bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of vacuum assisted therapy in wound healing
Authors: Ponnoju Mounika , Uppala Rajesh , Konda Varun Deep 
Published: November 2022

Background: Vacuum assisted closure (VAC) is a new technique developed in the management of contaminated, acute, and chronic wounds. It refers to wound dressing system that continuously or intermittently apply sub-atmospheric pressure to the surface of a wound which accelerates debridement and promote healing. The optimum pressure for VAC is around 125 mmhg below ambient and this negative pressure helps in removing interstitial fluid, decreases localised edema and increases blood flow. This in turn decreases tissue bacterial levels and promotes wound healing.Methods: Hospital based prospective study.Results: Most common etiology for wounds is diabetes i.e., 50%, Most common organism cultured from wound is Staphylococcus aureus, and least is proteus. Surface area of wound is reduced to <40 cm2 in 76% cases and 7% cases had >60 cm2. After applying VAC dressing 91% of patients had bright red granulation tissue. Mean duration hospital stay was reduced to 10days in patients with VAC dressing.Conclusions: VAC or NPWT therapy is an excellent alternative modality of treatment of acute or chronic large non-healing wounds. It reduces the number of changes of dressing and reduces the time of hospital stay before definitive surgery for covering wound can be planned. Based on the data from the present study and other studies available, VAC appear to result in better and rapid healing and thus a better option of wound management technique.
‘‘They could defecate over a whole people […] and defecate some more by tearing up the land”: Ecological (Un) consciousness and Resistance in Toni Morrison’s Selected Novels
Authors: Selay Marius KOUASSI 
Published: November 2022

This paper aims to deconstruct Toni Morrison’s selected novels through the lenses of ecocriticism. It looks at her work from an ecocritical angle. Sula has traditionally been read as a story about female friendship ;Song of Solomon has been critically acclaimed for its vivid capture of African American cultural heritage ; Tar Baby is regarded as a masterpiece because of its high folkloric resonance ; Beloved is perceived as a survey of the horrors of slavery ; Paradise is regarded as the narrative of contemporary communities confronted with great social changes, while A Mercy is considered to be a story of black women slaves’ struggles to gain freedom in America in the 1600s. Historically, critics have attempted to perceive Morrison’s fiction from the socio-historical lens that has little to do with Nature. However, Nature serves as a background to Morrison's work. It not only serves as imagery but more of a living being that reacts to human exploitation. Morrison's selected novels highlight diverse aspects of this human versus nature relationship that deserves an in-depth analysis. In fact, these novels provide ample evidence that the author sees ecosensitivity and ecological consciousness as possible ways to curb environmental degradation. This paper posits the nonhuman world encoded in Morrison’s novels. It maintains that Morrison’s fiction could raise awareness about ecological wisdom which is key to understanding and solving the current environmental challenges.
Mental Health Awareness for Community Development among Parents towards Responsible Parenting
Authors: Usita Maricris M. , C. Mendez Arlene 
Published: November 2022

Extending community extension programs at present is affected by the COVID-19 pandemic hence, the College of Arts, Sciences, and Technology embraced new strategies in extending learnings to the community in accordance with the strict implementation of health protocol. With the advent of technology, the College was able to materialize its first webinar extension programs in partnership with the Parents Teachers Association of Basic Education Department of Occidental Mindoro State College. The extension program aims to educate the parents on the importance of their mental health as well as ways of guarding their children’s mental health. The conduct of the extension activities covered various methods of interventions using an online platform.
The intervention program covered different topics that focus on mental health specifically with the integration of experiential learning to give the audience the opportunity to know exactly how to understand Student’s Stress Anxiety and Depression (SAD), Positive Parenting, and Mindfulness of Parents. The intervention program was conducted through lectures, discussion, question and answer, and experiential learning methods. As a result, the overall training evaluation obtained an overall mean of 4.73, which means it is very highly effective. Furthermore, to sustain the program, it must be extended with other organizations to improve service delivery.
PENGARUH STRATEGI PEMASARAN TERHADAP KINERJA PEMASARAN PRODUK OLAHAN KOPI
Authors: Fitria Shalsabillah Nur , Widayanti Sri , Laily Dona Wahyuning 
Published: November 2022

Fore Coffee is a contemporary coffee shop offering a wide variety of high-quality coffee drinks. As coffee shops in Indonesia mushroomed during the COVID-19 pandemic, Fore Coffee carried out various marketing strategies so that sales could survive in an increasingly competitive market. This research aims to describe the 7P marketing components that Fore Coffee has carried out, analyze the effect of the 7P marketing strategy that Fore Coffee has carried out on marketing performance, and explain the implications of the research results for company development. The method in this study uses descriptive analysis and a PLS analysis tool named WarpPLS 6.0 with 100 respondents who are Fore Coffee consumers at Tunjungan Plaza Mall Surabaya. The results showed that the components of the 7P strategy carried out by Fore Coffee were considered quite good by most consumers. In testing the marketing strategy on the marketing performance of Fore Coffee, it was found that all components of the marketing strategy in this study had a significant effect on the acceptance of all research hypotheses. Based on the implications of the research results, theoretically justify and strengthen several theories and previous research.
JACIII Distinguished Editor & Outstanding Reviewer Awards 2022
Authors: Office Editorial 
Published: November 2022

The JACIII Distinguished Editor and Outstanding Reviewer Awards were established for the purpose to honor editors who have made a significant contribution to the growth of the JACIII in 2018 and to acknowledge reviewers who have made a significant contribution to reviewing in 2021. We express our deepest gratitude for their professional work, which we believe conductive to development of not only the JACIII but also scientific research.
JACIII DISTINGUISHED EDITOR AWARD 2022
Bin Xin (Beijing Institute of Technology, China), Fei Yan (Changchun University of Science and Technology, China), Guohun Zhu (The University of Queensland, Australia), Jinhua She (Tokyo University of Technology, Japan), Keigo Watanabe (Okayama University, Japan), Luefeng Chen (China University of Geosciences, China), Tomohiro Yoshikawa (Suzuka University of Medical Science, Japan), Tomomi Hashimoto (Saitama Institute of Technology, Japan), Yasufumi Takama (Tokyo Metropolitan University, Japan), Zhen-Tao Liu (China University of Geosciences, China), and Zhihong Peng (Beijing Institute of Technology, China)
JACIII OUTSTANDING REVIEWER AWARD 2022
Emi Yuda (Tohoku University, Japan), Kehan Chen (Changchun University of Science and Technology, China), and Weiwu Ren (Changchun University of Science and Technology, China)
Physiological and Hormonal Effects of Titanium Dioxide Nanoparticles on Thyroid and Kidney Functions
Authors: Luaibi Noori Mohammed , Mohammed Raghda Ali 
Published: November 2022

تُستخدم الجسيمات النانوية لثاني أكسيد التيتانيوم (TiO2 NPs) بشكل عام في أنواع مختلفة من التطبيقات مثل صناعة البلاستيك، وصناعة الورق، والدهانات، ومعجون الأسنان، ومستحضرات التجميل، واقيات الشمس، وفي أنماط الحياة المختلفة، بسبب النطاق الواسع من التطبيقات وتعرضنا اليومي لهذه الجسيمات النانوية ونقص المعلومات عن صحة الحيوان والأنسان ، صُممت هذه الدراسة للكشف عن الآثار التي تعتمد على الجرعة والوقت من TiO2-NPs على وظائف الغدة الدرقية والكلى في ذكور الجرذان.
لهذا الغرض تم استخدام 54 ذكر من الجرذان البيض وتم تصنيفها الى ثلاثة مجاميع رئيسية ( 3,2,1) كل مجموعه تتضمن 18 جرذ عوملت بثلاث فترات زمنية مختلفة (1 ,2 ,4) أسابيع على التوالي. وتم تقسيم هذه المجاميع الى ثلاث مجاميع فرعية كل منها تتضمن ست حيوانات تمت معاملتها على النحو التالي : (1) سيطرة , المجموعة (2 ,3) حقنت بالتجويف البروتوني بجرعات متزايدة من دقائق التيتانيوم النانوية (50 ,200) ملغ / كغم على التوالي. , في نهاية التجربة شرحت الجرذان وتم حساب وزن الغدة ووزن الكلى اليمنى واليسرى . النتائج اظهرت انخفاض معنوي عالي (p≤ 0.01) في وزن الغدة الدرقية وارتفاع معنوي عالي (p≤ 0.01) في وزن الكلى وفي مستوى هرمون TSH ويوريا الدم والكرياتين ومعدل البروتين الكلي , بينما انخفاض معنوي عالي في مستويات هرمون T3 و T4 المعاملة بجرعات مختلفة من 50- 200 ملغم / كغم TiO2في جميع الفترات الزمنية (1،2،4) اسابيع . توضح نتائج الدراسة الحالية انخفاضًا كبيرًا في مستوى مصل T4 و T3 مع التعرض لـ TiO2 NPS الذي يعطل وظيفة الغدة الدرقية ، بينما يرفع TiO2 NPS مستوى اليوريا والبروتين الكلي والكرياتينين. يمكن أن يكون هذا مرتبطًا بالجرعة العالية من TiO2-NPs ومدة الدراسة ، مما تسبب في تنكس ونخر خلايا الكلى وتلف في الحويصلات مما أدى إلى منع الإفراز الذي رفع مستويات اليوريا في الدم ، كما أدى إلى مستويات عالية من الكرياتينين والبروتين الكلي في المصل بسبب الخلل الذي حدث في وظائف الكلى.
Synthesis and Characterization of Some New Pyridine and Pyrimidine Derivatives and Studying Their Biological Activities
Authors: Al-Hussein Israa R. A. , Al-Shuhaib Zainab A. M. 
Published: November 2022

تعتبر الأنظمة الحلقية غير المتجانسة ضرورية في الكيمياء الطبية بسبب نشاطها الواعد السام للخلايا، واحدة من أهم عائلات الجزيئات العضوية الموجودة في الطبيعة أو المحضرة في المختبر. نتيجة لذلك، تم مفاعلة المركب 3 N-(4-nitrophenyl)-3-oxobutanamide مع الثيويوريا و اندول-3-كاربوكسالديهيد و piperonal على التوالي لتحضير بعض مشتقات البيريميدين 5a و 5b. كذلك حضر المركب 9 من تفاعل ثايوفين-2-كاربوكسالديهيد مع اثيل سيانواسيتيت واليوريا بوجود كاربونات البوتاسيوم كعامل مساعد. وحضرت مركبات الجالكونات 11a و11b من تفاعل كميات مولية متساوية من كل من 1-نفثالديهيد و كوينولين-2-كاربوكسالديهيد على التوالي من كل من 4-برومواسيتوفينون و 4-فلورواسيتوفينون على التوالي . وحضر مركب البيرميدين 13من تفاعل مركب الجالكون 11a مع كواندين هيدروكلوريد 12 بوجود هيدروكسيد البوتاسيوم. كما حضرت مشتقات البريدين 14 و16 من تفاعل مركب الجالكون 11b مع اثيل سيانواسيتيت وخلات الامونيوم في حامض الخليك الثلجي، حضر بهذه الطريقة المركب .14 كذلك تم مفاعلة 4-مثيل بنزالديهيد مع 4-فلورواسيتوفينون واثيل سيانواسيتيت وخلات الامونيوم في ن-بيوتانول لتحضير المركب 16. شخصت جميع المشتقات المحضرة باستعمال التقنيات الطيفية (FT-IR و 1H-NMR و 13C-NMR)، فضلا عن أطياف الماس EI-MS)) للتحقق من الصيغ التركيبية للمشتقات المحضرة. كما فحصت فعالية المشتقات المحضرة المضادة للسرطان ضد نوعين من السلالات المختلفة من الخلايا السرطانية البشرية، MCF-7 (خلايا سرطان الثدي) وHepG2 (خلايا سرطان الكبد). فقد أظهر المركبين 5a و14 أنشطة سامة للخلايا ضد خلايا HepG2 بقيم IC50 تبلغ 43.84 و57.14 ميكروغرام / مل على التوالي. بالإضافة إلى ذلك، فقد أظهر مركب البريدين 14 نشاطًا سامًا للخلايا ضد خلايا MCF-7 بقيمة IC50 تبلغ 50.84 ميكروغرام/ مل. كما درست الخصائص المضادة للبكتيريا الموجبة والسالبة لصبغة كرام والطفيليات (E. granulosus protoscoleces) للمشتقات المحضرة.
Green synthesis of nano binary oxide SiO2/V2O5 NPs integrated ointment cream application on wound dressings and skin cancer cells
Authors: Ali Marwa , Drea Abbas A-Ali 
Published: November 2022

اشتملت الدراسة الحالية على تحضير المزدوج النانو SiO2/V2O5 باستخدام مواد طبيعية خام كمادة أولية حيث استخدمت رماد قشور الارز بعد حرقها بدرجة °C700 سيليزية للتخلص من المواد العضوية واللاعضوية في القشور حيث كانت هي المادة الخام لاستخلاص السليكا جل والتي تم مزجها مع أوكسيد الفناديوم الخماسي وتم تشخيص المزدوج النانو SiO2/V2O5 المحضر باستخدام عدة تقنيات مثل الأشعة السينية ,المجهر الالكتروني الماسح عالي الدقة حيث تم حساب معدل الحجم الحبيبي باستخدام صورة المجهر الالكتروني الماسح للسطح المادة المحضرة عند المقياس 200 نانومتر , مطيافية تشتت الطاقة بالأشعة السينية التي استخدمت لكشف تركيز العناصر الموجودة في النموذج المحضر SiO2/V2O5 من مادة قشور الارز الخام وتقديرها كميا ونوعيا وكذلك تم قياس المساحة السطحية للسليكا المستخلص والمزدوج المحضر SiO2/V2O5 والمقارنة بينهما كما موضح في النتائج كما تضمنت الدراسة البحثية الفعالية البيولوجية للمزدوج SiO2/V2O5 وتأثيرها على تثبيط النمو البكتيري بعد أن تم تطبيق المادة النانوية المحضرة على ضمادات الجروح حيث أعطت نتيجة واعدة لاستخدامها كضمادات موضعية تعمل على إزالة الميكروبات وخاصة لمرضى الحروق والجروح وذلك بسبب فعاليتها العالية لقتل البكتيريا الموجبة S.aurea عند تركيزµg/mL 625 التي تتميز بمقاومتها للعديد من المضادات الحيوية . تعتبر مقاومة المضادات الحيوية من المشكلات التي يسعى العديد من الباحثين لحل هذه المشكلة من خلال توفير مضادات حيوية أكثر فعالية وأمانًا. اختيار مادة السيليكا المستخلصة من مادة طبيعية لتقليل السمية الناتجة عن استخدام الكيماويات ، حيث تعتبرالسيليكا مادة غير سامة. لذلك ، أثناء التحضير ، تم الحرص على استخدام المواد الكيميائية بتراكيز منخفضة لتقليل السمية. تم دراسة التأثيرات السامة للخلايا في المختبر SiO2 / V2O5)) NPs على خط الخلايا الطبيعية Vero 101 وخط خلايا الجلد A431 وتم فحصهما بتراكيز مختلفة. تم استخدام MTT (3- (4،5-dimethylthiazol-2-yl) -2،5-diphenyltetrazolium bromide) لتحديد التأثيرات السامة للخلايا للمساحيق النانوية الخضراء المُصنّعة.
An Integrated Method to Mitigate Hazards from Hydraulic Fracturing–Induced Earthquakes in the Duvernay Shale Play
Authors: Hui Gang , Gu Fei 
Published: November 2022

Summary
In recent decades, a remarkable increase in induced seismicity in the Western Canada Sedimentary Basin (WCSB) has been largely attributed to hydraulic fracturing (HF) operations in unconventional plays. However, a mitigation strategy concerning geological, geomechanical, and operational susceptibilities to HF-induced seismicity has not been well understood. This work proposes an integrated method to mitigate potential risks from HF-induced seismicity in the Duvernay play near Crooked Lake. The geological susceptibility to induced seismicity is evaluated first from site-specific formation pressure and a distance to the Precambrian basement. The regional in-situ stress and rock mechanical properties are then assessed to determine the geomechanical susceptibility to induced seismicity. Next, the operational factors are determined by comparing induced seismicity with operational parameters such as total injection fluids and proppant mass. It is found that regions with a low formation pressure (&lt;60 MPa), a great distance from the base Duvernay to the Precambrian basement (&gt;260 m), a low minimum principal stress (&lt;70 MPa), and a low brittleness index (&lt;0.45) tend to be induced-seismicity-quiescent regions. Finally, a multiple linear regression (MLR)-based approach is proposed by considering the relative importance of different parameters. The MLR analysis indicates that brittleness index, formation pressure, and total injection volume are the top three controlling factors. Three new horizontal wells are drilled and the MLR analysis of these wells using the three most important parameters is conducted. High-resolution monitoring results indicated that 95% of the induced events had a local magnitude of less than 2.0 during and after the HF operations (3-month time window and 5-km well-event distance), among which the maximum magnitude reached ML3.05 (&lt;red light magnitude ML4.0). Therefore, the MLR-based approach was successfully validated, suggesting that this approach can be applied to mitigate potential seismicity risks in upcoming wells in the Fox Creek region. Such a workflow can also be applied to other regions to guide seismicity-free fracturing operations in unconventional plays.
Upscaling of Transport Properties in Complex Hydraulic Fracture Systems
Authors: Song Wenhui , Prodanovic Masa , Santos Javier E. , Yao Jun , Zhang Kai , Yang Yongfei 
Published: November 2022

Summary
Fluid flow in complex fracture systems near wellbore is influenced by heterogeneous fluid pathway structure, proppant distribution, and stress-induced fracture aperture change. The current physical experiments and pore-scale simulations only study the multiphase flow properties of hydraulic fracture (HF) with no proppant while the multiphase flow properties of induced fracture network (IFN) and HF with proppant are not available. It is well known that the simplified “straightline” relative permeability model does not apply to multiphase flow in IFN and HF with proppant. Consequently, there is no upscaled relative permeability model that works. In this study, we develop the physics-driven level set lattice Boltzmann method (LS-LBM)-coupled model to study multiphase flow properties in complex fractures during injected water flowback and propose the upscaled relative permeability models of IFN and HF with proppant. The imaged HF is applied to generate HFs with different aperture and proppant distributions using morphology operation and discrete element method (DEM). The imaged IFN is further applied to generate IFN with different aperture distributions by image dilation. The oil/water interface at different drainage pressures is tracked by LS, and the resultant fluid distributions are applied to calculate each phase’s effective permeability by LBM. We found that the aperture variation coefficient difference leads to various fluid expansion patterns in IFN and HF. The oil/water interface moving pattern exhibits “face expansion” in IFN and HF while the oil/water interface moving pattern resembles “finger expansion” in HF with embedded proppant with notably larger aperture variation coefficient. The upscaled relative permeability model is further established considering channel tortuosity variation and pore structure difference based on LS-LBM simulation results.
Association of TNFα -308G/A and IL10 -1082A/G Polymorphisms with Pulmonary Tuberculosis Susceptibility in a Brazilian population
Authors: Montenegro Lílian Maria Lapa , Carvalho-Silva Wlisses Henrique Veloso , Nascimento André Alves do Nascimento , Peixoto Aline dos Santos , Cruz Heidi Lacerda Alvez , Cardoso Marcus Vinicius , Balbino Valdir de Queiroz , Schindler Haiana Charifker 
Published: November 2022

Abstract
Pulmonary tuberculosis (PTB) remains a major cause of morbidity and mortality in developing countries. The course of Mycobacterium tuberculosis infection is regulated by mainly two antagonistic cytokines that are produced and secreted by T cells, TNF-α and IL-10. Differences in TNFα and IL10 genes expression and protein production affected by single nucleotide polymorphisms (SNPs) have been demonstrated influence PTB susceptibility. Therefore, this study aimed to evaluate a possible association between the functional polymorphisms of TNFα (-308G/A, rs1800629) and IL10 (-1082A/G, rs1800896) cytokines genes with susceptibility or resistance to active PTB in patients from Pernambuco state. We carried out a case-control study of 71 patients with active pulmonary tuberculosis (PTB + group), 105 patients with nonspecific lung disease (TB- 1 and TB- 2 groups) and 101 clinically healthy individuals (healthy control), to explore the association of cytokine polymorphisms, sociodemographic, clinical, and epidemiological variables with developing of PTB. TNFα -308G/A and IL10 -1082A/G genotyping was performed by TaqMan qPCR system. The univariate and logistic regression analyses demonstrated statistically association of male sex (OR = 13.741; 95%CI = 5.794–32.589; P = < 0,001) and age (OR = 1.030; 95%CI = 1.005–1.055; P = 0.017) with PTB susceptibility, as risk factors. Regarding genetic variables, IL10 -1082 G variant allele, AG and GG genotypes were also associated with developing of PTB as risk factors (OR = 2.777, 95%CI = 1.710–4.544, P = < 0.001; OR = 2.289, 95%CI = 1.095–4.849, P = 0.024; and OR = 6.572, 95%CI = 2.262–21.242, P = < 0.001, respectively), and maintained associated in the logistic regression dominant model (OR = 7.998, 95%CI = 2.719–23.519, P = < 0.001). Significant association was also observed between TNFα -308 GA genotype and PTB susceptibility, but as protector factor in univariate analysis (OR = 0.375, 95%CI = 0.179–0.766, P = 0.005), and logistic regression dominant model associated the genotypes carrying A allele variant (OR = 0.386, 95%CI = 0.172–0.865, P = 0.021). The study showed important role of IL10 and TNFα SNPs in developing PTB in a Brazilian population, being possible biomarkers for tuberculosis susceptibility.
Research on Single-phase Groinding Fault Location Based on ESMD-SDEO
Authors: Huang Xiaoping , Lu Qiu , Zhou Hongkai , Wen Fangyi , Huang Wenzhe 
Published: November 2022

Abstract
Aiming at the fault location problem of multi branch cable hybrid lines, this paper studies a fault traveling wave two terminal location method based on ESMD and the Symmetric Differential Energy Operator (SDEO), and puts forward a configuration scheme of traveling wave location device considering economy and actual location needs. Firstly, the post fault transient voltage signal of the traveling wave distance measuring device is collected and transformed into a new phase mode matrix. Then the line mode component is decomposed by ESMD to obtain the first empirical mode M1 component, and the arrival time of the initial traveling wave head is identified by SDEO method. Finally,the method judges the fault area through the distance measurement between the Feeder Terminal Unit(FTU) and the head and end of the trunk line, summarizes the distance from the traveling wave ranging device point in the fault area to the fault point, establishes the fault judgment matrix, determines the branch of the fault point according to the corresponding judgment rules, and then calculates the distance of the fault point and the pole number of the fault.