bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Transperitoneal and Retroperitoneal Robotic Partial Nephrectomy for Patients With Complete Upper Pole Renal Tumors
Authors: Gu Liangyou , Zhao Wenlei , Xu Junnan , Wang Baojun , Cheng Qiang , Shen Donglai , Xuan Yundong , Zhao Xupeng , Li Hongzhao , Ma Xin , Zhang Xu 
Published: January 2022

ObjectivesWe compared the outcomes of transperitoneal robotic partial nephrectomy (TRPN) and retroperitoneal robotic partial nephrectomy (RRPN) for complete upper pole renal masses (1 point for the “L” component of the RENAL scoring system).Material and MethodsWe retrospectively reviewed patients who underwent either TRPN or RRPN from 2013 to 2016. Baseline demographics and perioperative, functional, and oncological results were compared. Multivariable analysis was performed to identify factors related to pentafecta achievement (ischemia time ≤25 min, negative margin, perioperative complication free, glomerular filtration rate (eGFR) preservation &gt;90%, and no chronic kidney disease upstaging).ResultsNo significant differences between TRPN vs. RRPN were noted for operating time (110 vs. 114 min, p = 0.870), renal artery clamping time (19 vs. 18 min, p = 0.248), rate of positive margins (0.0% vs. 3.3%, p = 0.502), postoperative complication rates (25.0% vs. 13.3%, p = 0.140). TRPN was associated with a more estimated blood loss (50 vs. 40 ml, p = 0.004). There were no significant differences in pathologic variables, rate of eGFR decline for postoperative 12-month (9.0% vs. 7.1%, p = 0.449) functional follow-up. Multivariate analysis identified that only RENAL score (odd ratio: 0.641; 95% confidence interval: 0.455–0.904; p = 0.011) was independently associated with the pentafecta achievement.ConclusionsFor completely upper pole renal masses, both TRPN and RRPN have good and comparable results. Both surgical approaches remain viable options in the treatment of these cases.
Cell Origin and iNOS Function Are Critical to Macrophage Activation Following Acute Lung Injury
Authors: Golden Thea N. , Venosa Alessandro , Gow Andrew J 
Published: January 2022

In the intratracheal bleomycin (ITB) model of acute lung injury (ALI), macrophages are recruited to the lung and participate in the inflammation and resolution that follows injury. Macrophage origin is influential in determining activation; however, the specific phenotype of recruited and resident macrophages is not known. Inducible nitric oxide synthase (iNOS) has been implicated in the pathogenesis of ALI; however, the effects of its inhibition are mixed. Here we examined how macrophage origin determines the phenotypic response to ALI. Further, we hypothesize cell specific iNOS is key to determining activation and recruitment. Using a chimeric mouse approach, we have identified recruited and resident macrophage populations. We also used the chimeric mouse approach to create either pulmonary or bone marrow NOS2−/−mice and systemically inhibited iNOS via 1400 W. We evaluated macrophage populations at the peak of inflammation (8 days) and the beginning of resolution (15 days) following ITB. These studies demonstrate tissue resident macrophages adopt a M2 phenotype specifically, but monocyte originated macrophages activate along a spectrum. Additionally, we demonstrated that monocyte originating macrophage derived iNOS is responsible for recruitment to the lung during the inflammatory phase. Further, we show that macrophage activation is dependent upon cellular origin. Finally, these studies suggest pulmonary derived iNOS is detrimental to the lung following ITB. In conclusion, macrophage origin is a key determinant in response to ALI and iNOS is central to recruitment and activation.
Efficacy and Safety of DL-3-n-Butylphthalide in the Treatment of Poststroke Cognitive Impairment: A Systematic Review and Meta-Analysis
Authors: Fan Xueming , Shen Wei , Wang Liuding , Zhang Yunling 
Published: January 2022

Background: Poststroke cognitive impairment (PSCI) is a common complication observed after stroke. Current pharmacologic therapies have no definitive evidence for cognitive recovery or disease progression. Recent studies have verified the positive effect of DL-3-n-butylphthalide (NBP). However, the clinical efficacy and safety are still unclear. The aim of this study was to assess the efficacy of NBP and its harmful effect in the treatment of PSCI.Method: Eligible randomized controlled trials (RCTs) were retrieved from inception to June 2021 from seven medical databases and two clinical registries. The revised Cochrane risk of bias tool (RoB 2.0) was used for methodological quality. RevMan v5.4.1 from Cochrane Collaboration was used for statistical analysis, and Hartung-Knapp-Sidik-Jonkman (HKSJ) method was used for post hoc testing depend on the number of studies. This study has been submitted to PROSPERO with registration number is CRD42021274123.Result: We identified 26 studies with a total sample size of 2,571 patients. The results of this study showed that NBP as monotherapy or combination therapy had better performance in increasing the MoCA (monotherapy: SMDN = 1.05, 95% CI [0.69, 1.42], p &lt; 0.00001; SMDP = 1.06, 95% CI [0.59, 1.52], p &lt; 0.00001. combination: SMDO = 0.81, 95% CI [0.62, 1.01], p &lt; 0.00001; SMDN = 0.90, 95% CI [0.46, 1.33], p &lt; 0.0001; SMDD = 1.04, 95% CI [0.71, 1.38], p &lt; 0.00001), MMSE (monotherapy: MDN = 4.89, 95% CI [4.14, 5.63]), p &lt; 0.00001). combination: SMDO = 1.26, 95% CI [0.97, 1.56], p &lt; 0.00001; SMDC = 1.63, 95% CI [1.28, 1.98], p &lt; 0.00001; SMDN = 2.13, 95% CI [1.52, 2.75], p &lt; 0.00001) and BI (monotherapy: MDN = 13.53, HKSJ 95% CI [9.84, 17.22], p = 0.014. combination: SMDO = 2.24, HKSJ 95%CI [0.37, 4.11], p = 0.032; SMDC = 3.36, 95%CI [2.80, 3.93], p &lt; 0.00001; SMDD = 1.48, 95%CI [1.13, 1.83], p &lt; 0.00001); and decreasing the NIHSS (monotherapy: MDN = −3.86, 95% CI [−5.22, −2.50], p &lt; 0.00001. combination: SMDO = −1.15, 95% CI [−1.31, −0.98], p &lt; 0.00001; SMDC = −1.82, 95% CI [−2.25, −1.40], p &lt; 0.00001) and CSS (combination: MDO = −7.11, 95% CI [−8.42, −5.80], p &lt; 0.00001), with no serious adverse reactions observed. The funnel plot verified the possibility of publication bias.Conclusion: NBP maintains a stable pattern in promoting the recovery of cognitive function and abilities of daily living, as well as reducing the symptoms of neurological deficits. However, there is still a need for more high-quality RCTs to verify its efficacy and safety.
Large Time Behavior on the Linear Self-Interacting Diffusion Driven by Sub-Fractional Brownian Motion II: Self-Attracting Case
Authors: Guo Rui , Gao Han , Jin Yang , Yan Litan 
Published: January 2022

In this study, as a continuation to the studies of the self-interaction diffusion driven by subfractional Brownian motion SH, we analyze the asymptotic behavior of the linear self-attracting diffusion:dXtH=dStH−θ∫0t(XtH−XsH)dsdt+νdt,X0H=0,where θ &gt; 0 and ν∈R are two parameters. When θ &lt; 0, the solution of this equation is called self-repelling. Our main aim is to show the solution XH converges to a normal random variable X∞H with mean zero as t tends to infinity and obtain the speed at which the process XH converges to X∞H as t tends to infinity.
Effectiveness of a Transtheoretical Model-Based Intervention to Improve Blood Pressure Control of Hypertensive Patients in China: A Clustered Randomized Controlled Trial
Authors: Chen Ping , Shen Ying , He Chao , Sun Xinying 
Published: January 2022

BackgroundHypertension can result in great cardiovascular risk, while medication adherence and blood pressure control of patients were suboptimal. Therefore, we conducted a 12-month clustered randomized controlled trial to evaluate the effectiveness of transtheoretical model (TTM)-based health intervention mode on blood pressure of Chinese newly-diagnosed hypertensive patients.MethodsThis trial was conducted in six primary healthcare centers, Shunyi District, Beijing, China from September 2016 to September 2017. A total of 400 patients were included and randomized, 194 patients in the control group and 206 patients in the intervention group. Patients in the intervention group received TTM-based health intervention and those in the control group received usual care. Multilevel modeling was used to adjust for clustering effect and repeated measurements.ResultsSystolic blood pressure of patient was reduced by 4.534 mm Hg at 3-month follow-up [95% CI (−3.054, −1.403), p = 0.005], 3.982 mm Hg at 6-month follow-up [95% CI (−7.387, −0.577), p = 0.022], and 5.803 mm Hg at 12-month follow-up [95% (−9.716, −1.891), p = 0.004]. Diastolic blood pressure of patient was reduced by 3.383 mm Hg at 3-month follow-up [95% CI (−5.724, −1.042), p = 0.005], 0.330 mm Hg at 6-month follow-up [95% CI (−2.870, 2.210), p = 0.799], and 3.129 mm Hg at 12-month follow-up [95% CI (−6.048, −0.21), p = 0.036]. Medication adherence of patients was improved at all the three time points. For stages of change for taking medication, patients in the intervention group were 8.401-fold more likely to be in a higher stage at 3-month follow-up [95% CI (4.186, 16.862), p &lt; 0.001]. The odds ratio of being in a higher stage was 8.454 at 6-month follow-up [95% CI (3.943, 18.123), p &lt; 0.001] and 19.263 at 12-month follow-up [95% CI (7.979, 46.505), p &lt; 0.001].ConclusionTranstheoretical model-based health intervention might be a promising strategy to improve medication adherence of newly-diagnosed hypertensive patients in community.
Investigating the Usability, Efficacy and Accuracy of a Medication Entering Software System for a Healthcare Robot
Authors: Martini Nataly , Broadbent Elizabeth , Koo Jasmine , Lam Laurence , Verches Diane , Zeng Sophie , Montgomery-Walsh Rhea , Sutherland Craig 
Published: January 2022

Purpose: This research aimed to evaluate medication software for a healthcare robot. Study I compared two software versions (RoboGen and RoboGen2) for system usability, speed and accuracy of medication entry; Study II evaluated system usability and community pharmacists’ views of RoboGen2.Methods: Study I had a within-subjects experimental design and recruited 40 Health Sciences students to enter different, comparable sets of prescriptions into the two systems, in randomized order, within a limit of 15 min. Screen activity was recorded to observe prescription errors. Study II had a cross-sectional observational design and recruited 20 community pharmacists using convenience sampling. Pharmacists entered three prescriptions using RoboGen2. Participants in both studies completed the System Usability Scale (SUS) following each task. Study I participants completed a questionnaire on system preference, and Study II participants a semi-structured interview.Results: Study I participants preferred Robogen2 (p &lt; 0.001) due to its sleek and modern layout, good flow, ease of use, and intuitive design. SUS scores [t (40) = −3.40, p = 0.002] and speed of medication entry favored Robogen2 (t = 3.65, p &lt; 0.001). No significance was found in accuracy (t = 1.12, p = 0.27). In study 2, pharmacists rated the usability of RoboGen2 below average. Themes from interviews were navigation and streamlining the system, ease of use, and integration with pharmacy software systems.Conclusion: Adding safety features and better aesthetics can improve the usability and safety of a medication prescription system. Streamlining workflow and pre-populating data can increase speed of prescription entry without compromising patient safety. However, a better approach is integration with pre-existing pharmacy systems to reduce workload while incorporating safety features built into existing dispensing systems.
Effect of CAD/CAM Guide Plate Combined With Socket-Shield Technique in Immediate Implantation of Anterior Teeth Aesthetic Area and Its Influence on Aesthetics
Authors: Wang Zhigang , Liu Jianwei , Wang Xinquan , Wang Ning , Teng Min 
Published: January 2022

PurposeThe purpose of this study is to discuss the effect of computer-aided design or computer-aided manufacturing (CAD/CAM) guide plate combined with socket-shield technique (SST) in immediate implantation of anterior teeth aesthetic area and its influence on aesthetics.MethodsA total of 102 patients with immediate implantation in our hospital from March 2017 to March 2020 were selected. According to different repair methods, patients were divided into conventional group (n = 51) and observation group (n = 51). Traditional immediate implantation was performed in conventional group. The observation group underwent immediate implantation with CAD/CAM guides combined with SST. Immediately after operation and 12 months after operation, the success rate, implant deviation, periodontal index, absorption of labial bone plate, complications, aesthetic effects, and satisfaction of the two groups were observed.ResultsThere was no significant difference in the success rate between the two groups (p &gt; 0.05). The implant deviation values in the observation group were all lower than those in the conventional group (p &lt; 0.05). PD, PLI, and SBI in the observation group were all lower than those in the conventional group (p &lt; 0.05). The absorption value of labial bone plate in the observation group were all lower than those in the conventional group (p &lt; 0.05). The total incidence of complications in the observation group (5.88%) was lower than that in the conventional group (19.61%) (p &lt; 0.05). The PES and WES in the observation group were higher than those in the conventional group (p &lt; 0.05). The total satisfaction in the observation group (92.16%) was higher than that in the conventional group (76.47%) (p &lt; 0.05).Conclusion: The application of CAD/CAM guide plate combined with SST in immediate implantation of anterior teeth aesthetic area has a good effect, which can improve the accuracy of implantation, improve the periodontal environment, reduce bone resorption, reduce complications, improve aesthetics, and have high patient's satisfaction.
Comparison of Hydrocortisone Continuous Rate Infusion and Prednisolone or Dexamethasone Administration for Treatment of Acute Hypoadrenocortical (Addisonian) Crisis in Dogs
Authors: Mitropoulou Athanasia , Häuser Mia-Katharina , Lehmann Hendrik , Hazuchova Katarina 
Published: January 2022

ObjectivesTo determine whether administration of intravenous hydrocortisone is a safe and effective alternative treatment in comparison to the traditional treatment with prednisolone/dexamethasone in dogs presenting with Addisonian crisis; and to assess if there is any advantage of the former over the latter in normalisation of electrolyte imbalances and in hospitalisation length in these dogs.MethodsMedical records of client-owned dogs with hypoadrenocorticism were retrospectively reviewed. Time until normalisation of sodium and potassium concentration, intravenous fluid needs over the first 24 h and hospitalisation length were compared between hydrocortisone and prednisolone/dexamethasone treated dogs.ResultsTwenty-five dogs met the inclusion criteria; 13 received hydrocortisone and 12 prednisolone/dexamethasone. Intravenous hydrocortisone was well-tolerated but failed to prove superiority in terms of time to normalisation of sodium and potassium concentration. Interestingly, potassium normalised in all dogs prior to discharge, but sodium did not in 1/11 hydrocortisone and 5/9 prednisolone/dexamethasone treated dogs with initial hyponatraemia (p = 0.05). Hydrocortisone treated dogs, however, had more electrolyte re-checks [hydrocortisone treated dogs, median (range): 4 (2–16); prednisolone/dexamethasone treated dogs: 2 (0–6); p = 0.001]. There was no difference in intravenous fluid needs over the first 24 h but hydrocortisone treated dogs had longer hospitalisation [hydrocortisone: 81 (45–309) h; prednisolone/dexamethasone: 52 (22–138) h; p = 0.01].Clinical SignificanceIntravenous hydrocortisone is well-tolerated and safe, but no clear additional benefit over traditional glucocorticoid replacement could be identified. Also, it might result in longer hospitalisation time and more intensive monitoring.
Continuity of GP care for patients with dementia: impact on prescribing and the health of patients
Authors: Delgado João , Evans Philip H , Gray Denis Pereira , Sidaway-Lee Kate , Allan Louise , Clare Linda , Ballard Clive , Masoli Jane , Valderas Jose M , Melzer David 
Published: January 2022

BackgroundHigher continuity of GP care (CGPC), that is, consulting the same doctor consistently, can improve doctor–patient relationships and increase quality of care; however, its effects on patients with dementia are mostly unknown.AimTo estimate the associations between CGPC and potentially inappropriate prescribing (PIP), and with the incidence of adverse health outcomes (AHOs) in patients with dementia.Design and settingA retrospective cohort study with 1 year of follow-up anonymised medical records from 9324 patients with dementia, aged ≥65 years living in England in 2016.MethodCGPC measures include the Usual Provider of Care (UPC), Bice–Boxerman Continuity of Care (BB), and Sequential Continuity (SECON) indices. Regression models estimated associations with PIPs and survival analysis with incidence of AHOs during the follow-up adjusted for age, sex, deprivation level, 14 comorbidities, and frailty.ResultsThe highest quartile (HQ) of UPC (highest continuity) had 34.8% less risk of delirium (odds ratio [OR] 0.65, 95% confidence interval [CI] = 0.51 to 0.84), 57.9% less risk of incontinence (OR 0.42, 95% CI = 0.31 to 0.58), and 9.7% less risk of emergency admissions to hospital (OR 0.90, 95% CI = 0.82 to 0.99) compared with the lowest quartile. Polypharmacy and PIP were identified in 81.6% (n = 7612) and 75.4% (n = 7027) of patients, respectively. The HQ had fewer prescribed medications (HQ: mean 8.5, lowest quartile (LQ): mean 9.7, P<0.01) and had fewer PIPs (HQ: mean 2.1, LQ: mean 2.5, P<0.01), including fewer loop diuretics in patients with incontinence, drugs that can cause constipation, and benzodiazepines with high fall risk. The BB and SECON measures produced similar findings.ConclusionHigher CGPC for patients with dementia was associated with safer prescribing and lower rates of major adverse events. Increasing continuity of care for patients with dementia may help improve treatment and outcomes.
The Christian Experience of Life and the Task of Phenomenology
Authors: van der Heiden Gert-Jan 
Published: January 2022

It is well-known that the early Heidegger offers important reflec- tions on the Christian experience of life in his accounts of Saint Paul and Saint Augustine. Yet, what is the systematic meaning of Heidegger’s phenomenology of religion? This essay aims to discuss this question by connecting themes from Die Phänomenologie des religiösen Lebens to Heidegger’s attempt to provide his own version of phenomenology in Einführung in die phänomenologische Forschung. Heidegger’s position with respect to Husserl’s phenomenology becomes clearer, I argue, when his problematization of the onto-theological structures he discerns at the heart of the philosophers he discusses, such as Descartes and Augustine, is taken into account and when it is shown how the phenomenology of religion exceeds the boundaries of a phenomenology that studies consciousness alone. In fact, the explication of the (purified) Christian experience of life and the concep- tion of God at stake in this experience allows Heidegger to articulate a form of phenomenology purified from onto-theological tendencies.
Hubungan Aktivitas Fisik dengan Kejadian Obesitas pada Remaja di SMA Swasta Cerdas Bangsa, Kecamatan Deli Tua, Kabupaten Deli Serdang, Medan
Authors: Sembiring Bela Aprilia , Rosdewi Naomi Nisari , Yuningrum Hesti 
Published: January 2022

Salah satu PTM yang menjadi masalah kesehatan di berbagai negara yaitu obesitas yang merupakan suatu kelainan ataupun penyakit yang ditandai dengan penumpukan jaringan lemak yang berlebihan di dalam badan. Obesitas salah satu permasalahan yang sangat dikhawatirkan oleh remaja. Salah satu aspek yang bisa mempengaruhi terjadinya obesitas adalah aktifitas fisik karena saat ini telah terjadi perubahan gaya hidup dari yang aktif bergerak menjadi gaya hidup yang kurang bergerak. Dahulu permainan yang biasanya dimainkan merupakan permainan fisik yang mewajibkan berlari, melompat, ataupun melakukan gerakan yang lain tetapi saat ini sudah diganti dengan permainan yang kurang aktifitas fisik seperti permainan komputer atau elektronik, bermain internet ataupun menonton televisi tanpa harus bergerak. Tujuan penelitian untuk mengetahui hubungan aktivitas fisik dengan obesitas pada remaja di SMA Swasta Cerdas Bangsa Kecamatan Deli Tua Kabupaten Deli Serdang Medan. Jenis penelitian yaitu cross sectional dengan teknik stratified random sampling. Jumlah sampel 115 orang, terdiri dari kelas, 10, 11 & 12. Instrumen penelitian untuk mengukur aktivitas fisik menggunakan Global Physical Activity Questionnaire (GPAQ) dan untuk mengetahui obesitas menggunakan Indeks Masa Tubuh (IMT). Analisis data yaitu univariat dan bivariat mengunakan uji fisher exact. Hasil univariat menunjukkan aktivitas fisik rendah sebanyak 47 orang (40,9%) dan obesitas 31 orang (27,0%). Hasil bivariat menunjukkan bahwa hubungan aktivitas fisik dengan obesitas pada remaja diperoleh nilai p-value 0,021. Kesimpulannya ada hubungan aktivitas fisik dengan obesitas pada remaja di SMA Swasta Cerdas Bangsa Kecamatan Deli Tua Kabupaten Deli Serdang Medan.
Analisis Penerapan Stop Buang Air Besar Sembarangan Pada Masyarakat Di Pasayangan Martapura Kabupaten Banjar
Authors: Irianty Hilda , Hayati Ridha , Mahmudah Mahmudah 
Published: January 2022

Permasalahan yang muncul pada kebiasaan masyarakat Pasayangan yang memilki kebiasan Permasalahan yang muncul pada kebiasaan masyarakat Pasayangan yang memilki kebiasan MCK di aliran sungai. Sehingga pemerintah kab. Banjar mencanangkan untuk program pembangunan jamban keluarga di setiap rumah pemduduk dan penghapusan jamban apung disungai. Penghapusan jamban apung tersebut bagian dari upaya Pemerintah Kabupaten Banjar meningkatkan sanitasi dan mendorong masyarakat hidup lebih sehat, terutama yang bermukim di bantaran sungai. Pasalnya, berdasar penelitian, air di Sungai Martapura mengandung bakteri e-coli mencapai 9.000 hingga 10.000 ppm (part per milion). Tujuan penelitian ini adalah untuk mengetahui dan menganalisis hubungan pengetahuan dan persepsi dengan pemanfaatan jamban keluarga. Metode penelitian ini adalah bersifat deskriptif analitik dengan pendekatan crossectional study. Dengan populasi sebanyak 60 responden dan sampel sampel diambil secara Total Population dengan menggunakan teknik accidental sampling namun pada pelaksanaan hanya mendapatkan 57 responden karena 2 orang responden menolak dengan alasan sakit dan 1 orang sudah pindah ke tempat lain (rumah kosong). Instrumen yang digunakan adalah kuesioner dengan metode wawancara, Teknik pengumpulan data ada 2 yaitu data primer dan data sekunder yang mana pengumpulan data dilakukan selama 2 minggu. Pengolahan dan analisa data menggunakan uji-chi square dengan tingkat kepercayaan 95%. Hasil penelitian yang didapat dari 57 responden terdapat 30 responden (52,6%) yang kadang-kadang memanfaatkan jamban keluarga di Kelurahan Pasayangan. Dari hasil analisis bivariat ada hubungan antara variabel pengetahuan (p-Value=0,008) dan persepsi (p-Value=0,046) dengan pemanfaatan jamban keluarga pada masyarakat di Kelurahan Pasayangan. Kesimpulan dari penelitian ini adalah perilaku keluarga dipicu oleh kurangnya pengetahuan tentang bahaya pembuangan feses yang sembarangan, disamping persepsi bahwa lumrah feses di buang di tanah atau sungai juga membuat masyarakat di Kelurahan Pesayangan kadang tidak menggunakan jamban keluarga.