bluuebunny/crossref_metadata_2025_split huggingface dataset:
A shallow salt pond analog for aqueous alteration on ancient Mars: Spectroscopy, mineralogy, and geochemistry of sediments from Antarctica’s Dry Valleys
Authors: Burton Zachary F.M. , Bishop Janice L. , Englert Peter A.J. , Szynkiewicz Anna , Koeberl Christian , Dera Przemyslaw , McKenzie Warren , Gibson Everett K. 
Published: July 2022

AbstractUnderstanding past and present aqueous activity on Mars is critical to constraining martian aqueous geochemistry and habitability, and to searching for life on Mars. Assemblages of minerals observed at or near the martian surface include phyllosilicates, sulfates, iron oxides/hydroxides, and chlorides, all of which are indicative of a complex history of aqueous activity and alteration in the martian past. Furthermore, features observed on parts of the martian surface suggest present-day activity of subsurface brines and at least transient liquid water. Terrestrial analogs for younger and colder (Hesperian–Amazonian) martian geologic and climatic conditions are available in the McMurdo Dry Valleys (MDV) of Antarctica and provide opportunities for improved understanding of more recent aqueous activity on Mars. Here, we study the VXE-6 intermittent brine pond site from Wright Valley in the MDV region and use coordinated spectroscopy, X-ray diffraction, and elemental analyses to characterize the mineralogy and chemistry of surface sediments that have evolved in response to aqueous activity at this site. We find that brine pond activity results in mineral assemblages akin to aqueous alteration products associated with younger sites on Mars. In particular, surficial chlorides, a transition layer of poorly crystalline aluminosilicates and iron oxides/hydroxides, and a deeper gypsum-rich interval within the upper 10 cm of sediment are closely related at this Antarctic brine pond site. Activity of the Antarctic brine pond and associated mineral formation presents a process analog for chemical alteration on the martian surface during episodes of transient liquid water activity during the late Hesperian and/or more recently. Our results provide a relevant example of how aqueous activity in a cold and dry Mars-like climate may explain the co-occurrence of chlorides, clays, iron oxides/hydroxides, and sulfates observed on Mars.
High-temperature phase relations of hydrous aluminosilicates at 22 GPa in the AlOOH-AlSiO3OH system
Authors: Takaichi Goru , Nishi Masayuki , Zhou Youmo , Machida Shinichi , Kitahara Ginga , Yoshiasa Akira , Irifune Tetsuo 
Published: July 2022

Abstract
The stabilities of the minerals that can hold water are important for understanding water behavior in the Earth’s deep interior. Recent experimental studies have shown that the incorporation of aluminum enhances the thermal stabilities of hydrous minerals significantly. In this study, the phase relations of hydrous aluminosilicates in the AlOOH-AlSiO3OH system were investigated at 22 GPa and 1400–2275 K using a multi-anvil apparatus. Based on the X-ray diffraction measurements and composition analysis of the recovered samples, we found that the AlSiO4H phase Egg forms a solid solution with δ-AlOOH above 1500 K. Additionally, at temperatures above 1800 K, two unknown hydrous aluminosilicates with compositions Al2.03Si0.97O6H2.03 and Al2.11Si0.88O6H2.11 appeared, depend ing on the bulk composition of the starting materials. Both phases can host large amounts of water, at least up to 2275 K, exceeding the typical mantle geotherm. The extreme thermal stability of hydrous aluminosilicates suggests that deep-subducted crustal rocks could be a possible reservoir of water in the mantle transition zone and the uppermost lower mantle.
Thermal expansion of minerals in the tourmaline supergroup
Authors: Hovis Guy L. , Tribaudino Mario , Altomare Caitlin , Bosi Ferdinando 
Published: July 2022

Abstract
The thermal behavior of 15 natural tourmaline samples has been measured by X-ray powder diffraction from room temperature to ~930 °C. Axial thermal expansion is generally greater along the c crystallographic axis (αc 0.90–1.05 × 10–5/K) than along the a crystallographic axis and the symmetrically equivalent b axis (αa 0.47–0.60 × 10–5/K). Ferro-bearing samples show lower expansion along a than in other tourmalines. In povondraite the thermal expansion along the c axis is higher than in other tourmalines, whereas along a it is lower [αa = 0.31(2) and αc = 1.49(3) × 10–5/K]. Volume expansion in the tourmaline-supergroup minerals is relatively low compared with other silicates such as pyroxenes and amphiboles. Volume also exhibits a relatively narrow range of thermal expansion coefficients (1.90–2.05 × 10–5/K) among the supergroup members. An interpretation for the small changes in thermal expansion in a compositionally heterogeneous group like tourmaline is that all members, except povondraite, share a framework of dominantly ZAlO6 polyhedra that limit thermal expansion. Povondraite, with a framework dominated by ZFe3+O6 polyhedra, displays thermal expansion that is different from other members of the group.
Unit-cell dimensions of tourmalines having significant Fe2+ deviate from linearity above 400 °C on plots against temperature (T); along with the resulting substantial reduction in unit-cell volume, these effects are likely the result of deprotonation/oxidation processes. Lithium-rich and Fe2+-free tourmalines deviate similarly at T &gt; 600 °C. In Li- and Fe2+-free tourmalines, no such deviation is observed up to the highest temperatures of our experiments. It is not clear whether this is due to cation order-disorder over Y and Z sites that occurs during the highest temperature measurements, a phenomenon that is apparently inhibited (at least in the short term) in Li-free/Mg-rich samples. If so, this must occur at a relatively rapid rate, as no difference in unit-cell values was detected at 800 °C after heating in both one- and 12-h experiments on Na-rich rossmanite.
Measurement of natural frequency and mechanical damping of thin brass diaphragm by pulsed laser generated vibrations
Authors: Azam Muhammad Sohail , Malik Azhar Hussain , Irshad Afshan , Iqbal Mazhar , Ahmad Izhar 
Published: July 2022

Damped harmonic oscillator model based fitting of nanosecond pulsed laser induced amplitude variations of clamped vibrating circular plate is used to estimate the mechanical damping and natural frequency of the sample in current work. Laser Pulses of 50 mJ energy, 20 ns duration, and focused at a spot of 4 mm diameter at the center of the circular thin brass sheet of 100 µm thickness is used to generate vibrations in the target. Quadrature Michelson interferometer (QMI) with CW laser focused on the opposite side of the target surface is used to measure the amplitude of vibrations. Variations of fringe frequencies are identified in the frequency domain. Finite element based numerical modal analyses are also performed in ANSYS Workbench for the verification of experimental results for the same geometry and materials. Experimental frequencies of vibrations are found to match nearly 2 percent of FEM modes. Moreover, Elastic parameters are also found using the first two mode frequencies and a reasonable agreement is observed while comparing with the elastic parameter data of brass. Current work in itself is a unique attempt of getting mechanical parameters for the determination of elastic parameters in a single laser pulse impulse excited measurement for thin clamped targets.
Reforming the Institutional Space for The Development of Municipalities
Authors: Odintsova A. Vl. 
Published: July 2022

Local self-government is the most important component in the system of federative relations. The general indicators of the country’s socio-economic development largely depend on the chosen model of local self-government, the mechanisms of relations between municipalities, both with regional and federal public authorities. The recent changes in the Russian Federation at the level of constitutional and legal regulation have changed the institutional field of municipal development. These changes were followed by the development of two important bills: the Draft Federal Law «On Urban Agglomerations» prepared by the Ministry of Economic Development, and the Draft Federal Law «On the General Principles of Organizing Local Self-Government in a Unified System of Public Power», the analysis of which is the focus of the article. Based on the study of world experience, it is concluded that the transformations of the institutional space of local self-government and municipal development taking place in Russia, in general, correspond to global trends in spatial development. Particular attention is paid to urban agglomerations as, on the one hand, a modern form of spatial organization; and, on the other hand, a form of inter-municipal cooperation.
Epilepsy and Autism Spectrum Disorder (ASD): The Underlying Mechanisms and Therapy Targets Related to Adenosine
Authors: Li Tianfu , Guo Mengyi , Xie Pandeng , Liu Siqi , Luan Guoming 
Published: July 2022

Abstract:Epilepsy and autism spectrum disorder (ASD) are highly mutually comorbid, suggesting potential overlaps in genetic etiology, pathophysiology, and neurodevelopmental abnormalities. Adenosine, an endogenous anticonvulsant and neuroprotective neuromodulator of the brain, has been proved to affect the process of epilepsy and ASD. On the one hand, adenosine plays a crucial role in preventing the progression and development of epilepsy through adenosine receptor-dependent and -independent ways. On the other hand, adenosine signaling can not only regulate core symptoms but also improve comorbid disorders in ASD. Given the important role of adenosine in epilepsy and ASD together, therapeutic strategies related to adenosine, including the ketogenic diet, neuro-modulation therapy, and adenosine augmentation therapy, have been suggested for the arrangement of epilepsy and ASD. There are several proposals in this review. Firstly, based on the comorbid symptoms and mechanisms of epilepsy and ASD, to further discuss the relationship between both diseases. Secondly, to explore the role of adenosine involved in epilepsy and ASD. Lastly, to emphasize the potential therapeutic value and clinical approaches of adenosine-related therapies in treating epilepsy and ASD.
Symptoms of Protracted Alcohol Withdrawal in Patients with Alcohol Use
Disorder: A Comprehensive Systematic Review
Authors: Gallus Silvano , Lugo Alessandra , Borroni Elisa , Vignoli Teo , Lungaro Lisa , Caio Giacomo , De Giorgio Roberto , Zoli Giorgio , Caputo Fabio 
Published: July 2022

Background:
Alcohol withdrawal syndrome (AWS) is characterized by different phases
(acute, early and protracted). Protracted alcohol withdrawal (PAW) presents some symptoms, which
may persist for several weeks, months or even years after drinking cessation.

Methods:
We conducted a systematic review of the literature in major scientific databases on selected
AWS symptoms (craving, sleep disorders, and anhedonia) in patients with alcohol use disorder.

Results:
Of the 102 eligible publications (70 RCTs and 32 cohort studies), 88 provided data on craving,
21 on sleep disorders, and 1 on anhedonia. Overall, 37 studies assessed craving using the Obsessive
Compulsive Drinking Scale (OCDS). Pooled OCDS decreased from 24.2 at baseline to 18.8 at 1
week, 10.3 at 1 month and 9.7 at 3 months. The corresponding estimates for treated individuals were
23.9, 18.8, 8.7, and 8.8, and for non-treated subjects, they were 25.3, 13.9, 13.2, and 11.4, respectively.
In 4 studies assessing sleep disorders using the Epworth Sleeping Scale (ESS), the scale remained stable
in time, i.e., 7.3 at baseline, 7.3 at 1 week, 7.2 at 1 month, and 7.1 at 3 months.

Conclusions:
This study confirms the presence of PAW after the resolution of the acute phase of
AWS. The pharmacological approach to managing PAW may ensure a more rapid reduction of
symptoms in three weeks. We highlight the importance of studying PAW and the ability of pharmacological
treatment to reduce its symptoms.
This review protocol is registered in Prospero (registration number: CRD42020211265).

Summary:
This systematic review summarizes literature on major symptoms of protracted alcohol
withdrawal in patients with alcohol use disorder. The pharmacological approach to manage protracted
alcohol withdrawal ensures a more rapid reduction of symptoms (craving in particular), achieving
in three weeks similar results obtained only after almost 6 months without treatment.
Advanced Microfluidic Vascularized Tissues as Platform for the Study of
Human Diseases and Drug Development
Authors: Noorani Behnam , Cucullo Luca , Ahn Yeseul , Kadry Hossam , Bhalerao Aditya , Raut Snehal , Nozohouri Ehsan , Chowdhury Ekram Ahmed 
Published: July 2022

Abstract:
The vascular system plays a critical role in human physiology and diseases. It is a complex subject to study using in vitro models due to its dynamic and three-dimensional microenvironment. Microfluidic technology has recently become a popular technology in various biological fields for its advantages in mimicking complex microenvironments to an extent not achievable by more conventional platforms. Microfluidic technologies can reproduce different vascular system-related structures and functions that can be utilized for drug development and human diseases studies. Herein we first review the relevant structural and functional vascular biology systems of various organ systems and then the fabrication methods to reproduce these vascular districts. We provide a thorough review of the latest achievement in vascular organ-on-chip modeling specific to lung, heart, and the brain microvasculature for drug screening and the study of human disorders.
Vasorelaxant and Antihypertensive Effects of (3β)-ursen-12-en-3,28-diol by NO/cGMP System
Authors: Guzmán-Ávila Ricardo , Estrada-Soto Samuel , Arias-Durán Luis , Millán-Pacheco César , Escalante-García Jaime , Rios Maria Yolanda , Flores-Morales Virginia , Villalobos-Molina Rafael , Pérez-Barrón Gabriela 
Published: July 2022

Objective:The aim of this study was to determine the vasorelaxant effect of semisynthetic derivatives of ursolic acid, establish the mode of action, and determine the antihypertensive effect of the most active compound.Methods:Isolated aorta rat rings (ex vivo assay), with and without endothelium, were used to determine the vasorelaxant effect of seven semisynthetic derivatives of ursolic acid (UA-01 to UA-07). Then, the effect of the most active compound was studied in ex vivo assay using L-NAME, ODQ and indomethacin to determine its mode action. Finally, the in vivo cardiovascular effect and molecular docking of the most active compound were determined.Results:UA-07 was the most potent compound of the derivatives, since UA-07 induced significant relaxant effect in concentration- and endothelium-dependent manners (Emax = 79.09% and EC50 = 110 μM) on aortic rat rings pre-contracted with noradrenaline (NA, 0.1 μM). Also, endothelium-derived nitric oxide seems to be involved in the mechanism of action of UA-07, because pre-incubation with L-NAME (a NOS inhibitor) and ODQ (a soluble guanylate cyclase inhibitor) significantly reduced its vasorelaxant effect. Further, UA-07 showed a similar binding affinity as ursolic acid on eNOS C1 binding pocket in in silico studies. Finally, treatment with UA-07 (50 mg/Kg) on spontaneously hypertensive rats (SHR) significantly decreased diastolic blood pressure for seven hours.Conclusion:These results demonstrate the significant antihypertensive effect of UA-07, possibly through the NO/cGMP system.
A Case of Cerebral Toxoplasmosis and Cryptococcosis Preferred Therapy
Associated Adverse Drug Reactions in a Patient Newly Co-diagnosed with
Acquired Immune Deficiency Syndrome
Authors: Suryawanshi Vaibhav Rajendra , Purandare Bharat , Rege Sujata , Panda Bijoy Kumar 
Published: July 2022

Purpose:
The simultaneous occurrence of cerebral toxoplasmosis and cryptococcosis is
rare. The infections continue to be treated with sulfadiazine and amphotericin-B-based regimens
(preferred therapy), respectively. Both these drugs are linked to some serious adverse drug reactions
(ADRs). We report such a unique instance of both; the CNS co-infections and adverse drug
reactions to the preferred therapy.

Case Presentation:
A 44-year-old Asian-Indian female was diagnosed with cerebral toxoplasmosis,
impending cryptococcal meningoencephalitis, and acquired immune deficiency syndrome
(AIDS). The preferred therapy of opportunistic CNS co-infections commenced. Within a week, she
had an occurrence of fall in hemoglobin concentrations (11.3 g/dL to 5.6 g/dL; grade IV), reticulocytosis
(1% to 3.2%), and indirect hyperbilirubinemia (0.5 mg/dL to 2.8 mg/dL; grade IV) after
sulfadiazine administration. The drug was discontinued and the patient was treated with hematocrit
transfusions. After amphotericin-B deoxycholate (AmBd) administration, the patient developed
hypokalemia (serum potassium; 4.5 mmol/L to 2.7 mmol/L) and increased serum creatinine (1.0 to
2.2 mg/dL; stage-I) levels. Hence, AmBd was discontinued and potassium correction was given.
The patient got diagnosed with sulfadiazine induced hemolytic anemia and AmBd induced acute
renal failure. He was switched to alternative therapy regimens for the treatment of cerebral toxoplasmosis
and cryptococcosis. Radiological investigations were followed up to confirm the clinical
outcomes of alternative therapy. Complete recovery from the ADRs and opportunistic infections
was observed.

Conclusion:
The preferred therapy regimens for toxoplasmosis and cryptococcosis are accompanied
by potential adverse drug reactions, thus continuous monitoring is vital, especially in
the initial phases of therapy. Discontinuation of the treatment should be the preliminary intervention
in the management. Having said that, alternative therapy regimens had an optimal clinical response
in the present case.
Potential of Mesenchymal Stem Cell Sheets on Periodontal Regeneration:
A Systematic Review of Pre-Clinical Studies
Authors: Mendoza Aldrin Huamán , Balzarini Danilo , Alves Tomaz , Holzhausen Marinella , Rovai Emanuel S. 
Published: July 2022

Background::
Cell sheet technique using mesenchymal stem cells is a high-level strategy in
periodontal regenerative medicine. Although recent studies have shown the role of MSCSs in increased
dental supporting tissues and bone, there is no systematic review focused specifically on assessing periodontal
regeneration in orthotopic animal models.

Objective::
To evaluate the potential of mesenchymal stem cell sheets (MSCSs) on periodontal regeneration,
compared to control, in experimental animal models.

Methods:
Pre-clinical studies in periodontal defects of animal models were considered eligible. The electronic
search included the MEDLINE, Web of Science, EMBASE and LILACS databases. The review
was conducted according to the Preferred Reporting Item for Systematic Reviews and Meta-Analyses
statement guidelines.

Results::
A total of 17 of the 3989 studies obtained from the electronic database search were included.
MSCSs included dental follicle (DF) MSCSs, periodontal ligament (PL) MSCSs, dental pulp (DP)
MSCSs, bone marrow (BM) MSCSs, alveolar periosteal (AP) MSCSs and gingival (G) MSCSs. Regarding
cell sheet inducing protocol, most of the studies used ascorbic acid (52.94%). Others used culture
dishes grafted with a temperature-responsive polymer (47.06%). Adverse effects were not identified in
the majority of studies. Meta-analysis was not considered because of methodological heterogeneities.
PDL-MSCSs were superior for periodontal regeneration enhancement compared to the control, but in an
induced inflammatory microenvironment, DF-MSCSs were better. Moreover, DF-MSCSs, DP-MSCSs,
and BM-MSCSs showed improved results compared to the control.

Conclusion:
MSCSs can improve periodontal regeneration in animal periodontal defect models.
Blind-spot monitoring system using Lidar
Authors: Pawar Kuldeep S. , Teli Shivanand N. , Badgujar Kushal D. , Shetye Prasad , Shetty Saukshit , Satam Vedant , Sahani Atul 
Published: July 2022

Background:
Most of the mishaps withs vehicles takes place because driver is unable to see objects around a vehicle in the blind spot zone. Any vehicle travelling in the blind spot is under serious threat as its presence is completely unknown to the driver.

Objective:
This research paper proposes a blind-spot
monitoring and alert system that is devised to provide an early
warning with regard to the proximity of surrounding vehicles
to the driver.

Methods:
First, the significance of blind-spot monitoring is
described. Then, the different blind-spot detection
technologies compiled during research are presented. Electronics system along with software in the form of mobile

Conclusion:
Our contributions in this paper are (1) A detailed
study for blind spot detection using Lidar. (2) Design and
development of a retrofittable wireless blind-spot detection
system with high accuracy. Additionally, alarm system that
alerts the driver avoiding mishap has been successfully tested.
A German Smartphone-Based Self-management Tool for Psoriasis: Community-Driven Development and Evaluation of Quality-of-Life Effects
Authors: Brandl Lea C , Liebram Claudia , Schramm Wendelin , Pobiruchin Monika 
Published: July 2022

Background
Psoriasis is a chronic disease characterized by inflammation, increased scaling, itching, and other symptoms. Psoriasis is not contagious, but patients have often felt shunned. Therefore, in addition to psoriasis symptoms, stress, anxiety, and depression can also affect quality of life (QoL). Surveys show that only a quarter of patients are satisfied with the success of their therapy. However, in addition to medical therapy, self-management can also make it easier to deal with chronic diseases like psoriasis.

Objective
The aim of this project was to develop a smartphone-based self-management tool (SMT) specifically for patients with psoriasis using a community-driven process. The impact of the SMT on QoL as well as its acceptance and usability were evaluated.

Methods
In collaboration with an internet-based self-help community, 2 user surveys were conducted to determine the requirements for a smartphone-based SMT. The surveys consisted of semistructured questionnaires asking for desired features in an SMT for psoriasis. A pilot study was conducted to evaluate QoL, acceptance, and usability. Community users were recruited to use the app for 21 days and complete the Dermatology Life Quality Index (DLQI) questionnaire at the beginning (T0) and end (T1). Afterward, participants were asked to complete another questionnaire on usability and ease of use.

Results
SMT requirements were collected from 97 members of an internet-based community. The SMT was built as a progressive web app that communicates with a server back end and an Angular web app for content management. The app was used by 15 participants who also provided qualitative feedback, and 10 participants answered all questionnaires. The average DLQI score was 7.1 (SD 6.2) at T0 and 6.9 (SD 6.6) at T1. The minimal required sample size of 27 was not reached.

Conclusions
The high degree of community participation in the development process and the responses during the requirement engineering process indicated that there is a general need for an independently developed SMT for patients with psoriasis. However, the feedback received after app use shows that the SMT does not meet the needs of the community. It can be concluded that a more customizable app is needed. The focus and needs of the users were very heterogeneous. Similar developments and research could benefit from the findings of this project.