bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is mesenchymal stem cell effective for allergic rhinitis? A protocol for a systematic review and meta-analysis
Authors: Yan Le , Zheng Hanxue , Zhang Huiping , Dai Lintong , Zhang Qinxiu 
Published: October 2022

IntroductionAllergic rhinitis (AR) is a kind of widespread but unrecognised inflammatory disorder of nasal mucosa, characterised by itching, sneezing, runny nose and nasal congestion. The efficacy of mesenchymal stem cells (MSCs) in the treatment of AR remains controversial. This protocol describes a systematic review and meta-analysis approach to assess the efficacy and safety of MSCs in the treatment of AR.Methods and analysisEight databases (PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, VIP and Wanfang) will be searched from the database inception to 1 December 2023. All randomised controlled trials related to MSCs for AR will be included. The primary outcomes will be therapeutic effect, serum IgE index and Visual Analogue Scale score for nasal symptoms. Risk of bias will be assessed using the Cochrane Collaboration’s tool for assessing risk of bias. Article selection, data extraction and risk of bias assessment will be performed in duplicate by two independent reviewers.Ethics and disseminationEthics approval is not required because individual patient data are not included. This protocol was registered in the international Prospective Register of Systematic Reviews on 22 January 2022. The systematic review and meta-analysis will be submitted for publication in a peer-reviewed journal. The findings will also be disseminated through conference presentations.PROSPERO registration numberCRD42022303146.
Health problems in national team cross-country skiers over a competitive season: a 17-week prospective cohort study
Authors: Karlsson Øyvind , Danemar Magnus , Laaksonen Marko S , McGawley Kerry 
Published: October 2022

ObjectiveFew long-term prospective studies have investigated health problems in elite competitive cross-country (XC) skiers. Hence, our objective was to compare the prevalence of health problems in national team XC skiers over a competitive season.MethodsForty national team XC skiers participated in this prospective, observational study. Two groups were characterised according to performance level: senior (n=18, ~26 years old, 9 women) and development (n=22, ~21 years old, 9 women). The skiers reported all and substantial injuries and illnesses weekly for 17 consecutive weeks throughout the 2019/2020 competitive season using the Oslo Sports Trauma Research Center Questionnaire on Health Problems.ResultsThe average weekly prevalence of all and substantial health problems was 19% (95% CI: 16% to 22%) and 12% (95% CI: 9% to 15%), respectively, and was similar between senior and development level skiers (p>0.05). The injury prevalence was higher in senior versus development level skiers (12%, 95% CI: 9% to 15% vs 5%, 95% CI: 3% to 7%; p<0.001), while illnesses were less common (8%, 95% CI: 3% to 13% vs 13%, 95% CI: 9% to 17%, respectively; p=0.031). Illnesses accounted for 72% of all problems. The prevalence of all health problems was higher in female than in male skiers (23%, 95% CI: 19% to 27% vs 15%, 95% CI: 11% to 19%; p<0.003).ConclusionsHealth problems, especially illnesses, were relatively common, with approximately one in five skiers (19%) reporting at least one problem in any given week. Both performance level and sex influenced the prevalence of different types of health problems.
Coronary perforation incidence, outcomes and temporal trends (COPIT): a systematic review and meta-analysis
Authors: Mikhail Philopatir , Howden Nicklas , Monjur Mohammad , Jeyaprakash Prajith , Said Christian , Bland Adam , Collison Damien , McCartney Peter , Adamson Carly , Morrow Andrew , Carrick David , McEntegart Margaret , Ford Thomas J 
Published: October 2022

Coronary perforation is a potentially life-threatening complication of percutaneous coronary intervention (PCI). We studied incidence, outcomes and temporal trends following PCI-related coronary artery perforation (CAP).MethodsProspective systematic review and meta-analysis including meta-regression using MEDLINE and EMBASE to November 2020. We included ‘all-comer’ PCI cohorts including large PCI registries and randomised controlled trials and excluding registries or trials limited to PCI in high-risk populations such as chronic total occlusion PCI or cohorts treated only with atheroablative devices. Regression analysis and corresponding correlation coefficients were performed comparing perforation incidence, mortality rate, tamponade rate and the rate of Ellis III perforations against the midpoint (year) of data collection to determine if a significant temporal relationship was present.Results3997 studies were screened for inclusion. 67 studies met eligibility criteria with a total of 5 568 191 PCIs included over a 38-year period (1982–2020). The overall pooled incidence of perforation was 0.39% (95% CI 0.34% to 0.45%) and remained similar throughout the study period. Around 1 in 5 coronary perforations led to tamponade (21.1%). Ellis III perforations are increasing in frequency and account for 43% of all perforations. Perforation mortality has trended lower over the years (7.5%; 95% CI 6.7% to 8.4%). Perforation risk factors derived using meta-regression were female sex, hypertension, chronic kidney disease and previous coronary bypass grafting. Coronary perforation was most frequently caused by distal wire exit (37%) followed by balloon dilation catheters (28%). Covered stents were used to treat 25% of perforations, with emergency cardiac surgery needed in 17%.ConclusionCoronary perforation complicates approximately 1 in 250 PCIs. Ellis III perforations are increasing in incidence although it is unclear whether this is due to reporting bias. Despite this, the overall perforation mortality rate (7.5%) has trended lower in recent years. Limitations of our findings include bias that may be introduced through analysis of multidesign studies and registries without pre-specified standardised perforation reporting CMore research into coronary perforation management including the optimal use of covered stents seems warranted.PROSPERO registration numberCRD42020207881.
Thermal tolerance in cutthroat trout of the southern Rocky Mountains
Authors: Rogers Kevin B. , Sucher Brendon J. , Hodge Brian W. , Myrick Christopher A. 
Published: October 2022

With temperatures expected to rise across the southern Rocky Mountains, the ability of native fishes to tolerate stream warming has become a critical concern for those tasked with preserving coldwater species. We used common garden experiments to evaluate the thermal tolerance of cutthroat trout ( Oncorhynchus clarkii) fry from five populations important to managers representing three sub-species. Critical thermal maxima (CTMs) were evaluated through traditional exposure trials, while optimal growth and ultimate upper incipient lethal temperatures (UUILTs) were examined over the course of 21-day trials at six static temperature treatments. Whereas CTMs differed among populations (mean = 27.91 °C, SD = 0.35 °C), UUILTs did not (mean = 24.40 °C, SD = 0.04 °C). Comparison of cubic temperature-growth functions to the traditional quadratic functions showed that adding a third-order term for temperature can improve model fit, and revealed substantial differences in optimal growth temperatures (15.4–18.3 °C). Knowledge of these thermal tolerance thresholds will help to predict the consequences of a warming climate, identify suitable habitats for repatriation, and inform water quality temperature standards established to protect these fish into the future.
DHOST gravity in ultra-diffuse galaxies – part I: the case of NGC1052-DF2
Authors: Laudato Enrico , Salzano Vincenzo 
Published: October 2022

AbstractThe Ultra-Diffuse galaxy NGC1052-DF2 has recently been revealed to be “extremely deficient” in dark matter, if not lacking it at all. This claim has raised many questions regarding the relationship between baryons and dark matter in Ultra-Diffuse galaxies. But there seems to be a quite unanimous belief that, if such very low dark matter content is confirmed and extended to other similar galactic objects, it might be a deathblow to theories which modify and extend General Relativity. Deficient dark matter galaxies thus represent a fertile ground to test both standard dark matter and modified gravity theories. In this work, we consider a specific Degenerate Higher-Order Scalar Tensor model to study the internal kinematics of NGC1052-DF2. Due to the partial breaking of the corresponding screening mechanism, this model can possibly have large cosmological scale effects influencing the dynamics of smaller structures like galaxies. We consider two scenarios: one in which the model only describes dark energy; and one in which it additionally entirely substitutes dark matter. We find that the best model to explain data is General Relativity with only stellar contribution. But while in the former scenario General Relativity is still statistically favoured, in the latter one the alternative model is as much successful and effective as General Relativity in matching observations. Thus, we can conclude that even objects like NGC1052-DF2 are not in contrast, and are not obstacles, to the study and the definition of a reliable alternative to General Relativity.
The Hong–Ou–Mandel experiment: from photon indistinguishability to continuous-variable quantum computing
Authors: Fabre N. , Amanti M. , Baboux F. , Keller A. , Ducci S. , Milman P. 
Published: October 2022

Abstract
We extensively discuss the Hong–Ou–Mandel experiment by taking an original phase-space-based perspective. For this, we analyze time and frequency variables as quantum continuous variables in perfect analogy with position and momentum of massive particles or with the electromagnetic field’s quadratures. We discuss how this experiment can be used to directly measure the time-frequency Wigner function and implement logical gates in these variables. We also briefly discuss the quantum/classical aspects of this experiment providing a general expression for intensity correlations that make explicit the differences between a classical Hong–Ou–Mandel-like dip and a quantum one. Throughout the manuscript, we will often focus and refer to a particular system based on AlGaAs waveguides emitting photon pairs via spontaneous parametric down conversion, but our results can be extended to other analogous experimental systems and to various degrees of freedom.

Graphical Abstract
The Hong–Ou–Mandel experiment is a landmark in quantum optics, showing the bunching of indistinguishable bunch. In the present contribution, we give another perspective to this experiment based on a phase space representation of the continuous degrees of freedom of the single photons sent into the input arms of such interferometer. We show that the coincidence detection in the output ports of an Hong– Ou–Mandel interferometer is a direct measurement of the Wigner function of the produced photons in a given region of space, and we discuss how continuous degrees of freedom of single photons can be used in continuous variables quantum protocols, as quantum error correction and metrology. Our results open the perspective of broadening even more the applications of single photon-based quantum information-related protocols.
Fault detection in an interconnected power system using optimal number of phasor measurement unit
Authors: Krishnan Kiruthika , Iyengar Srivani 
Published: October 2022

<p>Fault identification in a power system is crucial. In recent days, there have been multiple microgrids connected to the power system. And if many buses are connected, then there is a need for an increase in the phasor measurement unit. By using an optimization technique, the number of phasor measurement unit PMUs can be reduced by placing them optimally. In this paper, the fault detection algorithm is implemented using a reduced number of PMUs with the help of the particle swarm optimization (PSO) algorithm. The optimal locations of PMUs are identified using the PSO algorithm. Here, the reduction in the count of PMUs and the PMUs are designed in MATLAB as a model. This is done using the Simulink and dashboard block sets. The IEEE 9 and IEEE 30 test systems are used here for the analysis and tests. The IEEE 9 bus system is constructed in simulation and then the PMU is constructed using the data taken from the phasor measurement blocks. This data is used in the dashboard block set to represent the PMU-based fault detection system.</p>
Interactive Moiré Patterns Reflecting on the Traditional Nanjing Baiju
Authors: Yang Ye , Chen Guangxi , Li Mengqi , Zhang Kang 
Published: October 2022

AbstractThis article presents a human-machine design approach to the artistic and metaphorical representation of the traditional weaving scenes featured on Yunjin brocade as interactive moiré patterns accompanied by Nanjing Baiju performance. After extracting the basic elements of the eye-shaped moiré patterns, the authors systematically recomposed them to mimic the weaving process. They then wrote an algorithm to generate moiré patterns that respond dynamically to the unique sounds weavers make while weaving, symbolizing the gazes and eye contacts among the weavers. This became an interactive sonic installation, Sweating Weaving Room, which represents the rhythmic machine sounds, the Nanjing Baiju, and the hard labor and harmonious work hidden behind the glamorous brocade.
Entangled Realities: Emerging Performances of Relating Humans, Sonatars, and Spaces
Authors: Pirchner Andreas 
Published: October 2022

AbstractThis article investigates music performances with audiovisual components in extended reality setups that are not score based, but composed, emerging from a discursive process of interrelating human performers and computational counterparts such as virtual performance partners, virtual instruments, and potentials related to particular spaces. Rooted in notions of earlier avant-garde music and digital games, the performances are understood to emerge from a bottom-up process of relating human-technological agencies. A dichotomy of preexistent physical and virtual realities that would be extended or mixed is consequently replaced by a notion of entangled realities, as the artistic reality of the artwork emerges with the performance.
PlantConnect
Authors: Castellanos Carlos 
Published: October 2022

Abstract
This paper describes PlantConnect, a real-time interactive system that explores human-plant interaction via the human act of breathing, the bioelectrical and photosynthetic activity of plants, and computational intelligence to bring the two together. Part of larger investigations into alternative models for the creation of shared experiences and understanding with the natural world, the work is presented as a concrete implementation of a possible model based upon reciprocal interplay and information flows between human and nonhuman worlds.
Topological Vision: The Artistic Thinking of Shigeru Onishi
Authors: Herrie Maja Bak 
Published: October 2022

Abstract
This article examines the work of the Japanese mathematician and photographer Shigeru Onishi (1928–1994) and his topologically inspired photographic experiments. It considers how his painterly play with emulsion and coloration is a visual exploration of questions of process and continuous transformation and how these experiments can be understood in relation to more general discussions of mathematical and artistic “ways of knowing “ Building on ideas introduced by the French philosopher Maurice Merleau-Ponty in his work on late Paul Cézanne, the article introduces the concept of topological vision to describe and account for a particular way of seeing that considers the continual coming-into-being of a photographic motif.
Typology of Emotion Assemblages in Art and Science
Authors: Nold Christian 
Published: October 2022

AbstractThis article analyzes how artists and scientists use emotion as a methodological tool to study participants and cocreate projects. It uses a science and technology studies approach to identify a typology of five emotion assemblages and the material, social, and cultural components that make them operate. These assemblages include or eliminate cultural and environmental context, the role of participants, and artist/researcher reflexivity The paper argues that there is an imperative for artists, designers, and researchers to make deliberate choices as to who or what to include and exclude when working with emotion.
Validation of ratings on the six-item Positive and Negative Syndrome Scale obtained via the Simplified Negative and Positive Symptoms Interview among outpatients with schizophrenia
Authors: Nielsen Cecilie Marie , Kølbæk Pernille , Dines David , Pedersen Martin Locht , Danielsen Andreas Aalkjær , Holmgård Camilla , Wissing Sanne , Esbøl Anne-Mette , Fuglsang Nina Friis Bak , Nguyen Tuan Dang , Mors Ole , Opler Mark , Correll Christoph U , Østergaard Søren Dinesen 
Published: October 2022

Background: The six-item Positive and Negative Syndrome Scale (PANSS-6) is a measure of the severity of core symptoms of schizophrenia, which can be administered via the brief Simplified Negative and Positive Symptoms Interview (SNAPSI). A recent study has confirmed the validity of PANSS-6 ratings as derived by SNAPSI (PANSS-6SNAPSI) among inpatients with schizophrenia. Aims: We aimed to test the validity of PANSS-6SNAPSI among outpatients with schizophrenia using PANSS-6 ratings extracted from the 30-item PANSS-30 as derived by the Structured Clinical Interview for the Positive and Negative Syndrome Scale (PANSS-6SCI-PANSS) as a gold standard reference. Methods: PANSS-6SNAPSI and PANSS-6SCI-PANSS ratings were obtained at two time points by independent raters with established inter-rater reliability. Agreement between PANSS-6SNAPSI and PANSS-6SCI-PANSS ratings was estimated via intra-class coefficients (ICCs) and responsiveness over time was quantified using Spearman’s rank correlation coefficients. Post hoc “leave-one-out” analyses were carried out, in which each rater in turn was excluded from the ICC calculations. Results: Seventy-three outpatients with schizophrenia participated in the study (mean age: 38.3 years; 56% males). The ICC for PANSS-6SNAPSI versus PANSS-6SCI-PANSS was 0.67 [95%CI = 0.56–0.76] and the Spearman’s rank correlation coefficient for responsiveness was 0.40 ( p = 0.004). When data from a specific outlying rater were excluded, the ICC for PANSS-6SNAPSI versus PANSS-6SCI-PANSS was 0.75 [95% CI = 0.63–0.83] and the Spearman’s rank correlation coefficient for responsiveness was 0.55 ( p = 0.018). Conclusions: We found PANSS-6SNAPSI ratings to have acceptable clinical validity, suggesting that PANSS-6SNAPSI can be used for both inpatients and outpatients with schizophrenia.
Phosphodiesterase inhibitor, Vinpocetine, guards against doxorubicin induced cardiotoxicity via modulation of HIF/VEGF and cGMP/cAMP/SIRT signaling pathways
Authors: Refaie Marwa M.M. , El-Hussieny Maram , Abdel-Hakeem Elshymaa A. , Fawzy Michael A , Mahmoud Abd El Rahman Eman Shaaban , Shehata Sayed 
Published: October 2022

Purpose: Doxorubicin (DOX) is a widely used chemotherapeutic agent complicated with cardiotoxic adverse effects. Up till now, there are no researches discussing the role of vinpocetine (VIN) in DOX cardiotoxicity. Thus, the aim of our work was to study this effect and explore the different involved mechanisms. Methods: 50 male Wistar albino rats were subjected to DOX toxicity via administration of single i.p. Dose (15 mg/kg) on the 4th day with or without co-administration of VIN (10, 20, 30 mg/kg/day) orally for 5 days. Results: Our data revealed that VIN succeeded in protecting the heart against DOX induced damage as manifested by significant decrease of cardiac enzymes, hypoxia inducible factor alpha (HIF-1α), vascular endothelial growth factor-A (VEGF-A), tissue malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α) and caspase3 levels. Furthermore, VIN given group showed marked improvement of the histopathological changes of cardiac injury, total antioxidant capacity (TAC), elevation of reduced glutathione (GSH), cyclic guanosine monophosphate (cGMP), cyclic adenosine monophosphate (cAMP) and sirtuin-1 (SIRT-1). Conclusion: We concluded that VIN could ameliorate DOX induced cardiac damage and this effect may be attributed to modulation of HIF/VEGF signaling pathway, up-regulation of cGMP/cAMP/SIRT pathway, inhibition of phosphodiesterase enzyme, besides its anti-apoptotic, anti-inflammatory, and anti-oxidant properties.
An International Consensus on Actions to Improve Lung Cancer Survival: A Modified Delphi Method Among Clinical Experts in the International Cancer Benchmarking Partnership
Authors: Lynch Charlotte , Harrison Samantha , Butler John , Baldwin David R. , Dawkins Paul , van der Horst Joris , Jakobsen Erik , McAleese Jonathan , McWilliams Annette , Redmond Karen , Swaminath Anand , Finley Christian J. 
Published: October 2022

Background Research from the International Cancer Benchmarking Partnership (ICBP) demonstrates that international variation in lung cancer survival persists, particularly within early stage disease. There is a lack of international consensus on the critical contributing components to variation in lung cancer outcomes and the steps needed to optimise lung cancer services. These are needed to improve the quality of options for and equitable access to treatment, and ultimately improve survival. Methods Semi-structured interviews were conducted with 9 key informants from ICBP countries. An international clinical network representing 6 ICBP countries (Australia, Canada, Denmark, England, Ireland, New Zealand, Northern Ireland, Scotland & Wales) was established to share local clinical insights and examples of best practice. Using a modified Delphi consensus model, network members suggested and rated recommendations to optimise the management of lung cancer. Calls to Action were developed via Delphi voting as the most crucial recommendations, with Good Practice Points included to support their implementation. Results Five Calls to Action and thirteen Good Practice Points applicable to high income, comparable countries were developed and achieved 100% consensus. Calls to Action include (1) Implement cost-effective, clinically efficacious, and equitable lung cancer screening initiatives; (2) Ensure diagnosis of lung cancer within 30 days of referral; (3) Develop Thoracic Centres of Excellence; (4) Undertake an international audit of lung cancer care; and (5) Recognise improvements in lung cancer care and outcomes as a priority in cancer policy. Conclusion The recommendations presented are the voice of an expert international lung cancer clinical network, and signpost key considerations for policymakers in countries within the ICBP but also in other comparable high-income countries. These define a roadmap to help align and focus efforts in improving outcomes and management of lung cancer patients globally.