bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correspondence in parents' and children's concepts of god: Investigating the role of parental values, religious practices and executive functioning
Authors: Saide Anondah , Richert Rebekah 
Published: May 2022

AbstractThis study examined the extent to which children's concepts of God correspond with their parents' concepts of God. It also examined how parent‐context factors and children's executive functioning relate to parent–child conceptual similarity. Parent–child dyads from varied religious and racial backgrounds participated. Dyads had the greatest conceptual similarity concerning God's mind‐dependent functions. Though correspondence between parents and children was lowest concerning God's body‐dependent functions, dyads were more similar about those functions when parents engaged in more frequent religious practices with their child and thought God was important. Children's concepts of God were unrelated to religious practices, and parent–child conceptual similarity was unrelated to children's age and executive functioning. Simply put, variation among parents' anthropomorphic concepts of God drove variation in parent–child conceptual similarity. Overall, these findings suggest that embodied concepts of God may be most sensitive to cultural input and that socialization practices provide greater insight into parents' anthropomorphic concepts.
Oncogenic LINC00857 recruits TFAP2C to elevate FAT1 expression in gastric cancer
Authors: Zhang Wenqing , Ji Kaiyue , Min Congcong , Zhang Cuiping , Yang Lin , Zhang Qi , Tian Zibin , Zhang Mengyuan , Wang Xinyu , Li Xiaoyu 
Published: May 2022

AbstractFAT atypical cadherin 1 (FAT1) is a mutant gene frequently found in human cancers and mainly accumulates at the plasma membrane of cancer cells. Emerging evidence has implicated FAT1 in the progression of gastric cancer (GC). This study intended to identify a regulatory network related to FAT1 in GC development. Upregulated expression of FAT1 was confirmed in GC tissues, and silencing FAT1 was observed to result in suppression of GC cell oncogenic phenotypes. Mechanistic investigation results demonstrated that FAT1 upregulated AP‐1 expression by phosphorylating c‐JUN and c‐FOS, whereas LINC00857 elevated the expression of FAT1 by recruiting a transcription factor TFAP2C. Functional experiments further suggested that LINC00857 enhanced the malignant biological characteristics of GC cells through TFAP2C‐mediated promotion of FAT1. More importantly, LINC00857 silencing delayed the tumor growth and blocked epithelial–mesenchymal transition in tumor‐bearing mice, which was associated with downregulated expression of TFAP2C/FAT1. To conclude, LINC00857 plays an oncogenic role in GC through regulating the TFAP2C/FAT1/AP‐1 axis. Therefore, this study contributes to extended the understanding of gastric carcinogenesis and LINC00857 may serve as a therapeutic target for GC.
Efficacy of an oral CRTH2 antagonist (AZD1981) in the treatment of chronic rhinosinusitis with nasal polyps in adults: A randomized controlled clinical trial
Authors: Price Caroline P. E. , Guo Amina , Stevens Whitney W. , Cousens Leslie , Vu Thanh‐Huyen T. , Suh Lydia A. , Erickson Kristin A. , Conley David , Grammer Leslie C. , Kern Robert C. , Tan Bruce K. , Kato Atsushi , Schleimer Robert P. , Smith Stephanie S. , Welch Kevin C. , Peters Anju T. 
Published: May 2022

AbstractBackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is a type 2 inflammatory disease of the upper airways. AZD1981 is a selective antagonist of chemoattractant receptor‐homologous molecule expressed on T helper type 2 and other type 2 cells, including innate lymphoid cells type 2, eosinophils, and basophils.ObjectiveTo evaluate the efficacy of AZD1981 in reducing nasal polyp size when added to intranasal corticosteroids in adult patients with CRSwNP.MethodsEighty‐one subjects (18–70 years of age) with CRSwNP were recruited and screened for trial eligibility from allergy and otolaryngology clinics from a single tertiary care site between June 2016 and August 2019. Eligible patients were randomized in a double‐blind fashion to receive either AZD1981 (n = 22) or placebo (n = 21) orally three times a day for 12 weeks, added to intranasal corticosteroids. The primary endpoint was a change in nasal polyp score (NPS) at 12 weeks. Secondary endpoints included improvement in sinus computed tomography using Lund Mackay scoring, symptoms using visual analog scale, quality of life using Sino Nasal Outcome Test‐22, and the Brief Smell Identification Test.ResultsForty‐three patients met the inclusion criteria and were enrolled. At 12 weeks, there was no difference in NPS change in the AZD1981 arm (mean 0, standard error 0.34, n = 15) compared with placebo (mean 0.20, standard error 0.36, n = 17); mean difference −0.20 (95% confidence interval: −1.21, 0.81; p = .69). No significant differences were observed for Lund Mackay score, symptoms, quality of life, or smell test. AZD1981 was well tolerated except for one case of hypersensitivity reaction.ConclusionIn patients with CRSwNP, the addition of AZD1981 to intranasal corticosteroids did not change nasal polyp size, radiographic scores, symptoms, or disease‐specific quality of life.
Care with allergen immunotherapy for allergic respiratory diseases in Germany—Predictors and deficits
Authors: Valbert Frederik , Neusser Silke , Pfaar Oliver , Klimek Ludger , Sperl Annette , Werfel Thomas , Hamelmann Eckard , Riederer Cordula , Wobbe‐Ribinski Stefanie , Hillerich Vivienne , Neumann Anja , Wasem Jürgen , Biermann‐Stallwitz Janine 
Published: May 2022

AbstractBackgroundAllergen immunotherapy (AIT) represents the only possibility of causal therapy for allergic respiratory diseases. Although the prevailing high prevalence of allergic diseases and restrictions in the daily lives of patients, AIT is offered to a suboptimal number of patients in Germany.MethodsInsured patients with documented allergic respiratory disease of one of the largest statutory health insurances in Germany, ‘DAK‐Gesundheit’, were contacted by postal mail and asked to participate in the study. In case of written consent, primary and secondary data of patients were collected and analysed. Patient characteristics, predictors of being offered AIT, predictors of performing AIT and guideline‐compliant care were analysed.Results2505 subjects were included in the VerSITA study. Allergy to tree pollen and native speaking were identified as predictors, which increase the probability of being offered AIT. The probability was significantly decreased by the characteristics allergic rhinitis only, allergic asthma only, age in years, non‐German citizenship, no graduation and lower secondary qualification. Significant positive predictors for an AIT to be actually performed were: Allergy to tree pollen and male sex. Predictors that decrease the likelihood that AIT is performed were: only allergic asthma, current smoker, former smoker, age and non‐German citizenship. Furthermore, it was possible to identify characteristics in which guideline‐compliant patients differed significantly from the rest of the study population.ConclusionsBased on statutory health insurance data and patient survey data, the VerSITA study provides a broad and in‐depth overview of the care situation with regard to AIT in Germany and identifies deficits.
Atrans‐Europeanperspective on how artists can support teachers, parents and carers to engage with young people in the creative arts
Authors: Dobson Tom , Stephenson Lisa 
Published: May 2022

AbstractWhilst the link between young people's well‐being and the creative arts is strengthening, there is a lack of research which focuses on the roles that artists play to help teachers and parents engage young people in the creative arts. This paper explores the benefits of and barriers to artists working in education in six European countries (England, Iceland, Germany, Greece, Italy and Austria). Using the ‘5A's model of creativity’ and a view of professional development taking place within ‘landscapes of practice’, the data were analysed in order to explain how creativity is operationalised in the different contexts. Our study highlights the need for policy at a national and transnational level to value the creative arts in order to help teachers cross boundaries and utilise the full potential of the creative arts in schools. Our study also highlights that further research is needed into how artists shape teaching and curriculum and how schools engage parents in the creative arts in order to build an evidence‐base relating to young people's positive mental health that can affect policy at these levels.
Iron homeostasis in heart transplant recipients randomized to ferric derisomaltose or placebo
Authors: Brautaset Englund Kristine V. , Østby Charlotte M. , Broch Kaspar , Ueland Thor , Aukrust Pål , Gude Einar , Andreassen Arne K. , Gullestad Lars 
Published: May 2022

AbstractIntroductionThe randomized IronIC trial evaluated the effect of intravenous ferric derisomaltose on physical capacity in iron‐deficient, maintenance heart transplant (HTx) recipients. Iron deficiency was defined as in heart failure with high cut‐points for ferritin to compensate for inflammation. However, intravenous iron did not improve physical capacity except in patients with ferritin <30 μg/L. We aimed to explore determinants of iron status in the 102 IronIC participants to better define iron deficiency in the HTx population.MethodsWe assessed key governors of iron homeostasis, such as hepcidin, soluble transferrin receptor (sTfR), and interleukin‐6 (IL‐6). We also measured growth factors and inflammatory markers with relevance for iron metabolism. The results were compared to those of 21 healthy controls.ResultsHepcidin did not differ between HTx recipients and controls, even though markers of inflammation were modestly elevated. However, HTx recipients with ferritin <30 μg/L or sTfR above the reference range had significantly reduced hepcidin levels suggestive of true iron deficiency. In these patients, intravenous iron improved peak oxygen uptake. Hepcidin correlated positively with ferritin and negatively with sTfR.ConclusionHTx recipients with iron deficiency as defined in heart failure do not have elevated hepcidin levels, although inflammatory markers are modestly increased. The high ferritin cut‐offs used in heart failure may not be suitable to define iron deficiency in the HTx population. We suggest that hepcidin and sTfR should be measured to identify patients with true iron deficiency, who might benefit from treatment with intravenous iron.
Functional group‐dependent responses of forest bird communities to invasive predator control and habitat fragmentation
Authors: Morgan Shaun , Binks Nigel A. , Didham Raphael K. , Barnes Andrew D. 
Published: May 2022

AbstractAimMounting global pressure on bird populations from invasive predators and habitat loss has driven a rapid growth in restoration and conservation action around the world, yet the efficacy of such actions is still not well understood. We investigated the relative and interactive effects of invasive predator control and habitat fragmentation on the abundance of native birds and invasive mammalian predators in native forest fragments.LocationWaikato region, New Zealand.MethodsWe sampled invasive mammalian predator and native bird abundances using camera traps and bird counts at 26 sites in 15 forest fragments across New Zealand's Waikato region. Fragment area, shape complexity and surrounding land cover of exotic and native forest were determined in ArcMap. We further created two composite gradients reflecting predator control intensity and temporal distribution of control based on seven quantitative variables recorded in each of the 5 years preceding data collection. Finally, we estimated the relative influence of these drivers on invasive mammals and functional groups of native birds using model averaging.ResultsBoth the intensity and temporal distribution of invasive predator control significantly affected invasive predator abundance. Landscape and fragment structure were often equally important drivers of invasive predator abundances, but responses varied among invasive mammal species. Both invasive predator control intensity and fragment structure were similarly important drivers of native bird abundance, though bird community responses varied markedly between functional groups.Main conclusionsOur findings suggest that spatial extent of invasive predator control and fragment area constrain invasive predator numbers and enhance bird abundance, especially for small insectivorous species, whilst other aspects of habitat fragmentation are less important for invasive mammals but at least as important for native bird communities. Consequently, both drivers should be given strong consideration when undertaking landscape‐scale conservation and restoration of bird communities in human‐altered landscapes threatened by invasive predators.
Bumetanide for neonatal seizures: No light in the pharmacokinetic/dynamic tunnel
Authors: Kaila Kai , Löscher Wolfgang 
Published: May 2022

AbstractIn his editorial, Kevin Staley criticizes our recent work demonstrating the lack of effect of bumetanide in a novel model of neonatal seizures. The main points in our response are that (1) our work is on an asphyxia model, not one on "hypercarbia only"; (2) clinically relevant parenteral doses of bumetanide applied in vivo lead to concentrations in the brain parenchyma that are at least an order of magnitude lower than what would be sufficient to exert any direct effect—even a transient one—on neuronal functions, including neonatal seizures; and (3) moreover, bumetanide's molecular target in the brain is the Na‐K‐2Cl cotransporter NKCC1, which has vital functions in neurons, astrocytes, and oligodendrocytes as well as microglia. This would make it impossible even for highly brain‐permeant NKCC1 blockers to specifically target depolarizing and excitatory actions of γ‐aminobutyric acid in principal neurons of the brain, which is postulated as the rationale of clinical trials on neonatal seizures.
Dysregulated behaviour of hair follicle stem cells triggers alopecia and provides potential therapeutic targets
Authors: Liu Yuanhong , Yang Shengbo , Zeng Yilan , Tang Ziting , Zong Xiule , Li Xuemei , Yang Caifeng , Liu Lulu , Tong Xiaoliang , Zhou Lu , Wang Dan 
Published: May 2022

AbstractDue to a steady increase in the number of individuals suffering from alopecia, this condition has recently received increasing attention. Alopecia can be caused by various pathological, environmental or psychological factors, eventually resulting in abnormalities in hair follicle (HF) structures or HF regeneration disorders, especially dysregulated hair follicle stem cell (HFSC) behaviour. HFSC behaviour includes activation, proliferation and differentiation. Appropriate HFSC behaviour sustains a persistent hair cycle (HC). HFSC behaviour is mainly influenced by HFSC metabolism, ageing and the microenvironment. In this review, we summarize recent findings on how HFSC metabolism, ageing and the microenvironment give rise to hair growth disorders, as well as related genes and signalling pathways. Recent research on the application of stem cell‐based hair tissue engineering and regenerative medicine to treat alopecia is also summarized. Determining how dysregulated HFSC behaviour underlies alopecia would be helpful in identifying potential therapeutic targets.
Glibenclamide promoted functional recovery following sciatic nerve injury in male Wistar rats
Authors: Ferdowsi Sevin , Abdolmaleki Arash , Asadi Asadollah , Zahri Saber 
Published: May 2022

AbstractThe impact of peripheral nerve damage on a patient's quality of life is severe. The most frequent peripheral nerve crush damage is a sciatic nerve injury. Previous research has shown that glibenclamide (GB) has neuroprotective properties in a variety of oxidative stress‐related disorders, including Alzheimer and Parkinson. The goal of this study was to see how GB affected nerve regeneration and improved function of the sciatic nerve in a rat model following a crush injury. We evaluated motor function, sensory recovery, gene expression, and histomorphometry following damage at different time points. Additionally, we assessed atrophy in the gastrocnemius muscle using histology and mass ratio analyses. Our results suggest that 2, 4, 6, and 8 weeks following glibenclamide therapy, promotes the recovery of motor and sensory function in the injured site. Following glibenclamid injection, the mRNA levels of neurotrophic factors (NGF and BDNF) are raised. According to histomorphometry assessment, glibenclamide injection also increased the number of myelinated fibers while decreasing their thickness. These results showed that glibenclamide therapy by decreasing the proinflammatory and oxidant factors may enhance the nerve regeneration. It is clear that more research is needed to confirm these findings.
Phenotypic architecture of sociality and its associated genetic polymorphisms in zebrafish
Authors: Gonçalves Claúdia , Kareklas Kyriacos , Teles Magda C. , Varela Susana A. M. , Costa João , Leite Ricardo B. , Paixão Tiago , Oliveira Rui F. 
Published: May 2022

AbstractSociality relies on motivational and cognitive components that may have evolved independently, or may have been linked by phenotypic correlations driven by a shared selective pressure for increased social competence. Furthermore, these components may be domain‐specific or of general‐domain across social and non‐social contexts. Here, we used zebrafish to test if the motivational and cognitive components of social behavior are phenotypically linked and if they are domain specific or of general domain. The behavioral phenotyping of zebrafish in social and equivalent non‐social tests shows that the motivational (preference) and cognitive (memory) components of sociality: (1) are independent from each other, hence not supporting the occurrence of a sociality syndrome; and (2) are phenotypically linked to non‐social traits, forming two general behavioral modules, suggesting that sociality traits have been co‐opted from general‐domain motivational and cognitive traits. Moreover, the study of the association between single nucleotide polymorphisms (SNPs) and each behavioral module further supports this view, since several SNPs from a list of candidate “social” genes, are statistically associated with the motivational, but not with the cognitive, behavioral module. Together, these results support the occurrence of general‐domain motivational and cognitive behavioral modules in zebrafish, which have been co‐opted for the social domain.
Beyond stakeholder engagement in the coastal zone: Toward a systems integration approach to support just transformation of the blue economy
Authors: Kelly Miriah M. Russo 
Published: May 2022

AbstractTransformation has become a prevailing and desirable concept in blue economy literature. In parallel, researchers have been considering ways to effectively engage stakeholders to support just transformational agendas. Globally, coastal communities are already being affected by the inevitable impacts of climate change and changes to the blue economy. These pressures present complex contexts for coastal zone stakeholder engagement. In this paper, I argue that taking a systems integration approach to interacting with stakeholders is needed to support just transformational change. Assessing stakeholder systems and their relationship to coastal resources is imperative for understanding dynamics that may promote or hinder just transformation. Taking an adaptive management approach to working alongside stakeholders through transitional processes, thus building capacity, is needed to generate momentum toward just transformational change. Lastly, I explain how applications of the subsidiarity principle in integrating stakeholder systems can support a just transformational process and can inform more durable transformational outcomes.
A Review of Low‐Impact Development Factors Affecting Managed Aquifer Recharge
Authors: Job Charles 
Published: May 2022

AbstractLow‐impact development (LID) technology for stormwater control has a number of forms, some of which relate to managed aquifer recharge to provide adequate safe water to communities. Stormwater collected through LID for managed aquifer recharge shifts water quantity and quality effects from surface waters to groundwater. Factors affecting quantity and quality of recharge influence and are influenced by state/local land development policy, state/local groundwater policy, regulation and codes and climate change effects, as well as pretreatment requirements. Groundwater quality effects of untreated stormwater infiltration by LID in a range of hydrogeologic settings are not well understood. Site selection for LID will include hydrogeologic considerations, onsite footprint and construction factors. Cost of the technology has a wide range of typically low‐cost options. Lessons learned include: matching technology to hydrogeologic setting; state/local policy should serve to avoid hydraulic and pollutant effects, particularly high water impacts; representative groundwater monitoring adds safeguard to water supply; and LID systems designs should consider life cycle costing including vulnerable geology, not just low installation cost.
Likelihood of response with subsequent dosing for patients with migraine and initial suboptimal response with eptinezumab: A post hoc analysis of two placebo‐controlled randomized clinical trials
Authors: Schim Jack D. , Anderson Carlton , Brunner Elizabeth , Hirman Joe , Ogbru Annette , Cady Roger , McGill Lora 
Published: May 2022

AbstractObjectiveTo develop a multivariable model assessing factors predicting a second‐dose response to eptinezumab treatment over weeks 13–24 in patients with migraine initially reporting a suboptimal response over weeks 1–12.BackgroundEptinezumab is a monoclonal antibody used for migraine prevention, administered every 12 weeks. In the PROMISE‐1 and PROMISE‐2 studies, the first‐dose response to eptinezumab treatment (≥50% monthly migraine day [MMD] reduction over weeks 1–12) occurred in ~50–60% of patients with episodic (EM) and chronic migraine (CM), respectively.MethodsThis post hoc analysis included patients with suboptimal first‐dose response (<50% MMD reduction over weeks 1–12) with EM and CM, with patient‐reported outcome data at weeks 12 and 24. Eptinezumab 100 and 300 mg doses were pooled.ResultsThe analysis included 416/888 patients (46.8%) from PROMISE‐1 and 479/1072 patients (44.7%) from PROMISE‐2 with suboptimal first‐dose response. The proportion of suboptimal first‐dose responders who were second‐dose responders was 37.0% (71/192; eptinezumab) and 33.9% (42/124; placebo) in PROMISE‐1 and 28.8% (79/274) and 18.5% (38/205) in PROMISE‐2. Significant first‐dose predictors of second‐dose response were percent change in MMDs across weeks 1–12 (PROMISE‐1, odds ratio [OR]: 0.97, 95% confidence interval [CI]: 0.95, 0.98, p = 0.0001; PROMISE‐2, OR: 0.94, CI: 0.92, 0.96, p < 0.0001) and change in 6‐item Headache Impact Test (HIT‐6) total score (PROMISE‐2 only, OR: 0.92; CI: 0.87, 0.98; p = 0.027). In PROMISE‐1, the probability of second‐dose response ranged from 21.7% in patients with first‐dose 0% MMD change to 56.0% in patients with first‐dose 45% MMD reduction. In PROMISE‐2, depending on HIT‐6 total score, probability of second‐dose response ranged from 5.9–12.1% in patients with first‐dose 0% MMD change to 54.2%–72.3% in patients with first‐dose 45.0% MMD reduction.ConclusionIndividuals with migraine not experiencing ≥50% MMD response to their first dose of eptinezumab may benefit from a second dose.