bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initial operation of perpendicular line-of-sight compact neutron emission spectrometer in the large helical device
Authors: Sangaroon S. , Ogawa K. , Isobe M. 
Published: September 2022

The perpendicular line-of-sight compact neutron emission spectrometer (perpendicular CNES) was newly installed to understand the helically trapped fast-ion behavior through deuterium–deuterium (D–D) neutron energy spectrum measurement in the Large Helical Device (LHD). The energy calibration of the EJ-301 liquid scintillation detector system for perpendicular CNES was performed on an accelerator-based D–D neutron source. We installed two EJ-301 liquid scintillation detectors, which view the LHD plasma vertically from the lower side through the multichannel collimator. The D–D neutron energy spectrum was measured in a deuterium perpendicular-neutral-beam-heated deuterium plasma. By the derivative unfolding technique, it was found that the D–D neutron energy spectrum had a double-humped shape with peaks at ∼2.33 and ∼2.65 MeV. D–D neutron energy spectrum was calculated based on the fast ion distribution function using guiding center orbit-following models considering the detector’s energy resolution. The calculated peak energies in the D–D neutron energy spectrum almost match the experiment. In addition, a feasibility study toward the measurement of the energy distribution of ion-cyclotron-range-of-frequency-wave-accelerated beam ions was performed.
A three-layered typology for the subtitling of taboo
Authors: Xavier Catarina 
Published: September 2022

Abstract
The translation of taboo words has attracted scholars’ interest in studying it in the audiovisual context over the
last decades. The surge of research on this predominant form of translation in everyday life has brought to light the
communicative, pragmatic, and semiotic aspects as well as the technical constraints for subtitling taboo words. Previous research
has primarily taken a quantitative method, discussed issues that justify their results, and suggested possible outcomes from a
potential receiver’s point of view. While contributing to existing related literature, this paper argues that there is a need for
a thorough, detailed examination of translation options in subtitling taboo words. The paper presents a three-layered typology of
methods, strategies, and techniques, which provides a comprehensive description of audiovisual translators’ options. Following a
bottom-up/top-down approach, the proposed typography is then put to the test in a corpus-based case study comprising six movies
and their professional subtitles broadcast on Portuguese televisions.
Task-modality effects on young learners’ language-related episodes in collaborative dialogue
Authors: Gallardo-del-Puerto Francisco , Martínez-Adrián María 
Published: September 2022

Abstract
In adult learners’ collaborative dialogue, oral+written tasks have been found to promote a greater incidence and
resolution of language-related episodes and to demand higher levels of accuracy than oral tasks thanks to the extra time learners
have to reflect on their written outcome. No previous studies have tested whether asking learners to attend to accuracy in both
modalities would yield similar results. The present study with 23 dyads of young English learners supports the superiority of the
oral+written modality in the promotion of learning opportunities, even if learners are encouraged to focus on form in the oral
modality, a result reinforced by the incorporation of target-like resolved episodes in the written product. However, the
intragroup analysis reveals that young learners focus on meaning in equal terms, present low rates of target-likeness, and do not
elaborate their resolutions, all of which can be ascribed to their younger age and developing metalinguistic awareness.
The SrS doped with Cl and K: a promising ambipolar semiconductor for transparent electronics application
Authors: Chen Yu , Fan S W , Gao G Y 
Published: September 2022

Abstract
Wide-gap semiconductors are essential for current optoelectronics due to the good conductivity and transparency. Although the significant successes have been achieved for n-type transparent conducting materials (TCMs), the p-type TCMs seriously lag behind the n-type counterparts, which severely hinder the developments of the high-performance transparent electronic devices. In present work, we predict the transparent ambipolar conducting can be obtained in SrS by utilizing the hybrid functional method. The Cl substituting S and K substituting Sr (labeled as ClS and KSr) are typical shallow donor and acceptor defects. Compared to conduction band minimum (valence band maximum), the ionization energies for ClS (KSr) would converge to 0.02 (0.14) eV. Using the equilibrium fabricate method, the free electrons (holes) density can reach 1.24 × 1019 cm−3 (1.23 × 1018 cm−3) at room temperature. The effective masses for electron and hole are 0.32 and 0.87 m
0 (m
0 is the mass of a free electron). In the visible light regions, the high transparency can be kept due to its weak inter-band and intra-band absorptions as well as the negligible plasmonic effect. High density of carriers, smaller effective mass and high transparency show SrS doped with Cl and K is a promising ambipolar transparent semiconductor. This work provides insights to realize the high performance ambipolar TCMs. Once the excellent ambipolar TCMs is explored, the high-performance transparent devices are expected in the future.
The role of interfacial intermixing on HAMR dynamics in bilayer media
Authors: Meo A , Chureemart P , Chantrell R W , Chureemart J 
Published: September 2022

Abstract
We use an atomistic spin model to simulate FePt-based bilayers for heat assisted magnetic recording (HAMR) devices and investigate the effect of various degrees intermixing that might arise throughout the fabrication, growth and annealing processes, as well as different interlayer exchange couplings, on HAMR magnetisation dynamics. Intermixing can impact the device functionality, but interestingly does not deteriorate the properties of the system. Our results suggest that modest intermixing can prove beneficial and yield an improvement in the magnetisation dynamics for HAMR processes, also relaxing the requirement for weak exchange coupling between the layers. Therefore, we propose that a certain intermixing across the interface could be engineered in the fabrication process to improve HAMR technology further.
Determining the complex refractive index from two discrete angles in the specular reflectance profile of p polarized light
Authors: Koutsoumpos Spyridon , Giannios Panagiotis , Moutzouris Konstantinos 
Published: September 2022

Abstract
Upon illumination with p polarized light, the reflectance profile at an interface between a front transparent and a rear attenuating medium contains two characteristic angles that can be measured with sufficient accuracy by use of common laser refractometers. We propose a simple method to determine the complex optical constants of attenuating samples from these two discrete angles, namely, the critical angle of attenuated total reflection and the pseudo-Brewster angle.
Digital twin based condition monitoring approach for rolling bearings
Authors: Guo Liang , Zong Zhuyuxiu , Zhang Ruiqi , Gao Hongli , Li Guihao , Cheng Zhe 
Published: September 2022

Abstract
Digital twin is an important technology for grasping states of mechanical systems in real time. However, there are few studies on how to establish life-cycle digital twin models of bearings. In order to accurately estimate the condition of bearings, a digital twin model of bearing life cycle (BLDT) is proposed to achieve equivalent information on the virtual entity (VE) model and physical entity (PE) model. First, a dynamic model of rolling bearings and defect evolution model are established to simulate the dynamic response of the bearing performance degradation process. Then, the physical characteristics and degradation information of the PE model are exchanged with the VE model to evaluate the time-varying defect size and the equivalent comprehensive stiffness. The evolution law of the life-cycle is obtained through a neural network. Finally, the network parameters are introduced into the VE model to obtain dynamic response results of the life-cycle bearing dynamic model of other datasets under the same working conditions. By comparing the obtained digital twin results with experiment signals in the time and frequency domains, the accuracy and effectiveness of the BLDT model are verified.
The Power of Visualization – Instilling Safety Excellence in Multinational Workforces at Wind Farm Construction Sites
Authors: Nienhaus A , Widdes J 
Published: September 2022

Abstract
The construction of wind farms involves a mixture of – often centrally deployed – highly specialized experts and local resources depending on the type of activity. The common denominator is that crews are increasingly multinational. For the prevention of accidents and adverse impacts, safety requirements have to be communicated to the workforce in a form which is adequate to the workforce composition and easy to deploy to remote worksites. Field work performed by the authors indicates that visual and/or digital tools for effective safety communication are not yet widely employed, and many field safety trainings and toolbox talks rely on written communication of rules with often repetitive content and no checks of effectiveness. Ways of effective field safety communication are analysed and an approach is presented for enhancing in-the-field conversations and toolbox talks for field sites with limited access to digital learning tools. Simple and easy-to-deploy visuals will remain to be important in-the-field aids for safety communication in remote areas, even as advanced immersive training methods become increasingly available. Any tools should be designed for or should be adaptable to the composition of workforces in terms of language skills, workers qualifications and demographic aspects such as age or diversity. Lastly, field safety communication and training should always be accompanied by personal interactions between workers and supervisors and/or peer multipliers to highlight the “why” behind safety, i.e. the role of every single individual for providing a sound and healthy operating environment and ultimately protecting human lives.
The new Italian Wind Atlas - Atlante EOLico ItaliANo (AEOLIAN)
Authors: Sperati Simone , Alessandrini Stefano , Cheng Will , Airoldi Davide , Amaranto Alessandro , Bonanno Riccardo , Lacavalla Matteo 
Published: September 2022

Abstract
Recent developments in terms of meteorological models and wind generation technologies call for an improved representation of the spatiotemporal variability of the wind conditions, in order to efficiently support strategic planning at the national scale.
To do so, we have developed the new Italian Wind Atlas – Atlante EOLico ItaliANo (AEOLIAN), building upon its previous release at the beginning of the century, with the main goal of supporting the operators in planning the future wind generation, in accordance with the ambitious targets set for 2030 by the EU Green Deal (over 20 GW of installed onshore wind power, plus about 3 GW offshore).
The new database is the results of a collaboration effort between Ricerca sul Sistema Energetico (RSE) SpA and the National Center for Atmospheric Research (NCAR), which jointly developed a novel approach combining Weather Research and Forecasting (WRF) based numerical weather modeling with the Analog Ensemble (AnEn) statistical technique.
To create the atlas, model simulations have been initially carried out at hourly time-step over the 1990-2019 period with a horizontal resolution of 4 km, nesting a 1.33 km inner grid only for the 2015-2019 period. AnEn is then employed to extend in the past the 5 high-resolution years, creating a 30-year dataset which embeds the whole country, including the marine areas.
Compared to similar products currently available, the new Atlas provides higher horizontal resolution and enhanced accuracy, thanks to the assimilation of the observational wind data of the Italian regional weather network in the simulations.
Preliminary results are shown here by comparing AEOLIAN with other atlases recently developed at international level such as the New European Wind Atlas (NEWA), and by highlighting the differences with respect to the original Italian Wind Atlas. Some derived parameters of particular interest for the operators are also featured and shown, such as wind power density.
Digital Twin solutions to historical building stock maintenance cycles
Authors: Rosa F 
Published: September 2022

Abstract
The purpose of this work is to provide a framework for the vulnerability of traditional historical buildings. Buildings that are not constrained and do not have a design obligation for minor energy retrofit interventions. The digitization of the construction sector can help to design interventions with Digital Twin methodologies that can be integrated into a single document that collects them as the Digital Building Logbook. We propose a definition of an innovative workflow that defines integrations and technological innovations in the historical building stock. In this work are presented operational proposals to ensure and increase the protection and conservation of the Italian historical building stock, trying to strengthen the activities of designers and companies for the reduction of seismic vulnerability in case of maintenance or energy retrofit.
Smart Storage the Key factor of Energy Transition
Authors: Zingales Antonio 
Published: September 2022

Abstract
When it comes to evaluate the next-gen Energy Transition, it turns out there are so many new elements in the power grid that it’s hard to pick one as the k-factor. There is, however, one grid element that has been getting a great deal of next-gen interest: energy storage because it is the critical element for making wind and solar more grid friendly.
Storage can be managed with smart characteristics (Digitally Smart EMS) able to solve problems of the grid, but to become profitable for investors, the local regulatory frame is to be considered.
Today in the path to net zero emission, Storage is applied in the range of 1 to 4 h duration, but for the next step (to 70%, 100% RES) Energy Intensive Storage will become more relevant and LDES (Long Duration Energy Storage) will be necessary for the System. Because of this, we can say that Energy Storage System: digitally smart (for managing grid and revenues requirements), with proactive Regulatory frame (transparent for anticipating investment), with LDES option (Long Duration Energy Storage) technologically available – It can really be the key factor of Energy Transition and to drive the Net Zero agenda, see Fig.1.
Physical compatibility of remimazolam with opioid analgesics, sedatives, and muscle relaxants during simulated Y-site administration
Authors: Kondo Masayoshi , Yoshida Naoki , Yoshida Mariko , Tanaka Chie , Tagami Takashi , Horikawa Kazumi , Sugaya Kazutoshi , Takase Hisamitsu 
Published: September 2022

Abstract

Purpose
There is a lack of information on the compatibility of remimazolam with opioid analgesics, muscle relaxants, and other sedatives. This study aimed to evaluate the physical compatibility of remimazolam with these drug classes.

Methods
Remimazolam was combined with 1 or 2 target drugs (remifentanil, fentanyl, rocuronium, vecuronium, dexmedetomidine, and midazolam). Ten physical compatibility tests were conducted, including four 3-drug compatibility tests. Remimazolam was dissolved in 0.9% sodium chloride injection to a final concentration of 5 mg/mL. Other medications were diluted in 0.9% sodium chloride injection to obtain clinically relevant concentrations. Compatibility tests were conducted with 3 test solutions, wherein remimazolam and the target drugs were compounded at equal volume ratios (1:1 or 1:1:1). Visual appearance was assessed and testing of Tyndall effect, turbidity, and pH was performed immediately after mixing and then again 1 hour and 4 hours after mixing. Appearance and turbidity were evaluated by comparison with the control solution of each target drug diluted with 0.9% sodium chloride injection to the same concentration as the test solution.

Results
All drugs tested were determined to be compatible with remimazolam. The drug combination with the highest change of turbidity was remimazolam and vecuronium (a mean increase of 0.16 NTU relative to the remimazolam control solution), 4 hours after mixing. The combination with the highest pH was remimazolam, fentanyl, and vecuronium (mean [SD], 3.76 [0.01]), 4 hours after mixing. The combination of remimazolam and fentanyl showed a larger change in pH at 4 hours after mixing (a mean increase of 2.6%) than immediately after mixing.

Conclusion
Remifentanil, fentanyl, rocuronium, vecuronium, dexmedetomidine, and midazolam are physically compatible with remimazolam during simulated Y-site administration.
Impact of DaxibotulinumtoxinA for Injection on Brow Position and Frontalis Muscle Activity Following Treatment of Glabellar Lines
Authors: Solish Nowell , Kane Michael A C , Biesman Brian S , Brown Jessica , Gallagher Conor J 
Published: September 2022

Abstract

Background
Botulinum toxin type A (BoNTA) injections for the treatment of facial lines may lead to pleasant or undesirable changes in eyebrow height and position.

Objectives
The aim of this study was to evaluate the impact of glabellar injection of DaxibotulinumtoxinA for Injection (DAXI), a novel BoNTA formulation, on eyebrow position and frontalis activity.

Methods
This study involved the post hoc analysis of adult patients from the Phase 2a forehead lines (FHL, N = 60) and open-label safety (OLS, N = 175) studies who received a single dose of DAXI 40 U to the glabella and for whom facial photographs were taken at rest and at maximum eyebrow elevation. Median vertical and horizontal displacement of the brows and median forehead strain (an objective quantitative assessment of frontalis activity) from baseline to 2 weeks after glabellar DAXI injection were measured.

Results
Two weeks after glabellar DAXI injection, vertical eyebrow movement (at rest) of the lateral brow was observed. In both studies, vertical movement was greatest in the lateral (0.6-0.9 mm) and mid (0.5-0.7 mm) brow regions; movement in the medial brow was negligible (0-0.23 mm). In both studies, a graded reduction in forehead strain was observed 2 weeks post glabellar DAXI injection, with the greatest reduction being in the lower segment (FHL, –73%; OLS, –82%). Treatment with DAXI showed improvements in FHL wrinkle severity.

Conclusions
Glabellar injection of DAXI showed a positive reduction in dynamic frontalis activity that maintained or had a positive effect on eyebrow position. Vertical movement of the brow was suggestive of an improved eyebrow shape with a mild lateral arch.

Level of Evidence: 4
MODIG: integrating multi-omics and multi-dimensional gene network for cancer driver gene identification based on graph attention network model
Authors: Zhao Wenyi , Gu Xun , Chen Shuqing , Wu Jian , Zhou Zhan 
Published: September 2022

Abstract

Motivation
Identifying genes that play a causal role in cancer evolution remains one of the biggest challenges in cancer biology. With the accumulation of high-throughput multi-omics data over decades, it becomes a great challenge to effectively integrate these data into the identification of cancer driver genes.

Results
Here, we propose MODIG, a graph attention network (GAT)-based framework to identify cancer driver genes by combining multi-omics pan-cancer data (mutations, copy number variants, gene expression and methylation levels) with multi-dimensional gene networks. First, we established diverse types of gene relationship maps based on protein–protein interactions, gene sequence similarity, KEGG pathway co-occurrence, gene co-expression patterns and gene ontology. Then, we constructed a multi-dimensional gene network consisting of approximately 20 000 genes as nodes and five types of gene associations as multiplex edges. We applied a GAT to model within-dimension interactions to generate a gene representation for each dimension based on this graph. Moreover, we introduced a joint learning module to fuse multiple dimension-specific representations to generate general gene representations. Finally, we used the obtained gene representation to perform a semi-supervised driver gene identification task. The experiment results show that MODIG outperforms the baseline models in terms of area under precision-recall curves and area under the receiver operating characteristic curves.

Availability and implementation
The MODIG program is available at https://github.com/zjupgx/modig. The code and data underlying this article are also available on Zenodo, at https://doi.org/10.5281/zenodo.7057241.

Supplementary information
Supplementary data are available at Bioinformatics online.
Oligodendrocyte progenitor cell recruitment and remyelination in multiple sclerosis: the more, the merrier?
Authors: Tepavčević Vanja , Lubetzki Catherine 
Published: September 2022

Abstract
Promoting remyelination to prevent/reduce neurodegeneration in patients with multiple sclerosis (MS) is a major therapeutic goal. The longstanding view that the block of oligodendrocyte progenitor cell (OPC) differentiation in MS lesions is the leading cause of remyelination failure has inspired the scientific community to focus primarily on OPC differentiation-promoting compounds as pro-remyelinating agents. Yet, these strategies have been challenged by findings that active MS lesions contain surviving oligodendrocytes that may contribute to remyelination, while many chronic lesions contain low numbers of oligodendroglial cells. In addition, clinical trials using differentiation-stimulating drugs have shown limited efficacy. Thus, a strategic shift in the design of potential remyelination-promoting therapies may be required to achieve significant clinical benefits, which calls for a careful reconsideration of the mechanisms underlying remyelination failure in MS. Here, we argue that both the rate and the efficacy of OPC recruitment are fundamental determinants of remyelination, and that stimulating this process in MS may be crucial to achieve myelin regeneration.
We first review different types of MS lesions in early and chronic MS, with a particular focus on OPCs and surviving oligodendrocytes. Based on the neuropathological findings and results obtained using models of demyelination, we make the case that OPC differentiation block in chronic MS is likely the consequence of defective OPC recruitment during earlier phases of the disease, because (i) if the recruitment is too slow, OPCs reach the axons after what we define as ‘remyelination-permissive window’, and thus remain undifferentiated; and (ii) if the recruitment is inefficient, OPC density in the lesions remains below the threshold required for differentiation.
Importantly, we highlight that OPC proliferation in MS lesions is scarce, which strongly suggests that repeated episodes of demyelination/remyelination (OPC differentiation) will deplete the lesional OPC pool unless perilesional OPCs are recruited. We also point out that surviving mature oligodendrocytes in a subtype of early MS lesions may actually prevent the recruitment of OPCs. Because it has been suggested that OPC-mediated remyelination may be more efficient than that by surviving oligodendrocytes, we suggest that stimulating OPC recruitment during active disease should benefit remyelination in multiple types of lesions, including those with spared oligodendrocytes. Finally, we review molecular determinants of OPC recruitment and suggest a potential therapeutically-relevant strategy to increase this process in patients with MS.