bluuebunny/crossref_metadata_2025_split huggingface dataset:
Absence of Effect of Emicizumab on D-Dimer Concentrations in Adult Patients with Severe Hemophilia A
Authors: Iarossi Michael , Lambert Catherine , Hermans Cedric 
Published: December 2022

Background The D-dimer (DD) assay is an essential biological test for the diagnosis and monitoring of thrombotic conditions. DD testing is usually not performed as part of the routine laboratory management of patients with hemophilia (PWH). There is an increasing concern about the risk of thrombotic complications in PWH, which is likely related to age, cardiovascular risk factors, invasive thrombogenic procedures, over-correction of Factor VIII (FVIII) or FIX, or administration of new therapeutic agents mimicking FVIII or rebalancing coagulation. Objective This retrospective study sought to assess the basal DD levels in PWH treated prophylactically with FVIII, and to evaluate potential changes after switching to emicizumab. Method Patients over 18 years of age treated with emicizumab within a single center over the period 2017-2022 were included in the study. Result DD levels were measured in 40 adult PWH (37 severe/ three moderate / two with FVIII inhibitor) with a median age of 46 years (range: 19-82; Q1-Q3: 30,25-56,5), before and at least 3 months after emicizumab initiation. No significant changes were revealed, with DD median values of 257 ng/mL (range: 250-2876; Q1-Q3: 250-493,5) before and 250 ng/mL (range: 50-6205; Q1-Q3: 250-380,25) after the switch (p  =  0.9). Conclusion Most adult PWH on prophylaxis using FVIII display DD levels within the normal range, which remain unchanged after switching to emicizumab. In view of these reassuring results, monitoring of DDs at the start of emicizumab treatment does not appear necessary but could be considered when combined with other bypassing agents or high dose FVIII.
Behavioral Outcomes of Children With In-Utero Opioid Exposure Age 2-7 and Parenting Self-Efficacy
Authors: Arter Sara , Kiel Elizabeth , McAllister Jennifer , Hay M. Cameron 
Published: December 2022

Background: The relationship between behavior difficulties and parenting self-efficacy in children with in-utero opioid exposure (IOE) remains a significant gap that needs to be addressed for providers to better understand the mental health trajectories of children with IOE and help these families. Aims: In this study, caregivers’ perception of their child’s behavior and potential relationships between parenting self-efficacy, child temperament, and behavior difficulties were investigated. Methods: A descriptive survey design with a convenience sample of 143 caregivers of 2- to 7-year-old children with IOE who had follow-up visits in a Neonatal Abstinence Syndrome (NAS) clinic was used for this study. Data were collected using a survey of demographics, the Children’s Behavior Questionnaire, the Strengths and Difficulties Questionnaire, and the Parenting Sense of Competence Scale. Results: The overall sample scored in the average range of behavior difficulties, but a subgroup of children with very high difficulties was identified who exhibited a negative temperament, and caregivers reported a lower sense of parenting competence. There were no differences between groups on demographic variables. Conclusions: High negative affect and low effortful control are predictive of later internalizing and externalizing problems, as well as broader problems in self-regulation, school readiness, and socioemotional competence. Thus, although a large percentage of children treated for NAS appear to be functioning at the same level as their peers, a subset of children appears to be at higher risk. Child behavior as well as caregiver self-efficacy should be assessed during all provider encounters.
Long term outcomes of ‘Christmas Tree’ banding for haemodialysis access induced distal ischemia: A 13-year experience
Authors: Ravindhran Bharadhwaj , Totty Joshua P , Sidapra Misha , Lathan Ross , Carradice Daniel , Chetter Ian C , Smith George E 
Published: December 2022

Background: The reduction in distal arterial flow following arteriovenous fistula (AVF) creation can cause a perfusion deficit known as haemodialysis access induced distal ischemia (HAIDI). Various techniques have been advocated to treat this difficult problem with varying success. We present the long-term outcomes following a novel banding technique. Methods: 46 patients in this cohort from 2008 to 2021 underwent a novel banding procedure using a Dacron™ patch shaped with one slit-end and saw-tooth edges (resulting in a ‘Christmas-tree’ pattern) to provide a ratchet mechanism to progressively constrict the fistula outflow. Real-time finger perfusion pressure monitoring allowed an accurate reduction in AVF flow whilst increasing distal arterial perfusion pressure. Baseline characteristic were recorded and Kaplan-Meier survival curves were obtained to calculate the post-intervention primary, assisted primary and secondary patency. Results: 29 patients presented with rest pain and 11 presented with tissue loss due to distal ischemia. The post-intervention primary access patency was 100%, 98%, 78% and 61% at 30, 60 and 180 days and 1 year respectively. Complete resolution of symptoms was achieved in 74% ( n = 34) of patients and a partial response needing no further intervention was achieved in 11% ( n = 5) of patients. A Youden index calculation suggested that digital pressures of 41 mm Hg or lower in an open AVF were highly sensitive for symptomatic hand ischemia whereas pressures greater than 65 mm Hg ruled out distal ischemia. Conclusion: ‘Christmas-tree’ banding with on table finger systolic pressures is not only an efficacious and durable method for treating HAIDI but also preserves fistula patency.
Locked down or locked out? Trends in psychiatric emergency services utilization during the COVID-19 pandemic
Authors: Duncan Alison , Herrera Carolina-Nicole , Okobi Margaret , Nandi Shurobhi , Oblath Rachel 
Published: December 2022

Objective To estimate changes in Boston Emergency Services Team (BEST) psychiatric emergency services (PES) encounter volume (total and by care team) and inpatient disposition during the first 8 months of the COVID-19 pandemic. Methods Data on 30,657 PES encounters was extracted from the four-county, BEST reporting system. The study period consisted of the first 34 weeks of 2019 and 2020. This period corresponded to the first five stages of Massachusetts’s COVID-19 public health restrictions: pre-lockdown, lockdown, Phase I, II and III reopenings. Descriptive and regression analyses were performed to estimate changes in encounter volume by care team and disposition. Results Compared to the same period in 2019, covariate-adjusted, weekly PES encounters decreased by 39% (β = −0.40, 95% Confidence Interval (CI) = [−0.51, −0.28], p < 0.00) during the lockdown. PES volume remained significantly lower during Phase I reopening compared to the previous year but returned to 2019 levels during Phase II. The covariate-adjusted proportion of weekly encounters that led to inpatient admission significantly increased by 16% (CI = [0.11, 0.21], p < 0.00) for mobile crisis teams (MCTs) and significantly declined by 13% (CI = [−0.19, −0.07], p < 0.00) for BEST-designated emergency departments during the lockdown period compared to the prior year. Conclusions The overall drop in PES utilization and the rise in inpatient admissions for MCT encounters suggests that during the early phases of the pandemic, patients delayed psychiatric care until they had a psychiatric crisis. Public health messaging about the lockdowns and absent equivalent messaging about the availability of telehealth services may have made patients more reluctant to seek psychiatric care.
Inhibitory Control Training Improves Attention Deficit-Hyperactivity Disorder Symptoms and Externalizing Behavior
Authors: Nejati Vahid , Fallah Fatemeh , Raskin Sarah 
Published: December 2022

Background Based on dysexecutive function theory of Attention deficit-hyperactivity disorder (ADHD), inhibitory control plays a crucial role in ADHD symptoms and respective behavioral problems. Methods In the present study, 30 preschoolers with ADHD were recruited in a random clinical trial design in two control and intervention groups. The Flanker and Go/No-Go tasks, Swanson, Nolan, and Pelham Rating Scale, and Child Behavior Checklist were used for assessment at baseline, after the intervention, and 1-month follow-up sessions. The program for attentive rehabilitation of inhibition and selective attention (PARISA) was used for intervention in 10–12 sessions. Results Findings showed an improvement in prepotent inhibition and interference control in the intervention group. Furthermore, the hyperactivity/impulsivity symptoms were ameliorated, and the externalizing behavioral problems were improved after the intervention. Conclusion Inhibitory control in preschoolers with ADHD is trainable, and the training gain could be transferred to ADHD symptoms and externalizing behavior.
A natural experiment: Assessment of Danish high-school students’ alcohol drinking patterns from 2014 and 2019 after the introduction of a common alcohol policy
Authors: Pisinger Veronica S. C. , Hoffmann Sofie Have , Krølner Rikke , Tolstrup Janne 
Published: December 2022

Aim: In this study, using national survey data from 2014 and 2019, we tested the hypothesis that students at schools who introduced a common alcohol policy in 2017 drank less than students at schools without a common policy. Methods: We used survey data from 41 high schools that participated in the Danish National Youth Study in 2014 and 2019. We perceived the introduction of a common high-school alcohol policy in 2017 among local groups of high schools as a natural experiment and assessed it using difference-in-difference analyses. We assessed drinking patterns from 2014 and 2019 among students at schools with and without a common alcohol policy combined and stratified by sex in negative binominal regression and logistic regression models. Drinking patterns were measured as average weekly alcohol use, average alcohol intake at last school party, proportion of non-drinkers and frequent binge drinkers. Results: Drinking patterns were similar among students in schools with and without a common alcohol policy. For example, among students at schools with a common alcohol policy, the average alcohol intake at the last school party among drinkers was 8.7 units in 2014 and 8.5 units in 2019, whereas average alcohol intake among students at schools without a common alcohol policy was 8.8 units in 2014 and 8.9 units in 2019 ( p=0.413). Conclusions: No statistically significant effects were observed following the introduction of a common alcohol policy on students’ drinking patterns, and alcohol consumption among high-school students was stable and remained high in 2014 and in 2019.
Emodin alleviates arthritis pain through reducing spinal inflammation and oxidative stress
Authors: Cheng Ding-Wen , Yue Yuan-Fen , Chen Chun-Xi , Hu Yin-Di , Tang Qiong , Xie Min , Liu Ling , Li Dai , Zhu Hai-Li , Cheng Meng-Lin 
Published: December 2022

Chronic pain is the predominant problem for rheumatoid arthritis patients, and negatively affects quality of life. Arthritis pain management remains largely inadequate, and developing new treatment strategies are urgently needed. Spinal inflammation and oxidative stress contribute to arthritis pain and represent ideal targets for the treatment of arthritis pain. In the present study, collagen-induced arthritis (CIA) mouse model was established by intradermally injection of type II collagen (CII) in complete Freund’s adjuvant (CFA) solution, and exhibited as paw and ankle swelling, pain hypersensitivity and motor disability. In spinal cord, CIA inducement triggered spinal inflammatory reaction presenting with inflammatory cells infiltration, increased Interleukin-1β (IL-1β) expression, and up-regulated NOD-like receptor thermal protein domain associated protein 3 (NLRP3) and cleaved caspase-1 levels, elevated spinal oxidative level presenting as decreased nuclear factor E2-related factor 2 (Nrf2) expression and Superoxide dismutase (SOD) activity. To explore potential therapeutic options for arthritis pain, emodin was intraperitoneally injected for 3 days on CIA mice. Emodin treatment statistically elevated mechanical pain sensitivity, suppressed spontaneous pain, recovered motor coordination, decreased spinal inflammation score and IL-1β expression, increased spinal Nrf2 expression and SOD activity. Further, AutoDock data showed that emodin bind to Adenosine 5‘-monophosphate (AMP)-activated protein kinase (AMPK) through two electrovalent bonds. And emodin treatment increased the phosphorylated AMPK at threonine 172. In summary, emodin treatment activates AMPK, suppresses NLRP3 inflammasome response, elevates antioxidant response, inhibits spinal inflammatory reaction and alleviates arthritis pain.
Radar Indications of Altered Foraging Behavior during the February 2021 Severe North American Cold Wave
Authors: Van Den Broeke Matthew S 
Published: December 2022

Total radar cross-section of birds was quantified in observations of four large bird assemblages with daily sunrise foraging flights for January and February 2021, including the severe February 2021 cold wave. Reduced foraging behavior during the cold wave was expected as birds reduced energy expenditure during the extreme cold. While this was observed with two assemblages in Oklahoma where the cold was most severe, a site in central Texas showed the opposite response, indicating increased foraging to meet increased energy demands. Foraging behavior was influenced by temperature and windspeed, but the direction of this influence differed across sites. This difference seemed partially driven by cold wave severity at individual sites, and may have also been influenced by differing species composition. At the site where waterbirds were the primary contributors, these larger and more cold-tolerant species showed less of a wind/temperature dependence.
Identifying and ranking the attributes of hospitals readiness to apply bring your own device: An explanatory sequential mixed study
Authors: Jahanbakhsh Maryam , Amini-Rarani Mostafa , Tahmasebian Shahram , Shahbazi Masoumeh 
Published: December 2022

Objective The Bring Your Own Device (BYOD) approach has promoted the usage of personal mobile devices for organizational and carrier purposes. Applying a BYOD approach might provide various challenges for healthcare organizations. This study endeavored to identify the attributes of hospitals readiness in applying BYOD and to rank these attributes in order to develop appropriate policies for dealing with challenges. Materials and methods This study is an explanatory sequential mixed method design that was carried out in two qualitative and quantitative phases for identifying the BYOD attributes and ranking them, respectively. Semi-structured interviews with 15 experts in the BYOD field were performed through in the qualitative phase. Purposive and snowball sampling approaches were used to choose experts. Thematic analysis was used to analyze qualitative data. The identified attributes were ranked in a quantitative phase by asking 10 experts using fuzzy hierarchical analysis. Results Six main themes and 23 subthemes were identified. The findings of hierarchical analysis showed that ethical considerations, management principles, human resources, legislation considerations, cost, and technical infrastructure as the six main themes, respectively, have priority in hospitals readiness for BYOD. Conclusion Addressing the highlighted priorities, from ethical considerations to technical infrastructure, in the formulation and implementation of formal programs and policies by health managers and authorities will prepare hospitals for the use of BYOD while decreasing the challenges associated with it.
Learning From the United States?: Policy Transfer and the Development of Chinese Higher Education Since 1978
Authors: Shen (沈文钦) Wenqin 
Published: December 2022

Purpose The paper tries to analyze the impact of the American higher education model on China's higher education since the reform and opening-up, enriching the research on policy learning in comparative education by adding a Sino-U.S. case. Design/Approach/Methods This study focuses on three cases of policy learning: undergraduate education reform, the transformation of polytechnic universities into comprehensive ones, and the introduction of the tenure-track system, using academic archives, oral interviews, and policy texts. Findings This study identifies several characteristics of policy learning. First, while the influence of the United States remains dominant, other countries such as Germany, the United Kingdom, and France have also become learning targets. Second, policy learning from the United States reflects the characteristics of selective adoption, suggesting that the foreign model is partially copied and reinterpreted in the Chinese context. Originality/Value Policy transfer is a classic theme of comparative education research. Although the Western model—and the U.S. model in particular—has had a profound impact on China's higher education reform, research on the impact of the U.S. model since 1978 is limited. This study addresses this gap.
A Newly Identified Complication of Patellofemoral Arthroplasty: Case Report and Literature Review
Authors: Solarino Giuseppe , Maccagnano Giuseppe , Vicenti Giovanni , Buono Claudio , Simone Filippo , Ottaviani Guglielmo , Zavattini Giacomo , Zaccari Domenico , Carrozzo Massimiliano , Spinarelli Antonio , Bizzoca Davide , Moretti Biagio 
Published: December 2022

Background Patellofemoral arthroplasty (PFA) is a surgical option for patients older than 40 years old who are affected by patellofemoral osteoarthritis. Regarding the complications of PFAs, few studies have investigated periprosthetic fractures. The purpose of this literature review was to highlight a previously overlooked complication of primary prosthetic surgery of the patellofemoral joint. Methods Three literature databases were searched for studies published between 2000 to 2020 using relevant keywords. A total of 4,942 articles were originally identified. After excluding duplicates and analysing the titles and abstracts, 20 studies were considered. From these, data regarding the number of cases, clinical outcomes and complications were extracted. Results Among the 20 selected articles, only one described periprosthetic fractures as a complication of PFAs. Herein, we also report an illustrative case of an unknown fracture complication. No cases in the literature were found that described the type of complications experienced by our patient during the postoperative period. Conclusions This review confirms the lack of data about clinical outcomes and fracture complications of PFAs. In primary prosthetic surgery of the patellofemoral joint, patient selection and close consideration of demographic factors (such as BMI and age) and intraoperative factors (such as patellar thickness and size of the trochlear component) play a key role in optimising pre-operative planning to avoid intraoperative periprosthetic fractures.
Management and Complications of Dexamethasone Intravitreal Implant Migration Into the Anterior Chamber
Authors: Betsch Devin M. , Gupta R. Rishi 
Published: December 2022

Purpose: To report patient demographics, the clinical course, and visual outcomes across a case series of patients who experienced dexamethasone (DEX) intravitreal implant (Ozurdex, Allergan, Inc) migration into the anterior chamber (AC), with a focus on the corneal transplantation rate. Methods: In this retrospective cross-sectional study, a chart review of all cases was performed. For numerical responses, means and SDs were calculated. Percentages and absolute numbers were used to report the proportion of patients who experienced various outcomes of interest. Results: The study comprised 32 cases. All cases occurred in pseudophakic eyes; of those, 8 (25.0%) had posterior chamber intraocular lenses in the capsular bag with no known capsular or zonular issues. The mean duration from DEX implant injection to detection of migration was 19.4 ± 14.5 days. The DEX implant was explanted in 21 patients (65.6%) and repositioned in the vitreous cavity or subconjunctival space in 6 patients (18.8%). Twelve patients (37.5%) ultimately required corneal transplantation. Conclusions: To our knowledge, this is the largest case series of DEX intravitreal implant migration into the AC compiled to date. Cases of migration occurred in individuals with no known history of significant prior zonule disruption. This potential complication should be discussed with all patients undergoing DEX implant injection, which may aid in earlier presentation and improved visual outcomes.
An NFIX-mediated regulatory network governs the balance of hematopoietic stem and progenitor cells during hematopoiesis
Authors: Walker Megan , Li Yichao , Morales-Hernandez Antonio , Qi Qian , Parupalli Chaithanyarani , Brown Scott , Christian Claiborne , Clements Wilson K. , Cheng Yong , McKinney-Freeman Shannon 
Published: December 2022

Abstract
The transcription factor (TF) nuclear factor I-X (NFIX) is a positive regulator of hematopoietic stem and progenitor cell (HSPC) transplantation. Nfix-deficient HSPCs exhibit a severe loss of repopulating activity, increased apoptosis, and a loss of colony-forming potential. However, the underlying mechanism remains elusive. Here, we performed cellular indexing of transcriptomes and epitopes by high-throughput sequencing (CITE-seq) on Nfix-deficient HSPCs and observed a loss of long-term hematopoietic stem cells and an accumulation of megakaryocyte and myelo-erythroid progenitors. The genome-wide binding profile of NFIX in primitive murine hematopoietic cells revealed its colocalization with other hematopoietic TFs, such as PU.1. We confirmed the physical interaction between NFIX and PU.1 and demonstrated that the 2 TFs co-occupy super-enhancers and regulate genes implicated in cellular respiration and hematopoietic differentiation. In addition, we provide evidence suggesting that the absence of NFIX negatively affects PU.1 binding at some genomic loci. Our data support a model in which NFIX collaborates with PU.1 at super-enhancers to promote the differentiation and homeostatic balance of hematopoietic progenitors.