bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic Status of the Tourism Sector during the COVID 19 Pandemic at Lake Toba Parapat
Authors: Raisha Ghadati Raudina  , Anthoni Veery Mardianta  
Published: October 2022

Parapat is the main gateway to Samosir Island and is often referred to as Parapat Tourism City. The presence of Lake Toba with its natural beauty makes the surrounding area a priority object and tourist attraction (ODTW) in North Sumatra. Currently, the Lake Toba area is designated as the National Tourist Destination (DPU) in North Sumatra. At the beginning of 2020, the world was shaken by the presence of the Covid-19 virus outbreak. The Indonesian government has also acted to contain the spread of Covid-19 by implementing the policy "Enforcement of Community Activities Restrictions Enforcement (PPKM)". The existence of these social restrictions has led to the stagnation of the tourism industry. The state of Indonesia's tourism economy, especially Parapat, remains volatile due to the Covid-19 pandemic. The purpose of this study is to investigate the economic situation of the tourist destinations of Parapat in the Covid-19 pandemic. This study uses a qualitative study with a descriptive approach. The data collection techniques used in this study include observational studies and literature studies. Looking at the economy of the tourism sector based on the WTO's Tourism Baseline Index for tourism destinations, there are three parameters: business investment in tourism, income from the tourism sector, and public spending. According to the survey, in 2020, the Covid-19 pandemic and the government's implementation of the Community Activities Restrictions Enforcement (PPKM) caused the decline of various economic sectors in the tourism industry
Fish Landing Base in Pantai Cermin with Ecological Architecture Approach
Authors: Daffa Farras Arfy  , Pane Imam Faisal 
Published: October 2022

Indonesia is a maritime country that has a sea area of ​​5.8 million km², with enormous potential for marine products. The fisheries sector is one of the things that supports the third largest Indonesian economy with a GDP (Gross Domestic Product) of Rp 1.900 billion. There are many fishery ports in Indonesia commonly referred to as Fish Landing Base. In North Sumatra itself, there are 23 Fish Landing Base, and one of the areas that include it in the RTRW (Regional Spatial Plan) is Serdang Bedagai Regency, especially in Cermin Beach sub-district. However, the fact that the fisheries sector is not the main attraction of the Pantai Cermin area indicates no fishery center. This Fish Landing Base uses problem-solving to solve existing problems, starting from the formulation stage, location surveys, data collection, literature studies, and comparative studies. To respond these issues, ecological architecture becomes the answer to the problem of design conditions, such as responding according to local conditions both from society and nature. Fish Landing Base in Pantai Cermin expect to respond to users comfortably, creates interaction between users and the environment, and can also form a public space so that it can encourage economic generators based on sources of life in coastal areas, and so become one of the new tourist destinations to enjoy the marine products of Indonesia, especially in Serdang Bedagai, North Sumatera.
Damage Assessment Method of Reinforcement Concrete Building By Fuzzy Theory
Authors: Jon Hyon Hui  , Song Yong IL  , Kim JI Yon  
Published: October 2022

As reinforcement concrete building is composition material which reinforcement bar and concrete work together, effect factors concerned with its damage are countlessly much and interrelationship between them is also very complex and indefiniteness. Until now many researches about the damage assessment of a building has been performed but the problem accounting correctly damage of the reinforcement concrete building by connecting several of damage factors has not yet been solved. In research a method accounting damage of reinforcement concrete building in the fuzzy integral way in consideration of fuzzy property existing in the damage assessment system of it has been newly suggested.
A research on the stability of repair-welding for a great truss under the load
Authors: Myong Il Kim  , Ju Chol Kwak  
Published: October 2022

In this paper, we developed the direct repair welding method without eliminating the load when the repair welding of the great steel truss is going. According to the information about the process and data systematized, working for eliminate defect of welding joint and analyzing used FEM on the stability of the process and result of welding-repair were scientific more than the last time at the great structure. When do this we did not eliminate defect from the part of joint and so it’s not necessity to use any Jackie and turning back. The result of analysis and construction show that this method is very useful in the practice and by then the problem of stability solved clearly and perfectly and the time and efforts had consumed.
Relationships among COVID-19 Prevention Practices, Risk Perception and Individual Characteristics: A Temporal Analysis
Authors: Wang Lu , Yu Jie , Chen Dongmei , Yang Lixia 
Published: October 2022

<p>The effectiveness of public health measures in containing an infectious disease largely depends on how the general public is taking the prevention practices in daily lives. Previous studies have shown that different risk perceptions and sociodemographic characteristics may lead to vastly different prevention behaviors. This paper applies a temporal perspective in examining the changing patterns of prevention practices over time and their dynamic relationships with the perceived risk towards COVID-19 and its individual characteristics. Three key timelines (February, April, and June of 2020) were identified to represent the early, lockdown, and reopening stages of the first wave. Data were drawn from an online survey conducted in the Greater Toronto Area (GTA) of Canada (<em>n </em>= 470). Chi-square tests and logistic regression models revealed important temporal patterns in practicing different hygienic and mobility-related prevention measures and the respondents’ risk perceptions during the three timelines. The factors predicting the level of prevention practices vary across the three timelines, based on the specific type of prevention, and within the changing public health contexts. This study contributes to the literature on COVID-19 by incorporating a temporal perspective in conceptualizing prevention predictors. It provides crucial insights for developing timely public health strategies to improve infectious disease prevention at different stages and for individuals with varying backgrounds. </p>
Cognitive Control in Young and Older Adults: Does Mood Matter?
Authors: Truong Linda , Kandasamy Kesaan , Yang Lixia 
Published: October 2022

<p>The dual mechanisms of control framework (DMC) proposes two modes of cognitive control: proactive and reactive control. In anticipation of an interference event, young adults primarily use a more proactive control mode, whereas older adults tend to use a more reactive one during the event, due to age-related deficits in working memory. The current study aimed to examine the effects of mood induction on cognitive control mode in older (ages 65+) compared to young adults (ages 18–30) with a standard letter-cue (Experiment 1) and a modified face-cue AX-CPT (Experiment 2). Mood induction into negative and/or positive mood versus neutral mood was conducted prior to the cognitive control task. Experiment 1 replicated the typical pattern of proactive control use in young adults and reactive control use in older adults. In Experiment 2, older adults showed comparable proactive control to young adults in their response time (RT). Mood induction showed little effect on cognitive control across the two experiments. These results did not reveal consistent effects of mood (negative or positive) on cognitive control mode in young and older adults, but discovered (or demonstrated) that older adults can engage proactive control when dichotomous face cues (female or male) are used in AX-CPT. </p>
Stress-induced pulmonary hypertension: definition and diagnosis
Authors: Naiden T. V. , Bartosh-Zelenaya S. Yu. , Fedoretz V. N. 
Published: October 2022

The first hemodynamic definition of pulmonary hypertension (PH) was given at the World Symposium on PH (WSPH, 1973) in Geneva as an increasebin resting mean pulmonary artery pressure (mPAP) >25 mm Hg by heart chamber catheterization. Since 2004, in the definition of PH, in addition to an increase in resting mPAP, an 'exercise' criterion has also been included: mPAP at the peak of exercise >30 mm Hg. However, at the 4th WSPH Symposium in 2008, due to uncertainty of the relationship between age-related changes in cardiac output (CO) and pulmonary vascular physiology, in particular pulmonary vascular resistance (PVR) under exercise, this criterion was excluded.Resting PH manifests only at the absence of ≥50 % of pulmonary microcirculation, so for the earliest diagnosis of the disease, it’s necessary to use factors that provoke an increase in CO and PVR. Moreover, in clinical practice, manifestations of PH are not uncommon on exercise. In the absence of consensus the definition of stress- induced PH is defined in individuals with normal mPAP (< 25 mm Hg) at rest and elevated mPAP (>30 mm Hg) and PVR> 3 WU at the peak of exercise.
Peripheral nerve ultrasound in ALS patients
Authors: Druzhinina E. S. , Druzhinin D. S. 
Published: October 2022

Introduction. Peripheral nerve ultrasound helps in the differential diagnosis of amyotrophic lateral sclerosis (ALS) and treatable diseases with a similar clinic. The cross–sectional area (CSA) values of the nerves of the hands and spinal nerves in ALS is normal or even reduced in comparison with control. The CSA of the nerves in a clinically similar condition – multifocal motor neuropathy (MMN) increases and has a characteristic ultrasound pattern of changes in the form of an increase in CSA in the proximal parts of the nerves of the hands and spinal nerves of the brachial plexuses.Materials and methods. Cervical root and peripheral nerve CSA on both sides was performed in 31 patients with ALS and 25 patients with MMN, using a 8–15 MHz linear array probe (ultrasound scanner «Sonoscape S20» (China). The control group included 92 healthy people without diseases of the nervous system, as well as conditions potentially causing damage to the peripheral nervous system.Results. The average values of the CSA of cervical roots and peripheral nerves in the upper limb in ALS patients were normal. However, there was an increase in the CSA of the median nerve at the shoulder level on the left by 23 %, the radial nerve on the right by 24 %, and the ulnar nerve on the left at the wrist level by 33 % in the ALS group compared with the control group. The CSA of nerves in MMN patients was significantly higher than in ALS and compared with the control group. In MMN nerve trunks increase was observed in the proximal parts of the nerves in the upper limb and cervical roots on both sides.Conclusions. Peripheral nerve ultrasound is a reliable tool for differential diagnosis ALS and ALS mimics. It can be widely used in routine clinical practice.
Comparative Studies of RSM, RSM–GA and ANFILS for Modeling and Optimization of Naphthalene Adsorption on Chitosan–CTAB–Sodium Bentonite Clay Matrix
Authors: Olaosebikan Abidoye Olafadehan  , Victor Ehigimetor Bello  
Published: October 2022

The aim of this article was to compare the predictive abilities of the optimization techniques of response surface methodology (RSM), the hybrid of RSM–genetic algorithm (RSM–GA) and adaptive neuro-fuzzy interference logic system (ANFILS) for design responses of % removal of naphthalene and adsorption capacity of the synthesized composite nanoparticles of chitosan–cetyltrimethylammonium bromide (CTAB)–sodium bentonite clay. The process variables considered were surfactant concentration, , activation time, , activation temperature, , and chitosan dosage, . The ANFILS models showed better modeling abilities of the adsorption data on the synthesized composite adsorbent than those of ANN for reason of lower % mean absolute deviation, lower % error value, higher coefficient of determination, , amongst others and lower error functions’ values than those obtained using ANN for both responses. When applied RSM, the hybrid of RSM–genetic algorithm (RSM–GA) and ANFILS 3–D surface pot optimization technique to determine the optimal conditions for both responses, ANFILS was adjudged the best. The ANFILS predicted optimal conditions were = 116.00 mg/L, = 2.06 h, = 81.2oC and = 5.20 g. Excellent agreements were achieved between the predicted responses of 99.055% removal of naphthalene and 248.6375 mg/g adsorption capacity and their corresponding experimental values of 99.020% and 248.86 mg/g with % errors of -0.0353 and 0.0894 respectively. Hence, in this study, ANFILS has been successfully used to model and optimize the conditions for the treatment of industrial wastewater containing polycyclic aromatic compounds, especially naphthalene and is hereby recommended for such and similar studies.
Regulatory network of ginsenoside biosynthesis under Ro stress in the hairy roots of Panax ginseng revealed by RNA sequencing
Authors: Meng Xiangru , Zhang Tao , Chen Changbao , Li Qiong , Liu Jingwan 
Published: October 2022

P. ginseng C.A. Meyer is a valuable Chinese herbal medicine that belongs to the Araliaceae family. Major obstacles to the continuous cropping of ginseng have severely restricted the sustainable development of the ginseng industry. The allelopathic effects of triterpenoid saponins play an important role in disorders related to continuous cropping; however, the mechanisms underlying the allelopathic autotoxicity of triterpenoid ginsenosides remain unknown. In this study, we performed mRNA and miRNA sequencing analyses to identify candidate genes and miRNAs that respond differentially to ginsenoside Ro stress in ginseng and their targets. The growth of the ginseng hairy roots was significantly inhibited under Ro stress (0.5 mg/L, Ro-0.5). The inhibition of root growth and injury to root-tip cells promoted the accumulation of the endogenous hormones indole-3-acetic acid and salicylic acid and inhibited the accumulation of abscisic acid and jasmonate acid. The accumulation of ginsenosides, except Rg3, was significantly inhibited under Ro-0.5 stress. An mRNA analysis of the Ro-0.5 and control groups showed that differentially expressed genes were mostly concentrated in the hormone signal transduction pathway. ARF7 and EFM were upregulated, whereas XTH23 and ZOX1 were downregulated. These genes represent important potential candidates for hormone-responsive continuous cropping diseases. In total, 74 differentially expressed miRNAs were identified based on the miRNA sequencing analysis, of which 22 were upregulated and 52 were downregulated. The target genes of ptc-miR156k_L + 1, mtr-miR156b-5p, gma-miR156a_R + 1, and mtr-miR156e all belonged to TRINITY_DN14567_c0_g4, which is a gene in the plant hormone signal transduction pathway. These four miRNAs were all negatively correlated with mRNA, indicating their likely involvement in the response of ginseng to continuous cropping disorders and the regulation of ginsenoside synthesis. Our findings provide useful insights for removing the barriers to continuous ginseng cropping and have important implications in the genetic engineering of plant stress responses.
Optimization of growth of Levilactobacillus brevis SP 48 and in vitro evaluation of the effect of viable cells and high molecular weight potential postbiotics on Helicobacter pylori
Authors: Cimini Donatella , D’ambrosio Sergio , Stellavato Antonietta , Fusco Alessandra , Corsaro Maria Michela , Dabous Azza , Casillo Angela , Donnarumma Giovanna , Giori Andrea Maria , Schiraldi Chiara 
Published: October 2022

Several Levilactobacillus brevis strains have the potential to be used as probiotics since they provide health benefits due to the interaction of live cells, and of their secreted products, with the host (tissues). Therefore, the development of simple fermentation processes that improve cell viability to reduce industrial production costs, and at the same time the characterization and biological evaluation of cell-free postbiotics that can further promote application, are of great interest. In the present study, small scale batch fermentations on semi defined media, deprived of animal derived raw materials, were used to optimize growth of L. brevis SP48, reaching 1.2 ± 0.4 × 1010 CFU/ml of viable cells after 16 h of growth. Displacement, competition, and inhibition assays compared the effect, on Helicobacter pylori, of L. brevis cells to that of its partially purified potentially postbiotic fraction rich in exopolysaccharides and proteins. The expression of pro and anti-inflammatory biochemical markers indicated that both samples activated antimicrobial defenses and innate immunity in a gastric model. Moreover, these compounds also acted as modulators of the inflammatory response in a gut in vitro model. These data demonstrate that the high molecular weight compounds secreted by L. brevis SP48 can contrast H. pylori and reduce inflammation related to intestinal bowel disease, potentially overcoming issues related to the preservation of probiotic viability.
Biomechanical and clinical evaluation of interlocking hip screw in Pauwels Ⅲ femoral neck fractures: A comparison with inverted triangle cannulated screws
Authors: Zhang Jian , Jiang Haozheng , Dai Wei , Hersi Salad Abdirahman , Chun tien chui wan Cheong John , Chu Zhenchen , Lou Zhiyuan , Zhang Deqiang , Liu Changjian , Tian Kang , Tang Xin 
Published: October 2022

Purpose: To compare biomechanical and clinical properties of the novel internal fixation Interlocking Hip Screw (IHS) and conventional inverted triangle cannulated screws (ITCS) for treatment of Pauwels Ⅲ femoral neck fractures.Methods: Twenty synthetic femurs were osteotomized to simulate 70° Pauwels Ⅲ femoral neck fractures and randomly divided into two groups: Group IHS and Group ITCS. Specimens were loaded in quasi-static ramped and cyclical compression testing in 25° adduction to analyze for axial stiffness, failure load, and interfragmentary displacement. 21 matched patients with Pauwels Ⅲ femoral neck fracture who received closed reduction and internal fixation from January 2020 to January 2021 in both Group IHS and Group ITCS. Demographic data, time to surgery, operating duration, intraoperative blood loss, number of fluoroscopies, length of hospital stay, fracture healing time, Harris Hip Score (HHS), the score of Visual Analogue Scale (VAS) and complications such as nonunion, avascular necrosis, and femoral neck shortening were compared.Results: All specimens in the two groups survived in the axial and cyclical compression test. The axial stiffness was significantly higher for Group IHS (277.80 ± 26.58 N/mm) versus Group ITCS (205.33 ± 10.46 N/mm), p &lt; 0.05. The maximum failure loading in Group IHS performed significantly higher than in Group ITCS (1,400.48 ± 71.60 N versus 996.76 ± 49.73 N, p &lt; 0.05). The interfragmentary displacement of the cyclic loading test for Groups IHS and Group ITCS was 1.15 ± 0.11 mm and 1.89 ± 0.14 mm, respectively, p &lt; 0.05. No significant difference was found in terms of demographic data, time to surgery, intraoperative blood loss, length of hospital stay and the occurrence of nonunion and avascular necrosis between groups. Shorter operating duration and fewer intraoperative fluoroscopic views were noticed using IHS compare to ITCS, p &lt; 0.05. The HHS was 72.14 ± 5.76 and 86.62 ± 5.01 in Group IHS, and was 67.29 ± 5.27 and 81.76 ± 5.13 in Group ITCS at 3-month and 6-month follow-up, respectively, p &lt; 0.05. The magnitude of femoral neck shortening was significantly lower in Group IHS compared to Group ITCS (4.80 ± 1.03 mm versus 5.56 ± 1.21 mm, p &lt; 0.05).Conclusion: Our study demonstrated that IHS provided better biomechanical and clinical performance due to its unique biological and biomechanical mechanisms, compared with ITCS. Thus, IHS is a feasible alternative to ITCS for the fixation of Pauwels Ⅲ femoral neck fractures.
Biomineralized hybrid nanodots for tumor therapy via NIR-II fluorescence and photothermal imaging
Authors: Niu Xuegang , Wei Penghui , Sun Jiangnan , Lin Yuanxiang , Chen Xiaoyong , Ding Chenyu , Zhu Yang , Kang Dezhi 
Published: October 2022

Chemodynamic therapy (CDT) is an emerging and promising therapeutic strategy that suppresses tumor growth by catalytically converting intracellular hydrogen peroxide (H2O2) into highly-reactive hydroxyl radicals (•OH). However, the inherent substrate of H2O2 is relatively insufficient to achieve desirable CDT efficacy. Therefore, searching for integrated therapeutic methods with synergistic therapeutic modality is especially vital to augment therapeutic outcomes. Herein, we reported nanodot- CuxMnySz @BSA@ICG (denoted as CMS@B@I) and bovine serum albumin (BSA)-based biomineralization CuxMnySz (CMS) loaded with photodynamic agent-indocyanine green (ICG). CMS@B@I converts endogenous hydrogen peroxide (H2O2) into highly active hydroxyl radical (•OH) via Fenton reaction, and effectively produces reactive oxygen species (ROS) after being exposed to 808 nm laser irradiation, attributable to the excellent photodynamic agent-ICG. This results in eliciting a ROS storm. Additionally, CMS@B@I exhibits a superior photothermal effect under NIR-II 1064 nm laser irradiation to enhance tumor CDT efficacy. The NIR-II fluorescence imaging agent of ICG and the excellent photothermal effect of CMS@B@I are highly beneficial to NIR-II fluorescence and infrared thermal imaging, respectively, resulting in tracing the fate of CMS@B@I. This study attempts to design a bimodal imaging-guided and photothermal-enhanced CDT nanoagent for augmenting tumor catalytic therapy.
An enzyme-activatable dual-readout probe for sensitive β-galactosidase sensing and Escherichia coli analysis
Authors: Huang Yifang , Feng Weiwei , Zhang Guo-Qiang , Qiu Yuling , Li Linlin , Pan Liqiu , Cao Nannan 
Published: October 2022

Rapid and accurate sensing of β-galactosidase (β-gal) activity is particularly critical for the early detection of many diseases and has become a topic of interest in recent years. However, most traditional probes for β-gal sensing often suffer from the disadvantages of narrow dynamic range, low reaction efficiency and are only employed with either colorimetric or fluorescence sensing. Furthermore, β-galactosidase sensing based assay for efficient detection and antibiotic resistance analysis of Escherichia coli (E.coli) is not available. Here, an enzyme-induced probe assay was reported for dual sensitive fluorescence and colorimetric measurement of β-gal activity, and was further employed for detection of Escherichia coli and their antibiotic resistance analysis. The DCM-βgal probe was virtually non-emissive in aqueous solution, while it could be activated by β-gal to produce bright emission. Under optimized conditions, DCM-βgal displayed high sensitivity, selectivity and rapid response to β-gal with a low detection limit of 1.5 × 10−3 U ml−1. Importantly, this assay was successfully applied to sensitive detection of E. coli cells with a fast detection process within 5 h and a low detection concentration of 1 × 103 CFU ml−1. Furthermore, the enzyme-activatable assay was also successfully applied for high throughput E. coli antibiotic resistance analysis. The DCM-βgal strategy is applied for the first time on the detection of E. coli cells and their antibiotic resistance analysis. It is provided with the advantages of high selectively, a simple operation, low cost and rapid detection. The detection platform can also be extended to analyze the level of β-gal in other types of cells or biological samples. Overall, the simple, effective and dual-readout assay holds promise for efficient sensing of β-gal activity and provides a potential tool for E. coli detection and their antibiotic resistance analysis.