bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges of coronavirus disease 2019 (COVID-19) in Lebanon in the midst of the economic collapse
Authors: Zahreddine Nada K. , Haddad Sara F. , Kerbage Anthony , Kanj Souha S. 
Published: April 2022

AbstractLebanon, one of the smallest countries in the Middle East, has held for decades a reputation for being the premier medical hub for patients from the Arab world as well as neighboring countries and for offering world-class treatment and advanced medical services. However, this once world-renowned healthcare sector is now facing a risk of imminent collapse as overlapping crises have struck the country since October 2019. In this article, we describe the concomitant political, economic, and financial challenges that Lebanon is facing, which have strained the national healthcare system and have undermined its ability to respond to the coronavirus disease 2019 (COVID-19) pandemic. We present an overview of the political instability, the Lebanese revolution with countrywide protests, as well as the devaluation of the Lebanese currency representing one of the worst economic meltdowns since the 19th century. We describe the unprecedented energy crisis the country is facing and the disastrous consequences of the Beirut port explosion of August 2020. We review the efforts and measures taken by different stakeholders to contain the COVID-19 pandemic amid the multifaceted challenges and the large exodus of healthcare personnel.
Why the long teeth? Morphometric analysis suggests different selective pressures on functional occlusal traits in Plio-Pleistocene African suids
Authors: Yang Deming , Pisano Asli , Kolasa Joan , Jashashvili Tea , Kibii Job , Gomez Cano Ana R. , Viriot Laurent , Grine Frederick E. , Souron Antoine 
Published: April 2022

AbstractNeogene and Pleistocene African suids displayed convergent evolutionary trends in the third molar (M3) morphology, with increasingly elongated and higher crowns through time. While these features can prevent premature loss of masticatory functionality and potentially increase long-term reproductive success, changes in dental occlusal traits such as enamel complexity and thickness can also improve chewing efficiency and increase short-term energetic return. While both long-term and short-term benefits can contribute to the thriving of a lineage, the selective pressures associated with each category can be different. To examine how crown elongation correlates with these functional occlusal traits, we selected M3s ofKolpochoerus,Notochoerus, andMetridiochoerusfrom Kenya and South Africa, dated between 3.0 Ma and 0.4 Ma. To account for dental wear, we used micro-computed tomography imaging of unworn/slightly worn M3s to simulate wear progression within each tooth. We compared morphometric representatives of occlusal enamel complexity and thickness among the specimens following their respective wear trajectories. We found that M3 elongation correlates with higher occlusal complexity and thinner enamel inNotochoerusandMetridiochoeruslineages through time. InKolpochoerus, enamel complexity and thickness were generally maintained through time, despite M3 elongation. The differences in M3 morphometric trends suggest thatKolpochoeruslikely experienced a different set of selective pressures on functional occlusal traits compared withNotochoerusandMetridiochoerus. The shared evolutionary trends of M3 specialization amongNotochoerusandMetridiochoerussuggest similar selective pressures on their chewing efficiency and the possibility of a dietary niche overlap in more xeric habitats.
Advancing head and neck cancer following the coronavirus disease 2019 pandemic
Authors: Flynn W , Maqsood R , Maseland T , Montgomery J , Douglas C 
Published: April 2022

AbstractObjectiveDelay in the diagnosis of head and neck cancer can result in significant excess morbidity and mortality. How the pandemic has affected patient presentation in Scotland is unknown.MethodThis retrospective cohort study compared all presentations of head and neck cancer between June and October of 2019 with the same period following the peak of the pandemic in 2020 in West Scotland, a region populated by 2.5 million people.ResultsA total of 528 patients met our inclusion criteria. Compared with 2019, patients in 2020 were more likely to present with a higher American Joint Committee on Cancer stage (odds ratio, 1.67 (95 per cent confidence interval = 1.20 to 2.31); p = 0.002), a longer preceding symptom duration (odds ratio, 2.03 (95 per cent confidence interval = 1.44 to 2.87; p < 0.001) and to have an emergency presentation (odds ratio, 2.53, (95 per cent confidence interval = 1.15 to 5.55; p = 0.017).ConclusionPatients are presenting later with more advanced head and neck cancer following the coronavirus disease 2019 pandemic.
Population growth ofGyrodactylus kobayashiiin goldfish (Carassius auratus) associated with host density
Authors: Jin Xiao , Zou Hong , Li Ming , Wu Shangong , Wang Guitang , Marcogliese David J. , Li Wenxiang 
Published: April 2022

AbstractHost density is a key regulatory factor in parasite transmission. The goldfish (Carassius auratus)-Gyrodactylus kobayashiimodel was used to investigate effects of host density on population growth of gyrodactylids. A donor fish infected by five gravid gyrodactylids was mixed with 11 parasite-free goldfish at five host densities. There was a significant positive correlation between host density and mean abundance ofG. kobayashiithroughout the 58-day experiment. During early infection (days 15–24), mean abundance in medium high (0.5 fish L−1) and high host density groups (1 and 2 fish L−1) was significantly higher than that in the low host density groups (0.125 and 0.25 fish L−1). At high host density, prevalence increased more rapidly, and the peak prevalence was higher. Fitting of an exponential growth model showed that the population growth rate of the parasite increased with host density. A hypothesis was proposed that higher host density contributed to increased reinfection of detached gyrodactylids. A reinfection experiment was designed to test this hypothesis. Both mean abundance and prevalence at a host density of 1 fish L−1were significantly higher than those at 0.25 fish L−1on days 1 and 3, which suggested that more reinfections ofG. kobyashiioccurred at the higher host density. Density-dependent transmission during the early infection was an important contributor of population growth ofG. kobayashii, as well as density-dependent reinfection of the detached gyrodactylids.
Foreign Occupation and Support for International Cooperation
Authors: Aaskoven Lasse 
Published: April 2022

AbstractA growing literature investigates how historical state repression affects later political outcomes, but little attention has been given to whether violence during foreign occupation affects support for international cooperation. This article investigates this issue by analyzing the 1972 Danish referendum on membership in the European Economic Community (eec)—an organization seen at the time as being dominated by Germany. The analysis shows that municipalities that experienced more German-inflicted violence during the German occupation of Denmark (1940–1945) in World War II had a higher rate of no votes in this referendum. This effect seems to have worked through increased support for Danish far-left parties that were associated with the Danish resistance movement and that actively used anti-German sentiment in their campaigns against eec membership. The results suggest that foreign-inflicted violence can be a substantial hindrance for popular support for international cooperation and that political parties play an important role in translating historical grievances into mass political behavior.
Evaluation of the Early Childhood Music Education project’s influence on the development of 3- to 5-year-old children in Andalusia, Spain
Authors: Thapa Joseph , Rodríguez-Quiles José A. 
Published: April 2022

AbstractIn 2005, the Barenboim-Said Foundation launched the Early Childhood Music Education project in Andalusia (Spain) to promote music education for young children. Ten years later, an initial study was performed to evaluate the influence of the project on the development of the participating children. The results of this study form part of a broader ongoing research project, in collaboration with the University of Seville, aimed at investigating the influence of the Early Childhood Music Education project on general aspects of child development. This study has a quasi-experimental design, framed in Gardner’s Theory of Multiple Intelligences, consisting of an experimental and a control group (n = 1101) and the administration of a questionnaire, adapted to measure and compare means between the two groups, as the sole measurement tool. The results, analysed using an independent samples t-test for the comparison of means and Cohen’s d effect size, reveal statistically significant differences in the means of the dimensions of the experimental and control groups. This confirms the hypothesis that the Early Childhood Music Education project has a positive impact on the different dimensions, in accordance with Gardner’s Theory of Multiple Intelligences.
Defining the role of the hypothalamic-pituitary-adrenal axis in the relationship between fetal growth and adult cardiometabolic outcomes
Authors: Martin Wrivu N. , Wang Carol A. , Lye Stephen J. , Reynolds Rebecca M. , Matthews Stephen G. , McLaughlin Carly E. , Oldmeadow Christopher , Mori Trevor A. , Beilin Lawrence , Smith Roger , Pennell Craig E. 
Published: April 2022

AbstractAnimal and human data demonstrate independent relationships between fetal growth, hypothalamic-pituitary-adrenal axis function (HPA-A) and adult cardiometabolic outcomes. While the association between fetal growth and adult cardiometabolic outcomes is well-established, the role of the HPA-A in these relationships is unclear. This study aims to determine whether HPA-A function mediates or moderates this relationship. Approximately 2900 pregnant women were recruited between 1989-1991 in the Raine Study. Detailed anthropometric data was collected at birth (per cent optimal birthweight [POBW]). The Trier Social Stress Test was administered to the offspring (Generation 2; Gen2) at 18 years; HPA-A responses were determined (reactive responders [RR], anticipatory responders [AR] and non-responders [NR]). Cardiometabolic parameters (BMI, systolic BP [sBP] and LDL cholesterol) were measured at 20 years. Regression modelling demonstrated linear associations between POBW and BMI and sBP; quadratic associations were observed for LDL cholesterol. For every 10% increase in POBW, there was a 0.54 unit increase in BMI (standard error [SE] 0.15) and a 0.65 unit decrease in sBP (SE 0.34). The interaction between participant’s fetal growth and HPA-A phenotype was strongest for sBP in young adulthood. Interactions for BMI and LDL-C were non-significant. Decomposition of the total effect revealed no causal evidence of mediation or moderation.
Can Policy Responses to Pandemics Reduce Mass Fear?
Authors: Bechtel Michael M. , O’Brochta William , Tavits Margit 
Published: April 2022

AbstractTo successfully address large-scale public health threats such as the novel coronavirus outbreak, policymakers need to limit feelings of fear that threaten social order and political stability. We study how policy responses to an infectious disease affect mass fear using data from a survey experiment conducted on a representative sample of the adult population in the USA (N = 5,461). We find that fear is affected strongly by the final policy outcome, mildly by the severity of the initial outbreak, and minimally by policy response type and rapidity. These results hold across alternative measures of fear and various subgroups of individuals regardless of their level of exposure to coronavirus, knowledge of the virus, and several other theoretically relevant characteristics. Remarkably, despite accumulating evidence of intense partisan conflict over pandemic-related attitudes and behaviors, we show that effective government policy reduces fear among Democrats, Republicans, and Independents alike.
Validierung einer Skala zur Erfassung der depressionsbezogenen Selbstwirksamkeitserwartung (DSW)
Authors: Hesse Savion , Heddaeus Daniela , Steinmann Maya , Wolf Markus , Härter Martin , Watzke Birgit 
Published: April 2022

Zusammenfassung. Erste Befunde indizieren, dass Patientinnen und Patienten mit stark ausgeprägter depressionsbezogener Selbstwirksamkeitserwartung bessere Behandlungsergebnisse erzielen und ein geringeres Rückfallrisiko aufweisen. Bisher existieren jedoch nur englischsprachige validierte Instrumente zur Erfassung des Konstrukts. In der vorliegenden Studie erfolgte eine psychometrische Überprüfung der deutschsprachigen Adaptation (DSW-Skala) der Self-efficacy for Managing Depression Scale ( Bush et al., 2001 ) anhand von N = 377 primärärztlichen Patientinnen und Patienten mit depressiver Symptomatik, die zu Behandlungsbeginn sowie nach 3, 6 und 12 Monaten untersucht wurden. Die Ergebnisse belegten eine gute interne Konsistenz der Skala (Cronbachs α ≥ .85) und akzeptable Retest-Reliabilität ( rtt = .63). Die Responsivität der Skala sowie eine vergleichbare Messstruktur über alle Messzeitpunkte hinweg wurden nachgewiesen. Multiple Regressionsanalysen belegten die Vorhersagekraft der DSW-Skala bezüglich der depressiven Symptomatik über 6 Monate. Die Ergebnisse zeigen, dass die DSW-Skala gängige psychometrische Standards erfüllt, sodass die Skala als zeitökonomisches und reliables Messinstrument in der Praxis und Forschung eingesetzt werden kann.
Destabilization of Long‐Lived Hadean Protocrust and the Onset of Pervasive Hydrous Melting at 3.8 Ga
Authors: Drabon Nadja , Byerly Benjamin L. , Byerly Gary R. , Wooden Joseph L. , Wiedenbeck Michael , Valley John W. , Kitajima Kouki , Bauer Ann M. , Lowe Donald R. 
Published: April 2022

AbstractThe nature of Earth's earliest crust and crustal processes remain unresolved questions in Precambrian geology. While some hypotheses suggest that plate tectonics began in the Hadean, others suggest that the Hadean was characterized by long‐lived protocrust and an absence of significant plate tectonic processes. Recently proposed trace‐element proxies for the tectono‐magmatic settings in which zircons formed are a relatively novel tool to understand crustal processes in the past. Here, we present high‐spatial resolution zircon trace and rare earth element geochemical data along with Hf and O isotope data of a new location with Hadean materials, 4.1–3.3 Ga detrital zircons from the 3.31 Ga Green Sandstone Bed, Barberton Greenstone Belt. Together, the hafnium isotope and trace element geochemistry of the detrital zircons record a major transition in crustal processes. Zircons older than 3.8 Ga show evidence for isolated, long‐lived protocrust derived by reworking of relatively undepleted mantle sources with limited remelting of surface‐altered material. After 3.8 Ga, Hf isotopic evidence for this protocrust is muted while relatively juvenile source components for the zircon's parental magmas and flux‐like melting signatures become more prominent. This shift mirrors changes in Hf isotopes and trace element geochemistry in other Archean terranes between ∼3.8 and 3.6 Ga and supports the notion that the global onset of pervasive crustal instability and recycling—A possible sign for mobile‐lid tectonics—Occurred in that time period.
Olivine Morphology and Fabric During Diffusion Creep: Pure Shear Experiments
Authors: Kim N. , Ando A. , Yabe K. , Hiraga T. 
Published: April 2022

AbstractWe deformed aggregates of Fe‐free olivine +20 vol% diopside in pure shear to study olivine grain morphology and fabric during diffusion creep. Samples were each deformed to a strain of around 0.7 at different temperatures and experimental durations, which resulted in different grain sizes among the samples due to grain growth. The sample microstructures were observed from each of the three principal stress directions, which revealed various 3D grain morphologies among the samples. Samples with tabular grains displayed a crystallographic preferred orientation (CPO) in olivine, while samples with weakly anisotropic grains had uniform CPOs. The CPO patterns vary from AG‐type (i.e., a uniaxial [010] concentration in the direction of sample shortening) to A‐type (i.e [010] and [100] concentrations in the directions of sample shortening and stretching, respectively), with intermediate types being the most common. The transition from AG‐ to A‐type fabrics is accompanied by a change from oblate to prolate grain morphologies. We explain the direct correlation between the olivine morphology and fabrics based on preferential grain‐boundary sliding (GBS) at boundaries with fewer steps (ledges). Oblate morphologies with well‐developed grain boundaries oriented parallel to (010) provide easy GBS along (010) and [h0l] planes and directions, respectively, while relatively prolate morphologies with boundaries parallel to (010) that are elongated along [100] provide easy GBS along (010) and [100] planes and directions, respectively. Boundaries form parallel to a particular crystallographic plane through differential grain growth in the directions of the crystallographic axes. Such grain growth causes fabric transitions during diffusion creep.
Calibration and Application of Branched GDGTs to Tibetan Lake Sediments: The Influence of Temperature on the Fall of the Guge Kingdom in Western Tibet, China
Authors: Liang Jie , Guo Yanlong , Richter Nora , Xie Haichao , Vachula Richard S. , Lupien Rachel L. , Zhao Boyang , Wang Mingda , Yao Yuan , Hou Juzhi , Liu Jianbao , Russell James M. 
Published: April 2022

AbstractBranched glycerol dialkyl glycerol tetraethers (brGDGTs) from lacustrine sediments have been widely used to reconstruct mean annual air temperature (MAAT). Although many proxy calibrations relating brGDGT characteristics have been put forth, these calibrations may produce warm biases when applied to lakes in cold regions. We present an expanded Chinese lake surface sediment brGDGT‐MAAT calibration with 29 new surface samples from cold regions along with 39 previously published from Chinese lakes. We deployed sediment traps in a meromictic lake, Dagze Co, and compared results with previously published data from a dimictic lake, Lake 578 in Greenland, to determine potential seasonal and depth‐dependence of brGDGTs. In the meromictic lake, brGDGTs are primarily produced in the lake bottom water, whereas in the dimictic lake, the brGDGTs are produced throughout the water column and mainly reflect the annual bottom water temperature or mixing season water column temperature. We applied our refined calibration to a sediment core from Western Tibet to examine how fluctuations in temperature influenced the Guge Kingdom over the last 2,000 years. Our record reveals relatively warm temperatures during the Medieval Climate Anomaly, cooling of 2°C to −2°C during the Little Ice Age, warming into the eighteenth century, and stabilization after 1800 CE. The temperature variations coincided with a transition of dynasties in Western Tibet. Temperature sensitivity tests on barley distribution, the principal cultivated cereal in Tibet, suggest that a decline in temperature led to a decreased crop yield that may have factored into the disappearance of the Guge Kingdom.
Regional Map of Molecular Water at High Southern Latitudes on the Moon Using 6 μm Data From the Stratospheric Observatory for Infrared Astronomy
Authors: Honniball C. I. , Lucey P. G. , Arredondo A. , Reach W. T. , Malaret E. R. 
Published: April 2022

AbstractA map of surface molecular water was derived from long slit spectroscopy of the south polar region of the Moon using the Faint Object infraRed CAmera for the SOFIA Telescope spectrometer on the Stratospheric Observatory for Infrared Astronomy. Mean water abundances detected are about 250 μg/g over that of a mare reference surface at Mare Fecunditatis. Water abundances are locally anticorrelated with temperature. The distribution of water is consistent with derivation of water from pre‐existing hydroxyl subsequently trapped in impact glass, provided hydroxyl increases with latitude as some models and measurements suggest. The detected water cannot be in equilibrium with the exosphere because insufficient water is present in the exosphere to maintain the surface abundance. The data are consistent with a high latitude water‐bearing mineral host that may be a precursor to recently detected high latitude hematite.
Shear‐Wave Velocity Structure Beneath Northeast China From Joint Inversion of Receiver Functions and Rayleigh Wave Phase Velocities: Implications for Intraplate Volcanism
Authors: Tang Zheng , Julià Jordi , Mai P. Martin , Mooney Walter D. , Wu Yanqiang 
Published: April 2022

AbstractA high‐resolution 3D crustal and upper‐mantle shear‐wave velocity model of Northeast China is established by joint inversion of receiver functions and fundamental‐mode Rayleigh wave phase velocities. The teleseismic data used to calculate receiver functions are collected from 107 CEA permanent sites and 118 NECESSArray portable stations. Rayleigh wave dispersion measurements are extracted from an independent tomographic study. Our model exhibits significant detail in S wave velocity structure. Particularly, we observe a nearly constant S wave velocity of 3.4–3.6 km/s from shallow to deep crystalline crust under the study area, which we attribute to a high thermal gradient. Some modestly positive S wave velocity anomalies in the crust beneath the Songliao basin are interpreted as solidified late‐Mesozoic mafic intrusions. In the upper mantle, we confirm the local presence of low‐velocity zones below the Changbai mountains and Lesser Xing'an mountain range, consistent with asthenospheric mantle upwelling models. Furthermore, moderately low shear velocities imaged beneath the Halaha and Abaga volcanoes indicate possible pathways of magma ascent through the lithospheric mantle from the asthenosphere. At a regional scale, the average lithosphere‐asthenosphere boundary depth increases from ∼70 km under the greater Changbai mountains to ∼100 km below the Songliao basin, and reaches ∼110–120 km beneath the Greater Xing'an mountain range in the west. The conjectured dense mantle lid under the Songliao basin, characterized by fast S velocities, may have prevented sublithospheric melts from migrating to the surface.
Mechanism of cancer stemness maintenance in human liver cancer
Authors: Liang Ning , Yang Tao , Huang Qian , Yu Pengfei , Liu Chaoxu , Chen Liusheng , Wang Qian , Wang Gang , He Xianli 
Published: April 2022

AbstractPrimary liver cancer mainly includes the following four types: hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), hepatoblastoma (HB), and combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CCA). Recent studies have indicated that there are differences in cancer stem cell (CSC) properties among different types of liver cancer. Liver cancer stem cells (LCSCs), also called liver tumor-initiating cells, have been viewed as drivers of tumor initiation and metastasis. Many mechanisms and factors, such as mitophagy, mitochondrial dynamics, epigenetic modifications, the tumor microenvironment, and tumor plasticity, are involved in the regulation of cancer stemness in liver cancer. In this review, we analyze cancer stemness in different liver cancer types. Moreover, we further evaluate the mechanism of cancer stemness maintenance of LCSCs and discuss promising treatments for eradicating LCSCs.