bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peer Navigation to Support Transgender Women’s Engagement in HIV Care: Findings from the Trans Amigas Pilot Trial in São Paulo, Brazil
Authors: Lippman Sheri A. , Sevelius Jae M. , Saggese Gustavo Santa Roza , Gilmore Hailey , Bassichetto Katia Cristina , de Barros Daniel Dutra , de Oliveira Renata Batisteli , Maschião Luca Fasciolo , Chen Dorothy , de Sousa Mascena Veras Maria Amelia 
Published: February 2022

AbstractTrans women living with HIV (TWH) have suboptimal HIV care engagement. We pilot tested Trans Amigas, a theory-based, trans-specific peer navigation (PN) intervention to address barriers to care in São Paulo, Brazil. TWH were randomized to the PN intervention (n = 75) or control (n = 38) condition. Control participants were referred to trans-friendly HIV care. Intervention participants were assigned a navigator who conducted nine in-person one-on-one sessions and bi-weekly phone or text check-ins to help participants overcome barriers to care and work towards gender affirmation and healthcare goals. We followed participants for 9 months to determine intervention feasibility, acceptability, and preliminary efficacy in improving retention in care. Analyses were intention to treat (ITT). Intervention acceptability was high: at end line, 85.2% of PN participants said they would continue receiving services and 94.4% would recommend peer navigation to a friend. A priori feasibility criteria were met: 92% of eligible participants enrolled and 70% were retained at 9 months; however, only 47% achieved moderate or better adherence to both in-person and phone/text program components. Though the pilot was not powered for efficacy, ITT findings trended toward significance, with intervention participants 40% more likely to be retained in care at the end of the study. Population-specific peer programming to support care engagement is acceptable, feasible, and can improve HIV outcomes for Trans women living with HIV.
Internal Deliberation Defending Climate-Harmful Behavior
Authors: Wolrath Söderberg Maria , Wormbs Nina 
Published: February 2022

AbstractMost people in countries with the highest climate impact per capita are well aware of the climate crisis and do not deny the science. They worry about climate and have climate engaged attitudes. Still, their greenhouse-gas emissions are often high. How can we understand acting contrary to our knowledge? A simple answer is that we do not want to give up on benefits or compromise our quality of life. However, it is painful to live with discrepancies between knowledge and action. To be able to avoid taking the consequences of our knowledge, we deal with the gap by motivating to ourselves that the action is still acceptable. In this article, we use topical analysis to examine such processes of motivation by looking at the internal deliberation of 399 climate engaged people’s accounts of their reasoning when acting against their own knowledge. We found that these topical processes can be described in at least four different ways which we call rationalization, legitimization, justification and imploration. By focusing on topoi we can make visible how individual forms of reasoning interact with culturally developed values, habits and assumptions in creating enthymemes. We believe that these insights can contribute to understanding the conditions for climate transition communication.
The combination of Neosartorya (Aspergillus) fischeri antifungal proteins with rationally designed γ-core peptide derivatives is effective for plant and crop protection
Authors: Tóth Liliána , Poór Péter , Ördög Attila , Váradi Györgyi , Farkas Attila , Papp Csaba , Bende Gábor , Tóth Gábor K. , Rákhely Gábor , Marx Florentine , Galgóczy László 
Published: February 2022

AbstractPlant pathogenic fungi are responsible for enormous crop losses worldwide. Overcoming this problem is challenging as these fungi can be highly resistant to approved chemical fungicides. There is thus a need to develop and introduce fundamentally new plant and crop protection strategies for sustainable agricultural production. Highly stable extracellular antifungal proteins (AFPs) and their rationally designed peptide derivatives (PDs) constitute feasible options to meet this challenge. In the present study, their potential for topical application to protect plants and crops as combinatorial biofungicides is supported by the investigation of two Neosartorya (Aspergillus) fischeri AFPs (NFAP and NFAP2) and their γ-core PDs. Previously, the biofungicidal potential of NFAP, its rationally designed γ-core PD (γNFAP-opt), and NFAP2 was reported. Susceptibility tests in the present study extended the in vitro antifungal spectrum of NFAP2 and its γ-core PD (γNFAP2-opt) to Botrytis, Cladosporium, and Fusarium spp. Besides, in vitro additive or indifferent interactions, and synergism were observed when NFAP or NFAP2 was applied in combination with γNFAP-opt. Except for γNFAP2-opt, the investigated proteins and peptides did not show any toxicity to tomato plant leaves. The application of NFAP in combination with γNFAP-opt effectively inhibited conidial germination, biofilm formation, and hyphal extension of the necrotrophic mold Botrytis cinerea on tomato plant leaves. However, the same combination only partially impeded the B. cinerea-mediated decay of tomato fruits, but mitigated the symptoms. Our results highlight the feasibility of using the combination of AFP and PD as biofungicide for the fungal infection control in plants and crops.
Surprisingly high economic costs of biological invasions in protected areas
Authors: Moodley Desika , Angulo Elena , Cuthbert Ross N. , Leung Brian , Turbelin Anna , Novoa Ana , Kourantidou Melina , Heringer Gustavo , Haubrock Phillip J. , Renault David , Robuchon Marine , Fantle-Lepczyk Jean , Courchamp Franck , Diagne Christophe 
Published: February 2022

AbstractBiological invasions are one of the main threats to biodiversity within protected areas (PAs) worldwide. Meanwhile, the resilience of PAs to invasions remains largely unknown. Consequently, providing a better understanding of how they are impacted by invasions is critical for informing policy responses and optimally allocating resources to prevention and control strategies. Here we use the InvaCost database to address this gap from three perspectives: (i) characterizing the total reported costs of invasive alien species (IAS) in PAs; (ii) comparing mean observed costs of IAS in PAs and non-PAs; and (iii) evaluating factors affecting mean observed costs of IAS in PAs. Our results first show that, overall, the reported economic costs of IAS in PAs amounted to US$ 22.24 billion between 1975 and 2020, of which US$ 930.61 million were observed costs (already incurred) and US$ 21.31 billion were potential costs (extrapolated or predicted). Expectedly, most of the observed costs were reported for management (73%) but damages were still much higher than expected for PAs (24%); in addition, the vast majority of management costs were reported for reactive, post-invasion actions (84% of management costs, focused on eradication and control). Second, differences between costs in PAs and non-PAs varied among continents and environments. We found significantly higher IAS costs in terrestrial PA environments compared to non-PAs, while regionally, Europe incurred higher costs in PAs and Africa and Temperate Asia incurred higher costs in non-PAs. Third, characterization of drivers of IAS costs within PAs showed an effect of environments (higher costs in terrestrial environments), continents (higher in Africa and South America), taxa (higher in invertebrates and vertebrates than plants) and Human Development Index (higher in more developed countries). Globally, our findings indicate that, counterintuitively, PAs are subject to very high costs from biological invasions. This highlights the need for more resources to be invested in the management of IAS to achieve the role of PAs in ensuring the long term conservation of nature. Accordingly, more spatially-balanced and integrative studies involving both scientists and stakeholders are required.
Mechanistic investigation of the effect of endoglucanases related to pulp refining
Authors: Nagl Martin , Haske-Cornelius Oskar , Skopek Lukas , Bausch Florian , Pellis Alessandro , Bauer Wolfgang , Nyanhongo Gibson S. , Guebitz Georg M. 
Published: February 2022

AbstractEndoglucanases are increasingly being touted as the ultimate solution for reducing energy consumption during the refining process in the pulp and paper industry. However, due to the high variety of endoglucanases in different enzyme formulations, these perform heterogeneously when applied to different pulps. In this study, the effect of four endoglucanases on softwood and hardwood pulp was studied using confocal laser scanning microscopy (CLSM) after addition of fluorescently labelled carbohydrate binding modules (CBMs). Nuclear magnetic resonance (NMR) analysis and high-performance liquid chromatography quantification of released oligo- and monosaccharides was performed for in-depth mechanistical investigation. Changes in the crystallinity levels caused by enzymatic degradation of amorphous regions were monitored by incubation with two different CBMs from Caldicellulosiruptor bescii and from Thermobifida fusca with high preference to either amorphous or crystalline regions of cellulose, respectively. When dosed at identical activity on the endoglucanase specific CellG5 substrate, CLSM analysis indicated the highest decrease of amorphous regions for those endoglucanases which were also most active in laboratory refining trials and which released highest amounts of cellooligomers from pulp. Using 13C-NMR analysis, an increase in para-crystalline cellulose caused by enzyme application was observed. Release of reducing sugars was determined at identical CellG5 dosage, indicating a high variance between the enzymes, especially when complex enzyme formulations were used. Scanning electron microscopy images were obtained for visualization of the endoglucanase activity. The results of mechanistical studies indicate that reduction of amorphous moieties of pulp by endoglucanases is especially beneficial for the refining process.
A federated approach to Android malware classification through Perm-Maps
Authors: D’Angelo Gianni , Palmieri Francesco , Robustelli Antonio 
Published: February 2022

AbstractIn the last decades, mobile-based apps have been increasingly used in several application fields for many purposes involving a high number of human activities. Unfortunately, in addition to this, the number of cyber-attacks related to mobile platforms is increasing day-by-day. However, although advances in Artificial Intelligence science have allowed addressing many aspects of the problem, malware classification tasks are still challenging. For this reason, the following paper aims to propose new special features, called permission maps (Perm-Maps), which combine information related to the Android permissions and their corresponding severity levels. Such features have proven to be very effective in classifying different malware families through the usage of a convolutional neural network. Also, the advantages introduced by the Perm-Maps have been enhanced by a training process based on a federated logic. Experimental results show that the proposed approach achieves up to a 3% improvement in average accuracy with respect to J48 trees and Naive Bayes classifier, and up to 16% compared to multi-layer perceptron classifier. Furthermore, the combined use of Perm-Maps and federated logic allows dealing with unbalanced training datasets with low computational efforts.
Adiposity, diabetes, lifestyle factors and risk of gastroesophageal reflux disease: a Mendelian randomization study
Authors: Yuan Shuai , Larsson Susanna C. 
Published: February 2022

AbstractAdiposity, diabetes, and lifestyle factors are linked to gastroesophageal reflux disease (GERD) in observational studies. We conducted a two-sample Mendelian randomization analysis to determine whether those associations are causal. Independent genetic variants associated with body mass index (BMI), waist circumference (with and without adjustment for BMI), type 2 diabetes, smoking, and alcohol, coffee and caffeine consumption at the genome-wide significance level were selected as instrumental variables. Summary-level data for GERD were available from a genome-wide association meta-analysis of 71,522 GERD cases and 261,079 controls of European descent from the UK Biobank and QSkin Sun and Health studies. The odds ratio (OR) of GERD was 1.49 (95% confidence interval (CI), 1.40–1.60) for one standard deviation (SD) increase in BMI, 1.07 (95% CI, 1.04–1.10) for one-unit increase in log-transformed OR of type 2 diabetes, and 1.41 (95% CI, 1.31–1.52) for one SD increase in prevalence of smoking initiation. There were suggestive associations with GERD for higher genetically predicted waist circumference (OR per one SD increase, 1.14, 95% CI, 1.02–1.26) and caffeine consumption (OR per 80 mg increase, 1.08, 95% CI, 1.02–1.15). Genetically predicted waist circumference adjusted for BMI, alcohol or coffee consumption was not associated GERD. This study suggests causal roles of adiposity, diabetes, and smoking, and a possible role of high caffeine consumption in the development of GERD.
Mastering humanitarianism? A survey of postgraduate humanitarian courses
Authors: Stibral Adriana A. , Zadeh-Cummings Nazanin , Clarke Matthew 
Published: February 2022

AbstractHumanitarian events are increasing globally, both in number and intensity. In response, the international community spends approximately US$30 billion annually to alleviate both the immediate consequences of these climatic, geographic, and human-induced events but also to support mitigation and recovery. Over the past two decades, the humanitarian sector has increasingly professionalised. One under-studied aspect of this professionalisation is an increase in postgraduate studies in humanitarian action over the last 20 years. Despite this increase, there is no agreement on core curriculum or pedagogy across humanitarian studies courses. How do current Masters of Humanitarian Assistance (MHA) offerings converge and differ, and how can such courses further their contribution to the humanitarian endeavour? This paper surveys 26 anglophone courses offered in the United States, Europe, the United Kingdom, Australia, India, and Nigeria, exploring key characteristics of course entry requirements, flexibility, research, practical components, and academic foci. It does not recommend what a core curriculum for humanitarian courses should be, but does argue that core curriculum for humanitarian courses should be identified by relevant and diverse stakeholders such as affected communities, humanitarian agencies, disaster management bodies, and governments, to ensure that courses in this field provide appropriate learning outcomes. The paper suggests how such a ‘charter’ may be developed.
The importance of being petioled: leaf traits and resource-use strategies in Nuphar lutea
Authors: Dalla Vecchia Alice , Bolpagni Rossano 
Published: February 2022

AbstractIntraspecific trait variability (ITV) can be considerably high and reveal plant local adaptation. The aim of this study is to investigate ITV of leaf traits (including petioles) in a rooted floating-leaved macrophyte (Nuphar lutea) at the local scale. We expected to see changes in resource-use strategies in relation to water and sediment properties. 96 leaves were sampled in a hyper-eutrophic shallow lake in central Italy, together with environmental parameters. Results highlight the influence of water depth and sediments in modulating environmental conditions and thus leaf traits. Leaf area and fresh and dry weight increased with water depth, a relation that catches the construction costs of petioles. The negative relation found between specific petiole area and conductivity suggests a stress imposed by high nutrient availability which triggers unfavorable conditions for N. lutea. We demonstrated the relevance of petiole traits for a rooted macrophyte. Petiole aerenchyma or photosynthetic extra surfaces fundamentally contribute to fit the environment, opening new questions for the functional investigation of macrophytes. Excluding petioles in the assessment of leaf traits reduces the possibility to understand the ecological/adaptive processes of nympheids. New data are urgently needed to increase the number of data and species to be analyzed.
Dynamic Changes of NCR− Type 3 Innate Lymphoid Cells and Their Role in Mice with Bronchopulmonary Dysplasia
Authors: Cai Jiayu , Lu Hongyan , Su Zhaoliang , Mi Lanlan , Xu Suqing , Xue Zhengyang 
Published: February 2022

Abstract—Inflammation is one of the important pathogenesis of bronchopulmonary dysplasia (BPD). Type 3 innate lymphoid cells (ILC3) play a role in a variety of inflammatory lung diseases. In this study, we established the BPD model by injecting lipopolysaccharide into the amniotic cavity of pregnant mice. Here, we investigated the dynamic changes of ILC3 and NKP46− ILC3 population in lung tissues of mice from BPD and the control groups. Results showed that the proportion of ILC3 and NKP46−ILC3 in the BPD group was higher than those of the control group. In addition, the cytokines interleukin-17 (IL-17) and interleukin-22 (IL-22) secreted by ILC3 in this model had also changed that their expression was significantly increased compared with that of the control group. Flow cytometry demonstrated that ILC3 were a rapid source of IL-17. In the anti-CD90 knockdown experiment, we confirmed the alleviation of BPD inflammation in the absence of ILC3. In addition, we injected mice with anti-IL-17 neutralizing antibody, and the results showed that IL-17 could aggravate BPD inflammation. Taken together, ILC3 may play a pro-inflammatory role in BPD by secreting IL-17.
The AIDA and the extra laser systems for excimer laser trabeculotomy proved comparable IOP lowering efficacy—12-month results
Authors: Hommayda Sufian , Hamann Timothy , Töteberg-Harms Marc 
Published: February 2022

Abstract
Purpose
Cataract surgery combined with excimer laser trabeculotomy (phaco-ELT) leads to a significant reduction in intraocular pressure by enhancing trabecular outflow. The aim of this study is to compare two laser systems for ELT (AIDA vs. ExTra).

Methods
In this retrospective chart review, inclusion criteria were a diagnosis of glaucoma and phaco-ELT between 07/17/2010 and 07/17/2018. Data were collected preoperatively and postoperatively up to 1 year. Success was defined as IOP reduction of ≥ 20% compared to baseline plus an IOP of < 21 mmHg with no hypotony, no loss of light perception vision, and no subsequent glaucoma surgery.

Results
Three hundred and fourteen eyes (mean age 75.9 ± 8.6 years) were included. Baseline intraocular pressure (IOP) for the ExTra group (94 eyes) was 20.3 ± 5.9 mmHg on 2.0 ± 1.3 anti-glaucoma drugs (AGD) and a best-corrected visual acuity (BCVA, logMar) of 0.5 ± 0.4. For The AIDA group (220 eyes), baseline IOP was 18.7 ± 6.3 mmHg on 2.0 ± 1.3 AGD and a BCVA of 0.3 ± 0.3. In the ExTra group, IOP was reduced to 12.8 ± 2.5 mmHg (−37%) and in the AIDA group to 14.7 ± 3.9 (−21%, p = 0.14) at 1 year. AGD reduction in the ExTra group was 1.3 ± 1.5 and 1.8 ± 1.4 in the AIDA group (p = 0.14). Success rates were 80% (ExTra) and 70% (AIDA), respectively (p = 0.552). Thirty-one eyes (10.0%) required a subsequent glaucoma surgery during the follow-up.

Conclusion
Both laser platforms, the ExTra and the AIDA laser, used for Phaco-ELT lead to a significant reduction in intraocular pressure and anti-glaucoma drugs with no statistically significant difference in success rates during the follow-up of 12 months.

Trial Registration Swissethics: 2018–01,791.
Cryoballoon ablation for paroxysmal atrial fibrillation in Japan: 2-year safety and efficacy results from the Cryo AF Global Registry
Authors: Kimura Masaomi , Kobori Atsushi , Nitta Junichi , Hirao Kenzo , Shizuta Satoshi , Kurita Takashi , Okishige Kaoru , Kumagai Koichiro , Koyama Junjiro , Hiroshima Kenichi , Inaba Osamu , Goya Masahiko , Yamauchi Yasuteru , Kueffer Fred J. , Becker Daniel , Okumura Ken 
Published: February 2022

Abstract
Purpose
Catheter ablation is a recommended rhythm control therapy after failed or intolerant antiarrhythmic drug (AAD) treatment for patients with atrial fibrillation (AF). This study evaluates clinical performance and safety of pulmonary vein isolation (PVI) using the cryoballoon (Arctic Front Advance) in Japan.

Methods
Cryo AF Global Registry is a prospective, multi-center registry. Patients with paroxysmal AF (PAF) were treated at 10 Japanese hospitals. Efficacy was evaluated by freedom from a ≥ 30-s recurrence of AF/atrial flutter (AFL)/atrial tachycardia (AT), AF-related symptoms, and quality of life using the EQ-5D-3L questionnaire. The safety endpoint was serious device- and procedure-related adverse events.

Results
The study included 352 patients with PAF (65 ± 10 years of age, 36% female, 36% without prior failure of AAD). Mean duration since first diagnosis of AF was 3.0 ± 5.5 years. Serious device- and procedure-related adverse event rate was 2.6% (95% CI: 1.2–4.8%). Freedom from AF/AFL/AT was 88.5% (95% CI: 84.7–91.4%) at 12 months and 86.7% (95% CI: 81.1–90.8%) at 24 months. The number of patients with ≥ 1 AF symptom was significantly decreased from 88% at enrollment to 22% (p < 0.01) at 12-month follow-up. General quality of life using EQ-5D did not improve significantly after 12 months in the summary score. However, in the visual analog scale score, there was improvement (5.8 ± 18.4; p < 0.01).

Conclusions
This study demonstrates that cryoablation used for PVI is a safe and effective treatment in real-world use for patients with PAF in Japan.
Major land use and vegetation influences on potential pollinator communities in the High Plains of Texas
Authors: Begosh Angela , Smith Loren M. , McMurry Scott T. 
Published: February 2022

Abstract
In 2016, the annual value of all global crops dependent upon pollination was valued at $ 235–$ 577 billion (US$). Pollination service is threatened by habitat loss, pesticides, and climate change. We collected potential pollinators with blue vane traps in native grasslands, Conservation Reserve Program (CRP) lands, and cropland (land use), and their embedded playa wetlands (land type) in the Southern High Plains of Texas (SHP). We collected vegetation data that included floral cover, floral diversity, native grass cover, introduced grass cover, canopy gap, and duff cover. Our objective was to determine if individual vegetation characteristics influenced potential pollinator abundance and richness in addition to land use or land type as a whole. The top model explaining abundance was land use, land type, and floral cover. Floral cover had a positive influence on all land uses. The top model that explained insect richness was land use x floral cover, land type, canopy gap, and duff cover. Floral cover positively influenced insect richness in native grasslands but negatively influenced cropland and CRP richness. Percent of canopy gap had a slight negative influence on insect richness, and duff cover positively influenced richness. Our recommendations to land managers are to protect playas to preserve undisturbed areas and native floral resources and seed all future CRP contracts with floral rich plantings to provide for pollinators over the entire growing season.

Implications for insect conservation
Our results show that vegetation characteristics shared by all land uses such as floral cover, canopy gap and duff cover influence pollinator abundance and richness. Therefore, conserving playa wetlands and programs such as the CRP have the potential for enhancing pollinator habitat in working landscapes of the SHP of Texas.