bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Effective Protocol for Management of International Arrivals at Risk in COVID-19 Pandemic: Experience From the Pre-Hospital Covid-19 Response Teams at Xi'an, China
Authors: Zou Yifan , Zou Yuliang , Dart Anthony M. , Zhang Yuping , Wang Yousen , Fan Fenling 
Published: March 2022

BackgroundThe coronavirus disease 2019 (COVID-19) outbreak within China has been well controlled and stabilized since early April 2020. Therefore, the current major focus in China is to prevent the introduction of COVID into China from international arrivals. To achieve this, pre-Hospital COVID-19 Response Teams (pHCRTs) have been established.ContextThe pHRCTs were established in Xi'an, China in early 2020. During the 12 months covered in this report, there were 356 international flight arrivals with over 5,000 COVID-19 Nucleic Acid Test (NAT) positive people, 500 of them with symptomatic COVID-19 and requiring admission to special hospitals. All other arrivals were managed in dedicated facilities by pHRCTs. The outcome measure of this report was the number of positive cases among the pHRCT members.DetailsFour hundred forty-two staff worked in the pHCRTs during the reporting period. Despite multiple throat swab PCR tests during their pHRCTs tour of duty, and the subsequent mandatory 14-day quarantine required before return to the general community, no staff became NAT positive.ConclusionThe prevention of community transmission from imported cases is a vital part of the strategy to maintain the low numbers of cases in countries which have achieved control, or suppression of local internal cases. The program of pHCRTs described in this article gives successful protocols for transportation of patients who are infectious based on the minimal transmission of virus and staff safety. The strategies employed may prove useful in future pandemics.
Clinical and Laboratory Outcomes in HIV-1 and HTLV-1/2 Coinfection: A Systematic Review
Authors: Montaño-Castellón Iris , Marconi Cleyde Sheyla Chachaqui , Saffe Clara , Brites Carlos 
Published: March 2022

AimTo perform a systematic review to describe the available findings on clinical outcomes in HIV-1 and HTLV-1/HTLV-2 co-infected individuals since 1995.DesignThis Systematic Review used PECO criteria follow by PRISMA reporting guidelines and registered as CRD42021279062 (Prospero database). The Newcastle-Ottawa Scale assessed the methodological quality of included studies.Data Collection and AnalysisA systematical search in PubMed/MEDLINE, Embase, Web of Sciences databases for cross-sectional, case-control, or cohort studies design to identify clinical and laboratorial outcomes related to HIV-1 and HTLV-1/2 coinfection. Search strategy: [(“HIV-1” AND “HTLV-1” OR “HTLV-2”) AND (“Coinfection”) AND (1990/01/01:2021/12/31[Date- Publication])].ResultsA total of 15 articles were included on this systematic review describing data of 2,566 mono and coinfected patients, 58% male, with mean age was 35.7 ± 5.7 years. HIV-1 and HTLV-1 coinfected patients were more likely to had shorter survival and faster progression to death or mortality than monoinfected ones. Coinfected had higher CD4 cell counts and less likelihood of ART use. In addition, higher frequency of diseases like ichthyosis (22.2 vs. 6.8%), scabies (18.6 vs. 0%), candidiasis (42 vs. 12%), Strongyloidiasis (15.4 vs. 2%) and neurological manifestations like encephalopathy, peripheral neuropathy and HAM/TSP were more frequently reported in coinfected patients.ConclusionsHIV-1 and HTLV-1 coinfection and HIV-1 and HTLV-1 /2 triple coinfection were related to shorter survival, higher mortality rate, and faster progression to death, while coinfection by HIV-1/HTLV-2 seems to have neutral association with longer survival, slower AIDS progression, and lower mortality rate. The available evidence indicates an urgent need for prevention and control measures, including screening, diagnosis, and treatment of HIV-1 and HTLV-1/2 coinfected patients. Test-and-treat strategy for patients living with HIV in areas endemic for HTLV infection is mandatory, to avoid the risks of delayed therapy and death for coinfected patients.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42021279062.
The Evaluation of the Relationship Between Oral Habits Prevalence and COVID-19 Pandemic in Adults and Adolescents: A Systematic Review
Authors: Mirhashemi Amirhossein , Khami Mohammad Reza , Kharazifard Mohammdjavad , Bahrami Rashin 
Published: March 2022

Background and ObjectiveThe aim of this study was to systematically review the relationship between oral habits (bruxism- temporomandibular disorders) and COVID-19 pandemic in adults and adolescents.Method and MaterialA comprehensive search of the literature through PubMed, Scopus, Embase, google scholar and Cochrane databases was conducted. Such keywords as COVID-19, SARS-CoV-2, bruxism, adult, and adolescent were used.ResultsIn the initial search 818 articles were obtained; 68 cases were duplicates and excluded. By reviewing the article title, 714 articles were removed because they were not relevant to the topic. The remaining articles were reviewed, and studies that did not meet the inclusion criteria, as well as letter to editors and expert opinions were excluded. Finally, 11 articles were allowed to enter the study. Out of 11 related articles, 5 studies were excluded from the present study due to mismatch of the target population; and finally 6 articles were thoroughly reviewed.ConclusionStudies have shown that stress caused by the COVID-19 pandemic increases detrimental oral habits such as bruxism as well as temporomandibular disorders in adults and adolescents; In general, young single women are at high risk and more exposed to these harmful oral habits.
Rectal Signet Ring Cell Carcinoma: Post-Chemoradiotherapy Evaluation by MRI and Corresponding to Pathology
Authors: Zhou Yin , Li Qingshu , Mao Yun 
Published: March 2022

BackgroundSignet ring cell carcinoma (SRCC) is recognized as an uncommon subtype of colorectal carcinoma (CRC). It showed characteristic magnetic resonance imaging (MRI) manifestations. However, the MRI features post-chemoradiotherapy (CRT) were not reported, and it is unknown whether the current tumor regression grade (TRG) system by MRI (mrTRG) is applicable to SRCC.PurposeTo summarize the image features of rectal SRCC on post-CRT images corresponding to the pathology, and to determine the predicting value of mrTRG compared with TRG by pathology (pTRG).MethodsWe retrospectively enrolled seven patients (male: female = 3:4; mean age, 45.1 years) with biopsy-pathology proved SRCC, who underwent pre- and post-CRT MR imaging followed by surgery. An experienced gastrointestinal radiologist accessed mrTRG using a 5-point grading system by mandard standard on T2 weighted image (T2WI) and then added diffusion weighted image (DWI) in a 1-month interval. Additionally, MRI features were recorded on pre- and post-CRT images as follows: pattern (target sign) and main signal intensity of T2WI, characterized manifestation of DWI, and mean Apparent Diffusion Coefficient (ADC)values. The mrTRG and all MR image features were compared to the post-operative pathology.ResultsAt post-CRT histology, five patients got a good response (TRG 1, n = 4; TRG 2, n = 1), one patient got a partial response, and one patient got a poor response. The accuracy of MRI predicted the pathology response by mandard standard was 14% and increased to 71.4% when added DWI. After CRT, different degrees of homogeneous high SI without enhancement representing acellular mucin were observed in all patients, and the thick-ring high SI turned into a thin-target sign in most good responders. Moreover, the tumor volume decreased or slightly increased in good responders, while it markedly increased in the partial and poor responder by 57% and 73.8%, respectively.ConclusionHomogeneous high SI on T2WI and thin target sigh on DWI were the main MRI changes of RSRCC, which was corresponding to the mucinous regression and represents for good response post-CRT. The mrTRG and tumor volume was not a reliable indicator to the pathology response. We considered that DWI should be added to T2WI to evaluate RSRCC response to CRT.
Development of a Loop-Mediated Isothermal Amplification Assay Coupled With a Lateral Flow Dipstick Test for Detection of Myosin Binding Protein C3 A31P Mutation in Maine Coon Cats
Authors: Sukumolanan Pratch , Demeekul Kanokwan , Petchdee Soontaree 
Published: March 2022

BackgroundMyosin-binding protein C3 A31P (MYBPC3-A31P) missense mutation is a genetic deviation associated with the development of hypertrophic cardiomyopathy (HCM) in Maine Coon cats. The standard detection of the MYBPC3-A31P mutation is complicated, time-consuming, and expensive. Currently, there has been a focus on the speed and reliability of diagnostic tools. Therefore, this study aimed to develop a loop-mediated isothermal amplification assay (LAMP) coupled with a lateral flow dipstick (LFD) test to detect MYBPC3-A31P mutations in Maine Coon cats.Materials and MethodsFifty-five Maine Coon cats were enrolled in this study, and blood samples were collected. MYBPC3-A31P was genotyped by DNA sequencing. Primers for LAMP with a LFD test were designed. The optimal conditions were determined, including temperature and time to completion for the reaction. The sensitivity of A31P-LAMP detection was compared between agarose gel electrophoresis (the standard method) and the LFD test. The A31P-LAMP-LFD test was randomly performed on seven cats (four with the A31P mutation and three wild-type cats).ResultsThe A31P-LAMP procedure was able to distinguish between cats with MYBPC3-A31P wild-type cats and MYBPC3-A31P mutant cats. The LAMP reactions were able to be completed in 60 min at a single temperature of 64◦C. Moreover, this study demonstrated that A31P-LAMP coupled with the LFD test allowed for A31P genotype detection at a lower DNA concentration than agarose gel electrophoresis.DiscussionsThis new A31P-LAMP with a LFD test is a successful and reliable assay with a rapid method, cost-effectiveness, and low requirements for sophisticated equipment for the detection of MYBPC3-A31P mutations. Thus, this assay has excellent potential and can be recognized as a novel screening test for hypertrophic cardiomyopathy associated with MYBPC3-A31P mutations in felines.
Use of Citrated Whole Blood for Point-of-Care Viscoelastic Coagulation Testing in Dogs
Authors: York Whitney , Smith M. Ryan , Liu Chin-Chi 
Published: March 2022

BackgroundA new, portable bedside coagulation monitor (VCM Vet) has provided a user-friendly, cartridge-based method to perform viscoelastic testing. However, the use of native whole blood limits the time to analyze the sample to minutes. The objective of this study is to assess whether citrated whole blood can be utilized with the cartridge-based system and whether the results are comparable to those of native whole blood. A secondary objective is to assess the viability of citrated whole blood results after up to 4 hours of resting.MethodsThe study population consisted of 10 healthy mixed breed dogs. Whole blood samples were collected via jugular venipuncture. Blood was immediately transferred to the VCM test cartridge for native whole blood control group analysis per the manufacturer's instructions, and the remainder was used to fill two 3.2% sodium citrate vacutainer tubes. Test group analysis was performed on samples from each tube concurrently after a rest period of 30 min (baseline), 2 h, and 4 h. Citrated whole blood samples were recalcified for analysis immediately prior to introduction into the test cartridge. Data was recorded for all reported parameters. Results from the citrate groups were compared to the control group and to the citrated baseline to assess for differences. Overall results were compared using mixed ANOVA models. Where found, specific differences were evaluated using Tukey's test. Within-sample variation was investigated and reported as median (range). A p &lt; 0.05 was considered significant.ResultsSamples were obtained for a total of 10 control runs and 20 citrated whole blood runs. Comparison of controls to the citrated test groups revealed significant differences in CT (p &lt; 0.001) and MCF (p &lt; 0.002). There were no significant differences between test groups compared to citrated baselines for any parameter. Selected median coefficients of variation were 6.8% (0–68.8%) for CT, 2.4% (0–19.46%) for alpha angle, 3.2% (0–27.4%) for MCF, and 0% (0–16.3%) for 45-min LY45.ConclusionCitrated whole blood samples can be used with the VCM Vet device; however, new reference intervals for use with citrated whole blood will be required. Results using citrated whole blood samples are not significantly different from baseline after up to 4 h of resting.
Effects of Same-Sex Marriage Legalization for Sexual Minority Men in Taiwan: Findings From a Prospective Study
Authors: Huang Yu-Te , Liang Zurong 
Published: March 2022

Objective: On May 24, 2019, same-sex marriage (SSM) was legalized in Taiwan. Increasing research in western countries has yielded longitudinal evidence about the psychosocial benefits of SSM for sexual minority individuals, but they have rarely included sexual minority-specific measures or considered participants’ relationship status. This study aimed to examine the short-term effects associated with the legalization of SSM for gay and bisexual men in Taiwan.Methods: A panel sample of 731 gay and 132 bisexual men participated in baseline (May 2019) and follow-up (October 2020) online surveys to report their depressive symptoms, distal sexual minority stress, internalized homophobia, and outness status.Results: The results demonstrated significant reductions in depressive symptoms and distal sexual minority stress along with increased rates of coming out to friends, family, and parents. These changes were similar for partnered and un-partnered individuals. Fixed-effect regression analysis indicated that the decline in distal sexual minority stress and internalized homophobia contributed to the decline in depressive symptoms.Conclusion: This study preliminarily supports the positive effects of SSM in promoting sexual minority men’s mental health and disclosure in Taiwan.
Automation of Property Acquisition of Single Track Depositions Manufactured through Direct Energy Deposition
Authors: Gil Jorge , de Jesus Abílio , Silva Maria Beatriz , Vaz Maria F. , Reis Ana , Tavares João Manuel R. S. 
Published: March 2022

Metallic additive manufacturing processes have been significantly developed since their inception with modern systems capable of manufacturing components for structural applications. However, successful processing through these methods requires extensive experimentation before optimised parameters can be found. In laser-based processes, such as direct energy deposition, it is common for single track beads to be deposited and subjected to analysis, yielding information on how the input parameters influence characteristics such as the output’s adhesion to the substrate. These characteristics are often determined using specialised software, from images obtained by cross-section cutting the line beads. The proposed approach was based on a Python algorithm, using the scikit-image library and optical microscopy imaging from produced 18Ni300 Maraging steel on H13 tool steel, and it computes the relevant properties of DED-produced line beads, such as the track height, width, penetration, wettability angles, cross-section areas above and below the substrate and dilution proportion. 18Ni300 Maraging steel depositions were optimised with a laser power of 1550 W, feeding rate of 12 gmin−1, scanning speed of 12 mm s−1, shielding gas flow rate of 25 Lmin−1 and carrier gas flow rate of 4 Lmin−1 for a laser spot diameter of 2.1mm. Out of the cross-sectioned beads, their respective height, width and penetration were calculated with 2.71%, 4.01% and 9.35% errors; the dilution proportion was computed with 14.15% error, the area above the substrate with 5.27% error and the area below the substrate with 17.93% error. The average computational time for the processing of one image was 12.7s. The developed approach was purely segmentational and could potentially benefit from machine-learning implementations.
Satisfacción laboral del docente universitario desde la cultura organizacional
Authors: Díaz Tinoco Angélica , Valderrama Rios Olga Giovanna , Merino Lozano Alicia Lourdes , Nuñez Zarazú Llerme , Cuba Sancho Juana Matilde 
Published: March 2022

El propósito de estudio es identificar la relación de la cultura organizacional en la satisfacción laboral de los docentes de una universidad de la costa peruana. Investigación descriptiva, correlacional y transversal. La muestra fue de 48 docentes, obtenidos mediante muestreo aleatorio simple. Los instrumentos utilizados fueron dos; la escala de satisfacción laboral SL-SPC y otro para cultura organizacional, ambos en escala de Likert. Para los análisis estadísticos se usó la correlación de Spearman. Como resultado se obtuvo que el 66.7% presentó una cultura organizacional neutra, el 20.8% fuerte y el 12.5% débil. El 79.2% indicaron tener una satisfacción laboral media, 14.6% alta y solo el 6.3% baja. La cultura organizacional se relacionó con la satisfacción laboral de los docentes (r=0,375, p= 0,009). Se concluye Existe una correlación entre la cultura organizacional la satisfacción laboral, actividades en la primera mejoraran la segunda.
Implicancia de la lingüística textual en la comprensión lectora y nivel de logro, Perú
Authors: More López Jesús Manuel , Méndez Espinoza María Angélica , Yovera Saldarriaga José , Jamanca Ramirez Marco Antonio , Cruz Nieto Dante Daniel 
Published: March 2022

Para mejorar la comprensión lectora es importante aplicar una buena lingüística textual. El objetivo del estudio radica en demostrar la importancia del uso en comprensión lectora en nivel logros. La metodología empleada fue bajo la investigación explicativa de diseño cuasi experimental, se utilizaron instrumentos escala de Likert y cuestionario. La población fue nivel secundario del I.E. Nº 20503 “José Carlos Mariátegui”. Los resultados demostraron rechazar la hipótesis nula y aceptar hipótesis alterna al confirmarse que existen diferencias significativas después de la aplicación en las variables, con un nivel de confianza del 95%; siendo la asintótica (bilateral) 0,000; la prueba de normalidad muestra que en ambos grupos las variables no se distribuyen según una ley normal; ya que la significancia asintótica (bilateral) de ambos grupos es 0,013; es decir para la comprensión lectora está por debajo del nivel de significación alfa prefijado (0,05). Se concluye que, es interactiva, dinámica, interdisciplinaria en la comprensión y producción de textos.
Securing InfiniBand Networks with the Bluefield-2 Data Processing Unit
Authors: Diamond` Noah , Graham Scott , Clark Gilbert 
Published: March 2022

Interest in securing InfiniBand networks with encryption is growing. However, the performance benefit realized by InfiniBand’s use of Direct Memory Access (DMA) to bypass the kernel and avoid intervention from host Central Processing Units (CPUs) is at odds with IP datagram encryption techniques. Encryption forces data through the CPU before transmission and decryption, incurring multiple clock cycles. The Bluefield-2 Data Processing Unit (DPU) is Nvidia-Mellanox’s latest system on chip that combines a high-performance, programmable processor, network interface card (NIC), and flexible hardware accelerators. This research characterizes the Bluefield-2’s capability to accelerate IPsec encryption in hardware. Results show that the Bluefield-2’s hardware accelerators are capable of supporting a secure IPsec tunnel with a throughput of nearly 16 Gb/s. Offloading IPsec encryption operations to the hardware accelerators on the Bluefield-2 is a promising method for adding confidentiality, integrity, and authentication to InfiniBand networks.
Addressing the Skills Shortage in Cybersecurity
Authors: Davies Gareth , Mison Angela , Eden Peter 
Published: March 2022

Security by design is an up and coming paradigm which seeks to decrease the opportunity for corruption and disruption, and to increase the inherent stability, dependability and resilience of systems. Cyber experts need to be involved in the design phase as Finagle's Law, interpreted for cybersecurity, is 'if it can be hacked, it will – at the worst possible time'. Testing is designed to counter Murphy's Law and reduce resistentialism. Defensive programming, original cybersecurity, carries an overhead, for which there is often no demonstrable return. The priority of the design stage cybersecurity expert is to plan for contingencies and think like a hacker. It is about risk management; understanding this dictates security by design requirements in the knowledge that interconnected systems' security is only as strong as its weakest link. Definition and audit of Service Level Agreements (SLA) are an essential part of cybersecurity, as is the audit of any third party suppliers of componentry of the system under design. Governance and policy definitions, exciting for some, are integral to cybersecurity. Beyond this, the cybersecurity expert must consider system failure. Recent ransomware attacks have demonstrated the necessity for business continuity plans as recovery has still taken time. The Blue Team Field Manual has an impressive list of necessary documentation and actions required in this event, but glosses over the effort required. While the above is rolling maintenance, threat hunting differs. Every vulnerability or threat must be evaluated for consequential impact. Either a passionate interest in psychology or an extremely jaundiced view of the world is a necessary attribute for cybersecurity. Reality is so different from the aspirations of potential pen testers, incident responders, and AI security engineers facing 3 – 5 post-graduation years to proficiency, it is no wonder disillusion results in a shortage of 3.5 million cybersecurity experts.
In vitro antioxidant potential and antimicrobial activity of some Cameroonian plant extracts
Authors: Bayoï James Ronald , Râpeanu Gabriela , Stănciuc Nicoleta , Cotărleţ Mihaela , Constantin Oana Emilia , Etoa Francois-Xavier 
Published: March 2022

A study on Cameroonian edible and medicinal plants was undertaken to assess their potential as food preservatives and natural food colorants. The ultrasound-assisted technique was used for the extraction of bioactive compounds. A total of 16 extracts prepared from 7 plants (Aframomum melegueta S., Ageratum conyzoides L., Cympobogon citratus Stapf, Garcinia kola Heckel, Lantana camara L., Nauclea diderrichii, Vernonia amygdalina) were assayed to detect phytochemicals and assess antioxidant potential using the scavenging DPPH radical method and antimicrobial activity (10 mg/mL) against ten microorganisms by the agar well diffusion method. The ethanolic extract from L. camara leaves revealed the highest polyphenols and flavonoids contents. In contrast, the hexane/acetone extract from A. conyzoides and L. camara leaves had the highest chlorophyll a (Chl a) and chlorophyll b (Chl b) contents, whereas the highest carotenoid content was found in L. camara leaves. The ethanol extracts exhibited more significant antioxidant activity than hexane/acetone extracts. All seven plants (100%) inhibited the growth of at least one tested foodborne and spoilage bacteria and fungi. The germination of both Bacillus spp. spores were also affected. The hexane/acetone extracts were by far the best antimicrobial agent, and extract from L. camara leaves was one of the most effective, with a large antimicrobial spectrum. The antimicrobial activity of extracts was correlated to the amount of carotenoids and chlorophylls. HPLC-DAD revealed bioactive compounds as chlorogenic and caffeic acids found as major phenols in ethanolic extract of L. camara leaves, whereas lutein, carotene, and zeaxanthin were the specific carotenoids present in hexane/acetone extract of the same plant.