bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of differentiated application of nitrogen fertilizers on the yield of potatoes (Solanum tuberosum L.) of the Snegir variety
Authors: Shchuklina О. A. 
Published: March 2022

Relevance. Potatoes belong to crops that place high demands on the level of mineral nutrition. He needs nitrogen especially badly. Timely introduction of calculated doses of nitrogen fertilizers based on the results of photometric diagnostics of plants allows rational use of fertilizers and increase potato yields.Material and methods. The studies were carried out in the conditions of the Central region of the Non-Chernozem zone on sod-podzolic medium loamy soils with a high content of mobile forms of phosphorus and potassium and a low humus content (1,9%). The object of research is an early-ripening potato variety Bullfinch. To recalculate the dose of nitrogen fertilizing, photometric diagnostics of crops was carried out with an optical sensor GreenSeeker RT200. Additionally, before and after fertilizing, a manual N-tester Yara was examined. Before the main harvest, a control digging of tubers was carried out to determine the structure of the crop with division into 4 fractions.Results. It was found that the introduction of nitrogen fertilizers into the top dressing during the closing phase of the tops in the form of ammonium nitrate has a generally favorable effect on the growth and development of potatoes. This is confirmed by the results of photometric diagnostics performed by the Yara N-tester during the withering phase of the tops. When applying top dressing with a fixed dose, the N-tester readings were 21,7% higher than in the control, and when applying fertilizers with a differentiated dose by 25,6%. The yield of potato tubers increased when applying a fixed dose of top dressing by 10,8%, differentiated by 14,5% compared to the control.
An Overview Of Self-Control In Adolescent With Nomophobia (No Mobile Phone Phobia)
Authors: Ilmiah Gt. Ihda Wardatul , Yusuf Ah. , Tristiana RR Dian 
Published: March 2022

Introduction: Self control is important to control the use of smartphones to suit their needs. Low self control is one of the factors that cause nomophobia in smartphone users. The purpose of this study was to gain an understanding of the self-control of adolescents with nomophobia.Method: This study used a qualitative design with a phenomenological descriptive method through in-depth interviews. There were 15 participants with nomophobia, selected using purposive sampling technique. Data were analyzed using Colaizzi analysis. Results: This study identified 12 themes. Self-control of adolescents with nomophobia is influenced by the use of smartphones which raises the theme of reasons for using smartphones, conditions that cause smartphone use, the use of smartphones in life, and various features used on smartphones. Low self control causes adolescent to have difficulty controlling the stimulus to always use a smartphone and trigger nomophobia which is described through the theme of the response of nomophobia, the aspect of nomophobia, and the impact of nomophobia. After experiencing nomophobia, adolescents do self-control to control the impact of smartphone use which raises the theme of self-control efforts, parental control, and the aspects of self-control. Adolescent self-control is influenced by sources and barriers that raise the theme of the sources of self- control and the barriers of self-control.Conclusions: Adolescents with nomophobia have low self-control in using smartphones and controlling self-responses when there is no smartphone. Therefore, adolescent self-awareness and the role of parents are needed to increase self-control to prevent nomophobia and the negative impact of excessive smartphone use.
The Relationship Between Parent’s Role with Independence of Children with Mental Retardation During Pandemic
Authors: Ngongo Heni Adrianus , Trishinta Sirli Mardianna , Hastutiningtyas Wahidyanti Rahayu 
Published: March 2022

Introduction: The purpose of this study is to determine the relationship of the role of parent with independence of children with mental retardation during the pendemi in SLB N Waibakul District of Central Sumba.Method: The design of the study using the design of the analytic correlation with cross sectional approach. Study population a total of 40 parents who have children with mental retardation in SLB N Waibakul District of Central Sumba and the research sample as many as 40 respondents with the determination using Total Sampling. Techniques of data collection using the instrument in the form of questionnaires, the role of parents and the questionnaire independence of the child with mental retardation. Data analysis methods in use is the Chi Square test.Results: The results of the research prove the majority of 21 (52,5%) respondents gave the role to children with mental retardation during the pendemi the category of less and most of the 22 (55,0%) children with mental retardation experience the independence of the category of dependence currently. The results of the Chi Square test showed a significant relationship, the role of parents with the independence of children with mental retardation during the pendemi in SLB Waibakul District of Central Sumba obtained p value (0,000) < (0,05). Conclusions: The is a significant relationship the role of parents with the independence of children with mental retardation during the pendemi in SLB N Waibakul District of Central Sumba.
Barriers towards the Prevention and Treatment of Malaria among Pregnant Women at the Nkwen Health Center Bamenda, Cameroon
Authors: Nkfusai Ngwayu Claude , Cumber Samuel , Bede Fala , NjokahWepngong Emerson , Tambe Tabe , Wirsiy Frankline , Achu Jacintha , Suh Bih , Anyang Frankline , MahlakoTsoka-Gwegweni Joyce 
Published: March 2022

Malaria remains an important public health problem such that, assessing the challenges experienced among pregnant women (vulnerable) with the uptake of malaria prevention methods and treatment is pertinent. This hospital-based cross-sectional descriptive study that was carried out at a Medicalized Health Center in Nkwen, Cameroon, sought to assess the barriers to malaria prevention faced by 51 pregnant women who attended antenatal clinic (ANC). Over 88% of participants were 15-30 years old. All participants knew at least one symptom of malaria, with 20% of them confirmed to have taken intermittent preventive treatment in pregnancy (IPTp) and 53% reported using insecticide-treated bed net (ITN). Educating pregnant women and their spouses on the uptake of IPTp and the use of ITN is a key strategy to curb its high malaria morbidity and mortality rates.

Copyright © 2022 Nkfusai et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.
National Trends in Hospitalization, Surgical Resection, and Comorbidities in Pediatric Inflammatory Bowel Disease in the United States, 2002-2015
Authors: Ihekweazu Faith D. , Dongarwar Deepa , Salihu Hamisu M. , Kellermeyer Richard 
Published: March 2022

Background and Objective: Therapeutic options for pediatric inflammatory bowel disease (PIBD) have dramatically changed over the last 20 years. However, the impact of modern medical management on PIBD outcomes remains unclear. We aimed to fill this gap in the literature by using a large, validated, national database, to study the change in hospitalization rates, surgical rates, and postoperative complications in PIBD over the last decade.
Methods: The National Inpatient Sample (NIS) Database and ICD-9-CM codes were utilized to identify inpatient admissions with a primary or secondary diagnosis of pediatric Crohn’s disease (CD) or ulcerative colitis (UC) from 2002-2015. Trends in hospitalizations, comorbidities (including malnutrition and weight loss), surgical procedures, and postoperative complications were examined using joinpoint regression analysis, a statistical modeling approach to evaluate the extent to which the rate of a condition changes over time.
Results: There were 119,282 admissions for PIBD during the study period. The annual incidence of hospitalization increased significantly over time for both CD (average annual percent change [AAPC] 6.0%) and UC (AAPC 7.2%). The rate of intestinal resection decreased in CD patients (AAPC -6.4%) while postoperative complications remained unchanged. However, comorbidities increased significantly in CD patients (AAPC 6.8%). For pediatric UC patients, postoperative complications (AAPC 6.7%), and comorbidities (AAPC 10.2%) increased significantly over time while intestinal resection rates remained stable. Intestinal resection rate in pediatric CD has decreased over time, but not in pediatric UC.
Conclusion and Global Health Implications: Annual incidence of hospitalization and comorbidities continue to increase in PIBD. Intestinal resection rate in pediatric CD has decreased over time, but not in pediatric UC. Our findings emphasize the critical need for prevention and novel therapeutic options for this vulnerable patient population.

Copyright © 2021 Ihekweazu et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.
Lymphocyte Antigen 9 as a potential immunotherapeutic target and a new prognostic biomarker for lung adenocarcinoma
Authors: Deng Kun , Xu Zhanyu , Yuan Liqiang , Qin Fanglu , Zheng Zhiwen , Huang Liuliu , Jiang Wei , Qin Junqi , Sun Yu , Zheng Tiaozhan , Zheng Liping , Li Shikang 
Published: March 2022

Abstract
BackgroundLymphocyte Antigen 9 (LY9) participates in the development of several tumors and diseases. However, it has not been reported yet in lung adenocarcinoma (LUAD). MethodsFirst, we retrieved the pan-cancer transcriptomic and clinical data from the UCSC official website and performed LY9 differential expression analysis. Then, we used the Kaplan-Meier Plotter and GEPIA databases to perform prognostic analysis of LY9 expression in pan-cancer. Additionally, we conducted correlation analysis of LY9 expression in LUAD with immune cell infiltration using the TIMER database and the CIBERSOFT algorithm, and with immune checkpoints using the GEPIA database. Also, we constructed a potential ceRNA network for LY9. Furthermore, we explored LY9-related pathways by Gene Set Enrichment Analysis. Finally, we collected LUAD tissues for Quantitative Real-time PCR to verify the expression of LY9, CD8, and CD4 and calculated the correlation between them. ResultsResults showed that LY9 was highly expressed in various tumors, including LUAD. Besides, patients with high LY9 expression presented longer overall survival and more multiple lymphocyte infiltrations. The expression of LY9 in LUAD promotes the infiltration of multiple immune cells, while significantly and positively correlating with immune checkpoints. The functional enrichment analysis indicated that LY9 was involved in multiple immune-related pathways and non-small cell lung cancer. Moreover, a ceRNA regulatory network of LINC00943-hsa-miR-141-3p-LY9 might be involved. Finally, the qRT-PCR results verified that the expression of LY9 in LUAD has a strong and positive correlation with CD4 and CD8 T cells. ConclusionSo LY9 can be a new prognostic biomarker and immunotherapeutic target for LUAD.
Google Trends as a Predictive Tool for COVID-19 Vaccinations in Italy: Retrospective Infodemiological Analysis
Authors: Rovetta Alessandro 
Published: March 2022

Background
Google Trends is an infoveillance tool widely used by the scientific community to investigate different user behaviors related to COVID-19. However, several limitations regarding its adoption are reported in the literature.

Objective
This paper aims to provide an effective and efficient approach to investigating vaccine adherence against COVID-19 via Google Trends.

Methods
Through the cross-correlational analysis of well-targeted hypotheses, we investigate the predictive capacity of web searches related to COVID-19 toward vaccinations in Italy from November 2020 to November 2021. The keyword “vaccine reservation” query (VRQ) was chosen as it reflects a real intention of being vaccinated (V). Furthermore, the impact of the second most read Italian newspaper (vaccine-related headlines [VRH]) on vaccine-related web searches was investigated to evaluate the role of the mass media as a confounding factor. Fisher r-to-z transformation (z) and percentage difference (δ) were used to compare Spearman coefficients. A regression model V=f(VRH, VRQ) was built to validate the results found. The Holm-Bonferroni correction was adopted (P*). SEs are reported.

Results
Simple and generic keywords are more likely to identify the actual web interest in COVID-19 vaccines than specific and elaborated keywords. Cross-correlations between VRQ and V were very strong and significant (min r²=0.460, P*<.001, lag 0 weeks; max r²=0.903, P*<.001, lag 6 weeks). The remaining cross-correlations have been markedly lower (δ>55.8%; z>5.8; P*<.001). The regression model confirmed the greater significance of VRQ versus VRH (P*<.001 vs P=.03, P*=.29).

Conclusions
This research provides preliminary evidence in favor of using Google Trends as a surveillance and prediction tool for vaccine adherence against COVID-19 in Italy. Further research is needed to establish the appropriate use and limits of Google Trends for vaccination tracking. However, these findings prove that the search for suitable keywords is a fundamental step to reduce confounding factors. Additionally, targeting hypotheses helps diminish the likelihood of spurious correlations. It is recommended that Google Trends be leveraged as a complementary infoveillance tool by government agencies to monitor and predict vaccine adherence in this and future crises by following the methods proposed in this paper.
Evaluating User Feedback for an Artificial Intelligence–Enabled, Cognitive Behavioral Therapy–Based Mental Health App (Wysa): Qualitative Thematic Analysis
Authors: Malik Tanya , Ambrose Adrian Jacques , Sinha Chaitali 
Published: March 2022

Background
Digital mental health apps are rapidly becoming a common source of accessible support across the world, but their effectiveness is often influenced by limited helpfulness and engagement.

Objective
This study’s primary objective was to analyze feedback content to understand users’ experiences with engaging with a digital mental health app. As a secondary objective, an exploratory analysis captured the types of mental health app users.

Methods
This study utilized a user-led approach to understanding factors for engagement and helpfulness in digital mental health by analyzing feedback (n=7929) reported on Google Play Store about Wysa, a mental health app (1-year period). The analysis of keywords in the user feedback categorized and evaluated the reported user experience into the core domains of acceptability, usability, usefulness, and integration. The study also captured key deficits and strengths of the app and explored salient characteristics of the types of users who benefit from accessible digital mental health support.

Results
The analysis of user feedback found the app to be overwhelmingly positively reviewed (6700/7929, 84.50% 5-star rating). The themes of engaging exercises, interactive interface, and artificial intelligence (AI) conversational ability indicated the acceptability of the app, while the nonjudgmentality and ease of conversation highlighted its usability. The app’s usefulness was portrayed by themes such as improvement in mental health, convenient access, and cognitive restructuring exercises. Themes of privacy and confidentiality underscored users’ preference for the integrated aspects of the app. Further analysis revealed 4 predominant types of individuals who shared app feedback on the store.

Conclusions
Users reported therapeutic elements of a comfortable, safe, and supportive environment through using the digital mental health app. Digital mental health apps may expand mental health access to those unable to access traditional forms of mental health support and treatments.
Interdisciplinary Collaborations in Digital Health Research: Mixed Methods Case Study
Authors: Krause-Jüttler Grit , Weitz Jürgen , Bork Ulrich 
Published: March 2022

BackgroundDigital innovations in medicine are disruptive technologies that can change the way diagnostic procedures and treatments are delivered. Such innovations are typically designed in teams with different disciplinary backgrounds. This paper concentrates on 2 interdisciplinary research teams with 20 members from the medicine and engineering sciences working jointly on digital health solutions.ObjectiveThe aim of this paper was to identify factors on the individual, team, and organizational levels that influence the implementation of interdisciplinary research projects elaborating on digital applications for medicine and, based on the results, to draw conclusions for the proactive design of the interdisciplinary research process to make these projects successful.MethodsTo achieve this aim, 2 interdisciplinary research teams were observed, and a small case study (response rate: 15/20, 75%) was conducted using a web-based questionnaire containing both closed and open self-report questions. The Spearman rank correlation coefficient was calculated to analyze the quantitative data. The answers to the open-ended questions were subjected to qualitative content analysis.ResultsWith regard to the interdisciplinary research projects investigated, the influencing factors of the three levels presented (individual, team, and organization) have proven to be relevant for interdisciplinary research cooperation.ConclusionsWith regard to recommendations for the future design of interdisciplinary cooperation, management aspects are addressed, that is, the installation of a coordinator, systematic definition of goals, required resources, and necessary efforts on the part of the involved interdisciplinary research partners. As only small groups were investigated, further research in this field is necessary to derive more general recommendations for interdisciplinary research teams.Trial RegistrationGerman Clinical Trials Register, DRKS00023909, https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00023909 ; German Clinical Trials Register, DRKS00025077, https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00025077
Health Related Quality of Life in Children with Sickle Cell Disease: A Concept Analysis
Authors: Al Nasiri Yusra , Al Mawali Adhra Hilal 
Published: March 2022

Objective The purpose of this concept analysis is to examine the health-related quality of life in children with sickle cell disease.
Methods Meleisâ€™s (Theoretical Nursing: Development and Process. 5th Ed.; J. B. Lippincott, Williams & Wilkins, Philadelphia, 2012) concept analysis methodology was followed for analyzing health related quality of life concept. This includes defining the concept, clarifying ambiguities, describing the critical attributes, identifying the observable and measurable empirical referent, delineating the antecedents, the consequences, and modeling to illustrate the concept in its entirety. Articles focusing on quality of life, health-related quality of life (HRQOL) in children with sickle cell disease (SCD) were examined.
Results The concept appears well developed and the internal characteristic of HRQOL is delineated. To ensure that its characteristics maintained contextual relevance, a concept called â€˜fine tuneâ€™ should be done. Since HRQOL concept is a multidimensional concept, a factor analysis test may be needed to explore the dimensionality and the structure of its meaning. Also, internal consistency reliability needs to be done to assess the items independence of one another.
Conclusion Successful patient outcomes is an important goal for nursing and it is critical to health care decision making for practical, ethical, and financial. The analysis of HRQOL concept provided more clarity to the concept definition and also to the underlying outcome measures. Naming the variables of the concepts clearly facilitates comparing and contrasting the healthcare interventions on various patientsâ€™ outcomes. In addition, by examining the concept in children with SCD, pediatric nurses become more cognizant of the conceptâ€™s meaning that would easily facilitate the understanding of the childrenâ€™s and their parentsâ€™ perception of HRQOL.
The incidence and mortality rate of cervix cancer in Iran from 1990 to 2016: A systematic review and meta-analysis Running title: Cervix cancer in Iran
Authors: Riahi Shirin , Mokhtari Ali Mohammad , Vali Mouhebat , Abdzadeh Elham , Mohseni Shokrollah , Salehiniya Hamid , Hassanipour Soheil 
Published: March 2022

Objective: Cervix Cancer (CC) is one of the major health problems among Iranian women and elsewhere around the world. Considering the importance of this cancer, the present study was conducted to determine the age-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR) of CC in Iran.
Methods: A search was conducted using international databases (Medline/PubMed, ProQuest, Scopus, Embase and ISI/ web of knowledge), and national databases (Scientific Information Database, MagIran, IranMedex, and IranDoc). This systematic review was carried out according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) check list in 2018. Thereafter, Persian and English language papers referring to the ASIR and ASMR of CC in Iran were included. Data were independently extracted by two reviewers. The Joanna Briggs checklist was carried out to evaluate the quality of studies.
Result: A total of 522 papers were obtained in the initial search of the databases, and 25 articles were included to the review by further refinement and screening. Based on the random-effect model, the ASIR and ASMR of CC in Iran was 2.14 per 100000, 95% CI (1.89 to 2.38) and 0.93 per 100000, 95% CI (0.81 to 1.05), respectively.
Conclusion: The incidence and mortality of CC in Iran was lower than other parts of the world. It should be noted that because of the high heterogeneity of the results of this study, we must judge with caution regarding the results.
Evaluation of Nigella Sativa and Honey Combination for Treatment of kidney Stone: a Randomized, Placebo Controlled Clinical Trial
Authors: Moghimipour Eskandar , Ghorbani Ali , Malayeri Alireza , Siahpoosh Amir , Khodadoost Mahmood , Rajaeipour Mehdi , Ahmadi Angali Kambiz , Zaheri Abdehvand Laleh 
Published: March 2022

Objectives: The aim of this study was to evaluate the efficacy of N. sativa with honey on treatment of Kidney stone.
Methods: A clinical trial was conducted on 42 patients who were referred to the urology clinic of Ganjavian Hospital, Dezful, Iran and were identified by a sonographist that they had kidney stones smaller than 6 mm, they were without hydronephrosis, and did not require medication. They were randomly assigned to control (n= 20) and treatment (n= 22) groups. 8 grams of NS and honey combination with one glass of warm water were given daily to the treatment group for one month. The control group did not receive medication. Both groups drank 6-8 glasses of water daily.
Results: The rate of stone expulsion in the treatment group was significantly higher than the control group (P value = 0.0001).
Conclusion: According to our results, it seems that NS with honey may have some beneficial effects in treatment of kidney Stone.