bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nuclear basket protein ZC3HC1 and its yeast homolog Pml39p feature an evolutionary conserved bimodular construction essential for initial binding to NPC-anchored homologs of scaffold protein TPR
Authors: Gunkel Philip , Iino Haruki , Krull Sandra , Cordes Volker C. 
Published: September 2022

AbstractProteins ZC3HC1 and TPR are construction elements of the nuclear pore complex (NPC)-attached nuclear basket (NB). NB-location of ZC3HC1 depends on TPR already occurring NPC-anchored, whereas additional TPR polypeptides are appended to the NB by ZC3HC1. The current study examined the molecular properties of ZC3HC1 that enable it to bind to the NB and TPR. We report the identification and definition of a nuclear basket-interaction domain (NuBaID) ofHsZC3HC1 comprising two similarly built modules, both essential for the binding to the NB’s NPC-anchoredHsTPR. Furthermore, we describe such a bimodular construction as evolutionarily conserved and exemplify the kinship ofHsZC3HC1 by the NB- andDdTPR-interacting homolog ofDictyostelium discoideumand by characterizing protein Pml39 as the ZC3HC1 homolog inSaccharomyces cerevisiae. Among several properties shared by the different species’ homologs, we unveil the integrity of the bimodular NuBaID ofScPml39p as being essential for binding to the yeast’s NBs and its TPR homologsScMlp1p andScMlp2p, and we further present Pml39p as enabling interlinkage of Mlp1p subpopulations. In addition to phyla-specific features, we delineate the three species’ common NuBaID as the characterizing structural entity of a one-of-a-kind protein found not in all but likely most taxa of the eukaryotic realm.
Circadian and environmental signal integration in a natural population ofArabidopsis
Authors: Nishio Haruki , Cano-Ramirez Dora L. , Muranaka Tomoaki , de Barros Dantas Luíza Lane , Honjo Mie N. , Sugisaka Jiro , Kudoh Hiroshi , Dodd Antony N. 
Published: September 2022

AbstractPlants sense and respond to environmental cues during 24 h fluctuations in their environment. This requires the integration of internal cues such as circadian timing with environmental cues such as light and temperature to elicit cellular responses through signal transduction. However, the integration and transduction of circadian and environmental signals within plants growing in natural environments remains poorly understood. To gain insights into the 24 h dynamics of environmental signalling in nature, we performed a field study of signalling from the nucleus to chloroplasts in a natural population ofArabidopsis halleri.Using advanced modelling approaches to interpret the data, we identified that the circadian clock and temperature are key regulators of this pathway under natural conditions. We identified potential time-delay steps between pathway components, and diel fluctuations in the response of the pathway to temperature cues that are reminiscent of the process of circadian gating. This approach of combining studies of gene expression in the field with modelling allowed us to identify the dynamic integration and transduction of environmental cues, in plant cells, under naturally fluctuating diel cycles.
Development of the Centralized Interactive Phenomics Resource (CIPHER) Standard for Electronic Health Data-Based Phenomics Knowledgebase
Authors: Honerlaw Jacqueline , Ho Yuk-Lam , Fontin Francesca , Gosian Jeffrey , Maripuri Monika , Murray Michael , Sangar Rahul , Galloway Ashley , Zimolzak Andrew J. , Whitbourne Stacey B. , Casas Juan P. , Ramoni Rachel B. , Gagnon David R. , Cai Tianxi , Liao Katherine P. , Gaziano J. Michael , Muralidhar Sumitra , Cho Kelly 
Published: September 2022

ABSTRACTThe development of phenotypes using electronic health records is a resource intensive process. Therefore, the cataloging of phenotype algorithm metadata for reuse is critical to accelerate clinical research. The Department of Veterans Affairs Office of Research and Development has developed a phenomics knowledgebase library, CIPHER (Centralized Interactive Phenomics Research), which improves upon existing phenomics library models to help advance innovation in clinical research by using the CIPHER phenotype collection standard. The CIPHER standard was iteratively developed with phenomics experts and has been used to capture over 5,000 phenotypes. We describe the development of the CIPHER standard for phenotype metadata collection, its current application to the largest healthcare system in the United States, and the future expansion of the CIPHER knowledgebase as a public resource for phenotyping.
Structural insights into the elevator-type transport mechanism of a bacterial ZIP metal transporter
Authors: Zhang Yao , Jiang Yuhan , Gao Kaifu , Sui Dexin , Yu Peixuan , Su Min , Wei Guowei , Hu Jian 
Published: September 2022

AbstractThe Zrt-/Irt-like protein (ZIP) family consists of ubiquitously expressed divalent metal transporters critically involved in maintaining systemic and cellular homeostasis of zinc, iron, and manganese. Here, we present a study on a prokaryotic ZIP from Bordetella bronchiseptica (BbZIP) by combining structural biology, evolutionary covariance, computational modeling, and a variety of biochemical assays to tackle the issue of the transport mechanism which has not been established for the ZIP family. The apo state structure in an inward-facing conformation revealed a disassembled transport site, altered inter-helical interactions, and importantly, a rigid body movement of a 4-transmembrane helix (TM) bundle relative to the other TMs. The computationally generated and biochemically validated outward-facing conformation model revealed a slide of the 4-TM bundle, which carries the transport site(s), by approximately 8 Å toward the extracellular side against the static TMs which mediate dimerization. These findings allowed us to conclude that BbZIP is an elevator-type transporter.
Principles-based versus rules-based: accounting standards precision and financial restatements in China
Authors: Luo Shungen , Song Fei 
Published: September 2022

PurposeThis study tests the effect of accounting standards precision on financial restatements and the influence of accounting standards precision on different types of restatements (including errors and irregularities). What is more, the heterogeneity between accounting standards precision and financial restatements is verified in this paper. In the further analyses, the authors also examine the mediating roles and moderating roles on the correlation between accounting standards precision and financial restatements.Design/methodology/approachThe focus is placed on an unbalanced panel of 18,766 samples over the period of 2007–2017.FindingsThe authors find that firms' restatements decrease when standards are more principles-based (low accounting standards precision). Especially, irregularities significantly decrease when firms' standards are more principles-based. What's more, the negative relationship between principles-based standards and restatements is more significant in “big four” accounting firms. Moreover, from the mediating effect results, the authors find that low accounting standards precision decreases a firm's financial reporting complexity and increases equity restriction, which in turn can help decreasing its financial misreporting. From the moderating effect results, the authors find that the higher the TOP1 and the more analysts following the firm, the higher the benefit of accounting standards precision to misstatements.Originality/valueThe results of this study provide a theoretical reference for accounting standard setters and are helpful to inform investors and regulators about the influence of Chinese accounting standards on restatements.
Dispute root causes and prevention in Iranian public-private partnership projects: a causal-predictive model
Authors: Mirzaee Ali Mohammad , Pourrostam Towhid , Majrouhi Sardroud Javad , Hosseini M. Reza , Rahnamayiezekavat Payam , Edwards David 
Published: September 2022

PurposePublic–private partnerships (PPPs) are notoriously prone to disputes among stakeholders, some of which may unduly jeopardize contract performance. Contract disputes arising in Iran are often due to inefficiency of PPP concession agreements and practice. This study presents a causal-predictive model of the root causes and preventive measures for inter-organization disputes to enhance the likelihood of achieving desirable performance in PPP projects.Design/methodology/approachA theoretical “causal-predictive” model was developed with fourteen hypotheses based on extant literature and contractual agency theory, which resulted in the creation of a pool of 110 published items. Data were obtained from a questionnaire survey with 75 valid responses, completed by 4 stratified groups of Iranian PPP experts. Partial least square structural equation modeling (PLS-SEM) was used for validating the proposed model via a case study.FindingsResults reveal that the main three factors of PPP desirable performance are as follows: on-time project completion, high quality of activities/products and services for public satisfaction. Further, the most influential factors of the lifecycle problems, construction stage, and preferred risk allocation included risk misallocation, improper payment mechanism and failure to facilitate a timely approval process.Originality/valueFor researchers, the findings contribute to the theory of contractual agency; specifically, how different influences among the model's elements lead to better PPP performance. In practical terms, proposed outcome-based strategies will inform PPP stakeholders to avoid dispute occurrence and thus improve the time, quality and services of projects.
The PSICHE framework for sustainable consumption and future research directions
Authors: Nascimento Jorge , Loureiro Sandra Maria Correia 
Published: September 2022

PurposeConsidering the relevance of understanding what influences environmentally sustainable consumer choices, the present study aims to examine and synthesize the key determinants factors from literature and outline a new conceptual framework for explaining green purchasing behaviors (GPBs).Design/methodology/approachA bibliometric analysis was conducted on 161 articles extracted from Web of Science and Scopus databases, which were systematically evaluated and reviewed, and represent the current GPB knowledge base. Content analysis, science mapping and bibliometric analysis techniques were applied to uncover the major theories and constructs from the state-of-the-art.FindingsThe evolving debate between altruistic and self-interest consumer motivations reveals challenges for rational-based theories, as most empirical applications are not focused on buying behaviors, but instead either on pro-environmental (non-buying) activities or on buying intentions. From the subset of leading contributions and emerging topics, nine thematic clusters are unveiled in this investigation, which were combined to create the new PSICHE framework with the purpose of predicting GPB: (P)roduct-related factors, (S)ocial influences, (I)ndividual factors, (C)oncerns about the environment, (H)abits and (E)motions.Practical implicationsBy uncovering the multiple intervening factors in GPB decision processes, this study will assist practitioners and academics to move forward on how to foster more sustainable consumer behaviors.Originality/valueThe present study provides readers a summary of an unprecedentedly broad collection of papers, from which the key themes are categorized, the domain's intellectual structure is captured and an actionable framework for enhancing the understanding GPB is proposed. Four new thrust areas and a set of future research questions are included.
Higher education peacebuilding in conflict-affected societies: beyond the good/bad binary
Authors: Kester Kevin , Abura Mary , Sohn Chaewon , Rho Ella 
Published: September 2022

PurposeThis comparative case study looks towards the diverse approaches of higher education to support peacebuilding, from policy and philosophy to pedagogical practices, in conflict-affected and post-conflict settings. The achievement of global development goals is dependent on addressing access to quality education in conflict-affected contexts, including higher education. However, in settings affected by conflict, higher education is often perceived to be a luxury, not a necessity. This study, then, explores whether and how higher education might support peace and development through the unique perspective of the “three faces” of higher education in conflict contexts.Design/methodology/approachThe paper is designed as a qualitative comparative case study. The research examines the work of university educators in two institutions in Afghanistan and Somaliland, highlighting the challenges and opportunities they face working in conflict-affected societies and their pedagogical responses to conflict. Data for the research were collected through in-depth interviews, documents, and digital artifacts with 12 university educators across the two institutions. The faculty teach a wide variety of subjects in the social sciences and humanities, subjects including and in addition to those specific to peace and development studies. To strengthen the interpretation of data, multiple coders were involved and intercoder reliability was conducted.FindingsFindings indicate a number of challenges and opportunities that university lecturers and their institutions face in teaching for peace in conflict-affected contexts, particularly as it relates to the “three faces” of higher education to support, impede, or reveal the complicated nuances of peacebuilding in conflict settings. Member-checking was employed with participants to enhance the reliability of the analysis.Originality/valueIn the end, the paper contributes new empirical insights into higher education in conflict-affected contexts, particularly from the standpoint of faculty. Critical perspectives and implications for curriculum, pedagogy and research are offered.
Demographics, dwelling type and residents’ satisfaction at Zabdah affordable housing project, Jordan
Authors: Khassawneh Ebtesam M. , Khasawneh Fahed A. 
Published: September 2022

Purpose
This paper aims to study the Zabdah housing project residents’ satisfaction on both dwelling and neighborhood levels. In addition, the determinants of residents’ satisfaction are studied.

Design/methodology/approach
A mixed methodology approach was used, merging quantitative and qualitative methods. The questionnaire was developed and filled out through structured interviews. Descriptive statistics and multiple linear regression were used to understand the residents’ satisfaction levels. In addition, the chi-square test of independence was used to determine whether demographics and dwelling type were related to residents’ satisfaction.

Findings
It was found that the residents’ satisfaction level with Zabdah housing was moderate on both dwelling and neighborhood levels. On the dwelling level, the tiny dwelling areas were a fundamental problem. On the neighborhood level, good neighborhood services were crucial to the success of this project, while the lack of green spaces negatively affected the quality of life of its residents. In addition, the number of family members and dwelling types were critical determinants of residents’ satisfaction.

Practical implications
The findings can be developed into guidelines to govern the creation of better affordable residential environments. Furthermore, the successful dwelling typologies in this project can be modified to be adopted in the future.

Originality/value
To the best of the authors’ knowledge, this is the first study of its kind to explore the relationship of demographics and dwelling type with residents’ satisfaction in affordable housing in Jordan.
Work-related use of information and communication technologies after-hours (W_ICTs) and employee innovation behavior: a dual-path model
Authors: Huo Weiwei , Xu Xinyi , Li Xianmiao , Xie Julan , Sun Le 
Published: September 2022

PurposeThe current study aims to identify work-related use of information and communication technologies after-hours (W_ICTs) from passive and active perspectives and examine mechanisms and different effects of information and communication technologies on employee innovation behavior.Design/methodology/approachExperience sampling method (ESM) was employed to capture dynamic within-person variance in daily-behaviors and daily-mood. In total, 92 employees completed an identical online survey each day for ten workdays.FindingsThe findings showed that the influence patterns and mechanisms of passive and active W_ICTs were utterly different. Passive W_ICTs was negatively associated with employee innovation behavior via emotional exhaustion, while active W_ICTs was positively associated with employee innovation behavior through perceived insider status. Furthermore, differential leadership significantly narrowed the positive relationship between passive W_ICTs and emotional exhaustion. However, differential leadership did not significantly moderate the relationship between active W_ICTs and perceived insider status.Originality/valueThis study is an important step forward in dividing W_ICTs into passive and active W_ICTs and discovers a dual path of two types of W_ICTs on employee innovation behavior. Findings of this study have heuristic value for future research.
Financial inclusion and sustainable development: an empirical association
Authors: Ozili Peterson K. 
Published: September 2022

PurposeThis paper aims to investigate the association between financial inclusion and sustainable development in a global context.Design/methodology/approachThe study used two datasets, and employed the Pearson correlation analysis and granger causality test to examine the correlation and pairwise causality between financial inclusion and sustainable development.FindingsHigh levels of financial inclusion (in terms of higher commercial bank branches per 100,000 adults) is significantly associated with higher electricity production from renewable sources, higher industry productivity, higher adult literacy rate and higher renewable electricity output. Also, higher financial inclusion is significantly associated with low combustible renewables and waste. There is a uni-directional granger causality between global interest in internet information about sustainable development and global interest in internet information about financial inclusion, particularly in the period after the global financial crisis but before the COVID-19 pandemic.Practical implicationsThe correlation between financial inclusion and sustainable development depends on the indicators employed to measure financial inclusion and sustainable development. The results support global calls for greater financial inclusion and the speedy attainment of the sustainable development goals for the good of all people, the environment and for the planet.Originality/valueThis paper is the first study in the literature to analyze the link between financial inclusion and sustainable development using global data. This study contributes to the existing literature by investigating the association between financial inclusion and sustainable development in a global context.
The unemployment business: profit, precarity, and the moral economy of social democracy in Norway
Authors: McKowen Kelly 
Published: September 2022

AbstractNorway's welfare system is widely admired for its success in mitigating the worst effects of post‐industrial capitalism. In the past decade, however, that system has undergone remarkable – and controversial – change, as commercial firms have been permitted to play a growing role in administering services for the unemployed. This article, based on fieldwork in Oslo during the 2015‐16 oil crisis, examines Norway's ‘unemployment business’ and the high‐stakes symbolic struggle between its advocates and opponents. It shows that making unemployment services a business not only destabilizes the unique moral economy of social democracy, predicated on the conceptual entwinement of the state and society, but also requires the maintenance of a new class of precarious workers who administer the welfare system without having its guarantees. Beyond its Norwegian concerns, this article also refines our understanding of moral economy and privatization through highlighting the strategies actors deploy to endow new economic activities with moral legitimacy.
THE STATE OF THE CIRCULAR ECONOMY: Waste Valorization in Hong Kong and Rotterdam
Authors: Wildeboer Viktor , Savini Federico 
Published: September 2022

AbstractThe concept of the circular economy has gained significant political momentum because it offers policymakers a viable approach to tackling resource depletion, reducing waste and promoting economic development all at the same time. Current research, however, only focuses on the technological feasibility of this model, overlooking circularity's inherent contradiction: namely, that it valorizes waste rather than reducing it. This article tackles this limit by questioning the role of the state in what we describe as ‘waste valorization’. It interrogates the urban political ecology of construction and demolition waste, the largest stream of inert materials in the world. It analyses CDW's geographies and economic position in urban development and the shifting rationales by which it is governed. To do this, it compares historical shifts in how CDW has been regulated in Hong Kong and Rotterdam. The article shows that waste is no longer an abject residual of urbanization, but a driver of urban development and a burgeoning sphere of accumulation in ecological capitalism.
An Assessment of Potential Severe Droughts in the Colorado River Basin
Authors: Salehabadi Homa , Tarboton David G. , Udall Bradley , Wheeler Kevin G. , Schmidt John C. 
Published: September 2022

ABSTRACTMuch has been learned about Colorado River hydrology since the severe sustained drought study in 1995. We summarize our updated understanding of plausible future drought conditions by considering historical flows, tree‐ring reconstructions, and climate change. We focus on natural streamflow at Lees Ferry, the primary metric used to quantify the runoff in the Colorado River Basin. We identify drought periods using historical records and tree‐ring reconstructed streamflow at Lees Ferry, which we then use to characterize potential future droughts. Resampling from past drought periods generates plausible future conditions to consider during planning. We produced three drought scenarios, each comprising 100 streamflow sequences to be used as input to systems operation and management models. We used analysis of the duration‐severity and cumulative deficit relative to the mean natural flow to evaluate droughts and drought simulations and show that the current millennium drought that started in 2000 has an average flow far less than the historical record. However, the flows reconstructed from tree rings or future flows projected from climate models indicate that even more severe droughts are possible. When used as input to the Colorado River Simulation System the drought scenarios developed indicate considerable periods when Lake Powell falls below its hydropower penstocks, indicating a need to rethink management and operation of these reservoirs during these critical conditions.