bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-breast carcinoma effects of green synthesized nickel nanoparticles from Alhagi ‎sparsifolia leaf aqueous extract: A pre-clinical trial study ‎
Authors: Ren Qingquan , Goorani Samaneh , Mahdavi Behnam , Rashidi Khodabakhsh , Zangeneh Mohammad Mahdi 
Published: January 2022

IntroductionMany nanoparticles have pharmacological and biochemical properties, including antioxidant and anti-‎inflammatory properties, which appear to be involved in anticarcinogenic and antimutagenic activities. In the recent study, nickel nanoparticles were green-synthesized using the Alhagi sparsifolia leaf aqueous ‎extract. ‎Material and methodsThe synthesized Ni nanoparticles‎ were characterized by analytical techniques including SEM, UV-Vis., and FT-‎IR. The nanoparticles were formed in a spherical shape in the average size of 16.19 nm. ‎ResultsIn the antioxidant test, the IC50 of Ni nanoparticles‎ and BHT against DPPH free radicals were 316 and 231 ‎‎µg/mL, respectively. In the cellular and molecular part of the recent study, the treated cells with Ni ‎nanoparticles‎ were assessed by MTT assay for 48h about the cytotoxicity and anti-human breast cancer ‎properties on normal (HUVEC) and breast cancer cell lines i.e. lobular carcinoma of breast (UACC-3133), ‎inflammatory carcinoma of the breast (UACC-732), and metastatic carcinoma (MDA-MB-453). The viability of ‎malignant breast cell line reduced dose-dependently in the presence of Ni nanoparticles‎. The IC50 of Ni ‎nanoparticles‎ were 477, 548, and 605 µg/mL against lobular carcinoma of breast (UACC-3133), inflammatory ‎carcinoma of the breast (UACC-732), and metastatic carcinoma (MDA-MB-453) cell lines, respectively. ‎ConclusionsAfter clinical study, nickel nanoparticles containing Alhagi sparsifolia leaf aqueous extract may be used to ‎formulate a new chemotherapeutic drug or supplement to treat the several types of human breast cancer. ‎
Model Pembelajaran Kooperatif “Dapil Tebu Itam” untuk Meningkatkan Kemampuan Menulis Naskah Drama
Authors: Purwaningtyas Handri 
Published: January 2022

Penelitian ini bertujuan untuk mengetahui peningkatan kemampuan menulis naskah drama siswa kelas XI SMAN 1 Banguntapan dengan menggunakan model pembelajaran Kooperatif “Dapil Tebu Itam”. Metode penelitian yang digunakan adalah penelitian tindakan kelas atau classroom action research. Penelitian dilaksana kandalam dua siklus, tiap siklus dilaksanakan dua kali tatap muka. Semua siklus menerapkan model pembelajaran Kooperatif “Dapil Tebu Itam” dengan berbagai variasi kegiatan. Subjek penelitiannya adalah siswa kelas XI IPS 1 SMA Negeri 1 Banguntapan, sedangkan objeknya adalah kemampuan menulisnaskah drama. Data dan instrument dalam penelitian ini adalah instrumen penilaian kemampuan menulis naskah drama siswa dan instrumen observasi keaktifan siswa. Teknik analisis data dalam penelitian ini menggunakan analisis deskriptif kualitatif. Berdasarkan hasil penelitian dapat diambil kesimpulan bahwa dengan menerapkan model pembelajaran Kooperatif “Dapil Tebu Itam” kemampuan siswa dalam menulis naskah drama meningkat. Hal ini dibuktikan oleh data sebagai berikut: (1) Sebelum diberikan tindakan hasil nilai rerata kelas menunjukkan hasil yang rendah, yaitu hanya 50% siswa yang nilainya mencapai KKM 76.00, sedangkan 50% lainnya di bawah KKM; (2) Setelah dilakukan tindakan pada siklus pertama nilai rerata kelas meningkat, siswa yang berhasil mencapai KKM sebanyak 62,5%, sedangkan siswa yang nilainya belum KKM 37%. (3) Pada siklus kedua, nilai siswa yang sudah mencapai KKM meningkat menjadi 100%.
Blended Learning sebagai Model Pembelajaran Abad 21
Authors: Puspitarini Dyah 
Published: January 2022

Tulisan ini bertujuan mendeskripsikan perkembangan paradigma pembelajaran, konsep pembelajaran berbasis teknologi, dan penerapan blended learning sebagai model pembelajaran abad 21. Proses pembelajaran tak luput dari sentuhan teknologi, khususnya yang berbasis internet. Peserta didik saat ini merupakan generasi milenial dan generasi Z yang sangat akrab dengan teknologi informasi dan komunikasi. Oleh karena itu guru harus mampu menyesuaikan diri dengan karakteristik peserta didik milenial, sehingga tidak bisa lagi mengajar dengan strategi pembelajaran yang standar dan biasa-biasa saja. Guru harus kreatif, mengembangkan beragam strategi, metode, dan model pembelajaran untuk menyajikan kegiatan pembelajaran yang menarik, juga harus mampu memanfaatkan e-learning sebagai alternatif pembelajaran. Namun, baik pembelajaran tatap muka maupun e-learning masing-masing memiliki kelemahan. Blended learning yang memadukan kelebihan pembelajaran tatap muka dan e-learning merupakan pilihan yang tepat. Dalam pembelajaran blended, guru memanfaatkan teknologi informasi dan komunikasi, tetapi tetap dapat ‘bersentuhan’ dengan peserta didik melalui pembelajaran tatap muka. Blended learning mengombinasikan beberapa strategi pembelajaran yaitu kegiatan tatap muka, pembelajaran berbasis komputer secara offline, dan komputer secara online. Blended learning dapat diterapkan tanpa batasan khusus berapa prosentasi tatap muka dan penggunaan teknologi komputer atau internet, dilakukan secara sinkronius atau asinkronius. Dalam merancang desain pembelajaran guru dapat menentukan prosentase pemanfaatan internet baik secara online maupun offline. Hasil dari proses pembelajaran blended learning efektif karena mampu mengatasi kelemahan model pembelajaran tatap muka yang didominasi guru, sekaligus kelemahan pembelajaran secara e-learning yang hanya mengandalkan teknologi komunikasi.
Interaksi Sosial Mahasiswa Pendidikan Jasmani, Kesehatan dan Rekreasi (PJKR) FKIP Universitas Palangka Raya di Masa Pandemi Covid-19
Authors: Mikdar Mikdar , Ulfa Zuly Daima , Abeng Andi Tenri 
Published: January 2022

Pandemic covid-19 has an impact in the implementation of daily activities including on students. Social distancing is carried out in order to prevent the transmission of covid-19. Outdoor activities are restricted, requiring adjustments including social interactions. This study aims to identify the social interaction of students of Physical Education, Health and Recreation (PJKR) FKIP University of Palangka Raya during the covid-19 pandemic.
Research is a survey with a crosssectional approach in students PJKR study program, FKIP University of Palangka Raya, as many as 115 people. Sampling technique used is simple random sampling. Online data collection using questionnaires through google form.
Social interaction between students related to assignments and lecture activities (88%), communication outside campus activities (45%), student and extracurricular activities (34%), hobbies and achievements (33%). While the social interaction of students with lecturers related to lecture materials (91%), lecture assignments (64%), academic guidance activities (20%), off-campus activities (14%) and other interactions. Changes in social interaction in the form of interactions become limited, online communication increases including the utilization of social media as well as increased use of mobile phones and other devices. Advice should be considered concern about lecture activities that involve social interaction between students, students with lecturers and students with the community and the use of technology while maintaining the prevailing social values in the community.
A two-parameter model for the determination of the partition coefficient for TRS in a culture medium
Authors: Silva Javier , Ortiz Rodrigo , Carrasco Samuel , Aroca German 
Published: January 2022

A two-parameters model was applied for the determination of the activity coefficient for a culture medium, and compared with Henry's law, the extended UNIQUAC, and experimental data obtained from an experimental setup system, consisting of a liquid culture media Thiobacillus (ATCC 290) with hydrogen sulfide (H2S), dimethyl sulfide (DMS), methyl mercaptan (MM), and dimethyl disulfide (DMDS), respectively.
The ANOVA indicates that the use of Henry's law is not appropriate for MM and H2S with R2adj values of -106.15% and -53.33%, respectively. The extended UNIQUAC model and the two-parameter model were able to describe the system with values of 76.94% and 94.15% for DMS and DMDS in the case of UNIQUAC Extended, respectively, and 88.50% and 98.08% using the two-parameter model.

These results show that the two-parameter model is able to describe the system, using a low number of parameters. However, the extended UNIQUAC shows better results but presenting a high level of over-parameterization. Henry's law showed significant deviations, not being representative of all analyzed cases.
The two-parameter model is presented as an alternative to describing systems in which vapor-liquid mass transfer is involved in culture media, providing a better approximation than traditional models and lower calculation costs than complex models.
EFFECT OF USING RESISTANT STARCH ON GLYCEMIC INDEX AND RHEOLOGICAL PROPERTIES OF MILKY PUDDING
Authors: Bekiroglu H. , Komurlu E. , Cebi Nur , Sagdic O. 
Published: January 2022

In this study, resistant starch (RS)-enriched pudding production was performed in order to develop puddings with reduced glycemic index which could be consumed as functional milky dessert to cope with obesity and high blood sugar. Control sample without the resistant starch (RS) and three pudding samples with RS (1%, 2% and 3%) were prepared. Physical analyzes of the samples were performed, their sensory and rheological properties were examined and glycemic index analyzes were implemented in vitro conditions. With the addition of RS, the moisture content of the puddings decreased and there was an increase in L* value. The rheological properties of pudding samples were evaluated using a rheometer. Results showed that, the viscosities of the RS added samples were lower when compared to to the control sample. The glycemic index value decreased with the increase in the RS content of puddings. Sensory analysis test was performed to a group consisting of 10 panelists. 3% RS sample was determined to be more favorable. Analyzes showed that RS caused positive effects on pudding moisture, brightness, rheology and glycemic index. As a result of this study, it was found that the sample containing 3% RS had acceptable and favorable properties.
POLÍTICAS PÚBLICAS DE SAÚDE À POPULAÇÃO LGBT: UM OLHAR NAS AÇÕES DE SAÚDE POR MEIO DA MULTIDISCIPLINARIDADE
Authors: Alves Macedo João Paulo , Santos Moreira Morais Cintia , Lima Galeano Luana , Aparecida Xavier Moreira da Silva Maria , Santana Santos Gisele 
Published: January 2022

O direito à saúde é considerado universal, resultante de uma grande mobilização política da sociedade. Historicamente a população LGBT sofre preconceitos e têm seus direitos fundamentais violados. Devido a esse fator, o acesso dessa população aos serviços de saúde se torna fraco e sensível, contribuindo para uma piora no estado de saúde do indivíduo. Este estudo se justifica no entendimento de que é necessário que haja o desenvolvimento de ações e estratégias de saúde que possam promover a integralidade, a equidade e a universalidade da atenção à saúde da pessoa LGBT. O objetivo geral desse estudo é descrever as ações e estratégias de saúde para o atendimento específico das pessoas LGBT, com foco na multidisciplinaridade. Trata-se de uma pesquisa descritiva, transversal com abordagem qualitativa, que foi realizada com graduandos dos cursos da área da saúde de uma instituição de ensino superior (IES) situada em um município da grande São Paulo. Embora tenha sido perceptível que a ausência da abordagem dessa temática nos cursos de enfermagem, nutrição, fisioterapia e psicologia, os graduandos descreveram ações e estratégias para a atenção à saúde da população LGBT, levando em consideração os preceitos dos direitos humanos, a integralidade, equidade e universalidade, no campo de suas áreas de conhecimento e da multidisciplinaridade.
Managing in early COVID-19: The Nigerian optometry experience
Authors: Musa Mutali , Okoye Godwin S. , Akpalaba Raphael U. E. , Atuanya George Nnamdi 
Published: January 2022

This study was designed to assess the knowledge, attitude, and practices of Nigerian optometrists and optometry students with regard to the COVID-19 pandemic, while also assessing its impact of their daily personal and professional routines. The Google Forms suite was used to design an online struc- tured survey/questionnaire. This was sent to Nigerian optometrists and optometry students along with a message soliciting their voluntary participation. This survey took place between 10th April and 15th May 2020. The responses received were electronically transmitted to the authors and populated via Google suite software. Descriptive statistics and inferences were then derived from these data. A total of 399 valid responses were logged during this study. Of these, 183 (45.4%) respondents were optometry students from the eight optometry education departments in Nigeria. Optometric doctors made up 216 of the respondents. 86% of optometrists reported having cases of COVID-19 in their state. No optometrists reported suffering from the COVID-19 disease while one (0.5%) student had been infected with COVID-19. Twelve percent of student respondents felt educational facilities were adequate to cater for post COVID- 19 resumption, while 21.5% of students felt that the ongoing academic session should be restarted. The COVID-19 Pandemic has impacted greatly on service delivery among Nigerian optometrists and optometry education. Educational institutions must also adjust to current realities in order to be able to provide safe and adequate training when the academic section resumes or restarts.
Variability of Indian summer monsoon: Relationship with surface air temperature anomalies over northern hemisphere
Authors: VERMA R. K. 
Published: January 2022

Thirty year (1950-79) time series of Monsoon Index (MI) is correlated with the gridded surface air temperature data over northern hemisphere land at various time lags of months (i.e., months preceding concurrent and succeeding to the monsoon season) to identify tele-connections of monsoon with the northern hemisphere surface air temperature anomalies. .

Out of three key regions identified which show statistically significant relationship of monsoon rainfall, two regions are in the higher latitudinal belt of 40oN- 70oN over North America and Eurasia which show positive correlations with temperatures during northern winter particularly during January and February. The third region is located over northwest India and adjoining Pakistan, where the maximum positive correlation is observed to occur during the pre-li1onsoon months of April and May. These relationships suggest that cooler northern hemisphere during the preceding seasons of winter/spring over certain key regions are generally associated with below normal summer monsoon rainfall over India and vice-versa which could be useful predictors for long-range forecasting of monsoon.

There are two large regions in the northern tropics, namely, Asian and African monsoons whose temperatures reveal strong negative correlations with monsoon rainfall during the seasons concurrent and subsequent to the summer monsoon season. However, persistence of this relationship for longer period of about two seasons after the monsoon, suggests the dominant influence of ENSO (El. Nino-Southern Oscillation) on tropical climate.
Observational aspects including weather radar for tropical cyclone monitoring
Authors: RAGHAVAN S. 
Published: January 2022

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In the context of the Forecast Demonstration Project (FDP) of the India Meteorological Department (IMD), a review is made of the various observational facilities and techniques which can be deployed, for the detection tracking and understanding of tropical cyclones. The real test of the efforts in terms of technology is the performance of our forecasts in an operational context. The paper discusses the steps needed in this regard.
Green Synthesis of Lactone‐Based Conjugated Polymers for n‐Type Organic Electrochemical Transistors
Authors: Wang Yazhou , Zeglio Erica , Wang Lewen , Cong Shengyu , Zhu Genming , Liao Hailiang , Duan Jiayao , Zhou Yecheng , Li Zhengke , Mawad Damia , Herland Anna , Yue Wan , McCulloch Iain 
Published: January 2022

AbstractAs new and better materials are implemented for organic electrochemical transistors (OECTs), it becomes increasingly important to adopt more economic and environmentally friendly synthesis pathways with respect to conventional transition‐metal‐catalyzed polymerizations. Herein, a series of novel n‐type donor–acceptor‐conjugated polymers based on glycolated lactone and bis‐isatin units are reported. All the polymers are synthesized via green and metal‐free aldol polymerization. The strong electron‐deficient lactone‐building blocks provide low‐lying lowest unoccupied molecular orbital (LUMO) and the rigid backbone needed for efficient electron mobility up to 0.07 cm2 V−1 s−1. Instead, polar atoms in the backbone and ethylene glycol side chains contribute to the ionic conductivity. The resulting OECTs exhibit a normalized maximum transconductance gm,norm of 0.8 S cm−1 and a μC* of 6.7 F cm−1 V−1 s−1. Data on the microstructure show that such device performance originates from a unique porous morphology together with a highly disordered amorphous microstructure, leading to efficient ion‐to‐electron coupling. Overall, the design strategy provides an inexpensive and metal‐free polymerization route for high‐performing n‐type OECTs.
Highly Polarized Light Emission of Monolayer WSe2 Coupled with Gap‐Plasmon Nanocavity
Authors: Zhu Guangpeng , Shi Xiuqi , Huang Guangyan , Liu Kaizhen , Wei Wei , Guo Qianqian , Du Wei , Wang Tao 
Published: January 2022

AbstractAs contemporary star materials, 2D monolayer semiconductors have drawn huge research interests owing to their striking electrical and optical properties, rendering them ideal candidates as building blocks for novel optoelectronic devices. Towards light emitting devices with extended functions, it is necessary to manipulate the polarization of light emission from monolayer semiconductors. However, most of these monolayer semiconductors exhibit no or very limited polarization sensitivity inherited from their structural anisotropy, making it challenging to develop highly polarized light sources. Herein, by embedding monolayer tungsten diselenide (WSe2) in a nanowire‐on‐film nanocavity, highly polarized light emission is demonstrated, featuring degree of polarization (DoP) of ≈99%. The highly anisotropic light emission originates from the near‐field coupling between the WSe2 monolayer with the polarization‐dependent gap plasmons of the nanowire‐on‐film nanocavity. Moreover, as the width of the nanowire essentially defines the gap‐plasmon resonance of the nanowire‐on‐film nanocavity, the anisotropy of the highly polarized light emission is systematically tuned by changing the nanowire width. The findings pave the way for engineering anisotropic optical properties of monolayer semiconductors and will boost the development of functional polarization‐sensitive 2D optoelectronic devices.
Self‐Driving Perovskite Dember Photodetectors
Authors: Cao Guoyang , Zhang Haoyu , Wang Changlei , Li Xiaofeng 
Published: January 2022

AbstractDember effect is a potential mechanism for realizing self‐driving photodetection. Unfortunately, both the optoelectronic prediction and the experimental realization of the Dember photodetectors (DPDs) are challenging. Based on perovskite material, the theoretical prediction, numerical simulation, and experimental fabrication of the self‐driving DPDs are performed. The theoretical prediction presents a complete expression of the Dember‐voltage for the detailed physical explanation and manipulation of the Dember effect. The device‐level optoelectronic simulation is further realized to show a good agreement with the theoretical prediction, allowing to detailedly explore the excitation conditions of the Dember mechanism and obtain the optoelectronic responses of the device. The device simulation shows that the proposed DPD is sensitive to a broadband spectrum (300–750 nm), with a photo‐responsivity of 3.8 A W–1, specific detectivity of 3.5 × 109 Jones, and response time of 0.13 µs at 500 nm wavelength and zero‐bias. Moreover, the photodetector is successfully fabricated and the Dember‐driving photocurrent and photoelectric response are observed, with the realized photo‐responsivity, specific detectivity, and rise (decay) time up to 0.11 A W–1, 1.3 × 109 Jones, and 2.6 (3.5) µs, respectively. The study provides a promising option for the realization of high‐performance self‐driving photodetectors via Dember‐effect.
Regulatory Variant rs2535629 in ITIH3 Intron Confers Schizophrenia Risk By Regulating CTCF Binding and SFMBT1 Expression
Authors: Li Yifan , Ma Changguo , Li Shiwu , Wang Junyang , Li Wenqiang , Yang Yongfeng , Li Xiaoyan , Liu Jiewei , Yang Jinfeng , Liu Yixing , Li Kaiqin , Li Jiao , Huang Di , Chen Rui , Lv Luxian , Xiao Xiao , Li Ming , Luo Xiong‐Jian 
Published: January 2022

AbstractGenome‐wide association studies have identified 3p21.1 as a robust risk locus for schizophrenia. However, the underlying molecular mechanisms remain elusive. Here a functional regulatory variant (rs2535629) is identified that disrupts CTCF binding at 3p21.1. It is confirmed that rs2535629 is also significantly associated with schizophrenia in Chinese population and the regulatory effect of rs2535629 is validated. Expression quantitative trait loci analysis indicates that rs2535629 is associated with the expression of three distal genes (GLT8D1, SFMBT1, and NEK4) in the human brain, and CRISPR‐Cas9‐mediated genome editing confirmed the regulatory effect of rs2535629 on GLT8D1, SFMBT1, and NEK4. Interestingly, differential expression analysis of GLT8D1, SFMBT1, and NEK4 suggested that rs2535629 may confer schizophrenia risk by regulating SFMBT1 expression. It is further demonstrated that Sfmbt1 regulates neurodevelopment and dendritic spine density, two key pathological characteristics of schizophrenia. Transcriptome analysis also support the potential role of Sfmbt1 in schizophrenia pathogenesis. The study identifies rs2535629 as a plausibly causal regulatory variant at the 3p21.1 risk locus and demonstrates the regulatory mechanism and biological effect of this functional variant, indicating that this functional variant confers schizophrenia risk by altering CTCF binding and regulating expression of SFMBT1, a distal gene which plays important roles in neurodevelopment and synaptic morphogenesis.
Modeling of gas–liquid flow in a rotating packed bed using an Eulerian multi‐fluid approach
Authors: Zhang Wei , Xie Peng , Li Yuxing , Zhu Jianlu 
Published: January 2022

AbstractRotating packed beds (RPBs) are ideal candidates for CO2 removal from offshore natural gas due to their good mass transfer performance and significant volume savings. This article proposes an Eulerian multi‐fluid approach to simulate the gas–liquid flow in RPBs. Three new multiphase drag force models are constructed based on single‐phase drag force models for wire mesh packings. Based on the Eulerian multi‐fluid approach, a new RPB simulation framework is developed. The predicted results using the new simulation framework with the new drag force models are compared with the experimental data. When using the Kołodziej model and the modified Kołodziej model, the predicted overall liquid holdup shows good agreement with the experimental data with errors less than 20%. In addition, the pressure drop predicted by these three models are reasonable compared with the experimental data. This work lays a foundation for RPB simulation of gas–liquid flow using Eulerian multi‐fluid approach.