bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conductas del cuidador que afectan el proceso de crianza de los niños en etapas preescolar y escolar
Authors: Jordán Granada Sharon Maidé , Pava Laguna Carolina , Mejía Valencia Tatiana 
Published: May 2022

Objetivo: Determinar las conductas del cuidador que afectan el proceso de crianza de los niños en etapas preescolar y escolar basado en la revisión bibliográfica.
Metodología: Esta revisión bibliográfica integrativa fue realizada a través de un estudio detallado, selectivo y crítico que sintetiza la información en una perspectiva unitaria y de conjunto; para mostrar resultados de investigaciones anteriores, y recoger las conclusiones de la literatura sobre las conductas del cuidador que afectan el proceso de crianza de los niños en etapas preescolar y escolar.
Resultados: Las conductas más relevantes encontradas en la literatura, que afectan el proceso de crianza de los niños son: el lenguaje inapropiado que usan los cuidadores hacia ellos, la violencia, los malos tratos, la carencia de afecto y apoyo hacia ellos. Además de estas conductas hay un factor comportamental de rol por carencia de tiempo de los padres para compartir con los hijos, esta variable de la falta de tiempo para dedicar a sus hijos, ha generado cuidadores indirectos y cambios en la conducta de los niños por mala utilización del tiempo en ellos.
Conclusiones: Esta revisión crítica de la literatura evidencio que conductas simples y cotidianas para algunas personas como el lenguaje inapropiado, la violencia, el tiempo o carencia de este, el poco afecto en el hogar afectan negativamente el proceso de crianza de los niños, y generan daños irremediables en los niños; modificando su estado de ánimo, su manera de ser, su estilo de vida, su salud y su comportamiento a largo plazo ya que serán adolescentes y adultos con dificultades sociales, e incapaces de enfrentar un mundo con adversidades diarias.
La situación de riesgo descrita en el entorno familiar de los niños desde una construcción académica de revisión de literatura, requiere una intervención oportuna desde los entes gubernamentales, sociales y jurídicos que generen estrategia pedagógica de intervención y enseñanza para los padres o cuidadores en busca de mejores conductas de crianza a la hora de educar en pro de formar niños buenos, con capacidades extraordinarias, niños sanos, niños capaces de tomar decisiones adecuadas y adultos estructurados que puedan alcanzar una calidad de vida óptima.
Responsabilidad Extracontractual del Estado por desplazamiento forzado en Colombia en el marco del conflicto armado interno
Authors: Ruiz Jaspi Diana Katherine , Trujillo Vieda Gisela 
Published: May 2022

El presente artículo de investigación expone el análisis sobre cuál ha sido el manejo jurídico frente a la responsabilidad extracontractual del Estado por desplazamiento forzado en Colombia a causa del Conflicto Armado Interno por parte de la Sección Tercera del Consejo de Estado como máximo tribunal de lo Contencioso Administrativo; igualmente, presenta la identificación de cuáles son los regímenes de responsabilidad adoptados y los títulos jurídicos de imputación, además de establecer cuáles fueron los daños materiales e inmateriales reconocidos y el medio de control utilizado en las demandas. Metodológicamente, se desarrolló un análisis de tipo dogmático jurídico con enfoque cualitativo y analítico. Entre las conclusiones, se identifica que el Estado como garante de la seguridad en Colombia incurre en una falla en el servicio cuando se presentan eventos de desplazamiento; igualmente, se plantea que, a pesar de que ha existido una desprotección por parte del Estado hacia a las víctimas del Conflicto Armado Interno, es necesario realizar un análisis que permita identificar esas falencias a fin de aunar esfuerzos para evitar que dichas situaciones se sigan presentando.
El deber de la Justicia Transicional: como principio y no como norma de regla
Authors: Lasso López Raúl Arturo 
Published: May 2022

El presente artículo retoma los conceptos de “principios y normas” definidos por Uprimny (2014) y colaboradores en su documento Justicia para la paz; Crímenes atroces, derecho a la Justicia y paz negociada, y se adicionan los conceptos “sobre principios y reglas” de Atienza y Ruiz (1991), para entregar una aproximación conceptual que superpone el concepto del deber de la justicia transicional como un “principio” y que antecede al concepto de “norma reglada”; se concentra la atención en el caso Colombiano como escenario en el que está en juego abordar el tema del conflicto armado como la necesidad de paz, verdad y reparación para posteriormente avanzar en concomitancia con el deber normativo del Estado de investigar, juzgar y sancionar. Es precisamente en este aspecto que se asegura que los avances para obtener una Paz estable y duradera como se promueve con las negociaciones actuales, parten del entendimiento de que la tesis sustentada en el presente artículo adquiere magnitud cuando se intenta soslayar y menospreciar el concepto del principio, antepuesto al de norma de regla.
The MiR-101/EZH2 negative feedback signaling drives oxygen–glucose deprivation/reperfusion-induced injury by activating the MAPK14 signaling pathway in SH-SY5Y cells
Authors: Gu Hao , Chen Qing , Li Jian 
Published: May 2022

MiR-101 has been reported to be involved in neuroinflammation, neuronal injury and neurotoxicity. However, the specific role and mechanism of miR-101 in ischemia/reperfusion (I/R)-induced neuronal injury remain largely unknown. Our study found that after oxygen–glucose deprivation/reperfusion (OGD/R) exposure, the level of miR-101 in SH-SY5Y cells was significantly decreased, which was accompanied by a decrease in cell viability, and an increase in LDH release and apoptosis. MiR-101 overexpression (miR-101 mimics) significantly promoted viability and inhibited LDH release and apoptosis in OGD/R-exposed SH-SY5Y cells. Luciferase reporter assay indicated that enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) was a direct target of miR-101, and EZH2 siRNA obviously increased the viability, inhibited LDH release and apoptosis in OGD/R-exposed SH-SY5Y cells. Besides, EZH2 siRNA could inhibit the activation of mitogen-activated protein kinase (MAPK14) signaling pathway and the MAPK14 agonist (anisomycin) could reverse EZH2 siRNA-induced increase in cell viability, and decreases in LDH release and apoptosis. Furthermore, when the methyltransferase activity of EZH2 was inhibited by its specific inhibitor GSK126, the level of miR-101 was increased in OGD/R-exposed SH-SY5Y cells. Additionally, EZH2 siRNA upregulated miR-101 expression in OGD/R-exposed SH-SY5Y cells. Taken together, our findings reveal that miR-101/EZH2 negative feedback signaling drives OGD/R-induced injury by activating the MAPK14 signaling pathway in SH-SY5Y cells.
Electronic Angular Tunneling Effect
Authors: Sales Jorge Henrique de Oliveira , Lima Cássio Almeida , Santos Gislan Silveira , Suzuki Alfredo Takashi 
Published: May 2022

In this article we show that the probability for an electron tunneling a rectangular potential barrier depends on its angle of incidence measured with respect to the normal line. The majority of the studies in the field consider a one-dimensional tunneling of an electron of mass in a potential barrier along the -axis. Using a two-dimensional approach, we observed that the angle of incidence of the electron influences the probability of tunneling.
Career Development among Undergraduate Students of Madda Walabu University, South East Ethiopia
Authors: Getachew Abera , Daniel Gobena 
Published: May 2022

Career guidance and counselling is a vaguely implemented concept in most educational institutions, governmental and non-governmental organisations. The severity of the problem and scarcity of relevant information among university students have prompted the undertaking of this study the aim of whichwas to assess career development among undergraduate students of Madda Walabu University. Crosssectional study design was employed to gather quantitative data through self-administered structured questionnaires. The participants in the study were 605 undergraduate students of Madda WalabuUniversity who were recruited through multi-stage sampling. The analysis employed SPSS-20.0 to calculate t-test and ANOVA. The findings suggested that socio-demographic variables were important in determining the factors, levels and variances in career development. The participants’ perceived benefitof career development has shown that there is a statistically significant difference between the expected mean and the observed mean, t(604) =29.11, p<.01. However, they had only some unsatisfactory information on career development and most of them (47.4%) did not have a bright future. The resultof this study showed that career development is important in understanding students’ personal values, clarifying their goals, career choice directions and job-searching skills. Because the respondents’ reported information on career development is so poor, lack of future direction and decreased performance areinevitable. It is suggested that career counselling services are seen to be highly recommendable in advancing students’ career development in many aspects.
Color application in vernacular architecture in Southern India: An Intangible cultural phenomenon?
Authors: Schellini Marcelo , Rahimi Ali 
Published: May 2022

The study of color aesthetics should always consider color interactions. This study aimed to understand the color application in southern India by identifying it in the cityscapes and analyzing its characteristics. Field observations, a survey, and interviews were undertaken. An online questionnaire was administered to 39 undergraduate and master’s degree students in Industrial Design courses at VIT University Vellore. The article discusses the appropriate methodology for color criticism research and its multidisciplinary field. The study concludes that color in Southern India has a complex and elaborated application. Color contrast and saturation can be used not merely to enhance and distinguish shapes and forms creating the visual effect of detachment between its elements but as a paradoxical economic status indicator.

Keywords: Architecture; Color; Criticism; Design; India; Visual Culture.
ANALYSIS OF THE IMPACT OF ATTRACTION AND GENERATION ON THE PERFORMANCE OF JALANKAPTEN A. BAKARUDIN, JAMBI CITY
Authors: Nurdin Ade , Fitri Yanuar , Nuklirullah Nuklirullah 
Published: May 2022

One of the supports for the economy in Jambi province is the Shopping Center Development of shopping centers. Jambi Town Square Mall is one of the shopping centers in the City of Jambid with the Jambi Town Square Mall resulting in an additional volume of traffic on Jalan Kapten A. Bakarrudin No 88 Sipin Jambi City which causes a decrease in the performance of Jalan Kapten A. Bakarrudin No 88 Sipin.
From the results of a field survey carried out for four days, the peak of the vehicle attraction at Jambi Town Square Mall on Monday 12 August 2020 at 19.00 WIB - 20.00 WIB was 415 vehicles / hour, Saturday 15 August 2020 at 19.00 WIB - 20.00 WIB as many as 421 vehicles / hour, Sunday, August 16 2020 at 19.00 WIB - 20.00 WIB, 596 vehicles / hour, Tuesday 375 vehicles / hour. The peak of the Jambi Town Square Mall Vehicle awakening is on Wednesday 12 August 2020 at 20.00 WIB - 21.00 WIB with a total of 411 vehicles / hour. Saturday 15 August 2020 at 20.00 WIB - 21.00 WIB with a total of 475 vehicles / hour, Sunday 16 August 2020 at 17.00 WIB - 18.00 WIB with a total of 521 vehicles / hour, Tuesday, August 18 2020 at 20.00 WIB - 21.00 WIB with a total of 469 vehicles / hour, the highest DS value is 1.028 at 17.00 WIB - 18.00 WIB
Prevalence of Psychological Distress Among Working-Age Adults in the United States, 1999–2018
Authors: Daly Michael 
Published: May 2022

Objectives. To test whether the prevalence of reported psychological distress increased among working-age adults in the United States between 1999 and 2018. Methods. I examined psychological distress in the past 30 days using the Kessler-6 Distress Scale, completed by 403 223 participants aged 25 to 64 years across 20 annual waves of the National Health Interview Study conducted from 1999 to 2018. I examined overall and demographic-specific trends. Results. The prevalence of psychological distress in the past 30 days increased from 16.1% in 1999–2000 to 22.6% in 2017–2018, an increase of 6.5 percentage points (95% confidence interval [CI] = 5.6, 7.3) or 40% from 1999–2000 levels. Statistically significant increases in the prevalence of distress were observed across all age, gender, race/ethnicity, and educational attainment subgroups examined. Rates of serious psychological distress increased from 2.7% in 1999–2000 to 4% in 2017–2018, an increase of 1.3 percentage points (95% CI = 0.9, 1.6). Conclusions. Since 1999, there has been an upward trend in reported psychological distress among working-aged adults in the United States. (Am J Public Health. 2022;112(7):1045–1049. https://doi.org/10.2105/AJPH.2022.306828 )
The Impact of the Development of 5g Technologies on the Ideological and Political Education of College Students
Authors: Qiang Lixian 
Published: May 2022

Abstract
Poor teaching effectiveness is currently a major concern at China's colleges and universities. The 5G Internet age has delivered massive advancements to lifestyle, culture, and work, and its convenience and efficacy have aided civilization's express advancement. It has brought with it a host of difficulties, as well as new changes and benefits for university students' ideological and political education (IPE). However, the Internet's openness and dispersion have certain negative repercussions, especially in terms of IPE in institutions, where the consequences are significant. In this paper, we have proposed a 5G-based IPE. In the opening, we collect the dataset to initialize the proposed flow. The collected dataset can be pre-processed using normalization. After the input education details have been preprocessed, the education detail is grouped by utilizing the Hierarchical K-means technique. The aspects can then be extracted using the variational autoencoder (VAE). After it has been reviewed for viability, the data can be stored in a database for future research. Then, using the Boosted TCP protocol (BTCP), the workable data can be sent to the identity of the student, and also the BTCP used to convert data effectively. The presentation of this protocol improved using Enhanced fruit fly optimization (EFFO). Performances such as throughput, good-put, transmission rate, and execution time are examined, and the results are compared to those of other studies.
Proteogenomic Landscape and Clinical Characterization of GH-Producing Pituitary Adenoma
Authors: Tanaka Tomoaki , Yamato Azusa , Nagano Hidekazu , Gao Yue , Matsuda Tatsuya , Hashimoto Naoko , Nakayama Akitoshi , Yamagata Kazuyuki , Yokoyama Masataka , Gong Yingbo , Shi Xiaoyan , Horiguchi Kentaro , Iwadate Yasuo , Fukuyo Masaki , Rahmutulla Bahityar , Kaneda Atsushi , Hasegawa Yoshinori , Kawashima Yusuke , Ohara Osamu , Ishikawa Tetsuo , Kawakami Eiryo , Nakamura Yasuhiro , Inoshita Naoko , Fukuhara Noriaki , Nishioka Hiroshi , Yamada Shozo 
Published: May 2022

Abstract
The clinical characteristics of growth hormone (GH)-producing pituitary adenomas vary across patients. In this study, we aimed to integrate the genetic alterations, protein expression profiles, transcriptomes, and clinical characteristics of GH-producing pituitary adenomas to detect molecules associated with acromegaly characteristics. Targeted capture sequencing and copy number analysis of 36 genes and non-targeted proteomics analysis were performed on fresh-frozen samples from 121 sporadic GH-producing pituitary adenomas. Targeted capture sequencing revealed GNAS as the only driver gene, as previously reported. Classification by consensus clustering using both RNA sequencing and proteomics revealed many similarities between the proteome and the transcriptome. Gene ontology analysis was performed for differentially expressed proteins between wild-type and mutant GNAS samples identified by non-targeted proteomics analysis and involved in G protein–coupled receptor (GPCR) pathways. The results suggested that GNAS mutations impact endocrinological features in acromegaly through GPCR pathway induction. ATP2A2 and ARID5B correlated with the GH change rate in the octreotide loading test, and WWC3, SERINC1, and ZFAND3 correlated with the tumor volume change rate after somatostatin analog treatment. These results identified a biological connection between GNAS mutations and the clinical and biochemical characteristics of acromegaly, revealing novel molecules associated with acromegaly that may affect medical treatment efficacy.
Wiltse TTIF approach for the treatment of single-segment thoracic spinal tuberculosis in the elderly with osteoporosis: a retrospective study of 20 cases
Authors: Zeng Hao , Yang Jinsong , Liao Simi , Liang Yingfang , Moro Abu , Ou Yufu , Su Haixia , Li Gui , Wang Dongling , Chen Guanghui , Qin Hongyu 
Published: May 2022

Abstract
BackgroundThis study aims to explore the clinical efficacy of Wiltse approach transforaminal thoracic interbody fusion (TTIF) for the treatment of single-segment thoracic spinal tuberculosis in elderly patients with and osteoporosis and neurological deficits.MethodsThis is a retrospective analysis of 20 elderly patients who underwent Wiltse approach TTIF in our hospital from January 2017 to January 2019. The follow-up time was 37.15±7.37 months (range 24-48 months); and the preoperative kyphotic angle was 35.41±6.71°. The Frankel spinal cord injury classification was used to assess the degree of neurological deficit. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are used to track the activity of tuberculosis (TB). While femoral neck bone mineral density measurement T value (BMD T) was used to assess the degree of osteoporosis.ResultThe 20 elderly patients with spinal tuberculosis (STB) were completely cured without recurrence. The postoperative kyphotic angle was 8.80±0.79°, without significant loss of correction at the last follow-up. Bone graft fusion was observed within 6-9 months with all patients reporting that their back pains were relieved. The neurological condition of all patients improved after the operation.ConclusionsWiltse TTIF treatment combined with anti-tuberculosis chemotherapy is adequate for obtaining satisfactory healing of single-segment thoracic tuberculosis in elderly patients with osteoporosis.
MISPR: An automated infrastructure for high-throughput DFT and MD simulations
Authors: Atwi Rasha , Bliss Matthew , Makeev Maxim , Rajput Nav Nidhi 
Published: May 2022

Abstract
Computational tools provide a unique opportunity to study and design optimal materials by enhancing our ability to comprehend the connections between their atomistic structure and functional properties. However, designing materials with tailored functionalities is complicated due to the necessity to integrate various computational-chemistry software (not necessarily compatible with one another), the heterogeneous nature of the generated data, and the need to explore vast chemical and parameter spaces. The latter is especially important to avoid bias in scattered data points-based models and derive statistical trends only accessible by systematic datasets. Here, we introduce a robust high-throughput multi-scale computational infrastructure coined MISPR (Materials Informatics for Structure-Property Relationships) that seamlessly integrates classical molecular dynamics (MD) simulations with density functional theory (DFT). By enabling high-performance data analytics and coupling between different methods and scales, MISPR addresses critical challenges arising from the needs of automated workflow management and data provenance recording. The major features of MISPR include automated DFT and MD simulations, error handling, derivation of molecular and ensemble properties, and creation of output databases that organize results from individual calculations to enable reproducibility and transparency. In this work, we describe fully automated DFT workflows implemented in MISPR to compute various properties such as nuclear magnetic resonance chemical shift, binding energy, bond dissociation energy, and redox potential with support for multiple methods such as electron transfer and proton-coupled electron transfer reactions. The infrastructure also enables the characterization of large-scale ensemble properties by providing MD workflows that calculate a wide range of structural and dynamical properties in liquid solutions. MISPR employs the methodologies of materials informatics to facilitate understanding and prediction of phenomenological structure-property relationships, which are crucial to designing novel optimal materials for numerous scientific applications and engineering technologies.
Microbial Oil Production from Waste Rose Pulp by Newly Isolated Wickerhamomyces subpelliculosus 6
Authors: KIVANC Merih , Otuzbiroglu Ayşe 
Published: May 2022

Abstract
Objective
The pulp, remaining after the rose oil and rose water are extracted from the rose, are left around and cannot be utilized economically. It was aimed in this study to produce microbial oil for the first time by means of W. subpeliculosa in medium containing waste rose pulp as a carbon source. The aim of ceasing the high amount of rose pulp to be a pollutant and also making contribution to the biodiesel production, which is a cheap and environmentally-friendly fuel for the national economy.
Methods
Two applications were made on the waste rose pulp. One of them is that the waste rose pulp has been treated with water. In the second application, it was pretreated with 1% H2SO4. “Box Behnken Experimental Design Method”, having 3 variables with 2 replicates from 15 experimental points, was used in the optimization experiments with the response surface method of the lipid production parameters, containing temperature, and inoculum age and inoculum volume.
Results
45% oil yield was obtained from W. subpelliculosus with the waste rose pulp treated with acid and the microbial lipid was produced for the first time in this study. The profile of fatty acid produced consists of 45% palmitic acid, 42,62% stearic acid and 7,38% oleic acid and its fatty acid composition is highly similar to the vegetable oil acids.
Conclusion
It is considered to be a suitable material for biodiesel production.