bluuebunny/crossref_metadata_2025_split huggingface dataset:
Die Rolle des Hautmikrobioms bei atopischer Dermatitis – Zusammenhänge und Konsequenzen
Authors: Fölster‐Holst Regina 
Published: May 2022

ZusammenfassungDie physikalische Barrierefunktion der Haut wird maßgeblich unterstützt durch das (epi‐) dermale Immunsystem sowie das hauteigene Mikrobiom. Bei atopischer Dermatitis geraten alle drei Faktoren aus dem Gleichgewicht. Das Hautmikrobiom etabliert sich unmittelbar nach der Geburt und spielt eine wichtige Rolle für die Entwicklung und Aufrechterhaltung einer Immunhomöostase. Das Krankheitsbild der atopischen Dermatitis ist unter anderem durch Veränderungen des Hautmikrobioms gekennzeichnet. Insbesondere während eines akuten Schubs lassen sich eine stark verminderte bakterielle Diversität sowie die Dominanz eines einzelnen Pathogens, Staphylococcus aureus, beobachten. Staphylococcus aureus verschlimmert das entzündliche Geschehen und schwächt durch Proteasen und Toxine die ohnehin stark beeinträchtigte Barrierefunktion der Haut von Patienten mit atopischer Dermatitis. Aus dem Wissen um die dermale Dysbiose ergeben sich für die Therapie der Erkrankung jedoch auch neue Behandlungsoptionen. Insbesondere die Anwendung lebender Bakterien stellt eine unmittelbare Beeinflussung des Hautmikrobioms dar. In ersten klinischen Untersuchungen haben verschiedene Ansätze vielversprechende Ergebnisse demonstrieren können, dieser Artikel gibt einen Überblick über die Arbeiten auf diesem Gebiet.
Psoriasis‐Therapie während Schwangerschaft und Stillzeit
Authors: Balakirski Galina , Gerdes Sascha , Beissert Stefan , Ochsendorf Falk , von Kiedrowski Ralph , Wilsmann‐Theis Dagmar 
Published: May 2022

ZusammenfassungIm letzten Jahrzehnt wurden zahlreiche neue Systemtherapien für die Psoriasis vulgaris und Psoriasisarthritis (PsA) zugelassen. Dennoch sind Therapieentscheidungen bei Frauen mit Kinderwunsch sowie bei schwangeren und stillenden Frauen aufgrund der schwachen Datenlage schwer zu treffen. Die umfangreichste Erfahrung zur Psoriasistherapie während einer Schwangerschaft besteht für die topische Anwendung von Corticosteroiden und gehört somit zur Basisversorgung. Die medizinisch kontrollierte Anwendung der UV‐Lichttherapie in der Schwangerschaft gilt als unbedenklich. Die beste Evidenzlage bezüglich systemischer Therapie während Schwangerschaft und Stillzeit liegt für TNF‐α‐Inhibitoren vor und fand Eingang in die jeweiligen Fachinformationen. Dies ist umso wichtiger bei begleitender PsA. Unter den traditionellen Systemtherapeutika besteht zu Ciclosporin die umfangreichste Kenntnis; es muss bei medizinischer Notwendigkeit während der Schwangerschaft nicht abgesetzt werden. TNF‐α‐Blocker, insbesondere die pegylierte Form, würden aber bei Neueinstellung priorisiert werden. Allerdings besteht bei vielen weiteren Systemtherapien im Falle einer (ungeplant) aufgetretenen Schwangerschaft keine zwingende Indikation zum Schwangerschaftsabbruch. Die vorliegende Arbeit stellt eine Zusammenfassung der aktuellen Evidenz dar und soll eine individuelle Entscheidungsfindung unterstützen. Nach ausführlicher Aufklärung der Patientinnen und ihrer Partner kann somit unter Berücksichtigung aller Faktoren (wie Komorbidität, Krankheitsschwere, Verlauf vorheriger Schwangerschaften) eine gemeinsame Entscheidung zur geeigneten Therapie getroffen werden.
Longitudinal study of Spanish Dual Language Immersion graduates: Secondary school academic and language achievement
Authors: Padilla Amado M. , Chen Xinjie , Swanson Elizabeth , Peterson Margaret , Peruzzaro Amy 
Published: May 2022

AbstractFive cohorts of students (N = 322) who completed a K–5 Spanish Dual Language Immersion (DLI) program in an urban school district were followed longitudinally through middle and high school completion. Academic and language achievement data included English Language Arts and Mathematics scores on the Standardized Testing and Reporting (STAR) test for grades 3–8 and on the California Assessment of Student Performance and Progress (CAASPP) for 11th grade, 10th‐grade cumulative high school grade point average, enrollment in and grades earned in language classes, and attainment of the California Seal of Biliteracy. The DLI students were compared to non‐DLI students who attended the same schools. Most DLI students continued with advanced level classes in Spanish in high school, and nearly half earned the California Seal of Biliteracy. Achievement results indicate that DLI graduates performed at equivalent or higher levels than non‐DLI students on standardized achievement measures for English Language Arts and Mathematics.
How do emerging market suppliers reshape the governance of global value chains? Evidence from China
Authors: Ma Huanhuan , Su Jingqin , Gao Xin , Wang Na 
Published: May 2022

AbstractThe growth in the number of emerging market firms with a global presence highlights the need to better understand how suppliers influence the governance in global value chains (GVCs). However, existing frameworks do not sufficiently elaborate this phenomenon's standing at firm level. Using a multi‐case study of six suppliers in China, this research explains how suppliers can reshape the governance structure with capability development, and thus change the power balance in GVCs. This study highlights governance changes from a supplier‐centric perspective: external governance with decentralized control and internal governance with control integration. More specifically, through the underlying mechanism from a value‐based perspective, suppliers can take greater control of specific value chain activities and move from being a value creator to becoming a value innovator.
Gender system and corruption: Patriarchy as a predictor of “fairness”
Authors: Ottervik Mattias , Su Zheng 
Published: May 2022

AbstractThis article tests gender system as a mediator in the relationship between gender and corruption. Using data from World Values Survey we find a robust, significant link between acceptance of patriarchy and acceptance of corruption. We also find a significant link between acceptance of male superiority and acceptance of corruption. In the relationship between gender and attitudes toward corruption, gender system is a consistently statistically significant predictor of acceptance of corruption whereas gender is not. The predictive power of acceptance of patriarchy and male superiority on corruption holds even with extensive controls. These results provide insight into the link between gender and corruption and suggest some of the wide‐ranging effects of gender system on the political system.
A prospective cohort study of renal function and bone turnover in adults with hepatitis B virus (HBV)‐HIV co‐infection with high prevalence of tenofovir‐based antiretroviral therapy use
Authors: Gizaw Andinet , King Wendy C. , Hinerman Amanda S. , Chung Raymond T. , Lisker‐Melman Mauricio , Ghany Marc G. , Khalili Mandana , Jain Mamta K. , Graham Jacob , Swift‐Scanlan Theresa , Kleiner David E. , Sulkowski Mark , Wong David K. , Sterling Richard K. ,   The HIV‐HBV Cohort Study of the Hepatitis B Research Network
Published: May 2022

AbstractObjectiveTenofovir disoproxil fumarate (TDF) is a common component of antiretroviral therapy in hepatitis B virus (HBV)‐HIV co‐infected adults but few studies have evaluated worsening renal function and bone turnover, known effects of TDF.MethodsAdults from eight North American sites were enrolled in this cohort study. Research assessments were conducted at entry and every 24 weeks for ≤192 weeks. Bone markers were tested at baseline, week 96 and week 192 from stored serum. We evaluated changes in markers of renal function and bone turnover over time and potential contributing factors.ResultsA total of 115 patients were prospectively followed; median age 49 years, 91% male and 52% non‐Hispanic Black. Duration of HIV was 20.5 years. TDF use ranged from 80% to 92% throughout follow‐up. Estimated glomerular filtration rate (eGFR) (ml/min/1.73m2) decreased from 87.1 to 79.9 over 192 weeks (p < 0.001); however, the prevalence of eGFR <60 ml/min/1.73m2 did not appear to differ over time (always <16%; p = 0.43). From baseline to week 192, procollagen type I N‐terminal propeptide (P1NP) (146.7 to 130.5 ng/ml; p = 0.001), osteocalcin (14.4 to 10.2 ng/ml; p < 0.001) and C‐terminal telopeptides of type I collagen (CTX‐1) (373 to 273 pg/ml; p < 0.001) decreased. Younger age, male sex and overweight/obesity versus normal weight predicted a decrease in eGRF. Black race, healthy weight versus underweight, advanced fibrosis, undetectable HBV DNA, and lower parathyroid hormone level predicted worsening bone turnover.ConclusionIn this HBV‐HIV cohort with high prevalence of TDF use, several biomarkers of renal function and bone turnover indicated worsening status over approximately 4 years, highlighting the importance of clinical awareness in co‐infected adults.
The influence of parental body composition and lifestyle on offspring growth trajectories
Authors: Versele Vickà , Dieberger Anna , van Poppel Mireille , Van De Maele Karolien , Deliens Tom , Aerenhouts Dirk , Clarys Peter , Devlieger Roland , Bogaerts Annick 
Published: May 2022

SummaryBackground and ObjectivesParental body composition, physical activity (PA) and sedentary time (ST) have been linked with offspring body weight and health. However, independent contributions of body composition, PA and ST of both parents on growth trajectories of their offspring, taking into account sex differences, has not been investigated.MethodsA total of 114 mother–father–child triads were included for analyses. Parental weight, height, PA and ST were objectively measured at 12 weeks of gestation. Gestational weight gain (GWG) and birthweight and ‐length were obtained from medical records. Offspring weight and length were measured repeatedly until 1 year of age. Longitudinal linear mixed models, stratified by offspring sex, were used to analyse the association between parental characteristics and offspring growth.ResultsGWG (positive association), maternal moderate‐to‐vigorous PA (negative association) and paternal ST (positive association) were associated with weight trajectories in girls but not in boys. Parental characteristics were not associated with offspring length trajectories.ConclusionsThis study highlights the contribution of parental lifestyle characteristics on weight trajectories of their daughters during the first year of life. The paternal impact stresses the need to further investigate health behaviours of expecting fathers in relation to offspring health. Family‐based interventions are needed with a focus on increasing PA and limiting ST in both parents.
Ceriporia lacerata HG2011 enhances P mobilization and wheat agronomic performance irrespective of P fertilization levels
Authors: Sui Zongming , Huang Jianguo , Yuan Ling 
Published: May 2022

Abstract

Aims
To identify soil phosphorus (P) mobilization and wheat agronomic performance in response to the P mobilizer Ceriporia lacerata HG2011 could provide a new strategy for improving fertilizer P efficiency in wheat cultivation.

Methods and Results
Liquid culture showed that C. lacerata HG2011 converted Ca3(PO4)2, FePO4, AlPO4, phytate, lecithin and ribonucleic acid into soluble inorganic P, which was stimulated by ammonium and urea but less influenced by P supply. In the incubation experiment, this fungus colonized on wheat roots, and mobilized P in the soils regardless of Olsen P levels. The efflux of protons, organic acids and phosphatase could be involved in insoluble P mobilization. In the greenhouse pot experiment, C. lacerata HG2011 increased soil Olsen P under different P fertilization levels, improved wheat P uptake by 15.39%–28.70%, P fertilizer use efficiency by 4.26%–13.04% and grain yield by 12.24%–22.39%.

Conclusions
Ceriporia lacerata HG2011 was able to colonize on wheat roots, mobilize P in soils and improve wheat agronomic performance irrespective of P fertilization levels.

Significance and Impact of the Study
Ceriporia lacerata HG2011 could be used to enhance the quality of compost or as a bio-fertilizer for P mobilization in modern sustainable agriculture.
Combination of FOXD1 and Plk2: A novel biomarker for predicting unfavourable prognosis of colorectal cancer
Authors: Zong Yaping , Miao Yiming , Li Wenchang , Zheng Minhua , Xu Zhuoqing , Gao Han , Feng Wenqing , Xu Zifeng , Zhao Jingkun , Shen Lifei , Lu Aiguo 
Published: May 2022

AbstractColorectal cancer (CRC) is a worldwide disease with worse survival. Our objective is to identify previously unrecognized prognostic factors to better evaluate disease progression. Seven GEO datasets were collected and analysed using R software, followed by KEGG enrichment analysis and TFs network construction. LASSO‐COX analysis was performed to select the most useful prognostic features. COX model was used to analyse prognostic factors associated with OS. The survival curve was constructed using Kaplan–Meier analysis. A Nomogram model was also constructed to predict prognosis. A total of 3559 differentially expressed genes (DEGs) and 66 differentially expressed transcription factors were identified. FOXD1 was identified as the most differentially expressed factor of TFs covering the most downstream DEGs and independent risk prognostic factor. Next, FOXD1 expression was detected using immunohistochemical staining in 131 CRC patients’ tissue and the association between FOXD1 expression and clinicopathologic features was analysed. High expression of FOXD1 was correlated with TNM stage and pathological differentiation. Multivariate COX regression analyses confirmed that FOXD1 high‐expression, TNM stage and tumour differentiation were independent prognostic risk factor of OS and DFS. Patients with high expression of FOXD1 were more likely to have poor overall survival and disease‐free survival. The combination of FOXD1 and Plk2 which we have previously reported allowed us to predict the survival of post‐surgical CRC patients more accurately, adding to the former prognostic model based on the TNM Stage. The results showed that patients with high expression of both FOXD1 and Plk2 have the worst survival. A combination of FOXD1 and Plk2 can better evaluate patients’ survival.
Species identification of bacterial communities in the small brown planthopper, Laodelphax striatellus (Hemiptera: Delphacidae)
Authors: Zhao Dian‐Shu , Gao Zi‐Jie , Wang Su‐Dan , Wan Yu‐Ying , Bing Xiao‐Li , Hong Xiao‐Yue 
Published: May 2022

AbstractMicrobes are prevalent and abundant in diverse insects. Many microbes are known to influence host fitness. The small brown planthoppers Laodelphax striatellus Fallen is a notorious plant sap‐feeding pest causing heavy loss to rice yield. Some L. striatellus‐associated microbes have been surveyed partially. However, their microbial communities at the species level were poorly identified. In this study, we investigated the bacterial community from 7 populations of L. striatellus using the restriction fragment length polymorphism (RFLP)‐PCR of the 16S rRNA gene. The identified bacteria were assigned into 8 species, the top three of which (Wolbachia sp., Pseudomonas poae and Asaia sp.) accounted for 96% of amplified bacterial sequences. The Wolbachia is of supergroup B and the most abundant in all wild populations. In addition, P. poae was reported in L. striatellus and showed mild pathogenicity. Altogether, our results provide detailed information on the bacterial community in L. striatellus. More research is required to explore the effects of symbiotic bacteria on the fitness of small brown planthoppers.
Clinical implications of the distinct anatomy and innervation of the long head biceps tendon
Authors: Harte Lauren M. , Rick Taylor , Bisson Leslie J. , Inglis Stuart , Marzo John M. 
Published: May 2022

AbstractThe proximal long head of the biceps tendon (LHBT) has been recognized as a well‐known cause of anterior shoulder pain. Previous studies have identified a heterogeneous distribution of nerve fibers in the tendon, with a higher abundance of fibers in the proximal and distal thirds of the tendon. This suggests that the proximal portion of the long head biceps tendon may have a different source of innervation than the distal portion. The purpose of this study was to review the innervation of the superior shoulder and identify the proximal source of sensory innervation of the LHBT. The relevant hypothesis was that the suprascapular nerve (SSN) was the proximal source of sensory innervation to the LHBT. Gross and microdissection of eight fresh human cadaver shoulders were performed, with a focus on the distal articular branches of suprascapular nerve (SSN). Utilizing 3.5× magnification loupes, the medial subacromial branch (MSAb), lateral subacromial branch (LSAb), and posterior glenohumeral branch (PGHb) were identified and followed distally to their terminal branches. In all specimens, terminal branches of the lateral subacromial branch supplied the proximal LHBT and the superior labrum. Terminal branches of the posterior glenohumeral branch supplied the posterosuperior labrum and, to a lesser extent, the labral attachment of the LHBT. These findings confirm branches of the suprascapular nerve as the proximal source of sensory innervation to the LHBT. Identification of the suprascapular nerve as a source of proximal innervation of the LHBT may influence clinical decisions related to nonsurgical and surgical intervention, nerve blocks, and nerve ablation procedures.
Resettled but not redressed: Land restitution and post‐settlement dynamics in South Africa
Authors: Chitonge Horman 
Published: May 2022

AbstractRedressing the wrongs of the past has been a central theme in democratic South Africa. The land restitution programme was specifically intended to foster the process of redressing the loss and pain inflicted through racially motivated and violent dispossession of land. After more than two and half decades of implementing the land restitution programme, there are serious questions around how far this programme has contributed to redressing the injustices of the past. This paper, drawing from three land restitution case studies, illustrates that while many victims of colonial and apartheid land dispossession have been compensated, the land restitution process has scored limited success in redressing past injustices. The paper argues that the failure to substantively redress colonial and apartheid land dispossession is partly due to the narrow conceptualization of the restitution programme, which has emphasized procedural aspects, ignoring the need for meaningful redress of the victims of land dispossession. As a result of this, the land restitution programme has not fulfilled its transformative objectives of reconciliation, reconstruction, and reducing land inequalities in the country.
Intersectionality and nursing leadership: An integrative review
Authors: Aspinall Cathleen , Jacobs Stephen , Frey Rosemary 
Published: May 2022

AbstractAims and objectivesThis review aimed to synthesise international research about how intersectionality has been used to explore issues within the nursing profession. The objectives were to determine which intersecting variables have been explored, how intersectionality has been operationalised, and the implications for nursing leadership.BackgroundBarriers to health system leadership created at the intersection of gender, race, ethnicity, professional cadre and other socially constructed categories exist in the health workforce. Consequently, an intersectionality paradigm has been recommended to explore power, privilege and oppression issues in the nursing profession.DesignAn integrative systematic review method was selected for its ability to include diverse methodologies. The review complies with the PRISMA guidelines for reporting systematic reviews.MethodThe search terms nurs* nurses nursing AND Intersectionality intersectional intersectionalism, intersect were used in December 2021 to search the Cumulative Index to Nursing and Allied Health Literature (CINAHL Plus) PsycINFO, PubMed, Ovid, ProQuest and the first ten pages of Google Scholar from 2011 to 2021. Directed content analysis was applied to the data.ResultsAccess to education, absence of expectations as a career and patriarchal structures support male nurses into positions of leadership in healthcare systems. Intra‐group differences highlight the paradox of homogenous categories for ethnicity and gender. Being a member of an ethnic minority group hinders career progression regardless of gender. The aftereffects of colonisation exist within the nursing space.ConclusionsThis review is the first to synthesise research using intersectionality to explore the impact of socially constructed identities on nursing leadership. There is a dearth of evidence specific to this topic, ignoring the diversity within this professional group. Future research should include intersectionality to discover how social categories empower or impede a nurse's career progression to leadership roles.Relevance to clinical practiceAn intersectionality paradigm can encourage nurses to attend to issues of power, privilege and oppression in the profession and their practice.
Understanding the Needs of Primary School Teachers in Supporting Their Students' Emotion Regulation
Authors: Petrovic Julia , Mettler Jessica , Argento Amanda , Carsley Dana , Bloom Elana , Sullivan Shaun , Heath Nancy L. 
Published: May 2022

ABSTRACTBackgroundAccumulating evidence has underscored the importance of fostering children's emotion regulation (ER) within primary school settings and the role of teachers in such efforts. This study sought to assess the needs of teachers in supporting students' ER, through a better understanding of teachers' perceptions and use of healthy versus unhealthy ER strategies in the classroom.MethodsPrimary school teachers (n = 212; 91% female) completed an online, researcher‐developed needs assessment survey assessing their perceptions regarding the importance of ER instruction and challenges surrounding children's ER, as well as the perceived effectiveness and reported use of healthy and unhealthy ER strategies in the classroom.ResultsCochran's Q and chi‐square analyses revealed misperceptions regarding the effectiveness of healthy and unhealthy strategies, as well as discrepancies between teachers' perceptions regarding the effectiveness of specific healthy strategies (eg, meditation) and their reported use of them.ConclusionsWhile teachers recognize the growing importance of fostering ER in the classroom, the present findings suggest that there is a need for more professional development regarding the effectiveness and implementation of ER strategies in the primary school context. Efforts should be made to provide teachers with concrete recommendations for the implementation of ER strategies in the classroom.
Winners and losers of the COVID‐19 pandemic: An excess profits tax proposal
Authors: Azémar Céline , Desbordes Rodolphe , Melindi‐Ghidi Paolo , Nicolaï Jean‐Philippe 
Published: May 2022

AbstractIn this paper, we study the gains and losses incurred during the COVID‐19 pandemic. We distinguish between the effects of the pandemic and those of the health measures implemented to reduce the death toll, notably “the lockdown.” Our theoretical model is focused on within‐sector firm heterogeneity and involves imperfect competition in a partial equilibrium setting. A comparison between the gains and losses triggered by both the pandemic and the lockdown indicates that an excess profits tax imposed on the “winners” could partly compensate the “losers” of the same sector.