bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medicinal Plant Extracts and Natural Compounds for the Treatment of Cutaneous Lupus Erythematosus: A Systematic Review
Authors: Lubov Janet E. , Jamison Aisha S. , Baltich Nelson Becky , Amudzi Alice A. , Haas Kelly N. , Richmond Jillian M. 
Published: March 2022

Cutaneous lupus erythematosus (CLE) is a group of autoimmune connective tissue disorders that significantly impact quality of life. Current treatment approaches typically use antimalarial medications, though patients may become recalcitrant. Other treatment options include general immunosuppressants, highlighting the need for more and more targeted treatment options. The purpose of this systematic review was to identify potential compounds that could be repurposed for CLE from natural products since many rheumatologic drugs are derived from natural products, including antimalarials. This study was registered with PROSPERO, the international prospective register of systematic reviews (registration number CRD42021251048). We comprehensively searched Ovid Medline, Cochrane Library, and Scopus databases from inception to April 27th, 2021. These terms included cutaneous lupus erythematosus; general plant, fungus, bacteria terminology; selected plants and plant-derived products; selected antimalarials; and JAK inhibitors. Our search yielded 13,970 studies, of which 1,362 were duplicates. We screened 12,608 abstracts, found 12,043 to be irrelevant, and assessed 565 full-text studies for eligibility. Of these, 506 were excluded, and 59 studies were included in the data extraction. The ROBINS-I risk of bias assessment tool was used to assess studies that met our inclusion criteria. According to our findings, several natural compounds do reduce inflammation in lupus and other autoimmune skin diseases in studies using in vitro methods, mouse models, and clinical observational studies, along with a few randomized clinical trials. Our study has cataloged evidence in support of potential natural compounds and plant extracts that could serve as novel sources of active ingredients for the treatment of CLE. It is imperative that further studies in mice and humans are conducted to validate these findings.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=251048.
A 4 bp InDel in the Promoter of Wheat Gene TaAFP-B Affecting Seed Dormancy Confirmed in Transgenic Rice
Authors: Feng Yumei , Han Yang , Han Bing , Zhao Yongying , Yang Yan , Xing Yanping 
Published: March 2022

BackgroundWheat (Triticum aestivum L.) ABA insensitive five (ABI5) binding protein gene (TaAFP) is a homologue of the ABI5 binding protein (AFP) gene in Arabidopsis thaliana. It is well documented that AtAFP is a negative regulator of ABA signaling that regulates embryo germination and seed dormancy. TaABI5 was earlier shown to be expressed specifically in seed and its transcript accumulated during wheat grain maturation and acquisition of dormancy. It plays an important role in seed dormancy. In a previous study, we identified two allelic variants TaAFP-B1a and TaAFP-B1b of TaAFP on chromosome arm 2BS in common wheat, designated as, respectively. Sequence analysis revealed a 4 bp insertion in the promoter of TaAFP-B1a compared with TaAFP-B1b that affected mRNA transcription level, mRNA stability, GUS and tdTomatoER translation level, and GUS activity determining seed dormancy.ResultsThe transcription and translation levels of TaAFP-B were significantly reduced in TaAFP-Ba and TaAFP-Ba-GFP transgenic plants compared with TaAFP-Bb and TaAFP-Bb-GFP. The average GI (germination index) values of TaAFP-Ba and TaAFP-Ba-GFP were significantly lower than those of TaAFP-Bb and TaAFP-Bb-GFP in T1 and T2 transgenic rice seeds, whereas mature TaAFP-Ba and TaAFP-Ba-GFP transgenic seeds exhibited increased ABA sensitivity and content of endogenous ABA compared with TaAFP-Bb and TaAFP-Bb-GFP.ConclusionThe 4 bp insertion in the promoter of TaAFP-Ba decreased transcript abundance and translation level in transgenic rice. This insertion increased sensitivity to ABA and content of endogenous ABA in mature seeds, leading to a higher seed dormancy and pre-harvest sprouting tolerance in transgenic rice.
Prediction Models for Radiation-Induced Neurocognitive Decline in Adult Patients With Primary or Secondary Brain Tumors: A Systematic Review
Authors: Tohidinezhad Fariba , Di Perri Dario , Zegers Catharina M. L. , Dijkstra Jeanette , Anten Monique , Dekker Andre , Van Elmpt Wouter , Eekers Daniëlle B. P. , Traverso Alberto 
Published: March 2022

PurposeAlthough an increasing body of literature suggests a relationship between brain irradiation and deterioration of neurocognitive function, it remains as the standard therapeutic and prophylactic modality in patients with brain tumors. This review was aimed to abstract and evaluate the prediction models for radiation-induced neurocognitive decline in patients with primary or secondary brain tumors.MethodsMEDLINE was searched on October 31, 2021 for publications containing relevant truncation and MeSH terms related to “radiotherapy,” “brain,” “prediction model,” and “neurocognitive impairments.” Risk of bias was assessed using the Prediction model Risk Of Bias ASsessment Tool.ResultsOf 3,580 studies reviewed, 23 prediction models were identified. Age, tumor location, education level, baseline neurocognitive score, and radiation dose to the hippocampus were the most common predictors in the models. The Hopkins verbal learning (n = 7) and the trail making tests (n = 4) were the most frequent outcome assessment tools. All studies used regression (n = 14 linear, n = 8 logistic, and n = 4 Cox) as machine learning method. All models were judged to have a high risk of bias mainly due to issues in the analysis.ConclusionExisting models have limited quality and are at high risk of bias. Following recommendations are outlined in this review to improve future models: developing cognitive assessment instruments taking into account the peculiar traits of the different brain tumors and radiation modalities; adherence to model development and validation guidelines; careful choice of candidate predictors according to the literature and domain expert consensus; and considering radiation dose to brain substructures as they can provide important information on specific neurocognitive impairments.
Association Between Sulfur Dioxide and Daily Inpatient Visits With Respiratory Diseases in Ganzhou, China: A Time Series Study Based on Hospital Data
Authors: Zhou Xingye , Gao Yanfang , Wang Dongming , Chen Weihong , Zhang Xiaokang 
Published: March 2022

BackgroundSulfur dioxide (SO2) has been reported to be related to the mortality of respiratory diseases, but the relationship between SO2 and hospital inpatient visits with respiratory diseases and the potential impact of different seasons on this relationship is still unclear.MethodsThe daily average concentrations of air pollutants, including SO2 and meteorological data in Ganzhou, China, from 2017 to 2019 were collected. The data on daily hospitalization for respiratory diseases from the biggest hospital in the city were extracted. The generalized additive models (GAM) and the distributed lag non-linear model (DLNM) were employed to evaluate the association between ambient SO2 and daily inpatient visits for respiratory diseases. Stratified analyses by gender, age, and season were performed to find their potential effects on this association.ResultsThere is a positive exposure-response relationship between SO2 concentration and relative risk of respiratory inpatient visits. Every 10 μg/m3 increase in SO2 was related to a 3.2% (95% CI: 0.6–6.7%) exaltation in daily respiratory inpatient visits at lag3. In addition, SO2 had a stronger association with respiratory inpatient visits in women, older adults (≥65 years), and warmer season (May-Oct) subgroups. The relationship between SO2 and inpatient visits for respiratory diseases was robust after adjusting for other air pollutants, including PM10, NO2, O3, and CO.ConclusionThis time-series study showed that there is a positive association between short-term SO2 exposure and daily respiratory inpatient visits. These results are important for local administrators to formulate environmental public health policies.
Associations of Humidity and Temperature With Cataracts Among Older Adults in China
Authors: Lv Xiaoyang , Gao Xiangyang , Hu Kejia , Yao Yao , Zeng Yi , Chen Huashuai 
Published: March 2022

BackgroundThe burden of cataracts was substantial in the current aging world. However, few epidemiological studies have examined the associations between climate and weather conditions and cataract in older populations. We aimed to investigate the associations of air relative humidity and temperature with cataracts in older adults in China.MethodsWe used the cohort data from 2002, 2005, 2008, 2011, 2014, and 2018 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). A total of 62,595 Chinese older adults aged between 65 and 105 years were included in the analyses. City-level annual average air humidity and temperature during 2001 and 2017 (before the survey year) was used to measure population exposure. A cataract was self-reports based on the medical record or the doctor's diagnosis and 8,071 older adults had cataract. Covariates included socio-demographic, health status, lifestyles, and chronic conditions. We adopted the Generalized estimation equation (GEE) model to analyze the associations of relative humidity and temperature with cataracts.ResultsWe found that the average relative humidity (OR: 0.99; 95% CI: 0.98–0.99) in the past year was inversely associated with cataract likelihoods in older adults and a positive association between temperature (OR: 1.04; 95%CI: 1.03,1.05) in the past year and cataract likelihoods in older adults. The associations were robust in stratified analyses by sex, urban/rural residence, and education level. Furthermore, we found a nonlinear J-shaped relationship between temperature and cataract prevalence.ConclusionOur findings provide the evidence that higher temperature and low relative humidity may be associated with cataracts in older adults.
The Effect of Dexmedetomidine on Postoperative Nausea and Vomiting in Patients Undergoing Thoracic Surgery-A Meta-Analysis of a Randomized Controlled Trial
Authors: Zhang Wei , Wang Ruohan , Li Bing , Zhao Ying , Liu Xinmin , Yuan Jingli 
Published: March 2022

BackgroundDexmedetomidine reduces the occurrence of postoperative nausea and vomiting (PONV); however, the effect of dexmedetomidine on PONV in patients undergoing thoracic surgery remains inconclusive. In addition, the effect of different dexmedetomidine application methods, anesthetics, and surgical procedures on the effects of dexmedetomidine on PONV remains unclear. Therefore, the purpose of this meta-analysis was to study the effect of dexmedetomidine on PONV in patients undergoing thoracic surgery.MethodsElectronic databases were searched to identify randomized controlled trials studying the effects of dexmedetomidine on nausea and vomiting after thoracic surgery. In total, 12 articles that met the inclusion criteria were obtained. The primary outcome of this comprehensive analysis was the incidence of PONV; secondary outcomes included the incidence of postoperative nausea, the incidence of postoperative vomiting, postoperative visual analog score (VAS), the amount of intraoperative sufentanil, and the number of times postoperative salvage analgesia was administered.ResultsTwelve trials involving 905 participants undergoing thoracic surgery were included. Compared with placebo, dexmedetomidine reduced the incidence of nausea and vomiting after thoracic surgery [12 trials; 905 participants; risk ratio (RR) = 0.32; 95% CI (0.23, 0.44); P &lt; 0.00001, I2 = 0%]. The subgroup analysis revealed that dexmedetomidine reduces the occurrence of PONV in both thoracotomy and thoracoscopic surgery. In addition, both intravenous and local infusion of dexmedetomidine can reduce the occurrence of PONV, and intravenous or inhaled anesthetics do not affect the effect of dexmedetomidine on reducing PONV. Dexmedetomidine can reduce the postoperative resting VAS of patients, and no statistically significant differences in the amount of intraoperative sufentanil and the number of salvage analgesia procedures after surgery were noted.ConclusionCompared with placebo, dexmedetomidine can reduce the occurrence of PONV in patients undergoing thoracic surgery, and this effect is not affected by the method of dexmedetomidine administration, use of minimally invasive surgery, and use of a combination of intravenous or inhalation anesthetics.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/#myprospero, PROSPERO, identifier: CRD42021269358.
Comprehensive Analysis of Microsatellite-Related Transcriptomic Signature and Identify Its Clinical Value in Colon Cancer
Authors: Luo Rui , Li Yang , Wu Zhijie , Zhang Yuanxin , Luo Jian , Yang Keli , Qin Xiusen , Wang Huaiming , Huang Rongkang , Wang Hui , Luo Hongzhi 
Published: March 2022

BackgroundMicrosatellite has been proved to be an important prognostic factor and a treatment reference in colon cancer. The transcriptome profile and tumor microenvironment of different microsatellite statuses are different. Metastatic colon cancer patients with microsatellite instability-high (MSI-H) are sensitive to immune checkpoint inhibitors (ICIs), but not fluorouracil. Efforts have been devoted to identify the predictive factors of immunotherapy.MethodsWe analyzed the transcriptome profile of different microsatellite statuses in colon cancer by using single-cell and bulk transcriptome data from publicly available databases. The immune cells in the tumor microenvironment were analyzed by the ESTIMATION algorithm. The microsatellite-related gene signature (MSRS) was constructed by the least absolute shrinkage and selection operator (LASSO) Cox regression based on the differentially expressed genes (DEGs) and its prognostic value and predictive value of response to immunotherapy were assessed. The prognostic value of the MSRS was also validated in another cohort.ResultsThe MSI-H cancers cells were clustered differentially in the dimension reduction plot. Most of the immune cells have a higher proportion in the tumor immune microenvironment, except for CD56 bright natural killer cells. A total of 238 DEGs were identified. Based on the 238 DEGs, a neural network was constructed with a Kappa coefficient of 0.706 in the testing cohort. The MSRS is a favorable prognostic factor of overall survival, which was also validated in another cohort (GSE39582). Besides, MSRS is correlated with tumor mutation burden in MSI-H colon cancer. However, the MSRS is a barely satisfactory factor in predicting immunotherapy with the area under the curve (AUC) of 0.624.ConclusionWe developed the MSRS, which is a robust prognostic factor of overall survival in spite of a barely satisfactory immunotherapy predictor. Further studies may need to improve the predictive ability.
A Particle Size Distribution Model for Tailings in Mine Backfill
Authors: Li Zongnan , Guo Lijie , Zhao Yue , Peng Xiaopeng , Kyegyenbai Khavalbolot 
Published: March 2022

With the increasing awareness of sustainable mining, the cement tailings backfill (CTB) method has been developed rapidly over the past decades. In the CTB technique, the two main mechanical properties engineers were concerned with are the rheological properties of CTB slurry and the resulting CTB strength after curing. Particle size distribution (PSD) of tailings material or PSD of the slurry is a significant factor that highly influences the rheological of CTB slurry and the strength performance of CTB. However, the concentrically partial size distribution curve and existing mathematical model could not represent the PSD of tailings material. In this study, a mathematical model for the particle size distribution of mine tailings was established using three model coefficients A B and K, which mainly reflect the characteristics of particles from three aspects respectively, the average size of particles, the proportion of the coarse or the fine parts of particles, and the distribution width of particles; meanwhile, an optimal coefficient solution method based on error analysis is given. Twelve tailing materials sourced from metal mines around China were used for the model establishment and validation. The determination coefficient of error analysis (R2) for all twelve modeled PSD lognormal curves was more significant than 0.99, and the modeled PSD lognormal curves are highly consistent with the determined particle size distribution curve.
Tipos de mantenimiento en las unidades de medición de producción de pozos petroleros
Authors: Medina Roger 
Published: March 2022

El propósito de la investigación fue identificar los tipos de mantenimiento aplicados a las unidades de medición de producción de pozos petroleros. La investigación fue descriptiva, con un diseño de campo, no experimental-transeccional. La población estuvo conformada por cinco superintendentes y diez supervisores, todos del área de mantenimiento, que laboran en las distintas Unidades de Producción que conforman el Distrito Lago Sur de la industria petrolera. Para la recolección de los datos se empleó la técnica de la encuesta, mediante la aplicación de un instrumento tipo cuestionario, conformado por 7 ítems con escala de frecuencia. La validez se realizó a través del juicio de cinco expertos, y para calcular su confiabilidad se empleó el método del Coeficiente Alfa de Cronbach, cuyo valor obtenido fue de 0,84. El análisis de los datos se realizó mediante la estadística descriptiva, a través del estudio de la media aritmética. Se determinó la aplicación del mantenimiento correctivo y una debilidad de la estructuración y aplicación de planes de los mantenimientos preventivo y predictivo.
Aplicación del Capital Asset Pricing Model para conocer el Beta dentro del mercado ecuatoriano
Authors: Terán Guerrero Fernando Neptalí , García Paredes Nery Elisabeth , Vizcaino Villavicencio Viviana de Lourdes , Carranza Guerrero Mirian Noemi 
Published: March 2022

This research develops the Capital Asset Pricing Model (CAPM), which is one of the most used and examined models in finance. For the application of this model, a sample of two shares considered in the ECUINDEX index within the Ecuadorian stock market for the period 2016-2020 was obtained, to find the Beta for an investor in Ecuador. In this model, it is calculated taking into account variables such as the expected profitability, risk of the actions, and that the portfolio finds the appropriate Beta to make the investments, thus providing a useful tool when investing in the Ecuadorian financial market. The investigation is of a correlational type and a portfolio will be formed that will be made up of the shares of Cervecería Nacional, Corporación Favorita, which were able to obtain the information on the price of the shares and achieving results where the Beta minimizes the risk in the best way. is the Favorite Corporation with a ? = 1.9701, with a Ra = 4.92% and Cervecería Nacional with a ? = 0.0517, with a Rb = 1.52% within the Ecuadorian stock market. And the value of the portfolio was obtained at ? = 1.0111, with Rp = 3.22%, so we are balancing risk and return to make an investment in these securities. The market risk premium is equal to 0.0177.
Prospek Masa Depan Bank Syariah di Indonesia Pasca Pemergeran Bank-Bank Syariah BUMN
Authors: Kurniasari Eka 
Published: March 2022

The progress of Islamic banking is a parameter for the sustainability of the sharia economy, Sharia Bank has a very important function, namely as a collection and distribution of funds to the public based on Islamic religious law, the sharia banking division, namely BRI Syariah, Mandiri Syariah and BNI Syariah is expected to be able to boost the existence of Islamic banks whose existence is very far behind when compared to Conventional Banks. The purpose of this study is to analyze the development of Islamic banking in Indonesia after the three sharia bank margins. The method used in this study is analysis. The role of the Sharia Bank has received full attention from the government and is expected to be able to strengthen the national economy and contribute as an international bank.
Histomorphometric effects of Raphanus Sativus leaf extract on Carbon Tetrachloride induced hepatotoxicity
Authors: Ahsan Aslam  , Muhammad Saleh  , Farzana Rahim Memon  , Sadia Khan  , Soobia Pathan  , Kazbano Ramsha  
Published: March 2022

Background: Raphanus sativus is a cruciferous plant which possess free radical scavenging properties that defend the body against the deleterious effects of reactive oxygen species. To evaluate the protective role of Raphanus sativus in CCl4-induced hepatotoxicity through assessment of liver function and oxidative stress markers in albino Wistar rats.
Material and Methods: Quasi-experimental study was conducted from September 2019 to March 2020 at the Postgraduate Research Laboratory, Isra University, Hyderabad. Non-random purposive sampling was used for selecting Albino Wistar rats. All rats were then divided equally into three different groups: Group A (control group), Group B (CCl4 experimental group), and Group C (CCl4 plus Raphanus sativus group). Blood samples were collected through cardiac puncture followed by hepatic histopathological analysis using light microscope. Data was analyzed using SPSS version 24, with ANOVA and Post hoc Tukey analysis used for comparison of different study variables.
Results: Statistically significant rise relative liver weight of group B rats compared with the group A and C rats (P <.05). Moreover, statistically significant (P <0.05) rise in serum markers of hepatic functions was observed after CCl4 administration in Group B. Treatment with Raphanus Sativus administration significantly reduced serum levels of LFTs (p<0.05). There was a significant decline in the plasma levels of oxidative markers in group B while marked histopathological changes like necrosis, sinusoidal dilatation and congestion observed among animals of group B.
Conclusion: Raphanus Sativus exerts an anti-oxidative, anti- and hepatoprotective effect against CCl4-induced hepatic tissue damage.