bluuebunny/crossref_metadata_2025_split huggingface dataset:
Round and flat zygomatic implants: effectiveness after a 1-year follow-up non-interventional study
Authors: Aparicio Carlos , Polido Waldemar D. , Chow James , Davó Rubén , Al-Nawas Bilal 
Published: April 2022

Abstract
Introduction
There are few zygomatic implants (ZI) designs available. The objective of this non-interventional study was to report the effectiveness of two new site-specific ZI, selected and placed following the zygoma anatomy-guided approach (ZAGA).

Materials and methods
Consecutive patients presenting indications for rehabilitation using ZI were treated according to ZAGA Concept recommendations. Implants were immediately loaded following the manufacturer’s instructions. Success criteria regarding prosthetic offset, rhino-sinus status, soft tissue condition, and implant stability were additionally used as outcome parameters.

Results
Twenty patients were followed for a period of 12 to 28 months (average 18.8 months). Ten received 2 ZI plus regular anterior implants; One received 3 ZI plus regular implants and nine received 4 ZI. In total, 59 ZI were placed, 34 (58%) Straumann ZAGA-Flat design, and 25 (42%) ZAGA-Round. Forty-nine percent of the sites were classified as ZAGA-4 type and 27% as ZAGA-2. Four patients (20%) presented discontinuities of the sinus–nose floor before surgery and 15 patients (75%) presented previous sinus opacities. All implants bar one reached more than 45 N.cm of insertion torque. No surgical complications were observed. After 1 year, the modified Lund–Mackay score was negative in 17 patients. Seventeen sites in 11 patients exhibited decreased opacity when pre-surgical imaging was compared to 1-year post-surgical CBCT. All implants and prostheses remained stable and in function.

Conclusions
The study concluded 100% implant/prosthesis survival rates and low complication levels. Within the limitations of the sample and observation period, results suggest that even in cases of extremely resorbed maxillae (as per cases in this study), ZAGA-Flat and ZAGA-Round ZI are viable treatment options when restoring atrophic maxillae following the ZAGA protocol.
Successful conversion surgery for stage IV gastric cancer with liver metastases after second-line chemotherapy with ramucirumab and paclitaxel: a case report
Authors: Fukuda Kosuke , Arigami Takaaki , Tokuda Koki , Yanagita Shigehiro , Matsushita Daisuke , Kawasaki Yota , Iino Satoshi , Sasaki Ken , Nakajo Akihiro , Kirishima Mari , Tanimoto Akihide , Tsubouchi Hitoshi , Kurahara Hiroshi , Ohtsuka Takao 
Published: April 2022

Abstract
Background
In recent years, conversion surgery after chemotherapy has been considered a promising strategy for improving the prognosis of patients with stage IV gastric cancer. However, there are few reports on conversion gastrectomy after second-line chemotherapy. Here, we report a case of long-term survival of a patient with liver metastases from gastric cancer who underwent conversion surgery after second-line chemotherapy with ramucirumab and paclitaxel.

Case presentation
A 77-year-old man complaining of weight loss was diagnosed with human epidermal growth factor receptor 2-positive gastric cancer with multiple liver metastases. Although the patient initially received trastuzumab-based chemotherapy, it was discontinued, because he experienced trastuzumab-induced infusion reactions. Thereafter, he was treated with six courses of S-1 plus cisplatin and six courses of ramucirumab plus paclitaxel as the first- and second-line regimens, respectively. The primary tumor and liver metastases remarkably shrank, and the reduction rate of the measurable metastatic liver lesions was 81.1%. According to the Response Evaluation Criteria in Solid Tumors, the patient responded partially. Therefore, he underwent total gastrectomy with D2 lymphadenectomy and partial hepatectomy of segments 3 and 4. Pathological examination revealed tumor invasion into the muscularis propria, a grade 1a histological response, and no lymph node metastases. No viable cancer cells were identified in the specimens resected from liver segments 3 and 4. Accordingly, the patient was pathologically diagnosed with stage IB (ypT2N0M0). Postoperatively, the patient received adjuvant chemotherapy with S-1 for 6 months, and he survived without recurrence for 42 months after conversion surgery.

Conclusions
Conversion surgery might be clinically useful for improving survival in certain patients with gastric cancer, including those who previously received second-line chemotherapy.
The Training Characteristics of World-Class Distance Runners: An Integration of Scientific Literature and Results-Proven Practice
Authors: Haugen Thomas , Sandbakk Øyvind , Seiler Stephen , Tønnessen Espen 
Published: April 2022

AbstractIn this review we integrate the scientific literature and results-proven practice and outline a novel framework for understanding the training and development of elite long-distance performance. Herein, we describe how fundamental training characteristics and well-known training principles are applied. World-leading track runners (i.e., 5000 and 10,000 m) and marathon specialists participate in 9 ± 3 and 6 ± 2 (mean ± SD) annual competitions, respectively. The weekly running distance in the mid-preparation period is in the range 160–220 km for marathoners and 130–190 km for track runners. These differences are mainly explained by more running kilometers on each session for marathon runners. Both groups perform 11–14 sessions per week, and ≥ 80% of the total running volume is performed at low intensity throughout the training year. The training intensity distribution vary across mesocycles and differ between marathon and track runners, but common for both groups is that volume of race-pace running increases as the main competition approaches. The tapering process starts 7–10 days prior to the main competition. While the African runners live and train at high altitude (2000–2500 m above sea level) most of the year, most lowland athletes apply relatively long altitude camps during the preparation period. Overall, this review offers unique insights into the training characteristics of world-class distance runners by integrating scientific literature and results-proven practice, providing a point of departure for future studies related to the training and development in the Olympic long-distance events.
Clinical characteristics of renal transplant recipients who developed de novo donor-specific antigen in Kyoto University Hospital: a case series
Authors: Nakamura Kenji , Sawada Atsuro , Kita Yuki , Kono Jin , Masui Kimihiko , Sato Takuma , Sano Takeshi , Goto Takayuki , Akamatsu Shusuke , Ogawa Osamu , Kobayashi Takashi 
Published: April 2022

Abstract
Background
The clinical significance of de novo donor-specific antigen (DSA) in renal transplant recipients is not yet fully understood. This study aimed to report the prevalence of de novo DSA detected in antihuman leukocyte antigen (HLA) antibody testing and to evaluate the association between de novo DSA and renal transplant prognosis in living-donor renal transplant recipients at our hospital.

Methods
Of the 110 patients who underwent living-donor renal transplantation from 1980 to 2019, 80 patients who underwent anti-HLA antibody screening tests were retrospectively reviewed for the development of de novo DSA and outcomes regarding graft function.

Results
The mean age at transplantation was 43.2 ± 14.6 years. Of the 80 patients, 43 (53.8%) were men and 68 (85.0%) underwent ABO-compatible transplantation. Anti-HLA antibody was detected in 14 patients (17.5%), including eight (10.0%) with de novo DSA. Graft loss occurred in two (25%) of the eight patients with de novo DSA, none of the six patients with non-DSA anti-HLA antibody and no anti-HLA antibody (P = 0.0419, log-rank test). The mean estimated glomerular filtration rate at the time of the anti-HLA antibody test was 45.1 ± 14.4 mL/min/1.73m2 in the 66 patients with no anti-HLA antibody, while it was 35.0 ± 11.5 mL/min/1.73m2 in the eight patients with de novo DSA (P = 0.0702) and 39.3 ± 15.3 mL/min/1.73m2 in the six patients with non-DSA anti-HLA antibody (P = 0.3921). The mean monthly cyclosporin A trough concentration for the past year from the anti-HLA antibody test was 59.2 ± 24.8 ng/ml in the seven patients with no anti-HLA antibody, while it was 61.9 ± 12.5 ng/ml in the five patients with de novo DSA (P = 0.5670) and 36.3 ± 9.0 ng/ml in a patient with non-DSA anti-HLA antibody (P = 0.3921). The mean monthly tacrolimus trough concentration for the past year from the anti-HLA antibody test was 4.62 ± 1.20 ng/ml in the 55 patients with no anti-HLA antibody, while it was 4.09 ± 1.10 ng/ml in the three patients with de novo DSA (P = 0.0027) and 4.21 ± 1.14 ng/ml in the four patients with non-DSA anti-HLA antibody (P = 0.0722).

Conclusions
The optimal treatment for patients with de novo DSA has not been established, and immunosuppressive management that suppresses the development of de novo DSA is essential.
Imported malaria in adults: about a case of cerebral malaria
Authors: Ben Abderrahim Sarra , Gharsallaoui Sarra , Ben Daly Amal , Mosbahi Amal , Chaieb Selma , Nfikha Zeineb , Ismaïl Samar , Makni Chahnez , Mokni Moncef , Fathallah-Mili Akila , Jedidi Maher , Ben Dhiab Mohamed 
Published: April 2022

Abstract
Background
Malaria is the first parasitic infection endemic in the world caused by parasites species of Plasmodium. Cerebral malaria (CM) is a rapidly progressive and severe form of Plasmodium falciparum infection, characterized by a greater accumulation of red blood cells parasitized by Plasmodium falciparum in the brain. The diagnosis of malaria is usually made in living patients from a blood sample taken in the course of a fever on return from an endemic country, whereas CM, often associated with fatal outcomes even in treated subjects, is usually diagnosed at autopsy.

Case presentation
We present the case of a 36-year-old man who died a few days after returning from a business trip to the Ivory Coast. As a result of an unclear cause of death, a medicolegal autopsy was ordered. Autopsy findings revealed massive congestion and edema of the brain with no other macroscopic abnormalities at organ gross examination. Histology and laboratory tests were conducted revealing a Plasmodium falciparum infection, with numerous parasitized erythrocytes containing dots of hemozoin pigment (malaria pigment) in all examined brain sections and all other organs. Death was attributed to cerebral malaria with multiple organ failure.

Conclusions
This report summarizes several features for the diagnosis of malaria and how postmortem investigations, as well as histology and laboratory diagnosis, may lead to a retrospective diagnosis of a fatal complicated form with cerebral involvement.
Isolated pneumomediastinum in severe category COVID-19 patients admitted in ICU: a case series
Authors: Nazir Nazia , Saxena Anupriya 
Published: April 2022

Abstract
Background
Pneumomediastinum is a rare complication associated with acute respiratory distress syndrome secondary to other viral pneumonias. However, it has been on a rise in COVID-19 patients with severe disease.

Case presentation
We present three cases to highlight that isolated pneumomediastinum can complicate the course of illness in patients on non-invasive ventilation. In our case series, two COVID-19 diagnosed cases with no previous history of intubation developed pneumomediastinum. They were managed conservatively with a successful outcome. The third patient developed PM with subcutaneous emphysema post-intubation, although managed conservatively succumbed to the disease.

Conclusions
Clinicians need to be alert to the development of such a complication in the event of sudden onset dyspnoea with chest pain. Conservative management, with low pressure settings on the ventilator results in gradual improvement of patient.
Machine learning techniques for arrhythmic risk stratification: a review of the literature
Authors: Chung Cheuk To , Bazoukis George , Lee Sharen , Liu Ying , Liu Tong , Letsas Konstantinos P. , Armoundas Antonis A. , Tse Gary 
Published: April 2022

AbstractVentricular arrhythmias (VAs) and sudden cardiac death (SCD) are significant adverse events that affect the morbidity and mortality of both the general population and patients with predisposing cardiovascular risk factors. Currently, conventional disease-specific scores are used for risk stratification purposes. However, these risk scores have several limitations, including variations among validation cohorts, the inclusion of a limited number of predictors while omitting important variables, as well as hidden relationships between predictors. Machine learning (ML) techniques are based on algorithms that describe intervariable relationships. Recent studies have implemented ML techniques to construct models for the prediction of fatal VAs. However, the application of ML study findings is limited by the absence of established frameworks for its implementation, in addition to clinicians’ unfamiliarity with ML techniques. This review, therefore, aims to provide an accessible and easy-to-understand summary of the existing evidence about the use of ML techniques in the prediction of VAs. Our findings suggest that ML algorithms improve arrhythmic prediction performance in different clinical settings. However, it should be emphasized that prospective studies comparing ML algorithms to conventional risk models are needed while a regulatory framework is required prior to their implementation in clinical practice.
Role of proton pump inhibitor in healing after choanal atresia repair: a randomized control trial
Authors: ElSalmawy Ahmed , Abdelfattah Gamal , Farag Tasneem , Farahat Ahmed 
Published: April 2022

AbstractBackgroundChoanal atresia (CA), defined as the anatomical closure of the choanae in the nasal cavity, is relatively uncommon disease entity with an estimated incidence of 1:5000–7000 births. Post-operative restenosis remains a common complication of the endoscopic CA repair. Risk factors for restenosis include nasopharyngeal reflux and gastroesophageal reflux.ResultsForty patients who underwent choanal atresia repair were divided randomly into 2 groups. Group A patients received postoperative PPI medication compared to group B patients who acted as control who underwent the same operation without receiving postoperative proton pump inhibitor medication.Only 2 patients (10%) in group A experienced restenosis compared to 8 patients (40%) in the control group B.ConclusionThe use of esomeprazole which is a proton pump inhibitor acting as an antireflux should be considered, in postoperative treatment, to decrease the rate of choanal restenosis by preventing inflammation on choanal mucosa which can enhance good healing mechanism.
Middle ear tumors rather than inflammatory and infective lesion: retrospective histopathological evaluation of eleven cases
Authors: Akyol Sevda , Saraydaroglu Ozlem , Ozmen Omer Afsin 
Published: April 2022

Abstract
Background
Middle ear tumors are a rare group of neoplasia due to their location. In this study, we analyzed our archives of the Department of Pathology for the middle ear tumor cases diagnosed between 2010 and 2019.

Results
Within the mentioned period, 591 cases were operated on for middle ear tumors. Eleven of these cases were diagnosed as middle ear tumors other than cholesteatoma. Considering the distribution of the cases according to histopathological diagnoses, 5 (45.4%) paragangliomas, 4 (36.3%) schwannomas, and 2 (18.2%) meningiomas were detected. No recurrence was observed in the clinical follow-up of the patients after excision.

Conclusions
Although tumors located in the middle ear, which generally cause similar clinical complaints, are rarely seen, the tissue should be evaluated histopathologically because it will affect the treatment and prognosis of the patients.
Mental health responses in countries hosting refugees from Ukraine
Authors: Kaufman Kenneth R. , Bhui Kamaldeep , Katona Cornelius 
Published: April 2022

Summary
The Ukrainian refugee crisis highlights the many issues associated with trauma, distress, mental and physical health, culturally competent assessments, and meaningful support and interventions. This crisis requires international support and a global response, as hosting countries have specific competencies and capacities. The authors hope that the groundswell of international concern over the crisis in Ukraine will lead not only to a comprehensive response to the needs of refugees from that country but also to a recognition of the needs of other asylum seekers and refugees and to our collective moral obligation to address those needs equitably.
Το εκπαιδευτικό ντοκιμαντέρ «Έλληνες Εκπρόσωποι της Σχολής του Μονάχου» ως διδακτικό εργαλείο αισθητικού γραμματισμού.
Authors: Ρωμοσιού Αρτεμις , Σιαφάκα Ελένη , Σιγούνη Ελένη , Σιμιτσή Κυριακή Βαλεντίνη , Σοφός Αλιβίζος (Λοΐζος) 
Published: April 2022

«Οι Έλληνες εκπρόσωποι της Σχολής του Μονάχου» είναι ένα εκπαιδευτικό ντοκιμαντέρ που επιχειρεί να παρουσιάσει την πορεία και το έργο τους με όχημα τις ήδη υπάρχουσες προσλαμβάνουσες των μαθητών από έργα των καλλιτεχνών που έχουν ασχοληθεί με την ηθογραφία και την παιδική ηλικία. Κεντρικός άξονας είναι τα έργα του Νικηφόρου Λύτρα, Νικολάου Γύζη, Γεώργιου Ιακωβίδη που φιλοξενούνται στην Εθνική Πινακοθήκη όπου και πραγματοποιήθηκε το γύρισμα, ενώ βασικός στόχος που δεν θα μπορούσε να περιοριστεί αποκλειστικά και μόνο στα στενά μαθησιακά όρια, είναι ο αισθητικός γραμματισμός και μια πρόταση μίας πιο ενδιαφέρουσας εμβάθυνσης στα ηχηρά ονόματα της ελληνικής τέχνης του 19ου αι. αλλά και σε βασικά καλλιτεχνικά ρεύματα και τάσεις της περιόδου.
Association of ARRDC3 and NFIA variants with bovine congestive heart failure in feedlot cattle
Authors: Heaton Michael P. , Harhay Gregory P. , Bassett Adam S. , Clark Halden J. , Carlson Jaden M. , Jobman Erin E. , Sadd Helen R. , Pelster Madeline C. , Workman Aspen M. , Kuehn Larry A. , Kalbfleisch Theodore S. , Piscatelli Heather , Carrie Michael , Krafsur Greta M. , Grotelueschen Dale M. , Vander Ley Brian L. 
Published: April 2022

Background: Bovine congestive heart failure (BCHF) has become increasingly prevalent among feedlot cattle in the Western Great Plains of North America with up to 7% mortality in affected herds. BCHF is an untreatable complex condition involving pulmonary hypertension that culminates in right ventricular failure and death. Genes associated with BCHF in feedlot cattle have not been previously identified. Our aim was to search for genomic regions associated with this disease. Methods: A retrospective, matched case-control design with 102 clinical BCHF cases and their unaffected pen mates was used in a genome-wide association study. Paired nominal data from approximately 560,000 filtered single nucleotide polymorphisms (SNPs) were analyzed with McNemar’s test. Results: The most significant genome-wide association was in the arrestin domain-containing protein 3 gene (ARRDC3), followed by the nuclear factor IA gene (NFIA, mid-p-values, 1x10-8 and 2x10-7, respectively). Animals with homozygous risk alleles at either gene were approximately eight-fold more likely to have BCHF than their matched pen mates without those risk alleles (CI95 = 3-17). Animals with homozygous risk alleles at both genes were 28-fold more likely to have BCHF than all others (p-value = 1x10-7, CI95 = 4-206). A linked missense variant in ARRDC3 (C182Y) represents a potential functional variant as the C182 codon is conserved among all other jawed vertebrate species observed. A DNA test with two markers showed 29% of 273 BCHF cases had homozygous risk alleles in both genes, compared to 2.5% in 198 similar unaffected feedlot cattle. This DNA test may be useful for identifying feedlot animals with the highest risk for BCHF in the environments described here. Conclusions: Although pathogenic roles for ARRDC3 and NFIA variants associated with BCHF are unknown, their discovery facilitates classifying animals by genetic risk and allows cattle producers to make informed decisions for selective breeding and animal health management.
Translation, validity and reliability of the Danish version of the Adolescent Insomnia Questionnaire
Authors: Andreucci Alessandro , Lund Straszek Christian , Skovdal Rathleff Michael , Guldhammer Clara , de la Vega Rocio , Palermo Tonya M. 
Published: April 2022

Background: The Adolescent Insomnia Questionnaire (AIQ), English version, is the only validated screening measure developed specifically to identify insomnia symptoms in adolescents. To date, no specific screening tool for adolescent insomnia is present in Danish language. The aim of this study was to translate and validate the AIQ in a sample of Danish adolescents. Methods: The AIQ underwent a process of forward-backward translation and pilot testing. Subsequently, data were collected at baseline and two-week follow-up from adolescents aged 11-19, who completed both the AIQ and an available adult measure of insomnia (the Athens Insomnia Scale, AIS). The internal consistency, test-retest reliability and convergent validity were assessed. Exploratory factor analysis was conducted to identify the latent factors underlying the questionnaire. Results: At baseline 185 adolescents (18% males and 82% females, mean age 16.0 years) and 102 (55.1%) at two-week follow-up completed the questionnaires. The AIQ showed excellent internal consistency for the total score (Cronbach's a: 0.88) and good convergent validity with the AIS total score (Pearson’s correlation value= 0.86, P<0.001). The test-retest reliability at two weeks was very satisfactory (ICC coefficient = 0.89; 95% CI 0.84, 0.92). Results from the exploratory factor analysis identified a three-model solution corresponding to the same three-model solution identified within the original development sample. Conclusions: The Danish version of the AIQ demonstrated satisfactory psychometric properties in terms of internal consistency, test-retest reliability and validity, which supports its use as a screening tool for the identification of insomnia symptoms in adolescents, including Danish-speaking adolescents.