bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Information in Later-Life Sexuality: An Invitation for Further Exploration
Authors: Dalmer Nicole K , Marshall Barbara L 
Published: April 2022

AbstractDespite the key role of information in realizing, questioning, or respecting one’s sexual health, individuals’ engagement with information about sex and sexuality remains understudied, particularly in older adult populations. Beginning with current understandings of later-life sexuality to contextualize how older adults may need, use, and manage information about their sexual lives and practices, this forum article follows with what is currently known about older adults’ sexuality-related information needs and practices. We conclude with an invitation for collaboration between gerontologists and Library and Information Science scholars and professionals as a means to step outside the medicalization of older adults’ sexuality and bolster our understandings of how information and later-life sexuality are mututally shaping.
My AI Friend: How Users of a Social Chatbot Understand Their Human–AI Friendship
Authors: Brandtzaeg Petter Bae , Skjuve Marita , Følstad Asbjørn 
Published: April 2022

AbstractUse of conversational artificial intelligence (AI), such as humanlike social chatbots, is increasing. While a growing number of people is expected to engage in intimate relationships with social chatbots, theories and knowledge of human–AI friendship remain limited. As friendships with AI may alter our understanding of friendship itself, this study aims to explore the meaning of human–AI friendship through a developed conceptual framework. We conducted 19 in-depth interviews with people who have a human–AI friendship with the social chatbot Replika to uncover how they understand and perceive this friendship and how it compares to human friendship. Our results indicate that while human–AI friendship may be understood in similar ways to human–human friendship, the artificial nature of the chatbot also alters the notion of friendship in multiple ways, such as allowing for a more personalized friendship tailored to the user’s needs.
Parental fecundability and neurodevelopmental delays and difficulties in offspring
Authors: Magnus Maria C , Havdahl Alexandra , Wilcox Allen J , Goisis Alice 
Published: April 2022

Abstract

Background
Impaired neurodevelopment is reported among children conceived by assisted reproductive technologies (ART). However, this might be explained by conditions underlying parental subfecundity, rather than the ART procedure.

Methods
We examined associations of parental time-to-pregnancy (TTP) and conception by ART with neurodevelopmental traits up to 8 years of age, including motor and language skills, social delays and difficulties, and inattention-hyperactivity, among 92 142 singletons participating in the Norwegian Mother, Father and Child Cohort Study (MoBa). Mothers reported TTP and neurodevelopmental traits through questionnaires. Mean differences in standardized neurodevelopmental traits were estimated using linear regression, adjusting for maternal age, parity, educational level, body mass index and smoking, and paternal age.

Results
A longer TTP was associated with decreased language skills and motor skills at 6, 18 and 36 months (P-values for trend ≤0.01), prosocial skills delay at 36 months (P-values for trend ≤0.001) and increased scores for inattention-hyperactivity traits at all ages up to 8 years (P-values for trend from 0.06 to 0.01). Effect sizes were small, ranging between 0.03 and 0.05 difference in the standardized neurodevelopmental scores. Estimates for ART were imprecise, but there were no differences between children conceived by ART and naturally conceived children of subfecund parents (TTP ≥12 months).

Conclusions
Longer parental TTP is modestly but robustly associated with offspring neurodevelopmental delays and difficulties, with no added impact of ART. Future studies should investigate the underlying causes of—or aspects related to—parental subfecundity which might explain the association with offspring neurodevelopmental delays and difficulties.
On the Homotopy Type of Intersections of Two Real Bruhat Cells
Authors: Alves Emília , Saldanha Nicolau C 
Published: April 2022

Abstract
Real Bruhat cells give an important and well-studied stratification of such spaces as $\operatorname {GL}_{n+1}$, $\operatorname {Flag}_{n+1} = \operatorname {SL}_{n+1}/B$, $\operatorname {SO}_{n+1}$, and $\operatorname {Spin}_{n+1}$. We study the intersections of a top dimensional cell with another cell (for another basis). Such an intersection is naturally identified with a subset of the lower nilpotent group $\operatorname {Lo}_{n+1}^{1}$. We are particularly interested in the homotopy type of such intersections. In this paper, we define a stratification of such intersections. As a consequence, we obtain a finite CW complex that is homotopically equivalent to the intersection. We compute the homotopy type for several examples. It turns out that for $n \le 4$ all connected components of such subsets of $\operatorname {Lo}_{n+1}^1$ are contractible: we prove this by explicitly constructing the corresponding CW complexes. Conversely, for $n \ge 5$ and the top permutation, there is always a connected component with even Euler characteristic and therefore not contractible. This follows from formulas for the number of cells per dimension of the corresponding CW complex. For instance, for the top permutation $S_6$, there exists a connected component with Euler characteristic equal to $2$. We also give an example of a permutation in $S_6$ for which there exists a connected component that is homotopically equivalent to the circle ${{\mathbb {S}}}^1$.
Hamsters Protected from SARS-CoV-2 Delta Variant Challenge after Two Doses of Adjuvanted SARS-CoV-2 Recombinant Spike Protein (S-2P) and One Dose of Beta S-2P
Authors: Kuo Tsun-Yung , Lien Chia En , Lin Yi-Jiun , Lin Meei-Yun , Wu Chung-Chin , Tang Wei-Hsuan , Campbell John D , Traquina Paula , Chuang Ya-Shan , Liu Luke Tzu-Chi , Cheng Jinyi , Chen Charles 
Published: April 2022

Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern negatively impact the effectiveness of vaccines. In this study, we challenge hamsters with the delta variant after 2- or 3-dose inoculations with SARS-CoV-2 vaccines constructed from stabilized prefusion spike proteins (S-2P) of Wuhan (W) and beta (B) variants. Compared to 3 doses of W S-2P, 2 doses of W S-2P followed by a third dose of B S-2P induced the highest neutralizing antibody titer against live SARS-CoV-2 virus and enhanced neutralization of omicron variant pseudovirus. Reduced lung live virus titer and pathology suggested that all vaccination regimens protect hamsters from SARS-CoV-2 delta variant challenge.
Serial Homology and Segment Identity in the Arthropod Head
Authors: Lev Oren , Edgecombe Gregory D , Chipman Ariel D 
Published: April 2022

SynopsisThe anterior-most unit of the crown-group arthropod body plan includes three segments, the pre-gnathal segments, that contain three neuromeres that together comprise the brain. Recent work on the development of this anterior region has shown that its three units exhibit many developmental differences to the more posterior segments, to the extent that they should not be considered serial homologs. Building on this revised understanding of the development of the pre-gnathal segments, we suggest a novel scenario for arthropod head evolution. We posit an expansion of an ancestral single-segmented head at the transition from Radiodonta to Deuteropoda in the arthropod stem group. The expanded head subdivided into three segmental units, each maintaining some of the structures of the ancestral head. This scenario is consistent with what we know of head evolution from the fossil record and helps reconcile some of the debates about early arthropod evolution.
Effectiveness and safety of colistin among older adults: a systematic review and meta-analysis
Authors: Margalit Ili , Prendki Virginie , Tishler Ori , Falcone Marco , Tiseo Giusy , Leibovici-Weissman Yaara , Paul Mical , Yahav Dafna ,   ESCMID Study Group for Infections in the Elderly (ESGIE)
Published: April 2022

Abstract

Objectives
Limited data are available to guide colistin use in older adults (&gt;65 years old). We aimed to assess the effectiveness and safety of colistin in this population.

Methods
Systematic review and meta-analysis of original data from randomized control trials, cohort studies and case–control studies assessing colistin regimens with various comparisons for any infection. Original data were obtained from corresponding authors of original studies. The primary outcome was all-cause 1 month mortality; secondary outcomes included clinical and microbiological outcomes and adverse events, including acute kidney injury. Two independent reviewers screened citations, extracted data and assessed risk of bias. ORs with 95% CIs were pooled.

Results
We included 38 publications (41 comparisons) reporting 2857 elderly individuals: 29 studies compared a colistin-based regimen versus another regimen (comparison 1) and 10 compared colistin monotherapy versus colistin combination (comparison 2). No significant difference in 1 month mortality was demonstrated between colistin and comparator (comparison 1, OR 1.13, 95% CI 0.80–1.60; comparison 2, OR 0.99, 95% CI 0.78–1.27). Clinical failure was significantly more likely with colistin-based therapy versus comparator (OR 1.52, 95% CI 1.13–2.06). Acute kidney injury was also significantly more common with colistin-based combinations versus other drugs (OR 3.81, 95% CI 2.14–6.77).

Conclusions
For older adults, colistin-based therapy resulted in no mortality difference, compared with other regimens, for any infection. Clinical failure and acute kidney injury were significantly more common with colistin-based regimens. Close renal function monitoring is needed while using colistin in older adults.
Consumer workarounds during the COVID-19 pandemic: analysis and technology implications using the SAMR framework
Authors: Yin Kathleen , Coiera Enrico , Jung Joshua , Rohilla Urvashi , Lau Annie Y S 
Published: April 2022

Abstract

Objective
To understand the nature of health consumer self-management workarounds during the COVID-19 pandemic; to classify these workarounds using the Substitution, Augmentation, Modification, and Redefinition (SAMR) framework; and to see how digital tools had assisted these workarounds.

Materials and Methods
We assessed 15 self-managing elderly patients with Type 2 diabetes, multiple chronic comorbidities, and low digital literacy. Interviews were conducted during COVID-19 lockdowns in May–June 2020 and participants were asked about how their self-management had differed from before. Each instance of change in self-management were identified as consumer workarounds and were classified using the SAMR framework to assess the extent of change. We also identified instances where digital technology assisted with workarounds.

Results
Consumer workarounds in all SAMR levels were observed. Substitution, describing change in work quality or how basic information was communicated, was easy to make and involved digital tools that replaced face-to-face communications, such as the telephone. Augmentation, describing changes in task mechanisms that enhanced functional value, did not include any digital tools. Modification, which significantly altered task content and context, involved more complicated changes such as making video calls. Redefinition workarounds created tasks not previously required, such as using Google Home to remotely babysit grandchildren, had transformed daily routines.

Discussion and Conclusion
Health consumer workarounds need further investigation as health consumers also use workarounds to bypass barriers during self-management. The SAMR framework had classified the health consumer workarounds during COVID, but the framework needs further refinement to include more aspects of workarounds.
Thermal energy performance due to convection process of nanofluid in a porous medium due to split lid motion in a right triangular enclosure
Authors: Ullah M Zaka , Hussain S T , Haq Rizwan Ul , Alzahrani A Khamis , Mallawi Fouad 
Published: April 2022

Abstract
In the current phenomena, a study is carried out for the convection process of nanofluid within the porous media enclosed in a triangular permeable cavity. The heat generation effect within the nanofluid is developed when the two heat sources are applied through the split lids. To analyse the behaviour of nanofluids and steam lines, we have considered an elliptic (cold, adiabatic, and heated)-shaped obstacle that is placed inside the cavity. Mathematical modelling is carried out through continuity, momentum equation, and energy equations in the form of a system of non-linear partial differential equations. These equations are produced after incorporating the relations of viscosity, density, shapes of nanoparticle, and thermal conductivity for nanofluids Constraints are adjusted according to the forced convection due to the upper moving wall of the cavity. Four different cases of the upper double lid-driven wall are considered. All the emerging parameters, namely Reynolds number $( {25 \le {\rm{Re}} \le 750} ),$ heat generation $( { - {{10}^4} \le Q \le 40} ),\ $ nanoparticle volume fraction $\ ( {0 \le \phi \le 0.2} )$, and Darcy number ${10^{ - 5}} \le Da \le {10^{ - 3}}$, are analysed through variation of velocities, temperature profile, isotherms, and streamlines. Various cases at the surface of the inner elliptical obstacle provide significant contributions in the variation of heat transfer rate and velocity profiles. Nanoparticles provide a considerable increase in the heat transfer rate. The Darcy number shows the substantial variation in the formation of the isothermal region. An increase in heat generation parameter Q provides an improvement in temperature distribution inside the cavity and it also caused the formation of a single isothermal region around the heated obstacle.
Synonymous Variants: Necessary Nuance in Our Understanding of Cancer Drivers and Treatment Outcomes
Authors: Kaissarian Nayiri M , Meyer Douglas , Kimchi-Sarfaty Chava 
Published: April 2022

AbstractOnce called “silent mutations” and assumed to have no effect on protein structure and function, synonymous variants are now recognized to be drivers for some cancers. There have been significant advances in our understanding of the numerous mechanisms by which synonymous single nucleotide variants (sSNVs) can affect protein structure and function by affecting pre-mRNA splicing, mRNA expression, stability, folding, micro-RNA binding, translation kinetics, and co-translational folding. This review highlights the need for considering sSNVs in cancer biology to gain a better understanding of the genetic determinants of human cancers and to improve their diagnosis and treatment. We surveyed the literature for reports of sSNVs in cancer and found numerous studies on the consequences of sSNVs on gene function with supporting in vitro evidence. We also found reports of sSNVs that have statistically significant associations with specific cancer types but for which in vitro studies are lacking to support the reported associations. Additionally, we found reports of germline and somatic sSNVs that were observed in numerous clinical studies and for which in silico analysis predicts possible effects on gene function. We provide a review of these investigations and discuss necessary future studies to elucidate the mechanisms by which sSNVs disrupt protein function and play a role in tumorigeneses, cancer progression, and treatment efficacy. As splicing dysregulation is one of the most well-recognized mechanisms by which sSNVs impact protein function, we also include our own in silico analysis for predicting which sSNVs may disrupt pre-mRNA splicing.
Impacted common bile duct stone managed by hepaticoduodenostomy
Authors: Weledji Elroy Patrick , Mbengawo Ndiformuche Zikirou , Zouna Frank 
Published: April 2022

Abstract
A bypass procedure such as a hepaticoduodenostomy may be an alternative to the traditional choledochoduodenostomy in the management of the retained, impacted distal common bile duct stone especially in the presence of sepsis. In low-resource settings with lack of fluoroscopy, fibreoptic instruments (choledoscope) or radiologically guided wire baskets or balloons for stone retrieval, there are operative hazards in blindly exploring the common bile duct. We present herein a hepaticoduodenostomy performed for a retained, impacted distal common bile duct stone in a low-resource setting with a good outcome. This impacted stone had complicated an open cholecystectomy for acute cholecystitis by causing the dehiscence of the cystic duct stump as a result of distal biliary obstruction.
A Deployed Soldier Presenting With Dyspnea and Orthopnea Due to a Morgagni Hernia
Authors: McMahon Michael , Kniery Kevin , Wingard Daniel , Destree Craig , Brown Colin , Nessler Thomas G 
Published: April 2022

ABSTRACT
Shortness of breath is an important complaint in the austere setting with a broad differential diagnosis. The difficulty of deployed patient movement and lack of diagnostic testing at treatment sites complicates its evaluation. This case highlights a young Soldier presenting with shortness of breath caused by a Morgagni hernia. A 25-year-old deployed male presented with a 1-month history of dyspnea with exertion and right-sided chest tightness. After initial diagnoses of bronchitis, later chest radiographs demonstrated a linear opacity in the right middle lobe (RML). The patient was transferred to a higher level of care where a chest computer tomography scan was consistent with Morgagni hernia. Morgagni hernias can present with a wide variety of clinical complaints, including gastrointestinal symptoms, dyspnea, and chest pain. A lack of familiarity among providers who care for adults and the nonspecific nature of the symptoms frequently cause a diagnostic delay in diagnosis. CXR is helpful in this diagnosis, although this case demonstrates that this hernia may appear similar to RML atelectasis or pneumonia.6 Computed tomography remains the modality of choice to confirm the diagnosis, as well as provide anatomical details and rule out complications. While most experts agree that Morgagni hernias should be surgically repaired, the optimal surgical technique remains uncertain.3 Despite its rarity, Morgagni hernia is important to consider in a broad range of clinical presentations. Its nonspecific symptoms, combined with radiographs that can mimic other disease entities, can lead to a delay in diagnosis, mistreatment, prolonged patient suffering, and complications.
Circular polarimetry of suspect wind-accreting magnetic pre-polars
Authors: Hakala Pasi , Parsons Steven G , Marsh Thomas R , Gänsicke Boris T , Ramsay Gavin , Schwope Axel , Hermes J J 
Published: April 2022

ABSTRACT
We present results from a circular polarimetric survey of candidate detached magnetic white dwarf – M dwarf binaries obtained using the Nordic Optical Telescope, La Palma. We obtained phase resolved spectropolarimetry and imaging polarimetry of seven systems, five of which show clearly variable circular polarisation. The data indicate that these targets have white dwarfs with magnetic field strengths &gt;80 MG. Our study reveals that cyclotron emission can dominate the optical luminosity at wavelengths corresponding to the cyclotron emission harmonics, even in systems where the white dwarfs are only wind-accreting. This implies that a very significant fraction of the stellar wind of the companion star is captured by the magnetic white dwarf reducing the magnetic braking in pre-cataclysmic variables (CVs). Furthermore, the polarimetric confirmation of several detached, wind-accreting magnetic systems provides observational constraints on the models of magnetic CV evolution and white dwarf magnetic field generation. We also find that the white dwarf magnetic field configuration in at least two of these systems appears to be very complex.
Pharmacokinetics, pharmacodynamics, and safety of single-dose subcutaneous sarilumab with or without methotrexate in Japanese patients with rheumatoid arthritis: Two single-dose studies
Authors: Ishii Tomonori , Sato Yukio , Munakata Yasuhiko , Kajiwara Miyuki , Takahashi Yoshinori , van Hoogstraten Hubert , Xu Christine , Kato Naoto , Takahashi Toshiya 
Published: April 2022

ABSTRACTObjectivesTo assess the safety and pharmacokinetics (PK) of single-dose subcutaneous (SC) sarilumab or tocilizumab SC ± methotrexate (MTX) and to assess the pharmacodynamics (PD) of sarilumab SC or tocilizumab SC monotherapy in Japanese rheumatoid arthritis (RA) patients.MethodsTDU13402 was a randomized, double-blind, placebo-controlled, single-ascending dose Phase 1 study (NCT01850680). Twenty-four patients (6 per treatment group) received sarilumab 50, 100, or 200 mg plus MTX or placebo (2 per cohort) on Day (D) 1; PK and safety were assessed through D57. PDY14191 was a randomized, open-label, single-dose study (NCT02404558). Thirty patients (15 per arm) received sarilumab 150 mg or tocilizumab 162 mg on D1; PK, PD, and safety were assessed through D43.ResultsTDU13402: mean serum sarilumab exposure increased in a greater than dose proportional manner from 50 to 200 mg dose with no clinically meaningful increase in treatment-emergent adverse events (TEAEs). PDY14191: PK profiles of single-dose sarilumab 150 mg or tocilizumab 162 mg were similar; some numerical differences in PD profiles and TEAEs were observed. Neutrophil count decrease/neutropenia was the most frequently reported TEAE with sarilumab treatment in both studies.ConclusionsPK, PD, and safety profiles of single-dose sarilumab SC with/without MTX were consistent with results anticipated in Japanese patients with RA.
Dynamic and facilitated binding of topoisomerase accelerates topological relaxation
Authors: Michieletto Davide , Fosado Yair A G , Melas Elias , Baiesi Marco , Tubiana Luca , Orlandini Enzo 
Published: April 2022

AbstractHow type 2 Topoisomerase (TopoII) proteins relax and simplify the topology of DNA molecules is one of the most intriguing open questions in genome and DNA biophysics. Most of the existing models neglect the dynamics of TopoII which is expected of proteins searching their targets via facilitated diffusion. Here, we show that dynamic binding of TopoII speeds up the topological relaxation of knotted substrates by enhancing the search of the knotted arc. Intriguingly, this in turn implies that the timescale of topological relaxation is virtually independent of the substrate length. We then discover that considering binding biases due to facilitated diffusion on looped substrates steers the sampling of the topological space closer to the boundaries between different topoisomers yielding an optimally fast topological relaxation. We discuss our findings in the context of topological simplification in vitro and in vivo.