bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of 4‐Coordinate Ti Imido Aryloxide on the Surface of Silica for Catalytic Oxo/Imido Heterometathesis
Authors: Pichugov Andrey V. , Bushkov Nikolai S. , Rumyantsev Andrey V. , Zhizhin Anton A. , Aleshin Dmitry Y. , Strelkova Tatyana V. , Talanova Valeria N. , Takazova Rina U. , Mance Deni , Allouche Florian , Mougel Victor , Dolgushin Fedor M. , Ustynyuk Nikolai A. , Zhizhko Pavel A. , Zarubin Dmitry N. 
Published: May 2022

AbstractWe report here the synthesis of 4‐coordinate Ti imido complexes Ti(=NtBu)(OArtBu)2(py) (2) and Ti(=NtBu)(OArtBu)(Me2Pyr)(py) (3) (ArtBu=O‐2,6‐tBu2‐4‐MeC6H2, Me2Pyr=2,5‐dimethylpyrrolyl) and study their grafting onto the surface of partially dehydroxylated silica with the aim to prepare 4‐coordinate Ti imido aryloxide surface species. Study of the resulting materials with IR, solid‐state NMR, elemental and mass balance analyses demonstrates that grafting of bis‐aryloxide complex 2 leads to a predominant formation of silica‐supported Ti amide (≡SiO)Ti(NHtBu)(OArtBu)2(py) resulting from the protonation of the imido ligand with the surface silanols and only a smaller fraction of the desired imido species (≡SiO)Ti(=NtBu)(OArtBu)(py). The use of the tailored complex 3 where one of the aryloxides is replaced with a more reactive pyrrolyl ligand significantly increases the selectivity of grafting leading to the formation of the Ti imido aryloxide (≡SiO)Ti(=NtBu)(OArtBu)(py) as major surface species. The obtained materials show high activity in catalytic oxo/imido heterometathesis supporting the previously proposed hypothesis that electron‐donating environments are favorable for this transformation.
Tidal frequencies and quasiperiodic subsurface water level variations dominate redox dynamics in a salt marsh system
Authors: Grande Emilio , Arora Bhavna , Visser Ate , Montalvo Maya , Braswell Anna , Seybold Erin , Tatariw Corianne , Beheshti Kathryn , Zimmer Margaret 
Published: May 2022

AbstractSalt marshes are hotspots of nutrient processing en route to sensitive coastal environments. Whilst our understanding of these systems has improved over the years, we still have limited knowledge of the spatiotemporal variability of critical biogeochemical drivers within salt marshes. Sea‐level rise will continue to force change on salt marsh functioning, highlighting the urgency of filling this knowledge gap. Our study was conducted in a central California estuary experiencing extensive marsh drowning and relative sea‐level rise, making it a model system for such an investigation. Here we instrumented three marsh positions subjected to different degrees of tidal inundation (6.7%, 8.9%, and 11.2% of the time for the upper, middle, and lower marsh positions, respectively), providing locations with varied biogeochemical characteristics and hydrological interactions at the site. We continuously monitored redox potential (Eh) at depths of 0.1, 0.3, and 0.5 m, subsurface water levels (WL), and temperature at 0.7 m depth at each marsh position. To understand how drivers of subsurface biogeochemical processes fluctuate across tidal cycles, we used wavelet analyses to explain the interactions between Eh and WL. We found that tidal forcing significantly affects key drivers of biogeochemical processes by imparting controls on Eh variability, likely driving subsurface hydro‐biogeochemistry of the salt marsh. Wavelet coherence showed that the Eh‐WL relationship is nonlinear, and their lead–lag relationship is variable. We found that precipitation events perturb Eh at depth over timescales of hours, even though WL shows relatively minimal change during events. This work highlights the importance of high frequency in situ measurements, such as Eh, to help explain factors that govern subsurface biogeochemistry and hydrological processes in salt marshes.
Reliability and replicability in infant research: A commentary on Byers‐Heinlein et al. (2021)
Authors: Margoni Francesco 
Published: May 2022

AbstractByers‐Heinlein et al. (2021) argue that a greater focus on reliability in infant research is much needed and desirable for the field. Moreover, they offer a number of possible solutions to increase reliability in infant research. Here, I do not discuss the suitability of the offered solutions. Instead, I further develop the authors' argument by considering the worryingly downstream consequences of low reliability for the very possibility of drawing meaningful inferences from the results of replication studies. I argue that the sources of error related to sampling and measurement greatly affect the estimates, resulting in confidence intervals being often very wide. Consequently, interpreting the differences between small‐scale original and replication studies becomes a meaningless task, which, I maintain, could be replaced by a meta‐analytic mindset and the habit of fully incorporating uncertainty in the reasoning about research findings.
Strategies for high‐performance perovskite solar cells from materials, film engineering to carrier dynamics and photon management
Authors: Li Huilin , Chen Chong , Hu Hangyu , Li Yu , Shen Zhitao , Li Fumin , Liu Ying , Liu Rong , Chen Junwei , Dong Chao , Mabrouk Sally , Bobba Raja Sekhar , Baniya Abiral , Wang Mingtai , Qiao Quinn 
Published: May 2022

AbstractIn recent years, halide perovskite solar cells (HPSCs) have attracted a great attention due to their superior photoelectric performance and the low‐cost of processing their quality films. In order to commercialize HPSCs, the researchers are focusing on developing high‐performance HPSCs. Many strategies have been reported to increase the power conversion efficiency and the long‐term stability of HPSCs over the past decade. Herein, we review the latest efforts and the chemical‐physical principles for preparing high‐efficiency and long‐term stability HPSCs in particular, concentrating on the perovskite materials, technologies for perovskite films, charge transport materials and ferroelectric effect to reduce the carrier loss, and photon management via plasmonic and upconversion effects. Finally, the key issues for future researches of HPSCs are also discussed with regard to the requirements in practical application.image
Economic feasibility of subsurface drainage (SSD) to control waterlogging and soil salinity under different scenarios in the Tungabhadra project command, Karnataka, India
Authors: A V Karegoudar , J Vishwanath , R H Rajkumar , S R Anand , B S Polisgowdar , M S Ayyanagowdar , M Nemichandrapp , M J Kaledhonkar 
Published: May 2022

AbstractThe Tungabhadra irrigation command area (TBP) in Karnataka, India, has three scenarios: the head, mid and tail reach command areas. The head reach has ample good quality canal water availability, and the mid reach area has limited canal water availability. In recent decades, rice–rice monocropping in vertisols, especially by these head and mid reach farmers, has led to not only water shortages but also the development of waterlogging and secondary soil salinization in the tail (lower) reach of the command due to seepage. As the soil salinity in the head reach was less severe, a slightly wider drain spacing of 60 m was adopted over 15 ha. In the case of the mid reach, salinity was slightly higher than the head reach but slightly less than the tail reach, hence 50 m drain spacing was laid out over 24 ha. Due to the slightly higher soil salinity at the tail end of the command, a closer drain spacing of 40 m was adopted over 11 ha. In all these scenarios, the drain depth was 1.0 m. Despite differences in irrigation water availability and different soil salinity conditions, the study clearly indicated over six seasons that the SSD system is a viable solution for the reclamation of waterlogged saline soils and enhancing rice productivity in all three scenarios of the TBP command.
A novel role for aspirin in enhancing the reprogramming function of miR‐302/367 cluster and breast tumor suppression
Authors: Rezania Mohammad A. , Eghtedari Azadeh , Taha Masoumeh F. , Ardekani Ali M. , Javeri Arash 
Published: May 2022

AbstractRecent studies have provided evidence for tumor suppressive function of the embryonic stem cell‐specific miR‐302/367 cluster through induction of a reprogramming process. Aspirin has been found to induce reprogramming factors of mesenchymal‐to‐epithelial transition in breast cancer cells. Therefore, we aimed to investigate whether overexpression of miR‐302/367 cluster and aspirin treatment cooperate in the induction of reprogramming and tumor suppression in breast cancer cells. MDA‐MB‐231 and SK‐BR‐3 human breast cancer cell lines were transfected with a miR‐302/367 expressing vector and treated with aspirin. The cells were evaluated for indices of apoptosis, proliferation, migration, and invasion. In both cell lines, treatment of miR‐302/367‐transfected cells with aspirin upregulated expression of some main pluripotency factors such as OCT4, SOX2, NANOG, and KLF4, and downregulated expression of some invasion and angiogenesis markers at gene and protein levels. Aspirin increased the apoptotic rate in both cell lines transfected with miR‐302/367. Both miR‐302/367 and aspirin upregulated the expression of FOXD3 protein which is a known inducer of OCT4 and NANOG. Our results demonstrate that aspirin can enhance miR‐302/367‐induced reprogramming of breast cancer cells possibly through upregulation of FOXD3 expression. This can further augment the reversal of epithelial–mesenchymal transition and inhibits migration, invasion, and angiogenic signaling in breast cancer cells reprogrammed by miR‐302/367. Therefore, aspirin may serve as a useful adjuvant for reprogramming of cancer cells.
Hsa_circ_0003748 promotes disease progression in rheumatic valvular heart disease by sponging miR‐577
Authors: Zhang Xiaoyun , Gao Yakun , Wu Hongyu , Mao Yong 
Published: May 2022

AbstractThe diagnosis and treatment of rheumatic valvular heart disease (RVHD) require substantial improvements. Studies found that circular RNAs (circRNAs) are involved in the progression of cardiovascular diseases. We screened target hsa_circ_0003748 by circRNA microarrays uploaded to a database. We used fluorescence in situ hybridization to determine the cellular location of hsa_circ_0003748. A dual‐luciferase reporter gene assay revealed that has_circ_0003748 might bind the miRNA miR‐577. In hVIC cells (an RVHD cell line), Cell Counting Kit‐8, Transwell, and flow cytometry assays measured proliferation, migration, and cell cycle and apoptosis, respectively. We found that hsa_circ_0003748 was localized in the cytoplasm; hsa_circ_0003748 promoted the proliferation and migration of hVIC cells, arrested the cell cycle in the G2/M phase, and inhibited apoptosis. These phenomena may result from hsa_circ_0003748 promoting RVHD after sponging miR‐577. Bioinformatic analysis revealed that hsa_circ_0003748 might affect RVHD progression by affecting transcription and the MAPK signaling pathway, the Ras signaling pathway, the cAMP signaling pathway, the Rap1 signaling pathway, and other signaling pathways.
Evaluation of conventional and point‐of‐care real‐time RT‐PCR tests for the detection of SARS‐CoV‐2 through a pooled testing strategy
Authors: Yang Ji‐Rong , Kuo Chuan‐Yi , Huang Hsiang‐Yi , Yu I‐Ling , Hsieh Chih‐Tsun , Chen Bao‐Shan , Liu Ming‐Tsan 
Published: May 2022

AbstractBackgroundThe rapid identification and isolation of individuals infected with SARS‐CoV‐2 are fundamental countermeasures for the efficient control of the COVID‐19 pandemic, which has affected millions of people around the world. Real‐time RT‐PCR is one of the most commonly applied reference methods for virus detection, and the use of pooled testing has been proposed as an effective way to increase the throughput of routine diagnostic tests. However, the clinical applicability of different types of real‐time RT‐PCR tests in a given group size remains inconclusive due to inconsistent regional disease prevalence and test demands.MethodsIn this study, the performance of one dual‐target conventional and two point‐of‐care real‐time RT‐PCR tests in a 5‐specimen pooled testing strategy for the detection of SARS‐COV‐2 was evaluated.ResultsWe demonstrated the proof of concept that all of these real‐time RT‐PCR tests could feasibly detect SARS‐CoV‐2 from nasopharyngeal and oropharyngeal specimens that contain viral RNA loads in the range of 3.48 × 105 to 3.42 × 102 copies/ml through pooled testing in a group size of 5 with overall positive percent agreement (pooling vs. individual testing) ranging from 100% to 93.75%. Furthermore, the two POC real‐time RT‐PCR tests exhibited comparable sensitivity to that of the dual‐target conventional one when clinical specimens were tested individually.ConclusionOur findings support the feasibility of using real‐time RT‐PCR tests developed as a variety of platforms in routine laboratory detection of suspected COVID‐19 cases through a pooled testing strategy that is beneficial to increasing the daily diagnostic capacity.
Association of admissions factors with student performance in preclinical operative dentistry
Authors: Kornmehl David L. , Aldosari Muath , Tabassian Lilia J. , Park Sang E. , Ohyama Hiroe 
Published: May 2022

AbstractPurpose/ObjectiveAdmission to dental school is based on various factors including academic achievements in undergraduate coursework and the Dental Admission Test (DAT) scores. Students’ success in an operative course requires fundamental knowledge, hand skills, spatial awareness, and self‐assessment ability. The goal of this study is to evaluate how admissions factors, such as Grade Point Average (GPA) and DAT, including the Perceptual Ability Test (PAT), relate to students’ academic and preclinical performance and self‐assessment skills in preclinical operative dentistry.MethodsA total of 239 students were included from seven class years (2016–2022). Third‐year dental students participated in a preclinical operative dentistry course. At the end of the course, they took the final multiple‐choice exam and performed four competency examination procedures: Class II amalgam preparation and restoration and Class III resin‐composite preparation and restoration. Calibrated faculty graded students’ work independently and students also self‐assessed their performance using the same rubrics as faculty. Linear regressions were performed to estimate the association between the admission factors with the mean faculty scores (measuring preclinical performance), student‐faculty (S‐F) gap scores (evaluating self‐assessment skills), and their final didactic exam scores.ResultsOverall, students’ self‐assessment was higher compared to faculty score. Linear regression analysis demonstrated positive correlations between the PAT and students’ preclinical performance as well as between the DAT and their didactic exam scores. In general, S‐F gap score decreased as PAT score increased, and it was statistically significant lower for the Class III preparation, indicating a better self‐assessment skill. No correlations were observed between student performance and GPA scores.ConclusionThe findings from the association between student performance and admission factors may play an important role in the dental school admissions process and assist students who may benefit from early faculty intervention and support.
Improving the clinical accuracy and flexibility of the Alkaptonuria severity score index
Authors: Cant Harriet E. O. , Chatzidaki Iro , Olsson Birgitta , Rudebeck Mattias , Arnoux Jean‐Baptiste , Imrich Richard , Eddowes Lucy A. , Ranganath Lakshminarayan R. 
Published: May 2022

AbstractAlkaptonuria (AKU) is a rare genetic disorder where oxidised homogentisic acid accumulates in connective tissues, leading to multisystem disease. The clinical evaluation Alkaptonuria Severity Score Index (cAKUSSI) is a composite score that assesses the extent of AKU disease. However, some components assess similar disease features, are difficult to measure reliably or cannot be measured in resource‐limited environments. cAKUSSI data from the 4‐year SONIA 2 randomised controlled trial, which investigated nitisinone treatment in adults with AKU, were analysed (N = 125). Potentially biased or low‐information cAKUSSI measurements were identified using clinical and statistical input to create a revised AKUSSI for use in AKU research (cAKUSSI 2.0). Additionally, resource‐intensive measurements were removed to explore a flexible AKUSSI (flex‐AKUSSI) for use in low‐resource environments. Revised scores were compared to cAKUSSI in terms of correlation and how they capture disease progression and treatment response. Eight measurements were removed from the cAKUSSI to create the cAKUSSI 2.0, which performed comparably to the cAKUSSI in measuring disease extent, progression and treatment response. When removing resource‐intensive measurements except for osteoarticular disease, the flex‐AKUSSI was highly correlated with the cAKUSSI, indicating that they quantified disease extent similarly. However, when osteoarticular disease (measured using scans) was removed, the corresponding flex‐AKUSSI underestimated disease progression and overestimated treatment response compared to the cAKUSSI. Clinicians may use the cAKUSSI 2.0 to reduce time, effort and patient burden. Clinicians in resource‐limited environments may find value in computing a flex‐AKUSSI score, offering potential for future global registries to expand knowledge about AKU.
Principles for humanistic responsiveness to children and adolescents coping with the pandemic
Authors: Luke Chad 
Published: May 2022

AbstractPandemic stress can be a dehumanizing experience, especially for children and adolescents, and can be described in terms of the research paradigm of chronic variable stress (CVS). Humanistic counseling speaks to this particular kind of stress. This article presents eight principles for humanistic responsiveness for working with children and adolescents.
Attitudes, willingness, and resources to cover article publishing charges: The influence of age, position, income level country, discipline and open access habits
Authors: Segado‐Boj Francisco , Prieto‐Gutiérrez Juan‐Jose , Martín‐Quevedo Juan 
Published: May 2022

AbstractThe rise of open access (OA) publishing has been followed by the expansion of the Article Publishing Charges (APC) that moves the financial burden of scholarly journal publishing from libraries and readers to authors. We introduce the results of an international randomly selected sampled survey (N = 3,422) that explores attitudes towards this pay‐to‐publish or Gold OA model among scholars. We test the predictor role of age, professional position, discipline, and income‐level country in this regard. We found that APCs are perceived more as a global threat to Science than a deterrent to personal professional careers. Academics in low and lower‐middle income level countries hold the most unfavourable opinions about the APC system. The less experimental disciplines held more negative perceptions of APC compared to STEM and the Life Sciences. Age and access to external funding stood as negative predictors of refusal to pay to publish. Commitment to OA self‐archiving predicted the negative global perception of the APC. We conclude that access to external research funds influences the acceptance and the particular perception of the pay to publish model, remarking the economic dimension of the problem and warning about issues in the inequality between centre and periphery.
The motivations and criteria behind China's list of questionable journals
Authors: Zhang Lin , Wei Yahui , Sivertsen Gunnar , Huang Ying 
Published: May 2022

AbstractOn 31st December 2020, The National Science Library of the Chinese Academy of Sciences (CAS) released a list of 65 international scientific journals, all of them indexed by the Web of Science, that were said to be potentially in conflict with academic rigour. The list immediately influenced the publication patterns of Chinese researchers. A year later, on 31st December 2021, CAS released a revised and reduced list of 35 questionable journals and said the publishers in the meantime had reacted constructively and improved the procedures of their journals. This study aims to provide an understanding of the motivations and criteria behind the list, partly by reviewing Chinese policy documents and public debates, partly with a quantitative analysis to detect the relative importance of the criteria used to select the journals for the list.
Efficient fetal ultrasound image segmentation for automatic head circumference measurement using a lightweight deep convolutional neural network
Authors: Zeng Wen , Luo Jie , Cheng Jiaru , Lu Yiling 
Published: May 2022

AbstractPurposeFetal head circumference (HC) is an important biometric parameter that can be used to assess fetal development in obstetric clinical practice. Most of the existing methods use deep neural network to accomplish the task of automatic fetal HC measurement from two‐dimensional ultrasound images, and some of them achieved relatively high prediction accuracy. However, few of these methods focused on optimizing model efficiency performance. Our purpose is to develop a more efficient approach for this task, which could help doctors measure HC faster and would be more suitable for deployment on devices with scarce computing resources.MethodsIn this paper, we present a very lightweight deep convolutional neural network to achieve automatic fetal head segmentation from ultrasound images. By using sequential prediction network architecture, the proposed model could perform much faster inference while maintaining a high prediction accuracy. In addition, we used depthwise separable convolution to replace part of the standard convolution in the network and shrunk the input image to further improve model efficiency. After getting fetal head segmentation results, post‐processing, including morphological processing and least‐squares ellipse fitting, was applied to obtain the fetal HC. All experiments in this work were performed on a public dataset, HC18, with 999 fetal ultrasound images for training and 335 for testing. The dataset is publicly available on https://hc18.grand‐challenge.org/ and the code for our method is also publicly available on https://github.com/ApeMocker/CSM‐for‐fetal‐HC‐measurement.ResultsOur model has only 0.13 million [M] parameters and can achieve an inference speed of 28 [ms] per frame on a CPU and 0.194 [ms] per frame on a GPU, which far exceeds all existing deep learning‐based models as far as we know. Experimental results showed that the method achieved a mean absolute difference of 1.97( ± 1.89) [mm] and a Dice similarity coefficient of 97.61( ± 1.72) [%] on HC18 test set, which were comparable to the state of the art.ConclusionWe presented a very lightweight deep learning‐based model to realize fast and accurate fetal head segmentation from two‐dimensional ultrasound image, which is then used for calculating the fetal HC. The proposed method could help obstetricians measure the fetal HC more efficiently with high accuracy, and has the potential to be applied to the situations where computing resources are relatively scarce.