bluuebunny/crossref_metadata_2025_split huggingface dataset:
У пошуках ключа успіху України на світових ринках
Authors: Вірченко Оксана Олександрівна , Романчук Катерина Василівна , Шиманська Катерина Володимирівна 
Published: January 2022

Проаналізовано позиції України серед країн ЄС за показником готовності до майбутнього виробництва (за складовими: складність та структура виробництва, та драйверами: людський капітал та ресурси сталого розвитку) для визначення потенційної конкурентоспроможності України у процесі інтеграції у таке об’єднання та окреслення можливих шляхів її підвищення. У дослідженні використано загальнонаукові методи пізнання, зокрема, систематизацію, порівняння, аналіз та синтез. У процесі дослідження проаналізовано окремі компоненти інтегральної оцінки готовності України до виробництва майбутнього в компаративному аспекті (за складовими: складність та структура виробництва, та драйверами: людський капітал та ресурси сталого розвитку); визначено питання, які потребують першочергового вирішення з метою нарощення конкурентних переваг України на світових ринках і спроможності протистояти ризикам та викликам майбутнього; окреслено напрями подальших досліджень. Теоретичне значення дослідження полягає у розвитку (прирості) наукового знання щодо факторів, за якими оцінюється готовність країни протистояти ризикам і викликам майбутнього у глобалізованому світі та їх впливу на формування конкурентоспроможності України. Практичне значення отриманих у дослідженні результатів полягає у можливості використання урядом України, науковою спільнотою та неурядовими організаціями ідентифікованих у дослідженні проблемних точок, за якими існують розриви для розробки стратегії та заходів її реалізації, яка дасть можливість активізути їх відповідно до значень, рівних або наближених до значень країн-членів ЄС. Наукова новизна дослідження полягає у розвитку підходу щодо ідентифікації конкурентних переваг України на світових ринках через компаративний аналіз вибраних показників з країнами ЄС з огляду на готовність протистояти ризикам та викликам майбутнього.
СТАЛИЙ РОЗВИТОК ВИЩОЇ ОСВІТИ: СУЧАСНІ ТЕНДЕНЦІЇ
Authors: Давидов П. Г. , Цибулько О. С. , Харламов М. І. 
Published: January 2022

У статті охарактеризовано сучасні тенденції розвитку вищої освіти, враховуючи домінантну роль концепції сталого розвитку. Оскільки освіта є невід’ємною частиною сучасного світу і покликана забезпечувати потреби різних і численних членів суспільства, функції і роль освіти також важливі і значні. У найбільш загальному вигляді роль освіти у суспільстві полягає у соціалізації та інкультурації його членів, тобто прилученні до культури. Саме освіта забезпечує передачу загальнозначимих знань та концептів соціального досвіду, моральних цінностей та етичних норм від старших поколінь до молодших. Не менш значущі інші функції освіти: комунікативна і когнітивна. Комунікація за допомогою освіти відбувається більш цілеспрямовано та індивідуалізовано, ніж через засоби масової інформації, друковані та електронні, або через виразні засоби, властиві різним жанрам мистецтва. Нарешті, когнітивна функція освіти полягає у сприянні пізнанню світу, передачі інформації.
У сучасних умовах, коли суттєво зростають цілісність, складність та інтеграційний потенціал світової спільноти, рівень антропогенного впливу на навколишнє середовище, а також масштаби та темпи соціальних змін, будь-яке, навіть невелике відставання в людському розвитку може викликати дуже несприятливі наслідки. Саме освіта покликана не допустити цього розриву у темпах змін. Відповіддю освітньої системи на цю потребу сучасного світу стає формування цілісного світогляду, що передбачає новий спосіб мислення, а значить – і дії людини, яка знає, розуміє суспільство, вміє жити в сучасному світі з його різноманіттям культур і стилів життя, долає власні стереотипи, усвідомлює довгострокові наслідки своєї діяльності та здатна дати адекватну оцінку актуальним процесам життя.
Отже, означені у статті тенденції сучасного розвитку системи вищої освіти виштовхують до нової парадигми освіти, ключову роль у якій відіграє інтеграція, комунікація та поліструктурність. Відкритість системи вищої освіти виявляється в постійному оновленні та сприйнятті нових викликів, що і є перспективою подальших досліджень.
The Body in Arabic Love Poetry
Authors: Alharthi Jokha 
Published: January 2022

This book radically re-interprets the nature of medieval Arabic love poetry in the classical age. It challenges stereotypical ideas about the absence of the body in ʿUdhri love poetry. Investigating the ʿUdhri tradition through close readings of the classical 10th-century Arabic sources including anthologies such as the Kitab al-Aghani, the book contributes to literary studies on the representations of the body. It also includes close readings of difficult literary texts in classical Arabic including the work of ʿUrwah b. Hizam, Majnun Layla, Qays b. Dharih, Jamil Buthaynah and Kuthayyir ʿAzzah.
The author re-appraises the relationship between love, poetry and Arab society in the 8th to 11th centuries. She avoids familiar clichés about the purity of love in ‘Udhri poetry. Broadly speaking, this book is an Arabic counterpart to the western medieval concept of unconsummated courtly love. It questions the traditional much-vaunted emphasis on chastity and the assumption that this poetry omits any concept of the body.
Regeneration of Jaw Joint Cartilage in Adult Zebrafish
Authors: Smeeton Joanna , Natarajan Natasha , Anderson Troy , Tseng Kuo-Chang , Fabian Peter , Crump J. Gage 
Published: January 2022

The poor intrinsic repair capacity of mammalian joint cartilage likely contributes to the high incidence of arthritis worldwide. Adult zebrafish can regenerate many structures that show limited or no healing capacity in mammals, including the jawbone. To test whether zebrafish can also regenerate damaged joints, we developed a surgical injury model in which the zebrafish jaw joint is destabilized via transection of the major jaw joint ligament, the interopercular–mandibular (IOM). Unilateral transection of the IOM ligament in 1-year-old fish resulted in an initial reduction of jaw joint cartilage by 14 days, with full regeneration of joint cartilage by 28 days. Joint cartilage regeneration involves the re-entry of articular chondrocytes into the cell cycle and the upregulated expression of sox10, a marker of developing chondrocytes in the embryo that becomes restricted to a subset of joint chondrocytes in adults. Genetic ablation of these sox10-expressing chondrocytes shows that they are essential for joint cartilage regeneration. To uncover the potential source of new chondrocytes during joint regeneration, we performed single-cell RNA sequencing of the uninjured adult jaw joint and identified multiple skeletal, connective tissue, and fibroblast subtypes. In particular, we uncovered a joint-specific periosteal population expressing coch and grem1a, with the jaw joint chondrocytes marked by grem1a expression during regeneration. Our findings demonstrate the capacity of zebrafish to regenerate adult joint cartilage and identify candidate cell types that can be tested for their roles in regenerative response.
Investigating Molecular Signatures Underlying Trapeziometacarpal Osteoarthritis Through the Evaluation of Systemic Cytokine Expression
Authors: Ratneswaran Anusha , Rockel Jason S. , Antflek Daniel , Matelski John J. , Shestopaloff Konstantin , Kapoor Mohit , Baltzer Heather 
Published: January 2022

PurposeNon-operative management of trapeziometacarpal osteoarthritis (TMOA) demonstrates only short-term symptomatic alleviation, and no approved disease modifying drugs exist to treat this condition. A key issue in these patients is that radiographic disease severity can be discordant with patient reported pain, illustrating the need to identify molecular mediators of disease. This study characterizes the biochemical profile of TMOA patients to elucidate molecular mechanisms driving TMOA progression.MethodsPlasma from patients with symptomatic TMOA undergoing surgical (n=39) or non-surgical management (n=44) with 1-year post-surgical follow-up were compared using a targeted panel of 27 cytokines. Radiographic (Eaton-Littler), anthropometric, longitudinal pain (VAS, TASD, quick DASH) and functional (key pinch, grip strength) data were used to evaluate relationships between structure, pain, and systemic cytokine expression. Principal Component Analysis was used to identify clusters of patients.ResultsPatients undergoing surgery had greater BMI as well as higher baseline quick DASH, TASD scores. Systemically, these patients could only be distinguished by differing levels of Interleukin-7 (IL-7), with an adjusted odds ratio of 0.22 for surgery for those with increased levels of this cytokine. Interestingly, PCA analysis of all patients (regardless of surgical status) identified a subset of patients with an “inflammatory” phenotype, as defined by a unique molecular signature consisting of thirteen cytokines.ConclusionOverall, this study demonstrated that circulating cytokines are capable of distinguishing TMOA disease severity, and identified IL-7 as a target capable of differentiating disease severity with higher levels associated with a decreased likelihood of TMOA needing surgical intervention. It also identified a cluster of patients who segregate based on a molecular signature of select cytokines.
A Systematic Analysis on the Genes and Their Interaction Underlying the Comorbidity of Alzheimer's Disease and Major Depressive Disorder
Authors: Guo Pan , Chen Shasha , Wang Hao , Wang Yaogang , Wang Ju 
Published: January 2022

BackgroundDuring the past years, clinical and epidemiological studies have indicated a close relationship between Alzheimer's disease (AD) and other mental disorders like major depressive disorder (MDD). At the same time, a number of genes genetically associated with AD or MDD have been detected. However, our knowledge on the mechanisms that link the two disorders is still incomplete, and controversies exist. In such a situation, a systematic analysis on these genes could provide clues to understand the molecular features of two disorders and their comorbidity.MethodsIn this study, we compiled the genes reported to be associated with AD or MDD by a comprehensive search of human genetic studies and genes curated in disease-related database. Then, we investigated the features of the shared genes between AD and MDD using the functional enrichment analysis. Furthermore, the major biochemical pathways enriched in the AD- or MDD-associated genes were identified, and the cross talks between the pathways were analyzed. In addition, novel candidate genes related to AD and MDD were predicted in the context of human protein-protein interactome.ResultsWe obtained 650 AD-associated genes, 447 MDD-associated genes, and 77 shared genes between AD and MDD. The functional analysis revealed that biological processes involved in cognition, neural development, synaptic transmission, and immune-related processes were enriched in the common genes, indicating a complex mechanism underlying the comorbidity of the two diseases. In addition, we conducted the pathway enrichment analysis and found 102 shared pathways between AD and MDD, which involved in neuronal development, endocrine, cell growth, and immune response. By using the pathway cross-talk analysis, we found that these pathways could be roughly clustered into four modules, i.e., the immune response-related module, the neurodevelopmental module, the cancer or cell growth module, and the endocrine module. Furthermore, we obtained 37 novel candidate genes potentially related to AD and MDD with node degrees &gt; 5.0 by mapping the shared genes to human protein-protein interaction network (PPIN). Finally, we found that 37 novel candidate genes are significantly expressed in the brain.ConclusionThese results indicated shared biological processes and pathways between AD and MDD and provided hints for the comorbidity of AD and MDD.
Active Middle Ear Implant Evoked Auditory Brainstem Response Intensity-Latency Characteristics
Authors: Fröhlich Laura , Müller Alexander , Kropp Miriam H. , Mir-Salim Parwis , Dziemba Oliver , Oberhoffner Tobias , Plontke Stefan K. , Rahne Torsten 
Published: January 2022

ObjectiveTo analyze intensity-latency functions of intraoperative auditory evoked brainstem responses (ABRs) to stimulation by the Vibrant Soundbridge (VSB) active middle ear implant with respect to coupling efficiency, VSB evoked ABR thresholds, and coupling modality [oval window (OW) placement vs. Incus placement and vs. round window (RW) placement].Study DesignExploratory study.SettingBi-centric study at tertiary referral centers.PatientsTwenty-four patients (10 female, 14 male, mean age: 58 years) who received a VSB.Outcome MeasuresWave-V intensity-latency functions of intraoperative VSB evoked ABRs using a modified audio processor programmed to preoperative bone conduction thresholds for stimulation. Threshold level correction to coupling efficiency and ABR thresholds. Individual plots and exponential function fits.ResultsAfter ABR threshold level correction, the latency functions could be aligned. A large variance of latencies was observed at individual threshold level. Wave-V latency was longest in the Incus placement subgroup (9.73 ms, SD: 1.04) as compared to OW placement subgroup (9.47 ms, SD: 1.05), with the shortest latency in the RW placement subgroup (8.99 ms, SD: 0.68). For increasing stimulation levels, the variance decreased with intensity-latency function slopes converging toward a steady-state (saturation) latency caused by saturation of audio processor (stimulation) gain. Latency saturation was reached at a stimulation level of 50 dB nHL for the OW placement subgroup, 35 dB nHL for the Incus placement subgroup, and 30 dB nHL for the RW placement subgroup. The latency and saturation results indicated decreased dynamic range for RW placement, i.e., reverse stimulation.ConclusionsVSB evoked ABR wave-V intensity-latency function slopes were similar to acoustic stimulation at high stimulation levels with a shift toward longer latencies caused by audio processor signal delay. Saturation of latencies occurred for higher stimulation levels due to saturation of audio processor gain. Thus, the analysis of VSB evoked intensity-latency functions appears to allow for the objective assessment of a patient's individual dynamic range. This can further improve diagnostics as well as intraoperative and postoperative quality control.
Morphological and Hemodynamic Characteristics Associated With the Rupture of Multiple Intracranial Aneurysms
Authors: Tang Xiaoyu , Zhou Longjiang , Wen Lili , Wu Qi , Leng Xiaochang , Xiang Jianping , Zhang Xin 
Published: January 2022

Background and PurposeThe objective of this study was to identify the morphological and hemodynamic factors associated with the rupture of multiple intracranial aneurysms regardless of patient-related factors and establish a statistical model for aneurysm rupture risk assessment.MethodsThe digital subtraction angiography (DSA) data of 104 mirror intracranial aneurysms in 52 consecutive patients were retrospectively analyzed in this study. 21 morphological parameters and hemodynamic parameters were calculated by 3-dimensional reconstruction and computational fluid dynamics (CFD) simulation. Significant differences (p &lt; 0.05) between the two groups were subsequently tested with the multivariate logistic regression to identify the independent risk factors. A prediction model was established based on the independent risk factors. The receiver operating characteristics (ROCs) were generated to estimate the prediction performance. A cohort of patients with multiple intracranial aneurysms admitted in our institute from January 2021 to October 2021 was introduced to verify the value of the model.ResultsSignificant differences between the ruptured and unruptured aneurysms were found in 15 out of 19 parameters. Bleb formation, neck width, and size ratio were independent factors in the multivariate logistic regression. A prediction model based on the three independent risk factors was established: Odds = −1.495 – 0.707 × (Neckwidth) + 3.061 × (Blebformation) + 2.1 × (SR) (bleb formation: Yes = 1, No = 0). The area under the curve (AUC) value of the model was 0.901. In the validation cohort, the prediction model showed satisfying performance in assessing multiple aneurysm rupture risk with a sensitivity of 100% and specificity of 88.46%.ConclusionBleb formation, neck width, and size ratio were independently associated with aneurysm rupture status. The prediction model may help in identifying the aneurysm with high rupture risk.
Efficacy and Safety of Chinese Herbal Medicine Xiao Yao San in Functional Gastrointestinal Disorders: A meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials
Authors: Liu Qian , Shi Zongming , Zhang Tao , Jiang Tianyuan , Luo Xiaoying , Su Xiaolan , Yang Yang , Wei Wei 
Published: January 2022

Background and Aims: Functional gastrointestinal disorders are now named disorders of gut-brain interaction (DGBI) according to the Rome IV criteria, characterized by the interaction of gastrointestinal symptoms and dysregulation of central nervous systems. Xiao-Yao-San (XYS) is effective in the treatment of gastrointestinal symptoms in China, especially in patients with concurrent mood disorders. A meta-analysis was designed to evaluate the efficacy and safety of Xiao-Yao-San for FGIDs.Methods: We searched randomized controlled trials in seven databases from their inception till November 22, 2021. Pooled analysis included therapeutic efficacy, symptom score, Self-Rating Anxiety Scale (SAS) score, Self-Rating Depression Scale (SDS) score, and the recurrence rate. Conventional meta-analysis with random-effects model or fixed-effects model and trial sequential analysis (TSA) were performed.Results: A total of 48 RCTs were eligible for inclusion (n = 4,403). Meta-analysis results showed that XYS could improve the effective rate of FGIDs compared with western drugs [RR = 1.23; (95%CI, 1.19–1.27); p &lt; 0.00001], and XYS combined with western medicine could also improve the effective rate [RR = 1.26; (95%CI, 1.21–1.33); p &lt; 0.00001]. In addition, XYS could reduce the symptom score [SMD = −1.07; (95%CI −1.42, -0.72); Z = 6.03; p &lt; 0.00001], SAS score [MD = −6.24; (95%CI −7.48, −4.99); Z = 9.81; p &lt; 0.00001] and SDS score [MD = -6.70; (95%CI −8.18, −5.21); Z = 8.83; p &lt; 0.00001] of FGIDs patients, and reduce the recurrence rate [MD = -6.70; (95%CI −8.18, −5.21); Z = 8.83; p &lt; 0.00001]. XYS was safe in most cases and no serious adverse events were observed in any of the included trials. TAS showed adequate “information size” for the primary outcome, and further confirmed the efficacy of XYS in the treatment of FGIDs.Conclusion: XYS could improve symptoms and reduce recurrence rates in FGIDs patients, and XYS may be a potential candidate for the treatment of FGIDs. However, due to the limited quality of current studies, more long-term, randomized, double-blinded clinical trials are needed in future studies.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=284308, identifier CRD42021284308.
Efficacy of Artificial Intelligence-Assisted Psychotherapy in Patients With Anxiety Disorders: A Prospective, National Multicenter Randomized Controlled Trial Protocol
Authors: Su Shanshan , Wang Yuan , Jiang Wenhui , Zhao Wenqing , Gao Rui , Wu Yanru , Tao Jing , Su Yousong , Zhang Jie , Li Kangzheng , Zhang Zhuojun , Zhao Min , Wang Zhen , Luo Yanli , Huang Xiao , Wang Lanlan , Wang Xiaoping , Li Yi , Jia Qiufang , Wang Lianzi , Li Huafang , Huang Jingjing , Qiu Jianyin , Xu Yifeng 
Published: January 2022

BackgroundAnxiety disorders have the highest prevalence of all psychiatric disorders in China. Medication and psychotherapy are two main treatment approaches for this group of disorders, and when used in combinations are significantly more beneficial than medication alone. The resources are insufficient. The availability of psychotherapy is low due to the limited resources. Artificial intelligence (AI)-assisted psychotherapy offers an opportunity to develop an efficient and standardized psychotherapy model and improve the availability of psychotherapy, which is key to improve the clinical efficacy of anxiety disorder treatments.ObjectivesThe present protocol aims to determine whether medication plus AI-assisted psychotherapy has greater efficacy than medication alone in the treatment of anxiety disorders.MethodsWe will recruit patients in eight hospitals in China. Seven hundred and eight patients with anxiety disorders will be randomly allocated on a 1:1 basis to either medication plus AI-assisted psychotherapy group, or medication alone group. We have built an AI psychotherapy robot named XIAO AN. In this study we will deliver psychotherapy to patients in the medication plus AI-assisted psychotherapy group. Patients will be assessed at baseline and at the end of week 2, 4, 8, and 12. Follow-up assessments will be conducted at 3 and 6 months posttreatment. The primary outcome is change of Hamilton Anxiety Rating Scale (HAMA) score from baseline the end of 12-week treatment. A secondary efficacy outcome will be improvement in treatment at an early stage (score reduction in HAMA ≥25% after 2 weeks of treatment). Other measurements include Hamilton Depression Scale, Clinical Global Impression, Treatment Emergent Symptom Scale, Social Disability Screening Schedule, Insomnia Severity Index and so on. Scales will be assessed by independent raters who are blind to treatment allocation and analyses will be conducted by a statistician who is also blind to treatment allocation.DiscussionThis will be the first multicentered randomized controlled single-blind trial in China to assess the efficacy of medication plus AI-assisted psychotherapy compared with medication alone for anxiety disorders. The study has the potential to address the limitations of the limited availability of psychotherapy, and to augment the efficacy of the treatment of anxiety disorders in China.
Electronic structure and optical properties of NaSi
Authors: Imai Motoharu , Yamada Takahiro , Yamane Hisanori 
Published: January 2022

Abstract
The electronic structure and optical properties of NaSi were investigated using first-principles calculations and diffuse reflectance measurements. The calculation indicates that NaSi is an indirect band gap semiconductor whose valence band maxima and conduction band minima are located at a k-point between the Γ and X points and at the Y point, respectively. NaSi has several direct band gaps, which are approximately 0.1 eV larger than the indirect band gap, leading to its large optical absorption coefficient near the indirect band gap. The valence bands originate from Si-3p states and the conduction bands from the Si-3s, Si-3p, Na-3s, and Na-3p states. Diffuse reflectance measurements revealed that NaSi has a band gap of 1.63 eV, which is comparable to the band gap calculated using HSE06 (1.68 eV).