bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antinociceptive Investigations of Niranthin in Complete Freund’s Adjuvant-
induced Chronic Pain in Mice
Authors: Chopade Atul R. , Salunkhe Vijay R. , Patil Pramod A. , Burade Madhav R. , Somade Prakash M. , Mali Suraj N. , Pandey Anima 
Published: January 2022

Abstract:
The main objectives of the present work are to determine the clinical effect of niranthin
on visceral or somatic inflammatory pain. The study was performed to determine the effects of niranthin
on visceral or somatic inflammatory hypersensitivity of adult Swiss albino mice by using
complete Freund’s adjuvant (CFA) induced pain model. The effect of CFA injection was determined
after 24 hours of injection by using an aesthesiometer such as Von Frey filaments to evaluate
tactile acetone-evoked cooling and thermal sensitivity. We used a digital Plethysmometer to
measure paw edema. Single dose of niranthin intraperitoneal injection (5 and 10 mg/kg) was injected
into mice having CFA-induced mechanical hypersensitivity and after 30 minutes of administration,
reduced mechanical hypersensitivity was observed. In addition, niranthin also reduced acetone-
evoked hypersensitivity within 4 hours. Compared to DMSO, niranthin was most highly active
to reduce CFA-induced paw edema. To reduce mechanical hypersensitivity, multiple doses of
niranthin (bis in die (b.i.d.)) from 1st - 5th day and b.i.d. day 9th and 10th) were given and remarkable
results were observed such as did not cause tolerance in multiple dosing and significantly reduced
in CFA induced hypersensitivity. This work reported niranthin having antinociceptive activity and
indicated that niranthin is conventionally active in the management of persistent pain.
HIV Surveillance and Research for Migrant Populations: Protocol Integrating Respondent-Driven Sampling, Case Finding, and Medicolegal Services for Venezuelans Living in Colombia
Authors: Wirtz Andrea L , Page Kathleen R , Stevenson Megan , Guillén José Rafael , Ortíz Jennifer , López Jhon Jairo , Ramírez Jhon Fredy , Quijano Cindy , Vela Alejandra , Moreno Yessenia , Rigual Francisco , Case James , Hakim Avi J , Hladik Wolfgang , Spiegel Paul B 
Published: January 2022

Background
Epidemiologic research among migrant populations is limited by logistical, methodological, and ethical challenges, but it is necessary for informing public health and humanitarian programming.

Objective
We describe a methodology to estimate HIV prevalence among Venezuelan migrants in Colombia.

Methods
Respondent-driven sampling, a nonprobability sampling method, was selected for attributes of reaching highly networked populations without sampling frames and analytic methods that permit estimation of population parameters. Respondent-driven sampling was modified to permit electronic referral of peers via SMS text messaging and WhatsApp. Participants complete sociobehavioral surveys and rapid HIV and syphilis screening tests with confirmatory testing. HIV treatment is not available for migrants who have entered Colombia through irregular pathways; thus, medicolegal services integrated into posttest counseling provide staff lawyers and legal assistance to participants diagnosed with HIV or syphilis for sustained access to treatment through the national health system. Case finding is integrated into respondent-driven sampling to allow partner referral. This study is implemented by a local community-based organization providing HIV support services and related legal services for Venezuelans in Colombia.

Results
Data collection was launched in 4 cities in July and August 2021. As of November 2021, 3105 of the target 6100 participants were enrolled, with enrollment expected to end by February/March 2022.

Conclusions
Tailored methods that combine community-led efforts with innovations in sampling and linkage to care can aid in advancing health research for migrant and displaced populations. Worldwide trends in displacement and migration underscore the value of improved methods for translation to humanitarian and public health programming.

International Registered Report Identifier (IRRID)
DERR1-10.2196/36026
Heart Score for Predicting in Hospital Major Cardiovascular Event in Patient with Non ST Segment Elevation Acute Coronary Syndrome
Authors: Ilyas Kamal Kharrazi , Kasiman Sutomo , Hasan Harris , Mukhtar Zulfikri , Hasan Refli , Raynaldo Abdul Halim 
Published: January 2022

Background: Acute Coronary Syndrome (ACS) is one of the main problems in the field of cardiovascular diseases because of high hospitalization rate, high mortality and high medical cost. Rapid and accurate risk stratification is needed to calculate the risk of complication and right now exist two most used score which is GRACE and TIMI. Heart score has 5 simple variables that can be calculated easily and this score considered to have better predictive ability compared to other score. The aim of this study is to examine HEART score as a predictor for in hospital Major Cardiovascular Event (MACE) in patient diagnosed as Non ST Segment Elevation Acute Coronary Syndrome (NSTEACS) that hospitalized at Haji Adam Malik (HAM) General Hospital Medan.
Methods: This is a prospective cohort study that includes 52 NSTEACS patient that hospitalized at HAM General Hospital since November 2018 until January 2019. Patient that diagnosed as NSTEACS were calculated for GRACE, TIMI, and HEART score then observed during hospitalization. Outcome of this study is MACE during hospitalization. Statistical analysis was performed to test HEART score as MACE predictor and then comparison was done with GRACE and TIMI
Results: By using ROC curve analysis, the cut-off value of HEART score was 5 (AUC 0.947, 95% CI 0.883-0.997, p<0.01). Study subject that experienced MACE with HEART score ≥5 was 21 patients (87.5%) compared to 2 patients (7.1%). HEART score ≥5 can predict MACE with sensitivity 87.5%, specificity 92.9%, negative predictive value (NPV) 89.7% and positive predictive value (PPV) 91.3%. ROC curve comparison was done between HEART with GRACE and TIMI then it was found that HEART score has better predictive ability compared to TIMI and GRACE (AUC 0.947 vs 0.829 vs 0.807, p < 0.01).
Conclusion: HEART score can be used as MACE predictor which is relatively simpler but have better predictive ability compared to GRACE and TIMI.
Radiation-Induced Heart Disease: From Diagnosis to Prevention
Authors: Budi Yuli Setianto  , Putra Andika 
Published: January 2022

Radiotherapy has become an important component of multimodal treatment of malignancy. After 50 years, there was a drastic increase in outcomes of patients with malignancy. However, improvement of the survival is also accompanied by some inevitable complications on cardiovascular system which are often called radiation-induced heart disease (RIHD). RIHD comprises a spectrum of heart disease including pericardial disease, coronary artery disease, valvular heart disease, conduction system abnormalities, cardiomyopathy, and medium or large vessel vasculopathy. The underlying mechanisms include direct effects on function and structure of the heart, or accelerate development of cardiovascular disease, especially with the presence of previous cardiovascular risk factors. Recent studies have identified non-invasive methods for evaluation of RIHD. Furthermore, potential options preventing or at least attenuating RIHD have been developed. This review provides an overview of pathogenesis, clinical manifestation, diagnosis, management, and prevention of RIDH.
Keywords: malignancy, radiotherapy, radiation - induced heart disease.
FAKTOR-FAKTOR YANG MEMPENGARUHI NILAI PERUSAHAAN DIMODERASI OLEH PERTUMBUHAN LABA PADA PERUSAHAAN PERBANKAN YANG TERCATAT DI BURSA EFEK INDONESIA TAHUN 2015-2019
Authors: Octesy Esty , Mukhzarudfa Mukhzarudfa , Wiralestari Wiralestari 
Published: January 2022

Penelitian ini bertujuan untuk menganalisis pengaruh capital adequasy ratio (CAR), loan to deposit ratio (LDR) dan rasio beban operasional terhadap pendapatan operasional (BOPO) terhadap nilai perusahaan dengan pertumbuhan laba sebagai variabel moderasi.Populasi dari penelitian ini adalah perusahaan perbankan yang terdaftar di Bursa Efek Indonesia (BEI) periode 2015-2019.Pemilihan sampel ini menggunakan metode purposive sampling.Pengujian hipotesis menggunakan analisis regresi linear berganda dan Moderated Regression Analysis (MRA) dengan prosedur statistik menggunakan software SPSS versi 25.
Hasil penelitian menunjukkan capital adequasy ratio (CAR), loan to deposit ratio (LDR) dan rasio beban operasional terhadap pendapatan operasional (BOPO) berpengaruh terhadap nilai perusahaan.Berdasarkan hasil uji interaksi MRA, pertumbuhan laba dapat memoderasi pengaruh capital adequasy ratio (CAR), loan to deposit ratio (LDR) dan rasio beban operasional terhadap pendapatan operasional (BOPO) terhadap nilai perusahaan.
Kata kunci: Capital Adequasy Ratio (CAR), Loan To Deposit Ratio (LDR), Beban Operasional TerhadapPendapatan Operasional (BOPO), Pertumbuhan Laba,Nilai Perusahaan
Water Leakage Detection System Using Arduino
Authors: Tina Juma S. , Kateule Beatrica B. , Luwemba Godfrey W. 
Published: January 2022

Clean water is a scarce resource for the human life and is subject to wastage due to leakage of the distribution pipes in large cities. Water pipe leakage is a big problem around the world of which most of the water distribution authorities faces difficulties to detect the location of the fault. This problem of leakage can be caused by several factors such as breakage of the pipelines due to aging or ongoing constructions in urban cities like Dar es salaam, consequently due to that case, the distribution authorities face hardship to identify the cause and enable them to take action. Therefore, the aim of this project was to develop an IoT-based system for water leakage detection. The prototype was developed comprising two sensors embedded at the source and destination points to measure the flow rate of water. The result indicated that the volume of water generated at the start point can be compared with the other end to determine if there is any leakage. A greater focus on distance calculation could produce interesting findings that account for more research on IoT monitoring systems.
Hurdles in the Access of Regular Dental Care among the Medical & Dental Students of Lahore
Authors: Zahid Omer Bin , Rehman Ajwa , Jamil Hassan , Shoaib Muhammad , Bilal Mehak , Raza Farheen 
Published: January 2022

Introduction: Despite the great leaps in oral health globally, many countries of the world still face a horde of dental problems. Especially poverty ridden populations of the developing nations. Distribution of oral disease varies among different communities and sometimes even in the same community due to various environmental factors, factors of personal hygiene and oral habits among different demographics. However, the condition of oral health in the patients of Lahore is abysmal as determined by various previous dental surveys. The prevalence of cavities in dental patients is 82.3% while the rest of 17.7% have swollen gums, abscess, infection, and pain. Thus, this study aims to test the barriers in the way of regular dental care by evaluating a major portion of medical and dental students by using a cross sectional, questionnaire-based study, and to make regular dental care more accessible to the students of this metropolis.
Objective: To determine the factors that become a hurdle in the way of regular dental care among the medical and dental students of Lahore and to pave the way for further studies on this topic.
Methodology: This survey, after approval from the Internal Review Board of de’Montmorency College of Dentistry, was carried out from July to October 2021. Sample size was calculated using OpenEpi, keeping the confidence level at 95% and the margin of error at 6%. The sampling population included 234 respondents who were randomly selected from 4 different medical and dental colleges of Lahore including both public and private sector colleges. Data was collected using a structured questionnaire titled; Questionnaire for Assessment of Perceived Oral Health Care Needs, Barriers to Accessing Oral Health Care Services and Its Utility8. Statistical analysis was performed using SPSS® version 22.
Result: All of the participants were students of medical and dental colleges of Lahore. More than half of the participants agreed to have not visited a dentist regularly for regular checkups for maintenance of oral health. About 55% of the participants agreed to not visiting a dentist due to fear of infection transmission. We also found a significant association between the stream of education and regular dental visits (p=0.000).
Conclusion: For medical and dental students, the biggest barrier in regular oral healthcare is fear of infection transmission, and unavailability of time. However, fear of dental procedures and high cost of service also play a role. Moreover, the high cost of service is not as strong of a factor as it is for the general population.
Accumulation and Combined Effect of Salinity and Heavy Metals on Growth, Yield and Uptake of Green Pea Grown in Piped Hydroponics
Authors: Haddad M. N. , Al-Jada M. A. 
Published: January 2022

This research is to study the accumulation and combined effect of three salinity levels (750, 1500 and 3750 ppm) and of heavy metals (3.26, 3.2, 2 ppm, 2, and 0.2 of Zn, Cu, Fe, Mn, and Mo, respectively) on growth, yield, and uptake of green pea plants grown in piped hydroponic. Due to freshwater shortages, the use of hydroponic growth system was encouraged and used. The experiment consists of planting green peas from seeds into a 6” PVC piped system. After 2.5 months of growing, the experiment was stopped and plants parts were separated and divided into pods, leaves, stems, and roots, Then, physical, and chemical measurements conducted on them. Results indicated that (1) Salt concentration above 1500 mg/l was detrimental on the growth of green pea, (2) the best growth, yield, and biomass weight were observed at salinity of 750 mg/l, (3) heavy metals had positive effect on stems and roots of plants, but declined effect plant growth in general, (4) lines with nutrient deficiency were deficient in growth too, (5) sodium increased in plant’s organs in response to increased salinity in the feed solution, (6) the largest concentration of copper and zinc were found at the roots of the highest salinity level lines (36.05 and 211.58 mg/kg dry plant, respectively), (7) the hydroponic system proved to be efficient and economical and therefore, it is recommended for use for Palestinian farmers, and (8) results obtained in this study agree with previously published research with extent differences.
PENGALAMAN AYAH DALAM MERAWAT ANAK DENGAN AUTISM SPECTRUM DISORDER (ASD)
Authors: Galih Diessa Restikaning , Oktarianto Muhammad Luthfi 
Published: January 2022

Autism Spectrum Disorder (ASD) merupakan kondisi kesulitan dalam interaksi sosial dan komunikasi pada perkembangan anak yang berlangsung seumur hidup. Pola pengasuhan terhadap anak ini menjadi tantangan tersendiri terhadap orang tua khususnya seorang ayah. Tujuan review ini adalah untuk mengetahui bagaimana pengalaman ayah dalam merawat anak dengan Autism Spectrum Disorder. Penelitian kualitatif ini menggunakan pendekatan studi pustaka. Peneliti menemukan jurnal internasional pada beberapa database yang meliputi Science Direct, Sage Pub, Springer, Elsevier, Tandfonline dan JStor dari tahun 2011-2020. Kegiatan ini meliputi review terhadap jurnal yang membahas mengenai pengalaman ayah dalam merawat anak dengan autism spectrum disorder. Setelah melakukan serangkaian screening ditemukan enam jurnal yang sesuai dengan topic tersebut. Hasil penelitian ini menunjukan bahwa pengalaman merawat anak dengan autism spectrum disorder dapat memperkaya pengalaman, membutuhkan penerimaan dan dukungan lingkungan sekitar untuk mengurangi stressor yang didapatkan. Diperlukan adanya kegiatan untuk memperkaya pemahaman dalam pola pengasuhan anak kepada ayah agar kualitas hidup anak penderita Autism Spektrum Disorder semakin baik.
HUBUNGAN ANTARA CULTURE SHOCK DENGAN PRESTASI BELAJAR PADA MAHASISWA PAPUA TAHUN PERTAMA YANG MERANTAU DI UKSW SALATIGA
Authors: Tekege Elisabeth , Prasetya Berta Esti Ari 
Published: January 2022

Kebudayaan dan lingkungan yang baru membuat individu seperti mahasiswa berada di dalam kondisi yang berbeda dari lingkungan daerahnya, perubahan ini apakah akan mengakibatkan prestasi belajar akan berada pada taraf yang baik atau tidak pada setiap mahasiswa yang merantau. Penelitian ini bertujuan untuk mengetahui hubungan antara culture shock dan prestasi belajar pada mahasiswa tahun pertama yang merantau di UKSW Salatiga. Metode penelitian dalam pengambilan sampel menggunakan teknik snowball sampling dengan melibatkan 102 mahasiswa angkatan 2019 yang berasal dari Papua. Pengambilan data melalui kuesioner yang disebarkan ke setiap responden dengan teknik analisa data menggunakan uji korelasi spearman’s rho dengan bantuan aplikasi SPSS 26.0. Hasil penelitian menunjukkan nilai r = 0.068 (P>0,05) yang berarti tidak adanya hubungan signifikan antara culture shock dengan prestasi belajar. Dengan demikian hipotesis (H1) ditolak dimana hal ini menunjukkan bahwa tidak adanya hubungan yang singnifikan antara culture shock dan prestasi belajar.
Optimization of compatible solutes for improving survival of freeze-dried Lactobacillus delbrueckii subsp. bulgaricus using Box-Behnken design
Authors: Shu Guowei , Li Bohao , Zhang Meng , Huang Jie , Chen Li , Dong Xu 
Published: January 2022

Abstract

Lactobacillus delbrueckii subsp. bulgaricus is widely used in yogurt as a starter. The freeze-drying process may cause bacteria death. In the present work, the effect of three solutes (NaCl, sorbitol, and sodium glutamate) in MRS on viability of L.bulgaricus during freeze-drying was investigated. The optimal combination of adequate solutes was chosen by Box-Behnken Design. The survival rate and viable counts in freeze-dried powder, as well as the viable counts in broth, were used as responses. The results revealed that the optimum combination of solutes in MRS broth were 0.50% NaCl, 0.19% sorbitol, and 0.06% sodium glutamate. Under these optimal conditions, the survival rate was 53.2±0.14%, the viable counts in freeze-dried powder was 8.51±0.23×1010 CFU/g, and the viable counts in broth was 6.05±0.19 ×108 CFU/mL, which were increased by 17.18%, 15.94%, and 17.31%, respectively, compared to the control. This research demonstrated the possibility of viability improvement of L.bulgaricus, which may provide a feasible reference for industrial development.
Cochran’s Q-Test on Soil Helminth Prevalence
Authors: David I. J. , Adehi M. U. , Ikwuoche P. O. 
Published: January 2022

Summary
A study was made of the prevalence of nine geohelminth egg types in 184 soil samples from 16 recreational parks in Abuja metropolis, Nigeria. Cochran’s Q-test was applied to determine whether the difference in the proportions of the egg types found in the soil samples was significant. At a 5% significance level, it was found that the prevalence of the egg types was significantly different in the 184 soil samples from 16 parks. To identify which of the geohelminth eggs had a significantly larger mean proportional prevalence, a minimum required difference mean comparison technique was applied. The mean comparison test showed that Taenia and Coccocidia eggs were highly prevalent, with significantly larger mean proportions than the other analyzed geohelminth eggs in the 184 examined soil samples.
Influence of different sowing density in two varieties of maize. Part II. Relation to agricultural morphological features
Authors: Szulc Piotr , Ambroży-Deręgowska Katarzyna 
Published: January 2022

Summary
In this paper, we investigate the effect of seeding density on several morphological features such as plant height, height of the production ears, ear length, ear diameter, leaf area, and LAI (leaf area index). Inference is based on a series of three-year two-factor experiments with two hybrid maize varieties – SY Cooky and Drim “stay-green” type – and 5 sowing densities: 6, 7, 8, 9 and 10 plants per m2. The “stay-green” maize variety had production cobs significantly higher on the plant, and had a thicker cob and a larger leaf assimilation area than the conventional variety. Increasing maize sowing density from 6 to 10 plants m−2 resulted in a linear decrease in cob length and diameter, while it increased the LAI. Significantly higher chlorophyll content, expressed in SPAD units, was found in the “stay-green” hybrid at the BBCH 67 stage in a wet (2012) and drier year (2014), compared with the traditional variety. This may indicate that such a variety is more tolerant to stress conditions.
Hesitancy Prevalence and Sociocognitive Barriers to Coronavirus Vaccinations in Nigeria
Authors: Oguntayo Rotimi , Olaseni Abayomi O. , Ogundipe Abiodun Emmanuel 
Published: January 2022

Abstract
This study examined the prevalence, socioeconomic and cognitive barriers of coronavirus vaccinations in Nigeria. The study used an ex-post facto design. 526-participants were sampled using snowball sampling technique. A questionnaire pack containing socio-demographics and a 13-item adapted scale of SYKES was used. Findings revealed the prevalence of COVID-19 vaccination hesitancy (61.7%). Adolescents (83.8%) recorded more hesitancy than participants in early-adulthood (62.7%), middle-adulthood (53.1%), and late-adulthood (53%). Males (83.8%) showed hesitancy than the females (33.3%). More so, the primary (62.5%) and secondary school certificate holders (41.4%) scored more on hesitancy than tertiary certificate holders (36.0%). The identified perceived barriers to vaccinations are: safety (91%); government distrust (75.5%) and coerciveness (65.7%), vaccines efficacy (62.5%), complacency (65.7%), and constraints to vaccination center (55.5%). Conclusively, vaccination hesitancy was found more among males and younger respondents. Safety and efficacy of the vaccines, government distrust, coercive approach, and complacency were found as major barriers.
The Impact of the Principal Leadership Style on Teacher Job Satisfaction among Arab Teachers in Israel: A Qualitative Analysis
Authors: Bsoul Tahreer , Vasiluţă-Ștefănescu Marius 
Published: January 2022

Abstract
This study examines the impact of the management and leadership style of a school principal on teachers’ satisfaction in the Arab sector in Israel. The article presents central concepts of the research and the influence of each of the leadership and management styles of principals on teachers’ satisfaction within an Arab school in Israel. Teachers’ satisfaction (the dependent variable) refers to various variables related to teachers’ well-being at school, such as organizational commitment and motivation in the workplace, that are also linked to the teacher satisfaction (Arar & Masri-Herzallah, 2016). Accordingly, these variables are presented with reference to their definition, their impact, and the way they are affected by the management and leadership styles. The research is based on the qualitative methodology, in which we conducted observations in these Arab schools in Israel in and around the Arab city of Nazareth. In these observations, we visited the schools and observed how teachers and principals communicate and whether teachers were satisfied from their interaction with the principal.