bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of family social support on postpartum quality of life: the structural equation modeling
Authors: khademi Khadijeh , Kaveh Mohammad Hossein , Ghahremani Leila , Nazari Mahin , Karimi Masoud 
Published: May 2022

Abstract
Background: The postpartum period is one of the most important stressful situations in women's lives that affects their quality of life (QOL). The important factor affecting the QOL in the postpartum period is social support, especially family social support (FSS). The present study has been designed to assess the impact of FSS on postpartum quality of life (PQOL).Methods: In this analytical cross-sectional study, 240 postpartum women completed the PQOL questionnaire, and FSS questionnaire (FSSQ). The Pearson correlation and multivariate regression were used to determine the relationship between variables. A structural equation model (SEM) was used for path mapping of the impact of FSS on PQOL.Results: The mean scores of PQOL and FSS were 61.63±9.59 and 69.80±11.19 respectively. The fit indices of the SEM were GFI: 1.00 and NFI: 1.00 that demonstrated, the fit of the SEM can be acceptable. The family support seeking (0.16), emotional support seeking (-0.13) and FSS (0.12) were three factors that influenced PQOL.Conclusion: Our findings showed a picture of the association between FSS and the QOL of women in the postpartum period. The support from the family as the first people around the women who gave birth can improve their QOL by improving their physical, mental, and childcare performance and can be very effective in overcoming this challenging situation.
Analysis of Contextual Features’ Granularity for Fake News Detection
Authors: Agarwal Isha , Rana Dipti , Panwala Kalp , Shah Raj , Kathiriya Viren 
Published: May 2022

Abstract

While the world is battling COVID-19 pandemic and its variants; neti- zens are combating Infodemic – “Proliferation of fake news online”. Spread of fake news during this global pandemic COVID-19 has dan- gerous consequences. Precise automated fake news detection is the need of the hour. This is the driving force behind this study. Intrin- sic quality of news data: precision and objectivity can be studied to detect the credibility. However, to gain the knowledge or infer- ence from it further it is a challenge. To address this challenge, this work proposes derivation of features into two categories: intrinsic word level features (Fine-grained) and sentence level features (Coarse- grained).For experimentation, fine-grained features are learned from word vector representation of the news articles. Psycho-linguistic and sentiment level word level features are derived using Empath library. Coarse-grained features (sentence-level) comprise of vectors generated by Text summarizationand DOC2Vec. Taking the advantages of existing approaches, this paper proposes a new framework GRAnularity based Fake news Detection (GRAFED) that explores fusion of fine and coarse-grained features. The fusion of feature set is more powerful than individual fine or coarse-grained feature sets as they can cap- ture complex interdependence of words in the sentence along with the semantics. Exhaustive experimentation using traditional classifiers with hybrid granular feature vector of GRAFED outperformed the existing approaches for publicly available state-of-art LIAR dataset. Experimental results show that the hybrid feature set is superior to individual feature set and the results are promising when compared to the existing state-of-art approaches as analysed in the comparative analysis section.
A Novel Elasto-Geometric Model Exploiting Loaded Circular Test on a Machine Tool
Authors: Beglarzadeh Babak , Mayer René , Archenti Andreas 
Published: May 2022

Abstract
A novel elasto-geometric model is introduced that simultaneously estimates joint compliances and geometric error parameters by employing the loaded double ball bar apparatus. The model parameters are estimated from tests at different force levels by distinguishing between errors that change with the applied force (compliance effect) from those that do not (geometric effects). At lower forces, the geometric errors are dominant whilst at higher forces compliance-induced errors dominate. By feeding the elasto-geometric model with pairs of adjacent force data the evolution of the estimated equivalent local compliance parameters and geometric errors with changes in the applied force are observed. Although theoretically unexpected, the estimated geometric errors also change across the force range. As the force increases the majority of equivalent compliance terms increase such as the dominant equivalent compliances CXXX and CYYY as well as the less significant compliances CXYX and CCCY. As for CCXY and CCYY, no clear trend was observed. Given this observed dependence of the compliance on the force level, the model was enriched by modeling the compliances as linear functions of the applied force. A single set of geometric errors could then be estimated and deemed valid across the load range. The root mean square error (RMSE) value for predicting the radial readings for all force levels for the constant and linearly variable compliance models are 0.0011 and 0.0009 mm, respectively, representing an 18% improvement for the linear compliance model. Both the constant and linearly variable compliance models exhibit over 91% fit to the experimental data with just over 1% improvement for the linear compliance model.
The “Y”-shaped Denonvilliers’ fascia and its adjacent relationship with the urogenital fascia based on the male cadaveric anatomical study
Authors: Yi Li , Ya-Min Zhao , Yan-Bing Ma , Jin-Song Zhou , Cong Tong , Li-Kun Yan Yan 
Published: May 2022

Abstract
Purpose The controversies about the anatomical structure of the Denonvilliers’ fascia and the relationship with surrounding fasciae have sparked a heated discussion, especially about whether it contains multilayers. This study aimed to expound on the anatomical structure of the Denonvilliers’ fascia and its correlation with the peritoneum from the sagittal position and clarify the complex fasciae relationship. MethodsOur study was performed on 20 adult male pelvic specimens fixed in formalin, including 2 entire pelvic specimens and 18 semi-pelvic specimens. By dissecting the local adjacent organs and fasciae, the Denonvilliers’ fascia was observed and removed for histological examination. ResultsAlmost the Denonvilliers’ fascia was a single layer and tough fascia. In the sagittal position, the peritoneum constituting peritoneum reflection and the Denonvilliers’ fascia showed a “Y” shape. The Denonvilliers’ fascia was originated from the peritoneum reflection, continually ran on the ventral side of the seminal vesicles and prostate, terminated at the perineal body, and gradually both sides thinned to fuse with the urogenital fascia (UGF). In addition, the histology preliminarily manifested that the basal cell layers of the peritoneum and that of the Denonvilliers’ fascia were continuous, and they also showed a “Y” shape. Also, the basal cells of the two peritonea extended to the Denonvilliers’ fascia, showing a fused double-layer structure. Some tiny blood vessels or a network of them extended from the peritoneum to the Denonvillier’ fascia.ConclusionAs the extension of the peritoneum in the pelvic floor, the Denonvilliers’ fascia is a “Y”-shaped monolayer layer fascia in the sagittal position. Our study provides new support for the peritoneum fusion theory of it. Understanding the anatomical characteristics of the Denonvilliers’ fascia and its relationship with the UGF is a guiding significance for youth colorectal surgeons to conduct rectal cancer surgery.
A Cross-sectional Analysis of MEP Urine Content and Asthma Incident in US Children and Adolescents
Authors: Cao Ren Shuang , Huang Tian Jiao , Zhang Wei , Yang Fan , Liu Xue , Yan Xiao Yan 
Published: May 2022

Abstract
Objectives: To explore the potential association between MEP Urine Content and Asthma Incident and to provide a reference for asthma control strategies for Children and Adolescents.Setting: Multivariate regression was used to evaluate the association between MEP urine content and adolescents and children Asthma Incident.Participants: Participants aged 20 years below who participated in the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2018 were eligible.Results: Potential association of increased urinary MEP levels with self-reported risk of asthma events in people under 20 years of age (OR 1.3, 95%CI: 1.1, 1.5). After stratified analysis of age and sex, the intimate relationship was stronger in the group of female children and adolescents aged 6 to 19 years (OR 1.3, 95%CI: 1.1, 1.7).Conclusions: This study suggests that MEP Urine Content is associated with self-reported asthma Incident in US children and adolescents. Asthma prevention measures for children and adolescent’s female should include cautious toiletry selection and avoid continuous, high-dose environmental exposure to Diethyl phthalate whenever possible. Furthermore, the conclusion may need to be supported by other randomized controlled trials or cohort studies.
Application of two-component neural network for exchange-correlation functional interpolation
Authors: Ryabov Alexander , Akhatov Iskander , Zhilyaev Petr 
Published: May 2022

Abstract
Density functional theory (DFT) is one of the primary approaches to solving the many-body Schrodinger equation. The essential part of the DFT theory is the exchange-correlation (XC) functional, which can not be obtained in analytical form. Accordingly, the accuracy improvement of the DFT is mainly based on the development of XC functional approximations. Commonly, they are built upon analytic solutions in low-and high-density limits and result from quantum Monte Carlo or post-Hartree-Fock numerical calculations. However, there is no universal functional form to incorporate these data into XC functional. Instead, various parameterizations use heuristic rules to build a specific XC functional. The neural network (NN) approach to interpolate the data from higher precision theories can give a unified path to parametrize an XC functional. Moreover, data from many existing quantum chemical databases could provide the XC functional with improved accuracy. We develop NN XC functional, which gives exchange potential and energy density without direct derivatives of exchange-correlation energy density. Proposed NN architecture consists of two parts NN-E and NN-V, which could be trained in separate ways, adding new flexibility to XC functional. We also show that the developed NN XC functional converges in the self-consistent cycle and gives reasonable energies when applied to atoms, molecules, and crystals.
Effects of a glyphosate-based herbicide on accessory sex glands morphology and functions of Chinese mitten crab (Eriocheir sinensis)
Authors: Xiaowen Yu , Yang Xiaozhen , Sun Ningbo , Shi Xingliang , Cheng Yongxu 
Published: May 2022

Abstract
Glyphosate-based herbicide (GBH) is a broad-spectrum and popular herbicide, which may contaminate the aquatic environment through various routes and impact aquatic animals. In this study, the morphology, the function to digest the spermatophore walls and causes, antioxidant capacities, energy reserves, and metabolism enzyme activities of accessory sex glands (ASGs) were evaluated after Chinese mitten crab (Eriocheir sinensis) exposed to GBH (48.945 mg/L, 1/2 of the 96 h LC50 value of GBH) for 7 days. After GBH exposure, vacuolar degeneration in ASGs can be observed. The function of ASGs to digest spermatophore walls was affected as accompanied by the decreased expression levels of cathepsin A (cathA) and activities of ACP in ASGs. The activities of superoxide dismutase (SOD), catalase (CAT), and total antioxidant capacity (T-AOC) in ASGs were significantly decreased, the contents of malondialdehyde (MDA) and protein carbonyl (PCO) were significantly increased. The contents of protein and glycogen were significantly decreased, and the activities of lactate dehydrogenase (LDH) were significantly decreased in AGSs. These results revealed that GBH can damage the reproductive health of E.sinensis by impairing ASGs morphology, weakening the function of ASGs to digest spermatophore walls, decreasing antioxidant capacities, and affecting energy reserves and metabolism in ASGs.
Historical and Future Trends in Emergency Pituitary Referrals: A Machine Learning Analysis
Authors: Pandit A. S. , Khan D. Z. , Hanrahan J. G. , Dorward N. L. , Baldeweg S. , Nachev P. , Marcus H. J. 
Published: May 2022

Abstract
Purpose Acute pituitary referrals to neurosurgical services frequently necessitate emergency care. Yet, a detailed characterisation of pituitary emergency referral patterns, including how they may change prospectively is lacking. This study aims to evaluate historical and current pituitary referral patterns and utilise state-of-the-art machine learning tools to predict future service use. Methods A data-driven analysis was performed using all available electronic neurosurgical referrals (2006-2022) to the busiest U.K. pituitary centre. Pituitary referrals were characterised and volumes were predicted using an auto-regressive moving average model with a preceding seasonal and trend decomposition using Loess step (STL-ARIMA), compared against a Convolutional Neural Network-Long Short-Term Memory (CNN-LSTM) algorithm and Prophet. Mean absolute, and percentage error scoring metrics with cross-validation were employed to evaluate algorithm performance. Results 462 of 36224 emergency referrals were included (referring centres=48; mean patient age=56.7-years, female:male=0.49:0.51). Emergency medicine and endocrinology accounted for the majority of referrals (67%). The most common presentations were headache (47%) and visual field deficits (32%). Lesions mainly comprised tumours or haemorrhage (85%) and involved the pituitary gland or fossa (70%). The STL-ARIMA pipeline outperformed CNN-LSTM and Prophet algorithms across scoring metrics, with standard accuracy being achieved for 6-monthly and yearly predictions. Referral volumes significantly increased from the start of data collection with future projected increases (p<0.001). Conclusion This work is the first to employ large-scale data and machine learning to describe and predict acute pituitary referral volumes, estimating future demand and highlighting areas for service improvement.
Association between sperm MT-COX1 gene variations and semen quality in the Chinese Han population
Authors: Li Xiaoxiao , Chang Hongyang , Cai Bo , Zhang Linghan , Zhang Le , Guo Peipei , Xiao Bing , Li Qian , Liu Jing , Tong Lili , Xu Xiaoting , Mao Genhong 
Published: May 2022

Abstract
Backgroud: Male sperm quality has declined as a whole in the last 30 years and our previous study found that there are many specific variations in male sperm mitochondria, including MT-COX1. In this study we attempted to explore the correlation between human sperm MT-COX1 gene variations and male semen quality in a Chinese Han population. Methods and results: There were 477 male patients from the Second Affiliated Hospital of Zhengzhou University from 2010 to 2021, of whom 331 were retrospective studies and 146 were prospective studies. And 4 oligoasthenoteratospermia samples and 13 normal sperm samples were collected for low-throughput sequencing of the whole human genome. The semen samples were divided into three groups according to the types of genetic variation at the m.6023G>A locus: G/G genotype (wild type), G/A genotype and A/A genotype. The results of a prospective study show that the A/A genotype had higher sperm density and motility than the G allele carrier (G/G+G/A). And DNAAF6 gene variation may be associated with oligoasthenoteratospermia, the upstream of the 107243978 position of DNAAF6 gene variation might have the binding of hsa-miR-4311 to the 3'UTR of DNAAF6 gene. Conclusions: We first found that the MT-COX1 gene of spermatozoa of the Chinese Han population has varied since 2014. Furthermore, the A/A genotype had better sperm quality than the G allele carriers (G/G+G/A), and the 107243978 position variation of the DNAAF6 gene might affect the gene expression by affecting the stability of transcripts.
Characterization of the flavor, sensory quality and in vitro bioaccessibility in cloudy pomegranate juice treated by high pressure and thermal processing
Authors: Tian Jun , Cheng Fengyun , Yun Yurou , Yi Junjie , Cai Shengbao , Zhou Linyan 
Published: May 2022

Abstract
Recently, cloudy pomegranate juice (PJ) becomes popular due to its rich in phenolics and health-promoting effects. The present work aimed to evaluate the application of high hydrostatic pressure processing (HPP), pasteurization (PT) and high-temperature short-time sterilization (HTST) on physicochemical properties (color, flow behaviour, turbidity, sugars, organic acids, aroma and sensory evaluation) and in vitro bioaccessibility of total phenols content (TPC), entire flavonoids content (TFC) and phenolics of cloudy PJ. Compared to HPP, thermal sterilization significantly increased the L*, a*, ΔE and turbidity and decreased the TPC, and TFC. HPP better maintained the volatile profile of cloudy PJ, while thermal sterilization significantly changed it by reducing alcohols by 23.8%-32.7% and increasing acids by 33.6%-182.8%. The bioaccessibility of flavonoids, phenolic acids, and tannins in control cloudy PJ after in vitro oral-gastric-intestinal digestion was 1.5%, 4.9%, and 9.0%, respectively, which were not significantly changed by different treatments. These results contributed to promoting the color quality and health benefits of cloudy PJ rich in phenolics by optimizing the processing conditions in the food industry.
Single-cell sequencing reveals the landscape of the tumor microenvironment in a skeletal undifferentiated pleomorphic sarcoma patient
Authors: Yuan Liu-Liu , Chen Zhong , Qin Jian , Qin Cheng-Jiao , Bian Jing , Dong Rui-Fang , Yuan Tang-Bo , Xu Yi-Ting , Kong Ling-Yi , Xia Yuan-Zheng 
Published: May 2022

Abstract
Background: Skeletal undifferentiated pleomorphic sarcoma (SUPS) is an invasive pleomorphic soft tissue sarcoma with a high degree of malignancy and a poor prognosis, it is prone to recur and metastasize. The tumor microenvironment and pathophysiology of SUPS are poorly characterized. Progress in single-cell RNA sequencing (scRNA-seq) provides an opportunity to dissect the pathophysiology of human diseases at unprecedented resolution, particularly in diseases lacking animal models, such as SUPS.Methods: We performed scRNA-seq on tumor tissues and paracancer tissues from a patient with SUPS. We identified the cell types and corresponding marker genes in this SUPS case. We applied copy number karyotyping of aneuploid tumors (CopyKAT) to distinguish malignant cells from normal cells of fibroblasts.Results: We further showed that CD8+ exhausted T cells and Tregs highly expressed PDCD1, CTLA4 and TIGIT. We identified PDCD1, CTLA4 and TIGIT as potential targets in this case. Our study identified eight malignant fibroblast subsets in SUPS with distinct gene expression profiles. C1-malignant Fibroblast and C6-malignant Fibroblast in the tumor microenvironment play crucial roles in tumor growth, angiogenesis, metastasis, and immune response. Thus, targeting malignant fibroblasts could represent a potential strategy for treating this patient. Intervention via tirelizumab enabled disease control, and immune checkpoint inhibitors (ICIs) of PD-1 could be considered the first-line therapy for patients with SUPS. Conclusion: Thus, scRNA-seq analyses guided successful therapeutic intervention in the SUPS patient, improved our understanding of complex human diseases and provided an alternative approach to personalized medicine.
Thymidine Phosphorylase facilitates Retinoic Acid Inducible Gene-I induced endothelial dysfunction
Authors: Baris Adrian , Fraile-Bethencourt Eugenia , Khou Sokchea , Anand Sudarshan 
Published: May 2022

Abstract
Activation of nucleic acid sensors in endothelial cells (ECs) has been shown to drive inflammation across pathologies including cancer, atherosclerosis and obesity. We previously showed that enhancing cytosolic DNA sensing by inhibiting three prime exonuclease 1 (TREX1) in ECs led to EC dysfunction and impaired angiogenesis. Here we show that activation of a cytosolic RNA sensor, Retinoic acid Induced Gene 1 (RIG-I) diminishes EC survival, angiogenesis and triggers tissue specific gene expression programs. We discovered a RIG-I dependent 7 gene signature that affects angiogenesis, inflammation and coagulation. Among these, we identified the thymidine phosphorylase TYMP as a key mediator of RIG-I induced EC dysfunction via its regulation of a subset of interferon stimulated genes. Pharmacological inhibition of TYMP rescues RIG-I induced EC death, migration arrest and restores sprouting angiogenesis. Interestingly, using RNAseq we identified a gene expression program that was RIG-I induced but TYMP dependent. Analysis of this dataset indicated that IRF1 and IRF8 dependent transcription is diminished in RIG-I activated cells when TYMP is inhibited. Functional RNAi screen of our TYMP dependent EC genes, we found that a group of 5 genes - Flot1, Ccl5, Vars2, Samd9l and Ube2l6 are critical for endothelial cell death mediated by RIG-I activation. Our observations identify mechanisms by which RIG-I drives EC dysfunction and define pathways that can be pharmacologically targeted to ameliorate RIG-I induced vascular inflammation.
Strategies for enhancing efficient generation of mice via CRISPR/HDR-mediated knock-in
Authors: Mathew Saumya Mary 
Published: May 2022

Abstract
CRISPR/Cas9 framework is generally used to generate genetically modified mouse models. The CRISPR (clustered regularly interspaced short palindromic repeat) gene editing technique, can efficiently generate knock-outs using the non-homologous end-joining (NHEJ) repair pathway. Small knock-ins also work precisely using a repair template with help of homology-directed-repair (HDR) mechanism. However, when the fragment size is larger than 4- 5 kb, the knock-in tends to be error prone and the efficiency decreases. Certain types of modifications, in particular insertions of very large DNA fragments(10–100kb) or entire gene replacements, are still difficult. The HDR process needs further streamlining and improvement. Here in this review, we describe methods to enhance the efficiency of the knock-in through checking each step from the guide design to the microinjection and choice of the oocyte donors. This helps in understanding the parameters that can be modified to get improved knock-in efficiency via CRISPR targeting.