bluuebunny/crossref_metadata_2025_split huggingface dataset:
RP-HPLC-METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF DEXKETOPROFEN TROMETAMOL AND TRAMADOL HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORM
Authors: SUSMITHA P. , NEELIMA CH. , HEMASRI M. , LAKSHMI S. SRI 
Published: July 2022

Objective: For the measurement and quantification of Dexketoprofen Trometamol and Tramadol Hydrochloride, a rapid, sensitive, and reliable RP-HPLC technique using the Waters HPLC System with PDA detection was designed and validated.
Methods: Chromatography was carried out on an Inertsil-ODS C18 (250 x 4.6 mm, 5) column with a flow rate of 1.0 ml/min and effluent of 240 nm using filtered and mixed Degassed Methanol: Buffer (75:25) v/v as a mobile phase.
Results: Dexketoprofen Trometamol and Tramadol hydrochloride has a retention time of 3.617 min and 5.013 min, respectively. % recovery for Dexketoprofen trometamol and tramadol hydrochloride was found to be 100.21% and 100.20%, respectively. LOD and LOQ values obtained for Dexketoprofen trometamol and tramadol hydrochloride are 0.074µg/ml, 0.225µg/ml and 0.175µg/ml, 0.531µg/ml respectively. Regression equation of Dexketoprofen trometamol is y = 7446.1273x-284.0702 and y = 39535.8782x-1580.4211 of Tramadol hydrochloride.
Conclusion: Dexketoprofen trometamol and tramadol hydrochloride has developed and validated in pharmaceutical dosage form using RP-HPLC method.
MOLECULAR DOCKING AND ADMET STUDIES OF BENZOTRIAZOLE DERIVATIVES TETHERED WITH ISONIAZID FOR ANTIFUNGAL ACTIVITY
Authors: AISWARIYA  , B. V. SUMA , SATYA MEDICHARLA SRI 
Published: July 2022

Objective: The incidence of fungal infections is increasing at an alarming rate, presenting an enoromous challenge to health care professionals. This increase is directly related to the growing population of the immunocompromised individuals, resulting from changes in the medical practice such as the use of intensive chemotherapy and immunosuppressive drugs. The ability of many fungi to form biofilms is one of the reasons for the antifungal resistance caused and hence there is an urgent need in the synthesis of new and safer anti-microbial agnets. Benzotriazole is an organic heterocyclic compound with 2 nitrogen atoms in the ring having wide range of biological properties like anti-tubercular, anticancer and anti-microbial etc. isoniazid is the first line drug used to treat tuberculosis. Tethering benzotriazole with isoniazid has shown development of newer compounds that may exhibit better activity on inhibiting the fungal growth and replication and hence has shown a positive effect on the anti-fungal activity.
Methods: Affinity between the protein and ligand was found out using rigid docking technique.3D structure of the fungal protein was downloaded from protein data base. The selected ligand molecules are generated using Chem Draw. ADMET studies for the molecules are determined using SWISS-ADMET website. Rigid docking is employed to find the binding affinities between ligand and protein.
Results: 4 derivatives of benzotriazole tethered with isoniazid were selected and docking studies were carried out for these compounds with the antifungal protein,14 alfa-demethylase with PDB I. D; 5V5Z,using molecular docking tool PyRx and docking scores were-8.3,-7.6,-9.2,-7.4 respectively when compared with the standard compound Fluconazole (-8.0). ADMET studies of the 4 compounds have shown zero violation to lipinski’s rule.
Conclusion: In summary, benzotriazole derivatives tethered with isoniazid exhibits promising results based on in silico studies. ADMET studies showed that the compounds drug likeness parameters are according to lipinski’s rule of five.
Primary disease incidence with officers of the Russian aerospace forces and navy (2015–2020)
Authors: Evdokimov V. I. , Mosyagin I. G. , Sivashchenko P. P. 
Published: July 2022

OBJECTIVE: Comparative analysis of medical statistical indicators of primary disease incidence with officers of the Russian Aerospace Forces (ASF) and Navy from 2015 to 2020.MATERIALS AND METHODS: There was a comparative statistical analysis of medical reports on health status of the personnel and medical service activity on the form 3/MED of military units, in which not less than 80% of the total number of Russian military officers did service. Disease incidence data was weighed against the classes of International statistical classification of disease and health issues, 10th revision (ICD-10) and calculated for 1000 officers or in ‰.RESULTS AND DISCUSSION: The annual average level of primary disease incidence with ASF officers in 2015–2020 was 500,7±28,1‰, Navy officers — 364,4±20,1‰ (p<0,01). Polynomial trend of primary disease incidence level among ASF officers resembles an invertible U-curve with maximum data in 2016–2018, Navy officers — shows data increase. There are indicators of primary disease incidence with officers according to disease classes and leading nosology. Disease incidence among ASF and Navy officers were compared.CONCLUSION: Accounting of primary disease incidence will help to carry out disease preventive measures and forecast a calculation of the forces and medical service facilities.
Аssessment of the influence of physical factors of the external environment on the heat feeling of a human in the conditions of Kamchatka
Authors: Rakhmanov R. S. , Spirin S. A. 
Published: July 2022

OBJECTIVE: Characterize the climate impact on the population of Petropavlovsk-Kamchatsky regarding warmth sensation in different periods of the year.MATERIALS AND METHODS: The length of a warm and cold period of the year was determined. Based on mean monthly temperatures, relative humidity, wind speed, maximum wind and minimum temperature, taken from the website of weather condition records in Petropavlovsk-Kamchatsky for 2010–2020, the equivalent-effective temperature (EET) has been calculated that allows to estimate the warmth sensation of a man, stripped to the waist.RESULTS AND DISCUSSION: According to the average temperature, the warm period is in June-September, the cold one is 8 months. As for EET, thermal comfort is in July-August; it’s cool in June and September; it’s cool/moderately cool in October; it’s moderately cool in April-May and November; it’s very chilly in December-March. Speaking about minimum temperature and maximum wind, it’s warm in August, warm/cold in September; 10 months is a cold period of the year. By comparing EET, it’s cool in July and August; it’s moderately cool in May, June, September and October; it’s very chilly in April and November, moderately cold in December and March and cold in January. In February conditions are moderately cold/cold.CONCLUSION: Amidst high humidity the wind produces a meaningful effect on a bioclimatic discomfort.
Decision-making style and emotional intelligence in post-COVID young people
Authors: Ulyukin I. M. , Rassokhin V. V. , Sechin A. A. , Orlova E. S. 
Published: July 2022

OBJECTIVES: To study the interrelationships of decision-making style as a reflection of individual differences in coping with uncertainty and emotional creativity as a factor of self-realization in young people who have had COVID-19.MATERIALS AND METHODS: We examined 100 convalescents aged 18.2±2.25 years, including 50 men (Group M) and 50 women (Group G) (the age difference between the groups is not significant). The main transferred clinical forms of COVID-19 were the inapparent form — 42.0% (group M — 32 people, group G — 10 people), acute respiratory viral infection — 56.0% (group M — 17 people, group G — 39 people) according to the Russian versions of the Melbourne Decision Making Questionnaire (MDMQ) and the Emotional Creativity Inventory (ECI).RESULTS AND DISCUSSION: In both groups of examined individuals after suffering COVID-19 in all clinical forms of the disease, the «vigilance” strategy, considered as productive, is of the greatest importance in the decision- making process; unproductive strategies are not expressed, which is important for the subsequent medical and psychological support of convalescents. It is noted that the interaction between the factors of emotional creativity is expressed not only in an increase in creativity when high values coincide on two or more faces, but also in the fact that low values of one component can be compensated by high values of another.CONCLUSION: The data obtained are important for conducting medical and psychological support for convalescents and for preventing the formation of professional burnout, and for quick adaptation to various life situations, and for motivation to prevent the occurrence of changes in functional states after suffering COVID-19.
Introduction of preventive nutrition based on local raw foodproducts for rotational employees in the Arctic region: a review
Authors: Degteva G. N. , Gudkov A. B. , Novikova I. I. , Shepeleva O. A. , Popova O. N. 
Published: July 2022

OBJECTIVES: To identify the nutritional characteristics of fly-in fly-out workers in the Arctic on the basis of literature sources analysis and the results of our own research, and to judgethe use of food products of local origins.MATERIAL AND METHODS: Data extraction and synthesis from the scientific electronic library Elibrary.ru, RSCI and CyberLeninka, on the study of daily diets for rational employees working in the Arctic are analyzed.RESULTS: The actual nutrition of rational employees during the shift in the Arctic does not fully meet the principles of full value, balance and variety. The quantitative side of the daily diet provides an energy balance, but the qualitative component of the food consumed requires correction. Thus, the need for proteins is provided mainly by meat dishes and lack of fish and seafood. The ratio between animal and vegetable fats is disturbed in favor of animal fats. A deficiency of calcium and vitamins, especially vitamin C, was found in daily ration in the spring season. Vegetables, fruit drinks, and fruits are hardly ever present in daily ration. To improve the quality of rational employees’ nutrition, it is necessary to use widely the products of the local raw material base, such as venison, fish and berries. Venison has an amino acid score close to an ideal protein, and reindeer fat increases the body’s resistance to the cold factor. Fish is an important source of complete protein, as well as a carrier of essential fatty acids of the omega 3, which reduce the risk of cardiovascular disease and vascular accidents. Northern berries contain minor bio-active substances that are involved in the regulation of metabolic processes, have antisclerotic, anti-inflammatory effects, as well as reduce the likelihood of thrombosis and strengthen capillaries.CONCLUSION: The diet of shift workers in the Arctic, which does not fully meet all the principles of rational nutrition, should include products of the local raw material base, such as venison, fish and northern berries, which will improve the quality side of nutrition.
Вreathing in helium-oxygen gas mixtures as a means of emergency restoration of the working capacity of specialists of hazardous occupations
Authors: Stroy A. V. , Lobozova O. V. , Danilevich G. D. , Skokova V. Yu. , Afendikov S. G. , Tanova A. A. , Antonova A. V. 
Published: July 2022

OBJECTIVES: To evaluate the effectiveness of using helium-oxygen breathing mixtures for emergency restoration of the working capacity of specialists of hazardous occupations.MATERIALS AND METHODS: 18 male military personnel (age 25–40 years), divided into the main group and the comparison group (9 people each). All servicemen showed signs of decreased efficiency. In the main group, a procedure of 40-minute breathing with a heated gas mixture with an Oxygen content of 25% vol., Helium content of 75% vol. was prescribed. The comparison group underwent standard 40-minute Oxygen therapy.RESULTS: Using of helium-oxygen gas media demostrated much more effective means of emergency restoration of the work capacity of specialists than oxygen therapy. This was evidenced by the better dynamics of physical performance indicators and the level of physiological reserves in the main group.CONCLUSIONS & DISCUSSION: Helium-oxygen therapy can be considered as an effective and safe method of restoring working capacity, applicable in the «field» conditions.
Industry 4.0-Enabled Environment, Social, and Governance Reporting: A Case from a Chinese Energy Company
Authors: Yu Wenjun , Gu Yu , Dai Jun 
Published: July 2022

ABSTRACT
Accelerating climate change, deforestation, and pollution have turned a global spotlight on corporate sustainability. Many countries have issued standards on Environment, Social, and Governance (ESG) reporting, especially from heavily polluting companies. ESG disclosure has become a main channel for investors, the public, and other external stakeholders to understand companies’ impact on the environment. However, the current methods of collecting and processing environmental information are insufficient and infrequent, impairing stakeholders’ decision-making. Moreover, the complexity and diversity of environmental measures can inhibit information reliability, accuracy, and objectivity. We propose the use of Industry 4.0 technologies to improve existing ESG reporting processes and demonstrate a novel environmental reporting system that could allow a Chinese energy company to collect and report environmental information in real time, enhancing the completeness, reliability, and efficiency of their environmental disclosure.
Implikasi Prosedur Pencatatan Perkawinan pada Masa Pemberlakuan Pembatasan Kegiatan Masyarakat (PPKM) Perspektif Fiqih Nusantara
Authors: Anshor Ahmad Muhtadi 
Published: July 2022

Kajian ini bertujuan untuk menganalisa bagaimana implikasi prosedur pencatatan perkawinan pada masa pemberlakuan pembatasan kegiatan masyarakat (PPKM) dalam perspektif fiqih Nusantara. Penelitian ini tergolong dalam penelitian studi pustaka dan menggunakan analisis konten, disamping itu juga peneliti melakukan penggalian data dengan observasi dan wawancara kepada pihak yang terkait secara langsung dengan tema penelitian ini. Hasil penelitian menunjukkan bahwa implikasi prosedur pencatatan perkawinan pada masa PPKM yakni adanya penundaan perkawinan dan perkawinan siri. tindakan ini jika ditinjau dalam perspektif fiqih Nusantara, berbeda dengan tindakan penundaan perkawinan, sebaliknya perkawinan siri tidak bisa dibenarkan. Karena secara esensi fiqih Nusantara mengimplementasikan maqashid syari’ah berupa pencegahan kemudharatan dan perwujudan kemaslahataan. Penundaan perkawinan dipandang sebagai bentuk penerapan maqashid syari’ah, sedangkan Perkawinan siri selain sebagai bentuk ketidakpatuhan kepada peraturan pemerintah, tindakan ini juga akan berpotensi menimbulkan masalah terkait pemenuhan hak dan kewajiban bagi rumah tangga dikemudian hari.
La literatura infantil y juvenil de autor en los libros de texto de Educación Primaria
Authors: Ortiz Ballesteros Antonia María , Gómez Rubio Gema 
Published: July 2022

En este trabajo se presentan las conclusiones de una investigación realizada a partir de la última edición de los libros de texto de la asignatura Lengua castellana y Literatura, publicados por cuatro editoriales con larga tradición y uso actual, con el fin de analizar la presencia y el tratamiento que recibe en ellos la Literatura infantil y juvenil (en adelante LIJ) y delimitar si el repertorio de obras literarias que incluyen tiene como referencia o puede constituir en sí mismo un canon.
Transformative Learning for Sustainability Practices in Management and Education for Sustainable Development: a Meta-Synthesis
Authors: Viera Trevisan Laís , Mello Samuel Ferreira de , Pedrozo Eugênio Ávila , Silva Tânia Nunes da 
Published: July 2022

Purpose: This study aims to analyze how transformative learning (TL) theory has contributed to sustainability practices in management and Education for Sustainable Development (ESD) and what kind of strategies can direct future practices in the field.

Method/design/approach: An exploratory and inductive study to synthetize primary qualitative case studies was conducted. After screening 241 articles extracted from the Web of Science database, we identified 13 empirical papers highlighting TL theory and sustainability. Then, a meta-synthesis of these qualitative case studies was conducted based on the key characteristics of TL.

Results and conclusion: Six theoretical propositions were elaborated, showing that the TL theory has contributed to sustainability through some influential factors on process, conditions, and results. In addition, based on these dimensions, the study provides some strategies for future practices.

Research implications: The findings of this study have both theoretical and practical contributions, which can direct organizational and educational politics and practices.

Originality/value: Sustainability and ESD are current topics in the academy in favor of the Sustainable Development Goals (SDGs). However, there is a lack of studies on the development of theoretical strategies towards sustainability practices in management and ESD from a transformative learning TL approach. Thus, this study shed more light on the topic.
Flow alteration therapy for impending rupture of intracranial giant aneurysm after flow diverter placement
Authors: Yamasaki Daichi , Fukuda Hitoshi , Hamada Fumihiro , Kida Namito , Fukui Naoki , Okada Kenji , Masahira Noritaka , Ohta Tsuyoshi , Imamura Hirotoshi , Sakai Nobuyuki , Ueba Tetsuya 
Published: July 2022

Background:
Flow diverter (FD) placement is generally effective for intractable internal carotid artery (ICA) aneurysms. However, salvage treatment for the aneurysm enlarging even after FD placement remains to be elucidated. Additional overlapping FD placement is considered the first-line treatment for residual or recurrent aneurysms. However, it is unclear whether overlapping FD is also effective for enlarging giant aneurysms that are considered impending rupture status. Although parent artery occlusion is a promising option, treatment strategy must be optimized, especially when a critical perforating artery is involved.

Case Description:
A 74-year-old woman experienced rapid symptomatic growth of her giant supraclinoid ICA aneurysm 10 months after FD placement. We assumed that reinforcement of flow diverting effect alone would be less effective for this extremely intractable aneurysm with more aggressive clinical feature so that surgical bailout by parent artery occlusion was planned. Complete ICA obliteration underneath the aneurysm was unavailable due to the presence of anterior choroidal artery. Thus, we took a flow alteration strategy, where we created minimal retrograde flow through the parent artery by a combination of an extracranial-intracranial bypass and targeted endovascular proximal parent artery obliteration, resulting in prevention of aneurysmal rupture and further growth.

Conclusion:
Impending rupture of the intracranial giant aneurysm after FD placement may be controllable with a tailor-made parent artery occlusion strategy even when a critical perforating artery is involved.
Tree Diversity has Limited Effects on Beech Bark Disease Incidence in American Beech Population of Mont St-Hilaire
Authors: Zhang Zhihong , Perez Ema , Chinn Anna , Davies Johnathan 
Published: July 2022

Background: American beech trees (Fagus gandifolia) exist in many areas in northeastern North America. Beech bark disease (BBD) is caused by a scale insect and bark-killing fungus (Cryptococcus fagisuga and Nectria spp.). We aim to study the correlation between diversity and the presence of BBD, and predict that tree diversity in Gault’s Nature Reserve in Mont St-Hilaire (MSH), Québec decreases the presence of BBD and that F. grandifolia density would increase the presence of this disease.
Methods: We randomly chose 15 sites for sampling of individual tree species. F. grandifolia trees were identified as “healthy” or “infected”. Simple regressions, ANOVA, two and three-way interaction, linear mix effect model, and paired t-test were performed using R and Excel.
Results: Our results show no significant correlation of infected individuals and total number of either A. saccharum or A. pensylvanica, unless analyzed with a linear mixed effect model (p=0.0256). However, there was a strong, positive correlation between the number of infected trees and the density of F. grandifolia (R2=0.6712), and this relationship was stronger in disturbed areas compared to undisturbed areas in the reserve (t=2.0492, p=0.047, tcritical=2.0211).
Conclusion: We found beech tree density and habitat disturbance, but not community diversity, to have a significant positive effect on Beech Bark Disease infection rates.
Reduction in Noise Correlation is Associated with Improved Behavioural Performance
Authors: Nath Moushumi , Zhu Xinwen 
Published: July 2022

Background: Visual perception constitutes the dominant method by which we process our environment, yet the neuronal substrates that underlie visual perception in the brain are not well understood. Noise correla- tion, defined as the correlation in non-stimulus evoked activity between neurons, has been shown to impact both encoding and decoding processes of visual stimuli. We wanted to determine whether changes in noise correlation can predict behavioural performance in a coherent motion-detection task.
Methods: Two macaque monkeys (Macaca mulatta) were trained in a coherent motion-detection task, where they learned to fixate on a screen and anticipate the onset of a motion coherence stimulus. During this task, spike activity from pairs of neurons of the middle temporal area (area MT) were recorded and data was analyzed using MATLAB. Specifically, we examined noise correlation as a function of time and success rate in the task.
Results: We found a decrease in the correlation in activity between neurons in area MT prior to the onset of the motion coherence stimulus. This decrease was accompanied by improved behavioural performance in the motion coherence-detection task.
Limitations: The activity in pairs of neurons may not accurately represent overall activity in a population of neurons. In addition, control experiments to better assess the nature of the common input that leads to a reduction in noise correlation were not conducted.
Conclusions: Despite these limitations, we have shown that a reduction in noise correlation prior to stimulus onset is accompanied by improved behavioural performance, suggesting that noise correlation may be a critical parameter that can aid in our understanding of how visual perception occurs in the brain.
Changing Climate Change
Authors: Willard-Stepan Maya , Fong Allie , Sabaa Yehia 
Published: July 2022

It is well established that global warming surpassing 1.5-2°C above pre-industrial levels will cause irreversible damage to our world. The adverse rise in global temperatures is accelerated by anthropogenic activity such as greenhouse gas emissions and environmental degradation. While certain scenarios have been projected to significantly lower global warming rates, most of these developments will require immediate global top-down policy shifts. Several international treaties and agreements have been created to combat climate change. Nonetheless, these remain ineffective at creating meaningful progress and cast doubt on how realizable a positive climate scenario is.
In this review, we analyze how regional policies and actions combat the climate crisis by examining how specific community initiatives impact climate indicators such as reforestation, greenhouse gas emissions reduction, and sustainable agriculture. Our findings conclude that local initiatives have shown more immediate success compared to their global counterparts. Thus, additional locally led climate initiatives is warranted.