bluuebunny/crossref_metadata_2025_split huggingface dataset:
To estimate the prevalence of thrombocytopaenia and its role as prognostic marker in patients of paediatric intensive care unit
Authors: Joshi Gurudutt , Budh Hetal 
Published: May 2022

Objectives:
Platelets play an important role in normal homeostasis and thrombus formation. They help in reducing vascular permeability, mediating inflammatory processes, promoting wound healing and host defence mechanisms. The aim of this was to estimate the prevalence of thrombocytopaenia, to categorise thrombocytopaenia according to the severity and to evaluate the role of thrombocytopaenia as a prognostic marker in patients admitted in PICU.

Materials and Methods:
This was a prospective observational study over a period of 15 months. One hundred and eighty patients of age 1 month–17 years, critically ill, admitted in PICU or transferred from paediatric ward were enrolled. Those, who had thrombocytopaenia during admission or during PICU stay, were labelled as ‘Thrombocytopaenia’ group, while the remaining patients who did not have thrombocytopaenia were grouped as ‘No thrombocytopaenia’ group.

Results:
The prevalence of thrombocytopaenia in PICU was 37.78% category wise, 35.29%, 33.82%, 19.12% and 11.76% of patients had mild, moderate, severe and very severe thrombocytopaenia, respectively. Mean duration of stay in PICU was more with severe and very severe thrombocytopaenia, followed by moderate and mild thrombocytopaenia, which was statistically significant (P = 0.00037). Mortality was higher in thrombocytopaenic group as compared to non-thrombocytopaenic patients expired, which was statistically significant (P = 0.001013).

Conclusion:
The prevalence of thrombocytopaenia in this study was similar to other studies. Severity of thrombocytopaenia correlated well with the duration of PICU stay. Overall mortality was 22.22% in this study.
Gender Gap or Gender Differences? Gender and Political Participation in Canada
Authors: Houle Nicole 
Published: May 2022

Unequal participation in certain types of political engagement creates unequal influence on political and civil matters (Boulianne, 2022). Studies find that men and women tend to do a similar amount of political participation, with women engaging in more private and flexible forms, and men participating in more direct and collective forms (Bode, 2017; Coffé & Bolzendahl, 2010; Van Duyn et al., 2019; Pfanzelt & Spies, 2019). However, more data is needed when considering Canadian trends, especially when it comes to the causes of these trends. In this study, I conduct statistical analysis of secondary data from a February 2021 Canadian survey (n=1,568) designed by Dr. Shelley Boulianne. I determine which forms of political participation have gendered participation gaps and whether or not these are related to conflict avoidance tendencies and having political female role models. I find few gender differences in political participation. Some small gender differences persist in online forms of political participation, such as signing petitions online and commenting on news sites. Men were more likely post comments on news sites, compared to women; women more likely to sign online petitions, compared to men. As such, political participation moves online, the gender gap may be reproducing itself in online spaces.
Mir-556-3p Inhibits SqCLC via NUAK1
Authors: Cai Yini , Fang Ming , Yao GongJi , Liao Lingmin , Huang Long 
Published: May 2022

ABSTRACT

Background:
MicroRNAs (miRNAs) play a key role in the development of lung cancer; however, there has been little research on the role of miR-556-3p. The present study focused on the function and mechanism of miR-556-3p in lung squamous cell carcinoma (SqCLC).

Methods:
The Cancer Genome Atlas (TCGA) database was searched to analyze the expression of miR-556-3p in SqCLC, and its relationship with prognosis and survival. Quantitative real-time reverse transcription PCR was used to detect the expression difference of miR-556-3p in normal lung epithelial cells (BEAS-2B) and SqCLC cells (H226 and SK-MES-1). The proliferation, migration, and invasion of H226 and SK-MES-1 cells were detected by Cell Counting Kit-8 (CCK-8), wound healing, and Transwell assays, respectively, after transfection with miR-556-3p-mimics. The changes in the levels of key proteins in the epithelial-mesenchyme transition (EMT) signaling pathway were detected using western blotting. Bioinformatic analyses predicted the target gene of miR-556-3p, which was verified using luciferase reporter gene assays. The role of miR-556-3p in SqCLC was verified in a nude mouse tumorigenesis model.

Results:
Analysis of 523 patients with SqCLC in the TCGA database showed that the overall survival (OS) of patients with high miR-556-3p expression was significantly better than that of patients with low miR-556-3p expression (P < 0.05). Compared with that in BEAS-2B cells, miR-556-3p expression was downregulated in H226 and SK-MES-1. After transfection with a miR-556-3p-mimic, CCK-8 analysis showed that the proliferation rate of H226 and SK-MES-1 cells decreased by 66.6% and 60.1% compared with that of the control group. Wound healing assays showed that the migration ability of H226 and SK-MES-1 overexpressing miR-556-3p cells decreased significantly compared with the control group (P < 0.05). Transwell assays showed that the invasion ability of H226 and SK-MES-1 cells overexpressing miR-556-3p was also significantly reduced compared with that the control group (P < 0.05). Western blotting showed that E-Cadherin levels were significantly upregulated after transfection of H226 and SK-MES-1 cells with the miR-556-3p-mimic, while N-cadherin and Vimentin levels were significantly downregulated. Luciferase reporter assays showed that miR-556-3p could bind to the promoter region of NUAK1 (encoding NUAK family kinase 1), and the exogenous expression of NUAK1 could reverse the migration and invasion inhibition by miR-556-3p on H226 and SK-MES-1 cells. In vivo experiments showed that miR-556-3p also inhibited tumor growth.

Conclusions:
MiR-556-3p inhibits EMT by targeting NUAK1, thus inhibiting the migration and invasion of SqCLC. Thus, miR-556-3p might be developed as a target to treat SqCLC.
ANALISA PRODUKTIVITAS PRIMER SEBAGAI UPAYA PENGELOLAAN KUALITAS AIR DI WADUK JATIBARANG, SEMARANG
Authors: Putrisia Agata Virelia , Ain Churun , Rahman Arif 
Published: May 2022

Jatibarang Reservoir is a reservoir located in Semarang City, Central Java which has various benefits for the community and the surrounding area such as a water resource, flood control, tourist attractions, and a hydroelectric power plant. The development of human activities in the Jatibarang Reservoir will affect water quality and water fertility. Therefore, it is necessary to manage water quality through monitoring the primary productivity of the Jatibarang Reservoir. This research aims to determine the primary productivity of the Jatibarang Reservoir through the dark bottle and light bottle method approaches. The research was carried out in July 2020. The research method used is descriptive non-experimental method and the determination of the sampling point using purposive sampling method. Sampling was carried out at five stations with two repetitions. Analysis of primary productivity data using dark bottle and light bottle method. The results showed that the primary productivity of Jatibarang Reservoir ranged from 249,96-1.250.04 mg C/m3/day. Based on the results of the primary productivity, the fertility of the Jatibarang Reservoir is mesotrophic-eutrophic.

ABSTRAK
Waduk Jatibarang merupakan waduk yang berada di Kota Semarang, Jawa Tengah yang memiliki berbagai manfaat untuk masyarakat dan daerah sekitar seperti sebagai sumber air, pengendali banjir, tempat wisata, dan Pembangkit Listrik Tenaga Air (PLTA). Berkembangnya aktivitas manusia di Waduk Jatibarang akan mempengaruhi kualitas air dan kesuburan perairan. Oleh karena itu, dibutuhkan pengelolaan kualitas air melalui monitoring produktivitas primer Waduk Jatibarang. Penelitan ini bertujuan untuk mengetahui produktivitas primer Waduk Jatibarang melalui pendekatan metode botol gelap dan botol terang. Penelitian dilaksanakan pada bulan Juli 2020. Metode penelitian yang digunakan yaitu metode deskriptif non-eksperimental dan penentuan titik pengambilan sampel menggunakan metode purposive sampling. Pengambilan sampel dilakukan di lima stasiun dengan dua kali pengulangan. Analisa data produktivitas primer menggunakan metode botol gelap dan botol terang. Hasil penelitian menunjukkan bahwa produktivitas primer Waduk Jatibarang berkisar antara 249,96-1.250,04 mg C/m3/hari. Berdasarkan hasil produktivitas primer tersebut, kesuburan Waduk Jatibarang yaitu mesotrofik-eutrofik.
Población y sostenibilidad territorial de los espacios rurales en España y Portugal
Authors: Jurado Almonte José Manuel , Pazos García Francisco José 
Published: May 2022

En la Península Ibérica asistimos a múltiples cambios en los espacios rurales, siendo los más evidentes, en muchos casos, una prolongada pérdida y envejecimiento poblacional que pone en riesgo su sostenibilidad ambiental, demográfica y social. En las últimas décadas se han llevado a cabo múltiples políticas e inversiones para contrarrestar estas tendencias, cuyos resultados se han mostrado incapaces de frenar el despoblamiento, abandono de actividades y pérdida de patrimonio cultural (material e inmaterial) y paisajístico. El panorama demográfico del medio rural del interior peninsular y áreas fronterizas (Raya ibérica) es muy preocupante. La disminución poblacional y el envejecimiento de refuerzan con la pérdida de servicios, e inciden en el abandono de actividades y un menor atractivo frente a los territorios urbanos, tornándose en incapaces para fijar siquiera su actual población.
Estas circunstancias justifican esta investigación. El elemento conductor ha sido la evolución reciente y características de la población y poblamiento. El ámbito de estudio son los dos países ibéricos, España y Portugal, con notables semejanzas geográficas e históricas y con una frontera extensa y antigua. Para ello se ha utilizado una base de datos de escala municipal con datos demográficos (INE) georreferenciados con el apoyo de un SIG.
Jovens em condições de vulnerabilidade social: fatores que auxiliam o desenvolvimento da resiliência
Authors: Fagundes Maria Aparecida , Cunico Furlanetto Ecleide 
Published: May 2022

O presente artigo pauta-se em pesquisa que teve como objetivo: compreender quais fatores favorecem o desenvolvimento da resiliência em jovens em situação de vulnerabilidade social. Os principais autores que deram suporte à investigação foram Furlanetto, Passeggi e Souza, no campo da pesquisa (Auto)biográfica. Por sua vez, Cyrulnik; Yunes; Cassol e Antoni) permitiram aprofundar o conceito de resiliência. A Pesquisa (Auto)biográfica deu sustentação metodológica ao estudo que se apoiou na entrevista narrativa para a produção de dados. Participaram da pesquisa jovens que vivem em situação de vulnerabilidade social egressos de uma Organização não Governamental (ONG), situada numa comunidade em São Paulo. Com base na análise dos dados, é possível dizer que os jovens se apropriaram muito bem dos vínculos afetivos com a família. Entre os participantes, a maioria reconhece o papel fundamental da mãe, que lhes apresentou os valores basilares. Ao refletir sobre o papel da escola e dos professores, os jovens demonstram ter assimilado a representação do espaço escolar como local de aprendizado e também dos vínculos, tanto com os colegas quanto com os professores, que lhes proporcionaram afeto e apoio. Além disso, foram mencionados os benefícios do esporte como apoio psicológico.
Environmental-Friendly and Non-Toxic TBSI as an Alternative for MOR Accelerator
Authors: Rethan Kiru , Sanjaya Amitha , Patabendige Chami N. K. 
Published: May 2022

In the solid tyre rubber industry, most accelerators can produce n-nitrosamines as a by-product during the vulcanization process. As many n-nitrosamines are carcinogenic, they are highly regulated in final rubber articles and during manufacturing process. 2-(Morpholinothio benzothiazole (MOR) is the primary accelerator used in vulcanizing systems. It produces nitrogen toxic gases (nitrogen oxide and amine gas) which are carcinogenic. In this research MOR was successfully replaced with N-tert-butyl-2-benzothiazole sulfenimide (TBSI) accelerator which has no carcinogenic effect. The main objective of this research is to maintain its original properties while replacing MOR with TBSI accelerator. This study was conducted and test samples were made of bonding rubber compound that is used to make the bonding layer of tyres which is the common part in all type of solid tyres. Physical-mechanical and bonding properties were analyzed for MOR and TBSI added bonding compound samples. Tensile, hardness, density and rheological using Oscillating die rheometer properties were also measured to maintain the quality of the tyre. The property change of bond layer can affects the other tyre layers. So, it can lead to failure of curing process or failure in performance of the tyre during the applications. The TBSI curing characteristics are closer to MOR sample. However other physical properties like hardness and density of TBSI samples were bit lower but they were in the required level as a bonding layer compound. Substitution of MOR by ‘safe TBSI’ compounds are still active as accelerators, but do not form carcinogenic gases.
Methods of development and evaluation of movement qualities of senior school students in physical culture lessons in football
Authors: Sinigovets V. , Sinigovets L. , Diskovsky V. 
Published: May 2022

Methods of development and assessment of motor skills in physical education lessons for students are the main factor in obtaining information about the state of their physical fitness. Pedagogical control over the level of development of motor skills of high school students in physical education lessons in football helps to improve the management of the educational process, making adjustments to the planning of physical education and forecasting academic achievements. The main stages of the process of developing evaluation criteria for the manifestation of motor skills include: 1) the correct choice of control and selecti on of motor tests, which must meet the metrological criteria of reliability, objectivity and informativeness; 2) compliance of methods and means of control with the objectives of the study; 3) the adequacy of methods of statistical processing of the results of pedagogical control.
The purpose of the study is aimed at introducing into the educational process of high school students means of developing motor skills and developing assessment criteria for physical fitness of high school students in physical education lessons.
The scientific novelty is to develop quantitative and qualitative criteria for assessing the physical fitness of high school students in football lessons, to determine the impact of implemented tools and the dynamics of their changes in the results of phased control. The introduced method of development and assessment of motor qualities of high school students allows to promote the implementation of individual and differential approach in the process of physical education.
Anterior cranial fossa osseous arteriovenous fistula of the crista galli with bone erosion: patient series
Authors: Matsubara Shunji , Takai Hiroki , Enomoto Noriya , Hara Keijiro , Hirai Satoshi , Sunada Yoshihiro , Yamada Shodai , Tao Yoshifumi , Ogawa Yukari , Yagi Kenji , Uno Masaaki 
Published: May 2022

BACKGROUND
Although an anterior cranial fossa dural arteriovenous fistula (ACFdAVF) is thought to have a fistula on the dura near the olfactory groove, the detailed angioarchitecture remains unreported.

OBSERVATIONS
In case 1, a 65-year-old man was found to have an asymptomatic ACFAVF. His computed tomography angiography (CTA)-maximum intensity projection (MIP) showed the shunt point in the crista galli (CG), with the intradural drainer penetrating the destroyed bone of the CG. In case 2, a 78-year-old man had a past history of intracerebral hemorrhage and was found to have an ACFAVF. The rotational angiography (RA)-MIP showed the intraosseous fistula in the CG with the drainer passing through a tiny bone defect of the CG. In case 3, a 35-year-old man was investigated for epilepsy. The RA-MIP showed an osseous arteriovenous fistula (AVF) in the anterior cranial base, with the drainer penetrating the skull osteolytic site. In case 4, a 73-year-old woman was found to have an asymptomatic ACFAVF. Her RA-MIP showed the osseous AVF with the drainer penetrating the CG with bone erosion.

LESSSONS
All patients were diagnosed with anterior cranial fossa osseous AVF rather than dAVF, with bone erosion in the CG. These findings should be noted at the time of diagnosis and treatment.
EVALUASI PROGRAM “KEMBARA” SEBAGAI UPAYA DASAR PENINGKATAN PROGRAM PEMBELAJARAN BAHASA ARAB DI UNIVERSITAS DARUSSALAM GONTOR
Authors: Mujahid Imam , Nasiruddin Muhammad , Hudayana Kartika 
Published: May 2022

ABSTRAKTujuan dari penelitian ini adalah untuk mendeskripsikan evaluasi program Kembara Bahasa Arab di Universitas Darussalam Gontor Ponorogo. Penelitian ini menggunakan pendekatan kualitatif dengan menggunakan metode deskriptif analisis. Hasil penelitian menunjukkan bahwa 1) Proses pembelajaran terdiri dari persiapan, pelaksanaan, dan evaluasi, 2) Problematika pembelajaran Bahasa Arab pada program Kembara Bahasa Arab terdiri dari beberapa faktor antara lain faktor peserta yang terdiri dari latar belakang pendidikan peserta, motivasi, kesulitan berbicara bahasa Arab dan kurangnya kosakata, 3) Evaluasi dan solusi dari problematika pada proses pembelajaran Bahasa Arab pada program Kembara Bahasa Arab yaitu untuk peserta dengan cara selalu mempraktikkan kosa kata yang telah dihafal dan menyempatkan diri untuk mengikuti kegiatan kelompok belajar bahasa Arab. Oleh karena itu, dapat ditarik kesimpulan bahwa program pembelajaran “Kembara” sudah cukup baik dan sesuai dengan indikator pembelajaran yang baik, meskipun ada beberapa problematika yang perlu diperhatikan dan dicarikan solusi agar program pembelajaran dapat lebih baik. Saran untuk peneliti selanjutnya adalah dengan melakukan penelitian lain yang membahas mengenai evaluasi program pembelajaran lain. Kata Kunci: Evaluasi, pembelajaran, bahasa Arab, program kembara, mahasiswa ABSTRACTThe purpose of this study is to describe the evaluation of the Arabic Language Tour program at Darussalam University, Gontor Ponorogo. This study uses a qualitative approach using descriptive analysis method. The results showed that 1) The learning process consisted of preparation, implementation, and evaluation, 2) The problems of learning Arabic in the Arabic Language Tour program consisted of several factors, including participant factors consisting of participants' educational background, motivation, difficulty speaking Arabic. and lack of vocabulary, 3) Evaluation and solutions to problems in the Arabic learning process in the Arabic Language Tour program, namely for participants by always practicing memorized vocabulary and taking the time to take part in Arabic learning group activities. Therefore, it can be concluded that "Kembara" learning program is quite good and in accordance with good learning indicators, although there are some problems that need to be considered and solutions are found so that the learning program can be better. Suggestions for further researchers is to conduct other research that discusses the evaluation of other learning programs.Keywords: Evaluation, learning Arabic, Arabic, traveling programs, students
ADAPTASI BUDAYA BELAJAR MASA PANDEMI COVID 19 DI SEKOLAH DASAR KABUPATEN SINTANG
Authors: Dike Daniel , Parida Lusila , Serani Gabriel 
Published: May 2022

ABSTRAKPandemi Covid 19 merupakan situasi yang menantang bagi sekolah untuk meningkatkan sistem teknologi digital untuk beradaptasi dengan kebutuhan belajar mengajar secara online. Penelitian ini bertujuan memetakan gambaran kesiapan pembelajaran adaptif masa pandemi di level sekolah dasar di Kabupaten Sintang. Metode penelitian menggunakan studi kasus di sekolah dasar dengan karakteristik yang berbeda yakni sekolah negeri dan sekolah swasta. Data diperoleh dari hasil observasi, wawancara,dan studi dokumen. Analisis data menggunakan pola induksi interaktif. Hasil penelitian menunjukan bahwa gambaran pendidikan masa pandemi dan post pandemi memperlihatkan tiga aspek kunci yaitu (a) upaya sekolah melakukan adaptasi pembelajaran di saat pandemi dan post pandemi covid 19 (b) upaya sekolah melakukan inovasi pembelajaran, metode dan materi ajar, (c) upaya sekolah menginovasi kebijakan dan program-program sekolah. Menuju institusi pendidikan dan sekolah-sekolah dasar yang mampu beradaptasi dan tahan terhadap perubahan sosial dan alam sekolah disarankan untuk (1) merekonstruksi kembali pendidikan dan pembelajaran yang dilakukan guru di era digital saat ini, (2) melibatkan dan memanfaatkan kecerdasan buatan dalam proses pendidikan dan pembelajaran, (3) membangun pendidikan yang kuat, setara dan berkelanjutan agar adaptif menghadapi perubahan sosial yang terjadi secara global saat ini.Kata Kunci: rekonstruksi pembelajaran, adaptasi pembelajaran ABSTRACTThe Covid19 pandemic is the challenged situation for schools improve digital technology system to adapt with online teaching and learning requirements.This study aims to map a picture of the readiness for adaptive learning during the pandemic at the elementary school level in Sintang district. The research method uses case studies in three schools with different characteristics, namely public schools and private schools.Data obtained from observations, interviews, and document studies. Data analysis using interactive induction pattern. The results show that the description of education during the pandemic and post-pandemic shows three key aspects, namely (a) school efforts to adapt learning during the pandemic and post-covid-19, (b) school efforts to innovate learning, teaching methods and materials, (c) efforts schools innovate school policies and programs. In order for our educational institutions and primary schools to be able to adapt and be strong to social and school changes, it is recommended to (1) reconstruct the education and learning that teachers do in the current digital era, (2) involve and utilize artificial intelligence in the education process and learning, (3) build a strong, equal and sustainable education to deal with social changes that are happening globally today.Keywords: learning reconstruction, learning adaptation