bluuebunny/crossref_metadata_2025_split huggingface dataset:
Baserer de såkaldte Bartholinannaler sig på danske middelalderlige årbøger?
Authors: Clausen Svend 
Published: January 2022

Svend Clausen: Are the Annales Bartholiniani based on Danish medievalannals?
The article discusses the so-called Annales Bartholiniani, written by the Danish scholarThomas Bartholin (1659‑1690). Analysis of a series of events that are clearly dated incorrectlyin the Annales Bartholiniani and a comparison of the dating of these eventswith the content of Danish medieval annals suggest that the inaccurate dating of suchevents in the Annales Bartholiniani must go back to the Danish medieval annalistictraditions. This proves that a great deal of the content of the Annales Bartholinianimust go back either directly or indirectly to the content of Danish medieval annals. Italso points to the fact that there needs to be more discussion of the Annales Bartholinianiin future studies, as they also contain a great deal of information not availableelsewhere, and the close link between them and the content of Danish medieval annalsmakes it much more likely that Bartholin may have used also some Danish medievalannals now lost in addition to the medieval annals still known to us. In this respect,such an identified close link between the Annales Bartholiniani and the known contentof the Danish medieval annalistic traditions may help significantly in explaining alsosome of the otherwise unknown information present in the Annales Bartholiniani.Discussions of the content for years such as 1087 and 1142, for example, suggest thatspecific details such as these may go back directly or indirectly to a now lost medievalDanish annalistic tradition.
Identification and validation of a novel signature for prediction the prognosis and immunotherapy benefit in bladder cancer
Authors: Zhang Yichi , Lin Yifeng , Lv Daojun , Wu Xiangkun , Li Wenjie , Wang Xueqing , Jiang Dongmei 
Published: January 2022

Background
Bladder cancer (BC) is a common urinary tract system tumor with high recurrence rate and different populations show distinct response to immunotherapy. Novel biomarkers that can accurately predict prognosis and therapeutic responses are urgently needed. Here, we aim to identify a novel prognostic and therapeutic responses immune-related gene signature of BC through a comprehensive bioinformatics analysis.

Methods
The robust rank aggregation was conducted to integrate differently expressed genes (DEGs) in datasets of the Cancer Genome Atlas (TCGA) and the gene expression omnibus (GEO). Lasso and Cox regression analyses were performed to formulate a novel mRNA signature that could predict prognosis of BC patients. Subsequently, the prognostic value and predictive value of the signature was validated with two independent cohorts GSE13507 and IMvigor210. Finally, quantitative Real-time PCR (qRT-PCR) analysis was conducted to determine the expression of mRNAs in BC cell lines (UM-UC-3, EJ-1, SW780 and T24).

Results
We built a signature comprised the eight mRNAs: CNKSR1, COPZ2, CXorf57, FASN, PCOLCE2, RGS1, SPINT1 and TPST1. Our prognostic signature could be used to stratify BC population into two risk groups with distinct immune profile and responsiveness to immunotherapy. The results of qRT-PCR demonstrated that the eight mRNAs exhibited different expression levels in BC cell lines.

Conclusion
Our study constructed a convenient and reliable 8-mRNA gene signature, which might provide prognostic prediction and aid treatment decision making of BC patients in clinical practice.
Contribution of the Characteristics of Farmers to use of Coping Strategies towards Household Food Security
Authors: Haque M. E. , Islam M. N. , Mostafa M.G. , Majid M. A. , Islam M. R. , Haque M. M. , Uddin M. Y. , Alam M. J. , Tasnim J. , Muhammad N. , Turin M. Z. 
Published: January 2022

A study was carried out at each of three flood affected reverine villages of three upazilas (small administrative unit) under Jamalpur district in Bangladesh during September, 2011 to May, 2012 to find out the contribution of the characteristics of the farmers to the use of coping strategies towards household food security practiced by the farmers during flood. Data were collected from randomly selected 336 respondents both the qualitative and quantitative techniques and analyzed with the help of SPSS. Out of 18 characteristics, 11 had positive, 2 had negative and 5 had no significant relation with coping strategies towards household food security during flood period. Stepwise regression analysis revealed that six variables namely participation in income generating activities (IGAs) (20.1 percent), knowledge on flood coping mechanisms (8.5 percent), cosmopoliteness (6.5 percent), utilization percentage of received credit (2.0 percent), water and sanitation condition (1.6 percent) and year round household food situation (0.8 percent) were the major contributing variables which combindly explained 39.5 percent of total variations. Path analysis revealed that knowledge on flood coping mechanisms had the highest positive direct effects (0.285) and participation in IGAs had highest positive indirect effects (0.169) on coping strategy practices. Considering the relative contribution on the coping strategy practices towards household food security during flood period, based on their direct effects, the six variables could be arranged as follows knowledge on flood coping mechanism > participation in income generating activities > cosmopoliteness > water and sanitation condition > year round household food situation > utilization of received credit.
Consumers’ Level of Awareness and Safety Perceptions of Food Additives
Authors: Al-Ghamdi Badrah , Al-Tabsh Ghidah , Al-Deibani Alaa , Al-Muhanna Rahaf , Gari Shahlaa , Khayyat Nusaiba 
Published: January 2022

Aims: We aimed to measure the prevalence of Jeddah residents’ knowledge and their awareness of these ingredients.
Study Design: A cross-sectional study.
Place and Duration of Study: The study conducted in Jeddah, Saudi Arabia, during 2019.
Methodology: This study was cross-sectional via an electronic survey that was handed out, and 676 of 868 respondents fit the inclusion criteria: all individuals were eighteen and above in addition to residing in Jeddah in 2019. Statistical analysis was performed using SPSS version 21. Pearson's chi-square was used to test association.
Results: The results showed that 63.5% of consumers needed more information about food additives. About 80.5% were familiar with preservatives which, in their opinion, were the most disconcerting food additives. Moreover, 37.2% desired easier and accurate labels to gain a better understanding of this topic, while 43.6% said that the most acceptable idea for disseminating information about food additives to the public was by animation in independent display areas.
Conclusion: The study’s findings are examined in terms of the implications for future research and for the development of concrete communication materials to improve food additive awareness in Jeddah, Saudi Arabia. The level of knowledge was low. Further studies are needed to be done in Saudi Arabia about this topic.
COVID-19 in Diabetes Patients
Authors: Rugvedh Padigela , Wadbudhe Akshad , Damke Smita 
Published: January 2022

The 2019 coronavirus pandemic (COVID19) infected more than twenty-two point seven million human and resulted in the causalities of seven lakh ninety-five thousand people throughout the world. Diabetics are more prone to hitches and side effects caused by COVID19. The COVID19 pandemic overlaps with the already present high blood glucose pandemic that will produce bulky and suggestively more prone residents with high blood sugar levels and COVID19. This article will provide an outlook of the irrefutable suggestion for subordinate experimental products of COVID19 disease in diabetics compared to healthy individuals, including in specific group of individuals, such as broods, pregnant women, cultural minorities and folkloric. It also discusses similarities connecting COVID19 and it suggests that difficulty or pre-existing conditions in diabetics may exacerbate the infection process. Finally, this paper describes the outlook for chronic sequelae after COVID19 for more prone groups of diabetic individuals.
The year 2019 was hit by a very miserable disease which turned into, a contagion known as COVID19 caused by SARSCOV2 it is a ribonucleic B infective particle. The infected people have self-limiting symptoms, mature publics and the people with other related health disorders were under high hazard, also the impermanence rate was high among them. There were many and some were asymptomatic, the medical professionals advised them to isolate themselves and monitor the clinical symptoms.
The insignificant warning sign affected role were given supportive care and isolation in ambulatory setting Mature patient role those with other health disorders were closely scrutinized until clinical recovery was achieved. The COVID19 pandemic was terminal.
Pharmacology of Cisatracurium Besylate
Authors: Kumar Vasam Rajesh , Ninave Sanjot , Chakole Vivek 
Published: January 2022

Background: In routine anesthesia practice, a variety of neuromuscular blocking agents are used. Cisatracurium besylate is a nondepolarizing neuromuscular blocking agent with an intermediate duration of action. Because of the high molecular weight and polarity, the volume of distribution is small. Cisatracurium besylate undergoes Hofmann elimination, making it an excellent choice for patients suffering from organ failure.
Methodology: This review article was prepared after a thorough study of the literature using data search engines such as Scopus, Pubmed, Web of Science, and Google Scholar. This article referred to prior Cisatracurium observational studies and case reports.
Review Findings: After learning pharmacology, uses, contraindications of Cisatracurium and reviewing the previous observational studies and case reports about Cisatracurium, this drug is used as a muscle relaxant during general anesthesia for tracheal intubation. It has been used successfully in critical care settings where patients were placed on mechanical ventilation and required complete skeletal muscle paralysis. Systemic or cutaneous release of histamine is not caused by cisatracurium.
Conclusion: Cisatracurium is a relatively new intermediate-onset, long-lasting skeletal muscle relaxant. This medication can be used safely in patients with hepatorenal impairment. It, like other muscle relaxants, can be used during elective surgical repair under general anaesthesia as well as in patients undergoing prolonged controlled mechanical ventilation. The only concern could be the cost effectiveness in comparison to other skeletal muscle relaxants on the market.
Evaluation of Antioxidant and Xanthine Oxidase Inhibitory Potential of Methanolic Root Extract of Acorus calamus- an In vitro Study
Authors: Ahmed Ashfaaq , Gayathri R. , Priya V. Vishnu , Selvaraj J. , Kavitha S. 
Published: January 2022

Background: Gout is an inflammatory joint disease that elevates the uric acid levels in blood that triggers the formation of urate crystals in the joint,especially since the past 50 years. Xanthine oxidase catalyses oxidative hydroxylation of hypoxanthine to Xanthine to uric acid. show it's higher in men aged above 50 years. Acorus calamus is a mid term, perennial, fragrant herb. Therefore, the main approach for the treatment of gout is reducing uric acid.
Aim: To analyze the antioxidant and Xanthine Oxidase inhibitory potential of methanolic root extract of Acorus calamus.
Materials and Methods: Preparation of methanolic root extract of Acorus calamus was done by hot percolation method. Phytochemical screening test was done. The antioxidant activity was carried out by DPPH radical scavenging assay. Anti gout potential of the herbal extract was analysed by the evaluation of Xanthine oxidase inhibitory potential. The data were analyzed statistically by a one-way analysis of variance (ANOVA) followed by Duncan’s multiple range test to see the statistical significance among the groups. The results with p<0.05 level were considered to be statistically significant.
Results: Methanolic root extract of Acorus calamus shows a strong presence of phytochemicals such as alkaloids ,terpenoids, steroids, saponins, flavonoids.IC50 of antioxidant potential of Methanolic root extract of Acorus calamus was found to be 210 µg/ml.Ic 50 of xanthine oxidase inhibitory potential of methanolic root extract of Acorus calamus was found to be 310 µg/ml.
Conclusion: Methanolic root extract of Acorus calamus exhibited significant antioxidant and anti gout potential. Further research on the natural Xanthine oxidase inhibitors especially in vivo studies and investigation of active compounds and its pharmacokinetics to be elucidated.
Effect of Radiotherapy on Microhardness and Surface Morphology of Pretreated Primary Teeth with Silver Diamine Fluoride: An In vitro Study
Authors: Das Simran , Thosar Nilima , Rathi Nilesh , Khubchandani Monika 
Published: January 2022

Background: Radiation therapy has proven to be an effective modality in treating children suffering from cancer. High prevalence of dental caries is seen in children undergoing radiation therapy. This is primarily due to the direct effects of these harmful radiation on the enamel and not as a consequence to the reduced salivary flow. Mechanical properties of the enamel have been seen to be affected by radiation according to various studies conducted.
Objectives: The objective of this study is to evaluate whether radiotherapy causes changes in the microhardness and surface morphology of enamel in primary teeth pretreated with silver diamine fluoride.
Methodology: 22 primary teeth samples will be divided into two groups, 11 samples each-study group which will be pretreated with silver diamine fluoride (SDF) and control group. Both groups will be subjected to radiotherapy of 10 Gy radiation for a duration of 6 days. The samples will be tested for Vickers microhardness test and SEM analysis for surface morphological changes post radiotherapy. Statistical analysis will be done using “chi square test, paired and unpaired student t -test”. Surface microhardness and morphological changes of the study and control group compared.
Expected Results: It is expected that SDF application will be effective modality in prevention of caries due to frequent radiation exposure in children suffering from cancer and undergoing radiotherapy.
Conclusion: The study will conclude that SDF will cause a reduction in the microhardness of the surface and lesser morphological changes in the enamel of the primary teeth post radiation therapy in children suffering from cancer.
Synthesis, Anti Cancer and Anti Fungal Studies of New Phenyl Ethylene Derivatives
Authors: Phanikumar V. S. R. N. , Reddy M. Kiranmai , Sharma G. Veera Raghava 
Published: January 2022

Synthesis of Phenyl ethylene derivatives (4a-4f ) are reported in this communication. Products were characterized by1HNMR, Carbon (13C) NMR and Mass spectral data. Synthesized compounds of 4a-4f were screened for anti cancer and anti fungal activities and their results are presented. The main intermediate (3) was prepared from 4-methoxy phenyl acetone (1) reacted with aqueous ethylamine and NaBH4 to get the compound (2).Further dehydrohalogenation of (2) with 4-bromobutanol and potassium carbonate at 80°C resultedin compound (3)which on further dehydration with p-toluene sulfonic acid under reflux conditionsgave 4a to 4f.
Impact of Superior and Inferior Approach in Identification and Preservation of Spinal Accessory Nerve during Modified Radical Neck Dissection in Patients with Oral Squamous Cell Carcinoma
Authors: Pandya Naman , Jadhav Anendd , Bhola Nitin , Khare Naman 
Published: January 2022

Background: During neck dissection, injuries to spinal accessory nerve (SAN) are most common cause of post-operative shoulder morbidity. Which is known as ‘Shoulder Syndrome’. Despite the evolution in neck dissection procedures from radical to super-selective neck dissection, post-operative shoulder dysfunction remains a point of exasperation for head and neck surgeons. It significantly impacts the standard of living for patients with head and neck cancer. According to the anatomic course and branching of SAN, there are various dissection technique for identification and preservation. Our comparison of superior dissection approach with inferior dissection approach for identification, preservation, and complete skeletonization of SAN in posterior neck dissection has not been studied based on its anatomical course.
Objective: To compare Superior Vs. Inferior approach group in regards to safety and superiority of the approach for SAN preservation with minimal or no intraoperative and or post-operative functional complications.
Methods: The patients will be randomly divided into two groups according to the approach used to identify and preserve SAN (superior Vs. inferior approach group). The intraoperative clinical and post-operative data will be collected and evaluated with appropriate statistical analysis.
Results: Collected data from 24 patients will undergo statistical analysis to obtain the results.
Conclusion: This study expects to find a superior modality amongst the Superior dissection approach and inferior dissection approach in terms of identification, preservation, and post-operative functional deficit for spinal accessory nerve.
A Study Design for Awareness Regarding Appropriate Antimicrobial use and Antimicrobial Resistance among Health Care Professionals and Lay Persons
Authors: Turankar Tileshkumar , Gaidhane Shilpa , Choudhari Sonali G. , Gaidhane Abhay , Sawale Shantanu Raju 
Published: January 2022

Aim: This study is designed to determine the awareness of anti-microbial resistance and appropriate antimicrobials use among health care professionals (intern, junior residents and nurses) and lay persons.
Methods: The study will be held at rural tertiary care hospital in central India including junior resident, Interns and nurses, patient and their relatives. Survey tool and data questionnaire will be provided to participants in English and Marathi.
Results: Comparison of knowledge of antimicrobial resistance among hospital staff, patient and their relatives will be done.
Conclusion: There is a need to frame policies to prevent excessive use of Antimicrobials and to increase awareness about the knowledge of proper usage antimicrobial and antimicrobial resistance among lay person.
A Brief Overview of Diabetic Retinopathy
Authors: Rajput Aditi , Mankar Sejal , Banait Shashank 
Published: January 2022

Diabetic Retinopathy (DR) and diabetic macular oedema are caused by multiple retina's capillary changes and increased retinal blood vessels permeability, which contributes to the emergence These treatments aren't always beneficial in all patients, and possible adverse effects can linger in a considerable number of people. One of the mechanisms that is found is the plasma kallikrein-kinin system (KKS). The formation of intraocular KKS causes retina’s capillary permeability, vascular dilation, and retinal thickening in preclinical investigations. possibly distinct physiologic pathways, according to proteomic study from the vitreous of eyes with DME. Furthermore, proteins linked to substantially more closely linked to the KKS route than discovered to be an effective way to reduce diabetic mice in preclinical investigations. An early phase I human study of a new plasma KKS inhibitor for the management of DME is now underway to assess the approach's safety and serve as a first step in translating basic science discoveries into a novel therapeutic involvement. Many years of study of the etiology plus treatment has transformed our understanding of the condition. Because neurodegenerative illness precedes and coexists with microvascular alterations, diabetic retinopathy is characterised as a neurovascular disease rather than a capillary disease. The intricacies of the pathways implicated in various phases of disease severity, on the other hand, continue to be a difficult challenge for drug development. Laser photocoagulation is now one of the best investigation for treating proliferative diabetic retinopathy, however it is rapidly being phased out for diabetic macular oedema. Inhibitors of vascular endothelial growth factor, which were recently discovered, are changing the treatment of diabetic retinopathy, particularly diabetic macular edema . Anyhow, anti-vascular endothelial growth factor medicines do not work in all individuals, highlighting the reality that diabetic retinopathy is a complex illness. To improve our perceptive of how retinal anatomy affects visual function, more research is needed. This is expected to contribute to a greater knowledge of the disease phenotype based on therapy reactions to specific drugs, and also the creation of a strategy to improve the company of different phases of seriousness. In the Diabetes control and complications trial (DCCT) main preventive and secondary intervention cohorts were found to be older at baseline than the WESDR groups, with an elderly age of finding, a lower haemoglobin A1c (HbA1c) level, and more recurrent injections and monitor, but there were few other significant changes.
Fast Self‐Assembly of Scalable Photonic Cellulose Nanocrystals and Hybrid Films via Electrophoresis
Authors: Atifi Siham , Mirvakili Mehr‐Negar , Williams Cyan A. , Bay Mélanie M. , Vignolini Silvia , Hamad Wadood Y. 
Published: January 2022

AbstractNano‐enabled, bio‐based, functional materials are key for the transition to a sustainable society as they can be used, owing to both their performance and nontoxicity, to gradually replace existing nonrenewable engineering materials. Cellulose nanocrystals (CNCs), produced by acid hydrolysis of cellulosic biomass, have been shown to possess distinct self‐assembly, optical, and electromechanical properties, and are anticipated to play an important role in the fabrication of photonic, optoelectronic, and functional hybrid materials. To facilitate CNCs’ technological viability, a method suitable for industrial exploitation is developed to produce photonic films possessing long‐range chirality on conductive, rigid, or flexible, substrates within a few minutes. The approach is based on electrophoretic deposition (EPD)‐induced self‐assembly of CNCs, where photonic films of any size can be produced by controlling CNC surface properties and EPD parameters. CNC film coloration can be determined by the CNC aqueous suspension characteristics, while their reflected intensity can be tuned by changing the duration and number of electrodeposition cycles. EPD‐induced self‐assembly of CNCs is compatible with in situ reduction of gold precursors without the need to use additional reducing agents (some of which are considered toxic), thereby allowing the preparation of hybrid photonic films with tunable plasmonic response in a one‐pot process.
Metal–Semiconductor–Metal Metasurface for Multiband Infrared Stealth Technology Using Camouflage Color Pattern in Visible Range
Authors: Kim Jagyeong , Park Changhoon , Hahn Jae W. 
Published: January 2022

AbstractOptical stealth technology is being developed to cope with high‐sensitivity infrared image detectors and various guided detectors. Infrared stealth technology has remarkable performance; however, future advancements in multi‐band stealth technology covering the entire optical frequency range, from visible to wide infrared, are key challenges regarding unmanned surveillance systems. Thus, a metal–semiconductor–metal (MSM) metasurface with Fabry–Pérot (F–P) and multiple plasmonic resonant modes is introduced to realize multiband stealth technology. Different colors are obtained for printing camouflage patterns in the visible range using localized surface plasmon modes in Al disks on an opaque Ge layer. The F–P resonance of the Ge layer induces a strong absorption of >92% at 1.06 µm, reducing the guidance signal of the infrared laser‐guided detector. With an additional plasmonic resonance in the MSM metasurface, infrared signature reductions of >34%, >94.4%, and >97.7% are obtained for short‐wave, mid‐wave, and long‐wave infrared bands, respectively.