bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feelings of loneliness, COVID-19-specific-health anxiety and depressive symptoms during the first COVID-19 wave in Swiss persons with multiple sclerosis
Authors: Hoepner Robert , Rodgers Stephanie , Stegmayer Katharina , Steinemann Nina , Haag Christina , Calabrese Pasquale , Manjaly Zina-Mary , Salmen Anke , Kesselring Jürg , Zecca Chiara , Gobbi Claudio , Puhan Milo A. , Walther Sebastian , von Wyl Viktor 
Published: October 2022

AbstractThe aim of our study was to investigate whether self-reported feeling of loneliness (FoL) and COVID-19-specific health anxiety were associated with the presence of depressive symptoms during the first coronavirus disease 2019 (COVID-19) wave. Questionnaires of 603 persons of the Swiss Multiple Sclerosis Registry (SMSR) were cross-sectionally analyzed using descriptive and multivariable regression methods. The survey response rate was 63.9%. Depressive symptoms were assessed by the Beck Depression Inventory-Fast Screen (BDI-FS). COVID-19-specific health anxiety and FoL were measured using two 5-item Likert scaled pertinent questions. High scoring FoL (2.52, 95% confidence interval (CI) (2.06—2.98)) and/or COVID-19 specific health anxiety (1.36, 95% CI (0.87–1.85)) were significantly associated with depressive symptoms. Further stratification analysis showed that the impact of FoL on depressive symptoms affected all age groups. However, it was more pronounced in younger PwMS, whereas an impact of COVID-19 specific health anxiety on depressive symptoms was particularly observed in middle-aged PwMS. FoL and COVID-19-specific health anxiety were age-dependently associated with depressive symptoms during the first COVID-19 wave in Switzerland. Our findings could guide physicians, health authorities, and self-help groups to better accompany PwMS in times of public health crises.
Estimation of best corrected visual acuity based on deep neural network
Authors: Lee Woongsup , Kim Jin Hyun , Lee Seongjin , Kim Kyonghoon , Kang Tae Seen , Han Yong Seop 
Published: October 2022

AbstractIn this study, we investigated a convolutional neural network (CNN)-based framework for the estimation of the best-corrected visual acuity (BCVA) from fundus images. First, we collected 53,318 fundus photographs from the Gyeongsang National University Changwon Hospital, where each fundus photograph is categorized into 11 levels by retrospective medical chart review. Then, we designed 4 BCVA estimation schemes using transfer learning with pre-trained ResNet-18 and EfficientNet-B0 models where both regression and classification-based prediction are taken into account. According to the results of the study, the predicted BCVA by CNN-based schemes is close to the actual value such that 94.37% of prediction accuracy can be achieved when 3 levels of difference can be tolerated during prediction. The mean squared error and$$R^2$$R2score were measured as 0.028 and 0.654, respectively. These results indicate that the BCVA can be predicted accurately for extreme cases, i.e., the level of BCVA is close to either 0.0 or 1.0. Moreover, using the Guided Grad-CAM, we confirmed that the macula and the blood vessel surrounding the macula are mainly utilized in the prediction of BCVA, which validates the rationality of the CNN-based BCVA estimation schemes since the same area is also exploited during the retrospective medical chart review. Finally, we applied the t-distributed stochastic neighbor embedding to examine the characteristics of CNN-based BCVA estimation schemes. The developed BCVA estimation schemes can be employed to obtain the objective measurement of BVCA as well as the medical screening of people with poor access to medical care through smartphone-based fundus imaging.
Vanillin-derived α,ω-diene monomer for thermosets preparation via thiol–ene click polymerization
Authors: Gao Zijun , You Yang , Chen Qin , North Michael , Xie Haibo 
Published: October 2022

Novel vanillin-derived α,ω-diene monomer was synthesized via Williamson and Tishchenko reaction, which was readily polymerized with thiols to obtain thiol-ene networks with tunable material properties and satisfactroy degradability under mild alkaline conditions.
Profiles of Children With Cortical Visual Impairment Who Use Augmentative and Alternative Communication: A Retrospective Examination
Authors: Blackstone Sarah , Luo Fei , Barker R. Michael , Sevcik Rose A. , Romski MaryAnn , Casella Vicki , Roman-Lantzy Christine 
Published: October 2022

Purpose:
Cortical visual impairment (CVI) is the most common cause of visual impairment in children today and can impact the outcomes of children who rely on augmentative and alternative communication (AAC). This study provides baseline data of 13 children with CVI who used AAC during their first year of participation in an integrated CVI program. One purpose was to describe similarities and differences in the student's demographic, functional vision, communication, and educational profiles. A second purpose was to examine differences in students described with different communicator profiles.

Method:
Archived student records were de-identified and reviewed using a systematic coding scheme. Two researchers independently reviewed and coded all student records. Reliability was established. Measures included CVI Range scores; supports for positioning, mobility, vision, and writing; AAC systems, including modes, access methods, and language representation; communicative competence; self-determination; literacy; and mathematics.

Results:
The study yielded a rich description of similarities and differences among students at baseline and led to careful consideration of differences among the participants with emergent communicator and context-dependent communicator profiles.

Conclusions:
Currently, limited evidence exists that informs practice regarding AAC assessment and intervention for children with CVI. This article describes a small sample of children with CVI who use AAC. Results underscore the need for educators and practitioners to ensure that vision functioning in students with CVI is evaluated carefully and regularly when conducting AAC assessment and intervention and formulating communication or education goals.

Supplemental Material:

https://doi.org/10.23641/asha.21357684
Update zur Mundgesundheit mit Zubereitungen aus
Preiselbeeren
Authors: Vlachojannis Julia , Chrubasik-Hausmann Sigrun 
Published: October 2022

ZusammenfassungDie verschiedenen Vaccinium-Arten unterscheiden sich im Spektrum ihrer
Inhaltsstoffe. Die skandinavische Preiselbeere (V. vitis-idaea)
enthält mehr Wirkstoff als die amerikanische Preiselbeere (V.
macrocarpon), früher auch Großfrüchtige
Moosbeere, Kraanbeere oder Kranichbeere, heute eher Cranberry genannt. Dennoch
besitzen auch Fraktionen aus der amerikanischen Cranberry eine starke Wirkung
gegen Karies und Periodontitis. Der Wirkungsmechanismus ist weitgehend
aufgeklärt. Die vorhandenen In-vitro-Daten erlauben derzeit noch
keine Abgrenzung zwischen den Vaccinium-Arten, da nur wenige
In-vitro-Studien mit V. vitis-idaea durchgeführt
wurden. Pilotstudien weisen darauf hin, dass der Wirkstoff beider
Vaccinium-Arten zur Förderung der Mundgesundheit genutzt
werden kann. Weitere Studien müssen jetzt die Wirkgrößen
definieren und den Unterschied zwischen den Vaccinium-Arten bei der
Mundgesundheit evaluieren.
Okuläre Nebenwirkungen bei adjuvanten Melanomtherapien
Authors: Boland Dorothea , Harth Wolfgang 
Published: October 2022

ZusammenfassungDas Maligne Melanom hat in den letzten Jahren eine deutliche Erweiterung des Behandlungsspektrums erfahren. Neue adjuvante und palliative Therapiekonzepte mittels BRAF-/MEK- und Checkpoint-Inhibitoren erzielen zudem eine deutliche Verbesserung der Behandlungsergebnisse. Durch den vermehrten Medikamenteneinsatz mit neuen Wirkmechanismen kommt es gleichzeitig zur Häufung von bis dato eher seltenen und untypischen Nebenwirkungen. Wir berichten über zwei Patienten mit okulären Nebenwirkungen bei adjuvanter Therapie bei Malignem Melanom.Eine biokuläre Glaskörperblutung nach adjuvanter Therapie mit BRAF-/MEK-Inhibitoren kann mittels mehrerer ophthalmologischer Operationen behandelt werden. Ein dadurch hocheingeschränkter Visus verbessert sich so auf einen regelrechten Visus.Unser zweiter Patient hat durch eine adjuvante Therapie mit einem Checkpoint-Inhibitor eine medikamenteninduzierte komplette Abduzenzparese entwickelt. Diese ist unter einer Prednisolonstoßtherapie komplett reversibel.Eine adäquate Risiko-Nutzen-Analyse für jeden Patienten ist besonders bei der adjuvanten Therapie notwendig.
Total Synthesis and Structural Revision of Cephalosporolide J
Authors: Ota Koichiro , Miyaoka Hiroaki , Kamaike Kazuo 
Published: October 2022

AbstractHerein, we report the first total synthesis of cephalosporolide J, which is a deep sea sediment derived polyketide harboring a unique bicyclo[3.3.0]furanolactone moiety. The adopted synthetic strategy consisted of the alkynylation of γ-lactone with lithium alkynyltrifluoroborate followed by a spiroketalization triggered by hydrogenation of the triple bond. Through this synthesis, the correct structure of cephalosporolide J is shown to be that of the 9-epi stereoisomer of the structure originally proposed.
Photocatalytic activity of MoS2 with water monolayers: Global optimization
Authors: Zhang Yachao 
Published: October 2022

Atomically thin MoS2 has emerged to be promising for photocatalytic water splitting benefiting from its suitable geometrical and electronic structure for light harvesting. A better understanding of how water molecules affect the band edge levels of MoS2 is critical for promoting the interfacial reactivity. Here, we determine the structures of water monolayers on MoS2 using global optimizations achieved by molecular dynamics in combination with local minimization. It is shown that cyclic water clusters are formed on a surface through a hydrogen-bonding network. The absolute band edge positions are explored taking into account the derivative discontinuity of the exchange–correlation functional. Shifts in band edges are observed with the increase in H2O coverage, while bandgaps tend to be slightly decreased. In particular, the band alignment relative to water redox potentials has been investigated in detail. We find that the dimer configuration is likely to suppress the hydrogen evolution reaction (HER), while the polygon clusters lift the conduction band by 0.2–0.7 eV, and thus, they would enhance HER. This effect is explained in terms of the linear dependence of the band edge offset on an interface electric dipole arising from water assemblies.
Molecular-based analysis of nanoparticle solvation: Classical density functional approach
Authors: Chuev Gennady , Dinpajooh Mohammadhasan , Valiev Marat 
Published: October 2022

Proper statistical mechanics understanding of nanoparticle solvation processes requires an accurate description of the molecular structure of the solvent. Achieving this goal with standard molecular dynamics (MD) simulation methods is challenging due to large length scales. An alternative approach to this problem can be formulated using classical density functional theory (cDFT), where a full configurational description of the positions of all the atoms is replaced by collective atomic site densities in the molecule. Using an example of the negatively charged silica-like system in an aqueous polar environment represented by a two-site water model, we demonstrate that cDFT can reproduce MD data at a fraction of the computational cost. An important implication of this result is the ability to understand how the solvent molecular features may affect the system’s properties at the macroscopic scale. A concrete example highlighted in this work is the analysis of nanoparticle interactions with sizes of up to 100 nm in diameter.
Ornithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription
Authors: Peng Vincent , Cao Siyan , Trsan Tihana , Bando Jennifer K. , Avila-Pacheco Julian , Cleveland John L. , Clish Clary , Xavier Ramnik J. , Colonna Marco 
Published: October 2022

Group 3 innate lymphoid cells (ILC3s) are RORγT
+
lymphocytes that are predominately enriched in mucosal tissues and produce IL-22 and IL-17A. They are the innate counterparts of Th17 cells. While Th17 lymphocytes utilize unique metabolic pathways in their differentiation program, it is unknown whether ILC3s make similar metabolic adaptations. We employed single-cell RNA sequencing and metabolomic profiling of intestinal ILC subsets to identify an enrichment of polyamine biosynthesis in ILC3s, converging on the rate-limiting enzyme ornithine decarboxylase (ODC1). In vitro and in vivo studies demonstrated that exogenous supplementation with the polyamine putrescine or its biosynthetic substrate, ornithine, enhanced ILC3 production of IL-22. Conditional deletion of ODC1 in ILC3s impaired mouse antibacterial defense against
Citrobacter rodentium
infection, which was associated with a decrease in anti-microbial peptide production by the intestinal epithelium. Furthermore, in a model of anti-CD40 colitis, deficiency of ODC1 in ILC3s markedly reduced the production of IL-22 and severity of inflammatory colitis. We conclude that ILC3-intrinsic polyamine biosynthesis facilitates efficient defense against enteric pathogens as well as exacerbates autoimmune colitis, thus representing an attractive target to modulate ILC3 function in intestinal disease.
Precision calculation of neutrino evolution in the early Universe
Authors: Froustey Julien 
Published: October 2022

Abstract
In the primordial Universe, neutrino decoupling occurs only slightly before electron-positron annihilations. This leads notably to an increased neutrino energy density compared to the standard instantaneous decoupling approximation, parametrized by the effective number of neutrino species N
eff. A precise calculation of neutrino evolution is needed to assess its consequences during the later cosmological stages, and requires to take into account multiple effects such as neutrino oscillations, which represents a genuine numerical challenge. Recently, several key improvements have allowed such a precise numerical calculation, leading to the new reference value N
eff = 3.0440.
The health halo effect of ‘low sugar’ and related claims on alcoholic drinks: an online experiment with young women
Authors: Cao Shuyan , Tang Changyuan , Carboon Isla , Hayward Cassie , Capes Hannah , Chen Yan Jun Michelle , Brennan Emily , Dixon Helen , Wakefield Melanie , Haynes Ashleigh 
Published: October 2022

AbstractAimsTo investigate whether ‘low sugar’ and related claims influence consumers’ perceptions of the healthiness or other attributes of alcoholic drinks, promote greater consumption or impact diet and activity behaviour intentions.MethodN = 501 Australian women aged 18–35 viewed and rated six images of alcoholic drinks in a randomized online experiment with a 2 (claim: low sugar claim, no claim control) × 2 (drink type: cider, ready-to-drink spirits) between-subjects design.ResultsParticipants who viewed drinks with low sugar claims rated them as healthier, less harmful to health, lower in sugar and kilojoules, and more suitable for weight management and a healthy diet than participants who viewed identical drinks with no claim (P &lt; 0.001-P = 0.002). Drinks with low sugar claims were also perceived as being lower in alcohol (P &lt; 0.001) despite being of equivalent alcohol content. There were no significant differences in anticipated social approval associated with consumption or in hypothetical intended consumption of the drinks, but participants who viewed drinks with low sugar claims were less likely to indicate they would compensate for consumption of the drink by modifying food intake or physical activity (P = 0.01).ConclusionsLow sugar and related claims on alcoholic drinks can generate a health halo: consumers generalise from a specific favourable attribute (low sugar) to misperceive other favourable health- and nutrition-related attributes, including lower alcohol content. Findings support calls to reconsider the permissibility of low sugar claims on alcoholic drinks as they may mislead consumers.
Mutations in the WLS are associated with dental anomalies, torus palatinus, and torus mandibularis
Authors: Kantaputra Piranit , Tripuwabhrut Kanich , Jatooratthawichot Peeranat , Adisornkanj Ploy , Hatsadaloi Athiwat , Porntrakoolsaree Nop , Kaewgaya Massupa , Olsen Bjorn , Tongsima Sissades , Ngamphiw Chumpol , Ketudat Cairns James R 
Published: October 2022

Summary

Background
Canonical and non-canonical WNT signaling are important for odontogenesis. WNT ligand secretion mediator (WLS; MIM611514) is required to transport lipid-modified WNT proteins from the Golgi to the cell membrane, where canonical and non-canonical WNT proteins are released into the extracellular milieu. Biallelic pathogenic variants in WLS are implicated in autosomal recessive Zaki syndrome (ZKS; MIM 619648), the only genetic condition known to be caused by pathogenic variants in WLS.

Objective
To investigate molecular etiology of dental anomalies in 250 patients with or without oral exostoses.

Patients and methods
Clinical and radiographic examination, and whole exome sequencing, were performed in the case of 250 patients with dental anomalies with or without oral exostoses.

Results
Four extremely rare heterozygous missense variants (p.Ile20Thr, p.Met46Leu, p.Ser453Ile and p.Leu516Phe) in WLS were identified in 11 patients with dental anomalies. In five of these patients, a torus palatinus or a torus mandibularis was observed.

Conclusion
We report for the first time the heterozygous WLS variants in patients with dental anomalies. Root maldevelopments in patients with WLS variants supports the role of canonical and non-canonical WNT signaling in root development. We also show that variants in WLS were implicated in torus palatinus and torus mandibularis. In addition, this is the first time that heterozygous carriers of WLS variants were found to manifest phenotypes. WLS variants were likely to have adverse effects on the concentration of WNT ligands delivered to the cell membrane, resulting in aberrant canonical and non-canonical WNT signaling, and subsequent phenotypes.

Limitations of the study
Patient’s positioning during the acquisition of panoramic radiography might have affected the appearance of the tooth structures. If we had all family members of each patient to study co-segregation between genotype and phenotype, it would have strengthened the association of WLS variants and the phenotypes.
Genomic characterization of antifungal Acinetobacter bacteria isolated from the skin of the frogs Agalychnis callidryas and Craugastor fitzingeri
Authors: Cevallos M A , Basanta M D , Bello-López E , Escobedo-Muñoz A S , González-Serrano F M , Nemec A , Romero-Contreras Y J , Serrano M , Rebollar E A 
Published: October 2022

Abstract
Chytridiomycosis, a lethal fungal disease caused by Batrachochytrium dendrobatidis (Bd), is responsible for population declines and extinctions of amphibians worldwide. However, not all amphibian species are equally susceptible to the disease; some species persist in Bd enzootic regions with no population reductions. Recently, it has been shown that the amphibian skin microbiome plays a crucial role in the defense against Bd. Numerous bacterial isolates with the capacity to inhibit the growth of Batrachochytrium fungi have been isolated from the skin of amphibians. Here, we characterized eight Acinetobacter bacteria isolated from the frogs Agalychnis callidryas and Craugastor fitzingeri at the genomic level. A total of five isolates belonged to Acinetobacter pittii,Acinetobacter radioresistens, or Acinetobactermodestus, and three were not identified as any of the known species, suggesting they are members of new species. We showed that seven isolates inhibited the growth of Bd and that all eight isolates inhibited the growth of the phytopathogen fungus Botrytis cinerea. Finally, we identified the biosynthetic gene clusters that could be involved in the antifungal activity of these isolates. Our results suggest that the frog skin microbiome includes Acinetobacter isolates that are new to science and have broad antifungal functions, perhaps driven by distinct genetic mechanisms.
Early delivery following chronic and acute ambient temperature exposure: a comprehensive survival approach
Authors: Hough Ian , Rolland Matthieu , Guilbert Ariane , Seyve Emie , Heude Barbara , Slama Rémy , Lyon-Caen Sarah , Pin Isabelle , Chevrier Cécile , Kloog Itai , Lepeule Johanna 
Published: October 2022

Abstract

Background
Ambient temperature, particularly heat, is increasingly acknowledged as a trigger for preterm delivery but study designs have been limited and results mixed. We aimed to comprehensively evaluate the association between ambient temperature throughout pregnancy and preterm delivery.

Methods
We estimated daily temperature throughout pregnancy using a cutting-edge spatiotemporal model for 5347 live singleton births from three prospective cohorts in France, 2002–2018. We performed Cox regression (survival analysis) with distributed lags to evaluate time-varying associations with preterm birth simultaneously controlling for exposure during the first 26 weeks and last 30 days of pregnancy. We examined weekly mean, daytime, night-time and variability of temperature, and heatwaves accounting for adaptation to location and season.

Results
Preterm birth risk was higher following cold (5th vs 50th percentile of mean temperature) 7–9 weeks after conception [relative risk (RR): 1.3, 95% CI: 1.0–1.6 for 2°C vs 11.6°C] and 10–4 days before delivery (RR: 1.6, 95% CI: 1.1–2.1 for 1.2°C vs 12.1°C). Night-time heat (95th vs 50th percentile of minimum temperature; 15.7°C vs 7.4°C) increased risk when exposure occurred within 5 weeks of conception (RR: 2.0, 95% CI: 1.05–3.8) or 20–26 weeks after conception (RR: 2.9, 95% CI: 1.2–6.8). Overall and daytime heat (high mean and maximum temperature) showed consistent effects. We found no clear associations with temperature variability or heatwave indicators, suggesting they may be less relevant for preterm birth.

Conclusions
In a temperate climate, night-time heat and chronic and acute cold exposures were associated with increased risk of preterm birth. These results suggest night-time heat as a relevant indicator. In the context of rising temperatures and more frequent weather hazards, these results should inform public health policies to reduce the growing burden of preterm births.