bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnitude and Predictors of In-Hospital Stroke Mortality in Ethiopia: A Systematic Review and Meta-Analysis
Authors: Tareke Amare Abera , Abate Masrie Getnet , Alem Addis , Alamneh Yoseph Merkeb , Alamneh Alehegn Aderaw , Deml Yikeber Argachew , Shiferaw Mulu , Kassahun Woldeteklehaymanot , Teym Abraham 
Published: May 2022

Introduction. Stroke is the second leading cause of mortality worldwide, accounting for approximately 5.5 million deaths each year. Due to demographic and health changes, the epidemiology of stroke is shifting from industrialized to low- and middle-income nations. Ethiopia is a developing country with a population that reflects this shift. Therefore, this systematic review and meta-analysis are aimed at evaluating the extent of in-hospital mortality of both ischemic and hemorrhagic stroke in Ethiopia and determining relevant factors associated with the mortality. Methods. Observational studies published as of July 15, 2020, that reported the magnitude, predictors, and causes of in-hospital mortality of stroke were systematically and comprehensively retrieved using the PRISMA 2020 criteria from databases such as PubMed/MEDLINE, Science Direct, and Google Scholar. The review papers were chosen based on the study methodology (facility-based observational), the study area (Ethiopia), the study population (adult patients with stroke), the outcome (in-hospital mortality), and the fact that they were published in English. Result. A total of 3709 patients with stroke were included in this systematic review and meta-analysis, which included 19 publications. In-hospital mortality was 14.03 percent on average in the studies, with reports ranging from 6.04 percent to 37.37 percent. Patients with hemorrhagic type stroke, admission Glasgow Coma Scale less than or equal to 12, impaired mental status, National Institutes of Health Stroke Scale stroke level greater than 13, prolonged hospital stay, any incontinence, pneumonia, and/or swallowing trouble had an increased risk of death after stroke. Conclusion. The magnitude of in-hospital mortality of patients with stroke in Ethiopia is high. The assessment of the level of consciousness is vital for clinical management and as an indicator of prognosis. Patients with unfavorable prognostic signs, such as entry Glasgow Coma Scale, National Institutes of Health Stroke Scale

stroke

level
>
13

, hemorrhagic stroke, pneumonia, incontinence, and dysphagia, should be given priority.
A novel efficient adaptive-neuro fuzzy inference system control based smart grid to enhance power quality
Authors: Sekhar Dharamalla Chandra , Rama Rao Pokanati Veera Venkata , Kiranmayi Rachamadugu 
Published: May 2022

<span>A novel adaptive-neuro fuzzy inference system (ANFIS) control algorithm-based smart grid to solve power quality issues is investigated in this paper. To improve the steady-state and transient response of the solar-wind and grid integrated system proposed ANFIS controller works very well. Fuzzy maximum power point tracking (MPPT) algorithm-based DC-DC converters are utilized to extract maximum power from solar. A permanent magnet synchronous generator (PMSG) is employed to get maximum power from wind. To maximize both power generations, back-to-back voltage source converters (VSC) are operated with an intelligent ANFIS controller. Optimal power converters are adopted this proposed methodology and improved the overall performance of the system to an acceptable limit. The simulation results are obtained for a different mode of smart grid and non-linear fault conditions and the proven proposed control algorithm works well.</span>
Design, modeling and simulation of perturb and observe maximum power point tracking for a photovoltaic water pumping system
Authors: Hilali Abdelilah , Mardoude Yahya , Ben Akka Youssef , El Alami Hassan , Rahali Abderrafii 
Published: May 2022

<span>Maximum power point tracking (MPPT)</span><span> is considered one of the important factors in minimizing the installation costs and improving the efficiency of any photovoltaic water pumping system. The MPPT controller is specifically used to extract the maximum available power from the </span><span>photovoltaic (PV) array. The maximum power can be achieved by using a specific algorithm. This work aims to raise awareness among farmers about the energy benefits available in the region of Meknes in Morocco, the economic gain and the environmental impact applied to the solar pumping system so that it can be generalized. To obtain the maximum power at each moment, a direct current (DC) water pump (SQF 0-6-2) powered by the solar panels (REC_330NP) through a buck converter was adapted. In addition, this study illustrates the theory of operation of the perturb and observe (P&amp;O) algorithm and simulates the evaluation of this algorithm under different operating conditions (temperature and solar irradiation), and showed the advantages of this system that can operate at the optimal power regardless of disturbances.</span>
A Study of Evaluation Influence in Two Child Protection Programs
Authors: Herbert James Leslie 
Published: May 2022

Evaluation influence is a reconceptualization of evaluation use that reflects the broad and diffuse impacts an evaluation can have on social programs and policies. This way of thinking about impact provides an opportunity to investigate how and why evaluations influence social programs and policy. Twenty participants (practitioners and managers) from two child protection programs evaluated in the previous 24 months were interviewed about the influence of these evaluations, which was complemented with the collection of internal documents about changes to the programs. A qualitative case study analysis of evaluation influence was conducted using the interviews and documents to investigate the influence of two evaluations at different stages in the dissemination process. The participants identified that the evaluations appeared to have significant high-level policy level influence; however, limited examples of influence on practices in the programs were identified. There was some suggestion that the evaluations had increased practitioner interest in working with and participating in program evaluations. The findings suggest the importance of developmental evaluation approaches and practitioner engagement in evaluation to improve the influence and adoption of new knowledge from the evaluation of social programs.
Prospective clinical study testing the efficacy and safety of a new formula to increase the precision of oxygen therapy in the initiation phase of cardiopulmonary bypass
Authors: Turra Jan , Riesterer David , Eisner Christoph , Wenzel Folker , Möbius Andreas , Karck Matthias , Arif Rawa , Lichtenstern Christoph , Fischer Dania 
Published: May 2022

Introduction During cardiopulmonary bypass (CPB), supranormal concentrations of oxygen are routinely administered with the intention to prevent cellular hypoxia. However, hyperoxemia may have adverse effects on patient outcome. Oxygen settings are based on the perfusionist’s individual work experience rather than profound recommendations and studies analyzing the effect of oxygen levels are in need of methodological improvement. We aimed to advance perfusion technique by developing and clinically applying a formula for tailored oxygen therapy in CPB. Methods A formula to precalculate the oxygenator setting before CPB was developed. The newly-derived formula was then evaluated in a prospective, single-center pilot study to test whether a predefined arterial partial oxygen pressure (PaO2) of 150–250 mmHg could be reached. 80 patients were enrolled in the study between April and September 2021. Results The mean oxygen fraction calculated for the setting of the gas blender was 52% ±0,12. The mean PaO2 after initiation of the CPB was 193 ± 99 mmHg (min-max: 61-484, median 163 mmHg). 38.75% of the values were in the desired PaO2 corridor of 150 to 250 mmHg. 8.75% of all PaO2 values were below <79.9 mmHg, 31.25% between 80 and 149.9 mmHg, 38.75% between 150 and 249.9 mmHg and 21.25%>250 mmHg. Conclusions Conceptually, perfusion technique should be goal-directed, guided by objective parameters and formulas. Although the optimal CPB oxygenation target remains unknown, it is nevertheless important to develop strategies to tailor oxygen therapy to aid in creating evidence as to what level of oxygen is best for patients during CPB. The formula we derived needs further adjustments to increase results in the target range.
Procollagen C-protease enhancer protein is a prognostic factor for glioma and promotes glioma development by regulating multiple tumor-related pathways and immune microenvironment
Authors: Zhao Zijun , Zhao Jiahui , Wang Zairan , Wu Yue , Zhang Zhanzhan , Song Zihan , Miao Jihao , Liu Boheng , Zhang Shiyang , Sun Boyu , Zhao Zongmao 
Published: May 2022

Objectives Glioma is a common type of brain tumor with high incidence and mortality rates. Procollagen C-protease enhancer protein (PCOLCE) has been shown to regulate tumor growth and metastasis in several cancers. However, the role of PCOLCE in glioma is unknown. This study aims to assess the association between PCOLCE and prognosis of glioma, and investigated the potential mechanisms. Methods The prognostic value of PCOLCE was determined using data from nine publicly available glioma cohorts. We also investigated the relationship between PCOLCE and glioma immune microenvironment and predicted response to immunotherapy based on the expression levels of PCOLCE. The potential roles of PCOLCE in glioma were also explored and validated in cell experiment. Results Survival analysis suggested that high-PCOLCE expression was associated with poor prognosis in glioma. Upregulation of PCOLCE enhanced an immune suppressive microenvironment in glioma by regulating immunocyte infiltration and Cancer-Immunity Cycle. Cox and ROC analysis revealed that PCOLCE was a prognostic factor for glioma and could be used to predict survival of the patients. Patients with low-PCOLCE expression were more likely to respond to Immunotherapy with ICI (immune checkpoint inhibitor) and survive longer. Enrichment analysis showed that PCOLCE was associated with multiple tumor-related pathways. Finally, we demonstrated that the knockdown of PCOLCE inhibited glioma development by regulating cell cycle and promoting apoptosis in in vitro experiments. Conclusion PCOLCE promotes glioma progression by regulating multiple tumor-related pathways and immune microenvironment and can be used as a prognostic factor for glioma.
Incidence, Risk Factors, and Prognosis of Bloodstream Infections in COVID-19 Patients in Intensive Care: A Single-Center Observational Study
Authors: Kurt Ahmet Furkan , Mete Bilgul , Urkmez Seval , Demirkiran Oktay , Dumanli Guleren Yartas , Bozbay Suha , Dilken Olcay , Karaali Ridvan , Balkan Ilker Inanç , Saltoğlu Nese , Dikmen Yalim , Tabak Fehmi , Aygun Gokhan 
Published: May 2022

Background Critically ill COVID-19 patients are prone to bloodstream infections (BSIs). Aim To evaluate the incidence, risk factors, and prognosis of BSIs developing in COVID-19 patients in the intensive care unit (ICU). Methods Patients staying at least 48 h in ICU from 22 March 2020 to 25 May 2021 were included. Demographic, clinical, and laboratory data were analyzed. Results The median age of the sample (n  =  470) was 66 years (IQR 56.0-76.0), and 64% were male. The three most common comorbidities were hypertension (49.8%), diabetes mellitus (32.8%), and coronary artery disease (25.7%). Further, 252 BSI episodes developed in 179 patients, and the BSI incidence rate was 50.2 (95% CI 44.3-56.7) per 1000 patient-days. The source of BSI is central venous catheter in 42.5% and lower respiratory tract in 38.9% of the episodes. Acinetobacter baumannii (40%) and carbapenem-resistant Klebsiella pneumoniae (21%) were the most common pathogens. CRP levels were lower in patients receiving tocilizumab. Multivariable analysis revealed that continuous renal replacement therapy, extracorporeal membrane oxygenation, and treatment with a combination of methylprednisolone and tocilizumab were independent risk factors for BSI. The estimated cumulative risk of developing first BSI episode was 50% after 6 days and 100% after 25 days. Of the 179 patients, 149 (83.2%) died, and a statistically significant difference ( p < 0.001) was found in the survival distribution in favor of the group without BSI. Conclusion BSI is a common complication in COVID-19 patients followed in the ICU, and it can lead to mortality. Failure in infection control measures, intensive immunosuppressive treatments, and invasive interventions are among the main factors leading to BSIs.
Cognitive Limitations Among Middle Eastern and North African Immigrants
Authors: Kindratt Tiffany B. , Dallo Florence J. , Zahodne Laura B. , Ajrouch Kristine J. 
Published: May 2022

Objectives: To estimate and compare the prevalence of cognitive limitations among Middle Eastern and North African (MENA) immigrants compared to US- and foreign-born non-Hispanic Whites from Europe (including Russia/former USSR) and examine differences after controlling for risk factors. Methods: Cross-sectional data using linked 2000-2017 National Health Interview Survey and 2001–2018 Medical Expenditure Panel Survey data (ages >=65 years, n = 24,827) were analyzed. Results: The prevalence of cognitive limitations was 17.3% among MENA immigrants compared to 9.6% and 13.6% among US- and foreign-born non-Hispanic Whites from Europe. MENA immigrants had higher odds (OR = 1.88; 95% CI = 1.06–3.34) of reporting a cognitive limitation than US-born non-Hispanic Whites after controlling for age, sex, education, hearing loss, hypertension, depression, social isolation, and diabetes. Discussion: To further examine cognitive health among the MENA aging population, policy changes are needed to identify this group that is often absent from research because of their federal classification as non-Hispanic Whites.
Upper limb functional testing in athletes: A Delphi study
Authors: Tooth Camille , Schwartz Cédric , Ann Cools , Croisier Jean-Louis , Gofflot Amandine , Stephen Bornheim , Forthomme Bénédicte 
Published: May 2022

Background Functional testing has recently become more and more popular to assess athletes, both for injury prevention, as well as in an objective of performance. However, the relationship between the results of these tests and performances (or injuries) or their interpretation remains unclear. Objective The aim of this study is to explore the usefulness, the characteristics, and the interpretation of the most frequently used upper-limb functional test. Methods Twenty-two experts with an excellent knowledge of upper limb functional tests and an expertise in sports medicine and/or sports training of at least 5 years were recruited. They answered to qualitative and quantitative questions about functional testing trough structured questionnaires (online). Results Four rounds were needed to reach a consensus about the usefulness as well as the characteristics of each test. Different sports-specific batteries of tests were also suggested by the experts and reached consensus. However, concerning the interpretation of the test, a consensus was only found for half of the tests considered. Conclusion The current study summarizes the characteristics and the usefulness of the most popular upper-limb functional tests. However, the interpretation of some tests will have to be further explored since no consensus was found for them.
A systematic review of outpatient billing practices
Authors: Burks Kristie , Shields Jessie , Evans Joseph , Plumley Jodi , Gerlach Jarrett , Flesher Susan 
Published: May 2022

Objectives: Healthcare coding and billing are an important aspect of practice management that directly impacts the financial stability of a health care practice. To financially sustain or grow a medical practice, it is imperative that resident and faculty physicians have knowledge and skills for accurate billing in every patient encounter. Methods: A systematic review was conducted to identify recently published studies that report on improvements in medical coding and billing accuracy, clinical documentation, and reimbursement rate. A search of three databases yielded a total of 5754 records. After screening, 41 records were sought for retrieval and a total of 18 records were obtained for review. Results: Following a thorough review of literature, the most common reasons for inaccurate or inappropriate billing were a lack of formal education within residency curriculum, inadequate clinical documentation supporting level of billing, and lack of a feedback system aimed to correct billing errors. Conclusion: A formal education curriculum implemented in training could enhance knowledge and application of accurate billing and coding and further benefit practice longevity. The purpose of this systematic review is to apply knowledge gained to the development and implementation of a quality improvement study intended to improve accuracy of coding and billing within an academic pediatric outpatient center.
A unifying hypothesis for PNMZL and PTFL: morphological variants with a common molecular profile
Authors: Salmeron-Villalobos Julia , Egan Caoimhe , Borgmann Vanessa , Müller Inga , Gonzalez-Farre Blanca , Ramis-Zaldivar Joan Enric , Nann Dominik , Balagué Olga , López-Guerra Mónica , Colomer Dolors , Oschlies Ilske , Klapper Wolfram , Glaser Selina , Ko Young Hyeh , Bonzheim Irina , Siebert Reiner , Fend Falko , Pittaluga Stefania , Campo Elias , Salaverria Itziar , Jaffe Elaine S. , Quintanilla-Martinez Leticia 
Published: May 2022

Abstract
Pediatric nodal marginal zone lymphoma (PNMZL) is an uncommon B-cell neoplasm affecting mainly male children and young adults. This indolent lymphoma has distinct characteristics that differ from those of conventional nodal marginal zone lymphoma (NMZL). Clinically, it exhibits overlapping features with pediatric-type follicular lymphoma (PTFL). To explore the differences between PNMZL and adult NMZL and its relationship to PTFL, a series of 45 PNMZL cases were characterized morphologically and genetically by using an integrated approach; this approach included whole-exome sequencing in a subset of cases, targeted next-generation sequencing, and copy number and DNA methylation arrays. Fourteen cases (31%) were diagnosed as PNMZL, and 31 cases (69%) showed overlapping histologic features between PNMZL and PTFL, including a minor component of residual serpiginous germinal centers reminiscent of PTFL and a dominant interfollicular B-cell component characteristic of PNMZL. All cases displayed low genomic complexity (1.2 alterations per case) with recurrent 1p36/TNFRSF14 copy number–neutral loss of heterozygosity alterations and copy number loss (11%). Similar to PTFL, the most frequently mutated genes in PNMZL were MAP2K1 (42%), TNFRSF14 (36%), and IRF8 (34%). DNA methylation analysis revealed no major differences between PTFL and PNMZL. Genetic alterations typically seen in conventional NMZL were absent in PNMZL. In summary, overlapping clinical, morphologic, and molecular findings (including low genetic complexity; recurrent alterations in MAP2K1, TNFRSF14, and IRF8; and similar methylation profiles) indicate that PNMZL and PTFL are likely part of a single disease with variation in the histologic spectrum. The term “pediatric-type follicular lymphoma with and without marginal zone differentiation” is suggested.
Serum proteomics unveil characteristic protein diagnostic biomarkers and signaling pathways in patients with esophageal squamous cell carcinoma
Authors: Liu Wenhu , Wang Qiang , Chang Jinxia , Bhetuwal Anup , Bhattarai Nisha , Zhang Fan , Tang Jiancai 
Published: May 2022

Abstract
Background
Esophageal squamous cell carcinoma (ESCC) is a common digestive tract malignant tumor with high incidence and dismal prognosis worldwide. However, the reliable biomarkers for clinical diagnosis and the underlying signaling pathways insights of ESCC are not unequivocally understood yet. The serum proteome may provide valuable clues for the early diagnosis of ESCC and the discovery of novel molecular insights.

Methods
In the current study, an optimized proteomics approach was employed to discover novel serum-based biomarkers for ESCC, and unveil abnormal signal pathways. Gene ontology (GO) enrichment analysis was done by Gene Set Enrichment Analysis (GSEA) and Metascape database, respectively. Pathway analysis was accomplished by GeneCards database. The correlation coefficient was assessed using Pearson and distance correlation analyses. Prioritized candidates were further verified in two independent validation sets by enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry (IHC) staining.

Results
A total of 633 non-redundant proteins were identified in the serum of patients with ESCC, of which 59 and 10 proteins displayed a more than 1.5-fold increase or decrease compared with healthy controls. Verification was performed for six candidate biomarkers, including S100A8/A9, SAA1, ENO1, TPI1 and PGAM1. Receiver operating characteristics (ROC) curve plotting showed the high diagnostic sensitivity and specificity of these six protein molecules as a biomarker panel: the area under characteristic curve (AUC) is up to 0.945. Differentially expressed proteins were subjected to functional enrichment analysis, which revealed the dysregulation of signaling pathways mainly involved in glycolysis, TLR4, HIF-1α, Cori cycle, TCA cycle, folate metabolism, and platelet degranulation. The latter finding was all the more noteworthy as a strong positive correlation was discovered between activated glycolysis and TLR4 pathways and unfavorable clinicopathological TNM stages in ESCC.

Conclusions
Our findings propose a potential serum biomarker panel for the early detection and diagnosis of ESCC, which could potentially broaden insights into the characteristics of ESCC from the proteomic perspective.
Biological variation in the serum and urine kidney injury markers of a healthy population measured within 24 hours
Authors: Kong Li-Rui , Wei Fei , He Da-Hai , Zhou Chao-Qiong , Li Hong-chuan , Wu Feng , Luo Yu , Luo Jian-wei , Xie Qian-rong , Peng Hai , Zhang Yan 
Published: May 2022

Abstract
Background and aims
To explore the biological variation (BV) of kidney injury markers in serum and urine of healthy subjects within 24 hours to assist with interpretation of future studies using these biomarkers in the context of known BV.

Materials and methods
Serum and urine samples were collected every 4 hours (0, 4, 8, 12, 16 and 20 hours) from 31 healthy subjects within 24 hours and serum creatinine (s-Crea), serum β2-microglobin (s-β2MG), serum cystatin C (s-CYSC), serum neutrophil gelatinase-associated lipoprotein (s-NGAL), urine creatinine (u-Crea), urine β2-microglobin (u-β2MG), urine cystatin C (u-CYSC), urine neutrophil gelatinase-associated lipoprotein (u-NGAL) were measured. Outlier and variance homogeneity analyses were performed, followed by CV-ANOVA analysis on trend-corrected data (if relevant), and analytical (CVA), within-subject (CVI), and between-subject (CVG) biological variation were calculated.

Results
The concentration of kidney injury markers in male was higher than that in female, except for u-CYSC and u-NGAL. There were no significant difference in serum and urine kidney injury markers concentration at different time points. Serum CVI was lower than urine CVI, serum CVG was higher than CVI, and urine CVG was lower than CVI. The individual index (II) of serum kidney injury markers was less than 0.6, while the II of urinary kidney injury markers was more than 1.0.

Conclusions
This study provides new short-term BV data for kidney injury markers in healthy subjects within 24 hours, which are of great significance in explaining other AKI / CKD studies.