bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perancangan Sistem Pipa Pertukaran Air Ballas Metode Flow-Through pada Kapal SPOB 8500 KL
Authors: Setiawan Wira setiawan, S.T., M.T 
Published: May 2022

Abstrak International Maritime Organization telah mengatur pengelolaan air ballas, dan salah satu metode pertukaran air ballas yang diakui adalah metode flow-through. Secara umum metode ini melakukan pertukaran air ballas dengan memompa paksa air ballas pengganti sekitar tiga kali dari kapasitas tangki dan akan keluar melalui luapan. Sistem ini dapat menjadi bagian dari sistem ballas pada umumnya sehingga diperlukan perancangan yang komprehensif termasuk dalam penentuan pipe support. Perancangan sistem ballas pada kapal SPOB 8500 KL ini diawali dengan penentuan ukuran pipa dan kapasitas pompa yang digunakan, lalu dilanjutkan dengan pemodelan 3 dimensi dengan bantuan software autopipe untuk menganalisis tegangan pada jalur perpipaan serta mengetahui jumlah komponen sistem perpipaan yang akan digunakan. Setelah dilakukan proses perhitungan, maka diperoleh diameter pipa ballas dengan NPS 125mm, ID 122.55 mm, OD 141.3 mm, dengan ketebalan 9.525 mm. Adapun kapasitas pompa adalah sebesar 86 m3/jam dengan head pompa senilai 58.1 meter. Pada tahap analisis kekuatan pipa diperoleh tegangan paling tinggi berada pada node 59 sebesar 30432.04 N/mm2, dan setelah dilakukan penambahan pipe support nilai tegangan dapat diturunkan menjadi 6.05 N/mm2 sehingga semua titik-titik pada sistem berada di bawah nilai tegangan izin berdasarkan allowable pipe span pada batasan defleksi. Sedangkan jumlah material yang dibutuhkan diketahui sebanyak 80 unit pipa dengan panjang 6 meter, pipe support tipe shoe (127 unit), tipe rod hanger (28 unit) dan tipe U-Bent (2 unit), gate valve (32 unit), SDNR valve (10 unit), Slip-on flange (84 unit), Strainer (2 unit), elbow ( 84 unit), t-joint (38 unit) dan bellmouth (12 unit).
DERAJAT FIBROSIS DAN NAS PADA HEPAR TIKUS DIABETES MELLITUS TIPE 2 REMAJA
Authors: Ramadan Mohamad Alif , Pramaningtyas Miranti Dewi , Lusiantari Rokhima 
Published: May 2022

Diabetes melitus merupakan penyakit kronis ditandai dengan peningkatan glukosa darah. Prevalensi diabetes mellitus tipe 2 pada pada anak-anak dan remaja 6,5%. Kondisi Diabetes Mellitus tipe 2 dapat menyebabkan gangguan NAFLD hingga NASH. Tujuan Penelitian ini untuk mengetahui efek diabetes melitus tipe 2 terhadap gambaran fibrosis dan skor NAFLD pada histologi hepar tikus remaja. Penelitian ini menggunakan desain post-test only control group. Kelompok perlakuan diinduksi diet tinggi lemak 2 minggu dan streptozotosin. Kelompok kontrol positif diberi streptozotosin dan kelompok kontrol negatif diberi pakan standar. Organ hepar dibuat preparat histopatologi dengan pewarnaan Hematoksilin Eosin (HE). Pembacaan preparat berdasarkan kriteria NAFLD activity score (NAS) dan derajat fibrosis. Analisis data menggunakan Kruskal-Wallis Test dengan post-hoc Mann-Whitney U. Hasil pengamatan histopatologi hepar dengan kriteria NAS 1.80 ± 0.447 (K-), 2.20 ± 0.447 (K+), dan 1.60 ± 0.548 (P). Rata-rata hasil terkait derajat fibrosis 1.00 ± 0.000 (K-), 1.60 ± 0.894 (K+), dan 1.00 ± 1.000 (P). Hasil analisis perbandingan kriteria NAS antar kelompok tidak signifikan (p>0,05) dan begitu juga dengan fibrosis tidak signifikan (p>0,05). Kesimpulan penelitian ini tidak terdapat hubungan yang bermakna antara diabetes mellitus tipe 2 dengan gambaran histopatologi hepar pada tikus remaja.
GAMBARAN TINGKAT PENGETAHUAN TENTANG PENTINGNYA KONSUMSI SERAT UNTUK MENCEGAH KONSTIPASI PADA MASYARAKAT KELURAHAN RENGAS CONDONG KECAMATAN MUARA BULIAN /KABUPATEN BATANGHARI PROVINSI JAMBI
Authors: Amanda Elsa Nadhia , Anggraini Debie , Hasni Dita , Jelmila Sri Nani 
Published: May 2022

Background: Dietary fiber is part of food in the form of complete carbohydrates found in plant cell walls and can be consumed by the body. People who consume low fiber will slow down the transit time of food in the intestine which will cause constipation. Constipation is the sensation or desire to have a bowel movement, feeling dissatisfied with bowel movements, pain, needing extra pressure or having a hard bowel movement. Constipation is also said to be in everyday situations when defecating is less than 3 times a week and defecating is required by straining excessively. Objective: To describe the level of knowledge about the importance of fiber consumption to prevent constipation in the people of Rengas Condong Village, Muara Bulian District Batanghari Regency, Jambi Province in 2021. Methods: The type of research used is descriptive with a crosssectional approach. The affordable population in this study were the people of Rengas Condong Village, Muara Bulian District, Batanghari Regency, Jambi Province with 148 samples using simple random sampling. Univariate data analysis is presented in the form of frequency distribution and percentage and data processing using the computerized SPSS version 25.0 program. Results: Most errors in knowledge are in statement number 8, namely water-soluble fiber is easily digested (89.9%), the most gender were male, namely 76 people (51.4%) and the most recent age was late adulthood, namely 37 people (25.0%), and the highest level of knowledge was moderate, namely 101 people (68.2%) Conclusion: Error The most knowledge in statement number 8 is that water-soluble fiber is easy to digest, the most sexes are male and the age at most is late adulthood, and the most knowledge level is moderate.
De libros prohibidos, datos y políticas culturales. Cuantificar el impacto de las bibliotecas
Authors: Ruiz Ruiz David 
Published: May 2022

Las bibliotecas públicas tienen un impacto económico y social en la sociedad y contamos con mecanismos y herramientas para medirlo, de manera que los gastos en bibliotecas suponen una inversión cuyo retorno es perfectamente cuantificable. Para ello nos acercamos al estudio que se hizo en 2016 en el marco de las bibliotecas de Navarra El valor de las bibliotecas y accesible desde la web http://www.elvalordelasbibliotecas.es/. Este trabajo ofrece una herramienta práctica para que tanto las bibliotecas puedan calcular su rentabilidad como para que los usuarios puedan acceder al “coste” de los servicios usados.
No obstante, el análisis cuantitativo del coste no puede hacernos perder la perspectiva de la función social de las bibliotecas como espacios de libertad que hemos de garantizar en un momento en el que parece que ésta se está “cercenando” en algunos espacios determinados a raíz de ciertas prohibiciones de libros.
PENGEMBANGAN LEMBAR KERJA SISWA BERBASIS CORE (CONNECTING, ORGANIZING, EXTENDING, DAN REFLECTING) PADA MATERI SISTEM PERSAMAAN LINIER DUA VARIABEL
Authors: Zamzam Kenys Fadhilah , Hamandika Orvinus Ndilu 
Published: May 2022

Student worksheets (LKS) are student guides in solving problems. LKS based on CORE (Connecting, Organizing, Extending, and Reflecting) on the material of a two-variable equation system had advantages in presenting the material and had an attractive appearance. The development model used ADDIE model. The subjects of this study were 20 students of SMAN 1 Nggaha Ori Angu. The data collection process used an instrument in the form of a validation sheet with the aim of measuring the validity of the LKS, post-test to determine student learning outcomes and student responses to the LKS developed to determine the effectiveness of the LKS. The results of data analysis showed that from the two validators the average value was 3.32 which showed the valid criteria. The percentage of students' average completeness score was 78%. Based on the established criteria, it can be said that students had good mastery of the SPLDV material. The student response questionnaire data obtained a percentage of 85.7%, so based on the criteria it was concluded that students showed a positive response to the developed LKS. Overall, the CORE-based LKS on SPLDV material was effectively used in the learning process.
Pendampingan Pengelolaan Ibu Hamil dengan Kekurangan Energi Kronik dan Bayi Berisiko Stunting
Authors: Anis Setyowati  , Ratnawati Lina , Sholichah Rizka Mar’atus 
Published: May 2022

Pregnant women with Chronic Energy Deficiency and low nutrition knowledge are at risk of pregnancy with anemia. Inhibited fetal growth (IPM) and LBW delivery can increase the risk of stunting. The purpose of this activity was to deal with SEZ problems in pregnant women, babies who are at risk of stunting, and lack of nutrition knowledge. The method used was assistance to pregnant women with Chronic Energy Deficiency until the mother gives birth by providing additional foods high in calories and protein, iron, calcium and folic acid supplementation, as well as education through lectures and discussions. The location was in Puncu District, Kediri Regency with 37 pregnant women with Chronic Energy Deficiency with gestational age of 23-40 weeks. There was an increase in the average weight of pregnant women by 8.9 kg, uterine fundal height increased by an average of 14.06 cm, upper arm circumference increased by an average of 3.9 cm, Hb levels increased by an average of 1.74gr%, Mother's knowledge about nutrition and exclusive breastfeeding increased, breastfeeding skills increased, the baby's weight and upper arm circumference were in the normal category. Assistance for pregnant women with Chronic Energy Deficiency and babies at risk of stunting can improve maternal health during pregnancy and prevent babies from experiencing stunting.

ABSTRAK
Ibu hamil dengan status gizi KEK dan pengetahuan rendah tentang gizi berisiko terhadap kehamilan dengan anemia. Pertumbuhan janin terhambat (PJT) dan persalinan BBLR dapat meningkatkan risiko stunting pada bayi. Tujuan kegiatan ini adalah menangani masalah KEK pada ibu hamil, bayi yang berisiko stunting, rendahnya pengetahuan tentang gizi. Metode yang digunakan adalah pendampingan kepada ibu hamil KEK sampai ibu melahirkan dan bayinya berusia 3 bulan dengan memberikan makanan tambahan tinggi kalori dan protein, suplementasi tablet tambah darah, kalsium dan asam folat, serta edukasi dengan ceramah dan diskusi. Lokasi di Kecamatan Puncu Kabupaten Kediri dengan 37 ibu hamil KEK dengan usia kehamilan 23-40 minggu. Terdapat peningkatan rerata berat badan ibu hamil sebesar 8,9 kg, tinggi fundus uteri meningkat rata-rata sebesar 14,06 cm, lingkar lengan atas meningkat rata-rata 3,9 cm, kadar Hb meningkat rata-rata sebesar 1,74gr%, pengetahuan ibu tentang gizi dan ASI Eksklusif meningkat, keterampilan menyusui meningkat, berat badan dan lingkar lengan atas bayi dalam kategori normal. Pendampingan ibu hamil KEK dan bayi berisiko stunting dapat meningkatkan kesehatan ibu selama kehamilan dan mencegah bayi mengalami stunting.
A One-Step Electrochemical Aptasensor Based on Signal Amplification of Metallo Nanoenzyme Particles for Vascular Endothelial Growth Factor
Authors: Mei ChenYang , Zhang Yuanyuan , Pan Luting , Dong Bin , Chen Xingwei , Gao Qingyi , Xu Hang , Xu Wenjin , Fang Hui , Liu Siyu , McAlinden Colm , Paschalis Eleftherios I. , Wang Qinmei , Yang Mei , Huang Jinhai , Yu A-Yong 
Published: May 2022

In this study, a one-step electrochemical aptasensor was developed to detect the biomarker vascular endothelial growth factor (VEGF), an important protein in the pathogenesis of many retinal diseases, including age-related macular degeneration, diabetic retinopathy, retinopathy of prematurity, and retinal vein occlusion. The aptamer has a good affinity and can rapidly identify and capture VEGF based on its unique structure. We designed a VEGF aptasensor based on the aptamer recognition and complex metallo nanoenzyme particles as an electron exchange center and bridge between capture DNA and electrode. The aptamers maintained the hairpin structure to avoid nonspecific surface adsorption and expose the capture sequence outwards when the target was inexistent. Conversely, the aptamers opened the hairpin structure to release space to accomplish binding between VEGF and DNA, resulting in increased impedance. The performance of the electrochemical aptasensor is detected by electrochemical impedance spectroscopy (EIS). The limit of detection by EIS was as low as 8.2 pg ml−1, and the linear range was 10 pg ml−1–1 μg ml−1. The electrochemical aptasensor also showed high specificity and reproducibility.
Topographic Response of Hinterland Basins in Tibet to the India–Asia Convergence: 3D Thermo-Mechanical Modeling
Authors: Zhang Pengpeng , Chen Lin , Xiao Wenjiao , Zhang Ji’en 
Published: May 2022

A number of basins have developed in Tibet since the early stages of the India–Asia collision, and now, they have become integral parts of the Tibetan Plateau. Geophysical and geochemical data reveal that these basins are currently characterized either by strong or weak basements. However, it remains unclear how these hinterland basins evolved during the India–Asia collision and how they affected the post-collisional growth of the Tibetan Plateau. Here, we use 3D thermo-mechanical simulations to investigate the topographic response of a strength-varying hinterland basin imbedded in an orogenic plateau under the horizontal compression condition. Our results show that a strong hinterland basin experiences little deformation and develops into a lowland with respect to the surrounding plateau at the early stages of the collision. The lowland gradually shrinks and survives in the interior of the plateau for ∼30–40 Myr before merging into the plateau. In contrast, a weak hinterland basin uplifts soon after the initial collision and develops into a highland after ∼20 Myr of convergence. Topographic analysis reveals that the strong hinterland basin experiences an evident elevation drop after ∼20–30 Myr of convergence, followed by a rapid uplift. After compiling the paleoelevation data, we proposed that the Tibetan Plateau experienced a four-stage surface uplift, which was characterized by 1) the Gangdese and central watershed highlands isolating three lowlands during the Eocene, 2) the central lowland experiencing an elevation drop of ∼2000 m during the Oligocene, 3) the central lowland suffering a rapid uplift and merging into the Tibetan Plateau in the Early Miocene, and 4) the south and north lowlands rising and developing into a plateau similar to the modern Tibetan Plateau since the Middle Miocene.
Sedimentary Hydrodynamic Processes Under Low-Oxygen Conditions: Implications for Past, Present, and Future Oceans
Authors: Bruni Elena T. , Blattmann Thomas M. , Haghipour Negar , Louw Deon , Lever Mark , Eglinton Timothy I. 
Published: May 2022

Continental margin sediments represent a major global sink of organic carbon (OC), and as such exert a key control on Earth’s climate. Today, OC burial in marine sediments mainly takes place under oxygen-rich water columns, where most OC is stabilized through intimate association with sediment grains and biogenic minerals. In prior episodes of Earth’s past, when large parts of the oceans were anoxic, the mode of sedimentary OC burial must have been very different, however. Present-day analogues indicate that surface sediments accumulating under low-oxygen water columns are often “soupy” in texture. Moreover, most OC occurs in large (100–2,000 μm diameter) organic and organo-mineral aggregates which, due to their low density, are prone to wave- and current-induced resuspension. Upon mobilization, these aggregates can undergo lateral transport within so-called nepheloid layers, and may be translocated hundreds of kilometres, and on timescales of thousands of years. Little is known about processes of formation, resuspension and hydrodynamic properties of these aggregates in oxygen-poor waters, or which factors control their eventual breakdown or burial. The goal of this study is to examine the drivers and biogeochemical consequences of this resuspension on OC cycling in modern, oxygen-depleted, “Semi-Liquid Ocean Bottom” (SLOB) regions. We argue that models of sediment and OM hydrodynamics and redistribution that describe sedimentation processes in oxygenated ocean waters of the modern ocean are a poor analogue for equivalent processes occurring under oxygen-deficient conditions. In the latter, we hypothesize that 1) the abundance of low-density organic-rich particles and aggregates leads to a greater propensity for sediment remobilization at low(er) shear stress, and 2) upon resuspension into low-oxygen bottom waters, remobilized OM may be subject to less degradation (less attenuation) during lateral transport, leading to efficient and widespread translocation to distal centres of deposition. We address specific aspects of the SLOB hypothesis utilizing a combination of literature and new data, focussing on the Benguela Upwelling Region as a model system.
Antithymocyte Globulin as Second-Line Therapy in Graves Orbitopathy—Preliminary Results From a Prospective Single-Center Study
Authors: Sarnat-Kucharczyk Monika , Świerkot Maria , Handzlik Gabriela , Kulawik Grażyna , Jagoda Krystyna , Grochoła-Małecka Iga , Fryżewska Joanna , Mrukwa-Kominek Ewa , Chudek Jerzy 
Published: May 2022

ObjectiveManagement of Graves’ orbitopathy remains a challenge. Our previous case report has shown promising results for rabbit antithymocyte globulin (rATG) in the treatment of Graves’ orbitopathy.DesignWe present the response of 7 individuals with active moderate-to-severe steroid-resistant Graves’ orbitopathy to rATG, representing preliminary results from a prospective single-center study.MethodsrATG was administered intravenously at a dose of 0.8–1.0 mg/kg daily (cumulative dose of 150–200 mg). The primary outcome measures at weeks 24 and 48 were ≥2-point reduction in Clinical Activity Score from baseline, a proptosis response, a diplopia response, and improvement of distant best-corrected visual acuity and mean retinal sensitivity. Key secondary outcomes included stabilization of ganglion cell complex thickness, a decrease of retinal nerve fiber layer in OCT, and a reduction in CD4/CD8 ratio and TRAb at 48 weeks.ResultsAn improvement in clinical activity score was observed in all patients, with disease inactivation in 3 cases. Proptosis reduction equal to or greater than 2 mm was noted for 8 of 10 eyes. Diplopia improved in three of 6 patients. There was an improvement in best-corrected visual acuity (from 0.69 to 0.78) and mean retinal sensitivity (from 20.8 to 23.5 dB). In addition, there was a long-lasting improvement in CD4/CD8 ratio in 6 patients. Two patients experienced adverse events (influenza and serum sickness).ConclusionrATG therapy offers a long-lasting improvement in moderate-to-severe steroid-resistant Graves’ orbitopathy with improvement in functional vision (reduction of diplopia, improvement of visual acuity, retinal sensitivity, and VEP pattern). The therapy is well-tolerated.Clinical Trial RegistrationClinicalTrials.gov, identifier NCT05199103.
Technical Performance Optimization of a Novel Geothermal Hybrid Power Generation System
Authors: Zhou Ying , Qin Jiyun , Hu Eric , Zhang Qinglei 
Published: May 2022

Geothermal Aided Power Generation (GAPG) technology is a geothermal hybrid power system that geothermal energy has been integrated into the fossil fired plant to preheat the feedwater, and displace the extraction steam of fossil fired plant. In such a power system, the heat exchange process between extraction steam and geo-fluid occurs in a heat exchange between. When the geo-fluid in the heat exchanger quench to lower temperature for heat transfer purpose, silica scaling would occur in the heat exchanger system. The performance of the GAPG plant would be influenced by the configuration of the heat exchanger and silica scaling in the heat exchanger. For a GAPG plant, it has two possible configurations for a heat exchanger system: series arrangement and parallel arrangement. The different configuration also impacts on the technical performance of the GAPG plant. The silica scaling in the heat exchanger system would harm the performance of the GAPG plant. In this study, a GAPG power system from a 300 MW power plant is used as a case study to understand the impact of displacement selections and heat exchanger arrangement on the performance of the GAPG plant. It was found that there is no silica scaling occurring in heat exchangers system if geo-fluid is used to displace to high-grade extraction steam only. Furthermore, the Parallel arrangement is better than the Series arrangement in terms of the additional power output. Moreover, the GAPG plant has protentional to reduce carbon dioxide emissions by 13%.
N6-Methyladenosine-Related lncRNAs Are Novel Prognostic Markers and Predict the Immune Landscape in Acute Myeloid Leukemia
Authors: Zhang Lulu , Ke Wen , Hu Pin , Li Zhangzhi , Geng Wei , Guo Yigang , Song Bin , Jiang Hua , Zhang Xia , Wan Chucheng 
Published: May 2022

Background: Acute myelocytic leukemia (AML) is one of the hematopoietic cancers with an unfavorable prognosis. However, the prognostic value of N 6-methyladenosine-associated long non-coding RNAs (lncRNAs) in AML remains elusive.Materials and Methods: The transcriptomic data of m6A-related lncRNAs were collected from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) database. AML samples were classified into various subgroups according to the expression of m6A-related lncRNAs. The differences in terms of biological function, tumor immune microenvironment, copy number variation (CNV), and drug sensitivity in AML between distinct subgroups were investigated. Moreover, an m6A-related lncRNA prognostic model was established to evaluate the prognosis of AML patients.Results: Nine prognosis-related m6A-associated lncRNAs were selected to construct a prognosis model. The accuracy of the model was further determined by the Kaplan–Meier analysis and time-dependent receiver operating characteristic (ROC) curve. Then, AML samples were classified into high- and low-risk groups according to the median value of risk scores. Gene set enrichment analysis (GSEA) demonstrated that samples with higher risks were featured with aberrant immune-related biological processes and signaling pathways. Notably, the high-risk group was significantly correlated with an increased ImmuneScore and StromalScore, and distinct immune cell infiltration. In addition, we discovered that the high-risk group harbored higher IC50 values of multiple chemotherapeutics and small-molecule anticancer drugs, especially TW.37 and MG.132. In addition, a nomogram was depicted to assess the overall survival (OS) of AML patients. The model based on the median value of risk scores revealed reliable accuracy in predicting the prognosis and survival status.Conclusion: The present research has originated a prognostic risk model for AML according to the expression of prognostic m6A-related lncRNAs. Notably, the signature might also serve as a novel biomarker that could guide clinical applications, for example, selecting AML patients who could benefit from immunotherapy.