bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of underweight in people with severe mental illness: Systematic review and meta‐analysis
Authors: Khan Bilal Ahmad , Khalid Humaira , Siddiqi Najma , Aslam Faiza , Ayesha Rubab , Afzal Medhia , Rajan Sukanya , Appuhamy Kavindu , Koly Kamrun Nahar , Bryant Maria , Holt Richard I. G. , Zavala Gerardo A. 
Published: December 2022

AbstractPeople with severe mental illness (SMI) have a higher prevalence of obesity as compared with the general population, however, there is mixed evidence about the prevalence of underweight. Thus, the aim of this study is to determine the pooled prevalence of underweight in people with SMI and its association with socio‐demographic factors; and to compare the prevalence of underweight between SMI and the general population. MEDLINE, PsycINFO, and EMBASE databases were searched to identify observational studies assessing the prevalence of underweight in adults with SMI (schizophrenia, major depressive disorder with psychotic features, and bipolar disorders). Screening, data extraction, and risk of bias assessments were performed independently by two co‐authors, with disagreements resolved by consensus. Random effect estimates for the pooled prevalence of underweight and the pooled odds of underweight in people with SMI compared with the general population were calculated. Subgroup analyses were conducted for the type of SMI, setting, antipsychotic medication, region of the world, World Bank country income classification, data collection, and sex. Forty estimates from 22 countries were included. The pooled prevalence of underweight in people with SMI was 3.8% (95% confidence interval [CI] = 2.9–5.0). People with SMI were less likely to be underweight than the general population (odds ratio [OR] 0.65; 95% CI = 0.4–1.0). The pooled prevalence of underweight in SMI in South Asia was 7.5% (95% CI = 5.8–14.1) followed by Europe and Central Asia at 5.2% (95% CI = 3.2–8.1) and North America at 1.8% (95% CI = 1.2–2.6). People with SMI have lower odds of being underweight compared to the general population. People with schizophrenia had the highest prevalence of underweight compared to other types of SMI. Japan and South Asia have the highest prevalence of underweight in people with SMI.
DANMEL: A manually curated reference database for analyzing mobile genetic elements associated with bacterial drug resistance
Authors: Wang Peng , Jiang Xiaoyuan , Mu Kai , Jing Ying , Yin Zhe , Cui Yujun , Li Cuidan , Luo Xinhua , Chen Fangzhou , Yu Ting , Zhu Zhichen , Sun Yansong , Chen Fei , Zhou Dongsheng 
Published: December 2022

Impact statementWe have developed a manually curated online reference database, DANMEL (http://124.239.252.254/danmel/), that addresses the lack of accurate dissection and annotation of the genetic structures of mobile genetic elements (MGEs) with genes for drug resistance. DANMEL contains accurately annotated and genetically dissected reference MGEs covering 5 categories and 135 subcategories/subfamilies of MGEs. Further, DANMEL provides a detailed guide on how to precisely annotate MGEs. DANMEL also provides SEARCH/BLAST functions to facilitate finding reference MGEs. Overall, DANMEL will aid researchers to conduct in‐depth genetic analysis of sequenced bacterial MGEs with drug‐resistance genes and further facilitate a better understanding of bacterial MGEs associated with drug resistance at a genomic level.
Functional and structural markers of peripheral microvascular autonomic neuropathy
Authors: Rasmussen Thorsten K. , Karlsson Páll , Finnerup Nanna B. , Jensen Troels S. , Nyengaard Jens R. , Terkelsen Astrid J. 
Published: December 2022

AbstractIntroduction/AimsAutonomic dysfunction is a common complication of small‐fiber neuropathy (SFN). In this study we aimed to assess the applicability of autonomic microvascular indices as a potential marker for SFN assessment.MethodsFifteen patients with confirmed SFN (idiopathic neuropathy [n = 10], chemotherapy‐induced peripheral neuropathy [n = 2], impaired glucose tolerance [n = 1], hereditary transthyretin amyloidosis (hATTR) [n = 1], pulmonary sarcoidosis [n = 1]) and 15 matched control subjects underwent assessment of vascular skin responses assessed through laser Doppler flowmetry and evaluation of microvascular vessel and nerve density in skin biopsies. All participants underwent peripheral autonomic evaluation by quantitative sudomotor axon reflex testing (QSART).ResultsWe found no significant differences in vascular skin responses, or in any microvascular skin biopsy markers, when comparing SFN with control subjects. We found no correlation between vascular skin responses and skin biopsy indices. We saw no significant difference in any microvascular indices when comparing subjects with and without impaired sudomotor function.DiscussionOur findings suggest markers of peripheral microvascular innervation and function are not associated with the diagnosis of SFN. Furthermore, we saw no association between microvascular markers and sudomotor function, suggesting that these are independent and unrelated components of the autonomic nervous system.
On numerical study of constrained coupled shape optimization problems based on a new shape derivative method
Authors: Boulkhemair Abdesslam , Chakib Abdelkrim , Sadik Azeddine 
Published: December 2022

AbstractIn this article, we deal with a numerical method for the approximation of a class of coupled shape optimization problems, which consist in minimizing an appropriate general volume cost functional subjected to coupled boundary value problems by means of a Neumann boundary transmission condition. We show the existence of the shape derivative of the cost functional and express it by means of support functions, using a new formula of shape derivative on a family of convex domains. This allows us to avoid the disadvantages related to the classical shape derivative method using vectors field. Then the numerical discretization is performed using the dual reciprocity boundary element method in order to avert the remeshing task required for the finite element method. Finally, we give some numerical results, based on the gradient method, showing the efficiency of the proposed approach.
An elusive ghost: Searching for the Eagle Owl (Bubo bubo) in the past of Britain
Authors: Albarella Umberto , Higham Tom , McLean Alistair 
Published: December 2022

AbstractThe Eagle Owl (Bubo bubo) is currently absent as a regular breeder in Britain and its status as a native species has been debated. Its occurrence in the Pleistocene of Britain is sparse but uncontroversial, whereas its Holocene presence rests on very few ambiguous findings. Of these, a specimen from Demen's Dale (Derbyshire) originally attributed to the Mesolithic period is the most important. A re‐evaluation of this bone (tarsometatarsus) is presented in this paper. Although its identification as an Eagle Owl is confirmed, radiocarbon dating suggests that the bird rather lived in the Late Pleistocene. On the basis of the current evidence, there are no Holocene remains of the Eagle Owl in the archaeological and fossil record of Britain and the native status of this species remains unconfirmed.
Why did the chicken cross the Wallace Line? Archeological evidence suggests human‐mediated dispersal of Gallus to Flores first occurred at least ~2.25 ka cal. BP
Authors: Meijer Hanneke J. M. , Walker Samuel J. , Sutikna Thomas , Wahyu Saptomo E. , Tocheri Matthew W. 
Published: December 2022

AbstractDomesticated chickens (Gallus gallus domesticus) are a dominant part of the global human diet. Although the early domestication history of this species remains disputed, Mainland Southeast Asia (MSEA) is assumed to have been the initial domestication center. The eastward spread of chickens into Island Southeast Asia (ISEA) and the Pacific is typically attributed to human‐mediated dispersals. Chicken remains are relatively common at Pacific Neolithic sites but are extremely rare in the archaeological records of MSEA and ISEA. Therefore, the exact routes and timing of the human‐mediated spread of chickens from their native range in MSEA into the Pacific remain questions of interest. Here, we present the earliest evidence of Gallus on the Indonesian island of Flores at Liang Bua. This site has yielded an extensive stratigraphic sequence that spans from ~190,000 calendar years (ka) ago until the present and includes dense accumulations of faunal remains. Twelve bones from the cave's Holocene deposits have been identified as Gallus. The oldest remains, a right and left coracoid, were each directly dated to ~2,250 calibrated radiocarbon years before present (ka cal. BP), whereas the youngest Gallus elements are ~0.3 ka old. Although wild Green Junglefowl (Gallus varius) and Red Junglefowl (Gallus gallus) are found on Flores today, the absence of either of these species in deposits at Liang Bua older than ~2.5 ka as well as the size and shape of the oldest coracoids suggests that these remains likely represent domesticated G. gallus. This is the first evidence for domesticated chickens in the Neolithic of Flores and the first directly dated Gallus remains in Wallacea. The absence of chickens in the fossil record of ISEA suggests that Red Junglefowl (and perhaps Green Junglefowl also) reached Wallacea via human‐mediated dispersal(s) at least ~2.25 ka cal. BP.
Higher walkability associated with increased physical activity and reduced obesity among United States adults
Authors: Wang Monica L. , Narcisse Marie‐Rachelle , McElfish Pearl A. 
Published: December 2022

AbstractObjectiveThis study examined associations among perceived neighborhood walkability, physical activity (PA), and obesity among United States adults.MethodsData from the 2020 National Health Interview Survey were analyzed. Walkability was assessed using a summative scale and was categorized as low, medium, or high. PA was categorized as insufficient (0‐149 min/wk) or sufficient (150+ min/wk). Multivariable regressions estimated an association between obesity and BMI and PA/walkability. Mediation analysis was used to partition contribution of PA as a mediator. Effect modification by race and ethnicity in the association between walkability and BMI was explored.ResultsThe sample included N = 31,568 adults. Compared with those in low‐walkability neighborhoods, participants in high‐walkability neighborhoods had increased odds of sufficient PA (odds ratio [OR] = 1.48; 95% CI: 1.30‐1.69) and decreased obesity odds (OR = 0.76; 95% CI: 0.66‐0.87). PA partially mediated the association between walkability and BMI (23.4%; 95% CI: 14.6%‐62.7%). The association between walkability and BMI was modified by race and ethnicity (F[5,567] = 2.75; p = 0.018). Among White, Black, Hispanic, and Asian adults, BMI decreased with increasing walkability; among American Indian/Alaska Native and multiracial/other adults, BMI increased with increasing walkability.ConclusionsThe findings highlight the importance of investing in the built environment to improve perceptions of walkability and promote PA and healthy weight, as well as developing interventions to target racial and ethnic disparities in these outcomes.
Dose‐dependent effects of esketamine on brain activity in awake mice: A BOLD phMRI study
Authors: Kawazoe Kyrsten , McGlynn Ryan , Felix Wilder , Sevilla Raquel , Liao Siyang , Kulkarni Praveen , Ferris Craig F. 
Published: December 2022

AbstractPharmacological magnetic resonance imaging (phMRI) is a noninvasive method used to evaluate neural circuitry involved in the behavioral effects of drugs like ketamine, independent of their specific biochemical mechanism. The study was designed to evaluate the immediate effect of esketamine, the S‐isomer of (±) ketamine on brain activity in awake mice using blood oxygenation level dependent (BOLD) imaging. It was hypothesized the prefrontal cortex, hippocampus, and brain areas associated with reward and motivation would show a dose‐dependent increase in brain activity. Mice were given vehicle, 1.0, 3.3, or 10 mg/kg esketamine I.P. and imaged for 10 min post‐treatment. Data for each treatment were registered to a 3D MRI mouse brain atlas providing site‐specific information on 134 different brain areas. There was a global change in brain activity for both positive and negative BOLD signal affecting over 50 brain areas. Many areas showed a dose‐dependent decrease in positive BOLD signal, for example, cortex, hippocampus, and thalamus. The most common profile when comparing the three doses was a U‐shape with the 3.3 dose having the lowest change in signal. At 1.0 mg/kg there was a significant increase in positive BOLD in forebrain areas and hippocampus. The anticipated dose‐dependent increase in BOLD was not realized; instead, the lowest dose of 1.0 mg/kg had the greatest effect on brain activity. The prefrontal cortex and hippocampus were significantly activated corroborating previous imaging studies in humans and animals. The unexpected sensitivity to the 1.0 mg/kg dose of esketamine could be explained by imaging in fully awake mice without the confound of anesthesia and/or its greater affinity for the N‐methyl‐d‐aspartate receptor (NMDAR) receptor than (±) ketamine.
Fabrication of Graphdiyne/Graphene Composite Microsphere with Wrinkled Surface via Ultrasonic Spray Compounding and its Microwave Absorption Properties
Authors: Ling Mengyun , Wu Fei , Liu Pei , Zhang Qiuyu , Zhang Baoliang 
Published: December 2022

AbstractAdvanced carbon materials are constantly being used in the field of microwave absorption. Herein, in order to enrich the variety and expand the application fields of graphdiyne (GDY), the wrinkled graphene (RGO) nanosheet coated and embedded with GDY porous microspheres (RGO/GDY) are prepared by GDY synthesis, ultrasonic spray, and pyrolysis. The study finds that RGO and GDY have effective synergistic effects. The suitable pores and composition, conductive network formed by overlapping 0D and 2D materials, special surface and internal morphology design, and high‐temperature activation process make RGO/GDY exhibit excellent impedance matching and attenuation capabilities. Under the best amount of GDY (20 mg), the particle sizes of the microspheres (≈6 µm), and filler content (27.5%), the minimum reflection loss (RLmin) is −58 dB@8.3 GHz, and the corresponding matching thickness is 2.7 mm. The effective absorption bandwidth is 4.3 GHz as the thickness is 1.9 mm. By adjusting the thickness, the absorber can completely absorb microwaves of all the C, X, and Ku bands. The microwave absorbing mechanisms are elucidated. GDY materials are first applied to the field of microwave absorption, enhancing the absorption performance of RGO/GDY. It provides a new way to manufacture electromagnetic wave absorbers with satisfactory performance.
Activating Single‐Atom Ni Site via First‐Shell Si Modulation Boosts Oxygen Reduction Reaction
Authors: Wang Fangqing , Li Ying , Zhang Rui , Liu Hui , Zhang Yangyang , Zheng Xuerong , Zhang Jun , Chen Cong , Zheng Shijian , Xin Huolin L. 
Published: December 2022

AbstractAtomically dispersed nitrogen‐coordinated 3d transition‐metal site on carbon support (M‐NC) are promising alternatives to Pt group metal‐based catalysts toward oxygen reduction reaction (ORR). However, despite the excellent activities of most of M‐NC catalysts, such as Fe‐NC, Co‐NC et al., their durability is far from satisfactory due to Fenton reaction. Herein, this work reports a novel Si‐doped Ni‐NC catalyst (Ni‐SiNC) that possesses high activity and excellent stability. X‐ray absorption fine structure and aberration‐corrected transmission electron microscopy uncover that the single‐atom Ni site is coordinated with one Si atom and three N atoms, constructing Ni‐Si1N3 moiety. The Ni‐SiNC catalyst exhibits a half‐wave potential (E1/2) of 0.866 V versus RHE, with a distinguished long‐term durability in alkaline media of only 10 mV negative shift in E1/2 after 35 000 cycles, which is also validated in Zn‐air battery. Density functional theory calculations reveal that the Ni‐Si1N3 moiety facilitates ORR kinetics through optimizing the adsorption of intermediates.
Encapsulating Ni Nanoparticles into Interlayers of Nitrogen‐Doped Nb2CTx MXene to Boost Hydrogen Evolution Reaction in Acid
Authors: Huang Jingle , Feng Min , Peng Yang , Huang Churong , Yue Xin , Huang Shaoming 
Published: December 2022

AbstractDesign and development of low‐cost and highly efficient non‐precious metal electrocatalysts for hydrogen evolution reaction (HER) in an acidic medium are key issues to realize the commercialization of proton exchange membrane water electrolyzers. Ni is regarded as an ideal alternative to substitute Pt for HER based on the similar electronic structure and low price as well. However, low intrinsic activity and poor stability in acid restrict its practical applications. Herein, a new approach is reported to encapsulate Ni nanoparticles (NPs) into interlayer edges of N‐doped Nb2CTx MXene (Ni NPs@N‐Nb2CTx) by an electrochemical process. The as‐prepared Ni NPs@N‐Nb2CTx possesses Pt‐like onset potentials and can reach 500 mA cm−2 at overpotentials of only 383 mV, which is much higher than that of N‐Nb2CTx supported Ni NPs synthesized by a wet‐chemical method (w‐ Ni NPs/N‐Nb2CTx). Furthermore, it shows high durability toward HER with a large current density of 300 mA cm−2 for 24 h because of the encapsulated structure against corrosion, oxidation as well as aggregation of Ni NPs in an acidic medium. Detailed structural characterization and density functional theory calculations reveal that the stronger interaction boosts the HER.
Multimodal‐Synergistic‐Modulation Neuromorphic Imaging Systems for Simulating Dry Eye Imaging
Authors: Han Xu , Zhao Xiaoli , Zeng Tao , Yang Yahan , Yu Hongyan , Zhang Cong , Wang Bin , Liu Xiaoqian , Zhang Tao , Sun Jing , Li Xinyuan , Zhao Tuo , Zhang Mingxin , Ni Yanping , Tong Yanhong , Tang Qingxin , Liu Yichun 
Published: December 2022

AbstractInspired by human eyes, the neuromorphic visual system employs a highly efficient imaging and recognition process, which offers tremendous advantages in image acquisition, data pre‐processing, and dynamic storage. However, it is still an enormous challenge to simultaneously simulate the structure, function, and environmental adaptive behavior of the human eye based on one device. Here, a multimodal‐synergistic‐modulation neuromorphic imaging system based on ultraflexible synaptic transistors is successfully presented and firstly simulates the dry eye imaging behavior at the device level. Moreover, important functions of the human visual system in relation to optoelectronic synaptic plasticity, image erasure and enhancement, real‐time preprocessing, and dynamic storage are simulated by versatile devices. This work not only simplifies the complexity of traditional neuromorphic visual systems, but also plays a positive role in the publicity of biomedical eye care.
Confine, Defect, and Interface Manipulation of Fe3Se4/3D Graphene Targeting Fast and Stable Potassium‐Ion Storage
Authors: Liu Yu , Wan Qi , Gong Juan , Liu Zhiwei , Tao Gang , Zhao Jie , Chen Le , Li Wenshu , Wei Xijun , Ni Ling , Song Yingze 
Published: December 2022

AbstractThe fast electrochemical kinetics behavior and long cycling life have been the goals in developing anode materials for potassium ion batteries (PIBs). On account of high electron conductivity and theoretical capacity, transition metal selenides have been deemed as one of the promising anode materials for PIBs. Herein, a systematic structural manipulation strategy, pertaining to the confine of Fe3Se4 particles by 3D graphene and the dual phosphorus (P) doping to the Fe3Se4/3DG (DP‐Fe3Se4/3DG), has been proposed to fulfill the efficient potassium‐ion (K‐ion) evolution kinetics and thus boost the K‐ion storage performance. The theoretical calculation results demonstrate that the well‐designed dual P doping interface can effectively promote K‐ion adsorption behavior and provide a low energy barrier for K‐ion diffusion. The insertion‐conversion and adsorption mechanism for multi potassium storage behavior in DP‐Fe3Se4/3DG composite has been also deciphered by combining the in situ/ex situ X‐ray diffraction and operando Raman spectra evidences. As expected, the DP‐Fe3Se4/3DG anode exhibits superior rate capability (120.2 mA h g−1 at 10 A g−1) and outstanding cycling performance (157.9 mA h g−1 after 1000 cycles at 5 A g−1).
Multi‐Unit Needleless Electrospinning for One‐Step Construction of 3D Waterproof MF‐PVA Nanofibrous Membranes as High‐Performance Air Filters
Authors: Yan Guilong , Yang Zihao , Li Jiayi , Li Han , Wei Jiabing , Shi Letian , Li Zhenyu , Chen Jingyu , Wang Li , Wu Yuanpeng 
Published: December 2022

AbstractThe airborne particulate matter (PM) seriously threatens people's health. Personal protective equipment with electrospun nanofibers is an effective method to make people away from air pollutants. Herein, 3D waterproof melamine‐formaldehyde polyvinyl alcohol (MF‐PVA) nanofibrous membranes are fabricated by a one‐step method combining multi‐unit needleless electrospinning and a thermal treatment device in a line. 3D nanofibrous structures can be controlled by adjusting the solution concentration of each unit. The PVA nanofibrous membranes become waterproof after cross‐linking with MF resin in the following thermal treatment device. The optimized MF‐PVA nanofibrous membrane shows excellent air filtration performance (97.3% for PM0.3, 100% for PM1.0, and 100% for PM2.5) and low air resistance (76 Pa). These 3D waterproof MF‐PVA nanofibrous membranes exhibit ultra‐stable performance in various practical environments.
Creeping fat formation and interaction with intestinal disease in Crohn's disease
Authors: Yin Yi , Xie Ying , Ge Wei , Li Yi 
Published: December 2022

AbstractCreeping fat (CrF), also known as fat wrapping, is a significant disease characteristic of Crohn's disease (CD). The transmural inflammation impairs intestinal integrity and facilitates bacteria translocation, aggravating immune response. CrF is a rich source of pro‐inflammatory and pro‐fibrotic cytokines with complex immune microenvironment. The inflamed and stricturing intestine is often wrapped by CrF, and CrF is associated with greater severity of CD. The large amount of innate and adaptive immune cells as well as adipocytes in CrF promote fibrosis in the affected intestine by secreting large amount of pro‐fibrotic cytokines, adipokines, growth factors and fatty acids. CrF is a potential therapeutic target for CD treatment and a promising bio‐marker for predicting response to drug therapy. This review aims to summarize and update the clinical manifestation and application of CrF and the underlying molecular mechanism involved in the pathogenesis of intestinal inflammation and fibrosis in CD.