bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy and Safety of Neuronavigation for Minimally Invasive Stabilization in the Thoracolumbar Spine Using Polyaxial Screws-Rod: A Canine Cadaveric Proof of Concept
Authors: Guevar Julien , Samer Eva S. , Precht Christina , Rathmann Justus M.K. , Forterre Franck 
Published: June 2022

Abstract
Objectives The main aim of this study was to evaluate the feasibility of minimally invasive stabilization with polyaxial screws-rod using neuronavigation and to assess accuracy and safety of percutaneous drilling of screw corridors using neuronavigation in thoracolumbar spine and compare it between an experienced and a novice surgeon.
Study Design Feasibility of minimally invasive polyaxial screws-rod fixation using neuronavigation was first performed in the thoracolumbar spine of two dogs. Accuracy and safety of drilling screw corridors percutaneously by two surgeons from T8 to L7 in a large breed dog using neuronavigation were established by comparing entry and exit points coordinates deviations on multiplanar reconstructions between preoperative and postoperative datasets and using a vertebral cortical breach grading scheme.
Results Feasibility of minimally invasive stabilization was demonstrated. For the experienced surgeon, safety was 100% and mean (standard deviation) entry point deviations were 0.3 mm (0.8 mm) lateral, 1.3 mm (0.8 mm) ventral and 0.7 mm (1.8 mm) caudal. The exit points deviations were 0.8 mm (1.9 mm) lateral, 0.02 mm (0.9 mm) dorsal and 0.7 mm (2.0 mm) caudal. Significant difference in accuracy between surgeons was found in the thoracic region but not in the lumbar region. Accuracy and safety improvement are noted for the thoracic region when procedures were repeated by the novice.
Conclusion This proof of concept demonstrates that using neuronavigation, minimally invasive stabilization with polyaxial screws-rod is feasible and safe in a large breed dog model.
Argon Plasma Coagulation in Radiation-induced Proctitis
Authors: Góes Fernanda Machado de Araujo , Ribeiro Rebeca Sadigursky , Portugal Matheus Mascarenhas , Abreu Glicia Estevam de 
Published: June 2022

Abstract
Background Argon plasma coagulation (APC) is a non-tactile ablative therapy that helps to stop rectal bleeding in patients who have developed actinic proctitis after exposure to radiotherapy. This approach seems to be more effective than medications or surgical procedures.
Objective To review the literature to verify the effectiveness of APC in the treatment of patients with actinic proctitis induced by radiation therapies.
Methods A systematic search was conducted on the following databases: MEDLINE/PubMed, LILACS, SCIELO, and the Cochrane Central Register of Controlled Trials. We identified 81 studies, and 5 of them fulfilled the inclusion criteria.
Results In the articles included, a total of 236 patients were evaluated. Most of them were men (67.7%) with a mean age of 66.6 years. Prostate cancer was the main cause of actinic proctitis (67.3%), and control of the bleeding was achieved in 83.3% of the cases, after a mean of 1.67 session of APC. Moreover, 66 patients had complications with the treatment, and rectal pain was the most referred.
Conclusions Argon plasma coagulation is a well-tolerated and effective treatment to control rectal bleeding in patients who underwent radiotherapy, and the number of sessions varies from 1 to 2, according to the case.
Awareness of Polycystic Ovarian Syndrome among College Going Females in Gurgaon: A Cross-Sectional Study
Authors: Jakhar Renuka , Sen Elina Dewanji , Dutt Rohit 
Published: June 2022

Abstract
Objectives Women not only take care of family members, they are also source of power and symbol of progress in a society. At the same time, physical and mental well-being of women relies on healthy lifestyle and adequate reproductive health knowledge. With growing incidence of polycystic ovarian syndrome (PCOS), it is crucial to increase awareness about the disease among women at an early age in life. The present survey investigates awareness level of college going females about PCOS.
Materials and Methods 428 females were recruited from 3 colleges in district Gurgaon, Haryana, India, based on convenience sampling. The respondents filled a self-completion questionnaire containing sociodemographic details, menstrual cycle details, and questions related to PCOS.
Statistical Analysis Descriptive statistics was used to calculate frequency and percentage of variables. Pearson's chi-square test of independence was used to identify factors associated with awareness of PCOS. A p-value of < 0.05 was considered to be statistically significant.
Results The mean ±SD age of respondents was 19.9 ± 1.7 years (range = 18–24 years). Only 78 females (18.22%) had heard about PCOS. Being knowledgeable was significantly associated with mother's education (p = 0.001), length of menstrual cycle (p = 0.022), and family history of PCOS (p < 0.001).
Conclusion The present study indicates awareness of PCOS among college going females was very poor. There is an urgent need of increasing awareness about PCOS among young adult college going females not only for prevention, early diagnosis, and treatment of the disease but also to prevent its long-term consequences.
Avaliação de fatores preditores de infecção na artroplastia primária de joelho e quadril: Um estudo caso-controle
Authors: Falótico Guilherme Guadagnini , Tucunduva Vitor , Brito Gustavo , Durigon Thomas Stravinskas , Arliani Gustavo Gonçalves , Ferreira Gabriel Ferraz 
Published: June 2022

Resumo
Objetivo Avaliar os fatores de risco para infecção articular periprotética após procedimento cirúrgico eletivo de artroplastia primária total de joelho ou quadril.
Métodos Incluem-se no estudo 706 prontuários de pacientes que foram submetidos a artroplastia total primária eletiva de quadril ou joelho entre os meses de janeiro e dezembro de 2018. Utilizou-se a análise multivariada dos fatores preditores de infecção por meio de um modelo de regressão logística. Toda a análise estatística foi realizada no software R.
Resultados A prevalência de infecção de toda a amostra foi de 2,0% (14 casos). A amostra contou com a maioria do gênero feminino (79,6%), com o lado direito afetado (50,6%) e predomínio da artroplastia total de joelho (61,3%). Os fatores de risco significativos (p < 0,05) para a infecção foram: tempo cirúrgico maior do que 120 minutos (p = 0,009) e diagnóstico prévio de diabetes (p = 0,025).
Conclusão Artroplastias totais primárias eletivas de joelho ou quadril possuem maior risco de infecção quando ocorre um tempo prolongado do procedimento cirúrgico (acima de 120 minutos) e quando o paciente possui diagnóstico prévio de diabetes mellitus.
Nível de Evidência IIIB, estudo retrospectivo caso-controle.
Impactos da espera para correção cirúrgica da escoliose idiopática do adolescente e suas repercussões para o Sistema Único de Saúde: Protocolo de revisão sistemática
Authors: Pontes Mariana Demétrio de Sousa , Soeira Thabata Pasquini , Sampaio Mariangela Louzada , Herrero Carlos Fernando Pereira da Silva 
Published: June 2022

ResumoA correção cirúrgica é uma opção efetiva de tratamento para casos de Escoliose Idiopática do Adolescente (EIA) com curvas acima de 45°. No âmbito do Sistema Único de Saúde (SUS), os pacientes avaliados nos centros de referência e com indicação cirúrgica são cadastrados em fila de espera até que o tratamento definitivo possa ser realizado. Um período de espera extenso pode ser prejudicial, do ponto de vista de piora dos sintomas e de aumento do custo de tratamento, além de gerar efeitos negativos na saúde mental e na qualidade de vida do paciente. O presente artigo trata-se do protocolo de uma revisão sistemática que buscará responder o questionamento: “Qual o impacto do tempo de espera para correção cirúrgica da EIA do ponto de vista de custo e qualidade de vida?.” O aperfeiçoamento das ações de saúde pública, na esfera da alta complexidade, inicia-se com o levantamento de informações sobre a situação de saúde de determinada condição. Diante disso, as futuras publicações provenientes deste protocolo poderão servir como subsídio para apontar possíveis critérios de prioridade, com o intuito de promover melhoria tanto no âmbito da saúde global de portadores de EIA, quanto na gestão financeira da saúde pública brasileira.
Study of the water dynamics near hydrophilic, nanostructured CuO surfaces by quasielastic and inelastic neutron scattering
Authors: Torres James R. , Buck Zachary N. , Kaiser Helmut , Mamontov Eugene , Tyagi Madhusudan , Hansen Flemming Y. , Herwig Kenneth W. , Daemen Luke , Kidder Michelle K. , Taub Haskell 
Published: June 2022

We have used quasielastic and inelastic neutron scattering to investigate the structure, dynamics, and phase transitions of water interacting with superhydrophilic CuO surfaces that not only possess a strong affinity for water but also a “grass-like” topography that is rough on both micro- and nanoscales. Here, we report quasielastic neutron scattering (QENS) measurements on two samples differing in water content at five temperatures below 280 K. The QENS spectra show water undergoing two different types of diffusive motion near the CuO surfaces: a “slow” translational diffusion occurring on a nanosecond time scale and a faster rotational motion. Further from the surfaces, there is “fast” translational diffusion comparable in rate to that of bulk supercooled water and the rotational motion occurring in the interfacial water. Analysis of the QENS spectra supports wetting of water to the CuO blades as seen in electron microscopy images. In addition, we observe an anomalous temperature dependence of the QENS spectra on cooling from 270 to 230 K with features consistent with a liquid–liquid phase transition. We suggest that the solvent-like properties of the coexisting bulk-like water in our CuO samples are a significant factor in determining the temperature dependence of the interfacial water’s dynamics. Our results are compared with those obtained from two well-studied substrate classes: (1) silicas that contain ordered cylindrical nanopores but have weaker hydrophilicity and (2) nanoparticles of other transition-metal oxides, such as TiO2, which share the strong hydrophilicity of our samples but lack their porosity.
Resonance colors in an amorphous-Si thin layer irradiated by an ultraviolet nanosecond laser
Authors: Hwang Eui Sun , Kang Min Jin , Cheong Byoung-Ho 
Published: June 2022

The optical resonances of nanoparticles have drawn considerable attention in academia and industry; however, the formation of uniform nanoparticles has been challenging, hindering their application. Herein, we propose that reflective-type color filters can be achieved using the optical resonance effect arising from Si nanoparticles created on an amorphous Si thin film via laser irradiation. Multiple equally spaced irradiations of an amorphous-Si surface by a Gaussian laser beam created Si nanoparticles with sizes of 100–200 nm at laser fluences in the range of 150–200 mJ/cm2. Furthermore, we demonstrated that the resonance colors could be tuned to red, green, and blue by adjusting the laser fluence and scan speed. The optical properties of the nanoparticles were analyzed using dark-field microscopy, scanning electron microscopy, and transmission electron microscopy. According to the measured nanoparticle geometries and spectral data, the Si nanoparticles are spheroidal shapes embedded in the Si layer, and simulations indicate that the resonance colors originate from electric and magnetic dipoles inside the Si nanoparticles. The results could inform the fabrication of color filters in reflective display device or sensor applications through a simple laser scanning process.
Delta-like ligand 3–targeted radioimmunotherapy for neuroendocrine prostate cancer
Authors: Korsen Joshua A. , Gutierrez Julia A. , Tully Kathryn M. , Carter Lukas M. , Samuels Zachary V. , Khitrov Samantha , Poirier John T. , Rudin Charles M. , Chen Yu , Morris Michael J. , Bodei Lisa , Pillarsetty Nagavarakishore , Lewis Jason S. 
Published: June 2022

Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer with limited meaningful treatment options. NEPC lesions uniquely express delta-like ligand 3 (DLL3) on their cell surface. Taking advantage of DLL3 overexpression, we developed and evaluated lutetium-177 (
177
Lu)–labeled DLL3-targeting antibody SC16 (
177
Lu-DTPA-SC16) as a treatment for NEPC. SC16 was functionalized with DTPA-CHX-A" chelator and radiolabeled with
177
Lu to produce
177
Lu-DTPA-SC16. Specificity and selectivity of
177
Lu-DTPA-SC16 were evaluated in vitro and in vivo using NCI-H660 (NEPC, DLL3-positive) and DU145 (adenocarcinoma, DLL3-negative) cells and xenografts. Dose-dependent treatment efficacy and specificity of
177
Lu-DTPA-SC16 radionuclide therapy were evaluated in H660 and DU145 xenograft–bearing mice. Safety of the agent was assessed by monitoring hematologic parameters.
177
Lu-DTPA-SC16 showed high tumor uptake and specificity in H660 xenografts, with minimal uptake in DU145 xenografts. At all three tested doses of
177
Lu-DTPA-SC16 (4.63, 9.25, and 27.75 MBq/mouse), complete responses were observed in H660-bearing mice; 9.25 and 27.75 MBq/mouse doses were curative. Even the lowest tested dose proved curative in five (63%) of eight mice, and recurring tumors could be successfully re-treated at the same dose to achieve complete responses. In DU145 xenografts,
177
Lu-DTPA-SC16 therapy did not inhibit tumor growth. Platelets and hematocrit transiently dropped, reaching nadir at 2 to 3 wk. This was out of range only in the highest-dose cohort and quickly recovered to normal range by week 4. Weight loss was observed only in the highest-dose cohort. Therefore, our data demonstrate that
177
Lu-DTPA-SC16 is a potent and safe radioimmunotherapeutic agent for testing in humans with NEPC.
Being ambivalent by exploiting indeterminacy in the explicit import of an utterance
Authors: Piskorska Agnieszka 
Published: June 2022

AbstractIn line with recent interest in weak and often not fully determinate effects of communication permeating relevance-theoretic research, I contribute a discussion on two possible sources of speaker-intended indeterminacy within explicit import of an utterance: one residing in an intentionally underspecified location of an ad hoc concept between literal or non-literal (e.g. metaphorical or hyperbolic) interpretation, and the other lying in the higher-level explicature of an utterance, and being related to propositional attitude (e.g. pretence, reporting, dissociation) or speech-act description (e.g. complementing, reproaching). In both cases, the speaker leaves a certain amount of indeterminacy concerning the degree of her commitment to the content communicated, by not indicating where precisely the concept or the attitude is to be located on the literalness-metaphor continuum or on the continuum of various propositional attitudes/speech-act descriptions, respectively. Using a number of illustrative examples drawn from television discourse, I try to show that this kind of intended indeterminacy gives rise to communicative effects of a non-propositional kind. Additionally, the analyses presented here support the deflationary view of figurative uses of language, on which they form continua with non-figurative utterances.
Magnetic cross-talk simulation for Iranian Light Source Facility storage ring
Authors: Yousefnejad S. , Saeidi F. , Razazian M. , Ahmadi E. 
Published: June 2022

Abstract
Magnetic cross-talk due to the small free space between the
magnets of a machine may result in significant distortions of the
magnetic field integration and performance distortion of the
machine. This paper presents the preparation done at the Iranian
Light Source Facility (ILSF) on integrated magnetic components of
three storage ring (SR) magnets with minimum space between the
yokes, modeled separately in Opera-3D code and accumulatively as in
the lattice design. The results show that the integrated quadrupole
component of the BE2 dipole magnet remains nearly the same, while
the integrated dipole and sextupole components are reduced by 0.13%
and 4.69%, respectively. By the same token, the integrated
quadrupole component of the Q11 in the lattice is decreased by
0.07%, and the integrated sextupole component of the S4 sextupole
is reduced by 8.14%. The probable deviation on the higher-order
integrated multipoles together with harmonic fields along the beam
trajectory are discussed, and some studies are introduced to cut
down any deficient effects.
Source decomposition of eddy-covariance CO2 flux measurements for evaluating a high-resolution urban CO2 emissions inventory
Authors: Wu Kai , Davis Kenneth J , Miles Natasha L , Richardson Scott J , Lauvaux Thomas , Sarmiento Daniel P , Balashov Nikolay V , Keller Klaus , Turnbull Jocelyn , Gurney Kevin R , Liang Jianming , Roest Geoffrey 
Published: June 2022

Abstract
We present the comparison of source-partitioned CO2 flux measurements with a high-resolution urban CO2 emissions inventory (Hestia). Tower-based measurements of CO and 14C are used to partition net CO2 flux measurements into fossil and biogenic components. A flux footprint model is used to quantify spatial variation in flux measurements. We compare the daily cycle and spatial structure of Hestia and eddy-covariance derived fossil fuel CO2 emissions on a seasonal basis. Hestia inventory emissions exceed the eddy-covariance measured emissions by 0.36 µmol m−2 s−1 (3.2%) in the cold season and 0.62 µmol m−2 s−1 (9.1%) in the warm season. The daily cycle of fluxes in both products matches closely, with correlations in the hourly mean fluxes of 0.86 (cold season) and 0.93 (warm season). The spatially averaged fluxes also agree in each season and a persistent spatial pattern in the differences during both seasons that may suggest a bias related to residential heating emissions. In addition, in the cold season, the magnitudes of average daytime biological uptake and nighttime respiration at this flux site are approximately 15% and 27% of the mean fossil fuel CO2 emissions over the same time period, contradicting common assumptions of no significant biological CO2 exchange in northern cities during winter. This work demonstrates the effectiveness of using trace gas ratios to adapt eddy-covariance flux measurements in urban environments for disaggregating anthropogenic CO2 emissions and urban ecosystem fluxes at high spatial and temporal resolution.
The use of cotton gene pool in the selection process
Authors: Makhmadjanov S P , Tokhetova L A , Yesimbekova M A , Daurenbek N M , Kostak O A 
Published: June 2022

Abstract
Cotton growing is the most important industry that determines the strategic security of the country. Scientists of the "Agricultural and Melon Industry" LLP consider their genetic collection to be unique, since the cotton plants collected in it have the widest range of economically valuable qualities. There are groups of cotton with different types of branching, with different heights of the main stem and shape of the leaf, with different types of seed pads, with capsules of various shapes and sizes, with different resistance to pests and diseases. It is important that the collection "works" for practice. Its use in the breeding process made it possible for the first time in world practice to create and regionalize new high-yielding medium-fiber varieties of cotton with a short growing season Pakhtaaral-3031, Pakhtaaral-3044, Maktaaral-4005, BTM-4047, Atakent-2010, Bereke-07, Maktaaral-4007, Maktaaral-4011, Myrzashol-80, Maktaaral-4017, Maktaaral-5027. The use of the collection in further scientific work opens up great opportunities for creating new varieties and lines of the most important crop, which is cotton. Research on the cotton gene pool is currently being carried out in the direction of maintaining their viability. The effective use of the cotton gene pool depends on the scale and depth of assessment of its quality, with the strategic objectives of cotton growing and the level of organization and efficiency of the breeding process. The cotton varieties that occupy the area were bred on the basis of hybridization of varieties and subspecies of Y. Hirsutum L., which unites their potential for resistance to abiotic stress factors.
The nature of organic carbon and total nitrogen distribution in the fractions of leached chernozem aggregates and gray soil in Western Siberia
Authors: Eremin D I , Demin E A 
Published: June 2022

Abstract
The features of the accumulation and distribution of organic carbon and nitrogen in the aggregates of the arable layer of leached chernozem (Luvic Voronic Chernozems) and gray forest soil (Luvic Retic Greyzemic Phaeozems) were evaluated. After dry sieving in structural separates of dimensional fractions >10, 10-5, 5-2, 2-1, 1-0.25, and <0.25 mm, the content of organic carbon and total nitrogen was determined in the laboratory. It was found that chernozem and gray forest soil significantly differed from each other in organic carbon in all fractions of structural separates. Lumpy aggregates (>10 mm) and fine earth (<0.25 mm) were characterized by an average spatial variability (CV up to 21%) of organic carbon and total nitrogen content. In chernozem arable layer, the maximum content of organic carbon and total nitrogen was in size fractions from 5 to 0.25 mm, whereas in gray forest soil – from 10 to 2 mm. Maximum value of C:N in gray forest soil was 16.0 units in aggregates with dimensions less than 0.25 mm, and in chernozem – in the lumpy fraction (> 10 mm), where the ratio was 15.1 units it was revealed that the content of organic carbon in structural units depends on the soil type by 21%, and on the dimensional fraction by 37%. The total nitrogen content is determined by 20% by the soil type and 36% by the size of structural aggregates.
Ways of development of agriculture and processing industry enterprises manufacturing cooperation
Authors: Tukhtabaev J Sh , Uktamov Kh F , Tillaeva B R , Akramova R R , Goziyeva A A 
Published: June 2022

Abstract
This article describes the ways to develop production cooperation of enterprises of agriculture and processing industry. Scientific-theoretical and methodological-practical solutions to the problems of production cooperation of agricultural and industrial enterprises are covered by scientific research of CIS countries, foreign scientists and local scientists. World experience has shown that the efficiency of agricultural producers depends not only on cooperation based on the principles of internal division of labor on farms, but also on intersectoral cooperation and integration of production, storage, processing and sale of raw materials.