bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Pilot Study to Develop the Rapid Estimate of Adult Literacy in Audiology
Authors: Ou Hua 
Published: May 2022

Background:
Health literacy describes an individuals' ability to maximize their potential in health care, including one's ability to understand information needed to make informed health decisions. A variety of general and condition-specific health literacy assessment tools have been created to help health professionals assess patients' health literacy skills and tailor the need for health care communication or education; however, there are no such tools available for the audiology field.

Objective:
The purpose of the study was to develop an objective reading recognition audiology-related health literacy assessment tool, the Rapid Estimate of Adult Literacy in Audiology (REALA).

Methods:

This was a cross-sectional study (
N
= 200). The initial version of the REALA contained 99 words specifically related to audiology. The final version, revised to have improved clinical utility, contained a total of 48 words that were selected based on item difficulty, item discrimination score, and point-biserial index using classical item analysis.

Key Results:
The total pass rate for the final version of the 48-word REALA was 0.72 (standard deviation = 0.45) and the Cronbach coefficient alpha was 0.93. Once the comprehension component is added to the tool, the REALA can be a valuable health literacy assessment tool that health professionals use to evaluate patients' audiology-related health literacy.

Conclusion:

Once the comprehension component is added to the tool, the REALA can be a valuable health literacy assessment tool that health professionals use to evaluate patients' audiology-related health literacy.

[
HLRP: Health Literacy Research and Practice
. 2022;6(2):e88–e95.]

Plain Language Summary:
A health literacy assessment tool, the REALA, was developed in the study. The final version of REALA contained 48 words relative to hearing healthcare. The results suggested that REALA can help health professionals assess patients' hearing related health literacy and tailor the need for hearing health care communication or education.
Professional Responsiveness to Health Literacy: A Scoping Review
Authors: Cesar Flaviane Cristina Rocha , Moraes Katarinne Lima , Brasil Virgínia Visconde , Alves Angela Gilda , Barbosa Maria Alves , Oliveira Lizete Malagoni de Almeida Cavalcante 
Published: May 2022

Background:
Difficulty in understanding and using health information can harm the patient and increase the cost of care provided. So, this study classified and mapped the characteristics and interventions that make health care professionals responsive to the patient's health literacy.

Methods:
Medline (PubMed), CINAHL (EBSCO), PsycInfo, ERIC (ProQuest), Lilacs (BVS) and EMBASE (Elsevier) were searched using a combination of controlled descriptors. The selected studies needed to address the concept or main focus of the study among health care professionals in the care or academic environment.

Key Results:

After reviewing 34 articles, 14 definitions and 10 subcategories of responsiveness were identified, and a broad characterization of health professional responsiveness to health literacy was proposed. Professional responsiveness to health literacy was characterized as knowing the definition and implications of health literacy for the patient's well-being and being able to develop, adapt, implement, and evaluate health education strategies. Nineteen strategies were mapped for education to ensure professional responsiveness to health literacy, classified as (A) expository (
n
= 18; 94.7%), (B) interactive (
n
= 9; 47.4%), (C) practice with educational materials (
n
= 2; 10.5%), (D) practice with standardized patient or simulation (
n
= 8; 42.1%), and (E) practice with actual patients (
n
= 4; 21.1%).

Discussion:

These characteristics and interventions provide a useful taxonomy for the development of curricula and professional education programs, and for the validation and use of measures to evaluate the health workforce. [

HLRP: Health Literacy Research and Practice
. 2022;6(2):e96–e103.

]

Plain Language Summary:
We found 14 definitions and 10 categories of professional responsiveness to health literacy. Professional responsiveness to health literacy was characterized as knowing the definition and implications of health literacy for the patient's well-being and being able to develop, adapt, implement, and evaluate health education strategies. Nineteen strategies were mapped for education to ensure professional responsiveness to health literacy.
La transmission d’un métier et l’exercice d’un travail : limites et avantages de genre (Rome, xviie-xviiie siècle)
Authors: Groppi Angela 
Published: May 2022

C’est un texte singulier et original de la grande historienne italienne Angela Groppi (1947-2020) que nous choisissons ici de publier. Tapuscrit d’une communication qu’elle avait présentée lors de la journée d’étude Femmes, droits, travail à l’époque moderne (Normandie/Europe) organisée par Anna Bellavitis le 13 mars 2015 à Rouen, il est un témoignage de tout un pan d’une recherche au long cours à la croisée de l’histoire sociale des femmes et du genre, de l’histoire des métiers et des corporations ainsi que de l’histoire du droit à la propriété et de la gestion des biens.
Construire un système alimentaire territorial durable
Authors: Nougarèdes Brigitte , Giraud Sophie , Clément Camille , Ruault Claire , Lambert Carole , Rixen Annabel 
Published: May 2022

Cet article présente une démarche de concertation territoriale portée par le conseil de développement du Pays Cœur d’Hérault visant à organiser des « États généraux de l’alimentation et de l’agriculture durable » (EGAAD). Cette démarche a pour objectif à terme de développer un système alimentaire territorialisé durable (SATD) à l’échelle du Pays, territoire regroupant 77 communes et trois intercommunalités. Le dispositif de concertation territoriale, élaboré avec une équipe de recherche (INRAe-UMR Innovation) avait pour objectif de mobiliser tous les acteurs de l’approvisionnement alimentaire local, les consommateurs, les associations citoyennes et les élus afin de construire un diagnostic partagé et d’identifier les pistes d’action concrètes pour développer le SATD et construire une gouvernance agricole et alimentaire à l’échelle du Pays. La concertation territoriale conduite sur une année, a mobilisé divers dispositifs (études diagnostics, forums citoyens, groupes de travail, restitutions publiques…). La participation a été inégale au regard du dispositif de concertation déployé. Alors que celle des professionnels de l’approvisionnement alimentaire local est restée faible, celle de la société civile et des élus a crû au cours du processus. Toutefois, cette concertation a permis de remettre l’alimentation à l’agenda politique du Pays.
A Novel Method for Total IgE Purification from Human Serum
Authors: Badloe Fariza Mishaal Saiema , De Vriese Shauni , De Bruyn Carlier Tina , Vandersichel Elise , Scheffel Jörg , Maurer Marcus , Ring Johannes , Gutermuth Jan , Kortekaas Krohn Inge 
Published: May 2022

Abstract
For Ab purification, high-affinity chromatography is commonly used. This technique results in high-purity Abs, but it requires highly specific knowledge and equipment. Commercial kits for purification of IgE are not available. Therefore, we established a (to our knowledge) novel method for the purification of total IgE from human serum. Sera from 19 allergic and nonallergic patients were included. After depletion of polyclonal IgG, total serum IgE was captured using anti-human IgE Abs coupled to beads, eluted from the beads, and incubated with protein G–coupled beads to increase the final purity. Purity analysis and Ab detection were performed by Western blot. Total serum IgE and purified IgE concentrations were analyzed using ELISA. To determine their functionality, primary human mast cells were sensitized with purified IgE and activated with anti-IgE or a relevant allergen. CD63+ expression and histamine release were used as readout parameters. Concentrations of purified total IgE corresponded with the levels of total serum IgE. Minor fractions of IgE remained attached to the beads, confirming an effective elution of IgE Abs. Only minimal amounts of IgG were found in the purified IgE fractions, confirming a high purity of IgE. Mast cells sensitized with purified IgE and subsequent activation with anti-IgE Ab or a relevant allergen showed increased expression of CD63+ and increased histamine release. This (to our knowledge) novel method represents a highly effective and widely accessible approach for purification of human serum IgE, which can improve the use of IgE-based in vivo and in vitro models and contribute to allergy research.
Peripheral sTREM2-Related Inflammatory Activity Alterations in Early-Stage Alzheimer’s Disease
Authors: Weber Grace E , Khrestian Maria , Tuason Elizabeth D , Shao Yvonne , Pillai Jagan , Rao Stephen , Feng Hao , Zhou Yadi , Cheng Feixiong , DeSilva Tara M , Stauffer Shaun , Leverenz James B , Bekris Lynn M 
Published: May 2022

Abstract
Alzheimer’s disease (AD) has been linked to multiple immune system–related genetic variants. Triggering receptor expressed on myeloid cells 2 (TREM2) genetic variants are risk factors for AD and other neurodegenerative diseases. In addition, soluble TREM2 (sTREM2) isoform is elevated in cerebrospinal fluid in the early stages of AD and is associated with slower cognitive decline in a disease stage–dependent manner. Multiple studies have reported an altered peripheral immune response in AD. However, less is known about the relationship between peripheral sTREM2 and an altered peripheral immune response in AD. The objective of this study was to explore the relationship between human plasma sTREM2 and inflammatory activity in AD. The hypothesis of this exploratory study was that sTREM2-related inflammatory activity differs by AD stage. We observed different patterns of inflammatory activity across AD stages that implicate early-stage alterations in peripheral sTREM2-related inflammatory activity in AD. Notably, fractalkine showed a significant relationship with sTREM2 across different analyses in the control groups that was lost in later AD-related stages with high levels in mild cognitive impairment. Although multiple other inflammatory factors either differed significantly between groups or were significantly correlated with sTREM2 within specific groups, three inflammatory factors (fibroblast growth factor-2, GM-CSF, and IL-1β) are notable because they exhibited both lower levels in AD, compared with mild cognitive impairment, and a change in the relationship with sTREM2. This evidence provides important support to the hypothesis that sTREM2-related inflammatory activity alterations are AD stage specific and provides critical information for therapeutic strategies focused on the immune response.
The Role of Ictal Brain Single Photon-Emission Tomography in Refractory Epilepsy Complementary to Magnetic Resonance Imaging and Electroencephalogram – Our Experience
Authors: Benjamin Justin , Sunny Saumya Sara , Hephzibah Julie , Mathew David , Jasper Anitha , Thomas Maya , Shanthly Nylla , Oommen Regi 
Published: May 2022

Background:
Correct identification of the epileptogenic zone (EZ) is essential for surgical success for focal epilepsy. There are multiple modalities which are available for detecting the anatomical and the functional abnormalities. The purpose of this study was to determine the complementary role of ictal brain single photon-emission tomography (SPECT) in delineating the EZ in addition to electroencephalogram (EEG) and magnetic resonance imaging (MRI).

Methodology:
Clinical and diagnostic data from patients with refractory epilepsy undergoing ictal brain SPECT (IEBS), EEG, MRI between 2014 and 2019 were analyzed retrospectively. Tc99m-ethyl cysteinate dimer was administered intravenously during or within 30 s of onset of seizure activity.

Results:
Eighty-nine patients aged: Four months-32 years (median age: Eight years) were studied. The concordance of IEBS with MRI and EEG were studied. Among them, EEG was normal in 22 and abnormal in 67 (multifocal: 40, unifocal: 8, generalized: 19). MRI was normal in 36, abnormal in 26, nonspecific in 24 and not done in three patients. Of the 80 patients showing tracer uptake in IEBS, 14-multifocal uptake and 66-unifocal uptake (EEG and MRI were not showing any abnormality in 15 and 27 patients, respectively). Unifocal uptake in IEBS was concordant with EEG in 11 (16.67%) and MRI in 15 (27.72%). The concordance and nonconcordance of the results among the two imaging modalities or EEG assuming surgical site as the gold standard was noted. Twenty-two had undergone surgical removal of the EZ, 15 was conformable with MRI or IEBS.

Conclusion:
In patients with noncontributory EEG and MRI, IEBS could detect the epileptogenic focus. Therefore, depending entirely on EEG and MRI may limit its diagnosis. IEBS, MRI and EEG are complementary to each other in the detecting the epileptogenic focus.
Impact of Perceived Self-Efficacy Among Hypertensives in Adapting to Low Salt Diet
Authors: Elangovan Venmathi , Nirupama A.Y. 
Published: May 2022

Background:
Hypertension is a crucial health problem worldwide, and its snowballing epidemiology demands stern caution to increase the focus on this silent disease. Evidence exists that a considerable decline in salt consumption decreases blood pressure (BP) by around 5–7 mm of Hg systolic, in patients with increased BP.

Materials and Methods:
A cross-sectional study was conducted among known hypertensive patients attending a health-care setting for routine check-up. This included patients of both genders, diagnosed with hypertensive at least 3 months prior, irrespective of their adherence to medication. Thus, convenient sampling was used to recruit participants after obtaining informed consent. The participants, who did not consent or cases of emergency such as myocardial infarction, malignant hypertension or arrhythmias and association with confirmed diabetes mellitus, were excluded. The study tool consisted of prevalidated and semistructured interview schedule

Results:
Median (inter-quartile range) age of the study participants was 60 (15) years with 59% of the population constituting of females. The consumption of dietary sodium was observed to be 2–4 g/day among 74.3% (78) of the study participants, and >5 g among 22.8% (23) of the study participants. Nearly 70% of the participants had higher to moderate perceived self-efficacy scores indicating an overall higher self-efficacy among participants in adapting to the practice of salt restriction. Perceived self-efficacy scores negatively correlated with dietary sodium intake by Spearman's correlation (rho = −0.667,P< 0.001).

Conclusion:
The perceived self-efficacy scores of the participants showed a strong negative correlation with the dietary sodium intake, this may be an indication of need for self-motivation and patient participation in the control of factors such as restricted salt intake in patients with hypertension and warrants further research.
Effect of adipose derived stem cells on the survival rate of long random pattern skin flap in rats, and the underlying mechanism of action
Authors: Ding Sheng , Liu Yunfeng , Song Mingming , Jin Xinyuan , Liu Xiaojun , Zhao Rui , Sun Ran 
Published: May 2022

Purpose: To investigate the effect of adipose-derived stem cells (ADSCs) on the survival rate of long random pattern skin flaps in rats and the likely underlying mechanism.
Methods: Twenty (20) SPF-grade SD rats were randomly divided into control group and study group, with 10 rats in each group. Rats in the control group were given phosphate buffered saline (PBS), while rats in the study group received ADSCs. The survival rate of the skin flaps was compared between the 2 groups on day 7 after operation, while the levels of indices related to oxidative stress and inflammatory response were compared on the 7th and 14th days after operation.
Results: Necrosis in the study group was milder (p < 0.05). On the 7th post-operation day, the survival rate of rat skin flap in the study group was significantly higher than that in the control group (p < 0.05), but the MDA level in the study group was lower than that of the control group (p < 0.05). On the 14th day after the operation, the MDA level was decreased in the two groups (p < 0.05), with a lower MDA level in the study group than in the control group (p < 0.05).
Conclusion: ADSCs inhibit inflammatory response and reduces the level of oxidative stress after long random pattern skin flap transplantation in rats, thereby enhancing blood supply to the flap transplantation area and improving its survival rate. Thus, ADSCs have a potential clinical application in enhancing blood supply in skin transplantation.
MiR 19a promotes proliferation and inhibits apoptosis of placental trophoblasts via PTEN pathway
Authors: Zhou Jing , Ma Ning , Lu Weiying , Zhou Zhi , Liu Suju 
Published: May 2022

Purpose: To screen the micro-ribonucleic acids (miRNAs) in the pathological processes of preeclampsia (PE), and to assess their effects on the proliferation and apoptosis of HTR-8/SVneo cells.
Methods: The miRNAs in PE patients and healthy puerperae were screened out using miRNA microarray assay, and verified through low-throughput quantitative reverse transcription- polymerase chain reaction (qRT-PCR). The effects of expression level of miR-19a on proliferation and cycle of HTR-8/SVneo cells were determined using cell counting kit (CCK)-8 assay and propidium iodide (PI) staining, respectively. The influence of the expression level of miR-19a on apoptosis of HTR-8/SVneo cells was evaluated using Annexin V-fluorescein isothiocyanate (FITC)/PI staining. Subsequently, luciferase reporter gene assay, CCK-8 assay and Annexin V-FITC/PI staining were conducted, respectively.
Results: Serum miR-19a was significantly decreased in PE patients, and a high level of miR-19a led to increase in the proliferation of HTR-8/SVneo cells. Decreased level of miR-19a arrested HTR-8/SVneo cell cycle at G1 phase, while increase in the miR-19a level repressed the apoptosis of HTR-8/SVneo cells. The PTEN was a direct target of miR-19a, and overexpression of miR-19a promoted the activation of Akt signaling pathway, thereby significantly decreasing the expression levels of downstream phosphorylated p21/p21 (p-p21/p21), p-p27/p27 and p-glycogen synthase kinase-3 beta (GSK3β)/GSK3β. Compared with those in cells transfected with empty vectors, the pro-proliferative and anti-apoptotic effects of miR-19a weakened in HTR-8/SVneo cell lines with overexpressed PTEN.
Conclusion: MiR-19a targets PTEN in order to activate Akt signaling pathway, thereby promoting proliferation, and inhibiting apoptosis of HTR-8/SVneo cells. This provides new drug targets that can be investigated for future treatment of PE.
Smelting Experiments with Chalcopyrite Ore based on Evidence from the Eastern Alps
Authors: Rose Thomas , Hanning Erica , Klein Sabine 
Published: May 2022

In order to assess the fractionation of copper isotopes during smelting under reconstructed conditions, smelting experiments with chalcopyrite ore were conducted in built furnaces based on archaeometallurgical evidence from the Bronze Age Eastern Alps and ethnographic examples from Nepal. Two experimental series, S2 and S4 were chosen for analysis. Each series consisted of a number of roasting and smelting experiments with different experimental parameters, and both series yielded metallic copper. Each type of experiment, their outcomes, and observations made during them are described in detail to facilitate future experimental work. Both series differ significantly in their outcome. XRD analyses and chemical analyses were carried out to reveal the reasons for the observed differences. The chemistry of the obtained matte shows that roasting is pivotal for a successful smelting process and that two cycles of matte roasting and subsequent smelting can be sufficient to remove most of the sulphur and iron from the matte. Furthermore, different conditions in the shaft furnaces resulted in a more efficient oxidation of iron in series S4. During the subsequent smelting of the matte in the pit furnace, it was possible to extract larger amounts of metallic copper and sponge copper, as well as to produce a thin well-melted plate-like slag. The pit furnace did not always show clear traces of metallurgical activity and thus might not be identifiable in the archaeological records without chemical analysis of the pit lining and surrounding soil. Although more trials are needed to replicate the process, these experiments give a strong hint towards the reconstruction of the matte smelting process in the Bronze Age alpine area.
Issues of implementing the requirements of educational standards of a new generation
Authors: Solskaya I. Yu. , Grosheva N. B. 
Published: May 2022

The development of requirements for the content of education is due to the dynamics of the factors of the external environment, and, fi rst of all, the trends of economic development. The essence of the requirements lies in the closest approximation of the content of educational programs, regulated by federal educational standards, to the content of the practical activities of graduates, determined by professional standards.The conducted research is aimed at analyzing the methodological base for linking professional standards and federal state standards at the level of formation of competencies and indicators. A systematic approach to evaluating the model of educational activity made it possible to assess the change in the nature of the interaction between the requirements of the labor market and the ways to meet them within the framework of the content and main aspects of the quality of educational programs. The features of the implementation of relations between communities of employers in the process of forming professional standards and their translation into methods of evaluation tools, which are an integral part of professional educational programs, are presented.The article formulates the main results of the study, namely, the methodological problems of the quality of education and the direction of the scientifi c, methodological and organizational and methodological activities of educational organizations in the community with employers and regional bodies that coordinate the requirements for graduates.
ESTUDIO DE AUTOEFICACIA ACADÉMICA EN ESTUDIANTES UNIVERSITARIOS DE MEDICINA Y NUTRICIÓN
Authors: Aldana Susuky Mar , Castañeda Delfín José Cirilo , Rodríguez López Miriam Hazel 
Published: May 2022

La presente investigación propone el objetivo central de analizar la autoeficacia en estudiantes universitarios de las licenciaturas de médico cirujano y nutrición. Para tal fin, se aplicó el Inventario de Expectativa de Autoeficacia Académica (IEAA) formulado para medir el constructo a 294 estudiantes de la carrera de medicina y 208 de nutrición. Los resultados demuestran que las actividades donde los estudiantes muestran un mayor nivel de expectativas de autoeficacia son realizar cualquier trabajo académico que encargue el maestro y organizarse adecuadamente para entregar a tiempo los trabajos que encargue el maestro.
Abstract
The aim of this research is to analyze self-efficacy of undergraduate students in medical surgeon and nutrition majors. For this purpose, the Inventory of Academic Self-Efficacy Expectation (Inventario de Expectativa de Autoeficacia Académica-IEAA) formulated by Barraza (2010) was applied to measure the construct in 294 young students majoring in Medicine and 208 in Nutrition. Results show that the activities where students display a higher level of expectations of self-efficacy are; when performing any academic assignment requested by the teacher and organizing themselves adequately in order to hand them in on time.