bluuebunny/crossref_metadata_2025_split huggingface dataset:
Probing inside a charged hairy black hole in massive gravity
Authors: Mirjalali Mirmani , Mansoori Seyed Ali Hosseini , Shahkarami Leila , Rafiee Morteza 
Published: September 2022

AbstractIn this paper, we investigate the internal structure of a charged hairy black hole solution in the non-linear massive gravity. We first consider the impact of various configurations of massive gravity on the condensate operator and then probe the black hole interior dynamics. Like a standard holographic superconductor system, just below the critical temperature, the interior evolves through several distinct epochs, including a collapse of the Einstein-Rosen bridge, Josephson oscillations of the scalar field, and finally a Kasner (or Kasner inversion) cosmology. However, for the large massive gravity parameter, we see distinguishing features for the interior dynamics. In this regime, at a given temperature, the Einstein-Rosen bridge collapse and subsequent Josephson oscillations epochs completely disappear from the interior dynamics and the final Kasner cosmology epoch starts exactly after the would-be inner horizon and the system does not experience the Kasner inversion epoch.
Multiplicity of Solutions for an Elliptic Kirchhoff Equation
Authors: Arcoya David , Carmona José , Martínez-Aparicio Pedro J. 
Published: September 2022

AbstractIn this paper we study the existence of positive solution to the Kirchhoff elliptic problem $$\begin{aligned} {\left\{ \begin{array}{ll} \displaystyle -\left( 1+\gamma G'\left( \Vert \nabla u\Vert ^2_{L^2(\Omega )}\right) \right) \Delta u = \lambda f(u) &{} \text{ in } \; \Omega ,\\ u = 0 &{} \text{ on } \; \partial \Omega ,\\ \end{array}\right. } \end{aligned}$$

-

1
+
γ

G
′

‖
∇
u
‖

L
2

(
Ω
)

2

Δ
u
=
λ
f

(
u
)

in

Ω
,

u
=
0

on

∂
Ω
,

where $$\Omega $$
Ω
is an open, bounded subset of $$\mathbb {R}^N$$

R

N

($$N\ge 3$$

N
≥
3

), f is a locally Lipschitz continuous real function, $$f(0)\ge 0$$

f
(
0
)
≥
0

, $$G'\in C(\mathbb {R}^+)$$

G
′

∈
C

(

R

+

)

and $$G'\ge 0$$

G
′

≥
0

. We prove the existence of at least two solutions with $$L^\infty (\Omega )$$

L
∞

(
Ω
)

norm between two consecutive zeroes of f for large $$\lambda $$
λ
.
Signed (Group) Diffie–Hellman Key Exchange with Tight Security
Authors: Pan Jiaxin , Qian Chen , Ringerud Magnus 
Published: September 2022

AbstractWe propose the first tight security proof for the ordinary two-message signed Diffie–Hellman key exchange protocol in the random oracle model. Our proof is based on the strong computational Diffie–Hellman assumption and the multiuser security of a digital signature scheme. With our security proof, the signed DH protocol can be deployed with optimal parameters, independent of the number of users or sessions, without the need to compensate any security loss. We abstract our approach with a new notion called verifiable key exchange. In contrast to a known tight three-message variant of the signed Diffie–Hellman protocol (Gjøsteen and Jager, in: Shacham, Boldyreva (eds) CRYPTO 2018, Part II. LNCS, Springer, Heidelberg, 2018), we do not require any modification to the original protocol, and our tightness result is proven in the “Single-Bit-Guess” model which we know can be tightly composed with symmetric cryptographic primitives to establish a secure channel. Finally, we extend our approach to the group setting and construct the first tightly secure group authenticated key exchange protocol.
No advantage with navigated versus conventional mechanically aligned total knee arthroplasty—10 year results of a randomised controlled trial
Authors: Farhan-Alanie Omer M. , Altell Tareq , O’Donnell Sinead , May Pauline , Doonan James , Rowe Philip , Jones Bryn , Blyth Mark J. G. 
Published: September 2022

Abstract
Purpose
Computer-assisted surgery (CAS) total knee arthroplasty (TKA) remains a controversial area of surgical practice. The aim of this study is to report the ten-year revision rates and patient-reported outcome measures (PROMS) of a single-blinded, prospective, randomised controlled trial comparing electromagnetically (EM) navigated and conventional TKA.

Methods
199 patients were randomised to receive either EM navigated or conventional TKA where the aim of implantation was neutral mechanical alignment in all cases. Ten-year revision rates were collated and compared between the two intervention groups. Longitudinal PROMS data was collected prospectively at various time points up to 10 years post-operatively.

Results
Over the ten-year period, there were 23 deaths (22.8%) in the EM navigation cohort and 30 deaths (30.6%) in the conventional cohort. At 10 years post-operatively, there was no statistically significant difference in all cause revision between the EM navigation and conventional cohort (4.0 vs 6.1%, p = 0.429). When analysing causes of revision that might be influenced by utilising EM navigation, there was no statistically significant difference in revisions (3.0% EM navigated vs 4.1% conventional group, p = 0.591). Patients that received navigated TKAs had improved Oxford Knee Society, American Knee Society Score and range of motion at 3 months following surgery compared to conventional TKA (p = 0.002, p = 0.032, and p = 0.05, respectively). However, from 1 to 10 years post-operatively, both interventions had equivalent outcomes.

Conclusion
There is no difference in revision rates or clinical outcomes comparing EM navigated versus conventional TKA at ten-year follow-up. The expected mortality rate makes it unlikely that a difference in revision rates will reach statistical significance in the future. In the setting of an experienced knee arthroplasty surgeon, it is difficult to justify the additional costs of CAS in TKA surgery.

Level of evidence
I
Predicting future failure times by using quantile regression
Authors: Navarro Jorge , Buono Francesco 
Published: September 2022

AbstractThe purpose of the paper is to study how to predict the future failure times in a sample from the early failures (type II censored data). We consider both the case of independent and dependent lifetimes. In both cases we assume identically distributed random variables. To predict the future failures we use quantile regression techniques that also provide prediction regions for them. Some illustrative examples show how to apply the theoretical results to simulated and real data sets.
The Australian mixed-mode observing program
Authors: McCallum Lucia , Chin Chuan Lim , Krásná Hana , McCallum Jamie , Böhm Johannes , McCarthy Tiege , Gruber Jakob , Schartner Matthias , Quick Jonathan , Rogers Axl 
Published: September 2022

AbstractGlobal geodetic VLBI is upgrading to its next-generation observing system, VGOS. This upgrade has turned out to be a process over multiple years, until VGOS reaches its full capabilities with the envisaged continuous observations. Until then, for the Australian stations, the upgrade means ceasing their legacy S/X observations, leaving a large gap in the global network as well as in the station time series. The Australian mixed-mode observing program is a series of sessions where the VGOS stations in Hobart and Katherine observe legacy S/X VLBI together with other stations in the region. This paper describes the technical details of these observations and their processing strategies and discusses their suitability for geodetic results by comparison with those of standard legacy S/X sessions. The presented mixed-mode sessions allow a continuation of the station time series, a benefit for the stations themselves as well as for future realisations of the terrestrial and celestial reference frames. A novel mode of observing is introduced and tested. The results are promising and it is suggested for acceptance into standard legacy S/X IVS observations, overcoming current gaps in the network due to VGOS upgrades and preventing a worsening of global results otherwise.
Long-term changes in adult size of green turtles at Aldabra Atoll and implications for clutch size, sexual dimorphism and growth rates
Authors: Mortimer Jeanne A. , Appoo Jennifer , Bautil Bruno , Betts Michael , Burt April J. , Chapman Roselle , Currie Jock C. , Doak Naomi , Esteban Nicole , Liljevik Anna , Mahoune Jourdan Terence , Onezia Catherina , Pistorius Pierre , Richards Heather , Samedi Uzice , Sanchez Cheryl L. , Seabrook Wendy , Underwood Alex , van de Crommenacker Janske , von Brandis Rainer , Hays Graeme C. 
Published: September 2022

AbstractAround the world, declines in the mean size of nesting sea turtles have been reported with concerns of a concomitant decrease in the reproductive output of populations. Here, we explore this possibility using long-term observations of green turtles (Chelonia mydas) at Aldabra Atoll, Seychelles. Based on > 4500 individual measurements over 21 years (1996–2016), we found the curved carapace length of nesting females declined by about 0.64 cm per decade, from 111.43 to 110.08 cm. For 391 individuals that were measured more than once with measurement interval of 2.8–19 years apart, the mean growth rate was 0.14 cm year−1. Comparisons between the size of adult females and males were based on 23 and 14 weight measurements, 107 and 33 carapace length measurements and 103 and 33 carapace width measurements, respectively, taken during 1981–1983. Adult females were larger than males, with the sexual dimorphism index, i.e. the ratio of size of the larger sex to the smaller, being 1.09 and 1.10 for carapace length and width, respectively, and 1.25 for weight. Smaller females tended to lay fewer eggs per clutch but the decrease in female mean size was accompanied by increases in numbers of turtles nesting annually, such that the estimated total numbers of eggs per year increased from 1.3 million to 2.0 million between 1996 and 2016. Therefore, a decrease in mean size of nesting females has not compromised egg production for this population.
Identification of polyketide synthase genes required for aspinolide biosynthesis in Trichoderma arundinaceum
Authors: Cardoza Rosa E. , McCormick Susan P. , Izquierdo-Bueno Inmaculada , Martínez-Reyes Natalia , Lindo Laura , Brown Daren W. , Collado Isidro G. , Proctor Robert H. , Gutiérrez Santiago 
Published: September 2022

AbstractThe fungusTrichoderma arundinaceumexhibits biological control activity against crop diseases caused by other fungi. Two mechanisms that likely contribute to this activity are upregulation of plant defenses and production of two types of antifungal secondary metabolites: the sesquiterpenoid harzianum A (HA) and the polyketide-derived aspinolides. The goal of the current study was to identify aspinolide biosynthetic genes as part of an effort to understand how these metabolites contribute to the biological control activity ofT. arundinaceum. Comparative genomics identified two polyketide synthase genes (asp1andasp2) that occur inT. arundinaceumandAspergillus ochraceus, which also produces aspinolides. Gene deletion and biochemical analyses inT. arundinaceumindicated that both genes are required for aspinolide production:asp2for formation of a 10-member lactone ring andasp1for formation of a butenoyl subsituent at position 8 of the lactone ring. Gene expression and comparative genomics analyses indicated thatasp1andasp2are located within a gene cluster that occurs in bothT. arundinaceumandA. ochraceus. A survey of genome sequences representing 35 phylogenetically diverseTrichodermaspecies revealed that intact homologs of the cluster occurred in only two other species, which also produced aspinolides. Anasp2mutant inhibited fungal growth more than the wild type, but anasp1mutant did not, and the greater inhibition by theasp2mutant coincided with increased HA production. These findings indicate thatasp1andasp2are aspinolide biosynthetic genes and that loss of either aspinolide or HA production inT. arundinaceumcan be accompanied by increased production of the other metabolite(s).Key points•Two polyketide synthase genes are required for aspinolide biosynthesis.•Blocking aspinolide production increases production of the terpenoid harzianum A.•Aspinolides and harzianum A act redundantly in antibiosis of T. arundinaceum.
How Effective is the Use of Molecular Testing in Preoperative Decision Making for Management of Indeterminate Thyroid Nodules?
Authors: Steinmetz David , Kim Mary , Choi Jee‐Hye , Yeager Tamanie , Samuel Krupa , Khajoueinejad Nazanin , Buseck Alison , Imtiaz Sayed , Fernandez‐Ranvier Gustavo , Lee Denise , Owen Randall , Taye Aida 
Published: September 2022

AbstractIntroductionWe performed Thyroseq v2 molecular testing on indeterminate thyroid nodules and evaluated whether they underwent a management change from the standard of thyroid lobectomy.MethodsWe conducted a retrospective analysis of all indeterminate thyroid nodules that underwent Thyroseq v2 molecular testing from 2014 to 2019 at a large academic center. Pathology was reviewed by thyroid cytopathologists. Thyroseq results were reported benign (malignancy probability less than 10%) or suspicious (malignancy probability greater than 30%). The primary endpoint was a management change from a diagnostic lobectomy.ResultsA total of 142 nodules were included: 113 (80%) Bethesda III and 29 (20%) Bethesda IV. Seventy‐three nodules underwent surgical management and 69 did not. We noted a change in management in 64% (91/142) of nodules. Patients who underwent a change in management to no surgery had a significantly higher rate of benign Thyroseq result than those without a change (75.8% vs. 49.0%, p = 0.001). On logistic regression analysis, a benign Thyroseq result was a positive independent predictor of a change to no surgery (OR 3.87, 95% CI 1.69–8.89). Nodule size, multiple nodules, compressive symptoms, and history of hypothyroidism were not significant. Of the 91 patients who underwent a management change, 71% (65/91) did not undergo surgery. On follow‐up (average 985 ± 615 days), 12% (8/65) of those nodules were growing or developed suspicious features requiring surgery.ConclusionsMolecular testing helped avoid surgery in almost half our population with indeterminate thyroid nodules, and benign results may help avoid surgery in asymptomatic patients with indeterminate thyroid nodules.
Application of deep learning–based image reconstruction in MR imaging of the shoulder joint to improve image quality and reduce scan time
Authors: Kaniewska Malwina , Deininger-Czermak Eva , Getzmann Jonas M. , Wang Xinzeng , Lohezic Maelene , Guggenberger Roman 
Published: September 2022

Abstract
Objectives
To compare the image quality and diagnostic performance of conventional motion-corrected periodically rotated overlapping parallel line with enhanced reconstruction (PROPELLER) MRI sequences with post-processed PROPELLER MRI sequences using deep learning-based (DL) reconstructions.

Methods
In this prospective study of 30 patients, conventional (19 min 18 s) and accelerated MRI sequences (7 min 16 s) using the PROPELLER technique were acquired. Accelerated sequences were post-processed using DL. The image quality and diagnostic confidence were qualitatively assessed by 2 readers using a 5-point Likert scale. Analysis of the pathological findings of cartilage, rotator cuff tendons and muscles, glenoid labrum and subacromial bursa was performed. Inter-reader agreement was calculated using Cohen’s kappa statistic. Quantitative evaluation of image quality was measured using the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR).

Results
Mean image quality and diagnostic confidence in evaluation of all shoulder structures were higher in DL sequences (p value = 0.01). Inter-reader agreement ranged between kappa values of 0.155 (assessment of the bursa) and 0.947 (assessment of the rotator cuff muscles). In 17 cases, thickening of the subacromial bursa of more than 2 mm was only visible in DL sequences. The pathologies of the other structures could be properly evaluated by conventional and DL sequences. Mean SNR (p value = 0.01) and CNR (p value = 0.02) were significantly higher for DL sequences.

Conclusions
The accelerated PROPELLER sequences with DL post-processing showed superior image quality and higher diagnostic confidence compared to the conventional PROPELLER sequences. Subacromial bursa can be thoroughly assessed in DL sequences, while the other structures of the shoulder joint can be assessed in conventional and DL sequences with a good agreement between sequences.

Key Points
• MRI of the shoulder requires long scan times and can be hampered by motion artifacts.
• Deep learning–based convolutional neural networks are used to reduce image noise and scan time while maintaining optimal image quality. The radial k-space acquisition technique (PROPELLER) can reduce the scan time and has potential to reduce motion artifacts.
• DL sequences show a higher diagnostic confidence than conventional sequences and therefore are preferred for assessment of the subacromial bursa, while conventional and DL sequences show comparable performance in the evaluation of the shoulder joint.
Increased IL-1α expression in chronic rhinosinusitis with nasal polyps
Authors: Cao Yujie , Hu Xianting , Zhou Chun , Zhao Keqing , Zheng Yaoming , Jiang Wenxiu , Wang Dehui , Li Huabin 
Published: September 2022

Abstract
Purpose
To examine whether and how interleukin (IL)-1α is involved in chronic rhinosinusitis with nasal polyps (CRSwNP).

Methods
Nasal polyp (NP) and control tissues were collected from CRSwNP patients and control subjects. The expression of IL-1α and other proinflammatory cytokines (IL-1β, IL-8 and IL-13, etc.), as well as neutrophil and eosinophil accumulation, were examined in sinonasal tissues using immunohistochemical (IHC), immunofluorescent (IF) staining, qPCR, and Luminex, respectively. Moreover, the regulation of IL-1α expression and its effects on other proinflammatory cytokines were evaluated in cultured nasal epithelial cells (NECs).

Results
The mRNA and protein levels of IL-1α were significantly higher in NP tissues compared to that in control tissues. IL-1α in polyp tissues was mainly located in epithelial cells and neutrophils. Polyps IL-1α level was significantly associated with IL-8, IL-1β, IL-6, IL-4 and IL-13 production, as well as tissue neutrophil infiltration. Moreover, poly (I:C), lipopolysaccharides, Flagellin, R848 and cytokines (IL-4, IL-5, and IL-13) significantly increased the expression of IL-1α in cultured NECs in vitro, and recombinant IL-1α significantly promoted production of IL-8 and CXCL1 in cultured NECs.

Conclusions
These findings provided the evidence that IL-1α were significantly increased in NP tissues, which may contribute to tissue neutrophilia in CRSwNP patients in China.
Freezing of gait is a risk factor for cognitive decline in Parkinson’s disease
Authors: Qu Yi , Li Jiangting , Chen Yupeng , Li Jingyi , Qin Qixiong , Wang Danlei , Zhao Jingwei , Yang Qingmei , Mao Zhijuan , Xiong Yongjie , Min Zhe , Xue Zheng 
Published: September 2022

Abstract
Backgrounds
Freezing of gait (FOG) and cognitive impairment are serious symptoms of Parkinson’s disease (PD). Understanding the association between FOG and cognition may help formulate specific interventions for PD individuals.

Objectives
We aimed to investigate the associations of cognitive impairment in different domains with FOG status using multiple neuropsychological tests.

Methods
Two cohorts including 691 and 104 participants were recruited from Parkinson’s progression markers initiative (PPMI) and central China, respectively. All participants underwent FOG assessment and neuropsychological tests, and 595 individuals from PPMI and 51 from central China were enrolled for longitudinal observation. Cross-sectional and longitudinal associations between cognition and FOG status were evaluated using multivariable-adjusted models.

Results
Worse cognitive performances were observed in patients with FOG compared to those without FOG in both cohorts (β = − 0.020, p < 0.001) using multivariate-adjusted models. Moreover, patients with progressive FOG during follow-up manifested more serious cognitive declines (HR = 1.40, 95% CI = 1.07–1.80). The FOG was mainly associated with the decline of executive, attention, and orientation. Furthermore, FOG was associated with higher levels of cognition-related biomarkers including T-tau, P-tau, and NfL in cerebrospinal fluid (p < 0.050).

Conclusions
FOG is a risk factor for cognitive decline in PD, which emphasizes the need for early detection and monitoring of cognitive changes and interventions on cognitive impairments in PD patients with FOG.
Bioenergy therapies as a complementary treatment: a systematic review to evaluate the efficacy of bioenergy therapies in relieving treatment toxicities in patients with cancer
Authors: Hauptmann M. , Kutschan S. , Hübner J. , Dörfler J. 
Published: September 2022

Abstract
Purpose
Bioenergy therapies are among the popular alternative treatment options for many diseases, including cancer. Many studies deal with the advantages and disadvantages of bioenergy therapies as an addition to established treatments such as chemotherapy, surgery, and radiation in the treatment of cancer. However, a systematic overview of this evidence is thus far lacking. For this reason, the available evidence should be reviewed and critically examined to determine what benefits the treatments have for patients.

Methods
In June 2022, a systematic search was conducted searching five electronic databases (Embase, Cochrane, PsychInfo, CINAHL and Medline) to find studies concerning the use, effectiveness and potential harm of bioenergy therapies including Reiki, Therapeutic Touch, Healing Touch and Polarity Therapy on cancer patients.

Results
From all 2477 search results, 21 publications with 1375 patients were included in this systematic review. The patients treated with bioenergy therapies were mainly diagnosed with breast cancer. The main outcomes measured were anxiety, depression, mood, fatigue, quality of life (QoL), comfort, well-being, neurotoxicity, pain, and nausea. The studies were predominantly of moderate quality and for the most part found no effect. In terms of QoL, pain and nausea, there were improved short-term effects of the interventions, but no long-term differences were detectable. The risk of side effects from bioenergy therapies appears to be relatively small.

Conclusion
Considering the methodical limitations of the included studies, studies with high study quality could not find any difference between bioenergy therapies and active (placebo, massage, RRT, yoga, meditation, relaxation training, companionship, friendly visit) and passive control groups (usual care, resting, education). Only studies with a low study quality were able to show significant effects.