bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and clinical features of anxiety disorders: Tunisian study about 436 subjects
Authors: Jabeur M. , Gassab L. , Ayadi A. , Ben Mohamed B. , Zaafrane F. , Gaha L. 
Published: September 2022

IntroductionAnxiety disorders represent one of the most common mental disorders following a chronic course.ObjectivesThe aim of our study is to determine the prevalence, incidence and clinical characteristics of these disorders.MethodsWe conducted a retrospective and descriptive study about 436 outpatients fulfilling the DSM-V diagnostic criteria for anxiety disorder and followed in the department of psychiatry of Monastir (Tunisia) between 1998 and 2017. Selective mutism and separation anxiety were excluded for lack of cases.ResultsThe overall prevalence was 5.51%. Panic Disorder was the most prevalent anxiety disorder subtype (3.2%). The incidence of anxiety disorders in the last years has increased from 3.31% in 1998 to 7.5% in 2017. The mean age at diagnosis was 37.76±12.87 years [16-77]. Female gender was the most prevalent in overall anxiety disorders with a sex ratio of 0.78, however, a significant male predominance was recorded in Social Anxiety Disorder (SAD) with a sex ratio of 1.85. Generalized Anxiety Disorder patients were more likely to have low educational level (OR= 1.879), to be laborers (OR=2.55), to be married (OR=2.418) and to have children (OR=2.564) whereas SAD patients were more likely to have higher education (OR=9.118), to be students (OR=5.565), to be single (OR=11.325) and have no children (OR=7.464).ConclusionsThis study highlignts the frequency of anxiety disorders and the fact that being a middle-age married woman with kids make oneself more prone to have an anxiety disorder. Specific attention should be paid to these anxiety disorders with early preventive programs.DisclosureNo significant relationships.
Clinical and Molecular Determinants of Clonal Evolution in Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria
Authors: Gurnari Carmelo , Pagliuca Simona , Prata Pedro Henrique , Galimard Jacques-Emmanuel , Catto Luiz Fernando B. , Larcher Lise , Sebert Marie , Allain Vincent , Patel Bhumika J. , Durmaz Arda , Pinto Andre L. , Inacio Mariana C.B. , Hernandez Lucie , Dhedin Nathalie , Caillat-Zucman Sophie , Clappier Emmanuelle , Sicre de Fontbrune Flore , Voso Maria Teresa , Visconte Valeria , Peffault de Latour Régis , Soulier Jean , Calado Rodrigo T. , Socié Gérard , Maciejewski Jaroslaw P. 
Published: September 2022

PURPOSE Secondary myeloid neoplasms (sMNs) remain the most serious long-term complications in patients with aplastic anemia (AA) and paroxysmal nocturnal hemoglobinuria (PNH). However, sMNs lack specific predictors, dedicated surveillance measures, and early therapeutic interventions. PATIENTS AND METHODS We studied a multicenter, retrospective cohort of 1,008 patients (median follow-up 8.6 years) with AA and PNH to assess clinical and molecular determinants of clonal evolution. RESULTS Although none of the patients transplanted upfront (n = 117) developed clonal complications (either sMN or secondary PNH), the 10-year cumulative incidence of sMN in nontransplanted cases was 11.6%. In severe AA, older age at presentation and lack of response to immunosuppressive therapy were independently associated with increased risk of sMN, whereas untreated patients had the highest risk among nonsevere cases. The elapsed time from AA to sMN was 4.5 years. sMN developed in 94 patients. The 5-year overall survival reached 40% and was independently associated with bone marrow blasts at sMN onset. Myelodysplastic syndrome with high-risk phenotypes, del7/7q, and ASXL1, SETBP1, RUNX1, and RAS pathway gene mutations were the most frequent characteristics. Cross-sectional studies of clonal dynamics from baseline to evolution revealed that PIGA/human leukocyte antigen lesions decreased over time, being replaced by clones with myeloid hits. PIGA and BCOR/L1 mutation carriers had a lower risk of sMN progression, whereas myeloid driver lesions marked the group with a higher risk. CONCLUSION The risk of sMN in AA is associated with disease severity, lack of response to treatment, and patients' age. sMNs display high-risk morphological, karyotypic, and molecular features. The landscape of acquired somatic mutations is complex and incompletely understood and should be considered with caution in medical management.
Optimization of Meloxicam Solid Dispersion Formulations for Dissolution Enhancement and Storage Stability Using 33 Full Factorial Design Based on Response Surface Methodology
Authors: Emam Maha F. , El-Ashmawy Ahmed A. , Mursi Nadia M. , Emara Laila H. 
Published: September 2022

AbstractThis study aimed to formulate and optimize solid-dispersion of meloxicam (MX) employing response-surface-methodology (RSM). RSM allowed identification of the main effects and interactions between studied factors on MX dissolution and acceleration of the optimization process. 33 full factorial design with 27 different formulations was proposed. Effects of drug loading percentage (A), carriers’ ratio (B), method of preparation (C), and their interactions on percent MX dissolved after 10 and 30 min (Q10min & Q30min) from fresh and stored samples were studied in distilled water. The considered levels were 2.5%, 5.0%, and 7.5% (factor A), three ratios of Soluplus®/Poloxamer-407 (factor B). Physical mixture (PM), fusion method (FM), and hot-melt-extrusion (HME) were considered factor (C). Stability studies were carried out for 3 months under stress conditions. The proposed optimization design was validated by 3-extra checkpoints formulations. The optimized formulation was selected via numerical optimization and investigated by DSC, XRD, PLM, and in vitro dissolution study. Results showed that HME technique gave the highest MX dissolution rate compared to other techniques (FM & PM). At constant level of factor (C), the amount of MX dissolved increased by decreasing MX loading and increasing Soluplus in carriers’ ratio. Actual responses of the optimized formulation were in close consistency with predicted data. Amorphous form of MX in the optimized formulation was proved by DSC, XRD, and PLM. Selected factors and their levels of the optimization design were significantly valuable for demonstrating and adapting the expected formulation characteristics for rapid dissolution of MX (Q10min= 89.09%) from fresh and stored samples.
Graphical abstract
Neutron Diffraction with 34S/natS Isotopic Substitution Method on the Solvation Structure of S8 Molecule in Concentrated CS2 Solutions
Authors: Kameda Yasuo , Arai Nana , Amo Yuko , Usuki Takeshi , Han Jihae , Watanabe Hikari , Umebayashi Yasuhiro , Tsuzuki Seiji , Ikeda Kazutaka , Otomo Toshiya 
Published: September 2022

Abstract
Neutron diffraction measurements on 34S/natS isotopically substituted (natS: natural abundance) 6.9 mol% *S8 solutions in CS2 (natural abundance for both S and C atoms) have successfully been carried out in order to examine the possibility of the 34S/natS isotopic difference method neutron diffraction for liquid samples and to obtain novel structural insights into both intramolecular structure and the solvation structure of S8 molecule in concentrated CS2 solutions. Intramolecular structural parameters within the S8 molecule as well as the intermolecular parameters concerning the nearest neighbor *S⋯CS2 interaction have been determined through the least squares fitting analysis of the observed difference interference function, ΔS(Q), which has been derived from the numerical difference between scattering cross sections observed for *S8 with 34S-enriched and natural S solutions in natural CS2. MD simulations were performed with newly developed force field parameters for sulfur atoms in S8 molecule. The results derived by the simulations adequately agree with the neutron experiments.
Effect of zinc ions on the lung and cutaneous diffusive respiration of the great ramshorn Planorbarius corneus allospecies (Mollusca: Gastropoda: Pulmonata: Planorbidae) of the Ukrainian river network
Authors: Babych Yuliia , Romaniuk Ruslana , Stadnychenko Agnessa , Uvayeva Olena 
Published: September 2022

Toxicological studies were performed to analyze the effect of Zn2+ in different concentrations on the lung and cutaneous diffusive respiration of great ramshorn Planorbarius corneus (Linnaeus, 1758) allospecies from the two geographically separate populations. At 0.5 MPC Zn2+ in the water containing experimental molluscs, there were no statistically significant changes in the number or duration of inspirations compared to the control. Increasing the concentration of toxicant to 2 MPC was accompanied by a sharp increase in both (p≤0.001), as also in the volume of inspirations (p≤0.05). Increasing concentrations to 5 and 10 MPC was followed by drastic and statistically significant impairments of pulmonary respiration indices. Avoidance also collapsed at these higher concentrations, and the accumulation of thick mucus inhibiting respiration resulted in heavy mortality. Trends were the same in both “western” and “eastern” allospecies, although the latter appeared marginally less resistant. The main reason for changes in respiratory function is the damage inflicted by toxicant on the lung and cutaneous respiratory epithelium. The effects are highly intensified production of mucus which completely blocks oxygen intake by cutaneous epithelium and induces cell death in the respiratory epithelium.
Θρησκευτικότητα και κοινωνικότητα Ελλήνων με κώφωση
Authors: Καραμούζης π. Ιωάννης 
Published: September 2022

Η παρούσα έρευνα έχει σκοπό να μελετήσει τις αντιλήψεις τριών ομάδων Ελλήνων με κώφωση σχετικά με τη θρησκεία, την επικοινωνία και την κώφωση. Το δείγμα ήταν 25 μαθητές Λυκείου Κωφών του Δήμου της Αγίας Παρασκευής Αθηνών, 25 χρήστες διαδικτύου και 10 ενεργά μέλη κάποιου σωματείου ατόμων με κώφωση. Χορηγήθηκαν ερωτηματολόγια κλειστού τύπου και οι απαντήσεις ερμηνεύτηκαν με την ποσοτική μέθοδο ανάλυσης. Τα κυριότερα ευρήματα είναι ότι οι μαθητές με κώφωση δε διατηρούν ενεργή σχέση με τη θρησκεία, γιατί δεν την κατανοούν. Θα ήθελαν να τη γνωρίσουν καλύτερα. Επίσης, επικοινωνούν κυρίως με άλλα άτομα με κώφωση, επειδή χρησιμοποιούν την ίδια γλώσσα, αλλά και με ακούοντες. Θεωρούν, τέλος, ότι είναι ισότιμοι με τους ακούοντες και όχι κατώτεροι από εκείνους.
Σύγκριση και μέτρηση επιφανειών από μαθήτρια με τύφλωση: Ο ρόλος της απτικής αντίληψης
Authors: Κόζα Μαρία , Σκουμπουρδή Χρυσάνθη 
Published: September 2022

Η αντίληψη μέσω της αφής είναι μια πολύ-αισθητηριακή διαδικασία που συν-διαμορφώνεται από ένα σύνολο πληροφοριών, οι οποίες συλλέγονται τόσο από την αφή όσο και από την κίνηση, αλλά και τη στάση του σώματος (κύριες πηγές πληροφοριών). Επιπλέον, συντελεστές που συμβάλλουν στην απτική αντίληψη είναι η γλωσσική ικανότητα, η προϋπάρχουσα γνώση, καθώς και το είδος και οι συνθήκες πραγματοποίησης μιας δραστηριότητας (δευτερεύουσες πηγές πληροφοριών). Η συγκεκριμένη εργασία αποτελεί μέρος ευρύτερης έρευνας, που στοχεύει στη διερεύνηση του τρόπου με τον οποίο διαμορφώνεται η απτική αντίληψη μαθητών/τριών με τύφλωση, χωρίς συνοδά προβλήματα για τη σύγκριση και τη μέτρηση επιφανειών, μέσα από την ανάλυση του ρόλου των πηγών πληροφοριών που χρησιμοποιούν. Στη συγκεκριμένη εργασία θα παρουσιαστεί η μελέτη της περίπτωσης μίας μαθήτριας με τύφλωση, 11 ετών. Από τα αποτελέσματα φάνηκε ότι η μαθήτρια μπόρεσε να συγκρίνει με επιτυχία τις επιφάνειες αντικειμένων με μέγεθος περίπου δύο παλάμες και αμελητέα την τρίτη διάσταση, αλλά όχι των αντικειμένων με μέγεθος μίας παλάμης και αισθητή την τρίτη διάσταση. Η μέτρηση ορθογώνιων επιφανειών δεν ήταν μια εύκολη διαδικασία για τη μαθήτρια παρόλο που είχε διδαχθεί τον τύπο εύρεσης του εμβαδού.
Οικογένεια και μαθησιακές δυσκολίες
Authors: Τσαμπαρλή Αναστασία 
Published: September 2022

Το άρθρο, το οποίο συνιστά μέρος μίας ευρύτερης εργασίας[1], πραγματεύεται τρία βασικά ζητήματα που σχετίζονται με τις οικογένειες με παιδί με μαθησιακές δυσκολίες. Ειδικότερα, μελετά: (1) τη δυναμική της οικογένειας, (2) τους παράγοντες στη λειτουργία της οικογένειας που ενισχύουν την ύπαρξη μαθησιακής δυσκολίας (Μ.Δ.) και (3) τον ρόλο της παρέμβασης. Η εργασία αναδεικνύει ότι η μαθησιακή δυσκολία (Μ.Δ.) επιδρά στη δυναμική των σχέσεων οικογένειας – παιδιού και αντίστροφα. Επίσης, η οικογένεια μπορεί να συμβάλει θετικά ή/και αρνητικά στην εξέλιξη ενός παιδιού με Μ.Δ. Τέλος, η αντιμετώπιση των μαθησιακών δυσκολιών δεν θα πρέπει να στοχεύει μόνο στο παιδί με Μ.Δ. αλλά και στο πλαίσια αλληλεπίδρασής του: Την οικογένεια, το σχολείο και την κοινότητα.
Κριτική θεώρηση της οικογένειας με παιδί με ειδικές εκπαιδευτικές ανάγκες
Authors: Τσιμπιδάκη Ασημίνα 
Published: September 2022

Το άρθρο, με αφόρμηση το κείμενο της Αναστασίας Τσαμπαρλή στην ενότητα Διάλογος, πραγματεύεται δύο βασικά ζητήματα, που σχετίζονται με τις οικογένειες που μεγαλώνουν ένα παιδί με ειδικές εκπαιδευτικές ανάγκες (ε.ε.α.). Ειδικότερα, μελετά: (1) την ερευνητική εργασία στις οικογένειες με παιδί με ειδικές εκπαιδευτικές ανάγκες, και (2) τη δυναμική αυτών των οικογενειών. Η εργασία αναδεικνύει ότι η έρευνα εμφανίζει αντικρουόμενα πορίσματα σχετικά με την επίδραση ενός παιδιού με ε.ε.α. στην οικογένεια και ότι αυτές οι οικογένειες εμφανίζουν μία ιδιαίτερη δυναμική, η οποία δεν τις καθιστά, ωστόσο, δυσλειτουργικές.
Women’s access to health care for non-communicable diseases in South Africa: A scoping review.
Authors: Gizamba Jacob , Davies Jess , Africa Chad , Choo-Kang Candice , Goedecke Julia , Madlala Hlengiwe , Lambert Estelle , Rae Dale , Myer Landon , Luke Amy , Dugas Lara R. 
Published: September 2022

Background: Non-communicable diseases (NCDs) such as obesity, hypertension (HPT), and type II diabetes (T2D) are of increasing concern in South Africa (SA), with women being more at risk. Authors conducted a scoping review to identify and map the evidence available about the barriers of access to obesity, HPT, and T2D care among women in SA. Methods: Arksey and O'Malley's framework for scoping review was used. The search of the literature was completed in the Scopus, Web of Science, and PubMed databases between April and May 2022. Only studies conducted among women in SA were eligible for inclusion. Identified barriers were mapped onto Levesque’s framework of access to health care to determine which points along the chain of accessing NCD health care among women are mostly impacted. Results: Seven articles were included in the review: qualitative (n=2), quantitative (n=2), mixed methods (n=2), and grey literature (n=1). The included studies reported barriers of access to HPT and T2D care only, and no study reported barriers to obesity care. Supply-side barriers included lack of knowledge about available services, physician heavy workloads, medicine stock-outs, limited availability of testing equipment, unaffordable transport costs, travelling longer distances, inefficiently longer waiting times, and delayed referral. Demand-side barriers included women having low self-awareness of NCD status, concerns about confidentiality, perceived discrimination, and poverty. Conclusions: Access to HPT and T2D services is impacted from perception of need to benefitting from care. Articles included identified barriers affecting the availability and accommodation dimension of access to care, suggesting that HPT and T2D care is often unavailable or that women are unable to reach health facilities or service providers. There is need for more and better-quality research about access to NCD health care in SA, especially among women having a disproportionately high burden of obesity, T2D, and HPT.
Case Report: A digital workflow in the treatment of bruxism in a young patient
Authors: Shopova Dobromira , Mladenov Krasimir 
Published: September 2022

Bruxism is increasingly common in today's stressful world and affects mainly young patients. It is a combined disease that involves dentition and its supporting structures, muscles, ligaments and the temporomandibular joint (TMJ). Here we present a complete combined analog and digital clinical protocol in a patient with parafunction. A young patient sought help due to impaired aesthetics, as a result of abraded tooth surfaces and severe symptoms of TMJ. We implemented a therapeutic protocol of six stages: deprogramming of the muscles and determination of treatment position and digital optimization; realization of the morphological plan for the upper dentition; non-invasive repositioning of the lower jaw by splint therapy; splint placement and follow-up; morphological planning of the lower dentition and replacement of the splint with fixed prosthesis with follow-up; and completion of the case with ceramic restorations. The digitally modeled temporary constructions for the upper jaw were made of PMMA and placed in the patient's mouth together with the splint on the lower jaw, made of Ceramill Splintec. After an adaptation period, all restorations were replaced by permanent zirconia. We achieved restoration of the defects of the dental arches and hard dental tissues and recovery to normal height of the lower third of the face (vertical dimension occlusion), fixed a stable and balanced position of the lower jaw, and repaired the normal physiological position of the TMJ for the patient. Аfter a multi-stage treatment we received a result satisfying the patient, the dentist and the dental technician. Aesthetics and function were restored, and clinical symptoms were removed from the TMJ.
Goals, Constraints, and Transparently Fair Assignments: A Field Study of Randomization Design in the UEFA Champions League
Authors: Boczoń Marta , Wilson Alistair J. 
Published: September 2022

We analyze the design of a randomization procedure in a field setting with high stakes and substantial public interest: matching sports teams in the Union of European Football Association Champions League. While striving for fairness in the chosen lottery—giving teams similar distributions over potential partners—the designers seek to balance two conflicting forces: (i) imposing a series of combinatorially complex constraints on the feasible matches; and (ii) designing an easy-to-understand and credible randomization. We document the tournament’s solution, which focuses on sequences of uniform draws over each element in the final match, assisted by a computer to form the support for each draw. We first show that the constraints’ effects within this procedure are substantial, with shifts in expected prizes of up to a million euro and large distortions in match likelihoods of otherwise comparable team pairs. However, examining all possible counterfactual lotteries over the feasible assignments, we show that the generated inequalities are, for the most part, unavoidable and that the tournament design is close to a constrained-best. In two extensions, we outline how substantially fairer randomizations are possible when the constraints are weakened, and how the developed procedure can be adopted to more-general settings. This paper was accepted by Yan Chen, operations management. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2022.4528 .
Parents’ attitudes towards conversations with their young children about sex: A cross-sectional study
Authors: Jackson Jessica , Rhodes Christine , Kotera Yasuhiro 
Published: September 2022

Background: Parental confidence and attitudes towards a young child's readiness to receive sex education are varied and complex. There is growing global concern about increased sexual activity among younger children and related discussions about how families address sex education in the home. Aim: The purpose of this study was to identify determinants of parents’ communication about sex with their primary school-aged child/ren. Methods: The study employed a cross-sectional design for UK parents with at least one child aged 5–11 years using an online questionnaire which incorporated validated scales. Findings: A total of 205 parents participated with a total of 405 children. Parents with more than one child were more likely to have had a conversation with their child about sex and were more confident in talking about the reproductive process and healthy sexual relationships. Conclusions: Parents with the confidence to engage children in conversations about sex can support targeted risk behaviour, pubertal development and sexuality.
Analysis of heavy metal content and microbiological quality of fish and giant prawns chatch in Percut Watershed, Percut Sei Tuan District, Province of North Sumatra
Authors: Nasution Zulaika Haddis , Julianti Elisa , Suryanto Dwi 
Published: September 2022

The purpose of this research was to determine the content of heavy metals and microbiological quality, and compare to the requirements of the quality standard values according to SNI 2729:2013 and SNI 2705:2014, as well as to determine the value of the Bioaccumulation Factor (BAF) and the maximum consumption limit of fish and giant prawns heavy metal-concentrated. This researh used survey and random sampling methods, i.e taking research samples (tilapia, broom fish, and giant prawns) at 3 (three) observation stations, including Station 1 Amplas, Station 2 Denai, and Station 3 Percut. Heavy metal content (Pb and Cd) and microbiological quality (E.coli and Salmonella, sp) were analysed. Data analysis was done by inference and calculated using Microsoft office Excel (Microsoft Inc., USA) descriptively. The results showed that all samples in each observation did not meet the quality standard value requirements according to SNI 2729:2013 and SNI 2705:2014. The average heavy metal content of Lead (Pb) was 0,3 mg/kg in tilapia and broom fish, and 0,5 mg/kg in giant prawns. The content of heavy metal Cadmium (Cd), were 0,1 mg/kg in tilapia and broom fish, and 0,5 mg/kg in giant prawns. All samples also showed positive in containing E.coli and Salmonella, sp. The value of Bioaccumulation Factor (BAF) of heavy metals (Pb and Cd) in all samples was 1, meaning that the sample's ability to accumulate heavy metals (Pb and Cd) was high. The maximum limit for consumption of concentrated samples of heavy metals in tilapia was 0,196 kg/week, broom fish was 0,221 kg/week, and giant prawns was 0,203 kg/week.