bluuebunny/crossref_metadata_2025_split huggingface dataset:
Searching for light new physics at the LHC via lepton-number violation
Authors: Bensalem Wafia , London David , Stolarski Daniel , Tonero Alberto 
Published: April 2022

Abstract
We study the collider phenomenology of a simplified model containing a right-handed W in which the WR couples predominantly to the third generation in the quark sector. The model also includes a light Majorana neutrino, with M1 ∼ $$ \mathcal{O}(100) $$
O

100

GeV, giving rise to lepton-number-violating signatures that are visible at the LHC. Taking into account all the searches from the LHC and Tevatron, we find that this WR can still be as light as MR ∼ 300 GeV. We show that this type of new physics, and others like it, can be detected at the LHC using final states with three same-sign same-flavour leptons.
Euclidean time approach to entanglement entropy on lattices and fuzzy spaces
Authors: Allouche A. , Dou D. 
Published: April 2022

Abstract
In a recent letter, Phys. Lett. B792 (2019) 60, we developed a novel Euclidean time approach to compute Rényi entanglement entropy on lattices and fuzzy spaces based on Green’s function. The present work is devoted in part to the explicit proof of the Green’s matrix function formula which was quoted and used in the previous letter, and on the other part to some applications of this formalism. We focus on scalar theory on 1+1 lattice. We also use the developed approach to systematically go beyond the Gaussian case by considering interacting models, in particular our results confirm earlier expectations concerning the correction to the entanglement at first order. We finally outline how this approach can be used to compute the entanglement entropy on fuzzy spaces for free and interacting scalar theories.
Saponin-based adjuvant-induced dendritic cell cross-presentation is dependent on PERK activation
Authors: Huis in ’t Veld Lisa G. M. , Ho Nataschja I. , Wassink Melisssa , den Brok Martijn H. , Adema Gosse J. 
Published: April 2022

AbstractSaponin-based adjuvants (SBAs) are promising new adjuvants that stand out as they not only enforce CD4 + T cell-mediated immunity and antibody responses, but also induce an unprecedented level of antigen cross-presentation by dendritic cells (DC) and subsequent CD8 + T cell activation. We discovered that SBA’s ability to boost cross-presentation depends on the induction of lipid bodies (LBs). Moreover, the MHCIIloCD11bhiDC subset was identified to be most responsive to SBA-induced cross-presentation. The aim is to further unravel the mechanisms behind the induction of DC cross-presentation by SBAs. Here we show that SBAs specifically induce the PKR-like Endoplasmic Reticulum kinase (PERK) pathway and that SBA-induced DC cross-presentation is dependent on activation of the PERK pathway. PERK activation and LB formation are both crucial for SBA-induced cross-presentation and PERK inhibition has little or no effect on SBA-induced LB formation. SBA’s responsiveness, LB formation and PERK activation are specific for the MHCIIloCD11bhiDCs. These findings contribute to understanding the pathways involved in SBA-induced cross-presentation and immune activation which will ultimately lead to the development of vaccines with improved efficiency and safety.
The effect of the Rht1 haplotype on Fusarium head blight resistance in relation to type and level of background resistance and in combination with Fhb1 and Qfhs.ifa-5A
Authors: Buerstmayr Maria , Buerstmayr Hermann 
Published: April 2022

Abstract
Key message
The effect of the Rht1-genes on FHB resistance depends on anther extrusion and level of background resistance. Qfhs.ifa-5A increases resistance and anther extrusion as efficiently as semi-dwarfing alleles decrease it.

Abstract
The semi-dwarfing reduced height alleles Rht-D1b and Rht-B1b have been deployed in modern wheat cultivars throughout the world, but they increase susceptibility to Fusarium head blight (FHB). Here, we investigated the impact of the Rht1 genes on anther retention (AR) in relation to FHB resistance using four different sets of near-isogenic lines (NILs) with contrasting levels and types of background FHB resistance. NILs were evaluated for FHB severity, plant height and AR in three greenhouse and three field trials using artificial spray inoculation. Rht-B1b and Rht-D1b alleles increased AR and FHB susceptibility in all genetic backgrounds. The magnitude of the effects differed between NIL groups. Increased FHB susceptibility largely followed increased AR. Differences in FHB susceptibility between tall and dwarf haplotypes were largest in the NIL group with the highest changes in AR. In the most resistant NIL group, dwarfed lines had only slightly higher AR than tall lines and maintained good resistance, while both tall and dwarf lines had high levels of retained anthers in the most susceptible NIL group. We further investigated the effect of the major Fusarium resistance QTL Fhb1 and Qfhs.ifa-5A in combination with the Rht1 genes. Qfhs.ifa-5A enhanced anther extrusion in tall as well as semi-dwarf haplotypes, whereas Fhb1 did not affect AR. Qfhs.ifa-5A supported FHB resistance more efficiently than Fhb1 in lines that were more responsive to AR, while both Fhb1 and Qfhs.ifa-5A were equally efficient in NILs that had high background resistance and low response to AR.
Endoscopically assisted reconstruction of chronic Achilles tendon ruptures and re-ruptures using a semitendinosus autograft is a viable alternative to pre-existing techniques
Authors: Nilsson Niklas , Gunnarsson Baldvin , Carmont Michael R. , Brorsson Annelie , Karlsson Jón , Nilsson Helander Katarina 
Published: April 2022

Abstract
Purpose
Achilles tendon ruptures are termed chronic after a delay in treatment for more than 4 weeks. The literature advocates surgical treatment with reconstruction to regain ankle push-off strength. The preferred technique is, however, still unknown and is often individualized. This study aims to present the technique and clinical outcome of an endoscopically assisted free semitendinosus reconstruction of chronic Achilles tendon rupture and Achilles tendon re-ruptures with delayed representation. It is hypothesized that the presented technique is a viable and safe alternative for distal Achilles tendon ruptures and ruptures with large tendon gaps.

Method
Twenty-two patients (13 males and 9 females) with a median (range) age of 64 (34–73) treated surgically with endoscopically assisted Achilles tendon reconstruction using a semitendinosus autograft were included. The patients were evaluated at 12 months post-operatively for Achilles tendon Total Rupture Score (ATRS), calf circumference, Achilles Tendon Resting Angle (ATRA), heel-rise height and repetitions together with tendon length determined by ultrasonography, concentric heel-rise power and heel-rise work.

Results
The patients reported a median (range) ATRS of 76 (45–99) out of 100. The median (range) ATRA on the injured side was 60° (49°-75°) compared with 49.5° (40–61°), p < 0.001, on the non-injured side. Eighteen out of 22 patients were able to perform a single-leg heel-rise on the non-injured side. Sixteen patients out of those 18 (89%) were also able to perform a single heel-rise on the injured side. They did, however, perform significantly lower number of repetitions compared with the non-injured side with a median (range) heel-rise repetitions of 11 (2–22) compared with 26 (2–27), (p < 0.001), and a median (range) heel-rise height of 5.5 cm (1.0–11.0 cm) compared with 9.0 cm (5.0–11.5 cm), (p < 0.001). The median calf circumference was 1.5 cm smaller on the injured side, 37.5 cm compared with 39 cm, when medians were compared. The median (range) tendon length of the injured side was 24.8 cm (20–28.2 cm) compared with 22 cm (18.4–24.2 cm), (p < 0.001), on the non-injured side.

Conclusion
The study shows that endoscopically assisted reconstruction using a semitendinosus graft to treat chronic Achilles tendon ruptures and re-ruptures with delayed representation produces a satisfactory outcome. The technique can restore heel-rise height in patients with more distal ruptures or large tendon defects and is therefore a viable technique for Achilles tendon reconstruction.

Level of evidence
IV.
Entropy and convergence analysis for two finite volume schemes for a Nernst–Planck–Poisson system with ion volume constraints
Authors: Gaudeul Benoît , Fuhrmann Jürgen 
Published: April 2022

AbstractIn this paper, we consider a drift-diffusion system with cross-coupling through the chemical potentials comprising a model for the motion of finite size ions in liquid electrolytes. The drift term is due to the self-consistent electric field maintained by the ions and described by a Poisson equation. We design two finite volume schemes based on different formulations of the fluxes. We also provide a stability analysis of these schemes and an existence result for the corresponding discrete solutions. A convergence proof is proposed for non-degenerate solutions. Numerical experiments show the behavior of these schemes.
Pulse Wave Velocity Measurements by Magnetic Resonance Imaging in Neonates and Adolescents: Methodological Aspects and Their Clinical Implications
Authors: Lundström Simon , Liefke Jonas , Heiberg Einar , Hedström Erik 
Published: April 2022

AbstractPulse wave velocity (PWV) by cardiovascular magnetic resonance (CMR) lacks standardization. The aim of this study was to investigate methodological aspects of PWV measurements by CMR in neonates and adolescents. A computer phantom was created to validate the temporal resolution required for accurate PWV. Fifteen neonates and 71 adolescents underwent CMR with reference standard 3D angiography and phase-contrast flow acquisitions, and in a subset coronal overview images. Velocity and flow curves, transit time methods (time-to-foot (TTF), maximum upslope, and time-to-peak (TTP)), and baseline correction methods (no correction, automatic and manual) were investigated. In neonates, required timeframes per cardiac cycle for accurate PWV was 42 for the aortic arch and 41 for the thoracic aorta. In adolescents, corresponding values were 39 and 32. Aortic length differences by overview images and 3D angiography in adolescents were − 16–18 mm (aortic arch) and − 25–30 mm (thoracic aorta). Agreement in PWV between automatic and manual baseline correction was − 0.2 ± 0.3 m/s in neonates and 0.0 ± 0.1 m/s in adolescents. Velocity and flow-derived PWV measurements did not differ in either group (all p > 0.08). In neonates, transit time methods did not differ (all p > 0.19) but in adolescents PWV was higher for TTF (3.8 ± 0.5 m/s) and maximum upslope (3.7 ± 0.6 m/s) compared to TTP (2.7 ± 1.0 m/s; p < 0.0001). This study is a step toward standardization of PWV in neonates and adolescents using CMR. It provides required temporal resolution for phase-contrast flow acquisitions for typical heartrates in neonates and adolescents, and supports 3D angiography and time-to-foot with automatic baseline correction for accurate PWV measurements.
The (extended) achondroplasia foramen magnum score has good observer reliability
Authors: Jenko Nathan , Connolly Daniel J. A. , Raghavan Ashok , Fernandes James A. , Ushewokunze Shungu , Elphick Heather E. , Arundel Paul , Alhun Utku , Offiah Amaka C. 
Published: April 2022

Abstract
Background
Achondroplasia is the most common skeletal dysplasia. A significant complication is foramen magnum stenosis. When severe, compression of the spinal cord may result in sleep apnea, sudden respiratory arrest and death. To avoid complications, surgical decompression of the craniocervical junction is offered in at-risk cases. However, practice varies among centres. To standardize magnetic resonance (MR) reporting, the achondroplasia foramen magnum score was recently developed. The reliability of the score has not been assessed.

Objective
To assess the interobserver reliability of the achondroplasia foramen magnum score.

Materials and methods
Base of skull imaging of children with achondroplasia under the care of Sheffield Children’s Hospital was retrospectively and independently reviewed by four observers using the achondroplasia foramen magnum score. Two-way random-effects intraclass coefficient (ICC) was used to assess inter- and intra-observer reliability.

Results
Forty-nine eligible cases and five controls were included. Of these, 10 were scored normal, 17 had a median score of 1 (mild narrowing), 11 had a median score of 2 (effacement of cerebral spinal fluid), 10 had a score of 3 (compression of cord) and 6 had a median score of 4 (cord myelopathic change). Interobserver ICC was 0.72 (95% confidence interval = 0.62–0.81). Intra-observer ICC ranged from 0.60 to 0.86. Reasons for reader disagreement included flow void artefact, subtle T2 cord signal and myelopathic T2 cord change disproportionate to canal narrowing.

Conclusion
The achondroplasia foramen magnum score has good interobserver reliability. Imaging features leading to interobserver disagreement have been identified. Further research is required to prospectively validate the score against clinical outcomes.
Volatile Organic Compounds in the Early Diagnosis of Non‐healing Surgical Wounds: A Systematic Review
Authors: Reeves Nicola , Phillips Samuel , Hughes Aron , Maddocks Sarah , Bates Matthew , Torkington Jared , Robins Lori , Cornish Julie 
Published: April 2022

AbstractBackgroundThe normal healing of surgical wounds can be disrupted by infection and/or dehiscence, leading to development of chronic, non‐healing wounds (NHW). Diagnosis of NHWs is via clinical acumen and analysis of microbiology wound swabs. Volatile organic compounds (VOCs) are emitted generally by human subjects and specifically as products of bacterial metabolism and are detected in the wound area. This systematic review will assess the potential use of VOCs released by surgical wounds as a non‐invasive method for identifying bacterial species and the progression to NHW.MethodA systematic search of studies, via PRISMA guidelines, was conducted. Of 220 papers screened, seven studies were included. Outcome data were extracted on methods for VOC analysis and wound/bacterial VOC profiles.ResultsThe studies have shown that VOC profiles are identified by two methods: gas chromatography–mass spectrometry and electronic nose. There are VOC profiles associated with causative bacterial species, with early indications that they could be anatomically specific or could monitor treatment effects.ConclusionVOC profiling of bacterial species within wounds is possible and could become a point of care test. More research is needed on specific VOC profiles to wound location and whether these profiles may predict progression to NHW.
An Educational Module to Teach Interprofessional Learner Feedback Skills for Trauma Simulation Events
Authors: Dickinson Karen J. , Kimbrough Mary Katherine , Young Amanda , Goddard Clayton , Urban Kelly , Kalkwarf Kyle J. , Bhavaraju Avi , Margolick Joseph 
Published: April 2022

AbstractBackgroundPeer feedback, or feedback given by a learner to another learner, is an important active learning strategy. Hierarchy and stereotypes may affect interprofessional (IP) learner‐to‐learner feedback. The aim was to assess the efficacy of an educational module for IP learners in delivering effective feedback during trauma simulations.MethodsMultiple simulation events designed to improve teamwork and leadership skills during trauma simulations included IP learners (residents and nurses). Participants completed a pre‐course educational module on IP peer feedback. The Trauma Team Competence Assessment‐24 tool structured feedback. Learners completed pre/post‐assessments utilizing IP Collaborative Competencies Attainment Survey (ICCAS).ResultsTwenty‐five learners participated in the trauma simulations (13 general surgery and 5 emergency residents, 3 medical students, 4 nurses). The majority of learners had either not received any previous training in how to effectively deliver peer feedback (40%) or had engaged in self‐directed learning only (24%). Most learners (64%) had delivered peer feedback less than ten times. Learner knowledge and confidence in delivering feedback to fellow IP learners improved after simulations. All learners felt the feedback received was useful to their daily practice (68% agree, 32% strongly agree). All participants agreed that the simulation achieved each of the ICCAS competencies.ConclusionsFormal education on IP peer feedback is rare. This pilot work demonstrates educational modules with a foundation in validated tools can be effective in improving learner knowledge and confidence in the process. Engaging in IP peer feedback may also serve to flatten hierarchies that can challenge effective interprofessional teamwork.
Development and evaluation of machine learning models based on X-ray radiomics for the classification and differentiation of malignant and benign bone tumors
Authors: von Schacky Claudio E. , Wilhelm Nikolas J. , Schäfer Valerie S. , Leonhardt Yannik , Jung Matthias , Jungmann Pia M. , Russe Maximilian F. , Foreman Sarah C. , Gassert Felix G. , Gassert Florian T. , Schwaiger Benedikt J. , Mogler Carolin , Knebel Carolin , von Eisenhart-Rothe Ruediger , Makowski Marcus R. , Woertler Klaus , Burgkart Rainer , Gersing Alexandra S. 
Published: April 2022

Abstract
Objectives
To develop and validate machine learning models to distinguish between benign and malignant bone lesions and compare the performance to radiologists.

Methods
In 880 patients (age 33.1 ± 19.4 years, 395 women) diagnosed with malignant (n = 213, 24.2%) or benign (n = 667, 75.8%) primary bone tumors, preoperative radiographs were obtained, and the diagnosis was established using histopathology. Data was split 70%/15%/15% for training, validation, and internal testing. Additionally, 96 patients from another institution were obtained for external testing. Machine learning models were developed and validated using radiomic features and demographic information. The performance of each model was evaluated on the test sets for accuracy, area under the curve (AUC) from receiver operating characteristics, sensitivity, and specificity. For comparison, the external test set was evaluated by two radiology residents and two radiologists who specialized in musculoskeletal tumor imaging.

Results
The best machine learning model was based on an artificial neural network (ANN) combining both radiomic and demographic information achieving 80% and 75% accuracy at 75% and 90% sensitivity with 0.79 and 0.90 AUC on the internal and external test set, respectively. In comparison, the radiology residents achieved 71% and 65% accuracy at 61% and 35% sensitivity while the radiologists specialized in musculoskeletal tumor imaging achieved an 84% and 83% accuracy at 90% and 81% sensitivity, respectively.

Conclusions
An ANN combining radiomic features and demographic information showed the best performance in distinguishing between benign and malignant bone lesions. The model showed lower accuracy compared to specialized radiologists, while accuracy was higher or similar compared to residents.

Key Points
• The developed machine learning model could differentiate benign from malignant bone tumors using radiography with an AUC of 0.90 on the external test set.
• Machine learning models that used radiomic features or demographic information alone performed worse than those that used both radiomic features and demographic information as input, highlighting the importance of building comprehensive machine learning models.
• An artificial neural network that combined both radiomic and demographic information achieved the best performance and its performance was compared to radiology readers on an external test set.
Fine scale reconstruction (VIC#) by implementing additional constraints and coarse-grid approximation into VIC+
Authors: Jeon Young Jin , Müller Markus , Michaelis Dirk 
Published: April 2022

AbstractThis study proposes a method that complements Vortex-In-Cell plus (VIC+) (Schneiders and Scarano, Exp Fluids 57:139, 2016), a data assimilation technique that reconstructs a dense flow field from sparse particle tracks. Here, the focus is on the treatment of boundary conditions. In the VIC+ method, the choice of boundary conditions significantly affects a large part of the inner domain through their role as Dirichlet boundary conditions of the Poisson equations. By nature, there are particle tracks on one side of the boundaries, and often, due to experimental limitations, the track density is low, just close to the boundaries. This lack of data near the boundaries leads to a poor iterative update of the boundary condition for VIC+. Overall, the VIC+ method tends to be sensitive about the specific choice of the initial conditions, including the inner domain and the boundaries. Without prior flow information, a large padded volume has been proposed to achieve stable and reliable convergence, at the cost of a large number of additional unknowns that need to be optimized. The present method pursues the following concepts to resolve the above issues: use of the smallest possible padding size, reconstruction starting with “all zero” initial conditions, and progressive correction of the boundary conditions by considering the continuity law and the Navier–Stokes equation. These physical laws are incorporated as additional terms in the cost function, which so far only contained the disparity between PTV measurements and the VIC+ reconstruction. Here, the Navier–Stokes equation allows an instantaneous pressure field to be optimized simultaneously with the velocity and acceleration fields. Moreover, the scale parameters in VIC+ are redefined to be directly computed from PTV measurement instead of using the initial condition, and new scaling factors for the additional cost function terms are introduced. A coarse-grid approximation is employed in order to both improve reconstruction stability and save computation time. It provides a subsequent finer-grid with its low-resolution result as an initial condition while the interrogation volume slightly shrinks. A numerical assessment is conducted using synthetic PTV data generated from the direct numerical simulation data of forced isotropic turbulence from the Johns Hopkins Turbulence Database. Improved reconstructions, especially near the volume boundary, are achieved while the virtues of VIC+ are preserved. As an experimental assessment, the existing data from a time-resolved water jet is processed. Two reconstruction domains with different sizes are considered to compare the boundary of the smaller domain with the inside of the larger one. Visible enhancements near the boundary of the smaller domain are observed for this new approach in time-varying flow fields despite the limited input from PTV data.
Graphical abstract