bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model Selection for Survival Individualized Treatment Rules Using the Jackknife Estimator
Authors: Honvoh Gilson , Cho Hunyong , Kosorok Michael 
Published: June 2022

Abstract
Background: Precision medicine is an emerging field that involves the selection of treatments based onpatients’ individual prognostic data. It is formalized through the identification of individualized treatment rules(ITRs) that maximize a clinical outcome. When the type of outcome is time-to-event, the correct handling ofcensoring is crucial for estimating reliable optimal ITRs. Methods: We propose a jackknife estimator of the value function to allow for right-censored data for a binarytreatment. The jackknife estimator or leave-one-out-cross-validation approach can be used to estimate thevalue function and select optimal ITRs using existing machine learning methods. We address the issue ofcensoring in survival data by introducing an inverse probability of censoring weighted (IPCW) adjustment inthe expression of the jackknife estimator of the value function. In this paper, we estimate the optimal ITR byusing random survival forest (RSF) and Cox proportional hazards model (COX). We use a Z-test to comparethe optimal ITRs learned by RSF and COX with the zero-order model (or one-size-fits-all). Through simulationstudies, we investigate the asymptotic properties and the performance of our proposed estimator underdifferent censoring rates. We illustrate our proposed method on a phase III clinical trial of non-small cell lung cancer data. Results: Our simulations show that COX outperforms RSF for small sample sizes. As sample sizes increase,the performance of RSF improves, in particular when the underlying distribution of the failure times follows anon-linear pattern. The estimator is fairly normally distributed across different combinations of simulationscenarios and censoring rates. When applied to a non-small-cell lung cancer data set, our method determinesthe zero-order model (ZOM) as the best performing model. This finding highlights the possibility that tailoringmay not be needed for this cancer data set. Conclusion: The jackknife approach for estimating the value function in the presence of right-censored datashows satisfactory performance when there is small to moderate censoring. Winsorizing the upper and lowerpercentiles of the estimated survival weights for computing the IPCWs stabilizes the estimator.
Spectroscopic and chemical properties of biochar and water treatment residual nanoparticles and their effects on canola growth and biological activity
Authors: El-shahawy Asmaa , Ibrahim Mahmoud , AbdEl-Halim AbdEl-Halim , Talha Naser , Mahmoud Esawy 
Published: June 2022

Abstract
Nanotechnology is a promising science in the development and improvement of soil, raising its production capacity and recycling waste in a hastily manner. This study aims to investigate the properties of some recycled nanomaterials and their effect on the biological activity and productivity of canola in degraded soils. Measuring the spectroscopic and chemical properties of nanomaterials such as biochar (nB) and water treatment residuals (nWTR) and adding them at different rates to the degraded soil. The results showed that the FTIR and XRD spectra of nWTR and nB contain many functional groups (such as C = O, OH, C = C, C-H, Si-O-Al, and Si-O-Si) and minerals. Zeta potential of the nB and nWTR was − 31.08 mV and − 65.25 mV, respectively. Addition of nB or nWTR at different rates significantly improved canola yield. Seed weight of canola plant increased with increasing nB rate by more than 64%, while it decreased with increasing nWTR rate. Microbial biomass carbon (MBC) and the activity of dehydrogenase (DHA) and catalase (CLA) increased significantly in the treated pots with the addition of nB and nWTR at different rates. Our results suggested the possibility of adding reused materials in the form of nanomaterials to the degraded soils, which would have the ability to improve their properties and increase their yield.
A sutible model for drying kenitic of wood fiber using halogen moistuer analayzer
Authors: Arabi Mohammad ,   Mohammad Dahmardeh qalehno1
Published: June 2022

Abstract

Drying wood fiber is a complex, dynamic, highly nonlinear, and energy-intensive process involving simultaneous heat and mass transfer. So, the theoretical modeling of wood fiber drying because wood fiber shrinks anisotropically during a drying process is very complicated. The semi-theoretical and empirical thin-layer drying models developed on a laboratory scale are a suitable option for examining the drying kinetics of lignocellulose materials. In this study, drying kinetics of wood fibers were evaluated using 18 semi-empirical models at three temperatures of 105°C, 120°C, and 135°C, utilizing a halogen moisture analyzer. The findings revealed that raising the temperature increased the drying constant while decreasing the drying time of wood fibers. According to drying curves, no constant drying rate was observed and all the drying process occurred in two falling drying rate periods. More specifically, despite the high initial moisture content of wood fiber about 170% (based on dry weight), the wood fiber drying process was mainly controlled by diffusion mechanism. The fitness of drying curves on semi-theoretical and empirical models based on statistical parameters, including root mean square error (RMSE), sum of square errors (SSE), and coefficient of determination (R2) showed that the Midilli et al. model had the highest coefficient of determination and the lowest error percentage. Also, the moisture content was more accurately predicted by ANN model than the Midilli et al. model.
mRNA-miRNA bipartite network analysis in order to repurpose novel drugs in male infertility
Authors: Samadi Sina , Ghalandari Zahra , MotieGhader Habib , Tabrizi-Nezhadi Parinaz , Nabi Mahsa Najjari , Bagheri Dena Mohammad , Maleki Masoud , Yari Amir Hossein , Nematzadeh Sajjad , Torkamanian-Afshar Mahsa , Kiani Farzad 
Published: June 2022

Abstract
Background: In the current generation, infertility is one of the leading reasons for relationship problems. Infertility is defined as having active intercourse without the use of birth control pills on a yearly basis not resulting in zygote development and fertilization. Methods: In the current study, genes associated to male infertility were collected, and then a PPI network was reconstructed. Next, four protein modules were discovered from the reconstructed PPI network. Afterwards, for every protein module a mRNA-miRNA interaction sub-network was drawn. Finally, based on the degree and importance of these genes, modules were introduced as the main markers of male infertility, followed by naming some drugs involved in the disease.Results: Based on PPI network analysis, five genes including TP53, ESR1, PIK3CA, BRAF, and HIF1A are introduced as key candidates in male infertility disorder. Further, hsa-miR-92a-3p, hsa-miR-16-5p, hsa-miR-21-5p, hsa-miR-335-5p, and hsa-miR-106b-5p are probably highlighted among miRNAs. Finally, a drug-gene interaction network was remade for male infertility, and CISPLATIN, DOXORUBICIN, FLUOROURACIL, DOCETAXEL, and PACLITAXEL were found to be the most potent chemotherapy drugs in inducing the illness. Conclusions: According to the findings, it is recommended that young couples, who are having chemotherapy and children, use lower risk treatments rather than the listed medicines as much as possible in their treatment. Given that the steps were computational, it is suggested that these genes and miRNAs be realistically investigated in the laboratory in future research, and it is preferable to offer alternative low-risk medicines in other studies.
Dual-specificity phosphatase 19 alleviates cardiac hypertrophy via inhibiting ASK1 phosphorylation
Authors: Li Ya , Lu Jia , Liu Jing , Liu Baoshan , Zhang Aiyuan , Zuo Caojian , Liu Bei 
Published: June 2022

Abstract
Dual-specificity phosphatase 19 (DUSP19) negatively regulates MAPK pathway and has become a promising target for treating spinal cord injury and osteoarthritis. However, the function and underlying mechanism of DUSP19 in cardiac hypertrophy remain unclear. Our study observed that DUSP19 was significantly upregulated in cardiomyocytes stimulated with angiotensin-II and hypertrophic hearts. In vitro, knockdown of DUSP19 significantly aggravated cardiomyocytes hypertrophy induced by angiotensin-II, whereas DUSP19 overexpression ameliorated hypertrophy. In vivo, overexpression of DUSP19 using AAV9 gene-transfer attenuated cardiac hypertrophy, fibrosis, ventricular dilation and dysfunction induced by pressure overload. Mechanistically, DUSP19 overexpression blocked the phosphorylation of ASK1 and its downstream pathway (JNK and p38), whereas knockdown of DUSP19 activated the ASK1/p38-JNK pathway. Moreover, we found that DUSP19 directly bound to ASK1. In addition, ASK1 inhibitor reversed the exaggerated cardiomyocytes hypertrophy induced by DUSP19 knockdown. This study suggested that DUSP19 negatively regulate cardiac hypertrophy induced by pressure overload through inactivation of ASK1/p38-JNK and may provide new therapeutic target for myocardial hypertrophy.
Assessing Component Orientation of Total Hip Arthroplasty using the EOS Imaging System
Authors: Ma Zhuyi , Tang Hao , Zhou Yixin , Wang Siyuan , Yang Dejin , Guo Shaoyi 
Published: June 2022

Abstract
Background: Three-dimensional computed tomography (3D CT) reconstruction is the reference standard for measuring component orientation. However, functional cup orientation in standing position is preferable compared to supine CT scans. The EOS imaging system can analyze standing hip component orientation with low-dose radiation. We aimed to assess validity and reliability of the component orientation using the EOS imaging system compared to the 3D CT reconstruction, and explore the differences between the functional cup orientation in standing images and supine CT scans.Methods: A retrospective study, including 44 patients (50 hips) of total hip arthroplasty, was conducted. CT scans were taken 1 week after surgery and EOS images were taken in the follow-up 6 weeks later. Component orientation measurement was performed using the anterior pelvic plane and the radiographic coronal plane as reference, respectively.Results: The study showed no significant difference between cup anteversion (p = 0.160), cup inclination (p=0.486), and stem anteversion (p=0.219) as measured by the EOS imaging system and 3D reconstruction. The differences calculated by the Bland–Altman analysis ranged between -0.4° to 0.6° for the three measured angles. However, there was an average difference of 4.39 between functional anteversion (p=0.035) and functional inclination (p=0.030), as measured in standing images and supine 3D CT scans. Conclusions: Measurement of the EOS imaging system is reliable and accurate as compared with 3D CT reconstruction. Standing view orthogonal radiographies of the hip are required and preferable for evaluating the functional component orientation, which is significantly different from the supine CT measurement.
Composition Characterization of Ulva Ohnoi Cultivated in a Biofloc System
Authors: Rocha Jamilly Sousa , Santos Daniele , Candia Efrayn Wilker de Souza Candia de Souza , Hayashi Leila , Bauer Claúdia Marlene , Maraschin Marcelo , Vieira Felipe do Nascimento 
Published: June 2022

Abstract
This work evaluated the cultivation of the macroalgae Ulva ohnoi on the performance of algal biomass and changes in its proximate and biochemical composition after cultivation in a biofloc system. U. ohnoi was cultivated in three experimental units with aeration, heating, initial density of 6 g L-1 for 28 days. The water used for cultivation was collected from a biofloc matrix tank and exchanged 90% once a day throughout the experiment. Temperature, salinity and illuminance were measured twice a day. To evaluate the growth of the macroalgae, weekly weighing was performed, and the daily growth rate was calculated. The density of each experimental unit was weekly adjusted to the initial density (6 g L-1), and the remain was saved for the composition analyses. Results showed an average plant growth of 1.15% day-1, totaling 49.5 g of weekly biomass increase. A significant difference was observed when comparing the initial 2.64±0.3% and final 4.62±0.2% ulvan concentration, and an increase of 30.2% in protein concentration at the end of the cultivation. No statistical differences were found regarding the concentration of phenolic compounds and chlorophylls (a and b) during the weeks. An increase in flavonoid concentration was observed on days 7 and 14 (0.41±0.04; and 0.41±0.07 µg g-1 of dry weight), as well as a decrease in carotenoid concentration of approximately 41.3 %. In conclusion, an increase in protein and ulvan concentrations were observed after the macroalgae U. ohnoi was cultivated in the biofloc system.
The predictive role of spring season Atlantic Meridional Mode (AMM) in Indian Summer Monsoon Rainfall (ISMR) variability during the recent decades
Authors: Pillai Prasanth A , Dhakate Ashish R , Ramu D. A , G Kiran V. 
Published: June 2022

Abstract
The present study shows that the weak and out-of-phase relationship between the boreal spring Atlantic Meridional Mode (AMM) index and ISMR during the 1990–2002 period turned significant and positive after that. During the first period, the positive phase of AMM was co-occurring with the El Nino years and resulted in stronger cold SST anomalies in the south equatorial Atlantic during summer. This pattern is associated with decreased convection in the south Atlantic extending to the western Indian Ocean and India. During the period of positive AMM-ISMR relationship, the warm SST anomalies in the northern Atlantic region are strengthened and the resultant circulation is instrumental for increased convection over India. During the second period, the ENSO-induced anomalies over the tropical Atlantic also strengthen the anomalies in the northern flank of AMM. The major mode of the summer season Atlantic Ocean SST (EOF1) is dominated by ENSO induced pattern during the first period, while the AMM spring mode continued to summer resulting in stronger teleconnection after 2002. Many of the seasonal prediction models that participated in the NMME project capture the phase reversal of AMM-ISMR correlation when initialized during February. The models with a weak AMM-ISMR relationship in the recent period also have feeble AMM-ENSO association, resulting in weak North Atlantic SST anomalies associated with AMM. The study indicates that the spring season AMM index can provide a predictive signal for ISMR in seasonal prediction models, but they need to simulate proper interactions of the tropical Atlantic and Pacific Oceans.
Synthesis and characterization of crystalline Nano silica from rice husk (agricultural waste) and its magnetic composites
Authors: Hussain Sajid , Singh Rakesh Kumar , Kumar Singh Sonu , Kumar Nishant , Kumar Gaurav 
Published: June 2022

Abstract
A cost-effective and environmentally friendly technology was used to make crystalline Nano silica (SiO2) from rice husk. Crystalline Amos Nano silica, ferrites, and PVDF were used to make a magnetic nanocomposite utilising injection moulding technology. The crystalline form of silica is revealed via XRD pattern analysis. SEM studies revealed that the particle size of SiO2 was extremely tiny, implying that crystalline Nano silica was formed from the rice husk. The absorption peaks of the Si–Oi–Si (silanol) functional group are seen in FTIR spectra. The UV-Spectrometer reveals higher absorption of SiO2 in UV region which suggest it uses as catalytic booster while lower absorption in the visible region is seen. Direct and indirect band gap of the sample is obtained using Tauc plot. Magnetic measurement shows nano silica is diamagnetic. Due to the presence of ferrite in the nanocomposite, the crystalline Nano silica-Ferrite-PVDF nanocomposite is ferromagnetic and is also revealed by hysteresis loop. Nanocomposite's magnetic hysteresis loop demonstrates that the materials can be employed as polymer magnets derived from natural source. In this paper, the physical characteristics of crystalline Nano silica and its composites with PVDF and ferrite are investigated. The findings of this study could aid in the utilisation of Nano silica materials that have been developed in various technological applications.
The use of different LEDs wavelength and light intensities on in vitro proliferation of cherry rootstock: influence on photosynthetic pigments, photosystem II photochemistry and leaf anatomy
Authors: Sarropoulou Virginia , Sperdouli Ilektra , Adamakis Ioannis-Dimosthenis , Grigoriadou Katerina 
Published: June 2022

Abstract
Plant growth and development are strongly influenced by light quality conditions in their environment. In this study, shoot proliferation, photosynthetic pigments, leaf anatomy and photosystem II photochemistry of Gisela 6 cherry rootstock (Prunus cerasus x Prunus canescens) were investigated. Initially, three light wavelength absorption spectra including 400–700 nm (mainly blue-green, White Fluorescent Light, WFL), 450–550 nm (mainly blue-red: BR, LED2) and 450–660 nm (blue-green-yellow-orange-red, LED3) under 40 µmol m− 2 s− 1 intensity were studied. Following that, three Light Emitting Diodes (LED) intensities including 20 (LED1), 40 (LED2), and 120 µmol m− 2 s− 1 (LED4) were investigated under BR spectrum. The culture medium used was the MS (Murashige and Skoog) containing 4.4 µΜ 6-benzyladenine (BA), 0.05 µΜ α-naphthalene acetic acid (NAA) and 0.3 µM gibberellic acid (GA3) (30 days, 16h photoperiod, 22 ± 2 oC). WFL exhibited non-significant differences with LED2 (shoot number 4.25, proliferation rate 4.30, shoot height 0.91 cm). LED2 displayed higher fresh and dry shoot biomass, better PSII functionality, increased Chl a/b, Chl b and carotenoids content, avoiding oxidative damage as evidenced by the decreased stressed explants (5.36%). Leaf anatomy under LED2 and WFL was similar. LED4 presented the highest rate of stressed explants, with their leaf anatomy being severely affected, as leaves had a reduced mesophyll cell density. In LED4, the proportion of the absorbed energy used in photochemistry (ΦPSII) was decreased whereas the increased quantum yield of non-regulated energy loss in PSII (ΦNO) could not be compensated by the increased photoprotective energy dissipation (ΦNPQ). Therefore, LED2 was the most beneficial for growing Gisela 6 plantlets in vitro.
Association between career adaptability and turnover intention: the mediating role of psychological capital
Authors: Sun Changxian , Xing Yurong , Wen Yuting , Wan Xia , Ding Yaping , Cui Yan , Xu Wenhui , Wang Xiaoxiao , Xia Hongling , Zhang Qian 
Published: June 2022

Abstract
Background
High turnover intention of nursing assistants was detrimental to the sustainability of long-term care. Career adaptability is an important determinant in reducing turnover intention, but little research has explored the mechanism from the perspective of psychological capital. The aim of this study was to analyze the association between career adaptability and turnover intention and to examine the mediating role of psychological capital between career adaptability and turnover intention among nursing assistants in mainland China.
Methods
A cross-sectional online study was conducted among 276 nursing assistants from eight nursing homes in Nanjing, China. The participants’ career adaptability, psychological capital, and turnover intention were obtained. SPSS 26.0 and Amos 24.0 software were employed for statistical analysis.
Results
Career adaptability was positively related to psychological capital and negatively linked to turnover intention (P༜0.01). Psychological capital played a fully mediating role (β=-0.085, P༜0.05) in the relationship between career adaptability and turnover intention, and the largest indirect effect was generated through the curiosity dimension.
Conclusions
The management of long-term care facilities should focus on assessing the level of career adaptability of nursing assistants. The overall improvement of career adaptability and psychological capital is conducive in reducing turnover intention. Targeted interventions are recommended to improve career adaptability and reduce turnover intentions by increasing career curiosity. Online career adaptability programs can be developed for nursing assistant students to improve their psychological capital and facilitate career transitions.
Influence of sexual mindsets on Brazilian marital quality and life satisfaction
Authors: Rocha Fabricio de Andrade , Wagner Adriana 
Published: June 2022

Abstract

Studies confirm that mindsets shape behaviors in love relationships, including in sex life. This paper reports exploratory research that aimed to verify the associations between implicit theories of sex, marital quality, and life satisfaction of Brazilian people. 657 adults living with a romantic partner for at least 6 months filled an online survey and data were analyzed through linear regressions and moderation analysis. Results showed that high levels of sexual destiny belief are associated with lower marital quality, lower life satisfaction, and higher divorce wish. High levels of sexual growth belief were associated with higher marital quality, higher life satisfaction, but surprisingly don’t predict lower divorce wish. We also found that sexual growth belief moderates the association between sexual destiny belief and marital quality, which suggests that it may act as a protective factor for marriage. These results indicate that interventions to promote marital quality by encouraging effort and hard work in relationships may produce positive outcomes.
Renal cell carcinoma with atypical metastases sites revealed by diabetes mellitus: a case report
Authors: Jelleli Nejmeddine , Loghmari Ahmed , Belkacem Oussama , Tlili Ghassen , Jellali Bilel , Chouaya Sabrine , Bouassida Kaireddine , Hmida Wissem Ben , Jaidane Mehdi , Hmissa Sihem 
Published: June 2022

Abstract
Background : Metastatic renal cancer represents 13.3% of all kidney cancers. Lung, bone, lymph nodes and liver are the most common metastatic sites. Incidental discovery of renal tumor disease interests 36% of patients with stage IV. This observation presents a particular circumstance of renal tumor discovery and unusual metastatic sites.Case presentation : We report the case of a 64-year-old woman recently diagnosed with diabetes mellitus. An uro-CT scan had shown a polymetastatic left renal tumor with unusual metastatic sites: parietal pleura, pancreas, and contralateral kidney. The patient underwent a biopsy of the thoracic parietal nodule. The pathology report concluded to the diagnosis of a pleural metastasis from a clear cell renal cell carcinoma (ccRCC). She had a targeted therapy. At the last follow-up dating from 3 months after admission, the patient had altered general condition associated with total hematuria.Conclusions : Parietal pleura, pancreas, and contralateral kidney are rare secondary sites of RCC. The clinical expression of metastatic invasion of the pancreas can rarely fit with diabetes. Metastatic dissemination to these organs is most often associated with an unfavorable prognosis.