bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low‐intensity extracorporeal shockwave therapy for diabetic men with erectile dysfunction: A systematic scoping review
Authors: Mason Matthew M. , Pai Raghav K. , Masterson John M. , Lokeshwar Soum D. , Chu Kevin Y. , Ramasamy Ranjith 
Published: June 2022

AbstractBackgroundErectile dysfunction (ED) is a very common complication in men with diabetes mellitus (DM). Low‐intensity extracorporeal shockwave therapy (Li‐ESWT) offers a promising nonsurgical treatment option for ED. A systematic scoping review investigating the outcomes of Li‐ESWT in diabetic men with ED has not yet been performed.ObjectivesTo systematically review animal and clinical studies related to the use of Li‐ESWT for treatment of DM‐related ED.Data sourcesPubMed, Embase, The Cochrane Library, Scopus, and Web of Science were searched, unrestricted by dates or study design.Materials and methodsWe included qualitative studies, quantitative studies, primary research studies, meta‐analyses, and research letters written in English. Full text reviewing was completed in all animal and human studies discussing Li‐ESWT for the treatment of ED in subjects with DM. Data extracted included the journal citation, publication year, country of origin, study design, and a summary of the pertinent findings.ResultsOur search yielded nine clinical studies and 10 animal studies. The results of the clinical studies suggest that Li‐ESWT is a safe and effective treatment in men with well‐controlled DM and moderate or better ED. However, the benefit is less durable in diabetic men than nondiabetic men. The results of the animal studies suggest that Li‐ESWT can significantly improve erectile function in diabetic rat models with ED.ConclusionsThe examined studies present encouraging results for the use of Li‐ESWT to treat diabetic men with ED. Future studies, particularly robust randomized controlled trials, are necessary to confirm these findings and provide long‐term follow‐up.
A single centre audit: repeat pre‐operative colonoscopy
Authors: Chen Michelle Zhiyun , Devan Nair Hareshdeva , Saboo Apoorva , Lee Sharon Chih Lin , Gu Xinchen , Auckloo Sheik Mohammad Azhar , Tamang Sandeep , Chen Sally Jiasi , Lowe Ryan William , Strugnell Neil 
Published: June 2022

AbstractBackgroundRepeat colonoscopy may be required for tumour localisation. The aim of the study is to explore the clinical settings it was used and benchmark the quality of initial colonoscopy against standardized guidelines for tumour localisation, tattooing and colonoscopy reporting amongst clinicians.MethodsA retrospective study from 2016 to 2021 has been performed on patients who underwent elective colorectal cancer resections at the Northern Hospital. Patient demographics, colonoscopic and operative details were retrieved from the Bi‐National Colorectal Cancer Audit (BCCA) Registry database and hospital medical records. Primary outcomes: changes in operative approach and delays to operation. Secondary outcomes: reasons for a repeat colonoscopy and complications from repeat colonoscopy.ResultsA total of 339 patients were included in this study. 94 (28.6%) underwent a repeat colonoscopy. Re‐scoping rate was 29.6% for surgeons, and 26.2% for non‐operating endoscopists. Surgeons had a 5.9% localisation error rate, and non‐operating endoscopist 6.95% (p = 0.673). Surgeons did not have a lower rate of repeat colonoscopy (p = 0.462). Repeat endoscopy was associated with a longer time to definitive operation (p < 0.001). No complications were associated with a repeat colonoscopy.ConclusionThere was no difference in localisation error rates or repeat colonoscopy amongst surgeons (29.6%) and non‐operating endoscopists (26.2%) (p = 0.462). This could be explained by the standardized endoscopy training in Australia governed by a common training board. Lack of tattooing at index colonoscopy and inadequate documentation often led to a repeat endoscopy, which was associated with a longer time to definitive operation. Standardized guidelines in tattooing of lesions and colonoscopy reporting should be implemented.
Optimizing sensory fiber activation during cervical transcutaneous spinal stimulation using different electrode configurations: A computational analysis
Authors: de Freitas Roberto M. , Capogrosso Marco , Nomura Taishin , Milosevic Matija 
Published: June 2022

AbstractBackgroundCervical transcutaneous spinal cord stimulation (tSCS) is a rehabilitation tool which has been used to promote upper‐limb motor recovery after spinal cord injury. Importantly, optimizing sensory fiber activation at specific spinal segments could enable activity‐dependent neuromodulation during rehabilitation.MethodsAn anatomically realistic cervical tSCS computational model was used to analyze the activation of α‐motor and Aα‐sensory fibers at C7 and C8 spinal segments using nine cathode electrode configurations. Specifically, the cathode was simulated at three vertebral level positions: C6, C7, and T1; and in three sizes: 5.0 × 5.0, 3.5 × 3.5, and 2.5 × 2.5 cm2, while the anode was on the anterior neck. Finite element method was used to estimate the electric potential distribution along α‐motor and Aα‐sensory fibers, and computational models were applied to simulate the fiber membrane dynamics during tSCS. The minimum stimulation intensity necessary to activate the fibers (activation threshold) was estimated and compared across cathode configurations in an effort to optimize sensory fiber activation.ResultsOur results showed that nerve fibers at both C7 and C8 spinal segments were recruited at lower stimulation intensities when the cathode was positioned over the C7 or T1 vertebra compared with the C6 position. Sensory fibers were activated at lower stimulation intensities using smaller electrodes, which could also affect the degree of nerve fiber activation across different positions. Importantly, Aα‐sensory fibers were consistently recruited before α‐motor fibers.ConclusionsThese results imply that cathode positioning could help optimize preferential activation of hand muscles during cervical tSCS.
Reader reaction to “Outcome‐adaptive lasso: Variable selection for causal inference” by Shortreed and Ertefaie (2017)
Authors: Baldé Ismaila , Yang Yi Archer , Lefebvre Geneviève 
Published: June 2022

AbstractShortreed and Ertefaie introduced a clever propensity score variable selection approach for estimating average causal effects, namely, the outcome adaptive lasso (OAL). OAL aims to select desirable covariates, confounders, and predictors of outcome, to build an unbiased and statistically efficient propensity score estimator. Due to its design, a potential limitation of OAL is how it handles the collinearity problem, which is often encountered in high‐dimensional data. As seen in Shortreed and Ertefaie, OAL's performance degraded with increased correlation between covariates. In this note, we propose the generalized OAL (GOAL) that combines the strengths of the adaptively weighted L1 penalty and the elastic net to better handle the selection of correlated covariates. Two different versions of GOAL, which differ in their procedure (algorithm), are proposed. We compared OAL and GOAL in simulation scenarios that mimic those examined by Shortreed and Ertefaie. Although all approaches performed equivalently with independent covariates, we found that both GOAL versions were more performant than OAL in low and high dimensions with correlated covariates.
A questionable version of the Post‐Traumatic growth inventory—Short form in women diagnosed with breast cancer
Authors: Porro Bertrand , Broc Guillaume , Baguet‐Marin Fanny , Cousson‐Gélie Florence 
Published: June 2022

AbstractObjectivesBecause the full version of the Post‐Traumatic Growth Inventory was considered too long, a short English version (10 items/five factors) was initially proposed in the literature (PTGI‐SF). Thereafter another short Italian version (10 items/five factors) and a unidimensional English version (11 items) were proposed. This study aimed at evaluating which of these three versions of the PTGI‐SF could be best adapted to women diagnosed with breast cancer.DesignCross‐sectional and psychometrics study.MethodsA total of 239 breast cancer patients or survivors were included in the study. To assess all items related to the different PTGI‐SF candidate versions; the full‐length PTGI has been used to measure PTG. A set of psychometric analyses, including a confirmatory factor analysis, composite reliability and construct validity has been performed.ResultsThe English unidimensional version did not fit the data (SB‐Chi2 = 184.47, df = 42, p < .001; SB‐RMSEA = .119; SB‐CFI = .814; SB‐TLI = .757; SRMR = .083). Both the English (SB‐Chi2 = 61.40, df = 25, p < .001; SB‐RMSEA = .078; SB‐CFI = .948; SB‐TLI = .907; SRMR = .048) and Italian (SB‐Chi2 = 26.52, df = 25, p > .05; SB‐RMSEA = .016; SB‐CFI = .998; SB‐TLI = .996; SRMR = .026) versions (10 items/five factors, respectively) showed satisfactory psychometric results.ConclusionFurther investigations are thus required to identify which of these two versions of the PTGI‐SF is the most appropriate for women diagnosed with breast cancer.
Biological effectiveness and relative biological effectiveness of ion beams for in‐vitro cell irradiation
Authors: Li Heng 
Published: June 2022

AbstractBiological effectiveness and relative biological effectiveness are critical for proton and ion beam radiotherapy. However, the relationship between the two quantities and physical character of ion beams is not well established. By analyzing 1188 sets of in‐vitro cell irradiation experiments using ion beams ranging from protons to 238U, compiled by the Particle Irradiation Data Ensemble (PIDE) project, the biological effectiveness of the ion beams, with cell survival fractionation (SF) as the endpoint, was found to be dependent on the fluence and linear energy transfer (LET) of the ion beam. Consequently, the relative biological effectiveness of the ion beam to photon beam was also established as a function of LET. A common form of relationship among SF, fluence, and LET was found to be valid for all ion beam experiments. The close form relationship could be used for proton and ion beam radiotherapy applications.
The benefit of scratch patch testing to demonstrate ocular contact allergy to brimonidine tartrate
Authors: Ringuet Julien , Lajoie Caroline , Bourgault Serge , Simonyan David , Houle Marie‐Claude 
Published: June 2022

AbstractIntroductionOcular allergies to brimonidine are frequent in patients treated for glaucoma. There is variability in reporting due to the lack of diagnostic criteria and the absence of cutaneous testing. Many false‐negative patch tests (PT) have been described. Alternative methods, such as strip and scratch PT, have been used without a standardized method.ObjectivesThe primary objective is to identify the best method of cutaneous testing and brimonidine concentration for patch testing. The secondary objective is to identify clinical signs and symptoms suggestive of ocular allergy.Patients and MethodsA retrospective review of patient files suspected of brimonidine ocular allergy was performed. Patch testing method, brimonidine concentration and clinical symptoms were reviewed.ResultsOf the 36 patients identified, half tested positive for brimonidine for at least one of the testing methods. The scratch PT demonstrated 17 positive reactions (94% detection rate). Three patients reacted with strip PT. No positive results were found with standard PT. The 5% brimonidine concentration demonstrated the highest sensitivity. The absence of eyelid pruritus was associated with negative testing.ConclusionIn the investigation of ocular allergy to brimonidine, scratch PT proved to be an essential tool. Brimonidine 5% pet. appeared as the most sensitive concentration for scratch PT.
Outcomes of living‐donor liver transplantation for acute‐on‐chronic liver failure based on newly proposed criteria in Japan
Authors: Toshima Takeo , Harada Noboru , Itoh Shinji , Morita Kazutoyo , Nagao Yoshihiro , Kurihara Takeshi , Tomino Takahiro , Kosai‐Fujimoto Yukiko , Morinaga Akinari , Tomiyama Takahiro , Yoshizumi Tomoharu 
Published: June 2022

AbstractAimRecently, new diagnostic criteria for acute‐on‐chronic liver failure (ACLF) were established in Japan. However, there is little evidence regarding the feasibility of classifying patients undergoing living‐donor liver transplantation (LDLT). The aim was to re‐evaluate the impact of these new diagnostic criteria on ACLF and the severity classification of patients undergoing LDLT.MethodsWe collected data of 82 recipients who underwent LDLT for liver failure between 1997 and 2020 and reviewed it retrospectively.ResultsOf the 82 patients with liver failure, 31 (37.8%) were diagnosed with ACLF; Grade 0 (n = 6), Grade 1 (n = 7), Grade 2 (n = 9), and Grade 3 (n = 9). There was no substantial difference in overall survival (OS) and the occurrence of postoperative complications between liver failure patients with and without ACLF. The OS after LDLT was significantly different among the four groups of ACLF patients (P = .036). Interestingly, ACLF Grade 3 patients had substantially lower OS compared to other ACLF groups even after LDLT (P = .006; 5‐year OS rates, 33.3% vs. 85.9%).ConclusionProper use of the new diagnostic criteria for ACLF in Japan demonstrated that the presence and severity of ACLF, especially the presence of multiple organ failures, leads to morbidity and mortality even in an LDLT setting. Considering that the patients with ACLF Grade 3 do not have the favorable outcomes of LDLT, deceased‐donor liver transplantation usage, or LDLT before reaching the severity of Grade 3 may be suitable for further research.
Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo‐controlled, double‐blind phase I/Ib studies in healthy subjects and patients
Authors: Vissers Maurits F. J. M. , Heuberger Jules A. A. C. , Groeneveld Geert Jan , Oude Nijhuis Jerome , De Deyn Peter Paul , Hadi Salah , Harris Jeffrey , Tsai Richard M. , Cruz‐Herranz Andres , Huang Fen , Tong Vincent , Erickson Rebecca , Zhu Yuda , Scearce‐Levie Kimberly , Hsiao‐Nakamoto Jennifer , Tang Xinyan , Chang Megan , Fox Brian M. , Estrada Anthony A. , Pomponio Robert J. , Alonso‐Alonso Miguel , Zilberstein Moshe , Atassi Nazem , Troyer Matthew D. , Ho Carole 
Published: June 2022

AbstractRIPK1 is a master regulator of inflammatory signaling and cell death and increased RIPK1 activity is observed in human diseases, including Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS). RIPK1 inhibition has been shown to protect against cell death in a range of preclinical cellular and animal models of diseases. SAR443060 (previously DNL747) is a selective, orally bioavailable, central nervous system (CNS)–penetrant, small‐molecule, reversible inhibitor of RIPK1. In three early‐stage clinical trials in healthy subjects and patients with AD or ALS (NCT03757325 and NCT03757351), SAR443060 distributed into the cerebrospinal fluid (CSF) after oral administration and demonstrated robust peripheral target engagement as measured by a reduction in phosphorylation of RIPK1 at serine 166 (pRIPK1) in human peripheral blood mononuclear cells compared to baseline. RIPK1 inhibition was generally safe and well‐tolerated in healthy volunteers and patients with AD or ALS. Taken together, the distribution into the CSF after oral administration, the peripheral proof‐of‐mechanism, and the safety profile of RIPK1 inhibition to date, suggest that therapeutic modulation of RIPK1 in the CNS is possible, conferring potential therapeutic promise for AD and ALS, as well as other neurodegenerative conditions. However, SAR443060 development was discontinued due to long‐term nonclinical toxicology findings, although these nonclinical toxicology signals were not observed in the short duration dosing in any of the three early‐stage clinical trials. The dose‐limiting toxicities observed for SAR443060 preclinically have not been reported for other RIPK1‐inhibitors, suggesting that these toxicities are compound‐specific (related to SAR443060) rather than RIPK1 pathway‐specific.
Is conferralism descriptively adequate?
Authors: Alcoff Linda Martín 
Published: June 2022

AbstractThis paper will develop a set of concerns about a central feature of Ásta's account of social categories that she calls “conferralism.” I argue that generalist approaches to social categories such as Ásta provides are inadequate as a way of understanding the diverse formations of diverse categories, and that conferralism overemphasizes the power of top‐down forces (what she calls “persons with standing”) to confer social identities. This approach then underplays the horizontal and bottom‐up influences on category formation as well as the historical formation of many social identities, especially ethnicity and race. Conferralism sets aside not only physical differences that play a role in some categories but also group‐related historical experiences and practices that produce the “base properties” that justify the use of social identity categories.
Reducing the dependency of having prior domain knowledge for effective online information retrieval
Authors: Zammit Omar , Smith Serengul , Windridge David , De Raffaele Clifford 
Published: June 2022

AbstractSometimes Internet users struggle to find what they are looking for on the Internet due to information overload. Search engines intend to identify documents related to a given keyphrase on the Internet and provide suggestions. Having some background knowledge about a topic or a domain will help in building effective search keyphrases that will lead to accurate results in information retrieval. This is further pronounced among students that rely on the internet to learn about a new topic. Students might not have the required background knowledge to build effective keyphrases and find what they are looking for. In this research, we are addressing this problem, and aim to help students find relevant information online. This research furthers existing literature by enhancing information retrieval frameworks through keyphrase assignment, aiming to expose students to new terminologies, therefore reducing the dependency of having background knowledge about the domain under study. We evaluated this framework and identified how it can be enhanced to suggest more effective search keyphrases. Our proposed suggestion is to introduce a keyphrase Ranking Mechanism that will improve the keyphrase assignment part of the framework by taking into consideration the part‐of‐speech of the generated keyphrases. To evaluate the proposed approach, various data sets were downloaded and processed. The results obtained showed that our proposed approach produces more effective keyphrases than the existing framework.
Political ecologies of resettlement in river deltas
Authors: Neu Friedrich Nikolaus , Fünfgeld Hartmut 
Published: June 2022

AbstractIn river deltas, human interference with regional and global socio‐ecological systems has led to a plethora of gradual and more abrupt environmental changes that result in inundation, coastal and river bank erosion, land loss and, ultimately, displaced people. Often apolitically framed as protective, state‐led transfer of people to new housing grounds,resettlementhas become a common response to such displacements. In its process, existing arrangements of land tenure and occupancy and, at times more covertly, related arrangements of capital, labor and the social fabric become dislocated and reassembled. In line with emerging critical geographies of resettlement, this paper conceptualizes resettlement in river deltas against the background of environmental change as a highly political process with far‐reaching environmental, economic, social and cultural implications. For this article is based on an in‐depth review of both resettlement and political ecology literature, we first elucidate the concept of resettlement before providing a structured overview of categories and recent trends in resettlement literature. We then focus on river deltas that due to multi‐scale environmental change are about to become hotspots of future resettlement. Building on identified gaps in resettlement literature, the article concludes with opening up three analytical strands of political ecology as entry points to resettlement studies, understood as critical geographic research into localized manifestations of environmental change in river deltas. Overall, our paper aims to initialize conceptual debate, grounded in a thorough review of recent case study literature on resettlement that is informed by political ecology. The review challenges positivist reductions of resettlement processes as technocratic‐managerial tasks that so far have dominated scientific literature in this field and opens up new perspectives for critical research on resettlements in river deltas for human geographers.
Illegalities in the online trade of stingless bees in Brazil
Authors: Carvalho Antônio F. 
Published: June 2022

Abstract
Stingless bees are commercialised in Brazil through the internet. Such trade has mixed populations and introduced species, allows the potential dissemination of hitchhiker symbionts and diseases, and mostly does not follow national legislation policies.
At least 33 species of stingless bees have been exploited by e‐commerce; eight others were not confirmed. All transactions found are in the surface web and most sellers do not fulfil legal requirements. Such results suggest that there is little need of anonymity for sellers, a fact that strengthens conclusions on the recurrently reported lack of successful law enforcement against illegal wildlife trade in the country.
Critical geographical zones in Brazil, where sellers of stingless beehives are concentrated, are primarily in the Atlantic Forest. Urgent policy measures and scientific evaluations are necessary for both conservation of bees and risk control of pathogens. The most promising strategy to avoid the threats regarding movement of bees is the education of stingless bee keepers.
Assessment of executive functions and physical activity in girls and boys with normal weight, overweight and obesity
Authors: Patraca‐Camacho Lorena , Cibrián‐Llanderal Tamara , Acosta‐Mesa Héctor‐Gabriel , Rodríguez‐Landa Juan Francisco , Romo‐González Tania , Rosas‐Nexticapa Marcela , Herrera‐Meza Socorro 
Published: June 2022

SummaryObjectiveTo evaluate the association between body mass index (BMI) and performance of executive functions (EFs) in girls and boys with 9‐ and 10‐year‐old schoolchildren with moderate‐ to vigorous‐intensity physical activity (MVPA) and sedentary behaviour.MethodsA total of 120 schoolchildren (61 girls and 59 boys) were evaluated anthropometrically. The MVPA was evaluated with a self‐report questionnaire. EFs were measured using a neuropsychological battery of Executive Functions and Frontal Lobes‐2 (BANFE‐2).ResultsA high BMI was associated with longer delay in completing inhibitory control tests (p = 0.00, rp = 0.32) and working memory (p = 0.00, rp = 0.26). We observed correlations in time (p = 0.00, rp = −0.43) and hits (p = 0.04, rp = −0.27) of self‐directed signalling test in boys; and girls in alphabetical words order (p = 0.00, rp = −0.39). Active normal weight schoolchildren (ANw) performed better by successfully completed the working memory tasks (H = 26.97, p = 0.00) than sedentary schoolchildren with overweight and obesity. In addition, overweight‐active schoolchildren (AOw) showed better performance on working memory tests in time (p = 0.00) and hits (p = 0.01) than their sedentary peers. Multiple linear regression analysis revealed a significant association between BMI and EFs scores (F = 2.41, df = 98, p = 0.001).ConclusionsEFs are affected by a high BMI and sedentary behaviour in school children. Boys and girls reflected differences to solve the same challenges. The MVPA has a positive effect on executive control skills mainly in overweight children.