bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dana Sukuk sebagai Alternative Sumber Dana Pembiayaan pada Bank Syariah
Authors: Nasution Yusuf Wildan , Marliyah Marliyah , Tambunan Khairina 
Published: August 2022

This study looks at the issuance and development of sukuk at Bank CIMB NIAGA Syariah and looks at the utilization of sukuk funds at Bank Cimb Niaga CIMB NIAGA Syariah. The method in this research uses descriptive qualitative, in data collection using documentation techniques with secondary data as the analysis. The purpose of this research is to determine the process of issuance and development of sukuk funds at Bank CIMB NIAGA Syariah and to determine the utilization of sukuk funds at Bank CIMB Niaga Syariah. The function of this research is to be able to increase scientific literature in the field of Islamic capital markets related to Islamic banking, related to Sharia Bank Sukuk. The result of this research is that in the issuance of Sukuk Mudharabah Bank CIMB NIAGA Syariah has followed the POJK rules, which have been explained in several articles related to the issuance of Sukuk Mudharabah. And there is conformity in the Sukuk Mudharabah issuance scheme according to the OJK with the CIMB NIAGA Syariah Bank Sukuk Mudharabah scheme. As for the development of sukuk funds at Bank CIMB NIAGA Syariah, it has been running according to the target in their issuance and it can be said that the bank with the highest value of sukuk registered with the Indonesian Financial Services Authority is Bank CIMB NIAGA Syariah. In utilizing sukuk funds at Bank CIMB NIAGA Syariah, use them to support sharia financing with a musyarakah mutanaqisah (MMQ) financing contract

Keywords: Fund Utilization, Sukuk Mudharabah, Sharia Financing Musyarakah Mutanaqisah
Kewirausahaan Sosial Dalam Perspektif Ekonomi Islam
Authors: Hasibuan M. Hizbullah , M. Nawawi Zuhrinal 
Published: August 2022

Business is a movement to satisfy needs that are overwhelmingly popular by many gatherings. Business venture today has encountered a change in direction from one benefit to another situated to be a social mission. Social business venture/social business exercises viewed as an option in taking care of monetary issues social. As a country where most individuals are Muslims what's more, considering the inescapable development of social business venture, then Islamic financial matters accompanies a perspective on data about the connection between friendly business and the upsides of Islamic regulation. Social exercises business when seen from the execution program plays practically a similar part with the point of Islamic financial matters itself with an end goal to increment development and financial prosperity. This study utilizes the writing survey strategy, in particular by gather a few ideas that are ordered from the exploration factors then, at that point, consolidated into another logical review. Moreover, the reason for making This examination is to add a little reference to the investigation of Social Entrepreneurship in the viewpoint of Islamic Economics.
Keywords : Entrepreneurship, Islamic Economics, Social Entrepreneurship
Targeted Regulation and Cellular Imaging of Tumor-Associated Macrophages in Triple-Negative Breast Cancer: From New Mechanistic Insights to Candidate Translational Applications
Authors: Hooda-Nehra Anupama , L. Smith Tracey , I. Ferrer Alejandra , I. Staquicini Fernanda , Arap Wadih , Pasqualini Renata , Rameshwar Pranela 
Published: August 2022

The complex interplay between immune cells and tumor cells within the tumor microenvironment (TME) can lead to disease progression. Specifically, signals generated in the TME can cause immunosuppression, promoting angiogenesis and immune evasion, which leads to tumor development. The interplay of M1 and M2 macrophage populations that coincide with these tumor markers is particularly important in the TME. Triple-negative breast cancer (TNBC) often presents as advanced disease, and these tumors are also often bereft of recognized molecular targets that can be found in other subtypes, limiting their therapeutic options. However, tumor-associated macrophages (TAMs) infiltration in TNBC is frequently observed. Moreover, a high density of TAMs, particularly M2 macrophages, is associated with poorer outcomes in various cancers, including TNBC. This provides a strong basis for exploiting TAMs as potential therapeutic targets. Specifically, efforts to increase M2 to M1 repolarization are promising therapeutic approaches in TNBC, and four recent studies wherein divergent approaches to target the M2-rich macrophage population and reverse immune subversion are described. These and similar efforts may yield promising diagnostic or therapeutic options for TNBC, a great clinical need.
Predicting Trends, Seasonal Effects, and Future Yields in Cow’s Milk through Time Series Analysis
Authors: Ambachew Taye Birhan , Amsalu Alen Alemayehu , Kalayu Nega Ashenafi , Getnet Yirsaw Bantie 
Published: August 2022

A dairy is a place that is used for handling milk and milk products. Dairy products are basically based on milk. Milk is used to prepare dairy products, such as butter, cheese, and milk powder. There is always a great demand for milk and milk products among people. This study attempted to investigate the trends in the actual yield of cow’s milk production at Andassa dairy farm. We used secondary data for the study of the daily milk production of cows at Andassa dairy farm. The specific objectives of the study were—to identify whether the milk production is time-dependent or not; to predict in which season the milk production is high or low; to examine the daily trend analysis of milk production; to fit the appropriate model; and to forecast the milk production for the future. The study was conducted based on quantitative variables. So, the dependent variable is the average daily milk, and the independent variable is the time measure at which milk production is measured each day. The study used both descriptive and inferential statistics to analyze the data that were collected from the dairy farms in the sector. This study covered a total of 179 days of milk production. The results reveal that the milk yield of cows is declining, and that milk output is time-dependent, according to the time series plot, and that the model is ARIMA.
Lung Transplantation in Idiopathic Pulmonary Fibrosis
Authors: Goetz Ryan , Kumar Jain Nitesh , Anjum Humayun , S. Kaleekal Thomas 
Published: August 2022

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease associated with a high degree of morbidity and mortality in its more advanced stages. Antifibrotic therapies are generally effective in delaying the progression of disease; however, some patients continue to progress despite treatment. Lung transplantation is a surgical option for selected patients with advanced pulmonary fibrosis that increases their overall survival and quality of life. Changes in the Lung Allocation Score (LAS) in 2005 have resulted in increased transplants and decreased waitlist mortality in this population. Indications for transplant evaluation and listing include the clinical progression of the disease and related mortality risk ≥50% at 2 years without a transplant. Patients with clinically rapid deterioration or acute flares needing hospitalization can be bridged to transplant on extracorporeal support while remaining ambulatory and free from mechanical ventilation.
The Effect of Physical Activity Intervention on Panic and Anxiety Symptoms in Children, Adolescents and Early Adulthoods: A Meta-Analysis
Authors: Wang Lin , Liu Yihao 
Published: August 2022

Physical activity is believed to promote mental health. However, research has not yet reached a consensus on whether physical activity declines panic and anxiety symptoms in children, adolescents, and early adulthoods. The current chapter carried out a meta-analysis to investigate the association between physical activity and panic/anxiety based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Search is conducted on 22nd April 2022, which follow databases: MEDLINE (Ovid), EMBASE, Web of Science, Cochrane Central Register of Controlled Trials, and SPORTDiscus. Fifteen articles (N = 994) were identified and included, where four studies reported measurement in panic symptoms and fourteen studies reported measurement in anxiety symptoms. The meta-analysis among the pooled effect sizes demonstrated a small significant effect of physical activity intervention reducing panic disorder (d = −. 45, SE = .12, Z = −3.65, p < .001) and a middle effect reducing anxiety (d = −.51, SE = .15, Z = −3.38, p < .001) in children, adolescents and early adulthoods. Age or gender ratio was not found to be significant in predicting the effect sizes. More evidence is required to produce a solid conclusion.
Analysis and Modeling of Polygonality in Retinal Tissue Based on Voronoi Diagram and Delaunay Tessellations
Authors: Bautista-Elivar Nazario , Cruz-Castillo Ricardo 
Published: August 2022

Several important properties of biological systems are directly related and even determined by the spatial distribution of their constituent elements. Those elements interact with each other and tend to use space in an optimal way, regarding their specific function and environmental constraints. A detailed methodology, based on Voronoi polygons and Delaunay triangles method employed to extract information on the spatial distribution of cells, is presented. On the other hand, diabetic retinopathy (DR) is defined as microvascular pathology. However, some data have suggested that the retinal photoreceptor (RPs) might be important in the pathogenesis of this ocular disease. In this study, the organization of the PRs in control and diabetic-induced rats was compared, using multiphoton microscopy. The PR mosaic was imaged at different locations in non-stained retinas. Thus, this work investigated the pathological changes in the cellular structures of the retina in the early stages of diabetes in laboratory animals. Of the different proposed tools that are highly reliable to be tested with human retinas, the metrics mean averaged distance and the mean square deviation of the angles are found (P < 0.05).
Survival Fate of Hepatic Stem/Progenitor and Immune Cells in a Liver Fibrosis/Cirrhosis Animal Model and Clinical Implications
Authors: Yan Min , Hu Deyu , Wu Zhenyu , Lai Jiejuan , Zhang Leida , Zhang Hongyu , Li Sijin , Bai Lianhua 
Published: August 2022

This chapter provides novel information about the survival features of hepatic resident stem/progenitor cells (NG2+ HSPs) during liver fibrosis/cirrhotic development. A well-defined diethylnitrosamine (DEN)-induced liver fibrosis/cirrhotic/cancer mouse model was developed to evaluate the fate of the HSPs and its clinical implications. This model possess three time-zones during the disease development: fibrosis (3–5 weeks post-DEN), cirrhosis (6–10 weeks post-DEN), and cancers (up to 10 weeks post-DEN). During this process, the model represents histological patterns similar to those described in humans and shows better survival of the HSPs in the fibrotic zone, which was correlated with inflammatory signals, as compared to the cirrhotic zone. It has also been discovered that immune CD8+ T cells in the fibrotic zone are beneficial in liver fibrosis resolution, suggesting that the fibrotic time zone is important for mobilizing endogenous HSPs and cell-based therapy. As such, we hypothesize that clinical strategies in fibrotic/cirrhotic liver treatment are necessary either in time at the fibrotic phase or to adopt an approach of regulating HSP viability when the disease develops into the cirrhotic phase.
Association of Fatness and Leg Power with Blood Pressure in Adolescents
Authors: Musa Danladi , Iornyior Daniel , Tyoakaa Andrew 
Published: August 2022

This cross-sectional study examined the independent and joint association of fatness and leg power (LP) with resting blood pressure (BP) in adolescents (12 to 15 years) in Benue state of Nigeria. The present study comprised 2047 adolescents, including 1087 girls. Participants were assessed for body mass index (BMI), LP, and resting BP. Multivariate regression models assessing the associations of the independent variables with BP were conducted. Fatness and LP were independent predictors of resting BP among participants and the relationship of LP with BP was more robust in girls than boys. Combined fatness and LP in predicting BP was modest (R2 = 10.4–14.3%) after controlling for maturity status. Low LP was associated with systolic blood pressure (SBP) in both girls (R2 = 9.0%, β = 0.260, p = 0.001) and boys (R2 = 11.0%, β = 0.226, p = 0.001). In the model for diastolic blood pressure (DBP), only fatness was associated with BP in girls (p = 0.001). The odd of hypertension (HTN) risk among overweight girls was 2.6 times that compared to their healthy-weight peers. Girls with low LP were 0.40 times more likely to develop HTN risk compared to their counterparts with high LP. This study has demonstrated that lower body muscle power is more important than fatness in predicting HTN in adolescent boys and girls.
Intratracheally Therapeutic Option for COPD: A Potential Usage of the Therapeutic Microbe for Delivering Specific Protein to the Lungs
Authors: Sato Takashi , Shimosato Takeshi 
Published: August 2022

Currently, inhaled therapy using corticosteroids and/or bronchodilators is the major established treatment for chronic obstructive pulmonary disease (COPD). The topic to be covered in this chapter is the recently developed experimental approach using biologically active molecules secreted by the live genetically modified lactic acid bacteria (gmLAB). The strategy to use gmLAB as a therapeutic/delivering tool targeting disease-specific active molecules/cites is proceeding. The role of inflammation and oxidative stress in COPD development is a valid target point. Heme oxygenase (HO)-1 as an anti-inflammatory and antioxidative stress molecule has been examined to attenuate the lung function decline and inflammation in the murine model of COPD. Recently, HO-1-secreting gmLAB as a tool for targeting inflammatory diseases has been developed and examined in several disease models including COPD. When administered intratracheally, the gmLAB showed migration to the peripheral lung and overexpression of anti-inflammatory/oxidative HO-1 in both lung and serum, protecting the lung from COPD development.
Analysis of Constraints Faced by Startups in the Food Processing Industries in Tamilnadu, India
Authors: Murugan R. Arul , Karthikeyan C. , Devi M. Nirmala 
Published: August 2022

Food processing sector is the transformation of raw agricultural products into food or one form of food into other forms. Food processing comprises many forms of processing foods starting from grinding grain to make raw flour to home cooking to complex industrial methods of food processing and it is used to make convenience foods. The Indian Food and Beverage Industry is evolving as a high-profit sector and contributes about 3 % of India's GDP with the value of two-thirds of the total retail market in India. The projected revenue in the food and beverage business segment is estimated to show a CAGR growth rate of 14.2 percent from the year 2020 to 2024. The study was carried out in June 2022 with the objective is to analyze the constraints faced by startups in the food processing industries, for this study 30 key informants were selected from each start-up food processing industry in three districts namely Trichy, Dindugal, and Coimbatore and all the three districts, the Key Informants was asked collectively to list the constraints faced by the start-up food processing industry through the participatory method. The Rank Based Quotient (RBQ) value for the insufficient connection between production and processing is 84.67 and ranked first among the infrastructure constraint which implies that lack of infrastructure godowns for storage and linkages with the traders. The delay in sanction of loans was the major constraint with RBQ of 76.67 and ranked first among the policy constraint. The delay in sanction of loans makes the new startups innovate the new products in the market, which bags their product diversification in the market. The tedious channels for financial transactions with an RBQ value of 59.33 and a high rate of interest for loans with an RBQ of 57.33. The lack of knowledge on Post-harvest technologies with an RBQ value of 70.67, shows the lack of training on the handling of new and improved post-harvest equipment for product diversification. In the marketing constraint, the challenges in identifying the specific market for the product was ranked first among the marketing constraint with an RBQ value of 77.33. The hindrance in the identification of specific market for their produce bags their profit, they forced to sale their produce in markets in which they will not able to get better remunerative for their produce. The Policy would seek to create a favorable environment for the Agri-preneurs to start Food Processing sectors through fiscal initiatives/interventions, which will facilitate the establishment of low-cost pre-cooling and cold chain units proximal to the agricultural farms. It also facilitates the establishment of cold storage units and sorting grading, and hi-tech packing facilities to reduce post-harvest wastages and improve the quality of products and the shelf life.
Evidence-based Recommendations to Improve Retention, Attraction and Recruitment of Health Workers in Sudan
Authors: Y. Hammad Almoeiz , Khatim Osama , A. Abdalla Moneer , A. Abdalla Murtada 
Published: August 2022

Background: Current literature systematically reports that interventions to retain and attract health workers in underprivileged areas need to be context specific but rarely defines what that means. In this systematic review, the study summarized and evaluates context factors influencing the enforcement of interventions to attract and retain health workers in rural area.
Methods: We searched online databases, pertinent websites and reference lists of selected papers to identify studies on mandatory rural service programs and financial rewarding. Four studies were selected. Information regarding context factors at macro, meso and micro levels was extracted and re-synthesized.
Conclusion: In all the articles reviewed, policies were in placement to hold health workers, the policies appear to be ineffective because workers are still animated from rural to urban areas and from Sudan abroad. There is an utmost need than constantly before for national-level overall policy formularization on non-financial and financial remuneration if there is to be refinement in the unjust distribution of health workers across the region.
Effect of Intra Cardiac Shunts on Left Ventricular Systolic Function: A Speckle Tracking Study
Authors: Nasef Muhammad Zakaria , Shaban Aliaa Elsayed , Abd-Allah Timoor Mostafa , Elsheikh Raghda Ghonimy 
Published: August 2022

Background: The left ventricular (LV) chamber size and its systolic function is the most common and quickest assessment made by echocardiography, either in the intra operative or intensive care setting, being the pressure generator for the blood supply to the body .Congenital cardiac defects come in two main types: atrial and ventricular septal defects (ASD/VSD). Regression or spontaneous closure may be the natural course of minor septal defects.
Aim and Objectives: The aim of the study was to assess the feasibility of speckle tracking echocardiography in estimation of left ventricular systolic function in congenital shunt lesions (ASD, VSD and PDA).
Subjects and Methods: This study was done in Tanta University Hospital including 270 patients. The patients were divided into four groups: ASD patients, VSD patients, PDA patients and control subjects.
Results: It showed statistically significant difference between ASD, PDA and control group. The difference between the PDA group and the control group was statistically significant. There was a statistically significant difference between the ASD group and the control group in terms of EF percent, FS percent, and ESV ROC curve for Validity of GLS to predict LV systolic dysfunction in PDA Group. Sensitivity was 68 and sensitivity was 80.
Conclusion: It was determined that Speckle-tracking echocardiography offers an additional non-invasive method for evaluating patients' left ventricular function. With congenital shunt lesions.
Design of SILT+3 Floor Building Using STAAD Pro
Authors: Swetha Maroju , Harihanandh M. 
Published: August 2022

This project describes design and analysis of a S+3 floor building using Staad pro. The design and analysis will be carried out with Staad pro software. The main consideration for designing a building is the structural design which plays a major role for specifying the shape and size of the structural members which are designed for different loads and moments acting on the structure. These loads and moments are to be distributed to each and every structural members like beams which transfer loads to the columns and then transferred to footings.
STAAD Pro is anadvanced software developed by “BENTLEY” which is used for designing structural elements in various aspects with accurate results saving the time.
My project is to DESIGN OF SILT +3 FLOOR BUILDING USING STAAD Pro considering all loading conditions using Stand pro.
Annona muricata Linn Stem Bark Protects against Uterine Proliferative Disorder Induced by Estradiol Benzoate in Female Rat
Authors: Olowofolahan Adeola Oluwakemi , Dare Heritage Mojisola , Adeoye Yemisi Dorcas , Olorunsogo Olufunso Olabode 
Published: August 2022

Aim: The opening of mitochondrial permeability transition (mPT) pore is an important event in the execution of mitochondrial-mediated apoptosis. Some bioactive compounds elicit their chemotherapeutic effects against tumor/cancer cells via the induction of mitochondrial-mediated apoptosis. Annona muricata, a medicinal plant, is folklorically used in the treatment of tumors and cancers. This study therefore aimed at investigating the effect of methanol stem bark extract of Annona muricata (MEAM) on apoptosis via mPT pore and estradiol benzoate (EB)-induced proliferative disorder using female Wistar rats.
Methodology: Mitochondria were isolated using differential centrifugation. The mPT pore opening, cytochrome c release and mitochondrial ATPase activity were determined spectrophotometrically. The levels of estrogen (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH), malondialdehyde (MDA) and activities of superoxide dismutase (SOD), glutathione peroxidase (GSH), were determined using ELISA technique. Histological and histochemical assessments of the uterine sections were carried out using standard methods. Phytochemical constituents of MEAM were determined using Gas Chromatography-Mass Spectroscopy (GC-MS).
Results: The in vitro results showed a significant induction of mPT pore opening, release of cytochrome c and enhancement of mitochondrial ATPase (mATPase) activity in a concentration-dependent manner. However, oral administration of MEAM did not induce rat uterine mPT pore opening, neither any significant release of cytochrome c nor enhancement of mATPase activity at the dosages used. Interestingly, MEAM reversed the EB-induced increase in E2, LH and FSH. The MEAM also improved the antioxidant milleu by reducing MDA level and increasing the SOD and GSH-Px activities in the treatment groups. Administration of EB induced endometrial hyperplasia in the model group which was mitigated by MEAM in the treatment group. The GC-MS analysis of MEAM revealed the presence of some important phytochemicals that are pharmacological relevant in cancer treatment.
Conclusions: This study suggests that the methanol stem bark extract of Annona muricata contains bioactive compounds that protect against EB-induced uterine proliferative disorder in female Wistar rats.