bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reusable Iron/Iron Oxide-based Nanoparticles Catalyzed Organic Reactions
Authors: Adak Laksmikanta , Kundu Debasish , Roy Keya , Saha Malay , Roy Anup 
Published: February 2022

ABSTRACT:The last decade has witnessed a remarkable progress in the field of nanoscience and nanotechnology. Nanoparticles have been extensively used in diverse areas, including medicine, sensor, and catalysis. The easy accessibility of nanoparticles (NPs) with different shapes, sizes and compositions has inspired researchers to investigate their applications in catalysis. Recently, magnetic nanoparticles, such as iron-based nanoparticles, have attracted much consideration due to their unique properties, such as superparamagnetism, greater surface area, surface-to-volume ratio, and easy separation methodology. They increase the competence of organic reactions in terms of activity, selectivity, yield, simplicity, and sustainability. In this review, we focus on the developments of iron/iron oxide-based nanoparticles-catalyzed organic reactions and some examples of magnetic iron oxide nanoparticles as carriers/support for the main catalyst in organic reactions. Owing to magnetic properties, these nanocatalysts can be easily recovered from the reaction mixture by an external magnet and reused for several runs without loss of catalytic activity. Iron-based nanoparticles are used in a wide range of catalytic processes and applications. Notable focus has been on the hydrogenation of alkenes and alkynes, and also the hydrogenation of nitroarenes to aniline. Other catalyzed organic reactions, such as hydroboration of aldehydes and ketones, oxidative dehydrogenation of N-heterocycles, azide-alkyne cycloaddition reactions, synthesis of various heterocyclic compounds, multicomponent reactions, and crosscoupling reactions for C–C and C–heteroatom bond formation have been covered.
Comparisons of Forecasting for Survival Outcome for Head and Neck
Squamous Cell Carcinoma by using Machine Learning Models based on
Multi-omics
Authors: Huang Daizheng , Mo Liying , Su Yuangang , Yuan Jianhui , Xiao Zhiwei , Zhang Ziyan , Lan Xiuwan 
Published: February 2022

Background:
Machine learning methods showed excellent predictive ability in a wide
range of fields. For the survival of head and neck squamous cell carcinoma (HNSC), its multi-omics
influence is crucial. This study attempts to establish a variety of machine learning multi-omics models
to predict the survival of HNSC and find the most suitable machine learning prediction method.

Method:
The HNSC clinical data and multi-omics data were downloaded from the TCGA database.
The important variables were screened by the LASSO algorithm. We used a total of 12 supervised
machine learning models to predict the outcome of HNSC survival and compared the results. In vitro
qPCR was performed to verify core genes predicted by the random forest algorithm.

Results:
For omics of HNSC, the results of the twelve models showed that the performance of multiomics
was better than each single-omic alone. Results were presented, which showed that the Bayesian
network(BN) model (area under the curve [AUC] 0.8250, F1 score=0.7917) and random forest(RF)
model (area under the curve [AUC] 0.8002,F1 score=0.7839) played good prediction performance in
HNSC multi-omics data. The results of in vitro qPCR were consistent with the RF algorithm.

Conclusion:
Machine learning methods could better forecast the survival outcome of HNSC. Meanwhile,
this study found that the BN model and the RF model were the most superior. Moreover, the
forecast result of multi-omics was better than single-omic alone in HNSC.
Micronutrient Fortification in Foods and Soy Milk, a Plant-based Milk
Substitute as a Candidate Vehicle
Authors: Goswami Tridib Kumar , De Baishakhi 
Published: February 2022

Background:
Food fortification is an effective intervention strategy to combat micronutrient
malnutrition, hidden hunger, and for improvement of public health and nutritional status.
Choice of a cost-effective, widely consumed, compatible, and stable candidate vehicle is essential
for successful fortification.

Objective:
This comprehensive review discusses the aspects of food fortification along with the
suitability of soy milk, a plant-based milk substitute, as a candidate vehicle for fortification.

Methods:
Literature mining was done in food research journals, Pubmed, Scopus to collect
adopted fortification strategies and preferred vehicles for fortification.

Results:
Soy milk is a popular health beverage, globally consumed and preferred amongst lactovegetarians,
and especially those with bovine milk allergy and lactose intolerance. This plantbased
milk alternative is enriched in polyunsaturated fatty acids, phytoestrogens, and isoflavones
along with different macro- and micronutrients. As a candidate vehicle, soy milk offers the advantage
of incorporating a wide range of fortificants, is widely consumed, stable, and is compatible
with fortificants.

Conclusion:
Successful implementation of the fortification strategy and its global scale-up need
to overcome different scientific and technological hurdles, socio-economic, ethical, and political
barriers, as well as legislative issues. Public-private, multi-stake holder and global partnerships,
boosting of small-scale food industries, and developing tie-ups with large scale industries, as
well as promoting public awareness regarding the need for fortification are other necessary requisites.
Nimbolide, a Neem Limonoid, Inhibits Angiogenesis in Breast Cancer by Abrogating Aldose Reductase Mediated IGF-1/PI3K/Akt Signalling
Authors: Nivetha Ramesh , Arvindh Soundararajan , Baba Abdul Basit , Gade Deepak Reddy , Gopal Gopisetty , K Chitrathara , Reddy Kallamadi Prathap , Reddy G. Bhanuprakash , Nagini Siddavaram 
Published: February 2022

Background & Objectives:The insulin/IGF-1R/PI3K/Akt signalling cascade is increasingly being linked to breast cancer development, with aldose reductase (AR) playing a key role in mediating the crosstalk between this pathway and angiogenesis. The current study was designed to investigate whether nimbolide, a neem limonoid, targets the oncogenic signaling network to prevent angiogenesis in breast cancer. Methods: Breast cancer cells (MCF-7, MDA-MB-231), EAhy926 endotheMethods:Breast cancer cells (MCF-7, MDA-MB-231), EAhy926 endothelial cells, MDA-MB-231 xenografted nude mice, and tumour tissues from breast cancer patients were used for the study. The expression of AR and key players in IGF-1/PI3K/Akt signaling and angiogenesis was evaluated by qRT-PCR, immunoblotting, and immunohistochemistry. Molecular docking and simulation, overexpression, and knockdown experiments were performed to determine whether nimbolide targets AR and IGF-1R.Results:Nimbolide inhibited AR with consequent blockade of the IGF-1/PI3K/Akt and /HIF-1alpha/VEGF signalling circuit by influencing the phosphorylation and intracellular localisation of key signaling molecules. The downregulation of DNMT-1, HDAC-6, miR-21, HOTAIR, and H19 with the upregulation of miR-148a/miR-152 indicated that nimbolide regulates AR and IGF-1/PI3K/Akt signaling via epigenetic modifications. Coadministration of nimbolide with metformin and the chemotherapeutic drugs tamoxifen/cisplatin displayed higher efficacy than single agents in inhibiting IGF-1/PI3K/Akt/AR signaling. Grade-wise increases in IGF-1R and AR expression in breast cancer tissues underscore their value as biomarkers of progression.Conclusions:This study provides evidence for the anticancer effects of nimbolide in cellular and mouse models of breast cancer besides providing leads for new drug combinations. It has also opened up avenues for investigating potential molecules such as AR for therapeutic targeting of cancer.
Does Heparin Affect 99mTc-MAA In Vitro Stability?
Authors: Scotognella Teresa , Lanni Valerio , Moresi Fabiana , Rizzo Alessio , Guarneri Andrea , Valenza Venanzio 
Published: February 2022

Introduction:
Pulmonary embolism (PE) can be diagnosed by perfusion lung scintigra-phy using human albumin macroaggregates labelled 99mTc (99mTc-MAA). When PE is suspected, subcutaneous Low Molecular Weight Heparin (LMWH) should be administered even before the results of the PE diagnostic flowchart. In our study, we aimed to evaluate a possible interaction (in vitro interference) between 99mTc-MAA and LMWH.

Materials and Methods:
The reconstitution of MAA kit was performed according to the manufac-turer's instruction. After labelling, we carried out the following preparations: a standard dose of 99mTc-MAA alone, as control; 99mTc-MAA and enoxaparin at different ratios. According to the manufacturer's instruction, the radiochemical purity was performed and evaluated immediately (T0), after 15 and 30 minutes after incubation (T15 and T30).

Results:
We compared the radiochemical purity of 99mTc-MAA with: (i) radiochemical purity of 99mTc-MAA and enoxaparin (11 ratio), (ii) radiochemical purity of 99mTc-MAA and enoxaparin (0.5 ratio), and (iii) radiochemical purity of 99mTc-MAA and enoxaparin (ratio 2). No significant differ-ences were found between all the measured parameters at each time point for each ratio. We also tested the stability of 99mTc-MAA in physiological conditions (at 37°C in PBS): the initial radio-chemical purity of 99mTc-MAA was 99.78%. The values of 99mTc-MAA radiochemical purity were high in all conditions of possible interaction with LMWH, with values ranging from 98.00% at T0 to 95% at T30.

Conclusion:
We found no statistically significant change in the in vitro stability of 99mTc-MAA in the presence of enoxaparin, excluding a possible direct interference. Future studies will be needed to check the 99mTc-MAA stability under physiological conditions.
Statistical Approach to Enhance α-Amylase Production from Bacillus
licheniformis and Purification of the Enzyme
Authors: Hiteshi Kalpana , Gupta Reena 
Published: February 2022

Background:
The most widely used thermostable enzymes are the amylases in the
starch industry. These are among the most important enzymes and are of great significance in present
day biotechnology.

Objective:
The main objective of the present study was to enhance α-amylase production from Bacillus
licheniformis using Response Surface Methodology (RSM) and the purification of the enzyme
to homogeneity.

Method:
Bacterial culture producing α-amylase isolated from hot spring (Himachal Pradesh) was
identified as Bacillus licheniformis using 16S rDNA gene sequencing (NCBI Accession No.:
KR340466). Medium components and physical culture parameters viz. pH, temperature, inoculum
size, peptone concentration and starch concentration were optimized using RSM. Among these five
factors, three factors (starch concentration, peptone concentration and inoculum size) had a positive
effect on amylase production. A 4.09-fold increase in the production of α-amylase from B.
licheniformis was achieved using RSM as compared to One Factor At a Time. The enzyme was purified
by using Diethylaminoethyl Cellulose column chromatography and subsequently by
Sephadex G-75 gel filtration chromatography.

Result:
A purification fold of 23.39 and a yield of 12.12% were observed. A single band of 33
kDa was obtained using Sodium Dodecyl Sulphate (SDS) and native-Poly Acrylamide Gel Electrophoresis
(PAGE), which indicated that the enzyme was purified to homogeneity and was a
monomer. The enzyme showed stability at 50 and 65°C temperatures and at alkaline pH.

Conclusion:
The stability of purified enzyme at high temperatures and alkaline pH suggested its
wide application in textile, detergent and paper industries.
Computed tomographic geometrical analysis of surgical treatments for equine recurrent laryngeal neuropathy
Authors: Tucker Michelle L. , Wilson David G. , Reinink Shawn K. , Carmalt James L. 
Published: February 2022

Abstract

OBJECTIVES
To characterize the 3-D geometry of the equine larynx replicating laryngeal hemiplegia and 4 surgical interventions by use of CT under steady-state airflow conditions. Secondly, to use fluid mechanic principles of flow through a constriction to establish the relationship between measured airflow geometries with impedance for each surgical procedure.

SAMPLE
10 cadaveric horse larynges.

PROCEDURES
While CT scans were performed, inhalation during exercise conditions was replicated for each of the following 5 conditions: laryngeal hemiplegia, left laryngoplasty with ventriculocordectomy, left laryngoplasty with ipsilateral ventriculocordectomy and arytenoid corniculectomy, corniculectomy, and partial arytenoidectomy for each larynx while CT scans were performed. Laryngeal impedance was calculated, and selected cross-sectional areas were measured along each larynx for each test. Measured areas and constriction characteristics were analyzed with respect to impedance using a multilevel, mixed-effects model.

RESULTS
Incident angle, entrance coefficient, outlet coefficient, friction coefficient, orifice thickness, and surgical procedure were significantly associated with upper airway impedance in the bivariable model. The multivariate model showed a significant influence of incident angle, entrance coefficient, and surgical procedure on impedance; however, the orifice thickness became nonsignificant within the model.

CLINICAL RELEVANCE
Laryngeal impedance was significantly associated with the entrance configuration for each procedure. This suggested that the equine upper airway, despite having a highly complex geometry, adheres to fluid dynamic principles applying to constrictions within pipe flow. These underlying flow characteristics may explain the clinical outcomes observed in some patients, and lead to areas of improvement in the treatment of obstructive upper airway disease in horses.
Analisis Pengaruh Kinerja Keuangan Terhadap Kemampuan Membayar Zakat
Authors: Harahap Ima Khoirunnisa , Harahap Darwis , Zein Aliman Syahuri 
Published: February 2022

Abstract Zakat is one of the social activities carried out by PT. Bank Syariah Mandiri and that must be paid when it reaches the nisab. The calculation of zakat funds issued is 2.5% of profit before tax. To determine the ability of banks to generate relative profits using the Ratio of Return on Assets (ROA) and Return on Equity (ROE). Based on data obtained from PT. Bank Syariah Mandiri percentage of ROA, ROE and Zakat fluctuated in 2008-2016, however, the increase in percentage that occurred in ROA and ROE was not always followed by an increase in zakat. This research was conducted to determine whether ROA and ROE affect the ability to pay zakat in PT. Bank Syariah Mandiri, either partially or simultaneously. This research data is a quantitative research. And the data analysis technique used multiple linear regression method using the SPSS version 22.00 computer program. The results of the research partially (t test) state that ROA has no effect on zakat. Meanwhile, ROE affects zakat. ROA and ROE influence on zakat. Keywords: ROA, ROE, Zakat
Strategi Direct Fundraising dengan Koin LAZISNU Padangsidimpuan
Authors: Sitompul Risna Hairani , Harahap Siti Berlian 
Published: February 2022

ABSTRACT Fundraising strategy is a strategy carried out by an institution to raise funds such as the strategy carried out by LAZISNU Padangsidimpuan City in increasing ZIS fund receipts, which is useful for knowing the implementation of fundraising at LAZISNU. This study uses a qualitative approach with the type of field research. Sources of data in the form of primary data and secondary data. Collecting data with the method of observation, interviews and documentation. The data analysis technique used descriptive analysis method. The data validity technique was using triangulation, namely source triangulation and method triangulation. The results showed that LAZISNU Padangsidimpuan City implemented several strategies to raise funds. The fundraising strategy implemented by LAZISNU Padangsidimpuan City uses 2 methods, namely Direct Fundraising and Indirect Fundraising. Direct Fundraising consists of several programs, namely Zakat Pickup Service, Personal ZIS, Direct Mail, Nusantara Coin Movement and LAZISNU Glass Box, while the Indirect Fundraising method is carried out with the Socialization program. Keywords : Fundraising, Zakat, LAZISNU ABSTRAK Strategi Fundraising merupakan strategi yang dilakukan oleh sebuah lembaga untuk menghimpun dana seperti strategi yang dilakukan oleh LAZISNU Kota Padangsidimpuan dalam meningkatkan penerimaan dana ZIS, yang berguna untuk mengetahui implementasi fundraising pada LAZISNU. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian lapangan (field research). Sumber data berupa data primer dan data sukunder. Pengumpulan data dengan metode observasi, wawancara dan dokumentasi. Teknik analisis data menggunakan metode analisis deskriptif. Teknik keabsahan data dengan menggunakan triangulasi yaitu triangulasi sumber dan triangulasi metode. Hasil penelitian diketahui bahwa LAZISNU Kota Padangsidimpuan menerapkan beberapa strategi guna menghimpun dana. Strategi fundraising yang diterapkan oleh LAZISNU Kota Padangsidimpuan menggunakan 2 metode yaitu Direct Fundraising dan Indirect Fundraising. Direct Fundraising terdiri atas beberapa program yaitu Layanan Jemput Zakat, Personal ZIS, Direct Mail, Gerakan Koin Nusantara dan Kotak Kaca LAZISNU, sedangkan untuk metode Indirect Fundraising dilakukan dengan program Sosialisasi. Kata Kunci : Fundraising, Zakat, LAZISNU
Jual Beli Bahan Bakar Premium Eceran
Authors: Yuliana Yuliana 
Published: February 2022

Abstract This research is motivated, because of the reduction in the quantity of retail premium perliter quantity. Phenomena based on field survey that there are some patterns of retail premium that become the background, namely retail premium sales pattern with the first pattern, retail premium sales with bottled patterns accompanied by prices, and retail premium sales with bottled patterns accompanied by a reduction in quantity. As for the formulation of the problem how to buy and sell retail premium fuel? This research aims to find out which muamalah is true or legitimate, in accordance with Islamic law based on the quran hadits, for the general public towards buying and selling retail premium fuel. This research is a qualitative research that is collecting data source from the subject under study. After conducting field research and getting conclusions using the qiyas method to explore syara’ law from what is concluded from the field. AbstrakPenelitian ini dilatarbelakangi, karena adanya pengurangan takaran kuantitas perliter premium eceran. Fenomena yang berdasarkan surve di lapangan bahwa ada beberapa pola premium eceran yang menjadi latar belakang yaitu pola penjualan premium eceran dengan pola pertamini, penjualan premium eceran dengan pola botolan disertai harga, dan penjualan premium eceran dengan pola botolan disertai pengurangan kuantitas. Adapun rumusan masalah bagaimana Jual Beli Bahan Bakar Premium Eceran? Penelitian ini bertujuan untuk mengetahui bermuamalah yang benar atau salah, sudah sesuai dengan syariat Islam berlandaskan al-Quran dan Hadis, bagi masyarakat umum terhadap jual beli bahan bakar minyak premium eceran. Penelitian ini merupakan penelitian kualitatif (field reseach) yaitu mengumpulkan data yang bersumber dari subjek yang diteliti. Setelah melakukan penelitian lapangan dan mendapatkan kesimpulan mengunakan metode qiyas untuk menggali hukum syara’ dari apa yang simpulkan dari lapangan.
Analisis Potensi Likuefaksi dengan Berbagai Metode Berdasarkan Data Cone Penetration Test pada Jalan Tol Seksi II Probolinggo – Banyuwangi
Authors: Aldzulfikar Ahmad Faris , Ikhya Ikhya , Pratiwi Desti Santi 
Published: February 2022

ABSTRAKKerusakan infrastruktur yang terjadi di Indonesia bukan hanya diakibatkan oleh beban dinamis gempa, namun juga dipengaruhi oleh respon tanah di bawahnya ketika gempa terjadi, salah satu contohonya adalah fenomena likuefaksi. Proyek Pembangunan Jalan Tol Probolinggo – Banyuwangi, Jawa Timur berada pada zona kerentanan likuefaksi sedang dan berada dekat dengan sesar Probolinggo yang memiliki pegerakan 0,2mm per tahun dan memiliki besar magnitudo 6.5 Mw. Penelitian ini dimaksudkan untuk mengukur potensi likuefaksi yang mungkin terjadi pada proyek pembangunan tol Probolinggo – Banyuwangi dengan menggunakan data Cone Penetration Test (CPT) berdasarkan metode analisis Shibata & Terapaksa, Robertson & Wride, Youd & Idriss, Juang et. al dan Idriss & Boulanger untuk mencari nilai rasio tegangan siklik (CSR) dan rasio tahanan siklik (CRR). Data pendukung lainnya pada analisis potensi likuefaksi ini adalah peta bahaya gempa 2017 dengan klasifikasi situs tanah lunak dan sedang. Hasil penelitian menunjukan bahwa jenis tanah yang terlikuefaksi adalah tanah pasir dan lanau kepasiran, jenis tanah ini sangat berpengaruh terhadap nilai CRR, sedangkan nilai CSR dipengaruhi oleh percepatan puncak gempa dan klasifikasi situs tanah.Kata kunci: gempa, likuefaksi, metode analisis, CSR, CRR, CPT, percepatan puncak ABSTRACTInfrastructure damages that have been found in Indonesia were not only caused by dynamic loads of earthquake, but also by the soil response underneath it while an earthquake occurs and one of it being a phenomenon called liquefaction. The project of Probolinggo-Banyuwangi Toll Road in East Java is within a moderate zone of liquefable soil, located near Probolinggo fault which is moving 0.2mm every year, and a magnitude of 6.5 Mw. This research estimated the liquefaction potential of this project with the soil data obtained by Cone Penetration Test, analyzed by using the method of Shibata & Terapaksa, Robertson & Wride, Youd & Idriss, Juang et. al and Idriss Boulanger, calculating the Cyclic Stress Ratio and Cyclic Resistance Ratio. This analysis of the potential of liquefaction used the map of earthquake in 2017 applied to soft and medium soil class. This research shows that the type of soil liquefied is sand soil and sandy silt soil. Both of these types gave a significant influence in calculating the CRR value, while the CSR value in influenced by the maximum acceleration of earthquake and the soil classification.Keywords: earthquake, liquefaction, analysis method, CSR, CRR, CPT, maximum acceleration
Pengaruh Variasi Arus GMAW pada Sambungan Pipa aja API 5L Grade B terhadap Sifat Mekanik dan Struktur Mikro
Authors: Adi Ganda Putra  , Pawawoi  
Published: February 2022

Proses pengelasan merupakan teknologi penyambungan pada logam yang sering digunakan. Metoda pengelasan GMAW telah banyak digunakan secara luas pada penyambungan pipa penyalur (pipe line), pipa kostruksi, proses pemipaan (piping process), dll. Baja API 5L Grade B adalah salah satu bahan yang distandarkan oleh API untuk penggunaan/aplikasi perpipaan pada perusahaan minyak dan gas (oil and Gas). Dalam instalasinya dibutuhkan hasil penyambungan yang baik tanpa terbentuknya cacat pada sambungan sesuai dengan standar API. Variasi arus (100, 135 dan 160A) pada proses pengelasan GMAW akan berpengaruh terhadap heat input dan kelarutan (dilution) antara logam dasar dengan logam pengisi yang dapat menyebabkan perubahan sifat fisik dan sifat mekanik pada sambungan pipa.
Kualitas/mutu sambungan dapat dikaji dengan melakukan pengujian supaya dapat diketahui sifat fisik dan sifat mekanik hasil sambungan pipa dengan variasi arus pada metoda GMAW. Metoda pengujian yang dilakukan antara lain : uji tarik, uji nick break dan uji lengkung, sedangkan perubahan struktur mikro dikaji dengan analisa metalografi.