bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introduction
Authors: Keymer Tom 
Published: January 2022

Abstract
‘Introduction’ provides an overview of Jane Austen and her works. Today, Austen is one of the most securely established literary classics in English. One explanation for Austen’s global popularity lies in her capacity to speak directly to readers navigating elaborate social conventions or rule-bound environments. By focusing in most of her novels on heroines who occupy positions of socioeconomic disadvantage in relation to those around them, and on the difficulties presented to them by the assumptions, conventions, and practices of their worlds, Austen converts courtship fiction to purposes more critical than those of mere fantasy or celebration. Indeed, it is hard to read Austen without sensing the satirical charge that animates her fiction throughout. She is not a radical novelist like Mary Wollstonecraft or William Godwin; more interestingly, she is a novelist in whom an implicitly Tory world-view is frequently interrogated or disrupted by destabilizing ironies and irruptions of satirical energy that are no less real for the elegance and wit of their expression.
Behaviourism
Authors: Montero Barbara Gail 
Published: January 2022

Abstract
‘Behaviourism’ looks at the view that mental states—beliefs, desires, emotions, and so forth—are merely sets of behaviours. What is the motivation for and feasibility of the view? Gilbert Ryle criticised Cartesian dualism, which is based on the idea that dualists are making a ‘category mistake’. He put forward his own behaviouristic theory of mind. Behaviourism avoids ‘the problem of other minds’. If the mind is behaviour, it is clear that other people have minds, but if the mind is an inner experience, then the only person who can be certain of having a mind is the person having the experience. Behaviourism has a number of theories relating to intelligence and conceptions of dispositions.
Single Plasma Unit Transfusions in Adults Are Either Unnecessary or Underdosed
Authors: Drake Rosanna , Jackson Bryon P , Murphy Colin H 
Published: January 2022

AbstractObjectivesPrevious studies of blood product use have shown higher inappropriate use of plasma compared with other products. Given typical weight-based dosing of plasma, we hypothesized that single plasma transfusions in adults would either be a nontherapeutic dose or outside clinical guidelines.MethodsA single-center, retrospective review of nonoperative, nonapheresis plasma use was conducted from January 2020 to April 2020. Plasma transfusions were reviewed for compliance with clinical guidelines formulated at our institution as well as national and society guidelines.ResultsDuring the study period, 313 units of plasma were transfused. Of these, 152 (48.6%) were given against institutional or national guidelines, 126 plasma units (40.3%) were transfused as single units, and 187 (59.7%) were given as part of multiple-unit transfusions. All single-unit plasma transfusions during the study period were either underdosed or outside clinical guidelines. Units transfused with an indication of “Other” were significantly more likely to be outside clinical guidelines.ConclusionsNonoperative, nonapheresis plasma use is often outside clinical guidelines. Single-unit plasma transfusions in adults are a potential target for patient blood management programs seeking to minimize unnecessary plasma use.
Development and implementation of a pharmacist-led telehealth medication management program for veterans receiving oral antineoplastic therapies through the MISSION Act
Authors: Passey Deborah , Healy Regan , Qualls Joshua , Hamilton Clayton J , Tilley Elizabeth , Burningham Zach , Sauer Brian , Halwani Ahmad 
Published: January 2022

Abstract

Purpose
Veterans prescribed oral antineoplastic therapies (OATs) by community providers outside the Veterans Health Administration (VA) may lack access to comprehensive medication management. To address this, our multidisciplinary team developed and implemented a pharmacist-led telehealth medication management program for veterans prescribed OATs by community providers.

Summary
The program exclusively uses telehealth to connect veterans with a dedicated board-certified clinical oncology pharmacist who provides comprehensive medication management. The program is based on established pharmacy models found in the research literature. We developed a standard operating procedure, communication templates, patient education materials, and a suite of health information technology tools to help streamline pharmacy processes. The Consolidated Framework for Implementation Research was used to design implementation strategies to promote the adoption of the program. In the first year, 64 veterans from 3 VA medical centers were enrolled in the program. The oncology clinical pharmacist performed 342 encounters and 101 interventions. The program saved an estimated $200,724 in medication-related costs. The veterans we surveyed reported high levels of satisfaction with the pharmacy services provided by the program.

Conclusion
The delivery of comprehensive medication management through telehealth is feasible from a healthcare system perspective and beneficial for patients. The board-certified oncology clinical pharmacist provided remote pharmacy services to Veterans across three sites in a large and rural service area for the VA. The program realized several benefits, including positive clinical outcomes, high levels of patient satisfaction, and cost savings on medication-related costs.
The Black Situation: Notes on Black Critical Theory Now
Authors: Reed Anthony 
Published: January 2022

Abstract
This essay argues that what some critics have dubbed an ontological turn in Black critical theory—the tendency to theorize racial antagonisms in general and antiblackness in particular as a function of the “being” of the West—reflects a more general pessimism endemic to our historical moment. That pessimism has been catalyzed by the collapse of meaningful alternatives in the postcolonial, post-communist moment, which results in occluded or obscured pathways to collective striving and worldmaking. One important response to the ontological turn has seen critics turn to Black culture to highlight peculiar modes of subjectivity shaped, but not defined by, ongoing racial antagonism. As Black particularity in this account remains implicit or intuitive, insofar as Black particularity remains a given rather than theorized, this tendency proves to be the other’s flipside rather than alternative. This essay concludes by proposing that rather than studying culture to understand Black life, one study Black life to understand cultural production. The titular “Black situation” is its term for historical materialist analysis attuned to the complex modalities through which racial antagonism appears in daily life as well as the compulsions that impede sovereign individual agency.
For the Record: Questioning Transcription Processes in Legal Contexts
Authors: Richardson Emma , Haworth Kate , Deamer Felicity 
Published: January 2022

Abstract
Written records of spoken interaction are typically assumed to be adequate for the purpose they serve, often receiving minimal scrutiny from the institutions which consume them. In this article, we scrutinize the current practices of capturing spoken interaction in legal contexts in England and Wales, and highlight some of the often serious legal consequences that result. We ask five questions of record keeping in legal settings: (i) Is the record produced an accurate representation of the spoken interaction?; (ii) Do lay and PPs have ownership? Answered by giving careful thought to the rights they may or may not have to their data; (iii) Who has agency, who’s ‘voice’ is represented in the recorded account?; (iv) Then, we ask how usable the record is; and (v) How resource efficient it is to produce and use. By asking these questions, we make visible the underlying assumptions about transcription adequacy—in doing so, we acknowledge and enable reflection on the process of capturing spoken interaction. We envisage this model to be applicable to a range of institutional settings.
Mouse Cre drivers: tools for studying disorders of the human female neuroendocrine-reproductive axis
Authors: Chemerinski Anat , Liu Chang , Morelli Sara S , Babwah Andy V , Douglas Nataki C 
Published: January 2022

AbstractBenign disorders of the human female reproductive system, such primary ovarian insufficiency and polycystic ovary syndrome are associated with infertility and recurrent miscarriage, as well as increased risk of adverse health outcomes, including cardiovascular disease and type 2 diabetes. For many of these conditions, the contributing molecular and cellular processes are poorly understood. The overarching similarities between mice and humans have rendered mouse models irreplaceable in understanding normal physiology and elucidating pathological processes that underlie disorders of the female reproductive system. The utilization of Cre-LoxP recombination technology, which allows for spatial and temporal control of gene expression, has identified the role of numerous genes in development of the female reproductive system and in processes, such as ovulation and endometrial decidualization, that are required for the establishment and maintenance of pregnancy in mammals. In this comprehensive review, we provide a detailed overview of Cre drivers with activity in the neuroendocrine-reproductive axis that have been used to study disruptions in key intracellular signaling pathways. We first summarize normal development of the hypothalamus, pituitary, ovary, and uterus, highlighting similarities and differences between mice and humans. We then describe human conditions resulting from abnormal development and/or function of the organ. Finally, we describe loss-of-function models for each Cre driver that elegantly recapitulate some key features of the human condition and are associated with impaired fertility. The examples we provide illustrate use of each Cre driver as a tool for elucidating genetic and molecular underpinnings of reproductive dysfunction.
Mercury impairs human primary endometrial stromal cell function
Authors: Palomar Andrea , González-Martín Roberto , Pérez-Debén Silvia , Medina-Laver Yassmin , Quiñonero Alicia , Domínguez Francisco 
Published: January 2022

AbstractHeavy metal exposures could compromise endometrial cells. Although studies assessed mercury toxicity in cell lines, limited data are available on the concentration of mercury that damage human endometrial stromal cells (hEnSCs) and alter endometrial function. This research aims to study the effects of mercury exposure on cell viability and functional features of hEnSCs. Primary hEnSCs were isolated from 23 endometrial biopsies obtained from healthy donors. After in vitro mercury exposure cell viability of hEnSCs was evaluated via tetrazolium salt metabolism and oxidative stress was assessed by 2′, 7′-dichlorofluorescin diacetate assay. hEnSCs were decidualized in vitro in the presence of mercury (0, 25, 50, 75, 250, and 350 nM). Decidualization was evaluated based on prolactin and insulin-like growth factor-binding protein (IGFBP1) secretion and cytoskeletal rearrangement (F-actin staining). Cell proliferation and apoptosis were evaluated by Ki67 immunostaining and TUNEL assay. Mercury doses of 250 nM (P = 0.028) and 500 nM (P = 0.026) increased reactive oxygen species production in hEnSCs after 24 h. Cell viability significantly decreased after 48 h and 72 h (P &lt; 0.05) of mercury exposure at 500 nM. After in vitro decidualization and mercury treatment, decidual hEnSCs showed a dose-dependent decrease in prolactin and IGFBP1 secretion, particularly at 350 nM (P = 0.016). Cell proliferation was decreased in hEnSCs treated with 350 nM mercury (P &lt; 0.001); an increase in apoptosis followed a dose-dependent trend in non-decidual and decidual hEnSCs. These findings support that mercury-induced damage could be due to an increase in ROS production.
Excessive follicle-stimulating hormone during ovarian stimulation of cattle may induce premature luteinization of most ovulatory-size follicles
Authors: Clark Zaramasina L , Karl Kaitlin R , Ruebel Meghan L , Latham Keith E , Ireland James J 
Published: January 2022

Abstract
High follicle-stimulating hormone (FSH) doses during ovarian stimulation are detrimental to ovulatory follicle function and decrease live birth rate in cattle and women. However, the mechanism whereby excessive FSH causes ovarian dysfunction is unknown. This study tested the hypothesis that excessive FSH during ovarian stimulation induces premature luteinization of ovulatory-size follicles. Small ovarian reserve heifers were injected twice daily for 4 days with 70 IU (N = 7 heifers) or 210 IU (N = 6 heifers) Folltropin-V [commercial FSH-enriched preparation of porcine pituitary glands with minor (&lt;1%) luteinizing hormone (LH) contamination, cpFSH]. Ovulatory-size (≥10 mm) follicles were excised from ovaries after the last cpFSH injection and hormone concentrations in follicular fluid (FF) were determined using ELISA. Luteinization was monitored by assessing cumulus cell–oocyte complex (COC) morphology and measuring concentrations of estradiol (E), progesterone (P), and oxytocin (O) in FF. COCs were classified as having compact (cCOC) or expanded (eCOC) cumulus cell layers, and as estrogen-active (E:P in FF ≥1), estrogen-inactive (EI, E:P in FF ≤1 &gt; 0.1), or extreme-estrogen-inactive (EEI, E:P in FF ≤0.1). A high proportion (72%) of ovulatory-size follicles in 210 IU, but not 70 IU, dose heifers displayed eCOCs. The high doses also produced higher proportions of EI or EEI follicles which had lower E:P ratio and/or E but higher P and/or O concentrations compared with the 70 IU dose heifers. In conclusion, excessive cpFSH doses during ovarian stimulation may induce premature luteinization of most ovulatory-size follicles in heifers with small ovarian reserves.
Exploring human factors in the operating room: scoping review of training offerings for healthcare professionals
Authors: Lee Alex , Finstad Alexandra , Tipney Ben , Lamb Tyler , Rahman Alvi , Devenny Kirsten , Abou Khalil Jad , Kuziemsky Craig , Balaa Fady 
Published: January 2022

Abstract

Background
Human factors (HF) integration can improve patient safety in the operating room (OR), but the depth of current knowledge remains unknown. This study aimed to explore the content of HF training for the operative environment.

Methods
We searched six bibliographic databases for studies describing HF interventions for the OR. Skills taught were classified using the Chartered Institute of Ergonomics and Human Factors (CIEHF) framework, consisting of 67 knowledge areas belonging to five categories: psychology; people and systems; methods and tools; anatomy and physiology; and work environment.

Results
Of 1851 results, 28 studies were included, representing 27 unique interventions. HF training was mostly delivered to interdisciplinary groups (n = 19; 70 per cent) of surgeons (n = 16; 59 per cent), nurses (n = 15; 56 per cent), and postgraduate surgical trainees (n = 11; 41 per cent). Interactive methods (multimedia, simulation) were used for teaching in all studies. Of the CIEHF knowledge areas, all 27 interventions taught ‘behaviours and attitudes’ (psychology) and ‘team work’ (people and systems). Other skills included ‘communication’ (n = 25; 93 per cent), ‘situation awareness’ (n = 23; 85 per cent), and ‘leadership’ (n = 20; 74 per cent). Anatomy and physiology were taught by one intervention, while none taught knowledge areas under work environment.

Conclusion
Expanding HF education requires a broader inclusion of the entirety of sociotechnical factors such as contributions of the work environment, technology, and broader organizational culture on OR safety to a wider range of stakeholders.
Developmental maturation of causal signaling hubs in voluntary control of saccades and their functional controllability
Authors: Zhang Yuan , Ryali Srikanth , Cai Weidong , Supekar Kaustubh , Pasumarthy Ramkrishna , Padmanabhan Aarthi , Luna Bea , Menon Vinod 
Published: January 2022

Abstract
The ability to adaptively respond to behaviorally relevant cues in the environment, including voluntary control of automatic but inappropriate responses and deployment of a goal-relevant alternative response, undergoes significant maturation from childhood to adulthood. Importantly, the maturation of voluntary control processes influences the developmental trajectories of several key cognitive domains, including executive function and emotion regulation. Understanding the maturation of voluntary control is therefore of fundamental importance, but little is known about the underlying causal functional circuit mechanisms. Here, we use state-space and control-theoretic modeling to investigate the maturation of causal signaling mechanisms underlying voluntary control over saccades. We demonstrate that directed causal interactions in a canonical saccade network undergo significant maturation between childhood and adulthood. Crucially, we show that the frontal eye field (FEF) is an immature causal signaling hub in children during control over saccades. Using control-theoretic analysis, we then demonstrate that the saccade network is less controllable in children and that greater energy is required to drive FEF dynamics in children compared to adults. Our findings provide novel evidence that strengthening of causal signaling hubs and controllability of FEF are key mechanisms underlying age-related improvements in the ability to plan and execute voluntary control over saccades.
Episodic memory in aspects of brain information transfer by resting-state network topology
Authors: Yan Tianyi , Wang Gongshu , Wang Li , Liu Tiantian , Li Ting , Wang Luyao , Chen Duanduan , Funahashi Shintaro , Wu Jinglong , Wang Bin , Suo Dingjie 
Published: January 2022

Abstract
Cognitive functionality emerges due to neural interactions. The interregional signal interactions underlying episodic memory are a complex process. Thus, we need to quantify this process more accurately to understand how brain regions receive information from other regions. Studies suggest that resting-state functional connectivity (FC) conveys cognitive information; additionally, activity flow estimates the contribution of the source region to the activation pattern of the target region, thus decoding the cognitive information transfer. Therefore, we performed a combined analysis of task-evoked activation and resting-state FC voxel-wise by activity flow mapping to estimate the information transfer pattern of episodic memory. We found that the cinguloopercular (CON), frontoparietal (FPN) and default mode networks (DMNs) were the most recruited structures in information transfer. The patterns and functions of information transfer differed between encoding and retrieval. Furthermore, we found that information transfer was a better predictor of memory ability than previous methods. Additional analysis indicated that structural connectivity (SC) had a transportive role in information transfer. Finally, we present the information transfer mechanism of episodic memory from multiple neural perspectives. These findings suggest that information transfer is a better biological indicator that accurately describes signal communication in the brain and strongly influences the function of episodic memory.
The transition from invariant to action-dependent visual object representation in human dorsal pathway
Authors: He HuiXia , Zhuo Yan , He Sheng , Zhang Jiedong 
Published: January 2022

AbstractThe human brain can efficiently process action-related visual information, which supports our ability to quickly understand and learn others’ actions. The visual information of goal-directed action is extensively represented in the parietal and frontal cortex, but how actions and goal-objects are represented within this neural network is not fully understood. Specifically, which part of this dorsal network represents the identity of goal-objects? Is such goal-object information encoded at an abstract level or highly interactive with action representations? Here, we used functional magnetic resonance imaging with a large number of participants (n = 94) to investigate the neural representation of goal-objects and actions when participants viewed goal-directed action videos. Our results showed that the goal-directed action information could be decoded across much of the dorsal pathway, but in contrast, the invariant goal-object information independent of action was mainly localized in the early stage of dorsal pathway in parietal cortex rather than the down-stream areas of the parieto-frontal cortex. These results help us to understand the relationship between action and goal-object representations in the dorsal pathway, and the evolution of interactive representation of goal-objects and actions along the dorsal pathway during goal-directed action observation.
Continuous theta burst stimulation over left and right supramarginal gyri demonstrates their involvement in auditory feedback control of vocal production
Authors: Li Tingni , Zhu Xiaoxia , Wu Xiuqin , Gong Yulai , Jones Jeffery A , Liu Peng , Chang Yichen , Yan Nan , Chen Xi , Liu Hanjun 
Published: January 2022

Abstract
The supramarginal gyrus (SMG) has been implicated in auditory-motor integration for vocal production. However, whether the SMG is bilaterally or unilaterally involved in auditory feedback control of vocal production in a causal manner remains unclear. The present event-related potential (ERP) study investigated the causal roles of the left and right SMG to auditory-vocal integration using neuronavigated continuous theta burst stimulation (c-TBS). Twenty-four young adults produced sustained vowel phonations and heard their voice unexpectedly pitch-shifted by ±200 cents after receiving active or sham c-TBS over the left or right SMG. As compared to sham stimulation, c-TBS over the left or right SMG led to significantly smaller vocal compensations for pitch perturbations that were accompanied by smaller cortical P2 responses. Moreover, no significant differences were found in the vocal and ERP responses when comparing active c-TBS over the left vs. right SMG. These findings provide neurobehavioral evidence for a causal influence of both the left and right SMG on auditory feedback control of vocal production. Decreased vocal compensations paralleled by reduced P2 responses following c-TBS over the bilateral SMG support their roles for auditory-motor transformation in a bottom-up manner: receiving auditory feedback information and mediating vocal compensations for feedback errors.