bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid pressureless sintering of barium titanate–based piezoceramics and their electromechanical harvesting performance
Authors: Bijalwan Vijay , Prajzler Vladimír , Erhart Jiří , Velazquez Jose J. , Galusek Dušan , Maca Karel 
Published: June 2022

AbstractThe innovative method of processing of Ba0.85Ca0.15Zr0.1Ti0.9O3 (BCZT), Ba0.95Ca0.05Ti0.91Sn0.09O3 (BCST), and BCZT doped with 0.07‐wt.% CeO2 (Ce‐BCZT) lead‐free piezoceramics is presented. The rapid pressureless sintering (RPLS) technique can reduce high‐temperature processing time more than eight times compared to the conventional sintering. RPLS was performed at a heating and cooling rate of 100°C/min up to 1550°C with 15‐, 30‐, 45‐, and 60‐min dwell times, producing defect and crack‐free nearly dense ceramics. The optimal microstructure exhibiting the highest piezoelectric constant was reached after 30 min in BCZT (grain size 25–30 μm, d33 = 428 pC/N), 45 min in Ce‐BCZT (grain size 30–35 μm, d33 = 515 pC/N), and 45 min of dwell time in BCST (grain size 58–68 μm, d33 = 443 pC/N). The highly competitive energy‐harvesting properties were discovered for BCZT, resp. Ce‐BCZT (ƞ = 94.5, resp. 93.4%, FOMoff = 6.1, resp. 7.8 × 10−10 m2/N) ceramics.
P‐doped MoS2/Ni2P/Ti3C2Tx heterostructures for efficient hydrogen evolution reaction in alkaline media
Authors: Ma Wansen , Liu Dong , Gao Feiyu , Lv Zepeng , Lv Xuewei , Li Yong , You Yang , Dang Jie 
Published: June 2022

AbstractBy combining the advantages of doping to change the electronic structure of molybdenum disulfide (MoS2), transition metal phosphides, and MXene, we proposed the idea of designing and preparing a new type of composite material, P‐doped MoS2/Ni2P/Ti3C2Tx heterostructures (denoted as P@MNTC), to serve as the hydrogen evolution reaction (HER) catalyst of electrochemical water splitting. The as‐prepared P@MNTC heterostructures show a significant HER activity with an overpotential of 120 mV at 10 mA cm–2 in alkaline electrolyte, with decreasing 105 and 125 mV compared with those of MoS2 and MXene, respectively. The density functional theory indicates that the P doping and synergy effect of Ti3C2Tx can enhance the activation of MoS2 and thus promote dissociation and absorption of H2O during HER process. This strategy provides a promising way to develop high‐efficiency MoS2‐ and Ti3C2Tx‐based composite catalysts for alkaline HER.
From Janusz Korczak’s Democratic Pedagogy to Sharon Lockhart’s Artistic Project: Pedagogical Inspiration in Contemporary Art
Authors: Kwiatkowska‐Tybulewicz Barbara 
Published: June 2022

AbstractThe aim of this article is to present pedagogical inspirations in contemporary art. In pedagogical research and analyses, we more frequently pose questions about the artistic inspirations for educational theory and practice. In the face of the educational turn in contemporary art and culture, it is worth considering inspiration in the opposite direction. The article discusses the project Little Review by the American artist Sharon Lockhart, which was shown during the 57th Venice Biennale of Art (2017). This artistic project was inspired by the democratic and alternative pedagogy of a Polish pedagogue of Jewish origin, Janusz Korczak, who was active before World War II. The characteristic element of such projects, which sit on the border of art and education, is their reference to radical pedagogy and alternative teaching and learning. Today, artists using educational methods look not to official conventional education for inspiration but to non‐formal and alternative models. The Little Review is a good example of this type of inspiration in artistic activity. The article briefly presents the democratic pedagogy of Korczak and indicates its influence on the artistic project realised by Sharon Lockhart. It demonstrates the significant opportunities offered by this type of artistic and educational interweaving for both art and education.
Effect of thermotherapy, Leifsonia xyli subsp. xyli titres, sugarcane genotype and diagnostic techniques on ratoon stunt control in Brazil
Authors: Andreato Caroline , Gazaffi Rodrigo , Oliveira Maysa Mariano Aguiar , Camargo Luis Eduardo Aranha , Urashima Alfredo Seiiti 
Published: June 2022

Abstract

Aims
To examine the interaction of diagnostic techniques, initial titres of Leifsonia xyli subsp. xyli (Lxx), sugarcane genotype and thermotherapy on ratoon stunt (RSD) control.

Methods and Results
Single buds of RB867515, RB92579 and RB966928 were submitted to 50°C/2 h or 52°C/30 min under factorial block design and five replications; results were checked 9 months later by serological (DBI) and molecular (PCR) techniques. A 10,000 bootstrapping simulations were performed to infer the best plot size based on the experimental coefficient of variation. Analysis of variance showed significance only on initial Lxx titres and RSD control. Despite the absence of significance in the overall analysis, minor differences in control success with different methods and cultivars are predicted to have a major epidemiological impact on RSD, considering successive harvests and vegetative increase. According to an epidemiological interpretation, the 50°C/2 h treatment was more effective, cultivar RB966928 was the most susceptible and the PCR-based method was the most sensitive for pathogen detection. The minimum required plants per plot was 15, indicating high precision of our experiment

Conclusions
Data interpretation considered both the statistical analysis and the epidemiology aspect of RSD in order to improve RSD management. The Brazilian sugarcane industry will benefit from this approach since it is not using it.

Significance and Impact of the Study
This is the first study that examined multiple factors that affect RSD control. Our work pinpointed the importance of the thermotherapy, its best combination as well as the diagnostic test. Also, the effect of the cultivar to respond to management strategies. Because the epidemiological aspect of RSD was taken into consideration, results of our work can have an impact on RSD control in the field.
Role of plasma phosphorylated neurofilament heavy chain (pNfH) in amyotrophic lateral sclerosis
Authors: Zecca Chiara , Dell’Abate Maria Teresa , Pasculli Giuseppe , Capozzo Rosa , Barone Roberta , Arima Serena , Pollice Alessio , Brescia Vincenzo , Tortelli Rosanna , Logroscino Giancarlo 
Published: June 2022

AbstractThe phosphorylated neurofilament heavy chain (pNfH) is a promising biomarker in amyotrophic lateral sclerosis (ALS). We examined plasma pNfH concentrations in order to corroborate its role as a diagnostic and prognostic biomarker in ALS. Incident ALS cases enrolled in a population‐based registry were retrospectively selected and matched by sex and age with a cohort of healthy volunteers. Plasma pNfH levels were measured by an ELISA kit and correlated with clinical parameters. Discrimination ability of pNfH was tested using receiving operating characteristic (ROC) curves. Kaplan–Meier (KM) analysis and Cox proportional hazard models were used for survival analysis. Plasma pNfH was significantly higher in patients compared to controls. An optimal cut‐off of 39.74 pg/ml discriminated cases from controls with an elevated sensitivity and specificity. Bulbar‐onset cases had higher plasma pNfH compared to spinal onset (p = 0.0033). Furthermore, plasma pNfH positively correlated with disease progression rate (r = 0.19, p = 0.031). Baseline plasma pNfH did not influence survival in our cohort. Our findings confirmed the potential utility of plasma pNfH as a diagnostic biomarker in ALS. However, further studies with longitudinal data are needed to corroborate its prognostic value.
Expert consensus on personalized initiation of glucose‐lowering therapy in adults with newly diagnosed type 2 diabetes without clinical cardiovascular disease or chronic kidney disease
Authors: Zhang Fang , Ji Linong , Hong Tianpei , Guo Lixin , Li Yan , Zhu Zhiming , Liu Xingbin , Liu Fang , Tang Lizhi , Zhang Yuwei , Li Juan , Lü Qingguo , Tong Nanwei 
Published: June 2022

AbstractSince it is difficult for clinicians to make a decision among the various types of antidiabetic medications due to their great discrepancy in mechanisms, pharmacological properties, and cardiovascular/renal protection, a relatively “precision” or personalized hypoglycemic treatment suggestion is practical for type 2 diabetes (T2D) management in adults. This expert consensus makes some recommendations based on the characteristics of adult T2D patients without clinical cardiovascular disease (CVD) or chronic kidney disease (CKD) by evidence from large‐scale clinical trials. The main consideration for initiating antidiabetic medications is the safety and benefits for prevention of target organ damage, such as CVD and CKD. The choice of personalized glucose‐lowering therapy regarding target organ protection is based on the various effects of antidiabetic medications, patients’ clinical characteristics and their key risks, as well as the sociological factors. According to the effects on glucose reduction, cardiovascular protection, renal benefit, body weight change, hypoglycemic risk, and liver function impact, the antidiabetic medications are recategorized in this consensus. Combined with the glucose control target and the different effects of hypoglycemic agents, a significant body of recommendations have been developed for optimal T2D management according to the risk factors for atherosclerotic CVD, heart failure, CKD, primary fatty liver, and hypoglycemia. This consensus gives detailed guidance on personalized antidiabetic therapy initiation in newly diagnosed T2D adults, which attaches great importance to both glucose control and target organ protection.
Amoxicillin‐vonoprazan dual therapy forHelicobacter pylorieradication: A systematic review and meta‐analysis
Authors: Ouyang Yaobin , Wang Minghui , Xu Yu‐Ling , Zhu Yin , Lu Nong‐Hua , Hu Yi 
Published: June 2022

AbstractBackground and AimThe efficacy and safety of amoxicillin‐vonoprazan (VA) dual therapy remained unclear.MethodsThis systematic review was conducted in accordance with the PRISMA 2009 guidelines. A systematic search of the Pubmed, Embase, and Cochrane database was conducted using the combination of “Helicobacter pyloriorH. pyloriorHp,” “amoxicillin or penicillin,” and “Vonoprazan or TAK‐438 or Takecab or (potassium AND competitive) or potassium‐competitive.” The initial and secondary outcome of this meta‐analysis was to evaluate the efficacy and safety of VA dual therapy.ResultsThree studies and 668H. pyloriinfected patients were included in this meta‐analysis. The crude eradication rate of VA dual therapy was 87.5% and 89.6% by ITT and PP analysis, respectively. No significant differences were observed regarding the VA dual therapy and vonoprazan‐amoxicillin‐clarithromycin (VAC) triple therapy according to ITT (RR = 0.99, 95% CI, 0.93–1.05,P = 0.65) and PP (RR = 0.99, 95% CI, 0.94–1.05,P = 0.82) analysis. The side effect of VA dual therapy was 19.1% (95% CI, 5.9–32.4), which was lower than that of VAC triple therapy but there was no statistical significance (RR = 0.75, 95% CI, 0.59–1.06,P = 0.12).ConclusionVA dual therapy shows acceptable efficacy, good safety and avoid unnecessary antibiotic use in the first‐line treatment forH. pyloriinfection. However, its application in other regions need to be further explored.
Tailoring prehabilitation to address the multifactorial nature of functional capacity for surgery
Authors: Gillis Chelsia , Coca‐Martinez Miquel , Santa Mina Daniel 
Published: June 2022

AbstractMounting evidence suggests that recovery begins before the surgical incision. The presurgery phase of recovery, namely the preparation for optimal surgical recovery, can be reinforced with prehabilitation. Prehabilitation is the approach of enhancing the functional capacity of the individual to enable them to withstand a stressful event. With this narrative review, we apply the Wilson and Cleary conceptual model of patient outcomes to specify the complex and integrative relationship of health factors that limit functional capacity before surgery. To have the greatest impact on patient outcomes, prehabilitation programs require individualised and coordinated care from medical, nutritional, psychosocial and exercise services.
Japanese clinical practice guidelines for aspiration and pharyngeal residual assessment during eating and swallowing for nursing care
Authors: Sugama Junko , Ishibasi Miyuki , Ota Erika , Kamakura Yayoi , Saitoh Eiichi , Sanada Hiromi , Nakayama Takeo , Nomura Takeshi , Yamada Masako , Nakagami Gojiro , Sato Naoko , Shibata Seiko , Hase Takashi , Fukada Junko , Miki Tatsuto , Arita Mikiko , Urai Tamae , Okawa Yohei , Kitamura Aya , Dai Misako , Takahashi Toshiaki , Tamai Nao , Tobita Itoko , Noguchi Hiroshi , Matsumoto Masaru , Miura Yuka , Mukai Kanae , Mugita Yuko , Yoshida Mikako , Kurachi Masako , Shirasaka Takako , Yamane Yukiko 
Published: June 2022

AbstractAimThis clinical practice guideline aims to provide and recommend methods of assessing aspiration and pharyngeal residue during eating and swallowing and methods of selecting and implementing nursing care for adults to prevent the development of aspiration pneumonia through early and appropriate management of oropharyngeal dysphagia.MethodsIn April 2018, the Japan Academy of Nursing Science established the Supervisory Committee in Nursing Care Development/Standardization Committee to develop clinical practice guidelines for aspiration and pharyngeal residual assessment during eating and swallowing for nursing care. This clinical practice guideline was developed according to the Minds Manual for Guideline Development 2017, with the aim of providing a specific pathway for nurses to determine the policy for selecting management for oropharyngeal dysphagia based on research evidence and multifaceted factors including the balance of benefits and harms and patients' values.ResultsBased on the 10 clinical questions related to assessment by physical assessment, the Repetitive Saliva Swallowing Test, Modified Water Swallowing Test, Food Test, cervical auscultation, observation using an ultrasound diagnostic device, and an endoscope, 10 recommendations have been developed. Eight recommendations have been evaluated as the Grading of Recommendations Assessment, Development and Evaluation (GRADE) 2C, and the other two have been evaluated as no GRADE.ConclusionThe first reliable clinical practice guideline has been produced from an academic nursing organization that focuses on assessment for nursing care and incorporates the latest findings.
Beyond monoamines: II. Novel applications for PET imaging in psychiatric disorders
Authors: Royse Sarah K. , Lopresti Brian J. , Mathis Chester A. , Tollefson Savannah , Narendran Rajesh 
Published: June 2022

AbstractEarly applications of positron emission tomography (PET) in psychiatry sought to identify derangements of cerebral blood flow and metabolism. The need for more specific neurochemical imaging probes was soon evident, and these probes initially targeted the sites of action of neuroleptic (dopamine D2 receptors) and psychoactive (serotonin receptors) drugs. For nearly 30 years, the centrality of monoamine dysfunction in psychiatric disorders drove the development of an armamentarium of monoaminergic PET radiopharmaceuticals and imaging methodologies. However, continued investments in monoamine‐enhancing drug development realized only modest gains in efficacy and tolerability. As patent protection for many widely prescribed and profitable psychiatric drugs lapsed, drug development pipelines shifted away from monoamines in search of novel targets with the promises of improved efficacy, or abandoned altogether. Over this period, PET radiopharmaceutical development activities closely parallelled drug development priorities, resulting in the development of new PET imaging agents for non‐monoamine targets. In part two of this review, we survey clinical research studies using the novel targets and radiotracers described in part one across major psychiatric application areas such as substance use disorders, anxiety disorders, eating disorders, personality disorders, mood disorders, and schizophrenia. Important limitations of the studies described are discussed, as well as key methodologic issues, challenges to the field, and the status of clinical trials seeking to exploit these targets for novel therapeutics.image
Surgery and perioperative management of patients with Cushing's disease
Authors: Honegger Juergen , Nasi‐Kordhishti Isabella 
Published: June 2022

AbstractTranssphenoidal surgery (TSS) is the initial treatment modality of first choice in Cushing's disease (CD). With microscopic TSS and endoscopic TSS, two operative techniques with equally favourable remission rates and operative morbidity are available. On average, remission is achieved with primary TSS in 80% of patients with microadenomas and 60% of patients with macroadenomas. The current literature indicates that remission rates in repeat TSS for microadenomas can also exceed 70%. Experience with TSS in CD plays an important role in the success rate and centralization in Pituitary Centres of Excellence has been proposed. Microadenoma stage, imaging‐visible adenoma, confirmation of ACTH‐positive adenoma on histopathology and noninvasiveness are positive predictors for postoperative remission. In postoperative management, a steroid‐sparing protocol with early postoperative assessment of remission status is recommended. Convincing evidence suggests that prolonged postoperative prophylactic antithrombotic measures can significantly reduce the risk of postoperative thromboembolic events in CD. Prevention or successful treatment of cortisol withdrawal syndrome remains an unsolved issue that should be a focus of future research. The further development and broad availability of functional imaging hold promise for improved preoperative detection of microadenomas. Intraoperative identification of microadenomas by specific fluorescent targeting could be a promising future avenue for the treatment of patients with negative imaging.
The role of response efficacy and risk aversion in promoting compliance during crisis
Authors: Thomas Veronica L. , Mirahmad Hooman , Kemper Grace 
Published: June 2022

AbstractThis research examines consumers' compliance with behaviors that focus on preventing the spread of COVID‐19. Drawing on Protection Motivation Theory and research on efficacy, we find that, during a pandemic, consumers who have higher perceptions of response efficacy are less likely to engage in risky consumption behaviors (Study 1) and more likely to engage in protective consumption behaviors (Study 2). This effect is moderated by risk aversion, such that as risk aversion increases, COVID‐compliant behaviors increase even when consumers do not believe in their ability to effectuate change. Further, the relationship between response efficacy and COVID‐compliant behaviors is mediated by anticipated guilt. Importantly, these constructs are relevant beyond the COVID‐19 pandemic. As situations like drought, rising sea levels, and infectious diseases persist, consumers will continually be asked to sacrifice for their own wellbeing and the wellbeing of others. Thus, we discuss implications for policymakers.
MiR‐195‐5p facilitates the proliferation, migration, and invasion of human trophoblast cells by targeting FGF2
Authors: Zhou Dachun , Xu Xiaoying , Liu Yuanlin , Liu Haiyun , Cheng Xiaoyan , Gu Yannan , Xu Yuanyuan , Zhu Lingling 
Published: June 2022

AbstractBackgroundPreeclampsia (PE), the most significant adverse exposure to cardiovascular risk during pregnancy, is one of the three major factors contributing to maternal and fetal mortality and the leading cause of preterm birth. Recently, various miRNAs have been reported to participate in PE occurrence and development. Nevertheless, the regulatory impact of miR‐195‐5p in PE is still indistinct.MethodsQuantitative realtime‐PCR (qRT‐PCR), western blot, and fluorescence in situ hybridization (FISH) assay were performed to examine miR‐195‐5p and FGF2 expressions in PE serum samples or HTR‐8/SVneo and TEV‐1 cells. CCK8, flow cytometry, wound scratch, and transwell assays were conducted to determine cell viability, cycle, apoptosis, migration, and invasion. Dual‐luciferase reporter assay unveiled the relationship between miR‐195‐5p and FGF2. Migration‐related and invasion‐related protein expressions were measured by western blot assay.ResultsmiR‐195‐5p was prominently downregulated while FGF2 was increased in serum samples from PE patients and hypoxia‐treated human trophoblast cells. FGF2 was predicted as a downstream target of miR‐195‐5p and targeted association was verified by dual‐luciferase reporter assay. Functional experiments elaborated that miR‐195‐5p could facilitate trophoblast cell proliferation and metastasis but hinder cell cycle and apoptosis. Inversely, overexpressing of FGF2 could reverse the effects of miR‐195‐5p on trophoblast cell growth.DiscussionmiR‐195‐5p was decreased in PE serum samples and cell lines, serving as a potential biomarker in protecting PE exacerbation by targeting FGF2.
The social side of personality: Do affiliation and intimacy motives moderate associations of personal relationships with well‐being?
Authors: Kersten Philipp , Borschel Elisabeth , Neyer Franz J. , Mund Marcus 
Published: June 2022

AbstractBackgroundThe quantity of social relationships and social interactions is positively related to well‐being, but the underlying role of personality dispositions in these associations is unclear. The present study investigated whether social motives for affiliation and intimacy moderate associations of personal networks with well‐being.MethodWe analyzed data from N = 389 individuals living alone (aged 35–60 years) who provided self‐reports of social motives and well‐being, and who completed an ego‐centered social network task. A subsample of N = 331 individuals participated in a social network diary with daily questions about social interactions within their personal networks.ResultsOverall, we found little support for moderations. Individuals higher in affiliation felt less lonely than individuals lower in affiliation when having more frequent in‐person contact. Multilevel analyses of the diary data revealed that highly affiliative individuals reported being more satisfied than individuals lower in affiliation when having more daily social interactions than usual. No moderations were found in the context of intimacy.DiscussionFindings suggest that, especially in the context of daily social encounters, affiliation might moderate associations of social interaction quantity with well‐being. Implications for future research on personality–relationship dynamics in personal networks and daily social interactions are discussed.