bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Interactive Viewer to Improve Operational Aftershock Forecasts
Authors: Paris Gabrielle M. , Michael Andrew J. 
Published: November 2022

AbstractThe U.S. Geological Survey (USGS) issues forecasts for aftershocks about 20 minutes after most earthquakes above M 5 in the United States and its territories, and updates these forecasts 75 times during the first year. Most of the forecasts are issued automatically, but some forecasts require manual intervention to maintain accuracy. It is important to identify the sequences whose forecasts will benefit from a modified approach so the USGS can provide accurate information to the public. The oaftools R package (Paris and Michael, 2022) includes functions that analyze and plot earthquake sequences and their forecasts to identify which sequences require such intervention. The package includes the Operational Aftershock Forecast (OAF) Viewer, which incorporates the functions into an interactive web environment that can be used to explore aftershock sequences. The OAF Viewer starts with a global map and table of mainshocks. After a mainshock has been selected, the map and a new table show its aftershocks and the OAF Viewer generates five analytical plots: (1) magnitude–time, which is used to look for patterns in the data; (2) cumulative number, to see how the productivity of the sequence compares to a Reasenberg and Jones (1989) aftershock model over time; (3) magnitude–frequency, to compare the ratio of large to small magnitudes and extrapolate to higher magnitudes with sparse data and lower magnitudes with incomplete data; (4) forecast success, to compare the forecasts with observations for a sequence; and (5) parameter–time, which examines the temporal evolution of the forecast model parameters. The user can interact with the functions provided by the oaftools package through the OAF Viewer or by incorporating the functions into their own analysis methods. The OAF Viewer will help seismologists understand complexities in the data, communicate with the public and emergency managers, and improve the OAF system by maintaining operational awareness.
The study of co-morbid conditions in various stages of chronic kidney disease
Authors: Mullangi Susritha , Durga Prasanna Sabharapu L V , Pratyusha Raj Midde , Varre Mounika 
Published: November 2022

Chronic kidney disease (CKD) is a global health problem affecting 10% of the adult population worldwide. In CKD, Multimorbidity is common which mainly includes hypertension (HTN), diabetes mellitus (DM) and cardiovascular diseases. So, there is a need to find out the effect of multi-morbidity on renal outcomes. The main objective is to study the impact of comorbidities on renal outcomes. Overall 80 patients with comorbidities were enrolled in the study. The Study was conducted in inpatients with CKD of General Medicine department of age greater than 30 years of both genders were included. Hypertension and CKD have a high prevalence amongst the population with stage 3-5 CKD in our study. As per our study Diabetes is the most common cause of End Stage Renal Disease (ESRD). This study shows higher prevalence of CKD among males (61.25%) than females (38.75%). This cross-sectional study estimated that prevalence of CKD is highest among 40-49 years (32.5%) and lowest among &#62;70 years (11.25%). There is significant association between smoking and CKD. Our study revealed that patients with Diabetes and HTN who are found to have proteinuria are very likely to have CKD. Our study suggested that early detection and management of underlying causes may help to slow down the progression of CKD. Patients with multi-morbidity should take care by performing early screening for proteinuria and kidney function tests.
Formulation and evaluation of guava leaf extract gel for mouth ulcer management
Authors: Patil Vrushali , Shivsharan Utkarsha , Patil Ravikant 
Published: November 2022

The highlight of this study was preparation of microparticles using the extract of guava leaves which led to novel drug delivery of the herbal extract. The aim of the study was to formulate a microparticles loaded gel for management of mouth ulcer. The microparticles were prepared by solvent evaporation method using the polymer, oil and liquid phase. Then the preparation of gel base was done with incorporation of microparticles. The evaluation of the microparticles and the gel was done. This study is an effort to develop a herbal gel for mouth ulcers offering better compatibility and lesser discomfort. We used Psidium guajava leaf extract microparticles for the preparation of gel. The gel formulations prepared were transparent and homogeneous within the pH range of 6 to 6.8. The formulation showed acceptable spreadability, extrudability and rheological properties. The formulation showed antibacterial effect against Staphylococcus aureus and E coli. Therefore, developed formulations have the potential to treat mouth ulcers. The Psidium gujava leaf extract microparticles loaded gel is a good mucoadhesive gel for mouth ulcer management. Therefore, herbal ingredients can be used for novel drug delivery and make it safe for administration with lesser risk of adverse reactions.
Phytocompounds curcumin, quercetin, and resveratrol modulate lactate pyruvate level in U87 glioma cells
Authors: Debata Priya Ranjan , Sahoo Amrita 
Published: November 2022

Even when there is enough oxygen available, cancer cells meet their energy requirements by increasing glucose intake, glycolysis rate, and lactate generation. Otto Warburg proposed this process, which is known as the Warburg effect. A recent method of drug discovery includes developing medications that interfere with glucose consumption and aerobic glycolysis, or lactate production in cancer cells. Curcumin (C), Quercetin (Q), Ellagic acid (E), and Resveratrol (R) were examined in U87 cells for their ability to induce cytotoxicity at certain concencentrtions, as well as modulate lactate-pyruvate metabolism. All the tested compounds and their combinations such as C+E, C+Q, C+R and Q+R have exhibited, dose-dependent cytotoxic effect against U87 Glioma cells. Besides, the compounds and their the combination (except ellagic acid) have modulated glucose intake, lactate-pyruvate, and NADH/NAD ratio in U87 Glioma cells.: Phytocompounds those modulate cellular metabolism in cancer cells are currently unknown. Our findings imply that the phytocompounds used in the study are involved in cancer cell metabolic reprogramming and have cytotoxic properties. These substances could be used for prevention and treating cancer.
papel da imprensa escrita na defesa do programa de desestatização do Governo Figueiredo (1979-1985)
Authors: Almeida Valesca de Souza 
Published: November 2022

A mídia desempenhou papel significativo na legitimação de propostas econômicas, políticas ou sociais no Brasil do século XX. Este trabalho tem como objetivo demonstrar a atuação da grande imprensa escrita na divulgação e defesa entusiasta do programa de desestatização de empresas colocado em prática pelo último governo da ditadura militar, do general João Baptista Figueiredo. O posicionamento estimulador de tal projeto foi importante na tentativa de construir consensos no sentido da aceitação do diagnóstico através do qual se entende que, para melhorar a economia, seria fundamental diminuir os gastos e enxugar o Estado. Iniciada ainda na ditadura, a defesa destes ideais avançou depois da transição política e pode ser compreendida como uma continuidade entre os regimes.
Growth Performance and Metabolic Changes in Susceptible Mung Bean [Vigna radiata (L.) Wilczek] during Interaction with Rhizoctonia solani and Trichoderma virens
Authors: Inayati A. , Aini L.Q. , Yusnawan E. 
Published: November 2022

Background: Mung bean is susceptible to Rhizoctonia solani infection. Applications of beneficial microorganisms such as Trichoderma are promising for controlling pathogens and promoting plant growth. Methods: This study investigated growth performance and metabolic changes in mung bean seedlings during interaction with R. solani and Trichoderma virens using Gas Chromatography-Mass Spectrometry (GC-MS). Result: Mung bean infected by R. solani caused root rot and wilting. T. virens treatment reduced the disease severity in infected seedlings and promoted mung bean growth. Seventy-eight metabolites were identified in root extracts and dominated by sugars and fatty acids. The sugars, fatty acids and organic acids were significant metabolite groups that changed in response to pathogen infection and/or T. virens treatment. Five metabolic pathways particularly pyruvate metabolism, glyoxylate and dicarboxylate metabolism, sulfur metabolism, citrate cycle (TCA cycle) and phenylalanine, tyrosine and tryptophan biosynthesis altered significantly based on a metabolic pathway analysis. Acetic acid and aconitine had important roles in mung bean response to R. solani infection and/or T. virens treatment.
Participatory as everyday life: from creativity-based initiative to the production of networked space in Southeast Asian cities
Authors: Habibi Zaki 
Published: November 2022

The notion of creative city has been extensively discussed both in academic debate as well as public discourse, including on Asian context. However, a tendency to study only on strategic government policies in relation to this matter has led many multidimensional aspects being left behind. One of these important aspects is the creativity-based activities initiated and conducted by local groups, communities, or collectives on a daily basis apart from so-called the official city programmes. This paper that derives from participatory paradigm takes into account this kind of practice, and seek the meanings of participatory culture as everyday life in urban context. The participatory initiatives discussed inÂ this paper as the empirical cases are â€œTobucil & Klabsâ€ in Bandung, Indonesia and the street arts in George Town, Penang, Malaysia. Considering the current context that participation is getting more mediated (Livingstone, 2013), I employ digital ethnography and documentary photography as the methodological standpoints to understand the digital media practices â€“ i.e. online engagement â€“ that also intertwine with the offline engagement in these two particular cases. I argue, the creativity-based initiatives in these two Southeast Asian cities lead to new insight in understanding media and creativity in current Asia. Additionally, informed by the work of Henri Lefebvre on â€œsocial spaceâ€ and developed it further, I also argue that this certain participatory culture lead to the production of networked space in relation to city identities. This could contribute in forming a new theoretical model in understanding the interplay between media, participation, and urban cultures in digital era.Keywords: City identity, creativity; digital ethnography; digital media; documentary photography; everyday life; networked space; participation; Southeast Asia.
Circular RNA hsa_circ_0007444 inhibits ovarian cancer progression through miR-23a-3p/DICER1 axis
Authors: Zhang Min , Sun Yu , Xu Hanzi , Shi Yaqian , Shen Rong , Teng Fang , Xu Juan , Jia Xuemei 
Published: November 2022

Abstract
Background: Ovarian cancer is the second leading cause of death in women with gynecological malignancy in China. Circular RNAs are a class of noncoding regulatory RNAs reported to be involved in cancer development and progression. Previous studies, including our own, have indicated that hsa_circ_0007444 is downregulated in ovarian cancer tissues. This study aims to elucidate the function and mechanism of hsa_circ_0007444 in ovarian cancer progression.
Methods: The expression of hsa_circ_0007444 is determined by quantitative real-time PCR (qRT-PCR). Cell proliferation, invasion, migration and apoptosis are examined by cell counting-kit 8 (CCK-8), transwell, and flow cytometry assays. Tumor growth and metastasis are assessed in vivo using Balb/c nude mouse xenograft model and tail vein injection model. And the mechanism of action of hsa_circ_0007444 is analyzed by RNA-binding protein immunoprecipitation (RIP), luciferase reporter and rescue assays.
Results: Hsa_circ_0007444 is downregulated in ovarian cancer cell lines compared with normal ovarian epithelial cell line. Gain- and loss-of-function results indicate that hsa_circ_0007444 inhibits cell proliferation, invasion, migration and increases cell apoptosis of ovarian cancer cells in vitro and inhibits the tumor growth and lung metastasis in vivo. Additionally, the results of the bioinformatics analysis, RIP, luciferase reporter and rescue assays confirm that hsa_circ_0007444 can interact with AGO2 and sponge the microRNA miR-23a-3p, thereby upregulating DICER1expression, which is an important tumor suppressor in ovarian cancer.
Conclusions: Hsa_circ_0007444 can inhibit ovarian cancer progression through the hsa_circ_0007444/miR-23a-3p/DICER1 axis.
Determinants of health facility delivery among reproductive age women in low and middle income countries; evidence from most recent demographic health survey: Application of multilevel binary logistic regression model
Authors: Asmare Abebew Aklog , Agmas Yitateku Adugna 
Published: November 2022

Abstract
Background
High prevalence of maternal mortality in LMICs has been attributed to the low patronage of antenatal care and health facility delivery. Childbirth at health facilities is one of the safest ways to prevent maternal morbidity and mortality. The study aims to identify the determinants of health facility of delivery among reproductive age women in LMICs.
Methods
A total weighted sample of 329,721 women who gave birth during the study period was included in the study. Intra-class Correlation Coefficient, Median Odds Ratio, Proportional Change in Variance, AIC, BIC, and deviance were used for model fitness and comparison. Multilevel multivariable logistic regression model was fitted to identify determinants of health facility delivery in LMICs. Adjusted Odds Ratio with its 95% Confidence Interval was used to declare significant determinants of health facility delivery.
Results
The overall prevalence of health facility delivery was 67.6% and this ranged from 19.6% in Chad to 99.8% in Armenia. In the Multilevel multivariable logistic regression model; age less than 20 (AOR = 0.958; 95%CI: 0.928–0.990), age 20 to 34 (AOR = 0.986; 95%CI: 0.957–1.015), rural women (AOR = 0.668; 95%ci: 0.489–0.913), primary educated women (AOR = 1.545; 95%CI: 1.511–1.583), secondary educated women (AOR = 2.145; 95%CI: 2.087–2.206), higher educated women (AOR = 3.362; 95%CI: 3.167–3.570), middle wealth index (AOR = 1.894; 95%CI: 1.859–1.930), rich wealth index (AOR = 2.012; 95%CI: 1.563–2.123), having media exposure (AOR = 1.311; 95%CI: 1.287–1.336), had 4 and more antenatal care visit (AOR = 2.402; 95%CI: 2.360–2.446), unemployed women (AOR = 0.844; 95%CI: 0.843–0.846), and being Western Africa resident (AOR = 0.103; 95%CI: 0.058–0.181) were significantly associated with health facility delivery.
Conclusion
Maternal age, place of residence, maternal education level, family size, number of children, wealth index, marital status, and antenatal care visits were significant determinants of health facility delivery in LMICs. These findings will be useful for the government and stakeholders in planning, designing, and implementing appropriate interventions.
WITHDRAWN: Ketamine alleviated blood-brain barrier damage and microglia over-activation induced by SIRS via restricting cecum damage and HMGB1 release
Authors: Deng Bin , Yang Luxi , Wu Huanghui , Huang Ailing , Yang Daowei , Du Hailiang , Guan Ao , Li Liya , Wang Shaoshuang , Duan Na , Zhu Yulin , Wang Rui , Li Shuang , Wang Qiang 
Published: November 2022

Abstract
Following systemic inflammatory response syndrome (SIRS), the brain is one of the most sensitive organs vulnerable to an external stressor. According to our previous study, ketamine had a protective effect on alleviating SIRS-associated neuronal necroptosis and cecal epithelial cell necroptosis by inhibiting the RIP1-RIP3-MLKL pathway. In this study, we further provided valid evidence that ketamine could safeguard the integrity of the blood-brain barrier (BBB), modulate microglia over-activation, and prevent neural network damage, resulting in relieving cerebral edema and improving system symptoms significantly. Simultaneously, cecum damage was partly reversed by ketamine intervention, which was attributed to a decrease in circulating high mobility group protein 1 (HMGB1). Interestingly, the result showed less cecum injury and relieved BBB disturbance in Rip3-/- mice. Furthermore, circulating HMGB1 content between Rip3-/- mice and mice with ketamine intervention significantly decreased. Moreover, anti-HMGB1 neutralizing antibody identically reversed BBB damage, indicating that cecum-promoted HMGB1 releases extravagated SIRS and BBB leakage. In addition, we clarified that cecectomy reduced serum HMGB1 release level and alleviated BBB damage and microglial activation. Altogether, our work shed light on the new view about the pathogenesis of SIRS, establishing the connection between cecum damage and BBB damage. Besides, we identified ketamine as a candidate to protect the brain from damage like BBB leakage and microglia over-activation, which attributed to the effect on alleviating cecum damage and decreasing circulation HMGB1 release. Our results provided a new theoretical view and therapeutic target for the application of ketamine in SIRS.
Migration and interaction of tetracycline and heavy metals on goethite-coated sand under dynamic flow conditions
Authors: Liu Si-Jia , Zeng De-Hua , Yang Chen , Dang Zhi , Ma Xiao-Yan 
Published: November 2022

Abstract
The antibiotic tetracycline (TC) can easily form intricate complexes with metal ions in the environment because it contains electron donor groups, which affect its environmental behavior. Based on static adsorption and desorption with the aid of column experiments, the migration and interaction of TC and metals (i.e., Cu and Cd) on goethite-coated sand (GCS) were investigated. Furthermore, the interaction between both pollutants was analyzed. A comparison of the migration behavior of TC and heavy metals on the GCS column showed that with increasing pH, TC migration increased. However, the migration of heavy metals decreased, which was mainly related to their hydrolysis. Heavy metals inhibited the migration of TC in the GCS column (the inhibitory effect of Cu was stronger than that of Cd), which was related to the stronger complexation of Cu. Similarly, TC also inhibited Cu migration on the GCS column, and the inhibitory effect was enhanced with increasing pH. At pH 3.0, TC had little effect on the migration of Cd, while at pH 5.5 and pH 8.0, the complexation of TC and Cd and their migration characteristics in GCS column enhanced Cd migration. This study contributes to a better understanding and prediction of the fates of antibiotics and heavy metals in the soil environment under complex contamination conditions. A theoretical basis for environmental risk assessment is also provided.
Percent Fluid Overload for the Prediction of the Need for Fluid De-resuscitation in Critically Ill Patients: A Single-Centre Prospective Cohort Study
Authors: Alharbi Reham , Aldardeer Namareq , Heaphy Emily , Alabbasi Ahmad , Albuqami Amjad , Hawa Hassan 
Published: November 2022

Abstract

Background: Positive fluid balance (FB) was reported in up to 40% of patients admitted to the ICU. Many studies found that positive FB is associated with increased mortality. The appropriate time for fluid de-resuscitation (DER) is controversial. This study aims to evaluate the association between percent fluid overload calculation and the need for fluid de-resuscitation among critically ill adult patients.
Methods: A Prospective observational study was conducted at a single-center tertiary care hospital. The study included adult critically ill patients requiring intravenous fluid administration. Patients who were de-resuscitated with diuretics and/or renal replacement therapy were compared to those who did not require de-resuscitation. The study compared both groups for the median percent fluid accumulation on the day of fluid de-resuscitation or ICU discharge, whatever comes first.
Results: Three hundred eighty-eight patients were screened between August 01, 2021, and April 30, 2022. One hundred patients were included with a mean age of 59.8 ± 16.2. The mean APACHE II score was 15.4 ±8.0. Sixty-one patients (61%) required fluid de-resuscitation, while 39 (39%) patients didn't require fluid de-resuscitation during ICU stay. Median percent fluid accumulation on the day of de-resuscitation or ICU discharge was 3.8% (1.2-8.6) and 5.3% (2.7-8.6) in patients requiring de-resuscitation and those who did not, respectively (P-value NS). Hospital mortality was found in 25 (40.9%) patients with de-resuscitation and 6 (15.3%) in those who did not require it; (P-value 0.0069).
Conclusions: The median percent fluid accumulation on the day of fluid de-resuscitation or ICU discharge was not statistically different between patients who required fluid de-resuscitation and those who did not. A larger sample size is needed to confirm these findings.
Epidemiological Profile of Patients With Cerebral Palsy at a Dental Reference Service
Authors: Barbagelata Vania Regina Melo , Balbinot Karolyny Martins , Pinheiro Helder Henrique Costa , Kataoka Maria Sueli da Silva , Pinheiro João de Jesus Viana , Junior Sérgio de Melo Alves 
Published: November 2022

Abstract
Background: cerebral palsy (CP) is the most common cause of severe physical disabilities in childhood and affects about 17 million people worldwide, the aim of this study is to examine both medical and dental profiles of CP patients treated at a referral dental care center for patients with special needs and to identify the main risk factors involved in this neurological disorder.
Methods: an observational epidemiological analysis of 284 medical and dental records of patients with CP treated between 1995 and 2019 in a referral dental care center was performed. Statistical analyzes were performed to determine the association between risk factors and CP type, the relation between anoxia and home birth delivery, and the relation between the type of dental treatment and some variables (gender, age range, cognitive deficit, epilepsy, and CP type).
Results:the majority of CP patients were males (59.86%) and spastic was the most prevalent specified CP (40.14%). Premature birth was the only risk factor significantly associated with spastic CP (p=0.002). The high prevalence of perinatal anoxia (41.90%) indicated its relation to home birth delivery (p=0.0017). The cognitive deficit was the most prevalent comorbidity (72.40%). The majority of patients that attended the referral dental care center for the first dental appointment were older than 11 years of age (40.63%) and patients with spastic CP received the highest number of invasive treatments (41.07%).
Conclusions: the medical and dental profiles of patients with CP treated at a referral dental care center for patients with special needs highlighted premature birth as an important risk factor and the unprecedented significant association between perinatal anoxia and home birth delivery. Moreover, comorbidities associated with CP lead to more invasive treatments.