bluuebunny/crossref_metadata_2025_split huggingface dataset:
Papyrus production revisited: differences between ancient and modern production modes
Authors: Bausch Florian , Rosado Mario J. , Rencoret Jorge , Marques Gisela , Gutiérrez Ana , Graf Jörg , del Río José C. , Rosenau Thomas , Potthast Antje 
Published: April 2022

AbstractPapyrus, produced from the white pith of Cyperus papyrus L., has been used for millennia as the major writing support by ancient cultures, but there was no continuous papyrus production until modern times. Therefore, papyrus production had to be rediscovered. Modern Egyptian papyrus producers claim that their sheets possess ‘the same physical and chemical properties as ancient papyri’. To study if this is accurate, commercially available papyrus sheets were compared to ancient papyri and papyri produced according to Pliny’s historic description. Material characterization was performed with a focus on the potentially color-bearing lignin. Two-dimensional nuclear magnetic resonance spectroscopy, derivatization followed by reductive cleavage, and pyrolysis–gas chromatography/mass spectrometry were complemented with microscopy and tests for surface pH and sodium content. The lignin data in the native pith and commercial sheets were compared to 10 ancient samples from the Papyrus Museum Vienna. The analytical data clearly show the involvement of a strong alkaline treatment followed by chlorine bleaching for commercial papyri, as expressed by higher pH values, altered lignin structures, and chlorinated lignin compounds. The inclusion of an alkaline step in ancient papyrus manufacture is discussed but dismissed, since the alkali-treatment causes a huge decrease in lignin content, that was not found for the analysed ancient specimen. We assume that this additional treatment was introduced to obtain yellowish papyrus sheets meeting optical expectations of modern spectators. Linguistic and art historic evidence indicates that such a step would not have made sense in antiquity, since it was desired to produce white papyri.
On the Cost-Effective Temporal Allocation of Credits in Conservation Offsets when Habitat Restoration Takes Time and is Uncertain
Authors: Drechsler Martin 
Published: April 2022

AbstractTradable permits, or offsetting schemes, are increasingly used as an instrument for the conservation of biodiversity on private lands. Since the restoration of degraded land often involves uncertainties and time lags, conservation biologists have strongly recommended that credits in conservation offset schemes should be awarded only with the completion of the restoration process. Otherwise, the instrument is claimed to fail on the objective of no net loss in species habitat and biodiversity. What is ignored in these arguments, however, is that such a scheme design may incur higher economic costs than a design in which credits are already awarded at the initiation of the restoration process. In the present paper a generic agent-based ecological-economic simulation model is developed to explore different pros and cons of the two scheme designs, in particular their cost-effectiveness. The model considers spatially heterogeneous and dynamic conservation costs, risk aversion and time preferences in the landowners, as well as uncertainty in the duration and the success of the restoration process. It turns out that, especially under fast change of the conservation costs, awarding credits at the initiation of restoration can be more cost-effective than awarding them with completion of restoration.
A twenty-first century perspective on concepts of modern epidemiology in Ignaz Philipp Semmelweis’ work on puerperal sepsis
Authors: Stang Andreas , Standl Fabian , Poole Charles 
Published: April 2022

AbstractWe aimed to review Semmelweis’s complete work on puerperal sepsis mortality in maternity wards in relation to exposure to cadavers and chlorine handwashing and other factors from the perspective of modern epidemiological methods. We reviewed Semmelweis' complete work and data as published by von Györy 1905 according to current standards. We paid particular attention to Semmelweis's definition of mortality in and of itself, to concepts of modern epidemiology that were already recognizable in Semmelweis's work, and to bias sources. We did several quantitative bias analyses to address selection bias and information bias from outcome measurement error. Semmelweis addressed biases that have become known to modern epidemiology, such as confounding, selection bias and bias from outcome misclassification. Our bias analysis shows that differential loss to follow-up is an unlikely explanation for his results. Bias due to outcome misclassification would only be relevant if misclassification differed between time periods. Confounding by health status was likely but could not be quantitatively addressed. Semmelweis was aware that cause-specific mortality is a function of incidence and prognosis. He reasoned in potential outcome terms to estimate the reduced number of deaths from an intervention. He advanced a hypothesis of clinic overcrowding as a risk factor for puerperal sepsis mortality that turns out to be wrong. Semmelweis’ data provide a great pool for illustrating the logic of scientific discovery by use of the numerical method. The explanatory power of his work was strong and Semmelweis was able to refute several previous causal explanations.
Managing In-Company IT Standardization: A Design Theory
Authors: Ahlemann Frederik , Dittes Sven , Fillbrunn Tim , Rehring Kevin , Reining Stefan , Urbach Nils 
Published: April 2022

Abstract
Today’s companies rely heavily on in-company information technology standards (ICITS) to reduce costs, ensure flexibility, and facilitate the planning, implementation, and operation of IT systems. Steering and managing ICITS has proven to be challenging, revealing the need for efficient governance mechanisms. But even though prior research demonstrates the challenges of ICITS, viable advice on how to implement ICITS is scarce. In this paper, we develop an organizational design theory for the management of ICITS based on the framework of organizational control theory. We conducted a critical case study to identify basic goals, constitutive elements, and fundamental mechanisms of a working ICITS management. The resulting design goals and principles were then evaluated and further refined in the light of additional expert interviews. With our work, we wish to extend the body of theoretical knowledge on the management of ICITS and help practitioners master the various challenges occurring in this domain.
Listen to the Children: Elementary School Students' Perspectives on a Mindfulness Intervention
Authors: D’Alessandro Andrea M. , Butterfield Kaitlyn M. , Hanceroglu Lerna , Roberts Kim P. 
Published: April 2022

AbstractIn recent years, mindfulness-based practices in grade schools have been associated with students’ improved cognitive skills and general classroom behavior. In the majority of studies, however, only teacher and parent feedback are elicited, omitting a considerably significant voice – that of the students. Our study aims to fill this gap by exploring student opinions and perceptions regarding the implementation of a classroom-based mindfulness program. Elementary school students (N = 51) took part in teacher-facilitated mindfulness activities which were incorporated into their daily classroom routines. Over the course of the 8-week intervention period, students participated in focus groups about their perceptions of the program. Through qualitative content analysis, two major findings emerged from the focus group data: student opinions about the mindfulness program varied substantially and the mindfulness activities were not always liked and enjoyed. Critically, if students do not enjoy classroom-based mindfulness programs, they may be less motivated to engage in mindful activities and in turn may not experience the benefits that mindfulness has to offer. To maximize student engagement with mindfulness while addressing their concerns, the following recommendations are made: A balance between the entertaining and educational aspects of the program, flexible program delivery, and encouraging students to pursue mindful living outside of the classroom. This research is important to educational and clinical practitioners as student insight will benefit the development and modification of classroom-based mindfulness programs to ensure that students are better able to engage with and benefit from these programs.
The miR-183/96/182 cluster is upregulated in glioblastoma carrying EGFR amplification
Authors: Schneider Björn , William Doreen , Lamp Nora , Zimpfer Annette , Henker Christian , Classen Carl Friedrich , Erbersdobler Andreas 
Published: April 2022

AbstractGlioblastoma (GBM) is one of the most frequent primary brain tumors. Limited therapeutic options and high recurrency rates lead to a dismal prognosis. One frequent, putative driver mutation is the genomic amplification of the oncogenic receptor tyrosine kinase EGFR. Often accompanied by variants like EGFRvIII, heterogenous expression and ligand independent signaling render this tumor subtype even more difficult to treat, as EGFR-directed therapeutics show only weak effects at best. So EGFR-amplified GBM is considered to have an even worse prognosis, and therefore, deeper understanding of molecular mechanisms and detection of potential targets for novel therapeutic strategies is urgently needed. In this study, we looked at the level of microRNAs (miRs), small non-coding RNAs frequently deregulated in cancer, both acting as oncogenes and tumor suppressors. Comparative analysis of GBM with and without EGFR amplification should give insight into the expression profiles of miRs, which are considered both as potential targets for directed therapies or as therapeutic reagents. Comparison of miR profiles of EGFR-amplified and EGFR-normal GBM revealed an upregulation of the miR-183/96/182 cluster, which is associated with oncogenic properties in several tumor entities. One prominent target of this miR cluster is FOXO1, a pro-apoptotic factor. By observing FOXO1 downregulation in EGFR-amplified tumors, we can see a significant correlation of EGFR amplification, miR-183/96/182 cluster upregulation, and repression of FOXO1. Although no significant difference in overall survival is shown, these data may contribute to the molecular understanding of this tumor subtype and offer potential targets for miR-based therapies.
AFD-Net: Apple Foliar Disease multi classification using deep learning on plant pathology dataset
Authors: Yadav Anju , Thakur Udit , Saxena Rahul , Pal Vipin , Bhateja Vikrant , Lin Jerry Chun-Wei 
Published: April 2022

Abstract
Background
Plant diseases significantly affect the crop, so their identification is very important. Correct identification of these diseases is crucial for establishing a good disease control strategy to avoid time and financial losses. In general, machines can greatly reduce the possibility of human error. In particular, computer vision techniques developed through deep learning have paved a way to detect and diagnose these plant diseases on the leaf.

Methods
In this work, the model AFD-Net was developed to detect and identify various leaf diseases in apple trees. The dataset is from Kaggle 2020 and 2021 and was financially supported by the Cornell Initiative for Digital Agriculture. An AFD-Net was proposed for leaf disease classification in apple trees and the results of the efficiency of the model are compared with other state-of-the-art deep learning approaches.

Results
The results of the experiments in the validation dataset show that the proposed AFD-Net model achieves the highest values of 98.7% accuracy for Plant Pathology 2020 and 92.6% for Plant Pathology 2021 compared to other deep learning models in the original and extended datasets.

Discussion
The results also indicate the efficiency of the proposed model in identifying leaf diseases on apple trees for major and minor classes, i.e., for multiple classification.
Influence of Classroom-Level Factors on Implementation Fidelity During Scale-up of Evidence-Based Interventions
Authors: Combs Katie Massey , Buckley Pamela R. , Lain Marion Amanda , Drewelow Karen M. , Urano Grace , Kerns Suzanne E. U. 
Published: April 2022

AbstractAs evidence-based interventions (EBIs) become more widely disseminated, fidelity of implementation (FOI) often wanes. This study explores the association between FOI and malleable variables within classrooms that could be targeted to optimize resources without compromising FOI as school-based EBIs are disseminated across real-world settings. We utilized process evaluation data from a national dissemination project of the Botvin LifeSkills Training (LST) middle school program, a universal prevention intervention shown to reduce substance use. The sample included 1,626 teachers in 371 schools across 14 states. Hierarchical linear models examined the relationship between observational measures of implementation factors and three domains of fidelity (e.g., adherence, student responsiveness, and quality of delivery). Findings suggest that curriculum modifications, student misbehavior, and shortage of time to implement the LST middle school program were factors most associated with lower FOI. Class size, access to program materials, and whether LST was delivered in a traditional classroom setting that is well-suited for instruction (versus in a less structured environment such as the school cafeteria) are less predictive. In scale-up of classroom-based universal interventions targeting behavioral health outcomes, our findings indicate that carefully vetting modifications, supporting classroom management strategies, and ensuring sufficient class time for implementation of highly interactive EBIs such as LST are important considerations. Since changes to EBIs are inevitable, efforts are needed to guide facilitators in making adjustments that improve program fit without compromising the essential intervention activities deemed necessary to produce desired outcomes.
Criteria for developing, assessing and selecting candidate EQ-5D bolt-ons
Authors: Mulhern Brendan J. , Sampson Chris , Haywood Phil , Addo Rebecca , Page Katie , Mott David , Shah Koonal , Janssen Mathieu F. , Herdman Mike 
Published: April 2022

Abstract
Purpose
‘Bolt-on’ dimensions are additional items added to multi-attribute utility instruments (MAUIs) such as EQ-5D that measure constructs not included in the core descriptive system. The use of bolt-ons has been proposed to improve the content validity and responsiveness of the descriptive system in certain settings and health conditions. EQ-5D bolt-ons serve a particular purpose and thus satisfy a certain set of criteria. The aim of this paper is to propose a set of criteria to guide the development, assessment and selection of candidate bolt-on descriptors.

Methods
Criteria were developed using an iterative approach. First, existing criteria were identified from the literature including those used to guide the development of MAUIs, the COSMIN checklist and reviews of existing bolt-ons. Second, processes used to develop bolt-ons based on qualitative and quantitative approaches were considered. The information from these two stages was formalised into draft development and selection criteria. These were reviewed by the project team and iteratively refined.

Results
Overall, 23 criteria for the development, assessment and selection of candidate bolt-ons were formulated. Development criteria focused on issues relating to i) structure, ii) language, and iii) consistency with the existing EQ-5D dimension structure. Assessment and selection criteria focused on face and content validity and classical psychometric indicators.

Conclusion
The criteria generated can be used to guide the development of bolt-ons across different health areas. They can also be used to assess existing bolt-ons, and inform their inclusion in studies and patient groups where the EQ-5D may lack content validity.
Chinese students’ access, use and perceptions of ICTs in learning mathematics: findings from an investigation of Shanghai secondary schools
Authors: Fan Lianghuo , Luo Jietong , Xie Sicheng , Zhu Fangchun , Li Shuhui 
Published: April 2022

AbstractDue to rapid social and economic development in China over the last three decades, information and communication technologies (ICTs) have become increasingly available in Chinese classrooms and families. However, there is a lack of research regarding Chinese students’ use of ICTs in mathematics learning. In this study, we examined how Chinese students access, use, and perceive ICTs in learning mathematics. To this end, a conceptual framework for ICTs and the role of ICTs in students’ learning of mathematics was established. Using a mixed-methods approach, we collected data from 223 students in four randomly selected secondary schools in Shanghai through a questionnaire survey, followed by classroom observations and interviews with students and teachers. The results revealed that various ICTs are widely accessible in Shanghai classrooms and students overall have a positive view about the role of ICTs in their mathematics learning, especially in problem solving and in learning geometry. When learning mathematics at home, students used handheld technological devices more frequently than non-portable devices. Furthermore, there were significant differences between different students in terms of school performance levels, grade levels, and genders in their use of ICTs in learning mathematics. In particular, students from high-performing schools had more access to various ICTs but used them less frequently than their peers from ordinary schools. Suggestions and implications of the findings are discussed at the end of the paper.
Characterization of Bacterial and Archaeal Communities by DGGE and Next Generation Sequencing (NGS) of Nitrification Bioreactors Using Two Different Intermediate Landfill Leachates as Ammonium Substrate
Authors: González-Cortés J. J. , Valle A. , Ramírez M. , Cantero D. 
Published: April 2022

AbstractNitrification–denitrification is an environmentally friendly and cost-effective way to treat landfill leachates. Special attention has been given to the nitrification step, usually the limiting one due to its special sensitivity to environmental factors. Here, the effect of the acclimatization of the nitrifying biomass to two different intermediate landfill leachates with different salt concentrations, COD and BOD5 has been studied. Despite the complete nitrification being successfully performed, the specific nitritation rates were reduced after the biomass adaptation to both landfill leachates caused by the presence of heavy metals and the high salt concentration. NGS analysis of the biomass samples revealed that Proteobacteria (48.5%), Actinobacteriota (14.4%) and Chloroflexi (9.5%) were the dominant phyla in the non-adapted biomass. The leachate feeding led to a decrease in OTU diversity and favored the growth of the phyla Bacteroidetes (27.2%), Euryarchaeota (26.6%) and Proteobacteria (20.0%) accounting for more than 70% of relative abundance. Several OTUs capable of performing the nitritation belong to the Xanthobacteraceae and the Xanthomonadaceae families, the Saccharimonadales order, and the genus Nitrosomonas, Nitrosospira and Paracoccus. In the nitratation process, the Xanthobacteraceae family and Lautropia and Nitrolancea genera were found.
Graphical Abstract
A Case-Crossover Study of the Impact of the Modifying Industrial Operations Protocol on the Frequency of Industrial Forestry-Caused Wildland Fires in Ontario, Canada
Authors: Granville Kevin , Woolford Douglas G. , Dean C. B. , McFayden Colin B. 
Published: April 2022

AbstractWildland fire prevention and mitigation is of mutual interest to both government and the forest industry. In 1989, the Ontario Ministry of Natural Resources and Forestry introduced the Woods Modification Guidelines that provided rules on how forestry operations should be modified based on local fire danger conditions. Those guidelines were replaced by the Modifying Industrial Operations Protocol (MIOP) in 2008. One objective of MIOP is to allow forestry operations to be done safely for as long as possible as the fire danger increases. We investigate the impacts of these sets of regulations on the frequency of industrial forestry-caused (IDF) wildland fires in the province of Ontario, Canada. Data from 1976 to 2019 are analyzed. A case-crossover study finds no evidence to suggest that MIOP’s greater flexibility in operating hours has increased the probability of IDF fire occurrences. This result indicates that MIOP’s regulations have had the desired effect of allowing longer working hours on days with heightened fire risk without adding to the seasonal wildland fire load.
Stabilization of a nonlinear Euler–Bernoulli beam
Authors: Benterki Djamila , Tatar Nasser-Eddine 
Published: April 2022

AbstractIn this work, we study the vibration control of a flexible mechanical system. The dynamic of the problem is modeled as a viscoelastic nonlinear Euler–Bernoulli beam. To suppress the undesirable transversal vibrations of the beam, we adopt a control at the right boundary of the beam. This control law is simple to implement. We prove uniform stability of the system using a viscoelastic material, the multiplier method and some ideas introduced in [20]. It is shown that a large range of rates of decay of the energy can be achieved through a determined class of kernels. Unlike most of the existing classes in the market, ours are not necessarily strictly decreasing.
Frictional shear stress of ZnO nanowires on natural and pyrolytic graphite substrates
Authors: Hou Lizhen , Hou Maofen , Yibibulla Tursunay , Mead James Lee , Fatikow Sergej , Wang Shiliang , Huang Han 
Published: April 2022

AbstractThe friction behaviour of ZnO nanowires on natural graphite (NG) and highly oriented pyrolytic graphite (HOPG) substrates was tested in ambient conditions by use of optical microscopy based nanomanipulation. Nanowires on the step-free and waviness-free NG substrate exhibit a diameter-independent nominal frictional shear stress of 0.48 MPa, and this provides a benchmark for studying how the surface topography of graphite influences nanowire friction. Nanowires on the HOPG substrate present a significant diameter-dependent frictional shear stress, increasing from 0.25 to 2.78 MPa with the decrease of nanowire diameter from 485 to 142 nm. The waviness of HOPG has a limited effect on the nanowire friction, as a nanowire can fully conform to the substrate. The surface steps on the HOPG can significantly enhance the nanowire friction and lead to a much higher frictional shear stress than that on NG due to mechanical blocking and the presence of a Schwoebel barrier at step edges. The surface steps, however, can also generate small wedge-shaped gaps between a nanowire and substrate, and thus reduce the nanowire friction. With the decrease in nanowire diameter, the capacity for the nanowire to better conform to the substrate reduces the length of the wedge-shaped gaps, leading to the observed increase in nanowire friction. The results have improved our understanding of the unique friction behaviour of nanowires. Such an improved understanding is expected to benefit the design and operation of nanowire-friction-based devices, including bio-inspired fibrillar adhesives, soft grippers, rotary nanomotors, and triboelectric nanogenerators.