bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating health policies with subnational disparities: a text-mining analysis of the Urban Employee Basic Medical Insurance Scheme in China
Authors: Liu Kai , Liu Wenting , He Alex Jingwei 
Published: October 2022

Abstract
Subnational disparities in most health systems often defy ‘one-size-fits-all’ approach in policy implementation. When local authorities implement a national policy in a decentralized context, they behave as a strategic policy actor in specifying the central mandates, selecting appropriate tools and setting key implementation parameters. Local policy discretion leads to diverse policy mixes across regions, thus complicating evidence-based evaluations of policy impacts. When measuring complex policy reforms, mainstream policy evaluation methodologies have tended to adopt simplified policy proxies that often disguise distinct policy choices across localities, leaving the heterogeneous effects of the same generic policy largely unknown. Using the emerging ‘text-as-data’ methodology and drawing from subnational policy documents, this study developed a novel approach to policy measurement through analysing policy big data. We applied this approach to examine the impacts of China’s Urban Employee Basic Medical Insurance (UEBMI) on individuals’ out-of-pocket (OOP) spending. We found substantial disparities in policy choices across prefectures when categorizing the UEBMI policy framework into benefit-expansion and cost-containment reforms. Overall, the UEBMI policies lowered enrollees’ OOP spending in prefectures that embraced both benefit-expansion and cost-containment reforms. In contrast, the policies produced ill effects on OOP spending of UEBMI enrollees and uninsured workers in prefectures that carried out only benefit-expansion or cost-containment reforms. The micro-level impacts of UEBMI enrolment on OOP spending were conditional on whether prefectural benefit-expansion and cost-containment reforms were undertaken in concert. Only in prefectures that promulgated both types of reforms did UEBMI enrolment reduce OOP spending. These findings contribute to a comprehensive text-mining measurement approach to locally diverse policy efforts and an integration of macro-level policy analysis and micro-level individual analysis. Contextualizing policy measurements would improve the methodological rigour of health policy evaluations. This paper concludes with implications for health policymakers in China and beyond.
Genic male and female sterility in vegetable crops
Authors: Cheng Zhihua , Song Weiyuan , Zhang Xiaolan 
Published: October 2022

Abstract
Vegetable crops are greatly appreciated for their beneficial nutritional and health components. Hybrid seeds are widely used in vegetable crops for advantages such as high yield and improved resistance, which require the participation of male (stamen) and female (pistil) reproductive organs. Male- or female-sterile plants are commonly used for production of hybrid seeds or seedless fruits in vegetables. In this review we will focus on the types of genic male sterility and factors affecting female fertility, summarize typical gene function and research progress related to reproductive organ identity and sporophyte and gametophyte development in vegetable crops [mainly tomato (Solanum lycopersicum) and cucumber (Cucumis sativus)], and discuss the research trends and application perspectives of the sterile trait in vegetable breeding and hybrid production, in order to provide a reference for fertility-related germplasm innovation.
A high-quality genome assembly of the Laotian shad (Tenualosa thibaudeaui), an endemic species of the Mekong River Basin
Authors: Wang Li , Lu Liang , Sarker Kishor Kumar , Li Chenhong 
Published: October 2022

AbstractThe Laotian shad (Tenualosa thibaudeaui) belongs to the family Clupeidae and is mainly distributed across Lao PRD, Cambodia, and northern Thailand. Due to overfishing and dam reconstruction, the Laotian shad is on the verge of extinction and currently listed as vulnerable by the IUCN. Nanopore and Illumina sequencing data were integrated to generate the first high-quality genome assembly for T. thibaudeaui. The assembled genome was 638 Mb in size, including 228 scaffolds with a N50 value of 16.6 Mb. BUSCO analysis revealed the completeness of the assembly to be more than 96%. A total of 24,810 protein-coding genes were predicted. According to the pairwise sequentially Markovian coalescent analysis, the effective population size of the Laotian shad sharply declined from 3 Mya to 20 Kya. We found a significant ratio in contraction of gene families that may reflect secondary gene loss. Our high-quality genome assembly of the Laotian shad will provide a valuable resource for future research in conservation genetics, as well as for investigating the phylogenetics and comparative genomics of shads.
Effect of the solar wind on the nature of arbitrary amplitude ion-acoustic solitary waves in Venus’ upper ionosphere
Authors: Salem S , Fayad A A , El-Shafeay N A , Sayed F S H , Shihab M , Fichtner H , Lazar M , Moslem W M 
Published: October 2022

ABSTRACT
Observations suggest that at altitudes of 1000–2000 km the interaction between the solar wind and Venus’ ionospheric plasma leads to ion-acoustic waves (IAWs) formation. For studying this hypothesis, a suitable hydrodynamic model relying on the observational data from Pioneer Venus Orbiter (PVO) and Venus Express (VEX) is developed. It consists of two ionospheric fluids of positive ions, hydrogen (H+), and oxygen (O+), and isothermal ionospheric electrons interacting with streaming solar wind protons and isothermal solar wind electrons. The favourable conditions and propagation characteristics of the fully non-linear IAWs along with their dependence on solar wind parameters are examined and compared with the available space observations. It is found that the pulse amplitude is decreased by increasing the temperature of either the solar wind protons or electrons. In contrast, a higher relative density or velocity of the solar wind protons amplifies the amplitude of the solitary structures. Moreover, only velocity variations within a certain range called the plasma velocity scale can affect the basic features of the solitary pulses. Beyond this scale, solitary waves are not affected by the solar wind protons’ velocity anymore. This theoretical model predicts the propagation of electrostatic solitary waves with a maximum electric field of 7.5 mV m−1 and a pulse time duration of 3 ms. The output of the fast Fourier transformation (FFT) power spectra of the electric field pulse is a broad-band electrostatic noise in a frequency range of ∼0.1–4 kHz. These FFT calculations are in good agreement with PVO’s observations.
Discovering Ca ii absorption lines with a neural network
Authors: Xia Iona , Ge Jian , Willis Kevin , Zhao Yinan 
Published: October 2022

ABSTRACT
Quasar absorption line analysis is critical for studying gas and dust components and their physical and chemical properties as well as the evolution and formation of galaxies in the early universe. Calcium II (Ca ii) absorbers, which are one of the dustiest absorbers and are located at lower redshifts than most other absorbers, are especially valuable when studying physical processes and conditions in recent galaxies. However, the number of known quasar Ca ii absorbers is relatively low due to the difficulty of detecting them with traditional methods. In this work, we developed an accurate and quick approach to search for Ca ii absorption lines using deep learning. In our deep learning model, a convolutional neural network, tuned using simulated data, is used for the classification task. The simulated training data are generated by inserting artificial Ca ii absorption lines into original quasar spectra from the Sloan Digital Sky Survey (SDSS), while an existing Ca ii catalogue is adopted as the test set. The resulting model achieves an accuracy of 96 per cent on the real data in the test set. Our solution runs thousands of times faster than traditional methods, taking a fraction of a second to analyse thousands of quasars, while traditional methods may take days to weeks. The trained neural network is applied to quasar spectra from SDSS’s DR7 and DR12 and discovered 399 new quasar Ca ii absorbers. In addition, we confirmed 409 known quasar Ca ii absorbers identified previously by other research groups through traditional methods.
The lure of sirens: joint distance and velocity measurements with third-generation detectors
Authors: Alfradique Viviane , Quartin Miguel , Amendola Luca , Castro Tiago , Toubiana Alexandre 
Published: October 2022

ABSTRACT
The next generation of detectors will detect gravitational waves from binary neutron stars at cosmological distances, for which around a 1000 electromagnetic follow-ups may be observed per year. So far, most work devoted to the expected cosmological impact of these standard sirens employed them only as distance indicators. Only recently their use as tracers of clustering, similar to what already proposed for supernovae, has been studied. Focusing on the expected specifications of the Einstein Telescope (ET), we forecast here the performance on cosmological parameters of future standard sirens as both distance and density indicators, with emphasis on the linear perturbation growth index and on spatial curvature. We improve upon previous studies in a number of ways: a more detailed analysis of available telescope time, the inclusion of more cosmological and nuisance parameters, the Alcock–Paczynski correction, the use of sirens also as both velocity and density tracers, and a more accurate estimation of the distance posterior. We find that the analysis of the clustering of sirens improves the constraints on H0 by 30 per cent and on Ωk0 by over an order of magnitude, with respect to their use merely as distance indicators. With 5 yr of joint ET and Rubin Observatory follow-ups we could reach precision of 0.1 km s−1 Mpc−1 in H0 and 0.02 in Ωk0 using only data in the range 0 &lt; z &lt; 0.5. We also find that the use of sirens as tracers of density, and not only velocity, yields good improvements on the growth of structure constraints.
Measuring the distortion of time with relativistic effects in large-scale structure
Authors: Sobral Blanco Daniel , Bonvin Camille 
Published: October 2022

ABSTRACT
To test the theory of gravity one needs to test, on one hand, how space and time are distorted by matter, and on the other hand, how matter moves in a distorted space–time. Current observations provide tight constraints on the motion of matter, through the so-called redshift-space distortions, but they only provide a measurement of the sum of the spatial and temporal distortions, via gravitational lensing. In this letter, we develop a method to measure the time distortion on its own. We show that the coming generation of galaxy surveys, like the Square Kilometre Array, will allow us to measure the distortion of time with an accuracy of 10–30 per cent. Such a measurement will be essential to test deviations from the ΛCDM model in a fully model-independent way. In particular, it can be used to compare the spatial and temporal distortions of space–time and to unambiguously distinguish between modifications of gravity and dark fifth forces acting on dark matter.
Temperature-dependent Small RNA Expression Depends on Wild Genetic Backgrounds of Caenorhabditis briggsae
Authors: Fusca Daniel D , Sharma Eesha , Weiss Jörg G , Claycomb Julie M , Cutter Asher D 
Published: October 2022

Abstract
Geographically distinct populations can adapt to the temperature conditions of their local environment, leading to temperature-dependent fitness differences between populations. Consistent with local adaptation, phylogeographically distinct Caenorhabditis briggsae nematodes show distinct fitness responses to temperature. The genetic mechanisms underlying local adaptation, however, remain unresolved. To investigate the potential role of small noncoding RNAs in genotype-specific responses to temperature, we quantified small RNA expression using high-throughput sequencing of C. briggsae nematodes from tropical and temperate strain genotypes reared under three temperature conditions (14 °C, 20 °C, and 30 C). Strains representing both tropical and temperate regions showed significantly lower expression of PIWI-interacting RNAs (piRNAs) at high temperatures, primarily mapping to a large ∼7 Mb long piRNA cluster on chromosome IV. We also documented decreased expression of 22G-RNAs antisense to protein-coding genes and other genomic features at high rearing temperatures for the thermally-intolerant temperate strain genotype, but not for the tropical strain genotype. Reduced 22G-RNA expression was widespread along chromosomes and among feature types, indicative of a genome-wide response. Targets of the EGO-1/CSR-1 22G-RNA pathway were most strongly impacted compared with other 22G-RNA pathways, implicating the CSR-1 Argonaute and its RNA-dependent RNA polymerase EGO-1 in the genotype-dependent modulation of C. briggsae 22G-RNAs under chronic thermal stress. Our work suggests that gene regulation via small RNAs may be an important contributor to the evolution of local adaptations.
The Value of Metagenomic Next-Generation Sequencing in Leishmaniasis Diagnosis: A Case Series and Literature Review
Authors: Han Ning , Yu Jiang , Wang Ming , Ma Yuanji , Yan Libo , Tang Hong 
Published: October 2022

Abstract

Background
Leishmaniasis is a zoonotic disease caused by Leishmania spp. and spreads through sandfly bites. Owing to the wide range of nonspecific clinical symptoms, patients with leishmaniasis are frequently misdiagnosed or underdiagnosed.

Methods
The study participants were 7 metagenomic next-generation sequencing (mNGS)–diagnosed patients with leishmaniasis who could not be diagnosed using conventional methods. Clinical data were retrospectively collected and analyzed. When searching PubMed for mNGS and leishmaniasis, 8 peer-reviewed case reports in English were retrieved.

Results
A total of 7 patients with recurrent fever, pancytopenia, and significant splenomegaly were included in this study. Only 3 individuals tested positive for rK39. Two individuals, 1 of whom was HIV-positive, had Leishmania amastigotes identified in their bone marrow. However, all patients’ blood mNGS findings pointed to Leishmania infection, and they were finally diagnosed with leishmaniasis. Sodium stibogluconate therapy with a short course of amphotericin B was administered to all patients. The prognosis for the remaining patients was good, except for 1 who died of multiple organ failure.

Conclusions
mNGS could be used to identify leishmaniasis, particularly in patients who are difficult to diagnose using conventional approaches.
The death of King Charles XII of Sweden revisited
Authors: Junno Juho-Antti , Niskanen Markku , Maijanen Heli , Niinimäki Jaakko , Junno Alina , Oura Petteri 
Published: October 2022

AbstractThe death of King Charles XII of Sweden has remained as a mystery for more than three centuries. Was he assassinated by his own men or killed by the enemy fire? Charles was killed by a projectile perforating his skull from left to right. In this study, we utilized a Synbone ballistic skull phantom and modern radiological imaging to clarify the factors behind the observed head injuries. We examined whether a musket ball fired from the enemy lines would be the most potential projectile. Our experiments with a leaden 19.5 mm musket ball demonstrated that at velocities of 200 to 250 m/s, it could cause similar type of injuries as observed in the remains of Charles . The radiological imaging supported the theory that the projectile was not a leaden but of some harder metal, as we could detect remnants of lead inside the wound channel unlike in Charles’ case. In addition, our experiments showed that a 19.5mm musket ball  produces max. 17mm hole into a felt material  . The main evidence supporting 19.5 mm projectile size has been a 19-19.5mm bullet hole in a hat that Charles was wearing during his death. Additional experiments with a 25.4 mm steel ball produced approximately 20 mm hole in the felt. As our musket ball experiments also resulted in considerably smaller cranial injuries than those in Charles’ case, we can conclude that the deadly projectile wasn’t leaden and was more than 19.5 mm in diameter, potentially an iron cartouche ball that was shot from the enemy lines.
Exploring the gender gap in welfare attitudes: relational skills and perceptions of pay equity
Authors: Hwang In Hyee , Lim Hyunji , Lee Cheol-Sung 
Published: October 2022

AbstractThis article introduces a new aspect of skill profiles, ‘relational skills’, to examine how occupation-oriented relational skills can activate different perceptions of pay equity between genders and influence support for the welfare state. Relational skills refer to the degree of which a worker possesses skills pertaining to human interactions to those regarding the operation of machines or tools. We examine how relational skill ratio differently influences perceptions of justice in the pay system for men and women and how this shapes their welfare attitudes. By analyzing levels of support for redistribution in 30 OECD member countries targeted by the International Social Survey Program in 2009, we find the gender divide in social policy preferences to be the widest in high relational skill occupations. We argue that this divide is associated with the significant contrast between men and women in whether they perceive their pay to justly reflect their efforts and skills. Our findings suggest that women’s perceptions of discriminatory wage scales and support for the welfare state will be most prominent in occupations that present evaluation ambiguities or gender ascriptions that challenge women from breaking the glass ceiling.
Early pregnancy serum levels of folate and vitamin B12 in overweight and obese women in Khartoum, Sudan
Authors: Rayis Duria A , Karar Ahmed , Alshareef Shimos A , Eltayeb Reem , Adam Ishag 
Published: October 2022

Abstract

Background
This study was conducted to assess serum levels of folate and vitamin B12 in overweight and obese pregnant women.

Methods
A cross-sectional study was conducted at Saad Abualila Hospital, Sudan. Clinical data were collected through questionnaires and body mass index (BMI) was computed from weight and height. The serum folate and vitamin B12 levels were analyzed by immunofluorescence.

Results
Of 300 enrolled women, 44.7% were of normal weight, 32.3% were overweight and 3.0% were obese. The folate level was significantly lower in overweight women (median 4.79 ng/ml [IQR 2.70‒7.70]) than in normal-weight women (median 6.650 ng/ml [IQR 3.30‒10.55]; p=0.022). There was no significant difference in the prevalence of marginal and severe folate deficiencies in women in different BMI groups. Compared with normal-weight women (median 197.5 pg/ml [IQR 150.0‒263.0]), obese women (median 173.0 pg/ml [IQR 150.0‒213.0]; p=0.038) had significantly lower vitamin B12 levels and had a higher prevalence of vitamin B12 insufficiency. Fair negative correlations (p&lt;0.01) were observed between folate and BMI (r = −0.157) and between vitamin B12 and BMI (r = −0.173).

Conclusions
Overweight and obese pregnant Sudanese women had lower levels of serum folate and vitamin B12.
Assessing the productivity of PAs and NPs
Authors: Stefos Theodore , Moran Eileen A. , Poe Stacy A. , Hooker Roderick S. 
Published: October 2022

ABSTRACT
The improvement of healthcare efficiency and productivity is of international interest. Following an expansion phase of physician associate/assistant (PA) and NPs employment, the Department of Veterans Affairs (VA) assessed how and where they were being used. Using data from 134 VA medical centers, annual productivity was examined across 30 medical and surgical specialties spanning primary care, mental health, and surgery. PA productivity differences averaged 82 relative value units per full-time employee per year more than NPs, a difference of 4%. In general, PAs were found in higher productivity ranges than NP counterparts. PAs and NPs have statistically similar productivity levels in primary care and mental health. In specialty medicine and surgery, PAs average higher annual productivity than NPs. This analysis provides some utility for managers regarding workforce composition, given the relative productivity of two types of clinicians.
Comparison of a Novel Modified All-Suture Construct versus Suspensory Suture-button Fixation in a Syndesmotic Injury Model
Authors: Baker Hayden P. , Muriuki Muturi G. , Straszewski Andrew J. , Johnson Christopher , Krishnan Pranav , Hynes Kelly , Strelzow Jason A. , Havey Robert M. , Dillman Daryl B. 
Published: October 2022

Objectives:
To biomechanically investigate a novel modified all-suture construct compared with commercially available suspensory button fixation for stabilization of the syndesmosis.

Methods:
Eight matched pairs of cadaver lower limbs were obtained. We used a material testing machine and Optotrak optoelectronic 3D motion measurement system for testing. Syndesmotic injuries were simulated, and specimens were fixed with either a suspensory suture button or modified all-suture construct. Repaired specimens were then cyclically loaded for 500 cycles. Spatial relationship of the tibia and fibula were continuously monitored for the intact, destabilized, and repaired states. The results were analyzed using independent samples t test.

Results:
There was no significant difference in sagittal or coronal plane translation between intact and either repair. Compared with the intact state, both repair techniques demonstrated significantly more external rotation of the fibula relative to the tibia and decreased construct stiffness. Cycling of the specimens did not significantly increase coronal or sagittal plane translation; however, external rotation of the fibula relative to the tibia increased and stiffness decreased with cycling for both repair techniques.

Conclusions:
Our data suggest that sagittal and coronal plane translation is no different from the intact state for both fixation techniques. However, rotation of the fibula relative to the tibia was increased, and construct stiffness was decreased compared with the intact state for both fixation techniques. These findings suggest that an all-suture construct could offer syndesmotic fixation comparable with proprietary suspensory button fixation in a cadaver model.