bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of CYP2C19 polymorphisms on antidepressant prescription patterns and treatment emergent mania in bipolar disorder
Authors: Joas Erik , Jonsson Lina , Viktorin Alexander , Smedler Erik , Pålsson Erik , Goodwin Guy M. , Landén Mikael 
Published: November 2022

AbstractAntidepressant medication is used extensively to treat bipolar depression despite uncertain efficacy. The cytochrome P450 (CYP) 2C19 enzyme metabolize several antidepressants, and polymorphisms in the corresponding gene CYP2C19 influence plasma concentration and hence treatment outcomes in major depressive disorder. Here, we investigate if CYP2C19 polymorphisms are associated with antidepressant treatment patterns and the risk of mania when antidepressants are used in bipolar disorder. Two single nucleotide polymorphisms (rs4244285 and rs12248560) were used to classify 5019 bipolar disorder patients into CYP2C19 metabolic phenotypes ranging from poor to ultra-rapid metabolizers. We used Swedish national registry data 2005–2017 on dispensed medications and inpatient care to estimate risks for early-treatment persistence, treatment discontinuation, switching to a new antidepressant medication, and mania within 3 months of treatment initiation in patients treated with citalopram, escitalopram, sertraline, amitriptyline, and clomipramine. Metabolic phenotypes of CYP2C19 were not robustly associated with the investigated treatment outcomes based on dispense patterns. Slower metabolism was associated with an increased risk of treatment emergent mania for sertraline (hazard ratio [HR] = 1.3, 95% CI = 1.04–1.62, p = 0.02) and the tricyclic antidepressants amitriptyline and clomipramine (HR = 1.46, 95% CI = 1.05–2.02, p = 0.024). In a large study of the impact of CYP2C19 metabolic phenotypes on antidepressant treatment of bipolar depression, we found an association between slower CYP2C19 metabolism and higher risk of treatment emergent mania, which is a step towards personalized risk assessments. There were, however, no clear associations with early treatment persistence, treatment discontinuation, and switching to a new antidepressant.
Co-transplantation of pancreatic islets and microvascular fragments effectively restores normoglycemia in diabetic mice
Authors: Wrublewsky Selina , Weinzierl Andrea , Hornung Isabelle , Prates-Roma Leticia , Menger Michael D. , Laschke Matthias W. , Ampofo Emmanuel 
Published: November 2022

AbstractInsufficient revascularization of pancreatic islets is one of the major obstacles impairing the success of islet transplantation. To overcome this problem, we introduce in the present study a straightforward strategy to accelerate the engraftment of isolated islets. For this purpose, we co-transplanted 250 islets and 20,000 adipose tissue-derived microvascular fragments (MVF) from donor mice under the kidney capsule as well as 500 or 1000 islets with 40,000 MVF into the subcutaneous space of diabetic mice. We found that the co-transplantation of islets and MVF markedly accelerates the restoration of normoglycemia in diabetic recipients compared with the transplantation of islets alone. In fact, the transplantation of 250 islets with 20,000 MVF under the kidney capsule reversed diabetes in 88% of mice and the subcutaneous transplantation of 500 or 1000 islets with 40,000 MVF restored normoglycemia in 100% of mice. Moreover, diabetic mice receiving islets and MVF exhibited plasma insulin levels similar to nondiabetic control animals. Additional immunohistochemical analyses of the grafts revealed a significantly higher number of islet cells and microvessels in the co-transplantation groups. These findings demonstrate that the co-transplantation of islets and MVF is a promising strategy to improve the success rates of islet transplantation, which could be easily implemented into future clinical practice.
Clinical associations and prognostic implications of 6-minute walk test in rheumatoid arthritis
Authors: Ferreira Maria Betânia , Saraiva Francisca A. , Fonseca Tomás , Costa Rita , Marinho António , Oliveira José Carlos , Carvalho Henrique Cyrne , Rodrigues Patrícia , Ferreira João Pedro 
Published: November 2022

AbstractThe clinical associations and prognostic implications of the 6-minute walk test (6MWT) distance in patients with rheumatoid arthritis (RA) is yet to be explored. To identify the clinical features and prognostic implications associated with the 6MWT in patients with RA. Cohort study including 387 RA patients who underwent 6MWT. Regression models (linear and logistic) were built to identify independent predictors of shorter 6MWT distance. Cox proportional models were used to study the association of 6MWT distance with cardiovascular outcomes. Patients were subdivided according to 6MWT tertiles: 126 patients walked > 405 m, 129 walked 345-405 m, and 132 walked < 345 m. Older age (> 55 years), elevated waist circumference, NT-pro BNP > 125 pg/mL, anemia, C-reactive protein ≥ 3 mg/dL, and troponin T ≥ 14 pg/mL were independent predictors of walking shorter distances. Patients walking less than 345 m had higher risk of a subsequent cardiovascular hospitalization or cardiovascular death compared with patients walking 345 m or more (adjusted HR: 2.98, 95%CI: 1.37–6.51, p = 0.006). Older age, abdominal obesity, anemia, cardiac dysfunction, and inflammation were associated with walking shorter distances in patients with RA. Walking less than 345 m in the 6MWT was associated with a poor cardiovascular prognosis. The 6MWT is simple, reproducible, and inexpensive, easily performed in routine practice, and provides important information regarding the patients´ status and outcomes, enabling the monitorization of the therapeutic optimization of the various domains of the RA.
Circulating tumor cells as a prognostic biomarker in patients with hepatocellular carcinoma
Authors: Prasoppokakorn Thaninee , Buntho Areeya , Ingrungruanglert Praewphan , Tiyarattanachai Thodsawit , Jaihan Tassanan , Kulkraisri Kittipat , Ariyaskul Darlene , Phathong Chonlada , Israsena Nipan , Rerknimitr Rungsun , Treeprasertsuk Sombat , Chaiteerakij Roongruedee 
Published: November 2022

AbstractCirculating tumor cells (CTCs) have been shown as a surrogate for cancer progression and prognostication. We aimed to determine an association between CTCs and survival of hepatocellular carcinoma (HCC) patients. Peripheral blood was obtained from 73 HCC patients to enumerate for epithelial CTCs/8 mL blood. CTCs were detected by immunoaffinity-based method using epithelial cell adhesion molecule (EpCAM) and mucin1 (MUC1). The CTCs detection rates of BCLC stages A, B, and C patients were 65.4% (17/26), 77.3% (17/22), and 96% (24/25), respectively, p = 0.018. Patients with CTCs < 5 cells/8 mL had significantly longer survival than those with CTCs ≥ 5 cells/8 mL (>36 vs. 4.6 months, p < 0.001). In multivariate analysis, CTP B, BCLC B, BCLC C, AFP ≥ 400 ng/mL, and CTC ≥ 5 cells/8 mL were independently associated with survival, with adjusted HRs (95%CI) of 4.1 (2.0–8.4), 3.5 (1.1–11.4), 4.7 (1.4–15.4), 2.4 (1.1–5.0), and 2.6 (1.2–8.4); p < 0.001, 0.036, 0.011, 0.025 and 0.012, respectively. The combination of CTCs ≥ 5 cells/8 mL and AFP ≥ 400 ng/mL provided additively increased HR to 5.3 (2.5–11.1), compared to HRs of 4.0 (2.0–8.0) and 3.5 (1.8–6.7) for CTCs ≥ 5 cells/8 mL and AFP ≥ 400 ng/mL, p < 0.001, respectively. The larger number of peripheral CTCs is correlated with higher tumor aggressive features and poorer survival of HCC patients. CTCs can potentially become novel prognostic biomarker in HCC.
Synthesis of magnetic nanocarbon using palm oil as the green precursor via microwave-assisted arc for wastewater treatment
Authors: Zakaria Nurul Zariah Jakaria , Rozali Shaifulazuar , Mubarak Nabisab Mujawar , Khalid Mohammad 
Published: November 2022

AbstractThe presence of metal with microwave irradiation has always invited controversial arguments as the metal will catch on fire easily. But interestingly, researchers found that arc discharge phenomena provide a promising way for molecule cracking to synthesize nanomaterials. This study developed a single-step yet affordable synthesis approach that combines microwave heating and arcing in transforming crude palm oil into magnetic nanocarbon (MNC), which can be considered a new alternative for the palm oil sectors. It involves synthesizing the medium at a partial inert condition with constant coiled stainless steel metal wire (dielectric media) and ferrocene (catalyst). This approach successfully demonstrates heating at a temperature ranging from 190.9 to 472.0 °C with different synthesis times (10–20 min). The produced MNC shows formations of spheres with average sizes of 20.38–31.04 nm, mesoporous structure (SBET: 14.83–151.95 m2/g), and high content of fixed carbon (52.79–71.24wt%), and the ratio of the D and G bands (ID/IG) is 0.98–0.99. The formation of new peaks in the FTIR spectra (522.29–588.48 cm−1) supports the appearance of the FeO compounds from the ferrocene. The magnetometer shows high magnetization saturation (22.32–26.84 emu/g) in ferromagnetic materials. The application of the MNC in wastewater treatment has been demonstrated by evaluating their adsorbent capability with Methylene Blue (MB) adsorption test at a different concentrations varying between 5 and 20 ppm. The MNC produced at synthesis time (20 min) shows the highest adsorption efficiency (10.36 mg/g) compared to others, with 87.79% removal of MB dye. As a result, the value for Langmuir is not promising compared to Freundlich, withR2being around 0.80, 0.98, and 0.99 for MNC synthesized at 10 min (MNC10), 15 min (MNC15), and 20 min (MNC20), respectively. Hence, the adsorption system is in a heterogeneous condition. The microwave-assisted arcing thereby presents a promising approach to transforming CPO into MNC that could remove the hazardous dye.
Comparison of artificial intelligence algorithms and their ranking for the prediction of genetic merit in sheep
Authors: Hamadani Ambreen , Ganai Nazir A. , Mudasir Syed , Shanaz Syed , Alam Safeer , Hussain Ishraq 
Published: November 2022

AbstractAs the amount of data on farms grows, it is important to evaluate the potential of artificial intelligence for making farming predictions. Considering all this, this study was undertaken to evaluate various machine learning (ML) algorithms using 52-year data for sheep. Data preparation was done before analysis. Breeding values were estimated using Best Linear Unbiased Prediction. 12 ML algorithms were evaluated for their ability to predict the breeding values. The variance inflation factor for all features selected through principal component analysis (PCA) was 1. The correlation coefficients between true and predicted values for artificial neural networks, Bayesian ridge regression, classification and regression trees, gradient boosting algorithm, K nearest neighbours, multivariate adaptive regression splines (MARS) algorithm, polynomial regression, principal component regression (PCR), random forests, support vector machines, XGBoost algorithm were 0.852, 0.742, 0.869, 0.915, 0.781, 0.746, 0.742, 0.746, 0.917, 0.777, 0.915 respectively for breeding value prediction. Random forests had the highest correlation coefficients. Among the prediction equations generated using OLS, the highest coefficient of determination was 0.569. A total of 12 machine learning models were developed from the prediction of breeding values in sheep in the present study. It may be said that machine learning techniques can perform predictions with reasonable accuracies and can thus be viable alternatives to conventional strategies for breeding value prediction.
Evaluation of the antibacterial activities of face masks coated with titanium dioxide nanoparticles
Authors: Ahmed Omar B. , Alamro Turki 
Published: November 2022

AbstractTo control infectious diseases, various applications of nanotechnology have been used to enhance the self-cleaning and antibacterial properties of materials.This study aimed to evaluate the antibacterial properties of face masks coated with TiO2 nanoparticles.The antibacterial efficacies of cloth face masks coated with TiO2 were measured by inoculating them in bacterial suspensions (105CFUs from bothE. coliandS. aureus). The results showed that TiO2 nanoparticle solutions (at 2%) reduced the starting inoculum of 105CFUs (5 log cfu/cm2) ofE. coliandS. aureusto 1.3 and 1.68 log, respectively, with antibacterial activities of 3.7 and 3.34 log, respectively. Furthermore, at a 1% concentration, the antibacterial activities againstE. coliandS. aureuswere 2.1 and 2.01 log, respectively, while at a low concentration (0.5%), the antibacterial activities againstE. coliandS. aureuswere 1.8 and 1.72 log, respectively. The CFUs in all the experimental groups were significantly lower than those in the control group (saline). In conclusion, TiO2 nanoparticle solutions with a high concentration (2%) demonstrated a strong antibacterial effect onE. coliandS. aureus, and the difference was statistically significant, while a significant antibacterial activity was demonstrated with lower concentration (0.5% and 1%) nanoparticle solutions of TiO2 after 18 h. There was a statistically significant difference regarding colony reduction betweenE. coliandS. aureuseven at 3 h. The antibacterial activities of TiO2 in face masks could be promising for reducing the risk of bacterial infections.
Promotion of Communication Access, Choice, and Agency for Autistic Students
Authors: Donaldson Amy L. , corbin endever* , Zisk Alyssa Hillary , Eddy Brandon 
Published: November 2022

Purpose:
Families and professionals often consider augmentative and alternative communication (AAC) a “last resort” for persons with communication challenges; however, speaking autistic adults have reported that they would have benefited from access to AAC as children. This tutorial discusses the history of this “last resort” practice and its perpetuation within the medical model of disability. The tutorial focuses on communication access, choice, and agency for autistic students.

Method:
We provide a brief overview of the AAC community and their preferred terminology, review the history of traditional approaches to research on AAC and autism, and then examine the relationship between disability models and ableism to views of spoken language as a priority of intervention. Studies on this topic are rare, and resisting ableism requires acknowledging and honoring disabled people's experiences and expertise. Therefore, we promote autistic expertise within the framework of evidence-based practice and discuss the experiences of autistic people and spoken language. Finally, we consider the role of the speech-language pathologist (SLP) in assessment and offer autistic-based strategies and recommendations for communication support.

Conclusions:
Speaking autistic students who could benefit from AAC may not have access to AAC due to the prioritization of spoken language and lack of awareness of the benefit of AAC. We recommend that SLPs and school-based professionals support and facilitate access, communicative choice, and agency by implementing multimodal communication strategies to include AAC use for autistic students regardless of their spoken language status. Promoting all types of communication and ensuring opportunities for communication across multiple modalities are paramount to a child's agency and self-determination, as is normalization of AAC.
Social Validity, Cost, Acceptability, and Feasibility of Augmentative and Alternative Communication Devices Used for Individuals With Autism Spectrum Disorder and Intellectual Disability: A Systematic Review
Authors: Pierson Lauren M. , Ganz Jay B. , Pustejovsky James E. , Reichle Joe , Vannest Kimberly J. , Wattanawongwan Sanikan , Foster Margaret , Fuller Marcus C. , Haas April N. , Sallese Mary Rose , Smith S. D. , Yllades Valeria , Kenny Emily , Morgan Peyton , Paterson Scout 
Published: November 2022

Purpose:
The authors conducted a systematic review of single-case experimental designs that included individuals with autism spectrum disorder and/or intellectual disability who used speech-generating devices (SGDs) for communication. The purpose of this study was to review subjective and normative pre- and post-intervention social validity data, in addition to the cost, acceptability, and feasibility of the SGDs used in the studies. The authors also studied trends in the reporting of pre- and post-intervention data over time.

Method:
A systematic review of 7,327 articles resulted in 86 articles that met design quality criteria and included participants who used SGDs. A group of raters completed interrater reliability for all stages of the review.

Results:
Researchers reported more subjective than normative data. Few studies reported on the price of the SGD or the person who purchased the SGD. More researchers reported using an SGD with more than one use, but few solicited feedback about the SGD used during the intervention. Few researchers reported information about the portability of the device or the operation effort.

Conclusions:
Reporting on social validity represents a substantial limitation in experimental studies. Future work incorporating less biased/more objective measures is important for the creation of socially valid interventions.
Precise dynamical masses of new directly imaged companions from combining relative astrometry, radial velocities, and HIPPARCOS-Gaia eDR3 accelerations
Authors: Rickman E. L. , Matthews E. , Ceva W. , Ségransan D. , Brandt G. M. , Zhang H. , Brandt T. D. , Forveille T. , Hagelberg J. , Udry S. 
Published: November 2022

Aims. With an observing time span of more than 20 yr, the CORALIE radial-velocity survey is able to detect long-term trends in data corresponding to companions with masses and separations accessible to direct imaging. Combining exoplanet detection techniques, such as radial velocities from the CORALIE survey, astrometric accelerations from HIPPARCOS and Gaia eDR3, and relative astrometry from direct imaging, removes the degeneracy of unknown orbital parameters. This allows precise model-independent masses of detected companions to be derived, which provides a powerful tool to test models of stellar and substellar mass-luminosity relations.
Methods. Long-term precise Doppler measurements with the CORALIE spectrograph reveal radial-velocity signatures of companions on long-period orbits. The long baseline of radial-velocity data allows the detectability of the companion candidates to be assessed with direct imaging. We combine long-period radial-velocity data with absolute astrometry from HIPPARCOS and Gaia eDR3 and relative astrometry derived from new direct imaging detections with VLT/SPHERE to fit orbital parameters and derive precise dynamical masses of these companions.
Results. In this paper we report the discovery of new companions orbiting HD 142234, HD 143616, and HIP 22059, as well as the first direct detection of HD 92987 B, and update the dynamical masses of two previously directly imaged companions: HD 157338 B and HD 195010 B. The companions span a period range of 32–279 yr and are all very low-mass stellar companions, ranging from 218 to 487 MJup. We compare the derived dynamical masses to mass-luminosity relations of very low-mass stars (<0.5 M⊙), and discuss the importance of using precursor radial-velocity and astrometric information to inform the future of high-contrast imaging of exoplanets and brown dwarfs.
Effect of Impeller Size on the Performance of a Single Blade Pump
Authors: Knížat Branislav , Šlachtič Dušan , Olšiak Róbert 
Published: November 2022

Changing the impeller diameter is a frequently used method for adjusting pump performance parameters. In the case of conventional multi-blade impellers, this is done by reducing the diameter on the machine tool to the prescribed shape. The other dimensions of the pump (diffuser, inlet) remain unchanged. This method is called trimming. The article deals with the diameter reduction and subsequent modification of the performance parameters of a single blade pump. These pumps are characterized by certain specific features. First of all, it is an unsymmetrical impeller that must be both statically and dynamically balanced. This plays an essential role in the whole modification process. Research results obtained on a pump with an impeller diameter of 138 mm are presented. The change in diameter was monitored on a total of 3 impellers. Experiments were carried out in the laboratory of hydraulic machinery. The results were verified by CFD calculations.
Research background: The article concerns the modification of impellers of single blade pumps. The effects of diameter modifications on multi-blade pumps are currently known. However, these have symmetrical impellers and can therefore be changed without restriction. For asymmetric (single blade) impellers, the problem is more complex as additional mass must be added to provide static and dynamic balance.
Purpose of the article: The aim is to determine the nature of the change in performance parameters when the output diameter is changed. The results of the research can be applied in the prediction of the change in the operating point and the creation of tombstone charts.
Methods: Two kinds of methods were used in the research: experiment and CFD calculation. A total of 4 impeller sizes were investigated.
Findings & Value added: The results of the paper can be divided into two areas. In the experimental area, a device was designed to measure the characteristics of single blade pumps. Four impellers were manufactured and tested. In the area of CFD calculations, simulations of the hydraulic parameters around the best efficiency point (BEP) were performed. The calculation results were verified by experiment. The nature of the change of the BEP when the diameter of the impeller changes up to 87.9 % was found.
Analysis of the Efficiency of the Experimental Design of an OFF-GRID Photovoltaic System for Local Purposes of Electricity Generation
Authors: Šmajda Michal , Polivka Nikolas , Shmyhol Dmytro 
Published: November 2022

Research background: Increasingly the implementation of vehicles with alternative propulsion such as battery or hydrogen vehicles there are higher demands on electricity production. The main factor affecting the environment such vehicles is mainly a source of electricity, which recharges the batteries of vehicles or hydrogen produced as fuel for fuel cells.
Purpose of the article: Presented analysis examines the effectiveness of the experimental design of a local OFF-GRID photovoltaic system intended to support of alternative automotive drives.
Methods: As a basis for determining the efficiency of the proposed device is the analysis of a run-in photovoltaic system is used installed in the same geographical conditions with data validation with database PV-GIS.
Findings and added value: From the analysis of the investigated design of the photovoltaic system shows that electricity production during the year it is directly dependent on the intensity of global radiation. The proposed solution makes it possible to partially cover the energy requirements in transport with active use RES.
Perioperative Anaphylaxie – alte Zöpfe und Neues zu den Auslösern
Authors: Bayerl Christiane 
Published: November 2022

ZusammenfassungPerioperative Anaphylaxien werden mit mindestens 1:6000 angegeben. Neue Kenntnisse der Pathophysiologie der anaphylaktischen Reaktionen beziehen die Auslösung über das Mastzell-related G-Protein und die Komplementaktivierungs-abhängige Pseudoallergie mit ein. Neu beschriebene Auslöser sind das Chlorhexidin oder Gelatine-Produkte, eingesetzt zur Blutstillung oder blaue Farbstoffe zur intraoperativen Markierung. Wachsamkeit ist in Hinblick auf biphasische Reaktionen geboten. Propofol darf mittlerweile bei Ei- und Sojaallergikern eingesetzt werden.