bluuebunny/crossref_metadata_2025_split huggingface dataset:
Viscosity‐Independent Velocity of Neutrophils Rolling on P‐Selectin In Vitro or In Vivo
Authors: SMITH MICHAEL L. , SMITH McRAE J. , LAWRENCE MICHAEL B. , LEY KLAUS 
Published: September 2022

ABSTRACTObjective: To determine whether selectin‐mediated leukocyte‐rolling velocity in inflamed venules in vivo is determined by wall shear rate (WSR) or by wall shear stress (WSS).Methods: WSS was manipulated independently of WSR by altering the viscosity of blood plasma in mice with an isovolemic exchange of blood for low‐ or high‐viscosity dextran solutions. Rolling of neutrophils or beads coated with P‐selectin glycoprotein ligand‐1 (PSGL‐1) was reconstituted on P‐selectin immobilized on the wall of a parallel plate flow chamber at two different viscosities of the perfusion medium.Results: Leukocytes in vivo showed no increase in rolling velocity when shear stress was doubled by doubling viscosity. Neutrophils in the parallel‐plate flow chamber in vitro showed the same dependence on WSR as leukocytes in vivo, but bead‐rolling velocities correlated best with WSS. Rolling leukocytes, but not beads, deformed significantly in shear flow, and deformation correlated better with WSS.Conclusion: These data suggest leukocyte deformation during rolling offsets increased bond breakage at higher shear stress. The stable rolling velocity allows sufficient surveillance of the endothelial surface, even in venules with high WSS.
Distributed non‐ideal leader estimation and formation control for multiple non‐holonomic mobile robots
Authors: Lu Peifen , Ren Zhigang , Wu Zongze , Li Zhipeng , Zhou Shichao 
Published: September 2022

AbstractThis paper studies a distributed formation problem for non‐holonomic mobile robots. Consideration of the leader dynamics of the robots as non‐ideal, that is, subject to disturbances/unmodelled variables, is the distinguishing feature of this work. The issue is resolved by a distributed combined disturbance‐and‐leader estimator, allowing for the distributed reconstruction of the leader's signals. The estimator needs to detect the leader's information and disturbance. In order to reject such disturbance and achieve the formation asymptotically, the control law incorporates the smooth estimator's estimate of the leader disturbance. Furthermore, the stability of the total distributed formation control algorithm is also examined using the Lyapunov technique. Finally, to show the viability of the proposed theoretical results, simulations and actual experiments are carried out.
Predictive deadbeat average model control for phase‐shifted full‐bridge DC/DC converter
Authors: Zhu Yingda , Xiao Muxuan , Ouyang Honglin , Liu Qisheng , Wang Liang 
Published: September 2022

AbstractDigital current control method is the mainstream method for high‐power DC/DC converters. However, digital controllers require additional filters for noise suppression to ensure their proper operation in the complicated electromagnetic environment. The filtering processes coupled with the inherent time delays of digital systems significantly degrade dynamic performance. Thus, steady‐state performance is improved at cost of dynamic performance in conventional current control. To solve the problems, this paper establishes a deadbeat average control model based on application of the oversampling technique for phase‐shifted full‐bridge (PS‐FB) DC/DC converter and proposes a predictive deadbeat average model control method by incorporating predictive control into the proposed control model. Simulation and experimental results verify the effectiveness of the proposed control method in mitigating the contradiction between steady‐state performance and dynamic performance in the digital system.
Reduced 5-Year Risk for Revision of the Oxford UKA Using New Instrumentation versus Conventional Instrumentation: A Registry Study of 12,867 UKAs
Authors: van Langeveld Stephan J. , Janssen Stein J. , Koenraadt Koen L. M. , Elmans Leon H. G. J. , van Steenbergen Liza N. , van Geenen Rutger C. I. 
Published: September 2022

AbstractMicroplasty instrumentation was introduced for a more consistent surgical implantation technique, especially component alignment and tibial resection level, of the Oxford medial unicompartmental knee arthroplasty (UKA) and thereby aims to improve UKA survival. This study aimed to assess the 5-year risk for revision and reasons for revision of the Oxford medial UKA using the new instrumentation (Microplasty) with its predecessor, that is, conventional instrumentation (Phase 3). Data of all medial UKAs from the Dutch Arthroplasty Register (Landelijke Registratie Orthopedische Implantaten) between 2007 and 2019 were collected. Type of instrumentation was divided into new (Microplasty) and conventional instrumentation. Kaplan–Meier analysis was performed to calculate 5-year cumulative revision percentage with any reason for revision as end point. A multivariable Cox regression with outcome revision of UKA adjusted for age, gender, American Society of Anesthesiologists score, surgical history, and type of fixation was performed. Additionally, reasons for revision at 3-year were assessed and tested through Fisher's exact tests. A total of 12,867 Oxford medial UKAs, 8,170 using new and 4,697 using conventional instrumentation, were included. The 5-year revision percentage was 9.2% (95% confidence interval [CI]: 8.4–10.1%) for UKAs using the conventional and 6.1% (95% CI: 5.4–6.7%) for new instrumentation. The adjusted hazard ratio for revision at 5-year follow-up was 0.74 (95% CI: 0.63–0.87) in favor of UKAs using the new instrumentation. Malalignment was more frequently registered as reason for revision in UKAs using the conventional compared with the new instrumentation (16% versus 7.5%; p = 0.001). Our results show a reduced 5-year risk for revision of the medial Oxford UKAs using the new compared with the conventional instrumentation. This might be the result of a lower revision rate for malalignment in UKAs using the new instrumentation.
Mid-Term Clinical and Radiological Outcomes of Lateral Meniscal Allograft Transplantation with Suture-Only Fixation Plus Capsulodesis
Authors: Morales-Avalos Rodolfo , Masferrer-Pino Ángel , Padilla-Medina José Ramón , Amestoy-Ramos Jorge , Ibáñez Maximiliano , Perelli Simone , Ariztegui-Andrade Cristina , Espregueira-Mendes João , Monllau Joan Carles 
Published: September 2022

AbstractMeniscal allograft transplantation (MAT) is an effective reconstructive procedure for treating a symptomatic postmeniscectomy syndrome. It consists of replacing the lost meniscal tissue aiming to improve the clinical outcomes and prevent progressive deterioration of the joint. The aim of this study was to evaluate meniscal graft survivorship and report on the radiographic (in terms of graft extrusion and joint space width and alignment) and the functional results through a midterm follow-up of lateral MAT performed with a soft tissue fixation technique after capsulodesis. In total, 23 patients who underwent lateral MAT as a single procedure were included. The Knee injury and Osteoarthritis Outcome Score, Lysholm, Tegner, and visual analog scale scales were used for patient assessment. Magnetic resonance imaging and a complete radiographic protocol were conducted to determine the degree of meniscal extrusion and the changes in the degree of osteoarthritis and coronal alignment. Assessments were performed after 2 and 7 years of follow-up. A significant improvement in all the scores, relative to preoperative values, was found after 7 years of follow-up. This improvement remained consistent throughout the first and second follow-up periods. A mean absolute extrusion of 2.2 mm ± 1.6 and an extrusion percentage of 28.0% ± 11.43 were found, with no significant differences throughout the follow-up periods. There was no statistically significant difference in terms of the frontal mechanical axis and joint space narrowing between the preoperative value and at the first and second follow-up periods. A survival rate of 85.7% was found after 7 years of follow-up. Capsulodesis results in a low degree of meniscal extrusion in isolated lateral MAT fixed with a suture-only technique, which is maintained after 7 years of follow-up, with a high graft survival index (>85%) and satisfactory results on the functional scales.
Photocatalytic Decarboxylative Cyclization of 1,6-Enynes and N-Methacryloyl-2-phenylbenzimidazoles by Potassium Iodide/ Triphenylphosphine Catalysis
Authors: Ge Guo-Ping , Liu Hongxin , Wei Wen-Ting , Zhang Jian , Li Jiao-Zhe , Wang Ling-Tao , Yu Xuan-Chi , Zhang Jun-Hao 
Published: September 2022

AbstractWe describe a photocatalytic decarboxylative cyclization of 1,6-enynes or N-methacryloyl-2-phenylbenzimidazoles for efficient and ecofriendly syntheses of lactams or benzimidazo[2,1-a]isoquinoline-6(5H)-ones, respectively, by the use of KI/PPh3 as a redox catalyst system. In this method, N-hydroxyphthalimide esters were used as alkyl-radical precursors to achieve this decarboxylative cyclization without any dyes, transition-metal catalysts, oxidants, or bases.
Diagnostic Testing for von Willebrand Disease: Trends and Insights from North American Laboratories over the Last Decade
Authors: Ziemba Yonah C. , Abdulrehman Jameel , Hollestelle Martine J. , Meijer Piet , Plumhoff Elizabeth , Hsu Peihong , Selby Rita 
Published: September 2022

AbstractAccurate diagnosis of von Willebrand disease (VWD) depends on the quality, precision, and variability of the laboratory assays. The North American Specialized Coagulation Laboratory Association (NASCOLA) is a provider of external quality assessment (EQA) for approximately 60 specialized coagulation laboratories in North America. In this report, NASCOLA EQA data from 2010 to 2021 are reviewed for trends in methodology and precision among various assays. In particular, recent ASH ISTH NHF WFH (American Society of Hematology, International Society on Thrombosis and Haemostasis, National Hemophilia Foundation, and World Hemophilia Federation) guidelines for diagnosis of VWD are reviewed in light of EQA data. In contrast to other geographic regions, laboratories in North America predominantly use three-assay screening panels (antigen, platelet-binding activity, and factor VIII [FVIII] activity) rather than four-assay panels (antigen, platelet-binding activity, FVIII activity, and collagen-binding activity). They also use latex immunoassays rather than chemiluminescence immunoassays, and the classic ristocetin cofactor (VWF:RCo) assay and monoclonal antibody (VWF:Ab) assay to assess VWF platelet-binding activity over newer recommended assays (VWF:GPIbM and VWF:GPIbR). Factors that may be influencing these North American practice patterns include lack of Food and Drug Administration approval of the VWF:GPIbM, VWF:GPIbR, collagen binding assays, and chemiluminescence methodologies, and the influence of the 2008 National Heart, Lung, and Blood Institute guidelines on laboratory practice. Lastly, systems-based solutions are urgently needed to improve the overall accuracy of laboratory testing for VWD by minimizing preanalytical variables and adopting assay standardization.
Indian College of Radiology and Imaging Guidelines on Interventions in Hepatocellular Carcinoma
Authors: Gupta Pankaj , Kalra Naveen , Chaluvashetty Sreedhara B. , Gamangatti Shivanand , Mukund Amar , Abdul Razik , Shyam VS , Baijal Sanjay Saran , Mohan Chander 
Published: September 2022

AbstractHepatocellular carcinoma (HCC) is one of the most common malignancies and a significant cause of cancer-related death. Treatment of HCC depends on the stage of the tumor. As many patients with HCC are not deemed fit for surgical resection or liver transplantation, locoregional therapies play an essential role in the management. Image-guided locoregional treatments include percutaneous ablative therapies and endovascular therapies. The choice of an individual or a combination of therapies is guided by the tumor and patient characteristics. As the outcomes of image-guided locoregional treatments depend on the ability to achieve necrosis of the entire tumor along with a safety margin around it, it is mandatory to follow standard guidelines. In this manuscript, we discuss in detail the various aspects of image-guided locoregional therapies to guide interventional radiologists involved in the care of patients with HCC.
Medial Plica Syndrome of the Knee: Arthroscopic Plica Resection versus Structured Physiotherapy—A Randomized Controlled Trial
Authors: Sauer Steffen , Karlsen Gitte , Miller Lene , Storm Jens Ole 
Published: September 2022

Abstract
Background Medial plica syndrome is a commonly overlooked cause of anterior knee pain. A consensus on diagnosis and treatment is yet to be found. This study compares the clinical outcome of arthroscopic plica resection with structured physiotherapy for patients with isolated medial plica syndrome in a prospective randomized controlled trial with a 2-year follow-up.
Methods Forty-eight patients have been included in this prospective randomized controlled trial presenting medial plica syndrome. Patients were randomly assigned to either arthroscopic plica resection or structured physiotherapy. The primary outcome was the change in the average score of the Lysholm knee scoring scale from baseline to 2-year follow-up.
Results Mean baseline Lysholm score for patients assigned to arthroscopic plica resection and physiotherapy was 65.8 and 66.3, respectively. No significant difference was seen between the two groups. Thirty-three patients were assessed at 2 years follow up. The mean Lysholm score was 89.7 for patients assigned to arthroscopic plica resection and 74.6 for patients assigned to structured physiotherapy. A statistically significant difference was seen between the two groups (p = 0.007).
Conclusions Arthroscopic plica resection was associated with significantly greater clinical improvement compared with physiotherapy at 2-year follow-up.
Clinical Significance of Terminal Syringomyelia and Accompanying Congenital Anomalies of Neurosurgical Interest in Adult and Pediatric Patients with Tethered Cord Syndrome
Authors: Rakip Usame , Canbek İhsan , Yıldızhan Serhat , Boyacı Mehmet G. , Cengiz Akın , Aslan Adem 
Published: September 2022

AbstractMagnetic resonance imaging (MRI) can be used to examine tethered cord syndrome (TCS) and terminal syringomyelia (TS). Additionally, there is increasing evidence of an association between congenital anomalies and TCS. We aimed to identify the clinical and radiological characteristics of syringomyelia and other anomalies in pediatric and adult patients with TCS. This study included 54 TCS patients (mean age, 17.37 ± 15.83 years; 31 females) admitted to our department between 2010 and 2019. The patients were divided into two age groups: pediatric (<18 years; 63%) and adult (>18 years). Clinical findings, direct vertebrae radiographs, lower extremity radiographs, and spinal/cranial MRI findings were used to evaluate all patients. Computed tomography (CT) was performed to reveal the structure of the septum in patients with Diastematomyelia. Cranial ultrasonography or CT was performed if the fontanel was open or closed, respectively, in pediatric hydrocephalus cases. Pelvic ultrasonography and urodynamic tests were performed to evaluate other comorbid anomalies and urinary system pathologies. A thick filum terminale (73.3%) and diastematomyelia (44.4%) were found to cause spinal tension. The most common accompanying pathology was syringomyelia (78%). The common symptoms were urinary incontinence and bowel problems (71%), scoliosis (68%), and progressive lower extremity weakness (64.4%). It is difficult to distinguish the exact cause of symptoms in patients with TCS and TS. Due to the greater occurrence of other congenital spinal anomalies accompanying TCS, both preoperative symptoms and clinical findings are more severe in the pediatric group than in the adult group, and postoperative results may be more negative.
5.2.7 Product Subclass 7: Stannylenes
Authors: Takeda N. 
Published: September 2022

AbstractThis is a revised Science of Synthesis contribution describing methods for the synthesis of stannylenes. Substitution reactions of stable tin(II) compounds such as SnCl2, chlorostannylenes, and aminostannylenes with organolithiums are useful synthetic methods for preparing stannylenes. Insertion reactions of multiple bonds into Sn–X (X = H, B, C, Sn) bonds of hydrostannylene dimers, borylstannylenes, or distannynes can also afford the corresponding stannylenes. In addition, migration reactions of hydrogen, carbon, and amino substituents in (dihydrostannyl)germylene and tin–metal double-bond compounds are used for the synthesis of metal-substituted stannylenes. Finally, reduction of tetravalent tin compounds, such as dibromostannanes, has also been reported for the synthesis of stannylenes.
Avian community changes following drought-induced canopy collapse in a Mediterranean-type forest
Authors: Smithies Sean , Fleming Patricia A. , Bateman Philip W. , Hardy Giles E. St. J. , Dundas Shannon J. 
Published: September 2022

Context Extreme drought can result in the widespread die-off of forests and dramatically altered ecosystem structure. Such changes are likly to influence fauna using resouces within these forests. Aims Following a record hot and dry year/summer in 2010/11, large-scale canopy collapse occurred within a Mediterranean-type mixed jarrah (Eucalyptus marginata)–marri (Corymbia calophylla) forest in south-west Western Australia. We investigated the effects of this collapse on bird assemblages in 2016, 5 years after the initial collapse. Methods We carried out bird surveys using a standardised search method for five paired drought-affected and adjacent healthy forest plots. Key results A total of 3042 records of 51 bird species were observed across all surveys. Overall, the pooled (mean ± s.d.) reporting rates for drought-affected plots (13.84 ± 0.60 individuals/survey) were significantly less than the reporting rates for healthy plots (34.44 ± 1.03 individuals/survey) (PERMANOVA: F1 = 54.94, R2 = 0.31, P = 0.001). Species diversity was also higher in healthy plots (t26 = 11.21, P < 0.001). Foliage-searching birds were the most abundant guild across all plots and were reported less often in drought-affected plots (t6 = 2.70, P < 0.04). Conclusions Drought-affected jarrah forest plots exhibited significant differences in bird assemblages compared to healthy plots. Overall, the drought-affected forest provides a less favourable habitat for birds compared to healthy forest. Implications With marked variability and extreme climate events predicted for the future, understanding the impacts of such changes will contribute to how we manage forest ecosystems.
Sphingosine kinases regulate ER contacts with late endocytic organelles and cholesterol trafficking
Authors: Palladino Elisa N. D. , Bernas Tytus , Green Christopher D. , Weigel Cynthia , Singh Sandeep K. , Senkal Can E. , Martello Andrea , Kennelly John P. , Bieberich Erhard , Tontonoz Peter , Ford David A. , Milstien Sheldon , Eden Emily R. , Spiegel Sarah 
Published: September 2022

Membrane contact sites (MCS), close membrane apposition between organelles, are platforms for interorganellar transfer of lipids including cholesterol, regulation of lipid homeostasis, and co-ordination of endocytic trafficking. Sphingosine kinases (SphKs), two isoenzymes that phosphorylate sphingosine to the bioactive sphingosine-1-phosphate (S1P), have been implicated in endocytic trafficking. However, the physiological functions of SphKs in regulation of membrane dynamics, lipid trafficking and MCS are not known. Here, we report that deletion of SphKs decreased S1P with concomitant increases in its precursors sphingosine and ceramide, and markedly reduced endoplasmic reticulum (ER) contacts with late endocytic organelles. Expression of enzymatically active SphK1, but not catalytically inactive, rescued the deficit of these MCS. Although free cholesterol accumulated in late endocytic organelles in SphK null cells, surprisingly however, cholesterol transport to the ER was not reduced. Importantly, deletion of SphKs promoted recruitment of the ER-resident cholesterol transfer protein Aster-B (also called GRAMD1B) to the plasma membrane (PM), consistent with higher accessible cholesterol and ceramide at the PM, to facilitate cholesterol transfer from the PM to the ER. In addition, ceramide enhanced in vitro binding of the Aster-B GRAM domain to phosphatidylserine and cholesterol liposomes. Our study revealed a previously unknown role for SphKs and sphingolipid metabolites in governing diverse MCS between the ER network and late endocytic organelles versus the PM to control the movement of cholesterol between distinct cell membranes.
Fast acrobatic maneuvers enable arboreal spiders to hunt dangerous prey
Authors: Aceves-Aparicio Alfonso , Narendra Ajay , McLean Donald James , Lowe Elizabeth C. , Christian Marcelo , Wolff Jonas O. , Schneider Jutta M. , Herberstein Marie E. 
Published: September 2022

Spiders, the most specious taxon of predators, have evolved an astounding range of predatory strategies, including group hunting, specialized silk traps, pheromone-loaded bolas, and aggressive mimicry. Spiders that hunt prey defended with behavioral, mechanical, or chemical means are under additional selection pressure to avoid injury and death. Ants are considered dangerous because they can harm or kill their predators, but some groups of spiders, such as the Theridiidae, have a very high diversification of ant-hunting species and strategies [J. Liu et al.,Mol. Phylogenet. Evol. 94, 658–675 (2016)]. Here, we provide detailed behavioral analyses of the highly acrobatic Australian ant-slayer spider,Euryopis umbilicata(Theridiidae), that captures much larger and defendedCamponotusants on vertical tree trunks. The hunting sequence consists of ritualized steps performed within split seconds, resulting in an exceptionally high prey capture success rate.
Precision genome editing in the eye
Authors: Suh Susie , Choi Elliot H. , Raguram Aditya , Liu David R. , Palczewski Krzysztof 
Published: September 2022

CRISPR-Cas-based genome editing technologies could, in principle, be used to treat a wide variety of inherited diseases, including genetic disorders of vision. Programmable CRISPR-Cas nucleases are effective tools for gene disruption, but they are poorly suited for precisely correcting pathogenic mutations in most therapeutic settings. Recently developed precision genome editing agents, including base editors and prime editors, have enabled precise gene correction and disease rescue in multiple preclinical models of genetic disorders. Additionally, new delivery technologies that transiently deliver precision genome editing agents in vivo offer minimized off-target editing and improved safety profiles. These improvements to precision genome editing and delivery technologies are expected to revolutionize the treatment of genetic disorders of vision and other diseases. In this Perspective, we describe current preclinical and clinical genome editing approaches for treating inherited retinal degenerative diseases, and we discuss important considerations that should be addressed as these approaches are translated into clinical practice.
Interactional reciprocity in human–dog interaction
Authors: Simonen Mika , Lohi Hannes 
Published: September 2022

Abstract
This chapter explores the potential existence of
interactional reciprocity in human–dog interactions by analyzing
experimental data on situations where dog owners fail to produce
reciprocally modified actions for two minutes. We found that their
dogs soon realized the strangeness of the situation. While they
pursued missing feedback with touch, gaze and vocalizations, they
also addressed other humans and requested their attention.
Therefore, the dogs oriented to the lack of reciprocity and
attempted to repair it. We demonstrate that interactional
reciprocity in human–dog interactions can be breached, thus proving
its existence. Moreover, we show that it also returned when the
experiment ended. The findings are compared with mother–infant
experiments where evidence of interactional reciprocity has also
been found.