bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Affecting Stiffness-Related Functional Disability After Long Segmental Fusion for Adult Spinal Deformity
Authors: Park Se-Jun , Lee Chong-Suh , Kang Byeong-Jik , Raj Aditya , Shin Tae-Soo , Park Jin-Sung 
Published: August 2022

BACKGROUND:
In general, stiffness-related functional disability (SRFD) is expected to increase as longer fusion length, but there have been no studies on factors affecting SRFD besides fusion length.

OBJECTIVE:
To identify the factors affecting SRFD after long segmental fusion in patients with adult spinal deformity (ASD).

METHODS:
We retrospectively reviewed the patients who underwent ≥4-segment fusion including sacrum for ASD. The severity of SRFD was evaluated using the Specific Functional Disability Index (SFDI) consisting of 12 items with 4 categories as follows: sitting on the floor, sanitation activity, lower body activity, and moving activity. Each category contains 3 items which was given a maximum of 4 points. The presumed factors affecting SFDI were analyzed.

RESULTS:
A total of 148 patients were included in the study with their mean age of 67.3 years. The mean fusion length was 6.4 segments. The mean score of each SFDI category was highest in sitting on the floor (9.9), followed by lower body activities (7.6), sanitation activities (6.0), and moving activities (5.9). The total sum was 29.3 points. In multivariate analysis, total sum of SFDI was significantly higher in female sex, patients with higher American Society of Anesthesiology grade, and longer fusion length. However, the sagittal parameters did not show a significant correlation with SRFD, except pelvic incidence-lumbar lordosis which correlated with only one category (lower body activities).

CONCLUSION:
This study showed that female sex, higher American Society of Anesthesiology grades, and longer fusion length influenced SRFD after long segmental fusion for ASD. Sagittal parameters related to the degree of deformity correction did not significantly affect SRFD.
Initial Experience With the NICO Myriad Device for Minimally Invasive Endoscopic Evacuation of Intracerebral Hemorrhage
Authors: Song Rui , Ali Muhammad , Smith Colton , Jankowitz Brian , Hom Danny , Mocco J , Kellner Christopher P. 
Published: August 2022

BACKGROUND:
Intracerebral hemorrhage (ICH) is a devastating form of stroke for which there is no consensus treatment. Although open craniotomy has been explored as a surgical treatment option, multiple minimally invasive (MIS) techniques have been developed including endoscopic evacuation. An adjunctive aspiration device can be used through the working channel to provide an additional degree of freedom and increased functionality regarding clot manipulation and morcellation.

OBJECTIVE:
To report our single-center technical experience with the Myriad device used as an adjunctive aspiration device during endoscopic ICH evacuation in an exploratory case series.

METHODS:
Demographic, clinical, and radiographic data were collected on patients who underwent MIS endoscopic ICH evacuation using the Myriad aspiration device from December 2018 to March 2019.

RESULTS:
Eight patients underwent ICH evacuation with the Myriad aspiration device. Bleeding was confined to the cortex in 4 patients, subcortical region in 2 patients, and the cerebellum in 2 patients. One of the cerebellar cases also underwent suboccipital craniotomy. The mean preoperative hematoma volume was 65.1 ± 68.9 mL, and the median postoperative volume was 7.6 ± 9.0 mL, for an average evacuation percentage of 88.1% ± 12.1%. In 75% of the cases, a bleeding vessel was identified and treated with either cautery or irrigation alone. There was no hemorrhagic recurrence or mortality within 30 days.

CONCLUSION:
Data from this initial experience suggest that MIS endoscopic ICH evacuation with the NICO Myriad aspiration device is feasible and technically effective. Multicenter exposure is necessary to verify broader applicability.
Surgery for Epilepsy Involving Rolandic and Perirolandic Cortex: A Case Series Assessing Complications and Efficacy
Authors: Jiang Shize , Lang Liqin , Sun Bing , Wu Dongyan , Feng Rui , He Juanjuan , Chen Liang , Hu Jie , Mao Ying 
Published: August 2022

BACKGROUND:
Surgical removal of lesions around the rolandic cortex remains a challenge for neurosurgeons owing to the high risk of neurological deficits. Evaluating the risk factors associated with motor deficits after surgery in this region may help reduce the occurrence of motor deficits.

OBJECTIVE:
To report our surgical experience in treating epileptic lesions involving the rolandic and perirolandic cortices.

METHODS:
We performed a single-center retrospective review of patients undergoing epilepsy surgeries with lesions located in the rolandic and perirolandic cortices. Patients with detailed follow-up information were included. The lesion locations, resected regions, and invasive exploration techniques were studied to assess their relationship with postoperative motor deficits.

RESULTS:
Forty-one patients were included. Twenty-three patients suffered from a transient motor deficit, and 2 had permanent disabilities after surgery. Six patients with lesions at the posterior bank of the precentral sulcus underwent resection, and 5 experienced short-term motor deficits. Two patients with lesions adjacent to the anterior part of the precentral gyrus, in whom the adjacent precentral gyrus was removed, experienced permanent motor deficits. Lesions located at the bottom of the central sulcus and invading the anterior bank of the central sulcus were observed in 3 patients. The patients did not experience permanent motor deficits after surgery.

CONCLUSION:
The anterior bank of the central sulcus is indispensable for motor function, and destruction of this region would inevitably cause motor deficits. The anterior bank of the precentral gyrus can also be removed without motor impairment if there is a preexisting epileptogenic lesion.
The serine/threonine kinase MINK1 directly regulates the function of promigratory proteins
Authors: Daulat Avais M. , Wagner Mônica S. , Audebert Stéphane , Kowalczewska Malgorzata , Ariey-Bonnet Jeremy , Finetti Pascal , Bertucci François , Camoin Luc , Borg Jean-Paul 
Published: August 2022

ABSTRACT
Upregulation of the developmental Wnt planar cell polarity (Wnt/PCP) pathway is observed in many cancers and is associated with cancer development. We have recently shown that PRICKLE1, a core Wnt/PCP pathway component, is a marker of poor prognosis in triple-negative breast cancer (TNBC). PRICKLE1 is phosphorylated by the serine/threonine kinase MINK1 and contributes to TNBC cell motility and invasiveness. However, the identity of the substrates of MINK1 and the role of MINK1 enzymatic activity in this process remain to be addressed. We used a phosphoproteomic strategy to identify MINK1 substrates, including LL5β (also known as PHLDB2). LL5β anchors microtubules at the cell cortex through its association with CLASP proteins to trigger focal adhesion disassembly. LL5β is phosphorylated by MINK1, promoting its interaction with CLASP proteins. Using a kinase inhibitor, we demonstrate that the enzymatic activity of MINK1 is involved in PRICKLE1–LL5β complex assembly and localization, as well as in cell migration. Analysis of gene expression data reveals that the concomitant upregulation of levels of mRNA encoding PRICKLE1 and LL5β, which are MINK1 substrates, is associated with poor metastasis-free survival in TNBC patients. Taken together, our results suggest that MINK1 may represent a potential target for treatment of TNBC.
Rerouting trafficking circuits through posttranslational SNARE modifications
Authors: Warner Harry , Mahajan Shweta , van den Bogaart Geert 
Published: August 2022

ABSTRACT
Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are membrane-associated trafficking proteins that confer identity to lipid membranes and facilitate membrane fusion. These functions are achieved through the complexing of Q-SNAREs with a specific cognate target R-SNARE, leading to the fusion of their associated membranes. These SNARE complexes then dissociate so that the Q-SNAREs and R-SNAREs can repeat this cycle. Whilst the basic function of SNAREs has been long appreciated, it is becoming increasingly clear that the cell can control the localisation and function of SNARE proteins through posttranslational modifications (PTMs), such as phosphorylation and ubiquitylation. Whilst numerous proteomic methods have shown that SNARE proteins are subject to these modifications, little is known about how these modifications regulate SNARE function. However, it is clear that these PTMs provide cells with an incredible functional plasticity; SNARE PTMs enable cells to respond to an ever-changing extracellular environment through the rerouting of membrane traffic. In this Review, we summarise key findings regarding SNARE regulation by PTMs and discuss how these modifications reprogramme membrane trafficking pathways.
Cross-Trained Fire-Medics Respond to Medical Calls and Fire Incidents: A Fast Algorithm for a Three-State Spatial Queuing Problem
Authors: Hua Cheng , Swersey Arthur J. 
Published: August 2022

Problem definition: We focus on modeling and evaluating an emergency service system in which cross-trained fire-medics are pooled and respond to both fire calls and medical emergencies. Academic/practical relevance: Fire demand in the United States has decreased dramatically in the last nearly four decades, whereas emergency medical calls have surged. With this changing landscape, cities are under pressure to reduce their budgets by closing fire stations. We evaluate the alternative of implementing a fire-medic system in terms of cost savings and response time performance. Methodology: A cross-trained fire-medic unit may be in one of three states: available, busy at an emergency medical incident, or busy at a fire call. An exact model for the fire-medic system has exponential complexity. We develop a fast approximation algorithm that has linear complexity and can be used to solve three-state problems of any size. Results: Our approximation algorithm yields accurate predictions of response times and unit workloads and provides rapid solution times. We apply our model to the fire-medic system in St. Paul, MN, and find close agreement between predicted and actual average response times. A traditional system would require 33% more personnel to achieve about the same average response times. In sensitivity analyses, we show that the fire-medic system outperforms a traditional system over a wide range of values for call rates and number of joint units. Managerial implications: The fire-medic system in St. Paul, MN, saves more than three million dollars annually. The greatest benefit of the fire-medic system is in reducing response times to medical emergencies. We also show that in a fire-medic system that includes separate engine units, it is advantageous to convert the separate engines to fire-medic units. Our fast approximation algorithm can be applied even in the largest cities that implement fire-medic systems to improve resource deployment and reduce costs. Funding: This work was supported by the Shanghai Science and Technology Development Foundation [Grant 21YF1420200]. Supplemental Material: The e-companion is available at https://doi.org/10.1287/msom.2022.1140 .
Partial Recovery in the Graph Alignment Problem
Authors: Hall Georgina , Massoulié Laurent 
Published: August 2022

Partially Recovering a Graph Alignment in the Correlated Erdös–Renyi Model Given two graphs, how can we partially recover a one-to-one mapping between nodes that maximizes edge overlap? This problem, known as the graph alignment problem, appears in settings such as social network deanonymization and cellular biology. In “Partial Recovery in the Graph Alignment Problem,” G. Hall and L. Massoulié consider a stylized mathematical model of problems of this type: they assume that the input graphs are generated via a probabilistic model, namely, the correlated Erdös–Renyi model with parameters (n, q, s). They provide both necessary and sufficient conditions on (n, q, s) under which partial recovery can be achieved. In particular, they show that partial recovery can be achieved in the nqs = Ɵ(1) regime under certain additional assumptions.
Application of the SCAI classification to admission of patients with cardiogenic shock: Analysis of a tertiary care center in a middle-income country
Authors: González-Pacheco Héctor , Gopar-Nieto Rodrigo , Araiza-Garaygordobil Diego , Briseño-Cruz José Luis , Eid-Lidt Guering , Ortega-Hernandez Jorge Arturo , Sierra-Lara Daniel , Altamirano-Castillo Alfredo , Mendoza-García Salvador , Manzur-Sandoval Daniel , Aguilar-Montaño Klayder Melissa , Ontiveros-Mercado Heriberto , García-Espinosa Jorge Iván , Pérez-Pinetta Pablo Esteban , Arias-Mendoza Alexandra 
Published: August 2022

AimsThe Society of Cardiovascular Angiography and Interventions (SCAI) shock stages have been applied and validated in high-income countries with access to advanced therapies. We applied the SCAI scheme at the time of admission in order to improve the risk stratification for 30-day mortality in a retrospective cohort of patients with STEMI in a middle-income country hospital at admission.MethodsThis is a retrospective cohort study, we analyzed 7,143 ST-segment elevation myocardial infarction (STEMI) patients. At admission, patients were stratified by the SCAI shock stages. Multivariate analysis was used to assess the association between SCAI shock stages to 30-day mortality.ResultsThe distribution of the patients across SCAI shock stages was 82.2%, 9.3%, 1.2%, 1.5%, and 0.8% to A, B, C, D, and E, respectively. Patients with SCAI stages C, D, and E were more likely to have high-risk features. There was a stepwise significant increase in unadjusted 30-day mortality across the SCAI shock stages (6.3%, 8.4%, 62.4%, 75.2% and 88.3% for A, B, C, D and E, respectively; P < 0.0001, C-statistic, 0.64). A trend toward a lower 30-day survival probability was observed in the patients with advanced CS (30.3, 15.4%, and 8.3%, SCAI shock stages C, D, and E, respectively, Log-rank P-value <0.0001). After multivariable adjustment, SCAI shock stages C, D, and E were independently associated with an increased risk of 30-day death (hazard ratio 1.42 [P = 0.02], 2.30 [P<0.0001], and 3.44 [P<0.0001], respectively).ConclusionThe SCAI shock stages applied in patients con STEMI at the time of admission, is a useful tool for risk stratification in patients across the full spectrum of CS and is a predictor of 30-day mortality.
Use of a Cirrhosis Admission Order Set Improves Adherence to Quality Metrics and May Decrease Hospital Length of Stay
Authors: Bhavsar-Burke Indira , Guardiola John J. , Hamade Nour , Gerke Steven , Burke Sean M. , Merrill Katherine , Mulvey Karalea D. , Orman Eric S. , Fayad Nabil 
Published: August 2022

INTRODUCTION:
Quality metrics for inpatient cirrhosis management have been created to improve processes of care. We aimed to improve adherence to quality metrics by creating a novel clinical decision support (CDS) tool in the electronic health record (EHR).

METHODS:
We developed and piloted an alert system in the EHR that directs providers to a cirrhosis order set for patients who have a known diagnosis of cirrhosis or are likely to have cirrhosis. Adherence to process measures and outcomes when the CDS was used were compared with baseline performance before the implementation of the CDS.

RESULTS:
The use of the order set resulted in a significant increase in adherence to process measures such as diagnostic paracentesis (29.6%–51.1%), low-sodium diet (34.3%–77.8%), and social work involvement (36.6%–88.9%) (P < 0.001 for all). There were also significant decreases in both intensive care and hospital lengths of stay (P < 0.001) as well as in-hospital development of infection (P = 0.002). There was no difference in hospital readmissions at 30 or 90 days between the groups (P = 0.897, P = 0.640).

DISCUSSION:
The use of CDS in EHR-based interventions improves adherence to quality metrics for patients with cirrhosis and could easily be shared by institutions through EHR platforms. Further studies and larger sample sizes are needed to better understand its impact on additional outcome measures.
Low Prevalence of Endoscopic Screening for Barrett's Esophagus in a Screening-Eligible Primary Care Population
Authors: Eluri Swathi , Reddy Sumana , Ketchem Corey C. , Tappata Manaswita , Nettles Hanna G , Watts Ariel E. , Cotton Cary C. , Dellon Evan S. , Shaheen Nicholas J. 
Published: August 2022

INTRODUCTION:
Despite societal recommendations supporting Barrett's esophagus (BE) screening, it is unknown what proportion of eligible patients is screened in primary care. We assessed the proportion of BE screening- eligible patients evaluated in the primary care setting receiving upper esophagogastroduodenoscopy (EGD) and identified factors associated with undergoing EGD.

METHODS:
This was a retrospective study of BE screening-eligible patients, as defined by the American College of Gastroenterology's BE guidelines, in a multipractice healthcare network consisting of 64 internal medicine practices and 94 family medicine (FM) practices. The proportion undergoing EGD, prevalence of BE and esophageal adenocarcinoma (EAC) in this group, and patient and provider factors associated with undergoing EGD were assessed. Multivariable logistic regression was performed to identify independent predictors of undergoing EGD.

RESULTS:
Of 1,127 screening-eligible patients, the mean age was 65.2 ± 8.6 years; 45% were obese; and 61% were smokers. Seventy-three percent were seeing FM; 94% were on proton pump inhibitors; and 44% took ≥1 gastroesophageal reflux disease (GERD) medication. Only 39% of patients (n = 436) had undergone EGD. The overall prevalence of BE or EAC was 9.9%. Of 39 (9%) referred for BE screening as the primary indication, BE/EAC prevalence was 35.1%. Factors associated with increased odds of having EGD were symptomatic GERD despite treatment (odds ratio [OR] 12.1, 95% confidence interval [CI] 9.1‐16.3), being on ≥1 GERD medication (OR 1.4, 95% CI 1.0‐1.9), and being an FM patient (OR 1.5, 95% CI 1.1‐2.1).

DISCUSSION:
In this large, primary care population, only 39% of screening-eligible patients underwent EGD. Most of the examinations were triggered by refractory symptoms rather than screening referrals, highlighting a need for improved dissemination and implementation of BE screening.
Long-Term Outcomes of the Six-Food Elimination Diet and Food Reintroduction in a Large Cohort of Adults With Eosinophilic Esophagitis
Authors: Zalewski Angelika , Doerfler Bethany , Krause Amanda , Hirano Ikuo , Gonsalves Nirmala 
Published: August 2022

INTRODUCTION:
Eosinophilic esophagitis (EoE) is an immune-mediated inflammatory condition with tissue eosinophilia resulting in esophageal dysfunction. The six-food elimination diet (SFED) is an EoE treatment approach that removes milk, wheat, soy, eggs, tree nuts/peanuts, and fish/shellfish. After histologic remission, food reintroduction occurs to identify a food trigger. Outcomes from large series of adults undergoing SFED and food reintroduction as clinical care are not known.

METHODS:
A retrospective review (2006–2021) of adult patients with EoE from an academic center was completed. Patients were classified as full responders (<15 eos/hpf) after SFED. If reintroduction was pursued, food triggers identified were recorded.

RESULTS:
Two hundred thirteen patients completed SFED. One hundred fifteen patients (54%) had response <15 eos/hpf after SFED. Seventy-seven percent of responders had symptom improvement. Thirty-two percent of initial nonresponders underwent repeat dietary elimination. Fifty-eight percent of patients (n = 123) achieved <15 eos/hpf after either initial or extended SFED. Seventy-eight percent of responders underwent food reintroduction. Sixty-nine percent had 1 food trigger identified, 24% had 2 allergens identified, and 4% had 3 allergens identified. The most common food triggers identified were milk, wheat, and soy.

DISCUSSION:
This study describes the largest cohort reported of adult patients with EoE completing SFED with food reintroduction. The overall SFED histologic response was 54%, which increased to 58% with 1 additional round of dietary therapy, suggesting that 31% may respond in a second attempt. Most patients who completed food reintroduction had a single food trigger identified. Dietary elimination with specific food trigger identification is a feasible alternative to medical therapy for adults with EoE.
Intrapancreatic, Liver, and Skeletal Muscle Fat Depositions in First Attack of Acute Pancreatitis Versus Health
Authors: Ko Juyeon , Al-Ani Zena , Long Kieran , Tarrant Conor , Skudder-Hill Loren , Petrov Maxim S. 
Published: August 2022

INTRODUCTION:
Increased intrapancreatic fat deposition (IPFD) has emerged as a harbinger of pancreatic cancer and chronic pancreatitis. Although it is well recognized that diseases of the exocrine pancreas often lie on a continuum (with acute pancreatitis preceding the development of chronic pancreatitis and/or pancreatic cancer), whether increased IPFD predisposes to acute pancreatitis is unknown. This study aimed to compare fat depositions in the pancreas (as well as the liver and skeletal muscle) between individuals who developed first attack of acute pancreatitis and healthy individuals.

METHODS:
This was a matched case-control study nested into population-based cohort. MRI on a single 3 T scanner was used to quantify intrapancreatic, liver, and skeletal muscle fat depositions using the same protocols in all study participants. Binary logistic regression with adjustment for body mass index and other possible confounders was performed.

RESULTS:
Fifty individuals with first attack of nonnecrotizing acute pancreatitis comprised the case group and 100 healthy individuals comprised the control group. A 1% increase in IPFD (but not the other fat depositions) was significantly associated with a more than 30% higher chance of developing first attack of acute pancreatitis, consistently in both the unadjusted (P = 0.004) and all adjusted models. Furthermore, a 1% increase in IPFD (but not the other fat depositions) was significantly associated with up to a 27% higher chance of developing first attack of acute pancreatitis in individuals with normotriglyceridemia, consistently in both the unadjusted (P = 0.030) and all adjusted models.

DISCUSSION:
Increased IPFD may predispose to the development of acute pancreatitis. This opens up opportunities for reducing the burden of acute pancreatitis by means of primary prevention.