bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Supercritical CO2 With Water as Geofluid in Geothermal Reservoirs With Numerical Investigation Using Fully Coupled Thermo-Hydro-Geomechanical Model
Authors: Gudala Manojkumar , Govindarajan Suresh Kumar , Yan Bicheng , Sun Shuyu 
Published: September 2022

Abstract
In the present work, fully coupled dynamic thermo-hydro-mechanical (THM) model was employed to investigate the advantage and disadvantages of supercritical CO2 (SCCO2) over water as geofluids. Low-temperature zone was found in both SCCO2-enhanced geothermal system (EGS) and water-EGS systems, but spatial expansion is higher in water-EGS. Although, the spatial expansion of SCCO2 into the rock matrix will help in the geo-sequestration, the expansion of stress and strain invaded zones were identified significantly in the vicinity of fracture and injection well. SCCO2-EGS system is giving better thermal breakthrough and geothermal life conditions compared to the water-EGS system. Reservoir flow impedance (RFI) and heat power are examined, and heat power is high in the water-EGS system. Minimum RFI is found in the SCCO2-EGS system at 45 °C and 0.05 m/s. Maximum heat power for SCCO2-EGS was observed at 35 °C, 20 MPa, and 0.15 m/s. Therefore, the developed dynamic THM model is having greater ability to examine the behavior of SCCO2-EGS and water-EGS systems effectively. The variations occur in the rock matrix, and the performance indicators are dependent on the type of fluid, injection/production velocities, initial reservoir pressure, and injection temperature. The advantages of SCCO2-EGS system over the water-EGS system provide a promising result to the geothermal industry as a geofluid.
Reducing low-value care: what can we learn from eight de-implementation studies in the Netherlands?
Authors: Verkerk Eva W , van Dulmen Simone A , Westert Gert P , Hooft Lotty , Heus Pauline , Kool Rudolf B 
Published: September 2022

BackgroundReducing the overuse of care that is proven to be of low value increases the quality and safety of care. We aimed to identify lessons for reducing low-value care by looking at: (1) The effects of eight de-implementation projects. (2) The barriers and facilitators that emerged. (3) The experiences with the different components of the projects.MethodsWe performed a process evaluation of eight multicentre projects aimed at reducing low-value care. We reported the quantitative outcomes of the eight projects on the volume of low-value care and performed a qualitative analysis of the project teams’ experiences and evaluations. A total of 40 hospitals and 198 general practitioners participated.ResultsFive out of eight projects resulted in a reduction of low-value care, ranging from 11.4% to 61.3%. The remaining three projects showed no effect. Six projects monitored balancing measures and observed no negative consequences of their strategy. The most important barriers were a lack of time, an inability to reassure the patient, a desire to meet the patient’s wishes, financial considerations and a discomfort with uncertainty. The most important facilitators were support among clinicians, knowledge of the harms of low-value care and a growing consciousness that more is not always better. Repeated education and feedback for clinicians, patient information material and organisational changes were valued components of the strategy.ConclusionsSuccessfully reducing low-value care is possible in spite of the powerful barriers that oppose it. The projects managed to recruit many hospitals and general practices, with five of them achieving significant results without measuring negative consequences. Based on our findings, we offer practical recommendations for successfully reducing low-value care.
Determining the feasibility of exercise therapy and activity modification for treating adolescents with heel pain: a study protocol
Authors: Hanlon Shawn L , Bley Bradley C , Silbernagel Karin Grävare 
Published: September 2022

Calcaneal apophysitis and Achilles tendinopathy are common overuse injuries characterised by insidious posterior heel pain with activity. Calcaneal apophysitis is commonly diagnosed in adolescents, although Achilles tendinopathy is understudied in the adolescent population and is therefore rarely considered until adulthood. Exercise therapy and activity modification have the highest level of evidence for treating Achilles tendinopathy, while calcaneal apophysitis is treated with anecdotal and passive treatment or complete rest. It remains unknown whether exercise therapy is effective for adolescents with heel pain related to either diagnosis.This is a pilot and feasibility study. Thirty participants between the ages of 7 years and 17 years with posterior heel pain will be recruited from the local community and club sports team and local physicians, school nurses, and athletic trainers through flyers and social media. Participants will be asked to complete evaluations and treatment sessions every 4 weeks with three virtual visits every 2 weeks in between for 12 weeks. All participants will receive standardised treatment consisting of daily Achilles tendon loading exercises and education on pain-guided activity modification. Feasibility outcomes will include recruitment, enrolment, retention and compliance. Clinical outcomes will include the measures of symptom severity, quality of life, tendon morphology and lower extremity function.This protocol will provide preliminary data to inform a larger clinical trial based on the feasibility of the proposed intervention and methodology. Additionally, the results will provide preliminary evidence on whether Achilles tendon injury occurs in the adolescent population.The trial is registered with clinicaltrials.gov (ID:1652996).
Genotype–phenotype correlations and clinical outcomes of patients with von Hippel-Lindau disease with large deletions
Authors: Zhang Kenan , Yang Wuping , Ma Kaifang , Qiu Jianhui , Li Lei , Xu Yawei , Zhang Zedan , Yu Chaojian , Zhou Jingcheng , Gong Yanqing , Cai Lin , Gong Kan 
Published: September 2022

BackgroundApproximately 20%–40% of patients with von Hippel-Lindau (VHL) disease, an autosomal dominant hereditary disease, exhibit large deletions (LDs). Few studies have focused on this population. Hence, we aimed to elucidate the genotype–phenotype correlations and clinical outcomes in VHL patients with LDs.MethodsIn this retrospective study, we included 119 patients with VHL disease from 50 unrelated families in whom LDs were detected using traditional and next-generation sequencing methods. Other germline mutations were confirmed by Sanger sequencing. Genotype–phenotype correlations and survival were analysed in different groups using Kaplan-Meier and Cox regression. We also evaluated therapeutic response to tyrosine kinase inhibitor (TKI) therapy.ResultsThe overall penetrance of patients aged <60 was 95.2%. Two VHL patients with LDs also carriedCHEK2andFLCNgermline mutations. An earlier age of onset of retinal haemangioblastoma was observed in the next generation. Patients with exon 2 deletion ofVHLhad an earlier onset age of renal cell carcinoma and pancreatic lesions. The risk of renal cell carcinoma was lower in VHL patients with LDs and aBRK1deletion. The group with earlier age of onset received poorer prognosis. Four of eight (50%) patients showed partial response to TKI therapy.ConclusionThe number of generations and the status of exon 2 could affect age of onset of VHL-related manifestations. Onset age was an independent risk factor for overall survival. TKI therapy was effective in VHL patients with LDs. Our findings would further support clinical surveillance and decision-making processes.
Triple therapy versus dual-antiplatelet therapy for dolichoectatic vertebrobasilar fusiform aneurysms treated with flow diverters
Authors: Siddiqui Adnan H , Monteiro Andre , Hanel Ricardo A , Kan Peter , Mohanty Alina , Cortez Gustavo M , Rabinovich Margarita , Matouk Charles , Sujijantarat Nanthiya , Romero Charles , Stone Jeremy , Ebersole Koji , Fry Lane , Natarajan Sabareesh K , Owusu-Adjei Brittany , Ortega-Gutierrez Santiago , Vivanco-Suarez Juan , Wakhloo Ajay K , Levy Elad I 
Published: September 2022

BackgroundDolichoectatic vertebrobasilar fusiform aneurysms (DVBFAs) have poor natural history when left untreated and high morbimortality when treated with microsurgery. Flow diversion (FD) with dual-antiplatelet therapy (DAPT) is feasible but carries high risk of perforator occlusion and progression of brainstem compression. Elaborate antithrombotic strategies are needed to preserve perforator patency while vessel remodeling occurs. We compared triple therapy (TT (DAPT plus oral anticoagulation)) and DAPT alone in patients with DVBFAs treated with FD.MethodsRetrospective comparison of DAPT and TT in patients with DVBFAs treated with FD at eight US centers.ResultsThe groups (DAPT=13, TT=14) were similar in age, sex, clinical presentation, baseline disability, and aneurysm characteristics. Radial access use was significantly higher in the TT group (71.4% vs 15.3%; P=0.006). Median number of flow diverters and adjunctive coiling use were non-different between groups. Acute ischemic stroke rate during the oral anticoagulation period was lower in the TT group than the DAPT group (7.1% vs 30.8%; P=0.167). Modified Rankin Scale score decline was significantly lower in the TT group (7.1% vs 69.2%; P=0.001). Overall rates of hemorrhagic complications (TT, 28.6% vs DAPT, 7.7%; P=0.162) and complete occlusion (TT, 25% vs DAPT, 54.4%; P=0.213) were non-different between the groups. Rate of moderate-to-severe disability at last follow-up was significantly lower in the TT group (21.4% vs 76.9%; P=0.007).ConclusionsPatients with DVBFAs treated with FD in the TT group had fewer ischemic strokes, less symptom progression, and overall better outcomes at last follow-up than similar patients in the DAPT group.
Differences in COVID-19 vaccination coverage by occupation in England: a national linked data study
Authors: Nafilyan Vahe , Dolby Ted , Finning Katie , Pawelek Piotr , Edge Rhiannon , Morgan Jasper , Glickman Myer , Pearce Neil , van Tongeren Martie 
Published: September 2022

BackgroundMonitoring differences in COVID-19 vaccination uptake in different groups is crucial to help inform the policy response to the pandemic. A key data gap is the absence of data on uptake by occupation. This study investigates differences in vaccination rates by occupation in England, using nationwide population-level data.MethodsWe calculated the proportion of people who had received three COVID-19 vaccinations (assessed on 28 February 2022) by detailed occupational categories in adults aged 18–64 and estimated adjusted ORs to examine whether these differences were driven by occupation or other factors, such as education. We also examined whether vaccination rates differed by ability to work from home.ResultsOur study population included 15 456 651 adults aged 18–64 years. Vaccination rates differed markedly by occupation, being higher in health professionals (84.7%) and teaching and other educational professionals (83.6%) and lowest in people working in elementary trades and related occupations (57.6%). We found substantial differences in vaccination rates looking at finer occupational groups. Adjusting for other factors likely to be linked to occupation and vaccination, such as education, did not substantially alter the results. Vaccination rates were associated with ability to work from home, the rate being higher in occupations which can be done from home. Many occupations with low vaccination rates also involved contact with the public or with vulnerable peopleConclusionsIncreasing vaccination coverage in occupations with low vaccination rates is crucial to help protecting the public and control infection. Efforts should be made to increase vaccination rates in occupations that cannot be done from home and involve contact with the public.
Predictions on global properties in O+O collisions at the Large Hadron Collider using a multi-phase transport model
Authors: Behera Debadatta , Mallick Neelkamal , Tripathy Sushanta , Prasad Suraj , Mishra Aditya Nath , Sahoo Raghunath 
Published: September 2022

AbstractOxygen ($$^{16}$$

16

O) ions are planned to be injected at the Large Hadron Collider (LHC) in its next runs, and a day of physics run is anticipated for O+O collisions at $$\sqrt{s_\mathrm{{NN}}}$$

s
NN

= 7 TeV. As the system size of O+O collisions has the final state multiplicity overlap with those produced in pp, p+Pb and Pb+Pb collisions, the study of global properties in O+O collisions may provide a deeper insight into the heavy-ion-like behavior observed in small collision systems and its similarities/differences with a larger system like Pb+Pb collisions. In the present work, we report the predictions for global properties in O+O collisions at $$\sqrt{s_\mathrm{{NN}}}$$

s
NN

= 7 TeV using a multi-phase transport model (AMPT). We report the mid-rapidity charged-particle multiplicity, transverse mass, Bjorken energy density, pseudo-rapidity distributions, squared speed of sound, transverse momentum ($$p_\mathrm{T}$$

p
T

) spectra, the kinetic freeze-out parameters, and $$p_\mathrm{T}$$

p
T

-differential particle ratio as a function of collision centrality. Further, we have studied the transverse momentum-dependent elliptic flow of charged particles. The results are shown for Woods-Saxon and harmonic oscillator nuclear density profiles. In addition, we have compared the results with an $$\alpha $$
α
-clustered structure incorporated inside the oxygen nucleus. Average charged-particle multiplicity and the Bjorken energy density show a significant increase in most central collisions for the harmonic oscillator density profile, while other global properties show less dependence on the density profiles considered in this work. The results from the $$\alpha $$
α
-clustered structure incorporated inside the oxygen nucleus show similar initial energy density and final charged-particle multiplicity as observed for the harmonic oscillator density profile.
Geuine tripartite entanglement in three-flavor neutrino oscillations
Authors: Li Yu-Wen , Li Li-Juan , Song Xue-Ke , Wang Dong , Ye Liu 
Published: September 2022

AbstractThe violation of Leggett–Garg inequalities tested the quantumness of neutrino oscillations (NOs) across macroscopic distances. The quantumness can be quantified by using the tools of the quantum resource theories. Recently, a new genuine tripartite entanglement measure (Xie et al. in Phys Rev Lett 127:040403, 2021), concurrence fill, is defined as the square root of the area of the concurrence triangle satisfying all genuine multipartite entanglement conditions. It has several advantages compared to other existing tripartite measures. Here, we focus on using concurrence fill to quantify the tripartite entanglement in three-flavor NOs. Concurrence fill can reach its maximum 0.89 for the experimentally-observed electron antineutrino oscillations, but it cannot for the muon antineutrino oscillations. In both cases, we compare its performance with other three tripartite entanglement measures, including the generalized geometric measure (GGM), the three-$$\pi $$πentanglement, and the genuinely multipartite concurrence (GMC), in the neutrino propagation, and accordingly show that concurrence fill contains the most quantum resource. Furthermore, concurrence fill and the three-$$\pi $$πentanglement are always smooth, while GGM and GMC measures have several sharp peaks. The genuine tripartite quantification of the quantumness of three-flavor NOs represents the first step towards the further potential application of neutrinos on quantum information processing.
On finite time singularities in scalar field dark energy models based in the RS-II Braneworld
Authors: Trivedi Oem , Khlopov Maxim 
Published: September 2022

AbstractThe quest of deciphering the true nature of dark energy has proven to be one of the most exciting in recent times in cosmology. Various ideas have been put forward in this regard besides the usual cosmological constant approach, ranging from scalar field based models like Quintessence and Phantom dark energy to various modified gravity approaches as well. A very interesting idea then is to consider scalar field dark energy models in quantum gravitationally corrected cosmologies with the RS-II Braneworld being one of the most well known in this regard. So in this work, we consider RS-II Braneworld based scalar field dark energy models and try to look out for the existence of finite time singularities in these regimes both through a dynamical system perspective, for which we employ the Goriely–Hyde singularity analysis method, and a physical perspective. Our approach is general in the sense that it is not limited to any particular class of potentials or for any constrained parameter region for the brane tension and is valid for both Quintessence and phantom dark energy regimes. We firstly show through Goriely–Hyde procedure that finite time singularities can exist in these models for a limited set of initial conditions and that this result would hold irrespective of any consideration given to the swampland dS conjecture. We then discuss the physical nature of the singularities that can occur in this regime, where we use a well motivated ansatz for the Hubble parameter and show that these models of dark energy can allow for weak singularities like those of Type III and Type IV and can also allow for strong singularities like the Big Rip (Type I).
Excited Q-balls
Authors: Almumin Yahya , Heeck Julian , Rajaraman Arvind , Verhaaren Christopher B. 
Published: September 2022

AbstractComplex scalars in U(1)-symmetric potentials can form stable Q-balls, non-topological solitons that correspond to spherical bound-state solutions. If the U(1) charge of the Q-ball is large enough, it can support a tower of unstable radial excitations with increasing energy. Previous analyses of these radial excitations were confined to fixed parameters, leading to excited states with different charges Q. In this work, we provide the first characterization of the radial excitations of solitons for fixed charge, providing the physical spectrum for such objects. We also show how to approximately describe these excited states analytically and predict their global properties such as radius, energy, and charge. This enables a complete characterization of the radial spectrum. We also comment on the decay channels of these excited states.
LITAR
Authors: Zhao Yiqin , Ma Chongyang , Huang Haibin , Guo Tian 
Published: September 2022

An accurate understanding of omnidirectional environment lighting is crucial for high-quality virtual object rendering in mobile augmented reality (AR). In particular, to support reflective rendering, existing methods have leveraged deep learning models to estimate or have used physical light probes to capture physical lighting, typically represented in the form of an environment map. However, these methods often fail to provide visually coherent details or require additional setups. For example, the commercial framework ARKit uses a convolutional neural network that can generate realistic environment maps; however the corresponding reflective rendering might not match the physical environments. In this work, we present the design and implementation of a lighting reconstruction framework called LITAR that enables realistic and visually-coherent rendering. LITAR addresses several challenges of supporting lighting information for mobile AR.
First, to address the spatial variance problem, LITAR uses two-field lighting reconstruction to divide the lighting reconstruction task into the spatial variance-aware near-field reconstruction and the directional-aware far-field reconstruction. The corresponding environment map allows reflective rendering with correct color tones. Second, LITAR uses two noise-tolerant data capturing policies to ensure data quality, namely guided bootstrapped movement and motion-based automatic capturing. Third, to handle the mismatch between the mobile computation capability and the high computation requirement of lighting reconstruction, LITAR employs two novel real-time environment map rendering techniques called multi-resolution projection and anchor extrapolation. These two techniques effectively remove the need of time-consuming mesh reconstruction while maintaining visual quality. Lastly, LITAR provides several knobs to facilitate mobile AR application developers making quality and performance trade-offs in lighting reconstruction. We evaluated the performance of LITAR using a small-scale testbed experiment and a controlled simulation. Our testbed-based evaluation shows that LITAR achieves more visually coherent rendering effects than ARKit. Our design of multi-resolution projection significantly reduces the time of point cloud projection from about 3 seconds to 14.6 milliseconds. Our simulation shows that LITAR, on average, achieves up to 44.1% higher PSNR value than a recent work Xihe on two complex objects with physically-based materials.
Identification and Extraction of Features from Malayalam Poems for Analyzing Syllable Duration Patterns
Authors: M P Jasir , Balakrishnan Kannan 
Published: September 2022

Text-to-speech (TTS) synthesis is an active area of research to generate synthetic speech from the underlying text. Compared to English and many European languages, TTS is yet to mature in Malayalam, the principal language of the South Indian state of Kerala. A syllable has to be uttered with proper durational and prosodic characteristics to emulate natural speech. When it comes to poems in Malayalam, many of them have an inherent rhythm attached to them. In Malayalam, this property is characterized by the Vruta [28] in which the poem is written. Vruta decides the meter of narration of the poem. Therefore, it is only consequential that Vruta can give away vital cues about the durational and prosodic characteristics of the poem verses recited. This study intends to identify the features that determine the durational characteristics of a poem written in a particular Vruta and develop an algorithm to extract those features required to build a dataset to model the duration of syllable utterances for tuneful TTS in Malayalam. Poems written in three Vrutas, namely Kakali, Manjari, and Keka, are considered in this study. Nineteen extractible features from the orthographic representation of a poem are identified for this purpose. A standard dataset is built using these extracted features. Later, support vector machine and feed forward neural network based estimators are proposed to model the duration of Malayalam poem syllables for tuneful speech synthesis. The hyperparameters are optimized using the GridsearchCV algorithm from the Scikit-learn machine learning library [15].