bluuebunny/crossref_metadata_2025_split huggingface dataset:
Totally Organic Hydrogel‐Based Self‐Closing Cuff Electrode for Vagus Nerve Stimulation
Authors: Terutsuki Daigo , Yoroizuka Hayato , Osawa Shin‐ichiro , Ogihara Yuka , Abe Hiroya , Nakagawa Atsuhiro , Iwasaki Masaki , Nishizawa Matsuhiko 
Published: September 2022

AbstractAn intrinsically soft organic electrode consisting of poly(3,4‐ethylenedioxythiophene)‐modified polyurethane (PEDOT‐PU) is embedded into a bilayer film of polyvinyl alcohol (PVA) hydrogels for developing a self‐closing cuff electrode for neuromodulation. The curled form of the PVA hydrogel is prepared by releasing internal stress in the bilayer structure. The inner diameter of the cuff electrode is set to less than 2 mm for immobilization to the vagus nerve (VN) of humans and pigs. The stability of the immobilization is examined, while the pressure applied to a nerve bundle is at a harmless level (≈200 Pa). Since the electrode is totally organic, MRI measurements can be conducted without image artifacts. The large electric capacitance of the PEDOT‐PU (≈27 mF cm−2) ensures a safe stimulation of living tissues without Faradaic reactions. The practical performance of the cuff electrode for VN stimulation is demonstrated by observation of bradycardia induction in a pig.
Dextran and Its Derivatives: Biopolymer Additives for the Modulation of Vaterite CaCO3 Crystal Morphology and Adhesion to Cells
Authors: Campbell Jack , Ferreira Ana M. , Bowker Laura , Hunt John , Volodkin Dmitry , Vikulina Anna 
Published: September 2022

AbstractNowadays, a great demand for the development of novel drug delivery systems with high potential for bench‐to‐market transition attracts scientific attention toward materials that are already approved for biomedical use. Here, controlled fabrication of hybrid organic inorganic mesoporous crystals is realized in physiologically relevant conditions by co‐synthesis of vaterite CaCO3 in the presence of dextran (DEX) or its functional derivatives. The effects of DEX molecular weight and chemical structure on morphology, porosity, and stability of the hybrids are investigated. Molecular weight of DEX does not affect the crystal growth but leads to the partial blocking of crystal pores. Co‐synthesis of DEX functionalized with either carboxymethyl (CM) or diethylaminoethyl (DEAE) groups drastically increased crystal porosity without influencing crystal size. pH‐dependent vaterite‐to‐calcite recrystallization is significantly suppressed by inclusion of carboxymethyl‐dextran (CM‐DEX), making vaterite crystals stable in acidic medium, whereas the incorporation of diethylaminoethyl‐dextran (DEAE‐DEX) has no effect. The hybrids prepared with charged DEX derivatives possess stronger adhesion to normal human dermal fibroblasts: three times higher crystal adherence compared to pristine crystals. These results provide fundamental physical–chemical insights into the crystallization of DEX/vaterite hybrids and are discussed in view of the potential of these functional delivery carriers for biomedical and other applications.
Excellent Adhesive Performance for the Thermal Insulation Attribute to Micromorphology Regulation and Controllable Injection of Oxygen‐Containing Groups by Low Temperature Plasma Treatment
Authors: Yu Haomiao , Qin Yang , Wang Deqi , Xu Dongming , Di Yang , Jia Hongbing , Li Fengsheng , Liu Jie 
Published: September 2022

AbstractA low temperature plasma (LTP) surface treatment technology operated under atmospheric conditions with air as the treatment atmosphere is developed for micromorphology regulation and controllable injection of oxygen‐containing groups on the surface of ethylene propylene diene methylene (EPDM) thermal insulation to achieve excellent adhesion performance. Optical emission spectroscopy is used to analyze the active species in the LTP. The key treatment parameters are optimized by contact angle measurements, resulting in thermal insulation sample with 3.32 times higher surface energy than the original sample. The surface morphology and composition of the samples are characterized. It is demonstrated that the surface of the thermal insulation shows new structures, thus increasing the surface area of the thermal insulation. In addition, a large number of oxygen‐containing groups are introduced to the surface of the thermal insulation, especially OH, and the O/C increases by 78.57%. Finally, the peel test is performed on the insulation samples with comparison to the grinding samples, which shows that the peel strength of the treated samples increases by 126.92%, while an additional 22% is also obtained compared to the grinding samples. This excellent adhesive performance is mainly caused by the synergistic effect of chemical crosslinking, hydrogen bonding, and mechanical interlocking.
Potassium Methacrylate Additive Strategy for Improved Stability of Ultrathin Copper‐Based Perovskite Solar Cells
Authors: Lin Huang , Miao Renjie , Fu Sheng , Wang Haiqiao , Lai Huahang , Wang Weiyan , Song Weijie 
Published: September 2022

AbstractPerovskite solar cell (PSC) using ultrathin metal transparent electrode is a promising power source for wearable electronics and aerospace applications. However, the environmental stability of device is challenging, due to the undesirable interdiffusion of metal and halogen ions. In this work, PSCs are constructed by using ultrathin copper (Cu) electrodes with low reactivity, combined with potassium methacrylate (KMMA) additive. On one hand, carbonyl groups in KMMA interact with the perovskite and improve quality of perovskite films. As a result, the power conversion efficiency (PCE) of ultrathin Cu‐based PSC is increased from 12.49% to 14.72%. On the other hand, benefitting from the binding of K+ with halogen ion, the interdiffusion of Cu and I ions is hindered. Thus, PSCs retain 80% and 75% of the initial PCE under heating at 85 °C for 130 h and maximum power point for 300 h, respectively. To the best of the knowledge, it is one of the best thermal and operational stability for the PSCs using metal‐based electrodes. At last, the symmetric PSCs exhibit superior folding stability which maintain 85.3% of initial PCE after folding for 500 cycles. Foldable PSCs on ultrathin Cu electrodes with excellent stability are attractive power sources in wearable applications.
Temperature‐Tunable Terahertz Perfect Absorber Based on All‐Dielectric Strontium Titanate (STO) Resonator Structure
Authors: Zhao Jingcheng , Cheng Yongzhi 
Published: September 2022

AbstractA temperature‐tunable terahertz (THz) perfect absorber (PA) composed of a periodic array of deep subwavelength micro‐cross‐shaped (MCS) structures of the strontium titanate (STO) resonator is proposed and investigated theoretically, which can be applicable for the temperature sensing. Simulation results indicate that the absorbance of 99.8% at 0.221 THz can be achieved when the designed PA is under the room temperature of T = 300 K, which is in good agreement with the calculation done by the coupling mode theory (CMT). The simulated distributions of electric and magnetic fields in the unit‐cell structure of the designed PA reveal that the observed perfect absorption is mainly attributed to the Mie resonance of the all‐dielectric MCS structure STO. In addition, this designed PA is polarization‐insensitive and wide‐angle absorption for both transverse magnetic (TM) and transverse electric (TE) waves. The resonance absorption properties of the designed PA can be controlled by changing the geometrical parameters of STO resonator structure. The designed PA can be served as a temperature sensor, which has a sensitivity of about 0.37 GHz K−1 since the electrical property of the STO is dependent on the variation of surrounding temperature. Furthermore, the perfect absorption can also be achieved by the PAs using the square, circular, and ring STO structures. The proposed design concepts of the STO‐based tunable PAs can find potential THz applications in sensing, detecting, imaging, and so on.
Intraparticle Double‐Scattering‐Decoded Sonogenetics for Augmenting Immune Checkpoint Blockade and CAR‐T Therapy
Authors: Wang Duo , Zhang Mengqi , Zhang Yan , Qiu Guanhua , Chen Jie , Zhu Xiaoqi , Kong Cunqing , Lu Xiuxin , Liang Xiayi , Duan Lixia , Fang Chao , Liu Junjie , Zhang Kun , Luo Tao 
Published: September 2022

AbstractGenetically arming new chimeric antigen receptors (CARs) on T cells is a prevalent method to fulfill CAR‐T immunotherapy. However, this approach fails to completely address the poor infiltration, complex immunosuppressive tumor microenvironment (ITM), and insufficient immune cells, which are recognized as the three dominant hurdles to discouraging the trafficking and persistence of CAR‐T and immune checkpoint blockade (ICB) immunotherapies against solid tumors. To address the three hurdles, a sonoimmunity‐engineered nanoplatform is designed in which a rattle‐type‐structured carrier enables intraparticle‐double‐scattering to generate massive reactive oxygen species (ROS) during the sonodynamic process. Abundant ROS accumulation can directly kill tumor cells, release antigens, and activate systematic immune responses for expanding effector T or CAR‐T cells, while alleviating ITM via immunosuppressive macrophage polarization and reduction in pro‐tumorigenic cytokine secretion. Furthermore, the co‐loaded phosphodiesterase‐5 inhibitors release nitric oxide (NO) to impel vascular normalization and open the infiltration barrier (IB) for allowing more T cells to enter into the tumor. Systematic experiments demonstrate the feasibility of such intraparticle‐double‐scattering‐decoded sonogenetics in the sonoimmunity‐engineered nanoplatforms for expanding effector T or CAR‐T cells, thereby promoting their infiltration into tumors and alleviating ITM. These compelling actions lead to excellent CAR‐T and ICB immunotherapies against solid tumors with repressed tumor metastasis.
Romiplostim use in pregnant women with immune thrombocytopenia
Authors: Bussel James B. , Cooper Nichola , Lawrence Tatiana , Michel Marc , Vander Haar Emilie , Wang Kejia , Wang Hongmei , Saad Hossam 
Published: September 2022

AbstractTreatment for immune thrombocytopenia (ITP) in pregnancy is hampered by the lack of fetal safety evidence of maternally‐administered medications. The Pregnancy Surveillance Program (PSP) collected patient information from 2017–2020 for pregnancy, birth outcomes, and adverse events (AEs) for 186 women exposed to romiplostim from 20 days before pregnancy to the end of pregnancy. Timing of exposure was available in 128 women. Seventy‐one mothers (38%) had prepregnancy exposure to romiplostim; intrapartum exposure was known for the first (for many mothers when they discovered their pregnancy), second, and third trimesters for 74 (40%), 22 (12%), and 44 (24%) mothers, respectively, with 15 mothers exposed during >1 trimester. Among the 86 mothers with known pregnancy outcomes, 46 (53%) had at least one pregnancy‐related serious AE (SAE); approximately 2/3 of SAEs were due to underlying ITP. Of 92 mothers with known birth outcomes, 60 (65%) had a normal pregnancy and 16 (17%) had complications, with both categories including term and preterm births; there were 12 (14%) spontaneous miscarriages/stillbirths, 3 (3%) ectopic pregnancies, and 1 (1%) molar pregnancy. Most abnormal births resulted from abnormal pregnancies. There were five neonatal/postnatal AEs of note: inguinal hernia, cytomegalovirus infection, trisomy 8 (third trimester single‐dose romiplostim exposure), single umbilical artery without known anomalies, and development of autism at age 2 years. Seven of 12 infants with neonatal thrombocytopenia had resolution of thrombocytopenia before discharge; all 12 were discharged. Review of pregnancies in women exposed to romiplostim did not reveal any specific safety concerns for mothers, fetuses, or infants.
Review of genetic testing in kidney disease patients: Diagnostic yield of single nucleotide variants and copy number variations evaluated across and within kidney phenotype groups
Authors: Claus Laura R. , Snoek Rozemarijn , Knoers Nine V. A. M. , van Eerde Albertien M. 
Published: September 2022

AbstractGenetic kidney disease comprises a diverse group of disorders. These can roughly be divided in the phenotype groups congenital anomalies of the kidney and urinary tract, ciliopathies, glomerulopathies, stone disorders, tubulointerstitial kidney disease, and tubulopathies. Many etiologies can lead to chronic kidney disease that can progress to end‐stage kidney disease. Despite each individual disease being rare, together these genetic disorders account for a large proportion of kidney disease cases. With the introduction of massively parallel sequencing, genetic testing has become more accessible, but a comprehensive analysis of the diagnostic yield is lacking. This review gives an overview of the diagnostic yield of genetic testing across and within the full range of kidney disease phenotypes through a systematic literature search that resulted in 115 included articles. Patient, test, and cohort characteristics that can influence the diagnostic yield are highlighted. Detection of copy number variations and their contribution to the diagnostic yield is described for all phenotype groups. Also, the impact of a genetic diagnosis for a patient and family members, which can be diagnostic, therapeutic, and prognostic, is shown through the included articles. This review will allow clinicians to estimate an a priori probability of finding a genetic cause for the kidney disease in their patients.
Surface modification of poly(propylene) fabric with graphene oxide‐based silver nanoparticles for antibacterial applications
Authors: Dat Nguyen Minh , Huong Le Minh , Tinh Ninh Thi , Linh Nguyen Thi Thuy , Hai Nguyen Duy , Viet Nguyen Duc , Thinh Doan Ba , Cong Che Quang , Dat Nguyen Tien , Phong Mai Thanh , Hieu Nguyen Huu 
Published: September 2022

AbstractHerein, poly(propylene) (PP) was hydrophilized with oxidating agents and solvents, followed by dip‐coating with silver nanoparticles anchored GO sheets (Ag@GO) prepared by the in‐situ method as reported in our previous study to obtain silver@graphene oxide‐coated poly(propylene) (Ag@GO/PP). The impact of the modifying agents, dipping times, and coating concentrations on the antibacterial activities were studied accordingly via the inhibition zone method. The fabrics were re‐hydrophobized with the reduction of Ag@GO and the functionalization with stearic acid (SA) to form silver@reduced graphene oxide‐coated poly(propylene) (Ag@rGO/PP) and silver@graphene oxide/SA‐coated poly(propylene) (Ag@rGO‐SA/PP), respectively. Characterization of pretreated and modified PP samples was carried out by various modern analysis methods. Simultaneously, the cytotoxicity of the active layers, the release of Ag+ ions, and durability after washing were also investigated. The obtained results representing PP fabrics pretreated with HNO3/isopropanol and dipped in Ag@GO concentration of 2 g/L four times prove a sufficient approach for improving hydrophilization and bio‐compatibility for the PP samples. The fabrics greatly show an impressive interaction with precursors, mostly high antibacterial activity even after four washing cycles via appropriate releasing of Ag+ to ensure the safety in usage. They further suggest that the prepared fabrics could be utilized for actual application as a face mask.
Towards circular economy: A guiding framework for circular supply chain implementation
Authors: Amir Saman , Salehi Niloufar , Roci Malvina , Sweet Susanne , Rashid Amir 
Published: September 2022

AbstractClosing the loop for resource efficiency is a well‐known practice in the industry. To concretize the circular economy implementation strategies, closed‐loop thinking requires innovation and adaptation. Circular supply chains (CSCs) are one of the key enablers in closing the loop by design or intention for value recovery and profit maximization. CSC is an emerging area, and the view of CSC where forward and reverse supply chain is seamlessly integrated with the overall aim to achieve system‐wide circularity is missing in the academic debate. By offering a cross‐functional perspective of CSC, this paper presents a CSC guiding framework to structure and understand the underlying complexities and highlight the crucial elements of the CSC implementation. Thus, this framework lays the basis for CSC within the systemic implementation of CE by closing the loop by design or intention. The framework categorizes the CSC into four building blocks, namely, systemic approach, main drivers, levels of decision making, and mechanisms to manage the full loop closure and minimize the inherent uncertainties of a complex system. The building blocks of the framework are synthesized from various streams of supply chain literature and recurring concepts in the circular economy literature. The CSC framework applicability is illustrated using two industrial cases that are transitioning towards the circular economy.
Inclusion of patients with chronic kidney disease in randomized phase 3 clinical trials in patients with prostate, breast, lung, and colorectal cancer
Authors: Delaye Matthieu , Rousseau Adrien , Try Mélanie , Massard Christophe , Campedel Luca , Hilmi Marc , Bagnis Corinne 
Published: September 2022

AbstractThe objective of this study was to determine the proportion of phase 3 clinical trials investigating a systemic therapy for patients with prostate, breast, lung, or colorectal cancer that excluded patients with Chronic Kidney Disease (CKD) and the exclusion criteria chosen, if any. A search was conducted using the ClinicalTrials.gov database to identify eligible studies. Of the 268 included trials, 185 (69%) had at least one renal exclusion criteria. Of these 185 trials, 116 (63%) had an undefined exclusion criterion. Only disease site was associated with exclusion of patients with CKD in the univariate analysis, but no factors in the multivariate analysis. There are several potential barriers to including patients with CKD in clinical trials. Nevertheless, solutions can be proposed to allow the inclusion of these patients. This would allow them to access to innovative therapeutic strategies, but also allow a better applicability of trial results to this patient population.
Real‐world data on lenalidomide dosing and outcomes in patients newly diagnosed with multiple myeloma: Results from the Canadian Myeloma Research Group Database
Authors: Mian Hira , LeBlanc Richard , Louzada Martha , Masih‐Khan Esther , McCurdy Arleigh , Venner Christopher P. , Stakiw Julie , Kardjadj Moustafa , Jimenez‐Zepeda Victor H. , Sebag Michael , White Darrell , Aslam Muhammad , Song Kevin , Reiman Anthony , Kotb Rami , Gul Engin , Reece Donna 
Published: September 2022

AbstractUsing the Canadian Myeloma Research Group Database, a retrospective study of 167 newly diagnosed, transplant‐ineligible patients with multiple myeloma (MM) that received lenalidomide‐dexamethasone as front‐line treatment was conducted to understand the impact of lenalidomide dosing. Starting dose modifications were common, 42% of patients started on lenalidomide <25 mg with normal renal function. During treatment course, 35% of patients required further dose reduction. Dose reductions in the first year did not have an impact on progression free survival or overall survival. Further studies need to be conducted to understand the impact of dosing strategies of anti‐MM agents in the real world.
Simulation Model for Digital Twins of Pneumatic Vacuum Ejectors
Authors: Stegmaier Valentin , Schaaf Walter , Jazdi Nasser , Weyrich Michael 
Published: September 2022

AbstractIncreasing productivity, as well as flexibility, is required for the industrial production sector. To meet these challenges, concepts in the field of “Industry 4.0” are arising, such as the concept of Digital Twins. Vacuum handling systems are a widespread technology for material handling in industry and face the same challenges and opportunities. In this field, a key issue is the lack of Digital Twins containing behavior models for vacuum handling systems and their components in different applications and use cases. A novel concept for modeling and simulating the fluidic behavior of pneumatic vacuum ejectors as key components of vacuum handling systems is proposed. In order to increase the simulation accuracy, the concept can access instance‐specific data of the used asset instead of object‐specific data. The model and the data are part of the Digital Twins of pneumatic vacuum ejectors, which shall be able to be combined with other components to represent a Digital Twin of entire vacuum handling systems. The proposed model is validated in an experimental test setup and in an industrial application delivering sufficiently accurate results.
Water Loss Predictive Tests in Flooded Lead‐Acid Batteries
Authors: Parnigotto Mattia , Mazzucato Marco , Fabris Daniele , Dainese Lorenzo , Cazzanti Silvia , Bortolamei Nicola , Durante Christian 
Published: September 2022

AbstractDifferent aging processes rates of flooded lead–acid batteries (FLAB) depend strongly on the operational condition, yet the difficult to predict presence of certain additives or contaminants could prompt or anticipate the aging. Linear sweep current (LSC) and gas test (GT) characterizations were reported here to fasten the water consumption evaluation. The two methods were proposed to evaluate the water consumption effect at 60 °C, on a custom cell with a (1+ 2−) plate configuration. The predictive ability of the proposed tests was verified on 9 batches of plates for FLAB preliminary tested with the European standard CEI EN 50342‐1 : 2019‐11 method. LSC and GT tests showed the capability to identify plate batches with anomalous behaviour for the water consumption and good agreement with the European standard CEI EN 50342‐1 : 2019‐11 method. Furthermore, it was found that Tafel parameters determined from LSC and GT tests correlated well with the concentration of Te.
Distribution of potassium during chemical activation of petroleum coke: Electron microscopy evidence and links to phase behaviour
Authors: Montes Vicente , Xiao Ye , Wu Jingfeng , Hill Josephine M. 
Published: September 2022

AbstractIn this study, direct evidence for chemical penetration into petroleum coke particles during activation is presented. In addition, the porosity development was directly related to the sulphur loss and phase behaviour of the species present. Petroleum coke (petcoke, 6 wt.% sulphur) was activated with KOH and NaOH at temperatures between 400 and 800°C. The CS bonds were broken before 400°C in the presence of KOH and before 500°C in the presence of NaOH. Electron microscopy analysis of cross‐sectioned and ultramicrotomed samples revealed that sulphur was still present within the particles and that the hydroxide activation agents had penetrated to the centre of the particles (90–150 μm). After heating to 800°C and washing with a weak acid aqueous solution, essentially all the sulphur was removed, as was any remaining chemical agent. The characterization results, phase diagrams, and complementary experiments with carbonate chemical agents or steam suggest that, during heating, a molten phase formed around the petcoke particles. The composition of this molten phase changed as activation proceeded and both sulphur and ash components were liberated from the petcoke. This better understanding of the activation process will improve the efficiency of preparing activated carbon.