bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENDAMPINGAN SOSIALISASI PERAN UMKM DALAM PENINGKATAN EKONOMI KELUARGA DI WARGA RW.001 KECAMATAN BATU AJI KELURAHAN BUKIT TEMPAYAN KOTA BATAM
Authors: Marpaung Junierissa , Ramli Rimayang Anggun , Ariyati Yannik , Sinaga Juwita Boneka 
Published: September 2022

Pengabdian masyarakat ini bertujuan untuk memberikan wawasan pengetahuan tentang meningkatkan ekonomi keluarga melalui UMKM. Dengan pengabdian masyarakat ini diharapkan ekonomi keluarga dapat meningkatkan melalui UMKM atau pemberdayaan UMKM agar semakin menarik. Sosialisasi ini dilakukan untuk memberikan pemahaman bagi warga RW.001 Kecamatan Batu Aji Kelurahan Bukit Tempayan dan pelaku UMKM terkait dengan berbagai peluang usaha UMKM dan ekonomi kreatif di masa krisis, masa krisis adalah masa berlangsungnya pandemic Covid-19. Warga RW.001 Kecamatan Batu Aji Kelurahan Bukit Tempayan diberikan motivasi untuk lebih mengedepankan inovasi dan orientasi global sesuai kebutuhan masyarakat. Sosialisasi ini juga memaparkan pentingnya marketing digital sebagai bentuk promosi penjualan ke masyarakat yang lebih luas. Persiapan dilakukan dengan melakukan survei pendahuluan untuk melihat kondisi di lapangan mengenai masalah yang dihadapi masyarakat. Pelaksanaan dilakukan dengan memberikan layanan informasi dengan menggunakan metode ceramah berupa sosialisasi yaitu dengan teknik presentase, dilanjutkan dengan diskusi dan tanya jawab. Hasil kegiatan sosialisasi menunjukkan bahwa: (1). Program pengabdian pada masyarakat dengan kegiatan sosialisasi tentang meningkatkan ekonomi keluarga melalui peran UMKM di RW 01 Kelurahan BukitTempayan Kota Batam dapat terlaksanakan dan direspon dengan baik. (2). Pelaksanaan program pengabdian pada masyarakat ini sangat bermanfaat bagi masyarakat sehingga dapat diterapkan para warga dengan meningkatkan UMKM yang sudah ada seperti melakukan pemasaran secara online, memperbaiki kemasan agar lebih menarik.
Pengaruh Pupuk Organik Cair Kulit Pisang Kepok (Musa paradisiaca L.) terhadap Pertumbuhan Bayam Cabut (Amaranthus tricolor L.) dan Implementasinya dalam Video Pembelajaran
Authors: Syamsi Fauziah , Kiptiyah Kiptiyah , Efendi Yarsi 
Published: September 2022

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian pupuk organik cair kulit pisang kepok (Musa paradisiaca L.) terhadap pertumbuhan tanaman bayam cabut (Amaranthus tricolor L.). Rancangan yang digunakan dalam penelitian ini adalah Rancangan Acak Lengkap (RAL) dengan 1 kontrol, perlakuan A (dosis 10 ml), perlakuan B (dosis 15 ml), perlakuan C (dosis 20 ml), perlakuan D (dosis 25 ml), dan perlakuan E (30 dosis ml); masing-masing perlakuan diulang sebanyak 5 kali, sehingga terdapat 30 satuan pecobaan. Variabel yang dianalisis adalah tinggi tanaman, jumlah daun dan berat basah. Data yang diperoleh dari penelitian ini dianalisis dengan ANOVA (Analysis of varience) dan apabila perlakuan berpengaruh nyata, maka akan dilanjutkan dengan uji BNT (Beda Nyata Terkecil) pada taraf 5%. Hasil analisis menunjukkan bahwa terdapat pengaruh yang nyata dari pemberian pupuk organik cair kulit pisang kepok terhadap variabel pertumbuhan tinggi bayam cabut (Fhitung = 4.637 FTabel (0.05) = 2.62), tidak terdapat pengaruh nyata terhadap varibel jumlah daun bayam cabut (Fhitung = 1.855 FTabel (0.05) = 2.62), dan tidak tidak terdapat pengaruh nyata terhadap variabel berat basah bayam cabut (Fhitung = 1.011 FTabel (0.05) = 2.62).
Wild Edible Plants Sebagai Pendukung Ketahanan Pangan Pada Masyarakat Desa Kebondalem Kecamatan Bangorejo Kabupaten Banyuwangi
Authors: Nurchayati Nunuk 
Published: September 2022

Masyarakat di desa tersebut seringkali memenuhi kebutuhan pangannya dengan memanfaatkan tumbuhan liar. Tujuan penelitian ini adalah untuk mengetahui jenis tumbuhan liar yang dimanfaatkan untuk memenuhi kebutuhan pangan oleh masyarakat desa Kebondalem kecamatan Bangorejo Kabupaten Banyuwangi. Penelitian ini menggunakan metode penelitian kuantitatif secara purposive snaowball sampling dan cara perolehan informasi dengan teknik wawancara. Tahapan penelitian meliputi studi pendahuluan, studi etnobotani, pengumpulan data tumbuhan, dan analisis data secara kuantitatif. Kesimpulan dari penelitian menunjukkan bahwa tumbuhan liar yang dimanfaatkan oleh masyarakat desa Kebondalem berjumlah 14 spesies dan tergabung dalam 10 famili dengan 7 kategori (lalapan, sayur tawar, sayur bersantan, sayur bening, tumisan, botok, dan bahan makanan pokok). Nilai sitasi masyarakat tertinggi (100%) adalah untuk tumbuhan lompong (Colocasia esculenta) dan terendah (28,3%) tumbuhan luntas (Pluchea indica). Sedangkan nilai RKI yang tertinggi (1) kategori lalapan dan yang terendah (0,74) kategori botok. Organ yang dimanfaatkan meliputi, batang, daun, buah, dan umbi. Habitat tumbuhan liar yang diperoleh berasal persawahan (14,29%), ladang (28,57%), pekarangan sekitar rumah (35,71%), dan di gunung Srawet (21,43%).
Comparative Study of Rheological Properties of Gels and Creams on Different Carrier Bases
Authors: Nogaeva U. V. , Naumova A. A. , Novinkov A. G. , Flisyuk E. V. , Burakova M. A. , Shikov A. N. , Abrosimova O. N. 
Published: September 2022

Introduction. The study of rheological properties (dynamic and plastic viscosity, yield strength, the degree and presence of a thixotropic effect, the nature of the type of flow) are important for the development of soft dosage forms. These properties affect the stability of the dosage form during storage, its technological and consumer characteristics .Aim. Study of the main rheological parameters of the developed gels and creams on various carrier bases.Materials and methods. Meloxicam as active ingredient and excipients: sodium alginate, twin-80, propylene glycol, cremophor, glycerin, essential oils of lemon and orange, carbopol 980, polyethylene glycol-400 (PEG-400), viburnum bark, chamomile flowers, chlorhexidine bigluconate 20 %, menthol, sorbitol, corn oil, distilled monoglycerides (MHD), cetyl alcohol, coconut oil, salicylic acid, emulsion wax, preparation OS-20, triethanolamine (TEA), and euxil PE 9010 were used for the preparation of ex[eroimental samples. Three laboratory samples of soft formulations with the mass of 100 g each were prepared. The rheological properties of the samples were tested 24 hours after their preparation using Anton Paar DV-2P viscometer (Anton Paar GmbH, Austria), spindle L4. The structural and mechanical properties of the samples were tested using a device designed at the St. Petersburg State Chemical and Pharmaceutical University under thesupervision of Professor, Doctor of Pharmaceutical Sciences V. A. Vainshtein.Results and discussion. The greatest mechanical stability was observed for the sample No. 1 (gel based on alginate) and sample No. 3 (cream). The ascending and descending hysteresis loop curves indicates that the test samples have thixotropic properties. Samples No. 1 and 2 have upward and downward flow curves superimposed on each other.This phenomenon is typical for all gels and is their feature. The relaxation of the structure of an elastic-plastic material after the deformation caused by the introduction of a tester stock occurs according to the logarithmic law. At rest, when the tester stockis not introduced into the material, the structure of tested samples is intact and samples has a maximum density (static viscosity). The introduction of the tester stock into the sample results in plastic deformation and forced flow. The tension at the moment of tester stock introduction reflects the yield strength.Further, with the immersed tester devoce, a thixotropic recovery of the destroyed structural bonds occurs. Such a pattern in the dynamics of structure resistance is observed for structured (non-Newtonian) liquids.Conclusion. The rheological properties of three experimental soft formulations made on different carrier bases were investigated. The importance of rheological studies in the drug development of high e quality soft formulations was shown.
Research of <I>Rhodiola rosea</I> Rhizomes and Roots Using High Performance Thin Layer Chromatography
Authors: Sklyarevskaya N. V. , Alexeeva Yu. S. , Ponkratova A. O. , Zhokhova E. V. 
Published: September 2022

Introduction. The research results obtained through the analysis of different varieties of Rhodiola rosea rhizomes and roots using high-performance thin layer chromatography (HPTLC), grown in the Saint-Petersburg State Chemical-Pharmaceutical University (SPCPU) medicinal plants nursery garden, are represented.Aim. To carry out a comparative analysis of Rhodiola rosea rhizomes and roots samples, grown in the SPCPU medicinal plants nursery using HPTLC.Materials and methods. HPTLC analysis was performed on a CAMAG device (Switzerland), using MERCK HPTLC silica gel 60 F 254, 20 × 10 cm plates. Extracts were obtained from raw materials using an ultrasonic bath "Sapphire-4.0 TTC" (Russia). The Rhodiola rosea rhizomes and roots were harvested in the SPCPU medicinal plants nursery garden (Leningrad Region, Vsevolozhsk district, Priozerskoe Highway, 38 km) in August 2019.Results and discussion. In the course of the research, extracts from Rhodiola rosea rhizomes and roots were obtained using 70 % ethyl alcohol and methyl alcohol as extractants. The extracts were investigated by HPTLC in ethyl acetate – methanol – water – formic acid (77 : 13 : 10 : 2) solvent system. After scanning densitometric analysis at 254 nm, the much better separation of methanol extracts in this solvent system was found than ethanol extracts. The densitograms of individual tracks were compared with each other in order to identify samples of Rhodiola rosea rhizomes and roots with a higher biologically active compounds content. As a result of the comparison of 18 samples tracks of the Rhodiola rosea rhizomes and roots (the extractant was ethyl alcohol 70 %), samples № 6 and 17 have been proposed as promising for further research and cultivation.Conclusion. As a result of the analysis of alcohol extracts from Rhodiola rosea rhizomes and roots by HPTLC, the samples 6 (Tomsk, Russia) and 17 (Valla Di Aposta/Hirvos varieties, country of origin – Italy/Finland) were found to have a higher content of biologically active compounds.
Caco-2 Intestinal Permeability Study of Phenyltetrahydroquinolinedione Derivative – TRPA₁ Antagonist
Authors: Pyatigorskaya N. V. , Kravchenko A. D. 
Published: September 2022

Introduction. This work is devoted to the intestinal permeability study of 7-(2-chlorophenyl)-4-(4-methyl-1,3-thiazol-5-yl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione – innovative biologically active substance with TRPA1 antagonist activity. The phenyltetrahydroquinolinedione derivative is a promising analgesic and anti-inflammatory drug. To develop a dosage form of this new substance, it is necessary to study the mechanism and degree of its absorption.Aim. The aim of this work was to investigate the intestinal permeability of the phenyltetrahydroquinolinedione derivative using Caco-2 cell model and to compare experimental results with the in silico obtained values of the octanol/water partition coefficients.Materials and methods. The study of permeability was carried out from the apical membrane to the basolateral (A-B) and in the opposite direction (B-A). Ranitidine (low permeability), propranolol (high permeability) and rhodamine 123 (P-glycoprotein substrate) were used as control compounds. The concentration of the test compound was determined by UHPLC-MS/MS system consisting of a liquid chromatograph and a tandem mass spectrometer with a triple quadrupole and an electrospray ion source. The logP was calculated using the following resources: ChemDraw Professional 16.0, Molinspiration, ALOGPS 2.1.Results and discussion. The values of the apparent permeability (Papp) and efflux ratios of the test and control compounds were obtained. According to the results of the study, the following conclusions were made: the test compound has high permeability both in the forward direction from the apical to the basolateral cell membrane, and in the opposite direction (Papp > 10 × 10-6 cm/s). P-glycoprotein-mediated efflux activity was not observed (the efflux ratio was less than 2 units). The permeability did not depend on the test compound input concentration. The obtained experimental Papp values were correlated with the in silico obtained values of partition coefficients. The best correlation was obtained for milogP (Molinspiration) and ClogP (ChemDraw).Conclusion. Thus, the in vitro and in silico obtained data indicate that passive diffusion is the main mechanism of absorption of the test compound in the gastrointestinal tract.
Development of a Method and a Scheme for the Use of a Live Recombinant Vaccine "GamLPV". Safety and Tolerability of Double Intranasal Vaccination of Healthy Adult Volunteers
Authors: Karataev G. I. , Medkova A. Yu. , Semin E. G. , Sinyashina L. N. , Sioundioukova R. A. , Kulikov S. V. , Snegireva N. A. , Chernishova I. N. , Gavrilova M. V. , Bushkova K. K. , Lidzhieva A. A. , Kolobukhina L. V. , Kruzhkova I. S. , Merkulova L. N. , Rusanova M. G. , Bazarova M. V. , Antipyat N. A. , Smetanina S. V. , Smolyarchuk E. A. , Dyakov I. N. 
Published: September 2022

Introduction. The increase in the incidence of whooping cough in children and adults of different age groups justifies the need for their revaccination and the development of new, acceptable for these purposes. This work is devoted to substantiating the design of a clinical trial and describing the results of a comparative study of the safety and tolerability of the drug "GamLPV" with two-fold intranasal administration to healthy adult volunteers using two methods. The choice of the scheme and method of administration of the drug is justified. The serological structure of the population of adults aged 18–40 years living in Moscow and the Moscow region is characterized.Aim. Determination of the safety and tolerability of the drug with a double intranasal administration of the vaccine by drip method and spraying through an actuator.Materials and methods. A randomized placebo-controlled trial included 50 healthy male and female volunteers aged 18 to 40 years who met the inclusion criteria. The volunteers were divided into 2 groups of 25 people: a drip method of administration and spraying through an "actuator". By both methods, the drug was administered twice with an interval of 60 days.Results and discussion. Serological analysis of the population of healthy volunteers at the prescreening stage justified the inclusion in the study of volunteers containing anti-pertussis antibodies in the blood (IgG ≤40 Ed/ml). A comparison of the results of preclinical studies on an experimental model of non-human monkeys and the first phase of a clinical study of GamLPV allowed us to propose two methods of double administration of the drug as a promising vaccination scheme for volunteers. A comparative randomized study shows the safety of using the proposed scheme for vaccination of adult volunteers.Conclusions. Both proposed methods of double administration can be used to plan a multicenter study to research the immunogenicity and protective activity of GamLPV.
Issues of National Drug Security in Formation of a Reserve of Antibacterial Agents Intended to Eliminate Medical and Sanitary Consequences of Emergencies
Authors: Chernikova L. Yu. , Dmitruk V. N. , Denisov N. L. , Morozova E. G. , Ratkin A. V. , Karakulova E. V. 
Published: September 2022

Introduction. The article considers the issues of forming a reserve of antibacterial agents designed to eliminate medical and sanitary consequences of emergencies from the perspective of national drug security.Aim. To determine the degree of import substitution of antibacterial agents included in the regional drug reserve.Materials and methods. We carried out a content analysis of data from regulatory documents and research papers related to formation of drug reserves, a logical and structural analysis of the range of antibacterial agents included in the reserve of the Tomsk region, and an analysis of data from the National Drug Register. In the study, we used the Anatomical Therapeutic Chemical (ATC) Classification System of drugs.Results and discussion. It was established that for 19 international nonproprietary names (INN) of antibacterial agents belonging to the group of antibacterials for systemic use (ATC code J01) and forming the reserve of the Tomsk region, 294 brand names (BN) were registered on the pharmaceutical market of the Russian Federation in 2021. The share of registered domestic BN was 49.3 %, and the degree of import dependence of domestic drug manufacturing on foreign-made active pharmaceutical ingredients (APIs) was 81.4 %. It was found that 6 Russian enterprises manufacture APIs that supply production of 10 antibacterial agents included in the drug reserve. A classification of medicines by strategic availability for replenishing the drug reserve was developed. A map on strategic availability of domestically manufactured antibacterial agents included in the reserve was drawn up.Conclusion. We demonstrated high dependence of antibacterial reserve formation on import of this group of medicines and APIs to the Russian Federation. The classification of medicines which takes into account the possibility of replenishing the drug reserve in emergency conditions and if import of medicines stops can be recommended for use by the center for disaster medicine to optimize the nomenclature of drug reserves at various levels from the perspective of national drug security promotion.
Respuesta del cultivo del tomate (Solanum lycopersicum L.) a la aplicación de QuitoMax® en condiciones de salinidad
Authors: Amador Carlos Ávila , Algentel-Martínez Leandris , Peñuelas-Rubio Ofelda , González Aguilera Jorge , Reyna Idalmis Fonseca 
Published: September 2022

Se estudió el efecto del QuitoMax® en el comportamiento de plantas de tomate de las variedades Claudia y Amalia en condiciones estrés salino. El experimento se desarrolló en el municipio Cauto Cristo provincia de Granma en el período de octubre de 2017 a marzo de 2018, en un suelo clasificado como salino sódico (CE 4 dS m-1). El diseño experimental utilizado fue de bloques al azar, con arreglo factorial, replicando cuatro veces cada variante. Se aplicó el bioestimulante a los 12 días después del trasplante (DDT) a razón de 300 y 400 mg ha-1 y el control (cero aplicación). Fueron evaluados, a los 45 DDT, la altura de la planta, la longitud de la raíz, el número de frutos, el número de racimos por plantas, el diámetro ecuatorial, el diámetro polar y el rendimiento. La aplicación del bioestimulante QuitoMax® incrementa el número de racimos por planta y la masa de los frutos del tomate en condiciones de salinidad comparados con el control. Se incrementaron los rendimientos agrícolas en un 43% y 76%, así como, los beneficios económicos en 1653.93 $ ha-1 y en 3418.08 $ ha-1 respecto al control, para las cultivares Amalia y Claudia, respectivamente, cultivadas en condiciones de salinidad. Los mejores resultados se obtuvieron al aplicar la dosis de 300 mg ha-1 de QuitoMax®.
Conhecimento e práticas maternas sobre alimentação complementar em crianças de zero a dois anos de idade
Authors: Leandro Camila Almeida , Santos Maria Solange Nogueira dos , Santos Aliniana da Silva , Rodrigues Lidiane do Nascimento , Silva Vanusa Maria Gomes Napoleão , Freitas Samara Hellen Nogueira de , Albuquerque Firmina Hermelinda Saldanha , Chaves Edna Maria Camelo 
Published: September 2022

Este estudo objetivou conhecer as práticas maternas sobre alimentação complementar em crianças de zero a dois anos de idade. Trata-se de um estudo descritivo de abordagem qualitativa, desenvolvido em uma Unidade de Atenção Primária em Saúde (UAPS) na cidade de Fortaleza-CE, Brasil. A unidade escolhida faz parte da área de abrangência e reponsabilidade sanitária da Universidade Estadual do Ceará (UECE), sendo campo de prática dos discentes do curso de enfermagem da referida universidade. A pesquisa seguiu o referencial de estudos de melhoria da qualidade COREQ da rede EQUATOR. Participaram inicialmente do estudo 20 mães, escolhidas por conveniência, sendo amostra final 19 mães. A coleta ocorreu no mês de setembro de 2018 através de uma entrevista semiestruturada. As respostas foram gravadas, com duração média de dez minutos. As informações foram transcritas para organização do corpus textual, analisadas e processadas pelo software IRAMUTEQ. O corpus textual foi composto por 88 seguimentos, dos quais se obtiveram 68 Unidades de Contexto Elementar, produzindo seis classes: alimentos ofertados, orientações, conhecimento das mães, facilidades das mães, dificuldades das mães, sentimentos maternos. O estudo mostrou que as mães têm conhecimento sobre a introdução alimentar nas crianças menores de 2 anos, no entanto o início desses alimentos complementares são difíceis, pois surgem os sentimentos de medo e dúvida, principalmente a ansiedade e a insegurança relacionadas a adaptação da criança com as novas descobertas alimentares, partindo desses anseios, nessa nova fase da vida da criança, é preciso que os profissionais ofereçam uma rede de apoio de orientações e esclarecimentos às mães e/ou aos responsáveis pela criança.
Ser joven privado de la libertad en ciudades del norte de México
Authors: Rivera García Óscar Bernardo 
Published: September 2022

The objective of this article is to analyze the narratives of four young people from border cities who were deprived of their liberty for having proven their participation in a crime. The narratives are approached from a qualitative perspective to delve into the meanings involved in building identities in a border context. The field work was developed during 2018 and 2019 in the treatment centers for adolescents in San Luis Río Colorado and Nogales, Sonora, as well as in Güémez, Tamaulipas, Mexico. One of the substantive findings was to identify the process of internalization and normalization of a state of permanent precariousness in the actors in the absence of structural strategies that homogenize the youth. The analysis from these dimensions provides empirical elements in the discussion about heterogeneities in youth identities; elements for an epistemological, holistic and situational discussion on the accumulation of situations of vulnerability that certain actors experience in a given geographic space.