bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application Research on Sensors and Detection Technology in Mechatronics System
Authors: Lu Yujiao 
Published: July 2022

Abstract
Sensors and detection technology play a very important role in the industrial control industry. Sensors play a pivotal role in various intelligent equipment. Sensors are divided into a variety of sensors. Reasonable sensor components can be used according to the actual situation of the application. However, the application of sensors and detection technology in mechatronics systems is very common, so this research work aims to focus on the analysis of sensors and detection technology, and to study the application of this technology in mechatronics control systems. In the final phase of this research, a future analysis of the application status of sensors and detection technologies is carried out. It aims to provide the necessary theoretical basis for the improvement and innovation of modern sensors and detection technology.
NMPC-based trajectory tracking control strategy for unmanned surface vehicle
Authors: Liu Zhiqiang , Xiang Qing , Ye Xi 
Published: July 2022

Abstract
To solve the unmanned surface vehicle trajectory tracking control problem under model uncertainty and external environmental disturbance, a trajectory tracking control strategy based on nonlinear model predictive control (NMPC) has been proposed. Firstly, a hydrodynamic model considering the uncertainty of model parameters and the influence of external environmental disturbance has been established; then, the fourth-order Lundgren-Kutta method has been used to discretize the nonlinear state space model, and the control quantity, control increment and output quantity of the system have been used as constraints to solve the optimization problem by numerical computation; finally, the reference circle has been used as the preset trajectory, and the trajectory tracking experiment has been carried out under the uncertainty of the model and external environmental disturbance. The experimental results show that the trajectory tracking strategy based on NMPC can better track the preset trajectory and has better anti-interference ability and control effect.
Control and Dynamic Simulation of Wire-Driven Precise Spray Robotic Arm
Authors: Niu Yuxin , Li Yishu , Bao Xiulan , Ma Xiaojie , Xu Kailun , Xu Jiadong , Chen Mingjun 
Published: July 2022

Abstract
The spraying of citrus to kill insects is a necessary part of the citrus planting process. Most of the currently used sprayers are cover sprays, which cannot achieve accurate and low-consumption spraying. Causing a lot of pesticide waste and environmental pollution. Aiming at the difficulty of precise spraying of citrus leaves, this paper proposes a soft spraying manipulator with good bending characteristics and flexible operation ability. The robotic arm consists of 6 joints and 2 arm segments. The two arm segments of the robotic arm are driven by two wire ropes and move in two orthogonal planes respectively. The PD controller design is designed. The joint state observers are constructed to predict joint angles, angular velocities, and other information. The dynamic simulation experiment is carried out, and the relationship between the wire rope tension and the spring elastic force changes with time, and the relationship between each joint angle changes with time. These make the wire-driven precise spray robotic arm potentially useful in agricultural spraying.
A New Ensemble Approach for Congestive Heart Failure and Arrhythmia Classification Using Shifted One-Dimensional Local Binary Patterns with Long Short-Term Memory
Authors: Çalışkan Abidin 
Published: July 2022

AbstractThe electrocardiogram (ECG) is a vital diagnostic tool for identifying a variety of cardiac disorders, including cardiac arrhythmia (ARR), sinus rhythms and heart failure. However, rapid interpretation of ECG recordings is quite important in the diagnosis of heart-related diseases. Many patients can be saved using the systems developed for the rapid and accurate analysis of ECG signals. A novel ensemble method based on shifted one-dimensional local binary patterns (S-1D-LBP) and long short-term memory (LSTM) is presented for the prognosis of ARR, normal sinus rhythm (NSR) and congestive heart failure (CHF) in this study. The ECG signals were first subjected to the S-1D-LBP method. Depending on the R and L parameters of this method, nine different signals are generated. Each of the histograms of these signals is given to LSTM models with the same hyperparameters. ECG signals are classified according to the common decisions of LSTM models with nine different input signals. The suggested method was tested using ECG signals (ARR, NSR and CHF) from the MIT-BIH and BIDMC datasets. Considering the results obtained in the applications carried out with various scenarios, it was observed that a high (99.6%) success rate was attained by the proposed approach. The suggested S-1D-LBP + ELSTM (Ensemble LSTM) model is expected to be safe to employ in the classification of various signals.
Hospital procedural volume and outcomes with catheter-directed intervention for pulmonary embolism: a nationwide analysis
Authors: Sedhom Ramy , Elbadawi Ayman , Megaly Michael , Jaber Wissam A , Cameron Scott J , Weinberg Ido , Mamas Mamas A , Elgendy Islam Y 
Published: July 2022

Abstract

Aims
There is limited data on the association between hospital catheter-directed intervention (CDI) volume and outcomes among patients with acute pulmonary embolism (PE).

Methods and results
The Nationwide Readmissions Database years 2016–2019 was utilized to identify hospitalizations undergoing CDI for acute PE. Hospitals were divided into tertiles based on annual CDI volume; low-volume (1–3 procedures), moderate-volume (4–12 procedures) and high-volume (&gt;12 procedures). The primary outcome was all-cause in-hospital mortality. Among 1 436 382 PE admissions, 2.6% underwent CDI; 5.6% were in low-volume, 17.3% in moderate-volume and 77.1% in high-volume hospitals. There was an inverse relationship between hospital CDI volume and in-hospital mortality (coefficient  −0.344, P &lt; 0.001). On multivariable regression analysis, hospitals with high CDI volume were associated with lower in-hospital mortality compared with hospitals with low CDI volume (adjusted odds ratio [OR] 0.71; 95% confidence interval [CI] 0.53, 0.95). Additionally, there was an inverse association between CDI volume and length of stay (LOS) (regression coefficient −0.023, 95% CI −0.027, −0.019) and cost (regression coefficient −74.6, 95% CI −98.8, −50.3). There were no differences in major bleeding and 30-day unplanned readmission rates between the three groups.

Conclusion
In this contemporary observational analysis of PE admissions undergoing CDI, there was an inverse association between hospital CDI volume and in-hospital mortality, LOS, and cost. Major bleeding and 30-day unplanned readmission rates were similar between the three groups.
On the effects of COVID-19 on food prices in India: a time-varying approach
Authors: Emediegwu Lotanna E , Nnadozie Obianuju O 
Published: July 2022

AbstractSince the inception of the novel coronavirus, immense research efforts have been made to understand how several economic indicators, including food security, would be affected. With India racing behind the United States in terms of daily infection rate and being a country with challenging food security issues, it is important to investigate how the presence of the pandemic has influenced the dynamics of food prices in the country. This paper considers seven price series from 167 markets across the five regions in India as well as the growth rate of COVID-19 infection. The paper uses a time-varying autoregressive model to investigate the nonlinear dynamics of food prices in relation to the pandemic in India. The resultant models reveal strong asymmetric properties with shock-inflicted persistence, which appear not to converge over the simulation period. Moreover, in terms of the location of the burden of the pandemic impact, we find a food product divide.
We can’t mitigate what we don’t monitor: using informatics to measure and improve healthcare systems’ climate impact and environmental footprint
Authors: Smith Carolynn L , Zurynski Yvonne , Braithwaite Jeffrey 
Published: July 2022

Abstract
Climate change, human health, and healthcare systems are inextricably linked. As the climate warms due to greenhouse gas (GHG) emissions, extreme weather events, such as floods, fires, and heatwaves, will drive up demand for healthcare. Delivering healthcare also contributes to climate change, accounting for ∼5% of the global carbon emissions. To rein in healthcare’s carbon footprint, clinicians and health policy makers must be able to measure the GHG contributions of healthcare systems and clinical practices. Herein, we scope potential informatics solutions to monitor the carbon footprint of healthcare systems and to support climate-change decision-making for clinicians, and healthcare policy makers. We discuss the importance of methods and tools that can link environmental, economic, and healthcare data, and outline challenges to the sustainability of monitoring efforts. A greater understanding of these connections will only be possible through further development and usage of models and tools that integrate diverse data sources.
Chemometric-Based AQbD and Green Chemistry Approaches to Chromatographic Analysis of Remogliflozin Etabonate and Vildagliptin
Authors: Prajapati Pintu , Ahir Hetal , Prajapati Bhumika , Shah Shailesh 
Published: July 2022

Abstract

Background
According to the green chemistry approach, during method development, the usage of toxic and carcinogenic organic solvents should be avoided or minimized for the safety of the environment and analysts. The chromatographic methods such as reverse-phase high-pressure liquid chromatography (RP-HPLC) and high-performance thin-layer chromatography (HPTLC) include the usage of class 2 organic solvents as per the International Council for Harmonization (ICH) Q3C (R6) guideline. The chromatographic analysis by HPTLC requires less organic solvent compared to the RP-HPLC method.

Objective
Hence, HPTLC-based chromatographic analysis of vildagliptin (VIL) and remogliflozin etabonate (RMG) has been carried out using green chemistry and analytical quality by design (AQbD) approaches.

Method
The principal component analysis (PCA)-based chemometric analysis was applied for the identification of critical method variables (CMV) for the development of the method. The design of experiments (DoE)-based Box-Behnken design (BBD) was applied for response surface modeling (RSM) and optimization of CMV. The analytical design space (ADS) and analytical control point were navigated for the development of the HPTLC method as per the quality target analytical profile.

Results
The chromatographic analysis of VIL and RMG was carried out using silica gel G60 F254 as the stationary phase and acetone–ethyl acetate–water–triethylamine (7.0 + 2.5 + 0.3 + 0.2, v/v) as the mobile phase. The HPTLC method was validated as per the ICH Q2 (R1) guideline. The HPTLC method was applied for the assay of fixed-dose combinations (FDCs) of VIL and RMG, and the results were found to comply with their labeled claim.

Conclusions
The developed method included the usage of organic solvents that belong to the class 3 category as per the ICH Q3C (R6) guideline. Hence, the developed method can be used as an eco-friendly alternative to published chromatographic methods for quality control and routine analysis of FDCs of VIL and RMG in the pharmaceutical industry.

Highlights
Chromatographic analysis of VIL and RMG using green chemistry and AQbD approaches. Application of the method for assay of drugs in their combined pharmaceutical dosage forms.
Judicial Discomfort over ‘Innovative’ Treatment for Adolescents with Gender Dysphoria
Authors: Taylor-Sands Michelle M , Dimopoulos Georgina 
Published: July 2022

Abstract
Medical treatment for adolescents with gender dysphoria has attracted considerable attention in recent years, with continuing court involvement in Australia and recent judicial review proceedings in the UK. In Re Imogen [No 6], the Family Court of Australia held that an application to the Family Court is mandatory if a parent or a medical practitioner of an adolescent diagnosed with gender dysphoria disputes the diagnosis, the adolescent’s capacity to consent, or the proposed treatment. In this article, we examine the Family Court’s rationale for preserving its welfare jurisdiction in gender dysphoria cases. We analyse case law developments in Australia and more recently in the UK and identify a thread of judicial discomfort in gender dysphoria jurisprudence about adolescents consenting to medical treatment that the court perceives to be ‘innovative’, ‘experimental’, ‘unique’, or ‘controversial’. We explore whether treatment for gender dysphoria can be characterised as ‘innovative’ and identify four factors that appear to be influencing courts in Australia and the UK. We also consider how such a characterisation might impact (if at all) on an adolescent’s capacity to consent to gender dysphoria treatment. We critique the ongoing role of courts in these cases and recommend a robust decision-making framework for gender dysphoria treatment to minimise court involvement in the future.
Army Health Systems Doctrine and Training in Relation to Antibiotics: A Systematic Review
Authors: Nichols Ryoma , Horstman Jordan , Nitz Iver 
Published: July 2022

ABSTRACT

Introduction
In the early 2000s when Tactical Combat Casualty Care was developed, the adoption of prophylactic antibiotic use was not mainstream. Back then, guidelines were derivative of civilian trauma guidelines which did not include widespread prophylactic antibiotic use. Current protocols across the DoD have embraced the use of prophylactic antibiotic use before reaching a military treatment facility as evidenced by Tactical Combat Casualty Care guidelines and several Joint Trauma System Clinical Practice Guidelines.
This review intends to find trends associated with the use of antibiotics in the military setting and answer the research question: Do current Army doctrine and practices address these issues and how can they be reworked to address them if needed?

Materials and Methods
Methods were developed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The primary author utilized four databases to locate articles: MEDLINE (EBSCOhost), Cochrane Central Register of Controlled Trials (Wiley), CINAHL Complete (EBSCOhost), and Embase (Elsevier). The following keywords were utilized: “Combat casualty,” “antibiotic,” “trauma,” and “prehospital.” This ultimately led to 19 articles included in the review.

Results
Nineteen articles were included in the final review and placed into one of the following categories: Overall antibiotic use, guideline adherence and practices, strains, and infection risk factors. Overall, the Army Health System has shown that there is room for improvement in terms of antibiotic stewardship and training regarding antibiotics.

Conclusion
Infectious diseases pose a substantial risk to combat wounded. The Army Health System must anticipate encountering challenges with delivering care to patients suffering infections in addition to serious combat injuries. A systematic review of the literature highlights several areas for improvement, primarily areas involving pathogen surveillance, treatment of pediatric populations, and the Army’s operational domain of training.
Safety and effectiveness of certolizumab pegol in Japanese patients with rheumatoid arthritis: Results from a 24-week post-marketing surveillance study
Authors: Kameda Hideto , Nishida Keiichiro , Nanki Toshihiro , Watanabe Akira , Oshima Yukiya , Momohara Shigeki 
Published: July 2022

ABSTRACTObjectivesTo report 24-week safety and effectiveness of certolizumab pegol (CZP) in Japanese patients with rheumatoid arthritis from a post-marketing surveillance study.MethodsEnrolled patients were newly receiving CZP. All adverse events (AEs) and adverse drug reactions (ADRs) were recorded for patients who received ≥1 CZP dose. Effectiveness outcomes included: 28-joint Disease Activity Score with erythrocyte sedimentation rate (DAS28-ESR) and European Alliance of Associations for Rheumatology (EULAR) response. Missing data were imputed using the last observation carried forward.Results3727 patients were enrolled; safety and effectiveness were evaluated in 3586 and 1794 patients, respectively. 24.9% of patients reported AEs (893/3586), 14.7% reported ADRs (528/3586), 8.3% (298/3586) reported serious AEs and 5.3% (190/3586) reported serious ADRs. Selected serious ADRs of interest: infections (110; 3.1%), tuberculosis (6; 0.2%), interstitial pneumonia (15; 0.4%), malignancy (8; 0.2%), and hepatic function disorder (7; 0.2%). No allergic reactions, autoimmune disease, cardiac failure, demyelinating diseases, or pancytopenia were reported. Mean DAS28-ESR reduced from 4.8 (baseline) to 3.4 (final evaluation). At final evaluation, 34.7% of patients achieved EULAR good response.ConclusionsThese real-world safety and effectiveness results were consistent with previously reported data, with no new safety signals identified. Long-term, real-world CZP safety and effectiveness data are needed.
Increased mtDNA mutation frequency in oocytes causes epigenetic alterations and embryonic defects
Authors: Han Longsen , Chen Yujia , Li Ling , Ren Chao , Wang Haichao , Wu Xinghan , Ge Juan , Shu Wenjie , Chen Minjian , Wang Qiang 
Published: July 2022

Abstract
Mitochondria are essential for female reproductive processes, yet the function of mitochondrial DNA (mtDNA) mutation in oocytes remains elusive. By employing an mtDNA mutator (Polgm) mouse model, we found the fetal growth retardation and placental dysfunction in post-implantation embryos derived from Polgm oocytes. Remarkably, Polgm oocytes displayed the global loss of DNA methylation; following fertilization, zygotic genome experienced insufficient demethylation, along with dysregulation of gene expression. Spindle–chromosome exchange experiment revealed that cytoplasmic factors in Polgm oocytes are responsible for such a deficient epigenetic remodeling. Moreover, metabolomic profiling identified a significant reduction in the α-ketoglutarate (αKG) level in oocytes from Polgm mice. Importantly, αKG supplement restored both DNA methylation state and transcriptional activity in Polgm embryos, consequently preventing the developmental defects. Our findings uncover the important role of oocyte mtDNA mutation in controlling epigenetic reprogramming and gene expression during embryogenesis. αKG deserves further evaluation as a potential drug for treating mitochondrial dysfunction-related fertility decline.
RNA editing of ion channels and receptors in physiology and neurological disorders
Authors: Zhai Jing , Koh Joanne Huifen , Soong Tuck Wah 
Published: July 2022

Abstract
Adenosine-to-inosine (A-to-I) RNA editing is a post-transcriptional modification that diversifies protein functions by recoding RNA or alters protein quantity by regulating mRNA level. A-to-I editing is catalyzed by adenosine deaminases that act on RNA. Millions of editing sites have been reported, but they are mostly found in non-coding sequences. However, there are also several recoding editing sites in transcripts coding for ion channels or transporters that have been shown to play important roles in physiology and changes in editing level are associated with neurological diseases. These editing sites are not only found to be evolutionary conserved across species, but they are also dynamically regulated spatially, developmentally and by environmental factors. In this review, we discuss the current knowledge of A-to-I RNA editing of ion channels and receptors in the context of their roles in physiology and pathological disease. We also discuss the regulation of editing events and site-directed RNA editing approaches for functional study that offer a therapeutic pathway for clinical applications.
KARRIKIN UPREGULATED F-BOX 1 negatively regulates drought tolerance in Arabidopsis
Authors: Tian Hongtao , Watanabe Yasuko , Nguyen Kien Huu , Tran Cuong Duy , Abdelrahman Mostafa , Liang Xiaohan , Xu Kun , Sepulveda Claudia , Mostofa Mohammad Golam , Van Ha Chien , Nelson David C , Mochida Keiichi , Tian Chunjie , Tanaka Maho , Seki Motoaki , Miao Yuchen , Tran Lam-Son Phan , Li Weiqiang 
Published: July 2022

Abstract
The karrikin (KAR) receptor and several related signaling components have been identified by forward genetic screening, but only a few studies have reported on upstream and downstream KAR signaling components and their roles in drought tolerance. Here, we characterized the functions of KAR UPREGULATED F-BOX 1 (KUF1) in drought tolerance using a reverse genetics approach in Arabidopsis (Arabidopsis thaliana). We observed that kuf1 mutant plants were more tolerant to drought stress than wild-type (WT) plants. To clarify the mechanisms by which KUF1 negatively regulates drought tolerance, we performed physiological, transcriptome, and morphological analyses. We found that kuf1 plants limited leaf water loss by reducing stomatal aperture and cuticular permeability. In addition, kuf1 plants showed increased sensitivity of stomatal closure, seed germination, primary root growth, and leaf senescence to abscisic acid (ABA). Genome-wide transcriptome comparisons of kuf1 and WT rosette leaves before and after dehydration showed that the differences in various drought tolerance-related traits were accompanied by differences in the expression of genes associated with stomatal closure (e.g. OPEN STOMATA 1), lipid and fatty acid metabolism (e.g. WAX ESTER SYNTHASE), and ABA responsiveness (e.g. ABA-RESPONSIVE ELEMENT 3). The kuf1 mutant plants had higher root/shoot ratios and root hair densities than WT plants, suggesting that they could absorb more water than WT plants. Together, these results demonstrate that KUF1 negatively regulates drought tolerance by modulating various physiological traits, morphological adjustments, and ABA responses and that the genetic manipulation of KUF1 in crops is a potential means of enhancing their drought tolerance.
Compliance in Non-Clinical Development of Cell-, Gene-, and Tissue-Based Medicines: Good Practice for Better Therapies
Authors: Lopez-Navas Luis , Torrents Sílvia , Sánchez-Pernaute Rosario , Vives Joaquim 
Published: July 2022

Abstract
The development of cell-, gene- and tissue engineering (CGT)-based therapies must adhere to strict pharmaceutical quality management standards, as for any other biological or small-molecule drug. However, early developments often failed to fully comply with good laboratory practices (GLP) in non-clinical safety studies. Despite an upward trend of positive opinions in marketing authorization applications, evidence of adherence to the principles of GLP is not openly reported; therefore, their relative impact on the overall quality of the product development program is unknown. Herein we investigated the actual degree of GLP implementation and the underlying factors impeding full compliance in non-clinical developments of CGT-based marketed medicines in the EU and USA, including (i) the co-existence of diverse quality management systems of more strategic value for small organizations, particularly current Good Manufacturing Practices n(GMP); (ii) lack of regulatory pressure to pursue GLP certification; and (iii) the involvement of public institutions lacking a pharmaceutical mindset and resources. As a final reflection, we propose conformity to good research practice criteria not as a doctrinaire impediment to scientific work, but as a facilitator of efficient clinical translation of more effective and safer innovative therapies.