bluuebunny/crossref_metadata_2025_split huggingface dataset:
De arriba hacia abajo: reflexiones sobre la regulación de las relaciones entre artesanos y diseñadores en México
Authors: Martínez González Mercedes , Ibarra Rojas Lucero , Pérez Ortiz Luis Alejandro , González Rodríguez Roberto 
Published: September 2022

Aunque en la historia de México ha existido una fuerte tensión en la relación entre artesanos y diseñadores, hasta hace poco tiempo se hicieron visibles casos de explotación que han derivado, entre otras cosas, en la Ley Federal de Protección del Patrimonio Cultural de los Pueblos y Comunidades Indígenas y Afromexicanas. Si bien la legislación y visibilización del problema representan un avance hacia la construcción de relaciones más horizontales, todavíaqueda mucho por reflexionar y por entender sobre las aristas que lo conforman. Así, el objetivo de este artículo es atender a las siguientes preguntas: ¿cuál es el origen de la relación desigual entre artesanos y diseñadores en México?, ¿cómo se describe actualmente? y ¿qué aportaciones puede hacer esta ley al respecto? Para lo anterior, proponemos como metodología de este trabajo un necesario diálogo interdisciplinario entre el diseño, la antropologíay el derecho, enunciado en la exposición de dos casos en los que se muestran aspectos importantes de esta relación: uno en el pasado —descrito a través de investigación bibliográfica— y otro en el presente —al que sumamos testimonios obtenidos mediante trabajo de campo etnográfico—; uno involucra a una población indígena y el otro no; para luego vincularlos al análisis de las legislaciones mencionadas. A partir de este proceso, encontramos que la tensión entre artesanos y diseñadores se da desde que se profesionaliza la práctica del diseño en México. Y esto sucede mientras se intentan consolidar leyes y políticas públicas que buscan regular prácticas, que desde su origen se han planteado desiguales. Concluimos destacando algunas claves centrales para una relación más horizontal entre el sector del diseño y el sector artesanal.
Neutrophil extracellular traps as markers of thromboinflammation in the pathogenesis of female genital tract and breast malignant neoplasms
Authors: Slukhanchuk E. V. , Bitsadze V. O. , Solopova A. G. , Khizroeva J. Kh. , Gris J.-Ch. , Elalamy I. , Makatsariya A. D. 
Published: September 2022

Introduction. Thrombosis is a formidable complication of the oncological process that still profoundly contributes to overall mortality despite the anticoagulant use. According to the recent data, thrombosis in cancer represents a special type of prothrombotic state, wherein thromboinflammationis one of its constituents. In addition, thromboinflammation contributes both to the disease progression and intensity of metastasis processes. Recently, a large number of studies worldwide have been devoted to investigating thromboinflammation in cancer patients.Aim: to assess NETosis activity (the process of neutrophils extracellular traps synthesis), namely, the concentration of citrullinated histone H3 (citH3) as a blood plasma NETosis marker in women with malignant genital organs and breast neoplasms.Materials and Мethods. The prospective observational controlled non-randomized study included 45 patients (main group) with malignant neoplasms of uterus body, ovaries, cervix (adenocarcinoma of the cervical canal) and mammary glands admitted to the hospital for planned surgical treatment (13, 15, 5 and 13 patients, respectively) and 33 women with benign neoplasms of the genital organs and mammary gland (control group). The plasma citН3 concentration was determined using an enzyme immunoassay.Results. It was found that cancer patients had citН3 concentration significantly increased (1.434–2.058 ng/ml) compared with the control group (0.281–0.371 ng/ml). The concentration of citH3 in patients with tumors of the uterine body and cervix ranged from 2.271 to 2.992 ng/ml, patients with ovarian tumors – from 1.357 to 2.123 ng/ml, patients with breast tumors – from 0.331 to 0.859 ng/ml. The study revealed no significant differences in the citH3 concentration in patients with breast tumors compared to the control group. Upon elevating citН3 concentration, such parameters as C-reactive protein, D-dimer, neutrophils and platelets count, as well as neutrophils/lymphocytes ratio were significantly increased. Significant differences were revealed in platelet count in the main group (236,68–273,77×109/L) vs. control group (178,14–202,35×109/L).Conclusion. The study demonstrated the activation of NETosis in patients with tumors of the uterine body as well as cervix (adenocarcinoma) and ovaries that might be combined with hemostasis activation and systemic inflammatory response.
Perspectives for usising mobile apps in higher educational institutions
Authors: Колосова А.Н. , Престер А.Д. , Тинькова Е.В. , Тиньков С.А. 
Published: September 2022

Цифровизация уверенно входит во все сферы общества и экономики. Толчком к усилению значимости электронного образования и электронных средств образования стала пандемия коронавируса. Вопросы эффективности такого образования поднимаются на всех уровнях. В статье рассматривается понятие мобильного обучения, перечислены основные достоинства и недостатки использования мобильных приложений в образовательном процессе, приведены примеры российского и зарубежного опыта мобильного обучения, а также анализ социологического исследования с целью выявления наиболее важных составляющих мобильного приложения для студентов высших учебных заведений.
Digitalization is confidently entering all spheres of society and the economy. The impetus for increasing the importance of e-education and e-education was the coronavirus pandemic. Questions of the effectiveness of such education are being raised at all levels. The article discusses the concept of mobile learning, lists the main advantages and disadvantages of using mobile applications in the educational process, provides examples of Russian and foreign experience of mobile learning, as well as an analysis of a sociological study in order to identify the most important components of a mobile application for university students.
Designing Serverless architecture applications
Authors: Гордина А.Т. , Забродин А.В. , Хомоненко А.Д. 
Published: September 2022

Рассматривается модель бессерверной архитектуры облачных вычислений. Проведено сравнение с традиционной многоуровневой архитектурой. Рассмотрено использование API-шлюза – связующего звена между клиентом и сервисами. Приведен пример спецификации приложения по управлению грузоперевозками. Рассмотрено внедрение бессерверной архитектуры в микросервисную. Определены принципы проектирования основных компонентов модели FaaS – функция как сервис – составляющей бессерверных вычислений. Обосновано создание бессерверной архитектуры и задач, решаемых при разработке приложения. В качестве провайдера облачных услуг выбран Yandex.Cloud.
The latest model of serverless cloud computing architecture is considered. A comparison with the traditional multi-level architecture is made. The use of an AP I gateway, a link between the client and services, is considered. An example specification for a freight management application is provided. The introduction of a serverless architecture into a microservice one is considered. The principles of designing the main components of the FaaS model – a function as a service – a component of serverless computing are determined. The creation of a serverless architecture and the tasks to be solved during the development of the application are substantiated. Yandex. Cloud was chosen as the cloud service provider.
A comparative bioequivalence study to evaluate the pharmacokinetic profile and safety of single-dose of dydrogesterone 10 mg tablets in healthy adult female volunteers
Authors: Sharma Akhilesh D. , Chatterjee Anindita , Vaddem Radhakrsihna 
Published: September 2022

Background: Dydrogesterone is a progesterone derivative. It is indicated in variety of disorders requiring progesterone administration. The basic aim of this bioequivalence (BE) study was to compare the pharmacokinetic profile of generic dydrogesterone 10 mg tablets (test product- Dydrosure) versus the innovator brand.Methods: This was a randomized, open-label, balanced, two-treatment, two-period, two-sequence, two-way crossover, single oral dose BE study conducted in healthy adult females under fasting conditions. A total of 28 subjects participated and 27 subjects completed both the study periods with 14 days washout in between. A total of 23 serial blood samples were collected starting from pre-dose to 72-hour post-dose. The primary pharmacokinetic parameters included peak plasma concentration (Cmax), area under the curve from zero to time t (AUC0-t) and zero to infinity (AUC0-inf); and 90% confidence intervals (CIs) of geometric least square mean (LSM) ratio of test product versus reference product were computed to evaluate the BE. The safety evaluation was based on reported adverse events (AEs) and laboratory parameters.Results: The 90% CIs of geometric LSM ratio of all primary pharmacokinetic parameters were within the range of 80 to 125%. The sequence, period and treatment did not have significant effect on the primary pharmacokinetic parameters. A single AE of dizziness was reported with the test product which was mild in intensity and transient in nature.Conclusions: Based on the statistical analysis of dydrogesterone, it is concluded that the test product (T): Dydrosure (dydrogesterone tablets IP 10 mg) manufactured by Alkem Laboratories Ltd., India is bioequivalent to the innovator’s brand, in terms of rate and extent of absorption under fasting conditions. The test product can be used interchangeably with the innovator’s brand.
Quality of life in drug resistant tuberculosis
Authors: Chatterjee Siddharth 
Published: September 2022

Background: India has largest population of drug resistant tuberculosis, the treatment of which is long and full of adverse drug reactions. Despite the ongoing research in clinical and pharmacological aspects, quality of life in drug-resistant tuberculosis remains less explored. Methodology: This hospital based cross-sectional study done in the at tertiary care center in Surat, from January 2019 to February 2020, enrolling patients above 18 years, with multi-drug/ extensively drug resistant tuberculosis, who suffered > 1 adverse drug reaction after commencing treatment. SF-36 was administered and QOL scores calculated in social, mental and physical domains. Results: Among the 120 patients studied, majority(87.5%) were had pulmonary tuberculosis. 92.5% and 7.2% were multi-drug resistant and extensively drug resistant respectively. The quality of life was poor in all three domains- physical (25.1), social (39.5)and mental (39.5).Gender, type of tuberculosis, past history of tuberculosis did not affect the QOL significantly. Conclusion: Drug-resistant tuberculosis along with its associated adverse drug reactions greatly impacts the quality of life in all domains. Measures need to focus not just on treatment of disease but also the adverse drug reactions, rehabilitation and counselling measures as well. Keywords: Drug-resistant Tuberculosis, Adverse drug reactions, Quality of life
Comparison of sodium fluoride and serum separator tubes for blood glucose estimation – What’s the best option?
Authors: Samuel Joel Kevin Raj , V. G Karpaghavalli , Chandrasekaran Shanmugapriya 
Published: September 2022

The efficacy of sodium fluoride tubes in preserving glucose was compared against a serum separator tube with a gel barrier. We compared the fall in blood glucose levels in a fluoride - oxalate tube against levels in a serum separator tube. A heparinized tube was used as a standard.45 samples were drawn from healthy patient volunteers and distributed into the different tubes. Patients on medications or with chronic kidney disease were excluded. Glucose estimation was done by glucose oxidase-peroxidase method using a semi-automated colorimetric analyser. Samples were immediately centrifuged and stored at room temperature. The fall in glucose levels in each tube was measured at predefined time intervals of 1, 2, 4, 12 and 24 hours.There was no statistically significant difference in the glucose values measured in the fluoride and serum separator tubes at all time intervals from 1 to 24 hours. There was no statistically significant difference in the glucose values measured in all three tubes until 4 hours. However, there was an error beyond acceptable limits (for medical decision making as per CLIA criteria) in the difference in values between the fluoride and heparin tubes at 2 and 4 hours.Thus, there is no difference between use of a fluoride tube or a serum separator tube for up to 24 hours. A serum separator tube can be used when many analytes are to be measured in the same sample and a fluoride tube can be used when only glucose is to be estimated. A heparinized tube will suffice if glucose estimation will be done within one hour of collection.
Comparison of Hematological and Biochemical Parameters and Cardiovascular Risk Scores in Patients Applying to the Obesity Outpatient Clinic
Authors: KAYA Nursel , GAMSIZKAN Zerrin , SUNGUR Mehmet Ali 
Published: September 2022

Objective: The aim of this study was to compare hematological and biochemical parameters and cardiovascular risk scoring in patients admitted to the obesity outpatient clinic.
Method: In this descriptive cross-sectional study, data of the patients who admitted to the Obesity Outpatient Clinic of Duzce University Research and Application Hospital between 2017 and 2018 were evaluated retrospectively. Age, gender, smoking status, presence of Diabetes Mellitus (DM), and body mass index (BMI) were recorded and the cardiovascular risk of the patients was calculated by using the scoring system of the European Society of Cardiology (ESC) and Turkish Society of Cardiology (TSC).
Results: A total of 631 participants were included in the study. The mean age was 38.9±12.1 (min=21, max=65) and 75.1% of the patients were female and 24.9% were male. It was observed that 19.2% of the patients were smokers, 4.6% had DM and 36.9% had insulin resistance. When the patients were evaluated according to the BMI scores, it was found that 3.3% of them were underweight, 7.3% were normal weight, 22.5% were overweight and 66.9% were obese. According to TSC risk scoring system, 51.4% of the patients were in low risk, 20.5% were in medium risk and 28.1% were in high risk category. According to the ESC risk scoring system, 83.5% of the patients were in low risk, 10.9% were in medium risk and 5.5% were in high risk category. According to both risk scoring systems, there were significant differences between the risk groups in terms of age, gender, BMI, and presence of DM (p
Calibrating ECD, Surge, and Swab Models Using Downhole Pressure Measurements to Avoid Wellbore Instability and Allow Safe Tripping
Authors: Ciolkosz Ryan , Gunn Philip , Palacios José 
Published: September 2022

Abstract
Regions of difficult drilling including Alaska's North Slope with easily destabilized shales and formations in the Alberta's Deep Basin with inherently narrow drilling windows offer numerous drilling challenges. Managed Pressure Drilling (MPD) techniques are implemented for a multitude of reasons including reducing pressure cycling, ensuring wellbore stability limits are adhered to, managing swab and surge while tripping, and managing rollover style fluid to fluid displacements.
Effective MPD techniques require accurate surge, swab, and annular friction models as they are critical to drilling operations. A comparison of modelled data to Pressure While Drilling (PWD) measurements indicate that established fluid models alone cannot be relied on for accurate modelling. A series of data comparisons show the limitations of established models to accurately predict wellbore hydraulics. The implications of model limitations on MPD operations specifically are shown and their differences to actual data are quantified.
Mediating effects of self-esteem on the relationship between self-compassion and empathy among Vietnamese university students.
Authors: Tran Minh Anh Quang , Hà Tú Anh , Chau Nguyen Ngoc Thao , Dang Thien An Nguyen , Ngo Vinh Tai 
Published: September 2022

Abstract
Empathy is a critical element of subjective well-being and is an important personality trait for undergraduate students. To improve undergraduate students’ empathy, the current study examines the relationship between self-compassion and empathy and the mediating role of self-esteem underlying this relationship. Participants were six hundred and twenty-two (320 males and 302 females) students from five Vietnamese universities, aged 18-21 years ( M age = 19.5; SD age = 0.95 years), who completed self-compassion scale (SCS), empathy scale in adults (BES-A), and self-esteem scale of Toulouse (ETES).The results indicated that (1) self-compassion was positively associated with empathy; (2) and self-esteem mediated the relationship between the two variables. Therefore, enhancing undergraduate students’ self-compassion may be an efficacious way to improve undergraduate students’ empathy. However, additional study is needed to elucidate the roles of self-compassion in the educational context.
Fstl1 suppresses breast cancer lung metastasis by inhibiting M2-like tumor-associated macrophages recruitment towards the lung
Authors: yang ying , Lu Tao , Jia Xiao-wei , Gao Yan 
Published: September 2022

Abstract
Immune cell infiltration in the tumor microenvironment is associated with cancer prognosis. Tumor-associated macrophages (TAMs) play an essential role in tumor initiation, progression, and metastasis. Follistatin-like protein 1 (Fstl1), a glycoprotein widely expressed in human and mouse tissues, is a tumor suppressor in various cancers and a regulator in macrophage polarization. However, how Fstl1 affects the crosstalk between breast cancer cells and macrophages remains unclear. Analyzing the public data, we found that Fstl1 expression significantly decreases in breast cancer tissues compared with normal breast tissues, and high expression of Fstl1 in patients means prolonged survival. Using flow cytometry, we found that total macrophages and M2-like macrophages increased in the metastatic lung tissues during breast cancer lung metastasis of Fstl1+/- mice. Cellular experiments in vitro showed that Fstl1 inhibited macrophage migration towards 4T1 cells via decreasing colony stimulating factor 1 (CSF-1), transforming growth factor-β1 (TGFB1) and vascular endothelial growth factor-α (VEGF-α) expression of 4T1 cells. We demonstrated that Fstl1 inhibited M2-like tumor-associated macrophages recruitment towards the lung and suppressed TGFB1/Smad2/3 pathway and relevant cytokines expression of 4T1 cells. Thereby we find a potential therapeutic strategy contributing to breast cancer.
Clinical Application of Machine Learning in the Assessment of Pulmonary Embolism in Patients with Gastrointestinal Cancer
Authors: Kim Joo Seong , Kim Kyungdo , Lee Sang Hyub , Lee Seung-Bo , Kim Kwangsoo , Kim Dongmin , Lee Min Woo , Park Namyoung , Choi Jin Ho , Cho In Rae , Paik Woo Hyun , Lee Jun Kyu , Ryu Ji Kon , Kim Yong-Tae 
Published: September 2022

Abstract
Pulmonary thromboembolism (PTE) is one of the most important complications in gastrointestinal cancer patients. However, there were few studies that predict pulmonary embolism using machine learning (ML). The purpose of this study was to develop an ML based prediction model for PTE in gastrointestinal cancer patients, and to compare its performance with the conventional model. In a tertiary hospital, patients who underwent computed tomographic pulmonary angiography (CTPA) were reviewed retrospectively from 2010 to 2020. Demographic and predictor variables including the Wells score and D-dimer were investigated. A total of 446 gastrointestinal cancer patients were analyzed in this study. The overall incidence of PTE was 30.0%. Compared with the conventional model (AUROC 0.605), the performance of ML model predicting PTE was improved (0.706, P = 0.002) and was further improved with additional input of further demographic factors including age and sex (0.743, P < 0.001). The number of patients classified as requiring CTPA was significantly reduced according to the prediction with ML (1.8% vs 9.4%, P < 0.001). Prediction model based on ML might have advantages to improve the diagnostic performance and reduce the number of CTPA compared to the conventional model for PTE in patients with gastrointestinal cancer.
The oncogene EIF3c promotes esophageal squamous cell carcinoma tumorigenesis by inhibiting cell proliferation and inducing cell apoptosis
Authors: lu zhengyang , Sheng Binwu , yang Ganghua , Xu Qinhong 
Published: September 2022

Abstract
Background
It has been reported that EIF3c (Eukaryotic initiation factor 3c) was associated with carcinogenesis of several cancer. However, the role of EIF3c in human esophageal squamous cell carcinoma (ESCC) is still unknown. The aim of present study was to explore the relationship between EIF3c and ESCC, and further investigate the effect of EIF3c in ESCC cells and potential molecular mechanism.
Methods
The MRNA expression data and the clinical information of ESCC patients was obtained from TCGA and used for the analysis of association between EIF3c and ESCC. SiRNA transfection was performed to knock down EIF3c in ESCC cells. Cellomics ArrayScan, colony formation and CCK-8 assay was used to test cell proliferation. Flow cytometry assay was used to test apoptosis and cell cycle. Western blot assay was used to measure protein expression. Microarray assay and Ingenuity Pathway Analysis (IPA) was used to profile gene expression and physiological processes effected by EIF3c in ESCC cells.
Results
Firstly, EIF3c exhibited higher expression in ESCC tissue compared with normal esophageal tissue. Furthermore, silencing EIF3c resulted in cell proliferation inhibition in ESCC cells. In addition, EIF3c knockdown induced cell apoptosis and cell cycle arrest. Moreover, microarray assay and Ingenuity Pathway Analysis (IPA) revealed 1081 differentially expressed genes (DEGS) including 593 upregulated genes and 488 downregulated genes, and the related canonical pathways and possible up-regulators after silencing EIF3c in ESCC cells.
Conclusion
Our study for the first time demonstrated the role of EIF3C as oncogene in ESCC and the underlying molecular mechanism.