bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prospect and challenges of sodium‐ion batteries for low‐temperature conditions
Authors: Wang Meng , Wang Qianchen , Ding Xiangyu , Wang Yingshuai , Xin Yuhang , Singh Preetam , Wu Feng , Gao Hongcai 
Published: June 2022

AbstractIn recent years, considerable attention has been focused on the development of sodium‐ion batteries (SIBs) because of the natural abundance of raw materials and the possibility of low cost, which can alleviate the concerns of the limited lithium resources and the increasing cost of lithium‐ion batteries. With the growing demand for reliable electric energy storage devices, requirements have been proposed to further increase the comprehensive performance of SIBs. Especially, the low‐temperature tolerance has become an urgent technical obstacle in the practical application of SIBs, because the low operating temperature will lead to sluggish electrochemical reaction kinetics and unstable interfacial reactions, which will deteriorate the performance and even cause safety issues. On the basis of the charge‐storage mechanism of SIBs, optimization of the composition and structure of electrolyte and electrode materials is crucial to building SIBs with high performance at low temperatures. In this review, the recent research progress and challenges were systematically summarized in terms of electrolytes and cathode and anode materials for SIBs operating at low temperatures. The typical full‐cell configurations of SIBs at low temperatures were introduced to shed light on the fundamental research and the exploitation of SIBs with high performance for practical applications.
Prospects for managing end‐of‐life lithium‐ion batteries: Present and future
Authors: Wang Xiao‐Tong , Gu Zhen‐Yi , Ang Edison Huixiang , Zhao Xin‐Xin , Wu Xing‐Long , Liu Yichun 
Published: June 2022

AbstractThe accelerating electrification has sparked an explosion in lithium‐ion batteries (LIBs) consumption. As the lifespan declines, the substantial LIBs will flow into the recycling market and promise to spawn a giant recycling system. Nonetheless, since the lack of unified guiding standard and nontraceability, the recycling of end‐of‐life LIBs has fallen into the dilemma of low recycling rate, poor recycling efficiency, and insignificant benefits. Herein, tapping into summarizing and analyzing the current status and challenges of recycling LIBs, this outlook provides insights for the future course of full lifecycle management of LIBs, proposing gradient utilization and recycling‐target predesign strategy. Further, we acknowledge some recommendations for recycling waste LIBs and anticipate a collaborative effort to advance sustainable and reliable recycling routes.
Adherence to cancer prevention recommendations and risk of breast cancer in situ in the United Kingdom Biobank
Authors: Karavasiloglou Nena , Pestoni Giulia , Kühn Tilman , Rohrmann Sabine 
Published: June 2022

AbstractA health‐conscious lifestyle may protect against breast cancer in situ. However, breast cancer in situ is mainly detected by screening, and many studies lack information on screening participation. Thus, we evaluated the association between prediagnostic lifestyle and risk of breast cancer in situ, accounting for screening participation at recruitment. A score reflecting the adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations was constructed, using the recommendations on healthy body weight, physical activity, consumption of plant‐based foods, red and processed meat, alcohol and avoidance of sugar. Cox proportional hazards regression models were used to investigate the association between the lifestyle score and breast cancer in situ risk, while accounting for important confounders. The lifestyle score was not significantly associated with breast cancer in situ risk (HRcontinuous = 0.96, 95% CI = 0.91‐1.03) in the overall cohort. In participants not reporting dietary changes in the past 5 years, the lifestyle score was inversely associated with breast cancer in situ risk (HRcontinuous = 0.92, 95% CI = 0.85‐0.99). In those reporting dietary changes in the past 5 years due to illness or other reasons, the lifestyle score was not associated with breast cancer in situ risk (HRcontinuous = 1.04, 95% CI = 0.94‐1.15). Lifestyle was inversely associated with breast cancer in situ risk in women not reporting recent changes in their dietary habits. This inverse association is consistent with inverse associations reported in previous studies. Our findings suggest that breast cancer in situ and invasive breast cancer share a similar risk factor profile.
Interactions Between Peptide Assemblies and Proteins for Medicine
Authors: Mañas‐Torres Mari C. , Illescas‐Lopez Sara , Gavira José A. , de Cienfuegos Luis Álvarez , Marchesan Silvia 
Published: June 2022

AbstractPeptide assembly is attractive not only to develop biotechnological tools and smart nanomaterials, but also to treat pathologies in new ways. This Review focuses on recent progress made in the exciting area pertaining the interaction between peptide assemblies and proteins. Earlier works aimed to identify proteins able to bind peptide assemblies for therapeutics’ delivery and biocompatible scaffolds. Recent advancements cover more applications that go beyond tissue regeneration and biomaterials. On one hand, self‐assembling peptides interacting with proteins can inhibit pathological amyloid fibrillation, or boost the immune response to vaccines. On the other, they have been exploited to promote protein crystallization, also for therapeutics’ delivery. As research advances in this exciting area, it opens the way towards a qualitative leap in the clinical translation of supramolecular medicinal chemistry to creatively tackle unmet challenges of modern disease treatment and prevention.
Dynamics, gene transfer, and ecological function of intracellular and extracellular DNA in environmental microbiome
Authors: Ye Mao , Zhang Zhongyun , Sun Mingming , Shi Yu 
Published: June 2022

AbstractExtracellular DNA (eDNA) and intracellular DNA (iDNA) extensively exist in both terrestrial and aquatic environment systems and have been found to play a significant role in the nutrient cycling and genetic information transmission between the environment and microorganisms. As inert DNA sequences, eDNA is able to present stability in the environment from the ribosome enzyme lysis, therein acting as the historical genetic information archive of the microbiome. As a consequence, both eDNA and iDNA can shed light on the functional gene variety and the corresponding microbial activity. In addition, eDNA is a ubiquitous composition of the cell membrane, which exerts a great impact on the resistance of outer stress from environmental pollutants, such as heavy metals, antibiotics, pesticides, and so on. This study focuses on the environmental dynamics and the ecological functions of the eDNA and iDNA from the perspectives of environmental behavior, genetic information transmission, resistance to the environmental contaminants, and so on. By reviewing the status quo and the future vista of the e/iDNAs research, this article sheds light on exploring the ecological functioning of the e/iDNAs in the environmental microbiome.
OGG1 contributes to hepatocellular carcinoma by promoting cell cycle‐related protein expression and enhancing DNA oxidative damage repair in tumor cells
Authors: Zhang He , Jiang Peng‐jun , Lv Meng‐yuan , Zhao Yan‐hua , Cui Ju , Chen Jie 
Published: June 2022

AbstractBackgroundThis study aimed to analyze the expression of 8‐oxoguanine DNA glycosylase (OGG1) in patients with hepatocellular carcinoma (HCC) and its effect on prognosis by bioinformatics techniques and to determine its possible carcinogenic mechanism through data mining.MethodsThe difference in OGG1 expression between healthy people and HCC patients was searched and analyzed by TCGA and GEO databases, and the effect of OGG1 on prognosis was judged by survival analysis. Meanwhile, the possible molecular mechanism of OGG1 in the tumorigenesis and development of HCC was explored by GO analysis, KEGG analysis, immune infiltration analysis, protein–protein interaction network, promoter methylation analysis, and so forth. Quantitative polymerase chain reaction (qPCR) was used to examine the gene expression in 36 pairs of HCC tissues and adjacent tissues.ResultsThe expression of OGG1 in HCC patients was higher than that in healthy people, and the overexpression of OGG1 might stimulate cell proliferation by increasing the activity of cell cycle‐related proteins.ConclusionThe alteration of OGG1 was significantly correlated with the tumorigenesis and development of HCC. OGG1 is expected to be a new biomarker for evaluating the prognosis of HCC and a new target for the treatment of HCC.
Mass spectrometry methods for analysis of extracellular matrix components in neurological diseases
Authors: Downs Margaret , Zaia Joseph , Sethi Manveen K. 
Published: June 2022

AbstractThe brain extracellular matrix (ECM) is a highly glycosylated environment and plays important roles in many processes including cell communication, growth factor binding, and scaffolding. The formation of structures such as perineuronal nets (PNNs) is critical in neuroprotection and neural plasticity, and the formation of molecular networks is dependent in part on glycans. The ECM is also implicated in the neuropathophysiology of disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), and Schizophrenia (SZ). As such, it is of interest to understand both the proteomic and glycomic makeup of healthy and diseased brain ECM. Further, there is a growing need for site‐specific glycoproteomic information. Over the past decade, sample preparation, mass spectrometry, and bioinformatic methods have been developed and refined to provide comprehensive information about the glycoproteome. Core ECM molecules including versican, hyaluronan and proteoglycan link proteins, and tenascin are dysregulated in AD, PD, and SZ. Glycomic changes such as differential sialylation, sulfation, and branching are also associated with neurodegeneration. A more thorough understanding of the ECM and its proteomic, glycomic, and glycoproteomic changes in brain diseases may provide pathways to new therapeutic options.
Neuroimaging Correlates of Cognitive Deficits in Wilson's Disease
Authors: Shribman Samuel , Burrows Maggie , Convery Rhian , Bocchetta Martina , Sudre Carole H. , Acosta‐Cabronero Julio , Thomas David L. , Gillett Godfrey T. , Tsochatzis Emmanuel A. , Bandmann Oliver , Rohrer Jonathan D. , Warner Thomas T. 
Published: June 2022

AbstractBackgroundCognitive impairment is common in neurological presentations of Wilson's disease (WD). Various domains can be affected, and subclinical deficits have been reported in patients with hepatic presentations. Associations with imaging abnormalities have not been systematically tested.ObjectiveThe aim was to determine the neuroanatomical basis for cognitive deficits in WD.MethodsWe performed a 16‐item neuropsychological test battery and magnetic resonance brain imaging in 40 patients with WD. The scores for each test were compared between patients with neurological and hepatic presentations and with normative data. Associations with Unified Wilson's Disease Rating Scale neurological examination subscores were examined. Quantitative, whole‐brain, multimodal imaging analyses were used to identify associations with neuroimaging abnormalities in chronically treated stable patients.ResultsAbstract reasoning, executive function, processing speed, calculation, and visuospatial function scores were lower in patients with neurological presentations than in those with hepatic presentations and correlated with neurological examination subscores. Deficits in abstract reasoning and phonemic fluency were associated with lower putamen volumes even after controlling for neurological severity. About half of patients with hepatic presentations had poor performance in memory for faces, cognitive flexibility, or associative learning relative to normative data. These deficits were associated with widespread cortical atrophy and/or white matter diffusion abnormalities.ConclusionsSubtle cognitive deficits in patients with seemingly hepatic presentations represent a distinct neurological phenotype associated with diffuse cortical and white matter pathology. This may precede the classical neurological phenotype characterized by movement disorders and executive dysfunction and be associated with basal ganglia damage. A binary phenotypic classification for WD may no longer be appropriate. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
An Operative Electrostatic Slipping Mechanism along Macrocycle Flexibility Accelerates Guest Sliding during pseudo‐Rotaxane Formation
Authors: Catalán Aldo C. , Loredo Axel A. , Cervantes Ruy , Tiburcio Jorge 
Published: June 2022

AbstractA pseudo‐rotaxane is a host−guest complex composed of a linear molecule encircled by a macrocyclic ring. These complexes can be assembled by sliding the host over the guest terminal groups. If there is a close match between the molecular volume of the flanking groups on the guest and the cavity size of the macrocycle, the slipping might occur slowly or even become completely hindered. We have previously shown that it is possible to overcome the restraints imposed by steric effects on the sliding process by integrating electrostatic attractive interactions during the slipping step. In this work, we extend our electrostatically assisted slipping approach (EASA) to a new host−guest system featuring a flexible macrocyclic ring and a series of asymmetric guests containing a cyclic tertiary ammonium group. Compelling evidence for pseudo‐rotaxane formation is presented, along with thermodynamic and kinetic data. Experimental results suggests that the higher conformational flexibility of 24‐crown‐8 significantly increases the sliding rate, compared with the more rigid dibenzo‐24‐crown‐8, without affecting complex stability. Furthermore, by combining the EASA and macrocycle flexibility, we were capable to slip a large eight‐membered cyclic group across the 24‐crown‐8 annulus, setting a new limit on the ring molecular size that can pass through a 24‐membered crown ether.
Effects of graphene nanoparticles with organic wood particles: A synergistic effect on the structural, physical, thermal, and mechanical behavior of hybrid composites
Authors: Saha Abir , Kumar Santosh 
Published: June 2022

AbstractDevelopment of sustainable and lighter‐weight materials with low or zero carbon footprint is the major research field in 21st century. The current research has been focused on the development of hybrid composite materials from organic wood particles and graphene nanoparticles (GNPs) along with epoxy resin as matrix material. A constant 5% weight percentage of wood particles has been maintained, while GNPs weight percentages have been varied from 0% to 1% by weight with an equal interval of 0.25. The effects of GNPs addition on wood particle reinforced epoxy composite have been examined by performing different structural, physical, mechanical, thermal, and dynamic mechanical testings. The addition of GNPs up to 0.75% resulted in the increment of 28% hardness, 42.04% tensile strength, 34.24% flexural strength, 22.47% impact strength, and 16.3% fracture toughness, and 129.61% conductivity compared with wood composites (GPC‐0.0). Similar observations have been observed for dynamic mechanical analysis where, the GPC‐0.75 composites recorded maximum storage modulus (2.54 GPa), viscous modulus (0.27 GPa), and glass transition temperature (97°C). Further increments of graphene percentage (GPC‐1.0) resulted in agglomeration between particles and revealed decrements properties. The structural analysis of wood particles and GNPs have been examined with X‐ray diffractometer, Fourier transforms infrared spectroscopy, and thermogravimetric analysis. The developed composites showed better interfacial bonds between matrix and reinforcements that reduce the void and moisture contents as well as improved the fracture behavior. Therefore, these filter‐hybrid composites may be used for energy harvesting, solar cells, electronic gadgets, sensor, and heating equipment.
A map of the spatial distribution and tumour‐associated macrophage states in glioblastoma and grade 4 IDH‐mutant astrocytoma
Authors: Yin Wen , Ping Yi‐Fang , Li Fei , Lv Sheng‐Qing , Zhang Xiao‐Ning , Li Xue‐Gang , Guo Ying , Liu Qing , Li Tian‐Ran , Yang Liu‐Qing , Yang Kai‐Di , Liu Yu‐Qi , Luo Chun‐Hua , Luo Tao , Wang Wen‐Ying , Mao Min , Luo Min , He Zhi‐Cheng , Cao Mian‐Fu , Chen Cong , Miao Jing‐Ya , Zeng Hui , Wang Chao , Zhou Lei , Yang Ying , Yang Xi , Wang Qiang‐Hu , Feng Hua , Shi Yu , Bian Xiu‐Wu 
Published: June 2022

AbstractTumour‐associated macrophages (TAMs) abundantly infiltrate high‐grade gliomas and orchestrate immune response, but their diversity in isocitrate dehydrogenase (IDH)‐differential grade 4 gliomas remains largely unknown. This study aimed to dissect the transcriptional states, spatial distribution, and clinicopathological significance of distinct monocyte‐derived TAM (Mo‐TAM) and microglia‐derived TAM (Mg‐TAM) clusters across glioblastoma‐IDH‐wild type and astrocytoma‐IDH‐mutant‐grade 4 (Astro‐IDH‐mut‐G4). Single‐cell RNA sequencing was performed on four cases of human glioblastoma and three cases of Astro‐IDH‐mut‐G4. Cell clustering, single‐cell regulatory network inference, and gene set enrichment analysis were performed to characterize the functional states of myeloid clusters. The spatial distribution of TAM subsets was determined in human glioma tissues using multiplex immunostaining. The prognostic value of different TAM‐cluster specific gene sets was evaluated in the TCGA glioma cohort. Profiling and unbiased clustering of 24,227 myeloid cells from glioblastoma and Astro‐IDH‐mut‐G4 identified nine myeloid cell clusters including monocytes, six Mo/Mg‐TAM subsets, dendritic cells, and proliferative myeloid clusters. Different Mo/Mg‐TAM clusters manifest functional and transcriptional diversity controlled by specific regulons. Multiplex immunostaining of subset‐specific markers identified spatial enrichment of distinct TAM clusters at peri‐vascular/necrotic areas in tumour parenchyma or at the tumour–brain interface. Glioblastoma harboured a substantially higher number of monocytes and Mo‐TAM‐inflammatory clusters, whereas Astro‐IDH‐mut‐G4 had a higher proportion of TAM subsets mediating antigen presentation. Glioblastomas with a higher proportion of monocytes exhibited a mesenchymal signature, increased angiogenesis, and worse patient outcome. Our findings provide insight into myeloid cell diversity and its clinical relevance in IDH‐differential grade 4 gliomas, and may serve as a resource for immunotherapy development. © 2022 The Pathological Society of Great Britain and Ireland.
Effect of aluminosilicate nanoclay on polyester composites' static and dynamic mechanical properties
Authors: Seetharaman Arulmurugan , Narayanan Venkateshwaran 
Published: June 2022

AbstractIn this research, the effect of the addition of aluminosilicate (bentonite) nanoclay powder on the mechanical and dynamic mechanical behavior of polyester composites was investigated. Nanoclay laminates were fabricated in four different combinations, and the effect of nanofiller addition on the mechanical behaviors has been tested under ASTM Standards. The nanoclay and polyester resin were mixed using the ultrasonication process. Due to the enhanced interface between nanoclay and polyester, the flexural, tensile, and impact characteristics of laminates were boosted by clay addition. The loss modulus, storage modulus, and tan δ of the specimen were studied as a function of temperature and frequency of oscillation using a dynamic mechanical analyzer, and it was discovered that the addition of 5 wt% bentonite clay provided better strength and had the highest storage modulus than the other laminates. A morphology analysis was done on the fractured specimens through the scanning electron microscopy.
Screening for musculoskeletal system malformations and birth injuries in newborns: Results of a screening program in two hospitals in Shenzhen, China
Authors: Xiong Zhu , Zhao Zhenhui , Deng Hansheng , Qiu Xin , Li Weiqing , Chen Xiaodi , Tang Yu , Han Shuai , Zhao Jiaxin , Cai Ting , Liu Xian , Zeng Shuaidan , Tang Shengping 
Published: June 2022

ABSTRACTImportanceThere are a variety of musculoskeletal malformations and injuries that can occur in newborns. These can be a significant cause of perinatal death or a reason for miscarriage and can lead to long‐term functional issues if not managed appropriately. There is no systematic and well‐established screening program for neonatal musculoskeletal malformations and injuries in China now.ObjectiveTo report the incidence and types of congenital musculoskeletal malformations in two hospitals in Shenzhen City, to explore and discuss the details of the screening procedure and improve future prevention and treatment.MethodsFrom October 2013 to May 2014, 2564 one‐day‐old newborns were screened by a pediatric orthopedic physical examination, in combination with ultrasonography when required, and the incidence and variety of diseases were recorded statistically.ResultsAmong 2564 screened newborns, the following musculoskeletal conditions were identified: congenital muscular torticollis (CMT) (seven cases, 0.27%), hip subluxation (four cases, 0.16%), hip dysplasia (47 cases, 1.83%), congenital talipes equinovarus (CTEV) (two cases, 0.08%), congenital talipes calcaneovalgus (15 cases, 0.58%), polydactyly (nine cases, 0.35%), syndactyly (one case, 0.04%), and spinal hemivertebra (one case, 0.04%). Additionally, there were five (0.19%) neonates with birth injuries.InterpretationIt is feasible to carry out neonatal screening and identification of musculoskeletal malformations and birth injuries in China. This is helpful as timely detection and early intervention for many of these conditions can avoid permanent functional impairment in these children.
Immigrants, deviants, and drug users: A rhetorical analysis of President Trump's fear‐driven tweets during the 2019 government shutdown
Authors: Bustinza Monica A. , Witkowski Kaila 
Published: June 2022

AbstractSocial media platforms are widely used by numerous political officials to quickly disseminate information and/or obtain influence. Yet, little emphasis has been placed on analyzinghowthe dissemination of contentious messages is propagated using these e‐platforms. The purpose of this study is to examine President Donald J. Trump's political rhetoric about immigration policies during the 2018–2019 government shutdown. In doing so, we qualitatively coded 1411 of Trump's tweets from October 1, 2018, to February 5, 2019, for the presence of fear‐consistent appraisals and applied quantitative content analysis techniques to analyze the coded tweets. This study highlights the President's use of fear‐inducing rhetoric to garner political support and negatively target vulnerable groups by questioning America's ability to cope with immigration. Moreover, the results highlight the responsibility of policymakers in discussing vulnerable populations.