bluuebunny/crossref_metadata_2025_split huggingface dataset:
D’une norme à l’autre
Authors: Schang-Norbelly Marie-Cécile 
Published: December 2022

La comédie mêlée d’ariettes, forme d’opéra-comique qui voit le jour dans les années 1750, est un genre hybride, qui repose sur une alternance de dialogues parlés et d’airs chantés, dont découle un mélange des registres, les ariettes favorisant l’introduction du registre pathétique au sein de la comédie. Cette absence d’unité dans les procédés induit une progression dramatique discontinue, qui repose sur la juxtaposition de situations et de tableaux, visant à saisir le spectateur. Le genre est décrié par les tenants de la doctrine classique, qui considèrent le mélange comme une imperfection et l’image comme un piège tendu aux sens du spectateur. Or, la naissance de ce genre s’inscrit dans un mouvement de réforme du théâtre qui repose, dans la deuxième moitié du xviiie siècle, sur l’idée que le mélange est l’image de la nature. Une telle conception, qui s’affranchit des codes de la représentation classique, invite à évaluer les œuvres à l’aune d’une norme nouvelle fondée sur le jugement du spectateur. Ce changement de point de vue reflète l’importance grandissante accordée à la sensibilité et à son expression au siècle des Lumières : c’est dans l’émotion du spectateur qu’il convient désormais de penser la normalité de la comédie mêlée d’ariettes.
1964-1965 : L’Annus Mirabilis de deux figures anomales, William S. Burroughs et Piero Heliczer
Authors: Haudidier Raphaël 
Published: December 2022

William S. Burroughs et Piero Heliczer furent deux protagonistes de l’underground américain des années soixante, évoluant parmi les mêmes cercles de l’avant-garde new-yorkaise. Le premier était un écrivain renommé, né à Saint-Louis, Missouri en 1914, qui vivait alors en Europe ; le second naquit dans l’Italie fasciste avant d’immigrer aux États-Unis en 1947. Tous deux étaient expatriés, tous deux étaient à la fois écrivains et artistes plastiques, voire musiciens dans le cas d’Heliczer. En outre, ils occupaient une position « anomale », selon le terme de Gilles Deleuze et Félix Guattari : ils évoluaient à la marge de l’underground et de la contre-culture, tout en ayant une grande influence sur elle. Ainsi, Burroughs fut l’un des écrivains les plus diffusés par les presses alternatives et underground des années cinquante, soixante et soixante-dix, tandis que Piero Heliczer fut éditeur indépendant, cinéaste, précurseur des spectacles multimédia warholiens, et fondateur du Velvet Underground. En dépit de cette influence majeure sur la contre-culture new-yorkaise, Piero Heliczer finit ses jours, désargenté, dans le Perche, et Burroughs, malgré une aura importante, se retira progressivement du bouillonnement intellectuel qu’il avait contribué à provoquer. Cet article analyse leurs trajectoires parallèles et leur « anomalité » en se concentrant sur l’année 1964-1965.
La loi du désir
Authors: Souquet Lionel 
Published: December 2022

Avec vingt-quatre films tournés de 1978 à 2021 et de nombreuses récompenses (trente-six prix, dont deux à Venise, deux à Cannes, quatre Césars, dix Goya et deux Oscars), Pedro Almodóvar est devenu un réalisateur incontournable et probablement le plus célèbre des cinéastes espagnols après Luis Buñuel. Il représente aussi tout un pan de l’histoire de l’Espagne puisqu’il avait vingt-six ans à la mort de Franco et qu’il est devenu l’une des figures les plus emblématiques de la Movida, le mouvement contreculturel qui s’est développé dans le pays, de 1975 au milieu des années 1980. Almodóvar a donc construit sa carrière d’artiste en rupture avec la société franquiste et ses normes : provocateur et extrêmement avant-gardiste, mais sachant aussi rendre hommage à ses aînés. Après avoir retracé les grandes étapes de la représentation du genre (masculinité, homosexualité et transsexualité) dans le cinéma franquiste (1939-1975) et postfranquiste nous verrons que, chez Almodóvar, la dysphorie de genre n’a rien d’anecdotique : elle est militante et même, plus largement, politique. Elle est aussi constitutive de l’œuvre, non seulement d’un point de vue thématique mais aussi formel, tant dans le choix d’une esthétique kitsch ou camp que dans l’élaboration d’un « gay gaze » et d’une poétique de la transparence. Nous nous intéresserons tout particulièrement à La ley del deseo / La Loi du désir (1987).
Edukasi tentang Teknik Pijat untuk Mengurangi Nyeri Haid
Authors: Wulan Ratna Dewi Sri , Sandriani  
Published: December 2022

Introduction: The impact of menstrual pain on adolescent girls includes: disturbed comfort, decreased activity, disturbed sleep patterns, disturbed appetite, relationships Interpersonal problems, difficulty concentrating on work and study. Pain too affect the emotional status of feelings, irritability, depression and anxiety. The earliest changes that occur in adolescents are physical or biological development, one of them is a teenager starting to menstruate.
Objective: students can use massage techniques to reduce menstrual pain when menstrual pain occurs.
Method: The implementation method is by counseling. This community service activity starts with (1) preparation; This stage begins with a preliminary study that aims to explore the problem of menstrual pain in Diploma Midwifery study program students, determine target activities, and plan solutions to problems. Next, they asked permission from the Head of the Diploma Midwifery Study Program to conduct outreach to students, (2) implementation. The activities are adjusted to the student mentoring schedule, (3) reporting, at this stage the team reports the results of the activities that have been carried out to the Head of Diploma Midwifery Study Program.
Result: the results of community service found that after attending counseling on massage techniques for reducing menstrual pain, students were able to apply techniques that were late in practice, although some massage techniques had to be assisted by others. After students know about massage techniques to reduce menstrual pain, some students rarely experience menstrual pain during menstruation.
Conclusion: from the results of community service about massage techniques to reduce menstrual pain, it can be concluded that there is a decrease in menstrual pain after massage techniques are carried out to reduce menstrual pain.
GIÁ TRỊ CỦA MÔ PHỎNG BẰNG CT 4D TRONG LẬP KẾ HOẠCH XẠ TRỊ UNG THƯ PHỔI KHÔNG TẾ BÀO NHỎ GIAI ĐOẠN III
Authors: Trần Đức Linh , Đặng Quang Huy , Nguyễn Đức Công 
Published: December 2022

Mục tiêu: Đánh giá sự thay đổi của các thể tích xạ trị và liều trên các cơ quan nguy cấp giữa kế hoạch dựa trên mô phỏng CT 3D và 4D. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang hồi cứu kết hợp tiến cứu trên 31 bệnh nhân (BN) ung thư phổi không tế bào nhỏ (UTPKTBN) được xạ trị tại Bệnh viện Quân y 175 từ tháng 7/2020 - 7/2022. Thể tích khối u thô được xác định trên hình ảnh CT thể tích khối u thô 3D (Gross target volume - GTV 3D) và trên 10 pha của hình ảnh CT 4D (Internal target volume - ITV hay GTV 4D) ở 31 BN UTP KTBN giai đoạn III. Kế hoạch xạ trị 3D được lập dựa trên thể tích lập kế hoạch 3D (Planning target volume - PTV), thể tích bia lâm sàng (Clinical target volume - CTV cộng biên theo hướng dẫn thường quy), kế hoạch 4D được lập dựa trên PTV 4D (CTV trên 10 pha cộng thêm sai số đặt bệnh). Các thể tích xạ trị và liều trên phổi, tim, thực quản, tủy sống được so sánh giữa kế hoạch 3D và 4D. Kết quả: Trung bình GTV 4D (111,4 ± 69,4 cm³) lớn hơn trung bình GTV 3D (77,7 ± 54,2 cm³) (p = 0,001), tuy vậy trung bình của PTV trên kế hoạch 4D (401,8 ± 167,3 cm³) lại nhỏ hơn trên kế hoạch 3D (460,2 ± 179,1 cm³) (p = 0,002). Kế hoạch 4D bảo vệ các cơ quan lành xung quanh tốt hơn 3D, đặc biệt là trên phổi. So với kế hoạch 3D, liều trung bình phổi, V5, V10, V20 của phổi giảm lần lượt từ 18,3Gy, 59,9%, 55,8%, 40,5% xuống 16,9Gy, 44,6%, 31,2%, 28,9%. Liều trung bình tim, thực quản và liều tối đa tủy sống trên kế hoạch 4D giảm so với 3D (13,1 Gy, 18,7 Gy và 37,9 Gy so với 15,8 Gy, 19,1 Gy và 40 Gy), tuy nhiên khác biệt không có ý nghĩa thống kê (p > 0,05). Kết luận: Lập kế hoạch cho BN UTPKTBN dựa trên mô phỏng bằng CT 4D giúp giảm thể tích xạ trị, bảo vệ các cơ quan lành tốt hơn mô phỏng bằng CT 3D.
Impact of Biofertilizers on Plant Growth, Physiological and Quality Traits of Lettuce (Lactuca sativa L. var. Longifolia) Grown under Salinity Stress
Authors: Yildiz Dasgan Hayriye , Temtek Tugce 
Published: December 2022

This study aims to reveal the responses of biofertilizers to the detrimental effects of salt stress on lettuce cultivation. Presidential variety lettuce seeds belonging to Syngenta company were used as plant material. Microalgae Chlorella vulgaris, beneficial bacteria, and mycorrhizal fungi are used to reduce salt damage in lettuce plants grown under salt stress. The experiment was carried out on eight different applications; (1) control, (2) salt (50 to 75 mM NaCl), (3) micro microalgae, (4) microalgae + salt, (5) bacteria (6) bacteria + salt, (7) mycorrhiza, (8) mycorrhiza + salt. The biofertilizers decreased the salt’s detrimental effects and increased the lettuce weight. Compared to salty conditions, microalgae + salt, mycorrhiza + salt, and bacteria + salt applications increased lettuce weight by 19.2, 21.3, and 20.08%, respectively. Biofertilizers increased pH, EC, total soluble solids, titratable acid, and total dry matter in lettuce leaves under salt stress. Biofertilizers had a stress-reducing effect under salinity and increased leaf osmotic potential, leaf water relative content, and leaf stomatal conductance. Microalgae Chlorella vulgaris, mycorrhiza, and beneficial bacteria are recommended as stress relievers when growing lettuce in saline agricultural soils or with saline irrigation water.
Reviews
Authors: Goddard Angela , Kielow Sabina , Trotta Joe , Malm Monica , Paul Ronald , Aaltonen Sirkku , Gamber Cayo , Todtenhaupt Martin , Nyhlén Lars-Olof 
Published: December 2022

Includes the following reviews:
pp. 228-230. Angela Goddard. Cameron, D. (ed.), The Feminist Critique of Language.
p. 230. Sabina Kielow. Fergusson, M. (ed.), Nine Black Women: An Anthology of Nineteenth Century Writers from the United States, Canada, Bermuda and the Caribbean.
pp. 230-232. Joe Trotta. Schneider, R., The Explicit Body in Performance. + Phelan, P., Mourning Sex.
pp. 232-233. Monica Malm. Scott, J.W., Kaplan, C. & Keates, D. (eds), Transitions, Environments, Translations: Feminism in International Politics.
pp. 233-234. Ronald Paul. Digby, T. (ed.), Men Doing Feminism.
pp. 234-235. Sirkku Aaltonen. Gullin, CH., Översättarens röst.
pp. 235-236. Cayo Gamber. Mintz, B. & Rothblum, E.D. (eds), Lesbians in Academia: Degrees of Freedom.
pp. 236-238. Martin Todtenhaupt. Kanz, CH. (Hgb.), Gegenwelten. Zur Geschlechterdifferenz in den Kulturwissenschaften.
pp. 238-240. Lars-Olof Nyhlén. Müller, W., Das Gegenwort-Wörterbuch. Ein Kontrastwörterbuch mit Gebrauchshinweisen.
Propeller Design Optimization: An Integral Theoretical and Experimental Procedure
Authors: Bau F. , Bellone G. , Colombo A. , Chilo B. 
Published: December 2022

This paper describes a thoroughly integrated design procedure and an example of its application, carried out in order to define the propeller of a twin screw fast ship.
As particular attention had to be paid to fulfil many contractual requirements, such as the propulsion efficiency, cavitation and related phenomenal pressures induced on the hull vibrations and noise, both lifting line and surface effect theories for the propeller design and behaviour prediction were employed. A wide program of model tests was carried out for checking· and optimizing the propeller design, so that propulsion, cavitation and noise aspects were investigated. Then a full scale optimization program was planned and carried out in order to ascertain the expected differences between model and full scale propellers behaviour.
As a final step, the optimum full scale propeller was developed and submitted to a complete experimental test program, thus obtaining all necessary data for comparing theoretically predicted, model and full scaly propeller behavior. All results deduced from the abovementioned program steps are presented and discussed in the paper where a brief description of theoretical and experimental methodologies is also given.
Timing of Dry-Docking Intervals to Most Economical Effect
Authors: Prochaska Felix 
Published: December 2022

The operational expenses in running a ship - i.e. costs for fuel, lubricating oil, capital costs, insurance, wages and maintenance - have quadrupled over the past 7 years. The price of heavy fuel oil alone is 7-fold than that of 1973.
As a result of this rapid cost escalation, ship owners were forced to re-evaluate their practices in running ships. Due to the toughened situation on the market, in many cases, the intervals between two subsequent dry-deckings had to be prolonged. A great deal of development has been done to improve the effectiveness and durability of hull coatings; however, only by keeping a ship continuously on the move, formation of marine growth and fouling can be postponed. Extending these time-spans favours the build-up of surface roughness whereby more propulsive energy is required for a longer period of time to overcome increased frictional losses. Wherever chartering contracts render it possible, a carefully timed dry-docking schedule can become an effective tool to improve operational economy.
Characterization of Chemical Constituent and Biological Activity of Roots from Cleistanthus oblonggifolius (Roxb.) Mull. Arg
Authors: Wattananon Saranya , Pompimon Wilart , Udomputtimekakul Phansuang , Maepowpan Puttinan , Taratong Thanatcha , Khamkaew Amornrat , Mookaewkrue Atchariyaporn , Boonthadang Raksina , Khamto Nopawit , Rithchumpon Puracheth , Nuntasaen Narong 
Published: December 2022

Background: C. oblongifolius is a species of Asian trees, originally described by William Roxburgh and later placed by Johannes Müller Argoviensis; it is now included in the family Phyllanthaceae. Distributed throughout Indochina and Malesia, its name in Vietnam is cọc rào; it has been recorded from the Andaman & Nicobar Islands, Australia (Queensland), Bangladesh, Borneo, Cambodia, Java, Lesser Sunda Islands, peninsular Malaysia, Maluku, Myanmar, New Guinea, Philippines, Solomon Islands, Sulawesi, Sumatera, Vietnam and Thailand. Several species of this genus are highly poisonous (C. collinus), some are brewed for treating dysentery (C. decurrens), and used for treatment of asthma (C. myrianthus).
Objective: This study was conducted to investigate the effect of crude extract and purified substance on inhibition of AIDS and cancer.
Methods: Phytochemical studies were extracts from these solvents used for the study: hexane, ethyl acetate and methanol. The dried herbs were ground and extracted by chromatography. Extracts and compound have been tested for HIV-1 RT, anti-syncytium and cytotoxicity. The obtained purification compounds were used to determine the structure by spectroscopic techniques such as UV. IR, NMR and MS.
Results: The study found that compound 3-O-methylellagic acid 4'-O-alpha-L-rhamnopyranoside from the roots of this plant, it was also found that ethyl acetate and methanol class extracts inhibited anti-HIV-1 RT up to 100% and 65% pure substance. For all extracts and purified compounds, syncytium inhibition assay showed inhibition HIV with EC50 <7.8 µM, TI>2.31. SH-SY5Y anticancer was showed with ED50 = 6.7 µM.
Conclusion: C. oblongifolius extract, most of these fractions were potent in inhibiting HIV-1 RT and syncytium (MC99+1A2) inhibition. In addition, hexane extract inhibited the growth of SH-SY5Y cancer cells more than other cancer cells. However, the isolated purified compound only had an inhibitory effect on HT-29 cells with ED50 10.11 µg/mL.
Transition of elderly men with prostate cancer: analysis of facilitating and difficulty conditions / Transição de homens idosos com câncer de próstata: análise de condicionantes facilitadores e dificultadores
Authors: Reis de Sousa Anderson , De Araújo Pricila Oliveira , Félix Meira Araújo Isabella , Sousa da Silva Rudval , Javier Vergara - Escobar Oscar , Souza de Santana Carvalho Evanilda 
Published: December 2022

Objetivo: compreender a experiência de transição de homens idosos na experiência com o câncer de próstata. Método: estudo descritivo de abordagem qualitativa realizado em quatro serviços da rede de atenção à saúde de uma cidade da Bahia, Brasil. Os dados foram coletados por meio de entrevista semiestruturada com oitenta homens idosos, as quais foram organizados e analisados com base na Técnica do Discurso do Sujeito Coletivo e interpretados à luz da Teoria das Transições. Resultados: são facilitadores a influência de familiares, amigos, outros homens, enfermeiros e demais profissionais; e dificultadores a escassez do conhecimento e recursos financeiros do indivíduo, barreiras geográficas, limitações relacionadas à estrutura e burocracia dos serviços. Considerações finais: ao construir sentidos para o câncer de próstata e admitir a vulnerabilidade, os homens confrontam suas crenças, alcançam a consciencialização que permite superar limitações e assumir o protagonismo do cuidado de si na transição da saúde/doença.
Association of Adherence to Endocrine Therapy Among Patients With Breast Cancer and Potential Drug-Drug Interactions
Authors: Rassy Elie , Bardet Aurélie , Bougacha Omar , Gantzer Laurène , Lekens Béranger , Delaloge Suzette , André Fabrice , Michiels Stefan , Pistilli Barbara 
Published: December 2022

ImportanceSuboptimal adherence to endocrine therapy (ET) among patients with hormone-receptor–positive breast cancer significantly affects survival outcomes and is associated with higher hospitalization rates and health care costs. Weak adherence to long-term treatments has multiple determinants, including disease characteristics, treatment adverse effects, and patients’ attributes, such as age and comorbidities.ObjectiveTo examine whether potential drug-drug interactions (PDDI) with tamoxifen or aromatase inhibitor were associated with adherence to ET in patients with early and advanced breast cancer.Design, Setting, and ParticipantsThis cohort study used anonymized health record data of women with breast cancer who received ET in a private observational primary care database. Patients eligible for analysis included women aged 18 years or older who had a reported diagnosis of breast cancer and received ET with tamoxifen or aromatase inhibitor between 1994 and 2021. Data were analyzed 2021.ExposuresAdherence to ET during a given year was defined by a medication possession ratio of 80% or greater over 1-year prescription periods. PDDI were categorized into absent, minor (a combination to take into account), moderate (combination requiring precautions for use), major (combination not recommended), and contraindicated according to guidelines in the Claude Bernard Drug Database.Main Outcomes and MeasuresWe used regression models to estimate odds ratios (ORs) and 95% CIs for the associations between adherence and age, baseline comorbidities, PDDI, and adherence to ET during the previous year.ResultsA total of 10 863 patients who were prescribed ET for breast cancer were eligible for the analysis (age 70 years or older, 3509 patients [32.3%]). In the tamoxifen cohort (3564 patients), PDDI were reported in 497 of 3670 patients (13.5%) at baseline (moderate, 254 patients [51.1%]; major, 227 patients [45.7%]), 2047 of 4831 patients (42.4%) at year 1, 1127 of 2751 patients (41.0%) at year 2, 761 of 1861 patients (40.9%) at year 3, 376 of 1058 patients (35.5%) at year 4, and 201 of 593 patients (33.9%) at year 5. In the aromatase inhibitor cohort (7299 patients), PDDI were reported in 592 of 7437 patients (8.0%) at baseline (moderate in 588 of 592 patients [99.3%]), which reached 2875 of 9031 patients (31.8%) at year 1 and ranged between 31.4% (1802 of 5730 patients in year 2) and 32.8% (791 of 2411 in year 4) throughout the study period. No association between adherence and PDDI was found in the tamoxifen (OR, 0.99; 95% CI, 0.91-1.08) or aromatase inhibitor (OR, 1.05; 95% CI, 0.95-1.15) cohort.Conclusions and RelevanceIn this cohort of patients with hormone-receptor–positive breast cancer, PDDI with tamoxifen and aromatase inhibitors were not associated with adherence to ET.
Incorporation of Robust NIR‐II Fluorescence Brightness and Photothermal Performance in a Single Large π‐Conjugated Molecule for Phototheranostics
Authors: Li Yuanyuan , Tang Yufu , Hu Wenbo , Wang Zhen , Li Xi , Lu Xiaomei , Chen Shufen , Huang Wei , Fan Quli 
Published: December 2022

AbstractSecond near‐infrared (NIR‐II, 1000–1700 nm) window fluorescence imaging‐guided photothermal therapy probes are promising for precise cancer phototheranostics. However, most of the currently reported probes do not demonstrate high NIR‐II fluorescent brightness (molar absorption coefficient (ε) × quantum yield (QY)) and photothermal performance (ε × photothermal conversion efficiency (PCE)) in a single molecule. Herein, a versatile strategy to solve this challenge is reported by fabricating a large π‐conjugated molecule (BNDI‐Me) with a rigid molecular skeleton and flexible side groups. The proposed BNDI‐Me nanoprobe boosts the ε and simultaneously optimizes its QY and PCE. Therefore, high NIR‐II fluorescent brightness (ε × QY = 2296 m−1 cm−1) and strong photothermal performance (ε × PCE = 82 000) are successfully incorporated in a single small molecule, and, to the best of knowledge, either of these two parameters is better than the best currently available fluorescent or photothermal probes. Thus, superior NIR‐II imaging effect in vivo and high photothermal tumor inhibition rate (81.2%) at low systemic injection doses are obtained. The work provides further insights into the relationship of photophysical mechanisms and structures, and presents promising molecular design guidelines for the integration of more efficient multiple theranostic functions in a single molecule.
Cholesterol‐24‐hydroxylase (CYP46) in the old brain: Analysis of positive populations and factors triggering its expression in astrocytes
Authors: Cataldi Gabriel G. , Elorza Setiembre D. , Toledano‐Zaragoza Ana , de Olmos Soledad , Cragnolini Andrea B. , Martín Mauricio G. 
Published: December 2022

AbstractCholesterol‐24‐hydroxylase (CYP46), a member of the cytochrome P450 superfamily of enzymes, is selectively expressed in the brain and is mainly responsible for cholesterol turnover in the central nervous system. Although increased cyp46A1 gene expression has been linked to cognitive alterations in aging and observed in neurodegenerative diseases and after traumatic brain injury, a detailed characterization of the brain regions and cell types in which CYP46 is expressed in old individuals has not been performed. Using immunohistochemistry and immunofluorescence, we investigated the specific regions and cell populations in the brain, in which cyp46A1 is expressed in 24‐month‐old mice. We found that CYP46 is localized in the same neuronal populations in young and old brains, mainly in the hippocampus, in cortical layers, and in Purkinje neurons of the cerebellum. No increase in CYP46 levels was found in astrocytes in old mice brains, in primary astrocyte‐neuron cocultures aged in vitro, or in primary cultures of senescent astrocytes. However, interleukin‐6 treatment strongly induced cyp46A1 expression in reactive astrocytes characterized by high GFAP levels but had no effect in nonactivated astrocytes. Our data suggest that cholesterol‐24‐hydroxylase expression is triggered in reactive astrocytes in response to proinflammatory signals, probably as part of a response mechanism to injury.