bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving mechanical and thermal properties of short carbon fiber/polyamide 6 composites through a polydopamine/nano‐silica interface layer
Authors: Li Bowen , Song Guojun , Peng Zhi , Zhang Wenjian , Zheng Hao , Zhu Junjie , Wang Chaohang , Wang Jianfa , Ma Ruiyue , Zhu Shaoqian , Yang Xiaoping , Huang Yudong , Ma Lichun 
Published: November 2022

AbstractCarbon fiber (CF) reinforced matrix composites have been applied widely, however, the interfacial adhesion of composites is weak due to smooth and chemically inert of CF surface. To solve this problem, A polydopamine/nano‐silica (PDA‐SiO2) interfacial layer on carbon fiber surface was constructed via polydopamine and nano‐ SiO2 (CF‐PDA‐SiO2) by a facile and effective method to reinforce polyamide 6 composites (CFs/PA6). The effects of PDA‐SiO2 interfacial layer on crystallization structure and behavior, thermal properties, and mechanical properties of CFs/PA6 composites were investigated. Furthermore, interfacial reinforcement mechanism of composites has been discussed. This interfacial layer greatly increased the number of active groups of CF surface and its wettability obviously. The tensile strength of CF‐PDA‐SiO2/PA6 composites increased by 28.09%, 19.37%, and 26.22% compared to untreated‐CF/PA6, CF‐PDA/PA6, and CF‐SiO2/PA6 composites, respectively, which might be caused by the increased interfacial adhesion between CF and PA6 matrix. The thermal stability, crystallization temperature, crystallinity, and glass transition temperature (Tg) of CF‐PDA‐SiO2/PA6 composites improved correspondingly, attributing to the heterogeneous nucleation of nano‐SiO2 in the crystalline area and hydrogen bonds with molecular chains of PA6 in the amorphous area. This work provides a novel strategy for the construction of interfaces suitable for advanced CF composites with different structures.
Interface Engineering and Device Applications of 2D Ultrathin Film/Ferroelectric Copolymer P(VDF‐TrFE)
Authors: Dang Zhaoying , Guo Feng , Wu Zehan , Jin Kui , Hao Jianhua 
Published: November 2022

AbstractFerroelectric materials with switchable electrical polarization have been widely used in tunnel junctions, non‐volatile memories, and field‐effect transistors. Large‐area organic ferroelectric polymers compatible with silicon or flexible substrates have played a crucial role in nanoelectronics. Poly(vinylidene fluoride‐trifluoroethylene) P(VDF‐TrFE) as a representative, different from traditional bulk oxide ferroelectrics in terms of atom arrangements and fabrication methods, has frequently been used as the ferroelectric gate for high‐performance electronic, optical, and synaptic transistors. Ferroelectric copolymers have gradually become a promising and versatile alternative for inorganic ferroelectrics. This review will focus on the interface engineering and device applications of 2D materials/ferroelectric P(VDF‐TrFE) hybrid structures. The intrinsic ferroelectric properties and unique features of P(VDF‐TrFE) are first elucidated. Next, typical device structures with ferroelectric gating effect followed by its physical working mechanisms will be discussed. In the next section, diverse nanoelectronics applications of ferroelectric field effect transistors based on P(VDF‐TrFE), including optoelectronic devices, non‐volatile memories, neuromorphic computing, and negative capacitance transistors, are clarified. Moreover, existing challenges and further development for ferroelectric polymer will be discussed. With an emphasis on the ferroelectric polymer gate and related issues, this review provides a timely summary of current physical understanding and progresses.
Rapid production of multimeric RNA aptamers stabilized by a designed pseudo‐circular structure in E. coli
Authors: Zou Zongsheng , Younas Tayyaba , Dumsday Geoff , Haritos Victoria S. , He Lizhong 
Published: November 2022

AbstractRNA aptamers bind specifically and selectively to various macromolecules, cell surfaces, and viruses and find broad applications as biosensors, diagnostics, and in therapeutic treatments and drug delivery. Currently, RNA aptamer production is via in vitro methods. Herein, a new E. coli‐based approach has been demonstrated for the rapid production of multimeric RNA aptamer transcripts that are protected from degradation by burying the 5′ and 3′ ends of the transcript in a designed double‐stranded spacer. Multimeric and fluorescent RNA aptamers were produced stably in vivo and readily isolated from RNase III‐deficient cells, and their full functionalities were shown by binding assays and fluorescence measurements. This approach shows promise as a rapid and scalable bioprocess for the production of RNA aptamers at low cost.
Cocktail drug usage and etofenamate detection in post‐race equine urine sample: A case report
Authors: Kabil Erol , Göktaş Eylem Funda , Güneş Ertuğrul , Yatanaslan Levent , Zor Tuba Asena , Tektaş Muhammet Hakan , İnceman Bahadır , Tufan Murat 
Published: November 2022

AbstractA recent trend in the use of high‐resolution accurate mass screening (HRAMS) for doping control testing in both human and animal sports has emerged owing to significant improvement in high‐resolution mass spectrometry in terms of sensitivity, mass accuracy, mass resolution and mass stability. Several HRAMS methods have been reported for the detection of multidrug residues in human or equine urine. These improved analytical technologies have led to changes in the use of prohibited substances, and the administration of more than one substance at low concentrations as a “cocktail” has become one of the methods used to alter performance in racehorses. In one of horse urine samples transferred to the analytical laboratory in Turkey for analysis, 5‐hydroxymethyl meloxicam (2.96 ng/ml), etofenamate (2.15 ng/ml), flufenamic acid (108.92 ng/ml) and cobalt (200 ng/ml) were detected. These findings reveal that more than one prohibited substance was used together as a cocktail to alter the racing performance at low doses. In this case report, flufenamic acid was detected as a metabolite of etofenamate along with the parent drug. This case study also supports the advantages of metabolite analysis for anti‐doping laboratories.
Relationship between depression, anxiety, and perceived stress in health professionals and their perceptions about the quality of the health services in the context of COVID‐19 pandemic
Authors: Olórtegui‐Yzú Adriel , Vega‐Dienstmaier Johann M. , Fernández‐Arana Alberto 
Published: November 2022

AbstractBackgroundThe health emergency caused by COVID‐19 revealed the shortcomings of health services (HS), but little is known about how this has impacted the mental health of health professionals (HP).MethodsData were collected through an online survey administered to HP in Lima (Peru) between May and July 2020. Instruments were applied to evaluate anxiety, depression, perceived stress (PS), and perceived quality of health services (PQHS).ResultsA total of 507 HP completed the survey. In the multivariate analysis, younger age and female gender were related to anxiety, depression, and PS (all with p < .001). The most relevant unfavorable PQHS associated with anxiety were competence of other HP to care for HP if infected (p = .002) and support for HP or their families in the event of becoming infected (p = .001); the most relevant unfavorable PHQS associated with depression were equipment to care for HP and their families if infected (p = .003); support for HP or their families if infected (p < .001); fear of HP and/or family members being infected or dying (p = .006); and HP’ recognition of their competencies (p < .001); and the most relevant unfavorable PHQS associated with PS were support for HP or their families if infected (p < .001) and instability of knowledge (p = .027).ConclusionsThere was an association between impaired mental health and PQHS scores among HP. This study shows the need for HP to express their concerns about how HS are supporting their safety and that of their family during health emergencies.
A true response of the brain network during electroacupuncture stimulation at scalp acupoints: An fMRI with simultaneous EAS study
Authors: Chen Hui , Jann Kay , Li Yijing , Huang Jiling , Chen Yilei , Kang Yingjie , Gong Zhigang , Huang Yanwen , Wang Hui , Zhan Songhua , Tan Wenli 
Published: November 2022

AbstractObjectivesThe aim of this study was to explore simultaneous brain network responses to electroacupuncture stimulation (EAS) at scalp acupoints by accounting for placebo effects.Materials and MethodsSixty healthy subjects were recruited and randomly divided into two groups: Group 1 and Group 2. Functional magnetic resonance imaging (fMRI) was performed in Group 1 with sham acupuncture stimulation at acupoints Shenting (GV24) and Touwei (ST8) without EAS. Group 2 underwent verum EAS at the same acupoints during fMRI. Independent component analysis was used to analyze the fMRI data. Full‐factor statistical analysis was used to compare the differences in fMRI data between the two groups and evaluate the changes in functional connectivity in brain networks after verum electrical stimulation (Group 1 [after sham electrical current stimulation − before sham electrical current stimulation] − Group 2 [after verum electrical current stimulation − before verum electrical current stimulation]) (p <.001, extent threshold k = 20 voxels).ResultsSix brain networks were identified. Significant increased functional connectivity was observed in the right and left executive control networks, sensorimotor network, and attention network, while decreased functional connectivity was mainly found in the default mode network. There were no statistically significant differences in the salience network.ConclusionsfMRI with simultaneous EAS provides a method to explore brain network responses due to EAS at scalp acupoints. The networks responsible for cognition are differentially activated by EAS in a coordinated manner.
A multicenter study of clinical impact of variant of uncertain significance reclassification in breast, ovarian and colorectal cancer susceptibility genes
Authors: Makhnoon Sukh , Levin Brooke , Ensinger Megan , Mattie Kristin , Volk Robert J. , Zhao Zhongming , Mendoza Tito , Shete Sanjay , Samiian Laila , Grana Generosa , Grainger Andrew , Arun Banu , Shirts Brian H. , Peterson Susan K. 
Published: November 2022

AbstractBackgroundClinical interpretation of genetic test results is complicated by variants of uncertain significance (VUS) that have an unknown impact on health but can be clarified through reclassification. There is little empirical evidence regarding VUS reclassification in oncology care settings, including the prevalence and outcomes of reclassification, and racial/ethnic differences.MethodsThis was a retrospective analysis of persons with and without a personal history of cancer carrying VUS (with or without an accompanying pathogenic or likely pathogenic [P/LP] variant) in breast, ovarian, and colorectal cancer predisposition genes seen at four cancer care settings (in Texas, Florida, Ohio, and New Jersey) between 2013 and 2019.ResultsIn 2715 individuals included in the study, 3261 VUS and 313 P/LP variants were reported; 8.1% of all individuals with VUS experienced reclassifications and rates varied significantly among cancer care settings from 4.81% to 20.19% (overall p < 0.001). Compared to their prevalence in the overall sample, reclassification rates for Black individuals were higher (13.6% vs. 19.0%), whereas the rates for Asian individuals were lower (6.3% vs. 3.5%) and rates for White and Hispanic individuals were proportional. Two‐year prevalence of VUS reclassification remained steady between 2014 and 2019. Overall, 11.3% of all reclassified VUS resulted in clinically actionable findings and 4.6% subsequently changed individuals' clinical managements.ConclusionsThe findings from this large multisite study suggest that VUS reclassification alters clinical management, has implications for precision cancer prevention, and highlights the need for implementing practices and solutions for efficiently returning reinterpreted genetic test results.
Glucose metabolism and lncRNAs in breast cancer: Sworn friend
Authors: Xu Jia‐Lin , Xu Qi , Wang Ya‐Lin , Xu Di , Xu Wen‐Xiu , Zhang He‐Da , Wang Dan‐dan , Tang Jin‐Hai 
Published: November 2022

AbstractBackgroundGlucose metabolism disorder is a common feature in cancer. Cancer cells generate much energy through anaerobic glycolysis, which promote the development of tumors. However, long non‐coding RNA may play an important role in this process. Our aim is to explore a prognostic risk model based on the glucose metabolism‐related lncRNAs which provides clues that lncRNAs predict a clinical outcome through glucose metabolism in breast cancer.Methods1222 RNA‐seq were extracted from the TCGA database, and 74 glucose metabolism‐related genes were loaded from the GSEA website. Then, 7 glucose metabolism‐related lncRNAs risk score model was developed by univariate, Lasso, and multivariate regression analysis. The lncRNA risk model showed that high‐risk patients predict a poor clinical outcome with high reliability (P=2.838×10‐6). Univariate and multivariate independent prognostic analysis and ROC curve analysis proved that the risk score was an independent prognostic factor in breast cancer with an AUC value of 0.652. Finally, Gene set enrichment analysis showed that cell cycle‐related pathways were significantly enriched in a high‐risk group.ResultsOur results showed that glucose metabolism‐related lncRNAs can affect breast cancer progression. 7 glucose metabolism‐related lncRNAs prognostic signature was established to evaluate the OS of patients with breast cancer. PICSAR, LINC00839, AP001505.1, LINC00393 were risk factors and expressed highly in the high‐risk group. A Nomogram was made based on this signature to judge patients' living conditions and prognosis.Conclusion7 glucose metabolism‐related lncRNAs risk score model had a high prognostic value in breast cancer. PICSAR, LINC00839, AP001505.1, LINC00393 were risk factors. AP001505.1 expression was increased in most triple‐negative breast cancer cells treated with high glucose, which may also take part in breast cancer progression and potential therapeutic targets
Arrhythmic events associated with immune checkpoint inhibitors therapy: A real‐world study based on the Food and Drug Administration Adverse Event Reporting System database
Authors: Liu Yunwei , Chen Yanxin , Zeng Zhimin , Liu Anwen 
Published: November 2022

AbstractBackgroundAlthough arrhythmias have been reported in patients treated with immune checkpoint inhibitors (ICIs), the association between arrhythmias and ICIs has not been thoroughly evaluated in real‐world studies. We aimed to describe the major features of ICI‐related arrhythmic events and identify the factors that contributed to death.MethodsA disproportionality analysis was performed using data from the Food and Drug Administration Adverse Event Reporting System (FAERS) database from January 2011 to December 2021. Reporting odds ratios (RORs), proportional reporting ratio and information component were used to assess whether adverse arrhythmic events were associated with ICIs. The clinical characteristics of patients with ICI‐associated arrhythmias were compared with fatal and non‐fatal arrhythmias. The time to onset (TTO), fatality rates of arrhythmic events were also investigated.ResultsWe identified a total of 1945 cases of ICI‐related arrhythmic events. Men (64.78%) were identified significantly more frequently than women (28.84%). The median age was 68 years ([interquartile range, IQR] 60–75 years). Anti‐programmed cell death‐1 (PD‐1) and anti‐programmed cell death ligand‐1 (PD‐L1) were associated with adverse arrhythmic events, corresponding to ROR 1.11 (95% confidence interval [CI] 1.05–1.17) and ROR 1.34 (95% CI 1.20–1.49), respectively. However, anti‐cytotoxic T‐lymphocyte associated protein 4 or combination immunotherapy did not appear to be associated with arrhythmic events. Atrial fibrillation (N = 576, 0.62%), cardiac arrest (N = 284, 0.31%), tachycardia (N = 175, 0.19%) were the most common adverse arrhythmic events. Sudden death and complete atrioventricular block are adverse events that are significantly associated with ICI‐related arrhythmic events and have strong signal intensity. The TTO of cases that resulted in death (30 days [IQR] 11–73.75) was significantly earlier than that of cases that did not result in death (33 days [IQR 10.5–88.5], p = 0.003). ICI‐related arrhythmic events were severe with death occurring in 507 (26.07%) of 1945 arrhythmias cases.ConclusionsTreatment with PD‐1/PD‐L1 may cause arrhythmic events, which are severe and tend to occur early on during treatment. It is important to identify ICI‐related arrhythmias as early as possible, and to manage them appropriately.
Gliclazide Removal Efficiency of Carbon‐Based Magnetic Materials: Isotherm and Kinetic Studies
Authors: Çavuşoğlu Ferda Civan 
Published: November 2022

AbstractGliclazide, one of the micropollutants that can be detected in water, is widely used in the treatment of type II diabetes patients. In this study, the removal of gliclazide from aqueous solutions with magnetic carbon‐based materials was investigated. Magnetic activated carbon (MAC) and magnetic multiwalled carbon nanotube (MMWCNT) adsorbents were prepared and characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X‐ray diffraction, and thermogravimetric analysis methods. The effects of various parameters affecting the adsorption process were examined. The adsorption systems were compatible with the Langmuir isotherm model and the pseudo‐second‐order kinetic model. The maximum monolayer adsorption capacities of the MAC adsorbent (298 K) and the MMWCNT (308 K) were 109.20 and 71.59 mg g−1, respectively. According to desorption studies, adsorbents could be regenerated by around 70 % in 6 hours.
Separation of Diclofenac Sodium Using Polysulfone Membranes Incorporated with Manganese Nanoparticles
Authors: Abdallah Heba , Gaballah Soha , Mansour Moustapha Salem , Farag Hassan , Farid Yousra Hamdy 
Published: November 2022

AbstractMembranes are employed in various applications, including pharmaceutical waste separation, owing to their operability, high removal capacity, and cost‐effectiveness. However, membrane fouling is an influential factor that reduces their efficiency. Since the addition of hydrophilic inorganic components has been shown to reduce membrane fouling, the present work focuses on manganese (MnO2, Mn2O3) nanoparticles (NP) in polysulfone (PSF) casting solutions to prepare mixed‐matrix membranes for separating diclofenac (DCF) sodium from an aqueous solution. The membranes were characterized using microscopic and spectroscopic techniques, thermogravimetric analysis, and by elucidating the internal membrane specific area, contact angle, and mechanical properties. The synthesized NP were characterized by X‐ray diffraction and transmission electron microscopy analysis. The concentrations of DCF sodium measured in the feed and filtrate solutions showed that the PSF/Mn2O3 membrane provided the highest permeate flux with good DCF removal of 98.4 %. Mechanical testing indicated that higher tensile strength was obtained when embedding MnO2 NP in the PSF membrane matrix. Contact angle measurements showed an improvement of the surface hydrophilicity when blending the PSF casting solution with MnO2 NP. The fouling test indicated that the PSF/Mn2O3 membrane provided the best antifouling properties. Thus, NP addition enhanced the porosity, antifouling characteristics, hydrophilicity, and water flux of the fabricated membranes.
Age differences in the association between sleep and Alzheimer's disease biomarkers in the EPAD cohort
Authors: Naismith Sharon L. , Leng Yue , Palmer Jake R. , Lucey Brendan P. 
Published: November 2022

AbstractIntroductionWe aimed to determine the independent association between sleep quality and Alzheimer's disease (AD) biomarkers, and whether the associations differ with age.MethodsWe included 1240 individuals aged ≥50, without dementia from the European Prevention of Alzheimer's Disease v1500.0 dataset. Linear regression was used to examine Pittsburgh Sleep Quality Index (PSQI) scores against cerebrospinal fluid (CSF) phosphorylated tau/β‐amyloid ratio (p‐tau/Aβ42) for the entire sample and via age tertiles. Models controlled for demographic, clinical, genetic, vascular, and neuroimaging variables.ResultsFor the youngest age tertile, shorter sleep duration and higher sleep efficiency were associated with greater p‐tau/Aβ42 ratio. For the oldest tertile, longer sleep latency was associated with greater p‐tau/Aβ42.DiscussionDifferential relationships between sleep and AD pathology depend on age. Short sleep duration and sleep efficiency are relevant in middle age whereas time taken to fall asleep is more closely linked to AD biomarkers in later life.Highlights
This study shows age differences in the link between sleep and AD biomarkers.
Shorter sleep was associated with greater p‐tau/Aβ42 ratio in middle age.
The association was independent of genetic, vascular, and neuroimaging markers of AD.
Inflammasome activation and CCR2‐mediated monocyte‐derived dendritic cell recruitment restrict Legionella pneumophila infection
Authors: Ataide Marco A. , Manin Graziele Z. , Oliveira Samuel S. , Guerra Rhanoica O. , Zamboni Dario S. 
Published: November 2022

AbstractFlagellin‐induced NAIP/NLRC4 inflammasome activation and pyroptosis are critical events restricting Legionella pneumophila infection. However, the cellular and molecular dynamics of the in vivo responses against this bacterium are still unclear. We have found temporal coordination of two independent innate immunity pathways in controlling Legionella infection, the inflammasome activation and the CCR2‐mediated Mo‐DC recruitment. Inflammasome activation was an important player at the early stage of infection by lowering the numbers of bacteria for an efficient bacterial clearance conferred by the Mo‐DC at the late stage of the infection. Mo‐DC emergence highly depended on CCR2‐signaling and dispensed inflammasome activation and pyroptosis. Also, Mo‐DC compartment did not rely on the inflammasome machinery to deliver proper immune responses and was the most abundant cytokine‐producing among the monocyte‐derived cells in the infected lung. Importantly, when the CCR2‐ and NLRC4‐dependent axes of response were simultaneously ablated, we observed an aggravated bacterial burden in the lung of infected mice. Taken together, we showed that inflammasome activation and CCR2‐mediated immune response interplay in distinct pathways to restrict pulmonary bacterial infection. These findings extend our understanding of the in vivo integration and cooperation of different innate immunity arms in controlling infectious agents.