bluuebunny/crossref_metadata_2025_split huggingface dataset:
Síndrome de Allan-Herndon-Dudley: un diagnóstico a descartar ante todo lactante varón con hipotonía sin causa determinada
Authors: Molina Herranz David , Moreno Sánchez Amelia , Fariña Jara María Violeta , Pérez Delgado Raquel , Labarta Aizpún Jose Ignacio , Sánchez Marco Silvia , Izquierdo Álvarez Silvia , López Pisón Javier 
Published: June 2022

El síndrome de Allan-Herndon-Dudley es un raro trastorno genético, ligado al cromosoma X, producido por déficit del transportador monocarboxilato 8 (MCT8), que es un transportador específico de hormonas tiroideas principalmente a nivel cerebral. Produce un cuadro neurológico grave de inicio precoz, en el que predomina la hipotonía muscular. Objetivo: Presentar un caso infrecuente con diagnóstico inesperado, destacando la utilidad de solicitar un perfil tiroideo completo ante todo lactante varón con hipotonía muscular sin causa determinada. Caso Clínico: Lactante masculino de 10 meses de edad, con gran hipotonía axial y periférica, debilidad con escasa movilidad espontánea, sin sostén cefálico ni sedestación estable. Se realizaron estudios metabólicos y neurofisiológicos periférico completos, y estudios genéticos de Atrofia Espinal, Prader Willi y Distrofia Miotónica. El exoma a tríos detectó una variante probablemente patogénica c.359C>T;p.(Ser120Phe), en hemicigosis en el exón 1 del gen SLC16A2, heredada de la madre. Se objetivaron alteraciones tiroideas con aumento de triyodotironina (T3 libre) y hormona estimulante de la tiroides (TSH), y retraso de la mielinización cerebral. Conclusiones: La sospecha de déficit de transportador MCT8 debe incluirse en el estudio del lactante masculino con hipotonía y debilidad sin causa determinada. El diagnóstico se orienta con un perfil tiroideo que incluya la hormona T3 libre, dado que presenta un perfil tiroideo característico con disminución de tiroxina libre (T4), aumento de T3 libre y niveles normales o ligeramente elevados de TSH. La implementación del exoma a tríos pudo establecer en este caso un diagnóstico de certeza de forma precoz.
Pesan Dalam Foto Brassai Berjudul Bijou Of The Montmatre Cabarets
Authors: Astiti Anin 
Published: June 2022

Brassai works titled "Bijou" of the Montmartre cabarets is very interesting theory revealed by semiotics. The photo is one of the works in the project Brassai Paris by Night is doing to document Paris at night. On the work found several signs that can be described with particular semiotic theory of semiotics Barthes. "Bijou" of the Montmartre cabarets is a representation of the nightlife in Paris which is illustrated by the figure of an old woman who works as an entertainer with a background in a nightclub atmosphere. The visual expression achieved with the proper use of photographic techniques by Barthes either through the use of natural light and a standard lens.Â Key words: photography, sign, semiotica
PENGEMBANGAN BUKU CERITA MATEMATIKA PADA KELAS VII SMP DALAM MATERI PERBANDINGAN
Authors: Desi D. , Lumbantoruan J. H. 
Published: June 2022

This study aims to determine the feasibility of developing an mathematics story book. The method used in this study is "Research and Development". Meanwhile, the data collection technique in this study was a validator questionnaire from the experts, then quantitative and qualitative data were analyzed descriptively.Based on the results of research and development that has been done, it shows that: mathematics story books get a very decent percentage value. This percentage is obtained from the results of the validation of each expert i.e. Material experts with a percentage of 80.92%, experts in presenting material with a percentage of 79.16%, media experts giving a score of 93.75%, and linguists giving a score of 81.25%. So it can be concluded that the average value of the percentage of experts is in the very feasible category with a percentage value of 83.77%. Based on the explanation above, it can be concluded that the electronic mathematics storybook is very suitable to be used as a learning tool in class VII SMP in comparison material.
Keywords: development, mathematics storybook, comparison.
JARAK GENETIK DAN KEKERABATAN TIGA JENIS BADAK DI DUNIA BERDASARKAN ANALISIS MtDNA
Authors: Handayani  , Dedi Duryadi  , Hadi Alikodra3  
Published: June 2022

The family Rhinocerotidae is distinct and well defined, but systematic relationships among the four genera evaluated on the basis of geographical distribution of the different genera. The purpose of the research is to find out the genetic distance of rhinos in the world. Samples of Sumatran rhinoceros (Indonesia) are from SRS (Sumatran Rhino Sanctuary) Way Kambas National Park, while for Indian rhinoceros and white African rhinos. Amplification of cytochrome oxidase 1 (CO1) genes in mitochondrial DNA ( mtDNA) uses a specific primer for COI. The two primary pairs are Primer to amplify the partial CO1 sequence (RHCO1F & RHCO1R). CO1 amplification process PCR conditions used are: predenaturation at 940C, followed by the main cycle denaturation stage at 940C for 45 seconds, primary annealing stage (annealing) at 580C. analyzed provides genetic distance ranging from (0.016) to (0.147) for each species. Analysis of 711 bp of rhino DNA sequences can be shown in the form of a matrix of genetic differences. The genetic distance of the white African rhinoceros (Ceratorium simum) with the Sumatran torgamba rhinoceros is (0.142), while with the Indian rhinoceros (0.147) and the genetic distance between the Sumatran rhinos themselves there is a difference that the Sumatran rhino Bina differs by (0.136-0.147) with the other three individuals, while Torgamba has a genetic distance with Rosa of (0.014) but with a very close genetic distance (0.007), and Andalas (0.017), while the genetic distance is close to Bina (0.014) with Rosa (0.014).
POTENSI EKSTRAK DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) DAN MINYAK ATSIRI SERAI (Cymbopogon citratus (DC.) Stapf) SEBAGAI BAHAN AKTIF HAND SANITIZER SPRAY
Authors: Felma Mosse Adonia , Prasetyaningsih Aniek , Adityarini Dwi 
Published: June 2022

Maintaining hand hygiene is an important habit to prevent disease caused by microorganisms and viruses. Handsanitizer is one of hygiene products as antibacterial and practical use. However, the use of alcohol as its main ingredient could irritate skin. Therefore, the alternative of alcohol is urgently found to prevent this side effect in same effectiveness. in this research, Binahong (Anredera cordifolia (Ten.) Steenis leaf extract and lemongrass oil (Cymbopogon citratus (DC.) Stapf) are used to replace alcohol as the main ingredient. This study aims to know the potential antibacterial activity of binahong leaf extract, lemongrass oil and its combination against S.aureus and its effectiveness as an active ingredient in hand sanitizer spray. Binahong extraction using the maceration method. The secondary metabolites of both extracts were identified by phytochemical assay. Then, their antibacterial activity was determined using a disk diffusion test for S. aureus. The organoleptic of hand sanitizer spray was observed. The highest antibacterial activity was obtained from the combination of binahong leaf extract and lemongrass oil 100% at ratio 1:1. This combination was used to formulate the hand sanitizer spray. The highest inhibitory activity of hand sanitizer spray was shown in the formulation with 3% active ingredients (extracts). This product had dark yellow in colour, distinctive aroma, and liquid texture and effectively suppresses bacterial growth on the hands. According to the results, binahong leaf extract and lemongrass oil are potentially used as active ingredients for natural hand sanitizer sprays.
UJI EFEKTIVITAS EPIKARPIUM BUAH NANGKA (artocarpus heterophyllus lamarck.) SEBAGAI SEDIAAN KRIM TABIR SURYA UV-B
Authors: Tara Inastu Kandarp  , Prasetyaningsih Aniek , Cantya Prakasita Vinsa 
Published: June 2022

Sunscreen is needed as protection against the skin from exposure to UV rays, because it will cause erythema, aging skin, blistering, and skin cancer, in skin that is not protected by sunscreen. This study aims to determine the in vitro and in vivo ability of epicarpium A. heterophyllus extract sunscreen cream preparations. This research was conducted in vitro and in vivo, beginning with the extraction process with the maceration method using 70% ethanol, identification of compounds in the extract, TLC, GC-MS, total flavonoids test, physical quality of cream preparations, SPF values ​​of extracts and creams, and in vivo sunscreen activity tests were conducted. The yield percentage produced from 450 grams of simplicia powder was 47.61%. The compounds in A. heterophyllus epicarpium extract are flavonoids, tannins, saponins, terpenoids, steroids, fatty acid groups, alcohol groups, and alkanes. Crude extract contains total flavonoids of 43.625 mgQE / g extract. The 75% concentration in the cream preparation had the highest SPF value of 8.173. The in vivo test used the MED (Minimal Erythema Dose) method of erythema scoring. A concentration of 75% gives the lowest MED value of 0.25. This research is expected to provide information on alternative uses of natural ingredients as the main ingredient of sunscreen so that the use of chemicals as the main ingredient will be reduced.
Implementasi Pendidikan Agama Islam Terhadap Karakter Siswa di SMA Al-Hidayah Way Seputih Lampung Tengah
Authors: Sakur Abdul , Jaenullah Jaenullah , Jannah Siti Roudhotul 
Published: June 2022

Pendidikan merupakan salah satu kebutuhan primer masyarakat sejak dulu, dan setiap orang memerlukan pendidikan untuk kelangsungan hidupnya. Tujuan pendidikan sering dirumuskan untuk menyiapkan generasi muda menjadi orang dewasa anggota masyarakat yang mandiri dan produktif. Namun demikian, mutu pendidikan belum menunjukkan peningkatan yang berarti. Sebagian sekolah, terutama di kota-kota menunjukkan peningkatan mutu pendidikan yang cukup menggembirakan, namun sebagian besar lainnya masih memprihatinkan. Salah satu alternatif yang dapat dilakukan dalam melaksanakan pendidikan karakter disekolah adalah mengoptimalkan pembelajaran materi pendidikan agama Islam (PAI). Peran pendidikan agama khususnya pendidikan agama Islam sangatlah strategis dalam mewujudkan pembentukan karakter siswa. Pendidikan agama merupakan sarana transformasi pengetahuan dalam aspek keagamaan (Aspek kognitif), sebagai sarana transformasi norma serta nilai moral untuk membentuk sikap (aspek afektif), yang berperan dalam mengendalikan prilaku (aspek psikomotorik) sehingga tercipta kepribadian manusia seutuhnya. Berdasarkan indikator dari penelitian ini adalah untuk meningkatkan karakter siswa untuk menjadi lebih baik lagi terutama pada mata pelajaran PAI. Berdasarkan hasil observasi dan wawancara dengan kepala sekolah serta guru PAI salah satu cara mengatasi kenakalan pada siswa yaitu dengan cara menerapkan metode pendidikan agama islam dalam setiap kesempatan. Metode pendidikan yang dimaksud yaitu melalui penekanan system cara belajar baik secara teori maupun praktek langsung baik melalui acara hari-hari besar islam atau dalam proses belajar mengajar siswa dikelas atau didalam kelas
Kata Kunci: Pendidikan Karakter, Implementasi Pendidikan Karakter, Mutu Pendidikan
Pengaruh Kecerdasan Emosional dan Interpersonal Terhadap Hasil Belajar PAI Siswa SMA Ma’arif Bumirestu Palas Lampung Selatan
Authors: Laviyanto Nur Apri , Syaifullah Muhammad , Jaenullah Jaenullah 
Published: June 2022

Penelitian ini didasarkan pada masalah adanya kesenjangan antara kecerdasan emosional, interpersonal dan hasil belajar PAI. Rumusan masalah dalam penelitian ini adalah "Apakah ada pengaruh kecerdasan ‎emosional terhadap hasil belajar PAI siswa‎SMA Ma`arif Buni Restu Palas Lampung ‎Selatan tahun pelajaran 2020/2021 ‏Apakah ada pengaruh kecerdasan interpersonal ‎terhadap hasil belajar PAI ‎siswa SMA Ma`arif Buni Restu Palas Lampung Selatan tahun ‎pelajaran ‎‎2020/2021?‎‏ dan‎ Apakah ada pengaruh kecerdasan emosional dan kecerdasan ‎interpersonal ‎terhadap hasil belajar PAI siswa SMA Ma`arif Buni Restu Palas ‎Lampung ‎Selatan tahun pelajaran 2020/2021? ‏Penelitian ini menggunakan metode penelitian ‎kuantitatif. Populasi penelitian ‎ini ‎sebanyak ‏‎80 orang, dan seluruh populasi tersebut ‎dijadikan sampel. ‎Pengumpulan data ‎menggunakan angket, ‎dan ‏dokumentasi. Analisis ‎data menggunakan rumus regresi linear berganda. Hasil penelitian menunjukkan bahwa ‏kecerdasan emosional dan interpersonal berpengaruh signifikan ‎tehadap hasil belajar PAI siswa SMA Ma`arif Bumi Restu Palas Kabupaten Lampung ‎Selatan. Hasil penelitian ini diperoleh persamaan‎ȳ=47,476‎+‎0,227X1+0,152X2Konstanta‎‎‎47,476‎‏ ‏‎‏ ‏menggambarkan besarnya hasil belajar ‎PAI jika tidak ‎dipengaruhi kecerdasan emosional dan kecerdasan interpersonal. ‎Koefisien ‎regresi b1 sebesar 0,227‎‏ ‏menggambarkan besarnya peningkatan ‎hasil belajar, jika disertai ‎variabel kecerdasan emosional, sedangkan ‎koefisien regresi b2 sebesar 0,152‎ menggambarkan besarnya pening-katan ‎hasil belajar jika disertai kecerdasan interpersonal.
Kata Kunci: Kecerdasan Emosional, Kecerdasan Interpresonal, Hasil Belajar
Intervention of Peer Groups in Strengthening Youth Religious Character Based on Art Activities Rebbana
Authors: Zaenullah Zaenullah , Anwar Rosyida Nurul 
Published: June 2022

Ideally, students should receive education not only at school, but also from family and community. Because children are part of society, they are more in the environment where they live. Thus, intervention to strengthen religious character also needs to be carried out by all parties, including the youth community such as religious arts club. The purpose of this study is how peers intervene in strengthening religious characters based on art activity using tambourine. This research method uses descriptive qualitative. Data collection techniques in this study were carried out through participatory observation (as both observer and participant), in-depth interviews (deep interviews), and documentation. The data analysis of this research uses the Miles and Huberman model. Data analysis takes place when data collection is carried out and after data collection for a certain period that cannot be determined. The data analysis includes data reduction (data reduction), data display (data presentation), and conclusion drawing/verification (drawing conclusions/verification). The results showed that the intervention to strengthen religious character was focused on art-based religious activities which were carried out programmatically could create a good environment for the fulfillment of inner experiences from religious practice. This also act as a strategy to minimize youth activities that do not give any benefits for themselves and their social environment. The approach used is a value-planting approach and an action approach.
Keywords: Religious Character, Strengthening Religious Character, Degradation Moral
Macroeconomic Analysis of Mining Stock Index Volatility in Indonesia
Authors: Anggraini Asterina , Ahmad Gatot Nazir , Prihatni Rida 
Published: June 2022

The purpose of this study is to analyze the influence of macroeconomic variables, such as, exchange rates, interest rates, inflation rates, and consumer price index on mining stock volatility. The unit of analysis is the mining stock index volatility in Indonesia from January 2010 to December 2019. The analytical method used in the study is the econometric model ARCH/GARCH using EViews software. The test results show the exchange rate of the dollar against the rupiah (USD/IDR) and the inflation rate has a negative and significant effect while the interest rate and the consumer price index have a positive and significant effect on mining stock index volatility in Indonesia. In addition, based on the ARCH/GARCH coefficient is found that the mining stock index in Indonesia is influenced by the volatility of the current and past stock indexes. The mining stock index volatility in Indonesia is persistent volatile, which is high volatility and occurs continuously.
Keywords: Macroeconomic Analysis, Minix Stock Index, Index Volatility
The Influence of Instructional Media E-Learning Based Edmodo on Student Learning Outcomes of Basics Banking Class X Accounting
Authors: Dewi Monica , Zulaihati Sri , Fauzi Achmad 
Published: June 2022

This study aims to determine the effect of Edmodo-based e-learning media on student learning outcomes in the subjects of banking basics class X Accounting at SMK Negeri 42 Jakarta. The research method used is a quasi-experimental method with a research design post-test only control design. The samples taken were class X Accounting 2 as the experimental class and X Accounting 1 as the control class with 36 students each. The instrument used is a test. The test results data were analyzed by normality test, homogeneity test and hypothesis testing. The results of the normality test showed that the experimental class obtained Lcount (0.113) < Ltable (0.147) this means the data is normally distributed and in the control class obtained Lcount (0.101) < Ltable (0.147) this means the data is normally distributed. The homogeneity test shows that Fcount (1.22) < Ftable (1.76) then the data used is homogeneous. The results of hypothesis testing state that tcount (13.79) < ttable (1.66) this means that there is an influence of Edmodo-based e-learning learning media on the learning outcomes of students of class X accounting expertise competence at SMK Negeri 42 Jakarta
Keywords: Learning Media, Learning Edmodo, Instructional Media E-Learning
Erfarenheter av krishantering i biståndshandläggningsmöten med äldre personer under covid-19 pandemin
Authors: Holmström Ebba , Andersson Katarina 
Published: June 2022

Bakgrund: Socionomer är en viktig profession i samhällets sociala skyddsnät och verksamma i många möten med sårbara grupper i kris. Den pågående globala coronapandemin är en stor kris som drabbat världen och speciellt äldre personer har drabbats hårt av pandemins konsekvenser.
Syfte: Studiens syfte var att undersöka och beskriva biståndshandläggares/socionomers erfarenheter av krishantering och möten med äldre personer under covid-19-pandemin.
Metod: En kvalitativ design med individuella semistrukturerade intervjuer genomfördes. Deltagarna rekryterades med ett ändamålsenligt urval och åtta biståndshandläggare intervjuades i en kommun i norra Sverige. Intervjuerna analyserades med kvalitativ innehållsanalys.
Resultat: Tre kategorier identifierades: erfarenhet av egen krishantering, nya perspektiv i arbetet, erfarenhet av kommunens krishantering och samhällsansvar.
Slutsats: Ett nytt arbetssätt har identifierats som innebär arbete på distans i hemmet. Äldre personers delaktighet i sin egen omsorg har minskat och försvårats under pandemin samt ensamhet, isolering, psykisk ohälsa och egenvald vanvård har ökat. Tjänsteutbudet har förändrats som en följd av distansarbete och pandemin och utbildningsbehov i krishantering har identifierats.
Efficacy and Safety of Oral Anticoagulants for Atrial Fibrillation Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis
Authors: Rhee Tae-Min , Lee So-Ryoung , Choi Eue-Keun , Oh Seil , Lip Gregory Y. H. 
Published: June 2022

BackgroundData on different direct oral anticoagulants (DOACs) in atrial fibrillation (AF) patients with renal impairment are insufficient. We aimed to perform pairwise and network meta-analysis comparing oral anticoagulants (OACs) in AF patients with renal impairment, including advanced chronic kidney disease (CKD) with creatinine clearance &lt;30 mL/min.MethodsPubMed, Embase, Cochrane Database, and references of related articles were searched up to April 2021. We included randomized trials and non-randomized studies using propensity-score or multivariable-model adjustments that compared clinical outcomes among OACs. Hazard ratios (HRs) for stroke or thromboembolism, major bleeding, and all-cause death were pooled using random-effects model.ResultsFrom 19 studies, 124,628 patients were included. In patients with AF and CKD, DOACs presented significantly lower risks of stroke or thromboembolism [HRpooled = 0.78, 95% confidence interval (CI) = 0.73–0.85, I2 = 16.6%] and major bleeding [HRpooled = 0.76 (0.64–0.89), I2 = 85.7%] when compared with warfarin, regardless of the severity of renal impairment. Results were consistent in advanced CKD patients for stroke or thromboembolism [HRpooled = 0.60 (0.43–0.85), I2 = 0.0%] and major bleeding [HRpooled = 0.74 (0.59–0.93), I2 = 30.4%]. In the network meta-analysis, edoxaban and apixaban presented the highest rank probability to reduce the risk of stroke or thromboembolism (edoxaban, P-score = 94.5%) and major bleeding (apixaban, P-score = 95.8%), respectively. Apixaban remained the safest OAC with the highest rank probability for major bleeding (P-score = 96.9%) in patients with advanced CKD.ConclusionDOACs, particularly apixaban and edoxaban, presented superior efficacy and safety than warfarin in AF patients with CKD. Apixaban was associated with the lowest risk of major bleeding among OACs for patients with advanced CKD.Systematic Review Registration[PROSPERO], identifier [CRD42021241718].
Intensity Dependent Effects of Interval Resistance Training on Myokines and Cardiovascular Risk Factors in Males With Obesity
Authors: Ataeinosrat Ali , Saeidi Ayoub , Abednatanzi Hossein , Rahmani Hiwa , Daloii Asieh Abbassi , Pashaei Zhaleh , Hojati Vida , Basati Gholam , Mossayebi Ali , Laher Ismail , Alesi Michaela G. , Hackney Anthony C. , VanDusseldorp Trisha A. , Zouhal Hassane 
Published: June 2022

ObjectiveTo determine the effects of different intensities of interval resistance training (IRT) protocols on the levels of select myokines (decorin, follistatin, myostatin, activin A, transforming growth factor beta-1 [TGF-β1]), and cardiometabolic and anthropometric measures in males with obesity.MethodsForty-four obese males (age: 27.5 ± 9.4 yr.; height: 165.4 ± 2.8 cm; weight: 97.9 ± 2.6 kg and BMI: 35.7 ± 4.3 kg/m2) were randomly assigned to one of four groups (n=11 per group): low-intensity interval resistance training (LIIRT), moderate-intensity interval resistance training (MIIRT), high-intensity interval resistance training (HIIRT) or control (C). The LIIRT group performed 10 exercises in 3 sets of 40% (20 repetitions), the MIIRT group performed 10 exercises in three sets of 60% (13 repetitions), and the HIIRT group performed 10 exercises in three sets of 80% (10 repetitions) of one maximum repetition (1RM), which were followed with active rest of 20% of 1RM and 15 repetitions. The resistance training groups exercised ~70 min per session, 3 days per week, for 12 weeks. Measurements were taken at baseline and after 12 weeks of exercise training.ResultsBaseline levels of myokines, cardiovascular risk factors, anthropometry, body composition, and cardio-respiratory fitness were not different between the four groups (p&gt;0.05). The group x time interactions for decorin, activin A, follistatin, myostatin, and TGF-β1, total cholesterol (TC), triglyceride (TG), high-density cholesterol (HDL), low-density cholesterol (LDL), anthropometry, body composition, and cardio-respiratory fitness were statistically significant (p&lt;0.05). There were increases in post-test values for decorin, follistatin, HDL (p&lt;0.05) and decreases in TC, TG, TGF-β1, LDL, and myostatin levels in the LIIRT, MIIRT, and HIIRT groups compared to pretest values (p&lt;0.05). Changes in fat mass, VO2peak,HDL, TG, glucose, activin A, decorin were not significant in LIIRT compared to the control group, while changes in activin A, follistatin, and TFG-β1 levels were greater in HIIRT and MIIRT groups compared to the LIIRT group (p&lt;0.05).ConclusionThe LIIRT, MIIRT, and HIIRT protocols all produced beneficial changes in decorin, activin A, follistatin, myostatin, and TGF-β1 levels, and cardiometabolic risk factors, with greater effects from the MIIRT and HIIRT protocols compared to LIIRT.