bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface quality and cylindricity of ultrasonic elliptical vibration assisted centerless grinding of micro-rod YAG single crystals
Authors: Hu Yuxiu , Li Chen , Wang Xin , Geng Yanquan , Xiao Guijian , Zhang Feihu 
Published: September 2022

Abstract
Micro-rod YAG single crystals are the most commonly used laser crystals for laser gain mediums with a high power. However, brittle fracture and crack damages are easy to occur in the grinding process of micro-rod brittle crystals due to their large length-to-diameter ratio, high brittleness and high hardness. In this work, the modal, frequency and harmonic response of the transducer under ultrasonic elliptical vibration are analyzed by using finite element simulation. Then, the mechanical structure of ultrasonic elliptical vibration system was designed and optimized based on the ultrasonic elliptical vibration theory and finite element simulation. To verify the reliability of the transducer, ultrasonic vibration experiments were are carried out to measure the resonance frequency, amplitude and impedance characteristics of the transducer. The vibration synthesis experiments under different phase differences and different voltages were performed to verify the rationality of the structural design of the ultrasonic elliptical vibration system. An experimental platform of ultrasonic elliptical vibration assisted centerless grinding was developed, and UEVCG tests of micro-rod YAG crystals were performed. The influences of voltage, phase difference and pallet angle on surface roughness, PV value and cylindricity of the micro-rod YAG crystals were systematically analyzed. The ultrasonic elliptical vibration parameters were optimized based on the range analysis results of the orthogonal test. The results indicated that ultrasonic elliptical vibration effectively improved the surface quality and cylindricity of the micro-rod YAG crystals compared with traditional grinding. This work will not only enhance the understanding of the ultrasonic elliptical vibration principle, but also provide a technical support for precision and high-efficiency machining of micro-rod brittle materials.
Indoor air quality study among the households of Ulaanbaatar, Mongolia
Authors: Galsuren Jargalsaikhan , Gombojav Enkhjargal , Boldbaatar Buyantushig , Munkhtur Nansalmaa , Namnan Bayarjargal , Shagdar Urantsetseg , Vanya Delgermaa , Lkhagvatseren Urangua , Dambadarjaa Davaalkham 
Published: September 2022

Abstract
This study was conducted to compare whether the indoor air pollutants had changed in 2020 compared to 2019 in accordance with the raw coal use ban. A total 295 households and 10 family health centers were recruited from 6 districts of Sukhbaatar, Bayangol, Chingeltei, Songinokhairkhan, Khan-Uul and Bayanzurkh districts of the Ulaanbaatar city. The average 24-hour concentration of fine particles is 102.7 µg/m3 in total households, which is 2.1 times higher than the Mongolian air quality standard. The average concentration of PM2.5 which was measured in 2019, when the raw coal usage was available, is decreased by 40 percent (from 176.1 µg/m3 to 105.7 µg/m3) compared to the year of 2020 when improved fuel usage was introduced. Particulate matter pollution varied significantly by dwelling and heating types. The concentration of indoor PM2.5 was relatively high (128.4-150.2 µg/m3) in gers and houses with traditional stoves, whereas it was low (81.2–86.3 µg/m3) in gers and houses with improved stoves. PM2.5 concentrations varied diurnally in gers, houses and apartments with peak concentrations from 07:00 to 11:00 in the morning (68–96 µg/m3) and from 18:00 to 20:00 in the evening (71-85.5 µg/m3). PM2.5 concentrations varied by district, with relatively low concentrations in Khan-Uul and Sukhbaatar districts (87.9 µg/m3) as compared to households in Songinokhairkhan and Bayanzurkh districts (108.1 µg/m3). The average 24-hour concentration of carbon monoxide was 17.6 ± 9.2 mg/m3 in gers and houses, which is 2.5 times higher than the WHO recommended level with higher concentrations in houses than in gers. Compared to the winter of 2019 (176.1 µg/m3), the mean concentration of PM2.5 was measured as 105.7 µg/m3 (40% lower) in gers/houses who used refined/improved "Good" fuel in Jan-Feb of 2020. Thus, indoor PM2.5 concentration in gers and houses had decreased significantly (p < 0.05) in winter when improved fuels usage was introduced.
Identification and Analysis of Hub Transcriptional Factors Related to Acetaminophen-Induced Liver Injury
Authors: Yao Jia , Zhao Qiang , Bai Jinjia , Wang Han , Yao Ruoyu , He Jinfan , Zhang Xin , Zhou Xiaoshuang 
Published: September 2022

Abstract
Background Acetaminophen-induced liver injury
(AILI) is one of the most common causes of acute liver failure, and
its pathogenesis remains unclear and there is a lack of effective
early diagnostic markers.

Material and Methods Based on bioinformatics ,
GEO databases and TF databases，we identify and analyze the hub TFs
in AILI and further evaluate the value of these TFs in the early
diagnosis of AILI.

Results A total of 97 AILI-related
differentially expressed transcriptional factors (DETFs) were
obtained, which were mainly enriched in the transcriptional
activity, rhythmic process, cell fate commitment, liver
development, and hepaticobiliary system development. Ten hub TFs
(MYC, TP53, CEBPB, FOXM1, E2F1, EGR2, FOSL1, JUND, E2F7 and E2F8)
were obtained from the PPI networks. In the early stage of AILI,
the expressions of MYC, TP53, CEBPB, E2F1, JUND, and E2F7
significantly changed compared with the control group (all
P<0.05), and these hub TFs had high sensitivity and
specificity(all AUC ≥0.9); in contrast, the expressions of FOXM1,
EGR2, FOSL1 and E2F8 were not significantly different from those in
the control group (all P＞0.05), and these hub TFs had
certain sensitivity and specificity(all 0.67
≤AUC≤0.79).

Conclusions Ten hub TFs (MYC, TP53, CEBPB,
FOXM1, E2F1, EGR2, FOSL1, JUND, E2F7 and E2F8) are closely related
to AILI, among which MYC, TP53, CEBPB, E2F1, JUND, and E2F7 have
better diagnostic performance for AILI in its early stages. These
findings further understand the pathogenesis of AILI and provide
new diagnostic markers for the early diagnosis of AILI.
A technical guide to TRITEX, a computational pipeline for chromosome-scale sequence assembly of plant genomes
Authors: Marone Marina Püpke , Singh Harmeet Chawla , Pozniak Curtis J , Mascher Martin 
Published: September 2022

Abstract
Background
As complete and accurate genome sequences are becoming easier to obtain, more researchers wish to get one or more of them to support their research endeavors. Reliable and well-documented sequence assembly workflows find use in reference or pan-genome projects.
Results
We describe modifications to the TRITEX genome assembly workflow motivated by the rise of fast and easy long-read contig assembly of inbred plant genomes and the routine deployment of the toolchains in pan-genome projects. New features include the use as surrogates of or complements to dense genetic maps and the introduction of user-editable tables to make the curation of contig placements easier and more intuitive.
Conclusion
Even maximally contiguous sequence assemblies of the telomere-to-telomere sort, and to a yet greater extent, the fragmented kind require validation, correction, and comparison to reference standards. As pan-genomics is burgeoning, these tasks are bound to become more widespread and TRITEX is one tool to get them done. This technical guide is supported by a step-by-step computational tutorial accessible under https://tritexassembly.bitbucket.io/. The TRITEX source code is hosted under this URL: https://bitbucket.org/tritexassembly.
Higher lactate clearance is needed in septic patients with more serious delayed resuscitation: a retrospective cohort study based on MIMIV-IV database
Authors: Liu Taotao , Wang Mei , Yan Xiaoyu , Shi Zhan , Chang Zhigang 
Published: September 2022

Abstract
Background: For patients with delayed resuscitation, the relationship between the lactate clearance (LC) at different periods after the peak lactate level (LACpeak) and mortality is unclear.
Purpose: To explore how higher lactate clearance is suitable for septic patients with different delayed resuscitation times.
Methods: The study retrospectively screened patients with sepsis admitted, from 2008 to 2019, to the ICU within 24 h and who were recorded in the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Patients with an initial lactate concentration of 2±0.5 mmol/L and an LACpeak ≥2 mmol/L within 24 hours were included. The baseline data and 28-day mortality were collected. The LACpeak within 24 hours and the following lactate concentrations (LACnext) at 3±1 h, 6±2 h, and 11±3 h were recorded. The LC was calculated. The patients were assigned to the delayed resuscitation group and the nondelayed resuscitation group according to whether the time from the initial lactate level to LACpeak was more than 6 hours. The mortality of the groups whose LC was higher than 10%, 20%, and 30% or not within 3, 6, and 11 hours, respectively, was compared, and survival curves were drawn.
Results: 53,150 medical records were retrospectively screened, and 688 patients with sepsis were enrolled, including 337 patients with delayed resuscitation. The mortality of the delayed resuscitation group was higher than that of the nondelayed resuscitation group [80 (23.74%) vs. 49 (13.96%), P=0.001]. In the delayed resuscitation group, the mortality of the patients with a 6-hour LC greater than 20% was lower than that of the patients with a 6-hour LC less than 20% [17 (19.8%) vs. 16 (36.4%), P=0.040]. Significant differences in mortality appeared between the nonsurvivors and survivors when the 11-hour LC reached 30% [4 (12.9%) vs. 29 (29.3%), P=0.033] but not 20% [10 (23.8%) vs. 23 (26.1%), P=0.855].
Conclusions: When the time to peak lactate level exceeds 6 hours as sepsis resuscitation is delayed, mortality can be reduced if the LC reaches 20%, not 10%, in the following 6 hours. LC was needed to reach 30% to reduce mortality if the subsequent resuscitation persisted over 11 hours.
Blockchain Based Secured Vehicle Insurance Framework using Hyperledger Composer
Authors: Hombalimath Archana , Mangla Neha 
Published: September 2022

Abstract
The manual settlement of traditional vehicle insurance policies is atroublesome operation. The settlement procedure is difficult due to anumber of factors, including concealed requirements from the insurer orcharges of fraud by the insured. Additionally, this method takes a longperiod, which makes it incredibly ineffective. The use of blockchain technologyand smart contracts in the vehicle insurance industry has thepotential to completely alter this situation. Any transaction or modificationto a block is made following the decentralized validator entity,not a specific individual. The smart contract is a special feature that isrecorded on the blockchain and is activated when certain requirementsare met. This study proposes a framework for using blockchain-basedsmart contracts for vehicle insurance contracts. A private hyperledgernetwork is used to host this blockchain and intelligent contract-basedinfrastructure. The JavaScript programming language is used to createsmart contracts. To verify the transactions, the system employsthe Proof of Authority consensus mechanism. This framework canaddress all the safety and confidence problems associated with traditionalinsurance policies through the deployment of blockchain technology.
Delayed gastric emptying in robotic pancreaticoduodenectomy
Authors: Mao Shih-Hao , Shyr Bor-Shiuan , Chen Shih-Chin , Wang Shin-E , Shyr Yi-Ming , Shyr Bor-Uei 
Published: September 2022

Abstract
The study of robotic pancreaticouodenectomy (RPD) focusing on delayed gastric emptying (DGE) is seldom reported. This study explored the incidence of DGE in RPD with extracorporeal hand-sewn gastrojejunostomy involving downward positioning of the stomach. Patients with periampullary lesions undergoing RPD or open pancreaticouodenectomy (OPD) were included for comparison. A variety of clinical factors were evaluated for the risk of developing DGE. There were 409 (68.2%) RPD and 191 (31.8%) OPD in this study. DGE occurred in 7.7% of patients after pancreaticoduodenectomy, with 4.4% in RPD and 14.7% in OPD, p < 0.001. Nausea/vomiting (12.6% vs. 6.3%) and jaundice (9.9% vs. 5.2%) were significant preoperative risk factors for DGE, while malignancy (8.7% vs. 2.2%) and lymph node involvement (9.8% vs. 5.6%) were significant pathological risk factors. Intraoperative blood loss > 200 c.c. was the other factor related to DGE (11.2% vs. 4.4% in those with blood loss ≤ 200 c.c.). None of the postoperative complications was significantly associated with DGE. Hospital stay was significantly longer in the group with DGE (median, 37 vs. 20 days in the group without DGE). After multivariate analysis by binary logistic regression, compared with OPD, RPD was the only independent factor associated with a lower incidence of DGE. RPD with extracorporeal hand-sewn antecolic, antiperistaltic, and inframesocolic gastrojejunostomy via a small umbilical wound involving careful downward positioning of the stomach was associated with a low incidence of DGE and presented as the most powerful independent predictor of this condition.
Impact of silvopastoral system on the soil physicochemical properties in China: A meta-analysis
Authors: Wang Junwen , Qin Xinyi , Tan Youquan , Yang Yuhan , Ping Xiaoyan 
Published: September 2022

Abstract
Silvopastoral system has been proposed as a sustainable management system with both ecological and economic benefits compared with open pasture. However, little research compared the ecological impact of silvopastoral system compared with pure forest. Therefore, this study focused on the ecological benefits of silvopastoral system on the soil physicochemical properties under different construction modes and construction periods in China based on meta-analysis. From 29 references we extracted a total of 492 paired data that were used for the meta-analysis. Results showed that silvopastoral system could improve soil physical properties by decreasing soil bulk density and soil pH value. However, no consensus conclusion could be found on soil water content except significant increase in surface soil water content in southern China. Silvopastoral system significantly improved the top-soil nutrient contents. Construction of silvopastoral system significantly increased soil available nitrogen contents of all three soil depths and soil available phosphorus content of 0-40cm soil depth. However, no significant effect could be found for soil available potassium content. Silvopastoral system significantly improved soil organic matter content for all three soil depths. Sub-group analysis showed that 2–3 years after construction of silvopastoral system maximally improved soil available nitrogen and phosphorus contents, while soil available potassium content decreased with the construction period. Our results showed that short-term period construction of silvopastoral systems are effective practices to increase soil nutrient content especially in the temperate climate zone. However, we still need long-term monitoring experiments to verify the long-term ecological effect of silvopastoral system.
Expression of ABCB1, ABCC1 and 3 and ABCG2 in glioblastoma and their relevance in relation to clinical survival surrogates.
Authors: Roy Laurent-Olivier , Lemelin Myriam , Blanchette Marie , Poirier Marie-Belle , Aldkihl Salman , Fortin David 
Published: September 2022

Abstract
Purpose
Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumors in adults. Patients invariably relapse during or after first-line therapy and the median overall survival is 14.6 months. Such poor clinical response is partly ascribed to the activity of ATP-binding cassette (ABC) transporters. The activity of these proteins, severely reduces the amount of therapeutics that penetrates the tumor cells. We hypothesized that ABC transporter expression could correlate with survival surrogates. In this study, we assessed the expression of four commonly expressed ABC transporters in GBM samples and investigated if mRNA levels could serve as a prognostic biomarker.
Methods
Human specimens were analyzed by qPCR to assess ABCB1, ABCC1/3 and ABCG2 expression. Kaplan-Meier and multivariate analyses were then used to evaluate the correlation with overall survival (OS) and progression-free survival (PFS).
Results
Our cohort included 22 non-tumoral samples as well as 159 GBM tumor specimens. ABC transporters were significantly more expressed in GBM samples compared to non-tumoral tissue. Moreover ABCC1 and 3 mRNA expression were significantly increased at recurrence. Statistical analyses revealed that increased expression of either ABCC1 or ABCC3 did not confer a poorer prognosis. However, increased ABCC1 mRNA levels did correlate with a significantly shorter PFS.
Conclusion
In this manuscript, the analyses we conducted suggest that the expression of the four ABC transporters evaluated would not be suitable prognostic biomarkers. We believe that, when estimating prognosis, the plethora of mechanisms implicated in chemoresistance should be analyzed as a multi-facetted entity rather than isolated units.
Design of B/N co-doped heterostructural carbon electrodes from CNF/BNNS/ZIF-8 nanocomposites for advanced supercapacitor
Authors: Shang Zhen , An Xingye , Liu Liqin , Nie Shuangxi , Baker Fiona , Cao Haibing , Cheng Zhengbai , Liu Hongbin , Ni Yonghao 
Published: September 2022

Abstract
Boron (B) and nitrogen (N) co-doped 3D hierarchical porous carbon (BNPC) were successfully fabricated from CNF/BNNS/ZIF-8 nanocomposites prepared by 2D boron nitride nanosheets, ZIF-8 nanoparticles, and wheat straw based cellulose nanofibers. Herein, CNF/ZIF-8 acts as versatile skeleton and imparts partial N dopant into porous carbon structure, while the introduced BNNS can help strengthen the hierarchical porous superstructure and endow abundant B/N co-dopants within BNPC matrix. The obtained BNPC electrode possesses a high specific surface area of 505.4 m2/g and high B/N co-doping content with desirable hydrophilicity. Supercapacitors assembled with BNPC-2 electrode exhibited advanced electrochemical performance with high capacitance stability even after 5000 charge-discharge cycles, exhibited outstanding energy density and power density characters, and the highest specific capacitance of 433.4 F/g at 1.0 A/g, compared with other similar reports. This study proposes a facile and sustainable strategy for efficiently fabrication of rich B/N co-doped hierarchical porous carbon electrodes from agricultural waste biomass for advanced supercapacitor performance.
A novel approach for an approximate solution of a nonlinear equation of charged damped oscillator with one degree of freedom
Authors: Zekry Marwa , Moatimid Galal , Abou-Dina M. S. , Ghaleb A. F. 
Published: September 2022

Abstract
A novel technique is proposed for nding an approximate solution of the strongly nonlinear ordinary dierential equation for the charged damped pendulum with one degree of freedom. The method relies on a transformation of the governing nonlinear dierential equation that keeps unchanged the order of the highest derivative, in conjunction with a modied homotopy perturbation technique (MHPM). Only quadratic damping is considered for the numerical computations. To validate the used technique, the obtained results are compared to those arising from a numerical solution by Runge-Kutta of the fourth order (RK4) and by nite dierences (FD). Good agreement between the two solutions is reached when quadratic damping is suppressed. In the presence of damping, agreement takes place only for a rather limited range of times. Plots of the analytical solutions are provided for both cases. The proposed method may be used to analyze a wide class of nonlinear dierential equations.
Pharmacokinetic and Toxicological Evaluation of Hypophyllanthin Loaded Liposomes
Authors: Parvathaneni Madhukiran , Battu Ganga Rao , Boppana Naga P. D. , Kommineni Nagavendra 
Published: September 2022

Abstract

Phyllanthus amarus (P. amarus) is a broad-spectrum medicinal plant and studies have reported anticancer activity of P. amarus to the presence of bioactive lignans such as Phyllanthin and Hypophyllanthin. In vivo studies have shown that hypophyllanthin is a potent inhibitor of cytochrome p450 enzymes (Phase I enzymes) and exhibits cytotoxic effects on K-562 cells. The most common route of drug administration is via oral, and hypophyllanthin, being poorly soluble in water (lipophilic), is highly unsuitable for oral administration. To improve the aqueous solubility and pharmacokinetic profile, hypophyllanthin is formulated as stealth liposomes. The liposomes are developed using film hydration technique and are evaluated for various physicochemical parameters. The synthesized liposomes were found to be in the size range of 128 to 205 nm, PDI was found in the range of 0.2 to 0.3, encapsulation efficiency was found to be in the range 62 to 85, the zeta potential was found in the range of -32 to -40 mV respectively. The pegylated liposome (HPL7) showed superior pharmacokinetics and 86.05% of drug was released over 24 hours. The safety and efficacy of test formulations were established by toxicity and pharmacokinetic studies. The obtained results indicates that, pegylated liposomes are safest and ensures the maximum circulation half life (t1/2), MRT and low elemination constant(Kel) compared to conventional liposomes and pure phyllanthin drug.
Relaxation dynamics transition near the dry-wet transition in foams
Authors: Yanagisawa Naoya , Kurita Rei 
Published: September 2022

Abstract

Liquid foams respond plastically to external perturbations over some critical magnitude. This relaxation process is directly related to the mechanical properties of the foams, playing a significant role in determining foam lifetime, deformability, elasticity, and fluidity. In this paper, we experimentally investigate the relaxation dynamics of foams near a dry-wet transition. When a foam transforms from a dry state to a wet state, it is found that the relaxation mode changes from sequential T1 events to collective rearrangements. We show that this mode transition is closely related to the change in local bubble arrangements and mobility. Furthermore, it is also found that a probability of relaxation events occurring follows a Poisson distribution, suggesting that there is little correlation between discrete relaxation events. These results constitute progress in understanding the dynamical properties of soft jammed systems, relevant for biological and material sciences as well as food science.