bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bacterial diversity associated with volatile compound accumulation in pit mud of Chinese strong-flavor liquor pit
Authors: Shoubao Yan , Yonglei Jia , Qi Zhang , Shunchang Pu , Cuie Shi 
Published: November 2022

Abstract
Pit mud quality is a key parameter that impacts the quality of Chinese strong-flavor liquor production.This study was developed to explore spatial bacterial community distributions and the relationships between these distributions and the volatile compound accumulation within the pit mud used in the production of Chinese strong-flavor liquor. The results revealed Lactobacillus pasteurii and Limnochorda pilosa were found to be the dominant bacteria present in the upper wall, middle wall, and bottom pit mud layers, whereas the Clostridium genus was detectable at high levels in the lower layer of the pit wall and played a role in contributing to the overall aroma and flavor compounds in produced Chinese strong-flavor liquor, with Clostridium abundance being strongly correlated with caproic acid, ethyl caproate, ethyl butyrate, and hexanol levels as well as moderately correlated with butyric acid levels. The abundance of the Lactobacillus genus was positively correlated with levels of ethyl lactate, 1-butanol, and 2,3-butanediol. Limnochorda pilosa was closely associated with ethyl acetate levels. Additionally, the correlations between bacterial communities and chemical properties was also investigated, and the results demonstrated PO43−, total carbon, K+, humus, NH4+-N, and Mg2+ levels significantly affected the bacterial community structure of pit mud, and they were strong positively correlated with the relative abundance of Clostridium. Together, these findings can serve as a foundation for future studies exploring the mechanisms whereby volatile compounds accumulate in different pit mud layers, which facilitates the fermentation regulation and pit mud quality improvement of Chinese strong-flavor liquor.
CO oxidation over Cu-Ce binary oxide prepared by solvothermal method: Effects of cerium precursors on the properties and catalytic behavior
Authors: Jin Wen , Liu Yanmin , Yu Jun , Mao Dongsen 
Published: November 2022

Abstract
Cu-Ce binary oxides were prepared by one-pot solvothermal method, and the effects of different cerium precursors (cerium nitrate and cerium ammonium nitrate) on the catalytic activity and resistance to water vapor or CO2 of the prepared samples for low-temperature CO oxidation reaction were investigated. The physico-chemical characteristics of the catalysts were characterized by thermal analyses (TG-DSC), X-ray diffraction (XRD), Raman spectroscopy, N2 adsorption-desorption, inductively coupled plasma-atomic emission spectrometry (ICP-AES), X-ray photoelectron spectroscopy (XPS), in-situ diffuse reflectance infrared Fourier transform spectroscopy (in-situ DRIFTs), temperature-programmed reduction with H2 (H2-TPR), and temperature-programmed desorption of adsorbed O2 (O2-TPD). The results indicated that the CuO-CeO2 catalyst (CC-N) prepared with cerium nitrate showed higher activity for low-temperature CO oxidation, which can be ascribed to its larger specific surface area and pore volume, more amounts of highly dispersed CuO species with strong interaction with CeO2, Cu+ species, and more active surface oxygen species, compared with the counterpart prepared with cerium ammonium nitrate (CC-NH). Furthermore, the CC-N catalyst also exhibited better resistance to CO2 poisoning than CC-NH.
A young maturity-onset diabetes of the young type 3 (MODY 3) in a non- HNF 1α-mutation family——case report
Authors: Peng Haoran , Li Jianbo , Wang Zhang 
Published: November 2022

Abstract
Young maturity-onset diabetes of the young type3(MODY3) as a special type of diabetes, the probability of being diagnosed is low. This article reports a case and reviews the relevant knowledge of the disease. We report an 11-year-and-11-month-old girl whose grandmother died of diabetic complications while the rest of the families were non-diabetes. The proband initially treated with insulin and metformin but inefficient. After exome-targeted capture sequencing test, she was diagnosed with maturity-onset diabetes of the young type 3 (MODY3), and sulfonylureas makes sense. The key to the treatment of mody is correct and timely diagnosis, which is contribute to help patients overcome the problems of MODY3, especially for blood sugar control.
Distributional National Accounts for Australia, 1991-2018
Authors: Fisher-Post Matthew , Hérault Nicolas , Wilkins Roger 
Published: November 2022

Abstract

We produce estimates of the full distribution of all national income in Australia for the period 1991 to 2018, by combining household survey with administrative tax microdata and adjusting to match National Accounts aggregates. From these estimates, we are able to rigorously document the shifts in income shares over the period, contrasting changes in the distribution of pre-tax and post-tax national income. Comparing Australia to the US and to France, we also compare our new results to traditional household survey-based estimates of inequality. Moreover, we exploit the richness of our unique microdata to shed light on the distribution of national income across and within various population groups not usually identifiable in the tax datasets that underpin reliable top-income estimates. Among our most surprising findings, inequality of post-tax national income is less than inequality of survey-based (post-transfer, disposable) income for Australia. The gender gap in income has stubbornly remained over the past three decades. Finally, we find that Australian inequality of national income is much lower than that of the United States, while it is similar to that of France, although those at the bottom of the income distribution fare better in France than in Australia.
JEL Codes: D31, D33, E01
Irisin ameliorates myocardial ischemia-reperfusion injury through modulation of gut microbiota and intestinal permeability in rats
Authors: Liu Qingqing , Zhu Yu , Li Guangyao , Guo Tiantian , Jin Mengtong , Xi Duan , Wang Shuai , Liu Xuezhi , Guo Shuming , Liu Hui , Fan Jiamao , Liu Ronghua 
Published: November 2022

Abstract
Purpose Irisin has a significant protection the myocardial from ischemia reperfusion (I/R) injury. Recent studies have suggested that the gut microbiota plays an important role in the progression of myocardial I/R injury. In this context, the aim of this study is to investigate whether Irisin interferes in gut microbiota and gut mucosal barrier during myocardial I/R injury. Methods All the rats received intraperitoneal injection of irisin or PBS, and then myocardial I/R rats disease model was established. Gut microbiota was analyzed by 16S rRNA high-throughput sequencing to assess changes in the microbiota. Colon and ileum tissue structural damage and apoptosis were evaluated by HE staining and Tunnel, respectively. Intestinal barrier integrity was valuated using by immunofluorescence to detecte the protein expression of ZO-1 and occludin and serum lipopolysaccharide. The proinflammatory cytokines (IL-1β, IL-6, TNF-α) in the colon and ileum tissue by Western Blot. Myocardial HE staining and serum cTnI, CK were performed to evaluate the cardiac function. Results Irisin treatment significantly improved the imbalance of intestinal flora in I/R rats. And irisin maintained intestinal barrier function by increasing the expression of ZO-1 and occludin protein in colon and ileum and and decreasing serum LPS concentration. Meanwhile, intestinal inflammation in I/R rats was attenuated by irisin. More importantly, irisin was protective against I/R injury in vivo. Conclusion Irisin intervention could improve the impaired gut mucosal barrier and reduce the production of LPS after I/R through regulating gut microbiota, thus inhibiting the inflammation and finally exerted the cardioprotective effect.
COVID-19 DNA Methylation Markers and Druggable Targets and Potential Malignant Diseases with Long Incubation Period
Authors: Zhang Zhengjun 
Published: November 2022

Abstract
COVID-19 research needs interactive reliable biomarkers at genomic and genetic levels. Earlier research has established the existence of genomic signature patterns and nearly perfect reliable interactive genomic biomarkers. However, reliable DNA methylation markers haven't been identified at the epigenetic level, not to mention interactiveness. This study utilized the newly proven and powerful method to discover nearly perfect interactive COVID-19 DNA methylation markers. From 865,859 methylation sites, a miniature set of seven Infinium MethylationEPIC sites (CpG sites, genes) and one intergenic region have been discovered to interact with each other and with disease subtypes. They lead to nearly perfectly (96.87% accuracy) predicting COVID-19 patients from patients presenting with respiratory symptoms but COVID-19. These seven CpG sites can jointly explain COVID-19-related diseases. These seven CpG sites and the optimum performed genomic biomarkers reported in our earlier work rise to be potential druggable targets. Among these seven CpG sites, diseases associated with cg16785077 (gene MX1) can have an incubation period of up to six to eight years, which raises a serious (or urgent) issue to investigate now or sooner.
Monitoring blood caffeine concentration in preterm infants: a retrospective observational study
Authors: Sugino Masashiro , Kuboi Toru , Noguchi Yuta , Nishioka Katsufumi , Tadatomo Yoko , Kawaguchi Nana , Sadamura Takaaki , Nakano Akiko , Konishi Yukihiko , Koyano Kosuke , Nakamura Shinji , Okada Hitoshi , Itoh Susumu , Kusaka Takashi 
Published: November 2022

Abstract
Therapeutic drug monitoring (TDM) is generally unnecessary in caffeine therapy for apnea of prematurity because the normal blood-caffeine concentrations of preterm infants are markedly lower than those at which caffeine intoxication occurs. However, several reports have mentioned preterm infants developing toxicity. In this retrospective observational study, conducted at a tertiary center in Kagawa, Japan, we evaluated the correlation between the maintenance dose and blood-caffeine concentrations and determined the maintenance dose leading to toxic caffeine concentrations.. Preterm infants were treated with caffeine citrate for apnea of prematurity between 2018 and 2021. Our primary outcome measure was the maintenance dose leading to toxic caffeine concentrations. Twenty-four preterm infants (gestational age, 27 ± 2.9 weeks; body weight, 991 ± 297 g) were included, and 272 samples were collected for analysis. The caffeine dose and blood-caffeine concentration were positively correlated (p < 0.05, r = 0.72). At doses of ≥ 8 mg/kg/day, 15% (16/109) of patients had a blood-caffeine concentration above the toxic concentration. Patients who receive doses of ≥ 8 mg/kg/day are at risk of reaching the toxic blood-caffeine concentration. Although it is unknown whether toxic caffeine concentrations are detrimental to neurological prognosis, the administration of high-dose (≥ 8 mg/kg/day) caffeine may require TDM to prevent blood-caffeine concentrations from reaching toxic levels.
Early Mars sub-aerial environments conducive to prebiotic evolution
Authors: Rapin William , Dromart Gilles , Clark Benton , Schieber Jürgen , Kite Edwin , Kah Linda , Thompson Lucy , Gasnault Olivier , Lasue Jérémie , Meslin Pierre-Yves , Gasda Patrick , Lanza Nina 
Published: November 2022

Abstract
Mars provides a unique record for early habitable environments 1–3 but its potential for an independent origin of life is uncertain 4,5. Prebiotic chemical evolution leading to incipient life requires specific environments and processes to occur 6. In particular, wet-dry cycling is known to strongly promote the self-assembly of organics, generating opportunistic mixtures and combinations of essential biopolymers 7–9. However, evidence for such process has been missing from the geological record of Mars explored so far. Here we report on new observations by the Curiosity rover at Gale crater indicating wet-dry cycling occurred on early Mars. We observed exhumed centimetric polygonal ridges, with distinct Y-junctions, which are characteristic of a fossilized cracking pattern that initially formed in fresh mud by the sustained action of wet-dry cycles. Given organics are present in the ancient sediments of Gale, our results suggest the evaporitic basin has been particularly conducive to prebiotic polymerization processes. The features are physically and temporally associated with the transition from clay to sulfate-bearing strata, a key mineral assemblage found elsewhere across Mars. It suggests that the Noachian-Hesperian transition (3.8 – 3.6 Gyrs ago) as a whole has been favorable to prebiotic evolution.
Receptor Tyrosine Kinase Inhibitors in Cancer Immunotherapy
Authors: Ebrahimi Nasim , Fardi Elmira , Ghaderi Hajarossadat , Palizdar Sahar , Khorram Roya , Vafadar Reza , Mobarak Halimeh , Ahmadi Amirhossein , Hamblin Michael R. , Aref Amir reza 
Published: November 2022

Abstract
Targeted therapy is a new cancer treatment approach, involving drugs that particularly target specific proteins in cancer cells, such as receptor tyrosine kinases (RTKs) which are involved in promoting growth and proliferation, Therefore inhibiting these proteins could impede cancer progression. An understanding of RTKs and the relevant signaling cascades, has enabled the development of many targeted drug therapies employing RTK inhibitors (RTKIs) that have entered clinical applications. Here we discuss RTK structures, activation mechanisms and functions. Moreover, we cover the potential effects of combination drug therapy (including chemotherapy drugs with one RTKI or multiple RTKIs) especially for drug resistant cancers.
Self-Reported Anatomical Characteristics of the Penis and Male Sexual Function
Authors: Niu Caoyuan , Ventus Daniel , Jern Patrick , Santtila Pekka 
Published: November 2022

Abstract
Premature ejaculation (PE) and erectile dysfunction (ED), which is common male sexual dysfunctions worldwide, lead to substantial distress in men as well as their partners, and decrease the quality and stability of romantic relationships, and, consequently, lead to a decreased quality of life in a large part of the population. We investigated the associations between self-reported anatomical characteristics of the penis and PE and ED in an urban Chinese sample. We recruited 1976 Chinese urban men aged 18 to 50 to fill out an online questionnaire regarding demographic information, anatomical characteristics of the penis, as well as PE and ED. Participants reported their age, penile length, penile circumference, circumcision status, and foreskin characteristics as well as answered the International Index of Erectile Function-5 (IIEF-5) and Checklist for Early Ejaculation Symptoms (CHEES). Penile length and girth were associated with less ejaculatory problems, but only penile length was associated with less erectile problems. Results showed that overall higher age was associated with less ejaculatory and erectile problems. This pattern was confirmed in the younger group (age < = 31) where higher age was associated with less ejaculatory and erectile problems. However, in the older group (age > 31), higher age was associated with more ejaculatory and erectile problems. The relationship between penile length and sexual function did not change with age whereas penile girth was associated with less ejaculatory problems in the older age group only. Male circumcision and less foreskin covering the glans penis were associated with less ejaculatory and erectile problems. The present study is the first study to investigate the association between anatomical characteristics of the penis (penis size and circumcision) and sexual function. However, the self-reported measurement of penis size is a potential limitation. the penis size was measured by self-reported. There is a potential limitation to the reliability of such self-reports. The results indicated that the relationship between the anatomical characteristics of the penis and sexual function was complex. Also, the effects of age on sexual function were positive among younger men and negative among older men.
Geographical Discrepancy in Oral Food Challenge Utilization Based on Canadian Billing Data
Authors: Baba Ala El , Jeimy Samira , Soller Lianne , Kim Harold , Bégin Philippe , Chan Edmond 
Published: November 2022

Abstract
Background: Oral Food Challenges (OFC) confer the highest sensitivity and specificity in diagnosis; however, uptake has been variable across clinical settings. Numerous barriers were identified in literature from inadequate training to resource access. OFC utilization patterns using billing data have not been previously studied.
Objective: The objective of this study is to explore the geographic differences in utilization of OFCs across Ontario and Quebec using anonymized billing data from 2013-2017.
Methods: Anonymized OFC billing data were obtained between 2013-2017 from Ontario Health Insurance Plan (OHIP) and Régie de l'Assurance Maladie du Québec (RAMQ). The number of OFCs was extracted by location, billings, and physician demographics for clinic and hospital-based challenges.
Results: Over the period studied, the number of OFCs increased by 92% and 85% in Ontario clinics and Québec hospitals, respectively. For Ontario hospitals, the number of OFCs increased by 194%. While Quebec performed exclusively hospital-based OFCs, after controlling for the population, the number of OFCs per 100,000 residents annually were similar to Ontario at 50 and 49 OFCs, respectively. The number of OFCs varied across the territory with an annual rate reaching up to 156 OFCs per 100,000 residents in urban regions and as low as 0.1 in regions furthest from city centers.
Conclusion: OFC utilization has steadily increased over the last decade. There has been marked geographical discrepancies in OFC utilization which could be driven by the location of allergists and heterogeneity in their practices. More research is needed to identify barriers and propose solutions to them.
Mycobacterium tuberculosis lineage 4 associated with cavitations and treatment failure
Authors: Ordaz-Vázquez Anabel , Torres-González Pedro , Ferreyra-Reyes Leticia , Canizales-Quintero Sergio , Delgado-Sánchez Guadalupe , García-García Lourdes , Ponce-De-León Alfredo , Sifuentes-Osornio José , Bobadilla-Del-Valle Miriam 
Published: November 2022

Abstract
Background
Mycobacterium tuberculosis genotyping has been crucial to determining the distribution and impact of different families on disease clinical presentation. The aim of the study was to evaluate the associations among sociodemographic and clinical characteristics and M. tuberculosis lineages from patients with pulmonary tuberculosis in Orizaba, Veracruz, Mexico.
Methods
We analyzed data from 755 patients whose isolates were typified by 24-loci mycobacterial interspersed repetitive unit–variable number of tandem repeats (MIRU-VNTR). The associations among patient characteristics and sublineages found were evaluated using logistic regression analysis.
Results
Among M. tuberculosis isolates, 730/755 (96.6%) were assigned to eight sublineages of lineage 4 (Euro-American). Alcohol consumption (adjusted odds ratio [aOR] 1.528, 95% confidence interval (CI) 1.041–2.243; p = 0.030), diabetes mellitus type 2 (aOR 1.625, 95% CI 1.130–2.337; p = 0.009), sputum smear positivity grade (3+) (aOR 2.198, 95% CI 1.524–3.168; p < 0.001) and LAM sublineage isolates (aOR 1.023, 95% CI 1.023–2.333; p = 0.039) were associated with the presence of cavitations. Resistance to at least one drug (aOR 25.763, 95% CI 7.096–93.543; p < 0.001) and having isolates other than Haarlem and LAM sublineages (aOR 6.740, 95% CI 1.704–26.661; p = 0.007) were associated with treatment failure. In a second model, multidrug resistance was associated with treatment failure (aOR 31.497, 95% CI 5.119-193.815; p < 0.001). Having more than 6 years of formal education was not associated with treatment failure.
Conclusions
Knowing M. tuberculosis genetic diversity plays an essential role in disease development and outcomes, and could have important implications for guiding treatment and improving tuberculosis control.
Causal Effects of Red Cell Distribution Width on Rheumatoid Arthritis and Congestive Heart Failure: A Phenome-Wide Mendelian Randomization Study
Authors: Lei Jing , Liu Zhenqiu , Zhao Renjia , Zhu Dongliang , Jiang Yanfeng , Xu Kelin , Zhang Tiejun , Jin Li , Suo Chen , Chen Xingdong 
Published: November 2022

Abstract
The authors have requested that this preprint be removed from Research Square.
Quality of Life in Older Adults, Associated Factors and Its Correlation with Loneliness and Activities of Daily Living
Authors: Rostami Zahra , Abbasian Mehdi , Soleimanpour Hassan , Mortezaei Ali , Sarbazi Ehsan , Ghasemi Masouma , Nemati Mohammad Sadra 
Published: November 2022

Abstract
Background and objective:
Modifying the older adults lifestyle and attention to its quality may greatly increase the older adults efficiency and independence. This paper investigates the factors affecting the older adults quality of life and its relations with activities of daily living and loneliness in the city of Tabriz.
Method
This cross-sectional study was conducted on 315 older adults in the city of Tabriz. Data were collected using the questionnaires including The 12-Item General Health Questionnaire (GHQ-12) with six PCS-related items and six MCS- related items; the 6-item Activities of Daily Living Scale (ADL); and the 6-item De Jong Gierveld Loneliness Scale. Data were analyzed in SPSS 22 software using descriptive statistics and multiple linear regression analysis.
Findings:
In this research, the mean and standard deviation of the summary of the physical component and mental component of quality of life were 49.35 ± 9.45 and 48.38 ± 11.65, respectively. The feeling of loneliness affected MCS, with an inverse significant relationship with the feeling of emotional loneliness (p=-0.38, β = 0.002), and a direct relationship with the feeling of social loneliness (p = 0.031, β = 0.27). Dependent ADL compared to independent ADL had an inverse relationship with PCS (β = -0.23, p < 0.001).
Conclusion
The emergence of restrictions in the living conditions of the older adults, such as loneliness, may have a positive effect on their health instead of a negative effect, especially if they are worried about their health. For this purpose, it is necessary to make plans related to empowerment, activities of daily lifeving, reducing the feeling of loneliness, improving the quality of life of the older adults according to their conditions, and considering the heterogeneity of the older adults.