Cardiometabolic predictors of quantitative high-risk plaque features in a diverse patient population
Authors: Arce J , Kuno T , Fattouh M , Sarkar S , Skendelas J , Daich J , Schenone A , Zhang L , Slomka P J , Shaw L J , Williamson E , Berman D S , Garcia M J , Dey D , Slipczuk L 
Published: October 2022

Abstract

Background/Introduction
Little is known about the prevalence of high-risk plaque features or cardiometabolic predictors in diverse patient populations with underrepresented minorities, in the setting of stable chest pain.

Purpose
The goals of our study are to 1) describe plaque characteristics in a diverse patient population with underrepresented minorities and 2) characterize cardiometabolic risk factors associated with high prevalence of high-risk quantitative low attenuation noncalcified plaque (LDNCP) burden.

Methods
Our study included patients with chest pain undergoing CCTA between June 2016 and October 2021 for stable chest pain, who had a complete cardiometabolic panel including lipoprotein(a) and lipid panel, and at least one blood pressure recording before CCTA. Patients with prior PCI or CABG where excluded. CACS was performed before CCTA as per Agatston method and quantified in Agatston Units (AU). Stenosis was graded as per SCCT guidelines by cardiologists and radiologists with level 3 cardiac CT expertise. Plaque measurements were performed using previously validated semiautomated software (AutoPlaque version 2.5) in all patients with CAD-RADS &gt;0 by expert readers blinded from patients' characteristics. Coronary atherosclerotic plaque volumes were measured. Independent predictors for plaque on CCTA among patients were examined using Wilcox multivariate logistic regression.

Results
A total of 227 consecutive patients were included in our study (see table; age 55.00 [47.50–62.00] years, 63% female, 16% diabetes, 44% hypertension, 40% hyperlipidemia and 32% with current or previous smoking history). Majority of patients were Hispanic (64%) and the rest were Black (27%), White (6%) and Asian (3%).
Patients with LDNCP burden &gt;4% were older (60.00 [52.00–66.50] vs 53.00 [43.75–61.00]; p&lt;0.001), more likely to be diabetic (27.7 vs 11.5%; p=0.005), hypertensive (67.7 vs 33.8%; p&lt;0.001), hyperlipidemic (64.6 vs 29.9%; p&lt;0.001) and present smokers (31.3 vs 13.9%; p=0.003). Almost all patients (63/67) with LDNCP burden &gt;4% had non-obstructive disease (CAD-RADS&lt;4).
Patient with LDNCP burden &gt;4% were more likely to be on statin therapy (46.0 vs 30.4%; p=0.041). There was no differences in ethnicity, hemoglobin A1C, TC, LDL-C, HLD-C, TGs, lipoprotein(a), SBP or DBP.
By logistic regression analysis, age (OR [CI]: 1.06 [1.01–1.08]), hypertension (2.20, [1.06–4.63]) and hyperlipidemia (2.73 [1.37–5.47]) increased the likelihood of LDNCP burden &gt;4%, but not Lipoprotein (a)&gt;175 nmol/L (OR [CI]: 1.07 [0.48–2.31].

Conclusions
In our cohort of patients with high number of unrepresented minorities presenting with stable chest pain, almost all patients (94%) with LDNCP burden &gt;4% had non-obstructive CAD (CAD-RADS&lt;4). There were no differences in prevalence of LDNCP or CAD-RADS among different ethnic groups. Age, hypertension and hyperlipidemia, were the cardiometabolic factors related to LDNCP burden &gt;4%.

Funding Acknowledgement
Type of funding sources: None.