bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyperthermic intraperitoneal chemotherapy in the treatment of recurrent ovarian cancer: When, and for whom?
Authors: Ayhan Ali , Akilli Huseyin , Abasiyanik Mehmet Ali , Taskiran Cagatay 
Published: October 2022

AbstractObjectiveThe aim of this study is to evaluate the progression‐free survival (PFS) of recurrent ovarian cancer (ROC) patients treated with cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (HIPEC).Materials and MethodsROC patients who underwent cytoreductive surgery plus HIPEC between 2015 and 2021 were retrospectively evaluated. Patients' demographic information and clinicopathological characteristics including cancer type, histology, platinum status, presence of ascites, type of surgery, complications, chemotherapy history, and disease progression were documented. PFS was calculated using the Kaplan–Meier method.ResultsA total of 104 patients with ROC were included. The median age was 57 years and the median follow‐up time was 15 months (range: 5–69 months). In Cox regression multivariate analyses, platinum resistance (hazard ratio [HR]: 3.32, 95% confidence interval [CI]: 1.91–5.76, p = 0.00), more than one relapse prior HIPEC (HR: 2.81, 95% CI: 1.65–4.87, p = 0.024), and presence of ascites (HR: 1.88, 95% CI: 1.08–3.26, p = 0.00) were found to be negative prognostic factors for PFS. In subgroup analyses of patients with the first recurrence, the median PFS was 21 months for platinum‐sensitive patients and 6 months for platinum‐resistant patients (p = 0.032).ConclusionHIPEC at the time of first platinum‐sensitive relapse may lead to favorable PFS in the treatment ROC. However, HIPEC as salvage treatment even with R0 cytoreductive surgery does not seem effective.
Ex vivo proton spectroscopy (1H‐NMR) analysis of inborn errors of metabolism: Automatic and computer‐assisted analyses
Authors: Cannet Claire , Frauendienst‐Egger Georg , Freisinger Peter , Götz Hermann , Götz Madalina , Himmelreich Nastassja , Kock Vanessa , Spraul Manfred , Bus Christine , Biskup Saskia , Trefz Friedrich 
Published: October 2022

AbstractThere are about 1500 genetic metabolic diseases. A small number of treatable diseases are diagnosed by newborn screening programs, which are continually being developed. However, most diseases can only be diagnosed based on clinical symptoms or metabolic findings. The main biological fluids used are urine, plasma and, in special situations, cerebrospinal fluid. In contrast to commonly used methods such as gas chromatography and high performance liquid chromatography mass spectrometry, ex vivo proton spectroscopy (1H‐NMR) is not yet used in routine clinical practice, although it has been recommended for more than 30 years. Automatic analysis and improved NMR technology have also expanded the applications used for the diagnosis of inborn errors of metabolism. We provide a mini‐overview of typical applications, especially in urine but also in plasma, used to diagnose common but also rare genetic metabolic diseases with 1H‐NMR. The use of computer‐assisted diagnostic suggestions can facilitate interpretation of the profiles. In a proof of principle, to date, 182 reports of 59 different diseases and 500 reports of healthy children are stored. The percentage of correct automatic diagnoses was 74%. Using the same 1H‐NMR profile‐targeted analysis, it is possible to apply an untargeted approach that distinguishes profile differences from healthy individuals. Thus, additional conditions such as lysosomal storage diseases or drug interferences are detectable. Furthermore, because 1H‐NMR is highly reproducible and can detect a variety of different substance categories, the metabolomic approach is suitable for monitoring patient treatment and revealing additional factors such as nutrition and microbiome metabolism. Besides the progress in analytical techniques, a multiomics approach is most effective to combine metabolomics with, for example, whole exome sequencing, to also diagnose patients with nondetectable metabolic abnormalities in biological fluids. In this mini review we also provide our own data to demonstrate the role of NMR in a multiomics platform in the field of inborn errors of metabolism.
‘The giving layer of the internet’: A critical history of GoFundMe's reputation management, platform governance, and communication strategies in capturing peer‐to‐peer and charitable giving markets
Authors: Wade Matt 
Published: October 2022

AbstractGoFundMe, founded in 2010, has already profoundly impacted giving practices, introducing many laypersons to the empowering potentials and user‐friendly affordances of peer‐to‐peer fundraising. Overall, GoFundMe's extraordinary success as a for‐profit company in traditionally nonprofit charitable giving markets can be attributed to: normalizing their platform as the go‐to destination for people seeking help; tasking the beneficiaries themselves with crafting appeals for support; restricting forms of support to money; deferring responsibility to donors to assess the legitimacy of appeals; and dominating the market by acquiring competitors and pursuing growth wherever possible. No charity could plausibly adopt such an operating model and GoFundMe's lean, hands‐off, self‐policing approach has attracted sharp criticism over the years. Nonetheless, the company has not humbly reined in their ambition but expanded it even further. This paper outlines three broad phases through which GoFundMe has defended their capture of “the giving layer of the internet.” Initially, GoFundMe espoused ideals of utopian disruption and soteriological solutionism, selling their platform as a “take‐action button” and user‐friendly means of empowering everyday citizens to improve the lives of others. Later, after attracting more divisive causes and criticisms of its revenue model, GoFundMe adopted forms of reputational repair and attempted neutrality, insisting that their for‐profit platform could be accommodative to all worldviews and persons willing to embrace “positive precarization.” More recently, as “neutral” stances became untenable and fundraising success rates increasingly grim, GoFundMe pivoted toward strategies of state critique and civic capture. Specifically, GoFundMe have: more pointedly highlighted state failures; actively aligned themselves with social movements; shifted away from relying solely on peer‐to‐peer fundraising; and instead partnered more with established nonprofits. However, as GoFundMe's expansion inevitably means becoming entangled in sensitive political matters, the company's ambition to become the key intermediary in all charitable giving is facing acute challenges.
TMT29 plex: Higher order multiplexing with inherent interference correction
Authors: Zhang Tian 
Published: October 2022

AbstractTandem mass tag (TMT) technology enables mass spectrometry‐based multiplexed sample profiling of protein abundance. The degree of isobaric labeling with TMT has increased from 2 to 6, 11, 16 [1] and recently 18 [2] channels, enabling the development of higher throughput assays. In TMT experiments, measurement of reporter tag intensities is confounded by ratio compression. Although both pre‐ and post‐acquisition methods have been developed to decrease interference, ratio compression remains a problem in complex samples. The work of Sun et al. presented a TMT29‐plex workflow that combines the TMT11‐plex and TMTpro18‐plex labeling strategies and uses their inherent features to address the ratio compression problem, increasing the TMT throughput and quantitative accuracy for potential applications [3].
Serum 25‐hydroxyvitamin D deficiency is associated with atopy, and sex may be an effect modifier of its association with asthma in teenagers from northeast Brazil
Authors: Alcantara Galvão Alana , de Andrade Belitardo Emília M. M. , de Araújo Sena Flávia , Santos Juliana M. , de Oliveira Costa Gustavo N. , Feitosa Caroline A. , Fiaccone Rosemeire L. , Cruz Álvaro A. , Barreto Maurício L. , Figueiredo Camila A. , Alcantara‐Neves Neuza M. 
Published: October 2022

AbstractObjectiveSufficient vitamin D (25‐hydroxyvitamin D [25(OH)D]) serum levels are associated with decreased asthma symptoms. Our aim was to investigate associations between vitamin D and atopy, asthma, asthma severity, and asthma phenotypes in Brazilian teenagers.MethodsThis cross‐sectional study involved 942 individuals (11–19 years old) engaged in an asthma cohort. The ISAAC questionnaire was employed to diagnosis asthma and asthma severity. Serum allergen‐specific immunoglobulin E (sIgE) was measured by ImmunoCap and serum 25(OH)D was measured by ELISA. We calculated the correlation between sIgE and 25(OH)D. We used multivariate logistic regression analysis to assess associations of interest.ResultsWe found that 25(OH)D deficiency was positively associated with atopy (OR 1.45, confidence interval [CI] 1.05–2.00) and high levels of this vitamin negatively correlated with sIgE to Dermatophagoides pteronyssinus (r = −0.11, p = 0.019). The average 25(OH)D serum level was 27.0 ± 9.5 ng/ml; 366 individuals (38.8%) had a sufficient level. There was no association between 25(OH)D and asthma, asthma severity or asthma phenotypes in the population. However, sex was a possible effect modifier of the association between vitamin D and asthma: insufficiency in asthmatic women (86%) was higher than in asthmatic men (42%), and there was an association between insufficient vitamin D levels and greater asthma risk only in women (OR = 3.06, 95% CI 1.16–8.07).ConclusionWe have shown that vitamin D deficiency was associated with greater risk of atopy in both sexes and vitamin D insufficiency was associated with asthma only in women. There was no association between vitamin D levels and asthma phenotypes or asthma severity.
Computed cancer interactome explains the effects of somatic mutations in cancers
Authors: Zhang Jing , Pei Jimin , Durham Jesse , Bos Tasia , Cong Qian 
Published: October 2022

AbstractProtein–protein interactions (PPIs) are involved in almost all essential cellular processes. Perturbation of PPI networks plays critical roles in tumorigenesis, cancer progression, and metastasis. While numerous high‐throughput experiments have produced a vast amount of data for PPIs, these data sets suffer from high false positive rates and exhibit a high degree of discrepancy. Coevolution of amino acid positions between protein pairs has proven to be useful in identifying interacting proteins and providing structural details of the interaction interfaces with the help of deep learning methods like AlphaFold (AF). In this study, we applied AF to investigate the cancer protein–protein interactome. We predicted 1,798 PPIs for cancer driver proteins involved in diverse cellular processes such as transcription regulation, signal transduction, DNA repair, and cell cycle. We modeled the spatial structures for the predicted binary protein complexes, 1,087 of which lacked previous 3D structure information. Our predictions offer novel structural insight into many cancer‐related processes such as the MAP kinase cascade and Fanconi anemia pathway. We further investigated the cancer mutation landscape by mapping somatic missense mutations (SMMs) in cancer to the predicted PPI interfaces and performing enrichment and depletion analyses. Interfaces enriched or depleted with SMMs exhibit different preferences for functional categories. Interfaces enriched in mutations tend to function in pathways that are deregulated in cancers and they may help explain the molecular mechanisms of cancers in patients; interfaces lacking mutations appear to be essential for the survival of cancer cells and thus may be future targets for PPI modulating drugs.
CRISPR/Cas9‐mediated D472N substitution in the Rdl1 of Plutella xylostella confers low resistance to abamectin
Authors: Sun Xi , Hua Wenjuan , Zhu Bin , Liang Pei , Gao Xiwu 
Published: October 2022

AbstractBackgroundAbamectin is one of the main insecticides used for the control of Plutella xylostella, a destructive pest of cruciferous crops. Target‐site mutation plays an important role in insecticide resistance. A point mutation (D472N) has been reported in the Rdl1 γ‐aminobutyric acid receptor (GABAR) in P. xylostella, but its roles in insecticide resistance remain unknown.ResultsIn this study, the D472N mutation of the Rdl1 GABAR was detected in several field populations of P. xylostella and showed a positive correlation with abamectin resistance. A knock‐in homozygous mutation strain (D472N‐KI) of P. xylostella was successfully constructed using CRISPR/Cas9 coupled with homology‐directed repair, and the bioassay results demonstrated that compared with the susceptible strain, the D472N‐KI strain had 11.1‐ and 3.7‐fold increased resistance to abamectin and endosulfan, respectively. There was no difference in resistance to fipronil, broflanilide or isocycloseram, which also target the GABAR. In addition, the total fecundity of the D472N‐KI strain was significantly reduced by 50.0%.ConclusionOur results suggest that the homozygous D472N mutation in Rdl1 confers a low level of resistance to abamectin in P. xylostella but causes significant fecundity disadvantages, which may delay the development of resistance to some extent. These results lay a foundation for further understanding the mechanisms of abamectin resistance in insect pests. © 2022 Society of Chemical Industry.
Fault detection problem for discrete‐time impulsive system using mixed dissipativity approach
Authors: Yao Meng , Wei Guoliang , Li Wangyan 
Published: October 2022

AbstractThis article studies the fault detection problem for a class of discrete‐time impulsive systems using mixed dissipativity theory. First, under the impulsive effects, a fault diagnosis observer is designed such that it is insensitive to disturbances, and sensitive to faults. Then, a mixed dissipativity concept is introduced to deal with impulsive effects, disturbances insensitivity condition and faults sensitive condition in one framework such that the impulsive error dynamic is dissipative with respect to the proposed mixed supply rate. Based on the proposed mixed supply rate, sufficient conditions are obtained to guarantee the dissipativity of the impulsive estimation error dynamic. Moreover, sufficient conditions are established for the existence of the desired fault observer. The corresponding solubility conditions for the designs of the desired observer are also obtained. Finally, simulation results are proposed to demonstrate the effectiveness of our proposed strategy.
Gastrulation and hatch as critical thermal windows for salmonid embryo development
Authors: Bloomer Jack , Anderson James J. , Sear David , Greene Sheila , Gantner Drew , Hanson Charles 
Published: October 2022

AbstractClimate change and impoundment increase river temperatures, shifting the bioclimatic envelope in which freshwater biota have evolved and increasing salmonid egg mortality. To mitigate this, conservation flows from reservoirs are often implemented to maintain favourable water temperatures downstream from impoundments throughout salmonid embryo development. However, as water to maintain conservation flows becomes scarcer, there is a need to understand the requirements of salmonid embryos and balance these with anthropogenic demands. This study combines a laboratory‐based and a modelling approach to test the effect of different temperatures on the survival from fertilisation to hatch of a model salmonid species. Further, the effect of dropping temperatures from high to optimal conditions at hatch—a perceived period of greater sensitivity to high temperatures—is tested. The study shows embryo mortality increases with temperature and is greatest during gastrulation and hatch. Also, embryos that experienced high temperatures during gastrulation had high mortality rates at hatch, even when hatch conditions were optimal. This indicates sublethal developmental abnormalities caused by high temperatures during gastrulation increase mortality at hatch. Therefore, to maintain high rates of salmonid embryo survival, cold water resources from reservoirs ideally will target both gastrulation and hatch developmental stages.
Direct detection of pseudo-Nambu-Goldstone dark matter in a two Higgs doublet plus singlet extension of the SM
Authors: Biekötter Thomas , Gabriel Pedro , Olea Romacho María Olalla , Santos Rui 
Published: October 2022

Abstract
We calculate the leading radiative corrections to the dark-matter-nucleon scattering in the pseudo-Nambu-Goldstone dark matter model augmented with a second Higgs doublet (S2HDM). In this model, the cross sections for the scattering of the dark-matter on nuclei vanishes at tree-level in the limit of zero momentum-transfer due to a U(1) symmetry. However, this symmetry is softly broken in order to give a mass to the dark-matter particle. As a consequence, non-vanishing scattering cross sections arise at the loop level. We find that the current cross-section limits from dark-matter direct-detection experiments can hardly constrain the parameter space of the S2HDM. However, the loop-corrected predictions for the scattering cross sections can be well within the reach of future direct-detection experiments. As a consequence, future phenomenological analyses of the S2HDM should take into account cross-section predictions beyond tree-level and the experimental constraints from dark-matter direct-detection experiments.
Kidney Transplantation and Obesity: Are There Any Differences in Outcomes?
Authors: Moein Mahmoudreza , Otero Melanie Tacher , Rood Gavrielle J. , Hanlon Matthew , Saidi Reza 
Published: October 2022

AbstractIntroductionKidney transplantation (KT) is the gold standard treatment for end‐stage renal disease (ESRD) patients. Obesity is a strong risk factor for developing cardiovascular disease, chronic kidney disease, and ESRD. This study aimed to investigate the outcomes of kidney transplantation in obese recipients.Material and methodsWe retrospectively reviewed the medical records of recipients from January 2016 to December 2021 in a single center. Outcomes in recipients of a kidney allograft with BMI ≥ 30 were compared with the outcomes in recipients with 30 < BMI.ResultsA total of 467 consecutive kidney transplantation recipients’ files were studied. 213 (45.6%) allograft recipients had a BMI ≥ 30, and 254 (54.4%) allograft recipients had a BMI < 30. DGF rate was 29.1% in the BMI ≥ 30 and 30.7% in the BMI < 30 group (P = 0.41). On the other hand, 30 days readmission rate also did not show a significant difference between the BMI ≥ 30 and BMI < 30 allograft recipients (37 vs. 33.8%, P = 0.46). The mean overall costs of transplantation in the BMI ≥ 30 group was $254,395, and it was $256,029 in the BMI < 30 group (P = 0.84).ConclusionOur study shows that the outcomes of renal allograft transplant were comparable between recipients with BMI ≥ 30 and BMI < 30 in terms of DGF, LOS, 30 days readmission, acute rejection rate, and survival rates, and BMI should not be a single independent criterion for decision making to select an optimal recipient.
Untersuchung des Einflusses von unterschiedlichen Fahrbahnzuständen auf die Fahrbarkeitsfunktionen elektrifizierter Fahrzeugantriebssysteme mittels eines Hardware-in-the-Loop-Prüfstands
Authors: Jakstas Gabrielius , Koch Andreas , Falkenstein Jens 
Published: October 2022

ZusammenfassungDer Antriebsstrang von Elektrofahrzeugen unterscheidet sich deutlich von Fahrzeugen mit Verbrennungsmotor. Aktuelle Konzepte im Bereich der elektrischen Fahrzeugantriebsstränge weisen aufgrund der einfachen Triebstrangmechanik meist eine geringe Reibung und damit wenig Dämpfung auf. Typischerweise gibt es keine Kupplung, um die träge Masse der elektrischen Antriebsmaschine vom restlichen Fahrzeugantriebsstrang zu trennen. Äußere (Fahrbahnunebenheiten, Schlaglöcher, etc.) und innere Anregungen (Drehmomentänderungen der elektrischen Maschine, Bremseingriffe) führen zu Dreh- bzw. Ruckelschwingungen und teilweise hohen Bauteilbelastungen. Diese können durch geeignete Fahrbarkeitsfunktionen reduziert werden. Ein gängiger, aus konventionellen Antriebssträngen bekannter Ansatz besteht in der Begrenzung der Steigung und weiteren Modifikationen des Solldrehmomentes bzw. des Fahrerwunschmoments, um den Drehmomentaufbau der Antriebsmaschine zu beeinflussen und die Anregung von Ruckelschwingungen zu reduzieren. Ein zweiter Ansatz ist die Verwendung eines Vorfilters. Das hier genutzte Vorfilter basiert auf der inversen Dynamik des Antriebsstrangs, um das Sollmoment der Antriebsmaschine zu beeinflussen, vernachlässigt jedoch die Einflüsse des Reifens, des Reifen-Fahrbahnkontakts und der Fahrzeuglängsdynamik. Dies hat den Vorteil, dass Beobachter und Schätzverfahren zur Bestimmung des Reifen-Fahrbahn-Kontaktes usw. nicht erforderlich sind. Jedoch muss die Wirksamkeit des Ansatzes bei unterschiedlichen Fahrbahnbeschaffenheiten sichergestellt sein. Ergänzt wird das Vorfilter durch eine aktive Anti-Ruckel-Regelung.In diesem Artikel wird der Einfluss von variierenden Fahrbahnzuständen auf die Wirksamkeit des hier angewandten Vorfilters realitätsnah untersucht. Diese Untersuchungen sind notwendig, um eine sicherere Aussage über die Funktionalität der entwickelten Steuerungsalgorithmen in realen Fahrzeugen bei unterschiedlichen Fahrbahnzuständen treffen zu können. Vergleichbare reale oder realitätsnahe Untersuchungen sind bisher nur begrenzt verfügbar. Für realitätsnahe Fahrzeugbedingungen werden Fahrmanöver auf einem Hardware-in-the-Loop-Prüfstand durchgeführt.
Specific Pandemic-Related Worries Predict Higher Attention-Related Errors and Negative Affect Independent of Trait Anxiety in UK-Based Students
Authors: Brown Chris R. H. , Feng Ya-Chun , Costin Vlad , Hirsch Colette R. , Wang Yun-Han , Wang Yun-Lin , Chew Jowinn , Kenny Jordan , Allen Paul 
Published: October 2022

Abstract
Background
The COVID-19 pandemic has resulted in many individuals experiencing increased symptoms of anxiety. We predict that this increase may be underpinned by pandemic-related worry (PRW), characterised by repetitive negative thinking about pandemic-specific outcomes; and that this relationship is mediated through reduced attentional capacity required to regulate negative affect.

Methods
We developed a novel scale to measure the contents of PRW in an initial sample of 255 participants, and explored its relationship with cognitive functioning and negative affect in a sample of 382 UK-based university students, whilst controlling for recalled pre-pandemic trait anxiety.

Results
A five-factor model of PRW was identified, with factors reflecting worry about decline in quality of life (QoL) and probability of infection correlating with attention and memory-related errors. Importantly, attention-related errors partially mediated the positive relationship between PRW and negative affect, even when controlling for pre-pandemic trait anxiety.

Conclusion
PRW’s relationship with negative affect was partially mediated through attentional function, consistent with models of anxiety and attentional control. In UK-based students PRW may be predominantly focused on the decline in QoL; therefore, interventions targeting worry about the decline in QoL caused by COVID-19 are especially important in this population in the wake of the pandemic.