bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid degeneration of iPSC-derived motor neurons lacking Gdap1 engages a mitochondrial-sustained innate immune response
Authors: Torres Josema , Leon Marian , Prieto Javier , Navarro Maria Micaela Molina , Garcia Francisco , Barneo-Muñoz Manuela , Ponsoda Xavier , Saez Rosana , Palau Francesc , Dopazo Joaquin , Belmonte Juan Carlos Izpisua 
Published: November 2022

Abstract
Charcot-Marie-Tooth disease is a chronic hereditary motor and sensory polyneuropathy targeting Schwann cells and/or motor neurons. Its multifactorial and polygenic origin portrays a complex clinical phenotype of the disease with a wide range of genetic inheritance patterns. The disease-associated gene GDAP1 encodes for a mitochondrial outer membrane protein. Mouse and insect models with mutations in Gdap1 have reproduced several traits of the human disease. However, the precise function in the cell types affected by the disease remains unknown. Here, we use induced-pluripotent stem cells derived from a Gdap1 knockout mouse model to better understand the molecular and cellular phenotypes of the disease caused by the loss-of-function of this gene. Gdap1-null motor neurons display a fragile cell phenotype prone to early degeneration showing 1) altered mitochondrial morphology, with an increase in the fragmentation of these organelles, 2) activation of autophagy and mitophagy, 3) abnormal metabolism, characterized by a downregulation of Hexokinase 2 and ATP5b proteins 4) increased reactive oxygen species and elevated mitochondrial membrane potential, and 5) increased innate immune response and p38 MAP kinase activation. Our data reveals the existence of an underlying Redox-inflammatory axis fueled by altered mitochondrial metabolism in the absence of Gdap1. As this biochemical axis encompasses a wide variety of druggable targets, our results may have implications for developing therapies using combinatorial pharmacological approaches and improving therefore human welfare.
Better to be the head of a dog or the tail of a lion? Revisiting the double-edged sword model of college students' perceived overqualification
Authors: Pan Runsheng , Hou Zhijin , Wang Danni , Liu Beibei 
Published: November 2022

Abstract
School psychologists are always concerned about underperforming students; however, a recent study calls attention to a group of college students who believe themselves to outperform other students while also worrying about their futures: students who perceive themselves to be overqualified (POQ) (Wang et al., 2022). In this study, we revisited the double-edged sword model of college students’ POQ by untangling the mediating mechanism between POQ, learning engagement, and the life satisfaction of college seniors. Two questionnaire surveys were conducted and attained somewhat different results from previous studies: 1. POQ positively predicted learning engagement via the mediation of career aspiration and performance-approach goals, but not performance-avoidance goals; 2. The positive effects of POQ on career aspirations, performance-approach goals, and learning engagement were weakened by a growth mindset; 3. The relationship between POQ and life satisfaction was nonsignificant, relative deprivation negatively mediated this relationship while general self-efficacy positively mediated this relationship. These findings enriched our understanding of how POQ affect college students’ learning and living and provided evidence that growth mindset is less beneficial for members of advantaged groups in academic settings. Based on our findings, we offered practical suggestions regarding POQ students in colleges.
Posttraumatic growth in child sexual abuse survivors: a scoping review protocol
Authors: Sicilia Laura , Águila-Otero Alba , Barrios Maite , Pereda Noemí 
Published: November 2022

Abstract
Background: Child sexual abuse (CSA) is a severe type of victimization that implies prolonged and devastating traumatization. However, some research suggests that CSA survivors can also experience personal and deep transformation in the aftermath of struggling with the pain and distress derived from the abuse experience, referred to as posttraumatic growth (PTG). This change in terms of beliefs, attitudes and values is self-perceived and improves subjective well-being. The aim of this scoping review is to compile studies about PTG experienced by CSA survivors, offering a wide overview of the main methodologies and findings, and identifying areas for further research on this topic. Method: The review will follow the PRISMA guidelines for Scoping Reviews (PRISMA-ScR) and the five-step process described by Arksey and O’Malley. The databases selected for the search were: Web of Science, Scopus, PsycInfo, Medline and ProQuest Social Science. Only peer-review studies will be considered for this review, covering qualitative and quantitative methodologies. Studies about PTG in adult CSA survivors will be included in the review. Screening of the studies will be performed independently by two researchers, reading titles and abstracts from all potentially relevant studies. Any possible conflict will be resolved by a third reviewer before the full-text review. After that, two reviewers will complete the data extraction with a tailored data extraction tool. Descriptive and narrative analysis will be performed to show the results of the scoping review.
Discussion: Ethical approval is not required. The results will be disseminated through a peer-reviewed article and conference presentations.
A cross-sectional study of the relationship between the prevalence of thyroid nodules and iodine nutrition and its influencing factors based on a large sample in coastal areas
Authors: Wang Lijin , Wu Jiani , Wang Muhua , Wu Xiaoyan , Lan Ying , He Meng , Chen Diqun , Chen Zhihui 
Published: November 2022

AbstractBackground The prevalence of thyroid nodules has been increasing in recent years. Nevertheless, studies on the association between iodine status and thyroid nodules are controversial. Objective We aimed to investigate whether there is an association between iodine status and thyroid nodule disease and explore the risk factors of thyroid nodules. Methods 3926 residents participated in the investigation from the four different regions in Fujian Province in 2017, which are coastal urban area (CUA), non-coastal urban area (Non-CUA); coastal rural area (CRA), and non-coastal rural area (Non-CRA). Participants were interviewed face-to-face using a structured questionnaire. B-ultrasound was carried out to detect thyroid nodules, and drinking water, table salt, and urine samples were collected from the household. Results The iodine status was appropriate in Fujian Province. The prevalence of thyroid nodules was 22.4% in 2017, of which males accounted for 16.3% while females accounted for 28.2%. In our study, there was no statistically significant between iodine status and thyroid nodules (P > 0.05). However, female (OR = 1.9), increasing age (OR = 1.1), housewife (OR = 1.4); student (OR = 4.2); employee of enterprises and institutions (OR = 1.5), less frequency of milk and dairy products intake (< 3 times (3t) per week: 1-2t OR = 2.7; <1t OR = 2.3), and less frequency of vegetables and fruits consumption intake (< 3 times (3t) per week: 1-2t OR = 1.4; <1t OR = 1.4) are risk factors for thyroid nodule disease (P < 0.05). Conclusions There was no evidence indicating that drinking water, iodized salt, iodine-rich food, goitrogenic food, and urinary iodine concentration (UIC) are connected with thyroid nodules. Females, increasing age,, vocation (student, housewife, employee of enterprises and institutions), less frequency of milk and dairy products intake (< 3t per week), less frequency of vegetables and fruits consumption intake, and living in coastal city (coastal or urban) can increase the risk of thyroid nodules.
Ultrathin Descemet Stripping Automated Endothelial Keratoplasty (UT-DSAEK) versus Descemet Membrane Endothelial Keratoplasty (DMEK) - A Systematic Review &amp; Meta-Analysis
Authors: Hurley Daire , Murtagh Patrick , guerin marc 
Published: November 2022

Abstract

Background/Objectives:Endothelial keratoplasty (EK) is a commonly performed transplant procedure used in the treatment of corneal endothelial dysfunction. The aim of this systematic review and meta-analysis is to evaluate the differences in visual acuity outcomes, endothelial cell density (ECD) and complications between two forms of EK, ultrathin descemet stripping automated endothelial keratoplasty (UT-DSAEK) and descemet membrane endothelial keratoplasty (DMEK).Methods:A comprehensive literature search was conducted to identify studies reporting comparative results of UT-DSAEK versus DMEK. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was used for search strategy. Of 141 titles, 7 studies met the inclusion criteria; best corrected visual acuity (BCVA) (LogMAR), ECD (cells/mm2), and complications were compared, with all statistical analysis performed using Review Manager.Results:A total of 362 eyes were included for analysis. DMEK resulted in significantly better BCVA at 3 months (0.13 vs 0.23, p = 0.003) and 1 year post-op (0.10 vs 0.19, p = 0.0005). UT-DSAEK resulted in significantly lower total complications (25.2% vs 57.3%, p = 0.0001) and rates of re-bubbling (11.0% vs 33.7%, p = 0.004). No differences were found in ECD between the two procedures (1,673.8 vs 1,705.3, p = 0.77).Conclusions:DMEK results in superior visual acuity rates with quicker recovery. However, UT-DSAEK has a more favourable complication profile, particularly regarding lower rates of re-bubbling. Both are valuable options in the treatment of corneal endothelial disease and choice of procedure may depend on surgical expertise.
Preoperative predictors for return to physical activity following anterior cruciate ligament reconstruction (ACLR): a systematic review
Authors: Carter Hayley M. , Lewis Gwyn N. , Smith Benjamin E. 
Published: November 2022

Abstract
Background

Rates of return to physical activity after anterior cruciate ligament reconstruction surgery are sub-optimal. Optimising presurgical treatment may improve return rates. The purpose of this systematic review was to identify modifiable preoperative predictors for return to physical activity after anterior cruciate ligament reconstruction.

methods

Six electronic databases ( CINAHL, AMED, MEDLINE, SPORTDiscus and PsycINFO via EBSCOhost and Web of Science) were searched from inception to 31 December 2021.
The population of focus was adults aged 18–65 who had undergone primary anterior cruciate ligament reconstruction. Studies needed to identify at least one potential modifiable preoperative predictor variable and the relationship between the predictor(s) and return to physical activity. All time-points of assessment and study designs were included.
Data extraction was completed by one reviewer and verified by a second reviewer. Two reviewers completed the risk of bias assessment using the Quality in Prognostic Studies tool and Grading of Recommendations Assessment, Development and Evaluation system.

Results

The search identified 345 studies, eight met the inclusion criteria. Five studies scored 'high’, and three studies scored ‘moderate’ risk-of-bias. All preoperative predictors were of very low-quality evidence.
Five different outcome measures were used to assess return to physical activity including Tegner, Marx, Physical Activity Scale, return to play at the elite level and return to preinjury level (undefined). This was measured between 1 and 10 years post-surgery. Nine preoperative physical, six psychosocial and five demographic/clinical factors were assessed and five factors were found to be predictive. These included anterior knee laxity, quadriceps strength, psychological profile, patient estimated ability to return and graft type (patella tendon).

Conclusion

Very low-quality evidence supports preoperative physical, psychosocial and demographic/clinical factors to be predictive of return to physical activity between one- and ten-years after anterior cruciate ligament surgery.

Trial registration

This study was prospectively registered in PROSPERO: CRD 42020222567.
Effects of dietary supplementation of peanut skins (Arachis hypogaea) on performance, digestibility, and rumen fermentation of cattle: A meta-analysis
Authors: Idowu Modoluwamu , Pech-Cervantes Andres , Taiwo Godstime , Eichie F. , Ogunade Ibukun M. , Terrill Thomas H. 
Published: November 2022

Abstract
The objective of this study was to estimate the magnitude of effects of the dietary inclusion of Peanut skins (PS) byproduct (Arachis hypogea L.) on intake, total-tract digestibility, and rumen fermentation of cattle via meta-analysis. Data were collected following the PRISMA methodology. Nine manuscripts and a graduate thesis met the inclusion criteria from 1983 to 2010. The effect size was estimated by calculating the weighted raw mean differences (RMD) between PS vs. control diets. The RMD was compared with a robust variance estimation method followed by a meta-regression and a dose-response analysis fitting the diet characteristics like crude protein (CP), NDF content, ether extract content (EE), PS level in diet (0 to 40%), and tannin content as covariates. Dietary PS decreased (P < 0.01) total-tract CP digestibility (52.0 vs. 64.3%), final body weight (371.5 vs. 397.9 kg), and average daily gain (1.14 vs. 1.44 kg/d) among treatment comparisons. Likewise, PS decreased total VFA (92.6 vs. 107.6 mmol/L) and NH3N (8.22 vs. 12.1 mg/dL) among treatment comparisons, but no effects were observed on rumen pH (6.47 vs. 6.14), acetate (52.6 vs. 50.4%), propionate (31.9 vs. 33.1%), and butyrate (11.02 vs. 11.2%) molar proportions among treatment comparisons. Despite the between-cluster variance, dietary PS increased the ether extract digestibility (77.5 vs. 70.2%) among treatment comparisons. The subset and dose-response analysis revealed that PS should not exceed 8% (DM basis) in the diet to prevent negative effects on CP digestibility and animal performance. The tannin content in the diet strongly influenced the observed effects on rumen fermentation suggesting a low tolerance (> 3% in the diet) by cattle to tannins in PS. In conclusion, the results of this meta-analysis do not support the dietary inclusion of PS in cattle diets beyond 8%. However, low dietary levels of PS (up to 8%) could increase the incorporation of antioxidants and unsaturated fatty acids from PS in cattle.
Quadruplet expanded DNA (QED) genetic code for eukaryotic cells**
Authors: Singh Rama Shankar 
Published: November 2022

Abstract
QED genetic code for eukaryote cells is developed by analyzing triplet gene encoding and overcoming the lack of transcription and splicing controls. While verifying the triplet genetic code, Nobel laureate H.G. Khorana avoided synthesizing poly-rAU and poly- rCG, not promoting polypeptide formation. The QED codon is developed using these attributes. Here, the QED codon is assumed to comprise all four DNA bases (T, C, A, and G); the code is position-independent and symmetric. The adjacent bases (A: U) and (C: G) forming complementarity pairs naturally do not promote polypeptide formation; instead, they control the synthesis process, transcription, and splicing. Under these constraints, the resulting (4x4x4x4) 256 quadruplets fall into two groups: 20 independent codons encoding 20 canonical amino acids and 35 independent noncoding codons regulating the process, including transcription and splicing. Since gene variants lead to dysfunctional protein-causing diseases, steps to correct dysfunctional proteins are described, anticipating a strategy for developing cures for rare diseases and multigenic cancers.
Retrospective Audit in Documentation Practice in Surgical Inpatients Records , A Two Cycles Audit.
Authors: Gasoma ElMuhtadi B.Y. 
Published: November 2022

Abstract
Background
To provide safe and effective patient care, records must be kept in a high-quality manner. Clinical audits should be conducted on a frequent basis to ensure that high standards of record keeping are upheld. An audit and re-audit of the surgical inpatient records' documentation was conducted as part of a retrospective, descriptive study to see if it alignes with the hospital's stated policy.
AIMS / OBJECTIVES
Evaluating the hospital's present documentation process and considering how current practice could be improved were the key objectives of the audit project.
METHOD
An interactive form was created to audit the criteria using standard hospital guidelines as a foundation. Retrospective analysis of 120 case files served as the main source for the information gathered. The documentation in the records were evaluated to determine whether it were accurate and complete in every section. The data was collected, analyzed, and presented at clinical governance. We then implemented in our documentation protocol for all surgical personnel to be given instructions on the appropriate documentation and how to complete it. This data was again, prospectively collected to complete the audit cycle.
RESULTS
35 of the 37 relevant audit standards witnessed an increase in compliance. No standard or criterion's compliance dropped during the re-audit cycle. Since the first audit cycle, compliance has increased on average by 32% across all audit criteria, suggesting that some of the work done after the first cycle has had a significant effect.
DISCUSSION / CONCLUSIONS
Record-keeping must be considered as an integral part of medical practice; current documentation work demonstrates that, when performed appropriately, audit can actually affect the quality of clinical records. The audit itself can increase awareness of the need for practice improvement. The distribution of findings, instruction, training, and local action planning are all essential for developing practice.
Epidemiological and clinical characteristics of critically ill patients with Guillain-Barre syndrome in Shiraz, Iran
Authors: Naderi-Boldaji vida , Zand Farid , Asmarian Naeimehossadat , Marbooti Hoda , Masjedi Mansoor , Tabibzadeh Seyedeh Maryam , Esmaeilinezhad Zahra , Nazeri Masoume 
Published: November 2022

Abstract
Objective
This prospective study reports the epidemiological and clinical characteristics of Guillain-Barré syndrome (GBS) patients admitted to the intensive care units of Namazi Hospital, the largest referral center in the south of Iran, between March 20, 2016, to March 19, 2021.
Results
One hundred and thirty-two GBS patients were identified with an average age of 47.87 ± 15.41 years and a male/female ratio of 1.69:1. A significant proportion (49.3%) were classified as having axonal disease. The electrophysiological classification was strongly related to muscle weakness: 51.4% of patients classified as axonal had lower limb power < 3, compared with only 36% of those classified as demyelinated. This group also needed mechanical ventilation more frequently (54% vs. 46%) and for a longer duration (26 (9–37) vs. 10 (1–61) days). Pneumonia and sepsis were each observed in 16% of patients, while 12% developed a urinary tract infection. Acute Inflammatory Demyelinating Polyradiculoneuropathy (AIDP; 41.5%) was the commonest variant of GBS in our study. Six (3.8%) patients died and 126 (96.2%) survived.
Conclusion
The axonal type of disease was detected in a large portion of our critically ill GBS patients; these patients needed mechanical ventilation more frequently and for a longer duration than those in other electrophysiological study categories. Our in-hospital mortality proportion fell within the range reported in other published studies.
Enabling conservation Theories of Change
Authors: Buelow Christina , Connolly Rod , Dunic Jillian , Griffiths Laura , Holgate Briana , Lee Shing Yip , Mackey Brendan , Maxwell Paul , Pearson Ryan , Rajkaran Anusha , Sievers Michael , Sousa Ana , Tulloch Vivitskaia , Turschwell Mischa , Villarreal-Rosas Jaramar , Brown Christopher 
Published: November 2022

Abstract
Global Theories of Change (ToCs), such as the post-2020 Global Biodiversity Framework (GBF), provide broad, overarching guidance for achieving conservation goals. However, broad guidance cannot inform how conservation actions will lead to desired outcomes. We provide a framework for translating a global-scale ToC into focussed, ecosystem-specific ToCs that consider feasibility of actions, as determined by national socioeconomic and political context (i.e., enabling conditions). We demonstrate the framework using coastal wetland ecosystems as a case study. We identified six distinct multinational profiles of enabling conditions (‘enabling profiles’) for coastal wetland conservation. For countries belonging to enabling profiles with high internal capacity to enable conservation, we described plausible ToCs that involved strengthening policy and regulation. Alternatively, for enabling profiles with low internal enabling capacity, plausible ToCs typically required formalising community-led conservation. Our ‘enabling profile’ framework could be applied to other ecosystems to help operationalise the post-2020 GBF.
Hertz-rate metropolitan quantum teleportation
Authors: Zhou Qiang , Shen Si , Yuan Chenzhi , Zhang Zichang , Yu Hao , Zhang Ruiming , Yang Chuanrong , Li Hao , Wang Zhen , Wang You , Deng Guangwei , Song Haizhi , You Lixing , Fan Yunru , Guo Guangcan 
Published: November 2022

Abstract
Quantum teleportation can transfer an unknown quantum state between distant quantum nodes, which holds great promise in enabling large-scale quantum networks. To advance the full potential of quantum teleportation, quantum states must be faithfully transferred at a high rate over long distance. Despite recent impressive advances, a high-rate quantum teleportation system across metropolitan fiber networks is extremely desired. Here, we demonstrate a quantum teleportation system which transfers quantum states carried by independent photons at a rate of 7.1 ± 0.4 Hz over 64-km-long fiber channel. An average single-photon fidelity of ≥ 90.6 ± 2.6% is achieved, which exceeds the maximum fidelity of 2/3 in classical regime. Our result marks an important milestone towards quantum networks and opens the door to exploring quantum entanglement based informatic applications for the future quantum internet.
Accelerating the solar-thermal energy storage via inner-light supplying with optical waveguide
Authors: Zhang Yafang , Tang Jibin , Chen Jialin , Zhang Yuhai , Chen XiangXiang , Ding Meng , Zhou Weijia , Xu Xijin , Liu Hong , Xue Guobin 
Published: November 2022

Abstract
Solar-thermal storage with phase-change materials (PCMs) plays an important role in solar energy utilization. However, most PCMs own low thermal conductivity which restricts the thermal charging rate and leads to low solar-thermal conversion efficiency. Here, we propose to regulate the solar-thermal conversion interface in spatial dimension by transmitting the sunlight into the paraffin-graphene composite with side-glowing optical waveguide fiber. This inner-light supply mode avoids the overheating surface of the PCMs, accelerates the charging rate by 123% than that of the traditional surface irradiation mode and increases the solar thermal efficiency to ~94.85%. Additionally, the large-scale device with inner-light supply mode works efficiently outdoors, indicating the potential of this heat localization strategy in practical application.