bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protocol for the ORION trial (RadiO fRequency ablatION for haemorrhoids): a randomised controlled trial
Authors: Girling C. , Lee M. J. , Vimalchandran D. , Jayne D. J. , Stancliffe S. , Wailoo A. , Bradburn M. , Hind D. , Bursnall M. , Robinson L. K. , Brown S. R. 
Published: November 2022

Abstract
Background
Haemorrhoids are common and can significantly impact the personal and working lives of individuals. Those with more severe symptoms and those not responding to conservative management may require surgery. Current surgical techniques are associated with a degree of postoperative discomfort which may delay return to normal activity. Recurrence is lower in more radical procedures but resulting pain is higher. Radiofrequency ablation (RFA) is a new technique that is gaining popularity and has several hypothesised benefits, including reduced pain and recurrence. However, available evidence is limited. A recent overview from the National Institute for Health and Clinical Excellence recommended more research, in the form of randomised controlled trials, be carried out before further investment is made by national health services. Our aim is to assess whether RFA is at least as good in terms of recurrence as existing surgical interventions, but superior in terms of pain, for patients with symptomatic grade II and III haemorrhoids.

Methods
The RadiO fRequency ablatION for haemorrhoids (ORION) trial will be a pragmatic multicentre patient/assessor-blind parallel group-controlled trial with economic evaluation. The target sample size is 376 participants (188 per arm) and is based on two co-primary endpoints: (i) a non-inferiority design for recurrence and (ii) superiority design for pain at seven days. Participants with grade II or III haemorrhoids will be recruited in 16 National Health Service hospitals and randomised (1:1) to either RFA or surgeon’s choice of surgery.

Conclusions
Results will inform future practice for the treatment of grade II–III haemorrhoids and provide evidence for national health services on future investments in RFA.

Trial registration
ISRCTN14474552.
Statistical evidence and the criminal verdict asymmetry
Authors: Fried Avital 
Published: November 2022

AbstractEpistemologists have posed the following puzzle, known as the proof paradox: Why is it intuitively problematic for juries to convict on the basis of statistical evidence and yet intuitively unproblematic for juries to convict on the basis of far less reliable, non-statistical evidence? To answer this question, theorists have explained the exclusion of statistical evidence by arguing that legal proof requires certain epistemic features. In this paper, I make two contributions to the debate. First, I establish the Criminal Verdict Asymmetry, a previously-unarticulated asymmetry between the epistemic norms of guilty and not guilty verdicts. I argue that the prosecution and defense’s different epistemic burdens influence whether statistical evidence can generate the type of verdict each side pursues. Second, I point out a mistake in how theorists have understood the role of statistical evidence in criminal trials. Though epistemologists have primarily focused on whether statistical evidence can generate specific epistemic features required for convictions, I consider whether statistical evidence can demonstrate a lack of such features. I find that there are epistemic advantages to allowing the defense to introduce statistical evidence which can reveal the prosecution’s failure to prove the defendant’s guilt.
Non-destructive Evaluation of Workpiece Properties along the Hybrid Bearing Bushing Process Chain
Authors: Fricke Lara Vivian , Thürer Susanne Elisabeth , Kahra Christoph , Bährisch Susanne , Herbst Sebastian , Nürnberger Florian , Behrens Bernd-Arno , Maier Hans Jürgen , Klose Christian , Barton Sebastian 
Published: November 2022

AbstractTo combine the advantages of two materials, hybrid bulk metal workpieces are attractive for subsequent processes such as metal forming. However, hybrid materials rely on the initial bond strength for the effective transfer of applied loads. Thus, a non-destructive evaluation of the bonding along the production process chain is of high interest. To evaluate to what extent non-destructive testing can be employed to monitor the bonding quality between the joining partners steel and aluminum and to characterize the age hardening condition of the aluminum component, ultrasonic testing and electrical conductivity measurements were applied. It was found that a lateral angular co-extrusion process can create homogeneous bonding although the electrical conductivity of the aluminum is altered during processing. A previous bonding before the subsequent die forging process leads to a sufficient bonding in areas with little deformation and is therefore, advantageous compared to unjoined semi-finished products, which do not form a bonding if the deformation ratio is too small. An influence of the subsequent heat treatment on the bonding is not visible in the ultrasonic testing signals though a homogenized electrical conductivity can be detected, which indicates uniform artificial aging conditions of the aluminum alloy
Energy Flux Characterisation of Atmospheric Pressure Plasma Spray Torches with Passive Thermal Probes
Authors: Reck Kristian A. , Hansen Luka , Stummer Maximilian , Kewitz Thorben , Testrich Holger , Hinterer Andreas , Foest Rüdiger , Kersten Holger 
Published: November 2022

AbstractPassive thermal probes were applied on two different plasma spraying devices to gain a detailed understanding of the energy flux towards the substrate under atmospheric pressure. The challenge of very high thermal load was solved by using an advanced time-resolved measuring and evaluation technique. The combination with a controlled movement of the jets allowed to obtain insightful radial profiles. The energy flux to the substrate changes linearly to the electrical input power. When adding diatomic gases (H2/N2) to the gas mixture the energy flux increases significantly, suggesting a more efficient energy transport. For increasing the axial distance, the energy flux shows a quadratic reduction. The obtained radial profiles are exemplarily utilized to show the inhomogeneous effect of powder injection on the energy flux distribution.
Inhibition of BRD4 enhanced the tumor suppression effect of dasatinib in gastric cancer
Authors: Shen Hao , Hu Xuefei , Yang Xinrui , Chen Jiahui , Fu Yating , He Hongwei , Shi Yongkang , Zeng Rong , Chang Wenjun , Zheng Shangyong 
Published: November 2022

AbstractBRD4, a member of the bromodomain and extraterminal (BET) family, is elevated in multiple cancer tissues, including gastric cancer (GC). Targeted therapy with BRD4 may help improve the overall survival of patients with GC. Meanwhile, the approved multi-target kinase inhibitor, dasatinib, was recently reported to show varied tumor-suppressive effects in GC cells. This study investigated BRD4 expression in vivo and in vitro using immunohistochemistry and western blotting, respectively. We discussed the relationship between BRD4 expression and patient prognosis. Next, the antitumor efficacy of dasatinib was measured in BRD4-knockdown GC cells to determine the role of BRD4 blockage in dasatinib treatment. Finally, molibresib, a BET inhibitor, was used to measure the cooperative function of BRD4 inhibition and dasatinib treatment in three GC cell lines. Epithelial BRD4 expression was higher in tumoral and metastatic tissues and was strongly associated with unfavorable tumor, node, and metastasis stages and survival. BRD4 expression was heterogeneous in the three GC cell lines tested in vitro. In SGC7901, a BRD4-high GC cell line, knockdown of BRD4 using specific siRNAs suppressed cell growth individually and cooperatively with dasatinib. Moreover, molibresib and dasatinib showed a cooperative effect in suppressing the proliferation of BRD4-high GC cells. In conclusion, we confirmed that increased epithelial BRD4 expression is associated with poor disease stage and prognosis in GC and BRD4 blockage might be a valuable strategy to improve the sensitivity of dasatinib and other drugs in the chemotherapy of advanced GC.
Zeitenwende im arktisch-nordatlantischen Raum. Außen- und sicherheitspolitische Folgen des NATO-Beitritts von Finnland und Schweden
Authors: Ålander Minna , Paul Michael , Swistek Göran 
Published: November 2022

ZusammenfassungDie Zeitenwende ist kein auf Deutschland beschränktes Phänomen. Mit dem Angriffskrieg gegen die Ukraine hat Russland nachhaltige Änderungen in der Außen- und Sicherheitspolitik nordischer Staaten bewirkt. Es ist eine vom russischen Präsidenten provozierte Ironie der Geschichte, dass er in Finnland und Schweden den Beitritt zur NATO bewirkt hat. Der Beitritt ist ein zweischneidiges Schwert: Die beiden Länder tragen zu einer qualitativen Verbesserung der Fähigkeiten zur kollektiven Verteidigung bei, gleichzeitig erweitert sich mit dem Beitritt das Verantwortungsgebiet der NATO deutlich.
Artificial intelligence and machine learning
Authors: Kühl Niklas , Schemmer Max , Goutier Marc , Satzger Gerhard 
Published: November 2022

AbstractWithin the last decade, the application of “artificial intelligence” and “machine learning” has become popular across multiple disciplines, especially in information systems. The two terms are still used inconsistently in academia and industry—sometimes as synonyms, sometimes with different meanings. With this work, we try to clarify the relationship between these concepts. We review the relevant literature and develop a conceptual framework to specify the role of machine learning in building (artificial) intelligent agents. Additionally, we propose a consistent typology for AI-based information systems. We contribute to a deeper understanding of the nature of both concepts and to more terminological clarity and guidance—as a starting point for interdisciplinary discussions and future research.
Branching Brownian motion in a periodic environment and uniqueness of pulsating traveling waves
Authors: Ren Yan-Xia , Song Renming , Yang Fan 
Published: November 2022

AbstractUsing one-dimensional branching Brownian motion in a periodic environment, we give probabilistic proofs of the asymptotics and uniqueness of pulsating traveling waves of the Fisher–Kolmogorov–Petrovskii–Piskounov (F-KPP) equation in a periodic environment. This paper is a sequel to ‘Branching Brownian motion in a periodic environment and existence of pulsating travelling waves’ (Ren et al., 2022), in which we proved the existence of the pulsating traveling waves in the supercritical and critical cases, using the limits of the additive and derivative martingales of branching Brownian motion in a periodic environment.
The European Court of Justice's Transformation of its Approach towards Preliminary References from Member State Administrative Bodies
Authors: BROBERG Morten , FENGER Niels 
Published: November 2022

AbstractAccording to Article 267 TFEU, a ‘court or tribunal of a Member State’ can make a preliminary reference to the Court of Justice. The Court applies a single, homogeneous definition of a ‘court or tribunal’. This has allowed it to admit references from those specialised, independent, administrative bodies that in several Member States have been established instead of administrative courts to decide claims under public law, including EU law. Whether such a ‘dispute settling’ body is entitled to submit a preliminary reference normally depends upon whether it commands sufficient ‘independence’ vis-à-vis both the parties to the dispute and the public administration as such. The Court has tightened these requirements appreciably in connection with the threats against the independence of the judiciary in some Member States, and the consequent more prominent roles that Articles 19 TEU and 47 of the Charter have come to play. Whereas safeguarding the rule of law is of utmost importance, these provisions pursue objectives within the Union's legal order which are materially different from those pursued by Article 267. In this article, it is therefore argued that the Court should apply different constructions of the independence criterion with respect to these provisions.
Demographic composition of National Institutes of Health Clinical and Translational Science Awards (CTSA) Program principal investigators, scholars, and trainees
Authors: Rubio Mercedes , Baker Heather L. , Doyle Jamie Mihoko 
Published: November 2022

Abstract
Little has been published on the demographic composition of the clinical and translational science research workforce within the Clinical and Translational Science Awards (CTSA) Program despite the well-documented need for greater diversity in the biomedical research workforce. Analyses of workforce demographic reveal that women and members of underrepresented groups remain persistently underrepresented in the CTSA hub and training components principal investigators. In contrast, in the CTSA Program career development and training programs, females have greater representation as participants, and non-Whites were better represented in training programs.
Paul the Middle Platonist? Exegetical Traditions on Timaeus 28c and the Characterization of Paul in Acts 17:16–31
Authors: Hubbard Jeffrey M. 
Published: November 2022

AbstractPaul’s speech to the Areopagus in Acts 17 places the apostle in philosophical dialogue with Stoics and Epicureans. This article identifies important points of contact between Paul’s speech and Middle Platonic exegesis of a famous Platonic phrase from Timaeus 28c. There, the philosopher declares that the maker and father of the world is hard to find, and even more difficult to talk about. Many later interpreters of Plato commented on the dictum. Middle Platonists such as Plutarch mused about the theological implications of naming god both “maker” and “father.” Jewish and Christian interpreters like Philo and Justin employed Plato’s phrase to describe their access to divine revelation. The first portion of this article argues that the Areopagus speech contains evidence of similar exegesis, both in its references to god’s roles as maker and father and in Paul’s claim to declare the unknown god. These resonances do more than clarify the author’s philosophical background; they also have previously unexplored implications for our understanding of Paul’s characterization in Acts 17. The second half of the article argues that in aligning Paul with the Platonic tradition, the author participates in an established Greco-Roman practice of depicting the Platonists, Stoics, and Epicureans in theological dialogue.
Beyond the Underdog Mentality: Philo-Semitism amongst Protestant Rescuers in Wartime Ukraine
Authors: Ostapenko Raisa 
Published: November 2022

AbstractIn Ukraine, as was the case across occupied Europe, while most residents of any given locality divided into bystanders, collaborators, and accomplices during the Holocaust, a minority turned to rescue work. Faith-motivated rescue work by large institutions or individuals representing prominent branches of Christianity is well documented; its prevalence exemplifies the critical role that the altruism of individual members of the clergy, laity, and religious orders played in the survival of many Jews. However, rescuers from less prominent denominations of Christianity, amongst them Baptists, Evangelicals, Seventh-day Adventists, and Sabbatarians, are less spoken about, although these rescuers were often equally as motivated to rescue and more poorly resourced to do so due to disadvantageous political circumstances. Some scholars suggest that it was their “underdog” identity that made such groups empathize with persecuted Jews, but primary testimony offers an even more intriguing perspective: it was the philo-Semitic underpinnings of some members of the minority Protestant denominations in question that provided a broad theological basis for rescuing Jews, transcending the sociopolitical phenomenon of the common underdog mentality and even more widespread ecumenical obligations for being a good Christian.
Effect of free-ranging cattle on mammalian diversity: an Austral Yungas case study
Authors: Cuyckens Griet An Erica , Gonzalez Baffa Trasci Noelia Viviana , Perovic Pablo Gastón , Malizia Lucio Ricardo 
Published: November 2022

AbstractExtensive cattle ranging is an important economic activity in mountains, with diverse effects on native mammal communities. The effects of cattle Bos taurus can be negative, positive or neutral, mostly depending on the stocking rate. We examined the effect of cattle on the diversity and abundance of native mammalian species in the Austral Yungas region of Argentina, considering environmental variables, land protection status, and human influence. Using 12,512 trap-nights from 167 camera-trap stations over 11 years (2009–2019), we calculated a relative abundance index using camera events and used generalized linear models to estimate the effect of cattle on small mammals, large herbivores, species of conservation concern and felids. Cattle had different effects on each group of native mammals. We observed a lower abundance of large native herbivores and the absence of small mammals in areas with high cattle abundance. The tapir Tapirus terrestris, jaguar Panthera onca and white-lipped peccary Tayassu pecari are rare in the Yungas and therefore potentially vulnerable to extinction there. Conservation of small felids and low cattle abundance could be compatible, but felids are threatened by other anthropogenic influences. Native mammalian diversity and richness were related to land protection status. The entire ecoregion is potentially suitable for cattle, suggesting the potential for further threats, and that cattle should be excluded from strictly protected areas. To ensure extensive cattle ranging is compatible with wildlife conservation in areas where exclusion is not possible, we recommend improved management of cattle and moderate stocking rates.
The associations between depressive symptoms, functional impairment, and quality of life, in patients with major depression: undirected and Bayesian network analyses
Authors: Zhou Jia , Zhou Jingjing , Feng Lei , Feng Yuan , Xiao Le , Chen Xu , Yang Jian , Wang Gang 
Published: November 2022

AbstractBackgroundDepressive symptoms, functional impairment, and decreased quality of life (QOL) are three important domains of major depressive disorder (MDD). However, the possible causal relationship between these factors has yet to be elucidated. Moreover, it is not known whether certain symptoms of MDD are more impairing than others. The network approach is a promising solution to these shortfalls.MethodsThe baseline data of a multicenter prospective project conducted in 11 governances of China were analyzed. In total, 1385 patients with MDD were included. Depressive symptoms, functioning disability, and QOL were evaluated by the 17-item Hamilton Depression Rating Scale (HAMD-17), the Sheehan Disability Scale (SDS), and the Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form (Q-LES-Q-SF). The network was estimated through the graphical Least Absolute Shrinkage and Selection Operator (LASSO) technique in combination with the directed acyclic graph.ResultsThree centrality metrics of the graphical LASSO showed that social life dysfunction, QOL, and late insomnia exhibited the highest strength centrality. The network accuracy and stability were estimated to be robust and stable. The Bayesian network indicated that some depressive symptoms were directly associated with QOL, while other depressive symptoms showed an indirect association with QOL mediated by impaired function. Depressed mood was positioned at the highest level in the model and predicted the activation of functional impairment and anxiety.ConclusionsFunctional disability mediated the relationship between depressive symptoms and QOL. Family functionality and suicidal symptoms were directly related to QOL. Depressed mood played the predominant role in activating both anxiety symptom and functional impairment.
Culture Change in Long-Term Care-Post COVID-19: Adapting to a New Reality Using Established Ideas and Systems
Authors: Iyamu Ihoghosa , Plottel Louis , Snow M. Elizabeth , Zhang Wei , Havaei Farinaz , Puyat Joseph , Sawatzky Richard , Salmon Amy 
Published: November 2022

AbstractThe response to the COVID-19 pandemic in long-term care (LTC) has threatened to undo efforts to transform the culture of care from institutionalized to de-institutionalized models characterized by an orientation towards person- and relationship-centred care. Given the pandemic’s persistence, the sustainability of culture-change efforts has come under scrutiny. Drawing on seven culture-change models implemented in Canada, we identify organizational prerequisites, facilitatory mechanisms, and frontline changes relevant to culture change that can strengthen the COVID-19 pandemic response in LTC homes. We contend that a reversal to institutionalized care models to achieve public health goals of limiting COVID-19 and other infectious disease outbreaks is detrimental to LTC residents, their families, and staff. Culture change and infection control need not be antithetical. Both strategies share common goals and approaches that can be integrated as LTC practitioners consider ongoing interventions to improve residents’ quality of life, while ensuring the well-being of staff and residents’ families.
A deterministic gradient-based approach to avoid saddle points
Authors: Kreusser L. M. , Osher S. J. , Wang B. 
Published: November 2022

AbstractLoss functions with a large number of saddle points are one of the major obstacles for training modern machine learning (ML) models efficiently. First-order methods such as gradient descent (GD) are usually the methods of choice for training ML models. However, these methods converge to saddle points for certain choices of initial guesses. In this paper, we propose a modification of the recently proposed Laplacian smoothing gradient descent (LSGD) [Osher et al., arXiv:1806.06317], called modified LSGD (mLSGD), and demonstrate its potential to avoid saddle points without sacrificing the convergence rate. Our analysis is based on the attraction region, formed by all starting points for which the considered numerical scheme converges to a saddle point. We investigate the attraction region’s dimension both analytically and numerically. For a canonical class of quadratic functions, we show that the dimension of the attraction region for mLSGD is
$\lfloor (n-1)/2\rfloor$
, and hence it is significantly smaller than that of GD whose dimension is
$n-1$
.
Severe headache in a middle-aged woman after device closure of a ventricular septal defect
Authors: Lee Jungbin , Song Jinyoung 
Published: November 2022

AbstractReversible cerebral vasoconstriction syndrome presents with thunderclap headache and represents a group of conditions that show reversible multifocal narrowing of cerebral arteries. Some patients who undergo device closure of an atrial septal defect complain of headache, which are posited as a migraine. Here we report a case of severe headache due not to migraine but reversible cerebral vasoconstriction syndrome after device closure of a ventricular septal defect.
Humanness as performance
Authors: Barrett John C. 
Published: November 2022

AbstractIf archaeology is the examination of historical conditions with reference to a surviving material residue, then one way in which these conditions might be characterized is as the different ways they had enabled the development of different forms of humanness. The historical construction of this diversity is discussed here as the ways that the relationships between humans and things had been performed. This means that the practice of archaeology must question the recent desire to adopt a flat ontology that defines archaeology as the ‘discipline of things’. It is argued that it was by means of the performances established between humans and their various objects of concern that different forms of human life were able to define themselves. The implications of this argument for the practice of archaeology are explored.