bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical profile and 90 day outcomes of 10 851 heart failure patients across India: National Heart Failure Registry
Authors: Harikrishnan Sivadasanpillai , Bahl Ajay , Roy Ambuj , Mishra Animesh , Prajapati Jayesh , Manjunath C.N. , Sethi Rishi , Guha Santanu , Satheesh Santhosh , Dhaliwal R.S. , Sarma Meenakshi , Ganapathy Sanjay , Jeemon Panniyammakal ,   for the NHFR investigators
Published: August 2022

AbstractAimsLimited data on the uptake of guideline‐directed medical therapies (GDMTs) and the mortality of acute decompensated HF (ADHF) patients are available from India. The National Heart Failure Registry (NHFR) aimed to assess clinical presentation, practice patterns, and the mortality of ADHF patients in India.Methods and resultsThe NHFR is a facility‐based, multi‐centre clinical registry of consecutive ADHF patients with prospective follow‐up. Fifty three tertiary care hospitals in 21 states in India participated in the NHFR. All consecutive ADHF patients who satisfied the European Society of Cardiology criteria were enrolled in the registry. All‐cause mortality at 90 days was the main outcome measure. In total, 10 851 consecutive patients were recruited (mean age: 59.9 years, 31% women). Ischaemic heart disease was the predominant aetiology for HF (72%), followed by dilated cardiomyopathy (18%). Isolated right HF was noted in 62 (0.6%) participants. In eligible HF patients, 47.5% received GDMT. The 90 day mortality was 14.2% (14.9% and 13.9% in women and men, respectively) with a re‐admission rate of 8.4%. An inverse relationship between educational class based on years of education and 90 day mortality (high mortality in the lowest educational class) was observed in the study population. Patients with HF with reduced ejection fraction and HF with mildly reduced ejection fraction who did not receive GDMT experienced higher mortality (log‐rank P < 0.001) than those who received GDMT. Baseline educational class, body mass index, New York Heart Association functional class, ejection fraction, dependent oedema, serum creatinine, QRS > 120 ms, atrial fibrillation, mitral regurgitation, haemoglobin levels, serum sodium, and GDMT independently predicted 90 day mortality.ConclusionOne of seven ADHF patients in the NHFR died during the first 90 days of follow‐up. One of two patients received GDMT. Adherence to GDMT improved survival in HF patients with reduced and mildly reduced ejection fractions. Our findings call for innovative quality improvement initiatives to improve the uptake of GDMT among HF patients in India.
Investigation of Behavioural Pain Scale, Critical Care Pain Observation Tool, nociceptive flexion reflex and pupillary dilatation reflex as predictors of behavioural reactions to nociceptive procedures in critically ill patients unable to self‐report pain
Authors: Jurth Carlo , Zimmermann Valerie , Schaaf Luisa , Lezius Franziska , Bublitz Viktor K. , Lichtner Gregor , von Dincklage Falk 
Published: August 2022

AbstractBackgroundProcedural pain is a common burden in critical care treatment and the prediction of nociceptive reactions remains challenging. Thus, we investigated the Behavioural Pain Scale (BPS), the Critical Pain Observational Tool (CPOT), the nociceptive flexion reflex (NFR), the pupillary dilation reflex (PDR) and the Richmond Agitation–Sedation Scale (RASS) as predictors of behavioural reactions to nociceptive procedures.MethodsIn this monocentric, prospective, observational study, we analysed data of 128 critically ill adults unable to self‐report pain to investigate the predictability of behavioural reactions to two procedures: endotracheal suctioning and turning. Next to routine clinical data, CPOT, BPS, PDR, NFR, RASS, propofol and sufentanil doses were recorded before the procedures.ResultsFor endotracheal suctioning, NFR, BPS, CPOT and RASS showed predictive performances significantly better than chance, but none of them performed significantly better than the sufentanil dose rate. For turning, BPS, CPOT and RASS showed predictive performances significantly better than chance, but only the RASS performed significantly better than the propofol dose rate.ConclusionsBehavioural reactions to both investigated clinical procedures can be predicted by observational scales or nociceptive reflexes. For endotracheal suctioning, none of the predictors performed superior to using the sufentanil dose rate as a predictor. As using sufentanil as a predictor requires no extra effort in contrast to the other predictors, none of the here investigated tools seem advisable for predicting behavioural reactions to endotracheal suctioning. For patient turning, the RASS predicts reactions better than any other tool.SignificanceIn this observational study, we demonstrate that behavioural reactions to potentially nociceptive procedures in critical care treatment can be predicted by observational scales and nociceptive reflexes. However, for endotracheal suctioning, none of the predictors is superior to using the opioid dose rate as a predictor. For patient turning, the RASS predicts reactions better than any other parameters.
Comparison of microwave pyrolysis and conventional pyrolysis of Eupatorium adenophorum
Authors: Lin Jin , Cheng Song , Zhao Saidan , Liu Yongzhi , Xia Hongying , Xing Baolin 
Published: August 2022

AbstractEupatorium adenophorum is used as the raw material to produce valuable pyrolysis products by microwave pyrolysis (MP). The influence of pyrolysis parameters (pyrolysis temperature, pyrolysis time and nitrogen flow rate) on the yield of pyrolysis products is investigated to get the optimal pyrolysis condition. Eupatorium adenophorum is also conducted in the conventional pyrolysis (CP) to investigate the influence of heat mechanism on the generation process of pyrolysis products. A comparison of MP and CP indicates that MP produces more bio‐gas (48.14%), and less bio‐oil (26.35%) compared to CP. The less carboxylic acid and more phenol in bio‐oil of MP are observed in the condition of MP compared to CP, indicating that MP could upgrade the quality of bio‐oil. Bio‐gas of MP has larger content of H2 and syngas (H2 + CO) than those obtained from CP. The property of bio‐char from MP is better than that of CP in terms of heat value, oxygen content, and specific surface area, which could be utilized in the metallurgical industry.
Association of Urinary Pentosidine Levels With the Risk of Fractures in Patients With Severe Osteoporosis: The Japanese Osteoporosis Intervention Trial‐05 (JOINT‐05)
Authors: Tanaka Shiro , Saito Mitsuru , Hagino Hiroshi , Mori Satoshi , Nakamura Toshitaka , Ohta Hiroaki , Sone Teruki , Takahashi Kaito , Mitomo Yuji , Sugimoto Toshitsugu , Soen Satoshi ,   Adequate Treatment of Osteoporosis (A‐TOP) Research Group
Published: August 2022

ABSTRACTAssociations between urinary pentosidine, one of the advanced glycation end products in collagen, and the risk of fracture in patients with severe osteoporosis are unknown. In this study, we investigated whether the urinary pentosidine level is associated with the incidence of morphometric vertebral fracture and nonvertebral fracture using data of a randomized, controlled trial, JOINT‐05. JOINT‐05 enrolled Japanese women aged 75 years or older with primary osteoporosis. Patients were randomly assigned (1:1) to receive sequential therapy (teriparatide followed by alendronate) or monotherapy with alendronate for 120 weeks. Incidences of vertebral and nonvertebral fractures were assessed morphologically. During treatment, urinary levels of pentosidine and serum levels of bone turnover markers (osteocalcin, procollagen type I amino‐terminal propeptide, and tartrate‐resistant acid phosphatase 5b) were measured. A total of 967 patients with baseline pentosidine levels were included in the study. Of these, 137 had vertebral fractures, and 42 had nonvertebral fractures. The rate ratios for vertebral fracture for the second (30–39 pmol/mL), third (40–49 pmol/mL), and fourth quartile (≥50 pmol/mL) groups divided by pentosidine level compared with the first quartile (<30 pmol/mL) group were 1.65 (95% confidence interval [CI] 0.99–2.75, p = 0.06), 1.51 (95% CI 0.87–2.61, p = 0.14), and 1.69 (95% CI 1.01–2.83, p = 0.05), respectively. The corresponding rate ratios for nonvertebral fracture were 3.07 (95% CI 0.88–10.70, p = 0.08), 2.34 (95% CI 0.61–8.95, p = 0.22), and 3.95 (95% CI 1.14–13.67, p = 0.03), respectively. The association of the urinary pentosidine level with the incidence of nonvertebral fracture was the strongest among the biomarkers assessed in the study. In conclusion, the urinary pentosidine level was associated with the risk of fracture in patients with severe osteoporosis receiving teriparatide or alendronate. © 2022 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
COVID‐19 and pre‐tenure counseling faculty: A collaborative autoethnographic investigation
Authors: Peters Harvey Charles , Das Bagmi , Attia Mina , Parker Maggie M. 
Published: August 2022

AbstractHigher education faculty worldwide experienced heightened stressors due to the COVID‐19 pandemic, from completing their professional roles and responsibilities virtually to balancing personal and professional stressors. Consequently, the pandemic created many adjustments for pre‐tenure counseling faculty across research, teaching, and service. In response to this pandemic, we explored the impact of the COVID‐19 pandemic on the personal and professional lives of four pre‐tenure counseling faculty members. Accordingly, we used collaborative autoethnography to investigate our experiences and narratives as pre‐tenure counseling faculty, which resulted in seven overarching themes. We discussed the implications for practice, advocacy, education, and faculty training.
Gait biomechanics after proximal femoral nailing of intertrochanteric fractures
Authors: Sivakumar Arjun , Rickman Mark , Thewlis Dominic 
Published: August 2022

AbstractProximal femur fractures in the elderly are associated with significant loss of independence, mobility, and quality of life. This prospective study aimed to: (1) investigate gait biomechanics in intertrochanteric fracture (ITF) patients (A1 and A2 AO/OTA) managed via femoral nailing at 6 weeks and 6 months postoperative and how these compared with similarly aged elderly controls; and (2) investigate whether femoral offset shortening (FOS) and lateral lag screw protrusion (LSP) were associated with changes in gait biomechanics at postoperative time points. Hip radiographs and gait data were collected for 34 patients at 6 weeks and 6 months postoperatively. Gait data were also collected from similarly aged controls. FOS and LSP were measured from radiographs. Joint angles, external moments, and powers were calculated for the hip, knee, and ankle and compared between time points in ITF patients and healthy controls using statistical parametric mapping. The relationship between radiographic measures with gait speed, step length, peak hip abduction, and maximum hip abduction moment was assessed using a Pearson correlation. External hip adduction moments and hip power generation improved in the first 6 months postoperative, but differed significantly from healthy controls during single limb stance. LSP showed a moderate correlation with maximum hip abduction moment at 6 weeks postoperative (r = −0.469, p = 0.048). These results provide new detail on functional outcomes after ITF and potential mechanisms that functional deficiencies may stem from. Lag screw prominence may be an important factor in maintaining functional independence and minimizing the risk of secondary falls after ITF in the elderly.
Surgical technique and comparison of autologous cancellous bone grafts from various donor sites in rats
Authors: Gens Lena , Marchionatti Emma , Steiner Adrian , Stoddart Martin J. , Thompson Keith , Mys Karen , Zeiter Stephan , Constant Caroline 
Published: August 2022

AbstractAutologous cancellous bone graft is the gold standard in large bone defect repair. However, studies using autologous bone grafting in rats are rare. To determine the feasibility of autologous cancellous bone graft harvest from different anatomical donor sites (humerus, ilium, femur, tibia, and tail vertebrae) in rats and compare their suitability as donor sites, a total of 13 freshly euthanized rats were used to describe the surgical technique, determine the cancellous bone volume and microstructure, and compare the cancellous bone collected quantitatively and qualitatively. It was feasible to harvest cancellous bone grafts from all five anatomical sites with the humerus and tail being more surgically challenging. The microstructural analysis using micro‐computed tomography showed a significantly lower bone volume fraction, bone mineral density, and trabecular thickness of the humerus and iliac crest compared to the femur, tibia, and tail vertebrae. The harvested weight and volume did not differ between the donor sites. All donor sites apart from the femur yielded primary osteogenic cells confirmed by the presence of alkaline phosphatase and Alizarin Red S stain. Bone samples from the iliac crest showed the most consistent outgrowth of osteoprogenitor cells. In conclusion, the tibia and iliac crest may be the most favorable donor sites considering the surgical approach. However, due to the differences in microstructure of the cancellous bone and the consistency of outgrowth of osteoprogenitor cells, the donor sites may have different healing properties, that need further investigation in an in vivo study.
Surface‐enhanced Raman spectroscopy is an accurate technique in diagnosis of breast cancer: A meta‐analysis
Authors: Yue Xiang , Wang Yashan , Guo Dingjie , He Guangliang , Sui Chuanying , Qu Zihan , Zhao Yinlong , Liu Xin 
Published: August 2022

AbstractThe meta‐analysis was prepared to evaluate the diagnostic value of surface‐enhanced Raman spectroscopy for patients with breast cancer and to provide some statistically significant reference for the detection process. PubMed, Web of Science, Cochrane library, and Embase databases were retrieved for randomized clinical trials by two independent reviewers. A comprehensive search was performed on July 15, 2022. Meta‐Disc 1.4 was used to calculate Spearman correlation coefficient. STATA 14.1 software was used to evaluate the diagnostic effect and the performance of subgroup analysis, which could be conducted to explore the potential sources of heterogeneity. Review manager 5.3 software was performed for quality assessment in our meta‐analysis. The results displayed 19 studies with 1299 patients were included according to the inclusion and exclusion criteria. Meta‐analysis displayed the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and the area under the curve of using surface enhanced Raman spectroscopy for diagnosing the patients with breast cancer were 0.91 (95% CI 0.85–0.94), 0.94 (95% CI 0.91–0.96), 14.06 (95% CI 9.25–21.35), 0.10 (95% CI 0.06–0.17), 140.64 (95% CI 59.63–331.70), and 0.97 (95% CI 0.95–0.98), respectively. The source of specificity heterogeneity was from different sample volume mixed with nanoparticle. Surface‐enhanced Raman spectroscopy had high sensitivity and specificity in the diagnosis of breast cancer. It was an accurate and effective technique for patients with breast cancer.
Bargaining our emotions: Exploring the lived experience of purchasing luxury fashion counterfeit
Authors: Bardey Aurore C. , Turner Rose , Piccardi Patrice 
Published: August 2022

AbstractThe study identified contrasting experiences of purchasing and owning luxury fashion counterfeit items: while some participants carefully considered and were ultimately satisfied with their counterfeit purchase, others impulsively purchased and later reappraised and regretted their decision. The findings underlined the importance of consumer perceptions of quality to luxury and luxury counterfeit fashion products. They showed how education about the unethical features of the counterfeit industry could change consumer behavior.
Breast cancer‐related lymphedema correlated with incidence of cellulitis and mortality
Authors: Cheng Ming‐Huei , Ho Olivia A. , Tsai Tai‐Jung , Lin Yi‐Ling , Kuo Chang‐Fu 
Published: August 2022

AbstractBackgroundThis study investigated breast cancer‐related lymphedema (BCRL) and its correlation with the incidence of cellulitis and mortality in the National Health Insurance (NHI) database in Taiwan.MethodsBetween 2004 and 2014, the NHI database of patients with breast cancer who underwent surgical procedures, adjuvant therapies, BCRL, cellulitis, and mortality were retrospectively reviewed. Cox regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for incidence of BCRL and cellulitis in different treatment groups. The associations of BCRL with the incidence of cellulitis and mortality were further analyzed using the Kaplan–Meier curve.ResultsAmong 100 301 patients, 5464 (5.4%) developed BCRL with a median onset of 1.3 years. At a mean follow‐up of 4.77 years, the incidence of cellulitis in the BCRL group (12.7%, 694/5464 patients) was significantly higher than in the no‐BCRL group (2.73%, 2589/94 837 patients) (HR: 3.74; 95% CI: 3.43–4.08; p < 0.0001). At a mean follow‐up of 5.77 years, the mortality rate in the cellulitis group (34.21%, 1123/3283 patients) was significantly greater than in the no‐cellulitis group (16.29%, 15 804/97 018 patients) (HR: 1.17; 95% CI: 1.1–1.24; p < 0.0001).ConclusionsBCRL had a significantly higher incidence of cellulitis and mortality.
Phase 1/1b Studies of UCB0599, an Oral Inhibitor of α‐Synuclein Misfolding, Including a Randomized Study in Parkinson's Disease
Authors: Smit Johan Willem , Basile Peter , Prato Maria Key , Detalle Laurent , Mathy François‐Xavier , Schmidt Astrid , Lalla Marianna , Germani Massimiliano , Domange Coralie , Biere Anja‐Leona , Bani Massimo , Carson Stan , Genius Just 
Published: August 2022

AbstractBackgroundParkinson's disease (PD) and its progression are thought to be caused and driven by misfolding of α‐synuclein (ASYN). UCB0599 is an oral, small‐molecule inhibitor of ASYN misfolding, aimed at slowing disease progression.ObjectiveThe aim was to investigate safety/tolerability and pharmacokinetics (PK) of single and multiple doses of UCB0599.MethodsSafety/tolerability and PK of single and multiple doses of UCB0599 and its metabolites were investigated in two phase 1 studies in healthy participants (HPs), where food effect and possible interaction with itraconazole (ITZ) were assessed (UP0030 [randomized, placebo‐controlled, dose‐escalation, crossover study, N = 65] and UP0078 [open‐label study, N = 22]). Safety/tolerability and multi‐dose PK of UCB0599 were subsequently investigated in a phase 1b randomized, double‐blind, placebo‐controlled study of participants with PD (UP0077 [NCT04875962], N = 31).ResultsAcross all studies, UCB0599 displayed rapid absorption with linear, time‐independent PK properties; PK of multiple doses of UCB0599 were predictable from single‐dose exposures. No notable food‐effect was observed; co‐administration with ITZ affected UCB0599 disposition (maximum plasma concentration and area under the curve increased ~1.3‐ and ~2 to 3‐fold, respectively) however, this did not impact the safety profile. Hypersensitivity reactions were reported in UP0030 (n = 2) and UP0077 (n = 2). Treatment‐related adverse events occurred in 43% (UCB0599), and 30% (placebo) of participants with PD were predominantly mild‐to‐moderate in intensity and were not dose related.ConclusionsSeventy‐three HPs and 21 participants with PD received UCB0599 doses; an acceptable safety/tolerability profile and predictable PK support continued development of UCB0599 for the slowing of PD progression. A phase 2 study in early‐stage PD is underway (NCT04658186). © 2022 UCB Pharma. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Assessing Size-Dependent Population-Level Effects of Largemouth Bass Tournament Mortality
Authors: Sylvia Andrea , Weber Michael J. 
Published: August 2022

Abstract
As black bass Micropterus spp. tournaments continue to grow in popularity, so too must evaluations on the population-level effects of live-release angling events. Although factors influencing the tournament mortality of individuals are well studied, assessments at the population level are lacking. We evaluated differences in tournament capture probability and survival of two size-classes of Largemouth Bass M. salmoides (medium: 381–457 mm; large: &gt;457 mm) using a multistate mark–recapture model. Changes in estimated capture and survival rates of medium and large bass were then simulated to assess potential effects on population size structure. Tournament capture probabilities for medium bass were approximately three times higher than those for large bass, and tournament capture probabilities for both size-classes increased with air temperature. Medium bass also experienced higher survival rates than large bass after tournaments, and survival rates of both groups declined with increasing water temperature. Our simulations indicated that both increases in tournament capture probability and reductions in posttournament survival of large bass resulted in some reductions in population size structure. However, increases in tournament capture probability or reductions in tournament survival of medium bass or medium and large bass alone had little to no effect. Our results suggest that under the observed tournament conditions, tournaments have little effect on bass population size structure, but size structure could be reduced with higher capture probabilities and lower posttournament survival; this information is useful for managing the fishery effects of tournament angling. Our modeling approach also provides a framework for understanding population-level effects of tournaments on other populations under alternative conditions.
Caffeine facilitates extinction of auditory fear conditioning in rats
Authors: Ozawa Takaaki , Kaseda Kodai , Ichitani Yukio , Yamada Kazuo 
Published: August 2022

AbstractCaffeine is the most widely consumed psychostimulant drug which could affect learning and memory acting through central adenosine receptors. Although caffeine has been suggested to impair the acquisition and the expression of auditory fear conditioning, its effect on the extinction has not been elucidated. To address this issue, in the present study, we investigated whether caffeine affects the extinction of conditioned fear in an auditory fear conditioning paradigm. During conditioning, rats received pairings of auditory cues (conditioned stimulus, CS) and foot shocks (unconditioned stimulus). On the next day, the rats were intraperitoneally administrated saline or caffeine (5 or 10 mg/kg) and then subjected to the extinction training, in which CSs were repeatedly presented without the foot shocks. Twenty‐four hours later, the rats were re‐exposed to the presentations of CSs (retrieval test). We found an acute caffeine administration dose‐dependently decreased freezing rates during the presentations of CS in the extinction training. Furthermore, caffeine‐treated animals showed lower conditioned freezing responses in the retrieval test. These findings suggest that caffeine facilitates the extinction of conditioned fear.