bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multicenter study of the evolution of different types of avulsion over the 12 months after delivery
Authors: García‐Mejido José Antonio , González‐Diaz Enrique , Ortega Ismael , Martín‐Martinez Alicia , Fernández‐Palacín Ana , Sainz‐Bueno José Antonio 
Published: April 2022

AbstractObjectiveTo perform a multicenter study of muscle recovery in levator ani muscle (LAM) avulsion during the first 12 months postpartum according to the type of LAM avulsion suffered.MethodsThis was a multicenter prospective observational study including 242 primiparas. Transperineal ultrasound was performed at 6 months and 12 months after delivery. Type I LAM avulsion was present when most of the lateral fibers of the pubovisceral muscle were observed at the muscle's insertion at the pubic level. Type II LAM avulsion was defined as complete detachment of the pubovisceral muscle from its insertion at the pubic level.ResultsAmong the 56 patients who completed the study (with ultrasound at 6 and 12 months after delivery), 76 avulsions (10 cases of bilateral avulsion) were identified at 6 months after delivery, and the total number of avulsions had decreased to 58 at 12 months after delivery (P < 0.001; 95% confidence interval [CI] 13.9%–33.5%). This decrease was due to the disappearance of 69.2% of the cases of Type I LAM avulsions (P < 0.001; 95% CI: 50.2%–88.2%). However, the number of Type II LAM avulsions remained constant at 6 months and 12 months after delivery.ConclusionThe spontaneous resolution of LAM avulsion during the first 12 months postpartum occurs in cases of Type I LAM avulsion but is not observed in Type II LAM avulsion.
Front Cover
Authors: Feng Ximeng , Yu Yue , Zou Da , Jin Zi , Zhou Chuanqing , Liu Gangjun , Fujimoto James G. , Li Changhui , Lu Yanye , Ren Qiushi 
Published: April 2022

A novel integration of retinal multispectral imaging (MSI), retinal oximetry, and laser speckle contrast imaging (LSCI) is presented for functional imaging of retinal blood vessels that could potentially allow early detection or monitoring of functional changes. This technology can rapidly acquire structural MSI images, retinal oximetry, and LSCI blood flow information in a simplified clinical workflow. Results from multiple modalities can be combined to provide structural‐functional information.Further details can be found in the article by Ximeng Feng, Yue Yu, Da Zou, Zi Jin, Chuanqing Zhou, Gangjun Liu, James G. Fujimoto, Changhui Li, Yanye Lu, Qiushi Ren (e202100285)
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Renal Clearance of Fibroblast Growth Factor-23 (FGF23) and its Fragments in Humans
Authors: Sharma Shilpa , Katz Ronit , Ginsberg Charles , Bullen Alexander , Vallon Volker , Thomson Scott , Moe Orson W. , Hoofnagle Andrew N. , de Leeuw Peter W. , Kroon Abraham A. , Houben Alfons J.H.M. , Ix Joachim H. 
Published: April 2022

ABSTRACT
Relative abundance of fibroblast growth factor-23 (FGF23) measured by the C-terminal (cFGF23, which measures both intact FGF23 and C-terminal fragments) versus intact (iFGF23, measures only intact hormone) assays varies by kidney function in humans. Differential kidney clearance may explain this finding. We measured cFGF23 and iFGF23 in the aorta and bilateral renal veins of 162 patients with essential hypertension undergoing renal angiography. Using multivariable linear regression, we examined factors associated with aorta to renal vein reduction of FGF23 using both assays. Similar parameters and with addition of urine concentrations of cFGF23 and iFGF23 were measured in six Wistar rats. Mean ± standard deviation (SD) age was 54 ± 12 years, 54% were women, and mean creatinine clearance was 72 ± 48 mL/min/100 g. The human kidney reduced the concentrations of both cFGF23 (16% ± 12%) and iFGF23 (21% ± 16%), but reduction was higher for iFGF23. Greater kidney creatinine and PTH reductions were each independently associated with greater reductions of both cFGF23 and iFGF23. The greater kidney reduction of iFGF23 compared to cFGF23 appeared stable and consistent across the range of creatinine clearance evaluated. Kidney clearance was similar, and urine concentrations of both assays were low in the rat models, suggesting kidney metabolism of both cFGF23 and iFGF23. Renal reduction of iFGF23 is higher than that of creatinine and cFGF23. Our data suggest that FGF23 is metabolized by the kidney. However, the major cell types involved in metabolization of FGF23 requires future study. Kidney clearance of FGF23 does not explain differences in C-terminal and intact moieties across the range of kidney function. © 2022 American Society for Bone and Mineral Research (ASBMR).
Synthesis and molecular modeling of new 2‐benzylidenethiobarbituric acid derivatives as potent tyrosinase inhibitors agents
Authors: Najafi Zahra , Kamari‐aliabadi Adel , Sabourian Reyhaneh , Hajimahmoodi Mannan , Chehardoli Gholamabbas 
Published: April 2022

AbstractNew 2‐benzylidenethiobarbituric acid‐(benzyloxyphenyl) derivatives were designed, synthesized, and evaluated as tyrosinase inhibitors. The products can be divided into two groups: 4‐hydroxybenzaldehyde derivatives and vanillin derivatives. Some of the 4‐hydroxybenzaldehyde derivatives showed significant inhibitory activity while all vanillin derivatives have no inhibitory activities. It seems that the presence of the methoxy group on the internal aromatic ring prevents the ligand–enzyme interaction. According to the tyrosinase inhibitory assay, 5‐(4‐([4‐Methylbenzyl]oxy)benzylidene)‐2‐thioxodihydropyrimidine‐4,6(1H,5H)‐dione (4g) is the most potent antityrosinase agents with an IC50 value of 23.90 ± 0.08 μM. It showed even better inhibitory activity than kojic acid. The results of kinetic and molecular docking studies demonstrated that compound 4g acts as a noncompetitive inhibitor and can bind to some amino acids such as His263 and Val283 of the active site through Pi–alkyl and Pi–Pi interactions and areas around the active site via the hydrogen bond. In‐silico adsorption, distribution, metabolism, excretion, and toxicity (ADMET) studies predicted that these products have good drug‐likeness. All findings indicate the 2‐benzylidenethiobarbituric acids with the benzyloxyphenyl tail have good potential for the treatment of melanogenesis compared to kojic acid.
Authentication of documents using polypropylene immobilized with rare‐earth doped aluminate nanoparticles
Authors: Al‐Qahtani Salhah D. , Snari Razan M. , Alkhamis Kholood , Alhasani Mona , Ibarhiam Saham F. , Habeebullah Turki M. , El‐Metwaly Nashwa M. 
Published: April 2022

AbstractAnticounterfeiting of commercial products has been improved using photochromism as an intriguing approach. In order to develop a mechanically reliable nanocomposite, the engineering procedure of the anticounterfeiting nanocomposite must be improved. Rare‐earth doped aluminate/polypropylene (REA/PP) hybrid nanofibers were successfully made by electrospinning, and they were shown to be mechanically stable and highly photoluminescent, making them ideal for anticounterfeiting applications. UV‐induced photochromic anticounterfeiting properties were monitored in the synthesized nanocomposite films. In order to ensure that the REA‐PP film is completely transparent, REA must be embedded into the polypropylene nanofibers in nano‐sized particle shape to facilitate a better dispersion without agglomeration of REA particles in polypropylene matrix. The morphology and structure of REA were studied by transmission electron microscopy and X‐ray diffraction. The morphologies and chemical contents of the polypropylene nanofibrous films were studied by scanning electron microscopy, X‐ray fluorescence, and energy‐dispersive X‐ray spectroscopy. The REA‐PP nanofibrous film showed absorbance and emission maxima at 365 and 517 nm, respectively. When exposed to UV light, the photochromic activity of the transparent nanofibrous substrates to greenish‐yellow was rapid and reversible without fatigue. Hydrophobicity of REA‐PP films increased without affecting their original look or mechanical properties, while increasing the REA content. It was possible to produce ultraviolet‐induced photochromic nanofibrous films that were transparent, flexible, and cost‐effective. As a result of this method, numerous anticounterfeiting materials could be developed toward a better marketplace with both economy and community values.Highlights
Rare‐earth aluminate/polypropylene (REA/PP) electrospun nanofibers were prepared.
The photochromic transparent nanofibers displayed green emission under UV light.
The nanofibrous films were flexible, mechanically stable and highly luminescent.
Films showed absorbance and emission maxima at 365 and 517 nm, respectively.
Hydrophobicity was improved without affecting the films original properties.
Data switching method among heterogeneous power information system databases based on knowledge graph
Authors: Bao Fu , Tian Yuan , Gao Yudou 
Published: April 2022

AbstractIn order to solve the problems of long data switching time, low information utilization rate, and low switching accuracy in traditional data switching methods, a data switching method between heterogeneous power information system databases based on knowledge graphs is proposed. Based on the knowledge graph technology and its ternary structure, the data of the heterogeneous power information system is processed, and the N‐Gram model is used to realize the knowledge extraction, and the data error correction is established through the model. Through ODBC technology to complete the link between heterogeneous power information system databases, and then select the data access interface and determine the data extraction task, and finally realize the data exchange between the heterogeneous power information system databases. Experimental results show that the average communication channel bandwidth during the data switching process is 1.8 Gb/s, the highest value of data switching accuracy reaches 82%, and the information utilization rate after data switching is relatively high, indicating that the method has certain effectiveness.
Equivalent‐circuit extraction for gallium nitride electron devices: Direct versus optimization‐empowered approaches
Authors: Jarndal Anwar , Crupi Giovanni , Alim Mohammad Abdul , Vadalà Valeria , Raffo Antonio , Vannini Giorgio 
Published: April 2022

AbstractThis work focuses on the equivalent‐circuit modeling of microwave field‐effect transistors. Although the purely direct approach allows obtaining a good prediction accuracy in a straightforward way without the need of any optimization, optimization algorithms are often used to achieve an improved accuracy at the cost of a higher modeling complexity. The pros and cons of empowering the direct approach with optimization algorithms are discussed by focusing the analysis on a 1000‐μm periphery gallium nitride high‐electron‐mobility transistor on silicon carbide substrate. The comparison between the two different approaches is performed through an extensive analysis of the frequency‐dependent behavior of the small‐signal characteristics.
How do snow cover fraction change and respond to climate in Altai Mountains of China?
Authors: Qin Shen , Xiao Pengfeng , Zhang Xueliang 
Published: April 2022

AbstractInvestigating the spatial and temporal changes in snow cover over mountain areas is significant for understanding the impact of regional climate variability. In this study, using cloud‐removed snow cover data, which are generated based on Moderate Resolution Imaging Spectroradiometer (MODIS) daily snow cover products, the spatiotemporal changes of snow cover fraction (SCF) and its relationship with temperature and precipitation changes from 2002 to 2020 were examined over Altai Mountains, China. The results demonstrate that the distribution and changes of SCF are highly spatiotemporally heterogeneous. Within a year, the maximum SCF occurs in January at 98.6%, and the minimum appears in July at 8.7%. The annual‐mean SCF shows an increasing trend at 0.09%·annum−1, owing to the significantly increasing SCF in the snow accumulation period at 0.5%·annum−1 and the decreasing SCF in the snow melting period at −0.2%·annum−1. The SCF distribution, as well as its interannual change, is greatly influenced by elevation. During the snow cover period, a positive linear correlation between SCF and elevation is found at 0.02%·m−1 (p < .01). The annual‐mean SCF decreases in the area below 1,200 m, whereas it increases in the area above 1,200 m. Accordingly, the elevation‐dependent SCF results in various SCF distributions on different slopes and watersheds. The SCF shows an apparent pattern in different aspects, with similar SCFs between the north and east aspects and between the west and south aspects but a difference between the northeast aspects and the westsouth aspects. The SCF is negatively correlated with air temperature (r = −0.74, p < 0.01) and positively correlated with precipitation (r = 0.74, p < 0.01). In addition, temperature shows a significant and larger correlation with SCF in both the snow accumulation and melting periods, indicating the major factor of temperature for the changes in SCF.
A unique approach to achieving organizational excellence: The Cube One Framework
Authors: Kopelman Richard E. 
Published: April 2022

AbstractIn this article, I present the rationale and evidence pertinent to the utility of the Cube One Framework for achieving organizational excellence. Three factors contribute to the uniqueness of the Cube One framework: (1) the reliance on measuring the frequency of enacted practices (as contrasted to the traditional emphasis on stated policies, leadership philosophies, and mission statements); (2) the empirical examination of practices directed toward satisfying the needs of three separate stakeholders—funders, customers, and employees–customers consistently being neglected from lists of High‐Performance Work Practices which focus solely on productivity and employee satisfaction; and (3) the capability of performing an empirically‐based diagnosis of organizational strengths and opportunities for improvement. I offer three types of evidence: survey data collected in four studies conducted in three countries–where results are (surprisingly) slightly stronger for organizations in the nonprofit/government sectors as compared to for‐profit companies; longitudinal stock market valuations using a sample of America's Most Admired Companies per Fortune Magazine; and seven case studies of prominent organizations such as Google, Four Seasons Hotels, and Mayo Clinic.
Towards a solid‐state light detection and ranging system using holographic illumination and time‐of‐flight image sensing
Authors: Bantounos Konstantinos , Smeeton Tim M. , Underwood Ian 
Published: April 2022

AbstractLight detection and ranging (LIDAR) systems are finding their way into an increasing number of applications including autonomous vehicles. Image sensors based on single‐photon avalanche diode (SPAD) arrays have demonstrated great promise for LIDAR, typically using flood illumination or raster‐scanning of a small spot. Holographic illumination, based on phase‐only liquid crystal on silicon (LCoS) spatial light modulators, has been successfully applied to display systems such as automotive head up displays (HUDs). It holds great promise as the method of illumination for a LIDAR system. We present a novel solid‐state LIDAR architecture using holographic projection and single‐photon detection. We report a simple experiment that demonstrates proof of concept. The results of the experiment show that the novel architecture can improve the depth accuracy of 3D imaging compared to conventional LIDAR systems. We also indicate several key performance advantages of the novel architecture that will increase as the system scales to higher performance.
Seasonal dynamics of anaerobic oxidation of ammonium and denitrification in a dimictic lake during the stratified spring–summer period
Authors: Alejandra Peña Sanchez , Clara Duffner , Anja Wunderlich , Bernhard Mayer , Stefanie Schulz , Schloter Michael , Florian Einsiedl 
Published: April 2022

AbstractIn aquatic ecosystems, nitrogen (N) loading is mitigated in redox transition zones principally through the processes of denitrification and anaerobic oxidation of ammonium (anammox). Here, we investigate the N cycling processes in the water column of a seasonal stratified lake influenced by benthic processes in Southern Germany (Fohnsee) during the development of the vertical redox stratification between April and September. Concentration profiles and stable isotope compositions of NO3− and NH4+ together with numerical modeling and quantification of the hydrazine synthase gene (hzsB) and nitrite reductase (nirK and nirS) genes were used to identify the predominant nitrogen‐transformation processes at lake Fohnsee throughout the spring and summer periods. Water chemistry data, quantitative polymerase chain reaction analysis and increases of δ15N and δ18O values of nitrate from 7.0‰ to 41.0‰ and 2.0‰ to 28.0‰, respectively, showed that nitrate reduction to nitrite and NO occurs in an upward moving zone of the water column from June to September following the displacement of the oxycline caused by thermal stratification. We also observed an increase in δ15N of ammonium from 15‰ to 28‰ in the anoxic water column. Modeling results suggest that this shift in δ15N‐NH4+ is predominantly controlled by mixing between ammonium stemming from the oxic water column with δ15N values of 25‰ and ammonium that is likely formed in the lake sediments by oxidation of organic matter with δ15N values of 11‰. Observed gene abundances (hzsB, nirK, and nirS) in lake water samples collected in June and July indicated the co‐occurrence of nitrate reduction and low rates of anammox, while the presence of sulfide in August and September may have inhibited the activity of anammox bacteria near the sulfate‐reduction zone at the lake bottom. This study revealed temporal and spatial (e.g., depth dependent) variations in the dominant N‐transformation processes in the investigated lake.
The theory of hereditarily bounded sets
Authors: Jeřábek Emil 
Published: April 2022

AbstractWe show that for any , the structure of sets that are hereditarily of size at most k is decidable. We provide a transparent complete axiomatization of its theory, a quantifier elimination result, and tight bounds on its computational complexity. This stands in stark contrast to the structure of hereditarily finite sets, which is well known to be bi‐interpretable with the standard model of arithmetic .
The Schwarz alternating method for transient solid dynamics
Authors: Mota Alejandro , Tezaur Irina , Phlipot Gregory 
Published: April 2022

AbstractIn our earlier work, we formulated the Schwarz alternating method as a means for concurrent multiscale coupling in finite deformation solid mechanics for quasi‐static problems. Herein, we advance this method for the study of transient dynamic multiscale solid mechanics problems where information is exchanged back and forth between small and large scales. The extension to dynamics relies on the notion of a global time stepper. Within each global time step, the subdomains are coupled by the standard Schwarz iterative process. Remarkably, each subdomain can use its own time step or even its own time integrator to advance its solution in time, provided that they synchronize at each global time step. We study the performance of the Schwarz method on several examples designed for this purpose. Our numerical experiments demonstrate that the method is capable of coupling regions with different mesh resolutions, different element types, and different time integration schemes (e.g., implicit and explicit), all without introducing any artifacts that afflict other coupling methods for transient dynamics. Finally, we apply the dynamic Schwarz alternating method to the simulation of a bolted joint subjected to dynamic loading, as a demonstration of the performance of the method in a realistic scenario.
COVID‐19 vaccine (mRNA BNT162b2) and COVID‐19 infection‐induced thrombotic thrombocytopenic purpura in adolescents
Authors: Vorster Luna , Kirk Susan E. , Muscal Eyal , Despotovic Jenny M. , Cohen Clay T. , Sartain Sarah E. 
Published: April 2022

AbstractThe mRNA COVID‐19 vaccine and COVID‐19 infection caused by the SARS‐CoV‐2 virus may be immunologic triggers for the development of thrombotic thrombocytopenic purpura (TTP). There is not yet literature that discusses TTP induced by COVID‐19 vaccination or infection in pediatric or adolescent patients. We describe three adolescents presenting with TTP (both de novo and relapsed disease) following administration of the Pfizer COVID‐19 vaccine or after COVID‐19 infection. Our observations demonstrate that the Pfizer‐BioNTech mRNA vaccine and COVID‐19 infection can act as triggers for the development/relapse of both congenital and acquired TTP.
Low‐dose ketamine infusions reduce opioid use in pediatric and young adult oncology patients
Authors: Anghelescu Doralina L , Ryan Stephanie , Wu Diana , Morgan Kyle J. , Patni Tushar , Li Yimei 
Published: April 2022

AbstractBackgroundKetamine is an NMDA‐receptor antagonist with analgesic and opioid‐sparing properties. Although well studied in adults, more robust evidence supporting ketamine's use for pediatric pain management is needed. This retrospective study evaluates ketamine's opioid‐sparing effectiveness in pediatric and young adult oncology and hematology patients.ProcedureContinuous ketamine infusions administered for pain management between 2010–2020 were reviewed. Data including demographic characteristics, oncology/hematology and pain diagnoses, concurrent pain medications, and ketamine infusions’ dose and duration were collected. Opioid consumption data based on delivery via patient‐controlled analgesia were collected 1 day before (D1), all days during (cumulatively named D2), and 1 day after (D3) ketamine infusions and calculated as morphine‐equivalent doses (mg/kg/day). Data were reported for the entire study group as well as for distinct oncology and end‐of‐life categories, and short‐term acute pain circumstances which included vaso‐occlusive crises in hematology patients. Side effects were reviewed.ResultsSignificantly lower daily opioid consumption was noted in the oncology group, while decreases were not significant in the end‐of‐life group and in the overall study population. The acute pain group did not show an opioid reduction associated with the ketamine infusions. A largely tolerable side‐effect profile was observed, with no differences among each group's incidence.ConclusionsKetamine infusions were associated with significantly reduced opioid consumption for oncology patients. The opioid‐sparing effects of ketamine may vary according to clinical diagnoses and circumstances of use. Overall, low‐dose ketamine infusions present an acceptable safety profile in pediatric and young adult patients; nevertheless, individual risks and benefits should be considered.