bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Waste Plastic Char as Adsorbent for Removal of Arsenic and COD from Aqueous Solution
Authors: DUTTA NEELANJAN , Gupta Anirban 
Published: January 2022

Abstract
In present study, the solid char derived from the pyrolysis of waste high-density polyethylene (HDPE) and polypropylene (PP) was tested for removal (adsorption) of inorganic arsenic (As5+) and organic matters (COD) from water and wastewater, respectively. It was observed that the solid char could remove 60% of arsenic (+5) at a dose of 4 gm/L for a contact time of 30 min and the COD removal was 50% at a dose of 4 gm/L with a contact time of 25 min. In both cases the adsorption data was found to fit better with Langmuir model. The adsorption capacity of mixed plastic char for As5+ was observed to be in the range of 1.45 – 1.75 mg/gm and in the range of 60.625-67.9 mg/gm for COD. Proximate and ultimate analysis indicated that the pyrolytic char had a large quantity of volatile matter (46.50-48.0%), carbon (41.3–84.7%), and a small amount of moisture (1.2-2.5%). The calorific value and density of plastic char were found to be in the range of 13.50-17.50 MJ/kg and 1.55 - 1.60 gm/m3. FTIR spectra of mixed HDPE and PP waste pyrolytic oil showed the presence of mostly alkanes and alkenes. It was found that with the increase of pyrolysis temperature, the pore size of solid char increased. The XRD pattern of the plastic chars obtained in this study showed sharp diffraction crystalline peaks. The plastic char can be used for further research for removal of other contaminants from aqueous solution.
Exceptional points controlling oscillation death in coupled spintronic nano-oscillators
Authors: Wittrock Steffen , Perna Salvatore , Lebrun Romain , Dutra Roberta , Ferreira Ricardo , Bortolotti Paolo , Serpico Claudio , Cros Vincent 
Published: January 2022

Abstract
The emergence of exceptional points (EPs) in the parameter space of a (2D) eigenvalue problem is studied in a general sense in mathematical physics. In coupled systems, it gives rise to unique physical phenomena upon which novel approaches for the development of seminal types of highly sensitive sensors shall leverage their fascinating properties. Here, we demonstrate at room temperature the emergence of EPs in coupled spintronic nanoscale oscillators, coming along with the observation of amplitude death of self-oscillations and other complex dynamics. The main experimental features are properly described by the linearized theory of coupled system dynamics we develop. Interestingly, these spintronic nanoscale oscillators are deployment-ready in different applicational technologies, such as field, current or rotation sensors, radiofrequeny and wireless devices and, more recently, novel neuromorphic hardware solutions. Their unique and versatile properties, notably their large nonlinear behavior open up unprecedented perspectives in experiments as well as in theory on the physics of exceptional points. Furthermore, the exploitation of EPs in spintronics devises a new paradigm for ultrasensitive nanoscale sensors and the implementation of complex dynamics in the framework of non-conventional computing.
Analysis on the detection rate of Giardia lamblia in children of Sichuan province of China
Authors: Hu Zhengqiang , Zhong Yonglin , Li Jie , Li Yunxia 
Published: January 2022

Abstract
Objective
To investigate the detection rates of Giardia lamblia in children of Sichuan province and analyze the susceptible population and the cause of infection.
Methods
The routine fecal examination of a total of 11575 cases were done by normal wet smear microscopy, and the suspected cases were stained with iodine in outpatient children of West China Second University Hospital, Sichuan University from September 1st, 2020 to August 31th, 2021.
Results
In the stools of 11,515 outpatient children, 11 cases of cysts or trophozoites of G. lamblia were detected, among which 9 cases were from ethnic minority patients and 2 case were from Han patients. The G. lamblia detection rate of Han patients was 0.019%, while that of ethnic minority patients was 0.968%, between which there was a statistically significant difference (P<0.05).
Conclusions
The detection rate of G. lamblia in minority patients was higher than that in Han patients. To reduce the spread and epidemic of giardiasis, the epidemic prevention in minority areas should be strengthened and the good hygienic habits of children should be cultivated.
Stability Analysis and Flutter Suppression of Ultrasonic Elliptical Vibration Milling of Ti-6Al-4V Alloy
Authors: Zhang Yuemin , Wang Xiaobo , Niu Ying , Zhao Bo 
Published: January 2022

Abstract
Ti-6Al-4V alloy is typical aircraft materials to be difficult machined. Ultrasonic elliptical vibration-assisted milling has been proved to greatly enhance machining performance. In ultrasonic elliptical vibration milling(UEVM), the cutting edge moves in 3D space, reducing extrusion friction between the flank and machined surface, and playing an important role in high precision-efficient manufacturing of difficult-to-cut materials. This paper focused on the stability analysis and flutter supression of ultrasonic elliptical vibration milling of Ti-6Al-4V alloy. There are separated and unseparated types of ultrasonic elliptical vibration milling systems, which stability is analyzed in this study by simulating their tool tip motion paths. The essence of the tip and workpiece at high-frequency separation is revealed through analysis of cutter tooth path in UEVM. Next, the coordinate method is used to set up the window function to facilitate the derivation of true instantaneous chip thickness. The dynamic model of UEVM is established to study the system stability and plot its stability prediction lobes diagrams. The effect of machining parameters on the system stability is assessed and discussed in detail. The prediction results show that the stability region and axial depth of cut grow with the increase of feed rate per tooth and decrease of ultrasonic frequency. Among the six groups of ultrasonic amplitude parameters studied, the optimal system's stability corresponds to the ultrasonic amplitudes of 5 and 3μm in the x-and y-directions, respectively. Finally, stability tests of UEVM are performed, which results well match the numerical simulation predictions. This implies that the proposed window function is adequate, the theoretical model is valid, and the predicted stability curve is feasible and reliable.
Visualizing Omicron: COVID-19 Deaths vs. Cases Over Time
Authors: Arnaout Ramy , Arnaout Rima 
Published: January 2022

Abstract
For most of the COVID-19 pandemic, the daily focus has been on the number of cases, and secondarily, deaths. The most recent wave is caused by the omicron variant, first identified at the end of 2021 and the dominant variant through the first part of 2022. South Africa, one of the first countries to experience and report data regarding omicron, reported far fewer deaths, even as the number of reported cases rapidly eclipsed previous peaks. However, as more countries report on omicron, there remains uncertainty as to how it compares to prior waves. To more readily visualize the dynamics of cases and deaths, it is natural to plot deaths per million against cases per million. Unlike the time-series plots of cases or deaths that have become daily features of news outlets during the pandemic, which have time as the x-axis, in a plot of deaths vs. cases, time is implicit, and is indicated in relation to the starting point. Here we present and briefly examine such plots from a number of countries and from the world as a whole, illustrating how they summarize features of the pandemic in ways that are harder to extract from time series. These plots suggest that in most places, the omicron wave is very different from those that came before. Code for generating these plots for any country is provided on GitHub (https://github.com/rarnaout/Covidcycles).
Fluctuations of the planetary gravitational field and nonlinear interactions with matter – triggering earthquakes.
Authors: Nitsche Michael 
Published: January 2022

Abstract
AbstractThe orbits of the big planets are very stable during millions of years. In addition to this, there is another important circumstance: the orbits of the planets lie almost on the same level. They represent natural oscillators on a big scale. Such a rhythm or such duration of vibration is determined by the time period from conjunction to conjunction of two planets. These are relatively stable frequencies. A non-linear correlation function forms a good way of describing these processes. It can be shown that this correlation function can also be interpreted as a non-linear interaction of the planetary fluctuations of the gravitational field with material structures. The vibrations of the planetary gravitational field lead to higher vibrations, to higher harmonics, in material structures. The problems of the correlation function are the coefficients ak and the meaning of Hij. In my researches I restricted myself to the polar qualities which are associated with the concepts of "stability" and "instability". The change from stable to unstable conditions and vice versa, can be observed in the evolution of many complex systems. Statistical researches will be presented and show this non-linear influence.
A Facile Synthesis of CuBi2O4 Hierarchical Dumbbell-Shaped Nanorods Cluster: A Promising Photocatalyst for the Degradation of Caffeic Acid
Authors: Ashfaq Mohammad , Talreja Neetu , Chauhan Divya , Rodríguez Carlos Anibal , Mera Adriana Consuelo , Mangalaraja Ramalinga Viswanathan 
Published: January 2022

Abstract
The present study focuses on synthesizing Cu-bismuth oxide (CuBi2O4) based nanorods by using a simple co-precipitation method for the photocatalytic degradation of caffeic acid (CA). Incorporating Cu metal ions during the synthesis of CuBi2O4 nanorods might be advantageous to avoid aggregation and control the leach out of metal ions. The calculated bandgap values of ~ 1.04, 1.02, and 0.94 eV were observed for CuBi2O4 with different amounts of Cu 1.0, 0.50, and 0.25 g, respectively. Varying quantities of Cu metal ions easily tuned the bandgap value within the CuBi2O4 based nanorods. However, a further decrease in the bandgap value increased the recombination rate; less photocatalyst performance was observed. The Cu within the CuBi2O4 based nanorods changed the electronic properties as well as the antibacterial ability. Therefore, the synthesized CuBi2O4 based nanorods cluster might be a promising material for the photocatalytic degradation of CA.
[18F]DPA-714 PET Imaging for the Quantitative Evaluation of Early Spatiotemporal Changes of Neuroinflammation in Rat Brain Following Status Epilepticus
Authors: Kaneko Kenichi , Irie Satsuki , Mawatari Aya , Igesaka Ami , Hu Di , Nakaoka Takayoshi , Hayashinaka Emi , Wada Yasuhiro , Doi Hisashi , Watanabe Yasuyoshi , Cui Yilong 
Published: January 2022

Abstract
Background
Most antiepileptic drug therapies are symptomatic and adversely suppress normal brain function by nonspecific inhibition of neuronal activity. In recent times, growing evidence has suggested that neuroinflammation triggered by epileptic seizures might be involved in the pathogenesis of epilepsy. Although the potential effectiveness of anti-inflammatory treatment for curing epilepsy has been extensively discussed, the limited quantitative data regarding spatiotemporal characteristics of neuroinflammation after epileptic seizures makes it difficult to be realized. We quantitatively analyzed the spatiotemporal changes in neuroinflammation in the early phase after status epilepticus in rats, using translocator protein (TSPO) positron emission tomography (PET) imaging, which has been widely used for the quantitative evaluation of neuroinflammation in several animal models of CNS disease.
Methods
The second-generation TSPO PET probe, [18F]DPA-714, was used for brain-wide quantitative analysis of neuroinflammation in the brains of rats, when the status epilepticus was induced by subcutaneous injection of kainic acid (KA, 15 mg/kg) into those rats. A series of [18F]DPA-714 PET scans were performed at 1, 3, 7, and 15 days after status epilepticus, and the corresponding histological changes, including activation of microglia and astrocytes, were confirmed by immunohistochemistry.
Results
Apparent accumulation of [18F]DPA-714 was observed in several KA-induced epileptogenic regions, such as the amygdala, piriform cortex, ventral hippocampus, mediodorsal thalamus, and cortical regions 3 days after status epilepticus, and was reversibly displaced by unlabeled PK11195 (1 mg/kg). Consecutive [18F]DPA-714 PET scans revealed that accumulation of [18F]DPA-714 was focused in the KA-induced epileptogenic regions from 3 days after status epilepticus and was further maintained in the amygdala and piriform cortex until 7 days after status epilepticus. Immunohistochemical analysis revealed that activated microglia but not reactive astrocytes, were correlated with [18F]DPA-714 accumulation in the KA-induced epileptogenic regions for at least 1 week after status epilepticus.
Conclusions
These results indicate that the early spatiotemporal characteristics of neuroinflammation quantitatively evaluated by [18F]DPA-714 PET imaging provides valuable evidence for developing new anti-inflammatory therapies for epilepsy. The predominant activation of microglia around epileptogenic regions in the early phase after status epilepticus could be a crucial therapeutic target for curing epilepsy.
Edentulous ridge space closure after bone augmentation using different graft materials: A report of two cases
Authors: Lin Shih-Ying , Sun Teresa Chanting , Chou Chia-Hsuan , Hsu Li-Fang 
Published: January 2022

Abstract
Post-extraction alveolar ridge resorption is a common sequela when missing mandibular molar spaces are not managed in a timely fashion. The situation becomes more complicated in patients who seek orthodontic treatment if closure of the edentulous space is the major objective in order to avoid prosthetic rehabilitation. In the present article, two cases are reported, in which different bone augmentation graft materials were used and treatment duration and post-orthodontic alveolar ridge characteristics were compared. A regional acceleratory phenomenon after the grafting procedure facilitated uneventful orthodontic space closure. The status of the investing alveolar bone was compared using post-treatment cone-beam computed tomography. Both autogenous bone graft and allograft ridge augmentation procedures aided in successful molar protraction through the resorbed mandibular alveolar ridge, as well as preventing periodontal attachment loss.
Análise da viabilidade econômica, em condições de riscos, do sistema de confinamento utilizado para a terminação de bovinos no estado de São Paulo, Brasil
Authors: Rodrigues Queiroz Kaio Expedito , Damaceno dos Reis Janderson , Rozemberg Peixoto Simões André 
Published: January 2022

Objetivo: Avaliar a sensibilidade e a viabilidade econômica do sistema de confinamento utilizado para a engorda de bovinos tomando como referência uma propriedade localizada no norte do estado de São Paulo, Brasil.
Metodologia: Utilizou-se a abordagem multidimensional para avaliar a sensibilidade, o resultado econômico foi analisado através do fluxo de caixa sendo o valor presente líquido (VPL) o indicador de viabilidade, os riscos foram incorporados com a simulação de Monte Carlo para os preços de alimentação, aquisição e venda dos animais que foram as variáveis aleatórias discretas, já a medida de valor foi o VPL, calculado com a taxa mínima de atratividade de 7,55% ao semestre e as probabilidades foram estimadas pela frequência relativa.
Resultados: A probabilidade de o confinamento ser uma atividade atrativa economicamente foi de 30,2%, consequentemente o sistema foi inviável em 69,8%. No âmbito da sensibilidade, o confinamento foi mais vulnerável à oscilações no preço de venda, o aumento de 1% no valor do boi gordo gerou o acréscimo de 46% no VPL, sendo seguido pelo preço de reposição, o aumento de 1% no valor do boi magro levou a uma redução de 29% no VPL, e pelo preço da alimentação, o aumento de 1% no valor da tonelada de matéria seca diminuiu o VPL em 12%.
Contribuições do Estudo: Os resultados encontrados nesta pesquisa poderão subsidiar novas avaliações em amostras representativas, incorporar os estudos sobre essa temática e auxiliar os tomadores de decisão.
Antisense Agents against Antibiotic-resistant Bacteria
Authors: Kafil Hossein Samadi , Nezhadi Javad , Taghizadeh Sepehr , Khodadadi Ehsaneh , Yousefi Mehdi , Ganbarov Khudaverdi , Yousefi Bahman , Leylabadlo Hamed Ebrahimzadeh , Asgharzadeh Mohammad , Tanomand Asghar , Kazeminava Fahimeh 
Published: January 2022

Abstract:The dramatically increasing levels of antibiotic resistance are being seen worldwide and are a significant threat to public health. Antibiotic and drug resistance is seen in various bacterial species. Antibiotic resistance is associated with increased morbidity and mortality and increased treatment costs. Antisense-related technologies include oligonucleotides that interfere with gene transcription and expression; these oligonucleotides can help treat antibiotic-resistant bacteria. The important oligonucleotides include Peptide Nucleic Acids (PNAs), Phosphorodiamidate Morpholino Oligomers (PPMOs), and Locked Nucleic Acids (LNAs). Typically, the size of these structures (oligonucleotides) is 10 to 20 bases. PNAs, PPMOs, and LNAs are highlighted in this review as targets for genes that cause the gene to be destroyed and impede bacterial growth. These results open a new perspective for therapeutic intervention. Future studies need to examine different aspects of antisense agents, such as the safety, toxicity, and pharmacokinetic properties of antisense agents in clinical treatment.
An Updated Review on the Role of Single Nucleotide Polymorphisms in
COVID-19 Disease Severity: A Global Aspect
Authors: Lee Ping-Chin , Ng Jun Wei , Chong Eric Tzyy Jiann 
Published: January 2022

Abstract:
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syn-drome coronavirus 2 (SARS-CoV-2) and recently has become a serious global pandemic. Age, gender, and comorbidities are known to be common risk factors for severe COVID-19 but are not enough to fully explain the magnitude of their effect on the risk of severity of the disease. Single nucleotide polymorphisms (SNPs) in several genes have been reported as a genetic factor contrib-uting to COVID-19 severity. This comprehensive review focuses on the association between SNPs in four important genes and COVID-19 severity in a global aspect. We discuss a total of 39 SNPs in this review: five SNPs in the ABO gene, nine SNPs in the angiotensin-converting enzyme 2 (ACE2) gene, 19 SNPs in the transmembrane protease serine 2 (TMPRSS2) gene, and six SNPs in the toll-like receptor 7 (TLR7) gene. These SNPs data could assist in monitoring an individual’s risk of severe COVID-19 disease, and therefore personalized management and pharmaceutical treatment could be planned in COVID-19 patients.
Association of Circulating Levels of Hypoxia-Inducible Factor-1α
and miR-210 with Photosensitivity in Systemic Lupus
Erythematosus Patients
Authors: Gamal-Eldeen Amira M. , Fahmy Cinderella A. , Raafat Bassem M. , Althobaiti Fayez , Bassyouni Iman H. , Talaat Roba M. 
Published: January 2022

Background:
miR-210, a key hypoxamiR, regulates hypoxia and
inflammation-linked hypoxia. Systemic lupus erythematosus (SLE), a chronic
autoimmune disease, is responsible for many pathological disorders, including
photosensitivity.

Objective:
This study aimed to find the correlation between circulating miR-210/HIF-1α
levels and photosensitivity in SLE patients and other SLE-associated pathological
complications in a single-center case-control study.

Methods:
The study population comprised 104 SLE Egyptian patients with
photosensitivity, 32 SLE patients without photosensitivity, and 32 healthy subjects. SLE
activity was assessed for all patients using the SLE Disease Activity Index (SLEDAI).
Clinical complications/manifestations and hematological/serological analyses were
recorded. HIF-α concentration was investigated by ELISA, and miR-210 expression was
analyzed by qRT-PCR.

Results:
The results revealed that circulating miR-210 was significantly increased in the
SLE/photosensitivity group versus the SLE and control groups. The additional
occurrence of malar rash, oral ulcers, renal disorders, or hypertension resulted in a
higher expression of miR-210. SLEDAI activity status showed no effect on miR-210.
Erythrocyte sedimentation rate, white blood cells, hemoglobin, platelets, patient age, and
disease duration were positively correlated with circulatory miR-210. HIF-α concentration
was significantly induced in the SLE/photosensitivity group versus the SLE and control
groups. In SLE/photosensitivity, the presence of renal disorders and hypertension
resulted in the highest HIF-α concentrations. A strong positive correlation was recorded
between HIF-α concentration and circulatory miR-210 in SLE/photosensitivity patients (r
= 0.886).

Conclusion::
The dysregulation of circulating miR-210/HIF-1α levels in SLE/
photosensitivity patients is controlled by the presence of additional pathological
complications, and results suggest that the hypoxia pathway might interact positively
with the pathogenesis and disease progression of SLE.
Identification of AHSA1 as a Potential Therapeutic Target for Breast
Cancer: Bioinformatics Analysis and in vitro Studies
Authors: Zhao Hong , Lu Jin-Jian , Shi Wei , Qi Lu , You Xiong-Bin , Chen Yu-Chi , Xu Yu-Lian , Yu Wei-Bang , Huang Mu-Yang 
Published: January 2022

Background:
Shenling Baizhu Powder (SBP), a famous Traditional Chinese Medicine
(TCM) formulation, has been widely used in the adjuvant treatment of cancers, including breast
cancer. This study aims to identify potential new targets for breast cancer treatment based on the
network pharmacology of SBP.

Methods:
By analyzing the relationship between herbs and target proteins, potential targets of multiple
herbs in SBP were identified by network pharmacology analysis. Besides, by comparing the
data of breast cancer tissue with normal tissue, upregulated genes in two breast cancer expression
profiles were found. Thereafter, the expression level and prognosis of activator of heat shock protein
90 (HSP90) ATPase activity 1 (AHSA1) were further analyzed in breast cancer by bioinformatics
analysis, and the network module of AHSA1 binding protein was constructed. Furthermore, the
effect of knocking down AHSA1 on the proliferation, migration, and invasion of breast cancer
cells was verified by MTT, clone formation assay, and transwell assay.

Results:
Vascular endothelial growth factor A (VEGFA), intercellular adhesion molecule 1 (ICAM1),
chemokine (C-X-C motif) ligand 8 (CXCL8), AHSA1, and serpin family E member 1
(SERPINE1) were associated with multiple herbs in SBP. AHSA1 was remarkably upregulated in
breast cancer tissues and positively correlated with poor overall survival and disease metastasis-
free survival. Furthermore, knockdown of AHSA1 significantly inhibited the migration and invasion
in MCF-7 and MDA-MB-231 breast cancer cells but had no obvious effect on proliferation.
In addition, among the proteins that bind to AHSAl, the network composed of proteasome, chaperonin,
and heat shock proteins is closely connected, and these proteins are associated with poor prognosis
in a variety of cancers.

Conclusion:
AHSA1 is positively correlated with breast cancer progression and might act as a novel
therapeutic target for breast cancer.