bluuebunny/crossref_metadata_2025_split huggingface dataset:
A mindfulness-based stress management program for caregivers of allogeneic hematopoietic stem cell transplant (HCT) patients: Protocol for a randomized controlled trial
Authors: Yang Min-Jeong , Yepez Valerie V. , Brandon Karen O. , Reblin Maija , Pidala Joseph , Jim Heather S. L. , Meyer Jerrold S. , Gore L. Robert , Khera Nandita , Lau Penny , Sauls Rachel M. , Jones Sarah R. , Vinci Christine 
Published: April 2022

Objectives
Caregivers of allogeneic hematopoietic stem cell transplant (HCT) cancer patients experience high caregiver burden and carry a significant amount of responsibility. Mindfulness has the potential to lessen caregiver burden by aiding in stress management. To date, no studies have examined the efficacy of mindfulness in reducing caregiver burden in this population. Based on our pilot study demonstrating initial feasibility and acceptability of FOCUS (Focusing On mindfulness for Caregivers Under Stress), this 3-arm randomized controlled trial aims to examine the efficacy of a 6-week mindfulness-based stress management program for allogeneic HCT caregivers. Hypotheses include that the FOCUS condition will have lower post-treatment caregiver burden and that patients of these caregivers will have better patient health outcomes compared to other treatment conditions.

Method
Eligible caregivers will be randomly assigned to one of three treatment conditions: FOCUS, Healthy Living (HL; active control), and Enhanced Care (EC; usual care). Caregivers in FOCUS and HL will participate in 6-week weekly individual treatment sessions and will be sent brief daily momentary interventions/messages. Caregivers in all conditions will complete daily diaries over the course of treatment. Patients of enrolled caregivers will be enrolled for assessments only. Participants will complete assessments at baseline, end of treatment, 2- and 6-months post-treatment. Biomarker data will be collected via hair cortisol concentrations from caregivers at baseline and 6 months post-treatment.

Results
Recruitment is ongoing.

Conclusions
The data collected from this study will provide evidence on the efficacy of mindfulness in alleviating HCT caregiver stress and impacting patient health outcomes.

Trial registration
The current study is registered in clinicaltrials.gov (NCT05078229); see https://clinicaltrials.gov/ct2/show/NCT05078229?term=christine+vinci&draw=2&rank=1.
Character strengths of women with polycystic ovary syndrome in a single center
Authors: Ghazeeri Ghina , Ibrahim Nour , Khalifeh Fatin , Beyrouthy Christine , El-Taha Lina , Bizri Maya 
Published: April 2022

Purpose
To investigate the difference in character strengths (CSs) between patients with and without polycystic ovary syndrome (PCOS) and the association between biological (i.e., testosterone levels) and psychological factors (i.e., character strengths).

Patients and methods
A total of 99 women divided into PCOS (49) and non-PCOS (50) groups who presented to the gynecological clinics at the women’s center in the American University of Beirut Medical Center in 2017 were included. Women were assessed for testosterone bioavailable levels and completed a questionnaire that included Hospital Anxiety and Depression Scale and Values in Action Survey-72. Univariate and multivariable analyses were performed to examine the association of CSs between the two groups and its predictors.

Results
The scores of hope, judgement, perspective, and transcendence of the PCOS group were significantly higher in comparison with healthy participants. An increase in free androgen index was negatively correlated to the score of judgement only.

Conclusion
Women with PCOS have their own profile of character strengths and virtues that constitute judgement, hope, perspective, and transcendence. This in turn can be utilized to reinforce those personality strengths and thus decrease the psychological distress and mood disorders accompanied with this disease.
Adalimumab vs Infliximab in Pediatric Patients With Crohn's Disease: A Propensity Score Analysis and Predictors of Treatment Escalation
Authors: Bronsky Jiri , Copova Ivana , Kazeka Denis , Lerchova Tereza , Mitrova Katarina , Pospisilova Kristyna , Sulovcova Miroslava , Zarubova Kristyna , Hradsky Ondrej 
Published: April 2022

INTRODUCTION:
Two antitumor necrosis factor therapies (infliximab [IFX] and adalimumab [ADA]) have been approved for the treatment of pediatric Crohn's disease (CD) but have not been compared in head-to-head trials. The aim of this study was to compare the efficacy and safety of ADA and IFX by propensity score matching in a prospective cohort of pediatric patients with luminal CD and at least a 24-month follow-up.

METHODS:
Among 100 patients, 75 met the inclusion criteria, and 62 were matched by propensity score. We evaluated time to treatment escalation as the primary outcome and primary nonresponse, predictors of treatment escalation and relapse, serious adverse events, pharmacokinetics, and effect of concomitant immunomodulators as secondary outcomes.

RESULTS:
There was no difference between ADA and IFX in time to treatment escalation (HR = 0.63 [95% CI 0.31–1.28] P = 0.20), primary nonresponse (P = 0.95), or serious adverse events. The median (interquartile range) trough levels at the primary outcome were 14.05 (10.88–15.40) and 6.15 (2.08–6.58) µg/mL in the ADA and IFX groups, respectively. On a multivariate analysis, the combination of anti-Saccharomyces cerevisiae antibody negativity and antineutrophil cytoplasmic antibody positivity was a strong independent predictor of treatment escalation (HR 5.19, [95% CI 2.41–11.18], P < 0.0001). The simple endoscopic score for CD, L3 disease phenotype, and use of concomitant immunomodulators for at least the first 6 months revealed a trend toward significance on a univariate analysis.

DISCUSSION:
Propensity score matching did not reveal substantial differences in efficacy or safety between ADA and IFX. The anti-S. cerevisiae antibody negativity and antineutrophil cytoplasmic antibody positivity combination is a strong predictor of treatment escalation.
Safety and Antiviral Activity of EGFR Inhibition by Erlotinib in Chronic Hepatitis C Patients: A Phase Ib Randomized Controlled Trial
Authors: Saviano Antonio , Habersetzer François , Lupberger Joachim , Simo-Noumbissie Pauline , Schuster Catherine , Doffoël Michel , Schmidt-Mutter Catherine , Baumert Thomas F. 
Published: April 2022

INTRODUCTION:
Significant hepatocellular carcinoma (HCC) risk persists after chronic hepatitis C (CHC) cure. Preclinical studies have shown that erlotinib, an oral epidermal growth factor receptor (EGFR) inhibitor, has an antiviral activity and HCC chemopreventive effect. Erlotinib is metabolized in the liver, and its safety in patients with CHC is unknown. This study aimed to assess the safety and antiviral activity of erlotinib in patients with CHC.

METHODS:
In this investigator-initiated dose-escalation phase Ib prospective randomized double-blind placebo-controlled study, noncirrhotic hepatitis C virus (HCV) patients received placebo or erlotinib (50 or 100 mg/d) for 14 days with a placebo-erlotinib ratio of 1:3. Primary end points were safety and viral load reduction at the end of treatment (EOT). The secondary end point was viral load reduction 14 days after EOT.

RESULTS:
This study analyzed data of 3 patients receiving placebo, 3 patients receiving erlotinib 50 mg/d, and 3 patients receiving erlotinib 100 mg/d. One grade 3 adverse event was reported in the placebo group (liver enzymes elevation), leading to treatment discontinuation and patient replacement, and 1 in the erlotinib 100 mg/d group (pericarditis), which was not considered to be treatment-related. Grade 2 skin rash was observed in 1 erlotinib 100 mg/d patient. No significant HCV-RNA level reduction was noted during treatment, but 2 of the 3 patients in the erlotinib 100 mg/d group showed a decrease of >0.5 log HCV-RNA 14 days after EOT.

DISCUSSION:
Erlotinib demonstrated to be safe in noncirrhotic CHC patients. An antiviral activity at 100 mg/d confirms a functional role of EGFR as an HCV host factor in patients. These results provide perspectives to further study erlotinib as an HCC chemopreventive agent in patients with CHC.
Impact of fish stock enhancement on fish yield of floodplain wetlands in different agro-climatic zones of Assam, India
Authors: Yadav Anil Kumar , Das Kishore Kumar , Borah Simanku , Das Pronob , Bhattacharjya Birendra Kumar , Das Basanta Kumar 
Published: April 2022

Abstract
Floodplain wetlands located in Ganga-Brahmaputra basin are some of the major inland fisheries resources of India with substantial resource size of 554,213 ha. These resources are amenable to capture fisheries and fisheries enhancement. The Guwahati Regional Centre of Indian Council of Agricultural Research-Central Institute of Fisheries Research Institute, Barrackpore, West Bengal, India has developed protocols for scientific fish stock enhancement (through supplementary stocking) for floodplain wetlands (beels) of Assam. These enhancements aim to increase fish yield based on extensive field studies in the beels of the state during 2007–12. In order to assess the impact of fish stock enhancement following the Institute's guidelines, data on fish production of 183 beels under the administrative control of Assam Fisheries Development Corporation Ltd., Guwahati, India were collected and analysed for the period from 2007–08 to 2016–17. The data were analysed for two periods of 5 years each (2007–08 to 2011–12: period-I and 2012–13 to 2016–17: period-II) for unstocked beels (that are not subjected to supplementary stocking, thereby representing capture fisheries) and stocked beels (where supplementary stocking with Indian major and minor carps for fish stock enhancement is practised) in reference to different agro-climatic zones of Assam. The average fish yield from unstocked beels (96 no.) was 156.6kg ha-1yr-1 during period-I, which increased to 206.4kg ha-1yr-1 during period-II, showing an increase of 31.8% over the five-year period. As much as 47.5% of the beels (87 no.) of the state are now subjected to supplementary stocking for fish stock enhancement. The average fish yield rate of stocked beels was 258.5kg ha-1yr-1 during period-I, which increased to 455.2kg ha-1yr-1 during period-II. Thus, average fish yield rates increased as much as 76.1% over the five year periods in stocked beels showing that supplementary stocking resulted in significant enhancement of fish production from the beels of Assam after the Institute's intervention.
Status of biodiversity and limno-chemistry of Deepor Beel, a Ramsar site of international importance: Conservation needs and the way forward
Authors: Bhattacharjya B.K. , Saud B.J. , Borah S. , Saikia P.K. , Das B.K. 
Published: April 2022

Abstract
Deepor Beel is a prominent floodplain wetland and a Ramsar site of northeastern (NE) India (Ramsar site no. 1207) covering a 40.14 km2 area and connected to River Brahmaputra. It provides numerous economic (e.g., livelihood and nutritional security) and ecological benefits (e.g. moderation of floods, groundwater recharge, repository of biodiversity) to the locality and its people. Deepor Beel was declared a Wildlife Sanctuary in 1989 and the area covered by the perennial water spread (10.1 km2) was subsequently designated as a Bird Sanctuary by the Government of Assam in 2009. The present paper provides an overview of the rich floral and faunal diversity of the wetland, including aquatic macrophytes (58 species), diatoms (65), zooplankton (171), bryozoans (5), molluscs (15), aquatic insects (55), prawns (3), crabs (2), finfish (68), amphibians (11), reptiles (33), birds (234) and mammals (24), in addition to the beel's limno-chemistry as well its conservation threats and suggested strategies. The wetland supports 18 globally threatened vertebrate species. Eleven bird species occurring in the wetland (Aythya baeri, A. nyroca, Leptoptilos dubius, L. javanicus, Ephippiorhynchus asiaticus, Gyps bengalensis, G. tenuirostris, Haliaeetus leucogaster, Pelecanus philippensis, Sarcogyps calvus, Threskiornis melanocephalus) have been included in the IUCN Red List of Threatened Species. Finfishes reported from the wetland declined from 67 species in 1999 to 64 between 2016 and 2018, which is a matter of concern. According to available information on limno-chemistry, the waters of the wetland have remained within the favorable range of water quality for fish production. Major threats faced by the wetland (e.g. pollution, encroachment, natural processes, etc.) and possible conservation strategies (e.g. control of aquatic pollution, prevention/ control of siltation, enacting and enforcing appropriate legislation, and other strategies) are outlined.
The effects of hydrology on macroinvertebrate traits in river channel and wetland habitats
Authors: Growns Ivor , Tsoi Iris Wing , Southwell Mark , Mika Sarah , Lewis Sam , Vincent Ben 
Published: April 2022

AbstractIncreased need for freshwater for human uses from the mid-1900s has severely impacted rivers and floodplain wetlands so that they are some of the most seriously degraded environments in the world. Research and monitoring in this area to date has focused on understanding ‘flow-ecology’ relationships, without investigating the mechanisms underlying them. The use of species traits offers a tool for defining mechanistic connections between biotic responses and environmental conditions. We examined nine macroinvertebrate trait categories in both wetlands and channels to determine whether their profiles responded to hydrology in the Gwydir River system in the northern Murray-Darling Basin, Australia. Trait responses were shown for the wetlands but not the river channels. Twelve traits showed positive relationships with the time the wetlands were connected to their river channels. It is unclear the reason(s) why the river channel invertebrate traits did not respond to hydrology. However, the use of environmental flows in the river systems may be important to other aspects of macroinvertebrate assemblages such as their role in food webs to support higher-order consumers.
Nástroj zjišťující epistemická přesvědčení učitelů v kontextu výuky historie
Authors: Říčan Jaroslav , Pešout Ondřej , Zábranský Vilém 
Published: April 2022

Předkládaná výzkumná studie je zaměřena na měření epistemických přesvědčení praktikujících učitelů a studentů učitelství v kontextu výuky historie.
Cílem šetření bylo přezkoumat faktorovou strukturu přeloženého nástroje Beliefs about History Questionnaire (BHQ) adaptovaného na české prostředí. Nástroj vychází z rámců historického myšlení podpořených kognitivními výzkumy zasazenými do sociálně konstruktivistického přístupu a výzkumů explicitně usouvztažňujících problematiku epistemických přesvědčení (vývojové modely) ve vyučování dějepisu, historie a vlastivědy.
Z výsledků vyplývá, že teoreticky navržené dimenze dotazníku BHQ tvoří psychometricky samostatné faktory. Nástroj dobře rozlišuje dimenze subjektivistického a kriteriálního přístupu k povaze historických znalostí. Naopak dimenze napodobujícího přístupu nedisponuje přesvědčivými psychometrickými vlastnostmi.
Zjištěné závěry je třeba interpretovat vzhledem k vybrané populaci. Výsledky jsou diskutovány ve vztahu se zahraničními výzkumy jak v doménově obecném kontextu výzkumů epistemických přesvědčení, tak i v doménově specifickém. Na základě uvedených výsledků jsou navrženy potenciální možnosti optimalizace nástroje, především položková úprava napodobujícího přístupu, a potenciální možnosti dalších výzkumných směřování. Modifikovaný nástroj disponuje potenciálem k uplatnění jak v pregraduální přípravě studentů učitelství historie (včetně dějepisu a vlastivědy), tak i učitelů z praxe. Na základě předložených výsledků empirického šetření a kontextu výzkumů zahraniční provenience autoři této studie diskutují význam epistemických přesvědčení napříč vzdělávacími stupni.
Policy challenges and food security in Alqadarif State, Sudan
Authors: Bushara Mohamed O. A. , Mohamed Hassan H. I. 
Published: April 2022

Food security is under focused issue in Sudan as a whole and AlQadarif State is not apart from that. According to the integrated food security phases classification (IPC) report April (2015), about 60% of the population suffering from food insecurity in the State. This problem needs to be solved by clear and sound policies and strategies. The main objective of this study is to investigate and evaluate the Food Security and Nutrition (FSN) policies and strategies in the State. To achieve this objective secondary data such as annual reports, policy documents were collected from all key line institutions and primary data were collected by the mean of a questionnaire the main results of this research are that: there were no clear food security and nutrition policy documents for the key line institutions in the State. Also, there was a gap between the policymakers at the State level and the locality level. 42% of the policymakers at the locality level did not aware of the existence of the FSN body in the State. About 94% of the policymakers in the localities believed that the Chamber of Zakat plays a very important role in helping at FSN situations. About 92% of policymakers in the state said that finance is not sufficient. The majority of the localities policymakers, 94%, do not have any (FSN) database in their localities. Finally, the main recommendation of this study is to build a food security and nutrition policy/strategy putting the conservation of the natural resources in consideration.
Editorial Volume 13, Issue 2
Authors: Rodrigues Paulo Cesar Chagas 
Published: April 2022

This issue of the Independent Journal of Management & production (IJM&P) features a selection of articles submitted and revised until September 2021. Observe the works are the fruit of research and publications of undergraduate, postgraduate and entrepreneurs.
It is important to mention that all the works are showed without any kind of payment. All of them are published free from payments or taxes.
The publication also counts on the work of researchers from various parts of the world, which have undergone a process of peer review.
Challenge of Establishing Materials Testing Standards with Miniature Specimen for Solders
Authors: Hiyoshi Noritake , Itoh Takamoto , Yamamoto Takaei , Kanayama Hideyuki 
Published: April 2022

Abstract
Solder is an essential material for connecting parts inside electrical devices. Although there is an international standard for the chemical composition of solder, there is no testing standard for evaluating the mechanical properties and characteristics of solder as a structural material. The Committee on High Temperature Strength of Materials, the Society of Materials Science, Japan, proposed some testing standards for solders in the early 2000s based on the results from research activities of the Solder Strength Evaluation Method Working Group. The primary objective of the standardization at that time was to acquire stable testing data and to eliminate institutional differences. The recommended specimen diameter is 10 mm. To verify the size difference between the 10-mm-diameter specimen and an actual solder joint inside an electrical device, the working group has been investigating materials testing techniques using a specimen with a reduced diameter of 3 mm. The research results were published in 2020 as Standard for Miniature Testing of Solders. We have also conducted a series of systematic experiments based on the testing standards for Sn-3.0Ag-0.5Cu. The results obtained so far are as follows: In the tensile tests, the tensile strength of the 10-mm- and 3-mm-diameter specimens are almost identical, independent of the specimen size, although the casting method and heat treatment conditions are different. The effect of specimen size on the creep rupture life is insignificant. In the low-cycle fatigue tests, stable fatigue data can be obtained even at high temperatures using the 3-mm-diameter specimen.
Unique features of transcription termination and initiation at closely spaced tandem human genes
Authors: Nissani Noa , Ulitsky Igor 
Published: April 2022

AbstractThe synthesis of RNA polymerase II (Pol2) products, which include messenger RNAs or long noncoding RNAs, culminates in transcription termination. How the transcriptional termination of a gene impacts the activity of promoters found immediately downstream of it, and which can be subject to potential transcriptional interference, remains largely unknown. We examined in an unbiased manner the features of the intergenic regions between pairs of ‘tandem genes’—closely spaced (< 2 kb) human genes found on the same strand. Intergenic regions separating tandem genes are enriched with guanines and are characterized by binding of several proteins, including AGO1 and AGO2 of the RNA interference pathway. Additionally, we found that Pol2 is particularly enriched in this region, and it is lost upon perturbations affecting splicing or transcriptional elongation. Perturbations of genes involved in Pol2 pausing and R loop biology preferentially affect expression of downstream genes in tandem gene pairs. Overall, we find that features associated with Pol2 pausing and accumulation rather than those associated with avoidance of transcriptional interference are the predominant driving force shaping short tandem intergenic regions.
LAYOUT STRATEGY OF PROTEASE PRODUCTION FROM INDUSTRIAL FISHERY WASTES IN KUANTAN, PAHANG
Authors: Mustafa Shariman , Abdullah Nurul Ain 
Published: April 2022

Layout strategy is considered as key decision that controls long-term effectiveness of production operational activities. Fish wastes in the fisheries sector can have negative impact on the environment if not handled properly. This issue plays a huge role in the commitment for choosing the right layout suitable for production of protease from those wastes. The whole analysis of this research was conducted in Kuantan, Pahang that has concentrated many fisheries processing industries which generated quite huge tons of waste material. The purpose of this study was to define a layout strategy that was sufficient for production of protease from fishery waste. Data was obtained from interview sessions with manager of Kilang Keropok Pak Lah followed by documents review and observations of production activities for layout analysis. The study had determined the protease product process flow and therefore developed layout suited to the protease production processed from identified fishery wastes at the site. Feasibility analysis performed had determined the proposed protease production would benefit consumers, increases manufacturing capacity as well as open up new market and business opportunity for company. The study concluded that protease production from fisheries waste increases career opportunities, generate new income and bringing positive impact to the local community. From the research findings gathered, authors strongly recommended further study in this sector looking for other types of commercial products for new economic viability.
SERVICES SECTOR IN SARAWAK: CHALLENGES AND WAY FORWARD
Authors: Lee Wen Chiat , Voon Boo Ho 
Published: April 2022

Service sector is an important sector in Sarawak and it contributes about 36 percent to Sarawak’s Gross Domestic Product (GDP) in 2020. The sector also contributes 56 percent of total employment of the state. However, there are some challenges in service sector. Among the key challenges are low productivity growth, shortage of skilled workforce and weak internet connectivity in rural area that restricted the development of service sector. This paper presents the performance of service sector in Sarawak and the challenges of the service sector. The proposed recommendations to face the challenges include, providing training to semi-skilled and low-skilled workers to improve the productivity, providing quality and cheap food to attract tourists, and developing internet infrastructure in rural Sarawak.