bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks
Authors: Li Yue , Miao Yong , Yang Lunan , Zhao Yitao , Wu Keke , Lu Zhihui , Hu Zhiqi , Guo Jinshan 
Published: July 2022

AbstractDue to the abuse of antibiotics and the emergence of multidrug resistant microorganisms, medical devices, and related biomaterials are at high risk of microbial infection during use, placing a heavy burden on patients and healthcare systems. Metal–phenolic networks (MPNs), an emerging organic–inorganic hybrid network system developed gradually in recent years, have exhibited excellent multifunctional properties such as anti‐inflammatory, antioxidant, and antibacterial properties by making use of the coordination between phenolic ligands and metal ions. Further, MPNs have received widespread attention in antimicrobial infections due to their facile synthesis process, excellent biocompatibility, and excellent antimicrobial properties brought about by polyphenols and metal ions. In this review, different categories of biomaterials based on MPNs (nanoparticles, coatings, capsules, hydrogels) and their fabrication strategies are summarized, and recent research advances in their antimicrobial applications in biomedical fields (e.g., skin repair, bone regeneration, medical devices, etc.) are highlighted.
Advanced Cathode Materials for Protonic Ceramic Fuel Cells: Recent Progress and Future Perspectives
Authors: Wang Ning , Tang Chunmei , Du Lei , Zhu Ruijie , Xing Lixin , Song Zhongqian , Yuan Baoyin , Zhao Lei , Aoki Yoshitaka , Ye Siyu 
Published: July 2022

AbstractIntermediate‐temperature proton ceramic fuel cells (PCFCs)–a promising power generation technology–have attracted significant attention in recent years because of their unique advantages over conventional high‐temperature solid oxide fuel cells and low‐temperature proton exchange membrane fuel cells. The cathodes of PCFCs simultaneously require efficient channels for proton, oxide‐ion, and electron transfer; therefore, designing and engineering cathode materials with tailorable H+, O2−, and e− conductivities are crucial for improving PCFC performance. Despite significant efforts and critical progress in this field, exploring the desired cathode materials remains challenging. This review provides a comprehensive and critical overview of oxide materials for PCFC cathodes, particularly triple H+/O2−/e− conductors. Their proton uptake, conduction mechanisms, and structure–property relationships are focused on to guide future material design. In addition, the electrochemical performance of these cathode materials in PCFCs is discussed and the electrochemical performance gaps among PCFCs with different types of cathode materials are defined. Finally, perspectives on the development of high‐performance PCFCs are proposed.
Pharmacological Chaperones for GCase that Switch Conformation with pH Enhance Enzyme Levels in Gaucher Animal Models
Authors: Santana Andrés G. , Robinson Kyle , Vickers Chelsea , Deen Matthew C. , Chen Hong‐Ming , Zhou Stephen , Dai Ben , Fuller Maria , Boraston Alisdair B. , Vocadlo David J. , Clarke Lorne A. , Withers Stephen G. 
Published: July 2022

AbstractGaucher disease is a lysosomal storage disorder caused by mutations which destabilize the native folded form of GCase, triggering degradation and ultimately resulting in low enzyme activity. Pharmacological chaperones (PCs) which stabilize mutant GCase have been used to increase lysosomal activity through improving trafficking efficiency. By engineering their inherent basicity, we have synthesized PCs that change conformation between the ER and the lysosomal environment, thus weakening binding to GCase after its successful trafficking to the lysosome. NMR studies confirmed the conformational change while X‐ray data reveal bound conformations and binding modes. These results were further corroborated by cell studies showing increases in GCase activity when using the pH‐switchable probe at low dosing. Preliminary in vivo assays with humanized mouse models of Gaucher showed enhanced GCase activity levels in relevant tissues, including the brain, further supporting their potential.
Recent Advances in Host‐Guest Supramolecular Hydrogels for Biomedical Applications
Authors: Wang Suxi , Ong Pin Jin , Liu Songlin , Thitsartarn Warintorn , Tan Maureen Janet Beng Hoon , Suwardi Ady , Zhu Qiang , Loh Xian Jun 
Published: July 2022

AbstractThe recognition‐directed host‐guest interaction is recognized as a valuable tool for creating supramolecular polymers. Functional hydrogels constructed through the dynamic and reversible host‐guest complexation are endowed with a great many appealing features, such as superior self‐healing, injectability, flexibility, stimuli‐responsiveness and biocompatibility, which are crucial for biological and medicinal applications. With numerous topological structures and host‐guest combinations established previously, recent breakthroughs in this area mostly focus on further improvement and fine‐tuning of various properties for practical utilizations. The current contribution provides a comprehensive overview of the latest developments in host‐guest supramolecular hydrogels, with a particular emphasis on the innovative molecular‐level design strategies and hydrogel formation methodologies targeting at a wide range of active biomedical domains, including drug delivery, 3D printing, wound healing, tissue engineering, artificial actuators, biosensors, etc. Furthermore, a brief conclusion and discussion on the steps forward to bring these smart hydrogels to clinical practice is also presented.
Multiepitope‐based vaccine design by exploring antigenic potential among leptospiral lipoproteins using comprehensive immunoinformatics and structure‐based approaches
Authors: Kumar Pankaj , Shiraz Mohd. , Akif Mohd. 
Published: July 2022

AbstractLeptospirosis is a tropical and globally neglected zoonotic disease caused by pathogenic spirochetes, Leptospira. Although the disease has been studied for decades, a potent or effective vaccine is not available so far. Efforts are being made to design an efficient vaccine candidate using different approaches. Immunoinformatics approaches have been proven to be promising in terms of time and cost. Here, we used immunoinformatics and structure‐based approaches to evaluate antigenic B‐ and T‐cell epitopes present on the leptospiral lipoproteins (LipL). The promiscuous overlapping epitopes (B‐cell, T‐cell, interferon (IFN)‐γ positive, and non‐allergens), which can induce humoral, cell‐mediated, and innate immunity, were selected to generate a multiepitope chimeric vaccine. To enhance the vaccine immunogenicity, a Toll‐like receptor (TLR) agonist was fused to the vaccine with a suitable linker. The chimeric vaccine structure was predicted for molecular docking studies with immune receptors. Moreover, the stability of the vaccine–immune receptor complexes was analyzed by normal mode analysis (NMA). The potency of the vaccine construct was predicted by the immune simulation tool. The study provides additional information toward constructing peptide‐based chimeric vaccines against Leptospira.
What topics should or should not be included in software security education—Qualitative content analysis
Authors: Ebad Shouki A. 
Published: July 2022

AbstractSoftware security education is still not preparing students for the types of high‐skilled technical roles that represent the most severe workforce shortage. Recognizing this, academia has begun redefining the knowledge area concepts of software security curricula to meet the current workforce shortage. This article studies the software security courses in Arab Gulf academic programs and benchmarks their descriptions with the corresponding knowledge area from cybersecurity Curricula (CSEC). 2017, the first set of global cybersecurity curricular guidelines. Using content analysis, six concepts or essentials are investigated: security requirements, secure design principles, secure source code, analysis and testing, patch, and ethics. It was found that no course follows all the CSEC. 2017 essentials. The analysis and testing essential were considered by all courses, and security after deployment, including the patch essential, needs more attention because it was not included in any course. Similarly, the security requirements and ethics essentials were also considered by a few courses. However, software success depends on requirements, and ethics has become critical in the cybersecurity and information assurance fields that depend on law and forensics. The secure source code essential was covered by most courses. The well‐known types of code attacks were covered, and over half of the courses discussed secure design principles essential. However, security by design is an emerging development philosophy. The article discussed observations and recommendations that will assist program managers and their staff in making effective decisions about the essentials and concepts that should be included when they are developing the software security curriculum.
DDX24 promotes metastasis by regulating RPL5 in non‐small cell lung cancer
Authors: Hu Xinyan , Li Fangfang , Zhou Yulan , Gan Hairun , Wang Tiancheng , Li Luting , Long Haoyu , Li Bing , Pang Pengfei 
Published: July 2022

AbstractPurposeNon‐small cell lung cancer (NSCLC) is a leading cause of cancer death, and metastasis is a crucial determinant of increased cancer mortality. DDX24 has garnered increased attention due to its correlation with tumorigenesis and malignant progression. However, the correlation between DDX24 and NSCLC remains unclear.MethodsDDX24 expression in NSCLC tissues and survival rate of patients was analyzed using bioinformatic analysis. Transwell assays, wound‐healing assays, and tail vein lung colonization models were employed to determine the role of DDX24 in migration and invasion in vitro and in vivo. We searched for DDX24‐interacting proteins using co‐immunoprecipitation followed by mass spectroscopy and verified the interaction. The influence of DDX24 on RPL5 expression and ubiquitination was examined using protein stability assays.ResultsDDX24 expression was upregulated in NSCLC cell lines and tumors of patients, particularly those with high tumor grades. A high DDX24 level was also correlated with a poor prognosis. DDX24 upregulation enhanced the migration and invasion ability of NSCLC cells, whereas its downregulation had the opposite effects. In vivo xenograft experiments confirmed that tumors with high DDX24 expression had higher metastatic abilities. The interaction between DDX24 and RPL5 promoted its ubiquitination and destabilized it.ConclusionsDDX24 acted as a pro‐tumorigenic factor and promoted metastasis in NSCLC. DDX24 interacted with RPL5 to promote its ubiquitination and degradation. As a result, targeting DDX24/RPL5 axis may provide a novel potential therapeutic strategy for NSCLC.
Therapists' experiences of a brief case formulation and alliance focused pre‐treatment training session (CALL)
Authors: Jacobsen Celia Faye , Mathiesen Birgit Bork , Poulsen Stig , Lunn Susanne , Dahlgaard Mads , Nielsen Jan 
Published: July 2022

AbstractObjectiveA general lack of supervision outcome studies and new advancements within therapist training methods inspired us to develop a randomised controlled trial, Case formulation and ALLiance (CALL), testing the efficacy of a brief pre‐treatment training session. CALL combines generic case formulation and alliance principles with the supervision of a specific client. This qualitative study acts as a preliminary to the randomised controlled trial and aims to explore psychologists' experiences of participating in CALL.MethodSemi‐structured interviews were conducted with seven psychologists in private practice, who participated in CALL between January and May 2020. The transcribed interviews were analysed using thematic analysis.ResultsThe psychologists described CALL as a clinically useful and collegial experience but simultaneously conveyed a lack of recollection of the training session and doubts as to its enduring utilisation.ConclusionCALL has the potential to positively influence the process and outcome of therapy through the fostering of case formulation and alliance management skills, as well as a strong supervisory alliance. However, the familiar content or brief format of the session, and participants' memory bias, may have limited the utilisation and recall of the intervention.
An accidental emamectin benzoate poisoning in child: A case report
Authors: Yadav Gopal Kumar , Rohita Dipesh Kumar , Mandal Krishna Chandra , Paudel Binod , Devkot Ashok Raj 
Published: July 2022

AbstractWe report a case of accidental Emamectin Benzoate poisoning in a six‐year‐old child resulting in nausea, vomiting, abdominal pain, and confusion. We did vigorous gastric lavage with saline, activated charcoal, and coconut oil. The other supportive treatment improved the outcome of the patient with complete resolution of symptoms.
Intraoperative recurrent laryngeal nerve monitoring in unconventional thyroid surgery
Authors: Filippo Carta , Valeria Marrosu , Valeria Pinto , Melania Tatti , Bontempi Mauro , Cinzia Mariani , Roberto Puxeddu 
Published: July 2022

AbstractThe most common surgical risk after total thyroidectomy remains the recurrent laryngeal nerve (RLN) injury. Nowadays, the use of intraoperative nerve monitoring systems (IONM) such as the endotracheal tube‐based is recommended to prevent RLN palsy. The use of the nerve monitoring is standardized by dedicated guidelines on the basis of a normal laryngeal anatomy, but previous head and neck surgical procedures may complicate its application. The authors herewith present a case of a non‐conventional use of endotracheal tube‐based IONM in a 72‐year‐old patient who underwent to a second‐stage total thyroidectomy for metastatic papillary cancer incidentally detected after an open partial horizontal laryngectomy (OPHL) extended to one arytenoid (Type IIa + ary left) for squamous cell carcinoma. The use of the endotracheal tube‐based IONM in such particular case where the function of the only remaining arytenoid had to be absolutely preserved was effective in avoiding the RLN accidental injury. The authors reviewed the non‐traditional use of IONM and described the procedure in case of thyroidectomy in patients previously treated by OPHL.
The importance of inspection in clinical cardiology: Frank's sign
Authors: Bazoukis George , Papadatos Stamatis S. , Varrias Dimitrios , Tse Gary 
Published: July 2022

AbstractThe Frank's sign (FS) is a diagonal earlobe crease running from the tragus to the edge of the auricle. In this case, we describe a 71 years‐old male patient with FS who presented to the emergency department complaining of epigastric pain. A non‐ST elevation myocardial infarction was diagnosed.
Discovery of Complex Binding and Reaction Mechanisms from Ternary Gases in Rare Earth Metal–Organic Frameworks
Authors: Christian Matthew S. , Nenoff Tina M. , Rimsza Jessica M. 
Published: July 2022

AbstractUnderstanding the selectivity of metal–organic frameworks (MOFs) to complex acid gas streams will enable their use in industrial applications. Herein, ab initio molecular dynamic simulations (AIMD) were used to simulate ternary gas mixtures (H2O‐NO2‐SO2) in rare earth 2,5‐dihydroxyterephthalic acid (RE‐DOBDC) MOFs. Stronger H2O gas‐metal binding arose from thermal vibrations in the MOF sterically hindering access of SO2 and NO2 molecules to the metal sites. Gas‐gas and gas‐linker interactions within the MOF framework resulted in the formation of multiple secondary gas species including HONO, HNO2, NOSO, and HNO3−. Four gas adsorption sites were identified along with a new de‐protonation reaction mechanism not observable through experiment. This study not only provides valuable information on competitive gas binding energies in the MOF, it also provides important chemical insights into transient chemical reactions and mechanisms.
Drivers of racial, regional, and socioeconomic disparities in late‐stage breast cancer mortality
Authors: Moubadder Leah , Collin Lindsay J. , Nash Rebecca , Switchenko Jeffrey M. , Miller‐Kleinhenz Jasmine M. , Gogineni Keerthi , Ward Kevin C. , McCullough Lauren E. 
Published: July 2022

BackgroundThe authors identified tumor, treatment, and patient characteristics that may contribute to differences in breast cancer (BC) mortality by race, rurality, and area‐level socioeconomic status (SES) among women diagnosed with stage IIIB–IV BC in Georgia.MethodsUsing the Georgia Cancer Registry, 3084 patients with stage IIIB–IV primary BC (2013–2017) were identified. Cox proportional hazards regression was used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) comparing mortality among non‐Hispanic Black (NHB) versus non‐Hispanic White (NHW), residents of rural versus urban neighborhoods, and residents of low‐ versus high‐SES neighborhoods by tumor, treatment, and patient characteristics. The mediating effects of specific characteristics on the association between race and BC mortality were estimated.ResultsAmong the study population, 41% were NHB, 21% resided in rural counties, and 72% resided in low SES neighborhoods. The authors observed mortality disparities by race (HR, 1.27; 95% CI, 1.13, 1.41) and rurality (HR, 1.14; 95% CI, 1.00, 1.30), but not by SES (HR, 1.04; 95% CI, 0.91, 1.19). In the stratified analyses, racial disparities were the most pronounced among women with HER2 overexpressing tumors (HR, 2.30; 95% CI, 1.53, 3.45). Residing in a rural county was associated with increased mortality among uninsured women (HR, 2.25; 95% CI, 1.31, 3.86), and the most pronounced SES disparities were among younger women (<40 years: HR, 1.46; 95% CI, 0.88, 2.42).ConclusionsThere is considerable variation in racial, regional, and socioeconomic disparities in late‐stage BC mortality by tumor, treatment, and patient characteristics.
Alpha‐Nickel Hydroxide Coating of Metallic Nickel for Enhanced Alkaline Hydrogen Evolution
Authors: Xue Song , Liang Yunchang , Hou Shujin , Zhang Yajing , Jiang Heqing 
Published: July 2022

AbstractIn this work, alkaline hydrogen evolution reaction (HER) processes of three typical nickel‐based electrocatalysts [i. e., Ni, α‐Ni(OH)2, and β‐Ni(OH)2] were investigated to probe critical factors that determine the activity and durability. The HER activity trend was observed as Ni≫α‐Ni(OH)2>β‐Ni(OH)2, likely attributed to a synergy between metallic Ni and Ni(OH)2 components on the Ni surface and fast water dissociation kinetics on the α‐Ni(OH)2 surface. With the HER proceeding, the metallic Ni surface, however, gradually became α‐Ni(OH)2, and α‐Ni(OH)2 surface ultimately transformed into β‐phase, leading to a dramatic activity decrease of Ni electrodes. Therefore, Ni electrodes were coated with α‐Ni(OH)2 nanosheets to slow down the nickel hydroxylation and optimize the surface ratio of Ni(OH)2 to metallic Ni. This simple coating procedure enhanced both activity and durability of Ni electrocatalysts.
Involvement of MST1/mTORC1/STAT1 activity in the regulation of B‐cell receptor signalling by chemokine receptor 2
Authors: Zhu Yingzi , Gu Heng , Yang Lu , Li Na , Chen Qiuyue , Kang Danqing , Lin Shengyan , Jing Yukai , Jiang Panpan , Chen Qianglin , Luo Li , Liu Ju , Chang Jiang , Li Zhenzhen , Wang Yi , Dai Xin , Miller Heather , Westerberg Lisa S. , Park Chan‐Sik , Kubo Masato , Gong Quan , Dong Lingli , Liu Chaohong 
Published: July 2022

AbstractBackgroundCCR2 is involved in maintaining immune homeostasis and regulating immune function. This study aims to elucidate the mechanism by which CCR2 regulates B‐cell signalling.MethodsIn Ccr2‐knockout mice, the development and differentiation of B cells, BCR proximal signals, actin movement and B‐cell immune response were determined. Besides, the level of CCR2 in PBMC of SLE patients was analysed by bioinformatics.ResultsCCR2 deficiency reduces the proportion and number of follicular B cells, upregulates BCR proximal signalling and enhances the oxidative phosphorylation of B cells. Meanwhile, increased actin filaments aggregation and its associated early‐activation events of B cells are also induced by CCR2 deficiency. The MST1/mTORC1/STAT1 axis in B cells is responsible for the regulation of actin remodelling, metabolic activities and transcriptional signalling, specific MST1, mTORC1 or STAT1 inhibitor can rescue the upregulated BCR signalling. Glomerular IgG deposition is obvious in CCR2‐deficient mice, accompanied by increased anti‐dsDNA IgG level. Additionally, the CCR2 expression in peripheral B cells of SLE patients is decreased than that of healthy controls.ConclusionsCCR2 can utilise MST1/mTORC1/STAT1 axis to regulate BCR signalling. The interaction between CCR2 and BCR may contribute to exploring the mechanism of autoimmune diseases.
What can occupancy models gain from time‐to‐detection data?
Authors: Priyadarshani Dinusha , Altwegg Res , Lee Alan T. K. , Hwang Wen‐Han 
Published: July 2022

AbstractThe time taken to detect a species during site occupancy surveys contains information about the observation process. Accounting for the observation process leads to better inference about site occupancy. We explore the gain in efficiency that can be obtained from time‐to‐detection (TTD) data and show that this model type has a significant benefit for estimating the parameters related to detection intensity. However, for estimating occupancy probability parameters, the efficiency improvement is generally very minor. To explore whether TTD data could add valuable information when detection intensities vary between sites and surveys, we developed a mixed exponential TTD occupancy model. This new model can simultaneously estimate the detection intensity and aggregation parameters when the number of detectable individuals at the site follows a negative binomial distribution. We found that this model provided a much better description of the occupancy patterns than conventional detection/nondetection methods among 63 bird species data from the Karoo region of South Africa. Ignoring the heterogeneity of detection intensity in the TTD model generally yielded a negative bias in the estimated occupancy probability. Using simulations, we briefly explore study design trade offs between numbers of sites and surveys for different occupancy modeling strategies.
Electrochemical Detection of Artemisinin Using Cobalt Sulphide/Reduced Graphene Oxide Nanocomposite
Authors: Kwabena Adu Darko , Nate Zondi , Alake John , Wisdom Ike Blessing , Chauhan Ruchika , Karpoormath Rajshekhar 
Published: July 2022

AbstractSolvothermally synthesized cobalt sulphide/reduced graphene oxide (CoS/rGO) was used to fabricate an electrochemical sensor for detection of artemisinin. Microscopic techniques were used to characterize CoS/rGO nanocomposite. The electrochemical sensor was fabricated by modifying the surface of glassy carbon electrode with CoS/rGO nanocomposite. [Fe(CN)6]3−/4− was used as a mediator to aid oxidation of artemisinin. Differential pulse voltammetric technique was used for the detection of artemisinin. A linear range of 30–100 μM was used. Experimentally, a detection limit of 0.5 μM was obtained. Therefore, the developed sensor can be used for quality control of artemisinin.