bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rational Design of Multifunctional CuS Nanoparticle‐PEG Composite Soft Hydrogel‐Coated 3D Hard Polycaprolactone Scaffolds for Efficient Bone Regeneration
Authors: Xue Xu , Zhang Hao , Liu Han , Wang Sicheng , Li Jiadong , Zhou Qirong , Chen Xiao , Ren Xiaoxiang , Jing Yingying , Deng Yonghui , Geng Zhen , Wang Xiuhui , Su Jiacan 
Published: June 2022

Abstract3D‐printed polycaprolactone (PCL) scaffolds have been extensively studied for application in bone tissue engineering. However, PCL‐based scaffolds with enhanced bioactivity and intelligent delivery capability for bone repair remains challenging. Herein, CuS nanoparticle‐PEG soft hydrogel‐coated 3D hard polycaprolactone scaffolds (denoted as CuS‐PEG‐PCL scaffold) are rationally designed for efficient bone regeneration. CuS nanoparticles cross‐linked PEG hydrogel (CuS‐PEG‐hydrogel) endows the PCL‐based scaffold with excellent photothermal properties and stable soft elasticity, while the PCL scaffold provides excellent mechanical performance. Upon exposure to 1064 nm near‐infrared (NIR) light irradiation, dexamethasone sodium phosphate (Dexp), stored in the CuS‐PEG‐PCL scaffold, can be controllably released, which efficiently promotes osteogenic differentiation of bone mesenchymal stem cells (BMSCs). In addition, the combination of mild heating at 42 ± 0.5 °C further promoted osteogenic differentiation of BMSCs. Subsequently, this Dexp‐loaded CuS‐PEG‐PCL scaffold (D‐CuS‐PEG‐PCL scaffold) with NIR light treatment at the tibial defect of rats presented the highest bone regeneration capacity. These findings demonstrate that the Dexp‐loaded CuS‐PEG‐hydrogel can effectively modify the 3D printed PCL scaffold. Therefore, this multifunctional scaffold with a soft‐hard hybrid structure has the potential to become an advanced drug delivery vehicle in the treatment of large bone defects.
Surface‐Decorated High‐Entropy Alloy Catalysts with Significantly Boosted Activity and Stability
Authors: Zeng Kaizhu , Zhang Jianwei , Gao Wenqiang , Wu Lianping , Liu Hanwen , Gao Jinlong , Li Zezhou , Zhou Jihan , Li Teng , Liang Zhiqiang , Xu Bingjun , Yao Yonggang 
Published: June 2022

AbstractHigh‐entropy alloy (HEA) nanoparticles are emerging catalytic materials and are particularly attractive for multi‐step reactions due to their diverse active sites and multielement tunability. However, their design and optimization often involve lengthy efforts due to the vast multielement space and unidentified active sites. Herein, surface decoration of HEA nanoparticles to drastically improve the overall activity, stability, and reduce cost is reported. A two‐step process is employed to first synthesize non‐noble HEA (FeCoNiSn) nanoparticles and then are surface alloyed with Pd (main active site), denoted as NHEA@NHEA‐Pd. As a demonstration in the ethanol oxidation reaction, a high mass activity of 7.34 A mg−1Pd and superior stability (>91.8% retention after 2000 cycles) in NHEA@NHEA‐Pd are achieved, substantially outperforming traditional HEA, binary M@M‐Pd (M = Sn, Fe, Co, Ni), and commercial Pd/C. In situ spectroscopy reveals that NHEA@NHEA‐Pd can catalytically produce and oxidize CO at <0.5 V, which is >200 mV lower than Sn@Sn‐Pd, suggesting enhanced activity in NHEA@NHEA‐Pd owing to Pd's unique high‐entropy coordination environment. This work provides a novel design of HEA catalysts by combining surface decoration (exposing more active sites) and high‐entropy coordination (enhancing intrinsic activity and structural stability) to boost catalysts’ activity and durability.
Two‐Color Strip‐Patterned White OLEDs: Tunable Color‐Temperature via Pattern Dimension Control
Authors: Han Dongheon , Lee Myeongjae , Jang Wooik , Lee Seunghan , Yang Jeehye , Jo Hyunwoo , Lee Hojin , Kwak Kyungwon , Kim BongSoo , Kang Moon Sung 
Published: June 2022

AbstractWhite light is attained by combining different‐colored emissions. White organic light‐emitting diodes, therefore, should be fabricated to obtain mixed emissions from different organic luminophores while suppressing energy transfer between each other. Here, the authors present a simple means to realize this goal by forming two‐color strip‐patterns of light‐emitting polymer (orange) and an iridium complex (sky‐blue) luminophores entirely through solution processes. The formation of the two‐color patterns is facilitated by i) the use of a highly efficient crosslinker permitting the construction of structurally robust orange primary strip‐patterns and ii) the contrast in the surface energy allowing selective wetting of the secondary sky‐blue patterns between the orange primary patterns. The emissive layer comprising the two‐color strip ‐patterns allows for the mixing ratio of the two colors to be adjusted by simply varying the areal ratio of the two patterns, which in turn, controls the white emission color‐temperature from 2119 to 7994 K.
A Facile, Fabric Compatible, and Flexible Borophene Nanocomposites for Self‐Powered Smart Assistive and Wound Healing Applications
Authors: Chen Shuo‐Wen , Huang Shih‐Min , Wu Han‐Song , Pan Wei‐Pang , Wei Shih‐Min , Peng Chih‐Wei , Ni I‐Chih , Murti Bayu Tri , Tsai Meng‐Lin , Wu Chih‐I , Yang Po‐Kang 
Published: June 2022

AbstractSmart fabrics that can harvest ambient energy and provide diverse sensing functionality via triboelectric effects have evoked great interest for next‐generation healthcare electronics. Herein, a novel borophene/ecoflex nanocomposite is developed as a promising triboelectric material with tailorability, durability, mechanical stability, and flexibility. The addition of borophene nanosheets enables the borophene/ecoflex nanocomposite to exhibit tunable surface triboelectricity investigated by Kelvin probe force microscopy. The borophene/ecoflex nanocomposite is further fabricated into a fabric‐based triboelectric nanogenerator (B‐TENG) for mechanical energy harvesting, medical assistive system, and wound healing applications. The durability of B‐TENG provides consistent output performance even after severe deformation treatments, such as folding, stretching, twisting, and washing procedures. Moreover, the B‐TENG is integrated into a smart keyboard configuration combined with a robotic system to perform an upper‐limb medical assistive interface. Furthermore, the B‐TENG is also applied as an active gait phase sensing system for instantaneous lower‐limb gait phase visualization. Most importantly, the B‐TENG can be regarded as a self‐powered in vitro electrical stimulation device to conduct continuous wound monitoring and therapy. The as‐designed B‐TENG not only demonstrates great potential for multifunctional self‐powered healthcare sensors, but also for the promising advancements toward wearable medical assistive and therapeutic systems.
Piezo‐Electrocatalysis for CO2 Reduction Driven by Vibration
Authors: Ma Jiangping , Jing Shaojie , Wang Yang , Liu Xue , Gan Li‐Yong , Wang Cong , Dai Ji‐Yan , Han Xiaodong , Zhou Xiaoyuan 
Published: June 2022

AbstractWith rising CO2 emissions caused by the massive consumption of fossil fuels, it is highly desirable to develop strategies that adopt renewable energy to convert CO2 into value‐added chemical feedstocks. Over the past decades, photocatalytic reduction of CO2 using light energy has attracted considerable attention. However, the advanced photocatalysis techniques cannot exert their action where light is unavailable. Here, a method for CO2 reduction on basis of vibration‐driven piezoelectricity to yield a piezo‐electrocatalysis effect which requires mechanical vibration rather than light, is proposed. Under mild vibration and sacrificial agent‐free conditions, the piezoelectric BaTiO3 catalyst provides a suitable piezo‐potential to overcome the redox potential of CO2 and convert it into CO with a maximum yield of 63.3 µmol g−1, achieving a reactivity comparable to those of photocatalysts. The piezo‐electrocatalytic CO2 reduction reaction adds a new avenue in addition to the existing photocatalytic techniques by expanding the scope of energy utilization to promote carbon neutrality.
Alternative Benzoxazole Assembly Discovered in Anaerobic Bacteria Provides Access to Privileged Heterocyclic Scaffold
Authors: Horch Therese , Molloy Evelyn M. , Bredy Florian , Haensch Veit G. , Scherlach Kirstin , Dunbar Kyle L. , Franke Jonathan , Hertweck Christian 
Published: June 2022

AbstractBenzoxazole scaffolds feature prominently in diverse synthetic and natural product‐derived pharmaceuticals. Our understanding of their bacterial biosynthesis is, however, limited to ortho‐substituted heterocycles from actinomycetes. We report an overlooked biosynthetic pathway in anaerobic bacteria (typified in Clostridium cavendishii) that expands the benzoxazole chemical space to meta‐substituted heterocycles and heralds a distribution beyond Actinobacteria. The first benzoxazoles from the anaerobic realm (closoxazole A and B) were elucidated by NMR and chemical synthesis. By genome editing in the native producer, heterologous expression in Escherichia coli, and systematic pathway dissection we show that closoxazole biosynthesis invokes an unprecedented precursor usage (3‐amino‐4‐hydroxybenzoate) and manner of assembly. Synthetic utility was demonstrated by the precursor‐directed biosynthesis of a tafamidis analogue. A bioinformatic survey reveals the pervasiveness of related gene clusters in diverse bacterial phyla.
A Lattice‐Matching Strategy for Highly Reversible Copper‐Metal Anodes in Aqueous Batteries
Authors: Cai Haixia , Bi Songshan , Wang Rui , Liu Lili , Niu Zhiqiang 
Published: June 2022

AbstractCopper metal is an attractive anode material for aqueous rechargeable batteries due to its high theoretical specific capacity (844 mAh g−1), good environmental compatibility and high earth abundance. However, the Cu anodes often suffer from poor deposition/stripping reversibility and nonuniform deposition during the charge/discharge process, degrading the lifetime of aqueous Cu‐metal batteries. Herein, a lattice‐matching strategy was developed to design high‐performance Cu‐metal anodes. In such a strategy, Ni substrates that exhibit high lattice matching with Cu were selected to support the Cu anodes. The high lattice matching endows Cu anodes with high deposition/stripping reversibility, low nucleation overpotential as well as a uniform and dense electrodeposition on Ni substrates. Based on the Ni substrate‐supported Cu anodes, the full cells paired with lead dioxide cathodes show a stable cycling behavior. This work provides a route for the design of high‐performance Cu electrodes in aqueous rechargeable batteries.
Expanded Azaporphyrins Consisting of Multiple BODIPY Units: Global Aromaticity and High Affinities Towards Alkali Metal Ions
Authors: Rao Yutao , Xu Ling , Zhou Mingbo , Yin Bangshao , Osuka Atsuhiro , Song Jianxin 
Published: June 2022

AbstractThe one‐pot self‐coupling reaction of 3‐amino‐5‐bromo‐BODIPY 9 under Buchwald–Hartwig amination conditions gave nitrogen‐bridged cyclic BODIPY tetramer 10, pentamer 11, and hexamer 12. Oxidation of 10, 11, and 12 in the presence of alkali metal ions provided 13, 15, and 16, respectively, as the first examples of expanded azaporphyrins possessing more than six pyrrole rings. Curiously, the oxidation even in the absence of alkali metal ions gave the same complexes as a result of spontaneous complexation. 10–12 showed large association constants (104–106 M−1) with K+ and Na+, but the spontaneous complexations were not observed, indicating the extremely high affinities of 13–16 toward alkali metal ions, which can be ascribed to the multiple and effective ion–dipole interaction of the alkali metal ion with the negatively polarized F atoms of the BF2 walls surrounding the cavity. Importantly, 13, 14, and 15 show diatropic ring currents as a result of global aromaticity.
SCPA‐Net: Self‐calibrated pyramid aggregation for image dehazing
Authors: Chen Zhihua , Zhou Yu , Li Ran , Li Ping , Sheng Bin 
Published: June 2022

AbstractDehazing as an important image processing field has developed for many years, there exist many excellent methods for exploring more complex networks to solve this problem. In this paper, instead of designing a complex network structure, we propose a novel dehazing network based on the consideration of enhancing feature aggregation and feature representation abilities of dehazing architecture. Specifically, we propose a self‐calibrated pyramid aggregation network (SCPA‐Net) for image dehazing, which is based on an encoder‐decoder architecture. In the encoder, we build a self‐attention block as a unit to aggregate information from a neighborhood to adapt to its content. In the decoder, we introduce a self‐calibration block to capture long‐range spatial and channel dependencies to produce more discriminative representations. Finally, to learn the scale information, the pyramid upsampling structure is applied to aggregate the multiscale self‐calibrated attentive features. Experimental results show our SCPA‐Net can achieve impressive dehazing performance.
Therapeutic role of hesperidin in collagen‐induced rheumatoid arthritis through antiglycation and antioxidant activities
Authors: Ahmad Shafeeque , Mittal Shilpa , Gulia Rashmi , Alam Khursheed , Saha Tapan Kumar , Arif Zarina , Nafees K. A. , Al‐Shaghdali Khalid , Ahmad Saheem 
Published: June 2022

AbstractRheumatoid arthritis (RA), a chronic inflammatory disease, and its exact aetiology is not defined clearly. The free radicals produced in large amount in RA are associated with alteration in molecular structure resulting in glycation of proteins. As a result of glycation, advanced glycation end products (AGEs) produced. In this study, collagen type II suspension was injected into Wistar rats to make RA model of rats. Simultaneously, hesperidin 50 mg kg−1body weight was orally administrated to the rats for 21 days. X‐rays of the rat hind paws were analyzed and found to be significantly effective against bone loss after treatment with hesperindin. Nε‐(carboxymethyl)lysine (CML) and pentosidine (PTD) concentrations in collagen‐induced RA plasma were determined as 565.29 ± 30.15 and 37.23 ± 1.02 ng ml−1, respectively, while CML and PTD in IgG were 6.63 ± 0.44 ng mg−1IgG and 425.33 ± 37.26 ng g−1IgG, respectively. After treatment with hesperidin, the elevated levels of CML in plasma and in IgG were significantly (p < 0.001) lowered to 450.95 ± 15.05 mg ml−1and 5.23 ± 0.27 ng mg−1IgG, respectively. Similarly, concentrations of PTD in plasma and IgG of rats treated with hesperidin were 28.46 ± 1.20 ng ml−1and 359.35 ± 31.11 ng g−1IgG, respectively. Thus, after treatment with drug, plasma CML and IgG PTD levels were restored as 93% and 16%, respectively, through free radical scavenging activity of hesperidin resulting in alleviation of RA disease by decreasing the AGEs concentrations. Therefore, use of hesperidin may be useful to alleviate severity of RA disease.
Myricetin Inhibits α‐Synuclein Amyloid Aggregation by Delaying the Liquid‐to‐Solid Phase Transition
Authors: Xu Bingkuan , Mo Xiaoli , Chen Jing , Yu Haijia , Liu Yinghui 
Published: June 2022

AbstractThe aggregation of α‐synuclein (α‐Syn) is a critical pathological hallmark of Parkinson's disease (PD). Prevention of α‐Syn aggregation has become a key strategy for treating PD. Recent studies have suggested that α‐Syn undergoes liquid‐liquid phase separation (LLPS) to facilitate nucleation and amyloid formation. Here, we examined the modulation of α‐Syn aggregation by myricetin, a polyhydroxyflavonol compound, under the conditions of LLPS. Unexpectedly, neither the initial morphology nor the phase‐separated fraction of α‐Syn was altered by myricetin. However, the dynamics of α‐Syn condensates decreased upon myricetin binding. Further studies showed that myricetin dose‐dependently inhibits amyloid aggregation in the condensates by delaying the liquid‐to‐solid phase transition. In addition, myricetin could disassemble the preformed α‐Syn amyloid aggregates matured from the condensates. Together, our study shows that myricetin inhibits α‐Syn amyloid aggregation in the condensates by retarding the liquid‐to‐solid phase transition and reveals that α‐Syn phase transition can be targeted to inhibit amyloid aggregation.
Incidental detection of retained oil‐based hysterosalpingography contrast medium on postoperative postpartum radiography: A case report
Authors: Hayashida Harue , Furuya Kiichiro , Kurahashi Hiroki , Yamashita Saya , Chang Yangsil , Tsubouchi Hiroaki , Shikado Kayoko , Ogita Kazuhide 
Published: June 2022

AbstractHysterosalpingography is widely performed in assisted reproductive technology. We present a rare case of contrast medium retention which was incidentally found and mimicked a retained surgical instrument. A medical history of treatment for infertility can facilitate the differential diagnosis of abnormal findings on post‐caesarean section radiography.
On‐Surface Synthesis of Unsaturated Hydrocarbon Chains through C−S Activation
Authors: Giovanelli Luca , Pawlak Rémy , Hussein Fatima , MacLean Oliver , Rosei Federico , Song Wentao , Pigot Corentin , Dumur Frédéric , Gigmes Didier , Ksari Younal , Bondino Federica , Magnano Elena , Meyer Ernst , Clair Sylvain 
Published: June 2022

AbstractWe use an on‐surface synthesis approach to drive the homocoupling reaction of a simple dithiophenyl‐functionalized precursor on Cu(111). The C−S activation reaction is initiated at low annealing temperature and yields unsaturated hydrocarbon chains interconnected in a fully conjugated reticulated network. High‐resolution atomic force microscopy imaging reveals the opening of the thiophenyl rings and the presence of trans‐ and cis‐oligoacetylene chains as well as pentalene units. The chemical transformations were studied by C 1s and S 2p core level photoemission spectroscopy and supported by theoretical calculations. At higher annealing temperature, additional cyclization reactions take place, leading to the formation of small graphene flakes.
Room‐Temperature Synthesized Cd‐Doped Cs3Cu2I5: Stable and Excitation‐Wavelength Dependent Dual‐Color Emission for Advanced Anti‐Counterfeiting
Authors: Qu Junfeng , Xu Shuhong , Cui Yiping , Wang Chunlei 
Published: June 2022

AbstractWith the development of intellectual properties, concern about advanced anti‐counterfeiting is accumulating, which conventional single‐modal luminescence can no longer satisfy. As one of rapidly developing 0D materials, copper‐based perovskite shows great potential to realize multiple luminescent centers for complex emissions. In this work, Cd was doped into Cs3Cu2I5 and showed resultant emission at 560 nm which surprisingly showed a red‐shifted excitation peak from that of intrinsic self‐trapped emission, resulting in excitation‐wavelength dependent emission. When the excitation wavelength increased from 290 nm to 330 nm, the emission of Cd‐doped Cs3Cu2I5 changed from deep blue to cold white and finally yellow. Afterwards, Cd‐doped Cs3Cu2I5 was mixed with polystyrene to prepare anti‐counterfeiting ink for silk‐screen printing. Meanwhile, Cd‐doped Cs3Cu2I5 maintains outstanding stability after doping, no matter under ambient, continuous UV radiation or high‐temperature environment. The intensity can be almost totally recovered after heating‐and‐cooling cycles. This study lays groundwork for future research into multiple luminescent center manipulation in 0D materials.
Understanding the Reshaping of Fluorinated Polyester Vitrimers by Kinetic and DFT Studies of the Transesterification Reaction
Authors: Lemouzy Sébastien , Cuminet Florian , Berne Dimitri , Caillol Sylvain , Ladmiral Vincent , Poli Rinaldo , Leclerc Eric 
Published: June 2022

AbstractVitrimers are a third class of polymers gathering the mechanical properties and solvent resistance of 3D thermosets and the reprocessability of thermoplastics. This unique behaviour is due to the triggering of certain covalent exchange reactions that allow the network to rearrange upon application of a stimulus. The constitutive feature of vitrimers is the adoption of a glass‐like viscosity during the rearrangement of the network, often due to an associative mechanism for the exchange reaction. Transesterification networks are one of the most studied type of vitrimers that usually require the incorporation of a catalyst, implying the associated drawbacks. Following up on a recent report on catalyst‐free transesterification vitrimers in which the ester functions are particularly reactive thanks to the presence of fluorine atoms in α‐ or β‐position, parallel DFT calculations and an experimental kinetic study on model molecules are presented in order to quantitatively assess the effect of neighbouring fluorinated groups on the transesterification reaction rate.
Barbier Hyperbranching Polymerization‐Induced Emission from an AB‐Type Monomer
Authors: Sheng Yu‐Jing , Su Min , Xiao Hang , Shi Quan‐Xi , Sun Xiao‐Li , Zhang Ruliang , Bao Hongli , Wan Wen‐Ming 
Published: June 2022

AbstractLuminescent polymer materials have gained considerable research efforts in the past decades and are generally molecular designed by extending the π system of the polymer main chain or by incorporating chromophores into the polymer chain, which suffer from poor solubility, difficult synthesis, or multi‐step procedures. Meanwhile, according to the step‐growth polymerization theory, synthesis of hyperbranched polymers from an AB‐type monomer is still challenging. Herein, we report a one‐pot synthesis of nonconjugated luminescent hyperbranched polymer material via Barbier hyperbranching polymerization‐induced emission (PIE) from an AB‐type monomer. The key step in the realization of the hyperbranched polymer is bi‐functionalization of a mono‐functional group. Through a Barbier reaction between an organohalide and an ester group in one pot, bi‐functionalization of mono‐functional ester is realized through two‐step nucleophilic additions, resulting in hyperbranched polytriphenylmethanols (HPTPM). Attributed to through‐space conjugation and inter‐ and intramolecular charge‐transfer effects induced by polymer chain, nonconjugated HPTPMs are PIEgens, which are tunable by monomer structure and polymerization time. When all phenyl groups are rotatable, HPTPM is aggregation‐induced emission type PIEgen. Whereas, it is aggregation‐caused quenching type PIEgen if some phenyl groups are rotation forbidden. Further potential applications of PIEgen are in the fields of explosive detection and artificial light harvesting systems. This work, therefore, expands the monomer library and molecular design library of hyperbranched polymers through “bi‐functionalization of mono‐functional group” strategy, which eventually expands the preparation library of nonconjugated luminescent polymer materials through one‐pot PIE from nonemissive monomer.
Optically active polyimides with different thermal histories of their preparation
Authors: Sysel Petr , Hovorka Štěpán , Kohout Michal , Holakovský Roman , Žádný Jaroslav , Čížek Jan , Izák Pavel 
Published: June 2022

AbstractOptically active linear polyimides and hyperbranched poly (amic acid–imide) were prepared by using procedures varying in particular in the maximum temperature employed in their synthesis. The two types of linear polyimides were based on 4,4′‐(hexafluoroisopropylidene)diphthalic anhydride and 1,2‐diaminocylohexane enantiomers or 4,4′‐(hexafluoroisopropylidene)diphthalic anhydride and 2,2′‐diamino‐1,1′‐binaphthalene enantiomers. The amine‐terminated hyperbranched poly (amic acid–imide) was prepared from 4,4′‐(hexafluoroisopropylidene)diphthalic anhydride and 4,4′,4″‐triaminotriphenylmethane, and its end groups were modified with the chiral selectorsN‐acetyl‐D‐phenylalanine orN‐acetyl‐L‐phenylalanine. The final structure of the products was analyzed by IR spectroscopy, and their optical activity was evaluated and confirmed by polarimetry or circular dichroism.