bluuebunny/crossref_metadata_2025_split huggingface dataset:
Central Nervous System Fungal Infections in Children With Leukemia and Undergoing Hematopoietic Stem Cell Transplantation: A Retrospective Multicenter Study
Authors: Karaman Serap , Kebudi Rejin , Kizilocak Hande , Karakas Zeynep , Demirag Bengu , Evim Melike S. , Yarali Nese , Kaya Zuhre , Karagun Barbaros S. , Aydogdu Selime , Caliskan Umran , Ayhan Aylin C. , Bahadir Aysenur , Cakir Betul , Guner Burcak T. , Albayrak Canan , Karapinar Deniz Y. , Kazanci Elif G. , Unal Ekrem , Turkkan Emine , Akici Ferhan , Bor Ozcan , Vural Sema , Yilmaz Sebnem , Apak Hilmi , Baytan Birol , Tahta Neryal M. , Güzelkucuk Zeliha , Kocak Ulker , Antmen Bulent , Tokgöz Huseyin , Fisgin Tunc , Özdemir Nihal , Gunes Adalet M. , Vergin Canan , Unuvar Aysegul , Ozbek Namik , Tugcu Deniz , Bay Sema B. , Tanyildiz Hikmet G. , Celkan Tiraje 
Published: August 2022

Background:
Central nervous system fungal infections (CNSFI) are seen in patients with hematologic malignancies and have high morbidity and mortality. Because of their rarity, there is limited data on CNSFI in children with no established treatment protocols or guidelines.

Materials and Methods:
In this multicenter retrospective study, 51 pediatric patients with leukemia, 6 of whom had undergone bone marrow transplantation, with proven or probable CNSFI were evaluated. Fungal infections were defined as proven or probable based on European Organisation for Research and Treatment of Cancer criteria. Proven CNSFI was diagnosed by appropriate central nervous system (CNS) imaging or tissue sample findings in combination with positive microbiological results of cerebrospinal fluid. A positive culture, microscopic evidence of hyphae, a positive result of the galactomannan assays are defined as positive microbiological evidence. Probable CNSFI was defined as appropriate CNS imaging findings together with proven or probable invasive fungal infections at another focus without CNS when there is no other explanatory condition. Data was collected by using the questionnaire form (Supplemental Digital Content 1, http://links.lww.com/JPHO/A541).

Results:
Seventeen patients had proven, 34 patients had probable CNSFI. Headaches and seizures were the most common clinical findings. The median time between the onset of fever and diagnosis was 5 days. The most common fungal agent identified was Aspergillus. Sixteen patients received single-agent, 35 received combination antifungal therapy. Surgery was performed in 23 patients. Twenty-two patients (43%) died, 29 of the CNSFI episodes recovered with a 20% neurological sequelae.

Conclusion:
CNSFIs should be considered in the differential diagnosis in patients with leukemia and refractory/recurrent fever, headache, neurologicalocular symptoms, and a radiologic-serological evaluation should be performed immediately. Early diagnosis and prompt management, both medical and surgical, are essential for improving clinical outcomes.
Prosthesis use among individuals with lower limb amputation in Bangladesh
Authors: Al Imam Mahmudul Hassan , Kader Manzur , Islam Rangila , Alamgir Hasnat 
Published: August 2022

Objective:
This study aimed to assess factors related to prostheses use among individuals with lower limb amputation in Bangladesh.

Methods:
Data related to prosthesis use, functional capabilities (as measured with the Locomotor Capabilities Index [LCI]), and user satisfaction were collected using telephone interviews between January 2014 and October 2016. Descriptive and regression analyses were performed.

Results:
This study involved 183 participants (89.6% male); the mean (SD) age was 49.5 (10.7) years. Most of the participants (95.6%) used prostheses daily, and the mean (SD) duration of use was 7.0 (4.1) hours per day. The mean (SD) basic LCI score, advanced LCI score, and total LCI score were 25.1 (4.9), 20.8 (8.3), and 45.9 (12.2), respectively. Among them, 36.7% were dissatisfied with the weight of the prosthesis. Having a below knee amputation (odds ratio 2.6 and confidence interval 1.3, 5.3) and absence of comorbidities (odds ratio 2.1; confidence interval 1.0, 4.4) were associated significantly with an increased use of prosthesis.

Conclusion:
Factors such as weight of the prosthesis, amputation level, and presence of comorbidities are important considerations while planning for prosthetic rehabilitation and optimize utilization of the prosthetic devices.
Analysis of Risk Factors for Vulnerable Plaque Formation and Pathogenic in Carotid Artery
Authors: Bao Jingang , Tong Xiaoguang , Wu Rile , Yun Qiang 
Published: August 2022

Objectives:
The formation of vulnerable carotid artery plaque may be closely related to a single factor or caused by multiple factors. This paper discusses the pathogenic risk factors for vulnerable plaque in patients with severe internal carotid artery (ICA) stenosis who received endarterectomy through regression analysis.

Materials and Methods:
A total of 98 patients with a complete clinical and laboratory assessment underwent carotid endarterectomy. Metabolic syndrome (MetS) and MetS components, ICA plaque thickness and ICA peak systolic velocity, previous ischemic stroke or transient ischemic attack (TIA), and other risk factors were included in the pathogenic risk factor for vulnerable plaque. Univariate logistic regression analysis was used to determine vulnerable carotid plaque risk factors. If P<0.2, it was considered potential confounders. Binary logistic regression model was controlled for potential confounders.

Results:
Among the 98 patients, stable carotid plaques 38 (39%) and unstable carotid plaques 60 (61%), male 76 (77.6%) and female 22 (22.4%), and Han Chinese 68 (68.4%) and Mongols 30 (30.6%). Univariate logistic regression to P<0.2 has 6 risk factors, which are previous ischemic stroke or TIA, ICA peak systolic velocity, ICA plaque thickness, body mass index, total cholesterol, and alcohol consumption. The significant result of the binary logistic regression analysis was the previous ischemic stroke or TIA (OR=4.52; 95% CI, 1.67–12.09), P=0.003 and ICA peak systolic velocity (OR=1.01; 95% CI, 1.00–1.02), P=0.014.

Conclusions:
The patients with previous ischemic stroke or TIA and higher ICA peak systolic velocity are associated with vulnerable plaque pathogenic features. There is no obligatory association between MetS and formation of carotid plaque vulnerability.
Olfactory Dysfunction and its Course in Patients With Nasal Bone Fracture
Authors: Yoon Sihyun , Kim Youngjun 
Published: August 2022

Purpose:
Nasal bone fractures are the most common facial bone fractures. Although olfactory dysfunction is one of the most common complications in patients with nasal bone fractures, few studies on olfactory dysfunction in nasal bone fractures have been reported. The authors attempted to find the frequency and course of olfactory dysfunction and hypothesize its mechanism in patients with nasal bone fractures.

Methods:
Sixty-six patients who underwent closed reduction were examined using the Korean version of Sniffin’ Sticks test (KVSS) II at preoperation, 1 month and 6 months postoperation. We categorized 30 points or more as “normosmia,” 15 points or less as “anosmia,” and the scores between them as “hyposmia.” The authors only performed test in patients who subjectively complained of their loss of sense of smell at 1 and 6 months postoperation.

Results:
The authors classified the patients as “olfactory dysfunction” or “normal olfaction” using the Threshold-Discrimination-Identification score and subjective complaint of symptom. Olfactory dysfunction was seen on 31 of 66 patients (46.9%) preoperatively. Twenty-four patients (36.3%) showed olfactory dysfunction at 1 month postoperation, and 4 patients (6.0%) showed olfactory dysfunction at 6 months postoperation. Twelve of the 35 patients (34.3%) with normosmia shown in the preoperation had new olfactory dysfunction after the surgery.

Conclusion:
Olfactory dysfunction is common complication in nasal bone fracture. However, this complication was recovered in most cases (93.9%). In addition, patients should receive explanations about the possibility of iatrogenic olfactory impairment after surgery, and a gentle maneuver is helpful for preventing iatrogenic damage.
Localized bulging of an inflated rubber tube with fixed ends
Authors: Guo Zhiming , Wang Shibin , Fu Yibin 
Published: August 2022

When a rubber tube with free ends is inflated under volume control, the pressure will first reach a maximum and then decrease monotonically to approach a constant asymptote. The pressure maximum corresponds to the initiation of a localized bulge and is predicted by a bifurcation condition, whereas the asymptote is the Maxwell pressure corresponding to a ‘two-phase’ propagation state. By contrast, when the tube is first pre-stretched and then has its ends fixed during subsequent inflation, the pressure as a function of the bulge amplitude has both a maximum and a minimum, and the behaviour on the right ascending branch has previously not been fully understood. We show that for all values of the pre-stretch and tube length, the ascending branches all converge to a single curve that is dependent only on the ratio of the tube thickness to the outer radius. This curve represents the Maxwell state to be approached in each case (if Euler buckling or axisymmetric wrinkling does not occur first), but this state is pressure-dependent, in contrast to the free-ends case. We also demonstrate experimentally that localized bulging cannot occur when the pre-stretch is sufficiently large and investigate what strain-energy functions can predict this observed phenomenon.
This article is part of the theme issue ‘The Ogden model of rubber mechanics: Fifty years of impact on nonlinear elasticity’.
A mathematical model for the auxetic response of liquid crystal elastomers
Authors: Mihai L. Angela , Mistry Devesh , Raistrick Thomas , Gleeson Helen F. , Goriely Alain 
Published: August 2022

We develop a mathematical model that builds on the surprising nonlinear mechanical response observed in recent experiments on nematic liquid crystal elastomers. Namely, under uniaxial tensile loads, the material, rather than thinning in the perpendicular directions, becomes thicker in one direction for a sufficiently large strain, while its volume remains unchanged. Motivated by this unusual large-strain auxetic behaviour, we model the material using an Ogden-type strain-energy function and calibrate its parameters to available datasets. We show that Ogden strain-energy functions are particularly suitable for modelling nematic elastomers because of their mathematical simplicity and their clear formulation in terms of the principal stretches, which have a direct kinematic interpretation.This article is part of the theme issue ‘The Ogden model of rubber mechanics: Fifty years of impact on nonlinear elasticity’.
The Ogden and the extended tube model as backbone in describing electroactive polymers: advancements in modelling nonlinear behaviour and fracture
Authors: Kaliske M. , Storm J. , Kanan A. , Klausler W. 
Published: August 2022

Hyperelastic constitutive relations form the basis of advanced models for novel materials. Such elastic deformation potentials are the backbone for complex material formulations at elastic and inelastic deformations, especially when embedded into powerful frameworks like generalized standard materials, as well as multiphysical and multiscale formulations. With the focus on electroactive polymers, the article at hand demonstrates the derivation of a variational, rate-dependent electromechanical model for quasi-incompressible polymers and the derivation of an electromechanical model for regularized fracture mechanics by means of the phase-field method. Starting at the prominent Ogden and the extended tube model, some developments from the last decades are revisited and presented via the principle of virtual power, for instance, the established mixed element formulation, nonlinear viscoelasticity and electromechanical coupling. An electromechanically fully coupled representative crack element is used to derive a novel phase-field model for fracture. A key property of the proposed model is the ability to describe the electrical free-space behaviour inside the crack gap, which is demonstrated by adopting three common crack-face conditions.This article is part of the theme issue ‘The Ogden model of rubber mechanics: Fifty years of impact on nonlinear elasticity’.
The Ogden model of rubber mechanics: 50 years of impact on nonlinear elasticity
Authors: Destrade Michel , Dorfmann Luis , Saccomandi Giuseppe 
Published: August 2022

We place the Ogden model of rubber elasticity, published inProceedings of the Royal Society50 years ago, in the wider context of the theory of nonlinear elasticity. We then follow with a short interview of Ray Ogden FRS and introduce the papers collected for this Theme Issue.This article is part of the theme issue ‘The Ogden model of rubber mechanics: Fifty years of impact on nonlinear elasticity’.
Linking neuronal and hemodynamic network signatures in the resting human brain
Authors: Elshahabi Adham , Ethofer Silke , Lerche Holger , van de Velden Daniel , Wehrl Hans , la Fougère Christian , Braun Christoph , Focke Niels K. 
Published: August 2022

AbstractDespite several studies investigating the relationship between blood-oxygen-level-dependent functional MRI (BOLD-fMRI) and neuroelectric activity, our understanding is rather incomplete. For instance, the canonical hemodynamic response function (HRF) is commonly used, regardless of brain region, frequency of electric activity and functional networks. We studied this relationship between BOLD-fMRI and electroencephalography (EEG) signal of the human brain in detail using simultaneous fMRI and EEG in healthy awake human subjects at rest. Signals from EEG sensors were filtered into different frequency bands and reconstructed it in the three-dimensional source space. The correlation of the time courses of the two modalities were quantified on a voxel-by-voxel basis on full-brain level as well as separately for each resting state network, with different temporal shifts and EEG frequency bands. We found highly significant correlations between the BOLD-fMRI signal and simultaneously measured EEG, yet with varying time-lags for different frequency bands and different resting state networks. Additionally, we found significant negative correlations with a much longer delay in the fMRI BOLD signal. The positive correlations were mostly around 6-8 seconds delayed in the BOLD time course while the negative correlations were noticed with a BOLD delay of around 20 to 26 seconds. These positive and negative correlation patterns included the commonly reported alpha and gamma bands but also extend in other frequency bands giving characteristic profiles for different resting state networks. Our results confirm recent works that suggest that the relationship between the two modalities is rather brain region / network-specific than a global function and suggest that applying a global canonical HRF for electrophysiological data is probably insufficient to account for the different spatial and temporal dynamics of different brain networks. Moreover, our results suggest that the HRF also varies in different frequency bands giving way to further studies investigating cross-frequency coupling and its interplay with resting state networks.
Inflammation-induced mitochondrial and metabolic disturbances in sensory neurons control the switch from acute to chronic pain
Authors: Willemen Hanneke L.D.M. , Ribeiro Patrícia Silva Santos , Broeks Melissa , Meijer Nils , Versteeg Sabine , Małecki Jędrzej , Falnes Pål Ø. , Jans Judith , Eijkelkamp Niels 
Published: August 2022

AbstractPain often persists in patients with inflammatory diseases, even when the inflammation has subsided. The molecular mechanisms leading to this failure in resolution of inflammatory pain and the transition to chronic pain are poorly understood. Mitochondrial dysfunction in sensory neurons has been linked to chronic pain, but its role in resolution of inflammatory pain is unclear.Transient inflammation causes neuronal plasticity, called hyperalgesic priming, which impairs resolution of hyperalgesia induced by a subsequent inflammatory stimulus. We identified that hyperalgesic priming in mice caused disturbances in mitochondrial respiration, oxidative stress, and redox balance in dorsal root ganglia (DRG) neurons. Preventing these priming-induced disturbances restored resolution of inflammatory hyperalgesia. Concurrent with these mitochondrial and metabolic changes, the expression of ATPSc-KMT, a mitochondrial methyltransferase, was increased in DRG neurons in primed mice. ATPSc-KMT overexpression in DRG neurons of naive mice induced similar mitochondrial and metabolic changes as observed after priming, leading to failure in pain resolution. Inhibition of mitochondrial respiration, knockdown of ATPSCKMT expression, or NAD+ supplementation were sufficient to restore resolution of inflammatory pain and prevent chronic pain development. Thus, inflammation-induced mitochondrial-dependent disturbances in DRG neurons promote failure in inflammatory pain resolution and drive the transition to chronic pain.
An investigation into the factors which influence attendance rates for psychology appointments in an adult intellectual disability service
Authors: Yates Luke , Brittleton Louise , Beail Nigel 
Published: August 2022

Purpose
This study aims to investigate whether factors previously shown to influence attendance rates for appointments in general practice and general mental health services also influence attendance rates in services for people with intellectual disabilities (ID).

Design/methodology/approach
Post hoc data from 452 psychology appointments, ID diagnostic and initial screening (triage) appointments were collected from the health-care files of a community adult ID psychology service. Demographic factors (age, sex) and clinical factors (waiting time, time between appointment invitation being sent and appointment being held, presence of prior telephone call or letter, type of appointment, weekday, month) were recorded along with the attendance outcome (attended/did not attend [DNA]). The impact of the COVID-19 pandemic was also explored by documenting whether the appointment predated March 2020.

Findings
No significant associations were found between any variable investigated and attendance outcome when analysing appointment data as a whole and when splitting the data between appointment type. Weekday was found to significantly be associated with attendance outcome for appointments held during COVID-19, in which more DNA appointments occurred on a Wednesday compared to the other days of the week. No other associations were found for appointments held during the COVID-19 pandemic or for appointments held prior to the COVID-19 pandemic. These results suggest that factors which influence attendance rates in general health-care settings do not necessarily generalise to ID services.

Originality/value
To the best of the authors’ knowledge, this study is the first to examine whether certain demographic and clinical factors influenced attendance rates in an adult intellectual disability service.
Exploring private university attractiveness from students’ perspective to ensure sustainable institutes: an empirical investigation from Indian perspective
Authors: Yadav Radha , Shiva Atul , Narula Sumit 
Published: August 2022

PurposeThis study aims to explore various determinants of university attractiveness and its relationship with sustainable institutes. Further, the study examines the mediating role of perceived student support and sense of belongingness on the relationship between university attractiveness and sustainable institutes.Design/methodology/approachThe data analysis was conducted with 637 responses from the students from private universities located in the northern region of India. Variance based partial least square structural equation modeling (PLS-SEM) was applied in the study to investigate the proposed conceptual model on sustainable higher institutions. Additionally, by applying PLS Predict, the predictive relevance of sustainable institutions with important and performing constructs was found out.FindingsThe results of this study indicate that university attractiveness plays a critical role in enhancing perceived student support, and it has a direct and significant impact on developing sustainable institutes. Further, students’ sense of belongingness is expressed as significant mediator between university attractiveness and sustainable institutes. The predictive relevance of the study was reported to be high. Most important indicators of university attractiveness were found to be teaching, research and publications, branding and promotion, and diversity in courses offered by the private universities.Research limitations/implicationsThe conceptual model under study can be investigated with a moderating effect of private and government universities in future. Additionally, the role of additional variables in online scenario under current pandemic situation can be assessed through the model used in this study. Future research can be done by using qualitative analysis through thematic analysis and sentiment analysis of students in higher education institutes.Originality/valueThe present study is the first to explore the mediating relationship of perceived student support and sense of belongingness with university attractiveness and sustainable institutes. The conceptual framework can prove to be important for education specialists, administrators of education institutes at university level and policymakers. The study offers effective ideas for policymakers to bring sustainability in education sector in near future especially in emerging economies and attain sustainable development goals.