bluuebunny/crossref_metadata_2025_split huggingface dataset:
(Na0.74Ag1.26)BaSnS4: A New AgGaS2‐Type Nonlinear Optical Sulfide with a Wide Band Gap and High Laser Induced Damage Threshold
Authors: Zhou Wenfeng , Liu Wenlong , Guo Sheng‐Ping 
Published: August 2022

AbstractThe development of high‐power solid‐state lasers is in urgent need of infrared (IR) nonlinear optical (NLO) materials with wide band gaps and high laser‐induced damage thresholds (LIDTs). Herein, a new compressed chalcopyrite‐like IR NLO crystal (Na0.74Ag1.26)BaSnS4 was successfully synthesized using a facile high‐temperature solid‐state method. Its structure can be considered as a variant of chalcopyrite AgGaS2 (AGS)‐type ones. It features a three‐dimensional framework constructed by corner‐sharing {[(Na/Ag)S4]7−}∞ layers and isolated SnS4 tetrahedra with negative cavities occupied by counter ion Ba2+. (Na0.74Ag1.26)BaSnS4 exhibits phase‐matchable moderate SHG response (0.31 × AGS), wide band gap (3.70 eV), and high LIDT (6.44 × AGS). Theoretical calculations reveal that the NLO response of (Na0.74Ag1.26)BaSnS4 is mainly originated from the synergetic effects of AgS4 and SnS4 tetrahedra, and the inclusion of alkaline and alkaline earth metals is responsible for the wide band gap and high LIDT. Moreover, the discovery of this chalcopyrite‐like compound will provide a feasible design strategy for the exploration of new promising IR NLO materials.
Discriminating Chiral Supramolecular Motions by Circularly Polarized Luminescence
Authors: Li Junfeng , Peng Xuelei , Hou Chenxi , Shi Shunan , Ma Jiamian , Qi Qi , Lai Wen‐Yong 
Published: August 2022

AbstractMolecular motions are closely associated with the behaviors and properties of organic materials. However, monitoring molecular motions is challenging. Herein, a chiral supramolecular system consisting of L‐/D‐phenylalanine (LPF/DPF) as a chiral inducer and an achiral tetraphenylethene derivative (TPEF) as a molecular rotor has been proposed and explored for real‐time discriminating the supramolecular motions by the visualization of circularly polarized luminescence (CPL) signal variations. Derived from the ordered molecular motions of TPEF induced by LPF/DPF, highly organized aggregates have been progressively assembled in a controlled manner with differentiated morphologies, including spherical particles, one‐dimensional fibers, and floor‐shaped supercrystals. Notably, increasing level of ordered aggregates, in turn, led to quenching emissions, while the CPL signals have been dramatically amplified accompanying by a sharp enhancement of luminescence dissymmetry factors (glum) from nearly 0 to −0.1. The significant amplification of CPL is attributed to the ordered aggregates of supramolecules, leading to the decrease of electric transition dipole moments in supramolecular system. As a result of the chiral supramolecular motions powered by supramolecular crystallization, the supramolecular motions are conveniently discriminated by visual CPL signal variation with an enhancement of glum value from 0 to −0.1 in real time.
Phase partition and KPI‐related process monitoring for batch processes using a novel canonical correlation analysis strategy
Authors: Gao Xuejin , He Zihe , Gao Huihui , Qi Yongsheng 
Published: August 2022

AbstractKey performance indicators (KPI)‐related process monitoring has been of great significance to ensure product quality and economic benefits for batch processes. Considering that different phases exhibit different characteristics, one of the key issues is how to partition the whole batch process into different phases and characterize them separately by multiple phase models. In order to model and monitor batch processes more accurately and efficiently, a novel canonical correlation analysis (CCA) strategy is proposed in this paper. The phase partition algorithm is designed based on the joint canonical variable matrix (JCVM). Different from previous methods, it considers the time sequence of operation phases and can distinguish the phase switches from dynamics anomalies. Using this algorithm, phases are separated in order from a KPI‐related perspective, revealing high correlation among variables. After phase partition, a novel multi‐phase local neighbourhood standardization CAA (MPLNSCCA) method focusing on KPI is set up for online monitoring, which could further address the misclassification problems. The advantages of the proposed method are illustrated by two case studies, a penicillin simulation platform and an industrial application of Escherichia coli fermentation, respectively.
Weighted lens depth: Some applications to supervised classification
Authors: Cholaquidis Alejandro , Fraiman Ricardo , Gamboa Fabrice , Moreno Leonardo 
Published: August 2022

AbstractStarting with Tukey's pioneering work in the 1970s, the notion of depth in statistics has been widely extended, especially in the last decade. Such extensions include those to high‐dimensional data, functional data, and manifold‐valued data. In particular, in the learning paradigm, the depth‐depth method has become a useful technique. In this article, we extend the lens depth to the case of data in metric spaces and study its main properties. We also introduce, for Riemannian manifolds, the weighted lens depth. The weighted lens depth is nothing more than a lens depth for a weighted version of the Riemannian distance. To build it, we replace the geodesic distance on the manifold with the Fermat distance, which has the important property of taking into account the density of the data together with the geodesic distance. Next, we illustrate our results with some simulations and also in some interesting real datasets, including pattern recognition in phylogenetic trees, using the depth‐depth approach.
Atrial fibrillation bleeding risk and prediction while treated with direct oral anticoagulants in warfarin‐naïve or warfarin‐experienced patients
Authors: Perino Alexander C. , Fan Jun , Pundi Krishna , Schmitt Susan , Kothari Mitra , Din Natasha , Heidenreich Paul A. , Turakhia Mintu P. 
Published: August 2022

AbstractBackgroundIn patients with atrial fibrillation (AF) treated with direct oral anticoagulants (DOAC), bleeding risk scores provide only modest discrimination for major or intracranial bleeding. However, warfarin experience may impact HAS‐BLED (Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly (>65 years), Drugs/alcohol concomitantly) score performance in patients evaluated for DOACs, as HAS‐BLED was derived and validated in warfarin cohorts.MethodsWe performed a retrospective cohort study of patients prescribed DOAC for AF in the Veterans Health Administration between 2010 and 2017. We determined modified HAS‐BLED score discrimination and calibration for bleeding, for patients treated with DOAC, stratified by prior warfarin exposure. We also determined the association between DOAC–warfarin‐naïve status to bleeding (nonintracranial and intracranial) with DOAC–warfarin‐experienced patients as reference.ResultsThe DOAC analysis cohort included 100, 492 patients with AF (age [mean ± SD]: 72.9 ± 9.6 years; 1.7% female; 90.1% White), of which 26, 760 patients (26.6%) and 73, 732 patients (73.4%) were warfarin experienced or naïve, respectively. HAS‐BLED discrimination for bleeds was modest for patients treated with DOAC, regardless of prior warfarin experience (concordance statistics: 0.53–0.59). For DOAC–warfarin‐naïve patients, as compared to DOAC–warfarin‐experienced patients, adjusted risk of intracranial bleeding was lower, while risk of nonintracranial bleeding was higher (intracranial bleeding propensity adjusted with inverse probability of treatment weights [IPTWs]: hazard ratio [HR]: 0.86, 95% confidence interval [CI]: 0.78–0.95, p = .0040) (nonintracranial bleeding propensity adjusted with IPTW: HR: 1.15, 95% CI: 1.11–1.19, p < .0001).ConclusionPatients’ modified HAS‐BLED score at the time of DOAC initiation, regardless of prior warfarin use, provided only modest discrimination for intracranial and nonintracranial bleeds. These data argue against maintaining DOAC eligible patients on warfarin therapy regardless of modified HAS‐BLED score.
Structural Phase Transitions in Anthracene Crystals
Authors: Hino Yuto , Matsuo Takumi , Hayashi Shotaro 
Published: August 2022

AbstractInvited for this month′s cover is the collaborating group of Prof. Shotaro Hayashi at Kochi University of Technology. The cover picture shows anthracene molecules depicted among sakura blossoms at Kochi University of Technology (KUT). Anthracenes are arranged with falling petals, giving a beautiful image of the molecular crystal engineering field. The cover was designed by Yuto Hino. More information can be found in the Review by S. Hayashi and co‐workers.
Glycolaldehyde as a Bio‐Based C1 Building Block for Selective N‐Formylation of Secondary Amines
Authors: Flynn Matthew T. , Liu Xin , Dell'Acqua Andrea , Rabeah Jabor , Brückner Angelika , Baráth Eszter , Tin Sergey , de Vries Johannes G. 
Published: August 2022

AbstractBiomass derived glycolaldehyde was employed as C1 building block for the N‐formylation of secondary amines using air as oxidant. The reaction is atom economic, highly selective and proceeds under catalyst free conditions. This strategy can be used for the synthesis of cyclic and acyclic formylamines, including DMF. Mechanistic studies suggest a radical oxidation pathway.
Enriched environment rescues neonatal pain induced cognitive deficits and the impaired hippocampal synaptic plasticity later in life
Authors: Min Cuiting , Ling Ru , Chen Mengying , Xia Dongqing , Chen Ran , Li Xiaonan 
Published: August 2022

AbstractAlthough extensive and untreated pain that occurs during a critical developmental window may impair cognition later in life, environmental interventions early in life might promote cognition. However, the underlying mechanism is poorly understood. Our current study utilized a rat model of “repetitive needle pricks” from the day of birth (P0) to postnatal day 7 (P7) to mimic the painful experience of preterm neonates in the neonatal intensive care unit. Enriched environment (EE) during development period (from P15 to P70) was implemented as a nonpharmacological intervention approach. Electrophysiological recording, behavioral tests, and biochemical analysis were performed after the end of EE (between P71 and P80). The results showed neonatal repetitive pain resulted in a reduction in mechanical withdrawal thresholds by the von Frey test in P70 (p < .001). Furthermore, neonatal repetitive pain impaired spatial learning and memory (p < .05) and even led to dysfunction in fear memory (p < .01). In contrast, EE rescued neonatal pain‐induced cognitive deficits and normalized hippocampal long‐term potentiation in rats exposed to neonatal pain (p << .05). The beneficial effect of EE might be the improvements in hippocampal synaptic plasticity via upregulating neurotrophic factors and N‐methyl‐d‐aspartate (NMDA) receptors in the hippocampus. Our findings provide evidence that early environmental intervention might be a safe strategy to overcome neurodevelopmental abnormalities in preterm infants who experienced multiple procedural painful events during the early critical period.
Dual Palladium‐Photoredox Catalyzed C−H functionalization
Authors: Saha Partha Sarathi , Gopinath Purushothaman 
Published: August 2022

AbstractFunctionalization of unactivated C−H bonds is a highly desirable process in organic chemistry as it gives direct access to new functional groups in a single step. This process is generally achieved using transition metal catalysts, and among them, palladium plays an important role due to its unique reactivity. Recently, photoredox catalysis has witnessed a huge surge, and many new and valuable organic reactions are uncovered periodically. Dual transition metal – photoredox catalysis on the other hand, has taken organic synthesis to new heights by achieving transformations that were previously not possible or difficult to achieve by both forms of catalysis independently. In this direction, many new and interesting dual palladium‐photoredox catalyzed C−H functionalization reactions combining the synergistic effects of both palladium and photoredox have been reported in the past few years, and it is imperative to summarize these reactions for further developments in this area.
Designing a Peptide‐modified Screen‐printed Gold Electrode as a Sensor for the Human Monocytic Leukemia Cell Line
Authors: Kodaira Keito , Kuramitz Hideki , Sugawara Kazuharu 
Published: August 2022

AbstractWe designed a screen‐printed gold electrode (SPGE) with a peptide to detect cancer cells. The ability to sense circulating tumor cells (CTCs) and monitor their movement in blood vessels is important for cancer diagnosis. Human monocytic leukemia cells were selected as a model of CTCs because of their origin. The cell‐recognition and cell‐sensing peptide moieties were EICADP and Y4C. The SPGE was modified with the cell‐recognition moieties of the CY4EICADPY4C in a bridge‐type construction due to the cysteine residue at both terminals. The calibration curve was linear and ranged from 25 to 2,000 cells/mL with a LOD of 8 cells/mL.
Ferrocene derivatives with planar chirality and their enantioseparation by liquid‐phase techniques
Authors: Peluso Paola , Mamane Victor 
Published: August 2022

AbstractIn the last decade, planar chiral ferrocenes have attracted a growing interest in several fields, particularly in asymmetric catalysis, medicinal chemistry, chiroptical spectroscopy and electrochemistry. In this frame, the access to pure or enriched enantiomers of planar chiral ferrocenes has become essential, relying on the availability of efficient asymmetric synthesis procedures and enantioseparation methods. Despite this, in enantioseparation science, these metallocenes were not comprehensively explored, and very few systematic analytical studies were reported in this field so far. On the other hand, enantioselective high‐performance liquid chromatography has been frequently used by organic and organometallic chemists in order to measure the enantiomeric purity of planar chiral ferrocenes prepared by asymmetric synthesis. On these bases, this review aims to provide the reader with a comprehensive overview on the enantioseparation of planar chiral ferrocenes by discussing liquid‐phase enantioseparation methods developed over time, integrating this main topic with the most relevant aspects of ferrocene chemistry. Thus, the main structural features of ferrocenes and the methods to model this class of metallocenes will be briefly summarized. In addition, planar chiral ferrocenes of applicative interest as well as the limits of asymmetric synthesis for the preparation of some classes of planar chiral ferrocenes will also be discussed with the aim to orient analytical scientists towards ‘hot topics’ and issues which are still open for accessing enantiomers of ferrocenes featured by planar chirality.
Superior cycle performance of Li metal electrode with {110} surface texturing
Authors: Hu Xitao , Gao Yao , Zhang Biao , Shi Le , Li Quan 
Published: August 2022

AbstractLi metal foil is a most promising candidate for Li metal batteries, but its poor cycle stability remains a major obstacle limiting its development for practical applications. In the present work, we show that crystallographic orientation (surface texturing) of Li foil plays a key role in determining the cycle performance of the Li metal anode in both symmetrical cells and full cells. Li foil of {110} texturing is demonstrated to have superior cycling stability when compared to Li {100} or pristine Li foils without specific texturing. Experimental evidence and computational modeling suggest that the enhanced cycle performance of Li {110} originates from the low‐surface energy/surface diffusion barrier associated with the Li {110} plane, leading to not only dense Li plating but also uniform stripping during cycling. Capacity retention of 96.1% (125.0 mAh/g) after 400 cycles is demonstrated in a full cell with Li {110} anode and LiFePO4 cathode at 1 C. This work adds to the current understanding of electrochemical plating/stripping of Li metal, and leads to new technologies that can largely extend the cycle life of Li metal electrode for the next generation of energy storage devices.image
The effect of gender on end‐user preferences for yam quality descriptors
Authors: Effah‐Manu Liticia , Wireko‐Manu Faustina D. , Agbenorhevi Jacob K. , Maziya‐Dixon Bussie , Oduro Ibok N. , Baah‐Ennum Theresa Y. 
Published: August 2022

AbstractImproving the effectiveness of breeding programs could be achieved by breeding for consumers' preferences. The relationship between gender and consumer preferences for yam was studied using purposeful sampling for key informants, focus group discussions (FGDs), and individual interviews. Data from qualitative interviews were transcribed and quantitative data analyzed using SPSS (version 20). Cramer's V (Phi) and logistic regressions were used to explain the observations. Males prioritized income‐generating varieties over females, while females ranked tuber morphological characteristics high. Sex‐based preference for yams showed that moldability and sweet taste are preferred by both females and males. Moderately hard boiled yams and shelf stable food products are liked by males, whereas aroma is rated highly by females. Males described yams that have a longer digestion time as “heavy” and preferred such varieties. Watery tubers and tubers not turning brown are important characteristics during processing. The Phi of 0.157 and 0.163 for sex and ethnic groups show moderate to strong associations between choices for descriptors by females, males, and various ethnic groups. These findings imply that gender disaggregation of information on preference for yam quality descriptors should be considered in future yam breeding programs as it may improve adoption rate and enhance food security.
Bioactivity‐guided isolation of anti‐inflammatory limonins from Chukrasia tabularis
Authors: Shen Jin‐Huang , Zhang Yi‐Fan , Zhang Li , Yang Na‐Na , Ma Xin‐Hua , Zhong Tian‐Hua , Zhang Yong‐Hong 
Published: August 2022

AbstractChukrasia tabularis is an economically important tree and widely cultured in the southeast of China. Its barks, leaves, and fruits are consumed as a traditional medicine and perceived as a valuable source for bioactive limonin compounds. The extracts from root barks of C. tabularis showed significant anti‐inflammatory effect. The aim of this research was to explore the material basis of C. tabularis anti‐inflammatory activity, and to purify and identify anti‐inflammatory active ingredients. By a bioassay‐guided isolation of dichloromethane fraction obtained two novel phragmalin limonins, Chukrasitin D and E (1 and 2), together with 12 known limonins (3–14). The chemical structure of these compounds is determined on the basis of extensive spectral analysis and chemical reactivity. In addition, the activities of these isolated limonins on the production of nitric oxide (NO), tumor necrosis factor alpha (TNF‐α), and nuclear factor kappa B (NF‐κB) in RAW264.7 cells induced by lipopolysaccharide (LPS) were evaluated. Limonins 1 and 2 indicated significant anti‐inflammatory activity with IC50 values of 6.24 and 6.13 μM. Compound 1 notably inhibited the production of NF‐κB, TNF‐α and interleukin 6 (IL‐6) in macrophages. The present results suggest that the root barks of C. tabularis exhibited anti‐inflammatory effect and the limonins may be responsible for this activity.
The contribution of edible cricket flour to quality parameters and sensory characteristics of wheat bread
Authors: Bartkiene Elena , Starkute Vytaute , Katuskevicius Konstantinas , Laukyte Neringa , Fomkinas Markas , Vysniauskas Edikas , Kasciukaityte Paulina , Radvilavicius Emilis , Rokaite Skaiste , Medonas Domantas , Valantinaviciute Emilija , Mockus Ernestas , Zokaityte Egle 
Published: August 2022

AbstractThis study evaluated the influence of edible cricket flour (ECF) on the quality parameters and sensory characteristics of wheat bread (WB), including the formation of volatile compounds (VC) and their relationship with emotions (EM) induced for consumers. ECF reduced dough pH, redness, and yellowness. At 5%, ECF increased the porosity of WB (by 7.87%). The quantity of ECF significantly affected WB's specific volume (p = .030), porosity (p = .0001), shape coefficient (p = .0001), and mass loss (p = .023). All WB with ECF had a more intense color and additive odor. Bread samples with 10% and 15% ECF had more intense overall, additive, acidity, and bitterness flavors. However, all WB had similar overall acceptability (OA) and no correlations were found between OA and VC. The EM “happy” and “sad” were expressed more intensely for WB with 15% ECF, and significant correlations were established between the EM “happy” and separate VC. The main VC in WB were ethanol; 1‐butanol and 3‐methyl; 1‐hexanol; estragole; and hexanoic acid. Finally, 5% ECF could be incorporated into the main WB formula without having a negative impact on bread quality. Also, ECF influences VC formation, and separate VC could be related to emotions induced for consumers.
Astrocyte‐specific loss of lactoferrin influences neuronal structure and function by interfering with cholesterol synthesis
Authors: Xu Shuang‐Feng , Pang Zhong‐Qiu , Fan Yong‐Gang , Zhang Yan‐Hui , Meng Yu‐Han , Bai Chen‐Yang , Jia Meng‐Yu , Chen Yan‐Hong , Wang Zhan‐You , Guo Chuang 
Published: August 2022

AbstractGrowing evidence indicates that circulating lactoferrin (Lf) is implicated in peripheral cholesterol metabolism disorders. It has emerged that the distribution of Lf changes in astrocytes of aging brains and those exhibiting neurodegeneration; however, its physiological and/or pathological role remains unknown. Here, we demonstrate that astrocyte‐specific knockout of Lf (designated cKO) led to decreased body weight and cognitive abnormalities during early life in mice. Accordingly, there was a reduction in neuronal outgrowth and synaptic structure in cKO mice. Importantly, Lf deficiency in the primary astrocytes led to decreased sterol regulatory element binding protein 2 (Srebp2) activation and cholesterol production, and cholesterol content in cKO mice and/or in astrocytes was restored by exogenous Lf or a Srebp2 agonist. Moreover, neuronal dendritic complexity and total dendritic length were decreased after culture with the culture medium of the primary astrocytes derived from cKO mice and that this decrease was reversed after cholesterol supplementation. Alternatively, these alterations were associated with an activation of AMP‐activated protein kinase (AMPK) and inhibition of SREBP2 nuclear translocation. These data suggest that astrocytic Lf might directly or indirectly control in situ cholesterol synthesis, which may be implicated in neurodevelopment and several neurological diseases.