bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness analysis of durvalumab as a maintenance treatment for patients with locally advanced, unresectable, stage Ⅲ nsclc in china
Authors: Jiang Xiaotong , Chen Jinyu , Zheng Min , Jia Hanxue 
Published: June 2022

Objective
The aim of this study was to evaluate the cost-effectiveness of durvalumab compared with Best supportive care (BSC) after chemoradiotherapy in patients with stage III non-small cell lung cancer from healthcare system perspective in China.

Methods
A dynamic state transition model was adopted to simulate life time, direct medical costs and QALYs. In the base case scenario, for patients with unresectable, stage Ⅲ non-small cell lung cancer whose disease has not progressed after platinum-based chemoradiation therapy, the treatment group would use durvalumab whereas the control group would use BSC. Clinical data and health utility were derived from the patient-level data of Asian ethnicity in the PACIFIC trial. Cost of drug acquisition, follow-up, medical service, inspection, terminal care and adverse event treatment were considered in this model. The cost of durvalumab was calculated based on retail prices and Patient Assistance Program.

Results
In the base case, the durvalumab group yielded an additional 2.60 LYs and 2.37QALYs (discounted), causing an additional cost of 0.459 million RMB and 0.109 million RMB without and with PAP, so the ICER was 193,898 RMB/QALY and 46,093.12 RMB/QALY respectively.

Conclusions
This study demonstrated that durvalumab can improve the survival of patients with unresectable, stage Ⅲ non-small cell lung cancer whose disease has not progressed after platinum-based chemoradiation therapy and would be a cost-effective option compared with BSC at a willingness to pay (WTP) threshold of 212676 RMB (three times GDP per capita of China in 2019).
Promoting healthy lifestyles among nurse trainees: Perceptions on enablers and barriers to dietary and physical activity behaviours
Authors: Doegah Phidelia Theresa , Acquah Evelyn 
Published: June 2022

Introduction
Promoting healthy lifestyles is important to protect against obesity and non-communicable diseases. However, there is a lack of understanding of the enablers and barriers to healthy lifestyles (dietary and physical activity) among pre-service nursing trainees in Ghana. This study therefore aims to examine the perceived practice, enablers and barriers in adopting healthy dietary and physical activity behaviours.

Materials and methods
Cross-sectional qualitative, one-on-one in-depth interviews with a semi-structured guide were conducted with 16 nursing trainees (public health nursing) (aged: 18–25 years) in the School of Nursing and Midwifery, University of Health and Allied Sciences. Participants were selected based on body mass index (underweight, normal, over-weight, and obesity) classification of the world health organization. The interviews were audio-recorded and transcribed. Data analysis was manually carried out.

Results
Enablers and barriers were grouped into levels of individual (intrapersonal), social environment, physical environment, and university factors based on ecological model initially formulated by Bronfenbrenner’s. Enablers to healthy dietary behaviour were self-discipline, dietary knowledge, social support, and access/availability. Enablers related to physical activity mentioned were body image, social support, and the existence of student societies. Barriers to healthy dietary behaviour included upbringing, preference, accessibility, safety/appearance, and studies/lectures. Barriers mentioned in relation to physical activity include a busy lifestyle, inadequate feeding, studies/academic activity, student societies, upbringing, and social support.

Conclusion
A program to support healthy lifestyles for nursing trainees is needed. Specifically, in terms of developing and implementing interventions to overcome barriers and promote facilitators to adopt healthy dietary and physical activity behaviours whilst in training.
Metastatic Anal Squamous Cell Carcinoma Presenting as an Indeterminate Biliary Stricture Diagnosed By Cholangioscopy
Authors: Nahar Ritu , Holmes Ian , Baliff Jeffrey , Chiang Austin , Kowalski Thomas 
Published: June 2022

ABSTRACT
Anal squamous cell carcinoma (SCC) rarely metastasizes outside the pelvis. Although liver involvement has been described, biliary strictures from metastatic disease are exceedingly rare. We report a case of a patient with metastatic anal SCC presenting as a biliary stricture, which was identified on endoscopic retrograde cholangiopancreatography with single-operator cholangioscopy. Direct visualization of the stricture with single-operator cholangioscopy may prove critical in obtaining a timely diagnosis. Therapeutic options for metastatic anal SCC are limited, but chemotherapy can be considered, and surgical resection is an option for limited disease.
Recalcitrant Gastric Actinomycosis Treated With Over-the-Scope Clip
Authors: McDonald Nicholas M. , Luz Leticia P. , Amin Khalid , Amateau Stuart K. 
Published: June 2022

ABSTRACT
Actinomycosis is an infrequent infection caused by Actinomyces species bacteria. Gastric actinomycosis is extremely rare but has been identified on endoscopy, typically presenting as erythema or ulceration. Standard therapies include prolonged antibiotics, and when these fail, gastric actinomycosis often requires surgical resection. We present a case of recalcitrant gastric actinomycosis, which presented as a subepithelial lesion and the first demonstration of treatment with endoscopic resection through over-the-scope clip.
Carnitine Deficiency in an Adult With Short Bowel Syndrome After Surgical Resection
Authors: Kamel Amir Y. , Ruiz Nicole C. , Murray Melissa R. , Gayle Ansley M. , Pham Angela , Beduschi Thiago , Rosenthal Martin D. 
Published: June 2022

ABSTRACT
Carnitine is an essential cofactor for fatty acid metabolism. Deficiencies can be associated with muscle weakness, fatigue, weight loss, and cardiomyopathies. A 27-year-old woman with short bowel syndrome (SBS) presented with significant weight loss, fatigue, and muscle wasting despite adequate parenteral nutrition. Her laboratory test results revealed carnitine deficiency secondary to malnutrition. Levocarnitine supplementation was initiated with normalization of her carnitine levels. Her fatigue improved, and her weight returned to baseline. Carnitine deficiencies are seldomly reported in adults, particularly those with SBS. Carnitine deficiency should be suspected and corrected in patients with SBS and malabsorptive capacity due to surgical resection.
Faktor Resiliensi pada Tunanetra Laki-laki Dewasa: Scooping review
Authors: Kusumaningrum Ervia , Dewi Nur Setiawati , Andriany Megah 
Published: June 2022

Introduction: The prevalence of visually impaired in Indonesia has increased significantly every year. The visually impaired condition is often used by unscrupulous persons to become victims of criminal acts because of their powerlessness. Blind people need resilience to survive in the conditions experienced. There have been many studies on resilience in the blind in general, but none has specifically reviewed the visually impaired adult male. This study aims to reviewed resilience factors of visually impaired adult male.Methods: The researcher used the scoping review method to get a clear picture of resilience factors of the blind adult male. Literature search was carried out using search keywords visually impaired, resilience factors, adult male blind. The database used is Scopus, PUBMED and Google Scholar. Articles inclusion criteria are articles reviewed of publication in the last 10 years (2010-2020), full and specific text are available with research question about the resilience of male blind adult.Result: Based on the identification, there were 166 articles from search engines Scopus, PUBMED and Google Scholar. There were six articles that match the criteria after going through the selection process. Resilience has many factors such as the environment, family and individual. The researcher used the PEO question format (population, exposure, outcome) to find related research articles.Conclusion: Blind people have more serious challenges in building resilience, so further studies need to be done to make interventions to help build resilience for male blind adults.
Heavy Metals (Hg, Cd, Pb, Cu) in Greenback Mullets (Planiliza subviridis Valenciennes, 1836) from Bojonegara coastal waters, Banten Bay, Indonesia
Authors: Afiyatillah Ghinarrahmi , Sulistiono Sulistiono , Hariyadi Sigid , Simanjuntak Charles PH , Riani Etty , Rostika Rita , Kleinertz Sonja 
Published: June 2022

Waste from industrial activities can be a source of pollution for the waters of Banten Bay. One source of these pollutants are heavy metals. High concentrations of heavy metals in waters can pollute the aquatic environment, endangering all organisms. Heavy metals can accumulate in aquatic environments and living organisms such as fish. The greenback mullet Planiliza subviridis (Valenciennes, 1836) is known as a fish for human consumption. Heavy metals that are contained in mullets can move to a higher trophic level within the food chain and endanger the health of humans. This study aims to analyze the accumulation of heavy metals, such as Hg, Cd, Pb, and Cu, in the flesh of greenback mullets at Bojonegara Waters of Banten Bay. The research was carried out for five months (August - October 2020 and March - April 2021). Samplings were taken from Terate River and Wadas River, which are mullet fishing areas and natural habitats of these mullets. Data analysis consisted of descriptive and quantitative analyses. The results showed that the Hg, Cd, Pb, and Cu contents were below the quality standards based on Government Regulation of the Republic of Indonesia (PP RI) No. 22 of 2021. The greenback mullets have experienced a moderate accumulation rate. The different rates of Cu metal accumulation in each month indicate a variation in catches with low to moderate accumulation rates. The water conditions in Bojonegara can still be seen as tolerable and still suitable for mullets usable for human consumption in a reasonable amount. Monitoring and evaluation activities need to be carried out periodically for the management of the aquatic environment in Bojonegara.
Determinan Keberlanjutan Petani Sawit Swadaya dalam Rantai Pasok Multi-Jenjang
Authors: Nashr Fakhrizal , Putri Eka Intan Kumala , Dharmawan Arya Hadi , Akhmad Fauzi 
Published: June 2022

Studi ini melihat determinan keberlanjutan petani sawit swadaya menurut pengaruh dan ketergantungannya pada tiga tipologi wilayah Kabupaten Kutai Kartanegara. Variabel kesesuaian lahan yang memiliki posisi paling penting terhadap sistem keberlanjutan. Determinan penyerapan tenaga kerja, peluang usaha lain dan akses finansial merupakan variabel terdampak. Sementara itu, determinan teknologi informasi dan sosial media serta hasil produksi sawit menunjukan variabel dengan sensitivitas tinggi dan sangat tidak stabil dalam rantai pasok perkebunan kelapa sawit swadaya. Intervensi apapun pada variabel-variabel yang disebut terakhir tidak akan stabil bagi pembangunan kelapa sawit serta akan memberikan dampak terhadap keseluruhan sistem keberlanjutan petani sawit swadaya. Hasil analisis MICMAC menjadi titik tolak faktor-faktor yang menentukan sistem rantai pasok petani sawit swadaya berada pada keberlanjutan atau sebaliknya di Kabupaten Kutai Kartanegara. Hasil merekomendasikan faktor kesesuaian lahan sebagai determinan strategis di tingkat kabupaten untuk mencapai rantai pasok yang kredibel bagi keberlanjutan dari tingkat lokal hingga nasional.
Positive rate‐dependent action potential prolongation by modulating potassium ion channels
Authors: Cabo Candido 
Published: June 2022

AbstractPharmacological agents that prolong action potential duration (APD) to a larger extent at slow rates than at the fast excitation rates typical of ventricular tachycardia exhibit reverse rate dependence. Reverse rate dependence has been linked to the lack of efficacy of class III agents at preventing arrhythmias because the doses required to have an antiarrhythmic effect at fast rates may have pro‐arrhythmic effects at slow rates due to an excessive APD prolongation. In this report, we show that, in computer models of the ventricular action potential, APD prolongation by accelerating phase 2 repolarization (by increasing IKs) and decelerating phase 3 repolarization (by blocking IKr and IK1) results in a robust positive rate dependence (i.e., larger APD prolongation at fast rates than at slow rates). In contrast, APD prolongation by blocking a specific potassium channel type results in reverse rate dependence or a moderate positive rate dependence. Interventions that result in a strong positive rate dependence tend to decrease the repolarization reserve because they require substantial IK1 block. However, limiting IK1 block to ~50% results in a strong positive rate dependence with moderate decrease in repolarization reserve. In conclusion, the use of a combination of IKs activators and IKr and IK1 blockers could result in APD prolongation that potentially maximizes antiarrhythmic effects (by maximizing APD prolongation at fast excitation rates) and minimizes pro‐arrhythmic effects (by minimizing APD prolongation at slow excitation rates).
Optimization type of filler on electrochemical and thermal properties of gel polymer electrolytes membranes for safety lithium-ion batteries
Authors: Dyartanti Endah R. , Purwanto Agus , Jumari Arif , Paramitha Tika 
Published: June 2022

Abstract
Gel polymer electrolyte (GPE) membranes of polyvinylidene fluoride-based polymer matrix of different filler types such as nano-clay, ZnO, and SiO2 extracted from fly ash is produced using the non-solvent induced phase separation method. Moreover, the electrochemical properties, electrode compatibility, and the batteries performance are investigated using these gel electrolyte membranes. It is observed that gel electrolytes with nano-clay filler exhibited more stable ionic conductivity and charge–discharge performance than those containing ZnO and SiO2 extracted from fly ash. A maximum ionic conductivity of 5.62 × 10–3 S cm−1 was obtained with the addition of 8 wt% nano-clay filler at room temperature. The LiFePO4 performance assembled with these membranes is examined using coin cells (LiFePO4/GPE/graphite). After 50 cycles with a rate of 0.2 C, the battery with a different filler retained 97.7% of its initial capacity. It should be noted that this type of filler influences the electrolyte absorption, electrochemical properties, and performance of the LiFePO4.
Improved sequential autotuning of PI controllers for industrial-scale polymerization (ISP) reactor
Authors: Maniraman Priyadharsini , Dharmalingam Kalpana , Manickam Chidambaram 
Published: June 2022

Abstract
This current work proposes a refined investigation on the improved sequential relay autotuning method to compute the optimal parameters of the decentralized PI controller for Two Input Two Output (TITO) system using relay feedback method. The sustained oscillation occurring in the relay response with the sequential relay autotuning and the simultaneous relay autotuning method is analyzed by taking the higher-order harmonics into consideration and the efficient performance results of the decentralized PI control systems are obtained. These methods have been applied to an Industrial-Scale Polymerization (ISP) reactor transfer function model. In closed-loop studies, comparative analysis of autotuning methods has been carried out using simulation. The effect of measurement noise and robustness are studied in the proposed work. The robustness performance of the system using improved sequential relay autotuning is enhanced by 5–25% for servo operation and 11–40% for regulatory operation. The performance of the systems with the effect of measurement noise using improved sequential relay autotuning is enhanced by 2–24% for servo operation. Comparative analysis has been carried out with the improved sequential relay autotuning and the simultaneous relay autotuning method. It is observed that the proposed method provides improved closed-loop performances and less sum of Integral square error even in presence of robustness and effect of measurement noise.
Solutions to problems about potentially K

s,t
-bigraphic pair
Authors: Yin Jian-Hua , Zhang Liang 
Published: June 2022

Abstract
Let

S
=

(

a

1

,

…

,

a

m

;

b

1

,

…

,

b

n

)

S=\left({a}_{1},\ldots ,{a}_{m};\hspace{0.33em}{b}_{1},\ldots ,{b}_{n})

, where

a

1

,

…

,

a

m

{a}_{1},\ldots ,{a}_{m}

and

b

1

,

…

,

b

n

{b}_{1},\ldots ,{b}_{n}

are two nonincreasing sequences of nonnegative integers. The pair

S
=

(

a

1

,

…

,

a

m

;

b

1

,

…

,

b

n

)

S=\left({a}_{1},\ldots ,{a}_{m};\hspace{0.33em}{b}_{1},\ldots ,{b}_{n})

is said to be a bigraphic pair if there is a simple bipartite graph

G
=

(

X
∪
Y
,
E

)

G=\left(X\cup Y,E)

such that

a

1

,

…

,

a

m

{a}_{1},\ldots ,{a}_{m}

and

b

1

,

…

,

b

n

{b}_{1},\ldots ,{b}_{n}

are the degrees of the vertices in

X

X

and

Y

Y

, respectively. In this case,

G

G

is referred to as a realization of

S

S

. Given a bigraphic pair

S

S

, and a complete bipartite graph

K

s
,
t

{K}_{s,t}

, we say that

S

S

is a potentially

K

s
,
t

{K}_{s,t}

-bigraphic pair if some realization of

S

S

contains

K

s
,
t

{K}_{s,t}

as a subgraph (with

s

s

vertices in the part of size

m

m

and

t

t

in the part of size

n

n

). Ferrara et al. (Potentially H-bigraphic sequences, Discuss. Math. Graph Theory 29 (2009), 583–596) defined

σ

(

K

s
,
t

,
m
,
n

)

\sigma \left({K}_{s,t},m,n)

to be the minimum integer

k

k

such that every bigraphic pair

S
=

(

a

1

,

…

,

a

m

;

b

1

,

…

,

b

n

)

S=\left({a}_{1},\ldots ,{a}_{m};{b}_{1},\ldots ,{b}_{n})

with

σ

(

S

)

=

a

1

+
⋯
+

a

m

≥
k

\sigma \left(S)={a}_{1}+\cdots +{a}_{m}\ge k

is a potentially

K

s
,
t

{K}_{s,t}

-bigraphic pair. This problem can be viewed as a “potential” degree sequence relaxation of the (forcible) Turán problem. Ferrara et al. determined

σ

(

K

s
,
t

,
m
,
n

)

\sigma \left({K}_{s,t},m,n)

for

n
≥
m
≥
9

s

4

t

4

n\ge m\ge 9{s}^{4}{t}^{4}

. In this paper, we further determine

σ

(

K

s
,
t

,
m
,
n

)

\sigma \left({K}_{s,t},m,n)

for

n
≥
m
≥
s

n\ge m\ge s

and

n
+
m
≥
2

t

2

+
t
+
s

n+m\ge 2{t}^{2}+t+s

. As two corollaries, if

n
≥
m
≥

t

2

+

t
+
s

2

n\ge m\ge {t}^{2}+\frac{t+s}{2}

or if

n
≥
m
≥
s

n\ge m\ge s

and

n
≥
2

t

2

+
t

n\ge 2{t}^{2}+t

, the values

σ

(

K

s
,
t

,
m
,
n

)

\sigma \left({K}_{s,t},m,n)

are determined completely. These results give a solution to a problem due to Ferrara et al. and a solution to a problem due to Yin and Wang.
PENGARUH FAKTOR KESIHATAN MENTAL, KECERDASAN SPIRITUAL KE ATAS KEBAHAGIAAN HIDUP DAN PRESTASI AKADEMIK PELAJAR
Authors: Mat Wajar Muhammad Salehan Alhafiz , Hamzah Rohana Binti , Mohamad Ahmad Muhaimin , Christina Andin  
Published: June 2022

Abstract - This paper presents an insight on the effect of mental health and spiritual intelligence on the happiness and academic performance among undergraduate students at Universiti Malaysia Pahang (UMP). The study had been conducted using quantitative method. A set of questionnaire had been distributed to 460 respondents randomly and selected from a population of 9121 UMP undergraduate students. In prior, the instrument had been checked for its validity and reliability. Results indicate majority of the respondents had achieved high level of mental health, spiritual intelligence and happiness. The correlation analysis revealed that mental health and spiritual intelligence had a significant positive effect on happiness and academic performance. The regression analysis however had shown that happiness had no significant mediation effect on the relationship between mental health and spiritual intelligence and academic performance. Overall, this study had filled in the literature gap on the level of mental health, spiritual intelligence and happiness among students in the context of Malaysian universities particularly in UMP. The model developed by the researcher can be used as a reference in future studies for further investigate how students’ happiness and academic performance can be enhanced through their mental health and spiritual intelligence.

Abstrak - Penyelidikan ini bertujuan untuk mengkaji pengaruh faktor kesihatan mental dan kecerdasan spiritual ke atas kebahagiaan hidup dan prestasi akademik pelajar-pelajar Ijazah Sarjana Muda di Universiti Malaysia Pahang (UMP). Kajian dijalankan secara kuantitatif melalui kaedah tinjauan dengan menggunakan soal selidik sebagai instrumen kajian ke atas 460 orang responden yang dipilih secara rawak mudah daripada 9121 orang pelajar Ijazah Sarjana Muda UMP. Analisis deskriptif mendapati majoriti responden mempunyai tahap kesihatan mental, kecerdasan spiritual dan kebahagiaan hidup yang agak tinggi. Analisis korelasi pula menunjukkan bahawa kesihatan mental dan kecerdasan spiritual berhubung secara positif dengan kebahagiaan hidup dan prestasi akademik. Analisis regresi walau bagaimanapun membuktikan bahawa kebahagiaan hidup tidak mempunyai pengaruh mediasi yang signifikan ke atas hubungan di antara kesihatan mental dan kecerdasan spiritual dengan prestasi akademik. Secara keseluruhannya, kajian ini telah menyumbang kepada kekurangan dalam literatur mengenai tahap kesihatan mental, kecerdasan spiritual dan kebahagiaan hidup dalam konteks pelajar universiti di Malaysia khususnya di UMP. Model yang dibina dalam kajian ini boleh dijadikan rujukan kajian yang lebih mendalam pada masa akan datang untuk memahami bagaimana kebahagiaan hidup dan prestasi akademik pelajar boleh ditingkatkan melalui kesihatan mental dan kekuatan kerohanian mereka.
Efficient Stochastic Optimization for Low-Rank Distance Metric Learning
Authors: Zhang Jie , Zhang Lijun 
Published: June 2022

Although distance metric learning has been successfully applied to many real-world applications, learning a distance metric from large-scale and high-dimensional data remains a challenging problem. Due to the PSD constraint, the computational complexity of previous algorithms per iteration is at least O(d2) where d is the dimensionality of the data.In this paper, we develop an efficient stochastic algorithm for a class of distance metric learning problems with nuclear norm regularization, referred to as low-rank DML. By utilizing the low-rank structure of the intermediate solutions and stochastic gradients, the complexity of our algorithm has a linear dependence on the dimensionality d. The key idea is to maintain all the iterates in factorized representations and construct stochastic gradients that are low-rank. In this way, the projection onto the PSD cone can be implemented efficiently by incremental SVD. Experimental results on several data sets validate the effectiveness and efficiency of our method.
Sparse Boltzmann Machines with Structure Learning as Applied to Text Analysis
Authors: Chen Zhourong , Zhang Nevin , Yeung Dit-Yan , Chen Peixian 
Published: June 2022

We are interested in exploring the possibility and benefits of structure learning for deep models. As the first step, this paper investigates the matter for Restricted Boltzmann Machines (RBMs). We conduct the study with Replicated Softmax, a variant of RBMs for unsupervised text analysis. We present a method for learning what we call Sparse Boltzmann Machines, where each hidden unit is connected to a subset of the visible units instead of all of them. Empirical results show that the method yields models with significantly improved model fit and interpretability as compared with RBMs where each hidden unit is connected to all visible units.