bluuebunny/crossref_metadata_2025_split huggingface dataset:
A change of plan: Collaborative ambitions meet institutional realities for the Waikato River
Authors: Paterson‐Shallard Heather , Blue Brendon , Fisher Karen 
Published: April 2022

AbstractAotearoa New Zealand has shifted towards more collaborative decision‐making for freshwater in recent years, as national and local authorities seek new ways of working with communities. While the potential benefits of collaboration are well established, the messiness of collaborative processes can challenge institutional imperatives to develop formally justified, implementable plans. This paper explores a collaboration‐first attempt, ‘Healthy Rivers/Wai Ora: Proposed Waikato Regional Plan Change 1’, demonstrating that while more inclusive forms of plan‐making may better reflect diverse values, interests and knowledges, relinquishing control over planning processes can present significant challenges in the face of existing institutional structures and legislative requirements.
Quantitative proteomics in medication‐related osteonecrosis of the jaw: A proof‐of‐concept study
Authors: Lorenzo‐Pouso Alejandro I. , Bravo Susana B. , Carballo Javier , Chantada‐Vázquez María del Pilar , Bagán José , Bagán Leticia , Chamorro‐Petronacci Cintia M. , Conde‐Amboage Mercedes , López‐López Rafael , García‐García Abel , Pérez‐Sayáns Mario 
Published: April 2022

AbstractObjectiveMedication‐related osteonecrosis of the jaw (MRONJ) is a paradoxical effect associated with bone‐modifying agents (BMAs) and other drugs. Currently, no valuable diagnostic or prognosis biomarkers exist. The goal of this research was to study MRONJ‐related salivary proteome.Materials and MethodsThis case–control aimed to study salivary proteome in MRONJ versus control groups (i) formed from BMAs consumers and (ii) healthy individuals to unravel biomarkers. Thirty‐eight samples of unstimulated whole saliva (18 MRONJ patients, 10 BMA consumers, and 10 healthy controls) were collected. Proteomic analysis by SWATH‐MS coupled with bioinformatics analysis was executed.ResultsA total of 586 proteins were identified, 175 proteins showed significant differences among MRONJ versus controls. SWATH‐MS revealed differentially expressed proteins among three groups, which have never been isolated. These proteins had distinct roles including cell envelope organization, positive regulation of vesicle fusion, positive regulation of receptor binding, or regulation of low‐density lipoprotein particle clearance. Integrative analysis prioritized 3 proteins (MMP9, AACT, and HBD). Under receiver‐operating characteristic analysis, this panel discriminated MRONJ with a sensitivity of 90% and a specificity of 78.9%.ConclusionThese findings may inform a novel biomarker panel for MRONJ prediction or diagnosis. Nonetheless, further research is needed to validate this panel.
Reconstruction of Paprosky Type III Acetabular Defects by Three‐Dimensional Printed Porous Augment: Techniques and Clinical Outcomes of 18 Consecutive Cases
Authors: Fu Jun , Ni Ming , Zhu Fangzheng , Li Xiang , Chai Wei , Hao Libo , Zhou Yonggang , Zhang Guoqiang , Chen Jiying 
Published: April 2022

ObjectiveTo introduce the surgical technique of reconstruction of Paprosky type III acetabular defects by 3D printed porous augments.MethodsFirst, CT scans of pelvis were obtained to establish the 3D reconstruction model of 3D printed porous augment. Then, a nylon pelvis model was printed to simulate operation with the surgeons. At this time, the augment was designed and modified according to the surgeon's suggestions and the 3D printing principles. Eighteen patients with Paprosky type III acetabular defects receiving reconstructive surgery by 3D printed porous augments were included in current study. Their data, including general information, intra‐operative findings, imaging results, functional scores, and complications were retrospectively analyzed.ResultsThe mean follow‐up time lasted 33.3 ± 2.0 (24–56) months. The average limb‐length discrepancy (LLD) was 31.7 ± 4.2 (3–59) mm preoperatively, 7.7 ± 1.4 (1–21) mm postoperatively (P < 0.0001), and 7.5 ± 1.2 (0–18) mm at the latest follow‐up. The mean vertical position of hip center of rotation (HCOR) from the interteardrop line changed from preoperative 50.7 ± 3.9 (23.3–75.3) mm to postoperative 22.9 ± 1.9 (10.1–40.3) mm (P < 0.0001), with the latest follow‐up revealing an HCOR of 22.3 ± 1.7 (11.0–40.5) mm. Follow‐up study showed that no hip had radiolucencies and radiological loosening of the acetabular components and augment. The average Harris hip score (HHS) improved from 40.3 ± 4.5 (10.5–71) before operation to 88.4 ± 1.9 (75–97) at the last follow‐up (P < 0.0001). Moreover, follow‐up exhibited that no periprosthetic joint infection, hip dislocation, fracture, and re‐revision occurred.ConclusionSurgical treatment of Paprosky type III acetabular defect with 3D printed porous augment was simple, achieved good match between porous augment and the defect bone surface and the acetabular component, ideally restored LLD and HCOR after operation, significantly improved HHS and attained good early clinical outcomes. It is a promising personalized solution for patients with severe acetabular bone defect.
Application of multi‐locus GWAS for the detection of bruchid resistance loci in cowpea (Vigna unguiculata)
Authors: Kpoviessi Akovognon Dieudonné , Agbahoungba Symphorien , Agoyi Eric E. , Badji Arfang , Assogbadjo Achille E. , Chougourou Daniel C. , Adoukonou‐Sagbadja Hubert 
Published: April 2022

AbstractIdentification of genes associated with bruchid resistance variations in cowpea accessions would help breeders to generate new cowpea cultivars with improved resistance and quality. In this work, 107 cowpea collections from various areas in six countries were phenotyped for their responses to Callosobruchus maculatus and genotyped with Single Nucleotide Polymorphism (SNP) markers. Six multi‐locus models Genome Wide Association Study (mrMLM, FASTmrMLM, pKWmEB, pLARmEB, FASTmrEMMA and ISISEM‐BLASSO) were used to associate the genotype data to phenotypic cowpea resistance traits: Percentage of Bruchid Emergence (PBE); Percentage of Weight Loss (PWL); Median Development Period (MDP); Dobie Susceptibility Index (DSI); Number of Egg Laid (NEL) and Mean Number of Hole (MNH). Out of 14 QTNs, three were associated with more than one trait and were associated with 11 candidate genes located within 10–30 kb of the QTNs. These candidate genes exhibit functionalities associated with cowpea resistance mechanisms. All these results could contribute to the gene networks in resistant cowpea varieties. The result of this study could also increase our knowledge of genetic resistance of cowpea to bruchids and could be useful for molecular breeding.
Reckoning With Race and Gender in Public Administration and Public Policy: A Substantive Social Equity Turn
Authors: Pandey Sanjay K. , Newcomer Kathryn , DeHart‐Davis Leisha , McGinnis Johnson Jasmine , Riccucci Norma M. 
Published: April 2022

AbstractPromoting race‐aware and gender‐aware scholarship is essential for giving substance to social equity research. This review and introduction provides an account of one such initiative to promote race and gender scholarship through collaboration between Public Administration Review (PAR), and the Consortium of Race and Gender Scholars (CORGES), and introduces the PAR Race and Gender Symposium. CORGES is an informal group of scholars motivated by the pressing need to address issues of racial justice and gender justice in public administration and public policy scholarship. This PAR symposium is based on the CORGES inaugural conference, held virtually in September 2020. Conference organizers, with the help of Editor‐in‐Chief Jeremy Hall, devised and oversaw a thoughtful and detailed plan to provide developmental feedback before papers were submitted to PAR's standard peer review process. The symposium is comprised of 14 research articles and 2 viewpoint contributions. In addition to describing symposium contributions, this review provides an account of CORGES origins and its ongoing intellectual and normative commitments on furthering inquiry on racializing and gendering, while also elaborating on the idea of everydayness of scholarly activism. CORGES, with a recently expanded board of advisors committed to centering public administration scholarship on race and gender, as well its intersection with other markers of oppression, continues to support academic research and public outreach on race and gender scholarship.
Global proteomic analysis of preimplantational ovine embryos produced in vitro
Authors: S. Passos José Renato , D. Guerreiro Denise , S. Otávio Kamila , C. dos Santos‐Neto Pedro , Souza‐Neves Marcela , Cuadro Federico , Nuñez‐Olivera Richard , Crispo Martina , B. Bezerra Maria Júlia , F. Silva Renato , F. Lima Laritza , Figueiredo José Ricardo , C. Bustamante‐Filho Ivan , Menchaca Alejo , A. Moura Arlindo 
Published: April 2022

AbstractThe present study was conducted to characterize the major proteome of preimplantation (D6) ovine embryos produced in vitro. COCs were aspirated from antral follicles (2–6 mm), matured and fertilized in vitro and cultured until day six. Proteins were extracted separately from three pools of 45 embryos and separately run in SDS‐PAGE. Proteins from each pool were individually subjected to in‐gel digestion followed by LC‐MS/MS. Three ‘raw files’ and protein lists were produced by Pattern Lab software, but only proteins present in all three lists were used for the bioinformatics analyses. There were 2,262 proteins identified in the 6‐day‐old ovine embryos, including albumin, zona pellucida glycoprotein 2, 3 and 4, peptidyl arginine deiminase 6, actin cytoplasmic 1, gamma‐actin 1, pyruvate kinase, heat shock protein 90 and protein disulfide isomerase, among others. Major biological processes linked to the sheep embryo proteome were translation, protein transport and protein stabilization, and molecular functions, defined as ATP binding, oxygen carrier activity and oxygen binding. There were 42 enriched functional clusters according to the 2,147 genes (UniProt database). Ten selected clusters with potential association with embryo development included translation, structural constituent of ribosomes, ribosomes, nucleosomes, structural constituent of the cytoskeleton, microtubule‐based process, translation initiation factor activity, regulation of translational initiation, cell body and nucleotide biosynthetic process. The most representative KEEG pathways were ribosome, oxidative phosphorylation, glutathione metabolism, gap junction, mineral absorption, DNA replication and cGMP‐PKG signalling pathway. Analyses of functional clusters clearly showed differences associated with the proteome of preimplantation (D6) sheep embryos generated after in vitro fertilization in comparison with in vivo counterparts (Sanchez et al., 2021; https://doi.org/10.1111/rda.13897), confirming that the quality of in vitro derived blastocysts are unlike those produced in vivo. The present study portrays the first comprehensive overview of the proteome of preimplantational ovine embryos grown in vitro.
Social movement organizing and the politics of emotion from HIV to Covid‐19
Authors: Mackenzie Sonja 
Published: April 2022

AbstractThe Covid‐19 pandemic has seen the rapid growth of collective organizing on the part of patient groups to address scientific and health inequities. This paper considers the emergence of Covid‐19 activism as an embodied health movement that draws on and contributes to broader movements for racial, economic and gender justice. Recognizing the central role of emotion in social movements and in the bio‐politics of Covid‐19, I examine the key presence of the affective domain in social change through three Covid‐19 social movement groups. These organizations draw upon anti‐racist, feminist, and queer and HIV social movement organizing that position Covid movement building in intersectional histories and futures. I argue that Covid movement activists have built “archives of feeling”—or public cultures of trauma—of commemoration, Covid survivor narratives, and direct action that center affective feelings around grief, representation, and anger, respectively. I suggest that Covid‐19 will become a key lens for articulating structural and social inequalities through which broader social movements will leverage their claims for justice—moving towards an integrated social movement. Social movement mobilizing will continue to play a critical role to ensure that the focus in the Covid‐19 pandemic shifts from pathogen to society.
Na+ is shifted from the extracellular to the intracellular compartment and is not inactivated by glycosaminoglycans during high salt conditions in rats
Authors: Thowsen Irene Matre , Karlsen Tine V. , Nikpey Elham , Haslene‐Hox Hanne , Skogstrand Trude , Randolph Gwendalyn J. , Zinselmeyer Bernd H. , Tenstad Olav , Wiig Helge 
Published: April 2022

AbstractRecently, studies have emerged suggesting that the skin plays a role as major Na+ reservoir via regulation of the content of glycosaminoglycans and osmotic gradients. We investigated whether there were electrolyte gradients in skin and where Na+ could be stored to be inactivated from a fluid balance viewpoint. Na+ accumulation was induced in rats by a high salt diet (HSD) (8% NaCl and 1% saline to drink) or by implantation of a deoxycorticosterone acetate (DOCA) tablet (1% saline to drink) using rats on a low salt diet (LSD) (0.1% NaCl) on tap water as control. Na+ and K+ were assessed by ion chromatography in tissue eluates, and the extracellular volume by equilibration of 51Cr‐EDTA. By tangential sectioning of the skin, we found a low Na+ content and extracellular volume in epidermis, both parameters rising by ∼30% and 100%, respectively, in LSD and even more in HSD and DOCA when entering dermis. We found evidence for an extracellular Na+ gradient from epidermis to dermis shown by an estimated concentration in epidermis ∼2 and 4–5 times that of dermis in HSD and DOCA‐salt. There was intracellular storage of Na+ in skin, muscle, and myocardium without a concomitant increase in hydration. Our data suggest that there is a hydration‐dependent high interstitial fluid Na+ concentration that will contribute to the skin barrier and thus be a mechanism for limiting water loss. Salt stress results in intracellular storage of Na+ in exchange with K+ in skeletal muscle and myocardium that may have electromechanical consequences.Key points
Studies have suggested that Na+ can be retained or removed without commensurate water retention or loss, and that the skin plays a role as major Na+ reservoir via regulation of the content of glycosaminoglycans and osmotic gradients.
In the present study, we investigated whether there were electrolyte gradients in skin and where Na+ could be stored to be inactivated from a fluid balance viewpoint.
We used two common models for salt‐sensitive hypertension: high salt and a deoxycorticosterone salt diet.
We found a hydration‐dependent high interstitial fluid Na+ concentration that will contribute to the skin barrier and thus be a mechanism for limiting water loss.
There was intracellular Na+ storage in muscle and myocardium without a concomitant increase in hydration, comprising storage that may have electromechanical consequences in salt stress.
Why don’t children and young people engage with diabetes services?
Authors: Saul Helen , Gursul Deniz , Cassidy Samantha , Sharpe Darren 
Published: April 2022

The studySharpe D, Rajabi M, Harden A, et al. Supporting disengaged children and young people living with diabetes to self-care: a qualitative study in a socially disadvantaged and ethnically diverse urban area. BMJ Open 2021;11:e046989.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/why-dont-young-people-engage-with-diabetes-services/
For a structured response to the psychosocial consequences of the restrictive measures imposed by the global COVID-19 health pandemic: the MAVIPAN longitudinal prospective cohort study protocol
Authors: LeBlanc Annie , Baron Marie , Blouin Patrick , Tarabulsy George , Routhier Francois , Mercier Catherine , Despres Jean-Pierre , Hébert Marc , De Koninck Yves , Cellard Caroline , Collin-Vézina Delphine , Côté Nancy , Dionne Émilie , Fleet Richard , Gagné Marie-Hélène , Isabelle Maripier , Lessard Lily , Menear Matthew , Merette Chantal , Ouellet Marie-Christine , Roy Marc-André , Saint-Jacques Marie-Christine , Savard Claudia 
Published: April 2022

IntroductionThe COVID-19 pandemic and associated restrictive measures have caused important disruptions in economies and labour markets, changed the way we work and socialise, forced schools to close and healthcare and social services to reorganise. This unprecedented crisis forces individuals to make considerable efforts to adapt and will have psychological and social consequences, mainly on vulnerable individuals, that will remain once the pandemic is contained and will most likely exacerbate existing social and gender health inequalities. This crisis also puts a toll on the capacity of our healthcare and social services structures to provide timely and adequate care. The MAVIPAN (Ma vie et la pandémie/ My Life and the Pandemic) study aims to document how individuals, families, healthcare workers and health organisations are affected by the pandemic and how they adapt.Methods and analysisMAVIPAN is a 5-year longitudinal prospective cohort study launched in April 2020 across the province of Quebec (Canada). Quantitative data will be collected through online questionnaires (4–6 times/year) according to the evolution of the pandemic. Qualitative data will be collected with individual and group interviews and will seek to deepen our understanding of coping strategies. Analysis will be conducted under a mixed-method umbrella, with both sequential and simultaneous analyses of quantitative and qualitative data.Ethics and disseminationMAVIPAN aims to support the healthcare and social services system response by providing high-quality, real-time information needed to identify those who are most affected by the pandemic and by guiding public health authorities’ decision making regarding intervention and resource allocation to mitigate these impacts. MAVIPAN was approved by the Ethics Committees of the Primary Care and Population Health Research Sector of CIUSSS de la Capitale-Nationale (Committee of record) and of the additional participating institutions.Trial registration numberNCT04575571.
Multivariate decomposition of trends, inequalities and predictors of skilled birth attendants utilisation in Nigeria (1990–2018): a cross-sectional analysis of change drivers
Authors: Fagbamigbe Adeniyi Francis , Oyedele Oyewole Kazeem 
Published: April 2022

ObjectivesLiterature has assessed skilled birth attendants (SBAs) utilisation, but little is known about what contributes to the changes in SBA use. Multivariate decomposition analysis was thus applied in this study to examine; levels, trends, inequalities and drivers of changes in SBA utilisation.Design and settingA cross-sectional analysis of five-waves of NDHS-data (1990, 2003, 2008, 2013, and 2018), collected through similar multistage sampling across the 36 states and the federal-capital-territory of Nigeria.ParticipantsWomen of reproductive age (15–49 years), and with at least one birth in the last 5 years preceding each of the surveys.Main outcome measureSBA use is the response variable while explanatory variables were classified into; Demographics, Health, Economic and Corporal factors.MethodsChi-square test for trends of proportions across the ordered survey years assessed trends in SBA use. MDA that quantifies and partition predictors effect into endowment and coefficient components evaluated contributors to changes in SBA use. Statistical analysis was carried out at a 95% confidence interval in Stata 16.ResultsSBA use increased with significant (p<0.05) linear trends by 12% between 2003 and 2018. The decomposition analysis showed that differences in characteristics (endowment) accounted for 11.5% of the changes while the remaining 88.5% were due to differences in effects (coefficient). SBA utilisation rises by 61% when respondents decided on her health compared to when such decisions were made by the spouse. Utilisation of SBA, however, fell by 88% among women who reside in the states with high rural populations percentage.ConclusionsSBA use remained low in Nigeria, and slowly increase at the rate of <1% yearly. Women health decision-making power contributed most to positive changes. Residing in states with high rural populations has a negative impact on SBA use. Maternal health programmes that strengthen women’s health autonomy and capacity building in rural communities should be encouraged.
How did the adoption of wP-pentavalent affect the global paediatric vaccine coverage rate? A multicountry panel data analysis
Authors: Khan M Mahmud , Vargas-Zambrano Juan Camilo , Coudeville Laurent 
Published: April 2022

ObjectivesSeveral studies have highlighted the effects of combination vaccines on immunisation coverage at the national or subnational level. This study examined the effects globally. Worldwide introduction of whole-cell pertussis pentavalent (wP-pentavalent) allowed estimation of incremental coverage effects of combination vaccines on the third doses of diphtheria, tetanus, pertussis (DTP3); hepatitis B (HepB3) andHaemophilus influenzaetype B (Hib3).DesignMulticountry panel data analysis.Data sourcesCountry-level vaccine coverage data of WHO/UNICEF for the years 1980–2018.MethodsLinear mixed models were used to estimate the effects of wP-pentavalent introduction by incorporating proxy variables to control for time trend and other time-dependent changes in the immunisation programmes.ResultsIntroduction of combination vaccines may have improved the coverage of DTP3 by 3percentage points(95% CI 2.5% to 3.6%) globally compared with the coverage in the pre-combination vaccine era. The comparison of coverage rates of HepB3 and Hib3 in before and after wP-pentavalent periods indicates that the introduction of combination vaccines improved the coverage by 10.1 percentage points (95% CI 8.4% to 11.7%) for HepB3 and 9.9 (95% CI 7.1% to 12.7%) for Hib3 in countries that introduced those antigens prior to adoption of wP-pentavalent. Even though the incremental coverage increase of DTP3 appears quite modest, it is still a significant result, especially because DTP vaccine has been in the national immunisation programmes of all countries for about 24 years prior to the introduction of wP-pentavalent. Additionally, the introduction of pentavalent also allowed inclusion of Hib and HepB in the vaccine schedule for a large number of countries (85 and 37, respectively, of the 102 countries included in our analysis).ConclusionThe findings suggest that development of combination vaccines with additional antigens is likely to help sustain and improve coverage of existing as well as new childhood vaccines.