,000 individuals, with more than 160,000 having initially signed up. The ultimate goals for All of Us include enabling research that can lead to accurate diagnoses and redefinition of disease, more rational disease-prevention strategies, better treatment selection, and the discovery of novel therapies.
Citation Format: Joshua C. Denny. Early progress on the All of Us Research Program [abstract]. In: Proceedings of the AACR Special Conference on Modernizing Population Sciences in the Digital Age; 2019 Feb 19-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(9 Suppl):Abstract nr IA25.
Exploring Health Care Providers' Experiences of Providing Collaborative Palliative Care for Patients With Advanced Heart Failure At Home: A Qualitative Study
Authors: Graham Cassandra , Schonnop Rebecca , Killackey Tieghan , Kavalieratos Dio , Bush Shirley H. , Steinberg Leah , Mak Susanna , Quinn Kieran , Isenberg Sarina R. 
Published: June 2022

Background
The HeartFull Collaborative is a regionally organized model of care which involves specialist palliative care and cardiology health care providers (HCPs) in a collaborative, home‐based palliative care approach for patients with advanced heart failure (AHF). We evaluated HCP perspectives of barriers and facilitators to providing coordinated palliative care for patients with AHF at home.

Methods and Results
We conducted a qualitative study with 17 HCPs (11 palliative care and 6 cardiology) who were involved in the HeartFull Collaborative from April 2013 to March 2020. Individual, semi‐structured interviews were held with each practitioner from November 2019 to March 2020. We used an interpretivist and inductive thematic analysis approach. We identified facilitators at 2 levels: (1) individual HCP level (on‐going professional education to expand competency) and (2) interpersonal level (shared care between specialties, effective communication within the care team). Ongoing barriers were identified at 2 levels: (1) individual HCP level (e.g. apprehension of cardiology practitioners to introduce palliative care) and (2) system level (e.g. lack of availability of personal support worker hours).

Conclusions
Our results suggest that a collaborative shared model of care delivery between palliative care and cardiology improves knowledge exchange, collaboration and communication between specialties, and leads to more comprehensive patient care. Addressing ongoing barriers will help improve care delivery. Findings emphasize the acceptability of the program from a provider perspective, which is encouraging for future implementation. Further research is needed to improve prognostication, assess patient and caregiver perspectives regarding this model of care, and assess the economic feasibility and impact of this model of care.
Prior Antibiotic Exposure Is Associated With Reoperation After Elective Non-colorectal Surgery
Authors: Guidry Christopher A. , Medvecz Andrew J. , Adams Raeanna C. , Dennis Bradley M. , Eastham Shannon C. , Guillamondegui Oscar D. , Gunter Oliver L. , Peetz Allan B. , Thompson Callie M. , Gondek Stephen P. , Nunez Timothy C. , Sawyer Robert G. , May Addison K. , Patel Mayur B. 
Published: June 2022

Background Recent antibiotic exposure has previously been associated with poor outcomes following elective surgery. The purpose of this study is to evaluate the impact of prior recent antibiotic exposure in a multicenter cohort of Veterans Affairs patients undergoing elective non-colorectal surgery. Methods This is a retrospective cohort study of the Veterans Affairs Surgical Quality Improvement Program, including elective, non-cardiovascular, non-colorectal surgery from 2013 to 2017. Outpatient antibiotic exposure within 90 days prior to surgery was identified from the Veterans Affairs outpatient pharmacy database and matched with each case. Primary outcomes included serious complication, any complication, any infection, or surgical site infection. Secondary outcomes included 30-day mortality, length of stay, and Clostridioides difficile infection. Results Of 21,112 eligible patients, 2885 (13.7%) were exposed to antibiotics within 90 days prior to surgery with a duration of 7 (IQR: 5-10) days and prescribed 42 (IQR: 21-64) days prior to surgical intervention. Compared to non-exposed patients, exposed patients had higher unadjusted complication rates, increased length of stay, and rates of return to the operating. Exposure was independently associated with return to the operating room (OR: 1.39; 99% CI: 1.05-1.84). Conclusions Among Veterans, recent antibiotic exposure within 90 days of elective surgery was associated with a 39% increase in the odds of return to the operating room. Further work is needed to evaluate the effects of antibiotic exposure and dysbiosis on surgical outcomes.
Clinical Significance of Right Ventricle Echocardiographic Patterns in Critically-Ill COVID–Related Acute Respiratory Distress Syndrome “On Behalf of Protecting the Right Ventricle Network (PRORVnet)”
Authors: Lazzeri Chiara , Bonizzoli Manuela , Batacchi Stefano , Cianchi Giovanni , Chiostri Marco , Socci Filippo , Peris Adriano 
Published: June 2022

We assessed whether right ventricle (RV) alterations and their development may have clinical significance in critically-ill Coronavirus Disease (COVID) patients, as detected by serial echocardiograms during Intensive Care Unit (ICU) course. This observational single center study included 98 consecutive patients with COVID-related acute respiratory distress syndrome (ARDS). Three subgroups were considered: RV Dysfunction (Dys) on admission (10/98, 10%), developed RV Dys (17/98, 17%), and no RV Dys (71/98, 73%). Overall mortality at 3 months was 46.9%. The first subgroup was characterized by the highest need for Extracorporeal Membrane Oxygenation (ECMO) support ( P < .001) and a systemic inflammatory activation (as indicated by increased D-dimer), the second one by the lowest PaO2/FiO2 (P/F). At multivariate regression analysis, age and Sequential Organ Failure Assessment score were independent predictors for mortality. Different RV echo patterns were observed in critically ill patients presenting with COVID-related ARDS during ICU stay. RV Dys on admission was characterized by a high inflammatory activation while patients who developed RV Dys during ICU stay showed lowest P/F. Both these two subgroups identify patients with a severe COVID disease which in a high percentage of cases was unresponsive to standard treatment and required the use of ECMO.
Hydrophilicity and flux properties improvement of high performance polysulfone membranes via sulfonation and blending with Poly(lactic acid)
Authors: Tasci Reyhan O , Kaya Mehmet A , Celebi Mithat 
Published: June 2022

To achieve increased flow and reduce fouling, polymeric membranes can be functionalized with hydrophilic groups such as sulfone, amines, and others. This research has aimed at the sulfonation of Polysulfone (PSU) with various agents and at varying substitution degrees to change its hydrophobic character. PSU was also blended with Poly(lactic acid) (PLA), which is a more hydrophilic polymer. The phase inversion method was used to make PSU, PLA, sulfonated PSU, and PSU/PLA blend-based membranes. Sulfonation degrees of sulfonated PSU membranes were assessed using FT-IR, mechanical characteristics of membranes were determined, and thermal properties of membranes were clarified using DSC and TGA techniques. Hydrophilic natures and membrane alterations were investigated, as well as contact angle and water uptake measures. Among three distinct sulfonation agents (trimethylsilyl chlorosulfonate (TMSCS), sulfuric acid, and chlorosulfonic acid) employed to produce a 20% sulfonation degree of polysulfone, TMSCS was chosen as having the highest sulfonation efficiency (91.5%). With increasing sulfonation degree, a drop in molecular weight was seen in all sulfonated polysulfone samples. The mechanical strength values of polysulfone after sulfonation with TMSCS rose from 35.23 MPa to 63.35 MPa, while the contact angle value decreased from 85.58° to 71°. The contact angle value reduced from 85.58° to 64.68° while the mechanical strength of the PSU and PSU/PLA (50:50) blend increased from 35.23 MPa to 39.3 MPa. Membranes were also tested for pure water flux, hydrostability, and biostability. In terms of application requirements, it was determined that sulfonated PSU-based membranes manufactured with TMSCS with a 20% sulfonation degree and PSU/PLA blend-based membranes with a 50:50 (w:w) ratio have the optimum compositions with high flux quantities.
Evaluating of the effect of the cavitation-vortex interaction on the energy conversion in a two-stage LNG cryogenic submerged pump
Authors: Wang Cong , Zhang Yongxue , Yuan Zhiyi , Liu Zhigang 
Published: June 2022

The quantitative investigation on the unsteady interaction of the thermodynamic cavitation-vortex dynamics has been conducted via the developed entropy production diagnostic model in a two-stage liquefied natural gas cryogenic submerged pump. A thermodynamic cavitation modeling framework and Liutex method are applied to capture the characteristics of the formation, development and collapse of the cavities and vortex. It is found that the increasing flow rate and temperature both intensify the thermodynamic effect of cavitation. As the increase of flow rate, the thermodynamic effect suppresses the growth of cavities, thus raising the maximum temperature drop by 0.65 K at NPSH3% and 0.87 K at NPSH5% with the same temperature. Massive bubbles collapse causes the twist, deformation and breakdown of U-type vortex at the interface, which directly leads to the significant increase of interface entropy production rate in heat transfer entropy production rate (HTEPR). As the increase of temperature, the thermodynamic effect both shortens the cavity size and development period under the same flow rate. The strong shear and rotation regions drive upstream and the pressure rebounds rapidly downstream that weakens the backflow. The shrinkage of upstream cavity and the accelerated collapse of small-scale cloud cavity reduce the HTEPR and viscous flow entropy production rate
Moral distress in clinical research nurses
Authors: Showalter Brandi L , Malecha Ann , Cesario Sandra , Clutter Paula 
Published: June 2022

Background: Clinical research nurses experience unique challenges in the context of their role that can lead to conflict and moral distress. Although examined in many areas, moral distress has not been studied in clinical research nurses. Research aim: The aim of this study was to examine moral distress in clinical research nurses and the relationship between moral distress scores and demographic characteristics of clinical research nurses. Research design: This was a descriptive quantitative study to measure moral distress in clinical research nurses using the Measure of Moral Distress – Healthcare Professionals (MMD-HP) administered electronically. Demographic data were also collected. Participants and research context: Registered nurses working in the clinical research nurse role ( N = 322) were recruited through use of social media, emails, digital flyers, and snowball recruitment. Data was analyzed using SPSS. Pearson’s correlation, independent t-test, and one-way ANOVA were performed to explore differences among the demographic variables. Ethical considerations: This study was approved by the Institutional Review Board at Texas Woman’s University. A consent statement was included, and completion of the questionnaire was construed as consent. Findings/results: Analysis revealed a mean overall moral distress score of 79.58 (SD = 64.27) and median of 67, with a range of 0–354. Moral distress scores were negatively correlated with clinical research nurse age ( r = 0-.156, p < 0.05). Reliability of the MMD-HP was demonstrated with a Cronbach’s alpha of 0.93. Conclusions: The findings demonstrate that clinical research nurses do experience moral distress and revealed a wide range of scores. Further research is necessary to determine potential patient impact due to moral distress and to develop processes to minimize moral distress in the clinical research setting. This study was conducted during the COVID-19 pandemic, and the digital recruitment methods proved effective in recruiting a wide range of clinical research nurses, both nationally and internationally.
A multi-center retrospective comparative study of third generation Ceramic-on- Ceramic total hip arthroplasty in patients younger than 45 years with or without the sandwich liner: A ten-year minimum
Authors: He Bangjian , Li Xigong , Dong Rui , Tong Peijian , Sun Junying 
Published: June 2022

Background Ceramic-on-ceramic couplings are attractive alternative bearing surfaces that have been reported to eliminate or reduce problems related to polyethylene wear debris. However, the material in THA still remains one of the major concerns about the risk of fracture, due to its brittleness. Objective The present study aims at reporting the fracture rate of a series of ceramic-on-ceramic THAs with use of the sandwich liner combined with a ceramic femoral head, and attempt to detect the relative risk factors, possible cause and assesse the medium-term clinical results. Methods We retrospectively evaluated 282 patients (300 hips) with use of the sandwich liner ceramic-on-ceramic THA between 2001 and 2009 at three-centers. Patient assessment was based on demographic factors, including age, weight, gender and body-mass index. All patients were evaluated clinically and radio-graphically or computed tomography in consideration of dislocation, osteolysis, periprosthetic fracture, infection, loosening and implant fracture. Results five ceramic sandwich liners fracture (1.7%) were observed at an average of 7.3 years follow-up. These factors were irrelevant to the ceramic liner fracture, including age ( p = 0.205), weight ( p = 0.241), gender ( p = 0.553), body-mass index ( p = 0.736), inclination ( p = 0.727), and anteversion ( p = 0.606). The overall survival was 91.4% at 12 years with revision as the endpoint. Other complications included dislocation in two, perprosthetic fracture in two and osteolysis in eight hips. No hip had aseptic loosening of the implants was seen. Conclusions We found that the sandwich liner may be lead to a high rate of alumina fracture and osteolysis. We have discontinued the use of sandwich liner with THA since 2009.
Congenital Teratocarcinosarcoma With CTNNB1 Gene Mutation Presenting as an Ocular Mass
Authors: Almarzooqi Saeeda , Reyes-Múgica Miguel , Ali Bassam R , Habbal Aya , Asha Mohammad J , AlShamsi Eman T 
Published: June 2022

Teratocarcinosarcoma is an extremely rare malignancy of the nasal cavity and paranasal sinuses. It exhibits both sarcomatous and carcinomatous components. Less than 100 cases are reported. It presents in adults with only two reported cases in infancy. Here we present a case of 3-week-old female with antenatally detected ocular mass. MRI revealed an exophytic right ocular mass (10 × 7.0 × 7.0 cm) with intracranial extension. The tumor consisted of malignant glands and mesenchymal elements of undifferentiated blastema-like cells and immature neuroepithelium. After an initial diagnosis and treatment for a Wilms tumor protocol, the mass showed no response. A second opinion rendered a diagnosis of sinonasal teratocarcinosarcoma. The patient underwent surgical resection and seven cycles of CNS ICE chemotherapy. A second debulking surgery revealed a very scant viable tumor with post-treatment changes. The patient is alive at 43 months on weekly vincristine maintenance. Molecular testing revealed a somatic CTNNB1 gene mutation. In conclusion, this is a rare and aggressive tumor which showed disease free survival beyond that reported in the literature with the appropriate use of multimodality therapy.
Radiographic and Cadaveric Analysis of Minimally Invasive Bunionectomy Osteotomy Position—“MIS Bunion Sweet Spot”
Authors: Patel Rikhil , Siddiqui Noman , Dreyer Mark A. , Lam Kevin , Ayyagari Vineela , Onica Alexandru 
Published: June 2022

Minimally invasive surgery (MIS) is a growing technique that favors faster recovery and cosmetic results. We propose a recommended osteotomy position or “MIS Sweet Spot” to make the procedure more reproducible and lessen the learning curve to improve outcomes. A total of 211 patients from 3 surgeons between 2 different study centers were included in a retrospective radiograph measurement analysis and a cadaveric dissection to confirm the safety of nearby anatomical structures. An average distance of 2.2 cm proximal from the first metatarsophalangeal joint was found as the “Sweet Spot” to perform the transverse osteotomy. At this distance, neurovascular and tendinous structures were unharmed and the osteotomy remained extracapsular. Furthermore, an average of 10.7° of intermetatarsal angle reduction and a reduction of tibial sesamoid position of 3 points were achieved. A predictable and measurable distance for osteotomy placement will help to provide more confidence in producing the bunionectomy osteotomy with the specialized tools used in MIS and can help to reduce operative time and improve results. Level of Clinical Evidence (LOCE): 3
Comparison of susceptibility-weighted angiography (SWAN) and T2 gradient-echo sequences for the detection of acute cerebral venous thrombosis
Authors: Boukobza Monique , Guinebert Sylvain , Laissy Jean-Pierre 
Published: June 2022

Objectives To assess the diagnostic accuracy and lesion conspicuity of susceptibility-weighted angiography (SWAN) and T2* for the clot detection in acute cerebral venous thrombosis (CVT) by comparison with contrast-enhanced MR venography. Methods Venous thrombi detection and conspicuity were assessed by two readers for 18 venous segments on both T2*, SWAN source images, 2D SWAN reformats matching with T2*, and 3D SWAN images (SWAN-MinIP). Images obtained with the three reading techniques were systematically scored and compared to CE MRV findings, in a blinded fashion, per patient and per segment, and compared to each other. Results In 30 patients, 137 thrombosed venous segments were evaluated. The sensitivity of T2*, SWAN source images, 2D SWAN, and SWAN MinIP were, respectively, of 89.3%/82.1%, 82.1%, and 82.1% for dural sinus thrombosis and of 100%/100%/100%/96.6% for cortical venous thrombosis. There were significant differences in thrombus detection between T2* and SWAN: T2* versus SWAN source images and 2D SWAN ( p = 0.04) and versus SWAN MinIP ( p = 0.03). There were no significant differences between the three modalities of SWAN images. T2* was more sensitive than all SWAN images for both sigmoid sinus thrombosis and intracranial internal jugular vein thrombosis ( p = 0.04). Inter-observer agreement was slightly superior with T2* ( p < 0.05). Conclusion In this small cohort, SWAN sequence at 3T did not yield additional value for thrombus detection in acute CVT compared to T2*. This study highlights SWAN’s greatest weakness both for diagnostic accuracy and lesion conspicuity compared to T2* for acute venous clot detection near the skull base.