bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nomograms for Predicting Disease-Free Survival in Patients With Siewert Type II/III Adenocarcinoma of the Esophagogastric Junction Receiving Neoadjuvant Therapy and Radical Surgery
Authors: Guo Zhenjiang , Guo Honghai , Tian Yuan , Zhang Ze , Zhao Qun 
Published: June 2022

ObjectiveThis study aimed to develop prognostic prediction models for patients with Siewert type II/III adenocarcinoma of the esophagogastric junction (AEG) who received neoadjuvant therapy (neoadjuvant chemoradiotherapy or neoadjuvant chemotherapy) and radical surgery. A baseline nomogram and a post-operative nomogram were constructed before neoadjuvant therapy and after surgery. The predictive performance of the constructed nomograms was internally validated and compared to the TNM staging system.Materials and MethodsA total of 245 patients diagnosed with Siewert type II/III AEG and treated with neoadjuvant therapy followed by radical surgery at The Fourth Hospital of Hebei Medical University between January 2011 and December 2017 were enrolled. The variables before neoadjuvant therapy were defined as baseline factors, while the variables of baseline factors along with the variables of treatment and postoperative pathology were defined as post-operative factors. To construct the corresponding nomograms, independent predictors of baseline and post-operative factors were identified. The C-index and a time-dependent receiver operating characteristic curve were used to evaluate the model’s discrimination ability. The calibration ability of the model was determined by comparing the probability of predicted free-recurrence to the actual free-recurrence. Decision curve analysis (DCA) was used to determine the clinical usefulness of the nomogram.ResultsAmong the baseline factors, age, cT stage, cN stage, Borrmann type, and staging laparoscopy were independent prognostic predictors. In contrast, among the post-operative factors, age, cN stage, staging laparoscopy, ypT stage, clinical response, number of positive lymph nodes, number of negative lymph nodes, laurén classification, and lymphatic, or perineural invasion (VELPI) were independent prognostic predictors. The two nomograms were constructed using the independent predictors of prognosis. The C-indexes for the baseline and post-operative nomograms were 0.690 (95% CI, 0.644-0.736) and 0.817 (95% CI, 0.782-0.853), respectively. The AUCs of the baseline nomogram at 3 and 5 years were both greater than cTNM (73.1 vs 58.8, 76.1 vs 55.7). Similarly, the AUCs of the post-operative nomogram were both greater than ypTNM (85.2 vs 69.1, 88.2 vs 71.3) at 3 and 5 years. The calibration curves indicated that both models had a high degree of calibration ability. By comparing the DCA at 3 and 5 years, we determined that the two nomograms constructed had better clinical utility than the TNM staging system.ConclusionsThe constructed nomograms have a more accurate predictive ability than the eighth edition TNM staging system, which can be useful for treatment selection and follow-up monitoring of patients.
JBP485, A Dual Inhibitor of Organic Anion Transporters (OATs) and Renal Dehydropeptidase-I (DHP-I), Protects Against Imipenem-Induced Nephrotoxicity
Authors: Wang Chong , Wang Changyuan , Wu Jingjing , Meng Qiang , Jin Huan , Sun Huijun , Kaku Taiichi , Chen Jing , Huo Xiaokui , Liu Kexin 
Published: June 2022

Imipenem (IMP) possesses a broad spectrum of antibacterial activity; however, nephrotoxicity limits its clinical application in patients with renal insufficiency. In our previous studies, a dipeptide, JBP485, a dipeptide with the chemical structure cyclo-trans-4-L-hydroxyprolyl-L-serine, was found to attenuate drug-induced kidney injury. The current study aimed to explore whether JBP485 could relieve IMP-induced kidney injury and clarify the potential molecular pharmacokinetic mechanism. The effects of JBP485 on IMP nephrotoxicity were evaluated in rabbits and human kidney 2 (HK-2) cells. Drug-drug interactions (DDIs) mediated by organic anion transporters (OATs) and dehydropeptidase-I (DHP-I) were explored through pharmacokinetic studies in rats, metabolism assays in the kidney, and uptake studies in OAT-over-expressing cells. The results revealed that JBP485 significantly ameliorated IMP-induced nephrotoxicity in rabbits. Further, incubation of HK-2 cells with JBP485 or cilastatin markedly improved the cell survival rate, inhibited apoptosis and attenuated mitochondrial damage by improving the stability of IMP and reducing its intracellular accumulation. This suggests that DHP-I and OATs might be involved in the protective effect of JBP485. Furthermore, coadministration with JBP485 significantly increased the IMP’s plasma concentration as well as the area under the plasma concentration-time curve (AUC), while decreasing IMP renal clearance and cumulative urinary excretion. Moreover, JBP485 reduced IMP uptake in kidney slices and OAT1/3-human embryonic kidney 293 (HEK293) cells. At the same time, the metabolism of IMP by DHP-I was inhibited by JBP485 with an IC50 value of 12.15 ± 1.22 μM. Finally, the molecular docking assay revealed a direct interaction between JBP485 and OAT1/3 or DHP-I. In conclusion, JBP485 protected against IMP nephrotoxicity in rabbits and HK-2 cells by improving IMP stability and reducing its intracellular accumulation via simultaneous inhibition of renal OATs and DHP-I. JBP485 is a promising renoprotective agent and could serve as an effective supplement to reduce IMP-induced adverse renal reactions in the clinical setting.
HIF1α-Dependent Induction of TFRC by a Combination of Intestinal Inflammation and Systemic Iron Deficiency in Inflammatory Bowel Disease
Authors: Fagundes Raphael R. , Bourgonje Arno R. , Hu Shixian , Barbieri Ruggero , Jansen Bernadien H. , Sinnema Nienke , Blokzijl Tjasso , Taylor Cormac T. , Weersma Rinse K. , Faber Klaas Nico , Dijkstra Gerard 
Published: June 2022

Background and Aims: Iron deficiency (ID) is a frequent extra-intestinal manifestation in patients with Inflammatory Bowel Disease (IBD), who often do not respond to iron supplementation. Iron is a cofactor for hydroxylases that suppress the hypoxia-inducible factor-1α (HIF1α), a transcription factor regulating iron homeostasis. We hypothesized that iron deficiency affects mucosal HIF1α activity in IBD.Methods: IBD patients (n = 101) were subdivided based on iron status (ferritin levels or transferrin saturation) and systemic inflammation (C-reactive protein levels). 154 corresponding ileal and colonic biopsies were analyzed for differential expression of 20 HIF1α pathway-associated genes and related to iron and inflammation status. In vitro expression of selected HIF1α pathway genes were analyzed in wild-type and HIF1A-null Caco-2 cells.Results: Gene expression of the mucosal HIF1α pathway was most affected by intestinal location and inflammatory status. Especially, ileal mucosal TFRC expression, encoding the transferrin receptor TFR1, was increased in inflamed tissue (p &lt; 0.001), and further enhanced in ID. Accordingly, TFRC expression in inflamed tissue associated negatively with serum iron levels, which was not observed in the non-inflamed mucosa. The HIF1α pathway agonist DMOG increased TFRC expression in Caco-2 cells, which was blunted in HIF1A-null cells.Conclusion: We demonstrate that inflammation and anatomical location primarily determine HIF1α pathway activation and downstream TFRC expression in the intestinal mucosa. IBD patients with ID may benefit from treatment with HIF1α-agonists by 1) increasing TFRC-mediated iron absorption in non-inflamed tissue and 2) decreasing mucosal inflammation, thereby improving their responsiveness to oral iron supplementation.
Changes in Acute Myocardial Infarction, Stroke, and Heart Failure Hospitalizations During COVID-19 Pandemic in Tuscany—An Interrupted Time Series Study
Authors: Wang Sophie Y. , Seghieri Chiara , Vainieri Milena , Groene Oliver 
Published: June 2022

Objectives: We evaluate the impact of the COVID-19 pandemic on unplanned hospitalization rates for patients without COVID-19, including their length of stay, and in-hospital mortality, overall, and for acute myocardial infarction (AMI), stroke, and heart failure in the Tuscany region of Italy.Methods: We carried out a population-based controlled interrupted time series study using segmented linear regression with an autoregressive error term based on admissions data from all public hospitals in Tuscany. The primary outcome measure was weekly hospitalization rates; secondary outcomes included length of stay, and in-hospital mortality.Results: The implementation of the pandemic-related mitigation measures and fear of infection was associated with large decreases in inpatient hospitalization rates overall (−182 [−234, −130]), unplanned hospitalization (−39 [−51, −26]), and for AMI (−1.32 [−1.98, −0.66]), stroke (−1.51 [−2.56, −0.44]), and heart failure (−8.7 [−11.1, −6.3]). Average length of stay and percent in-hospital mortality for select acute medical conditions did not change significantly.Conclusion: In Tuscany, Italy, the COVID-19 pandemic was associated with large reductions in hospitalization rates overall, as well as for heart failure, and the time sensitive conditions of AMI and stroke during the months January to July 2020.
ВІДОБРАЖЕННЯ ПОБУТУ ДИТИНИ ШКІЛЬНОГО ВІКУ У ВІТЧИЗНЯНИХ НАУКОВИХ І ЛІТЕРАТУРНИХ ДЖЕРЕЛАХ
Authors: Сухомлинська Ольга Василівна 
Published: June 2022

У статті актуалізовано питання про висвітлення в наукових і літературних джерелах побуту дитини шкільного віку як однієї з важливих складових феномену дитинства, який здійснює помітний чи прихований вплив на розвиток кожного. Стаття розглядає його і як нову наукову проблему, порівнюючи емпіричні й наукові дослідження з педагогіки дитинства, оприлюднені в науковій і художній літературі різних років. Визначено й конкретизовано поняття «побут», «побут дитини», «повсякдення», «історія повсякденності» як ключові для висвітлення заявленої теми. Головними підходами, застосовуваними для її розкриття, стали джерелознавчий пошук, історіографічний та термінологічний аналіз друкованих і електронних видань із опертям на інтегровано-міжпредметний підхід. І, як результат, було визначено, що опис побуту людини виступав метою досліджень в історичній науці, яка в останні роки почала більше цікавитися історією повсякденності, етнологією, спираючись при цьому на різноманітну джерельну базу. Коротко окресливши дослідницьке поле цієї загальної проблеми, авторка більш докладно зупиняється на розвідках, присвячених історії побуту дитини шкільного віку, починаючи з тих, що сягають кінця ХІХ ст. і до нашого часу. До цих джерел віднесено етнографічні праці, дослідження істориків, твори художньої літератури для дітей, у яких розглянуто такі аспекти дитячого побуту як життєвий/домашній простір, ігри, розваги та дозвілля, харчування та гігієна, праця, включаючи і специфічно радянський феномен побуту школярів в інтернатних/закритих закладах.
У статті розглянуто аспекти дитячого побуту, розкриті в педагогічних творах – від зосередження педології на цих питаннях до повного їх зникнення в повоєнні роки. Особлива увага приділена педагогічній спадщині В. Сухомлинського, де найбільш повно відображено побут вихованців та напрями його педагогізації, які не втратили своєї актуальності й донині.
Analisis Perilaku Penerapan Protokol Kesehatan melalui Pendekatan Health Belief Model
Authors: Dewi Dara Puspita , Adnan Nurhayati , Mabruri Ahmad Najmuddin 
Published: June 2022

Perilaku masyarakat dalam menerapkan protokol kesehatan sangat penting dalam menangani pandemi terutama selama masa-masa awal pandemi ketika belum tersedia pengobatan atau vaksinasi. Pada minggu pertama bulan Mei 2021 didapatkan bahwa tingkat kepatuhan penduduk DKI Jakarta terhadap perilaku memakai masker sebesar 77,25% dan menjaga jarak sebesar 73,27%. Kementerian Kesehatan telah mengeluarkan panduan pencegahan dan pengendalian COVID-19 di tempat kerja yang memuat tentang apa saja yang harus dilakukan oleh manajemen dan pekerja. Sebagai bahan evaluasi, rekognisi dan perencanaan kebijakan dan program penanganan Covid-19 di sektor perkantoran, diperlukan penelitian mengenai faktor risiko yang mempengaruhi perilaku pekerja perkantoran dalam penerapan protokol kesehatan pencegahan Covid-19.Penelitian menggunakan desain studi potong lintang/cross sectional dengan jumlah responden sebanyak 211 orang. Pengumpulan data dilakukan secara non-probability sampling melalui pengisian kuesioner daring kepada seluruh pekerja perkantoran.Secara umum, sebagian besar pekerja perkantoran memiliki perilaku kurang (64,93%) dalam menerapkan protokol kesehatan. Hasil penelitian menunjukkan hubungan yang tidak signifikan (p value > 0,05) antara persepsi kerentanan dan keparahan (p value 0,325), persepsi manfaat (p value 0,424), persepsi hambatan (p value 0,787) dan persepsi keyakinan diri (p value 0,255) serta cues to action (p value 0,606) pada responden dengan pengetahuan rendah terhadap perilaku individu yang kurang dalam menerapkan protokol kesehatan. Tempat kerja tetap harus memberikan pemahaman, edukasi, sosialisasi dan konseling kepada para pekerja untuk dapat meningkatkan persepsi pekerja akan manfaat melakukan perilaku pencegahan Covid-19.
Effectiveness of Aromateraphy as an Intervention for Dysmenorrhea: A Systematic Review
Authors: Elsyia Monica , Nursopa Sifa , Rosalina Sri , Hutapea Dwight Mahaputera Marulitua , Hutapea Albert Manggading 
Published: June 2022

Dysmenorrhea is not a disease, but it is a common problem that makes adolescent and adult women feel uncomfortable during menstruation which this can interfere with their daily life activities. Aromatherapy using essential oils has been commonly used for reduction of stress and anxiety and pain management. A systematic review was conducted on a publication from December 2012 to January 2018 in the International and Indonesian databases. The search terms used were aromatherapy or aroma and Dysmenorrhea or menstrual pain. Research was performed using Science Direct, Google Scholar, and ProQuest. A total of 20 articles were reviewed and analyzed for this study. A total of 20 studies showed that aromatherapy is significantly effective in reducing and eliminating dysmenorrhea, where this nonpharmacological aromatherapy massage and inhalations were found to be more effective in reducing dysmenorrhea than placebo massage. Analysis showed that aromatherapy intervention methods using essential oils (lavender, clary sage, rose, jasmine, ginger) can significantly reduce primary dysmenorrhea.
CAE studies of river ice cover aerodynamics
Authors: Lobanov Vasily A. 
Published: June 2022

The paper provides an overview of autumn-winter movements and ice breaking on river shipping routes. The range of tasks of ensuring the safety of ice navigation is highlighted, which requires the predict of wind loads on hummocky ice fields of small floe fractions. As a complex argument for the characterization of such a field, the coefficient of its windage is proposed. The statistical function of the distribution of the height of the hummocks is revealed.
To speed up the process of three-dimensional description of the geometry of the ice surface with a given law of the distribution of hummocks, the joint use of CAD and CAE systems is proposed. A series of CAE «purges» of model ice fields was carried out. The dependence of aerodynamic loads on the direction of atmospheric flow has been confirmed by the analysis of the results of CAE-modeling of wind impact on small floe ices. The conclusion is made about the limitations of the application of the classical equation of gas dynamics in relation to the studied ice.
Some Patterns of Haemostatic Parameters Among Pregnant Women with Hypertensive Disorders in Owerri, Imo State, Nigeria
Authors: Nnodim Johnkennedy , Ijeoma Okoroiwu Leticia , Dennis Nwosu , Johnkennedy Nnodim , Emeka Ilona , Chizoba Nkemka Orajiaka-Uchegbu , Ukamaka Ezechi Ruphina , Osinachi Uhiara Raphael 
Published: June 2022

Hemostatic parameters of pregnant women with hypertensive disorders in owerri were studied using standard methods. The parameters include PT, APTT, Fibrinogen, t-PA, D-dimer. A total of 200 pregnant women between ages of 18 and 45 years of age were recruited for the study. They consisted of 50 normotensive pregnant women as the control group and 150 hypertensive as the test subjects. The test group was further divided into 3 viz; 50 chronic hypertensive, 50 gestational and 50 preeclamptic pregnant women as group as groups 1, 2 and 3 respectively. The mean PT(secs.) values were 11.69±1.02, 11.98±0.94, 12.79±0.78 and 13.86±1.4 respectively, in control, groups 1, 2 and 3. The APTT(secs) mean values in control, groups 1, 2 and 3 were 28.59±2.33, 29.43±2.67, 30.20±2.73 and 31.52 respectively. The mean values obtained for D-dimer (ng/ml) were 191.72±41.92, 207.30±60.71, 249.52±62.08 and 268±59.51 in control, groups 1, 2 and 3 respectively. In control, fibrinogen (mg/ml) mean value obtained was 521.74±118.02, where as in the test groups, 532.97±111.40, 602.52±103.80 and 671.98±97.37 were respectively obtained in groups1, 2 and 3. The mean respective values of t-PA (ng/ml) in control, group 1, 2 and 3 were 2.43±0.55, 2.49±0.49, 2.84±0.54 and 2.90±0.57. All the haemostatic parameters: PT, APTT, Fibrinogen, D- dimer and t-PA values increased across the test groups when compared with the control groups and they were found to be statistically significant (P=0.0001). From this study, haemostatic parameters increased in the test subjects indicating inflammatory activities in hypertensive disorders of pregnancy.
An Extended dataset of occurrences of species listed in Resolution 6 of the Bern Convention from Ukraine
Authors: Vasyliuk Oleksii , Prylutskyi Oleh , Marushchak Oleksii , Kuzemko Anna , Kutsokon Iuliia , Nekrasova Oksana , Raes Niels , Rusin Mikhail 
Published: June 2022

The dataset includes georeferenced occurrences of species listed in Annex I of Resolution 6 of the Bern Convention and, partly, in the Red Data Book of Ukraine. The dataset was compiled within the work of NGO "Ukrainian Nature Conservation Group" aimed to prepare a Shadow list of Emerald Network (European network Areas of Special Conservation Interest) in Ukraine - newly proposed territories aimed at conservation of particular species and habitats mentioned in Resolution 4 and 6 of the Bern Convention. The list was prepared in 2017-2020 for expanding the already existing Emerald Network of Ukraine. Based on actual registrations of flora and fauna collected and gathered by scientists and naturalists in a form of dataset, which is described in the following paper.
This dataset provides information about 29,938 occurrences of species from the territory of Ukraine listed in Annex I of Resolution 6 of the Bern Convention, as well as in the Red Data Book of Ukraine. This is the largest public dataset on occurrences of rare and endangered species from Ukraine till now. Data presented here laid the foundations for the proposal of 106 approved Emerald Network sites (2019), as well as for 148 Emerald Network sites that were nominated in 2020. New insights on the endemic species Centaurea pseudoleucolepis Kleopow is provided, which was previously considered to be extinct, according to the IUCN Red List.
Analysis of factors influencing pharmaceutical sales workforce engagement in pharmaceutical marketing in Nigeria: a structural equation modeling approach
Authors: Oamen Theophilus Ehidiamen 
Published: June 2022

In the pharmaceutical sales and marketing industry, human capital in terms of the sales workforce is essential to organizational success. However, there is a need to ensure that the task-environment is adequately resourced. The application of structural equation modeling (SEM) techniques such as factor analysis is necessary to further understand the underlying relevance of these factors. The objective of the study was to explore the factors influencing pharmaceutical sales personnel's work engagement in pharmaceutical companies using factor analysis. A cross-sectional, qualitative research study used an 11-item literature-guided questionnaire administered online to 406 medical sales professionals in the pharmaceutical supply network in Nigeria using random sampling. The factors evaluated include regularity and impact of training, marketing support, job security as perceived by the employee, incentives, reward for performance, and the prospect of promotion. Others include; minimal work stress, improved career prospects, and an enabling work environment provided for employees involved in pharmaceutical sales operations. The questions were rated on a 3-point Likert scale of 1=fair, 3=poor, and 5=good, to evaluate respondents’ estimation of factors. Exploratory factor analysis (EFA) was executed on the dataset and thereafter, confirmatory factor analysis (CFA) was conducted on the dataset using SPSS AMOS. Statistical significance was set at p-value < 0.05. The majority of respondents were male (72.2%, 293) and female (27.8%, 113). Respondents from Indigenous firms were predominant (249, 61.3%) compared to Multinational firms (157, 38.7%). There were 289 (71.2%) non-pharmacists and 117 (28.8%) pharmacists. EFA measures of adequacy were satisfactory (Kaiser-Meyer-Olkin=0.878, Goodness-of-fit=0.023, Cronbach alpha=0.859, Total variance explained= 51.6%) and produced a 2-factor solution consisting of 9-items (work factors=6, implied factors=3). CFA solution from EFA output produced satisfactory fit estimates (RMSEA=0.044, CMIN/DF=1.787, GF1=0.977, AGFI=0.957, RMR=0.029, and TLI=0.981). The final model had acceptable convergent and discriminant validity values. Job security was considered as the most influential factor (regression coefficient=0.859) and the least was work-life balance (regression coefficient=0.559). The study provided a validated tool to evaluate the pharmaceutical sales workforce’s estimation of the key factors influencing job performance. This serves as an operational template for strategic managers in pharmaceutical companies to improve employee’s perception of management support.