bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of digital nativity on nonvolitional routine and innovative usage
Authors: Martins Patricia , Picoto Winnie Ng , Bélanger France 
Published: November 2022

PurposeThis study explores the differences between digital immigrants (DIs) and digital natives (DNs) in the continuance of routine and innovative information system use.Design/methodology/approachA quantitative survey was conducted with two different samples comprising 100 DIs and 152 DNs in mandatory information system use contexts. Data were analyzed with structural equation modeling to examine the hypothesized relationships in the research model.FindingsResults revealed differences among digital nativity groups. The effect of confirmation of expectations about system use on satisfaction is stronger for DNs whereas the effect on task–technology fit (TTF) is similar in both digital groups. Interestingly, significant differences between digital nativity groups occur in routine use. For DIs, TTF and habit are significant while for DNs, satisfaction significantly affects routine use. The results show no difference between digital native groups regarding innovative use.Originality/valueThis study extends the concept of digital nativity to routine and innovative system use, contributing to an enhanced understanding about the differences in information systems continuance (ISC) based on digital nativity. It also provides a fine-grained discussion of how to classify digital nativity and its impact in working contexts and extends the IS continuance model by considering two types of IS usage.
Toward understanding the self-efficacy of external auditors during COVID-19: empirical testing of traditional sources and virtual audit proficiency
Authors: Baatwah Saeed Rabea , Ali Al-Ansi Ali , Almoataz Ehsan Saleh , Salleh Zalailah 
Published: November 2022

Purpose
Auditors’ self-efficacy (SE) represents their level of confidence in improving their audit performance. This may be a crucial factor for auditors to perform effectively during the health crisis of COVID-19. This study aims to build on a social cognitive perspective to assess the SE of auditors during the coronavirus of 2019 (COVID-19) and to anticipate that mastery experience, verbal and social persuasion, vicarious experience, physiological and emotional states and virtual audit are determinants of auditors’ SE during COVID-19.

Design/methodology/approach
Based on data from Saudi Arabia, this study surveyed all auditors using an online questionnaire and collected 193 useful responses. Thus, this study analyzed the data using primary statistical tests and a structural equation model of partial least squares.

Findings
This study observes that auditors feel confident in their ability to perform audit activities as well during COVID-19 as at other times. This study also documents that VEs, physiological and emotional states and virtual audits play significant roles in SE. In further analyses, this study observes that auditors who are affiliated with big4 audit firms moderate the positive association between virtual audit and SE. All these results are verified under several econometrical appraisals and held constant.

Originality/value
This study provides a number of theoretical and practical implications.
Using classroom debates to elicit views on educational reforms
Authors: Hamdan Alghamdi Amani Khalaf , Aldossary Ali , Elhassan Waisi 
Published: November 2022

PurposeThis classroom-based qualitative study explored the effectiveness of the debate learning strategy in female postgraduate education in Saudi Arabia, which is implementing its recent national development plan, Vision 2030. Educational reform is key to its transition to a modernized, knowledge-based economy. The debate format was used to elicit views on educational reforms and necessitated forming and articulating well-reasoned arguments and logic.Design/methodology/approachAt a Saudi Eastern Province university, 13 female postgraduate students (preservice teachers) participated in a student-centered learning environment conducive to debates. Documents prepared for the debate underwent a qualitative content analysis.FindingsData were readily classified into five categories: educational reforms should meet 21st century skills, achieve educational outcomes, ensure Saudi Arabia’s knowledge-based economy, prioritize the role of the university and recognize the impact of both teachers and curricula. As key players in the nation’s future, participants affirmed the ongoing need for educational innovation and modernization.Originality/valueWhile debates are an authentic part of Arabian heritage, they are less utilized in Saudi higher education settings. Findings affirm that debates are a beneficial learning strategy for bolstering future educators’ participation in Saudi Arabia’s educational reform.
Contemporary challenges in the European pharmaceutical industry: a systematic literature review
Authors: Asad Arif Ibne , Popesko Boris 
Published: November 2022

PurposeThe COVID-19 pandemic creates inefficiencies in the health-care system by having devastating consequences. It has demonstrated how inefficiencies in the health system can have a significant impact on social cohesion, economic growth and public confidence in government. The main purpose of this study is to explore the contemporary challenges faced by the pharmaceutical industry in Europe.Design/methodology/approachThis study used a systematic literature review method and adopted inclusion and exclusion criteria after constructive reviews of articles from Web of Science and Scopus databases along with the ranked journals in the Chartered Association of Business Schools to search the following key terms “challenges in the European pharmaceutical industry” during the period from 2011 to 2022. The terms are set to be searched in the publications’ titles, abstracts and keywords.FindingsThis study reviewed 57 papers, and the systematic review revealed the vulnerability of the European pharmaceutical industry, such as the default patent system, ineffective research and development, debate on the role of alliances, low level of expertise in the European health-care system, pharmaceutical supply chain management and other issues.Research limitations/implicationsThis study suggests that future research may explore the challenges of multisectoral and cross-country perspectives to get a better understanding, and for the long-term sustainability of public pharmaceutical spending, new models of enhancing research investments are needed, and Europe can still play a leading role in its tradition structure within capturing innovative ideas.Practical implicationsIt provides new useful insights to policymakers, global leaders and managers to devise policies to achieve a performance-oriented culture in their institutions and firms.Social implicationsThe pharmaceutical sector has recognized the influence of social determinants of health. It moves toward sustained sound health of people to have a flourishing pharmaceutical sector.Originality/valueThere is an insufficient study on the contemporary challenges of the European pharmaceutical industry. This study presents the argument that earlier studies ignored the contemporary issues facing the European pharmaceutical industry from a comprehensive and wider angle. In addition, the COVID-19 pandemic is a recent occurrence, and it causes inefficiency in the health-care sector, where the pharmaceutical industry plays a crucial role; importantly, this topic is emerging and underresearched in the existing literature. There is also a lack of systematic literature review studies in this field.
Shape memory property of polybutylene adipate-co-terephthalate
Authors: Yu Laiming , Fu Yaqin , Dong Yubing 
Published: November 2022

Purpose
The purpose of this study is to investigate the thermomechanical condition on the shape memory property of Polybutylene adipate-co-terephthalate (PBAT). PBAT is a widely researched and rapidly developed biodegradable copolyester. In a tensile test, we found that the fractured PBAT samples had a heat-driven shape memory effect which piqued our interest, and it will lay a foundation for the application of PBAT in new fields (such as heat shrinkable film).

Design/methodology/approach
The shape memory effect of PBAT and the effect of the thermomechanical condition on its shape memory property were confirmed and systematically investigated by a thermal mechanical analyzer and tensile machine.

Findings
The results showed that the PBAT film had broad shape memory transform temperature and exhibited excellent thermomechanical stability and shape memory properties. The shape memory fixity ratio (Rf) of the PBAT films was increased with the prestrain temperature and prestrain, where the highest Rf exceeded 90%. The shape memory recovery ratio (Rr) of the PBAT films was increased with the shape memory recovery temperature and decreased with the prestrain value, and the highest Rr was almost 100%. Moreover, the PBAT films had high shape memory recovery stress which increased with the prestrain value and decreased with the prestrain temperature, and the highest shape memory recovery stress can reach 7.73 MPa.

Research limitations/implications
The results showed that PBAT had a broad shape memory transform temperature, exhibited excellent thermomechanical stability and shape memory performance, especially for the sample programmed at high temperature and had a larger prestrian, which will provide a reference for the design, processing and application of PBAT-based heat shrinkable film and smart materials.

Originality/value
This study confirmed and systematically investigated the shape memory effect of PBAT and the effect of the thermomechanical condition on the shape memory property of PBAT.
Residents’ trust in local government councils in an emerging nation: effect of political efficacy, good governance and performance
Authors: Ab. Rahman Farah Adilla , Mohd Suki Norazah , Mohd Yusof Mohd Idham , Yusof Radduan 
Published: November 2022

Purpose
This study aims to explore residents’ trust in local government councils and to examine the effect of political efficacy and good governance on that trust and on the performance of local government councils in an emerging nation.

Design/methodology/approach
Data were analysed using qualitative and quantitative research designs. Firstly, a thematic analysis was performed to explore residents’ trust in local government councils and compare it with the data gathered in the literature review. Thereafter, a partial least squares-structural equation modelling (PLS-SEM) approach was used to investigate the hypothesised linkages.

Findings
The thematic analysis of the face-to-face semi-structured interviews discovered four themes (trust, performance, political efficacy and good governance). Additional analysis of these themes via the PLS-SEM approach revealed good governance to be the most influential factor in promoting residents’ trust in local government councils. Political efficacy was the second most influential factor. Residents expect local government councils’ officers to demonstrate a strong commitment to the rule of law and comply with all relevant laws and regulations.

Practical implications
Local government councils should openly accept residents’ requests and suggestions, be more flexible in policy delivery and be responsive to policy demands given the relatively small constituencies and greater policy latitudes. Multiple avenues should be available for interaction between residents and local government councils in the mission to achieve sustainable urban growth.

Originality/value
This study is unique in that it advances existing research that is lacking in the context of the Malaysian local government council. The result alerts are crucial in that they alert local government councils to the need for high levels of governance and accountability in terms of resident support to gain more trust and confidence.
The potential for learning from good RRI practices and implications for the usefulness of RRI as an umbrella concept
Authors: Forsberg Ellen-Marie , Wittrock Christian 
Published: November 2022

Purpose
The purpose of this study is to analyze reported good institutional responsible research and innovation (RRI) practices from an organizational and learning perspective to discuss the usefulness of RRI as a broad umbrella concept.

Design/methodology/approach
This study connects neo-institutional and translation accounts of diffusion to different modes of learning and discusses reported best practices from 12 reports, including in total 23 organizations in the research system worldwide, in light of this theoretical framework. This study categorizes the good practices identified in the reports and discusses how the nature of the practices influences the potential learning from them. The authors then apply the results from the discussion of this study to current policy developments on RRI.

Findings
The two most often mentioned good practices overall are organizational policies and the establishment of organizational units, but the type of good practices recommended differs across the various aspects of the RRI umbrella concept. This diversity within the RRI construct is a practical argument against the effectiveness of RRI as an umbrella concept.

Originality/value
This study is novel in the fact that the authors, building on Wæraas (2020), systematically relate types of good practice to neo-institutional theory and translation perspectives explicitly combined with learning approaches and apply this approach in the field of research organizations. The policy implications from the empirical and theoretical analyses are novel and timely in these early phases of the EU funding framework programme Horizon Europe and can also be relevant for the increasingly important umbrella concept of Open Science.
All-inclusive holiday packages, tourist consumption and spending patterns at tourism destinations
Authors: Cozzio Claudia , Tokarchuk Oksana , Maurer Oswin 
Published: November 2022

PurposeThe purpose of this study is to investigate tourist in-destination consumption patterns in the context of bundled holiday packages in different resort categories to identify demand behavior that allows implementing profit-enhancing policies through attractive bundled offers for specific tourist segments.Design/methodology/approachThis study relies on data gathered in a quasi-experiment to analyze differences in consumption patterns at resort bars over a two-year period (summer 2018 and 2019) before and after the introduction of an all-inclusive soft drinks package.FindingsThe findings inform on bundling strategies according to different degrees of price consciousness and resort category. In particular, guests in upscale resorts are more likely to under-consume items included in a pre-paid bundle and significantly engage in additional spending than economy resort guests.Originality/valueThe quasi-experiment provides the actual in-destination consumption patterns and offering managerial insights and tools to tailor the form and content of bundles according to resort category.
Dostarlimab for recurrent mismatch repair‐deficient endometrial cancer: A cost‐effectiveness study
Authors: Dioun Shayan , Chen Ling , Melamed Alexander , Gockley Allison , St. Clair Caryn M. , Hou June Y. , Khoury‐Collado Fady , Hur Chin , Elkin Elena , Accordino Melissa , Hershman Dawn L. , Wright Jason D. 
Published: November 2022

AbstractObjectivePatients with recurrent endometrial cancer treated with carboplatin and paclitaxel whose disease progresses have few effective treatment options. Based on promising clinical trial data, the anti‐programmed cell death 1 (anti‐PD‐1) antibody dostarlimab was recently granted accelerated approval for endometrial cancer by the US Food and Drug Administration. We developed a decision model to examine the cost‐effectiveness of dostarlimab for patients with progressive/recurrent deficient mismatch repair (dMMR) endometrial cancer whose disease has progressed with first‐line chemotherapy.DesignCost‐effectiveness study.PopulationHypothetical cohort of 6000 women with progressive/recurrent dMMR endometrial cancer.MethodsThe initial decision point in the Markov model was treatment with dostarlimab, pembrolizumab or pegylated liposomal doxorubicin (PLD). Model probabilities, and cost and utility values were derived with assumptions drawn from published literature. Effectiveness was estimated as average quality‐adjusted life years (QALYs) gained. One‐way, two‐way and probabilistic sensitivity analyses were performed to vary the assumptions across a range of plausible values.Main outcome measuresThe primary outcome was the incremental cost‐effectiveness ratio (ICER).ResultsPegylated liposomal doxorubicin (PLD) was the least costly strategy, at $55,732, followed by dostarlimab ($151,533) and pembrolizumab ($154,597). Based on a willingness‐to‐pay threshold of $100,000/QALY, PLD was cost‐effective compared with dostarlimab, with an ICER of $331,913 per QALY gained for dostarlimab, whereas pembrolizumab was ruled out by extended dominance (less effective, more costly), compared with dostarlimab. In one‐way sensitivity analyses, dostarlimab was cost‐effective when its cost was reduced to $4905 (52% reduction). These results were robust in a variety of sensitivity analyses.ConclusionsDostarlimab is associated with greater survival compared with other treatments for women with recurrent dMMR endometrial cancer. Although the agent is substantially more costly, dostarlimab became cost‐effective when its cost was reduced to $5489 per cycle.
Clinical outcomes of conventional HDR intracavitary brachytherapy combined with complementary applicator‐guided intensity modulated radiotherapy boost in patients with bulky cervical tumour
Authors: Lu Shun , Wang Shubin , Kim Robert Y. , Zhang Jiayu , Wang Xianliang , Wang Weidong , Zhu Guiquan , Zhou Jie , Tan Yan , Tan Mingyu , Li Minglun , Yin Gang , Li Jie , Feng Mei , Lang Jinyi 
Published: November 2022

AbstractObjectiveTo investigate the clinical outcomes and toxicity in patients with locally advanced cervical cancer treated with supplementary applicator guided‐intensity modulated radiation therapy (IMRT) based on conventional intracavitary brachytherapy (IC/IMRT).DesignA retrospective cohort study.SettingSichuan Cancer Hospital & Institute, Sichuan Cancer Centre, China.PopulationLarge high‐risk clinical target volume (HR‐CTV) volume (>40 ml) at the time of brachytherapy cervical cancer patients were recruited.MethodsThis study is a retrospective analysis of 76 patients with locally advanced cervical cancer (FIGO IIB‐IVA) treated with concurrent chemoradiotherapy followed by IC/IMRT between June 2010 and October 2016. External radiotherapy (45 Gy in 25 fractions) was adminstered with cisplatin chemotherapy treatment before IC/IMRT. The IMRT plan was optimised using the ICBT plan base dose plan by an inverse dose optimisation tool which allows the use of DVH constraints on the total dose of ICBT. A seven‐field gantry angle IMRT plan was devised to avoid hotspots when optimising the boost plan. The prescription dose for HR‐CTV and IR‐CTV were 6 and 5 Gy per fraction for five fractions, respectively.ResultsMean HR‐CTV was 65.8 ± 23.6 ml at the time of brachytherapy. D90 for HR‐CTV and IR‐CTV were 88.7 ± 3.6 Gy and 78.1 ± 2.5 Gy. D2cc for bladder, rectum, sigmoid and small intestine were 71.8 ± 3.8, 64.6 ± 4.9, 63.9 ± 5.3 and 56.7 ± 8.7 Gy, respectively. Median follow‐up was 85 months (47.9–124.2 months). Five‐year local recurrence‐free survival rate, metastasis recurrence‐free survival rate, disease‐free survival rate and cancer‐special survival rate were 87.6, 82.4, 70.9 and 76.3%, respectively. The grade 1 + 2 gastrointestinal and urinary late toxicities were 15.8 and 21.1%, and grade 3 late toxicities were 3.9 and 5.2%, respectively. Neither acute nor late grade 4 gastrointestinal or urinary toxicities were seen.ConclusionsThe combination of ICBT with an applicator‐guided supplementary IMRT boost achieved excellent local control and overall survival with low toxicity for bulky residual cervical tumour.
High‐pressure pasteurization of low‐acid chilled ready‐to‐eat food
Authors: Inanoglu Sumeyye , Barbosa‐Cánovas Gustavo V. , Sablani Shyam S. , Zhu Mei‐Jun , Keener Larry , Tang Juming 
Published: November 2022

AbstractThe working population growth
have created greater consumer demand for ready‐to‐eat (RTE) foods. Pasteurization is one of the most common preservation methods for commercial production of low‐acid RTE cold‐chain products. Proper selection of a pasteurization method plays an important role not only in ensuring microbial safety but also in maintaining food quality during storage. Better retention of flavor, color, appearance, and nutritional value of RTE products is one of the reasons for the food industry to adopt novel technologies such as high‐pressure processing (HPP) as a substitute or complementary technology for thermal pasteurization. HPP has been used industrially for the pasteurization of high‐acid RTE products. Yet, this method is not commonly used for pasteurization of low‐acid RTE food products, due primarily to the need of additional heating to thermally inactivate spores, coupled with relatively long treatment times resulting in high processing costs.Practical Application: Food companies would like to adopt novel technologies such as HPP instead of using conventional thermal processes, yet there is a lack of information on spoilage and the shelf‐life of pasteurized low‐acid RTE foods (by different novel pasteurization methods including HPP) in cold storage. This article provides an overview of the microbial concerns and related regulatory guidelines for the pasteurization of low‐acid RTE foods and summarizes the effects of HPP in terms of microbiology (both pathogens and spoilage microorganisms), quality, and shelf‐life on low‐acid RTE foods. This review also includes the most recent research articles regarding a comparison between HPP pasteurization and thermal pasteurization treatments and the limitations of HPP for low‐acid chilled RTE foods.
Can MASCC and CISNE scores predict delays of lung cancer chemotherapy after febrile neutropenia?
Authors: Ono Yoshitaka , Hayama Naoki , Hattori Shigeaki , Ito Yoko , Oguma Tsuyoshi , Sakamaki Fumio , Asano Koichiro 
Published: November 2022

AbstractBackgroundFebrile neutropenia (FN) during cancer chemotherapy can lead to morbidity and mortality. The Multinational Association of Supportive Care in Cancer (MASCC) and clinical index of stable febrile neutropenia (CISNE) scores have been widely used to predict the risk of severe medical complications in patients with FN; however, there are few tools for predicting chemotherapy delays or discontinuation after FN.MethodsPatients admitted to two university hospitals between 2014 and 2018 with a FN diagnosis during the first cycle of chemotherapy for lung cancer were reviewed retrospectively.ResultsAmong 539 patients who received 813 courses of chemotherapy for lung cancer, 49 (9%) developed FN during the first treatment cycle. Although all the patients recovered from their primary infection, 19 patients (38.8%) developed serious medical complications, 11 (22.4%) were unable to resume chemotherapy and one (2.0%) declined to resume chemotherapy, and nine (18.4%) died within 90 days. Patients who failed to resume chemotherapy had a lower MASCC score (median 8.5 vs. 17, p < 0.01) and a higher CISNE score (median 3 vs. 1, p < 0.01) at the onset of FN. The specificity to predict the patient who failed to resume chemotherapy was 90% or more with MASCC score ≤9 or CISNE score ≥3, with the sensitivity of 61%. MASCC score ≤ 16 can also be a sensitive indicator with the sensitivity and specificity of 89 and 52%, respectively.ConclusionThe MASCC and CISNE scores are useful in identifying lung cancer patients who are unable to resume chemotherapy as scheduled after the onset of FN.