bluuebunny/crossref_metadata_2025_split huggingface dataset:
Making decisions under uncertainty: The Prudent Judgement Approach
Authors: Kumar Manali 
Published: May 2022

AbstractThis article offers an alternative conceptualisation of prudence as encompassing four normative components: reflective reasoning, experience, long-term well-being, and moderation. Prudence involves a pattern of reflective reasoning informed by experience in the pursuit of long-term well-being through moderate judgements and actions. This conceptualisation allows distilling a set of prescriptions for guiding deliberation and choice under uncertainty, which I name the Prudent Judgement Approach. An analysis of John F. Kennedy's deliberations at the start of the Cuban Missile Crisis uncovers evidence of prudent judgement and demonstrates the practical feasibility and value of this approach. Although the numerous cognitive and procedural sources of errors in decision-making under uncertainty are by now well understood, there are few prescriptive approaches for guiding the process of formulating judgements and making choices. This article shows how prudence can help improve the quality of deliberative processes and policy choices.
Alliance management and innovation under uncertainty
Authors: Bouncken Ricarda B. , Fredrich Viktor , Gudergan Siegfried 
Published: May 2022

AbstractDrawing on the configuration argument of strategic fit – i.e., an effective alignment of a firm's strategy with its environment, internal structures, and processes – and the resource-based view, this paper clarifies the impact of alliance strategy, alliance management resources, and alliance management capabilities on innovation performance in collaborative ventures. This study of 441 collaborative ventures in the electronics industry offers empirical support for the configuration argument. First, greater alliance strategy formalization influences innovation performance directly and indirectly. Alliance management capabilities – that reflect organizational routines to implement an alliance strategy – partially mediate this effect. Second, alliance management capabilities leverage alliance management resources in that the effect of the former on innovation performance is moderated by the latter. Furthermore, greater innovation strategy formalization affects innovation performance and moderates the direct effect of alliance strategy formalization on innovation performance; an effect that increases with technological uncertainty.
Effects of calving and submarine melting on steady states and stability of buttressed marine ice sheets
Authors: Haseloff Marianne , Sergienko Olga V. 
Published: May 2022

AbstractMass loss from ice shelves is a strong control on grounding-line dynamics. Here we investigate how calving and submarine melt parameterizations affect steady-state grounding-line positions and their stability. Our results indicate that different calving laws with the same melt parameterization result in more diverse steady-state ice-sheet configurations than different melt parameterizations with the same calving law. We show that the backstress at the grounding line depends on the integrated ice-shelf mass flux. Consequently, ice shelves are most sensitive to high melt rates in the vicinity of their grounding lines. For the same shelf-averaged melt rates, different melt parameterizations can lead to very different ice-shelf configurations and grounding-line positions. If the melt rate depends on the slope of the ice-shelf draft, then the positive feedback between increased melting and steepening of the slope can lead to singular melt rates at the ice-shelf front, producing an apparent lower limit of the shelf front thickness as the ice thickness vanishes over a small boundary layer. Our results illustrate that the evolution of marine ice sheets is highly dependent on ice-shelf mass loss mechanisms, and that existing parameterizations can lead to a wide range of modelled grounding-line behaviours.
Milk yield variation partially attributed to blood oxygen-mediated neutrophil activation in lactating dairy goats
Authors: Cai Jie , Liang Shulin , Xie Yunyi , Zang Xinwei , Jiang Luyi , Miao Chao , Liu Jianxin , Wang Diming 
Published: May 2022

AbstractBlood oxygen is an essential component for numerous biological processes of mammalian animals. Milk production of ruminants largely relies on the supply of nutrients, such as glucose, amino acids and fatty acids. To define the regulatory role of blood oxygen availability in regard to milk production, seventy-five healthy Guanzhong dairy goats with similar body weight, days in milk and parities were selected. For each animal, milk yield was recorded and milk sample was collected to determine compositions. Milk vein blood was collected to determine parameters including blood gas, physio-biochemistry and haematology. Another blood sample was prepared for transcriptome and RT-qPCR. Results showed that both pressure of oxygen (pO2) in the milk vein (positively) and numbers of neutrophils in mammary vein (negatively) were associated with milk yield of the animals. To learn the role of pO2 in blood cell functionality, twelve animals (six with higher yield (H-group) and six with lower yield (L-group)) from seventy-five goats were selected. Compared with animals in L-group, goats in H-group were higher in pO2 but lower in pCO2, lactate, lactate dehydrogenase activity and neutrophil abundance in milk vein, compared with L-group. The blood transcriptome analysis suggested that compared with L-group, animals in H-group were depressed in functionality including neutrophil activation and metabolic pathways including glycolysis, NF-κB and HIF-1. Our result revealed that lower milk production could be associated with neutrophil activation responding to low pO2 in the mammary vein. In the meantime, we highlighted the potential importance of blood oxygen as a milk yield regulator.
A poor diet quality is associated with more gas-related symptoms and a decreased quality of life in French adults
Authors: Chaumont Soline , Quinquis Laurent , Monnerie Bénédicte , Six Chloé , Hébel Pascale , Chassany Olivier , Duracinsky Martin , Le Nevé Boris 
Published: May 2022

AbstractThis study evaluated the association between dietary patterns, gas-related symptoms (GRS) and their impact on quality of life (QoL) in a representative sample (n 936) of the French adult population. During the 2018–2019 ‘Comportements et Consommations Alimentaires en France’ survey (Behaviors and Food Consumption in France), online evaluation of GRS in adult participants was performed using the validated Intestinal Gas Questionnaire (IGQ), which captures the perception of GRS and their impact on QoL via six symptom dimensions scores (range 0–100; 100 = worse) and a global score (mean of the sum of the six symptom dimensions scores). Socio-demographics, lifestyle parameters and dietary habits (7-d e-food diary) were also collected online. Quality of diet was determined using the Nutrient-Rich Food 9.3 (NRF9.3) score (range 0–900; 900 = best). Univariate and multivariate linear regression models were applied to identify factors associated with IGQ global score. K-means was used to identify clusters of subjects based on their dietary records. Data from 936 adults who completed both the IGQ and the food diary showed a mean IGQ global score of 11·9 (sd 11·2). Younger age and female sex were associated with a higher IGQ global score. Only 7 % of subjects reported no symptom at all and nearly 30 % of study participants reported a high impact of GRS on their QoL. Two dietary clusters were identified: cluster 1, characterised by a higher consumption of fruits and vegetables, lower sugars intake and higher NRF9.3 score and cluster 2, characterised by higher intake of sugars, lower intake in dietary fibres and lower NRF9.3 score. The IGQ global score was lower in cluster 1 and higher in cluster 2 v. the total sample average (P < 0·001). The prevalence of GRS in the French adult population is high and is associated with impaired QoL and dietary patterns. A change in food habits towards healthier patterns could help reducing the burden of GRS.
Epistemic Perspectives on Enthusiasm in Late Seventeenth-Century England
Authors: Pannese Alessia 
Published: May 2022

AbstractThis study examines the late seventeenth-century reception of enthusiasm in England in the context of the contemporary epistemological debate. Challenging characterizations of responses to enthusiasm as partitioned along the rationalist-empiricist divide, I show how parallel critiques of enthusiasm by natural philosophers and theologians suggest shared epistemic commitments across methodological and disciplinary boundaries, reflecting evolving concerns in the broader epistemological debate, rather than fixed, domain- or ideology-specific positions. By challenging a crude rationalist-empiricist division, this study aligns itself with previous literature, while also departing from it, in that it locates in the critique of enthusiasm a previously under-examined facet of that debate. By showing that both natural philosophers and theologians rejected enthusiasm for its irrationality, this work also sharpens the current understanding of the epistemic significance of enthusiasm, in that it identifies the crux of the critique of enthusiasm in its lack of reason, and not of an empirical foundation.
Reception, context and canonicity: The demonization, normalization and eventual proliferation of G. W. F. Hegel in international relations
Authors: Molloy Seán 
Published: May 2022

AbstractG. W. F. Hegel is one of the most significant philosophers in history yet the reception afforded to him in International Relations (IR) does not compare with his peers, most notably Immanuel Kant. Although by no means absent from IR he cannot be described as a canonical figure. Given his stature in philosophy this comparatively minor interest in Hegel prompts investigation into his failure to enter the pantheon of ‘Great Thinkers’ in IR. The critical-historical investigation of Hegel’s reception in IR undertaken in this article reveals that Hegel, unlike Kant, was cast as an intellectual villain – a blood-soaked Priest of Moloch, whose demonic ideology of state-worship led to the slaughter of the First World War, the rise of the Nazis, and the catastrophe of the Second World War. Condemned by an array of leading intellectuals from John Dewey to Karl Popper, Hegel was side-lined and erased until his work was reconsidered by revisionist scholarship in philosophy and – eventually – in International Relations. From the 1980s, a number of hotly contested, decidedly uncanonical ‘Hegels’ have found expression in IR, from a ‘realist’ Hegel to a postcolonial Hegel. Ultimately, the article argues that the treatment of Hegel reveals that the formation of the IR canons was not an innocent, dispassionate process but rather was imbricated in the great ideological and military conflicts of modernity.
Treaty rigidity and domestic democracy: Functions of and constitutional limits to democratic self-binding
Authors: Hohnerlein Jakob 
Published: May 2022

AbstractInternational treaties create a layer of law that is particularly hard to change: While modern treaties entail significant constraints on domestic law-making, amendments require a new consensus of state parties. This creates a conflict with a core aspect of democratic constitutions: the power of new majorities to revise the laws made by their predecessors. In particular, several obligations of international economic law, namely regulatory stability promises in investment protection treaties, but also criminalization requirements under the UN drug control conventions face critique for overly diminishing domestic policy space. How can democratic constitutions deal with those tensions? One approach that is common in some countries accepts a power to legislate in violation of treaty obligations. But denying treaties the quality as real law in the domestic sphere risks to undermine the benefits of the instrument without truly solving the democracy concerns. Instead, democratic constitutions can be read to entail certain standards for engaging in treaties, namely (i) procedure-related duties to include denunciation clauses and political reform mechanisms in the treaty, and (ii) the need to establish a substantive justification for treaty constraints on future domestic law-making by legitimate aims of international constitutionalism or co-operation.
Emerging trends: General fine-tuning (gft)
Authors: Ward Church Kenneth , Cai Xingyu , Ying Yibiao , Chen Zeyu , Xun Guangxu , Bian Yuchen 
Published: May 2022

AbstractThis paper describes gft (general fine-tuning), a little language for deep nets, introduced at an ACL-2022 tutorial. gft makes deep nets accessible to a broad audience including non-programmers. It is standard practice in many fields to use statistics packages such as R. One should not need to know how to program in order to fit a regression or classification model and to use the model to make predictions for novel inputs. With gft, fine-tuning and inference are similar to fit and predict in regression and classification. gft demystifies deep nets; no one would suggest that regression-like methods are “intelligent.”
Precise Drift Tracking for In Situ Transmission Electron Microscopy via a Thon-Ring Based Sample Position Measurement
Authors: Zhang Fan , Zhang Xiaoben , Jia Zhenghao , Liu Wei 
Published: May 2022

Abstract
Visualizing how a catalyst behaves during chemical reactions using in situ transmission electron microscopy (TEM) is crucial for understanding the activity origin and guiding performance optimization. However, the sample drifts as temperature changes during in situ reaction, which weakens the resolution and stability of TEM imaging, blocks insights into the dynamic details of catalytic reaction. Herein, a Thon-ring based sample position measurement (TSPM) was developed to track the sample height variation during in situ TEM observation. Drifting characteristics for three commercially available nanochips were studied, showing large biases in aspects of shifting modes, expansion heights, as well as the thermal conduction hysteresis during rapid heating. Particularly, utilizing the TSPM method, for the first time, the gas layer thickness inside a gas-cell nanoreactor was precisely determined, which varies with reaction temperature and gas pressure in a linear manner with coefficients of ~8 nm/°C and ~50 nm/mbar, respectively. Following drift prediction of TSPM, fast oxidation kinetics of a Ni particle was tracked in real time for 12 s at 500°C. This TSPM method is expected to facilitate the functionality of automatic target tracing for in situ microscopy applications when feedback to hardware control of the microscope.
Preventing Instabilities and Inducing Controlled, Slow‐Slip in Frictionally Unstable Systems
Authors: Stefanou Ioannis , Tzortzopoulos Georgios 
Published: May 2022

AbstractWe propose a theory for preventing instabilities and inducing controlled, slow‐slip in frictionally unstable systems, such as the Generalized‐Burridge‐Knopoff (GBK) model and seismic fault models. We exploit the dependence of friction on pressure and use it as a backdoor for altering the dynamics of the underlying dynamical system. We use the mathematical Theory of Control and, for the first time, we manage to (a) stabilize and restrict chaos in this kind of systems, (b) guarantee slow frictional dissipation and (c) tune the system toward desirable global asymptotic equilibria of lower energy. Our control approach is robust and does not require exact knowledge of the frictional or elastic behavior of the system. Numerical examples of control are given for a Burridge‐Knopoff system and a strike‐slip fault model obeying rate‐and‐state friction. GBK models are known to present Self‐Organized Critical (SOC) behavior. Therefore, the presented methodology shows an additional example of SOC Control. Even though further developments are necessary before any practical application, we expect our methodology to inspire earthquake mitigation strategies regarding anthropogenic and/or natural seismicity.
A 3D Snapshot of Crustal Breakup Deduced From Seismic Analysis of the Tip of the NW South China Sea
Authors: Chao P. , Manatschal G. , Chenin P. , Zhang C. , Ren J. , Peng X. , Zheng J. 
Published: May 2022

AbstractBased on a high‐resolution seismic reflection data set, we describe and map rift domains at the tip of the V‐shaped NW‐South China Sea (NW‐SCS) Basin. We compare our rift domain map with seismic refraction, magnetic and gravity field data, and previously mapped Continent‐Ocean Boundaries (COB). We also define and map syn‐breakup sedimentary and magmatic sequences across the sediment‐rich NW‐SCS, which enables us to reconstruct the tectono‐stratigraphic evolution of the area. This work enables us to describe and discuss the 3D architecture and nature of the crust at the tip of the NW‐SCS, investigate how extensional and magmatic processes interacted during the breakup, and propose a kinematic model for late rifting, breakup, and finally stalling of the seafloor spreading system. This study provides exceptionally well‐documented insights into the spatial and temporal evolution at the tip of a so‐called “rift propagator,” and enables us to show that breakup in the NW‐SCS may rather correspond to a “retrogrador,” in which the extension zone retreats due to the reorganization of a failing rift system.
Fluid Pressure Changes Recorded by Trace Elements in Quartz
Authors: Raimbourg Hugues , Famin Vincent , Canizarès Aurélien , Le Trong Emmanuel 
Published: May 2022

AbstractFluid pressure is a key parameter in earthquake mechanics, controlling seismic failure and plate coupling in convergent zones. Yet fluid pressure is also extremely difficult to quantify at seismogenic depth, which limits our knowledge of the stress state in accretionary prisms. Here, we show that the geochemical record of exhumed hydrothermal quartz veins may be used to place quantitative bounds on fluid pressure variations in subduction zones. The studied veins come from sediments accreted and exhumed by plate convergence in southwestern Japan. Quartz in veins displays growth rims of contrasted bright blue/dark brown cathodoluminescence (CL) colors, high/low Al concentrations, and low/high fluid inclusion abundance. Because Si‐Al substitution (and charge compensation by Li) strongly depends on the rate of quartz precipitation and Si solubility, Al‐Li concentrations must be sensitive to fluid pressure. This is confirmed by fluid inclusions, the density of which, converted into trapping pressures, record fluid pressure drops by up to ∼70 MPa from CL‐brown, Al‐Li‐poor rims to CL‐blue, Al‐Li‐rich quartz rims. CL‐blue rims grow at a fast rate, high Si supersaturation and low fluid pressure whereas CL‐brown rims grow at a slower pace, lower Si supersaturation, and higher fluid pressure. Quartz trace element chemistry thus offers a promising tool to quantify deep fluid pressure variations and their relationships to earthquakes.
An Experimental Model of Unconfined Bubbly Lava Flows: Importance of Localized Bubble Distribution
Authors: Namiki Atsuko , Lev Einat , Birnbaum Janine , Baur Jasper 
Published: May 2022

AbstractMost lava flows carry bubbles and crystals in suspension. From earlier works, it is known that spherical bubbles increase the effective viscosity while bubbles deformed by rapid flow decrease it. Changes in the spatial distribution of bubbles can lead to variable rheology and flow localization and thus modify the resulting lava flow structure and morphology. To understand the roles of bubble and solid phase crystal distributions, we conducted a series of analog experiments of high bubble fraction suspensions. We poured the analog lava on an inclined slope, observed its shape, calculated the velocity field, and monitored its local thickness. A region of localized rapid flow and low vesicularity, whose thickness is thinner than the surrounding area, develops at the center of the bubbly flows. These features suggest that the locally higher liquid fraction decreases the effective viscosity, increases the fluid density, and accelerates the flow. We also found that a halted particle‐bearing bubbly flow can resume flowing. We interpret this to result from the upward vertical separation of bubbles, which generates a liquid‐rich layer at the bottom of the flow. In our experiment, bubbles are basically spherical and decrease the flow velocity, while our estimate suggests that bubbles in natural lava flows could increase or decrease flow velocity. Downstream decreases in flow velocity stops the bubble deformation and can cause a sudden increase of effective viscosity. The vertical segregation of the liquid phase at the slowed flow front may be a way to generate a cavernous shelly paho’eho’e.
GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2–STAT3 axis
Authors: Zhao Chenggang , Yu Huihan , Fan Xiaoqing , Niu Wanxiang , Fan Junqi , Sun Suling , Gong Meiting , Zhao Bing , Fang Zhiyou , Chen Xueran 
Published: May 2022

AbstractGlioblastoma stem cells (GSCs) are a highly tumorigenic cell subgroup of glioblastoma (GBM). Glycogen synthase kinase 3β (GSK3β) is considered a key hub for promoting malignant phenotypes in GBM. However, the functional relationships between GSK3β and GSCs in GBM are unclear. Here, we found that GSK3β was noted as a substrate for ZDHHC4-mediated palmitoylation at the Cys14 residue, which enhanced GBM temozolomide (TMZ) resistance and GSC self-renewal. Clinically, the expression level of ZDHHC4 was upregulated in GBM, which significantly correlated with tumor grade and poor prognosis. The above phenotypes were based on decreasing p-Ser9 and increasing p-Tyr216 by GSK3β palmitoylation, which further activated the enhancer of the zeste homolog 2 (EZH2)–STAT3 pathway. Notably, STAT3 silencing also inhibited ZDHHC4 expression. This study revealed that GSK3β palmitoylation mediated by ZDHHC4 improved the stemness of TMZ-resistant GBM by activating the EZH2–STAT3 signaling axis, providing a new theoretical basis for further understanding the mechanism of TMZ resistance and recurrence after treatment.
Gas in scattering media absorption spectroscopy as a potential tool in neonatal respiratory care
Authors: Panaviene Jurate , Pacheco Andrea , Schwarz Christoph E. , Grygoryev Konstantin , Andersson-Engels Stefan , Dempsey Eugene M. 
Published: May 2022

Abstract
Gas in scattering media absorption spectroscopy (GASMAS) is a novel optical technology employing near-infrared light. It has a potential use in the medical setting as a monitoring and diagnostic tool by detecting molecular oxygen within gas pockets and thus may be a useful adjunct in respiratory monitoring. GASMAS has potential advantages over other monitoring devices currently used in clinical practice. It is a non-invasive, continuous, non-ionising technology and provides unique information about molecular oxygen content inside the lungs. GASMAS may have a future role in optimising respiratory management of neonates in different clinical scenarios such as monitoring cardiorespiratory transition in the delivery room, assessing surfactant deficiency, and optimising endotracheal tube positioning. This article aims to summarise current evidence exploring GASMAS application in a neonate, discuss possible clinical benefits, and compare with other devices that are currently used in neonatal care.

Impact

This article presents a novel optical technique to measure lung oxygen concentrations that may have important clinical uses.

This review summarises the current literature investigating the concept of optical lung oxygen measurement.

Information from this review can guide researchers in future studies.