bluuebunny/crossref_metadata_2025_split huggingface dataset:
The digital communication tools and citizens' relationship with local governments: a comparison of Georgian and Polish cities
Authors: Maziashvili Maia , Pleśniak Agnieszka , Kowalik Izabela 
Published: March 2022

This article aims to explore the impact of digital communication tools application by citizens and the perceived usefulness of social media on the relationship between citizens and local authorities. The data were gathered in April–September 2020 through a survey (CAWI) among citizens of Poznan, Poland (n=502), and Kutaisi, Georgia (n=504), and were analyzed with structural equation modeling. The findings show that the intensity of digital communication tools usage for participation in the city branding and the perceived usefulness of social media contribute to the lasting relationships between citizens and local authorities in both countries. The novelty of this research concerns comparing two countries with different levels of development. Georgia is a developing economy in Europe and is in the process of modernizing the local governance across the cities. Poland, however, is a mature economy with a post-transformation heritage, where its cities benefit from considerable experience in building and developing citizen participation policies. Furthermore, the research was conducted amid the COVID-19 pandemic and evidenced the growing popularity of digital tools adoption by citizens in city matters. This study contributes to understanding the impact of digital tools on the relationship between citizens and local authorities in terms of city brand management. Citizens' participation in the city branding process via various digital communication tools increased citizen commitment towards long-lasting collaboration with local authorities. Moreover, citizens' perception of social media usefulness positively influences their desire to engage in the city branding process online, supporting the trust-building and collaboration between citizens and local authorities. Points for practitioners The intensiveness of digital tools usage – governments should identify the tools already trusted and popular among their audience and employ those tools to a greater extent to maximize the chances of feedback, high citizen participation, and commitment. Citizens’ perception of social media – such characteristics as ease of use, transparency, ease of communication with the municipality, and safety encourage citizens to get involved in the city brand management process. Consequently, local authorities should consider the features mentioned above and develop the online tools quality.
Performance Outcomes and Return to Sport Following Metacarpal Fractures in Major League Baseball Players
Authors: Pagani Nicholas R. , Sudah Suleiman Y. , Moverman Michael A. , Puzzitiello Richard N. , Menendez Mariano E. , Guss Michael S. 
Published: March 2022

Background: Major League Baseball (MLB) players are at risk for metacarpal fractures; however, little is known regarding the impact of these injuries on future performance. The purpose of this study was to determine whether MLB players who sustain metacarpal fractures demonstrate decreased performance on return to competition in comparison to the performance of control-matched peers. Methods: Data for MLB position players with metacarpal fractures incurred over 17 seasons were obtained from injury reports, press releases, and player profiles. Age, position, career experience, body mass index (BMI), injury mechanism, handedness, and treatment were recorded. Individual season statistics for the 2 seasons immediately before injury and the 2 seasons after injury were obtained. Controls matched by player position, age, BMI, career experience, and performance statistics were identified. A performance comparison of the cohorts was performed. Results: Overall, 24 players met inclusion criteria. Eleven players with metacarpal fractures were treated with surgery (46%) and 13 (54%) were treated nonoperatively. Players treated nonoperatively missed significantly fewer games following injury compared with those treated operatively (35.5 vs 52.6 games, P = .04). There was no significant difference in postinjury performance when compared with preinjury performance among the fracture cohorts. Players with metacarpal fractures treated nonoperatively had a significant decline in their Wins Above Replacement (WAR) 2 seasons postinjury (1.37 point decline) in comparison to matched controls (0.84 point increase) ( P = .02). There was no significant difference in WAR 1 or 2 seasons postinjury for players with metacarpal fractures treated operatively in comparison to the control cohort. Conclusions: Major League Baseball players sustaining metacarpal fractures can expect to return to their preinjury performance levels following both nonoperative and operative treatment. However, players treated nonoperatively may witness a decline in their performance compared with peers over the long term. Orthopedic surgeons treating professional athletes with metacarpal fractures should consider these outcomes when counseling their patients and making treatment recommendations.
A rare case of penile schwannomatosis presenting with painful nocturnal penile tumescence
Authors: Tow Chan Ming , Tang Jonathan , Chun Chan Ming , Chien Joe Lee King 
Published: March 2022

Abstract
Background
Penile schwannoma is a rare tumor. They commonly present as an asymptomatic, painless and slow growing mass. Other presentations include sexual dysfunction, most commonly dyspareunia, followed by erectile dysfunction, abnormal penile curvature or pain with ejaculation.

Case presentation
A 26-year-old male presented atypically with painful nocturnal penile tumescence, along with multiple nodules over the dorsal penis. Excision of multiple penile tumors under general anaesthesia was performed and histopathologic examination revealed benign schwannoma.

Conclusion
Our hypothesis is that the schwannoma lies along the axis of the dorsal penile nerve, and compression of this nerve occurs during his erection causing pain. However, there are limited presentations of painful erections in penile schwannomas, and we hope that future studies can help confirm this theory.
Big data ordination towards intensive care event count cases using fast computing GLLVMS
Authors: Caraka Rezzy Eko , Chen Rung-Ching , Huang Su-Wen , Chiou Shyue-Yow , Gio Prana Ugiana , Pardamean Bens 
Published: March 2022

Abstract
Background
In heart data mining and machine learning, dimension reduction is needed to remove multicollinearity. Meanwhile, it has been proven to improve the interpretation of the parameter model. In addition, dimension reduction can also increase the time of computing in high dimensional data.

Methods
In this paper, we perform high dimensional ordination towards event counts in intensive care hospital for Emergency Department (ED 1), First Intensive Care Unit (ICU1), Second Intensive Care Unit (ICU2), Respiratory Care Intensive Care Unit (RICU), Surgical Intensive Care Unit (SICU), Subacute Respiratory Care Unit (RCC), Trauma and Neurosurgery Intensive Care Unit (TNCU), Neonatal Intensive Care Unit (NICU) which use the Generalized Linear Latent Variable Models (GLLVM’s).

Results
During the analysis, we measure the performance and calculate the time computing of GLLVM by employing variational approximation and Laplace approximation, and compare the different distributions, including Negative Binomial, Poisson, Gaussian, ZIP, and Tweedie, respectively. GLLVMs (Generalized Linear Latent Variable Models), an extended version of GLMs (Generalized Linear Models) with latent variables, have fast computing time. The major challenge in latent variable modelling is that the function $$f\left(\varTheta \right)=\int f\left(u\varTheta \right)h\left(u\right)du$$

f

Θ

=
∫
f

u
Θ

h

u

d
u

is not trivial to solve since the marginal likelihood involves integration over the latent variable u.

Conclusions
In a nutshell, GLLVMs lead as the best performance reaching the variance of 98% comparing other methods. We get the best model negative binomial and Variational approximation, which provides the best accuracy by accuracy value of AIC, AICc, and BIC. In a nutshell, our best model is GLLVM-VA Negative Binomial with AIC 7144.07 and GLLVM-LA Negative Binomial with AIC 6955.922.
Influence of radiation dose and predicted tumor invasion depth on local recurrence after definitive chemoradiotherapy for stage 0–I esophageal squamous cell carcinoma: a propensity score-weighted, retrospective, observational study
Authors: Ikawa Toshiki , Ishihara Ryu , Matsueda Katsunori , Konishi Koji , Yamamoto Sachiko , Morimoto Masahiro , Kanayama Naoyuki , Teshima Teruki 
Published: March 2022

Abstract
Background
The optimal radiation dose for treating non-metastatic superficial esophageal squamous cell carcinoma is unknown. In this retrospective observational study, we investigated the influence of radiation dose and pretreatment endoscopic prediction of tumor invasion depth on local recurrence after definitive chemoradiotherapy in patients with superficial esophageal squamous cell carcinoma.

Methods
We analyzed 134 patients with clinical Tis–T1N0M0 esophageal squamous cell carcinoma who underwent chemoradiotherapy at our institution between 2006 and 2019. Patients were grouped into standard-dose (50.0–50.4 Gy) and high-dose (60.0 Gy) radiotherapy groups. The outcomes of interest were local recurrence and major local recurrence (endoscopically unresectable local recurrent tumors). Kaplan–Meier analysis and the log-rank test were used with propensity score and inverse probability of treatment weighting. Cox proportional hazards analysis was performed to identify predictors of local recurrence and major local recurrence.

Results
The median follow-up times were 52 and 84 months for the standard-dose and high-dose groups, respectively. The adjusted 3-year local recurrence and major local recurrence rates in the standard-dose and high-dose groups were 33.8 and 9.6% (adjusted hazard ratio, 4.00 [95% confidence interval: 1.64–9.73]; adjusted log-rank p = 0.001) and 12.5 and 4.7% (adjusted hazard ratio, 3.13 [95% confidence interval: 0.91–10.81]; adjusted log-rank p = 0.098), respectively. Cox proportional hazards analysis showed that standard-dose radiotherapy and endoscopic findings of deep submucosal invasion are independently associated with local recurrence and major local recurrence.

Conclusions
High-dose radiotherapy is more beneficial for local tumor control than standard-dose radiotherapy in patients with non-metastatic superficial esophageal squamous cell carcinoma. The use of high-dose radiotherapy may merit consideration for tumors with deep submucosal invasion.
Are children on track with their routine immunization schedule in a fragile and protracted conflict state of South Sudan? A community-based cross-sectional study
Authors: Idris Israel Oluwaseyidayo , Tapkigen Janet , Kabutaulaka Germaine , Ayeni Gabriel Omoniyi , Ayomoh Francis Ifeanyi , Obwoya Justin Geno 
Published: March 2022

Abstract
Objectives
The objective of this study was to assess if children aged 0–23 months in a conflict-affected state of South Sudan were on track with their immunization schedule and to identify predisposing factors that affected this study population from being on track with their routine immunization schedule.

Design
Community-based cross-sectional study using a semi-structured questionnaire. The binary outcome of interest was defined as being on or off track with routine vaccination schedule. Multivariable logistic regression was used to analyze for the association between the predisposing factors surveyed and being off track with one’s routine immunization schedule.

Setting
Rural communities in four counties (Rumbek Center, Rumbek North, Rumbek East and Wulu) of the Western Lakes state in South Sudan during January 10, 2020 to June 10, 2020.

Participants
We surveyed 428 children aged 0–23 months and their mothers/caregivers who lived in either of the four counties in the Western Lakes State. Participants were selected using random ballot sampling.

Results
More than three-quarters of the children surveyed (75.5%) were off track with their vaccination schedule. Children with an immunization card had 71% reduced odds of being off track with their immunization (AOR = 0.29; 95% CI 0.10–0.83, p-value = 0.021) compared to children without immunization cards. Children who reside near health facilities and do not require transportation to facilities had 87% reduced odds of being off track with their immunization compared to those who lived far and required transport to facilities. Giving an adequate immunization notice before conducting immunization outreach visits to communities was also associated with reduced odds (AOR = 0.27; 95% CI 0.09–0.78. p-value = 0.016) of children being off track with their immunization.

Conclusion
This study revealed that most children were off track with their vaccination schedule in South Sudan, which is not only influenced by maternal characteristics but mainly by community- and state-level immunization service delivery mechanisms. Policies and interventions to improve child immunization uptake should prioritize these contextual characteristics.
The relationship between motherhood and use of mental health care services among married migrant and non-migrant women: a national register study
Authors: Straiton Melanie , Hollander Anna-Clara , Hynek Kamila Angelika , Liefbroer Aart C. , Hauge Lars Johan 
Published: March 2022

Abstract
Background
Giving birth to one’s first child is a life changing event. Beyond the post-partum period, little is known about the association between becoming a mother and mental disorder among migrant women. This study investigates outpatient mental health (OPMH) service use, a proxy for mental disorder, among married migrant and non-migrant women who become mothers and those who do not.

Methods
Using Norwegian register data, we followed 90,195 married women, aged 18-40 years, with no children at baseline between 2008-2013 to see if becoming a mother was associated with OPMH service use. Data were analysed using discrete time analyses.

Results
We found an interaction between motherhood and migrant category. Married non-migrant mothers, both in the perinatal period and beyond, had lower odds of OPMH use than married non-mothers. There was no association between motherhood and OPMH service use for migrants. However, there was no significant interaction between motherhood and migrant category when we excluded women who had been in Norway less than five years. Among women aged 25-40 years, a stable labour market attachment was associated with lower odds of OPMH use for non-migrants but not migrants, regardless of motherhood status.

Conclusions
The perinatal period is not associated with increased odds of OPMH use and appears to be associated with lower odds for married non-migrant women. Selection effects and barriers to care may explain the lack of difference in OPMH service use that we found across motherhood status and labour market attachment for married migrant women. Married migrant women in general have a lower level of OPMH use than married non-migrants. Married migrant women with less than five years in Norway and those with no/weak labour market attachment may experience the greatest barriers to care. Further research to bridge the gap between need for, and use of, mental health care among migrant women is required.
Tobacco use prevalence and its determinate factor in Ethiopia- finding of the 2016 Ethiopian GATS
Authors: Mengesha Sisay Derso , Teklu Kirubel Tesfaye , Weldetinsae Abel , Serte Melaku Gizaw , Kenea Moa Abate , Dinssa Daniel Abera , Woldegabriel Mesay Getachew , Alemayehu Tsigereda Assefa , Belay Wassihun Melaku 
Published: March 2022

AbstractBackgroundTobacco, one of the risk factors for non-communicable diseases, kills 8 million people each year. Like other sub-Saharan countries, Ethiopia faces the potential challenge of a tobacco epidemic. However, there is no organized data on the prevalence of tobacco use in the country. Therefore, this study aims to determine adult tobacco use in Ethiopia.MethodsThe study was conducted using the WHO and CDC GATS survey methods. Complex survey analysis was used to obtain prevalence and population estimates with 95% confidence intervals. Bivariate regression analyses were employed to examine factors related to tobacco use.ResultsThe overall tobacco use percentage was 5.0% [95% CI (3.5, 6.9)], of which 65.8% [95% CI (53.4, 76.3)] only smoked tobacco products; 22.5% [95% CI (15.7, 31.2)] used smokeless tobacco only; and 11.8% [95% CI (6.5, 20.4)] used both smoked and smokeless tobacco products. In 2016, more men adults (8.1%) used tobacco than women did (1.8%). Eight out of eleven states have a higher smoking rate than the national average (3.7%). Gender, employment, age, religion, and marital status are closely linked to current tobacco use (p-value< 0.05). Men adults who are employed, married, and mostly from Muslim society are more likely to use tobacco.ConclusionThe prevalence of tobacco use is still low in Ethiopia. However, the percentage of female smokers is increasing, and regional governments such as Afar and Gambella have a relatively high prevalence. This calls for the full implementation of tobacco control laws following the WHO MPOWER packages. A tailored tobacco control intervention targeting women, younger age groups, and regions with a high proportion of tobacco use are recommended.
No man is an island: management of the emergency response to the SARS-CoV-2 (COVID-19) outbreak in a large public decentralised service delivery organisation
Authors: Ohrling Mikael , Solberg Carlsson Karin , Brommels Mats 
Published: March 2022

Abstract
Background
We wanted to better understand whether and how agility can be achieved in a decentralised service delivery organisation in Sweden. The pandemic outbreak of SARS-Cov-2 (Covid-19) provided an opportunity to assess decentralisation as a strategy to improve the responsiveness of healthcare and at the same time handle an unpredictable and unexpected event.

Methods
Data from in-depth interviews with a crisis management team (n = 23) and free text answers in a weekly survey to subordinated clinical directors, i.e. unit managers, (n = 108) were scrutinised in a directed content analysis. Dynamic capabilities as a prerequisite for dynamic effectiveness, understood as reaching strategic and operative effectiveness simultaneously, were explored by using three frameworks for dynamic effectiveness, dynamic capabilities and delegated authority in a decentralised organisation.

Results
Unpredictable events, such as the pandemic Covid-19 outbreak, demand a high grade of ability to be flexible. We find that a high degree of operational effectiveness, which is imperative in an emergency situation, also is a driver of seeking new strategic positions to even better meet new demands. The characteristics of the dynamic capabilities evolving from this process are described and discussed in relation to decentralisation, defined by decision space, organisational and individual capacity as well as accountability. We present arguments supporting that a decentralised management model can facilitate the agility required in an emergency.

Conclusions
This study is, to our knowledge, the first of its kind where a decentralised management model in a service delivery organisation in healthcare is studied in relation to crisis management. Although stemming from one organisation, our findings indicating the value of decentralisation in situations of crisis are corroborated by theory, suggesting that they could be relevant in other organisational settings also.
Comparison of tumor and two types of paratumoral tissues highlighted epigenetic regulation of transcription during field cancerization in non-small cell lung cancer
Authors: Wang Qiushi , Wu Libo , Yu Jiaxing , Li Guanghua , Zhang Pengfei , Wang Haozhe , Shao Lin , Liu Jinying , Shen Weixi 
Published: March 2022

Abstract
Background
Field cancerization is the process in which a population of normal or pre-malignant cells is affected by oncogenic alterations leading to progressive molecular changes that drive malignant transformation. Aberrant DNA methylation has been implicated in early cancer development in non-small cell lung cancer (NSCLC); however, studies on its role in field cancerization (FC) are limited. This study aims to identify FC-specific methylation patterns that could distinguish between pre-malignant lesions and tumor tissues in NSCLC.

Methods
We enrolled 52 patients with resectable NSCLC and collected resected tumor (TUM), tumor-adjacent (ADJ) and tumor-distant normal (DIS) tissue samples, among whom 36 qualified for subsequent analyses. Methylation levels were profiled by bisulfite sequencing using a custom lung-cancer methylation panel.

Results
ADJ and DIS samples demonstrated similar methylation profiles, which were distinct from distinct from that of TUM. Comparison of TUM and DIS profiles led to identification of 1740 tumor-specific differential methylated regions (DMRs), including 1675 hypermethylated and 65 hypomethylated (adjusted P < 0.05). Six of the top 10 tumor-specific hypermethylated regions were associated with cancer development. We then compared the TUM, ADJ, and DIS to further identify the progressively aggravating aberrant methylations during cancer initiation and early development. A total of 332 DMRs were identified, including a predominant proportion of 312 regions showing stepwise increase in methylation levels as the sample drew nearer to the tumor (i.e. DIS < ADJ < TUM) and 20 regions showing a stepwise decrease pattern. Gene set enrichment analysis (GSEA) for KEGG and GO terms consistently suggested enrichment of DMRs located in transcription factor genes, suggesting a central role of epigenetic regulation of transcription factors in FC and tumorigenesis.

Conclusion
We revealed distinct methylation patterns between pre-malignant lesions and malignant tumors, suggesting the essential role of DNA methylation as an early step in pre-malignant field defects. Moreover, our study also identified differentially methylated genes, especially transcription factors, that could potentially be used as markers for lung cancer screening and for mechanistic studies of FC and early cancer development.
Roles of sirtuin family members in chronic obstructive pulmonary disease
Authors: Zhang Xi-Yue , Li Wei , Zhang Jin-Rong , Li Chun-Yan , Zhang Jie , Lv Xue-Jiao 
Published: March 2022

AbstractThe globally increasing annual incidence of chronic obstructive pulmonary disease (COPD), a common chronic disease, poses a serious risk to public health. Although the exact mechanism underlying the pathogenesis of COPD remains unclear, a large number of studies have shown that its pathophysiology and disease course are closely related to oxidative stress, inflammation, apoptosis, autophagy, and aging. The key players involved in COPD include the sirtuin family of NAD-dependent deacetylases that comprise seven members (SIRT1–7) in mammals. Sirtuins play an important role in metabolic diseases, cell cycle control, proliferation, apoptosis, and senescence. Owing to differences in subcellular localization, sirtuins exhibit anisotropy. In this narrative review, we discuss the roles and molecular pathways of each member of the sirtuin family involved in COPD to provide novel insights into the prevention and treatment of COPD and how sirtuins may serve as adjuvants for COPD treatment.