bluuebunny/crossref_metadata_2025_split huggingface dataset:
Verordnungsverhalten von bayerischen Hausärzt*innen an der stationär-ambulanten Schnittstelle vor dem Hintergrund der Bayerischen Wirkstoffvereinbarung – Qualitative Ergebnisse der WirtMed-Studie
Authors: Zeschick Nikoletta , Gollnick Julia , Muth Julia , Hörbrand Franziska , Killian Peter , Krombholz Wolfgang , Donner-Banzhoff Norbert , Kühlein Thomas , Sebastião Maria 
Published: July 2022

Zusammenfassung
Hintergrund und Ziel
Zur transparenten Steuerung der Arzneimittelausgaben im Rahmen des Wirtschaftlichkeitsgebots (§ 12 Fünftes Buch Sozialgesetzbuch (SGB V)) hat die Kassenärztliche Vereinigung Bayerns im Jahr 2014 die Wirkstoffvereinbarung (WSV) eingeführt. Diese hat die Richtgrößensystematik abgelöst. Mit Bezug auf die Rolle der WSV werden im Artikel die Gründe der Hausärzt*innen (HÄ) für oder gegen eine Weiterverordnung von Arzneimitteln aus dem Krankenhaus beschrieben.

Material und Methode
In einem qualitativen Studiendesign wurden im Zeitraum 11/2019 bis 03/2020 mit bayerischen HÄ Einzelinterviews (n = 18) und 2 Fokusgruppen (n = 10) durchgeführt und nach der qualitativen Inhaltsanalyse ausgewertet.

Ergebnisse
Mit der Einführung der WSV nahmen die Regresssorgen der HÄ insgesamt ab. Große Bedeutung bei Verordnungen haben – vor der Wirtschaftlichkeit – die patient*innenorientierte Versorgung und fachliche Richtigkeit von Therapieentscheidungen. Mit der Entlassmedikation ergeben sich wirtschaftliche Herausforderungen, besonders mit dem Leitsubstanzziel der oralen Antikoagulation, den Generikazielen bei Antidiabetika und bei Therapeutika für das Herz-Kreislauf-System. Allgemein kritisiert werden Rabattverträge, die oft zu Umstellungen von Arzneimitteln führen. Vereinzelt wird von einer „Vormachtstellung“ der Klinikärzt*innen berichtet, die dem hausärztlichen wirtschaftlichen Handeln entgegenstehen. Es fehlt laut HÄ eine sektorenübergreifende Kostenverantwortung.

Diskussion
Ein reibungsloser Schnittstellenübergang ist aus Sicht der HÄ trotz des Rahmenvertrags Entlassmanagement und der neuen Steuerungssystematik der WSV im ambulanten Sektor noch nicht vorhanden. Für eine wirtschaftliche Arzneimittelversorgung bedarf es weiterhin einer sektorenübergreifenden, aber auch bundesländerübergreifenden politischen Diskussion.
Cut-off values for diagnosis of G6PD deficiency by flow cytometry in Thai population
Authors: Thedsawad Anchalee , Wanachiwanawin Wanchai , Taka Orathai , Hantaweepant Chattree 
Published: July 2022

AbstractIn heterozygous females, X-inactivation causes a change in glucose-6-phosphate dehydrogenase (G6PD) activity from normal to deficient. Most G6PD screening tests are used to accurately diagnose hemizygous males, but they are less reliable for diagnosing heterozygous females. This study established flow cytometric cut-off values for screening of G6PD deficiency in hemizygous males and heterozygous or homozygous females. We studied 205 (125 females, 80 males) leftover blood samples from quantitative methemoglobin reduction (MR) screening. G6PD gene mutations determined by multiplex amplification refractory mutation system-polymerase chain reaction and direct DNA sequencing were used as the gold standard reference. Accuracy of the test, including the sensitivity, specificity, and positive and negative predictive values, was analyzed using MedCalc software. The optimal cut-off values for classification of %red blood cells with normal G6PD activity or %bright cells into homozygous normal, heterozygous, and homozygous deficiency in females were 85.4–100%, 6.3–85.3%, and 0–6.2%, respectively (sensitivity 93.2%, specificity 100%). The cut-offs for classification into hemizygous normal and hemizygous deficiency in males were 76.5–100% and 0–76.4%, respectively (sensitivity 100%, specificity 96.5%). Flow cytometry can be used to differentiate heterozygous females with intermediate phenotype from homozygous females, but cannot distinguish between heterozygous females with extreme phenotype and homozygous females. By flow cytometry, heterozygous and homozygous deficiency was detected in 29.6% and 3.2% of females, respectively. Among males, hemizygous deficiency was found in 31.3%. Flow cytometry can be used to screen patients with G6PD deficiency, and reliably and efficiently identify heterozygous and homozygous females, and hemizygous males based on cellular G6PD activity.
The impact of bicuspid aortic valve morphology on von Willebrand factor function in patients with severe aortic stenosis and its change after TAVI
Authors: Roth Nastasia , Heidel Carolin , Xu Congde , Hubauer Ute , Wallner Stefan , Meindl Christine , Holzamer Andreas , Hilker Michael , Creutzenberg Marcus , Sossalla Samuel , Maier Lars , Jungbauer Carsten , Debl Kurt 
Published: July 2022

Abstract
Background
Aortic stenosis (AS) can cause acquired von Willebrand syndrome (AVWS) and valve replacement has been shown to lead to von Willebrand factor (vWF) recovery. The aim of the current study was to investigate the prevalence of AVWS in different severe AS phenotypes and its course after transcatheter aortic valve implantation (TAVI).

Methods
143 patients with severe AS undergoing TAVI were included in the study. vWF function was assessed at baseline, 6 and 24 h after TAVI. AVWS was defined as a reduced vWF:Ac/Ag ratio ≤ 0.7. Phenotypes were classified by tricuspid (TAV) and bicuspid (BAV) valve morphology, mean transvalvular gradient (Pmean), stroke volume index (SVI), ejection fraction (EF) and indexed effective orifice area (iEOA).

Results
AVWS was present in 36 (25.2%) patients before TAVI. vWF:Ac/Ag ratio was significantly lower in high gradient compared to low-gradient severe AS [0.78 (IQR 0.67–0.86) vs. 0.83 (IQR 0.74–0.93), p < 0.05] and in patients with BAV compared to TAV [0.70 (IQR 0.63–0.78) vs. 0.81 (IQR 0.71–0.89), p < 0.05]. Normalization of vWF:Ac/Ag ratio was achieved in 61% patients 24 h after TAVI. As in the overall study cohort, vWF:Ac/Ag ratio increased significantly in all severe AS subgroups 6 h after TAVI (each p < 0.05). Regarding binary logistic regression analysis, BAV was the only significant predictor for AVWS.

Conclusions
BAV morphology is a strong predictor for AVWS in severe AS. TAVI restores vWF function in most patients with severe AS independently of AS phenotype and valve morphology.

Graphical abstract
Awareness, offer, and use of psychosocial services by breast cancer survivors in Germany: a prospective multi-centre study
Authors: Singer Susanne , Janni Wolfgang , Kühn Thorsten , Flock Felix , Felberbaum Ricardo , Schwentner Lukas , Leinert Elena , Wöckel Achim , Schlaiß Tanja ,   for the BRENDA study group
Published: July 2022

Abstract
Purpose
This study examined the pattern of psychosocial care in breast cancer survivors.

Methods
In a prospective study with measurements before surgery, 1 month, 8 months, and 5 years thereafter, we examined the proportion of breast cancer survivors who were aware about, had been offered and received various types of psychosocial services from psychologists, social workers, doctors, self-help groups etc. The degree of helpfulness per service among users was ascertained with Likert scales. Determinants of awareness, offer and use were investigated using binary logistic regression analyses. How the services are inter-related was tested with principal component analyses.

Results
Among 456 breast cancer survivors who participated until 5 years, psychological services were known by 91%, offered to 68%, and used by 55% of patients. Social services were known by 86%, offered to 65%, and used by 51%. Women ≥ 65 years were less likely to be informed about (odds ratio (OR) 0.2) and get offers for psychosocial services (OR 0.4 for social and 0.5 for psychological services) than women < 65 years. The services rated most helpful were social services in the hospital, psychological counselling by a consultant and psychotherapy in private practices.

Conclusion
These findings underline the importance of psychosocial support by physicians in addition to the "professional" mental health and social care providers. They also show that elderly women in need for support might be in danger of not being well-informed about the services available.
Evaluations of heat action plans for reducing the health impacts of extreme heat: methodological developments (2012–2021) and remaining challenges
Authors: Dwyer Ian J. , Barry Sarah J. E. , Megiddo Itamar , White Christopher J. 
Published: July 2022

Abstract
The recent report of the Intergovernmental Panel on Climate Change is stark in its warnings about the changing climate, including future increases in the frequency and intensity of extremely hot weather. The well-established impacts of extreme heat on human health have led to widespread implementation of national and city-wide heat plans for mitigating such impacts. Evaluations of the effectiveness of some heat plans have been published, with previous reviews highlighting key methodological challenges. This article reviews methods used since and that address those challenges, so helping to set an agenda for improving evaluations of heat plans in terms of their effectiveness in reducing heat-health impacts. We examined the reviews that identified the methodological challenges and systematically searched the literature to find evaluations that had since been conducted. We found 11 evaluations. Their methods help address the key challenge of identifying study control groups and address other challenges to a limited extent. For future evaluations, we recommend: utilising recent evaluation methodologies, such as difference-in-differences quasi-experimental designs where appropriate; cross-agency working to utilise data on morbidity and confounders; adoption of a proposed universal heat index; and greater publication of evaluations. More evaluations should assess morbidity outcomes and be conducted in low- and middle-income countries. Evaluations of heat plans globally should employ robust methodologies, as demonstrated in existing studies and potentially transferrable from other fields. Publication of such evaluations will advance the field and thus help address some of the health challenges resulting from our changing climate.
Deep learning for volatility forecasting in asset management
Authors: Petrozziello Alessio , Troiano Luigi , Serra Angela , Jordanov Ivan , Storti Giuseppe , Tagliaferri Roberto , La Rocca Michele 
Published: July 2022

AbstractPredicting volatility is a critical activity for taking risk- adjusted decisions in asset trading and allocation. In order to provide effective decision-making support, in this paper we investigate the profitability of a deep Long Short-Term Memory (LSTM) Neural Network for forecasting daily stock market volatility using a panel of 28 assets representative of the Dow Jones Industrial Average index combined with the market factor proxied by the SPY and, separately, a panel of 92 assets belonging to the NASDAQ 100 index. The Dow Jones plus SPY data are from January 2002 to August 2008, while the NASDAQ 100 is from December 2012 to November 2017. If, on the one hand, we expect that this evolutionary behavior can be effectively captured adaptively through the use of Artificial Intelligence (AI) flexible methods, on the other, in this setting, standard parametric approaches could fail to provide optimal predictions. We compared the volatility forecasts generated by the LSTM approach to those obtained through use of widely recognized benchmarks models in this field, in particular, univariate parametric models such as the Realized Generalized Autoregressive Conditionally Heteroskedastic (R-GARCH) and the Glosten–Jagannathan–Runkle Multiplicative Error Models (GJR-MEM). The results demonstrate the superiority of the LSTM over the widely popular R-GARCH and GJR-MEM univariate parametric methods, when forecasting in condition of high volatility, while still producing comparable predictions for more tranquil periods.
Bilateral comparison of primary reference materials (PRMs) containing methanol, ethanol and acetone in nitrogen
Authors: Worton D. R. , Moreno S. , Brewer P. J. , Li J. , Baldan A. , van der Veen A. M. H. 
Published: July 2022

AbstractA range of oxygenated volatile organic compounds (OVOCs) are present in the atmosphere as a result of direct emissions and as products of atmospheric oxidation. Long-term measurements are important to understand changes to these emission sources and atmospheric oxidation processes. Accurate and stable traceable gaseous primary reference materials are needed to underpin rigorous quality assurance and quality control at monitoring stations such as those organised by the World Meteorological Organization Global Atmosphere Watch (WMO-GAW) programme. The development of a capability for providing traceable primary reference materials (PRMs) of OVOCs is of paramount importance due to the increasing prevalence of these compounds in the urban atmosphere and also because there is currently no Central Calibration Laboratory (CCL) for these components within the WMO-GAW programme. This EURAMET bilateral comparison demonstrates the measurement compatibility (≤ 3%) for three OVOCs (methanol, ethanol and acetone) at nominally 5 µmol mol−1 between two National Metrology Institutes: the National Physical Laboratory (NPL), UK and the Van Swinden Laboratorium (VSL), the Netherlands. The comparison shows that a gravimetric method for value assignment is applicable to acetone but that a more complicated procedure must be employed to value assign methanol and ethanol due to corrections for adsorption effects, which can be as large as 10 % of the nominal value. This work demonstrates the importance of making appropriate corrections to ensure the accuracy of these reference materials. NPL and VSL used different approaches to make these corrections providing confidence and independent verification. This work supports new calibration and measurement capabilities for methanol, ethanol and acetone in the range of 1 μmol mol−1 –10 μmol mol−1 with expanded uncertainties of 6.9 % (3 %), 7.3 % (3 %) and 1.7 % (2 %) for NPL (VSL), respectively, to be realized in the key comparison database and supports the development of the required traceability infrastructure to underpin long-term global measurements of these OVOCs.
Effect of microbial-induced calcite precipitation towards strength and permeability of peat
Authors: Phang Ignatius Ren Kai , Wong Kwong Soon , Chan Yen San , Lau Sie Yon 
Published: July 2022

AbstractPeat is known as problematic ground with low bearing capacity and extensively high compressibility. Bio-cementation or commonly known as microbial-induced calcite precipitation (MICP) has been recently introduced as a ground improvement alternative for peat under waterlogged condition. Using isolated bacteria strains P19 and P21 from tropical peat, it is found that unconfined compression strength (UCS) increases with bacteria concentration at a reducing rate. A maximum unconfined compressive strength of 82.05 kPa was measured with bacteria strain P21 at 108 CFU/mL. For the range of cementation reagent varying from 0.1 to 4.0 mol/kg, the largest strength improvement occurred at 1 mol/kg and 2 mol/kg using indigenous bacteria and bacteria strain P21, respectively, for peat with sand content of 25%. At 4.0 mol/kg, the cementation reagent has detrimental effect to MICP resulting in significant reduction in strength. Due to MICP, the UCS of peat increases with sand content. Calcium carbonate precipitation results in a reduction of permeability and an increment of strength of peat–sand mixture under a submerged condition up to 28 days.
Do Couple-Based Interventions Show Larger Effects in Promoting HIV Preventive Behaviors than Individualized Interventions in Couples? A Systematic Review and Meta-analysis of 11 Randomized Controlled Trials
Authors: Fu Rong , Hou Jianhua , Gu Yuzhou , Yu Nancy Xiaonan 
Published: July 2022

AbstractThis systematic review and meta-analysis aims to compare the effects of couple-based prevention interventions against individual-level interventions on HIV prevention in randomized controlled trials (RCTs), identify potential moderators, and assess study quality. Eleven RCTs were included, comprising 3933 couples in the intervention group and 7125 individuals in the individual control group, predominantly in heterosexual couples from the USA and Africa. Couple-based interventions had a more significant effect in promoting condom use and HIV testing. Education levels of high school or above, residence in low- and middle-income countries, and intervention design incorporating HIV counseling and testing were associated with higher odds of condom use. The quality assessment analysis identified methodological and theoretical heterogeneity factors. Evidence of couple-based HIV prevention RCTs among men who have sex with men, injecting drug users, sex workers, and transgender women warrant further investigation. Recommendations are made to improve the quality and replicability of future intervention studies.
On identifying risk-adjusted efficiency gains or losses of prospective mergers and acquisitions
Authors: Tsionas Mike G. , Baltas Konstantinos N. 
Published: July 2022

AbstractWe propose a new approach to evaluate and compare ex-ante the risk-adjusted efficiency gains or losses of potential mergers and acquisitions (M &A). We test our methodology in the banking sector by estimating a latent class stochastic frontier model to account for the unobserved heterogeneity. We show that post-prospective M &A financial institutions can be better equipped to withstand potential adverse economic conditions. We highlight that similarities in strategic characteristics are vital in the creation of post-consolidation cost efficiency surplus. Our results are consistent after various robustness tests. Our findings have important policy implications in light of the challenges the traditional banking business model faces in the current digitalisation era.
Leadership and Workplace Aggression: A Meta-analysis
Authors: Cao Wenrui , Li Peikai , C. van der Wal Reine , W. Taris Toon 
Published: July 2022

AbstractWorkplace aggression (bullying, incivility, and similar forms of interpersonal mistreatment) has been established as a prevalent and detrimental issue in organizations. While numerous studies have documented the important role of leaders in inhibiting or accelerating workplace aggression, a systematic overview of the associations between different leadership styles and workplace aggression as well as its boundary conditions is still lacking. This study reports a meta-analysis investigating the associations between leadership and workplace aggression. Drawing on data from 165 samples (N = 115,190), our results revealed that change-oriented, relational-oriented, and values-based and moral leadership (but not task-oriented leadership) were associated with reduced workplace aggression. In contrast, passive and destructive leadership (i.e., abusive, narcissistic, uncivil, and authoritarian) were associated with increased workplace aggression. Importantly, relative weights analyses revealed that ethical leadership was most strongly negatively associated with workplace aggression. Additionally, moderation analyses revealed that the associations between leadership and workplace aggression were, in some cases, moderated by power distance (for transactional leadership) and rating sources (for transformational and abusive supervision), but independent of measurement time lag. Overall, the findings of this meta-analysis highlight the important associations between leadership and workplace aggression. Implications for future research and policy recommendations aiming to reduce workplace aggression are discussed.
Determinants of Supply Chain Engagement in Carbon Management
Authors: Lintukangas Katrina , Arminen Heli , Kähkönen Anni-Kaisa , Karttunen Elina 
Published: July 2022

AbstractTo fight climate change, firms must adopt effective and feasible carbon management practices that promote collaboration within supply chains. Engaging suppliers and customers on carbon management reduces vulnerability to climate-related risks and increases resilience and adaptability in supply chains. Therefore, it is important to understand the motives and preconditions for pursuing supply chain engagement from companies that actively engage with supply chain members in carbon management. In this study, a relational view is applied to operationalize the supply chain engagement concept to reflect the different levels of supplier and customer engagement. Based on a sample of 345 companies from the Carbon Disclosure Project’s supply chain program, the determinants of engagement were hypothesized and tested using multinomial and ordinal logistic estimation methods. The results indicate that companies that integrate climate change into their strategies and are involved in developing environmental public policy are driven by moral motives to engage their suppliers and customers in carbon management. All these factors make a stronger impact on supplier engagement than on customer engagement. Moreover, companies operating in greenhouse gas-intensive industries are driven by instrumental motives to engage their suppliers and customers because increasing greenhouse gas intensity positively influences engagement level. Company profitability appears to increase supplier engagement, but not customer engagement. Interestingly, operating in a country with stringent environmental regulations does not appear to influence supply chain engagement. By utilizing relational capabilities and collaboration, buyers can increase their suppliers’ engagement to disclose emissions, which ultimately will lead to better results in carbon management.
A product space reformulation with reduced dimension for splitting algorithms
Authors: Campoy Rubén 
Published: July 2022

AbstractIn this paper we propose a product space reformulation to transform monotone inclusions described by finitely many operators on a Hilbert space into equivalent two-operator problems. Our approach relies on Pierra’s classical reformulation with a different decomposition, which results in a reduction of the dimension of the outcoming product Hilbert space. We discuss the case of not necessarily convex feasibility and best approximation problems. By applying existing splitting methods to the proposed reformulation we obtain new parallel variants of them with a reduction in the number of variables. The convergence of the new algorithms is straightforwardly derived with no further assumptions. The computational advantage is illustrated through some numerical experiments.
Heavy metals and parasitological infection associated with oxidative stress and histopathological alteration in the Clarias gariepinus
Authors: EL-Hak Heba N. Gad , Ghobashy Mahi A. , Mansour Farida A. , El-Shenawy Nahla S. , El-Din Marwa I. Saad 
Published: July 2022

AbstractThe goal of this study was to assess the harmful effects of heavy metal accumulation onClarias gariepinus(catfish) in two different polluted areas in the Al Sharkia governorate and assess the impact on oxidative stress and histological changes. The results revealed a highly significant difference in heavy metal levels in the water and inside fish tissues (liver and gonads) between the two sites. The total prevalence of parasitic infection was at the highest percentage in area B, in addition to severe histopathological damage to the liver and the gonads. Findings show that the total prevalence of parasitic infection is associated with uptake of metals, depleted antioxidant activity, and incidence of lipid peroxidation in tissue.