bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the short-term results of transcutaneous tibial nerve stimulation in male patients with overactive bladder
Authors: Donmez Ulku , Turan Turgay , Suluova Ali 
Published: February 2025

Abstract

Background The aim of this study is to evaluate the short-term results of consecutive transcutaneous posterior tibial nerve stimulation on quality of life and symptoms in the treatment of male patients with overactive bladder symptoms.Materials and methods Patients who came to the urology outpatient clinic with frequent urination, urgency, nocturia and/or urinary incontinence and who were diagnosed with overactive bladder were included in the study. 62 male patient were divided into 2 groups. The first group was treated with only standard medical therapy (anticholinergic) and second group was treated transcutaneous posterior tibial nerve stimulation in addition to them. Transcutaneous posterior tibial nerve stimulation treatment was adjusted to be 3 sessions per week for 6 weeks. All patients were evaluated at 0., 2. and 4 months. Overactive bladder score, quality of life form (SF-12), number of urinary episodes, and incontinence were recorded.Results In both groups, there was a decrease in all clinical symptoms of overactive bladder and an improved quality of life scores at the end of treatment, with statistical significance (p < 0.05). In the intergroup comparison, the improvement of all parameters in the transcutaneous posterior tibial nerve stimulation group was found to be more significant than the medical group at the end of the 4th month.Conclusion Transcutaneous posterior tibial nerve stimulation administered addition to standard medical treatment is effective on symptoms and quality of life in the treatment of male patients with overactive bladder.Clinical Trial Number: Not applicable.
Caveolae-Mediated Sensing of Nanoporous Cues in Fibroblasts Reprogramming During Wound Healing
Authors: Shi Keqing , Guo Feixia , Xie Wei , Lin Wante , Yi Meilin , Li Haobing , Niu Xiaoying , Abdo Ebrahim , Wang Hongwei , Wang Shunfu , Wang Jian , Xiao Jian , Chen Zimiao 
Published: February 2025

Abstract

Scaffolds with pores can influence cellular fate and tissue microenvironments by altering intracellular and intercellular signaling pathways, which are crucial for guiding tissue regeneration. Despite their significance, the cellular mechanisms behind the response to pores, especially at the nanoscale, are not well understood. Our study shows that scaffolds with different nanopore characteristics can enhance skin regeneration in various ways, with fibroblasts being the primary cellular responders. We have demonstrated that caveolae formation is a critical mechanism by which fibroblasts interact with nanopores. The phosphorylation of caveolin-1 (Cav1) is a key event in this process, enabling caveolae-mediated endocytosis and the subsequent internalization of cellular substances. This initiates a cascade of events involving the internalization of cell surface receptors such as PDGFRβ, activation of tyrosine kinase pathways including PI3K, AKT, and ERK1/2, and the phosphorylation of the transcription factor RUNX1. The nuclear translocation of RUNX1 upregulates the expression of fibroblast growth factor binding protein 3 (FGFBP3), which is a key factor in tissue repair. Additionally, cytoplasmic Cav1 can competitively bind to Filamin-A, releasing CBFβ, which then translocates to the nucleus and enhances RUNX1's DNA-binding affinity, synergistically activating FGFBP3 transcription and promoting tissue healing. Collectively, our findings underscore the importance of considering nanopore characteristics in scaffold design for tissue regeneration and highlight caveolae formation as a central mediator of cellular responses to nanoporous environments, initiating a multitude of biological processes essential for tissue repair and regeneration.
An Ultra-Long-Acting Dimeric Bictegravir Prodrug Defined by a Short Pharmacokinetic Tail
Authors: Edagwa Benson , Nayan Mohammad Ullah , Sillman Brady , Das Srijanee , Hanson Brandon , Sultana Ashrafi , Le Nam Thai Hoang , Deodhar Suyash , Dash Alekha , Cohen Samuel , Gendelman Howard 
Published: February 2025

Abstract

Ultra-long-acting (ULA) antiretroviral parenteral formulations, with low injection volumes, high resistance barriers, and short pharmacokinetic (PK) tails, can transform HIV-1 therapeutics. Here, we converted bictegravir (BIC), a potent daily oral antiretroviral drug, into monomeric and homodimeric ester prodrugs. The homodimeric prodrug nanosuspension, NMXBIC, shows sustained plasma BIC levels > 16 times the protein-adjusted 95% inhibitory concentration (PA-IC95) for six months after a single injection in Sprague Dawley rats. The results paralleled a short PK tail with the potential for late dose forgiveness. The monomeric prodrug nanosuspension, NM2BIC, shows lower year-long plasma BIC concentrations above PA-IC95 after a single injection in Sprague Dawley rats. After repeated injections, NMXBIC and NM2BIC are well tolerated in New Zealand White rabbits. NMXBIC’s physicochemical properties and high BIC loading/unit mass of the prodrug contribute to its unique ULA PK profile. These results support its development as a ULA formulation for HIV-1 treatment and prevention.
In silico approach for the prospecting of molecules from Cereus jamacaru (Cereeae) in the treatment of obesity and cardiovascular diseases
Authors: Cardoso Maria Izadora Oliveira , Oliveira Júlia , Bassaneze V. , Amaral D. T. 
Published: February 2025

Abstract

The Caatinga biome in Brazil is home to unique plant species with significant bioactive potential, such as Cereus jamacaru (Mandacaru). Historically used in traditional medicine for treating kidney issues, diabetes, and cardiovascular conditions, this plant contains macromolecules, which may play a role in therapeutic applications. Here, we integrate transcriptomics, molecular docking, and molecular dynamics approaches to explore the potential of C. jamacaru proteomics to binding to triacylglycerol molecules, particularly targeting triacylglycerol formed by lauric, myristic, and palmitic acids. Transcriptome analysis identified 128,942 transcripts, with 14,739 homologous proteins screened for binding affinities. Molecular docking highlighted an isoform of Banyan Peroxidase as a versatile candidate, exhibiting strong binding energies across all triacylglycerols, particularly palmitic acid (-7.632 kcal/mol). Xyloglucan Endotransglycosylase demonstrated specificity for myristic acid (-7.752 kcal/mol), while Non-specific Lipid-Transfer Protein showed exceptional structural stability in dynamic simulations. The molecular dynamics simulations, performed over 100 ns, revealed key insights into protein stability and ligand interactions. Banyan Peroxidase displayed moderate flexibility, enhancing its adaptability to diverse triacylglycerol substrates. Conversely, Xyloglucan Endotransglycosylase exhibited compact stability, making it a strong candidate for targeted new applications. These findings highlight the untapped potential of C. jamacaru as a source of bioactive proteins, bridging traditional knowledge with advanced computational methodologies.
Sexual identity inequalities in the co-occurrence between poor mental health and health risk behaviours – A national cohort study
Authors: Khanolkar Amal R. , Karamanos Alexis , Becares Laia 
Published: February 2025

Abstract

Background
Mental health challenges (MHC) like depression and anxiety, and health and risk behaviours (HRBs) are more common among sexual minority adolescents (SMA) than in heterosexual peers. Limited studies have examined the co-occurrence between poor mental health and HRBs, whether risk for co-occurrence differs by sexual identity, and associated risks for self-harm and attempted suicide in adolescents in the UK.
Methods
This study included 10,233 adolescents aged 17 (51% female and 11% sexual minority) from the UK-wide Millennium Cohort Study. Sexual identity, MHC, HRBs, self-harm and attempted suicide were self-reported by adolescents. MHC were assessed using the strengths and difficulties questionnaire [SDQ] emotional symptoms subscale for depression/anxiety. Seven common HRBs (like regular smoking, drug use and risky sexual behaviour) were assessed. Associations between sexual identity and risk for co-occurrence between MHC and HRBs were assessed using multinomial logistic regression. Predicted probabilities for self-harm or attempted suicide based on sexual identity and MH-HRB co-occurrence status were estimated using logistic regression models with appropriate interactions terms (between sexual identity and MH-HRB co-occurrence status variables).
Results
MHC prevalence was higher in gay/lesbian (48%) and bisexual (49%) adolescents compared to heterosexual peers (19%). Prevalence of self-harm (bisexual: 64%, gay/lesbian:53%, heterosexual:19%) and attempted suicide (bisexual: 24%, gay/lesbian:17%, heterosexual:6%) were higher in sexual minority adolescents compared to heterosexual peers. Gay/lesbian and bisexual adolescents consistently reported higher risk for MH-HRB co-occurrence compared to heterosexual peers (for example, for gay/lesbian individuals: RRR3.16 [95% CI 2.14–4.68] for MH-1HRB, RRR3.54[95% CI 2.06–6.08] for MH-≥3HRB, for bisexual adolescents, RRR2.44 [95% CI 1.85–3.20] for MH-1HRB, RRR4.11[95% CI 2.99–5.66] for MH-≥3HRB). MH-HRB co-occurrence and sexual minority identity were independently associated with risk for self-harm or attempted suicide. Gay/lesbian and bisexual adolescents experienced higher probabilities of reporting self-harm than heterosexual peers with the same level of MH-HRB co-occurrence. For example, 37.2% of heterosexual adolescents with MH-1HRB reported self-harm. Corresponding numbers were more than twice as high in bisexual (75.7%) and gay/lesbian (77.9%) individuals. Similarly, 58.3% of heterosexual adolescents with MH-≥3HRBs reported self-harm, which increased to 84.6% in bisexual and 83.8% in gay/lesbian peers.
Conclusions
SMA are more likely to experience MH-HRB co-occurrence, which is also associated with substantially higher risks for self-harm and attempted compared to heterosexual peers. Our findings highlight the need for better public health policies to address poor mental health and associated comorbidities to reduce inequalities in adolescence.
A circular economy approach for the global lithium-ion battery supply chain
Authors: Wu Yufeng , Zhai Mengyu , Tian Shaonan , Yuan Haoran , Luo Xubiao , Huang Guohe , Fu Yupeng , Zhu Mengye , Gu Yifan , Huan Wei , Dai Yu , Wang Huaidong , Yang Liming , Li Bin , Yin Xiaofei , Liu Gongqi , gu jing , Wang Yazhuo , Chen Yong , Zuo Tieyong 
Published: February 2025

Abstract

The lithium-ion battery supply chain is critical for global decarbonization, yet its geographically dispersed production stages pose significant challenges for carbon emission management. Here, we develop a lithium cycle computable general equilibrium model (LCCGE) that integrates a lifecycle assessment with regional economic dynamics to systematically evaluate carbon emissions and circular economy strategies across the global supply chain. Our analysis reveals that while downstream cathode production generates 42.1% of the economic value with only 34.8% of the emissions, upstream mining contributes merely 18.5% of the value but accounts for 38.6% of the total emissions (217.08 Mt CO₂-eq). Through a comprehensive scenario analysis of circular economy pathways, we demonstrate that consumer-oriented recycling strategies achieve optimal emission intensity reduction (16.30% by 2060), which is particularly effective in East Asian economies. Our proposed technology-oriented cross-regional circular economy framework (J020-R222) yields the highest emission reduction potential (32.98% globally), with manufacturing powerhouses demonstrating exceptional capabilities (U.S. 39.53%, EU 37.10%, China 34.46%). By integrating environmental, technological, and trade strategies in a circular economy context, these findings provide critical insights for developing regionally tailored yet globally coordinated decarbonization pathways while establishing a novel methodological framework for analysing complex supply chain sustainability through circular economy approaches.
Association between serum creatine kinase levels and the risk of all-cause mortality among centenarians: A prospective cohort study in China
Authors: Gong Xinyan , Zhang Qingtao , Niu Yue , Yu Xiang , Ji Yuwei , Wang Baolong , Hu Hongyan , Zhu Qiao , Chen Yujian , Ning Chaoxue , Fu Shihui , Yang Shanshan , Wang Shengshu , Liu Miao , Zhao Yali , He Yao , Jin Xinye , Zhang Jie , Luo Qing , Sun Ding , Li Hao , Zhang Zehao , Qu Zeyu , Chen Xiangmei , Chen Yizhi , Feng Zhe 
Published: February 2025

Abstract

Background
Muscle mass (MM) was important because of its strong correlation with all-cause mortality. However, its assessment was complex, nonportable and expensive. Serum creatine kinase (CK) was proposed to counteract this problem. However, its correlation with all-cause mortality was unknown.
Objectives
The aim of this study was to investigate the associations between serum CK levels and all-cause mortality risk in Chinese centenarians.
Methods
A prospective cohort study of centenarians was conducted to classify serum CK levels according to all-cause mortality via restricted cubic spline (RCS) analysis, Cox regression analysis and Kaplan‒Meier analysis.
Results
We included 949 participants with a median follow-up of 29.4 months (interquartile range (IQR) 14.5, 51.7). A total of 92.9% of the subjects died. The RCS analysis revealed an inverse J-shaped relationship between the serum CK level and the risk of death. The mortality rate of centenarians with serum CK levels ranging from 8–66 U/L (Q1–Q2) was 34.3% higher than that of those with serum CK levels ranging from 66–192 U/L (Q3–Q4) (multivariable analysis hazard ratio (HR), 1.343; 95% confidence interval (CI), 1.173–1.538; P < 0.001). Kaplan–Meier analyses revealed that centenarians with lower serum CK levels had significantly shorter median survival time (Q1‒Q2 versus Q3‒Q4: 26 months versus 36 months, log-rank P < 0.001).
Conclusions
Serum CK levels were negatively associated with centenarian mortality, indicating that they may predict mortality risk in centenarians. CK could be utilized as an independent predictor of mortality in centenarians.
Clinical Trial Registry number and website where it was obtained.
Not applicable.
Registry and registry number for systematic reviews or meta-analyses.
Not applicable.
Self-Efficacy is Associated with Health Behaviors Related to Obesity and Cardiovascular Risk among Hispanic/Latinx and Somali Immigrants to the United States
Authors: Tranby Brianna , Sia Irene , Clark Matthew , Novotny Paul , Lohr Abby , Pardo Laura Suarez , Patten Christi , Iteghete Sheila , Zeratsky Katherine , Rieck Thomas , Molina Luz , Capetillo Graciela Porraz , Ahmed Yahye , Dirie Hana , Wieland Mark 
Published: February 2025

Abstract

Background:
Self-efficacy theory proposes that confidence to engage in a health behavior is associated with engaging in that specific behavior. Most research examining self-efficacy has been conducted with white young adult populations. This secondary analysis examined the association of self-efficacy (i.e., confidence) for healthy eating and physical activity in two immigrant communities.
Methods:
At enrollment into the Healthy Immigrant Community study, a clinical weight management and cardiovascular risk reduction intervention set in southeastern [state], 475 participants completed assessments about their confidence for healthy eating and physical activity. Measurements also included self-reports of dietary quality and intake, physical activity, quality of life, and biometric assessments. Study materials were available in English, Spanish, and Somali.
Results
In total, 450 adults (Hispanic/Latinx = 267; Somali = 183) completed measures at baseline and were included for analysis. Their average age was 45 years (range 18–87) and 59% were female. Confidence for healthy eating was significantly associated with self-report of eating healthy snacks (p = < 0.0001) and less consumption of high-calorie drinks (p = 0.02) and regular soda (p = < 0.0001). Confidence to be physically active was significantly associated with more self-reported physical activity (p = < 0.01).
Conclusions
Confidence to eat healthy and be physically active appears to be associated with having a healthier diet and higher levels of physical activity. Given the large sample size and strength of the associations, it also appears that the theoretical model of self-efficacy can be effectively measured and applied within these immigrant populations. Self-efficacy theory may be useful in understanding potential mediating mechanisms when designing future interventions with immigrant communities.
ClinicalTrials.gov registration:
NCT05136339; April 23, 2022
Analyzing Sentiments towards Performance of New Academic Programs in A Ghanaian University: A Case of Ghana Communication Technology University
Authors: Susuassey Wonder Kwaku , Adjei Daniel , Agbeli Deborah Esenam , Asante Emmanuel Frimpong , Mensah Dorinda Nyarko 
Published: February 2025

Abstract

Introduction of new programs in educational institutions in Ghana requires the introduction of a new curriculum. However, the performance of the new programs after the admission of students into the programs becomes questionable as the least performance is achieved. As Ghanaian univer- sities continue to expand their curriculum to meet the evolving demands of the digital economy, understanding the perceptions and experiences of the academic community becomes essential for gauging the success and potential areas for improvement of these programs. The study performs a supervised sentiment analysis on reviews gathered from students enrolled in new academic pro- grams towards the recommendation of the programs to people. The primary data for this study were drawn from a sample of 226 students, using both open-ended and closed-ended structured questionnaires. In the study, four machine learning methods, including Multinomial Naı̈ve Bayes, Support Vector Machine, Logistic Regression, and Random Forest were applied. The methods are compared, and the empirical findings reveal that the Support Vector Machine and Random For- est approaches outperformed the Multinomial Naı̈ve Bayes and Logistic Regression approaches, resulting in generally positive sentiment towards the performance of the new academic programs. By analyzing the sentiments of students, the study recommends actionable insights that can guide the university in enhancing its academic offerings and aligning them with the expectations of its community.
«Пиренейский мир»: Испания и Португалияв системе внешнеполитических приоритетовАнглии в 1640–1688 годах.
Authors: Гордиенко Д.О. 
Published: February 2025

Статья посвящена проблемам англо-пиренейских отношений в 1640–1668 гг. В ней показано важное значение полуострова для Англии в XVI веке. В деталях прослеживается роль англо-испанских и англо-португальских отношений в середине XVII века. Раскрыто место королевского двора в англо-испанских отношениях во время войны 1654–1660 гг. и показана роль англо-португальского брачного союза 1661 г. в контексте формирования Британской колониальной империи. Дается анализ действиям английской бригады в португальской войне за независимость 1660 года.
The article is devoted to the problems of Anglo-Pyrenean relations in 1640–1668. The important place of the Peninsula for England in the XVI century is shown. The role of Anglo-Spanish and Anglo-Portuguese relations in the middle of the XVII century is traced in detail. The place of the royalist court in the Anglo-Spanish relations during the war of 1654–1660 is revealed. The place of the Anglo-Portuguese marriage alliance of 1661 in the aspects of the British colonial Empire formation is shown. The actions of the English brigade in the Portuguese war of independence in 1660 are analyzed.
Место и роль католических джентрив ирландском обществе XVIII века
Authors: Лагошина Н.А. 
Published: February 2025

Укрепление позиций Британской империи XVIII в. привело к необходимости установления контроля над соседней Ирландией, имеющей тесные торгово-экономические связи с католической Европой. Несмотря на ограничительный характер, последствия уголовных законов, предназначенных для поддержания протестантской власти в стране, благотворно отразились на положении большинства католиков, являющихся посредниками в аренде недвижимости и главными арендаторами крупных поместий. Источники показывают, что социальный статус и общественное влияние католических посредников, обеспечивающих взаимодействие землевладельцев с конечными арендаторами, были значительно выше, чем предполагалось ранее в зарубежной историографии. Интерес потомков гэльской знати к народной культуре, исполнение основных административно-политических функций в графствах способствовали развитию стратегии адаптации к новым общественно-политическим реалиям. В статье изучаются место и роль католических посредников в ирландском обществе, их традиционные практики взаимодействия, обеспечившие выживание ирландских католиков в XVIII в.
The strengthening of the position of the British Empire in the XVIIIth century led to the need to establish control over neighboring Ireland, which has close trade and economic ties with Catholic Europe. Despite its restrictive character, the economic consequences of Penal laws designed to maintain Protestant power in the country have had a beneficial effect for the most part Catholics who are intermediaries and tenants of large estates. Historical sources demonstrate that the social status and social influence of Catholic middleman that ensure interaction between landlords and final tenants were significantly higher than it previously assumed in foreign historiography. The involvement of the descendants of the Gaelic nobility in popular culture and the performance of the main administrative and political functions in the counties contributed to the development of a strategy of adaptation new socio-political realities. The article examines the position and role of Catholic gentry in the Irish society, their traditional cultural characteristics and interaction practices that ensured the survival of the Irish Catholics in the State.
В постижении «мира, утраченного нами»:дискуссия об этногенезе пиктов и скоттовв британской историографии
Authors: Ласкова Н.В. 
Published: February 2025

Статья посвящена проблеме этногенеза шотландцев. Рассматриваются концепции о происхождении пиктов и скоттов в британской историографии. Показаны основные представления и спорные моменты по вопросу о формировании шотландской этнической общности. Подчеркивается актуальность этой проблемы посредством связи рассматриваемых этнокомпонентов с возникновением шотландского государства и становления шотландской монархии. Отмечена связь теорий об этногенезе шотландского народа с политическими аспектами британской истории.
The article is devoted to the problem of ethnogenesis of Scots. Concepts about the origin of Picts and Scots in British historiography are considered. The main ideas and controversial points on the formation of the Scottish ethnic community are shown. The relevance of this problem is emphasized through the connection of the considered ethnocomponents with the emergence of the Scottish state and the formation of the Scottish monarchy. The connection of theories about the ethnogenesis of the Scottish people with political aspects of British history is noted.