bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toxoplasma gondii and Rickettsia spp. in ticks collected from migratory birds in the Republic of Korea
Authors: Truong A.-Tai , Yoo Mi-Sun , Min Subin , Lim Ji-Yeon , Seo Hyun-Ji , Kim Heung-Chul , Chong Sung-Tae , Klein Terry A. , Park Chang-uk , Cho Sook-Young , Choi Chang-Yong , Kwon Young-Soo , Kim Miran , Yoon Soon-Seek , Cho Yun Sang 
Published: July 2022

AbstractMigratory birds disperse ticks and associated tick-borne pathogens along their migratory routes. Four selected pathogens of medical importance (Coxiella burnetii, Rickettsia spp., Francisella tularensis, and Toxoplasma gondii) were targeted for detection in 804 ticks (365 pools) collected from migratory birds at Hong and Heuksan Islands in the Republic of Korea (ROK) from 2010 to 2011 and 2016. Toxoplasma gondii and Rickettsia spp., were detected in 1/365 (0.27%) and 34/365 (9.32%) pools of ticks, respectively. T. gondii and five rickettsial species were recorded in ticks collected from migratory birds for the first time in ROK. The five rickettsial species (R. monacensis, Candidatus Rickettsia longicornii, R. japonica, R. raoultii, and R. tamurae) were identified using sequence and phylogenetic analysis using ompA and gltA gene fragments. Rickettsia spp. are important pathogens that cause rickettsiosis in humans, with cases recorded in the ROK. These results provide important evidence for the potential role of migratory birds in the introduction and dispersal of T. gondii and Rickettsia spp. along their migratory routes and raise awareness of potential transmission of zoonotic tick-borne pathogens associated with migratory birds in the ROK.
Association between acetabular dysplasia and sagittal spino-pelvic alignment in a population-based cohort in Japan
Authors: Harada Teiji , Hashizume Hiroshi , Taniguchi Takaya , Iidaka Toshiko , Asai Yoshiki , Oka Hiroyuki , Muraki Shigeyuki , Akune Toru , Kawaguchi Hiroshi , Nakamura Kozo , Yoshida Munehito , Tanaka Sakae , Yoshimura Noriko , Yamada Hiroshi 
Published: July 2022

AbstractThe relationship between acetabular dysplasia and spino-pelvic alignment remains unclear. The aim of this study was to clarify the association between acetabular dysplasia and spino-pelvic alignment, based on a large-scale population-based cohort in Japan. From the third survey of the Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study, 1,481 participants (491 men and 990 women; mean age, 65.3 years) were analyzed. Center-edge (CE) angle and spino-pelvic parameters (lumbar lordosis, LL; sacral slope, SS; pelvic tilt, PT; pelvic incidence, PI) were measured radiographically. Acetabular dysplasia was defined as a CE angle < 20°, and associations between acetabular dysplasia and spino-pelvic parameters were assessed. The group with acetabular dysplasia had significantly higher age, higher percentage of female, higher SS and higher PI than the group without acetabular dysplasia in a univariate analysis. On the other hand, acetabular dysplasia was not significantly associated with spino-pelvic parameters in a multiple logistic regression analysis that include age, sex, SS and PI as explanatory variables; however, PI demonstrated a positive odds ratio (odds ratio, 1.02; 95% CI 1.00–1.04). In conclusion, acetabular dysplasia was not significantly associated with spino-pelvic parameters, but higher PI may be an associated factor for acetabular dysplasia.
Association of circulating gene expression signatures with stiffness following total knee arthroplasty for osteoarthritis: a pilot study
Authors: Kirksey Meghan A. , Lessard Samantha G. , Khan Marjan , Birch George A. , Oliver David , Singh Purva , Rotundo Valeria , Sideris Alexandra ,   TKAF Consortium, Pannellini Tania , Nocon Allina A. , Youseff Mark , Guirguis Paul , Bauer Thomas W. , Bogner Eric A. , Bostrom Mathias P. , Haas Steven B. , Jules-Elysee Kethy M. , Figgie Mark P. , Mayman David J. , McLawhorn Alexander S. , Cross Michael B. , Padgett Douglas E. , Pernis Alessandra B. , Rodeo Scott A. , Tam Kathleen , Westrich Geoffrey H. , Potter Hollis G. , Koff Matthew F. , Ivashkiv Lionel B. , Sculco Thomas P. , Wright Timothy M. , Gonzalez Della Valle Alejandro , Parks Michael L. , Sculco Peter K. , Otero Miguel 
Published: July 2022

AbstractA subset of patients undergoing total knee arthroplasty (TKA) for knee osteoarthritis develop debilitating knee stiffness (reduced range of motion) for poorly understood reasons. Dysregulated inflammatory and immune responses to surgery correlate with reduced surgical outcomes, but the dysregulated gene signatures in patients with stiffness after TKA are poorly defined. As a consequence, we are limited in our ability to identify patients at risk of developing poor surgical outcomes and develop preventative approaches. In this pilot study we aimed to identify perioperative blood gene signatures in patients undergoing TKA for knee osteoarthritis and its association with early surgical outcomes, specifically knee range of motion. To do this, we integrated clinical outcomes collected at 6 weeks after surgery with transcriptomics analyses in blood samples collected immediately before surgery and at 24 h after surgery. We found that patients with stiffness at 6 weeks after surgery have a more variable and attenuated circulating gene expression response immediately after surgery. Our results suggest that patients with stiffness following TKA may have distinct gene expression signatures detectable in peripheral blood in the immediate postoperative period.
Gut microbiota plasticity in insular lizards under reversed island syndrome
Authors: Buglione Maria , Ricca Ezio , Petrelli Simona , Baccigalupi Loredana , Troiano Claudia , Saggese Anella , Rivieccio Eleonora , Fulgione Domenico 
Published: July 2022

AbstractAnimals living on small islands are more drastically exposed to environmental changes, such as food or water starvation, and rapid temperature shifts. Facing such conditions, and probably thank to adaptive plasticity mechanisms, some animals display a Reversed Island Syndrome (RIS), a suite of traits, including skin pigmentation, voracity, sexual dimorphism, showed differently from mainland relatives. Here, we analyse a so far poorly explored aspect of RIS: the effect of this on the microbiota composition of host Italian wall lizard (Podarcis siculus), strongly influenced by the animal’s lifestyle, and conditioning the same. We compare mainland and island populations, assessing the difference between their microbial communities and their response under unexpected food, experimentally provided. Our observations showed a significant difference in microbiota communities between island and mainland groups, depended mainly from changes in relative abundance of the shared genera (difference due to decrease/increase). Exposure to experimental diet regimes resulted into significative reshaping of bacterial composition of microbiota and a greater variation in body mass only in the island population. Our results could be an evidence that gut microbial community contributes to adaptive plasticity mechanisms of island lizards under RIS to efficiently respond to unexpected changes.
MYPT1 reduction is a pathogenic factor of erectile dysfunction
Authors: Zhao Wei , Sun Jie , Yao Liang-Yu , Hang Dong , Li Ye-Qiong , Chen Cai-Ping , Zhou Yu-Wei , Chen Xin , Tao Tao , Wei Li-Sha , Zheng Yan-Yan , Ge Xie , Li Chao-Jun , Xin Zhong-Cheng , Pan Yang , Wang Xin-Zhu , He Wei-Qi , Zhang Xue-Na , Yao Bing , Zhu Min-Sheng 
Published: July 2022

AbstractErectile dysfunction (ED) is closely associated with smooth muscle dysfunction, but its underlying mechanisms remains incompletely understood. We here reported that the reduced expression of myosin phosphatase target subunit 1 (MYPT1), the main regulatory unit of myosin light chain phosphatase, was critical for the development of vasculogenic ED. Male MYPT1 knockout mice had reduced fertility and the penises displayed impaired erections as evidenced by reduced intracavernous pressure (ICP). The penile smooth muscles of the knockout mice displayed enhanced response to G-Protein Couple Receptor agonism and depolarization contractility and resistant relaxation. We further identified a natural compound lotusine that increased the MYPT1 expression by inhibiting SIAH1/2 E3 ligases-mediated protein degradation. This compound sufficiently restored the ICP and improved histological characters of the penile artery of Mypt1 haploinsufficiency mice. In diabetic ED mice (db/db), the decreased expression of MYPT1 was measured, and ICP was improved by lotusine treatment. We conclude that the reduction of MYPT1 is the major pathogenic factor of vasculogenic ED. The restoration of MYPT1 by lotusine improved the function of injured penile smooth muscles, and could be a novel strategy for ED therapy.
Adiabatic state preparation of correlated wave functions with nonlinear scheduling functions and broken-symmetry wave functions
Authors: Sugisaki Kenji , Toyota Kazuo , Sato Kazunobu , Shiomi Daisuke , Takui Takeji 
Published: July 2022

AbstractAdiabatic state preparation (ASP) can generate the correlated wave function by simulating the time evolution of wave function under the time-dependent Hamiltonian that interpolates the Fock operator and the full electronic Hamiltonian. However, ASP is inherently unsuitable for studying strongly correlated systems, and furthermore practical computational conditions for ASP are unknown. In quest for the suitable computational conditions for practical applications of ASP, we performed numerical simulations of ASP in the potential energy curves of N2, BeH2, and in the C2v quasi-reaction pathway of the Be atom insertion to the H2 molecule, examining the effect of nonlinear scheduling functions and the ASP with broken-symmetry wave functions with the S2 operator as the penalty term, contributing to practical applications of quantum computing to quantum chemistry. Eventually, computational guidelines to generate the correlated wave functions having the square overlap with the complete-active space self-consistent field wave function close to unity are discussed.
Modelling the impact of Omicron and emerging variants on SARS-CoV-2 transmission and public health burden
Authors: Le Rutte Epke A. , Shattock Andrew J. , Chitnis Nakul , Kelly Sherrie L. , Penny Melissa A. 
Published: July 2022

Abstract
Background
SARS-CoV-2 variants of concern, such as Omicron (B.1.1.529), continue to emerge. Assessing the impact of their potential viral properties on the probability of future transmission dominance and public health burden is fundamental in guiding ongoing COVID-19 control strategies.

Methods
With an individual-based transmission model, OpenCOVID, we simulated three viral properties; infectivity, severity, and immune-evading ability, all relative to the Delta variant, to identify thresholds for Omicron’s or any emerging VOC’s potential future dominance, impact on public health, and risk to health systems. We further identify for which combinations of viral properties current interventions would be sufficient to control transmission.

Results
We show that, with first-generation SARS-CoV-2 vaccines and limited physical distancing in place, a VOC’s potential future dominance is primarily driven by its infectivity, which does not always lead to an increased public health burden. However, we also show that highly immune-evading variants that become dominant, even in the case of reduced variant severity, would likely require alternative measures to avoid strain on health systems, such as strengthened physical distancing measures, novel treatments, and second-generation vaccines. Expanded vaccination, that includes a booster dose for adults and child vaccination strategies, is projected to have the biggest public health benefit for a highly infective, highly severe VOC with low immune-evading capacity.

Conclusions
These findings provide quantitative guidance to decision-makers at a critical time while Omicron’s properties are being assessed and preparedness for emerging VOCs is eminent. We emphasise the importance of both genomic and population epidemiological surveillance.
Masked Speech Recognition as a Function of Masker Location for Cochlear Implant Users With Single-Sided Deafness
Authors: Anderson Kelly M. , Buss Emily , Rooth Meredith A. , Richter Margaret E. , Overton Andrea B. , Brown Kevin D. , Dillon Margaret T. 
Published: July 2022

Purpose:
Cochlear implant (CI) recipients with normal or near normal hearing (NH) in the contralateral ear, referred to as single-sided deafness (SSD), experience significantly better speech recognition in noise with their CI than without it, although reported outcomes vary. One possible explanation for differences in outcomes across studies could be differences in the spatial configurations used to assess performance. This study compared speech recognition for different spatial configurations of the target and masker, with test materials used clinically.

Method:
Sixteen CI users with SSD completed tasks of masked speech recognition presented in five spatial configurations. The target speech was presented from the front speaker (0° azimuth). The masker was located either 90° or 45° toward the CI-ear or NH-ear or colocated with the target. Materials were the AzBio sentences in a 10-talker masker and the Bamford-Kowal-Bench Speech-in-Noise test (BKB-SIN; four-talker masker). Spatial release from masking (SRM) was computed as the benefit associated with spatial separation relative to the colocated condition.

Results:
Performance was significantly better when the masker was separated toward the CI-ear as compared to colocated. No benefit was observed for spatial separations toward the NH-ear. The magnitude of SRM for spatial separations toward the CI-ear was similar for 45° and 90° when tested with the AzBio sentences, but a larger benefit was observed for 90° as compared to 45° for the BKB-SIN.

Conclusions:
Masked speech recognition in CI users with SSD varies as a function of the spatial configuration of the target and masker. Results supported an expansion of the clinical test battery at the study site to assess binaural hearing abilities for CI candidates and recipients with SSD. The revised test battery presents the target from the front speaker and the masker colocated with the target, 90° toward the CI-ear, or 90° toward the NH-ear.
A sample‐proxy dual triplet loss function for object re‐identification
Authors: Wu Hanxiao , Shen Fei , Zhu Jianqing , Zeng Huanqiang , Zhu Xiaobin , Lei Zhen 
Published: July 2022

AbstractObject re‐identification, such as vehicle re‐identification or pedestrian re‐identification, plays a significant role in intelligent video surveillance systems for public security. Due to viewpoint variations and appearance changes, both pedestrians and vehicles usually have complex intra‐class variations. However, most existing object re‐identification methods often use a sample‐level triplet loss function cooperating with a single‐proxy softmax loss function, which could not handle complex intra‐class variations well. In this paper, a sample‐proxy dual triplet (SPDT) loss function is proposed, which works with a multi‐proxy softmax (MPS) loss function. The MPS loss function is in charge of learning multiple proxies to represent a class. The SPDT loss function is responsible for enlarging inter‐class distances as well as shrinking intra‐class distances on both sample and proxy levels. Therefore, the method not only handles multi‐proxy intra‐class variations but also fully learns discrimination on samples and proxies. Experiments on two large datasets, that is, VeRi776 and DukeMTMC‐reID, demonstrate that the method is superior to state‐of‐the‐art object re‐identification approaches.
Accretion flows around exotic tidal wormholes
Authors: Sokoliuk O. , Praharaj S. , Baransky A. , Sahoo P. K. 
Published: July 2022

Aims. This paper investigates the various spherically symmetric wormhole solutions in the presence of tidal forces and applies numerous methods, such as test particle orbital dynamics, ray-tracing, and microlensing.
Methods. We make theoretical predictions on the test particle orbital motion around the tidal wormholes with the use of the effective potential normalized by ℒ2. In order to obtain the ray-tracing images of both geometrically thin and thick accretion disks and relativistic jets, we modified the open source GYOTO code using a python interface.
Results. We applied this technique to probe the accretion flows near Schwarzschild-like and charged Reissner-Nordström (RN) wormholes; we assumed both a charged RN wormhole and a special case with a vanishing electromagnetic charge, namely the Damour-Solodukhin (DS) wormhole. We show that the photon sphere for the Schwarzschild-like wormhole present for both thin and thick accretion disks, even for the vanishing tidal forces. Moreover, we observe that rph → ∞ as α → ∞, which constraints the α parameter to be sufficiently small and positive in order to respect Event Horizon Telescope observations. On the other hand, for the case of the RN wormhole, the photon sphere radius shrinks as Λ → ∞, as predicted by the effective potential. In addition to the accretion disks, we also probe the relativistic jets around the two wormhole solutions under consideration. Finally, with the help of star bulb microlensing, we approximate the radius of the wormhole shadow and find that for the Schwarzschild wormhole, RSh ≈ r0 for zero tidal forces and grows linearly with α. On the contrary, the shadow radius for charged wormholes slowly decreases with the growing DS parameter, Λ.
Repenser les valeurs attribuées au sport au Maroc : les limites d’une croyance sportive collective
Authors: Benkorti Aziz 
Published: July 2022

À travers une enquête sociologique qualitative, croisant entretiens compréhensifs et observations, le présent article interroge la croyance en un sport perçu comme « naturellement » éducatif et inclusif au Maroc. L’analyse des données recueillies auprès d’un groupe de jeunes sportifs, de leurs parents et des associations sportives dans deux quartiers défavorisés de la ville de Témara (Maroc) met en évidence les limites, voire les paradoxes, de cette croyance face aux contraintes et aux ressources déterminées socialement de la population des quartiers défavorisés. Ainsi, les résultats permettent, d’une part, de déconstruire cette croyance tout en contribuant, d’autre part, à repenser les vertus attribuées au sport en prenant en compte les difficultés et les besoins de la population ciblée.
Indirect x-ray photodesorption of N215 and CO13 from mixed and layered ices
Authors: Basalgète R. , Torres-Díaz D. , Lafosse A. , Amiaud L. , Féraud G. , Jeseck P. , Philippe L. , Michaut X. , Fillion J.-H. , Bertin M. 
Published: July 2022

X-ray photodesorption yields of N215 and CO13 are derived as a function of the incident photon energy near the N (∼400 eV) and O K-edge (∼500 eV) for pure N215 ice and mixed CO13:N215 ices. The photodesorption spectra from the mixed ices reveal an indirect desorption mechanism for which the desorption of N215 and CO13 is triggered by the photoabsorption of CO13 and N215, respectively. This mechanism is confirmed by the x-ray photodesorption of CO13 from a layered CO13/N215 ice irradiated at 401 eV on the N 1s → π* transition of N215. This latter experiment enables us to quantify the relevant depth involved in the indirect desorption process, which is found to be 30–40 monolayers in that case. This value is further related to the energy transport of Auger electrons emitted from the photoabsorbing N215 molecules that scatter toward the ice surface, inducing the desorption of CO13. The photodesorption yields corrected from the energy that can participate in the desorption process (expressed in molecules desorbed by eV deposited) do not depend on the photon energy; hence, they depend neither on the photoabsorbing molecule nor on its state after Auger decay. This demonstrates that x-ray induced electron stimulated desorption, mediated by Auger scattering, is the dominant process explaining the desorption of N215 and CO13 from the ices studied in this work.
Crystal structure of the Ate1 arginyl-tRNA-protein transferase and arginylation of N-degron substrates
Authors: Kim Bong Heon , Kim Min Kyung , Oh Sun Joo , Nguyen Kha The , Kim Jun Hoe , Varshavsky Alexander , Hwang Cheol-Sang , Song Hyun Kyu 
Published: July 2022

N-degron pathways are proteolytic systems that target proteins bearing N-terminal (Nt) degradation signals (degrons) called N-degrons. Nt-Arg of a protein is among Nt-residues that can be recognized as destabilizing ones by the Arg/N-degron pathway. A proteolytic cleavage of a protein can generate Arg at the N terminus of a resulting C-terminal (Ct) fragment either directly or after Nt-arginylation of that Ct-fragment by the Ate1 arginyl-tRNA-protein transferase (R-transferase), which uses Arg-tRNAArgas a cosubstrate. Ate1 can Nt-arginylate Nt-Asp, Nt-Glu, and oxidized Nt-Cys* (Cys-sulfinate or Cys-sulfonate) of proteins or short peptides.Ate1genes of fungi, animals, and plants have been cloned decades ago, but a three-dimensional structure of Ate1 remained unknown. A detailed mechanism of arginylation is unknown as well. We describe here the crystal structure of the Ate1 R-transferase from the budding yeastKluyveromyces lactis. The 58-kDa R-transferase comprises two domains that recognize, together, an acidic Nt-residue of an acceptor substrate, the Arg residue of Arg-tRNAArg, and a 3′-proximal segment of the tRNAArgmoiety. The enzyme’s active site is located, at least in part, between the two domains. In vitro and in vivo arginylation assays with site-directed Ate1 mutants that were suggested by structural results yielded inferences about specific binding sites of Ate1. We also analyzed the inhibition of Nt-arginylation activity of Ate1 by hemin (Fe3+-heme), and found that hemin induced the previously undescribed disulfide-mediated oligomerization of Ate1. Together, these results advance the understanding of R-transferase and the Arg/N-degron pathway.
Formation of bound states from the edge states of 2D topological insulator by macroscopic magnetic barriers
Authors: Khomitsky D V , Konakov A A , Lavrukhina E A 
Published: July 2022

Abstract
A model of bound state formation from the delocalized edge states of 2D topological insulator (TI) is derived by considering the effects of magnetic barriers attached to the edge of the HgTe/CdTe quantum well. The resulting structure has a spatial form of 1D quantum dot (QD) with variable number of bound states depending on barrier parameters. The spatial profile of exchange interaction between the edge states and barriers is derived from the interaction with single impurity magnetic moment and is generalized for the barrier bulk structure formed by ensemble of impurities. The resulting Hamiltonian is studied as a function of barrier parameters including their strength and orientation of the magnetic moments. It is shown that for parallel magnetization of two barriers at least two discrete levels are formed regardless of the barrier strength. For antiparallel magnetization at least a single bound state is formed for any strength of the barriers. Our results may help in design of novel types of QDs based on TIs.