bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kieferorthopädie als Fachdisziplin im Zentrum für
Seltene Erkrankungen
Authors: Kruse Teresa , Braumann Bert 
Published: September 2022

ZusammenfassungIn diesem Artikel wird beispielhaft die Betreuung von Patientinnen und Patienten
mit Lippen-Kiefer-Gaumen-Spalten und Robin Sequenz von der pränatalen
Diagnostik bis zum Wachstumsabschluss beschrieben. Das
kieferorthopädische Behandlungsmanagement bei Betroffenen mit oro- und
kraniofazialen Fehlbildungen ist komplex, zeitintensiv und erfordert eine
interdisziplinäre Koordination. Vernetzte Zentrumsstrukturen bieten eine
bestmögliche interdisziplinäre Expertise bei diesen seltenen
Erkrankungen. Ziel und Aufbau dieser spezialisierten Zentren sollen hier
erläutert werden. Unter anderem sollten sie niederschwellig als
Ansprechpartner zur Verfügung stehen und niedergelassene
Kieferorthopädinnen und Kieferorthopäden in Therapieplanung,
Timing und Trouble-Shooting unterstützen. Das Grundverständnis
der häufigsten oro- und kraniofazialen Anomalien und die Kenntnis
über frühe Behandlungsschritte wie der Versorgung mit einer
Gaumenplatte oder Spornplatte sind für kieferorthopädisch
Behandelnde wichtig. Denn nur so kann eine sichere, effektive Therapie und eine
stabile ästhetische und funktionelle Rehabilitation
gewährleistet werden. Funktionelle Beeinträchtigungen sowie
skelettale und dentale Anomalien erfordern bei dieser Patientengruppe eine
vorausschauende kieferorthopädische Planung. Eventuell notwendige
chirurgische Eingriffe müssen im Ablauf mit bedacht und
Therapieentscheidungen immer mit dem Ziel getroffen werden, die Behandlung
möglichst effektiv zu gestalten.
Wenn der Weg das Ziel ist
Authors: Wuzel Elena , Dienst Sebastian , Maucher Helene 
Published: September 2022

ZusammenfassungSeit vielen Jahren wird hierzulande darüber diskutiert, ob das amerikanische Magnet®-Konzept auch ins deutsche Gesundheitswesen übertragen werden kann. Unsere Autoren sind sich dessen sicher und auf einem guten Weg Richtung Zertifizierung.
Development and Evaluation of Topical Ethosomal Gel for Fungal Infections
Authors: Gupta Preeti , Hafeez Abdul , Kushwaha Poonam 
Published: September 2022

AbstractBackground Fungal infections are one of the most common dermatological issues worldwide. Candida species-caused fungal infections are frequent on the cutaneous surface. Eberconazole (EBZ) has the strongest antifungal action against Candida spp., the major source of fungal infections.Method In the present study, the cold method followed by probe sonication was used to create EBZ-loaded ethosomal dispersion. The solubility of ethosomes in different lipids and surfactants was used to choose these components. Under magnetic stirring, the dispersion was absorbed into a carbopol 934 gel. In vitro antifungal activity was performed using the Agar well diffusion method, and their topical effectiveness against pathogenic Candida albicans was compared to that of a marketed formulation containing EBZ.Results Eberconazol incorporated into gel displayed sustained release in an in vitro release assay. Based on the zone of inhibition diameters, EBZ formulation was determined to be efficient against C. albicans when compared to the commercialized cream and plain gel.Conclusion Based on these findings, the current study found that EBZ possesses significant antifungal efficacy against C. albicans.
TARS2 Variants Cause Combination Oxidative Phosphorylation Deficiency-21: A Case Report and Literature Review
Authors: Gao Xin , Xin Guoyan , Tu Ya , Liang Xiaoping , Yang Huimin , Meng Hong , Wang Yumin 
Published: September 2022

Abstract
Objective The aim of the study is to explore the clinical and genetic characteristics of the combined oxidative phosphorylation defect type 21 (COXPD21) caused by the TARS2 compound heterozygous pathogenic variants, and to improve clinicians' awareness of the disease.
Methods The proband was a girl of first birth, with repeated refractory hypokalemia, hearing impairment, developmental delay, intellectual disability, developmental retardation after infection, high limb muscle tension, and increased serum lactate as the clinical phenotype. The clinical performance, diagnosis, treatment process, and gene characteristics of COXPD21 caused by TARS2 of the case were analyzed, reviewed, and compared with the literature from the CNKI, Wanfang Data, and biomedical literature database (PubMed) until November 2021.
Results The child was diagnosed with COXPD21 after two heterozygous variants in the TARS2 gene were found via whole exome sequencing. One of the variants was c.1679(exon14) A > C (p.Asp560Ala) missense, derived from the mother, and the other was c.1036(exon10)C > T (p.Arg346Cys) missense, derived from the father. The literature was searched and reviewed with the keywords “mitochondrial encephalomyopathy,” “TARS2,” and “combination oxidative phosphorylation deficiency type 21.” A total of four complete domestic and foreign cases were collected from the literature search.
Conclusion COXPD21 onset by a complex heterozygous variant of TARS2 causes refractory hypokalemia, which is rarely reported in China and abroad.
3LGM2IHE: Requirements for Data-Protection-Compliant Research Infrastructures—A Systematic Comparison of Theory and Practice-Oriented Implementation
Authors: Gött Robert , Stäubert Sebastian , Strübing Alexander , Winter Alfred , Merzweiler Angela , Bergh Björn , Kaulke Knut , Bahls Thomas , Hoffmann Wolfgang , Bialke Martin 
Published: September 2022

Abstract
Objectives The TMF (Technology, Methods, and Infrastructure for Networked Medical Research) Data Protection Guide (TMF-DP) makes path-breaking recommendations on the subject of data protection in research projects. It includes comprehensive requirements for applications such as patient lists, pseudonymization services, and consent management services. Nevertheless, it lacks a structured, categorized list of requirements for simplified application in research projects and systematic evaluation. The 3LGM2IHE (“Three-layer Graphbased meta model – Integrating the Healthcare Enterprise [IHE] ” ) project is funded by the German Research Foundation (DFG). 3LGM2IHE aims to define modeling paradigms and implement modeling tools for planning health care information systems. In addition, one of the goals is to create and publish 3LGM2 information system architecture design patterns (short “design patterns”) for the community as design models in terms of a framework. A structured list of data protection-related requirements based on the TMF-DP is a precondition to integrate functions (3LGM2 Domain Layer) and building blocks (3LGM2 Logical Tool Layer) in 3LGM2 design patterns.
Methods In order to structure the continuous text of the TMF-DP, requirement types were defined in a first step. In a second step, dependencies and delineations of the definitions were identified. In a third step, the requirements from the TMF-DP were systematically extracted. Based on the identified lists of requirements, a fourth step included the comparison of the identified requirements with exemplary open source tools as provided by the “Independent Trusted Third Party of the University Medicine Greifswald” (TTP tools).
Results As a result, four lists of requirements were created, which contain requirements for the “patient list”, the “pseudonymization service”, and the “consent management”, as well as cross-component requirements from the TMF-DP chapter 6 in a structured form. Further to requirements (1), possible variants (2) of implementations (to fulfill a single requirement) and recommendations (3) were identified. A comparison of the requirements lists with the functional scopes of the open source tools E-PIX (record linkage), gPAS (pseudonym management), and gICS (consent management) has shown that these fulfill more than 80% of the requirements.
Conclusions A structured set of data protection-related requirements facilitates a systematic evaluation of implementations with respect to the fulfillment of the TMF-DP guidelines. These re-usable lists provide a decision aid for the selection of suitable tools for new research projects. As a result, these lists form the basis for the development of data protection-related 3LGM2 design patterns as part of the 3LGM2IHE project.
Isolated Intradural Prepontine Chordoma Presenting with Imaging Features of Epidermoid Cyst
Authors: Alijani Babak , Namin Ahmad Kheiri 
Published: September 2022

AbstractChordoma is an erratic aggressive tumor of the brain that typically involves the clivus. The majority of the clivus chordomas reside in the extradural space. Here, we report a unique case of chordoma arising from the prepontine intradural space without bony involvement and presenting with radiological features typical of an epidermoid cyst on magnetic resonance imaging.
Radiofrequency Thermocoagulation of the Gasserian Ganglion for Trigeminal Neuralgia using a Stereotactic Approach due to a Pterygoalar Bar
Authors: Monteiro Kalínio de Kássio O. , Moura Virgílio Vilá , Santos Renato Carvalho , Anchieta Ronan Arnon , Strapasson Atahualpa Cauê Paim , Ramos Jony Soares , Monteiro Cláudia Sibele 
Published: September 2022

AbstractThe treatment of trigeminal neuralgia (TN) consists of pharmacotherapy and neurosurgical procedure, such as percutaneous radiofrequency rhizotomy. Here, we present the case of a patient with TN refractory to clinical treatment who presented an anatomical variation in the oval foramen, which required stereotactic-guided surgery to access the Gasser ganglion.This is a 63-year-old male patient who presented with TN refractory to drug treatment. He used carbamazepine and nortriptyline, with no satisfactory response. The percutaneous approach to radiofrequency thermocoagulation was indicated, in view of the comorbidities presented and the patient's age. Due to the presence of a rare anatomical variation, stereotactic-guided surgery was used to cannulate the foramen ovale and, thus, successfully perform the neurosurgical procedure with an excellent clinical response. The use of stereotaxy to guide cannulation of the foramen ovale due to anatomical variation was essential for the success of the procedure. The knowledge of the existence of this anatomical variation, and the mastery of the stereotactic technique enabled the adequate management in the face of the unusual situation.
Risk Factors for Malfunction of Ventriculoperitoneal Shunts Performed by Medical Residents in Children: An Exploratory Study
Authors: Oliveira Italo Cardoso Teixeira de , Silva Douglas Inomata Cardoso da , Matilde Jamille Duran , Botta Fábio Pires , Hamamoto Juliana Fattori , Avila Marla Andréia Garcia de , Rugolo Lígia Maria Suppo de Souza , Zanini Marco Antônio , Filho Pedro Tadao Hamamoto 
Published: September 2022

Abstract
Introduction Ventriculoperitoneal shunts (VPSs) are common neurosurgical procedures, and in educational centers, they are often performed by residents. However, shunts have high rates of malfunction due to obstruction and infection, especially in pediatric patients. Monitoring the outcomes of shunts performed by trainee neurosurgeons is important to incorporate optimal practices and avoid complications.
Methods In the present study, we analyzed the malfunction rates of VPSs performed in children by residents as well as the risk factors for shunt malfunction.
Results The study included 37 patients aged between 0 and 1.93 years old at the time of surgery. Congenital hydrocephalus was observed in 70.3% of the patients, while 29.7% showed acquired hydrocephalus. The malfunction rate was 54.1%, and the median time to dysfunction was 28 days. Infections occurred in 16.2% of the cases. Cerebrospinal fluid leukocyte number and glucose content sampled at the time of shunt insertion were significantly different between the groups (p = 0.013 and p = 0.007, respectively), but did not have a predictive value for shunt malfunction. In a multivariate analysis, the etiology of hydrocephalus (acquired) and the academic semester (1st) in which the surgery was performed were independently associated with lower shunt survival (p = 0.009 and p = 0.026, respectively).
Conclusion Ventriculoperitoneal shunts performed in children by medical residents were at a higher risk of malfunction depending on the etiology of hydrocephalus and the academic semester in which the surgery was performed.
Predictors of Adherence to Stroke Prevention in the BALKAN-AF Study: A Machine-Learning Approach
Authors: Kozieł-Siołkowska Monika , Siołkowski Sebastian , Mihajlovic Miroslav , Lip Gregory Y.H. , Potpara Tatjana S. ,   on behalf of the BALKAN-AF Investigators
Published: September 2022

Abstract
Background Compared with usual care, guideline-adherent stroke prevention strategy, based on the ABC (Atrial fibrillation Better Care) pathway, is associated with better outcomes. Given that stroke prevention is central to atrial fibrillation (AF) management, improved efforts to determining predictors of adherence with ‘A’ (avoid stroke) component of the ABC pathway are needed.
Purpose We tested the hypothesis that more sophisticated methodology using machine learning (ML) algorithms could do this.
Methods In this post-hoc analysis of the BALKAN-AF dataset, ML algorithms and logistic regression were tested. The feature selection process identified a subset of variables that were most relevant for creating the model. Adherence with the ‘A’ criterion of the ABC pathway was defined as the use of oral anticoagulants (OAC) in patients with AF with a CHA2DS2-VASc score of 0 (male) or 1 (female).
Results Among 2,712 enrolled patients, complete data on ‘A’-adherent management were available in 2,671 individuals (mean age 66.0 ± 12.8; 44.5% female). Based on ML algorithms, independent predictors of ‘A-criterion adherent management’ were paroxysmal AF, center in capital city, and first-diagnosed AF. Hypertrophic cardiomyopathy, chronic kidney disease with chronic dialysis, and sleep apnea were independently associated with a lower likelihood of ‘A’-criterion adherent management.ML evaluated predictors of adherence with the ‘A’ criterion of the ABC pathway derived an area under the receiver-operator curve of 0.710 (95%CI 0.67–0.75) for random forest with fine tuning.
Conclusions Machine learning identified paroxysmal AF, treatment center in the capital city, and first-diagnosed AF as predictors of adherence to the A pathway; and hypertrophic cardiomyopathy, chronic kidney disease with chronic dialysis, and sleep apnea as predictors of non adherence.
Acute Massive and Submassive Pulmonary Embolism: Historical Considerations/Surgical Techniques of Pulmonary Embolectomy/Novel Applications in Donor Lungs with Pulmonary Emboli
Authors: Russell Cody , Keshavamurthy Suresh 
Published: September 2022

AbstractPulmonary embolectomy has a chequered history but the quest to surgically treat a patient diagnosed with pulmonary embolism effectively spurred the development of cardiopulmonary bypass and a new dawn for cardiac surgery. The advent of cardiopulmonary bypass, extracorporeal membrane oxygenation, and computed tomography pulmonary angiogram has allowed rapid diagnosis and made surgical pulmonary embolectomy a relatively safe procedure that should be considered when indicated. Pulmonary emboli in donor lungs, often get rejected for transplantation. Ex vivo lung perfusion is among newly available technology with the ability to not only recondition marginal lungs but also treat donor lung pulmonary embolisms, effectively increasing the donor pool.
Trends in Cornea Fellowship Applications and Applicant Characteristics: A San Francisco Match Analysis
Authors: Tsou Brittany C. , Aguwa Ugochi T. , Arsiwala Lubaina T. , Burton Eleanor , Mishra Kapil , Zafar Sidra , Woreta Fasika 
Published: September 2022

Abstract
Purpose We investigate trends in cornea fellowship positions filled over time and applicant characteristics associated with matching into cornea fellowship.
Methods Characteristics of cornea fellowship applicants were assessed using deidentified 2010 to 2017 San Francisco (SF) Match data. Publicly available SF Match cornea fellowship data including the number of participating programs, number of positions offered, number of positions filled, percentage of positions filled, and number of vacancies from 2014 to 2019 were also analyzed as data from 2010 to 2013 were unavailable.
Results From 2014 to 2019, the number of cornea fellowship programs increased by 11.3% (mean 2.3% per year, p = 0.006) and the number of positions offered increased by 7.7% (mean 1.4% per year, p = 0.065). Of 1,390 applicants from 2010 to 2017, 589 (42.4%) matched into cornea. After controlling for potential covariates, graduation from a U.S residency program (odds ratio [OR]: 6.15, 95% confidence interval [CI]: 4.05–9.35, p < 0.001) and a greater number of interviews completed (OR: 1.35, 95% CI: 1.29–1.42, p < 0.001) were associated with increased odds of cornea fellowship match. A greater number of applied programs (OR: 0.97, 95% CI: 0.95–0.98, p < 0.001) was associated with decreased odds of matching into cornea fellowship. The proportion of applicants matching into cornea fellowship increased until 30 applications.
Conclusions The number of cornea fellowship programs and positions increased from 2014 to 2019. Graduation from a U.S residency program and a greater number of interviews completed were associated with an increased likelihood of cornea fellowship match. Unlike applying to any ophthalmology subspecialty fellowship, applying to greater than 30 cornea fellowship programs was associated with decreased odds of matching.
Postoperative Complications and Stoma Rates After Laparoscopic Resection of Deep Infiltrating Endometriosis with Bowel Involvement
Authors: Parra Rogério Serafim , Valério Fernando Passador , Zanardi José Vitor Cabral , Feitosa Marley Ribeiro , Camargo Hugo Parra , Féres Omar 
Published: September 2022

Abstract
Objective The purpose was to assess the rates of postoperative complications and the need of temporary stoma of laparoscopic surgical treatment for bowel endometriosis in a referral center.
Methods The surgical indication, type of operation, operative time, length of hospital stay, need for a temporary stoma, rate of conversion to open surgery, postoperative complications were evaluated.
Results One-hundred and fifty patients were included. The average duration of surgery was significantly longer for segmental resection (151 minutes) than for disc excision (111.5 minutes, p < 0.001) and shaving (96.8 minutes, p < 0.001). Patients with segmental resection had longer postoperative lengths of hospital stay (1.87 days) compared with patients with disc excision (1.43 days, p < 0.001) and shaving (1.03 days, p < 0.001). A temporary stoma was performed in 2.7% of patients. Grade II and III postoperative complications occurred in 6.7% and 4.7% patients, respectively.
Conclusion Laparoscopic intestinal resection has an acceptable postoperative complication rate and a low need for a temporary stoma.
Identifying Trends and Quantifying Growth for Technological Innovation in Knee Arthroplasty: An Analysis of a Patent Database (1990 to 2020)
Authors: Rullán Pedro J. , Grits Daniel , Potluri Ajay , Emara Ahmed K. , Klika Alison K. , Mont Michael A. , Piuzzi Nicolas S. 
Published: September 2022

AbstractTechnological innovation is the key for surgical progress in knee arthroplasty and improvement in patient outcomes. Exploring patented technologies can help elucidate trends and growth for numerous innovative technologies. However, patent databases, which contain millions of patents, remain underused in arthroplasty research. Therefore, the present study aimed to: (1) quantify patent activity; (2) group patents related to similar technologies into well-defined clusters; and (3) compare growth between technologies in the field of knee arthroplasty over a 30-year period. An open-source international patent database was queried from January 1990 to January 2020 for all patents related to knee arthroplasty A search strategy identified 70,154 patents, of which 24,425 were unique and included analysis. Patents were grouped into 14 independent technology clusters using Cooperative Patent Classification (CPC) codes. Patent activity was normalized via a validated formula adjusting for exponential growth. Compound annual growth rates (CAGR) were calculated (5-year, 10-year, and 30-year CAGR) and compared for each cluster. Overall yearly patent activity increased by 2,023%, from 104 patents in 1990 to 2,208 patents in 2020. The largest technology clusters were “drugs” (n = 5,347; 23.8%), “components” (n = 4,343; 19.0%), “instruments” (n = 3,130; 13.7%), and “materials” (n = 2,378; 10.4%). The fastest growing technologies with their 5-year CAGR were: “user interfaces for surgical systems” (58.1%); “robotics” (28.6%); “modularity” (21.1%); “navigation” (15.7%); and “computer modeling” (12.5%). Since 1990, overall patent growth rate has been greatest for “computer modeling” (8.4%), “robotics” (8.0%), “navigation” (7.9%), and “patient-specific instrumentation” (6.4%). Most patents in knee arthroplasty for the last 30 years have focused on drugs, components, instruments, and materials. Recent exponential growth was mainly observed for user interfaces for surgical systems, robotics, modularity, navigation, and computer-assisted technologies. Innovation theory would suggest that these rapidly growing technologies are experiencing high innovation output, increased resource investments, growing adoption by providers, and significant clinical impact. Periodic monitoring of technological innovation via patent databases can be useful to establish trends and future directions in the field of knee arthroplasty.
Evaluation of Surgical Gown Cuff Contamination During Orthopaedic Surgery in a Veterinary Teaching Hospital
Authors: Brand Kenneth J. , Malek Sarah , Ruple Audrey , Hendrix G. Kenitra 
Published: September 2022

Abstract
Objective The objective of this study was to determine the frequency of positive cultures of the surgical gown cuffs among scrubbed personnel prior to and immediately after orthopaedic surgical procedures performed on client-owned dogs.
Study Design In this cross-sectional study, the left and right surgical gown cuffs of three scrubbed persons in 10 orthopaedic surgical procedures were individually sampled using a sterile wipe prior to and immediately after surgery in order to determine the frequency of and risk factors associated with positive bacterial cultures.
Results Fifty of 120 (41.6%) cultures were positive with an even distribution before and after surgery. The three most common genera were Staphylococcus, Corynebacterium and Streptococcus. Using multivariable logistic regression models, humidity in the operating room (odds ratio: 1.04, 95% confidence interval: 1.00–1.08; p = 0.038) and the number of individuals scrubbed into surgery (odds ratio: 0.59, 95% confidence interval: 0.39–0.91; p = 0.016) had a significant effect on the likelihood of positive culture after surgery. Of the nine patients available for follow-up, one dog developed osteomyelitis.
Conclusions Maintaining the humidity in the operating room to the lowest comfortable level may reduce contamination of the surgical gown cuffs. Confirmation of bacterial contamination of surgical gown cuffs warrants adherence to operative guidelines to minimize the risk of surgical gown cuffs' contact with sterile attire, equipment and the surgical field during surgical procedures.