bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphometric Analysis of Collagen in Different Grades of Oral Squamous Cell Carcinoma Using Picrosirius Red Stain and Spectrophotometry
Authors: Ashok Sahana , Ashok K. P. 
Published: December 2022

Introduction:
Oral squamous cell carcinoma (OSCC) is one of the most formidable health problems for mankind. These carcinomas are characterized by invasion of epithelial tumor cells into the stroma, which get embedded in extracellular matrix and collagen producing reactive changes. Such changes in the stroma may alter the biological aggressiveness of the tumor. An attempt was made to evaluate the collagen changes in different grades of OSCC which can contribute to understanding the biologic behavior of oral cancer and predict clinical outcomes.

Aims and Objectives:
To assess the quantitative changes in collagen in different grades of OSCC using hematoxylin and eosin (H and E) and Picrosirius red (PSR) stain through spectrophotometry and to compare the efficacy of these stains for estimation of collagen.

Materials and Methods:
The study comprised a total sample size of 60, which were distributed under 4 different groups, each containing 15 samples. Group I to IV consisted of normal buccal mucosa, with well-, moderately-, and poorly-differentiated OSCC, respectively. The tissues of 10 μm thickness were stained with H and E and PSR for spectrophotometric analysis.

Results:
The quantity of collagen decreased with increasing grades of OSCC. Comparison between two stains showed that PSR can provide a more reliable and accurate result than H and E.

Conclusion:
Collagen estimation is one of the methods to assess the progression of tumor. The method used in the present study for collagen estimation in different grades of OSCC is reliable and accurate.
Placental Dysfunction and Acute Toxoplasmosis: The Role of Melatonin in Relation to Inflammatory Cytokines Interleukin-10 and Interleukin-12
Authors: Al-Kuraishi Azhar H. , Khalil Hatham Ibraheem , Hassan Huda Hameed , Al-kuraishy Hayder M. 
Published: December 2022

Objective:
The objective of this study was to elucidate the potential role of anti-inflammatory interleukin (IL)-10 and pro-inflammatory (IL-12) cytokines as well as melatonin (MEL) in the development of placental dysfunction in the pregnant women with acquired toxoplasmosis (TOX).

Materials and Methods:
This case–control study was carried out at the Department of Clinical Parasitology in teamwork with the Department of Gynecology and Obstetrics, Al-Yarmouk Teaching Hospital, College of Medicine, Al-Mustansiriyah University, Baghdad, Iraq, from September 2018 to February 2019. The recruited patients and healthy controls were allocated into two groups – Group A: pregnant women with acute TOX (n = 45) and Group B: healthy pregnant women (n = 25). Anti-Toxoplasma (Toxo) immunoglobulin M (IgM), serum and placental as well as serum–placental (SP) ratio of MEL, IL-10, and IL-12 were measured. SPSS version 20.00 was used for data analysis.

Results:
Anti-Toxo IgM serum level and IL-12 serum levels were higher compared with controls (P = 0.001). Both MEL and IL-10 serum levels were lower in the pregnant women with acute TOX compared with controls (P = 0.002 and P = 0.002), respectively. Besides, Both MEL and IL-10 placental levels were lower in the pregnant women with acute TOX compared with controls (P = 0.001). As well, placental IL-12 level was higher in the pregnant women with acute TOX compared with controls (P = 0.001). SP ratio of MEL was higher in the pregnant women with acute TOX compared with controls (P = 0.001).

Conclusion:
MEL and anti-inflammatory IL-10 are reduced in the pregnant women with acute TOX, while IL-12 is increased. SP ratio of MEL but not of IL-10 or IL-12 is elevated in the pregnant women with acute TOX reflecting the risk of PD.
ImageJ-FIJI-Assisted Estimation of Intestinal Layers’ Volume: Study in Jejunum–Ileum of Rats
Authors: Wicaksono Satrio Adi , Sumiwi Yustina Andwi Ari , Paramita Dewi Kartikawati , Susilowati Rina 
Published: December 2022

Abstract

Background:
Studies in the digestive tract often required precision quantification of intestinal volume to observe the effect of certain intervention/condition. Application of stereological methods could bring unbiased and accurate results but commercially computer-assisted systems are not widely available. ImageJ-FIJI is an open source software, which could become an alternative choice in the stereological measurement process.

Aim:
This study describes simple stereological quantification methods during volume estimation of jejunum-ileum intestinal layers of the rats using a light microscope and ImageJ-FIJI stereological tool.

Material and Methods:
Six 3-months old male Sprague-Dawley rats were terminated and jejunum-ileum was harvested after perfusion. After removal of intestinal luminal content, whole jejunum-ileum weight was measured. The organ was sampled as 6-10 slabs of 1 cm length in a systematic uniformed random sampling manner. Slabs were cut longitudinally at random angles before flattened and put on filter papers for subsequent tissue processing into 2-3 paraffin blocks. One section of 3 μm thick was sampled from each block, stained using toluidine blue and documented using a light microscope connected to a microstepper apparatus. The volume of the intestinal layers was estimated using a point-counting grid on Image J-FIJI software.

Result:
We compared two sets of counting methods i.e. minimal counting (MC) and rigorous counting (RC) approaches that differ in their respective a/p value. Quantification using RC approach resulted in significantly higher estimated volume of tunica submucosa and tunica muscularis while having more preferable stereological accuracy parameters (CE<5% & CV<10%).

Conclusion:
Although it required longer counting time, rigorous approaches resulted in higher accuracy while still within the range of rule of thumb criteria of 0.2 < CE2/CV2 < 0.5.
Primary Sacral Activated B-Cell Like Diffuse Large B-Cell Lymphoma, Triple Expressor Type: A Case Report with Literature Review
Authors: Mohapatra Debahuti , Tripathy Pradipta , Mohanty Sandip , Pal Ankita 
Published: December 2022

Abstract
Primary bone lymphomas are unusual, and accounts for 2% among all lymphomas. Primary sacral lymphomas are still rarer with only 12 cases reported till date. They predominantly affect elderly males, showing occasional spinal epidural space involvement. We report a case of 49-year-old male complaining of low backache and radicular pain for 2 months, followed by the development of parasthesia and bladder and bowel involvement. Lumbosacral spine magnetic resonance imaging revealed an expansile lytic lesion of approximately 6.5 cm with enhanced soft-tissue component extending to neural foramina compressing the spinal cord. Biopsy showed non-Hodgkin’s lymphoma showing CD20, B-cell lymphoma (BCL) 6, BCL2, Multiple myeloma (MM) antigen 1 (MUM 1), and Cellular myelocytomatosis oncogene (C-Myc) positivity with CD10 negativity. Thus, the diagnosis of diffuse large B-cell lymphoma (DLBL)-activated B-cell type was rendered. Thirty cases of CD10-negative DLBL with Myc translocation in bone have been found which occur predominantly in Asians. Sacral primary DLBL with Myc translocation is extremely rare, only two cases are reported till date to the best of our knowledge. Because of its rarity, the prognosis and treatment of this entity are still not clear.
Pattern and Outcome of Heart Failure Amongst Children Admitted in an Emergency Pediatric Unit of a Tertiary Hospital in Sokoto State, North-Western Nigeria
Authors: Isezuo Khadijat O. , Sani Usman M. , Waziri Usman M. , Garba Bilkisu I. , Coker Lukman K. , Folorunsho Abdulrasheed 
Published: December 2022

Context:
Heart failure (HF) is a major cause of mortality in the emergency pediatric unit (EPU). It is the usual presentation of many structural cardiac and non cardiac diseases. An audit of the causes of heart failure is necessary to ensure adequate management and prevention.

Aim:
We describe the pattern and outcome of children with HF admitted to an EPU of a tertiary hospital in Sokoto.

Materials and Methods:
This was a cross-sectional study conducted in the EPU over 24 months (May 2019 to April 2021). Children aged 1 month to 15 years admitted with heart failure were recruited consecutively. The demographic characteristics, cause of heart failure, and outcome were entered into a proforma. Data were analyzed using IBM SPSS version 25.

Results:
One hundred and fifty-five out of 7158 children (2.2%) had HF. Majority of these 103 (66.5%) were aged 1 month to 5 years. The age range was 1–180 months with a mean of 55.4 (±53.7) months and a median of 36 (IQR: 86 months). Males accounted for 84 (54.2%) with a ratio of 1.18:1. The commonest causes of heart failure were congenital heart disease (CHD) 40: 25.8%; severe anemia 34: 21.9%; bronchopneumonia 30: 19.4%; rheumatic heart disease (RHD) 18: 11.6%; and dilated cardiomyopathy 16: 10.3%. There were 45(29.0%) deaths, of which CHD, RHD and severe anaemia accounted for the highest mortality.

Conclusion:
Structural heart diseases like CHD and RHD, in addition to severe anemia and bronchopneumonia, are significant causes of heart failure and mortality in this environment. A holistic approach to prevention is necessary to reduce the burden.
A Single-Center Detection of Adult Patients with Advanced Periodontal Disease Using Surgical Assessment and Cone-Beam Computed Tomography
Authors: Chandran Ajay , Das Maneesha , Gufran Khalid , Khan Mohammad Shoyab , Alqahtani Abdullah Saad , Chikkanna Meenakumari , Swarnalatha C , Babu J Suresh , Nayyar Abhishek Singh 
Published: December 2022

Context:
One of the major limitations of conventional radiological procedures is the presence of considerable overlapping and lack of clear, three-dimensional information. Cone-beam computed tomography (CBCT) has emerged as an effective imaging modality in such situations offering high-quality images and lower radiation exposure to patients.

Aim:
The aim of the present study was to assess the role of CBCT in the detection of intra-bony defects in patients with advanced periodontal disease.

Settings and Design:
The present study was designed as a prospective, observational study wherein patients aged between 35–55 years with advanced periodontal disease who were indicated for periodontal treatment in form of periodontal surgeries were selected from the outpatient department (OPD) based on defined inclusion and exclusion criteria.

Materials and Methods:
Sixty patients with chronic periodontitis with 12 teeth each including 6 anterior and 6 posterior teeth were selected for making measurements pre- and peri-operatively while bone defects were measured first with the help of CBCT software installed in an individualized system devised to be used for storing and analyzing CBCT images and then, during surgical intervention using standardized UNC-15 periodontal probe and compared.

Statistical Analysis Used:
Statistical analysis was performed using SPSS version 18.0 (SPSS Inc., Chicago, IL, USA). The measurements obtained with the help of CBCT software installed in the personalized system and those obtained on surgical exploration were compared in each anterior and posterior tooth with the help of paired-sample t-test while Pearson's correlation(r) was used to test the correlation between the observed values. The level of statistical significance was set at P < 0.05.

Results:
The results were found to be highly significant both in terms of statistical (P-value) and clinical (r) significance for various sites in the anterior and posterior teeth in all instances.

Conclusions:
From the observations made from the present study, it could be concluded that CBCT provided highly precise assessment of bone topography equivalent to the judgment obtained during surgical exposure at the sites of interest preoperatively, which helped in assessing the exact type and depth of defect present and helped in optimizing surgical treatment planning.
Using a Rat Model to Translate and Explore the Pathogenesis of Ketamine-Induced Cystitis
Authors: Huang Ying-Che , Lee Wei-Chia , Chuang Yao-Chi , Tsai Cheng-Nan , Yu Chun-Chieh , Wang Hung-Jen , Su Chia-Hao 
Published: December 2022

Purpose:
Ketamine abusers may develop severe ulcerative cystitis along with irritative bladder symptoms. A reliable animal model may benefit the understanding of pathophysiologies and the development of therapeutic strategies for ketamine-induced cystitis (KIC). We used a popular rat model of KIC to validate the micturition behavior, functional brain images, and possible molecular mechanisms of this model.

Materials and Methods:
Female Sprague–Dawley rats were distributed to control (saline) and ketamine-treated rats (25 mg/kg/day for 28 days). Functional magnetic resonance imaging (fMRI), metabolic cage study, and cystometry were evaluated. Potential bladder transcripts involved in KIC were screened by using next-generation sequencing.

Results:
In contrast to the control, the ketamine-treated rats developed bladder overactivity accompanied by enhanced fMRI signals in periaqueduct and caudal putamen areas. Alterations in bladder transcripts, including eleven genes involving in regulating NF-κB signaling of bladder inflammation, and Crhr2 gene overexpression associating with vascular endothelial growth factor signaling of bladder ischemia were found in ketamine-treated rats. Both categories could be attributed to neurogenic inflammation induced by the direct toxicity of urinary ketamine and its metabolites.

Conclusion:
Our study results suggest this animal model could mimic irritative bladder symptoms associated with central sensitization in KIC. Through the bladder transcripts analysis, we highlight the neurogenic inflammation underlying the pathophysiologies of KIC in rats.
The Effect of Intraurethrally Applied Anatolian Propolis Extract on Urethral Healing in a Rat Model
Authors: Girgin Reha , Can Emine Yilmaz , Çeker Gökhan , Kaymaz Esin , Çinar önder , Mungan Necmettin Aydin 
Published: December 2022

Purpose:
Urethral stricture may cause irreversible results, as it prevents normal voiding. Although various endoscopic and open surgical options are available, the results are not always satisfactory so the main purpose is to prevent the formation of urethral scar. Our purpose was to examine the effects of intraurethrally administered Anatolian propolis on healing after an experimental urethral injury.

Materials and Methods:
A total of 40 Wistar male rats were used. Rats were divided into five equal groups: healthy control (Group 1), urethral damage/pathology (Group 2), solvent control (Group 3), 1-week propolis treatment (Group 4) and 3-week propolis treatment (Group 5). Urethral damage was performed with a 29G needle. Intraurethral, 50% ethanol, was administered in the solvent control group and 30% propolis was administered intraurethrally to the rats in Groups 3 and 4. Penile tissues were taken under deep anesthesia and examined under a light microscope.

Results:
Irregularities and luminal narrowing in the urethral epithelium and connective tissue were found in Group 2, except for one rat. Similarly, hyperemia-bleeding was observed in all rats except for one rat. Irregularities and hyperemia in the urethral epithelium and connective tissue were found in Group 3, except for two rats. Total improvement was observed in one rat, and more than 50% of fibrosis was observed in four rats in Groups 2 and 3. In Group 4, irregularity was observed in the urethral epithelium in four rats, while no inflammation was found in five rats. All of the rats had <50% fibrosis. In Group 5, six rats had complete recovery and <30% fibrosis.

Conclusion:
Anatolian propolis applied into the urethra seems to accelerate recovery after urethral trauma and reduces the formation of fibrosis.
An atlas of K3 surfaces with finite automorphism group
Authors: Roulleau Xavier 
Published: December 2022

We study the geometry of the K3 surfaces $X$ with a finite number automorphisms and Picard number $\geq 3$. We describe these surfaces classified by Nikulin and Vinberg as double covers of simpler surfaces or embedded in a projective space. We study moreover the configurations of their finite set of $(-2)$-curves.Comment: 95 pages, 80 figures, 1 Table
Проблемні аспекти банківського контролю під час воєнного стану
Authors: Склярова Злата 
Published: December 2022

З початком повномасштабної війни в Україні економіка держави зазнала сильного удару та деякою мірою була виведена і стану рівноваги, оскільки повністю підготуватись до найгіршого сценарію було неможливо. Постала гостра потреба змінити звичний алгоритм дій та підготувати фінансову систему до тривалих воєнних дій на території України. Аби втримати контроль над економікою, призупинити процес інфляції та не поглибити економічну кризу до катастрофічного стану, органами державної влади, Національним банком України, Міністерство фінансів тощо було проведено ряд необхідних заходів. У даній роботі було виокремлено та освітлено зміни саме у системі банківського контролю. У даній статті розглянуто поняття банківського контролю, його ключові аспекти. Перелічено основні напрямки банківського контролю у мирний час та під час воєнного стану в Україні. Розглянуто процес виконання Банком своєї основної функції. Перелічено головні ризики у фінансовій сфері та можливість їх справдження. Вказано інфляційні очікування на кінець 2022 року. Зазначено та досліджено основні дії Національного банку України на початку війни, їх мету та результати. Виявлено головні проблеми економіки України в період війни, її слабкі сторони. Проведено паралель із діями Національного банку під час кризи, яка була спричинена коронавірусом у 2020 році. Вказано майбутні можливі кроки задля покращення стану економіки та перспективи подальшого розвитку. Перелічено напрямки, у яких буде рухатись Україна після завершення війни.
Estudio sobre el síndrome de Sjögren.
Authors: Llamuca Cali Gisela Mercedes , Naranjo Ruiz Luis Fernando , Reyes Pérez María Augusta 
Published: December 2022

La investigación tiene como objetivo conocer el síndrome de Sjögren como una afección infrecuente, mediante una revisión bibliográfica. Para realizar la presente investigación, su principal finalidad es proponer una definición clara, precisa y concisa acerca del síndrome de Sjögren. Hubo varios estudios que han encontrado el procedimiento de las mutaciones del síndrome de Sjögren, y varios estudios expresan que ha ido evolucionando, y con ello, disminuyendo el riesgo de complicaciones y recidivas. Se concluyó que el síndrome de Sjögren se basa principalmente en datos clínicos y analíticos, y se puede llegar a diagnosticar en los primeros momentos del nacimiento según las manifestaciones observadas en el caso que se estudie.
SERANGAN PENYAKIT KUNANG-KUNANG DI PANTI BENIH UDANG VANAME (Litopenaeus vannamei)
Authors: Panjaitan Pohan , Syafitri Emmy 
Published: December 2022

Penyakit kunang-kunang terjadi di panti benih udang vanamei daerah Kecamatan Pantai Cermin, Kabupaten Serdang Bedagai Propinsi Sumatra Utara. Penyakit kunang-kunang termasuk sebagai penyakit yang cukup ganas sehingga penelitian ini sangat essensial dilakukan untuk mengidentifikasi penyenab serangan penyakit kunang-kunang di panti benih udang. Penelitian ini bertujuan untuk memperoleh informasi tentang serangan penyakit kunang-kunang di panti benih melalui pemeriksaan bakteriologik secars kuantitas dari bakteri penghasil cahaya di media pemeliharaan dan pada tubuh larva udang serta pengukuran parameter fisika dan kimia air media pemeliharaan larva udang. Penelitian ini dilakukan selama dua bulan yaitu Juni sampai Juli 2022 di panti benih udang PT.Windu Pertiwi Pantai Cermin Kiri, Kecamatan Pantai Cermin, Kabupaten Serdang Bedagai dan di laboratorium Fakultas Peternakan Universitas HKBP Nomensen Medan Sumatra Utara. Larva udang yang digunakan dalam penelitian ini adalah pasca larva udang vannamei (Litopenaeus vannamei) yang mengalami serangan penyakit kunang-kunang dan larva yang tidak mengalami serangan penyakit kunang-kunang (sebagai pembanding), stadia larva udang yang diamati berkiasar antara pasca larva 5 dan 6. Model analisis yang digunakan dalam penelitian ini adalah model regresi berganda dan pengolahan data memakai mikrostat dengan metode stepwise. Bakteri penghasil cahaya ditemukan di air media pemeliharaan dan pada larva udang di panti benih udang yang terserang penyakit kunangg-kunang. Sebaliknya tidak ditemukan di air media pemeliharaan dan pada tubuh larva udang yang tidak terserang penyakit kunang-kunang. Dengan demikian bakteri penghasil cahaya diduga penyebab serangan penyakit kunang-kunang di bak pemeliharaan larva yang terserang penyakit kunang-kungang di panti benih udang tersebt. Jumlah bakteri penghasil caya di air media pemeliharaan dan di tubuh larva udang dipengaruhi olek konsentrasi bahan organik dalam air media pemeliharaan larva udang
Os limites da emancipação: regulação da terra e luta por moradia
Authors: Ana Luiza Vieira Gonçalves  
Published: December 2022

O presente artigo busca discutir os limites do potencial emancipatório da luta por moradia, a partir da identificação dos diferentes atores das formas gestão e agenciamento de territórios e populações marginalizadas da cidade de São Paulo, entrelaçando agentes que disputam o protagonismo da ação política e de controle nos territórios de ocupações na zona sul da cidade, com a análise centrada na ocupação Anchieta - campo da pesquisa de mestrado a qual o artigo se relaciona -, localizada no Grajaú, Zona Sul, relacionando-se a outras ocupações da região. O eixo central é a análise de como as estratégias de financiamento, regulação e intervenção física do Estado e da população no ambiente construído, assim como as formas de organização e institucionalização das políticas públicas e das formas de organização social se entrelaçam com a produção e reprodução do espaço urbano e regional, a partir das novas modulações do neoliberalismo no Brasil.
Pengaruh Uang Elektronik dan Surat Berharga Syariah Negara (SBSN) terhadap Jumlah Uang Beredar di Indonesia
Authors: Ulmi Nur Halisa , Devi Abrista 
Published: December 2022

As the central bank of the Republic of Indonesia, Bank Indonesia has three main responsibilities: creating and implementing monetary policy, regulating and maintaining a seamless payment system, including cash and non-cash payments, and financial system stabilization. To achieve this goals, Bank Indonesia can use one of the sharia monetary instruments, specifically Government Islamic Securities and it is authorized to provide efficient payment instruments such as non-cash electronic money payment instruments, the development of which may have an effect on the money supply. The goal of this study was to determine the effect of electronic money and Government Islamic Securities on Indonesia's money supply. The data used in this analysis is secondary data in the form of a time series of 84 observations that includes monthly data on electronic money, Government Islamic Securities and the money supply from Bank Indonesia publications for the period January 2015 to December 2021. Using the EViews 10 program, this study technique employs the restricted VAR (Vector Autoregression)/VECM (Vector Error Correction Model) analysis method. The results of this study reveal that the variable of electronic money in the short term does not significantly affect the money supply. Electronic money, on the other hand, has a long-term positive influence on the money supply. The variable of Government Islamic Securities in the short term does not significantly affect the money supply. Meanwhile, Government Islamic Securities have a negative impact on the money supply in the long term.
Keywords: Electronic Money, Government Islamic Securities and Money Supply.