bluuebunny/crossref_metadata_2025_split huggingface dataset:
Graphene Oxide Nanoscale Platform Enhances the Anti‐Cancer Properties of Bortezomib in Glioblastoma Models
Authors: Sharp Paul S. , Stylianou Maria , Arellano Luis M. , Neves Juliana C. , Gravagnuolo Alfredo M. , Dodd Abbie , Barr Katharine , Lozano Neus , Kisby Thomas , Kostarelos Kostas 
Published: October 2022

AbstractGraphene‐based 2D nanomaterials possess unique physicochemical characteristics which can be utilized in various biomedical applications, including the transport and presentation of chemotherapeutic agents. In glioblastoma multiforme (GBM), intratumorally administered thin graphene oxide (GO) nanosheets demonstrate a widespread distribution throughout the tumor volume without impact on tumor growth, nor spread into normal brain tissue. Such intratumoral localization and distribution can offer multiple opportunities for treatment and modulation of the GBM microenvironment. Here, the kinetics of GO nanosheet distribution in orthotopic GBM mouse models is described and a novel nano‐chemotherapeutic approach utilizing thin GO sheets as platforms to non‐covalently complex a proteasome inhibitor, bortezomib (BTZ), is rationally designed. Through the characterization of the GO:BTZ complexes, a high loading capacity of the small molecule on the GO surface with sustained BTZ biological activity in vitro is demonstrated. In vivo, a single low‐volume intratumoral administration of GO:BTZ complex shows an enhanced cytotoxic effect compared to free drug in two orthotopic GBM mouse models. This study provides evidence of the potential that thin and small GO sheets hold as flat nanoscale platforms for GBM treatment by increasing the bioavailable drug concentration locally, leading to an enhanced therapeutic effect.
Stress Relaxation‐Induced Colon Tumor Multicellular Spheroid Culture Based on Biomimetic Hydrogel for Nanoenzyme Ferroptosis Sensitization Evaluation
Authors: Zhang Yi , Peng Liyi , Hu Ke , Gu Ning 
Published: October 2022

AbstractFerroptosis has recently become a research hotspot, and the induction of tumor cell ferroptosis has emerged as a powerful method for tumor therapy. However, the efficiency of tumor cell ferroptosis induction remains unmet for clinical use, which may be attributed to the large discrepancies between in vitro and in vivo models. To address this issue, in this study, a hydrogel platform with stress relaxation is utilized to develop a multicellular spheroid model of the DLD1 colon cancer cell line through cancer cell self‐organization. The spheroids are highly similar to real tumor tissue, and ferroptosis resistance at the transcriptional, protein, and cellular levels. Collaboration of the ferroptosis induction reagent erastin and the nanoenzyme MnZnFe2O4@PEG‐COOH to overcome the ferroptosis resistance of the spheroids is also demonstrated. Taken together, this study demonstrates the effectiveness of the model developed using this hydrogel platform for further mechanistic studies, and for the assessment of novel cancer treatment strategies based on ferroptosis.
Emergent, Non‐Aging, Extendable, and Rechargeable Exchange Bias in 2D Fe3GeTe2 Homostructures Induced by Moderate Pressuring
Authors: Liu Caixing , Zhang Huisheng , Zhang Shunhong , Hou De , Liu Yonglai , Wu Hanqing , Jiang Zhongzhu , Wang HuaiXiang , Ma Zongwei , Luo Xuan , Li Xiaoyin , Sun Yuping , Xu Xiaohong , Zhang Zhenyu , Sheng Zhigao 
Published: October 2022

AbstractAs a crucial concept in magnetism and spintronics, exchange bias (ExB) measures the asymmetry in the hysteresis loop of a pinned ferromagnet (FM)/antiferromagnet (AFM) interface. Previous studies are mainly focused on FM/AFM heterostructures composed of conventional bulk materials, whose complex interfaces prohibit precise control and full understanding of the phenomenon. Here, the enabling power of 2D magnets is exploited to demonstrate the emergence, non‐aging, extendability, and rechargeability of ExB in van der Waals Fe3GeTe2 homostructures, upon moderate pressuring. The emergence of the ExB is attributed to a local stress‐induced FM‐to‐AFM transition, as validated using first‐principles calculations, and confirmed in magneto‐optical Kerr effect and second harmonic generation measurements. It is also observed that, negligible ExB aging before the training effect suddenly takes place through avalanching, pronounced delay of the avalanche via timed pressure repetition (extendability), ExB recovery in the post‐training sample upon refreshed pressuring (rechargeability), and demonstrate its versatile tunability. These striking findings offer unprecedented insights into the underlying principles of ExB and its training, with immense technological applications in sight.
Long‐Life Regenerated LiFePO4 from Spent Cathode by Elevating the d‐Band Center of Fe
Authors: Jia Kai , Ma Jun , Wang Junxiong , Liang Zheng , Ji Guanjun , Piao Zhihong , Gao Runhua , Zhu Yanfei , Zhuang Zhaofeng , Zhou Guangmin , Cheng Hui‐Ming 
Published: October 2022

AbstractA large amount of spent LiFePO4 (LFP) has been produced in recent years because it is one of the most widely used cathode materials for electric vehicles. The traditional hydrometallurgical and pyrometallurgical recycling methods are doubted because of the economic and environmental benefits; the direct regeneration method is considered a promising way to recycle spent LFP. However, the performance of regenerated LFP by direct recycling is not ideal due to the migration of Fe ions during cycling and irreversible phase transition caused by sluggish Li+ diffusion. The key to addressing the challenge is to immobilize Fe atoms in the lattice and improve the Li+ migration capability during cycling. In this work, spent LFP is regenerated by using environmentally friendly ethanol, and its cycling stability is promoted by elevating the d‐band center of Fe atoms via construction of a heterogeneous interface between LFP and nitrogen‐doped carbon. The FeO bonding is strengthened and the migration of Fe ions during cycling is suppressed due to the elevated d‐band center. The Li+ diffusion kinetics in the regenerated LFP are improved, leading to an excellent reversibility of the phase transition. Therefore, the regenerated LFP exhibits an ultrastable cycling performance at a high rate of 10 C with ≈80% capacity retention after 1000 cycles.
All‐Liquid Reconfigurable Electronics Using Jammed MXene Interfaces
Authors: Popple Derek , Shekhirev Mikhail , Dai Chunhui , Kim Paul , Wang Katherine Xiaoxin , Ashby Paul , Helms Brett A. , Gogotsi Yury , Russell Thomas P. , Zettl Alex 
Published: October 2022

AbstractRigid, solid‐state components represent the current paradigm for electronic systems, but they lack post‐production reconfigurability and pose ever‐increasing challenges to efficient end‐of‐life recycling. Liquid electronics may overcome these limitations by offering flexible in‐the‐field redesign and separation at end‐of‐life via simple liquid phase chemistries. Up to now, preliminary work on liquid electronics has focused on liquid metal components, but these devices still require an encapsulating polymer and typically use alloys of rare elements like indium. Here, using the self‐assembly of jammed 2D titanium carbide (Ti3C2Tx) MXene nanoparticles at liquid–liquid interfaces, “all‐liquid” electrically conductive sheets, wires, and simple functional devices are described including electromechanical switches and photodetectors. These assemblies combine the high conductivity of MXene nanosheets with the controllable form and reconfigurability of structured liquids. Such configurations can have applications not only in electronics, but also in catalysis and microfluidics, especially in systems where the product and substrate have affinity for solvents of differing polarity.
“Enzyme‐Like” Spatially Fixed Polyhydroxyl Microenvironment‐Activated Hydrochromic Molecular Switching for Naked Eye Detection of ppm Level Humidity
Authors: Wei Xiaoyan , Zhang Sean Xiao‐An , Sheng Lan 
Published: October 2022

AbstractThe detection and monitoring of ultralow humidity (<100 ppm) are critical in many important industries, such as high‐tech manufacturing, scientific research, and aerospace. However, the development of ppm level humidity sensors with portability, low cost, and ease of regeneration remains a significant challenge. Herein, an innovative “enzyme‐like” construction strategy is proposed to address this problem by employing suitable molecular‐level humidity‐sensitive units and chemically constructing a multilevel spatial synergistic sensitization microenvironment around it. The as‐prepared ultralow humidity‐sensitive paper (UHSP) achieved a naked eye recognition humidity of 0.01–100 ppm. UHSP not only is simple to prepare, handy and low‐cost, but can also be simply and efficiently regenerated as well as recycled many times by skillfully utilizing the “unconventional sublimation” and “lime slaked” of calcium oxide. The molecular reaction mechanisms involved in the humidity response and regeneration of UHSP have been demonstrated in detail. UHSP can provide a promising new method for ultralow humidity detection in the form of portable kits or sirens. The demonstrated “enzyme‐like” construction strategy can bring unlimited ideas and implications to the design and development of sensors with tunable response thresholds, particularly high sensitivity.
Phosphorous Dendron Micelles as a Nanomedicine Platform for Cooperative Tumor Chemoimmunotherapy via Synergistic Modulation of Immune Cells
Authors: Zhan Mengsi , Qiu Jieru , Fan Yu , Chen Liang , Guo Yunqi , Wang Zhiqiang , Li Jin , Majoral Jean‐Pierre , Shi Xiangyang 
Published: October 2022

AbstractDesign of effective nanomedicines to modulate multiple immune cells to overcome the immune‐suppressive tumor microenvironment is desirable to improve the overall poor clinical outcomes of immunotherapy. Herein, a nanomedicine platform is reported based on chemotherapeutic drug doxorubicin (DOX)‐loaded phosphorus dendron micelles (M‐G1‐TBPNa@DOX, TBP, tyramine bearing two dimethylphosphonate) with inherent immunomodulatory activity for synergistic tumor chemoimmunotherapy. The M‐G1‐TBPNa@DOX micelles with good stability and a mean particle size of 86.4 nm can deliver DOX to solid tumors to induce significant tumor cell apoptosis and immunogenic cell death (ICD). With the demonstrated intrinsic activity of M‐G1‐TBPNa that can promote the proliferation of natural killer (NK) cells, the ICD‐resulted maturation of dendritic cells of the DOX‐loaded micelles, and the combination of anti‐PD‐L1 antibody, the synergistic modulation of multiple immune cells through NK cell proliferation, recruitment of tumor‐infiltrating NK cells and cytotoxic T cells, and decrease of regulatory T cells for effective tumor chemoimmunotherapy with strong antitumor immunity and immune memory effect for effective prevention of lung metastasis are demonstrated. The developed phosphorous dendron micelles may hold great promise to be used as an advanced nanomedicine formulation for synergistic modulation of multiple immune cells through NK cell proliferation for effective chemoimmunotherapy of different tumor types.
Recent Developments of Inkjet‐Printed Flexible Energy Storage Devices
Authors: Li Chun , Bu Fan , Wang Qiangzheng , Liu Xiangye 
Published: October 2022

AbstractWith the rapid development of portable and wearable electronics, the design and fabrication of flexible electrochemical energy storage devices, including batteries and supercapacitors, have attracted tremendous attention among both scientific and industrial fields. Inkjet printing is considered to be a promising technology for manufacturing low‐cost high‐performance flexible energy storage devices because of its material‐saving feature and pattern‐writing flexibility. Very recently, great efforts have been dedicated to adapting inkjet printing for the production of practical flexible energy storage devices. In this review, inkjet printing operation mechanisms, ink properties, and the interaction between the droplet and substrate are first described in detail. Then the development of inkjet‐printed flexible electrochemical energy storage devices in recent years is focused on from the perspective of electrode materials. Next, the application of inkjet‐printed flexible energy storage devices in self‐powered electronic systems is briefly introduced. At last, challenges and future development directions of inkjet‐printed flexible energy storage devices are further discussed.
Analysis of Carrier Transport in Quantum Dot/Metal‐Oxide Phototransistors via Light‐Mediated Interfacial Modeling
Authors: Park Joon Bee , Kim Jaehyun , Jang Young Woo , Park Hun‐Bum , Yang Seong Hwan , Kim Dae‐Hwan , Kim Myunggil , Facchetti Antonio , Park Sung Kyu 
Published: October 2022

AbstractQuantum dot (QD) hybrid phototransistors based on high‐mobility channel semiconductors have attracted great interest due to their outstanding photonic characteristics with diverse and broadband optoelectronic functionalities. However, difficulties for precise control of electronic coupling between QD particles and lack of QD/semiconductor interface analysis have limited the use of these platforms into practical optoelectronic applications. Here, the authors report a new strategy to high‐performance phototransistors based on CdSe QD/amorphous oxide semiconductor heterostructures using trap‐reduced chelating chalcometallate surface ligands by optimizing the QD layer thickness and interface engineering to enhance photogenerated charge transfer properties. Furthermore, based on performance parameters extracted from experimental structure and electrical characteristics, Technology Computer‐Aided Design (TCAD) modeling reveals carrier flow between the QDs in the semiconductor layer in agreement with various spectroscopic data. These modeling results indicate that interface engineering of QD with chalcometallate ligand results in very efficient photo‐induced charge transfer characteristics. Thus, high‐performance chalcometallate ligand QD‐based phototransistors are successfully realized with enhanced responsivity (2.12 × 104 A W−1) and photodetectivity (2.74 × 1016 Jones) compared with conventional monodentate ligand functionalized (SCN−) QD‐based devices (8.79 × 103 A W−1 and 8.8 × 1010 Jones, respectively). This is the demonstration of systematic analysis of QD‐based hetero‐structured phototransistors with light‐mediated interfacial physical modeling and electrochemical measurement.
Eco‐Friendly Transition‐Metal‐Ion‐Doped rGO Nanocomposites with Enhanced Photocatalytic Activities
Authors: Pham Vy Ngoc , Jeon Hyeri , Han Seoyoung , Hong Seungwoo , Lee Hangil 
Published: October 2022

AbstractImproving the photocatalytic properties of various types of metal oxides is becoming increasingly important in terms of environmental factors. Carbon allotropes are eco‐friendly materials, and improving their photocatalytic properties via doping‐induced modifications is one of the most attractive research areas. In this context, various first‐row transition‐metal‐ion‐doped reduced graphene oxide samples are synthesized and characterized using high‐resolution transmission electron microscopy along with X‐ray absorption spectroscopy to investigate their morphological and electronic structures at the molecular level. Transition metal‐ion doping produces several defect structures at the oxygen functionalities of reduced graphene oxide nanocomposites (rGO). Such defect structures are well correlated with their photocatalytic activity; Cr@rGO and Fe@rGO exhibit decent activities among the four tested rGO samples in the photocatalytic degradation of organic pollutants and selective oxidation of 2,5‐hydroxymethylfurfural. To test the environmental factors, cytotoxicity tests are performed by incubating the modified rGO with human skin cells; Fe@rGO is found to be the least toxic. Therefore, Fe@rGO displayed both enhanced photocatalytic activity and environment‐friendly character as compared to the bare rGO, indicating that it is a plausible candidate for application in the petrochemical transformation of biomass without environmental concerns.
A Solid Oxide Fuel Cell Runs on Hydrocarbon Fuels with Exceptional Durability and Power Output
Authors: Zhang Weilin , Hu Xueyu , Zhou Yucun , Luo Zheyu , Nam Gyutae , Ding Yong , Li Tongtong , Liu Zhijun , Ahn Yoojin , Kane Nicholas , Wang Weining , Hou Jie , Spradling Drew , Liu Meilin 
Published: October 2022

AbstractSolid oxide fuel cells (SOFCs) that can operate on hydrocarbon fuels offer an efficient and cost‐effective solution for electricity generation. However, broader commercialization of SOFCs is hindered by inadequate performance and limited durability due to the sluggish hydrocarbon reforming/oxidation kinetics and coking on the SOFC anode. Here it has been reported that these findings in design, synthesis, and characterization of a novel anode catalyst Ba(Zr0.8Y0.2)0.9(Ni0.5Ru0.5)0.1O3‐δ (BZYNR) that overcomes the problems, enabling direct utilization of nearly dry hydrocarbon fuels (e.g., methane, ethanol, and iso‐octane with only 3 vol% H2O) with exceptional power output for over 1000 h on both button cells and tubular cells. The outstanding performance of BZYNR is attributed to the high activity of hydrocarbon reforming and the accelerated water‐mediated carbon cleaning process on Ni‐based SOFC anode.
Recent Advances in Molecular Oxygen Assisted Laccase Catalyzed Sustainable Organic Transformations
Authors: Jayakumar Jyothylakshmi , Priyadarshini Deepshikha , Parthasarathy Anutthaman , Reddy Sabbasani Rajasekhara 
Published: October 2022

AbstractBio‐catalysis is a versatile and powerful tool in organic synthesis, hazardous chemical remediation, biosensors, and industrial sectors. It has been claimed that laccases can function as an intriguing class of biocatalyst in organic chemistry. They are highly favourable catalysts and offer advantages over conventional oxidants and toxic metal catalysts by exhibiting high activity in aqueous media under mild conditions and also work on diverse functional groups possessing substrates maintaining the atom economy. They coordinate well with molecular oxygen and perform chemo selective oxidation reactions, as well as a plethora of other reactions. However, this review is intended to cover molecular oxygen‐assisted laccase catalysis in organic transformations and its significance in industry.
π‐Expanded Carbazoles as Hole‐Selective Self‐Assembled Monolayers for High‐Performance Perovskite Solar Cells
Authors: Jiang Wenlin , Li Fengzhu , Li Mingliang , Qi Feng , Lin Francis R. , Jen Alex K.‐Y. 
Published: October 2022

AbstractCarbazole‐derived self‐assembled monolayers (SAMs) are promising hole‐selective materials for inverted perovskite solar cells (PSCs). However, they often possess small dipoles which prohibit them from effectively modulating the workfunction of ITO substrate, limiting the PSC photovoltage. Moreover, their properties can be drastically affected by even subtle structural modifications, undermining the final PSC performance. Here, we designed two carbazole‐derived SAMs, CbzPh and CbzNaph through asymmetric or helical π‐expansion for improved molecular dipole moment and strengthened π‐π interaction. The helical π‐expanded CbzNaph has the largest dipole, forming densely packed and ordered monolayer, facilitated by the highly ordered assembly observed in its π‐scaffold's single crystal. These synergistically modulate the perovskite crystallization atop and tune the ITO workfunction. Consequently, the champion PSC employing CbzNaph showed an excellent 24.1 % efficiency and improved stability.
Highly Oxidation‐Resistant Electrolyte for 4.7 V Sodium Metal Batteries Enabled by Anion/Cation Solvation Engineering
Authors: Wu Daxiong , Zhu Chunlei , Wu Mingguang , Wang Huaping , Huang Junda , Tang Dongliang , Ma Jianmin 
Published: October 2022

AbstractSodium metal batteries (SMBs) are considered as promising battery system due to abundant Na sources. However, poor compatibility between electrolyte and cathode severely impedes its development. Herein, we proposed an anion/cation solvation strategy for realizing 4.7 V resistant SMBs electrolyte with NaClO4 and trimethoxy(pentafluorophenyl)silane (TPFS) as dual additives (DA). The ClO4− can rapidly transfer to the cathode surface and strongly coordinate with Na+ to form stable polymer‐like chains with solvents. Meanwhile, TPFS can preferentially enter into the PF6− anion solvation sheath for reducing PF6‐solvent interaction and effectively scavenge adverse electrolyte species for protecting electrode electrolyte interphases. Thus, such electrolyte elevates the oxidative stability of carbonate electrolytes from 3.77 to 4.75 V, and enables Na||Na3V2(PO4)2O2F (NVPF) battery with a capacity retention of 93 % and an average Coulombic efficiency (CE) of 99.6 % after 500 cycles at 4.7 V.
Compacting Electric Double Layer Enables Carbon Electrode with Ultrahigh Zn Ion Storage Capability
Authors: Shi Xin , Xie Jinhao , Yang Fan , Wang Fuxin , Zheng Dezhou , Cao Xianshuo , Yu Yanxia , Liu Qi , Lu Xihong 
Published: October 2022

AbstractCarbon‐based cathodes for aqueous zinc ion hybrid supercapacitors (ZHSCs) typically undergo low Zn ion storage capability due to their electric double layer capacitance (EDLC) energy storage mechanism that is restricted by specific surface area and thickness of electric double layer (EDL). Here, we report a universal surface charge modulation strategy to effectively enhance the capacitance of carbon materials by decreasing the thickness of EDL. Amino groups with lone pair electrons were chosen to increase the surface charge density and enhanced the interaction between carbon electrode and Zn ions, thus effectively compacting the EDL. Consequently, amino functionalized porous carbon based ZHSCs can deliver an ultrahigh capacity of 255.2 mAh g−1 along with excellent cycling stability (95.5 % capacity retention after 50 000 cycles) in 1 M ZnCl2 electrolyte. This study demonstrates the feasibility of EDL modified carbon as Zn2+ storage cathode and great prospect for constructing high performance ZHSCs.
An RNA G‐Quadruplex Structure within the ADAR 5′UTR Interacts with DHX36 Helicase to Regulate Translation
Authors: Lyu Kaixin , Chen Shuo‐Bin , Chow Eugene Yui‐Ching , Zhao Haizhou , Yuan Jia‐Hao , Cai Meng , Shi Jiahai , Chan Ting‐Fung , Tan Jia‐Heng , Kwok Chun Kit 
Published: October 2022

AbstractRNA G‐quadruplex (rG4) structures in the 5′ untranslated region (5′UTR) play crucial roles in fundamental cellular processes. ADAR is an important enzyme that binds to double‐strand RNA and accounts for the conversion of Adenosine to Inosine in RNA editing. However, so far there is no report on the formation and regulatory role of rG4 on ADAR expression. Here, we identify and characterize a thermostable rG4 structure within the 5′UTR of the ADAR1 mRNA and demonstrate its formation and inhibitory role on translation in reporter gene and native gene constructs. We reveal rG4‐specific helicase DHX36 interacts with this rG4 in vitro and in cells under knockdown and knockout conditions by GTFH (G‐quadruplex‐triggered fluorogenic hybridization) probes and modulates translation in an rG4‐dependent manner. Our results further substantiate the rG4 structure‐DHX36 protein interaction in cells and highlight rG4 to be a key player in controlling ADAR1 translation.