bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE ROLE OF RED GINGER AND WARM WATER IN RELIEVING LABOR PAIN
Authors: MINTARSIH WIWIN , ROHMATIN ETIN , SAHLAN MUHAMAD 
Published: July 2022

Objective: The purpose of this study was to compare the efficacy of red ginger and warm water in relieving labor pain at the first stage of the active phase by applying two methods of administration, which were drinking and compressing.
Methods: Two-group pre-test-the post-test design was conducted, and 60 respondents were chosen by using purposive sampling. The respondents were divided into four groups consisting of 15 respondents each. Each group was given a different intervention. The interventions were red ginger tea consumption (group A), warm water consumption (group B), red ginger compress (group C), or warm water compress (group D). The data analysis was done by univariate and bivariate analysis through Wilcoxon and Mann Whitney tests.
Results: Based on olaboristical analysis, the Mann Whitney (Z) value was-4.261 and-3.240 with a p-value equal to 0.000 and 0.001 for the drinking and compress method, respectively. This indicated that there was a significantly different effect of red ginger and warm water on the labor pain reduction at the first stage of the active phase. Furthermore, comparing the two methods, the greater Z value of red ginger tea consumption was found in comparison to the Z value of red ginger compress.
Conclusion: Red ginger tea consumption was more effective compared to red ginger compress in reducing the labor pain at the first stage of the active phase.
SECOND DEGREE BURN WOUND HEALING ACTIVITY TEST OF ETHANOL EXTRACT MAHOGANY BARK (SWIETENIA MAHAGONI (L.) JACQ.)
Authors: AGUSTIARINI VITRI , FITRYA  , AMRIANI ANNISA , ZERLI ROHMA SYAKTIFIANI 
Published: July 2022

Objective: This research aims to determine the characteristics and activity of an ethanolic extract of mahogany bark on the healing rate of second-degree burns.
Methods: The animal test consisted of 25 white male rats of the Sprague Dawley strain divided into five groups. The positive group was treated by Lanakeloid-E®cream, negative group, and treatment groups with varying dosages (100, 200, and 400 mg/Kg Bodyweight). The parameters observed included the time formed, the scab’s shedding time, and the percentage of wound healing. Burn area data were analyzed using the one-way ANOVA test to see if there were differences in the percentage of burns healing between groups.
Results: The results showed that ethanol extract of mahogany bark (Swietenia mahagoni (L.) Jacq.) at a dose of 400 mg/Kg Bodyweightwas the best dose for accelerating burn healing with a recovery rate of 85,706% during 14 d. Statistical test results on the percentage of burn injury between negative and positive controls and the test groups had significantly different results (p<0,05).
Conclusion: This study concludes that presenting the ethanol extract of mahogany bark (Swietenia mahagoni (L.) Jacq) at a dose of 400 mg/Kg Bodyweight shows the best second-degree burns healing.
CHARACTERIZATION OF NANOPARTICLES CONDITIONED MEDIUM ADIPOSE TISSUE MESENCHYMAL STEM CELL (CM-ATMSC)
Authors: RAHMAT DENI , WIDOWATI WAHYU , FARIED AHMAD , NAINGGOLAN ITA MARGARETHA , PRIYANDOKO DIDIK , BUDIATI ANARISA , ZAKARIA TEDDY MARCUS , AFIFAH ERVI 
Published: July 2022

Objective: The aims of this study were to formulate and characterize the nanoparticles containing conditioned medium adipose tissue
mesenchymal stem cell (CM-ATMSC).
Methods: Adipose Tissue Mesenchymal Stem Cell (AT-MSC) was cultured with supplemented Modified Eagle Medium (MEM) Alpha in an incubator with 37 °C and 5% CO2. The conditioned medium was collected when the cells were confluent. Nanoparticles were characterized in the term of morphology using transmission electron microscopy (TEM), particle size, zeta potential, loading capacity, entrapment efficiency, and drug release.
Results: CM-ATMSC nanoparticles had the smallest particle size, namely chitosan-inulin nanoparticles with particle size of 128 nm, and the largest particle was modified chitosan (thiomer)-fucoidan nanoparticles with particle size of 254.3 nm. Based on zeta potential results, it is known that the resulting nanoparticle suspension was stable.
Conclusion: The resulting nanoparticle suspension was stable and the smallest CM-ATMSC nanoparticle demonstrated the particle size of 128 nm. The results showed that the nanoparticles of CM-ATMSC have been successfully prepared.
IN SILICO PREDICTION OF ESSENTIALS OIL FROM CYMBOPOGON NARDUS AS IMMUNOMODULATOR IN RHEUMATOID ARTHRITIS
Authors: SLAMET HERYANTO , MUMPUNI ESTI , KUMALA SHIRLY , YANTIH NOVI , NAFISA SAFIRA , AULENA DESI NADYA , SUMIYATI YATI 
Published: July 2022

Objective: Rheumatoid arthritis (RA) is an autoimmune disease involving the synovial lining of the major joints. Our study involves bioactive compounds of Cymbopogon Nardus as possible Rheumatoid arthritis drugs in silico targeted TNF-α, JAK1/2, JAK3, PAD4, and DHFR.
Methods: Using computational docking and receptors from the Protein Data Bank (PDB) files 2AZ5, 3EYG, 3LXY, 1DLS, and 1WDA. Molegro Virtual Docker 6.0 was utilized to undertake an in silico anti-arthritis drugs study. ChemDraw 3D was utilized to minimize the ligand's energy before docking, and the structures Native Ligand were employed as positive control medications. A pharmacokinetic and toxicological study was performed using SwissADME (ADME) and PK-CMS.
Results: Using the Moldock SE mechanism calculates the binding (atom) energies of each protein (Enzyme) and each ligand at the least energetic conformation state. Docking results of ten tested bioactive compounds have not displayed the Lowest rerank score scores and best fit within the prominent active site residues.
Conclusion: The Essentials oils from Cymbopogon nardus have not effectively suppressed the Rheumatoid Arthritis pathway through inhibition of TNF-α, JAK1/2, JAK3, PAD4, and DHFR which can serve as potential lead compounds for the development of new drugs for the treatment of Rheumatoid Arthritis.
MOLECULAR DOCKING OF CYMBOPOGON NARDUS (L.) RENDLE COMPOUNDS AS A PROTEASE INHIBITOR OF SARS-COV-2
Authors: RIFALDI FAJRI , MUMPUNI ESTI , KUMALA SHIRLY , YANTIH NOVI , AULENA DESI NADYA , NAFISA SAFIRA 
Published: July 2022

Objective: The study aimed to obtain active compounds from Cymbopogon nardus as candidates for protease inhibitor of SARS-CoV-2 virus by assessing the ligand-binding affinity in the binding pocket of SARS-CoV-2 main protease protein.
Methods: Molecular docking as a protease inhibitor of SARS-CoV-2 was carried using computational software Molegro Virtual Docker (MVD); computational docking was carried using receptors with Protein Data Bank (PDB) were also used to compare the affinity strength of the test compounds against the protease receptor (code of 5R81). The compounds of Cymbopogon nardus were optimized before docking using ChemDraw and minimized energy using Chem3D. Visualization of the docking result by using Discovery Studio and pkCSM was utilized to perform a pharmacokinetic and toxicological analysis (ADMET).
Results: The result showed geranyl acetate, elemol, citronellal, and citronellyl acetate compounds from Cymbopogon nardus has a rerank score more negative than native ligand from 5R81 receptor as a protease inhibitor of SARS-CoV-2.
Conclusion: Cymbopogon nardus can be developed as an antivirus with the mechanism of a protease inhibitor of SARS-CoV-2 candidates after further experimental tests.
PROPOLIS AS AN ALTERNATIVE TO INCREASE HEMOGLOBIN LEVELS IN ANEMIC ADOLESCENT GIRLS
Authors: ROHMATIN ETIN , KRISJAYANTI NOVI , YULIASTUTI SANTI , MINTARSIH WIWIN , SAHLAN MUHAMAD 
Published: July 2022

Objective: The purpose of this study was to analyze the effectiveness of Tetragonula sapiens propolis collected from North Luwu, Sulawesi, Indonesia to treat anemia in adolescent girls.
Methods: A quasi-experimental design with a two-group pre-test—the post-test design was applied, and 44 respondents were chosen by using purposive sampling. The respondents were divided into two groups. Each group was given iron supplement every day. For the intervention group, the respondents consumed 5 drops of propolis for three times a day. Meanwhile, for the control group, IPI vitamin C was given instead of propolis. The intervention was given for 30 d in a row. The hemoglobin (Hb) level measurement was conducted after 30 d.
Results: The results showed that the Hb levels of the intervention group were higher compared to the control group after propolis was given for 30 d. The result of the analysis showed a significant value of (2-tailed) 0.000<0.05.
Conclusion: Tetragonula sapiens propolis could be used to increase the Hb levels in anemic adolescent girl.
COMPREHENSIVE MOLECULAR STUDY REVEALS THE POTENTIAL ROLE OF CHEBULINIC ACID AND BOERAVINONE B TO ESTABLISH REDOX HOMEOSTASIS IN METABOLICALLY STRESSED CELLS
Authors: BOTE HARSHAD K. , KAKADE SAMIDHA S. , BIRADAR SHIVTEJ P. , KHANDARE RAHUL V. , PAWAR PANKAJ K. 
Published: July 2022

Objective: Our objective was to assess the multi-dimensional protective mechanism of Chebulinic acid (CA) and Boeravinone B (BB) against MG-induced metabolic stress and cytotoxicity.
Methods: In this study, we have studied CA-and BB-mediated changes in molecular markers of highly dynamic mechanisms of mitochondrial disintegration, nuclear damage and cell death pathways associated with early ageing in MG-exposed Saccharomyces cerevisiae cells using biochemical assays, qRT-PCR and flow cytometry.
Results: We found that CA and BB interventions during MG-induced stress in S. cerevisiae reduce the rate of extracellular nitrite production, protein carbonyl content, lipid peroxidation and in addition, photo components positively modulate the expression patterns of genes involved in different cell death pathways. Furthermore, CA and BB treatments to MG-stressed cells reduced the number of cells in late apoptosis by 13.4% and 28.3%, respectively. On top of that, CA and BB supplementation during MG-stress restored mitochondrial membrane potential (ΔΨm) by 63.0% and 62.5%, respectively.
Conclusion: Based on the results of this study, it seems CA and BB phytotherapy protect against MG-induced cytotoxicity through their natural antioxidant properties by establishing redox homeostasis; thus, CA and BB defend the cell components from oxidative damage of different biomolecules and organelles, ultimately increase longevity.
PENDAMPINGAN ANAK KORBAN PERUNDUNGAN PERSPEKTIF TAFSIR Al-QUR’AN SURAT AL-HUJURAT AYAT 11 DAN HAK ASASI MANUSIA
Authors: Haris Ahmad Faishal , Cholil Mufidah , Isroqunnajah Isroqunnajah 
Published: July 2022

Abstract: This article is related to guaranteeing the rights of every child from rampant bullying cases that occur in society. Children are very difficult to speak out against what they receive, because they are limited in terms of knowledge of the law and moreover they are in the grip of adults. Children who are victims of acts of violence will become perpetrators of violence themselves when they are adults if they are not accompanied or handled optimally. Although prohibition of bullying or violence has been explained and affirmed in the Qur'an or Human Rights Act, in reality there are still many cases of Peru or violence. This article aims as additional knowledge for the community to provide more assistance to children and can avoid bullying. In Surah Al-Hujurat verse 11, it is clearly explained that Allah Swt expressly forbids his actions to do wrong to others by criticizing or obliging his dignity. Human rights analysis Bullying against children is a disgraceful act that can eliminate a person's rights, because in Article 28b paragraph (2) of the 1945 Constitution, it is emphasized that every child has the right to live, grow and develop and is entitled to protection from violence and discrimination.Keywords: Accompaniment; Child Victim of Bullying; Interpretation; Human Rights.Abstrak: Artikel ini mendiskusikan terkait dengan jaminan atas hak-hak setiap anak dari maraknya kasus perundungan yang terjadi di masyarakat. Anak-anak sangat susah untuk bersuara menggugat apa yang mereka terima, hal tersebut dikarenakan mereka terbatas dalam hal pengetahuan terhadap hukum dan mereka berada dalam cengkraman orang dewasa. Anak yang menjadi korban tindak kekerasan akan menjadi pelaku kekerasan itu sendiri ketika sudah dewasa jika tanpa ada pendampingan atau penanganan secara maksimal. Meski larangan perundungan atau kekerasan telah banyak dijelaskan dan ditegaskan dalam Al-Qur’an ataupun dalam Undang-Undang Hak Asasi Manusia, namun dalam realitanya kasus perundungan atau kekerasan masih banyak terjadi. Artikel ini bertujuan sebagai tambahan pengetahuan bagi masyarakat agar memberikan pendampingan lebih kepada anak dan bisa menghindari sikap perundungan kepada anak. Pada surat Al-Hujurat ayat 11 dengan tegas dijelaskan bahwa Allah Swt secara tegas melarang makhluknya untuk berbuat dzolim kepada yang lain dengan mencela maupun merendahkan harkat dan martabatnya. Berdasarkan analisis HAM perundungan terhadap anak merupakan perbuatan tercela yang dapat menghilangkan hak-hak seseorang, karena dalam pasal 28b ayat (2) UUD 1945, ditegaskan bahwa setiap anak berhak atas kelangsungan hidup, tumbuh, dan berkembang dan berhak atas perlindungan dari kekerasan maupun diskriminasi.Kata Kunci: Pendampingan; Anak Korban Perundungan; Tafsir; Hak Asasi Manusia.
DAKWAH TRANSFORMATIF MELALUI FILANTROPI: FILANTROPI ISLAM DALAM MENGENTAS KEMISKINAN DAN KETIDAKADILAN
Authors: Abrori Abrori , Kharis Ahmad 
Published: July 2022

Abstract: The condition of poverty and injustice that is felt, especially Muslims, will cause sustainable problems, it needs strategic and relevant efforts to unravel the deterioration through da'wah activities. That preaching is not just to spread religion and call for truth. Rather it's about how we can see what we can do for our surroundings. This study aims to know and analyze the potential, role and opportunities of Islamic philanthropy to alleviate poverty and injustice. This type of research is qualitative using descriptive-analytical approach. Data obtained from extracting information through interviews, observations and documentation. The results of the study explained that open transformative da'wah on the problems of poverty and injustice that occur in the community needs to be parsed through Islamic Da'wah. Islamic philanthropy is a manifestation of our love and care as fellow human beings elevates ethical values. The agenda of Islamic Da'wah through zakat, infaq, Sadaqah, and waqaf should be able to parse domestic issues. Effective communication channels, propaganda delivered on target, as well as support from government institutions and institutions, the implementation of Islamic philanthropy relies on solutions to address the problems of poverty and injustice in Indonesia.Keywords: Transformative Da'wah; Injustice; Poverty; Islamic Philanthropy. Abstrak: Kondisi kemiskinan dan ketidakadilan yang dirasakan khususnya umat Islam akan menimbulkan problematika berkelanjutan, maka perlu upaya strategis dan relevan mengurai keterpurukan melalui aktivitas dakwah. Bahwa dakwah bukan sekedar untuk menyebarkan agama dan menyerukan kebenaran. Melainkan dakwah itu tentang bagaimana kita dapat melihat apa yang bisa kita lakukan untuk sekitar kita. Penelitian ini bertujuan mengetahui dan menganalisis potensi, peran dan peluang filantropi Islam mengentaskan kemiskinan dan ketidakadilan. Jenis penelitian ini adalah kualitatif menggunakan pendekatan deskriptif-analitis. Data diperoleh dari penggalian informasi melalui wawancara, observasi dan dokumentasi. Hasil penelitian menjelaskan dakwah transformatif yang terbuka mengenai permasalahan kemiskinan dan ketidakadilan yang terjadi di masyarakat perlu diurai melalui dakwah Islam. Filantropi Islam merupakan wujud cinta dan peduli kita sebagai sesama manusia mengangkat nilai etis. Agenda dakwah Islam melalui zakat, infaq, shadaqah, dan waqaf hendaknya mampu mengurai persoalan domestik. Saluran komunikasi yang terjalin dengan efektif, dakwah yang disampaikan tepat sasaran, serta dukungan dari lembaga dan institusi pemerintahan, implementasi filantropi Islam menyandarkan pada solusi untuk menangani masalah kemiskinan dan ketidakadilan di Indonesia.Kata Kunci: Dakwah Transformatif; Ketidakadilan; Kemiskinan; Filantropi Islam.
The Construction of Religious Freedom in Indonesian Legislation: A Perspective of Maqāṣid Ḥifẓ Al-Dīn
Authors: Lathifah Anthin , Hapsin Abu - , Rofiq Ahmad , Hidayatullah M. Arief 
Published: July 2022

The Indonesian state has legal provisions of religious freedom contained in the constitution and its derivatives legislation. This article aims to discuss religious freedom in Indonesian legislation from the perspective of maqāṣid hifẓ al-dīn. This study is the result of qualitative research using a content analysis approach. From the results of the discussion, it is known that the freedom of religion in Indonesian legislation includes freedoms to choose belief (Belief in One Supreme God), to worship, and to express religion. These provisions are in line with hurriyyah al-'i'tiqād Ibn 'Āsyūr and al-ḥurriyyah fī al-dīn al-Zuhailī regarding freedom of worship but are not in accordance with al-Zuhaili's opinion about freedom of belief, an area of personal choice when one may choose to be religious or not. The contradiction occurs because all Indonesian citizens must believe in One and Only God as the first precept of Pancasila and make six religions as religions recognized by the State as contained in Presidential Decree No. 1/1965 (PNPS Act). Therefore, it is necessary to reconstruct the law and values of religious freedom contained in the PNPS Act, especially in its implementation.
Bapalas as Alternative Dispute Resolution of Fighting on Muslim Dayak Community in Muara Teweh, Central Kalimantan
Authors: Helim Abdul , Ahmad Sabarudin , Padlianor Padlianor 
Published: July 2022

This study discusses the tendency of the Muara Teweh Muslim Dayak community, who prefers bapalas in resolving fighting disputes over other legal remedies. Bapalas is a traditional dispute resolution of fights with the help of mantir and community leaders and is attended by the families of both parties. In the Dayak community, there are various bapalas, such as midwives bapalas, marriages bapalas, births bapalas, death bapalas, and fights bapalas. This research focuses on studying the fight bapalas as an alternative dispute resolution for fights in the community. Fighting is part of criminal law, usually resolved through litigation by repressive settlements. However, it is different in the Muslim Dayak community in Muara Teweh. They prefer to settle the dispute through this bapalas tradition. The research was conducted using empirical legal research methods using an Islamic law approach. The theory used is the theory of ‘urf and the concept of iṣlāḥ in Islam. The study result indicates that the Muslim Dayak community in Muara Teweh prefers this settlement because, first, it has become customary law that has been passed for generations. Second, bapalas minimize the grudges between the conflicting parties. Third, compared to other resolutions, primarily through litigation, bapalas are much easier dan more effective in resolving conflicts, especially in terms of time. This dispute resolution model aligns with Islamic law according to 'urf and the concept of Islam.‘Urf can be a source of law as long as it does not conflict with sharia and is in line with the sadd al-żarī‘ah method, which means if the customs in society can prevent or block the harm, then it is allowed. It is also in line with the concept of iṣlāḥ that bapalas is a conflict resolution method that can eliminate and stop hostility and conflict between humans.
Punishment for Zina Muḥṣān Offenders in Aceh Qanun No. 6 of 2014 in the Perspective of Fiqh al-Siyāsah
Authors: Fahmi Mutiara , Hasan Nurhayati Ali , Usman Iskandar , Abdullah Amiruddin , Hanafiyah Muhibuddin 
Published: July 2022

This paper attempts to answer the issue of punishment for zina muḥṣān offenders in Aceh Qanun No. 6 of 2014 from the perspective of fiqh al-siyāsah and the ways the law is implemented in closed spaces such as prisons per the Governor Regulation No. 5 of the 2018. This study is a legal study with a Islamic politic approach (fiqh al-siyāsah) with a literature study data collection method. The polemic of the implementation of the Qanun Jinayah (criminal regional bylaws) in Aceh not only receives attention from outside such as human rights and non-governmental organization activists, but also from among Islamic academics or Acehnese ulemas. One of the most discussed topics is related to ‘uqūbah (punishment) for fornicators that does not distinguish between muḥṣān (married) and ghayr muḥṣān (unmarried) fornicators as is the case in classical fiqh (Islamic jurisprudence) literature. Qanun Jinayah does not at all separate between muḥṣān and ghayr muḥṣān fornicators, unlike the provisions of Islamic law which prescribe a hundred lashes for ghayr muḥṣān fornicators and stoning to death for muḥṣān fornicators. This indicates that those who commit zina in Aceh, whether married or unmarried, are punished with the same severity, which is 100 (one hundred) lashes. Further, the issue of changing the place of the flogging execution from public to prison in accordance with Aceh Governor Regulation No. 5 of 2018 concerning the implementation of the jināyah (criminal) procedural law is also worth to study from the point of view of fiqh al-siyāsah (Islamic politics) and legislation.
Men and Women in The Distribution of Inheritance in Mandar, West Sulawesi, Indonesia
Authors: Rahman Ulfiani , Idham Idham , Dalif M. , Makmur Makmur , Sewang Anwar 
Published: July 2022

In general, there are two patterns of inheritance distribution in Indonesia, based on Islamic and customary inheritance laws. This research specifically focused on the distribution of inheritance for men and women in Mandar by scoping the research area in Polewali Mandar Regency, West Sulawesi Province. This research is an empirical legal study using the sociology of law approach. Data collection techniques were obtained through literature study and interviews. The results showed that the Mandar people who lived in Polewali Mandar, West Sulawesi Province, considered that whether son or daughter earned the same sharing, there was no difference. The view that puts the same position between the two has influenced the legal treatment of inheritance. The distribution of inheritance in Mandar, especially for sons and daughters, was found in two patterns, namely, using Islamic inheritance patterns and customary inheritance patterns. This customary inheritance pattern is practiced in the form that they are no longer able to define, whether it is in the form of Islamic law or customary law, dividing the inheritance to their children to be managed by themselves, and some have shared the inheritance with their children, but the heir still manages the assets, and the house of the parents belongs to the youngest child, without distinguishing between the youngest son or the youngest daughter.