bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changing the administration from within: criticism and compliance by junior bureaucrats in Niger's Refugee Directorate
Authors: Lambert Laura 
Published: July 2022

AbstractResearch has rarely investigated the actions bureaucrats take to challenge the status quo of their organisation from within. Proposing a power-analytical approach to voice, exit and everyday resistance as political strategies of challenging the bureaucratic status quo, I study the difficulties of achieving organisational change in a context of structural constraints on junior bureaucrats’ reformative power. During field research in Niger's Refugee Directorate, I found that despite the associated risks, junior bureaucrats criticised their working conditions and, in confidential conversations, the administration. As precarious staff, they often combined criticism with compliance. In frequent acts of semi-private criticism amongst peers and with external actors, they problematised their working conditions and the state, but performed symbolic conformity in the everyday to avoid sanctions. This strategy nevertheless created autonomy for themselves and mobilised external actors for change-making. In rarer acts of direct criticism voiced to their superiors, the junior staff often complied with the same informal solidarities they vocally criticised.
The Aeolian Environment in Glen Torridon, Gale Crater, Mars
Authors: Sullivan R. , Baker M. , Newman C. , Turner M. , Schieber J. , Weitz C. , Hallet B. , Ellison D. , Minitti M. 
Published: July 2022

AbstractThe Mars Science Laboratory (MSL) rover spent a full martian year exploring the phyllosilicate‐bearing Glen Torridon trough on the flank of Aeolis Mons in Gale crater, enabling in‐depth assessment of aeolian processes. MSL encountered erosional and depositional features recording a long aeolian history. The trough has served as a long‐term conduit for sand transport, probably involving many cycles of sand accumulation and deflation. Rock abrasion textures indicate sand‐driving winds blowing W‐SW (opposite of abrasion textures on the Greenheugh Pediment above the trough floor). Indurated megaripple surfaces with 2–5 mm grains contrast with seasonally active ripples having finer maximum grain sizes, indicating more vigorous saltation in the past. Active ripples display a broad continuum of wavelengths, as well as coarser grains at crests than troughs, consistent with origins as impact ripples. Orientations of a wind streak extending from a large ripple field, and sandy wind tails behind obstacles, indicate sand is driven W‐SW in the current era, approximately along the trough axis. Erosion of drill tailings piles was strongly seasonal, enhanced during late spring and early summer (perihelion). Climate modeling suggests W‐SW sand transport can be attributed to seasonal enhancement of nighttime regional winds entering Gale crater from the N, combined with local katabatic winds flowing down the slopes of Aeolis Mons. However, it is unclear whether sand transport at Glen Torridon is primarily from these wind components combining and acting simultaneously, or occurring in serial at different times of night; field evidence supports both possibilities.
Spatio‐Temporal Level Variations of the Martian Seasonal South Polar Cap From Co‐Registration of MOLA Profiles
Authors: Xiao Haifeng , Stark Alexander , Schmidt Frédéric , Hao Jingyan , Su Shu , Steinbrügge Gregor , Oberst Jürgen 
Published: July 2022

AbstractThe seasonal deposition and sublimation of CO2 represents a major element in the Martian volatile cycle. Here, co‐registration strategies are applied to Mars Orbiter Laser Altimeter profiles to obtain spatio‐temporal variations in snow/ice level of the Seasonal South Polar Cap (SSPC), in grid elements of 0.5° in latitude from 60° to 87°S and 10° in longitude. The maximum snow/ice level in the range of 2–2.5 m is observed over the Residual South Polar Cap. Peak level at the Residual South Polar Cap in Martian Year 25 (MY25) are found to be typically ∼0.5 m higher than those in MY24. The total volume is estimated to peak at approximately 9.4 × 1012 m3. In addition, a map of average bulk density of the SSPC during its recession is derived. It implies much more snowfall‐like precipitation at the Residual South Polar Cap and its surroundings than elsewhere on Mars.
Rapid bacterioplankton transcription cascades regulate organic matter utilization during phytoplankton bloom progression in a coastal upwelling system
Authors: Pontiller Benjamin , Martínez-García Sandra , Joglar Vanessa , Amnebrink Dennis , Pérez-Martínez Clara , González José M , Lundin Daniel , Fernández Emilio , Teira Eva , Pinhassi Jarone 
Published: July 2022

Abstract
Coastal upwelling zones are hotspots of oceanic productivity, driven by phytoplankton photosynthesis. Bacteria, in turn, grow on and are the principal remineralizers of dissolved organic matter (DOM) produced in aquatic ecosystems. However, the molecular processes that key bacterial taxa employ to regulate the turnover of phytoplankton-derived DOM are not well understood. We therefore carried out comparative time-series metatranscriptome analyses of bacterioplankton in the Northwest Iberian upwelling system, using parallel sampling of seawater and mesocosms with in situ-like conditions. The mesocosm experiment uncovered a taxon-specific progression of transcriptional responses from bloom development (characterized by a diverse set of taxa in the orders Cellvibrionales, Rhodobacterales, and Pelagibacterales), over early decay (mainly taxa in the Alteromonadales and Flavobacteriales), to senescence phases (Flavobacteriales and Saprospirales taxa). Pronounced order-specific differences in the transcription of glycoside hydrolases, peptidases, and transporters were found, supporting that functional resource partitioning is dynamically structured by temporal changes in available DOM. In addition, comparative analysis of mesocosm and field samples revealed a high degree of metabolic plasticity in the degradation and uptake of carbohydrates and nitrogen-rich compounds, suggesting these gene systems critically contribute to modulating the stoichiometry of the labile DOM pool. Our findings suggest that cascades of transcriptional responses in gene systems for the utilization of organic matter and nutrients largely shape the fate of organic matter on the time scales typical of upwelling-driven phytoplankton blooms.
Intracellular development and impact of a marine eukaryotic parasite on its zombified microalgal host
Authors: Decelle Johan , Kayal Ehsan , Bigeard Estelle , Gallet Benoit , Bougoure Jeremy , Clode Peta , Schieber Nicole , Templin Rachel , Hehenberger Elisabeth , Prensier Gerard , Chevalier Fabien , Schwab Yannick , Guillou Laure 
Published: July 2022

AbstractParasites are widespread and diverse in oceanic plankton and many of them infect single-celled algae for survival. How these parasites develop and scavenge energy within the host and how the cellular organization and metabolism of the host is altered remain open questions. Combining quantitative structural and chemical imaging with time-resolved transcriptomics, we unveil dramatic morphological and metabolic changes of the marine parasite Amoebophrya (Syndiniales) during intracellular infection, particularly following engulfment and digestion of nutrient-rich host chromosomes. Changes include a sequential acristate and cristate mitochondrion with a 200-fold increase in volume, a 13-fold increase in nucleus volume, development of Golgi apparatus and a metabolic switch from glycolysis (within the host) to TCA (free-living dinospore). Similar changes are seen in apicomplexan parasites, thus underlining convergent traits driven by metabolic constraints and the infection cycle. In the algal host, energy-producing organelles (plastid, mitochondria) remain relatively intact during most of the infection. We also observed that sugar reserves diminish while lipid droplets increase. Rapid infection of the host nucleus could be a “zombifying” strategy, allowing the parasite to digest nutrient-rich chromosomes and escape cytoplasmic defense, whilst benefiting from maintained carbon-energy production of the host cell.
Denture cleanliness and hygiene: an overview
Authors: Mylonas Petros , Milward Paul , McAndrew Robert 
Published: July 2022

AbstractDentures are an excellent treatment modality for partial and edentate patients; however, improper denture care and hygiene can result in both decreased longevity of the prosthesis and increased risk of developing dental caries, periodontal disease and oral candidosis. Previously, it has been shown that patients and dental professionals are unaware of the different materials and methods available for optimum denture care and hygiene. This article provides an overview of the key legislation and main commercially available methods for denture cleanliness and hygiene, and serves as a basis for providing tailored denture hygiene for denture wearers.
Stabilization of SAMHD1 by NONO is crucial for Ara-C resistance in AML
Authors: Zhang Feifei , Sun Jun , Tang Xiaofeng , Liang Yiping , Jiao Quanhui , Yu Bo , Dai Zhengzai , Yuan Xuhui , Li Jiayu , Yan Jinhua , Zhang Zhiping , Fan Song , Wang Min , Hu Haiyan , Zhang Changhua , Lv Xiao-Bin 
Published: July 2022

AbstractCytarabine (Ara-C) is the first-line drug for the treatment of acute myelogenous leukemia (AML). However, resistance eventually develops, decreasing the efficacy of Ara-C in AML patients. The expression of SAMHD1, a deoxynucleoside triphosphate (dNTP) triphosphohydrolase, has been reported to be elevated in Ara-C-resistant AML patients and to play a crucial role in mediating Ara-C resistance in AML. However, the mechanism by which SAMHD1 is upregulated in resistant AML remains unknown. In this study, NONO interacted with and stabilized SAMHD1 by inhibiting DCAF1-mediated ubiquitination/degradation of SAMHD1. Overexpression of NONO increased SAMHD1 expression and reduced the sensitivity of AML cells to Ara-C, and downregulation of NONO had the opposite effects. In addition, the DNA-damaging agents DDP and adriamycin (ADM) reduced NONO/SAMHD1 expression and sensitized AML cells to Ara-C. More importantly, NONO was upregulated in Ara-C-resistant AML cells, resulting in increased SAMHD1 expression in resistant AML cells, and DDP and ADM treatment resensitized resistant AML cells to Ara-C. This study revealed the mechanism by which SAMHD1 is upregulated in Ara-C-resistant AML cells and provided novel therapeutic strategies for Ara-C-resistant AML.
Natural killer cell awakening: unleash cancer-immunity cycle against glioblastoma
Authors: Wang Minjie , Zhou Zijie , Wang Xuan , Zhang Chaocai , Jiang Xiaobing 
Published: July 2022

AbstractDue to the negligence of the complex tumor immune microenvironment, traditional treatment for glioblastoma has reached its limitation and cannot achieve a satisfying outcome in the past decade. The emergence of immunotherapy based on the theory of cancer-immunity cycle has brought a new dawn to glioblastoma patients. However, the results of most phase II and phase III clinical trials are not optimistic due to the simple focus on T cells activation rather than other immune cells involved in anti-tumor immunity. NK cells play a critical role in both innate and adaptive immunity, having the ability to coordinate immune response in inflammation, autoimmune disease and cancer. They are expected to cooperate with T cells to maximize the anti-tumor immune effect and have great potential in treating glioblastoma. Here, we describe the traditional treatment methods and current immunotherapy strategies for glioblastoma. Then, we list a microenvironment map and discuss the reasons for glioblastoma inhibitory immunity from multiple perspectives. More importantly, we focus on the advantages of NK cells as potential immune regulatory cells and the ways to maximize their anti-tumor immune effect. Finally, our outlook on the directions and potential applications of NK cell-based therapy combining with the advance technologies is presented. This review depicts NK cell awakening as the precondition to unleash the cancer-immunity cycle against glioblastoma and elaborate this idea from biology to clinical treatment.
Nanomorphology dependence of the environmental stability of organic solar cells
Authors: Sung Woong , Lee Hansol , Choi Wookjin , Han Se Gyo , Kim Jimin , Cho Kwangwoo , Kim Seung Hyun , Lee Dongki , Kim Hyung Do , Ohkita Hideo , Cho Kilwon 
Published: July 2022

AbstractPrevious studies have reported contradictory effects of small-molecule acceptors on the environmental stability of polymer:small-molecule blends, with one showing that a small-molecule acceptor stabilizes and another showing that it destabilizes the polymer donor. In this work, to investigate the origin of these contradictory results, the effects of the nanomorphologies of small-molecule acceptors on the environmental stability of polymer:small-molecule blends are demonstrated. Investigations on the environmental stabilities of polymer:fullerene blends of poly[[4,8-bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b′]dithiophene-2,6-diyl][3-fluoro-2-[(2-ethylhexyl)carbonyl]thieno[3,4-b]thiophenediyl]] (PTB7):phenyl-C61-butyric acid methyl ester (PCBM) with contrasting nanomorphologies of PCBM reveal that dispersed PCBM in a mixed phase is the critical factor that causes triplet-mediated singlet oxygen generation and, hence, the severe photooxidation of PTB7, whereas an aggregated PCBM phase stabilizes PTB7 by reducing the formation of PTB7 triplet excitons. In addition, the photooxidation of PTB7 substantially degrades hole transport in the PTB7:PCBM blends by destroying the crystalline PTB7 phases within the films; this effect is strongly correlated with the efficiency losses of the PTB7:PCBM organic solar cells. These conclusions are also extended to polymer:nonfullerene blends of PTB7:ITIC and PTB7:Y6, thereby confirming the generality of this phenomenon for polymer:small-molecule organic solar cells.
Recurrent somatic mutations as predictors of immunotherapy response
Authors: Gajic Zoran Z. , Deshpande Aditya , Legut Mateusz , Imieliński Marcin , Sanjana Neville E. 
Published: July 2022

AbstractImmune checkpoint blockade (ICB) has transformed the treatment of metastatic cancer but is hindered by variable response rates. A key unmet need is the identification of biomarkers that predict treatment response. To address this, we analyzed six whole exome sequencing cohorts with matched disease outcomes to identify genes and pathways predictive of ICB response. To increase detection power, we focus on genes and pathways that are significantly mutated following correction for epigenetic, replication timing, and sequence-based covariates. Using this technique, we identify several genes (BCLAF1, KRAS, BRAF, andTP53)and pathways (MAPK signaling, p53 associated, and immunomodulatory) as predictors of ICB response and develop the Cancer Immunotherapy Response CLassifiEr (CIRCLE). Compared to tumor mutational burden alone, CIRCLE led to superior prediction of ICB response with a 10.5% increase in sensitivity and a 11% increase in specificity. We envision that CIRCLE and more broadly the analysis of recurrently mutated cancer genes will pave the way for better prognostic tools for cancer immunotherapy.
Early life inflammation is associated with spinal cord excitability and nociceptive sensitivity in human infants
Authors: Cobo Maria M. , Green Gabrielle , Andritsou Foteini , Baxter Luke , Evans Fry Ria , Grabbe Annika , Gursul Deniz , Hoskin Amy , Mellado Gabriela Schmidt , van der Vaart Marianne , Adams Eleri , Bhatt Aomesh , Denk Franziska , Hartley Caroline , Slater Rebeccah 
Published: July 2022

AbstractImmune function and sensitivity to pain are closely related, but the association between early life inflammation and sensory nervous system development is poorly understood—especially in humans. Here, in term-born infants, we measure brain activity and reflex withdrawal activity (using EEG and EMG) and behavioural and physiological activity (using the PIPP-R score) to assess the impact of suspected early-onset neonatal infection on tactile- and noxious-evoked responses. We present evidence that neonatal inflammation (assessed by measuring C-reactive protein levels) is associated with increased spinal cord excitability and evoked brain activity following both tactile and noxious stimulation. There are early indications that this hyperalgesia could be maintained post-inflammation, supporting pre-clinical reports of early-life immune dysfunction influencing pain sensitivity in adults.
Lipolysis regulates major transcriptional programs in brown adipocytes
Authors: Markussen Lasse K. , Rondini Elizabeth A. , Johansen Olivia Sveidahl , Madsen Jesper G. S. , Sustarsic Elahu G. , Marcher Ann-Britt , Hansen Jacob B. , Gerhart-Hines Zachary , Granneman James G. , Mandrup Susanne 
Published: July 2022

Abstractβ-Adrenergic signaling is a core regulator of brown adipocyte function stimulating both lipolysis and transcription of thermogenic genes, thereby expanding the capacity for oxidative metabolism. We have used pharmacological inhibitors and a direct activator of lipolysis to acutely modulate the activity of lipases, thereby enabling us to uncover lipolysis-dependent signaling pathways downstream of β-adrenergic signaling in cultured brown adipocytes. Here we show that induction of lipolysis leads to acute induction of several gene programs and is required for transcriptional regulation by β-adrenergic signals. Using machine-learning algorithms to infer causal transcription factors, we show that PPARs are key mediators of lipolysis-induced activation of genes involved in lipid metabolism and thermogenesis. Importantly, however, lipolysis also activates the unfolded protein response and regulates the core circadian transcriptional machinery independently of PPARs. Our results demonstrate that lipolysis generates important metabolic signals that exert profound pleiotropic effects on transcription and function of cultured brown adipocytes.
A charge transfer framework that describes supramolecular interactions governing structure and properties of 2D perovskites
Authors: Zhao Xiaoming , Ball Melissa L. , Kakekhani Arvin , Liu Tianran , Rappe Andrew M. , Loo Yueh-Lin 
Published: July 2022

AbstractThe elucidation of structure-to-function relationships for two-dimensional (2D) hybrid perovskites remains a primary challenge for engineering efficient perovskite-based devices. By combining insights from theory and experiment, we describe the introduction of bifunctional ligands that are capable of making strong hydrogen bonds within the organic bilayer. We find that stronger intermolecular interactions draw charge away from the perovskite layers, and we have formulated a simple and intuitive computational descriptor, the charge separation descriptor (CSD), that accurately describes the relationship between the Pb-I-Pb angle, band gap, and in-plane charge transport with the strength of these interactions. A higher CSD value correlates to less distortion of the Pb-I-Pb angle, a reduced band gap, and higher in-plane mobility of the perovskite. These improved material properties result in improved device characteristics of the resulting solar cells.
Late Miocene Tarim desert wetting linked with eccentricity minimum and East Asian monsoon weakening
Authors: Nie Junsheng , Wang Weihang , Heermance Richard , Gao Peng , Xing Li , Zhang Xiaojian , Zhang Ran , Garzione Carmala , Xiao Wenjiao 
Published: July 2022

AbstractPeriodic wetting is an inherent feature of many monsoon marginal region deserts. Previous studies consistently demonstrate desert wetting during times of Earth’s high orbital eccentricity and strong summer monsoon. Here we report the first evidence demonstrating desert wetting during Earth’s low orbital eccentricity from the late Miocene strata of the northwestern Tarim Basin of northern China, which is commonly thought to be beyond the range of Asian monsoon precipitation. Using mechanisms for modern Tarim wetting as analogs, we propose that East Asian summer monsoon weakening enhanced westward moisture transport and caused opposite desert wetting pattern to that observed in monsoon marginal region deserts. This inference is supported by our model simulations. This result has far-reaching implications for understanding environmental variations in non-monsoonal deserts in the next few thousands of years under high atmospheric CO2 content and low eccentricity.
Electrochemical aromatic C–H hydroxylation in continuous flow
Authors: Long Hao , Chen Tian-Sheng , Song Jinshuai , Zhu Shaobin , Xu Hai-Chao 
Published: July 2022

AbstractThe direct hydroxylation of arene C–H bonds is a highly sought-after transformation but remains an unsolved challenge due to the difficulty in efficient and regioselective C–H oxygenation and high reactivity of the phenolic products leading to overoxidation. Herein we report electrochemical C–H hydroxylation of arenes in continuous flow for the synthesis of phenols. The method is characterized by broad scope (compatible with arenes of diverse electronic properties), mild conditions without any catalysts or chemical oxidants, and excellent scalability as demonstrated by the continuous production of 1 mol (204 grams) of one of the phenol products.
Subnanometric Ru clusters with upshifted D band center improve performance for alkaline hydrogen evolution reaction
Authors: Hu Qi , Gao Keru , Wang Xiaodeng , Zheng Hongju , Cao Jianyong , Mi Lingren , Huo Qihua , Yang Hengpan , Liu Jianhong , He Chuanxin 
Published: July 2022

AbstractSubnanometric metal clusters usually have unique electronic structures and may display electrocatalytic performance distinctive from single atoms (SAs) and larger nanoparticles (NPs). However, the electrocatalytic performance of clusters, especially the size-activity relationship at the sub-nanoscale, is largely unexplored. Here, we synthesize a series of Ru nanocrystals from single atoms, subnanometric clusters to larger nanoparticles, aiming at investigating the size-dependent activity of hydrogen evolution in alkaline media. It is found that the d band center of Ru downshifts in a nearly linear relationship with the increase of diameter, and the subnanometric Ru clusters with d band center closer to Femi level display a stronger water dissociation ability and thus superior hydrogen evolution activity than SAs and larger nanoparticles. Benefiting from the high metal utilization and strong water dissociation ability, the Ru clusters manifest an ultrahigh turnover frequency of 43.3 s−1 at the overpotential of 100 mV, 36.1-fold larger than the commercial Pt/C.
Visual timing-tuned responses in human association cortices and response dynamics in early visual cortex
Authors: Hendrikx Evi , Paul Jacob M. , van Ackooij Martijn , van der Stoep Nathan , Harvey Ben M. 
Published: July 2022

AbstractQuantifying the timing (duration and frequency) of brief visual events is vital to human perception, multisensory integration and action planning. Tuned neural responses to visual event timing have been found in association cortices, in areas implicated in these processes. Here we ask how these timing-tuned responses are related to the responses of early visual cortex, which monotonically increase with event duration and frequency. Using 7-Tesla functional magnetic resonance imaging and neural model-based analyses, we find a gradual transition from monotonically increasing to timing-tuned neural responses beginning in the medial temporal area (MT/V5). Therefore, across successive stages of visual processing, timing-tuned response components gradually become dominant over inherent sensory response modulation by event timing. This additional timing-tuned response component is independent of retinotopic location. We propose that this hierarchical emergence of timing-tuned responses from sensory processing areas quantifies sensory event timing while abstracting temporal representations from spatial properties of their inputs.