bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing Engagement of Adolescents and Young Adults (AYA) in HIV Research: A Multi-method Analysis of a Crowdsourcing Open Call and Typology of AYA Engagement in Sub-Saharan Africa
Authors: Tahlil Kadija M. , Rachal Laura , Gbajabiamila Titi , Nwaozuru Ucheoma , Obiezu-Umeh Chisom , Hlatshwako Takhona , Tembo Mandikudza , Willis Nicola , Nyagog Carine Oum , Vorkoper Susan , Sturke Rachel , Rosenberg Nora E. , Ojo Victor , Moses Isaac , Ahmed Nadia , Beima-Sofie Kristin , Roberts Sarah T. , Kateera Brenda , Namisoke-Magongo Eleanor , Mbizvo Michael T. , Iwelunmor Juliet , Ezechi Oliver , Tucker Joseph D. 
Published: July 2022

AbstractEngagement of adolescents and young adults (AYA) in HIV research is increasing in many settings. We organized a crowdsourcing open call to solicit examples of how AYA have been engaged in HIV research in Africa and to develop an engagement typology. We formed a steering committee, promoted the open call, organized judging and recognized finalists. We used a multi-methods approach to identify emerging themes and measure engagement. We received 95 entries from individuals in 15 countries; 74 met the eligibility criteria. More than three-quarters of entries were from AYA (55/74, 74%). Four themes characterized AYA engagement: (1) AYA were co-creators in the HIV research process. (2) AYA were involved in community-level capacity building. (3) AYA were co-leaders in minor risk research. (4) AYA used digital methods to enhance engagement. Our open call identified diverse methods of AYA engagement, which can enhance strategies used to reach AYA in African HIV studies.
How Adolescent Mothers Interpret and Prioritize Evidence About Perinatal Child Protection Involvement: Participatory Contextualization of Published Evidence
Authors: Dion Anna , Nakajima Amy , McGee Amy , Andersson Neil 
Published: July 2022

AbstractPregnant and parenting adolescents are more likely than adults to live with economic and social vulnerability, contributing to a higher risk of poorer maternal and newborn health outcomes. These same factors contribute to higher rates of postpartum child protection investigations among adolescents. This study describes an innovative approach to contextualize evidence on factors contributing to perinatal child protection involvement in the perspectives of pregnant and parenting adolescents. Using Weight of Evidence, an evidence-based participatory procedure, we conducted a conventional literature review and used fuzzy cognitive maps to contextualize evidence in the experiences of young mothers exposed to child protection investigations. Published evidence was contextualized through semi-structured mapping interviews with ten pregnant and parenting youth and subsequently shared with three child protection workers specialized in pre- and post-natal risk assessment. We developed and consolidated explanatory accounts describing how factors contribute to child protection involvement in the perinatal period among adolescent parents. We collaboratively designed and prioritized interventions strategies together with six adolescent parents. Young women highlighted mental health consequences of child protection involvement, including a reluctance to disclose their own health and social needs, challenges to their identity and self-confidence as parents, and social isolation. Women prioritized reducing the stigma they experience in accessing services, strengthening supportive relationships and greater understanding of their rights in child protection investigations as actionable intervention areas. Inputs of young women and service providers precipitated a reconceptualization of risk and identified how to support greater agency and self-determination among young parents experiencing child protection investigations.
The Effects of International Trade on Structural Convergence and CO2 Emissions
Authors: Hübler Michael , Bukin Eduard , Xi Yuting 
Published: July 2022

AbstractThis article introduces a new econometric model that includes an innovative measure of intersectoral structural change. This model describes the structural convergence (or divergence) of sector share patterns across countries (from the North-South or global perspective) influenced by international trade. The econometric analysis applies panel data estimators with different types of fixed effects to the 2013 and 2016 releases of the World Input-Output Database, covering the periods 1995–2009 and 2000–2014. The results show that international trade mostly promotes structural convergence, which is enhanced by sectoral capital intensities. It seems, however, that in this millennium, structural divergence, also fostered by international trade, occurred in terms of the CO$$_2$$

2

intensity of production.
Letting the body find its way: skills, expertise, and Bodily Reflection
Authors: FOULTIER Anna Petronella 
Published: July 2022

AbstractWhat forms of consciousness can the subject have of her body in action? This is a recurrent issue in contemporary research on skilled movement and expertise, and according to a widespread view, the body makes itself inconspicuous in performance in favour of the object or goal that the activity is directed to. However, this attitude to consciousness in bodily performance seems unsatisfying for an understanding of skilled action, and the work of several researchers can be seen as responding to this view: Montero, Legrand, Ravn and others in the philosophy of expertise and of dance have developed various notions of consciousness and cognition to account for the mindful processes at play in performance.Two related questions can be distinguished here: (1) Is there an inherent conflict between skilled action and at least more than marginal awareness of that action, or is it possible – and even desirable – to reflect on our own performance without considerably impeding on it? (2) What forms of consciousness pertaining to the body in action must we distinguish in order to answer the first question?This paper gives an overview of this discussion, focusing on the second issue, although the first will come into play in so far as it is linked with the latter question. Drawing on Merleau-Ponty’s analyses of bodily reflection and on dancers’ descriptions, I show that there is, in phenomenological terms, a bodily level of reflection: a fully conscious and exploratory activity that is led by the skilled body, and that is explicitly aimed at by many performers.
Proof-of-concept of polymetallic phyto-extraction of base metal mine tailings from Queensland, Australia
Authors: Nkrumah Philip Nti , Corzo Remigio Amelia , van der Ent Antony 
Published: July 2022

Abstract
Purpose
The increasing volumes of mine tailings that are being generated globally because of the rise in metal demand, whilst ore-grades continue to decline, call for novel sustainable management options. Phytoextraction using hyperaccumulator plant species may be one of such strategies to deal with these large volumes of contaminated materials. However, base metals (such as zinc, lead, copper) mine tailings are inherently polymetallic that necessitate targeting multiple metal(loid)s simultaneously for effective phytoextraction. The aim of this study was to conduct a proof-of-concept experiment for polymetallic phytoextraction of base metal mine tailings.

Methods
Selected hyperaccumulator plants (Noccaea caerulescens targeting zinc, Biscutella laevigata and Silene latifolia targeting thallium, Phytolacca octandra targeting manganese, Pityrogramma calomelanos targeting arsenic) were grown in monocultures and mixed cultures for 12 weeks on tailings from the zinc-lead-copper Dugald River and Mt Isa Mines, Queensland, Australia.

Results
Noccaea caerulescens accumulated zinc and manganese (up to ~ 1 wt% and ~ 1.4 wt%, respectively) with zinc-manganese co-localization at the leaf apex and margins. The monocultured B. laevigata exhibited severe toxicity symptoms, which were alleviated when co-cultured with N. caerulescens. Trichomes were important storage sites for zinc and manganese in B. laevigata. Silene latifolia accumulated higher thallium than B. laevigata, whilst P. octandra promoted thallium accumulation in S. latifolia.

Conclusions
This proof-of-concept test of polymetallic phytoextraction provides a real-life demonstration of this innovative technology which could be adapted to further experiments at base metal mines around the world.
Textile Dye Removal by Acacia dealbata Link. Pollen Adsorption Combined with UV-A/NTA/Fenton Process
Authors: Teixeira Ana R. , Jorge Nuno , Fernandes José R. , Lucas Marco S. , Peres José A. 
Published: July 2022

AbstractThe decolourization of an aqueous solution of the textile dye Acid Red 88 (AR88) and the control of the invasive plant species Acacia dealbata Link. (ADL) were addressed in this work. The aims of the study were (1) characterization of the ADL pollen, (2) application of the pollen powder in adsorption processes, (3) selection of the best operational conditions for nitriloacetic acid (NTA)-UV-A-Fenton process and (4) assess the efficiency of the combined treatment adsorption and NTA-UV-A-Fenton in AR88 decolourization. In a first step, ADL pollen was used as a AR88 bioadsorbent. Fourier-transform infrared spectroscopy (FTIR) analysis were performed and revealed the presence of proteins, fatty acids, carbohydrates and lignin in the pollen. Afterwards, trough scanning electron microscopy (SEM), it was possible to verify that ADL pollen has several empty spaces that can be used for dye adsorption. Biosorption results showed higher adsorption of AR88 with application of pH 3.0 and [pollen] = 3.0 g/L with 18.8 mg/g of dye adsorbed. The best fitting was observed with Langmuir, SIPS and Jovanovic isotherms (0.993, 0.996 and 0.994, respectively). To complement the biosorption, a UV-A-Fenton process was applied, and results showed a higher AR88 removal with (NTA) addition. Higher irradiance power favored the oxidation process with high Ф photodegradation value and low Electric Energy per Order ($$E_{\text{EO}}$$

E
EO

) and Specific Applied Energy ($$E_{\text{SAE}}$$

E
SAE

). The combination of biosorption with NTA-UV-A-Fenton was the most efficient system with an AR88 decolourization of 98.5% and a total organic carbon (TOC) removal of 83.5%.
Graphical Abstract
Regularized Variational Estimation for Exploratory Item Factor Analysis
Authors: Cho April E. , Xiao Jiaying , Wang Chun , Xu Gongjun 
Published: July 2022

Item factor analysis (IFA), also known as Multidimensional Item Response Theory (MIRT), is a general framework for specifying the functional relationship between respondents’ multiple latent traits and their responses to assessment items. The key element in MIRT is the relationship between the items and the latent traits, so-called item factor loading structure. The correct specification of this loading structure is crucial for accurate calibration of item parameters and recovery of individual latent traits. This paper proposes a regularized Gaussian Variational Expectation Maximization (GVEM) algorithm to efficiently infer item factor loading structure directly from data. The main idea is to impose an adaptive L1\documentclass[12pt]{minimal}
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\begin{document}$$L_1$$\end{document}-type penalty to the variational lower bound of the likelihood to shrink certain loadings to 0. This new algorithm takes advantage of the computational efficiency of GVEM algorithm and is suitable for high-dimensional MIRT applications. Simulation studies show that the proposed method accurately recovers the loading structure and is computationally efficient. The new method is also illustrated using the National Education Longitudinal Study of 1988 (NELS:88) mathematics and science assessment data.
“Image to patient” equal-resolution surface registration supported by a surface scanner: analysis of algorithm efficiency for computer-aided surgery
Authors: Świątek-Najwer Ewelina , Majak Marcin , Popek Michał , Żuk Magdalena 
Published: July 2022

Abstract
Purpose
The “image to patient” registration procedure is crucial for the accuracy of surgical instrument tracking relative to the medical image while computer-aided surgery. The main aim of this work was to create an equal-resolution surface registration algorithm (ERSR) and analyze its efficiency.

Methods
The ERSR algorithm provides two datasets with equal, high resolution and approximately corresponding points. The registered sets are obtained by projection of a user-designed rectangle(s)-shaped uniform clouds of points on DICOM and surface scanner datasets. The tests of the algorithm were performed on a phantom with titanium microscrews. We analyzed the influence of DICOM resolution on the effect of the ERSR algorithm and compared the ERSR to standard paired-points landmark transform registration. The methods of analysis were Target Registration Error, distance maps, and their histogram evaluation.

Results
The mean TRE in case of ERSR equaled 0.8 ± 0.3 mm (resolution A), 0.8 ± 0.5 mm (resolution B), and 1.0 ± 0.7 mm (resolution C). The mean values were at least 0.4 mm lower than in the case of landmark transform registration. The distance maps between the model achieved from the scanner and the CT-based model were analyzed by histogram. The frequency of the first bin in a histogram of the distance map for ERSR was about 0.6 for all three resolutions of DICOM dataset and three times higher than in the case of landmark transform registration. The results were statistically analyzed using the Wilcoxon signed-rank test (alpha = 0.05).

Conclusion
The tests proved a statistically significant higher efficiency of equal resolution surface registration related to the landmark transform algorithm. It was proven that the lower resolution of the CT DICOM dataset did not degrade the efficiency of the ERSR algorithm. We observed a significantly lower response to decreased resolution than in the case of paired-points landmark transform registration.
HIV Testing Uptake According to Opt-In, Opt-Out or Risk-Based Testing Approaches: a Systematic Review and Meta-Analysis
Authors: Soh Qi Rui , Oh Leon Y. J. , Chow Eric P. F. , Johnson Cheryl C. , Jamil Muhammad S. , Ong Jason J. 
Published: July 2022

Abstract
Purpose of Review
Improving HIV testing uptake is essential to ending the HIV pandemic. HIV testing approaches can be opt-in, opt-out or risk-based. This systematic review examines and compares the uptake of HIV testing in opt-in, opt-out and risk-based testing approaches.

Recent Findings
There remain missed opportunities for HIV testing in a variety of settings using different approaches: opt-in (a person actively accepts to be tested for HIV), opt-out (a person is informed that HIV testing is routine/standard of care, and they actively decline if they do not wish to be tested for HIV) or risk-based (using risk-based screening tools to focus testing on certain individuals or sub-populations at greater risk of HIV). It is not clear how the approach could impact HIV test uptake when adjusted for other factors (e.g. rapid testing, country-income level, test setting and population tested).

Summary
We searched four databases for studies reporting on HIV test uptake. In total, 18,238 records were screened, and 150 studies were included in the review. Most studies described an opt-in approach (87 estimates), followed by opt-out (76) and risk-based (19). Opt-out testing was associated with 64.3% test uptake (I2 = 99.9%), opt-in testing with 59.8% (I2 = 99.9%) and risk-based testing with 54.4% (I2 = 99.9%). When adjusted for settings that offered rapid testing, country income level, setting and population tested, opt-out testing had a significantly higher uptake (+ 12% (95% confidence intervals: 3–21), p = 0.007) than opt-in testing. We also found that emergency department patients and hospital outpatients had significantly lower HIV test uptake than other populations.
Long-Term Sequelae of COVID-19 in Experimental Mice
Authors: Paidas Michael J. , Cosio Daniela S. , Ali Saad , Kenyon Norma Sue , Jayakumar Arumugam R. 
Published: July 2022

AbstractWe recently reported acute COVID-19 symptoms, clinical status, weight loss, multi-organ pathological changes, and animal death in a murine hepatitis virus-1 (MHV-1) coronavirus mouse model of COVID-19, which were similar to that observed in humans with COVID-19. We further examined long-term (12 months post-infection) sequelae of COVID-19 in these mice. Congested blood vessels, perivascular cavitation, pericellular halos, vacuolation of neuropils, pyknotic nuclei, acute eosinophilic necrosis, necrotic neurons with fragmented nuclei, and vacuolation were observed in the brain cortex 12 months post-MHV-1 infection. These changes were associated with increased reactive astrocytes and microglia, hyperphosphorylated TDP-43 and tau, and a decrease in synaptic protein synaptophysin-1, suggesting the possible long-term impact of SARS-CoV-2 infection on defective neuronal integrity. The lungs showed severe inflammation, bronchiolar airway wall thickening due to fibrotic remodeling, bronchioles with increased numbers of goblet cells in the epithelial lining, and bronchiole walls with increased numbers of inflammatory cells. Hearts showed severe interstitial edema, vascular congestion and dilation, nucleated red blood cells (RBCs), RBCs infiltrating between degenerative myocardial fibers, inflammatory cells and apoptotic bodies and acute myocyte necrosis, hypertrophy, and fibrosis. Long-term changes in the liver and kidney were less severe than those observed in the acute phase. Noteworthy, the treatment of infected mice with a small molecule synthetic peptide which prevents the binding of spike protein to its respective receptors significantly attenuated disease progression, as well as the pathological changes observed post-long-term infection. Collectively, these findings suggest that COVID-19 may result in long-term, irreversible changes predominantly in the brain, lung, and heart.
TOP2B Is Required to Maintain the Adrenergic Neural Phenotype and for ATRA-Induced Differentiation of SH-SY5Y Neuroblastoma Cells
Authors: Khazeem Mushtaq M. , Casement John W. , Schlossmacher George , Kenneth Niall S. , Sumbung Nielda K. , Chan Janice Yuen Tung , McGow Jade F. , Cowell Ian G. , Austin Caroline A. 
Published: July 2022

AbstractThe neuroblastoma cell line SH-SY5Y is widely used to study retinoic acid (RA)-induced gene expression and differentiation and as a tool to study neurodegenerative disorders. SH-SY5Y cells predominantly exhibit adrenergic neuronal properties, but they can also exist in an epigenetically interconvertible alternative state with more mesenchymal characteristics; as a result, these cells can be used to study gene regulation circuitry controlling neuroblastoma phenotype. Using a combination of pharmacological inhibition and targeted gene inactivation, we have probed the requirement for DNA topoisomerase IIB (TOP2B) in RA-induced gene expression and differentiation and in the balance between adrenergic neuronal versus mesenchymal transcription programmes. We found that expression of many, but not all genes that are rapidly induced by ATRA in SH-SY5Y cells was significantly reduced in the TOP2B null cells; these genes include BCL2, CYP26A1, CRABP2, and NTRK2. Comparing gene expression profiles in wild-type versus TOP2B null cells, we found that long genes and genes expressed at a high level in WT SH-SY5Y cells were disproportionately dependent on TOP2B. Notably, TOP2B null SH-SY5Y cells upregulated mesenchymal markers vimentin (VIM) and fibronectin (FN1) and components of the NOTCH signalling pathway. Enrichment analysis and comparison with the transcription profiles of other neuroblastoma-derived cell lines supported the conclusion that TOP2B is required to fully maintain the adrenergic neural-like transcriptional signature of SH-SY5Y cells and to suppress the alternative mesenchymal epithelial-like epigenetic state.
Identifying the Needs of Primary Care Providers Caring for Breast and Colon Cancer Survivors in the Safety-Net: a Qualitative Study
Authors: Dixit Niharika , Rodriguez Gladys , Sarkar Urmimala , Burke Nancy , Trejo Evelin , Devore Denise Joanna , Couey Paul , Nápoles Anna María 
Published: July 2022

Abstract
As the number of cancer survivors continues to increase and given the shortage of oncology clinicians in safety net health care settings, primary care providers (PCPs) in these settings will increasingly provide cancer survivorship care. In order to ensure equitable care for low-income and underserved breast and colon cancer survivors, it is essential to understand the safety-net PCPs’ perspective. We conducted semi-structured, in-depth qualitative interviews with 11 PCPs working in a safety-net health care system to identify their needs in caring for cancer survivors. Interviews were audio-recorded and professionally transcribed. Two coders independently coded the interviews and conducted regular meetings until we reached consensus on the results. Analysis was based in grounded theory and performed using the constant comparative method. Thematic analysis identified six themes as follows: (1) Cancer survivorship care can be integrated with the whole person and chronic disease care management that occurs in primary care; (2) PCPs’ perceptions regarding patients’ survivorship care needs and their confidence in meeting those needs; (3) preference for a shared care model; (4) coordination of care; (5) PCPs’ need for survivorship care education and training; and (6) unique issues involved in the care of older cancer survivors. PCPs in the safety-net believe that providing comprehensive survivorship care requires coordination of care through the cancer continuum. Tools like checklists, electronic health records-based communication, and convenient electronic consultations with cancer specialists would enhance the quality of survivorship care. Respondents advocate the inclusion of survivorship care education in medical education. The continuity of care with PCPs means that they play a particularly important role in the care of older cancer survivors.