bluuebunny/crossref_metadata_2025_split huggingface dataset:
Existence of two solutions for nonhomoge- neous Klein-Gordon equation with sign-changing potential coupled with Born- Infeld theory
Authors: Wang Lixia , Zhang Dong , Zhao Pingping , Xiong Chunlian 
Published: October 2022

Abstract
In this paper, we study the following nonhomogeneous Klein-Gordon equation with Born-Infeld theory −∆u + λV (x)u − K(x)(2ω + φ)φu = f (x, u) + h(x), x ∈ R 3 , ∆φ + β∆4φ = 4πK(x)(ω + φ)u 2 , x ∈ R 3 , where ω > 0 is a constant, λ > 0 is a parameter and 4φ = div(||φ| 2 φ). Under some suitable assumptions on V, K, f and h, the existence of multiple solutions is proved by using the Linking theorem and the Ekeland’s variational principle in critical point theory. Especially, the potential V is allowed to be sign-changing.
Mathematics Subject Classification (2010). Primary 35B33; Secondary 35J65.
Decellularized placental sponge as an excellent carrier for human mesenchymal stem cells and management of full-thickness skin wounds: an in vitro and in vivo study
Authors: Alizadeh Sanaz , Mahboobi Leila , Nasiri Modara , Khosrowpour Zahra , Khosravimelal Sadjad , Asgari Fatemeh , Gholipour-Malekabadi Mahdieh , Razavi-Toosi Seyyed Mohammad Taghi , Chauhan Narendra Pal Singh , Ghobadi Faezeh , Gholipourmalekabadi Mazaher 
Published: October 2022

AbstractSkin injuries lead to a large burden of morbidity. Although numerous clinical and scientific strategies have been investigated to repair injured skin, optimal regeneration therapy still poses a considerable obstacle. To address this challenge, the decellularized extracellular matrix-based scaffolds recellularized with stem cells offer significant advancements in skin regeneration and wound healing. Herein, a decellularized human placental sponge (DPS) was fabricated using the decellularization and freeze-drying technique, and then re-cellularized with human adipose-derived mesenchymal cells (MSCs). The biological and biomechanical properties and skin full-thickness wound healing capacity of the stem cells-DPS constructs were investigatedin vitroandin vivo. The DPS exhibited a uniform three-dimensional microstructure with an interconnected pore network, 89.21% porosity, a low degradation rate, and good mechanical properties. The DPS and MSCs-DPS constructs were implanted in skin full-thickness wound models in mice. An accelerated wound healing was observed in the wounds implanted with MSCs-DPS construct when compared to DPS and control (wounds with no treatment) during 7 and 21 days post-implantation follow-up. In the MSCs-DPS group, the wound was completely re-epithelialized, the epidermis layer was properly organized, and the dermis and epidermis' bilayer structures were restored after 7 days. Our findings suggest DPS is an excellent carrier for MSCs culture and delivery to skin wounds and now promises to proceed with clinical evaluations.
Differential impacts of informal mutual versus informal individual saving mechanisms on food insecurity in Kenya: Is risk preference a factor?
Authors: Chigusiwa Lloyd , Kairiza Terrence 
Published: October 2022

Abstract

Informal mutual and informal individual saving mechanisms have the potential to facilitate consumption smoothing thereby abridging transitory food insecurity and concomitantly household employment of negative consumption coping strategies. Notwithstanding, the potency of Informal mutual and informal individual saving mechanisms in alleviating transitory food insecurity, individual holding of such saving mechanisms is likely to be influenced by their preference of risk among other factors. This study examined the interplay of preference for risk, Informal mutual and informal individual saving mechanisms and food security on the basis of publicly available data from the 2021 Kenya FinAccess survey. We employ the propensity score matching approach to estimate the effects of preference for risk on the household propensity to hold either informal mutual or, informal individual saving mechanisms and the impact thereof on food security. Our study offers three major findings. First, a preference for risk increases the probability of holding informal mutual saving mechanisms but is not relevant in the holding of informal individual saving mechanisms. Second, we find that informal savings increase household food security. Finally, informal mutual saving mechanisms are more efficient in increasing household food security than informal individual saving mechanisms.
Existence Study of Semilinear Fractional Differential Inclusions for Multi-term Problem
Authors: BENSAYAH Abdallah , HADJADJ Elhabib , TELLAB Brahim , MEFTAH Safia 
Published: October 2022

Abstract
In this paper, we study the existence of solutions for semilinear fractional dierential inclusion multi-term problem in a more general form. A xed point strategy is used to establish existence of solutions, namely Leray-Schauder xed point alternative for set-valued maps. Two cases are considered convexity and non convexity of set valued function. Illustrative examples are provided at the end of our theorems to ensure the eectiveness of our theoretical results.
Biotransformation and detoxification of saxitoxin by Bacillus flexus in batch experiments
Authors: Mohamed Zakaria A , Mostafa Yasser , Alamri Saad , Hashem Mohamed , Alrumman Sulaiman 
Published: October 2022

Abstract

Saxitoxins (STXs) are carbamate alkaloid neurotoxins produced by some species of cyanobacteria. They are water soluble and relatively stable the natural environment, and thereby represent a risk to animal and human health through a long-time exposure. STXs cannot be sufficiently removed by conventional water treatment methods. Therefore, this study investigates the potential STX biodegradation and detoxification by bacteria as a promising method for toxin removal. STX biodegradation experiments were conducted using Bacillus flexus SSZ01 strain in batch cultures. The results revealed that SSZ01 strain grew well and rapidly detoxified STX, with no lag phase observed. STX detoxification by SSZ01 strain was initial-toxin-concentration–dependent. The highest biotransformation rate (10µg STX L-1 day-1) was obtained at the highest initial toxin concentrations (50µg L-1) and the lowest (0.06µg STX L-1 day-1) was recorded at the lowest initial concentration (0.5µg L-1). STX biotransformation rate increased with temperature, with highest occurred at 30 ºC. This rate was also influenced by pH, with highest obtained at pH8 and lowest at higher and lower pH values. HPLC chromatograms showed that STX biotransformation peak is corresponding to the least STX analogue (disulfated sulfocarbamoyl-C1 variant). The Artemia-based toxicity assay revealed that this biotransformation byproduct was nontoxic. This suggests the potential application of this bacterial strain in slow sand filters for cyanotoxin removal in water treatment plants. Being nontoxic, this byproduct needs to be assayed for its therapeutic effects towards neurodegenerative diseases.
On stuttering generalized Yule distribution: properties and applications
Authors: Kumar C Satheesh , S Harisankar 
Published: October 2022

Abstract
Kumar and Harisankar (Commun.Statist.-Theor.Meth., 2020) obtain a generalized version of Yule distribution through the name ‘doubly generalized Yule distribution(DGYD)’ and indicated several applications of the distribution. Through the present article we attempt to develop an order k version of the DGYD and discuss some of its important properties such as mean, variance, expressions for its probability generating function (p.g.f) and recursion formulae for its probabilities, raw moments and factorial moments. Further we attempted the estimation of the parameters of this model by the method of maximum likelihood. The distribution has been fitted to some real life data sets for illustrating its practical relevance. The likelihood ratio test procedure is applied for examining the significance of the parameters and a simulation study is conducted for evaluating the performances of the maximum likelihood estimators of the parameters of the DGYD.
Classification code: Classification code:60E05;62E15
Crystallization rate model of tunnel drainage pipes in karst areas
Authors: Wang Yongdong , Liu Kai , Wang Jie , Qi Chufan , Chen Yuanyuan , Shi Chen , Du Pengxin , Zhou Tianyue 
Published: October 2022

Abstract
The crystallization blockage of the tunnel drainage pipes in karst areas often threatens the normal construction of tunnels and affects operation of drainage systems. Based on basic theory of CaCO3 crystallization, this study analyses the law of the crystalline scale formation rate of tunnel drainage pipes in karst areas through three mass transfer mechanisms: convective mass transfer, molecular diffusion and wall ion reactions, obtains the calculation model of crystalline scale formation rate of drainage pipes, and verifies model by simulating crystalline scale formation tests of tunnel drainage pipes. The results show that factors such as the flow rate of karst water, the inner diameters of tunnel drainage pipes, the molecular diffusion coefficient, the dynamic viscosity of karst water, the molecular diffusion coefficient of calcium carbonate, the temperature of karst water, and the slopes of tunnel drainage pipes have certain influences on the crystallization of the tunnel drainage pipes in karst areas, and they promote or inhibit the formation of scale layers on the inner walls of the tunnel drainage pipes in karst areas by affecting the efficiency of convective mass transfer, molecular diffusion and wall ion reactions; under different test conditions, the average relative errors between the calculated results of the crystalline scale formation rate of drainage pipes and those of the pipes in the test group are 9.1%, 13.7%, 14.2% and 16.1% respectively. Considering the scouring effect of water flow on crystalline scale layers, although there are certain errors in the results, this does not affect the overall results
Extension of CODAS Method Under Cubic Pythagorean fuzzy set for Multi-Criteria Decision Making Problems
Authors: Rahim Muhammad 
Published: October 2022

Abstract
Multi-criteria decision-making (MCDM) approaches are effective and reliable to solve problems with uncertain conditions. The Cubic Pythagorean fuzzy set (CPFS) is the newest model of fuzzy set theory. The aim of this article is to develop cubic Pythagorean fuzzy Combinative Distance-based assessment (PCF-CODAS) by combining CODAS with CPFS, to solve MCDM problems. This method employs the Euclidean distance (ℰ𝒟̅̅̅̅) as the major measure and Taxicab distance (𝒯𝒟̅̅̅̅) as the secondary measure to determine the desirability of the alternative. These distances are calculated with the negative-ideal solution. Furthermore, an example is provided to assess the practicality of the proposed methodology. We also provided a comprehensive sensitivity study to test the CPF-CODAS results and compare them with some existing MCDM methods. These evaluations reveal that the proposed methodology is efficient and the results are stable.
Evaluation of the effect of Artemisia Annua L. and Moringa Oleifera Lam. on CD4 count and viral load among PLWH on HAART at Mbarara Regional Referral Hospital: A Double-Blind Randomized Controlled Clinical Trial
Authors: Twinomujuni Silvano S. , Atukunda Esther C , Mukonzo Jackson K. , Nicholas Musinguzi , Roelofsen Felicitas , Ogwang Patrick E. 
Published: October 2022

Abstract
Background
Initiation of HAART among people living with HIV (PLWH) having a CD4 count ≤ 350cells/µl, produces poor immunological recovery, putting them at a high risk of opportunistic infections. Artemisia annua and Moringa oleifera are among the herbs commonly consumed by PLWH on HAART to boost their immunity, but their clinical benefits and potential interactions with ARVs remain unknown. This study investigated the effect of A.annua and M.oleifera on CD4 count, viral load, and other clinical and haematological indices among PLWH on HAART at an HIV clinic in Uganda.
Methods
282 HIV-positive participants on HAART with a CD4 count ≤ 350cells/µl were randomized in a double-blind clinical trial to receive daily, in addition to their routine standard of care; 1) A.annua leaf powder, 2) A.annua plus M.oleifera, and 3) routine standard of care only. Our primary outcome was change in the CD4 count at 12 months. Secondary outcomes included change in viral load, complete blood count, renal function tests, liver function tests, ARV plasma levels, and quality of life (QoL). Participants were followed up for a year and outcomes were measured at baseline, 6 and 12 months.
Results
At 12 months of patient follow-up, administration of A.annua + M.orifera plus routine standard of care produced an absolute mean CD4 increment of 105.06 cells/µl, (P < 0.001), while administration of A.annua plus routine standard of care registered an absolute mean CD4 increment of 60.84 cells/µl, (P = 0.001) compared to the control group. The viral load reduced significantly (P = 0.022) for participants on the A.annua + M.orifera compared to those receiving standard of care only. There were significant differences in White blood cell count (P = 0.03), platelet count (P = 0.025), perceived QoL (P < 001) among participants who received A.annua + M.oleifera compared to those who received standard of care only. There were no significant differences in the other secondary outcomes.
Conclusion
A combination of A.annua and M.oleifera leaf powders taken once a day together with the routine standard of care produced significant improvement in CD4 count, viral load suppression, WBCs, platelets, and quality of life among individuals on HAART.
Evaluation of blood indexes in rats under natural environment of chronic high altitude hypotension and hypoxia
Authors: Yan Chunlong , Tian Dengfeng , Zhang Chenhong , Zhang Qiang , Sun Yanqiu 
Published: October 2022

Abstract
Background
The plateau area has the environmental characteristics of low pressure and hypoxia, and the special geographical environmental characteristics have an impact on multiple systems of the body. The purpose of this study was to explore the changes in blood indicators of rats in a natural environment of low pressure and hypoxia on the plateau.
Methods
Twenty male Sprague Dawley (SD) rats aged 4 weeks were selected and transported to Chengdu area (approximately 450 m above sea level, 10 rats) and Yushu area (approximately 3800 m above sea level,10 rats) in two groups. They were defined as plain group and plateau group, respectively. They were raised to 28 weeks of age, and then transported to the plateau medical laboratory of Qinghai University. Blood index data were measured and the data of the two groups were statistically analyzed.
Results
1. RBC in plateau group was higher than that in plain group, but there was no significant difference between the two groups (P > 0.05),Compared with the plain group, HGB, MCV, MCH, MCHC and RDW in the plateau group were significantly higher (P < 0.05).2. Compared with the plain group, WBC, LYMP, EO, LYMP% and EO% in the plateau group decreased significantly (P < 0.05), and ANC% increased significantly (P < 0.05), The ANC, MONO and BASO in the plateau group were lower than those in the plain group, but the difference was not statistically significant (P > 0.05), The MONO% and BASO% in the plateau group were higher than those in the plain group, and the difference was not statistically significant (P > 0.05). 3. In the platelet index, compared with the plain group, PLT in the plateau group was significantly reduced (P < 0.05), PDW, MRV, P-LCR were significantly increased (P < 0.05), and PCT in the plateau group was lower than that in the plain group, but the difference was not statistically significant (P > 0.05). 4. In blood biochemical indicators, compared with the plain group, AST, TBIL, IBIL, LDH in the plateau group decreased significantly (P < 0.05), CK in the plateau group increased significantly (P < 0.05), ALT, DBIL, Cr, TC in the plateau group decreased, with no statistically significant difference (P > 0.05), and ALT/AST, ALP in the plateau group increased, with no statistically significant difference (P > 0.05).
Conclusion
1. The indexes related to red blood cells, white blood cells, platelets and some biochemical indexes in the blood of rats at high altitude have changed. 2. Under the high altitude low pressure and hypoxia environment, the oxygen carrying capacity of SD rats is improved, the resistance to disease may be reduced, the coagulation and hemostasis functions may be affected, and there is a risk of bleeding. The liver function, renal function, heart function and skeletal muscle energy metabolism may be affected. 3. This study can provide an experimental basis for the research on the pathogenesis of high altitude diseases from the perspective of blood.
Isolation and exploration of potential probiotic attributes of a novel isolate Pedicoccus acidilactici CITKHZ7 obtained from traditional fermented fish paste Hentak
Authors: Basumatary Zircon , Saha Sourav , Barman Kailash Kr. , Chaudhuri Surabhi , Maiti Sucharita Sen , Nayak Prakash Kumar 
Published: October 2022

Abstract
In vitro probiotic and antibacterial activity was demonstrated by a novel isolate CITKHZ7 identified as Pediococcus acidilactici. It exhibited adequate resistance against the severe circumstance of gastrointestinal tract (GI), surviving at low acidic pH (pH 2.0) for 5hr. The initial viable cell population of isolate CITKHZ7 was reduced by 2.84% and 4.48% by artificial gastric juice and simulated intestinal fluid respectively. Enzyme lysozyme (100 mg/ml) and bile salt (0.3%) both reduced vitality by 13.92% and 10.35% within 5hr. The isolate did not show any significant bile salt deconjugation activity. The cell surface hydrophobicity of 45.94% was highest against hydrocarbon chloroform and the isolate cell surface was seen to be electrophilic in nature. In this research study, 51% autoaggregation was observed in the isolate CITKHZ7 within 5hr. Both of these properties are required for attachment to epithelial cells and colonisation of the host. The in-vitro adhesion of the CITKHZ7 was carried out with human epithelial carcinoma cell line Caco-2.
Developmental origins of psycho-cardiometabolic multimorbidity in adolescence and their underlying pathways through methylation markers: A two cohort’s study
Authors: Choudhary Priyanka , Ronkainen Justiina , Carson Jennie , Karhunen Ville , Lin Ashleigh , Melton Phillip E. , Jarvelin Marjo-Riitta , Miettunen Jouko , Huang Rae-Chi , Sebert Sylvain 
Published: October 2022

Abstract
Understanding the biological mechanisms behind multimorbidity patterns in adolescence is important as they may act as intermediary risk factor for long-term health. We aimed to explore relationship between prenatal exposures and adolescent’s psycho-cardiometabolic intermediary traits mediated through epigenetic biomarkers, using structural equation modelling (SEM). We used data from mother-child dyads from pregnancy and adolescents at 16–17 years from two prospective cohorts: Northern Finland Birth Cohort 1986 (NFBC1986) and Raine Study from Australia. Factor analysis was applied to generate two different latent factor structures: a) prenatal exposures and b) adolescence psycho-cardiometabolic intermediary traits. Furthermore, three types of epigenetic biomarkers were included: 1) DNA methylation score for maternal smoking during pregnancy (DNAmMSS), 2) DNAm age estimate PhenoAge and 3) DNAm estimate for telomere length (DNAmTL). We observed similar factor structure was observed between both cohorts yielding three prenatal factors BMI (Body Mass Index), SOP (Socio-Obstetric-Profile) and Lifestyle, and four adolescent factors: Anthropometric, Insulin-Triglycerides, Blood Pressure and Mental health. In the SEM pathways, stronger direct effects of F1prenatal-BMI (NFBC1986 = ß: 0.27; Raine = ß: 0.39) and F2prenatal-SOP (ß: -0.11) factors were observed on adolescent psycho-cardiometabolic multimorbidity. The indirect effect of the prenatal latent factors through epigenetic markers was mediated from DNAmTL and DNAmMSS going through PhenoAge (NFBC1986 = ß: 0.04; Raine = ß: 0.14), consistently in both cohorts (P < 0.001). The present study exemplifies an evidence-based approach validated in two birth cohorts to demonstrate consistent shared influences of prenatal exposures mediated through epigenetic markers in the offspring on their psycho-cardiometabolic multimorbidity in adolescence.
Protective effect of sex steroid hormones on morphological and cellular outcomes after neonatal hypoxia-ischemia: A meta-analysis of preclinical studies
Authors: Durán-Carabali LE , Silva JL Da , Colucci ACM , Netto CA , De Fraga LS 
Published: October 2022

Abstract

Sex steroid hormones play an important role in fetal development, brain functioning and neuronal protection. Growing evidence highlights positive effects of these hormones against brain damages induced by neonatal hypoxia-ischemia (HI). This systematic review and meta-analysis aim to verify the efficacy of sex steroid hormones to prevent HI-induced brain damage in rodent models. The protocol was registered at PROSPERO and a total of 22 articles were included. Moderate to large effects were observed in HI animals treated with sex steroid hormones in reducing cerebral infarction size and cell death, increasing neuronal survival and mitigating neuroinflammatory responses and astrocyte reactivity. A small effect was evidenced for cognitive function, and there was no significant effect for motor function. In summary, published rodent data suggest that sex steroid hormones such as progesterone and 17β estradiol improve morphological and cellular outcomes following neonatal HI. Additional research is paramount to examine neurological function during neonatal HI recovery.
Examining The Levels Of Zenophobia And Global Social Responsibility Of Health Sciences Students: A Cross-Sectional Study İn The Case Of Konya
Authors: KUCUKSEN Kubra , Arat Seyma 
Published: October 2022

Abstract

One of the most important global problems of the century we are living in is the problem of “how to live together despite differences?”. Although geographical boundaries lost their importance with the globalization process, the walls that people created against the “other” continue to exist in a formidable way. In the present study, the relationship between xenophobia and global social responsibility in healthcare professional candidates was investigated. The study also examined the effects of demographic variables, receiving courses on immigration and immigrants, and the presence of international students in their classes on xenophobia and global social responsibility attitude. A total of 354 university students who were studying in the field of healthcare answered the Xenophobia Scale (ZS), the Global Social Responsibility Scale (CSRS), and the questionnaire that consisted of 7 closed-ended questions. As the global social responsibility levels of the students increased, their xenophobia levels decreased. Being together with international students reduced the level of xenophobia. The level of xenophobia of seniors was found to be lower. Also, the level of xenophobia was lower for those who received courses on immigration. Women had a higher level of Global Social Responsibility.