bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report: Indocyanine green fluorescence-guided imaging in laparoscope, a more sensitive detection technique of lateral lymph nodes metastases from rectal neuroendocrine tumors
Authors: Zhang Yueyang , Zhang Yi , Yang Yi , Xu Zheng , Gao Changyuan , Liu Meixi , Zhu Wenjia , Zhao Hong , Zhou Haitao 
Published: December 2022

BackgroundThe diagnosis and surgical strategy of lateral lymph node metastases of rectal neuroendocrine tumors are still controversial. At present, the major diagnostic means rely on imaging examinations, but will be affected by the size of lymph nodes leading to false negativity. We provide a new technique to determine lateral lymph node metastases during surgery.Clinical caseA 68-year-old man developed abdominal pain, bloating and fever for a month. Colonoscopy revealed the mass is 2.4 cm x 2.0 cm in size, with a wide stratum, poor mobility, and a rough but intact surface mucosa. Therefore, rectal neuroendocrine tumors (R-NET) were diagnosed. Multiple imaging methods, such as CT, octreotide imaging and endoscopic ultrasonography, have not found lateral lymph node metastases from rectal neuroendocrine tumors. But indocyanine green (ICG)-enhanced near-infrared fluorescence-guided imaging during surgery found left lateral lymph nodes metastases, which was proved by postoperative pathological examination.ConclusionsWe believe that applying ICG-enhanced near-infrared fluorescence-guided imaging in laparoscope can improve the detection of positive LLNs in those R-NET patients who did not reveal LNM on imaging examinations.
Patients’ related sexual outcomes in colorectal surgery
Authors: Liot Emilie , Christou Niki , de Sousa Sandra , Klein Jacques , Pouya Iranmanesh , Guedj Danae , Buchs Nicolas C. , Ris Frédéric 
Published: December 2022

BackgroundPatients undergoing colorectal surgery (CRS) have an increased risk of developing sexual disorders, attributed to different mechanisms. In this context, sexual function (SF) assessment of patients before and after surgery is essential: to identify risk factors for sexual disorders as well as to minimize their impact on overall quality of life (QoL), allowing them a satisfying relationship and sexual life.Material and methodsPatients over 18 years of age who underwent a CRS in the University Hospital of Geneva, Switzerland, between June 2014 and February 2016 were included. Our main objective was to compare and analyze the evolution of SF, QoL, and marital satisfaction (MS) before and after CRS. Specific and standardized tests were used.ResultsA cohort of 72 patients with a median age of 58.73 was analyzed. The majority of CRS was elective (91.5%). A percentage of 52.8% of patients underwent surgery for oncological reasons. There was no statistical difference in SF, sexual QoL, and MS before and after elective or emergency CRS for men. Interestingly, a significant decrease in women’s SF (FSFI) as well as their satisfaction within their couple (Locke–Wallace) until 12 months after surgery was found (p = 0.021). However, they showed a steady SF (GRISS) within their couple until 12 months after surgery.ConclusionRegarding knowledge about difficulties to talk about this intimate topic and gender differences, this general overview raises the question of the necessity to introduce in a long-course follow-up different methods of sexual health assessment with specific stakeholders.
Pediatric kidney transplants with multiple renal arteries show no increased risk of complications compared to single renal artery grafts
Authors: Riella Juliano , Tabbara Marina M. , Alvarez Angel , DeFreitas Marissa J. , Chandar Jayanthi , Gaynor Jeffrey J. , González Javier , Ciancio Gaetano 
Published: December 2022

BackgroundKidney allografts with multiple renal arteries (MRA) are not infrequent and have been historically associated with a higher risk of developing vascular and urologic complications. Reports of kidney transplantation using MRA allografts in the pediatric population remain scarce. The aim of this study was to evaluate if transplantation of allografts with MRA with a surgical intent of creating a single arterial inflow using vascular reconstruction techniques when required, and without the routine use of surgical drains or ureteral stents, is associated with an increased risk of complications when compared to single renal artery (SRA) grafts.MethodsWe retrospectively analyzed all pediatric renal transplant recipients performed by a single surgeon at our center between January 2015 and June 2022. Donor and recipient demographics, intraoperative data, and recipient outcomes were included. Recipients were divided into two groups based on SRA vs. MRA. Baseline variables were described using frequency distributions for categorical variables and means and standard errors for continuous variables. Comparisons of those distributions between the two groups were performed using standard chi-squared and t-tests. Time-to-event distributions were compared using the log-rank test.ResultsForty-nine pediatric transplant recipients were analyzed. Of these, 9 had donors with MRA (Group 1) and 40 had donors with SRA (Group 2). Native kidney and liver mobilization was performed in 44.4% (4/9) of Group 1 vs. 60.0% (24/40) of Group 2 cases (p = 0.39). There were no cases of delayed graft function or graft primary nonfunction. No surgical drainage or ureteral stents were used in any of the cases. One patient in Group 2 developed a distal ureter stricture. The geometric mean serum creatinine at 6- and 12-months posttransplant was 0.7 */ 1.2 and 0.9 */ 1.2 mg/dl in Group 1 and 0.7 */ 1.1 and 0.7 */ 1.1 mg/dl in Group 2. Two death-censored graft failures were observed in Group 2, with no significant difference observed between the two groups (p = 0.48).ConclusionsOur study demonstrates that pediatric renal transplantation with MRA grafts, using a surgical approach to achieve a single renal artery ostium, can be safely performed while achieving similar outcomes as SRA grafts and with a low complication rate.
C188-9, a specific inhibitor of STAT3 signaling, prevents thermal burn-induced skeletal muscle wasting in mice
Authors: Ono Yuko , Saito Masafumi , Sakamoto Kazuho , Maejima Yuko , Misaka Shingen , Shimomura Kenju , Nakanishi Nobuto , Inoue Shigeaki , Kotani Joji 
Published: December 2022

Burn injury is the leading cause of death and disability worldwide and places a tremendous economic burden on society. Systemic inflammatory responses induced by thermal burn injury can cause muscle wasting, a severe involuntary loss of skeletal muscle that adversely affects the survival and functional outcomes of these patients. Currently, no pharmacological interventions are available for the treatment of thermal burn-induced skeletal muscle wasting. Elevated levels of inflammatory cytokines, such as interleukin-6 (IL-6), are important hallmarks of severe burn injury. The levels of signal transducer and activator of transcription 3 (STAT3)—a downstream component of IL-6 inflammatory signaling—are elevated with muscle wasting in various pro-catabolic conditions, and STAT3 has been implicated in the regulation of skeletal muscle atrophy. Here, we tested the effects of the STAT3-specific signaling inhibitor C188-9 on thermal burn injury-induced skeletal muscle wasting in vivo and on C2C12 myotube atrophy in vitro after the administration of plasma from burn model mice. In mice, thermal burn injury severity dependently increased IL-6 in the plasma and tibialis anterior muscles and activated the STAT3 (increased ratio of phospho-STAT3/STAT3) and ubiquitin-proteasome proteolytic pathways (increased Atrogin-1/MAFbx and MuRF1). These effects resulted in skeletal muscle atrophy and reduced grip strength. In murine C2C12 myotubes, plasma from burn mice activated the same inflammatory and proteolytic pathways, leading to myotube atrophy. In mice with burn injury, the intraperitoneal injection of C188-9 (50 mg/kg) reduced activation of the STAT3 and ubiquitin-proteasome proteolytic pathways, reversed skeletal muscle atrophy, and increased grip strength. Similarly, pretreatment of murine C2C12 myotubes with C188-9 (10 µM) reduced activation of the same inflammatory and proteolytic pathways, and ameliorated myotube atrophy induced by plasma taken from burn model mice. Collectively, these results indicate that pharmacological inhibition of STAT3 signaling may be a novel therapeutic strategy for thermal burn-induced skeletal muscle wasting.
Obeticholic acid and ferrostatin-1 differentially ameliorate non-alcoholic steatohepatitis in AMLN diet-fed ob/ob mice
Authors: Li Shengjie , Zhuge Aoxiang , Wang Kaicen , Xia Jiafeng , Wang Qiangqiang , Han Shengyi , Shen Jian , Li Lanjuan 
Published: December 2022

Introduction: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are common chronic liver diseases with limited treatment options.Methods: Ob/ob mice (6 weeks old) were fed with the Control diet or amylin liver NASH (AMLN) diet for 24 weeks to establish the NASH, the AMLN diet-fed mice were treated with obeticholic acid (OCA), ferrostatin-1 (Fer-1) or their combination for 7 weeks. Finally, various clinical profiles were assessed.Results: Our results indicate that Fer-1 exerts better effects on improving body weight, blood glucose levels, transaminase levels and insulin resistance than OCA. OCA has a profound effect on ameliorating lipid accumulation. OCA and Fer-1 differentially inhibit the activation of hepatic Kupffer cells and HSCs. The combination of OCA and Fer-1 significantly reduces inflammation and protects mice against liver oxidative stress. OCA and Fer-1 differentially reshape the intestinal microbiota and affect the hepatic lipidome.Discussion: Our study compares the effects of OCA, Fer-1 and their combination on various clinical profiles in NASH. These data demonstrate that different drug combinations results in different improvements, and these discoveries provide a reference for the use of the OCA, Fer-1 and their combination in the clinical treatment of NAFLD/NASH.
Key defatting tissue pretreatment protocol for enhanced MALDI MS Imaging of peptide biomarkers visualization in the castor beans and their attribution applications
Authors: Qin Luyuan , Han Junshan , Wang Chuang , Xu Bin , Tan Deyun , He Song , Guo Lei , Bo Xiaochen , Xie Jianwei 
Published: December 2022

IntroductionCastor bean or ricin-induced intoxication or terror events have threatened public security and social safety. Potential resources or materials include beans, raw extraction products, crude toxins, and purified ricin. The traceability of the origins of castor beans is thus essential for forensic and anti-terror investigations. As a new imaging technique with label-free, rapid, and high throughput features, matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) has been gradually stressed in plant research. However, sample preparation approaches for plant tissues still face severe challenges, especially for some lipid-rich, water-rich, or fragile tissues. Proper tissue washing procedures would be pivotal, but little information is known until now.MethodsFor castor beans containing plenty of lipids that were fragile when handled, we developed a comprehensive tissue pretreatment protocol. Eight washing procedures aimed at removing lipids were discussed in detail. We then constructed a robust MALDI-MSI method to enhance the detection sensitivity of RCBs in castor beans.Results and DiscussionA modified six-step washing procedure was chosen as the most critical parameter regarding the MSI visualization of peptides. The method was further applied to visualize and quantify the defense peptides, Ricinus communis biomarkers (RCBs) in castor bean tissue sections from nine different geographic sources from China, Pakistan, and Ethiopia. Multivariate statistical models, including deep learning network, revealed a valuable classification clue concerning nationality and altitude.
A mixed-methods national study investigating key challenges in learning English as a foreign language: A Chinese college student perspective
Authors: Huang Jinyan , Li Junfei , Shu Tiantian , Zhang Yongfang 
Published: December 2022

IntroductionThis mixed-methods national study has a two-fold purpose: (a) to invite Chinese college students to rate their overall difficulties in the eight areas of English learning, i.e., listening, speaking, reading, writing, pronunciation, grammar, vocabulary, and culture; and (b) to invite them to identify their key challenges in learning EFL. Specifically, the following three research questions were asked: (a) what are their overall difficulties in the eight areas of learning EFL? (b) Are there significant differences in rating their overall difficulties in these eight areas across the demographic variables of gender (i.e., male versus female participants) and subject discipline (arts versus sciences versus English subject disciplines participants)? And (c) what are their key challenges in learning EFL?MethodsThe participants included a sample of 1,525 freshmen and sophomore students currently studying at seven universities across China. The instrument was a survey that consisted of a five-point Likert scale self-evaluation form and a major essay question addressing their key challenges. The qualitative data can help to probe deeply into the research setting to obtain in-depth understandings about Chinese college students’ English learning; and therefore, they can greatly enhance the quantitative data.Results and discussionThe quantitative results indicated that listening, speaking, and writing were their three key difficult areas in EFL learning; further, students’ subject discipline (arts versus sciences verse English subject disciplines) had significant effects on their perceived learning challenges in English listening and vocabulary. The qualitative results confirmed that listening, speaking, and writing were their three key challenging areas. Their specific learning challenges in each area were examined. Implications for Chinese college English teachers and administrators are discussed in terms of pedagogy and policy making, respectively.
Positive parenting style and positive health beyond the authoritative: Self, universalism values, and protection against emotional vulnerability from Spanish adolescents and adult children
Authors: Palacios Iria , Garcia Oscar F. , Alcaide Marta , Garcia Fernando 
Published: December 2022

IntroductionRecent research is fully questioning whether the combination of parenting warmth and strictness (the authoritative style) is always identified as positive parenting across the globe. This study analyzes parenting styles and the positive health of adolescents and adult children.MethodsThe sample was 2,090 Spanish children (59.9% women), from four age groups: 600 adolescents, 591 young adults, 507 middle-aged adults, and 392 older adults. Parenting styles (indulgent, authoritative, authoritarian, and neglectful) were obtained by warmth and strictness measures. Children’s positive health was measured by self (family self-concept, self-esteem, and negative self-efficacy), universalism values, and emotional vulnerability.ResultsThe main results showed that the indulgent parenting style was associated with equal and even better scores than the authoritative style, whereas the authoritarian and neglectful styles were consistently associated with low scores in positive health indicators for all age groups. However, two triple interactions of sex by age group by parenting style showed that women children from neglectful families reported the lowest family self-concept in old age and the highest emotional vulnerability in middle age.DiscussionThe study findings question the universal benefits of the so-called positive parenting (the authoritative style) for positive health.
The positive impact of informal spousal caregiving on the physical activity of older adults
Authors: Zan Hua , Shin Su Hyun 
Published: December 2022

IntroductionAlthough physical activity (PA) is crucial for health, the literature is mixed about how individuals' PA decisions are affected by their spouses. To fill this gap, we examined the extent to which providing care for one spouse affects the PA of the other spouse among those aged 50 or older in the United States.MethodsWe analyzed 9,173 older adults living with their spouses or partners from the 2004 to 2016 waves of the Health and Retirement Study. To identify the causal effect of spousal caregiving on the PA of older adults, we estimated individual-fixed effects models using a two-stage least squared instrumental variable approach with spousal falls as our instrument. We also estimated the models by splitting the sample by gender and race/ethnicity to identify heterogeneous impacts of spousal caregiving on PA decisions among subgroups.ResultsWe found that a one percentage point increase in the probability of providing care to spouses led to an increase in the probability of initiating moderate or vigorous PA (MVPA) by 0.34–0.52 percentage points. This effect was salient, especially among female and non-Hispanic white older adults.DiscussionCaregiving experience might provide opportunities to learn about caregiving burdens and trigger an emotional response about the salience of an event (i.e., they need care in the future). Older caregivers might start MVPA in an effort to improve or maintain their health and avoid burdening their families for caregiving in the future. This study demonstrated spousal influence on PA. Instead of delivering PA-promotion information (e.g., the harm of sedentary lifestyle and benefits of regular PA) to individuals, risk communication and education efforts on PA promotion might be more effective considering the family context. Family events such as health shocks or the emergence of caregiving needs from family members provide windows of opportunities for intervening. Subgroup differences should also be considered in targeted interventions.
Dissemination of Evidence by Cochrane Public Health Europe in German-Speaking Countries: An Online Stakeholder Survey
Authors: Griebler Ursula , Kien Christina , De Santis Karina K. , Stratil Jan , Borchard Annegret , Heise Thomas L. 
Published: December 2022

Objectives: To investigate the reach and impact of “Infomails”, email summaries of Cochrane reviews in German, regularly disseminated by Cochrane Public Health Europe (CPHE) to stakeholders in Austria, Germany and Switzerland.Methods: We analysed email campaign reports from 15 Infomails delivered until November 2020. Furthermore, we invited all previous Infomail recipients to participate in an online survey on the impact and perceptions regarding our Infomails in November 2020. We analysed the results using descriptive statistics.Results: The Infomails’ open rate ranged from 10.9% to 39.3% (median 26.0%), and the median click rate on the embedded links was 28.0% (range 8.6–53.8%), highest for nutrition and prevention topics. Out of 1259 recipients, 267 (21.2%) completed our survey. Infomails were most used in discussions, writing reports or statements, for policy or strategy development or programme or guideline development. Persons who remembered receiving Infomails rated them as useful, comprehensible or informative.Conclusion: Infomails summarising recent Cochrane reviews were considered useful for the daily work of public health stakeholders in German-speaking countries. Regular targeted messaging may increase the perceived usefulness.
Violences, jeunesse et médiatisation du désordre. De la « caillera » incorrecte au moralement correct
Authors: Boucher Manuel 
Published: December 2022

La violence s'oppose au calme, à la paix, elle perturbe l'ordre établi et effraye depuis toujours par son côté irrationnel. Aujourd'hui, derrière cette dimension polysémique et protéiforme, ce sont les «violences urbaines» qui inquiètent nos sociétés «hypermodernes». Ces violences seraient la démonstration que la radicalisation du processus de modernisation engendre la désorganisation sociale et l'anomie. Nous assistons à une dépolitisation, à une criminalisation et à une moralisation du désordre empêchant de penser la violence autrement qu'en la dénonçant. Or, des «croisés de la morale» associent les violences urbaines à la jeunesse des quartiers populaires décrite comme désocialisée, barbare et féroce.
Dans ce contexte, les pratiques à «risque» des jeunes des quartiers sont interprétées en noir ou en blanc. Une injonction axiologique contraint les jeunes à choisir entre le côté sombre de la violence et le côté «lumineux» de l'ordre moral. Pourtant, pour sortir de la coproduction de la violence, n'est-il pas temps de passer d'une dénonciation morale et de pratiques répressives à une conflictualisation et à une compréhension sociologique et politique d'actes demandant des réponses plurielles et adaptées ?
Revisiter les diasporas
Authors: Bordes-Benayoun Chantal 
Published: December 2022

L'accélération rapide et parfois tumultueuse des circulations humaines et leur complexité dans notre monde ont inscrit au programme des sciences sociales la nécessité de reconsidérer les objets et paradigmes classiques de l'étude des migrations. C'est dans ce contexte que le terme de diaspora semble rencontrer depuis peu une certaine fortune. Des passages et des contours, des tours et des détours, des exodes collectifs et des trajets et rêves plus personnels d'un ailleurs meilleur, des sordides et parfois mortelles traversées, des diffusions planétaires mais aussi des rétractions et replis locaux, bref de toutes les allées et venues plus ou moins hasardeuses qui bousculent nos topographies familières, une phénoménologie des diasporas pourrait rendre compte et embrasser la totalité. La réalité du franchissement des frontières, sous toutes ses formes, pousse en quelque sorte au franchissement des frontières des catégories et procédures de pensée par lesquelles nous avons coutume de passer.
Une sociologie des diasporas est-elle possible et à quelles conditions ? Au-delà de la dispersion spatiale, au-delà de la dissémination culturelle, et en prenant appui sur l'exemple historique des juifs, la problématique proposée considère l'homme diasporique dans son rapport au monde, dans l'invention permanente de sa relation aux autres. La diaspora n'est alors pas exclusivement exil, rupture, errance, mais aussi sédentarité, rétablissement, créativité.
Les territoires de la diaspora judéo-marocaine post-coloniale
Authors: Bordes-Benayoun Chantal 
Published: December 2022

Los territories de la diaspora judeomarroquí postcolonial
Entre las numerosas migraciones contemporàneas, la migración de los judios de Marruecos esta marcada a lo largo de la segunda mitad del siglo XIX por su carácter original, haciendo de esta un tipo modelo de diaspora. Dentro de la diaspora judia cuyo destino se réclama y comporte aparece muy singular en muchos aspectos : en primer lugar por su éxodo reciente cuyos fundamentos fueron multiples (económicos, politicos, identitarios, culturales) y a veces contradictorios, asi que por la extension de su dispersion geográfica ; en segundo lugar por la fuerza de las relaciones que sus miembros dispersas parecen mantener desde sus lugares de implantacióm respectivos ; en fin por el lazo peculiar que sobrevive con el pais de origen. Los primeros resultados de una encuesta internacional aqui presentados permiten apreciar la singularidad de este experimento migratorio, comprender la diversidad de las expresiones culturales e identitarias, y elaborar una tipologia de las formas de mobilidad.
La Teshuvah biblique. Conversion ou conversation ?
Authors: Des Rochettes Jacqueline 
Published: December 2022

The Biblical Teshuvah : Conversion or Conversation ?
This paper discusses the question and meaning of conversion in the biblical tradition. The analysis of the experience, both exemplary and complex, lived by Ruth the Moabite in the book of Ruth after her mother-in-law Naomi shows us her long march to a land, to a people and to a god that she does not know. Some aspects of her choice, which are common for all who decide to be converted, appear in her conversations. In the Bible as in life itself, conversion is lived under several forms, but the reason of one's choice remains basically a mystery.