bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vitro longitudinal lumbar spinal cord preparations to study sensory and recurrent motor microcircuits of juvenile mice
Authors: Özyurt Mustafa Görkem , Ojeda-Alonso Julia , Beato Marco , Nascimento Filipe 
Published: May 2022

AbstractIn vitro spinal cord preparations have been extensively used to study microcircuits involved in the control of movement. By allowing precise control of experimental conditions coupled with state-of-the-art genetics, imaging and electrophysiological techniques, isolated spinal cords from mice have been an essential tool in detailing the identity, connectivity and function of spinal networks. The majority of the research has arisen from in vitro spinal cords of neonatal mice, which are still undergoing important postnatal maturation. Studies from adults have been attempted in transverse slices, however, these have been quite challenging due to the poor motoneuron accessibility and viability, as well as to the extensive damage to the motoneuron dendritic trees. In this work, we describe two types of coronal spinal cord preparations with either the ventral or the dorsal horn ablated, obtained from mice of different postnatal ages, spanning from pre-weaned to one month old. These semiintact preparations allow recordings of sensory-afferent and motor-efferent responses from lumbar motoneurons using whole cell patch-clamp electrophysiology. We provide details of the slicing procedure and discuss the feasibility of whole-cell recordings. The in vitro dorsal and ventral horn-ablated spinal cord preparations described here are an useful tool to study spinal motor circuits in young mice that have reached the adult stages of locomotor development.New & NoteworthyIn the past 20 years, most of the research into the mammalian spinal circuitry has been limited to in vitro preparations from embryonic and neonatal mice. We describe two in vitro longitudinal lumbar spinal cord preparations from juvenile mice, that allow the study of motoneuron properties and respective afferent or efferent spinal circuits through whole-cell patch-clamp. These preparations will be useful to those interested in the study of microcircuits at mature stages of motor development.
Single-Cell RNAseq Analysis Reveals Robust, Anti-PD-1-Mediated Increase of Immune Infiltrate in Metastatic Castration-Sensitive Prostate Cancer
Authors: Hawley Jessica E. , Obradovic Aleksandar Z. , Dallos Matthew C. , Lim Emerson A. , Runcie Karie , Ager Casey R. , McKiernan James , Anderson Christopher B. , Decastro Joel , Weintraub Joshua , Virk Renu , Lowy Israel , Hu Jianhua , Chaimowitz Matthew G. , Guo Xinzheng V. , Zhang Ya , Worley Jeremy , Stein Mark N. , Califano Andrea , Drake Charles G. 
Published: May 2022

SUMMARYCompared to other malignancies, the tumor microenvironment (TME) of primary and castration-resistant prostate cancer (CRPC) is relatively devoid of immune infiltrates. While androgen deprivation therapy (ADT) induces a complex immune infiltrate in localized prostate cancer, both in animal models and humans, the TME composition of metastatic, castration-sensitive prostate cancer (mCSPC) is relatively unknown and the effects of ADT and other treatments are poorly characterized in this context. To address this challenge, we analyzed metastatic sites from patients enrolled on a phase 2 clinical trial (NCT03951831), in which men were treated with standard-of-care chemo-hormonal therapy with anti-PD-1 immunotherapy, at the single cell level. Longitudinal protein activity-based analysis of TME subpopulations identified immune subpopulations conserved across multiple metastatic sites, their dynamic, treatment-mediated evolution, and associated clinical response features. Our study revealed a therapy-resistant, transcriptionally distinct tumor subpopulation, which comprises an increasing number of cells in treatment-refractory patients, and identified several druggable targets in both tumor and immune cells as candidates to advance treatment and improve outcomes for patients with mCSPC.
Traditional media or social media? Corporate green media communication and consumer intention to cocreate green value in post-COVID-19 China
Authors: Zhao Li , Sun Jianxin , Zhang Ling , Ma Bowen 
Published: May 2022

PurposeThis study investigated whether there are differences in the effects of green traditional media communication (GTMC) and green social media communication on consumers' intention to cocreate green value (ICGV) in post-COVID-19 China. The authors further tested the chain mediating role of cocreation efficacy and cocreation outcome expectation and the moderating role of perceived CSR image.Design/methodology/approachUsing a survey, we collected a dataset of 683 consumers through stratified random sampling in main shopping malls in four Chinese cities. Structural equation modeling (SEM) was used to test the conceptual framework and hypotheses, and bootstrapping was used to estimate the mediated standardized regression coefficients. Multiple linear regression analysis was used to test the moderating effect.FindingsGTMC, firm-created content (FCC), and user-generated content (UGC) all had positive effects on ICGV. Cocreation efficacy and cocreation outcome expectation had a chain mediation effect in GTMC and ICGV, UGC, and ICGV. Perceived CSR image positively moderated the effects of both GTMC and FCC on ICGV. However, perceived CSR image did not significantly moderate the relationship between UGC and ICGV.Originality/valueThis study contributes to our understanding of the effect of green media communication on consumers' ICGV in post-COVID-19 China. It also develops the concepts of cocreation efficacy and cocreation outcome expectation. Moreover, analyzing the chain mediating role of cocreation efficacy and cocreation outcome expectation in green media communication and ICGV extends social cognitive theory to the context of green value cocreation. Finally, examining the moderating role of perceived CSR image provides a basis for understanding the boundary conditions of green media communication's effect on ICGV.
Relationship between Big Five personality traits and knowledge sharing behaviour: moderating role of Islamic work ethics
Authors: Javaid Mudaser , Jaaron Ayham A.M. , Abdullah Nor Hazana Binti 
Published: May 2022

PurposeThe existence of intense competition in turbulent markets confirms the importance of using ethical employee practices in knowledge sharing behaviour (KSB) to ensure organisational growth. This is especially applicable in developing countries' markets where this intensive competition usually results in organisations following illicit practices. This paper aims to examine the relationship between the Big Five personality traits (i.e. openness to experience, conscientiousness, extraversion, agreeableness, and neuroticism) and KSB using Islamic work ethics (IWE) as the moderator.Design/methodology/approachA quantitative research method using a survey instrument collected 182 responses from employees in the Pakistani telecommunication industry. The partial least squares structural equation model (PLS-SEM) was used to analyse the collected data.FindingsThe results found that IWE has a positive impact on KSB and a positive moderating impact on the relationship between the Big Five personality traits except neuroticism and KSB. Also, openness to experience and agreeableness positively impacted KSB.Practical implicationsThis paper contributes to the field of human resource (HR) management by helping managers in the hiring process or developing employee's personalities. Additionally, policymakers are encouraged to create Islamic values platforms to increase KSB amongst employees.Originality/valueThis study indicates the importance of IWE in boosting the impact of personality on KSB and provides insights into IWE's role in enhancing an organisation's competitive advantages in turbulent markets.
Professionals’ perception studies of vertical greening systems in Lagos, Nigeria
Authors: Olusoga Olawale , Adegun Olumuyiwa 
Published: May 2022

PurposeThe purpose of this study is to explore the perceptions of built environment professionals on the benefits and impediments limiting the widespread acceptance of vertical greening systems (VGSs) in Lagos, Nigeria. This study contributes to the knowledge on the adoption of VGSs from the socio-technical dimension.Design/methodology/approachThe study employed a survey method. An online questionnaire was used to obtain information from the respondents. The questionnaire was divided into four (4) sections. The first section focused on the socio-demographic variables while the second section addressed knowledge of VGSs, willingness to educate clients on the use of VGS and the possibility of VGS improving city image in Lagos. Section three (3) focused on the VGS benefits, subdivided into environmental, economic and aesthetic qualities and measured on a five-point Likert scale. Lastly, section four (4) concentrated on the impediments to the use of VGS in Lagos.FindingsProfessionals are willing to adopt the use of VGSs if their clients agree to the benefits it delivers to occupants, the environment and the building fabric.Originality/valueThis paper fulfills an identified need to study the perceptions of professionals toward VGSs patronage.
You don’t have to tip the human waiters anymore, but … Unveiling factors that influence consumers’ willingness to pay a price premium for robotic restaurants
Authors: Chuah Stephanie Hui-Wen , Jitanugoon Siriprapha , Puntha Pittinun , Aw Eugene Cheng-Xi 
Published: May 2022

Purpose
This study aims to simultaneously examine the influence of demographic, psychographic and situational factors on consumers’ willingness to pay a price premium (WTPp) for robotic restaurants and to profile market segments based on consumers’ WTPp levels (positive, neutral and negative).

Design/methodology/approach
Using an online survey, the data were gathered from a sample of 897 Thai consumers who had dined at a robotic restaurant in the past 12 months. Structural equation modeling, chi-square tests and the one-way analysis of variance were used for data analysis.

Findings
Demographic (gender, age, income and marital status), psychographic (perceived advantages/disadvantages, personal innovativeness and personality traits) and situational factors (perceived health risk and self-protection behavior) significantly influence consumers’ WTPp for robotic restaurants. The positive price premium group differs significantly from the neutral and negative price premium groups in terms of demographic, psychographic and situational profiles.

Practical implications
The findings of this study help restaurateurs target the correct customers and set up appropriate price fences to safeguard profits and maximize return on investment.

Originality/value
This study contributes to the literature on technology-based services and hospitality by heeding the calls made by Ivanov and Webster (2021) and providing much-needed empirical evidence of possible changes in consumers’ WTPp for robot-delivered services in restaurants due to COVID-19.
Contemporaneous causality among residential housing prices of ten major Chinese cities
Authors: Xu Xiaojie , Zhang Yun 
Published: May 2022

Purpose
This study aims to investigate dynamic relationships among residential housing price indices of ten major Chinese cities for the years 2005–2021.

Design/methodology/approach
Using monthly data, this study uses vector error correction modeling and the directed acyclic graph for characterization of contemporaneous causality among the ten indices.

Findings
The PC algorithm identifies the causal pattern and the Linear Non-Gaussian Acyclic Model algorithm further determines the causal path, from which this study conducts innovation accounting analysis. Sophisticated price dynamics are found in price adjustment processes following price shocks, which are generally dominated by the top tiers of cities.

Originality/value
This study suggests that policies on residential housing prices in the long run might need to be planned with particular attention paid to these top tiers of cities.
Going organic or staying traditionalistic? The role of agriculture information system
Authors: Doanh Nguyen Khanh , Quynh Nguyen Ngoc , Pham Thi Tuan Linh 
Published: May 2022

PurposeThe purpose of this study is to examine how use of agriculture information systems could impact farmers' intention to convert from traditional to organic agriculture production in the mountainous areas of Northern Vietnam, based on a research framework developed from integrating Diffusion of Innovation Theory and Theory of Planned Behavior. Specifically, the authors aim to test the direct impact of use of agriculture information systems on converting intention and the interaction between use of agriculture information systems and perceived economic benefits, perceived non-economic benefits of organic production and market access on the formation of converting intention.Design/methodology/approachData were collected from a sample survey that included 634 agriculture-producing households in Thai Nguyen, Tuyen Quang and Cao Bang provinces of Northern Vietnam. The logistic regression was used for data analysis.FindingsResearch findings indicate that perceived economic benefits, non-economic benefits, market access and use of agriculture information systems positively support the converting intention. Moreover, the use of information systems strengthens the links between the converting intention and perceived economic benefits, perceived non-economic benefits and market access.Originality/valueThis research is innovative in incorporating the use of agriculture information systems as both direct contributor and moderator in converting decisions.
Impact of E-commerce adoption on business performance of SMEs in Sri Lanka; moderating role of artificial intelligence
Authors: Fonseka Kapila , Jaharadak Adam Amril , Raman Murali 
Published: May 2022

PurposeWith the rapid development of technology in the 21st century, an ever-growing number of organisations are adopting digitalised technologies. The global economy connected with digitalisation is moving towards sustainable development. Individual firms adopt innovative technological strategies to consolidate their position in the competitive market. The study aimed to examine the management perception of the impact of E-commerce adoption (EC) on business performance (BP) – the moderating role of using artificial intelligence (AI).Design/methodology/approachA quantitative study using the deductive approach and the data collected from senior managers of the small and medium-sized enterprises (SMEs) in Sri Lanka, and 389 samples were collected using a simple random sampling method. EC, BP and AI were named as the independent, dependent and moderating variables in the model. Porters' generic strategies and resource-based views (RBVs) were applied as the foundation of the study.FindingsThe independent and moderating variables significantly influenced the BP. Managers' age, gender, education level and job position affect their perception.Originality/valueThe global economy is moving towards sustainable development using digitalisation. The firms should blend their strategies with digitalised platforms to survive in the competitive market.Peer reviewThe peer review history for this article is available at the following link: https://publons.com/publon/10.1108/IJSE-12-2021-0752
From horizontal to vertical relationships: how online community identification fosters sport fans’ team identification and behavioural intentions
Authors: Kim Sungkyung , Manoli Argyro Elisavet 
Published: May 2022

PurposeWith the remarkable advancements in information and communication technologies, comprehending online sport fan communities is being pushed further up in the agenda of sport teams worldwide. Based on social identity theory, the main purpose of this research paper is to test the mechanism of how horizontal relationships developed through online communities lead to vertical relationships such as team identification and behavioural intentions.Design/methodology/approachUsing a sample of online baseball fan community members in South Korea (N = 400) and employing structural equations modelling, the current research examined the structural relations among online community identification, team identification, behavioural intention and WOM intention while testing moderating effect of perceived authenticity.FindingsThis study finds that online community identification has a significant positive impact on team-level consumer outcomes: team identification, behavioural intention and WOM intention. Team identification is verified as a significant determinant of both behavioural intention and WOM intention. Moreover, the partial mediating role of team identification in the relationships between online community identification and behavioural intentions are corroborated.Originality/valueThe present study furnishes essential information for identifying the underlying mechanism of how fan-to-fan horizontal relationships cultivate team-to-fan vertical relationships in the context of the virtual fan community.
Advancing health-related abilities and behaviors via health apps: a large-scale survey from self-regulation perspective
Authors: Fu Shaoxiong , Fang Jie , Cai Zhao , Lim Eric Tze Kuan , Tan Chee-Wee , Yang Haiping 
Published: May 2022

PurposeMotivated by the need for research on the relationship between health app usage and health-related outcomes in the form of health status and life satisfaction, this study builds on self-regulation theory to construct a research model for elucidating how health app quality affects health information literacy, health app usage and physical activity.Design/methodology/approachTo empirically validate the proposed research model, a large-scale questionnaire survey on health app usage was administered on a sample of 6,948 respondents recruited from a university in China. Structural equation modeling was employed for data analysis.FindingsEmpirical findings demonstrate that health app quality positively affects self-regulation with respect to health app usage, health information literacy and physical activity. Taken together, these self-regulated behaviors drive health-related outcomes for health status and life satisfaction.Originality/valueThis study advances extant literature on health app usage through the application of self-regulation theory to investigate the effects of technological interventions in healthcare. Findings offer practical implications for how health apps can be leveraged to realize positive health-related outcomes.
Diagnosing default syndromes: early symptoms of entrepreneurial venture insolvency
Authors: Modina Michele , Zedda Stefano 
Published: May 2022

PurposeIn this study, a panel of 74,128 Italian SMEs was analyzed to verify whether any syndromes could be identified and defined through financial ratios. Defining relevant syndromes (i.e. the set of correlated signs and symptoms often associated with a particular disorder) can be of importance for assessing which specific intervention can solve a firm's difficulties.Design/methodology/approachTo identify the main syndromes involved in company defaults, firstly, financial data on defaulted firms for each of the main economic sectors were examined through a cluster analysis; the results obtained for each sector were then compared to verify whether syndromes recur across sectors. Finally, the effects of each syndrome were compared with possible default causes, as described by previous literature.FindingsResults show that a significant share of corporate insolvencies is characterized by a set of recurrent signs and symptoms so that the main syndromes can be identified. The results also show that these syndromes recur across sectors, even if specific values characterize each sector.Research limitations/implicationsThe approach adopted in this study sets a new direction for the analysis of default risk, as the study shows that certain key syndromes can be defined and described, and the study suggests that different problems can induce different risk patterns. Further analyses of other samples could confirm whether the same syndromes recur over countries and over time.Originality/valueThis is the first study aimed at identifying and describing the syndromes affecting SMEs, conducted by means of balance-sheet ratios.
Factors affecting online knowledge sharing and its effect on academic performance
Authors: Alyouzbaky Bassam A. , Al-Sabaawi Mohmed Y. Mohmed , Tawfeeq Ahmed Z. 
Published: May 2022

Purpose
This study aims to explore the factors that affect online knowledge sharing among the scientific performance of academics at the University of Mosul, Republic of Iraq.

Design/methodology/approach
Data were collected by using a random sample by means of an electronic questionnaire distributed to 211 academics at the University of Mosul via online platforms. Structural equation modeling was used to test hypotheses using AMOS 24 software.

Findings
The results showed that collaboration, perceived flexibility and willingness to share had a significant effect on online knowledge sharing behavior and that which in turn had an effect on the academic performance of respondents, while the results showed no influence of knowledge self-efficacy and communication on the behavior of online knowledge sharing.

Research limitations/implications
In this research, the effects of five factors on online knowledge sharing behavior were studied, in addition to the effect of the latter on academic performance. The research did not study the effect of the participants’ personal characteristics on the behavior of knowledge sharing online, which could be an area of future investigation. The study was limited to online knowledge sharing for academics working in public universities, and the authors suggest conducting a future study from the perspective of medical staff working in hospitals and its impact on their performance.

Practical implications
Based on the findings of the current study, this study suggests that the academic staff at the University of Mosul and similar universities pay attention to scientific cooperation between researchers and teaching staff, by creating online groups to carry out joint research projects that contribute to sharing knowledge among participants through social media in general and scientific platforms in particular. Establishing a scientific research portal could serve this well for example.

Originality/value
Most previous studies have focused on areas related to knowledge sharing in higher education institutions from the traditional perspective and therefore studies that examine the factors affecting online knowledge sharing among academics are limited, so this study fills this gap. This paper focuses on identifying the scientific benefits for academics through knowledge exchange and the use of electronic platforms at the University of Mosul. The study is expected to contribute to enhance the exchange of knowledge online between academics in similar universities in Asia and Africa due to the convergence of cultures and the nature of the work of these universities, as well as the possibility of generalization due to the research’s use of the deductive method.