bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychoeducational interventions to promote adolescents' mental health literacy in schools: Identifying theory for the development of a complex intervention
Authors: Morgado Tânia M. M. , Loureiro Luís M. J. , Rebelo Botelho Maria A. M. 
Published: June 2022

AbstractTopicThe concept of mental health literacy (MHL) was defined as the knowledge and beliefs about mental disorders that help in their recognition, management, or prevention. The complexity of interventions to promote adolescents' MHL requires that they be investigated through a process of development, feasibility/piloting, evaluation, and implementation, according to Medical Research Council (MRC) Framework.PurposeThis article aimed to identify the theory that supports the development of a psychoeducational intervention to promote adolescents' MHL in schools, possibly to be developed by mental health and psychiatric nurses.Sources UsedJournal articles, books, reports, and regulations.ConclusionsThis theory allows us to design a psychoeducational intervention to promote adolescents' MHL in schools and supports the subsequent phases of the MRC Framework.
Impact of left atrial low‐voltage areas during initial ablation procedures on very late recurrence of atrial fibrillation
Authors: Kanda Takashi , Masuda Masaharu , Asai Mitsutoshi , Iida Osamu , Okamoto Shin , Ishihara Takayuki , Nanto Kiyonori , Tsujimura Takuya , Matsuda Yasuhiro , Hata Yosuke , Uematsu Hiroyuki , Toyoshima Taku , Higashino Naoko , Mano Toshiaki 
Published: June 2022

AbstractBackgroundVery late recurrence of atrial fibrillation (VLRAF) occurring >1 year after catheter ablation may influence long‐term follow‐up strategies, including oral anticoagulant therapy. However, little is known about the predictors of this condition. Given that the prevalence of left atrial low‐voltage areas (LVAs) is strongly associated with the recurrence of atrial tachyarrhythmias following catheter ablation, we hypothesized that VLRAF might occur more frequently in patients with LVAs at the time of initial ablation. The purpose of this study was to investigate the impact of LVAs on VLRAF.MethodsThis study included 1001 consecutive patients undergoing initial ablation procedures for AF. LVAs were defined as regions with bipolar peak‐to‐peak voltages of <0.50 mV on the voltage map obtained during sinus rhythm after pulmonary vein isolation. During a 1‐year follow‐up period, 248 patients had a late recurrence of AF (LRAF), defined as recurrence within 3–12 months after ablation. The occurrence of VLRAF was examined in 711 patients without LRAF who were followed for more than 1 year.ResultsA total of 711 patients who did not develop AF recurrence within 1 year and for whom clinical data were available after 1 year were analyzed. During a median follow‐up of 25 (19, 37) months, VLRAF more than 1 year after the initial ablation was detected in 123 patients. On multivariate analysis, independent predictors of VLRAF were the existence of LVAs, female, left atrial diameter and early recurrence of AF. A Kaplan–Meier analysis showed that the AF‐free survival rate was significantly lower in patients with LVAs than in those without LVAs within 1 year and on more than 1‐year follow‐up (p < .001). An additional Kaplan–Meier analysis of the incidence of VLRAF in propensity score‐matched patients with and without LVAs showed that VLRAF occurred significantly more frequently in patients with LVAs (p = .003).ConclusionsLVAs during the initial AF ablation procedures have an impact on VLRAF occurrence.
Assessing cardiac mechanical dyssynchrony in left bundle branch area pacing and right ventricular septal pacing using myocardial perfusion scintigraphy in the acute phase of pacemaker implantation
Authors: Miyajima Keisuke , Urushida Tsuyoshi , Tamura Takumi , Masuda Sakito , Okazaki Ayako , Takashima Yasuyo , Watanabe Tomoyuki , Kawaguchi Yoshitaka , Wakabayashi Yasushi , Maekawa Yuichiro 
Published: June 2022

AbstractIntroductionLeft bundle branch area pacing (LBBAP) has recently been reported to be a new, clinically feasible and safe physiological pacing strategy. The present study aims to investigate the usefulness of LBBAP in reducing mechanical dyssynchrony compared with right ventricular septal pacing (RVSP).Methods and ResultsA total of 39 LBBAP patients, 42 RVSP patients, and 93 healthy control participants were retrospectively evaluated. We compared phase analysis‐ (bandwidth, phase standard deviation [PSD], entropy) and regional wall motion analysis parameters. Wall motion analysis parameters included the time to the end‐systolic frame (TES) assessed using single‐photon emission computed tomography analysis. The maximum differences between segmental TES (MDTES), the standard deviation of TES (SDTES), and the TES difference between the lateral and septal segments (DTES‐LS) were obtained. All phase analysis parameters were significantly smaller in the LBBAP group than in the RVSP group (bandwidth: LBBAP, 74 ± 31° vs. RVSP, 102 ± 59°, p = .009; PSD: LBBAP, 19 ± 6.7° vs. RVSP, 26 ± 15°, p = .007; entropy: LBBAP, 0.57 ± 0.07 vs. RVSP, 0.62 ± 0.11 p = .009). The regional wall motion analysis parameters were also smaller in the LBBAP group than in the RVSP group (MDTES:LBBAP, 17 ± 7.1% vs. RVSP, 25 ± 14%, p = .004; SDTES:LBBAP, 4.5 ± 1.7% vs. RVSP, 6.0 ± 3.5%, p = .015; DTES‐LS: LBBAP, 4.1 ± 3.4% vs. RVSP, 7.1 ± 5.4%, p = .004). All phase analysis and wall motion analysis parameters were same in the LBBAP and control groups.ConclusionLBBAP may reduce mechanical dyssynchrony and achieve greater physiological ventricular activation than RVSP.
Temporal and spatial pacemap parameters for identification of cardiac surfaces with critical sites for ventricular tachycardia
Authors: Ueda Akiko , Katsume Yumi , Miwa Yosuke , Mohri Takato , Tashiro Mika , Nonoguchi Noriko , Hoshida Kyoko , Togashi Ikuko , Sato Toshiaki , Soejima Kyoko ,   other members of the Multi‐surface PM study Group
Published: June 2022

AbstractIntroductionMultisurface pacemapping may help identify the surface of interest in scar‐related ventricular tachycardia (VT). This study aimed to investigate the performance of pacemap parameters for detecting critical sites through multisurface mapping.Methods and ResultsIn 26 patients who underwent scar‐related VT ablation, pacemap parameters including a matching score, the difference between the longest and shortest stimulus‐QRS intervals (Δs‐QRS), and the distance between the good pacemap sites were measured. The parameters were compared between surfaces with and without critical sites and ablation outcomes. A total of 941 pacemap at 56 surfaces targeting 35 VTs were analyzed. A greater Δs‐QRS (40 vs. 8 ms, p < .001) and longer distance between two good pacemap sites (24 vs. 13 mm, p < .001) were observed on the surfaces with critical sites. A similar trend was seen in multisurface pacemapping for the same VTs (52 vs. 18 ms in Δs‐QRS, p = .021; 37 vs. 12 mm in distance, p = .019), although the best pacemap scores were comparable (94 vs. 87, p = .295). The Δs‐QRS > 20 ms and the distance >19 mm showed high positive likelihood ratios (19.8 and 6.1, respectively) for discriminating the surface harboring the critical site. Ablation of VTs fulfilling these parameters was successful on the surfaces, but without the required multisurface ablation.ConclusionTemporal (Δs‐QRS) and spatial (distance) parameters for good pacemap match sites were excellent markers for detecting the surface harboring critical sites in scar‐related VT. A multisurface pacemapping can successfully identify the surface of interest.
Association between serum manganese levels and diabetes in Chinese adults with hypertension
Authors: Chen Hong , Cui Zhixin , Lu Wenhai , Wang Ping , Wang Jia , Zhou Ziyi , Zhang Nan , Wang Zhuo , Lin Tengfei , Song Yun , Liu Lishun , Huang Xiao , Chen Ping , Tang Genfu , Duan Yong , Wang Binyan , Zhang Hao , Xu Xiping , Yang Yan , Qin Xianhui , Song Fenglin 
Published: June 2022

AbstractManganese (Mn) is an essential trace metal element that is associated with diabetes; however, the results of previous studies are inconsistent. Furthermore, few studies have been conducted in a hypertensive population. The purpose of this study is to explore the relationship between manganese and diabetes in a population with hypertension. A cross‐sectional study was conducted, including 2575 hypertensive individuals from 14 provinces in China. Serum manganese concentrations were measured by the inductively coupled plasma mass spectrometry (ICP‐MS) method. And logistic regression models were used to analyze the association between serum manganese and the risk of diabetes. The prevalence of diabetes was 27.0% in this hypertensive population. In logistic regression models, the odds ratios (95% confidence interval) for diabetes in tertile subgroups were 1.40 (1.12, 1.76) and 1.32 (1.05, 1.65) for tertiles 1 and tertiles 3, respectively, compared to tertile 2 (reference). Additionally, an interaction between sex and manganese was observed. The odds ratios (95% confidence interval) for diabetes were 1.29 (0.95, 1.75) and 0.96 (0.70, 1.31) for tertiles 1 and tertiles 3 among males, and 1.44 (1.01, 2.04) and 1.81 (1.29, 2.55) for tertiles 1 and tertiles 3 among females, respectively, compared to tertile 2. In conclusion, a U‐shaped association between serum manganese and diabetes was observed in a Chinese population with hypertension, and the association was modified by sex.
Associations of blood pressure components with risks of cardiovascular events and all‐cause death in a Chinese population: A Prospective Study
Authors: Zhang Zhongying , Gu Xiang , Tang Zhe , Guan Shaochen , Liu Hongjun , Wu Xiaoguang , Zhao Yan , Fang Xianghua 
Published: June 2022

AbstractThe associations of blood pressure components with cardiovascular risks and death remain unclear, and the definition of wide pulse pressure (PP) is still controversial. Using data from 1257 participants without a history of cardiovascular disease, who were followed for 4.84 years, we performed multivariable Cox regression analyses to assess how systolic blood pressure (SBP), diastolic blood pressure (DBP), and PP contribute to risks of cardiovascular events and all‐cause death. Among all participants, SBP and PP were significantly associated with the risks of cardiovascular events and all‐cause death (all p < .05). DBP was not significantly associated with the risk of all‐cause death; rather, it was only associated with a marginally significant 1% increased risk for cardiovascular events (p = 0.051). In participants aged < 65 years, DBP was significantly associated with a 3% increased risk for cardiovascular events (hazard ratio [HR]: 1.03, 95% confidence interval [95% CI]: 1.01–1.06). The association between PP and cardiovascular events appeared to be J‐shaped in comparison to participants with the lowest‐risk PP (50–60 mmHg), with adjusted HRs of 1.71 (95% CI: 1.03–2.85), 1.63 (95% CI: 1.00–2.68), and 2.13 (95% CI: 1.32–3.43) in the <50, 60.0–72.5, and ≥72.5 mmHg subgroups, respectively. The optimal cutoff points of a wide PP for predicting the risks of cardiovascular events and all‐cause death were 70.25 and 76.25 mmHg, respectively. SBP and PP had a greater effect on cardiovascular risk, whereas DBP independently influenced cardiovascular events in middle‐aged participants. Considerable PP alterations should be avoided in antihypertensive treatment.
Time in range assessed by capillary blood glucose in relation to insulin sensitivity and β‐cell function in patients with type 2 diabetes mellitus: A cross‐sectional study in China
Authors: Ye Jingwen , Deng Jiajin , Liang Weiqiang , Luo Haizhao , Mei Wen , Liu Lei , Wang Mingzhu , Shu Yi 
Published: June 2022

ABSTRACTAimsThis study investigated the association of capillary blood glucose (CBG)‐assessed time in range (TIR) (3.9–10.0 mmol/L) with insulin sensitivity and islet β‐cell function.Materials and MethodsWe recruited 455 patients with type 2 diabetes mellitus. Seven‐point glucose‐profile data (pre‐ and 120 min post‐main meals, bedtime) were collected over three consecutive days. Plasma glucose and serum insulin concentrations were measured at 0, 60, and 120 min after a 100 g standard steamed bread meal test. The homeostasis model assessment of insulin resistance (HOMA‐IR) and Matsuda index were computed to evaluate insulin resistance. The HOMA of β‐cell function (HOMA‐β) and the area under the curve between insulin and blood glucose (IAUC0−120/GAUC0−120) were used to estimate β‐cell function.ResultsTIR was positively correlated with the 60 and 120 min insulin values, IAUC0−120, the Matsuda index, HOMA‐β, and IAUC0−120/GAUC0−120 (rs: 0.154, 0.129, 0.137, 0.194, 0.341, and 0.334, respectively; P < 0.05) but inversely correlated with HOMA‐IR (rs: –0.239, P < 0.001). After adjusting for confounders, multinomial multiple logistic regression analysis revealed that the odds ratios (ORs) of achieving the target time in range (>70%) increased by 12% (95% confidence interval [CI]: 3–21%), 7% (95% CI: 1–14%), 10% (95% CI: 5–16%), and 45% (95% CI: 25–68%) for each 10 mIU/L increase in the 60 and 120 min insulin values, 10 unit increase in HOMA‐β, and unit increase in IAUC0−120/GAUC0−120, respectively (P < 0.05). Nevertheless, the OR decreased by 10% (95% CI: 1–18%) for each unit increase in HOMA‐IR (P < 0.05).ConclusionsInsulin resistance and islet β‐cell function are related to capillary blood glucose‐assessed TIR.
Formulation of a new broad‐spectrum UVB + UVA and blue light SPF50+ sunscreen containing Phenylene Bis‐Diphenyltriazine (TriAsorB), an innovative sun filter with unique optical properties
Authors: Bacqueville D. , Jacques‐Jamin C. , Lapalud P. , Douki T. , Roullet N. , Sereno J. , Redoulès D. , Bessou‐Touya S. , Duplan H. 
Published: June 2022

AbstractAccumulating evidence from numerous comprehensive studies has demonstrated that blue light, in particular high‐energy visible light, can exert a range of harmful effects on skin cells. These forms of radiation are now known to be able to trigger oxidation reactions, DNA damage, erythema and pigmentary changes, and may also be associated with photoaging. Sunscreens protecting the skin from only ultraviolet (UV)‐B and UVA rays can therefore no longer be regarded as sufficient to help prevent skin damage from sunlight, and products containing filters that can provide broad‐spectrum photoprotection are required. To meet this need, a new sunscreen formulation that provides photoprotection against solar radiation with wavelengths ranging from UV to visible light has been developed, using an innovative organic sun filter with unique optical properties: phenylene bis diphenyltriazine (TriAsorB™). This article outlines the development and characteristics of this innovative filter and describes new key results from studies performed to assess the effectiveness and safety of the filter and the new sunscreen product. The studies conducted so far demonstrate that the filter has a good human and environmental safety profile. In addition, the sunscreen, which contains TriAsorB in combination with three other UV filters to offer broad‐spectrum sun protection with a high sun protection factor (SPF50+), appears to effectively prevent multiple forms of cellular photodamage, in particular blue light‐induced oxidatively generated DNA lesions. Overall, the available data indicate that regular use of the TriAsorB‐containing sunscreen could help prevent solar radiation‐induced skin damage and the development of signs of premature skin aging, as well as photodermatoses caused or exacerbated by visible light.
New insights from non‐invasive imaging: from prospection of skin photodamages to training with mobile application
Authors: Pellacani G. , Argenziano G. 
Published: June 2022

AbstractThe incidence of non‐melanoma skin cancer is on the rise and melanoma is among the most common cancers in the United States. Establishing an early diagnosis is essential for improving the prognosis of patients with skin cancer. High‐resolution non‐invasive imaging techniques may represent key tools for helping to identify and monitor early signs of skin cancer in seemingly healthy skin. Cumulative lifetime sun exposure leads to photoaging and photocarcinogenenis and the reaction of the skin to this solar‐induced damage is balanced between the DNA repair and photoprotection defence mechanisms of melanocytes and keratinocytes. In the first part of this article we provide an overview of these defence mechanisms and of the photoaging process, and discuss how non‐invasive imaging can be used to evaluate these changes. We then propose a model in which skin aging manifestations can be classified according to subject‐specific sun‐damage reaction profiles observed by reflectance confocal microscopy (RCM) and optical coherence tomography (OCT). These photoaging profiles include an atrophic phenotype characterized by actinic keratosis, and a hypertrophic phenotype characterized by hyperplastic pigmented skin. According to our model, these phenotypes may be predictive of predispositions to different types of skin cancer: squamous cell carcinoma for the atrophic phenotype and lentigo maligna and freckles for the hypertrophic phenotype. In addition to RCM and OCT, dermoscopy is another non‐invasive technique that has improved the diagnosis of skin cancer. In the second part of this article, we describe how the YouDermoscopy™ application can improve skills and thus enhance the dermoscopic recognition of sun‐induced skin tumours, and then show how this training tool enables its users to collaborate with dermatologists worldwide to obtain second opinions for the diagnosis of ambiguous lesions. Altogether, RCM, OCT and dermoscopy are valuable tools that can contribute significantly to improving the early diagnosis of precancerous and cancerous lesions.
Children with psoriasis and COVID‐19: factors associated with an unfavourable COVID‐19 course, and the impact of infection on disease progression (Chi‐PsoCov registry)
Authors: Zitouni J. , Bursztejn A.‐C. , Belloni Fortina A. , Beauchet A. , Di Lernia V. , Lesiak A. , Thomas J. , Topkarci Z. , Murashkin N. , Brzezinski P. , Torres T. , Chiriac A. , Luca C. , McPherson T. , Akinde M. , Maruani A. , Epishev R. , Vidaurri de la Cruz H. , Luna P.C. , Amy de la Bretêque M. , Lasek A. , Bourrat E. , Bachelerie M. , Mallet S. , Steff M. , Bellissen A. , Neri I. , Zafiriou E. , van den Reek J.M.P.A. , Sonkoly E. , Mahil S.K. , Smith C.H. , Flohr C. , Bachelez H. , Mahé E. ,   the Groupe de Recherche sur le Psoriasis (GrPso) of the Société Française de Dermatologie, the Groupe de recherche de la Société Française de Dermatologie Pédiatrique (GR SFDP), the PsoProtect study group, the British Society of Paediatric Dermatology (BPSD), and the Società Italiana di Dermatologia Pediatrica (S.I.Der.P.)
Published: June 2022

AbstractBackgroundThe COVID‐19 pandemic has raised questions regarding the management of chronic skin diseases, especially in patients on systemic treatments. Data concerning the use of biologics in adults with psoriasis are reassuring, but data specific to children are missing. Moreover, COVID‐19 could impact the course of psoriasis in children.ObjectivesThe aim of this study was therefore to assess the impact of COVID‐19 on the psoriasis of children, and the severity of the infection in relation to systemic treatments.MethodsWe set up an international registry of paediatric psoriasis patients. Children were included if they were under 18 years of age, had a history of psoriasis, or developed it within 1 month of COVID‐19 and had COVID‐19 with or without symptoms.ResultsOne hundred and twenty episodes of COVID‐19 in 117 children (mean age: 12.4 years) were reported. The main clinical form of psoriasis was plaque type (69.4%). Most children were without systemic treatment (54.2%); 33 (28.3%) were on biologic therapies, and 24 (20%) on non‐biologic systemic drugs. COVID‐19 was confirmed in 106 children (88.3%) and 3 children had two COVID‐19 infections each. COVID‐19 was symptomatic for 75 children (62.5%) with a mean duration of 6.5 days, significantly longer for children on non‐biologic systemic treatments (P = 0.02) and without systemic treatment (P = 0.006) when compared with children on biologics. The six children who required hospitalization were more frequently under non‐biologic systemic treatment when compared with the other children (P = 0.01), and particularly under methotrexate (P = 0.03). After COVID‐19, the psoriasis worsened in 17 cases (15.2%). Nine children (8%) developed a psoriasis in the month following COVID‐19, mainly a guttate form (P = 0.01).DiscussionBiologics appear to be safe with no increased risk of severe form of COVID‐19 in children with psoriasis. COVID‐19 was responsible for the development of psoriasis or the worsening of a known psoriasis for some children.
Inflammation and thrombo‐occlusive vessel signalling in benign atrophic papulosis (Köhlmeier–Degos disease)
Authors: Zouboulis C.C. , Theodoridis A. , Makrantonaki E. 
Published: June 2022

AbstractBackgroundAlthough the merely cutaneous, benign form of the extremely rare disease atrophic papulosis (Köhlmeier–Degos disease) may occasionally develop into the systemic, malignant form with time, it is unclear whether it exhibits any systemic characteristics.ObjectiveTo determine whether benign atrophic papulosis exhibits inflammatory and thrombo‐occlusive signals and to classify it according to the Chapel‐Hill classification of vasculitis.MethodsIn a monocentric, controlled study, levels of cytokines (IL‐1β, IL‐6, IL‐8, IFNγ, MCP‐1, VEGF, TNFα, TGF‐β1), antiphospholipid antibodies (cardiolipin IgG/A/M, cardiolipin IgG, cardiolipin IgM, β2‐glycoprotein IgG/A/M, phosphatidyl choline, phosphatidyl serine, phosphatidyl inositol, phosphatidyl ethanolamine and sphingomyelin A), antibodies against proteinase‐3 IgG and myeloperoxidase IgG, antinuclear antibodies and extractable nuclear antigen were assessed in blood samples of six benign atrophic papulosis patients and six age‐ and sex‐matched healthy controls.ResultsIL‐8 was only detectable in patients' serum. VEGF was reduced and cardiolipin IgG/A/M and β2‐glycoprotein antibodies were increased in the patients' group. ANA were only detected in three patients, and ENA were negative throughout. No differences were detected between the other investigated markers.ConclusionsThis is the first study evaluating systemic inflammatory and thrombo‐occlusive vessel signalling in benign atrophic papulosis and provides evidence of a non‐antineutrophil cytoplasmatic antibodies immune‐complex small vessel vasculitis according to the Chapel‐Hill classification. These findings corroborate its systemic character despite the apparent missing involvement of systemic organs.
Balancing clinical needs and probation requirements within CSEC specialty courts
Authors: Gale‐Bentz Elizabeth , Iturri Florencia , Wheeler Tracey , Nelke Connie F. 
Published: June 2022

AbstractAs juvenile justice systems across the country explore ways to best serve youth who have been commercially sexually exploited, challenges may arise between youths' clinically indicated needs and the probation‐driven requirements of CSEC specialty court involvement. This article explores some of the clinical‐probation dualities CSEC specialty courts may encounter, conceptualized as tensions related to issues of confidentiality, responses to behaviors that jeopardize youths' safety, and the timing of healing. Future directions for consideration to better meet the needs of youth involved in the justice system who have experienced sexual exploitation are also discussed.