bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Application of Machine Learning in the Assessment of Pulmonary Embolism in Patients with Gastrointestinal Cancer
Authors: Lee Sang Hyub , Kim Joo Seong , Kim Kyungdo , Lee Seung-Bo , Kim Kwangsoo , Kim Dongmin , Lee Min Woo , Park Namyoung , Choi Jin Ho , Cho In Rae , Paik Woo Hyun , Lee Jun Kyu , Ryu Ji Kon , Kim Yong-Tae 
Published: May 2022

Abstract
Background: Pulmonary thromboembolism (PTE) is one of the most important complications in cancer patients. Gastrointestinal cancers are at increased risk of PTE. However, there were few studies that predict pulmonary embolism using machine learning (ML) in cancer patients. The purpose of this study was to develop an ML based prediction model for PTE in gastrointestinal cancer patients, and to compare its performance with the conventional model. Methods: In a tertiary hospital, patients who underwent computed tomographic pulmonary angiography (CTPA) were reviewed retrospectively from 2010 to 2020. Demographic and predictor variables including the Wells score and D-dimer were investigated. ML was based on the random forest model. In the model comparison, the area under receiver operating curve (AUROC) was used to evaluate the predictive performance of each model.Results: A total of 446 gastrointestinal cancer patients were analyzed in this study. The overall incidence of PTE was 30.0%. PTE was the most common in pancreatic cancer (47.2%). Compared with the conventional model (AUROC 0.605), the performance of ML model predicting PTE was improved (0.706, P = 0.002) and was further improved with additional input of further demographic factors including age and sex (0.743, P < 0.001). The number of patients classified as requiring CTPA was significantly reduced according to the prediction with ML (1.8% vs 9.4%, P< 0.001).Conclusion: Prediction model based on ML might have advantages to improve the diagnostic performance and reduce the number of CTPA compared to the conventional model for PTE in patients with gastrointestinal cancer.
Two new species of Entoloma (Agaricales, Basidiomycota) from Khyber Pakhtunkhwa, Pakistan.
Authors: Izhar Aiman , USMAN MUHAMMAD , KIRAN MUNAZZA , KHALID ABDUL NASIR 
Published: May 2022

Abstract
Cedar towering forests of Kumrat valley, Khyber Pakhtunkhwa, Pakistan were visited to collect mushrooms during several fungal forays, which revealed two interesting and novel species from genus Entoloma, subgenus Cyanula, both are characterized by clamp-less hyphae and bluish-violaceous tinges on their pilei and stipes. Entoloma kumraticus is characterized by its bluish brown centrally depressed pileus, serrulate lamellar edge, bluish violet fibrillose stipe, dense clusters of cheilocystidia and presence of abundant greyish brown intracellular pigments in terminal cells of pileipellis and in few cheilocystidia. The key characters of Entoloma swatica are light brownish olive pileus with violet-blue finely fibrillose covering, translucently striated with radial stripes, blackish brown lamellar edge with clusters of cheilocystidia which are often septate and scaly, fibrillose slightly twisted violet blue stipe. Both new species are described and illustrated here, based on morphological and molecular evidence. E. kumraticus and E. swatica formed distinct phylogenetic lineages based on the sequences of nuclear ribosomal ITS and LSU gene regions.
Acupuncture effects on dogs with Intervertebral Disk Disease: A Pilot Study
Authors: Sawamura Megumi , Arai Toshiro , Kawasumi Koh 
Published: May 2022

Abstract
Sixteen dogs with intervertebral disk disease (IVDD)(3–16 years old) were examined acupuncture effects of energy metabolism changes. Acupuncture treatments were performed at acupuncture points according to individual needs to the dogs. Acupuncture effects were evaluated based on the IVDD evaluation scales. Pyruvate and lactate concentrations, LDH and MDH activities, malate dehydrogenase/lactate dehydrogenase ratio (M/L ratio), and LDH isozyme electrophoretic patterns were measured as energy metabolism markers after the acupuncture treatments. In dogs with IVDD improved group, plasma pyruvate concentrations, LDH and MDH activities were significantly decreased, and M/L ratio were significantly increased. Plasma LDH isozyme electrophoretic patterns changed from LDH5 predominance to LDH1 predominance. The present study suggests that local redox potential is improved and energy metabolisms are activated in dogs with IVDD after the acupuncture treatments. Acupuncture treatments on dogs with IVDD may result in activation of citric acid cycle and increase in ATP production followed by improvement of IVDD. Further studies with a large number of dogs will be needed to clarify this hypothesis.
Three new genera, two new species and one new combination of family Hystrignathidae (Nematoda: Thelastomatoidea) from Ceracupes fronticornis (Westwood) (Insecta: Passalidae) in China
Authors: ZHANG NINGNING , ZHANG LUPING 
Published: May 2022

Abstract
Two new genera and two new species of family Hystrignathidae were collected from Ceracupes fronticornis (Westwood) from the Yunnan Province, China. Pseudoxyo yunnanensis gen. et sp. nov. differs from the related genera by having the cervical region armed with alternating rows of spines, with 22 spines in the first row, and by lacking the first cephalic annule. Sinospinata chitwoodi gen. et sp. nov. can be easily distinguished from the related genera by having the cervical region of females armed with irregularly arranged spines, two or three spines clustered together in their roots in some spines. Meanwhile, Huntinema gen. nov. was proposed to replace Huntia Zhang, Yin, Carreno & Zhang, 2021 because the name of this genus was preoccupied by Huntia Gray & Thompson, 2001 for placement of two new species of spiders. In addition, the 18S and 28S rDNA partial sequences of two new species were obtained.
Light-induced Chiral Self-assembly of Achiral Triphenylamines with Controlled Number of Hydrogen Bondings
Authors: Kim Donghwi , Kim Taehyoung , Kim Youngjun , Kim Woo Youn , Seo Myungeun , Lee Haeshin , Kim Sang Youl 
Published: May 2022

Abstract
We report the self-assembly of achiral triphenylamine molecules with different numbers of hydrogen bonding sites. The supramolecular chirality was controlled by the symmetry breaking effect of circularly polarized light (CPL) occurring in the nucleation step. As the number of hydrogen bonding sites increased, the stability of supramolecular helices increased, and reversible transformation of the right- and left-handed helices by CPL became feasible only with aid of ultra-sonication. In contrast, triphenylamine molecules without hydrogen bonding sites did not undergo light-induced self-assembly.
In-Silico Investigation of Inhibiting Property of Phytoconstituents of Medicinal Herb ‘Aconitum Heterophyllum’ Against Omicron Variant of SARS-CoV-2
Authors: Lakhera Shradha , Devlal Kamal , Rana Meenakshi , Ghosh Arabinda 
Published: May 2022

Abstract
Omicron’s traces have been found significantly faster than the Delta variant. Persons who already have been vaccinated are also affected by this variant. This shows that vaccines taken to combat COVID-19 are less effective in preventing the Omicron’s transmission. Thus, the identification of effective candidates to fight against Omicron has been the top priority in pharmaceutics. The present study deals with the investigation of the antiviral activities of the phytocompounds of Aconitum heterophyllum against the Omicron variant. The systematic in-silico study done in the paper reveals the good binding of Isoatisine with spike glycoprotein of Omicron. Isoatisine molecule follows most of the pharmacokinetic properties that make it a better drug-like molecule. The computed global reactivity parameters fairly justified the high reactivity of the Isoatisine molecule. This study aims to discover the novel antiviral activity of Isoatisine to counter the Omicron protein. The results of this study can also be considered for experimental validation and clinical trials.
Incidence, mortality, and survival analyses for carcinosarcoma from 1975 to 2018: an epidemiological study
Authors: Liu Lin , Zhu Yaqing , Zhou Cuiling , Tian Yun 
Published: May 2022

Abstract
Introduction
Carcinosarcoma (CS) is a rare malignant tumor. Little is known about the epidemiological feature of the disease in literature. Our aim is to offer the largest and latest analysis of the incidence, mortality, and survival of CS.
Methods
Data of CS from the Surveillance, Epidemiology, and End Results (SEER) database (SEER-9 incidence database and SEER-9 incidence-based mortality database) were adopted. Incidence, mortality, and survival analyses were performed by SEER*Stat software. We used annual percentage change (APC) to evaluate the trends in incidence and mortality.
Results
Incidence rate increased from 0.36/100,000 to 0.83/100,000 with an APC of 3.4% from 1975 to 2018. Mortality rate followed a similar pattern of increase at an APC of 3.2% from 0.07/100,000 in 1975 to 0.54/100,000 in 2018. Most CS occurred in the female genital system and the 5-year survival rate of all patients was 34.9%.
Conclusion
CS is an aggressive tumor with increasing incidence and mortality trends. This tumor, especially CS in the female genital system, is no longer considered to be a rare tumor in the near future. This research will broad our knowledge for CS as well as provide insight for clinicians.
Initiation and Rapid Titration of Methadone and Slow-Release Oral Morphine (SROM) in an Acute Care, Inpatient Setting: A Case Series
Authors: Rodger Laura , Nader Maya , Turner Suzanne , Lurie Erin 
Published: May 2022

Abstract
Background: Methadone titration in an outpatient setting typically involves initiation with subtherapeutic doses with slow titration to mitigate the risks of respiratory depression and overdose. In pregnancy, subtherapeutic doses of methadone and slow titrations are associated with poorer outcomes in terms of retreatment retention and ongoing illicit opioid use. We aim to describe rapid titration of OAT in an inpatient setting for pregnant injection opioid users with high opioid tolerance secondary to a fentanyl-based illicit drug supply. Methods: Retrospective case series of patients admitted to a tertiary center with a primary indication of opiate withdrawal and treatment for severe opioid use disorder in pregnancy. Results: Twelve women received rapid methadone titrations with or without slow-release oral morphine for opioid use disorder during a total of fifteen hospital admissions. All women included in the study were active fentanyl users (12/12). Methadone dosing was increased rapidly with no adverse events with a median dose at day 7 of 65mg (IQR 60-70mg) and median discharge dose of 85mg (IQR 70-92.5mg). Slow-release oral morphine was used in half of the titration admissions (8/15) with a median dose of 340mg (IQR 187.5-425mg) at discharge. The median length of admission was 12 days (IQR 9.5-15). Conclusions: A rapid titration of methadone was completed in an inpatient setting with or without slow-release oral morphine, without adverse events showing feasibility of this protocol for a pregnant population in an inpatient setting. Patients achieved therapeutic doses of methadone (and/or SROM) faster than outpatient counterparts with no adverse events.
Nitrogen and carbon stable isotope ratios analysis sheds light on trophic competition between two syntopic land iguana species from Galápagos
Authors: Gargano Marco , Colosimo Giuliano , Gratton Paolo , Marta Silvio , Brilli Mauro , Giustini Francesca , Sevilla Christian , Gentile Gabriele 
Published: May 2022

Abstract
Coexistence between closely related species can lead to intense competition for resources. Stable isotope ratio analysis (SIRA) is a reliable tool to estimate the extent of species competition. We performed SIRA to assess niche partitioning among two syntopic species of Galápagos land iguanas: Conolophus subcristatus and the critically endangered C. marthae. We collected samples from 60 C. marthae and 58 C. subcristatus within an area of about 2 km2 on Wolf Volcano, Isabela Island, where C. marthae is endemic. We determined δ13C and δ15N ratios and described the isotopic niche of each species using corrected standard ellipse area (SEAc). We tested for differentiation between the isotopic niches, while controlling for sex, using bivariate linear models. Despite the extensive overlap of the isotopic niches, our results indicate the existence of niche partitioning mechanisms acting between species and sexes. Evaluating the effect of ecological variables, we found that body size and productivity at the capture points, plus further, undetermined spatial effects explain ca. 75% of the differences observed between species and sexes, providing evidence for differential microhabitat and food-items usage. Our study provides essential baselines for evaluating conservation actions for C. marthae, such as the potential translocation to a sanctuary area.
Multifunctional Logic Gates based on Resonant Transmission at Atomic-Plasmonic structure
Authors: MOSLEH M. , HAMIDI S. M. , RANJBARAN M. 
Published: May 2022

Abstract
Regarding confinement of light at nanoscale dimensions in plasmonic structures, we try to show the impact of hot atomic vapor spectroscopy in a miniaturized scale. In such a combined structure, resonant coupling of atom to plasmonic mode provides diverse ways to control the optical response of the system. We fabricate an atomic plasmonic cell based on Rubidium atomic vapor and gold plasmonic thin film onto Krestchman setup to introduce resonant coupling (EIT-like) of atom- plasmons as a tunable all optical bandpass filter, switch or logic gates. These all-optical devices such as as NOR and XNOR logic gates well done based on the filter by incidence angle of light, temperature as well as external magnetic field. We believe the possibility of easy modulation of atomic susceptibility, not only through direct alteration on atoms but also through common methods available for modulation of plasmonic mode, has the potential to design and fabricate modern all-optical devices.
Multi-Temperature Experiments to Ease Analysis of Heterogeneous Binder Solutions by Surface Plasmon Resonance Biosensing
Authors: Gaudreault Jimmy , Durocher Yves , Henry Olivier , De Crescenzo Gregory 
Published: May 2022

Abstract
SPR biosensing is a well-established tool for the investigation of binding kinetics between a soluble species and an immobilized (bio)molecule. While robust and accurate data analysis techniques are readily available for single species, methods to exploit data collected with a solution containing multiple interactants are scarce. In a previous study, our group proposed two data analysis algorithms for 1) the precise and reliable identification of the kinetic parameters of N interactants present at different ratios in N mixtures and 2) the estimation of the composition of a given mixture, assuming that the kinetic parameters and the total concentration of all interactants are known. Here, we extend the first algorithm by reducing the number of necessary mixtures. This is achieved by conducting experiments at different temperatures. Through the Van’t Hoff and Eyring equations, identifying the kinetic and thermodynamic parameters of N binders becomes possible with M mixtures with M comprised between 2 and N and at least N/M temperatures. The second algorithm is improved by adding the total analyte concentration as a supplementary variable to be identified in an optimization routine. We validated our analysis framework experimentally with a system consisting of mixtures of low molecular weight drugs, each competing to bind to an immobilized protein. We believe that the analysis of mixtures and composition estimation could pave the way for SPR biosensing to become a bioprocess monitoring tool, on top of expanding its already substantial role in drug discovery and development.
Systematic review of Plasmodium knowlesi in Indonesia: a risk of emergence in the context of capital relocation to Borneo?
Authors: Said Ibrahim Bin , Kouakou Yobouet Ines , Omorou Roukayatou , Bienvenu Anne-Lise , Ahmed Kamruddin , Culleton Richard , Picot Stephane 
Published: May 2022

Abstract
Background
The Indonesian Republic plans to relocate its capital from Jakarta to East Kalimantan, Borneo Island in the next few years. This relocation may be associated with deforestation, decreased biodiversity and an increased risk of emerging zoonotic infections including Plasmodium knowlesi malaria. The Malaysian part of Borneo Island is one of the main hotspots of knowlesi malaria.
Methods
Considering this risk, evaluate the transmission dynamics of P. knowlesi in the Indonesian Archipelago based on a literature search and extensive review of data from the Indonesian Ministry of Health.
Results
We report that 545 knowlesi cases were documented in Indonesia, mainly in the Aceh and North Sumatra provinces, with 95% of these occurring in the last four years.
Conclusions
The main P. knowlesi vectors are present in the area of the future capital requiring strengthened surveillance to reduce the risk of emerging cases in a rapidly growing population.
Skin Landmarks as Ideal Entry Points for Ventricular Drainage, a Radiological Study
Authors: ROBLOT Paul , LEFEVRE Etienne , DAVID Romain , PARDO Pier-Luka , MONGARDI Lorenzo , DENAT Laurent , TOURDIAS Thomas , LIGUORO Dominique , JECKO Vincent 
Published: May 2022

Abstract
PURPOSE: Ventricular drainage remains a challenging procedure for neurosurgical trainees, particularly in healthy subjects. The objective of the study was to describe reliable skin landmarks for ideal entry points (IEPs) to catheterize brain ventricles via frontal and parieto-occipital approaches.METHODS: We included 30 healthy subjects who underwent brain MRI and simulated the ideal catheterization trajectories of lateral ventricles using anterior and posterior approaches and localized skin surface IEPs. The optimal frontal target was the interventricular foramen and that for the parieto-occipital approach was the atrium. We measured the distances between these IEPs and easily identifiable skin landmarks.RESULTS: The frontal IEP was localized to 114.00 ± 6.75 mm behind the nasion on the sagittal plane and to 40.04 ± 3.07 mm lateral to the midline on the coronal plane. The ideal catheter length was estimated to be 73.08 ± 4.03 mm from the skin surface to the interventricular foramen. The parieto-occipital IEP point was localized to 61.40 ± 4.44 mm above the ipsilateral tragus on the coronal plane and to 56.53 ± 6.86 mm behind the tragus on the axial plane. The ideal catheter length was estimated to be 51.65 ± 2.86 mm.CONCLUSION: The IEP for the frontal approach was localized to 11 cm above the nasion and 4 cm lateral to the midline. The IEP for the parieto-occipital approach was 5.5 cm behind and 6 cm above the tragus. These measurements differ from the classical descriptions of Kocher’s point and Keen’s point and seem relevant to neurosurgical practice.
Successful DNA amplification of DNA from non-destructive buccal swabbing in Vespertilionid and Rhinolophid bats
Authors: Hughes Morgan , Brown Scott K , Martin Rémi , Young Christopher H , Maddock Simon 
Published: May 2022

Abstract
Acquiring DNA from wild bats (Mammalia: Chiroptera) is typically undertaken utilizing highly invasive (but non-lethal) sampling techniques comprising wing biopsies and occasional blood samples. While non-invasive sampling is possible through the extraction of DNA from faecal samples, it is not always possible to acquire samples from individual bats whilst conducting fieldwork, and as such, this method is primarily applicable to roost occupancy identification. Similarly, wing swabbing is liable to cross-contamination from roost mates. Here we present the first use of oral (buccal) swabbing for successful, species-resolution DNA sequencing of Vespertilionidae and Rhinolophidae in 10 bat species (nine Vespertilionidae and one Rhinolophidae) from the UK.
Massive Renal Oncocytoma ; Case report from Ireland
Authors: ahmed farah 
Published: May 2022

Abstract
Renal oncocytomas are rare and are often incidental findings discovered following check-ups for other non-urological illnesses. A 67 years old male presented to the urology service, in 2019 at Galway University, Ireland with a history of atonic bladder symptoms. Upon investigation he was found to have an incidental mass. Radiological imaging demonstrated a 19cm solid mass in the right kidney weighing 1935 grams. It was large enough to case compression of the surrounding viscera and blood vessels. A Nephrectomy was performed and the diagnosis of oncocytoma was confirmed by histolopathology.
A novel analytical heat source model for cold rolling based on the energy method and unified yield criterion
Authors: Zhang Yufeng , Li Xu , Zhao Meiying , Qu Fuquan , Zhang Yuhe , Peng Wen , Zhao Dewen , Di Hong Shuang , Zhang Dianhua 
Published: May 2022

Abstract
Accurate calculation of the heat source in the roll gap during the cold rolling process is the basis for a well-designed coolant system, which is particularly important for reducing roll wear and improving the flatness quality of strip steel. Although many established numerical models have high precision in calculating the work roll temperature, complex modeling processes and large calculation times result in the inability to predict work roll temperature quickly for the application of automatic control systems. Therefore, the authors develop a new analytical heat source model to calculate the axial temperature distribution of the work roll in the cold rolling process. First, according to the deformation characteristics of strip cold rolling, the deformation zone is divided into a plastic zone and two elastic zones, and the length of each deformation zone is calculated considering the effect of tension. Then friction heat generated in the elastic zone is calculated. Second, new exponential velocity and corresponding strain-rate fields satisfying kinematically admissible conditions are proposed to calculate the deformation heat and friction heat generated in the plastic zone. Finally, the work roll temperature prediction model is established by contemplating the heat source of the roll gap, emulsion heat transfer, air cooling, and contact heat transfer with the intermediate roll. By repeatedly optimizing the weighted coefficient d of intermediate principal shear stress on the yield criterion, the maximum error between the calculated results and the actual measured cold roll temperature data is reduced to 3.1%. Then, the effects of the reduction ratio, rolling speed, and resistance to deformation on the deformation heat and friction heat are discussed. And the variation of temperature field of the work roll with time is analyzed quantitatively.