bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in quality of care, mortality, suicidal behavior, and readmissions among migrants and Danish-born inpatients with major depressive disorder
Authors: Knudsen Søren Valgreen , Valentin Jan Brink , Norredam Marie , Videbech Poul , Mainz Jan , Johnsen Søren Paaske 
Published: October 2022

Abstract

Background
The increasing global migration has made migrants’ health a pertinent topic. This article aimed to examine whether migrants were less likely than Danish-born residents to receive guideline recommended care when hospitalized for major depressive disorder (MDD) and potential differences in clinical outcomes, including all-cause mortality, suicidal behavior, and readmissions during 1-year follow-up after first-time admission.

Methods
A national cohort study was performed, including all adult MDD inpatients at mental care units in the period 2011–2017. Migrants and two migrant subgroups (non-Western and Western) were compared with Danish-born patients. Quality of care was examined using multivariable Poisson and linear regression models. Clinical outcomes were examined using Cox proportional hazards regression analysis.

Results
Migrant-status was associated with a non-significantly lower chance of receiving high-quality care (relative risk [RR] = 0.93, confidence interval [CI] 0.86:1.01) and lower readmission rates for depression (hazard rate ratio [HR] = 0.93, CI 0.86:1.01), and significantly higher all-cause mortality (HR = 1.55, CI 1.19:2.01) and lower all-cause readmission rate (HR = 0.88, CI 0.83:0.94). No clear association was found regarding suicidal behavior. While associations were comparable for migrant subgroups regarding readmission, the associations with low quality of care and of all-cause mortality appeared strongest among Western migrants.

Conclusions
Among inpatients with MDD in a universal tax-financed healthcare system, being a migrant was associated with a potential lower quality of in-hospital care and worse clinical outcomes. These results warrant further investigation to clarify the underlying explanation for these inequalities and to develop and test interventions to ensure better quality of care and clinical outcomes for migrant patients.
Phase II, Open-Label Study of Ciltacabtagene Autoleucel, an Anti–B-Cell Maturation Antigen Chimeric Antigen Receptor–T-Cell Therapy, in Chinese Patients With Relapsed/Refractory Multiple Myeloma (CARTIFAN-1)
Authors: Mi Jian-Qing , Zhao Wanhong , Jing Hongmei , Fu Weijun , Hu Jianda , Chen Lijuan , Zhang Yiwen , Yao Dan , Chen Diana , Schecter Jordan M. , Yang Fan , Tian Xiaochen , Sun Huabin , Zhuang Sen Hong , Ren Jimmy , Fan Xiaohu , Jin Jie , Niu Ting , Chen Sai-Juan 
Published: October 2022

PURPOSE CARTIFAN-1 aimed to evaluate the efficacy and safety of ciltacabtagene autoleucel (cilta-cel), a B-cell maturation antigen–targeting chimeric antigen receptor T-cell therapy, in Chinese patients with relapsed/refractory multiple myeloma (RRMM). METHODS This pivotal phase II, open-label study (ClinicalTrials.gov identifier: NCT03758417 ), conducted across eight sites in China, enrolled adult patients with RRMM who had received ≥ 3 lines of prior therapy, including a proteasome inhibitor and immunomodulatory drug. Patients received a single infusion of cilta-cel (target dose 0.75 × 106 chimeric antigen receptor–positive viable T cells/kg). The primary end point was overall response rate. Secondary end points included progression-free survival (PFS), overall survival (OS), and incidence and severity of adverse events (AEs). RESULTS As of the clinical cutoff of July 19, 2021, 48 patients received a cilta-cel infusion. At an 18-month median follow-up, the overall response rate was 89.6% (95% CI, 77.3 to 96.5), with a median time to first response of approximately 1 month; 77.1% of patients (95% CI, 62.7 to 88.0) achieved complete response or better. Medians for duration of response, PFS, and OS were not reached. The 18-month PFS and OS rates were 66.8% (95% CI, 49.4 to 79.4) and 78.7% (95% CI, 64.0 to 88.0), respectively. Hematologic AEs were common, including anemia (100%), neutropenia (97.9%), lymphopenia (95.8%), and thrombocytopenia (87.5%). Cytokine release syndrome occurred in 97.9% of patients (35.4% grade 3/4); the median time to onset was 7 days, and the median duration was 5 days. Infections occurred in 85.4% of patients (37.5% grade 3/4). Ten deaths occurred after cilta-cel infusion, eight of which were due to treatment-related AEs. CONCLUSION These data demonstrate a favorable risk-benefit profile for a single infusion of cilta-cel, resulting in early, deep, and durable responses in heavily pretreated patients with RRMM in China.
Landing manoeuvres predict roost-site preferences in bats
Authors: Chaverri Gloriana , Araya-Salas Marcelo , Barrantes Jose Pablo , Uribe-Etxebarria Tere , Peña-Acuña Marcela , Varela Angie Liz , Aihartza Joxerra 
Published: October 2022

ABSTRACT
Roosts are vital for the survival of many species, and how individuals choose one site over another is affected by various factors. In bats, for example, species may use stiff roosts such as caves or compliant ones such as leaves; each type requires not only specific morphological adaptations but also different landing manoeuvres. Selecting a suitable roost within those broad categories may increase landing performance, reducing accidents and decreasing exposure time to predators. We addressed whether bats select specific roost sites based on the availability of a suitable landing surface, which could increase landing performance. Our study focused on Spix's disc-winged bats (Thyroptera tricolor), a species known to roost within developing tubular leaves. As previous studies show that this species relies on the leaves' apex for safe landing and rapid post-landing settlement, we predicted that bats would prefer to roost in tubular structures with a longer apex and that landing would be consistently more effective on those leaves. Field observations showed that T. tricolor predominantly used two species for roosting, Heliconia imbricata and Calathea lutea, but they preferred roosting in the former. The main difference between these two plant species was the length of the leaf's apex (longer in H. imbricata). Experiments in a flight cage also showed that bats used more consistent approach and landing tactics when accessing leaves with a longer apex. Our results suggest that landing mechanics may strongly influence resource selection, especially when complex manoeuvres are needed to acquire those resources.
Ontogeny of the middle ear and auditory sensitivity in the Natterjack toad (Epidalea calamita)
Authors: Lauridsen Tanya Bojesen , Christensen-Dalsgaard Jakob 
Published: October 2022

ABSTRACT
In most anuran amphibians, acoustic communication is of prime importance for mate localization and selection. The tympanic middle ear increases auditory sensitivity and directionality and is therefore expected to be favoured by natural selection. However, especially within the family of true toads (Bufonidae) there is a tendency for species to lose parts of the middle ear apparatus and consequently have a reduced sensitivity to high-frequency sounds (above 1 kHz). Part of the explanation for this may be that development of the middle ear is especially slow in bufonids, and thus the middle ear would be more likely to be lost or non-functional in paedomorphic species. However, a timeline of development of the middle ear has not been established previously. The goal of the present study was to investigate middle ear development in a toad species that has a well-known natural history and acoustic communication behaviour. We made a detailed study of anatomy and biophysics of the middle ear with measurements of auditory sensitivity across age in post-metamorphic natterjack toads (Epidalea calamita). The tadpoles and toadlets were raised in the laboratory, so their exact age was known, their auditory sensitivity was measured using auditory brainstem responses, and middle ear development and function were assessed by anatomical studies and laser vibrometry. We found that the developmental stage of the middle ear depends on the size of the toad rather than its age. The middle ear was functional at the earliest at a snout–vent length of 40 mm, which for these toads was around 500 days post-metamorphosis, close to the time of first reproduction. The functional, adult-like middle ear was shown to have 30 dB increased sensitivity to the dominant frequency of the mating call compared with sensitivities measured in newly metamorphosed individuals.
Force loss induced by inhibiting cross-bridge cycling is mitigated in eccentric contraction
Authors: Fukutani Atsuki , Kunimatsu Shiho , Isaka Tadao 
Published: October 2022

ABSTRACT
We examined whether the force loss induced by 2,3-butanedione monoxime affects isometric and eccentric forces differently. Single skinned muscle fibers were activated at an average sarcomere length of 2.4 μm and then stretched to 3.0 μm. This trial was performed with and without 2,3-butanedione monoxime to calculate the magnitude of force loss attained at several time points: pre-stretch phase at 2.4 μm, eccentric phase, end of eccentric contraction, and post-stretch phase at 3.0 μm. The magnitude of force loss was significantly larger in the pre-stretch phase than at the other time points. Further, the mitigated force loss in the eccentric contraction was more prominent in the long condition than in the short condition. We suggest that the eccentric force is relatively preserved compared with the reference isometric force (pre-stretch) when cross-bridge cycling is inhibited, possibly because of the contribution of the elastic force produced by titin.
A critical discourse analysis of the Quebec media’s portrayal of older adults in residences and long-term care homes pre- and peri-COVID-19
Authors: Archambault Olivia , Lagacé Martine , Fraser Sarah Anne 
Published: October 2022

Background: How we discuss older adults can influence our perceptions of aging and age-related policies, particularly during times of crisis. Ageist discourse in the media impacts how society views older adults and how older adults view themselves. Negative stereotypes have been associated with negative health outcomes and can exacerbate the adverse events faced by older adults during a pandemic. This study examined the Quebec media’s portrayal of older adults living in long-term care (LTC) homes before and during the first wave of COVID-19. Methods: The first confirmed COVID-19 case in Quebec was on 27 February 2020. The Factiva database was searched for newspaper articles that were published three months before (pre) and three months after (peri) the first confirmed case. Articles had to include the terms: older adults, LTC, and/or residence. Articles were excluded if they did not discuss direct or indirect impacts in the lives of people living in LTC (i.e., only discussed statistics of COVID-19 cases). After screening, 208 articles were retained, and critical discourse analysis was conducted. Results: The media discourse regarding older adults in LTC homes revealed a lack of resources (i.e., insufficient staff) and negative health outcomes for older adults (i.e., bed sores) in both the pre- and peri-COVID-19 articles. Negative and positive elements emerged from the peri-COVID-19 discourse, including increased social isolation of those in LTC, government action and advocacy (by health care practitioners and family) to support those in LTC homes. Conclusions: Existing systemic problems were exacerbated by the pandemic and this impacted older adults in LTC homes negatively. Despite this, the peri-COVID-19 discourse suggests meaningful change at the societal and policy levels to improve outcomes for future generations of older adults who reside in LTC homes.
Are the cyst nematode hatching factor eclepins rhizosphere signalling molecules? Solanoeclepin A regulates gene expression in plants
Authors: Vlaar Lieke E. , Galland Marc , Dong Lemeng , Rahimi Mehran , Bouwmeester Harro J. 
Published: October 2022

Background: The eclepins are a group of root-exuded compounds that induce the hatching of cyst nematodes, economically relevant pests for crops such as soybean and potato. From an evolutionary standpoint a beneficial effect of eclepins would be expected for the plant. Methods: To identify this beneficial effect, we analysed the transcriptome of two plant species in response to treatment with an eclepin. One of the eclepins, solanoeclepin A (solA), produced by members of the Solanaceae, was used in this study to treat tomato (Solanum lycopersicum) and Arabidopsis seedlings grown in vitro. Samples were used to call differentially expressed genes (DEGs) using RNAseq and followed by GO term enrichment analysis. Results: RNAseq analysis showed that solA downregulates the immune and hypoxia response, as well as ethylene biosynthesis and signalling, and promotes root growth. This response was particularly strong under N and P deficiency in Arabidopsis. Conclusions: Hence, solA affects gene expression in species it is not produced by. Furthermore, these results suggest that solA prepares the plant for colonization by microorganisms, possibly playing a role in nutrient uptake. Moreover, the change in hypoxia response and ethylene signalling and growth stimulation point toward the induction of an altered root architecture, possibly further improving the plant’s ability to recruit beneficial microbes and absorb nutrients.
The effectiveness of a web-based Dutch parenting program to prevent overweight in children 9–13 years of age: Results of a two-armed cluster randomized controlled trial
Authors: Ruiter Emilie L. M. , Molleman Gerard R. M. , Kleinjan Marloes , Kraiss Jannis T. , ten Klooster Peter M. , van der Velden Koos , Engels Rutger C. M. E. , Fransen Gerdine A. J. 
Published: October 2022

Introduction
Although parental support is an important component in programs designed to prevent overweight in children, current programs pay remarkably little attention to the role of parenting. We therefore developed a web-based parenting program entitled “Making a healthy deal with your child”. This e-learning program can be incorporated into existing overweight prevention programs. The aim of this study was to determine the effectiveness of this e-learning program.

Materials and methods
The effectiveness was examined in a two-armed cluster randomized controlled trial. The participants were 475 parent-child dyads of children 9–13 years of age in the Netherlands who participated in an existing schoolclass-based overweight prevention program. At the school grade level, parents were randomly assigned to either the intervention or the control condition. Measurements were taken from both parents and children at baseline, and 5 and 12 months after baseline. Primary outcomes included the child’s dietary and sedentary behavior, and level of physical activity. Secondary outcomes included general parenting style, specific parenting practices, and parental self-efficacy. Linear mixed effects models and generalized linear mixed effects models were conducted in R.

Results
Intention-to-treat analyses and completers only revealed no significant effects between the intervention and control condition on energy balance-related behaviors of the child and parenting skills after correction for multiple testing. The parents’ mean satisfaction with the e-learning program (on a 10-point scale) was 7.0±1.1.

Conclusions
Although parents were generally satisfied with the parenting program, following this program had no significant beneficial effects regarding the children’s energy balance-related behaviors or the parenting skills compared to the control condition. This program may be more beneficial if used by high-risk groups (e.g. parents of children with unhealthy energy balance-related behaviors and/or with overweight) compared to the general population, warranting further study.
Body composition reference values in Singaporean adults using dual-energy X-ray absorptiometry—The Yishun study
Authors: Soh BaoLin Pauline , Lee Shuen Yee , Wong Wai Yin , Pang Benedict Wei Jun , Lau Lay Khoon , Jabbar Khalid Abdul , Seah Wei Ting , Chen Kexun Kenneth , Srinivasan Sivasubramanian , Ng Tze Pin , Wee Shiou-Liang 
Published: October 2022

Objectives
This study establishes age- and sex-specific reference values for fat mass index (FMI), lean mass index (LMI), appendicular LMI (aLMI), and body fat distribution indices including Android/Gynoid % fat ratio and Trunk/Limb % fat ratio in multi-ethnic Singaporean adults.

Methods
A population-based cross-sectional study using dual-energy X-ray absorptiometry (Hologic Discovery Wi) was carried out to measure whole body and regional fat and lean mass in community-dwelling adults. A total of 537 adults (57.5% women), aged from 21 to 90 years, were recruited from the large north-eastern residential town of Yishun. Age- and sex-specific percentile reference values were generated for FMI, LMI, aLMI, Android/Gynoid % fat ratio and Trunk/Limb % fat ratio using the Lambda–Mu–Sigma method. The relationship between the parameters and age were assessed through the Pearson’s correlation coefficient.

Results
All parameters demonstrated significant correlation with age (p < 0.05) for both men and women, except for LMI in women, with the strength of r ranging from 0.12 (weak correlation) to 0.54 (strong correlation). LMI (r = −0.45) and appendicular LMI (r = −0.54) were negatively associated with age in men while none (r = −0.06) to weak correlation (r = −0.14) were shown in women for the same parameters respectively. The Android/Gynoid % fat ratio and Trunk/Limb % fat ratio were positively related to age for both men (r = 0.37 & 0.43, p < 0.001) and women (r = 0.52 & 0.48, p < 0.001).

Conclusion
We have established DXA-based body composition reference data for the Singapore adult population. These reference data will be particularly useful in geriatric, obesity and oncology clinics, enabling the prescription of appropriate therapy to individuals at risk of morbidity from unfavorable body composition phenotypes. It also adds on to the limited reference database on Southeast Asian body composition.
The clinical efficacy and safety of equipment-assisted intravesical instillation of mitomycin C after transurethral resection of bladder tumour in patients with nonmuscular invasive bladder cancer: A meta-analysis
Authors: Zhou Weijian , Liu Jianping , Mao Dongdong , Hu Changying , Gao Dianjun 
Published: October 2022

Background
This review and meta-analysis aimed to systematically evaluate the clinical efficacy and safety of equipment-assisted intravesical instillation of mitomycin C (MMC) in patients with nonmuscular invasive bladder cancer (NMIBC) after transurethral resection of bladder tumour (TURBT).

Methods
The Embase, PubMed, CNKI, CBM, WANGFANG, VIP, Cochrane Library, and Clinicaltrial.com databases were searched for articles published before April 2022. The experimental group was treated with intravesical instillation of MMC assisted by equipment, including radiofrequency-induced thermochemotherapy, conductive thermochemical therapy, electromotive drug administration, or locoregional hyperthermia. The control group was treated with simple MMC perfusion. The outcomes of interest in the meta-analysis were recurrence, progression, side-effects, gross haematuria, and bladder irritation.

Results
A total of 15 studies that enrolled 1,190 patients were included in the meta-analysis. Compared to that of the control group, device-assisted intravesical instillation of MMC significantly reduced both tumour recurrence (odds ratio [OR] = 0.32, 95% confidence interval [CI] [0.24, 0.42], P <0.00001) and progression (OR = 0.29, 95% CI [0.12, 0.67], P = 0.004). There were no significant differences between the two groups in terms of safety (OR = 1.21, 95% CI [0.66,2.21], P = 0.54), bladder irritation (OR = 1.06, 95% CI [0.72,1.55], P = 0.78), or gross haematuria (OR = 1.11, 95% CI [0.64,1.94], P = 0.72).

Conclusions
Equipment-assisted intravesical instillation of MMC significantly reduced the recurrence and progression of patients with NMIBC who underwent TURBT and improved their quality of life. Given the significant heterogeneity in research quality and sample size among earlier studies, more prospective, multicentre, large sample randomized controlled trials are needed to supplement and verify this in the future.
Comparative performance of public and private primary care service delivery in Malaysia: An analysis of findings from QUALICOPC
Authors: Ong Su Miin , Lim Ming Tsuey , Fah Tong Seng , Kamaliah M. N. , Groenewegen Peter , Sivasampu Sheamini 
Published: October 2022

Introduction
Primary care services are essential in achieving universal health coverage and Malaysia is looking into public-private partnership to overcome resource constraints. The study aims to compare the performance of primary care service delivery dimensions between public and private sector.

Methods
This cross-sectional study used the data from the Malaysian International Quality and Costs of Primary Care (QUALICOPC) study conducted in 2015–2016. The relative performance of each sector in four dimensions was compared using multi-level linear regression by incorporating a dummy variable indicating public sector in the model.

Results
The public sector was shown to have higher performance in comprehensiveness and coordination, while the private sector was better in continuity. There was no significant difference in accessibility. The public primary care services were better in serving primary care sensitive conditions, better informational continuity, and with better skill-mix and inter- and intra- professional relationship. Meanwhile, the private sector was stronger in referral decision making process, specialist feedback and greater out of hours facilities access.

Conclusions
The public and private sectors differ in their strengths, which the government may tap into to strengthen primary care services. Other areas for improvement include seamless care strategies that promote good referral, feedback, and information continuity.