bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of synbiotic supplementation on enteral feeding tolerance, protein homeostasis, and muscle wasting of critically ill adult patients: a randomized controlled trial
Authors: Seifi Najmeh , Rezvani Reza , Sedaghat Alireza , Nematy Mohsen , Khadem-Rezaiyan Majid , Safarian Mohammad 
Published: October 2022

Abstract
Background
Enteral feeding intolerance, energy-protein malnutrition, and muscle wasting are common conditions in the critical care setting. The primary aim of this study was to investigate the effect of synbiotic supplementation on enteral feed volume, energy and protein homeostasis, and muscle mass maintenance in critically ill adult patients.

Methods
A consecutive of 42 patients admitted to the Edalatian Medical ICU, requiring enteral nutrition (EN), were prospectively randomized to receive the synbiotic capsule (containing a combination of Lactobacillus, Bifidobacterium, Streptococcus, and fructooligosaccharides) or placebo (21 patients in each group) for a maximum of 14 days. Enteral intolerance and energy homeostasis were evaluated on a daily basis. Nitrogen balance and 24-h urine creatinine excretion were recorded on days 1 and 14. Mid-arm circumference was recorded every 3 days.

Results
Mean EN volume, energy, and protein intake per day were 962.5 ± 533.82 ml, 770 ± 427.05 kcal, and 38.5 ± 21.35 g (fourth day) vs. 590 ± 321.1 ml, 472 ± 256.81 kcal, and 23.6 ± 12.84 g (first day) in the synbiotic group (p < 0.05). Changes in the placebo group were not statistically significant. On day 1, nitrogen balance (NB) was − 19.84 ± 8.03 in the synbiotic vs. − 10.99 ± 9.12 in the placebo group (p = 0.003). On day 14, NB was − 14.18 ± 13.05 in the synbiotic and − 9.59 ± 7.71 in the placebo group (p = 0.41). Mid-arm circumference (MAC), 24-h urine creatinine, and creatinine-height index were almost steady in the synbiotic group, while they decreased in the placebo group.

Conclusion
Overall, it can be concluded that enteral nutrition supplemented with synbiotics has no statistically significant effect on energy and protein homeostasis and muscle mass maintenance of critically ill patients on day 14, but it can increase enteral feed volume and energy and protein intake during the first 4 days of ICU admission.

Trial registration
The trial protocol has been approved in Iranian Registry of Clinical Trials on March 17, 2019. The registration reference is IRCT20190227042857N1.
The different faces of metastatic melanoma in the gastrointestinal tract
Authors: Serrao Eva Mendes , Costa Ana Maria , Ferreira Sergio , McMorran Victoria , Cargill Emma , Hough Caroline , Shaw Ashley S. , O’Carrigan Brent , Parkinson Christine A. , Corrie Pippa G. , Sadler Timothy J. 
Published: October 2022

AbstractMelanoma is the most aggressive form of skin cancer, with tendency to spread to any organ of the human body, including the gastrointestinal tract (GIT). The diagnosis of metastases to the GIT can be difficult, as they may be clinically silent for somewhile and may occur years after the initial melanoma diagnosis. CT imaging remains the standard modality for staging and surveillance of melanoma patients, and in most cases, it will be the first imaging modality to identify GIT lesions. However, interpretation of CT studies in patients with melanoma can be challenging as lesions may be subtle and random in distribution, as well as sometimes mimicking other conditions. Even so, early diagnosis of GIT metastases is critical to avoid emergency hospitalisations, whilst surgical intervention can be curative in some cases. In this review, we illustrate the various imaging presentations of melanoma metastases within the GIT, discuss the clinical aspects and offer advice on investigation and management. We offer tips intended to aid radiologists in their diagnostic skills and interpretation of melanoma imaging scans.
Diffusion imaging could aid to differentiate between glioma progression and treatment-related abnormalities: a meta-analysis
Authors: van den Elshout Rik , Scheenen Tom W. J. , Driessen Chantal M. L. , Smeenk Robert J. , Meijer Frederick J. A. , Henssen Dylan 
Published: October 2022

Abstract
Background
In a considerable subgroup of glioma patients treated with (chemo) radiation new lesions develop either representing tumor progression (TP) or treatment-related abnormalities (TRA). Quantitative diffusion imaging metrics such as the Apparent Diffusion Coefficient (ADC) and Fractional Anisotropy (FA) have been reported as potential metrics to noninvasively differentiate between these two phenomena. Variability in performance scores of these metrics and absence of a critical overview of the literature contribute to the lack of clinical implementation. This meta-analysis therefore critically reviewed the literature and meta-analyzed the performance scores.

Methods
Systematic searching was carried out in PubMed, EMBASE and The Cochrane Library. Using predefined criteria, papers were reviewed. Diagnostic accuracy values of suitable papers were meta-analyzed quantitatively.

Results
Of 1252 identified papers, 10 ADC papers, totaling 414 patients, and 4 FA papers, with 154 patients were eligible for meta-analysis. Mean ADC values of the patients in the TP/TRA groups were 1.13 × 10−3mm2/s (95% CI 0.912 × 10–3–1.32 × 10−3mm2/s) and 1.38 × 10−3mm2/s (95% CI 1.33 × 10–3–1.45 × 10−3mm2/s, respectively. Mean FA values of TP/TRA was 0.19 (95% CI 0.189–0.194) and 0.14 (95% CI 0.137–0.143) respectively. A significant mean difference between ADC and FA values in TP versus TRA was observed (p = 0.005).

Conclusions
Quantitative ADC and FA values could be useful for distinguishing TP from TRA on a meta-level. Further studies using serial imaging of individual patients are warranted to determine the role of diffusion imaging in glioma patients.
Magnetic resonance imaging patterns of paediatric brain infections: a pictorial review based on the Western Australian experience
Authors: Yang Chi-Wei Robin , Mason Michael , Parizel Paul M. , Warne Richard 
Published: October 2022

AbstractPaediatric brain infections are relatively uncommon, but it is important for radiologists to recognise the disease and provide accurate differential diagnoses. Magnetic resonance imaging (MRI) plays an important role in determining the most likely causative pathogen—either in the setting of an unwell child with acute infectious encephalitis, or in the evaluation of a child for sequela of prior infection. Image analysis can, however, be difficult since a particular pathogen can cause variable MRI findings across different geographic environments, and conversely, a particular appearance on MRI may be caused by a variety of pathogens. This educational review aims to identify some of the key MRI patterns seen in paediatric brain infections and present example cases encountered in Western Australia. Based on (i) the predominant type of signal abnormality (restricted diffusion versus T2 hyperintensity) and (ii) the distribution of signal abnormality throughout the brain, this review presents a framework of six key MRI patterns seen in paediatric brain infections, with an emphasis on acute infectious encephalitis. There is general utility to these MRI patterns—each suggestive of a group of likely diagnostic possibilities which can be calibrated according to institution and local environment. The pattern-based framework of this review can be easily transitioned into daily radiological practice, and we hope it facilitates the formation of accurate differential diagnoses in paediatric brain infections.
ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis
Authors: Wu Baitong , Feng Jiuxing , Guo Jingyi , Wang Jian , Xiu Guanghui , Xu Jiaqi , Ning Ke , Ling Bin , Fu Qingchun , Xu Jun 
Published: October 2022

Abstract
Background
Hepatic fibrosis is a common pathologic stage in chronic liver disease development, which might ultimately lead to liver cirrhosis. Accumulating evidence suggests that adipose-derived stromal cells (ADSCs)-based therapies show excellent therapeutic potential in liver injury disease owing to its superior properties, including tissue repair ability and immunomodulation effect. However, cell-based therapy still limits to several problems, such as engraftment efficiency and immunoreaction, which impede the ADSCs-based therapeutics development. So, ADSCs-derived extracellular vesicles (EVs), especially for exosomes (ADSC-EXO), emerge as a promise cell-free therapeutics to ameliorate liver fibrosis. The effect and underlying mechanisms of ADSC-EXO in liver fibrosis remains blurred.

Methods
Hepatic fibrosis murine model was established by intraperitoneal sequential injecting the diethylnitrosamine (DEN) for two weeks and then carbon tetrachloride (CCl4) for six weeks. Subsequently, hepatic fibrosis mice were administrated with ADSC-EXO (10 μg/g) or PBS through tail vein infusion for three times in two weeks. To evaluate the anti-fibrotic capacity of ADSC-EXO, we detected liver morphology by histopathological examination, ECM deposition by serology test and Sirius Red staining, profibrogenic markers by qRT-PCR assay. LX-2 cells treated with TGF-β (10 ng/ml) for 12 h were conducted for evaluating ADSC-EXO effect on activated hepatic stellate cells (HSCs). RNA-seq was performed for further analysis of the underlying regulatory mechanisms of ADSC-EXO in liver fibrosis.

Results
In this study, we obtained isolated ADSCs, collected and separated ADSCs-derived exosomes. We found that ADSC-EXO treatment could efficiently ameliorate DEN/CCl4-induced hepatic fibrosis by improving mice liver function and lessening hepatic ECM deposition. Moreover, ADSC-EXO intervention could reverse profibrogenic phenotypes both in vivo and in vitro, including HSCs activation depressed and profibrogenic markers inhibition. Additionally, RNA-seq analysis further determined that decreased glutamine synthetase (Glul) of perivenous hepatocytes in hepatic fibrosis mice could be dramatically up-regulated by ADSC-EXO treatment; meanwhile, glutamine and ammonia metabolism-associated key enzyme OAT was up-regulated and GLS2 was down-regulated by ADSC-EXO treatment in mice liver. In addition, glutamine synthetase inhibitor would erase ADSC-EXO therapeutic effect on hepatic fibrosis.

Conclusions
These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease.
A general cardinalized probability hypothesis density filter
Authors: Shen Xinglin , Song Zhiyong , Fan Hongqi , Fu Qiang 
Published: October 2022

AbstractBased on random finite set, the probability hypothesis density (PHD) filter and the cardinalized PHD (CPHD) filter have been proposed for multitarget tracking as they are computational tractable. But the classical PHD and CPHD filter is not applicable when a target generates multiple detections. The general PHD filter was proposed to apply the PHD filter to arbitrary clutter and target measurement process. However, as a filter with better performance than the PHD filter, the CPHD filter for multiple-detection tracking is not proposed except the extended target CPHD filter and the multisensor CPHD filter. In our work, the general CPHD filter, which allows the clutter process and target measurement process to be arbitrary and performs better than the general PHD filter, is proposed. The proposed general CPHD filter is the general form of all kinds of CPHD filters, as well as all kinds of PHD filters and Bernoulli filters. In the simulation, the multiple-detection model of the over-the-horizon radar is used to demonstrate the tracking performance. The simulation results show that the proposed filter improves the accuracy of the state estimates and reduces the variance of the estimated number of targets.
Integration intrapreneurship: implementing innovation in a public healthcare organization
Authors: Moss Perrin , Hartley Nicole , Russell Trevor 
Published: October 2022

Abstract
Aim
As global events impact the way organizations operate and innovate in response to regional, workforce and consumer needs, the concept of intrapreneurism is attracting growing interest from policymakers and executives, particularly within the healthcare sector. The aim of this study was to capture the key learnings from the implementation of a telementoring pilot, to understand how intrapreneurship can embed innovation within an established organization to effect more integrated healthcare.

Purpose
A qualitative approach was used with a phenomenological lens to explore the key learnings of the Project ECHO® (Extension for Community Healthcare Outcomes) pilot implementation to provide an understanding of what the project team’s strategies and tactics were during the process of embedding a new business innovation. The implementation and piloting of Project ECHO®, a telementoring model, in a large-scale public healthcare organization in Queensland, Australia, was investigated as an exemplar of integration intrapreneurship.

Findings
Through an inductive approach, this qualitative study found the implementation of the Project ECHO® pilot had specific dimensions and strategies/tactics which were exemplars of intrapreneurism. The organizational context and workforce characteristics described in this study presented new knowledge of how intrapreneurs implemented an innovation to address fragmentation of healthcare service delivery, professional isolation and instances of low-value care. This research contributes to a better understanding of the strategic and tactical approaches to implementing intrapreneurial innovations within a public healthcare organization, with learnings that can be adapted by intrapreneurs in other contexts.
Novel trends of genome evolution in highly complex tropical sponge microbiomes
Authors: Kelly Joseph B. , Carlson David E. , Low Jun Siong , Thacker Robert W. 
Published: October 2022

AbstractBackgroundTropical members of the sponge genusIrciniapossess highly complex microbiomes that perform a broad spectrum of chemical processes that influence host fitness. Despite the pervasive role of microbiomes inIrciniabiology, it is still unknown how they remain in stable association across tropical species. To address this question, we performed a comparative analysis of the microbiomes of 11Irciniaspecies using whole-metagenomic shotgun sequencing data to investigate three aspects of bacterial symbiont genomes—the redundancy in metabolic pathways across taxa, the evolution of genes involved in pathogenesis, and the nature of selection acting on genes relevant to secondary metabolism.ResultsA total of 424 new, high-quality bacterial metagenome-assembled genomes (MAGs) were produced for 10 CaribbeanIrciniaspecies, which were evaluated alongside 113 publicly available MAGs sourced from the Pacific speciesIrcinia ramosa. Evidence of redundancy was discovered in that the core genes of several primary metabolic pathways could be found in the genomes of multiple bacterial taxa. Across hosts, the metagenomes were depleted in genes relevant to pathogenicity and enriched in eukaryotic-like proteins (ELPs) that likely mimic the hosts’ molecular patterning. Finally, clusters of steroid biosynthesis genes (CSGs), which appear to be under purifying selection and undergo horizontal gene transfer, were found to be a defining feature ofIrciniametagenomes.ConclusionsThese results illustrate patterns of genome evolution within highly complex microbiomes that illuminate how associations with hosts are maintained. The metabolic redundancy within the microbiomes could help buffer the hosts from changes in the ambient chemical and physical regimes and from fluctuations in the population sizes of the individual microbial strains that make up the microbiome. Additionally, the enrichment of ELPs and depletion of LPS and cellular motility genes provide a model for how alternative strategies to virulence can evolve in microbiomes undergoing mixed-mode transmission that do not ultimately result in higher levels of damage (i.e., pathogenicity) to the host. Our last set of results provides evidence that sterol biosynthesis inIrcinia-associated bacteria is widespread and that these molecules are important for the survival of bacteria in highly complexIrciniamicrobiomes.
Multi-technique analysis of pigments on sandstone sculptures: Renaissance re-painting of a Roman relief
Authors: Campbell Louisa , Smith Margaret 
Published: October 2022

Abstract
The Antonine Wall was commissioned by the Roman Emperor Antoninus Pius around 142 CE and stretches for c. 60 km across the central belt of Scotland, marking the Empire’s most north-western frontier. This vanguard research reports on the materials referred to by Antiquarian sources as having been applied during the sixteenth century for the redecoration of an iconic Distance Sculpture that was once embedded into the mural barrier. Portable non-invasive technologies, including pXRF and in-situ microphotography were deployed. These techniques were further supplemented by micro-sampling for SEM/EDS, FTIR–ATR and microscopy of embedded cross-sections. The validity of applying these complementary techniques has been confirmed. They provide a comprehensive account of the polychromy present, including pigments that could have been applied during the Roman period and others that were only available from the fifteenth or sixteenth Centuries. The work has confirmed stratigraphic sequencing of the pigments which will, in due course, permit the digital reconstruction of how this Classical relief sculpture would have been adorned during the Renaissance.
COM-1 and Hongcheon: New monazite reference materials for the microspot analysis of oxygen isotopic composition
Authors: Kim Jeongmin , Park Changkun , Yi Keewook , Lee Shinae , Kim Sook Ju , Jung Min-Ji , Cheong Albert Chang-sik 
Published: October 2022

Abstract
Background
Monazite, a moderately common light rare earth element (LREE) and thorium phosphate mineral, has chemical, age, and isotopic characteristics that are useful in the investigation of the origin and evolution of crustal melts and fluid-﻿rock interactions. Multiple stages of growth and partial recrystallization commonly observed in monazite inevitably require microspot chemical and isotopic analyses, for which well-characterized reference materials are essential to correct instrumental biases. In this study, we introduce new monazite reference materials COM-1 and Hongcheon for the use in the microspot analysis of oxygen isotopic composition.

Findings
COM-1 and Hongcheon were derived from a late Mesoproterozoic (~ 1080 Ma) pegmatite dyke in Colorado, USA, and a Late Triassic (~ 230 Ma) carbonatite-hosted REE ore in central Korea, respectively. The COM-1 monazite has much higher levels of Th (8.77 ± 0.56 wt.%), Si (0.82 ± 0.07 wt.%) and lower REE contents (total REE = 49.5 ± 1.2 wt.%) than does the Hongcheon monazite (Th, 0.23 ± 0.11 wt.%; Si, < 0.1 wt.%; total REE, 59.9 ± 0.7 wt.%). Their oxygen isotopic compositions (δ18OVSMOW) were determined by gas-source mass spectrometry with laser fluorination (COM-1, 6.67 ± 0.08‰; Hongcheon-1, 6.60 ± 0.02‰; Hongcheon-2, 6.08 ± 0.07‰). Oxygen isotope measurements performed by a Cameca IMS1300-HR3 ion probe showed a strong linear dependence (R2 = 0.99) of the instrumental mass fractionation on the total REE contents.

Conclusions
We characterized chemical and oxygen isotopic compositions of COM-1 and Hongcheon monazites. Their internal homogeneity in oxygen isotopic composition and chemical difference provide an efficient tool for calibrating instrumental mass fractionation occurring during secondary ion mass spectrometry analyses.
An effective approach for accurate estimation of VLBI–GNSS local-tie vectors
Authors: Matsumoto Saho , Ueshiba Haruka , Nakakuki Tomokazu , Takagi Yu , Hayashi Kyonosuke , Yutsudo Toru , Mori Katsuhiro , Sato Yudai , Kobayashi Tomokazu 
Published: October 2022

AbstractThe local-tie vectors, which connect coordinate frames of different space geodetic techniques, are indispensable for the construction of the International Terrestrial Reference Frame (ITRF). To obtain the local-tie vector connecting very long baseline interferometry (VLBI) sites with high measurement accuracy, it is crucial to accurately determine the antenna invariant point (IVP), which does not change its position under any tracking conditions. In the 2018 co-location survey at Ishioka station, we employed two methods to determine the IVP; “inside” and “outside” methods. We observed a target mirror from inside or outside of the antenna and derived trajectories of the target used for estimation of the rotation axes. Both the methods successfully estimated the IVPs with the measurement error of less than 1 mm, meeting the requirement of measurement accuracy by the International Earth Rotation and Reference Systems Service (IERS). The striking point is that the difference between the IVP positions was less than 1 mm, suggesting that both the methods could determine almost the same position independently. While they both can determine the IVPs with high measurement accuracy, it should be noted that the inside method substantially improved the operational efficiency. For the outside method, we had to repeat the target observations from four or more pillars around the VLBI antenna, with the reinstallation of a total station (TS) if needed. In contrast, for the inside method, we can observe the target from one place inside the antenna in a short time with only one TS no matter where the mirror is attached in the azimuth cabin. We concluded that the inside method is an effective and practical approach to accurately estimate the IVP.
Graphical Abstract
Construction of Web-GIS for integrating geophysical survey data with geotechnical information in the San’in region, southwest Japan
Authors: Nishimura Isamu , Noguchi Tatsuya , Kagawa Takao 
Published: October 2022

AbstractConstructing geotechnical information database to collect information such as geophysical survey results and borehole data and then sharing it among researchers and engineers will be useful for developing research on the subsurface structure and the prevention of disasters such as earthquakes and landslides. The geotechnical information includes analysis results based on geophysical surveys, seismic observations, and borehole data. This database can be visually displayed on a map using a Geographic Information System (GIS). The existing analysis results can be checked consecutively. This will allow us to consider new observation plans and to improve the efficiency and accuracy of the subsurface structure model analysis. Therefore, in this study, a database of geotechnical information was developed for the San’in, Japan region. The San’in, Japan region is the western part of Honshu on the Sea of Japan side and includes Tottori and Shimane prefectures. The database of geotechnical information includes the results of microtremor and gravity survey, estimation of the subsurface structure based on seismic records, and borehole data in Tottori and Shimane prefectures. We gather high dense survey points from multiple references in the San’in region, Japan, such that the average space intervals of single station microtremor, microtremor array, gravity survey, and borehole were around 0.1–1, 1–5, 1, and 0.1–1 km, respectively. Furthermore, the corresponding sites of each survey type were conducted over 6000, over 280, over 7500, and over 3700, respectively. In addition, we developed a system to display the database on a map in a web browser (Web-GIS). GIS, Leaflet, a JavaScript library, were used to display the database of geotechnical information using the Geospatial Information Authority of Japan (GSI) tiled map as the base map. The developed database on the GIS system will be a useful tool that can be used by researchers, engineers, and other stakeholders in the future.
Graphical Abstract