bluuebunny/crossref_metadata_2025_split huggingface dataset:
VEGFA rs2010963 GG genotype is associated with superior adaptations to resistance versus endurance training in the same group of healthy, young men
Authors: Boidin Maxime , Dawson Ellen A. , Thijssen Dick H. J. , Erskine Robert M. 
Published: November 2022

AbstractPurposeWe used a within-subject, cross-over study to determine the relationship between the intra-individual adaptations to four weeks’ resistance (RT)versusfour weeks’ endurance (END) training, and we investigated whether three single nucleotide polymorphisms (SNPs) were associated with these adaptations.MethodsThirty untrained, healthy, young men completed a cycling test to exhaustion to determine peak oxygen uptake (V̇O2peak), and a knee extension (KE) maximum voluntary isometric contraction (MVIC) of the right leg before and after four weeks’ supervised RT (four sets of 10 repetitions at 80% single repetition maximum unilateral KE exercise, three times weekly) and four weeks’ supervised END (30 min combined continuous/interval cycling, three times weekly), separated by a three-week washout phase. Participants were genotyped for theACTN3rs1815739,NOS3rs2070744 andVEGFArs2010963 SNPs.ResultsThe intra-individual adaptations regarding percentage changes in MVIC force and V̇O2peakfollowing RT and END, respectively, were unrelated (r2 = 0.003;P = 0.79). However, aVEGFAgenotype × training modality interaction (P = 0.007) demonstrated thatVEGFAGG homozygotes increased their MVIC force after RT (+ 20.9 ± 13.2%) more than they increased their V̇O2peakafter END (+ 8.4 ± 9.1%,P = 0.005), and more thanVEGFAC-allele carriers increased their MVIC force after RT (+ 12.2 ± 8.1%,P = 0.04). There were no genotype × training modality interactions for theACTN3orNOS3SNPs.ConclusionHigh/low responders to RT were not consequently high/low responders to END or vice versa. However, preferential adaptation ofVEGFArs2010963 GG homozygotes to RT over END, and their greater adaptation to RT compared toVEGFAC-allele carriers, indicate a novel genetic predisposition for superior RT adaptation.
Effects of exercise interventions on cancer-related fatigue in breast cancer patients: an overview of systematic reviews
Authors: Zhou Hong-Juan , Wang Tao , Xu Yong-Zhi , Chen Yan-Nan , Deng Li-Jing , Wang Chang , Chen Jin-Xiu , Tan Jing-Yu 
Published: November 2022

Abstract

Objective
This overview of systematic reviews aims to critically appraise and consolidate evidence from current systematic reviews (SRs)/meta-analyses on the effects of exercise interventions on cancer-related fatigue (CRF) in breast cancer patients.

Methods
SRs/meta-analyses that explored the effects of exercise interventions on CRF in breast cancer patients compared with the routine methods of treatment and care were retrieved from nine databases. The methodological quality of the included SRs was appraised using A MeaSurement Tool to Assess systematic Reviews II (AMSTAR II). The Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to calculate the grading of outcomes in the included SRs. The exercise type, frequency, duration, and inclusion/absence of supervision were further evaluated with subgroup analyses. The Stata 16.0 software was utilized for data analysis.

Results
Twenty-nine reviews were included. The overall methodological quality and level of evidence of the included reviews were unsatisfactory, with only three reviews rated as high methodological quality and no review identified as high-quality evidence. Moderate certainty evidence indicated that exercise could improve fatigue in breast cancer patients (SMD = − 0.40 [95%CI − 0.58, − 0.22]; P = 0.0001). Subgroup analysis based on the types of exercise showed that yoga (SMD = − 0.30 [95%CI − 0.56, − 0.05]; I2 = 28.7%) and aerobic exercise (SMD = − 0.29 [95%CI − 0.56, − 0.02]; I2 = 16%) had a significantly better effect on CRF in breast cancer patients; exercising for over 6 months (SMD = − 0.88 [95%CI − 1.59, − 0.17]; I2 = 42.7%; P = 0.0001), three times per week (SMD = − 0.77 [95%CI − 1.04, − 0.05]; I2 = 0%; P = 0.0001), and for 30 to 60 min per session (SMD = − 0.81 [95%CI − 1.15, − 0.47]; I2 = 42.3%; P = 0.0001) can contribute to a moderate improvement of CRF. Supervised exercise (SMD = − 0.48 [95%CI − 0.77, − 0.18]; I2 = 87%; P = 0.001) was shown to relieve CRF.

Conclusion
Exercise played a favorable role in alleviating CRF in breast cancer. Yoga was recommended as a promising exercise modality for CRF management in the majority of the included studies. Exercising for at least three times per week with 30 to 60 min per session could be recommended as a suitable dosage for achieving improvement in CRF. Supervised exercise was found to be more effective in alleviating CRF than unsupervised exercise. More rigorously designed clinical studies are needed to specify the exact exercise type, duration, frequency, and intensity to have an optimal effect on CRF in breast cancer patients.

Trial registration
ClinicalTrials.gov Identifier: CRD42020219866.
Loss of bone morphogenetic protein signaling in fibroblasts results in CXCL12-driven serrated polyp development
Authors: Ouahoud Sarah , Westendorp Barbara Florien , Voorneveld Philip Willen , Abudukelimu Subinuer , Koelink Pim Johan , Pascual Garcia Elena , Buuren Jessica Flora Isabella , Harryvan Tom Jacob , Lenos Kristiaan Jan , van Wezel Tom , Offerhaus Johan Arnold , Fariña-Sarasqueta Arantza , Crobach Stijn , Slingerland Marije , Hardwick James Christopher Henry , Hawinkels Lukas Jacobus Antonius Christiaan 
Published: November 2022

AbstractMutations in Bone Morphogenetic Protein (BMP) Receptor (BMPR)1A and SMAD4 are detected in 50% of juvenile polyposis syndrome (JPS) patients, who develop stroma-rich hamartomatous polyps. The established role of stromal cells in regulating BMP activity in the intestine implies a role for stromal cells in polyp development. We used conditional Cre-LoxP mice to investigate how specific loss of BMPR1A in endothelial cells, fibroblasts, or myofibroblasts/smooth muscle cells affects intestinal homeostasis. Selective loss of BMPR1A in fibroblasts causes severe histological changes in the intestines with a significant increase in stromal cell content and epithelial cell hyperproliferation, leading to numerous serrated polyps. This phenotype suggests that crucial changes occur in the fibroblast secretome that influences polyp development. Analyses of publicly available RNA expression databases identified CXCL12 as a potential candidate. RNAscope in situ hybridization showed an evident increase of Cxcl12-expressing fibroblasts. In vitro, stimulation of fibroblasts with BMPs resulted in downregulation of CXCL12, while inhibition of the BMP pathway resulted in gradual upregulation of CXCL12 over time. Moreover, neutralization of CXCL12 in vivo in the fibroblast-specific BMPR1A KO mice resulted in a significant decrease in polyp formation. Finally, in CRC patient specimens, mRNA-expression data showed that patients with high GREMLIN1 and CXCL12 expression had a significantly poorer overall survival. Significantly higher GREMLIN1, NOGGIN, and CXCL12 expression were detected in the Consensus Molecular Subtype 4 (CMS4) colorectal cancers, which are thought to arise from serrated polyps. Taken together, these data imply that fibroblast-specific BMP signaling–CXCL12 interaction could have a role in the etiology of serrated polyp formation.
Why do we need to care about transboundary aquifers and how do we solve their issues?
Authors: Rivera Alfonso , Pétré Marie-Amélie , Fraser Christina , Petersen-Perlman Jacob D. , Sanchez Rosario , Movilla Laura , Pietersen Kevin 
Published: November 2022

AbstractAs the reliance on transboundary groundwater is increasing globally, it is important to understand and address the specific issues raised by the assessment and management of transboundary aquifers (TBAs). Building on 20 years of TBA experience and through a three-pillar framework (assessment, cooperation-collaboration, shared management), the key elements to addressing TBA issues are described, including a multidisciplinary approach, identification of hotspot zones, local vs border-wide approaches, appropriate funding models, and an increased recognition of the role and value of each TBA.
Cu2O Nanoparticles Deposited on Y2O3 and CuO: Synthesis and Antimicrobial Properties
Authors: Długosz Olga , Lis Kinga , Matyjasik Wiktoria , Radomski Piotr , Pulit-Prociak Jolanta , Banach Marcin 
Published: November 2022

AbstractThis paper reports the preparation of copper(I) oxide nanoparticles deposited on yttrium oxide and copper(II) oxide in the presence of acerola and white willow extracts. Through the use of natural compounds, it was possible to modify the surface of the Y2O3 and CuO carriers allowing Cu2O to be deposited to a greater extent, thus improving the antibacterial properties of the materials. Cu2O nanoparticles, by being deposited on a carrier, enable an increase in the contact surface of the nanoparticles with microorganisms, which react to form reactive oxygen species. Cu2O nanoparticles with sizes of about 38 nm and 76 nm were obtained for Y2O3- and CuO-deposited nanoparticles, respectively. The Gram-negative bacteria Escherichia coli shown a greater sensitivity to the degree of inhibition compared to Staphylococcus Aureus already at a concentration of 250 mg/L. For almost all materials, the inhibition level remained above 50% after 48 h. Analysis of the effect of the antimicrobial properties of the materials against Candida albicans fungus shown high activity which was obtained only at the highest concentrations of 8000 mg/L, for which the degree of growth inhibition was 100% also after 48 h for both Y2O3–Cu2O and CuO–Cu2O.
Improving Health and Diabetes Self-Management in Immigrants with Type 2 Diabetes Through a Co-Created Diabetes Self-Management Education and Support Intervention
Authors: Hempler Nana Folmann , Fagt Charlotte , Olesen Kasper , Wagner Sabina , Rasmussen Lone Banke , Laursen Ditte Hjorth , Glümer Charlotte , Nygaard Mette , Willaing Ingrid 
Published: November 2022

AbstractTo examine the impact of a co-created culturally sensitive diabetes self-management education and support (DSMES) intervention on the physical and mental health of immigrants with type 2 diabetes (T2D). Pre- and post-test among people with T2D whose primary language was Urdu, Arabic or Turkish (n = 97). Participants were offered a six-week intervention based on a person-centred approach using research-based dialogue tools to facilitate learning and reflection, which was developed in co-creation with immigrants and healthcare professionals. Data were collected at baseline, post-intervention and after 6 months and analysed using paired t-tests, Wilcoxon signed-rank tests, chi-square tests and regression models when appropriate. Several clinical outcomes were improved post-intervention, including HbA1c (P < 0.001), body fat percentage (P = 0.002), self-rated general health (P = 0.05), well-being (P = 0.004) and several self-management behaviours, e.g., physical activity (P < 0.001). Most outcomes remained improved after 6 months, but the effect on HbA1c was no longer statistically significant. Some outcomes were improved only at 6 months, including waist circumference (P < 0.001) and diabetes-related emotional distress (P < 0.001). Fatigue did not change. Attendance at more programme sessions was associated with better outcomes. The DSMES intervention developed in a co-creation process was highly effective in improving the health of immigrants with T2D.
The impact of pharmacist-led medication reconciliation and interprofessional ward rounds on drug-related problems at hospital discharge
Authors: Studer Helene , Imfeld-Isenegger Tamara L. , Beeler Patrick E. , Ceppi Marco G. , Rosen Christoph , Bodmer Michael , Boeni Fabienne , Hersberger Kurt E. , Lampert Markus L. 
Published: November 2022

Abstract
Background
During transitions of care, including hospital discharge, patients are at risk of drug-related problems (DRPs).

Aim
To investigate the impact of pharmacist-led services, specifically medication reconciliation at admission and/or interprofessional ward rounds on the number of DRPs at discharge.

Method
In this retrospective, single-center cohort study, we analyzed routinely collected data of patients discharged from internal medicine wards of a regional Swiss hospital that filled their discharge prescriptions in the hospital’s community pharmacy between June 2016 and May 2019. Patients receiving one of the two or both pharmacist-led services (Study groups: Best Care = both services; MedRec = medication reconciliation at admission; Ward Round = interprofessional ward round), were compared to patients receiving standard care (Standard Care group). Standard care included medication history taken by a physician and regular ward rounds (physicians and nurses). At discharge, pharmacists reviewed discharge prescriptions filled at the hospital’s community pharmacy and documented all DRPs. Multivariable Poisson regression analyzed the independent effects of medication reconciliation and interprofessional ward rounds as single or combined service on the frequency of DRPs.

Results
Overall, 4545 patients with 6072 hospital stays were included in the analysis (Best Care n = 72 hospital stays, MedRec n = 232, Ward Round n = 1262, and Standard Care n = 4506). In 1352 stays (22.3%) one or more DRPs were detected at hospital discharge. The combination of the two pharmacist-led services was associated with statistically significantly less DRPs compared to standard care (relative risk: 0.33; 95% confidence interval: 0.16, 0.65). Pharmacist-led medication reconciliation alone showed a trend towards fewer DRPs (relative risk: 0.75; 95% confidence interval: 0.54, 1.03).

Conclusion
Our results support the implementation of pharmacist-led medication reconciliation at admission in combination with interprofessional ward rounds to reduce the number of DRPs at hospital discharge.
Exposure to persistent organic pollutants alters the serum metabolome in non-obese diabetic mice
Authors: Sinioja Tim , Bodin Johanna , Duberg Daniel , Dirven Hubert , Berntsen Hanne Friis , Zimmer Karin , Nygaard Unni C. , Orešič Matej , Hyötyläinen Tuulia 
Published: November 2022

Abstract
Introduction
Autoimmune disorders such as type 1 diabetes (T1D) are believed to be caused by the interplay between several genetic and environmental factors. Elucidation of the role of environmental factors in metabolic and immune dysfunction leading to autoimmune disease is not yet well characterized.

Objectives
Here we investigated the impact of exposure to a mixture of persistent organic pollutants (POPs) on the metabolome in non-obese diabetic (NOD) mice, an experimental model of T1D. The mixture contained organochlorides, organobromides, and per- and polyfluoroalkyl substances (PFAS).

Methods
Analysis of molecular lipids (lipidomics) and bile acids in serum samples was performed by UPLC-Q-TOF/MS, while polar metabolites were analyzed by GC-Q-TOF/MS.

Results
Experimental exposure to the POP mixture in these mice led to several metabolic changes, which were similar to those previously reported as associated with PFAS exposure, as well as risk of T1D in human studies. This included an increase in the levels of sugar derivatives, triacylglycerols and lithocholic acid, and a decrease in long chain fatty acids and several lipid classes, including phosphatidylcholines, lysophosphatidylcholines and sphingomyelins.

Conclusion
Taken together, our study demonstrates that exposure to POPs results in an altered metabolic signature previously associated with autoimmunity.
Factor Structure and Measurement Invariance of the Spanish Burnout Inventory Among Professionals Across 17 Countries and Regions
Authors: Gil-Monte Pedro R. , Espejo Begoña , Checa Irene , Gil-LaOrden Pedro , Angeline J Kezia , Carlotto Mary Sandra , Converso Daniela , Deroncele-Acosta Ángel , Figueiredo-Ferraz Hugo , Galarza Laura , Gómez-Ortiz Viviola , Grau-Alberola Ester , Labarthe Javier , Llorca-Pellicer Marta , Mekala V Christy , Misiolek-Marín Alejandra , Román-Cao Eldis , Salas-Blas Edwin , Schoenenberger Sandrine , Unda-Rojas Sara , Viotti Sara 
Published: November 2022

AbstractStudies on the prevalence of burnout in professionals in service organizations who work in direct contact with the clients or users of the organization have concluded that burnout is a serious health disorder that has increased due to the COVID-19 pandemic. A significant advantage of the Spanish Burnout Inventory (SBI) over other instruments is that it provides a broader conceptualization of burnout by including feelings of guilt as a dimension of burnout to explain its development. However, the measurement invariance of the SBI across countries has not been investigated. The purpose of this study was to test the measurement invariance of the SBI among professionals across 17 countries and regions in Europe, Latin America, and Asia, and in different languages. All the countries showed a good fit to the four-factor model, except the Indian sample, which was excluded from the measurement invariance study. Using the alignment method, it was possible to verify the scalar measurement invariance of the four SBI factors across 15 countries and one Spanish region (16 samples). The comparison of estimated latent means indicates that France is the country with the lowest scores on the Enthusiasm factor and the highest scores on the negative factors (Exhaustion, Indolence, and Guilt). In contrast, the Andean countries, Colombia, Peru, and Ecuador, show the highest latent means on the Enthusiasm factor and the lowest means on the negative factors. These results support the validity of the SBI in the countries and regions in Europe and Latin America included in this study.
E-commerce Policy and the Global Economy: A Path to More Inclusive Development?
Authors: Ahi Alan A. , Sinkovics Noemi , Sinkovics Rudolf R. 
Published: November 2022

AbstractThe advancement of digitalization is gradually transforming the existing structure of the global economy. According to the McKinsey Global Institute, almost all cross-border transactions had a digital component in 2016. This is also reflected by the growing literature on digitalization and E-commerce. Yet, studies specifically focusing on E-commerce policy are scarce compared with other areas in this domain. By going beyond academic articles and including policy documents in our analysis, this study takes stock of the issues as well as the policy recommendations identified in these publications. Our analysis reveals that to promote an inclusive E-commerce participation, it is imperative to design policies that improve countries’ formal institutions, facilitate the inclusion of less-developed countries in the E-commerce space, and enhance E-commerce adoption by small- and medium-sized enterprises. We highlight the significance of collaboration between and solidarity among governments and other stakeholders.
Surface Oxidation and Wettability of Fe–Mn and Fe–Mn–Si-Alloyed Steel After Annealing
Authors: You Yuliu , Kim Jungki , Kwakernaak Cees , Brouwer Johannes C. , Westerwaal Ruud , Sloof Willem G. 
Published: November 2022

Abstract
The surface oxidation and wettability of Mn and Si-alloyed steel after annealing at different conditions are studied with scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), and a so-called de-wetting method. After exposure at 950 °C for 1 hour in an Ar + 5 vol pct H2 gas atmosphere with dew points (DP) ranging from – 40 °C to 10 °C, oxides were observed along the grain boundaries or dispersed on the surface for the Fe–1.8 Mn steels while a continuous oxides layer was formed on Fe–1.9 Mn–0.94 Si steels (composition in weight fractions). The oxides formed at different DPs were predicted based on thermodynamic calculations. (Fe,Mn)O was formed on Fe–1.8 Mn steel at the whole range of DPs, while the oxide phase on Fe–1.9 Mn–0.94 Si steel depends on the DP. At low-DP SiO2 were formed and with increasing the DP (Fe,Mn)SiO3 or (Fe,Mn)SiO3 + (Fe,Mn)2SiO4 were formed and finally (Fe,Mn)2SiO4 were formed. An increase of the fraction of Fe in the oxide with increasing DP for both steels was observed with XPS analysis. As a measure for the surface wettability, the contact angle of Pb droplets on the annealed steels surfaces was determined with SEM and image analysis software. Also, the contact angle of Pb on pure Fe and on the Mn and Si alloyed steels free of surface oxides was measured for comparison. The results show that the contact angle of Pb on the steel surfaces after annealing decreases with increasing DP. This improved wettability with increasing dew point is related to the Fe fraction of the oxides formed on the surface.
Minimum Wage Effects on Reservation Wages
Authors: Sousounis Panos , Lanot Gauthier 
Published: November 2022

AbstractReservation wages are part of the transmission mechanism between minimum wages and unemployment via the labour force participation decision. The limited available empirical evidence on the relationship between reservation wages and legal minimum wages suggest that individuals use minimum wages as benchmarks against which their reservation wages are set. This has a profound behavioural effect that may encourage individuals to either enter the labour force or price themselves out of potential employment. We employ a fuzzy regression discontinuity design to explore the influence of minimum wages on reservation wages. Our findings suggest that the behavioural response is too small to be extracted from the variability of the reservation wage data. For policy makers this finding is important. While minimum wages raise earnings and living standards, they can push some workers out of the labour force by increasing their reservation wage beyond the minimum. We do not find any evidence of such a response of the reservation wage of jobseekers to the minimum wage in the UK.
The Transboundary Approach to Landscape Geointerpretation: Challenges in Interpretive Planning and Geoconservation
Authors: Breg Valjavec M. , Dunato Pejnović N. , Draženović M. , Čonč Š. , Polajnar Horvat K. 
Published: November 2022

Abstract The paper introduces the transboundary approach for landscape geointerpretation using a karst landscape (NW Dinaric Karst) as an example. It proposes geointerpretation that focuses on attractive geoheritage themes that are unique to a karst landscape, such as “duality” of the landscape (surface and underground landscape), geodiversity and geohistory of explorations. Four representative karst landscape types are presented in two neighbouring countries, Slovenia (SI) and Croatia (HR): low karst (Karst Plateau/SI), contact karst (UNESCO site Škocjan Caves/ SI), high alpine glacial karst (Gorski Kotar/HR) and coastal karst (Island of Krk/HR). The transboundary geointerpretation approach is based on an interpretive planning process, which was conducted through participatory workshops with local people and stakeholders and resulted in one interpretive master plan and four permanent exhibition plans. The key phenomena and themes for permanent exhibition plans were identified and used as the basis for the establishment of off-site karst interpretive centres and on-site polygons. The karst heritage was interpreted by using Freeman Tilden’s basic principles of interpretation. The presented approach and the interpretive infrastructure provide a good basis for further geoconservation projects, as well as for geopark designation. Its transferability and further geotourism applications are discussed.