bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mammography-based determination of breast density and its implications for breast cancer risk in Saudi Arabia
Authors: Almuhanna Afnan F. , Alqowiez Roaa , Almulhim Fatma , Alshamlan Reem , Alnaimi somyyah Ibrahim , Alzuabi Reem Saad , Alshmas Hajar Ibrahim , Awary Khaled Bassam 
Published: April 2022

Abstract
BACKGROUND: Breast cancer is the most commonly diagnosed malignancy in women worldwide. Mammography is the best screening method for the early detection of breast cancer in asymptomatic women; however, its results are associated with high false positive/negative rates. One factor that decreases the sensitivity of mammography-based diagnosis of breast cancer is breast density. This study aimed to identify the association between mammographically determined breast density and breast cancer.METHODS: This single-center retrospective study included 2158 female participants in the Eastern Province of Saudi Arabia who underwent mammography between 2016 and 2018. We evaluated baseline information on breast density and its relationship with breast cancer risk and other factors (age, age at first childbirth, menopause status, and family breast cancer history). Mammogram reports were categorized using the Breast Imaging Reporting and Data System lexicon. RESULTS: The majority (39%) of participants showed scattered fibroglandular density and Breast Imaging Reporting and Data System category 2 (62.5%), while the occurrence of extremely dense breasts was low (4.7%). Breast density was found to be associated with age and menopause status (p < 0.0005). Participants with Breast Imaging Reporting and Data System assessment categories 4 (suspicious for malignancy) and 5 (highly suggestive of malignancy) were associated with elevated breast cancer risk (confirmed by biopsy).CONCLUSION: Breast density was not found to be associated with breast cancer risk in this study. However, the proportion of participants with extremely dense breasts was very low (4.7%). Therefore, further studies are warranted with larger sample sizes including extremely dense breasts.
WITHDRAWN: Effectiveness of transcranial magnetic stimulation in the management of oncological and non-oncological neuropathic pain. A systematic review
Authors: Muñeton Catalina Lopera , Bedoya Silvia Patricia betancur , Bustos Isabel Cristina Angel , Montoya María Guadalupe Vásquez , Toro Sebastián Grajales , Mesa Dionis Vallejo 
Published: April 2022

Abstract
Purpose: Transcranial Magnetic Stimulation (rTMS) emerges as an innovative alternative for the management of neuropathic pain, rTMS is a non-invasive brain stimulation technique which induces electrical currents in the nervous tissue of the cortex. The objective of this study was to evaluate the effectiveness of rTMS in the management of oncological and non- oncological neuropathic pain. Methods: The search was performed in CENTRAL, MEDLINE, Embase, PsycINFO, SCOPUS and LILACS. Inclusion criteria were 1) population: Male and female between 18 and 85 years with oncologic and non-oncologic neuropathic pain; 2) intervention: Treated with Transcranial magnetic stimulation; 3) comparison: Inactive control groups, and parallel active interventions; and 4) outcome: Primary outcome was modulation of pain. Secondary outcomes were quality of life and adverse effects. Risk of bias and quality of study reporting were also assessed. Results: The search found 1116 articles, with 18 articles meeting the PICO criteria. 9 ECAS and 9 observational studies. The total sample was 707 patients, the number of sessions ranges from a single session to 15 sessions, with an average of 3.5 sessions. Follow-up was variable. The Follow-up vary from 7 to 311.8 days, with an average of 45 days. Pain reduction was obtained in the 18 studies. Conclusion: rTMS may be and effective therapeutic option to treat neuropathic pain. We found moderate quality of evidence for pain modulation; for quality of life the results are uncertain to determine changes, due to very low evidence. Additional research effort is needed to reduce bias and improve quality.
Varying severity of symptoms underline the relevance of personalized follow-up care in breast cancer survivors: Latent class cluster analyses in a cross-sectional cohort
Authors: de Ligt Kelly M. , de Rooij Belle H. , Walraven Iris , Heins Marianne J. , Verloop Janneke , Siesling Sabine , Korevaar Joke C , de Poll-Franse Lonneke V. van 
Published: April 2022

Abstract
Purpose
Insights into the severity of co-existing symptoms can help identifying breast cancer survivors in need of symptom management. We aimed to identify subgroups of breast cancer survivors based on patterns of symptom severity, and characteristics associated with these subgroups.
Methods
We selected surgically-treated stage I-III breast cancer survivors 1–5 years post-diagnosis from the Netherlands Cancer Registry (N = 876). We assessed experienced severity of fatigue, nausea, pain, dyspnea, insomnia, appetite, constipation, diarrhea, and emotional and cognitive symptoms through the EORTC-QLQ-C30 Quality of Life Questionnaire on a scale 0-100. We determined subgroups of survivors using Latent class Cluster Analyses (LCA) based on severity of co-existing symptoms and compared their mean severity to the age-matched female reference population to interpret clinical relevance. We assessed subgroup characteristics by multinomial logistic regression analyses.
Results
From 404 respondents (46%), three subgroups of survivors with distinct symptom severity were identified: low severity (n = 116, 28.7%), intermediate severity (n = 224, 55.4%), and high severity (n = 59, 14.6%). The low subgroup reported lower symptom severity than the general population; the intermediate subgroup reported a similar symptom severity, although scores for fatigue, insomnia, and cognitive symptoms were worse (small-medium clinical relevance). The high subgroup had worse symptom severity (medium-large clinical relevance). Compared to the intermediate subgroup, one (RRR:2.75; CI:1.22–6.19; p = 0.015) or more (RRR:9.19; CI:3.70–22.8; p = < 0.001) comorbidities were significantly associated with the high subgroup. We found no associated treatment characteristics.
Conclusion
We identified distinct subgroups of breast cancer survivors based on symptom severity, underlining the relevance of further exploring personalized follow-up strategies.
MarineMetagenomeDB: a public repository for curated and standardized metadata for marine metagenomes
Authors: Rocha Ulisses Nunes da , Nata’ala Muhammad Kabiru , Santos Anderson Paulo Avila , Kasmanas Jonas Coelho , Bartholomäus Alexander , Saraiva João Pedro , Silva Sandra Godinho , Keller-Costa Tina , Costa Rodrigo , de Carvalho André Carlos Ponce de Leon Ferreira , Stadler Peter F. , Sanches Danilo Sipoli 
Published: April 2022

Abstract
BackgroundMetagenomics is an expanding field within microbial ecology, microbiology, and related disciplines. The number of metagenomes deposited in major public repositories such as Sequence Read Archive (SRA) and Metagenomic Rapid Annotations using Subsystems Technology (MG-RAST) is rising exponentially. However, data mining and interpretation can be challenging due to mis-annotated and misleading entries of metadata. In this study, we describe the Marine Metagenome Metadata Database (MarineMetagenomeDB) to help researchers identify marine metagenomes of interest for re-analysis and meta-analysis. To this end, we have manually curated the associated metadata of several thousands of microbial metagenomes currently deposited at SRA and MG-RAST.ResultsIn total, 125 terms were curated according to 17 different classes (e.g., biome, material, oceanic zone, geographic feature, oceanographic phenomena). Other standardized features include sample attributes (e.g., salinity, depth), sample location (e.g., latitude, longitude), and sequencing features (e.g., sequencing platform, sequence count). MarineMetagenomeDB version 1.0 contains 11,449 marine metagenomes from SRA and MG-RAST distributed across all oceans and several seas. Most of the samples were sequenced using Illumina sequencing technology (84.33%). More than 55%of the samples were collected from the Pacific and the Atlantic Oceans. About 40% of the samples had their biomes assigned as ‘ocean’. The ‘Quick Search’ and ‘Advanced Search’ tabs allow users to use different filters to select samples of interest dynamically in the web app. The interactive map allows the visualization of samples based on their location on the world map. The web app is also equipped with a novel download tool (on both Windows and Linux operating systems), that allow easy download of raw sequence data of selected samples from their respective repositories. We demonstrated how users may use the MarineMetagenomeDB web app to select estuarine metagenomes for large-scale microbial biogeography studies quickly.ConclusionThe MarineMetagenomeDB is a powerful resource for non-bioinformaticians to find marine metagenome samples with curated metadata and stimulate meta-studies involving marine microbiomes. Our user-friendly web app is publicly available at https://webapp.ufz.de/marmdb/.
The possibility of angiogenesis inhibition in cutaneous melanoma by Bevacizumab-loaded lipid-chitosan nanoparticle
Authors: Abdi fershteh , Arkan Elham , Eidizadeh Mojtaba , Valipour Elahe , Naseriyeh Tahereh , Gamizgy Younes Hossainy , Mansouri Kamran 
Published: April 2022

Abstract
Cutaneous malignant melanoma is fastest-growing cancer in white populations with a large majority of dermal cancer death. The activity of vascular endothelial growth factors (VEGFs) results in the signaling of a variety of downstream intracellular pathways that ultimately leads to cell activation, proliferation, migration, and angiogenesis. VEGF inhibitors such as Bevacizumab are widely used in chemotherapy with systemic administration, which in many cases is associated with a variety of side effects. Here, we designed and synthesized a lipid-polymer nanoparticle for local administration of Bevacizumab. Drug release, dermal absorption, and the effects of synthesized nanoparticles containing Bevacizumab on cell proliferation and in vitro and in vivo angiogenesis were investigated. Encapsulating Bevacizumab in the synthesized nanoparticles resulted in a significant increase in its dermal absorption compared to free Bevacizumab. Also, the suppressor effects of Bevacizumab encapsulated in the synthesized nanoparticle on cell proliferation and angiogenesis were significantly more than those of free Bevacizumab. Our findings indicate the remarkable effects of lipid-polymer nanoparticles in dermal absorption and in maintaining Bevacizumab bioactivity, suggesting therapeutic benefits of local Bevacizumab administration for angiogenesis-related disorders such as cutaneous melanoma.
Effects of ICT hardware, software and FDI on CO2 emissions in China
Authors: Chi Fangyuan , Meng Zhuo 
Published: April 2022

Abstract
With the rapid development of information and communication technology (ICT) and counter-cyclical expanding of foreign direct investment (FDI), most foreign-invested companies in China are highly polluting. Meanwhile, new research shows that the impact of ICT on the environment is uncertain. This study is an effort in dividing ICT into hardware and software, aiming to explore its effects on CO2 emissions from 2003 to 2017 in 31 provinces, autonomous regions and municipalities in China, and further explore the impacts of its application to foreign-invested enterprises on environmental quality. The findings show that ICT software specifies negative and statistically significant effects on CO2 emissions, but ICT hardware and FDI indicate positive and statistically significant effects on CO2 emissions. However, when ICT software and hardware are applied to foreign-invested enterprises, they can significantly improve the environmental quality. It is noteworthy that previous period of ICT software will increase current CO2 emissions significantly, yet ICT hardware lagged three years will reduce current CO2 emissions significantly.
Third primary SARS-CoV-2 prophylactic mRNA vaccines enhances antibody responses in the majority of patients with haematological malignancies: Results from the MARCH study
Authors: Cook Lucy , O'Dell Gillian , Vourvou Eleni , Palanicawandar Renuka , Marks Sasha , Milojkovic Dragana , Apperley Jane , Loaiza Sandra , Claudiani Simone , Bua Marco , Hockings Catherine , MacDonald Donald , Chaidos Aristeidis , Pavlu Jiri , Cooper Nichola , Fidler Sarah , Randell Paul , Innes Andrew 
Published: April 2022

Abstract
SARS-CoV-2 infection, and resulting disease, COVID-19, has a high mortality amongst patients with haematological malignancies. Global vaccine rollouts have successfully reduced hospitalisations and deaths, but the efficacy of vaccination in patients with haematological malignancies is known to be reduced. The UK-strategy offered a third, mRNA-based, vaccine as an extension to the primary course in these patients. Here we quantify serological responses following these vaccines in a cohort of 381 patients with haematological malignancies attending routine haematology outpatient clinics. By comparison with healthy controls, we report suboptimal responses following two primary vaccines, with significantly enhanced responses following the third primary dose. These responses however are heterogeneous and determined by haematological malignancy sub-type and therapy. We identify a group of patients with continued sub-optimal vaccine responses who may benefit from additional doses, as well as early intervention with monoclonal therapies in the event of developing SARS-CoV-2 infection.
Simultaneous determination of benzothiazoles, benzotriazoles and benzotriazole UV absorbers by solid-phase extraction-gas chromatography-mass spectrometry
Authors: Zhao Mingliang , Chen Yan , Yang Guipeng , Chen Rong 
Published: April 2022

Abstract
This paper proposes a new method for the simultaneous determination of emerging contaminants (ECS) in the marine environment by solid-phase extraction (SPE)-gas chromatography-mass spectrometry (GC-MS). Organic corrosion inhibitors (OCI) and UV absorbers are common products in plastic rubber and personal care products, and they have been acknowledged as emerging contaminants due to their toxicity and bio-accumulative effects in the environment. In addition to common persistent organic pollutants (POPs), it is also necessary to detect and analyze the concentration and composition of these emerging organic contaminants in the ocean. Solid-phase extraction (SPE) and solid-phase microextraction (SPME) were used as two common pretreatment methods. After comparing their recoveries, SPE was used for treatment, and the conditions such as SPE cartridge, extraction solvent, extraction time, pH and elution solvent were optimized. The method was applied to determine the concentrations of these contaminants in seawater and sediments from the Yangtze River Estuary and its adjacent areas with a precision of about 10% and recoveries in the range of 67.40%-102.3% and 77.35%-101.8%, respectively. The detection limits of this method for the determination of contaminants in seawater and sediment were 0.03-0.47 ng/g and 0.01-0.58 ng/g. The method is simple to operate and has high precision, and can be applied to the detection of emerging pollutant concentrations in marine environments.
Public Preferences Regarding the Priority Setting Criteria of Health Interventions for Budget Allocation: Results of a Survey of Iranian Adults
Authors: Darvishi Ali , Daroudi Rajabali , Yaseri Mehdi , sari Ali Akbari 
Published: April 2022

Abstract
Objectives: Priority setting in health has a direct impact on the general public as payer and final consumers, so the public preferences must be considered. The present study aimed to provide public preferences about health intervention allocation criteria for the optimal allocation of public resources in the health budget in Iran.Methods: A choice-based survey method was used to assess the general public’s preferences regarding 8 important criteria with a societal aspect. 1064 adult citizens of Tehran, Iran participated in the study. Participants were asked to allocate a hypothetical budget between the two groups with differences in terms of allocation criteria. Public preferences were inferred from absolute majority responses i.e. more than 50% of participants' allocation for a criterion. To investigate the factors affecting the preferences regarding the importance of allocation criteria, the Logistic Regression Model was used. Results: Based on expressed participants’ preferences, criteria of disease severity, age, daily care needs, number of alternative interventions, individual's economic status, and diseases with absence from work were important. Thus, 77, 69, 61, 57, 54, and 51% of participants preferred to allocate the hypothetical budget to the treatment of patients with poor economic status, treatment of patients with diseases leading to absence from work, treating patients with severe diseases, treatment of diseases in need of daily care and treatment of children's diseases, respectively. Findings from the factors affecting participants' preferences regarding allocation criteria also showed that people with different characteristics had different preferences.Conclusions: Iranian general public pays special attention to the criteria of equitable allocation including patients’ economic status, criteria with societal aspects such as absenteeism from work and the need for daily care, as well as criteria with medical aspects such as disease severity and access to alternative interventions which may sometimes be less considered in decision making.
A novel model possible cardiotoxicity associated with administration of Boldenone and Tramadol, alone or in combination in Wistar rats
Authors: El-Shamarka Marwa E. A. , Asaad Gihan F. , Mowaad Noha A. , Kozman Magy R. 
Published: April 2022

Abstract
A risk of cardiotoxicity has been associated with the use of anabolic-androgenic steroids (AAS) and analgesics, several deaths have been attributed to such medications. This study investigates the effects on the heart of AAS; namely, boldenone (BOLD) and opioid analgesics; namely, tramadol (TRAM) given alone or in combination, for the first time. Forty adult male rats were randomly divided into four groups; (n = 10). Normal control group, BOLD (5 mg/kg, i.m.) per week, tramadol Hcl (TRAM) (20 mg/kg, i.p.) daily, and a combination of BOLD (5 mg/kg) and TRAM (20 mg/kg), respectively for two months. Those that received BOLD and TRAM alone and in combination showed deteriorated cardiac functions, elevated serum biochemical parameters (AST, CK) and deviations in lipid profiles, elevation in oxidative and inflammatory parameters (MDA, TNF-α & IL-1β) and decrease in GSH, up-regulated cardiac troponin I as well as distorted cardiac histopathological pictures. The current study elucidated the risk of administration of these drugs for sustained periods as well as the marked detrimental effects of using these drugs in combination.
Compartment-dependent influence of sugarcane and soil on niche differentiation in metabolites, while silicon fertilizer mediates edaphic factors and sugarcane agronomic traits
Authors: Fallah Nyumah , Pang Ziqin , Dong Fei , Zhou Yongmei , Lin Wenxiong , Fabrice Kabore Manegdebwaoga Arthur , Hu Chaohua , Yuan Zhaonian 
Published: April 2022

Abstract
As one of the vital crops globally, sugarcane (Saccharum officinarum L.) has been one of model crops for conducting metabolome research. Although many studies have focused on understanding bioactive components in specific sugarcane tissues, crucial questions have been left unanswered about the response of niche differentiation of metabolites in different compartments of sugarcane (leaf, stem and root), and soil (rhizosphere and bulk) under silicon (Si) amended soils. In this study, nontargeted metabolite profiling method was leveraged to assess the similarities and differences in the abundance and community composition of metabolites in the different sugarcane and soil compartments. Identify the compartment-specific expression patterns of metabolites, and their association with cane agronomic traits and edaphic factors. We also investigated the response of sugarcane agronomic traits and edaphic factors to Si amended soil. We found that Si fertilizer exhibited the advantages of overwhelmingly promoting the height and theoretical production of cane, and profoundly increased soil Si content by 24.8% and 27.0%, while soil available potassium (AK) was enhanced by 3.07 and 2.67 folds in the bulk and rhizosphere soils, respectively. It was also noticed that available prosperous (AP) in the rhizosphere soil tremendously increased by 105.5%. We detected 339 metabolites in 30 samples using LC-MS/MS analyses, 161 of which were classified and annotated, including organooxygen compounds (19.9%), carboxylic acids and derivatives (15.5%), fatty acyls (15.5%), flavonoids (4.4%), phenols (4.4%), and benzene and substituted derivatives (3.7%). Multivariate ANOVA analysis revealed that the variations in metabolites abundance and community were compartment-dependent. We also observed that L-fucose and naringin and raffinose enrichment in the leaf and stem were unique to the Si treatment, respectively. Taken together, the results suggested that Si utilization can have a positive impact on edaphic factors and cane agronomic traits, and variations in metabolites community are tissue-dependent.
The antagonistic effect of Rhizospheric bacteria against white rot (Sclerotium cepivorum) of Garlic (Allium sativum L.) under in vitro and in vivo conditions
Authors: Mohammed Mussa Adal , Demeke Asmare Dejen 
Published: April 2022

Abstract
Purpose: Garlic (Allium sativum L.) is the second most widely used Allium, and it is used for food, medicine, condiments, and as a commercial crop. White rot (Sclerotium cepivorum) reduces its yield and productivity. Potential antagonists and the phytopathogen, white rot were isolated and characterized from the rhizosphere and infected garlic plant.Methods: Biocontrol properties including dual culture inhibition test, hydrolytic enzyme production and production of bioactive compounds such as ammonia and cyanide were determined. Moreover, the in vivo inhibition potential of selected antagonists was evaluated under greenhouse conditions.Results: Among these isolates, 47.8% prevented white rot radial growth, with 4 (36.4%) and 2 (18.2%) showing disease incidences of 1- 4 % and 33.3 %, respectively. Among the isolates, 6(54. 6%), 10(90.9%) and 5 (45.5 %) were positive for Chitinase, cellulase and protease production. Furthermore, all and 5 (45.5 %) of the isolates were positive for ammonia and hydrogen cyanide production, respectively.Garlic plants inoculated with isolates WUGR-14 and WUGRB- 92 grew and resisted disease better. WUGRB-14, WUGRB-92, and WUGRB-8 treated garlic plants grew to a height of 142.2 %, 141.8 %, and 135.0 %, respectively, higher than the control. Plants inoculated with these isolates also acquired the largest shoot dry weights, which were 370.8 %, 333.3 %, and 291.7 % higher than the control, respectively. WUGRB- 38 exhibited 99 % sequence identity to Pantoa species, Pantoa agglomerans, and Enterobacter species based on 16S rRNA gene sequencing, whereas WUGRB- 53, 91, and 92 showed the most homology to Enterococcus species, E. casseliflavus, and E. gallinarum. Conclusion: Under appropriate circumstances, the isolates WUGRB-8, WUGRB-14, and WUGRB-92 can be recommended as candidate microbial inoculant for applying under field conditions.