bluuebunny/crossref_metadata_2025_split huggingface dataset:
A notable Gamma‐Lindley first‐order autoregressive process: An application to hydrological data
Authors: Mello Alice B. V. , Lima Maria C. S. , Nascimento Abraão D. C. 
Published: March 2022

AbstractA new Gamma‐Lindley (GaL) first‐order autoregressive process (AR) is introduced, called GaL‐AR(1). The distribution for the GaL‐AR(1) innovation process and some of its structural properties are derived, such as the Laplace transform for its bivariate distribution, the conditional variance and expected value, and the spectral and autocorrelation functions. We propose two different estimation procedures whose asymptotic properties are studied by Monte Carlo experiments. An application to actual data from hydrology is performed. Results point out that our process outperforms other six non‐Gaussian AR(1) models that are well defined in the time series literature.
TMU‐24 (Zn‐based MOF) as an advance and recyclable adsorbent for the efficient removal of eosin B: Characterization, equilibrium, and thermodynamic studies
Authors: Samimi Mohsen , Safari Meysam 
Published: March 2022

AbstractZn‐based TMU‐24 as a metal–organic framework (MOF), containing amide‐functionalized pores was prepared by a facile and efficient strategy. The obtained TMU‐24 was illustrated to be efficient adsorbents for the eosin B removal from an aqueous solution. Due to their large surface area, stability, tunability, and porosity of the TMU‐24, as well as π–π and hydrophobic interactions, hydrogen bonding formation between the dye and the MOF ligands, the fabricated sorbents showed fast adsorption kinetics (9 min) and high adsorption capacity. The effect of important factors such as pH, amount of adsorbent, contact time, and desorption conditions to achieve the optimal removal conditions was investigated. The optimum condition was pH = 6, absorbent dosage 4 mg and contact time 9 min. The adsorption results match with those of the Langmuir model and the pseudo‐second‐order kinetics, suggesting that eosin B was adsorbed to the adsorbent in monolayers due to its chemical affinity. The maximum adsorption capacity of TMU‐24 for the removal of eosin B was 370.37 mg/g. Thermodynamic parameters suggested that the adsorption procedure is spontaneous and exothermic. TMU‐24 exhibited excellent reusability (6 cycles) and had potential in the treatment of dyes polluted wastewater.
The offloading algorithm of mobile edge computing considering mobility in the intelligent inspection scenario
Authors: Xie Yue , Sun Yongyong , Xu Fei , Zhang Zhuoya , Qin Zengshi 
Published: March 2022

AbstractIn industrial scenarios, it is very common to replace manual detection with new intelligent applications such as image recognition based on deep learning. However, these applications often have the characteristics of high computational energy consumption and high computational density. It is impossible to deal with these tasks only by relying on intelligent detection equipment. Mobile edge computing (MEC) is an effective method to solve the problems of high energy consumption and insufficient computing power of detection equipment. A reasonable offloading strategy can reduce equipment energy consumption and reduce system maintenance costs. This article studies the intelligent inspection scenarios of multi‐user and multi‐MEC servers, and considers the resource competition and mobility among users. We divided the entire inspection process into several computing cycles, and designed a mobile migration model based on the traditional computing offloading model. Finally, a distributed algorithm based on game theory is proposed to solve the problem of minimizing energy consumption. The proposed intelligent inspection and offloading migration algorithm is evaluated through simulation experiments. Theoretical and experimental results show that our method can better adapt to the scenario proposed in this article, with low algorithm complexity and can effectively reduce the energy consumption of the whole inspection system. Compared with random and greedy algorithms, the energy consumption is reduced by 60% and 50% respectively.
The effects of docosahexaenoic acid supplementation on cognition and well‐being in mild cognitive impairment: A 12‐month randomised controlled trial
Authors: Mengelberg Alexia , Leathem Janet , Podd John , Hill Stephen , Conlon Cathryn 
Published: March 2022

AbstractObjectivesSeveral recent clinical trials have shown that docosahexaenoic acid (DHA) supplements have a significant effect on cognition in cognitively impaired older adults. This randomised controlled trial aimed to investigate the cognitive effects of a DHA fish oil supplement in older adults with mild cognitive impairment, and to examine the moderating effect of the apolipoprotein E (APOE) ɛ4 allele on cognition and well‐being.Methods/DesignSeventy‐two older adults between the ages of 60 and 90 from New Zealand were given a DHA supplement equivalent to 1491 mg DHA + 351 mg eicosapentaenoic acid per day or a placebo for a period of 12 months. Outcome measures included cognition, wellbeing and self‐rated quality of life as well as height, weight, blood pressure and APOE genotyping.ResultsThe final analysis (n = 60) found no evidence of a treatment effect on cognitive measures, although did find a treatment effect on systolic blood pressure (p = 0.03, ƞ2 = 0.08), and a treatment interaction for APOE ɛ4 carriers on depression (p = 0.04, ƞ2 = 0.07) and anxiety (p = 0.02, ƞ2 = 0.09) scores in favour of the DHA supplement.ConclusionsDespite no effect on cognition, the positive result in APOE ɛ4 carriers on depression and anxiety scores and on systolic blood pressure justifies further DHA trials. It may be a prudent step going forward for more studies to replicate the design elements (dose, duration and cognitive measures) of previous DHA trials to help understand why not all older adults appear to benefit from taking a fish oil supplement.
The effect of acquisition duration on cerebral blood flow‐based resting‐state functional connectivity
Authors: Nakamura Yuko , Uematsu Akiko , Okanoya Kazuo , Koike Shinsuke 
Published: March 2022

AbstractResting‐state functional connectivity (rs‐FC) is widely used to examine the functional architecture of the brain, and the blood‐oxygenation‐level‐dependent (BOLD) signal is often utilized for determining rs‐FC. However, the BOLD signal is susceptible to various factors that have less influence on the cerebral blood flow (CBF). Therefore, CBF could comprise an alternative for determining rs‐FC. Since acquisition duration is one of the essential parameters for obtaining reliable rs‐FC, we investigated the effect of acquisition duration on CBF‐based rs‐FC to examine the reliability of CBF‐based rs‐FC. Nineteen participants underwent CBF scanning for a total duration of 50 min. Variance of CBF‐based rs‐FC within the whole brain and 13 large‐scale brain networks at various acquisition durations was compared to that with a 50‐min duration using the Levene's test. Variance of CBF‐based rs‐FC at any durations did not differ from that at a 50‐min duration (p > .05). Regarding variance of rs‐FC within each large‐scale brain network, the acquisition duration required to obtain reliable estimates of CBF‐based rs‐FC was shorter than 10 min and varied across large‐scale brain networks. Altogether, an acquisition duration of at least 10 min is required to obtain reliable CBF‐based rs‐FC. These results indicate that CBF‐based resting‐state functional magnetic resonance imaging (rs‐fMRI) with more than 10 min of total acquisition duration could be an alternative method to BOLD‐based rs‐fMRI to obtain reliable rs‐FC.
Efficient silencing of hepatitis B virus S gene through CRISPR‐mediated base editing
Authors: Zhou Hao , Wang Xiaomei , Steer Clifford J. , Song Guisheng , Niu Junqi 
Published: March 2022

Abstract
Hepatitis B virus (HBV) infection is a major risk factor of liver cirrhosis and hepatocellular carcinoma. Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated protein 9 (Cas9) has been used to precisely edit the HBV genome and eliminate HBV through non‐homologous end‐joining repair of double‐stranded break (DSB). However, the CRISPR/Cas9‐mediated DSB triggers instability of host genome and exhibits low efficiency to edit genome, limiting its application. CRISPR cytidine base editors (CBEs) could silence genes by generating a premature stop codon. Here we developed a CRISPR base editor approach to precisely edit single nucleotide within the HBV genome to impair HBV gene expression. Specifically, a single‐guide RNA (sgRNA) was designed to edit the 30th codon of HBV S gene, which encodes HBV surface antigen (HBsAg), from CAG (glutamine) to stop codon TAG. We next used human hepatoma PLC/PRF/5 cells carrying the HBV genome to establish a cell line that expresses a CBE (PLC/PRF/5‐CBE). Lentivirus was used to introduce sgRNA into PLC/PRF/5‐CBE cells. Phenotypically, 71% of PLC/PRF/5‐CBE cells developed a premature stop codon within the S gene. Levels of HBs messenger RNA were significantly decreased. A 92% reduction of HBsAg secretion was observed in PLC/PRF/5‐CBE cells. The intracellular HBsAg was also reduced by 84% after treatment of gRNA_S. Furthermore, no off‐target effect was detected in predicted off‐target loci within the HBV genome. Sequencing confirmed that 95%, 93%, 93%, 9%, and 72% S gene sequences of HBV genotypes B, C, F, G, and H had the binding site of sgRNA. Conclusion: Our findings indicate that CRISPR‐mediated base editing is an efficient approach to silence the HBV S gene, suggesting its therapeutic potential to eliminate HBV.
Traumatic spinal cord injury caused by a dagger in the spine: A case report
Authors: Zhou Hong‐Su , Pi Yu , Wang Chong , Ao Jun , Sun Lv , Yuan Hao 
Published: March 2022

AbstractAcute traumatic spinal cord injury (SCI) combined with foreign matter retention is rare in the clinic, which causes less literature reported, browsed, and analyzed. A 36‐year‐old male was rushed to our institution due to an attack on the back. His superficial sensation below the nipple had disappeared (mainly in the left breast), the proprioception of both lower limbs was obviously decreased, and the muscle strength of the left lower limb was level 0 and that of the right lower limb was level 3. Computed tomography of the thoracic vertebrae showed that the dagger had completely pierced into the T9 vertebral body and the spinal canal. Prehospital transport: the spinal cord may be injured again due to the movement of the remaining foreign matter and the posture of the patients while they are being transported. Pathophysiology: the incidence of incomplete SCI is higher than that of other types of SCI. Imaging examination: magnetic resonance imaging might cause unexpected secondary injuries. Treatments: surgical intervention including removal of foreign matter and decompression is an essential and important measure for recovery of neurological function. Patients could benefit from administration of methylprednisolone.
Influencing factors on ecological efficiency: Based on 11 cities in Zhejiang Province, China
Authors: Huang Lizhen , Zhang Yixiang , Hong Zhenjie , Xu Xu 
Published: March 2022

Abstract
Ecological efficiency (eco-efficiency) is the effectiveness of ecological resources in meeting human needs and is a good representation of the quality of a region's development. The traditional concept of improving eco-efficiency refers to maximizing economic benefits by minimizing resource costs and environmental loads. This article argues that the goal of eco-efficiency evaluation is not only to maximize economic benefits but also to achieve high-quality and coordinated development in many aspects so that more people can enjoy the fruits of development. Therefore, in the evaluation system of eco-efficiency, the input indexes take into account the consumption of human, energy resources, and the environmental load caused by them in a region. The output indexes take into account the four dimensions of “economy, innovation, social harmony, and openness.” This study first establishes the nonexpected output superefficiency slacks-based measure model under the assumption of variable returns to scale to measure eco-efficiency in 11 cities of Zhejiang Province, China. Second, the spatial and temporal trends of eco-efficiency are studied with the help of the Malmquist index model. Moreover, regression analysis was conducted using the panel Tobit method to discuss the influencing factors of eco-efficiency. Several key results were obtained in this study: (1) The overall eco-efficiency in Zhejiang Province is rising steadily, but there are serious regional imbalances. (2) The improvement of eco-efficiency mainly relied on the scale efficiency from 2008 to 2013, but on pure technical efficiency from 2013 to 2018. (3) The share of tertiary industry, the number of scientific researchers, and the foreign trade dependence positively affect the improvement of eco-efficiency, but highway transportation mileage has a negative impact on the improvement of eco-efficiency. Integr Environ Assess Manag 2023;19:139–151. © 2022 SETAC
Endogenous sex hormones, aromatase activity and lung cancer risk in postmenopausal never‐smoking women
Authors: Zhao Yingya , Gao Yu‐Tang , Zhang Xianglan , Rockwood Alan L. , Kushnir Mark M. , Cai Qiuyin , Wu Jie , Shi Jiajun , Lan Qing , Rothman Nathaniel , Shyr Yu , Shu Xiao‐Ou , Zheng Wei , Yang Gong 
Published: March 2022

AbstractAlthough reproductive factors have been repeatedly associated with lung cancer risk, no study to date has directly evaluated the relationship with endogenous sex hormones nor with aromatase activity in postmenopausal never‐smoking women. A case‐control study of 397 incident lung cancer cases and their individually matched controls, nested within the Shanghai Women's Health Study, was conducted among postmenopausal women who were lifetime never smokers. Prediagnostic concentrations of sex hormones was quantitated using LC‐MS/MS assays in plasma. The product‐substrate molar ratio of estrone to androstenedione was used as an index of aromatase activity (IAA). Multivariable conditional logistic regression models were used to calculate odds ratios (ORs) for lung cancer. Baseline concentrations of estradiol, free testosterone and IAA were inversely associated with subsequent risk of lung cancer in multivariable‐adjusted models. When further adjusted for body mass index, the inverse association with estradiol was attenuated and no longer statistically significant, but the association with free testosterone and IAA remained. In analyses confined to participants having never used menopausal hormone therapy in 376 case‐control pairs, the inverse association with free testosterone and IAA was slightly strengthened. OR for the highest vs the lowest quartile of free testosterone was 0.55 (95% CI = 0.34‐0.90; Ptrend = .03), and the corresponding OR for IAA was 0.57 (95% CI = 0.34‐0.96; Ptrend = .04). Our study, for the first time, suggests that higher levels of circulating free testosterone and estimated aromatase activity may be associated with lower lung cancer risk in postmenopausal never‐smoking women.
Trajectories of loneliness across adolescence: An empirical comparison of longitudinal clustering methods using R
Authors: Verboon Peter , Hutten Elody , Smeekens Sanny , Jongen Ellen M. M. 
Published: March 2022

AbstractIntroductionIn this study, we compare three different longitudinal clustering methods. As a case study, the comparison of the methods is conducted for the development of loneliness from middle childhood to young adulthood. The aim is to explore how two nonparametric longitudinal cluster methods compare with a model‐based latent class mixture model approach.MethodsThe trajectories of loneliness of 130 young people between 9 and 21 years of age, were analyzed to find a set clusters within these trajectories. The data for this study were obtained from the Nijmegen Longitudinal Study on Infant and Child Development (The Netherlands). Loneliness was measured at four waves at the age of 9, 13, 16, and 21 years. The nonparametric methods are in the R‐packages kml and traj, and the model‐based in the lcmm package.ResultsAll methods indicated that the optimal number of clusters to describe the heterogeneity across the trajectories was three. The kml and lcmm methods showed the most similarity in shape of all clusters and fitted the data relatively well, while the traj method yielded somewhat different shapes and didn't fit the data well.ConclusionsAll three methods corroborate the literature in this field by finding that the largest portion of subjects experience stable and low levels of loneliness. However, the clustering methods also reveal that there is a portion of subjects that experience changes in loneliness during adolescence. By comparing the results of nonparametric clustering methods to the latent class mixture model, this study equips researchers with an example of how to implement these models and thereby contributes to the literature on longitudinal clustering in the social sciences. Altogether the analyses show that it might be useful to investigate different algorithms to identify the most robust solution.
Spectroscopic optical coherence tomography for classification of colorectal cancer in a mouse model
Authors: Kendall Wesley Y. , Bordas Julianna , Mirminachi Seyedbabak , Joseph Abel , Roper Jatin , Wax Adam 
Published: March 2022

AbstractNoninvasive diagnosis of the malignant potential of colon polyps can improve prevention of colorectal cancer without the need for time‐consuming and expensive biopsies. This study examines the use of spectroscopic optical coherence tomography (OCT) to classify tissue from genetically engineered mouse models of early‐stage adenoma (APC) and advanced adenocarcinoma (AKP) in which tumors are induced in the distal colon. The optical tissue properties of scattering power and scattering attenuation coefficient are evaluated by analyzing the imaging data collected from tissues. Classifications are generated using 2D linear discriminant analysis with high levels of discrimination obtained. The overall classification accuracy obtained was 91.5%, with 100% sensitivity and 96.7% specificity in separating tumors from benign tissue, and 77.8% sensitivity and 99.4% specificity in separating adenocarcinoma from nonmalignant tissue. Thus, this study demonstrates the clinical potential of using spectroscopic OCT for rapid detection of colon adenoma and colorectal cancer.
Muscle architecture and clinical parameters in stroke patients: An ultrasonographic study
Authors: Onat Şule Şahin , Polat Cemile Sevgi , Gürçay Eda , Özcan Didem Sezgin , Orhan Ali 
Published: March 2022

AbstractPurposeTo compare the lower extremity muscle architecture on both the affected side and healthy sides using ultrasound (US) imaging and examine the relationship between these measurements and clinical parameters in stroke patients.MethodsA cross‐sectional analysis of 125 stroke patients (64 M, 61 F) was performed in this study. Timed up and go (TUG) test was used to evaluate balance, Fugl‐Meyer assessment of lower extremity (FMA‐LE) was used to evaluate motor function, functional independence measurement (FIM) was used to evaluate functional status. Muscle thicknesses (MT) of rectus femoris (RF), vastus intermedius (VI), vastus medialis (VM), vastus lateralis (VL), soleus, medial gastrocnemius (GC) muscles, the PA and the FL of GC were obtained using ultrasound (US) imaging.ResultsThe muscle thickness, PA and FL of the affected side decreased significantly compared to the healthy side (p = .0001) in stroke patients. Another clear result was that soleus and GC muscle thicknesses and PA of GC muscle were found to be associated with balance, motor function, and functional status.ConclusionThe properties of muscles evaluated with US may provide recommendations for clinical assessments and also potentially contribute to clinicians designing a rehabilitation intervention program for stroke patients.
Protective effect of Celastrus paniculatus on cognitive function in glutamate‐induced brain‐injured mice by reducing the intracellular influx of Ca+
Authors: John Elezabeth , Mishra Bharat , Tripathi Alok Shiomurti , Aleesha R. 
Published: March 2022

AbstractPresent investigation evaluates the protective effect of Celastrus paniculatus (CP) on the cognitive function in neuronal injured mice. Neuronal injury was induced by oral administration of monosodium glutamate (MSG) at a dose of 1.66 g/kg/day for 30 days. Mice in the CP‐treated group receives CP 30 mg/kg ip and CP + GGA‐treated group received CP 30 mg/kg ip and glutamic acid (GGA, 1.5 mg/kg, ip) 30 min prior to the administration of MSG for 30 days. Assessment of cognitive function was done using Morris water maze. Level of inflammatory cytokines and production of reactive oxygen species (ROS) was estimated in the brain tissue of brain‐injured mice. Moreover, intracellular concentration of Ca+ ion was estimated in the brain tissue and expression of Bcl‐2, Bax, and caspase‐3 protein was estimated in the brain tissue by western blot assay. Cognitive function was attenuated in CP‐treated glutamate‐injured mice. Data of the study suggest that treatment with CP reduces the level of inflammatory cytokines and production of ROS in the brain tissue compared to negative control group. There was reduction in the concentration of Ca+ ion in the neuronal cells in CP‐treated group than negative control group of mice. Treatment with CP ameliorates the expression of Bax, Bcl‐2, and caspase‐3 in the brain tissue of glutamate‐induced brain‐injured mice. In conclusion, data of the study suggest that treatment with CP attenuates the cognitive function and neuronal apoptosis in glutamate‐induced neuronal injury by reducing the concentration of intracellular Ca+ ion.
Reactivity of pyrimidinylphosphazenes with acetylenic esters: Competitive [4 + 2] and [2 + 2] tandem cycloaddition or retro‐cycloaddition approaches
Authors: Cobo Justo , Molina Sebastián , Sánchez Adolfo , Nogueras Manuel , Insuasty Braulio , Orozco‐López Fabián 
Published: March 2022

AbstractIn the search for new intermediates for heterocyclic synthesis, the reactivity of 6‐iminophosphoranepyrimidines against dimethyl acetylenedicarboxylate (DMAD) and ethyl propiolate as dienophiles, was studied in this work. The presence of a viable 2‐azadienic moiety in pyrimidin‐4‐one rings (oxo derivatives) favored reaction of DMAD by [4 + 2]/retro‐[4 + 2] sequence, in addition to the expected [2 + 2] cycloaddition/retrocycloaddition involving phosphazene moiety. In contrast, pyrimidine derivatives lacking a viable 2‐azadienic residue reacted only through phosphazene group by the aforementioned [2 + 2]/retro‐[2 + 2] tandem process. Ethyl propiolate (non‐symmetric dienophile) proved less reactive in the study, giving rise to undesired side reactions.