bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peering into the young planetary system AB Pic
Authors: Palma-Bifani P. , Chauvin G. , Bonnefoy M. , Rojo P. M. , Petrus S. , Rodet L. , Langlois M. , Allard F. , Charnay B. , Desgrange C. , Homeier D. , Lagrange A.-M. , Beuzit J.-L. , Baudoz P. , Boccaletti A. , Chomez A. , Delorme P. , Desidera S. , Feldt M. , Ginski C. , Gratton R. , Maire A.-L. , Meyer M. , Samland M. , Snellen I. , Vigan A. , Zhang Y. 
Published: November 2022

Aims. We aim to revisit the formation pathway of AB Pic b, an imaged companion that straddles the exoplanet/brown-dwarf boundary. We based this study on a rich set of observations, which allows us to investigate its orbital and atmospheric properties.Methods. We composed a spectrum of AB Pic b by merging archival medium-resolution (~4000) VLT/SINFONI K band (1.96–2.45 µm) data with published spectra atJandHbands from SINFONI,Lpband from Magellan-AO/CLIO2, and photometric measurements from HST (visible) andSpitzer(mid-infrared). We modeled the spectrum with ForMoSA, following a forward-modeling approach based on two atmospheric models: ExoREM and BT-SETTL13. In parallel, we determined the orbital properties of AB Pic b fitting orbital solutions to astrometric measurements from NaCo (2003 and 2004) and SPHERE (2015).Results. The orbital solutions favor a semi-major axis of 190-50+200au on a highly inclined orbit (edge-on), but with a poorly constrained eccentricity. From the atmospheric modeling with Exo-REM, we derive an effective temperature of 1700 ± 50 K and surface gravity of 4.5 ± 0.3 dex, which are consistent with previous findings, and we report for the first time a c/o ratio of 0.58 ± 0.08, consistent with the value for the Sun. The posteriors are sensitive to the wavelength interval and the family of models used. Given the published rotation period of 2.1 h and our derivedυsin(i) of 73-27+11km s−1, we estimate for the first time the true obliquity of AB Pic b to be between 45 and 135 deg, indicating a rather significant misalignment between the spin and orbit orientations of the planet. Finally, the existence of a proper-motion anomaly between the HIPPARCOSandGaiaEarly Data Release 3 compared to our SPHERE detection limits and adapted radial velocity limits indicates the potential existence of a ~6MJupinner planet orbiting from 2 to 10 au (40–200 mas).Conclusions. The possible existence of an inner companion and the likely misalignment of the spin-axis orientation strongly favor a formation path by gravitational instability or core accretion within a protoplanetary disk at a smaller orbital radius followed by a dynamical interaction which scattered AB Pic b to its current location. Confirmation and characterization of this unseen inner exoplanet and access to a broader wavelength coverage and higher spectral resolution for the characterization of AB Picb will be essential for probing the uncertainties associated with the atmospheric and orbital parameters.
Impact of short-term pausing of oral corticosteroids on blood eosinophil count in patients with severe asthma
Authors: Biener Leonie , Milger Katrin , Suhling Hendrik , Korn Stephanie , Pizarro Carmen , Skowasch Dirk 
Published: November 2022

Abstract
Background The peripheral blood eosinophil count (BEC) is a well-established and easily accessible biomarker for asthma patients and crucial for the therapeutic decision regarding monoclonal antibody (mAB) therapy. Oral corticosteroid therapy frequently hinders the correct evaluation of BEC in patients with severe asthma, but a discontinuation of such therapy frequently comes along with severe side effects. Therefore, we examined the effect of a short 24-hour pause of OCS treatment on BEC in patients with severe asthma and followed-up whether patients with a then increased eosinophil count benefited from mAB-therapy, as expected.
Methods In this multicentre study we retrospectively included 24 patients with severe asthma and OCS therapy and determined their BEC count. Ten patients, where BEC count was obtained in the morning before taking medication (a de-facto 24-hour OCS pause), were assigned to group 1. Fourteen patients, where BEC was obtained after OCS tapering were assigned to group 2. Those who then received mAB treatment were followed up for treatment response (OCS dose, annual acute exacerbations, increase in forced expiratory volume in one second [FEV1] and asthma control test [ACT]) after ≥3 months.
Results We included 24 patients with a median age of 60.5 [IQR: 17.3] years. Regarding all baseline characteristics except FEV1 (l), both groups did not differ significantly.Among all 24 patients, after pausing OCS therapy for 2 [5.5] days the BEC increased significantly from 125.0/μl [125] to 300/μl [232.5] (p<0.001). In both individual groups BEC increased significantly as well (150 [123] to 325 [305], p=0.005 and 70 [150] to 280 [255], p<0.001), with no significant difference for increase (BEC +170/µl [205.0] vs. +195 [222.5], p=0.886). Of all 24 patients, 13 (54.2%) reached eosinophil levels ≥300/µl, while 12 of them had not exceeded this threshold before.Subsequently, 20 patients (83.3%) received mAB-therapy with 55.5% demonstrating a good treatment response within 6 [1.5] months. The response rate in patients with BEC count ≥300/µl was even higher (75.0%). There was no difference in the treatment response rate between group 1 and 2 (p=0.092).
Conclusion After just a short 24-hour pause of OCS therapy it was possible to demask a relevant eosinophilia in asthma patients, without risking severe side effects. In this manner, we enabled the possibility of achieving successful targeted mAB-therapy, according to the patient’s individual asthma phenotype.
In Vitro Fertilization and Adverse Pregnancy Outcomes in the Elective Single Embryo Transfer Era
Authors: Stairs Jocelyn , Hsieh Tina Y. J. , Rolnik Daniel L. 
Published: November 2022

Objective Our objective was to estimate the association between in vitro fertilization (IVF) pregnancy and adverse pregnancy outcomes during delivery hospital admission in a contemporary, nation-wide cohort of births in the United States.
Study Design This retrospective, population-based cohort study used the National Inpatient Sample database to identify patients discharged from the hospital following delivery from 2014 to 2019. IVF pregnancies were identified using the International Classification of Disease-Revision 9/10 codes. Crude and adjusted odds ratios of preterm birth and other clinically significant adverse pregnancy outcomes were evaluated using multivariable logistic regression models. Trends in preterm birth and multiple pregnancy were estimated over the study period. The contribution of multiple pregnancy to preterm birth in IVF pregnancy was estimated in a mediation analysis.
Results Among 4,451,667 delivery-related discharges, IVF pregnancies were associated with 3.25 times the odds of preterm birth (95% confidence interval [CI]: 3.05–3.46, p < 0.001) compared with non-IVF pregnancy deliveries. Odds of preterm birth in IVF pregnancy delivery discharges decreased over the study period (p-value for linear trend = 0.009). The proportion of multiple pregnancies decreased in IVF pregnancy delivery discharges but remained stable in non-IVF pregnancy deliveries. The proportion of the adjusted effect of IVF pregnancy on preterm birth mediated through multiple pregnancy was 67.6% (95% CI: 62.6–72.7%).
Conclusion While the odds of adverse pregnancy outcomes are increased compared with non-IVF pregnancies, the odds of preterm birth and multiple gestation have decreased among IVF pregnancies in the United States.
Key Points
Association between Maternal Serum Lipids and Intrapartum Oxytocin Requirements during Labor Induction and Augmentation
Authors: Frolova Antonina I. , Prifti Kevin K. , Raghuraman Nandini , Carter Ebony B. , England Sarah K. , Stout Molly J. 
Published: November 2022

Objective This study aimed to investigate the relationship between maternal serum lipid parameters and oxytocin requirements among women with term vaginal deliveries.
Study Design In this secondary analysis of a prospective cohort study, women who presented for delivery at ≥37 weeks' gestation and received oxytocin during their labor were included. Maternal serum was collected intrapartum. The cohort was stratified into two groups based on maximum oxytocin infusion dose during labor. Primary outcomes were maternal total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride levels. Generalized linear regression models were used to assess the association between lipid parameters and maximum oxytocin dose requirements while controlling for potential confounders. For secondary analyses, the cohort was stratified by HDL-C into two groups. Multivariable logistic regression was used to evaluate the relationship between low maternal HDL-C and additional intrapartum oxytocin parameters.
Results There were no differences in maternal total cholesterol, LDL-C, or triglyceride values between high and low maximum oxytocin groups. Median serum HDL-C was significantly lower among women in the high oxytocin group compared with those in the low oxytocin group (56 vs. 62 mg/dL, p < 0.01). For every 0.26 mg/dL lower HDL-C, women had 1 mU/min higher maximum oxytocin infusion dose during labor. Women with low serum HDL-C were also more likely to require maximum oxytocin doses above the 75th percentile (adjusted odds ratio [aOR]: 1.99, 95% confidence interval [CI]: 1.06–3.75) and above the 90th percentile (aOR: 2.47, 95% CI: 1.10–5.54). Among women undergoing induction of labor, low serum HDL-C was also associated with longer duration of oxytocin infusion (aOR: 2.07, 95% CI: 1.02–4.20).
Conclusion Low maternal HDL-C levels at term are associated with higher maximum oxytocin infusion doses among women undergoing labor induction or augmentation. Given the growing prevalence of metabolic syndrome in the United States and persistently high rates of cesarean delivery, HDL-C or its components may present a new target for predicting and improving labor outcomes.
Key Points
Genetic Predisposition of Both Waist Circumference and Hip Circumference Increased the Risk of Venous Thromboembolism
Authors: Wang Jiayu , Tan Jiangshan , Hua Lu , Sheng Qiping , Huang Xianwei , Liu Ping 
Published: November 2022

Background Obesity, especially abdominal obesity, is an independent indicator of increased cardiovascular risk. Observational studies have shown an observational association between obesity and venous thromboembolism (VTE). As a type of VTE, pulmonary embolism (PE) is also associated with obesity. However, it is unclear whether the observed associations are causal or caused by confounding bias or reverse causality.Methods We performed a two-sample test by obtaining the exposure dataset of waist circumference (WC) and hip circumference (HC) from the Neale Laboratory Consortium's genome-wide association study summary data and the summary-level outcome data of VTE and PE from FinnGen Biobank of European ancestry to determine the causal effect of WC and HC on VTE and PE.Results All three Mendelian randomization methods displayed a positive association between WC/HC and VTE/PE. WC and HC were positively associated with VTE (odds ratio [OR] = 1.803 per 1 standard deviation [SD] increase in WC, 95% confidence interval [CI] = 1.393–2.333; p < 0.001; OR = 1.479 per 1 SD increase in HC, 95% CI = 1.219–1.796; p < 0.001, respectively). Furthermore, we found a causal association between genetically predicted WC/HC and a higher risk of PE (OR = 1.929 per 1 SD increase in WC, 95% CI = 1.339–2.778, p < 0.001; OR = 1.431 per 1 SD increase in HC, 95% CI =1.095–1.869; p = 0.009, respectively).Conclusion There is a significant causal relationship between WC/HC and VTE/PE, which is consistent with observational studies. Taking measures to reduce WC/HC of obesity may help reduce the incidence of VTE/PE.
Lewis Acid Catalysed Asymmetric One-Carbon Ring-Expansion of Prochiral Cyclobutanones
Authors: Wahl Johannes M. , Tenberge Marius 
Published: November 2022

AbstractEnantioselective methylene insertion into prochiral cyclobutanones is described providing access to chiral β-substituted cyclopentanones as important structural motif in synthesis and natural products. Commercially available trimethylsilyl as well as other silyl diazomethanes act as one-carbon synthon and scandium triflate is found to be a potent Lewis acid catalyst. By using bis(oxazoline) ligands, enantioinduction is achieved for a number of β-substituted cyclopentanones including examples bearing all-carbon quaternary stereocentres.
Congenital Analbuminemia Associated with Hypothyroidism in a Preterm Neonate: The First Case from a Highly Consanguineous Community
Authors: Al-lawama Manar , Albaramki Jumana , Kiswani Arwa , Kussad Sara , Odeh Rasha , Altamimi Eyad 
Published: November 2022

AbstractAnalbuminemia is a rare autosomal recessive disease characterized by extremely low or zero levels of circulating serum albumin. The diagnosis is made by ruling out other causes of hypoalbuminemia and should be confirmed by gene mutation analysis. In this article, we describe the clinical findings of a preterm neonate born to a consanguineous family who presented with progressive lower limb edema at the age of 7 days and who was confirmed as having congenital analbuminemia by genetic testing (homozygous mutation ALB NP_000468.1: p. Val78CysfsTer2) and hypothyroidism. This is the first case of congenital analbuminemia to be reported from Jordan.
Anticoagulation and Antiplatelet Agents in Peripheral Arterial Interventions
Authors: Taylor Jordan , Stiepel Henry R. , Keefe Nicole 
Published: November 2022

AbstractEffective revascularization of peripheral artery disease relies on periprocedural pharmacological regulation of the clotting cascade. Patient-specific factors such as cardiovascular risk factors, contraindications, and individual psychosocial factors must be considered when initiating post revascularization management. Management with anticoagulant and antiplatelet agents is discussed to guide the interventionalist on which therapy may be appropriate for their patient. While exact treatment may be institution and provider dependent, the interventionist must be familiar with the available classes of medications and how they can be prescribed in the postprocedural setting to improve cardiovascular outcomes.
Local Anesthesia in Interventional Radiology
Authors: Li Xin , Trerotola Scott O. 
Published: November 2022

AbstractInterventional radiology is an evolving field that treats a variety of diseases. Local anesthetics is an important component of pain management during interventional radiologic procedures. It is highly effective and generally safe for routine procedures. However, local anesthetics can be associated with painful initial injection, allergic reactions, and rare but potentially devastating systemic toxicities. Recent evidence has shown that buffered solution and warm local anesthetics may reduce injection discomfort and improve clinical efficacy. Sensible safety practices and prompt recognition/treatment of the systemic toxicity are of paramount importance to provide safe local anesthesia. Interventional radiologists should be familiar with the basic pharmacology, common local anesthetics, optimizing strategies, complications, and management to provide safe and effective local anesthesia for patients.
Being Small for Gestational Age does not Change Short-Term Outcomes for Extremely Low Birth Weight Babies at Townsville University Hospital
Authors: Williamson Natalee , Alcock Gary , Kandasamy Yoga 
Published: November 2022

Abstract
Aim To determine whether being small for gestational age (SGA) is associated with increased mortality and short-term morbidity for extremely low birth weight (ELBW) babies at Townsville University Hospital (TUH).
Methods All babies with a birth weight of <1,000 g born at TUH between January 1, 2010 and January 1, 2021 were included. Data from the neonatal unit's NeoDATA database were used to compare mortality and short-term morbidity outcomes for babies categorized as SGA (birth weight <10th centile) or not. Statistical analyses were used to determine associations between being SGA and survival to discharge, intubation for mechanical ventilation, duration of respiratory support, chronic neonatal lung disease (CNLD), home oxygen, intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL), retinopathy of prematurity (ROP), necrotizing enterocolitis (NEC), sepsis, time to full enteral feeds, and duration of admission.
Results Of 461 ELBW babies, 62 (13.4%) were SGA. The SGA babies were significantly smaller at 714 (580–850) versus 810 (700–885) g (p < 0.001) and of advanced gestational age at 28.6 (26.6–30.2) versus 25.4 (24.4–26.6) weeks (p < 0.001). No significant difference in mortality existed, with 85% of SGA babies and 84% of others surviving. On univariate analysis, being SGA was associated with significant reductions in intubation for mechanical ventilation (p < 0.001), duration of respiratory support (p < 0.001), intraventricular hemorrhage (p = 0.002), NEC (p = 0.037), and admission duration (p = 0.038). After controlling for confounding factors, no outcomes were independently associated with being SGA. Logistic regression found survival was associated with birth weight (p = 0.030), gestational age (p = 0.007), and antenatal corticosteroids (p = 0.008).
Conclusions Being SGA is not an independent predictor of mortality nor adverse short-term morbidity for ELBW babies.
Drug-Eluting Stents
Authors: Velagapudi Chetan , Madassery Sreekumar 
Published: November 2022

AbstractEndovascular revascularization strategies have advanced tremendously over the years and are now often considered first line for treatment of peripheral arterial disease. Drug-eluting stents (DESs) have been developed as one of the tools to overcome the limitations of elastic recoil and neointimal hyperplasia observed with balloon angioplasty and bare metal stents. While these stents have been extremely successful in coronary revascularization, they have not translated as effectively to the peripheral arteries which differ in their unique mechanical environments and differences in vessel and lesion composition. DESs, through their embedded pharmaceutical agent, seek to inhibit vascular smooth muscle cell (VSMC) proliferation and migration. Paclitaxel, sirolimus, and its derivatives (-limus family) achieve VSMC inhibition through unique mechanisms. Several clinical trials have been performed to evaluate the use of DES in the femoropopliteal and infrapopliteal territory and have demonstrated overall decrease in revascularization rates and improved clinical outcomes.
Revisiting key debates in the study of nationalism
Authors: Dar Abdul Maajid 
Published: November 2022

AbstractThe purpose of this article is to lay out the debates and arguments around three key broader issues that dominate nationalism studies: (a) the meaning of a nation and nationalism and the relationship between political and cultural nationalism; (b) the origins and character of nations and nationalism; and (c) the civic-ethnic dichotomy and the relationship between nationalism and liberalism. It does not aim to provide definitive answers to the complex problems associated with nations and nationalism but rather to provide an overview of these debates by examining the existing literature on nations and nationalism. The final section discusses the position of new approaches to nations and nationalism and how they have problematised the key assumptions of the mainstream understanding of nationalism. The article, in light of an overview of the literature, draws four important conclusions. First, the academic journey of nationalism has reached a stage where the current consensus is that nations are socially constructed and historically contingent phenomena, and the current focus of the scholarship is on looking at the intersection between the cultural and political aspects of nationalism. Second, nations and nationalism possess a multifaceted character with particularity, subjectivity, and relativity as their defining features, representing that a single, universal explanation of nationalism is neither feasible nor morally desirable. Third, to understand the multiplicity and diversity of nations and nationalism and the ways in which elements of this multidimensionality intersect, it is necessary to treat them as open-ended, unstable, dispersed, protean, particular, and contingent phenomena. Finally, deep contestation constitutes a source of power and strength for nations and nationalism.
Remnant-movement analysis of questions with final wh-words in Jordanian Arabic
Authors: Jarrah Marwan , Al-Shawashreh Ekab 
Published: November 2022

Abstract
This paper investigates a subclass of questions in which the wh-word appears question-finally in Jordanian Arabic. It proposes that such questions are syntactically derived by two movements. First, the wh-word moves to the Spec of Focus Phrase in the left periphery of the question (cf. Rizzi, 1997). This is followed by the movement of the remnant TP to a higher position in the left periphery (the Spec of Topic Phrase), c-commanding the already-moved wh-word. Pragmatic and syntactic evidence is provided to motivate this analysis. Two competing alternatives of the derivation of these questions (the in-situ analysis and the right-ward movement of final wh-words) are discussed and rejected based on empirical evidence.
Development of L2 writing complexity
Authors: Dirdal Hildegunn 
Published: November 2022

Abstract
Recent research on complexity development has demonstrated the need to distinguish between specific types of subordinate clauses and consider L1 influence and individual variation. The present study combines these factors and makes finer distinctions between clause types than usual in complexity research. A case study following five Norwegian learners of English over four years shows that individual clause types have different developmental trajectories and that learners may develop in syntactic diversity even when showing little change in amount of subordination. A lack of specific clause types in the L1 can lead to late development of these in the L2, and higher uses of subordination in particular areas may boost complexity in the L2. Individual differences were found mainly in pace.
Microscopic calculation of the electromagnetic dipole strength for 239,243Pu isotopes
Authors: Yakut H , Tabar E , Kemah E , Hoşgör G 
Published: November 2022

Abstract
This work investigates the electric and magnetic dipole (E1 and M1) responses for 239,243Pu isotopes based on the quasiparticle phonon nuclear model, which was complemented by adding, for the first time, residual interactions for addressing the violations of rotational, translational, and Galilean symmetries caused by the mean-field approach. We focus on the E1 and M1 dipole strengths and photoabsorption cross sections up to 20 MeV, with the results revealing that the giant dipole resonance best describes the experimental trend with a ratio of 95%. It appears that most of the E1 strength is found at Ex
= 8–20 MeV, but the total B(E1)↑ strength for the pygmy dipole resonance at Ex
= 4–8 MeV accounts for some 1.83 e2fm2, which in turn corresponds to 2% of the Thomas–Reiche–Kuhn sum rule. Furthermore, the resultant total B(M1)↑ value for the scissors mode strength below 4 MeV is 5.65

μ

N

2

,

which is below that of the Oslo data (10.1(15)

μ

N

2

). However, the theoretically predicted scissors resonance structure has two peaks in the 1–3.5 MeV energy range, so it exhibits a similar trend to that found in the Oslo data.