bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synchronous isolated gastric metastases from ascending colon carcinoma, a case report
Authors: Yang Bin , Gan Zhonghua , Liu Shulan , Li Mingxia , guangyan Si 
Published: March 2022

Abstract
Background
Gastric metastases (GM) are rare and often accompanied with synchronous metastases of other organs. Synchronous isolated gastric metastases from ascending colon carcinoma are uncommon and rarely studied. Gastric metastases may be confused with primary gastric tumors.
Case presentation:
A rare case of synchronous isolated gastric metastasis from ascending colon carcinoma was confirmed by computed tomography (CT) and pathological diagnosis. A 45-year-old man presented to our hospital with abdominal distension and anal pendant expansion. The abdominal physical examination was negative. The positive fecal occult blood test and the negative tumor marker were obtained. Colonoscopy and gastroduodenoscopy revealed a polypoidal lesion in the ascending colon and a polypoid mass in the gastric body, respectively. CT showed the thickened wall of ascending colon and polypoid mass in the gastric body with homogenous enhancement. Additionally, synchronous gastric metastases from the ascending colon carcinoma were confirmed by pathology after laparoscopic right hemicolectomy and partial gastrectomy. After 13 individual doses of fluorouracil (2.8g/time), calcium leucovorin (0.8g/time), and oxaliplatin (85mg/time), the patient was discharged without any discomfort, without any additional metastases detected during the following 18 months.
Conclusion
GM may appear as a polypoid lesion. Surgery combined with chemotherapy may improve the prognosis in patients with synchronous isolated GM.
Supporting routine cognitive reactivity assessment in the perinatal period: psychometric testing of the Chinese version of the Leiden Index of Depression Sensitivity
Authors: Fu Yanqing , Lin Yu-an , Zheng Jiansheng , Hong Huilan , Huang Songqing , Li Jiang , Huang Feifei 
Published: March 2022

Abstract
Background
Finding optimal forms to recognize perinatal depression and its vulnerable factors and making them more applicable to depression screening is critical. This study aims to evaluate the reliability and validity of the Chinese version of he Leiden Index of Depression Sensitivity (LEIDS-RR) among perinatal women in China and determine cut-off values for screening high-risk depression.
Methods
In the third trimester of pregnancy and at six-weeks postpartum, women completed the LEIDS-RR-CV and a diagnostic reference standard online. We assessed the LEIDS-RR-CV using classical test theory and item response theory (IRT). The test performance for cut-off scores to screen for high-risk depression at each time point was assessed using receiver operator characteristic analysis.
Results
In total, 396 (third trimester) and 321 (six-weeks postpartum) women participated. Cronbach’s alpha, two-week test-retest reliability, and marginal reliability for the scale were all greater than 0.8. It showed a five-factor model, and the cut-off values were 58 (third trimester) and 60 (six-weeks postpartum). The areas under the curve were acceptable (≥ 0.7), and the LEIDS-RR-CV was positively correlated with the total Edinburgh Postnatal Depression Scale (EPDS) score (r = 0.52 and 0.56, p = 0.00), indicating its predictive validity. IRT analysis confirmed its discriminative validity.
Conclusions
The LEIDS-RR-CV was shown to be reliable, valid, and can be used to quantify cognitive reactivity in perinatal Chinese women and for screening for high-risk depression during this period.
Parametric study of cold wire tandem submerged arc welding of heavy gauge X70 linepipe steel
Authors: Ren Tailin , Mohammadijoo Mohsen , Wiskel J Barry , Lazor Robert , Willett Eric , Ivey Douglas G. , Henein Hani 
Published: March 2022

Abstract
Cold wire tandem submerged arc welding (CWTSAW) has been developed to improve the productivity (i.e., deposition rate and travel speed), and to control the weld and heat-affected zone (HAZ) geometry and mechanical properties of heavy gauge pipe. A series of CWTSAW trials were conducted on thick-wall American Petroleum Institute (API) X70 steel plates to investigate the effect of cold wire feed speed (CWFS), heat input (HI) and bevel design (BD) on the resulting geometry (e.g., height of reinforcement area (HRA), bead toe angle (BTA) and coarse grain heat-affected zone (CGHAZ) area) and micro-hardness of the weld and HAZ. The phase fraction of martensite-austenite (MA) constituents was measured using optical microscopy (OM) and scanning electron microscopy (SEM). Vickers micro-hardness measurements were taken of the weld metal and across the HAZ. The geometry and hardness measurements were statistically correlated with the weld parameters using Taguchi methodology. The results showed that the weld bevel design (BD) was the dominant factor influencing the HRA, CGHAZ area and BTA. Cold wire feed speed (CWFS) had a strong influence on the micro-hardness and phase fraction of MA constituents in the CGHAZ.
Network motifs shape distinct functioning of Earth’s moisture recycling hubs
Authors: Wunderling Nico , Wolf Frederik , Tuinenburg Obbe , Staal Arie 
Published: March 2022

Abstract
Earth's hydrological cycle critically depends on the atmospheric moisture flows connecting evaporation to precipitation. Here, we convert a decade of reanalysis-based moisture simulations into a high-resolution global directed network of spatial moisture provisions. We reveal global and local network structures that offer a new view of the global hydrological cycle. We identify four terrestrial moisture recycling hubs: the Amazon Basin, the Congo Rainforest, South Asia and the Indonesian Archipelago. Network motifs reveal contrasting functioning of these regions, where the Amazon strongly relies on directed connections (feed-forward loops) for moisture redistribution and the other hubs on reciprocal moisture connections (zero loops and neighboring loops). Earth's moisture recycling hubs are characterized by specific topologies shaping heterogeneous effects of land-use changes and climatic warming on precipitation patterns.
Fetal Echocardiographic Variables Associated with Perinatal Mortality in Truncus Arteriosus – A Pilot Study
Authors: Cox Kelly , Husain Nazia , Geiger Miwa , Jhaveri Simone , Berhane Haben 
Published: March 2022

Abstract
Background: Truncus arteriosus (TA) is a rare congenital heart defect that can be prenatally detected by fetal echocardiography. However, prognostication and prenatal counseling focus primarily on surgical outcomes due to limited fetal and neonatal pre-surgical mortality data. We aimed to describe the incidence and identify predictors of perinatal pre-surgical mortality in prenatally detected TA. Methods: This two-center, retrospective cohort study included fetuses diagnosed with TA between 01/2010 and 04/2020. The primary outcome was perinatal mortality, defined by fetal or neonatal pre-surgical death or transplantation prior to discharge. Univariable regression modeling and Chi-square test assessed for associations between prenatal clinical, demographic, and fetal-echo variables and perinatal mortality. Results: Of 23 pregnancies with prenatal diagnosis of TA, 4(17%) were terminated. Of the remaining 19, perinatal mortality occurred in 4(26%), including 2(11%) fetal deaths and 2(11%) neonatal pre-surgical deaths. No transplantation listings. Of liveborn fetuses(n=17), 15(88%) underwent a neonatal surgery, and 1(6%) required ECMO. As compared to the survivors, the perinatal mortality group had a higher likelihood of having left ventricular dysfunction (0%vs.40%;p=0.01), right ventricular dysfunction (0%vs.60%;p=0.002), cardiovascular profile score(CVP)<7(0%vs.40%;p=0.01), skin edema (0%vs.40%;p=0.01), and abnormal umbilical venous(UV) Doppler (60%vs.0%;p=0.002). Presence of truncal valve regurgitation or stenosis neared significance. Conclusion: In prenatally diagnosed TA, there is significant perinatal mortality, including fetal death and neonatal pre-surgical death. Termination rate is also high. Fetal echocardiographic variables associated with perinatal mortality include ventricular dysfunction, low CVP, skin edema, and abnormal UV Doppler. Knowledge about prenatal risk factors for perinatal mortality may guide parental counseling and guide postnatal planning in prenatally diagnosed TA.
Hearing in African Pygmy Hedgehogs (Atelerix albiventris): Audiogram, Sound Localization, and Ear Anatomy
Authors: Heffner Rickye S. , Koay Gimseong , Heffner Henry E. , Mason Matthew J. 
Published: March 2022

Abstract
The behavioral audiogram and sound localization performance, together with the middle and inner ear anatomy, were examined in African pygmy hedgehogs Atelerix albiventris. Their auditory sensitivity at 60 dB SPL extended from 2 kHz-46 kHz, revealing a relatively narrow hearing range of 4.6 octaves, with a best sensitivity of 21 dB at 8 kHz. Their noise-localization acuity around the midline (minimum audible angle) was 14°, matching the mean of terrestrial mammals. The African pygmy hedgehog was not able to localize low-frequency pure tones or a 3-kHz amplitude-modulated tone when forced to rely on the interaural phase-difference cue, a trait shared by at least nine other mammals. The middle ear of Atelerix has a primitive configuration including an unfused ectotympanic, a substantial pars flaccida, a synostosed malleo-tympanic articulation and a ‘microtype’ malleus. A similar malleus morphology, including a stiff articulation with the skull, is a consistent feature of other mammals that do not hear frequencies below 400 Hz. The hearing of A. albiventris is discussed relative to the broad range of hearing and sound localization abilities found in mammals.
Re-exploring the inflammation-related core genes and modules in cerebral ischemia
Authors: Lv Wenjing , Jiang Junqi , Xu Yi , Chen Zhiyuan , Wang Zixuan , Xing Ang , Zheng Xueping , Qu Tingting , Wan Qi 
Published: March 2022

Abstract
The genetic transcription profile of brain ischemic and reperfusion injury remains elusive. To address this, we used an integrative analysis approach including differentially expressed genes (DEGs) analysis, weighted-gene co-expression network analysis (WGCNA), and pathway and biological processes analysis to analyze data from the microarray studies of nine mice and five rats after middle cerebral artery occlusion (MCAO), and six primary cell transcriptional datasets in the Gene Expression Omnibus (GEO). We identified reperfusion as the main confounding factor in gene profile changes. Our analyses of pathway and biological processes revealed upregulated functional modules involved in inflammatory disequilibrium and thrombus formation. Astrocytes, microglia, and macrophages were the main contributors of inflammation-related gene changes. Novel core hubs implicated in negative regulation of inflammation (Zfp36, Nfkbiz, and Maff) were identified and validated. Collectively, these results expand our knowledge of the genetic profile involved in brain ischemia and reperfusion, highlighting the crucial role of inflammatory disequilibrium in brain ischemia.
Biodynamic Certification in Brazil
Authors: Vargas Rayan , Dörr Andréa , de Oliveira Jéssica , Franco Fernando 
Published: March 2022

Abstract
Background: The certification process was a legal milestone for Biodynamic agriculture, because through this standardization process, the principles initially proposed by Steiner for agriculture were legitimized. Through this aegis of legality, the associations and institutes of the biodynamic movement managed to establish themselves and grow in the 20th century, especially after the second world war. Due to the importance of this recognition, this article seeks to understand the trajectory of Biodynamic certification in Brazil, as well as the institutions linked to the certification process. Materials and methods: A descriptive study of the certification process was carried out, characterized by a study that focuses on precise and explicit objectives about the observed facts describing the characteristics of a phenomenon or group of individuals, in the research in question, the agents involved in the certification process, as well as the certifying institutions located in Brazil. Bibliographic research was also conducted on the theme and semi-structured interviews with agents of the Biodynamic movement in Brazil. Results: The history of Biodynamics in Brazil is by no means dissociated from the history of the movement started in 1924 by Steiner's agricultural course. The first immigrants to practice Biodynamic agriculture on Brazilian soil were German farmers who left their country of origin in 1939, a time of expansion of the Experimental Circle and full dissemination of Steiner's principles throughout the world, with the creation of associations in several countries. In Brazil, the audited certification process is 29 years old and is currently carried out by the Instituto de Certificação Biodinâmica (IBD). The Participatory Guarantee System (PGS), originating from the organic movement, has as diffusers the Biodynamic Agriculture Association and the Association of Biodynamic Farmers of the South.Conclusion: IBD moves away from the Biodynamic movement, embracing the different labels that meet the new food trends, acquiring a more entrepreneurial character, and abandoning the principles by which it was founded. The GSP is promising when it merges the legitimacy of the standard with more personal relationships allowing the exchange of knowledge among members, this ability to exchange knowledge brings it closer to the roots of the Biodynamic movement.
Long-term Neurologic Outcomes of COVID-19
Authors: Al-Aly Ziyad , Xie Yan , Xu Evan 
Published: March 2022

Abstract
The neurologic manifestations during the acute phase of COVID-19 are well characterized, but a comprehensive evaluation of the risks and burdens of post-acute neurologic disorders at 1-year after the initial infection has not been yet undertaken. Here we use national healthcare databases from the US Department of Veterans Affairs to build a cohort of 154,068 individuals with COVID-19 as well as two sets of control cohorts with 5,638,795 (contemporary controls) and 5,859,621 (historical controls) individuals to estimate risks and burdens of a set of pre-specified incident neurologic disorders at 12 months. Our results show that in the post-acute phase of COVID-19, there was increased risk of an array of neurologic disorders including stroke, cognition and memory disorders, peripheral nervous system disorders, episodic disorders (e.g., migraine and seizure), extrapyramidal and movement disorders, musculoskeletal disorders, sensory disorders, and other disorders including Guillain-Barré, and encephalitis or encephalopathy. The risks and burdens were significantly elevated even in people who did not require hospitalization during the acute phase of COVID-19. Taken together, our results provide evidence of increased risk of broad array of long-term neurologic disorders in people with COVID-19. This evidence will inform the management of the ongoing pandemic and guide post-acute COVID-19 clinical care and health care systems planning.
Fibravasc: a method to assess the vascularization of main white matter fiber tracts
Authors: Smirnov Mykyta , Maldonado Igor Lima , Destrieux Christophe 
Published: March 2022

Abstract
Advances in the techniques for assessing human cerebral white matter have recently contributed to greater attention to structural connectivity. Yet, little is known about the vascularization of most white matter fasciculi and the fascicular composition of the vascular territories. This paper presents an original method to label the arterial supply of macroscopic white matter fasciculi based on a standardized protocol for post-mortem injection of colored material combined with a novel fiber dissection technique. A detailed description of every step, from obtaining the specimen to image acquisition of its dissection, is provided. Injection and dissection results show the reproducibility and feasibility of the protocol. In addition, we discuss the challenges we faced and overcame during the development of the presented method, highlight its originality, and briefly review the white matter's place in modern clinical practice and research.
Girls’ education can be a driving force for the attainment of several sustainable development goals – A case study from Zimbabwe
Authors: G Venkatesh 
Published: March 2022

Abstract
Thanks to the collaboration among, and the dedication and determination of, entities committed to sustainable development in the developing world – Plan USA, an eminent American university and donors - a robust instance of sustainability, which can inspire several similar projects around the world, struck root in rural Zimbabwe during the pandemic. Centred on the education, health and welfare of girls, it shows tremendous promise in kick-starting progress towards a clutch of sustainable development goals. Intuitively, as well as empirically, it is at once clear that education – especially that of girls in the developing world countries – holds the key to ‘sustained and sustainable development’. While this is just a brief communication, actual progress can be measured using suitable metrics and indicators, in the future.
Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 induces microglial activation and M1 polarization via the MAPK-NF-κB signaling pathway
Authors: Oh Yebin , Jung Hak-Jun , Hong Seungwon , Cho Yerim , Cho Daeho , Kim Tae Sung 
Published: March 2022

Abstract
BackgroundActivation of microglia, which are the primary immune cell of the central nervous system, plays an important role in neuroinflammation associated with several neuronal diseases. Aminoacyl tRNA synthetase (ARS) complex-interacting multifunctional protein 1 (AIMP1), a structural component of the multienzyme ARS complex, is secreted to trigger a pro-inflammatory function and has been associated with several inflammatory diseases. However, the effect of AIMP1 on microglial activation remains unknown. ResultsAIMP1 elevated the expression levels of activation-related cell surface markers and pro-inflammatory cytokines in primary and BV-2 microglial cells. In addition to the AIMP1-mediated increase in the expression levels of M1 markers (interleukin (IL)-6, tumor necrosis factor-α, and IL-1β), the expression levels of CD68, an M1 cell surface molecule, were also increased in AIMP-1-treated microglial cells, while those of CD206, an M2 cell surface molecule, were decreased, indicating that AIMP1 triggers the polarization of microglial cells into the M1 state but not the M2 state. AIMP1 treatment induced the phosphorylation of mitogen-activated protein kinases (MAPKs), while MAPK inhibitors suppressed the AIMP1-induced microglial cell activation. AIMP1 also induced the phosphorylation of the nuclear factor-kappa B (NF-κB) components and nuclear translocation of the NF-κB p65 subunit in microglial cells. Furthermore, c-Jun N-terminal kinase (JNK) and p38 inhibitors markedly suppressed the AIMP1-induced phosphorylation of NF-κB components as well as the nuclear translocation of NF-κB p65 subunit, suggesting the involvement of JNK and p38 as upstream regulators of NF-κB in AIMP1-induced microglial cell activation.ConclusionAIMP1 effectively induces M1 microglial activation via the JNK and p38/NF-κB-dependent pathways. These results suggest that AIMP1 secreted under stress conditions may be a pathological factor that induces neuroinflammation.
TGFβ Treated Placenta Derived Mesenchymal Stem Cells Selectively Promote Anti-Adipogenesis in Thyroid-Associated Ophthalmopathy
Authors: Shin Hyun-Ah , Park Mira , Banga Jasvinder Paul , Lew Helen 
Published: March 2022

Abstract

Background
Thyroid-associated ophthalmopathy (TAO) includes several ocular manifestations of the systemic autoimmune process, Graves’ disease. The key pathogenic cells are orbital fibroblasts (OFs). The OFs of most TAO patients are differentiated from pre-adipocytes to mature adipocytes, increased lipid and fat expansion are characteristic of ophthalmic disease. Human placental mesenchymal stem cells (hPMSCs) immunomodulate the pathogenesis. We previous showed that hPMSCs were therapeutic. Here, we prepared transforming growth factor β (TGFβ) treated hPMSCs (TGFβ-hPMSCs) to enhance adipogenesis inhibition in vitro and TAO mice.
Methods
To investigate anti-adipogenic effects in vitro, primary OFs were grown in differentiation medium for 2, 4, and 10 days. After co-cultur with hPMSCs and TGFβ-hPMSCs, the OFs were analyzed via quantitative real-time polymerase chain reaction, Oil red O staining and western blotting. Human PMSCs and TGFβ-hPMSCs were injected into the left orbits of TAO mice. We explored the anti-adipogenic pathway in play using SB431542, a TGFβ receptor kinase inhibitor.
Results
TGFβ-hPMSCs suppressed trrancription of the adipogenic, lipogenic, and fibrotic genes PPARγ, C/EBPα, LEPTIN, AP2, SREBP2, HMGCR, α-SMA, FIBRONECTIN and IL-17 more so than did hPMSCs when adipogenesis-induced primary TAO OFs. Moreover, in TAO mice injected with TGFβ-hPMSCs, the adipose area was reduced compared to that after injection, of hPMSCs or a steroid, and the expression levels of the Pparγ and C/ebpα were more effectively suppressed. These anti-adipogenic effects were mediated by the SMAD 2 and SMAD3 pathways both in vitro and in vivo. TGFβ-hPMSCs inhibited inflammation as effectively as did a steroid both in vitro and in vivo, and reduced in vitro fibrosis.
Conclusion
TGFβ-hPMSCs reduced adipogenesis and lipogenesis in in vitro and TAO mice with experimental indicating that TGFβ-hPMSCs could serve as cellular therapy for TAO patients. Furthermore, TGFβ-hPMSCs exhibited anti-inflammatory and anti-fibrotic functions and thus, could be used to treat muscle fibrosis in TAO patients.
Phylogeny and taxonomy of Spongipellis (Meripilaceae. Basidiomycota) and its micromorphological similar genera in Cerrenaceae
Authors: Wang Chao-Ge , Dai Yu-Cheng 
Published: March 2022

Abstract
Phylogenetic and morphological analyses on Spongipellis and its micromorphological similar genera, Irpiciporus, Pseudospongipellis and Radulodon, were carried out. Phylogenies on Spongipellis are reconstructed with multiple loci DNA sequences including the internal transcribed spacer regions (ITS), the large subunit (nLSU) and the small subunit (nSSU) of nuclear ribosomal RNA gene and the translation elongation factor 1-α gene (TEF1). The results demonstrate the polyphyly of Spongipellis, including two genera belong to different families, Pseudospongipellis gen. nov. is established including three new combinations. Three new species, Irpiciporus sinuosus, Radulodon yunnanensis and Spongipellis quercicola spp. nov., are described and illustrated.