bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soviet Publications of Holocaust Diaries in the 1960s: Anne Frank and Masha Rolnikaite
Authors: Estraikh Gennady 
Published: March 2022

ABSTRACT
A strict ban on organized Jewish activities apart from those of a limited number of religious bodies, coupled with the state monopoly on all publishing, simplified the Soviet Union’s control over Holocaust-related publication. The appearance of any such work was an idiosyncratic event, associated with concurrent political and cultural contexts and official agendas. The relatively liberal climate of the first post-Stalinist decade raised the possibility of such events. Soviet publication of both the diary of Anne Frank and Masha Rolnikaite’s I Must Tell reflected in part foreign policy considerations, but each played a rather different role in the Soviet cultural sphere. Anne Frank’s diary—not reprinted for three decades—would be referred to as, and possibly read only as, an important anti-fascist narrative with distant relevance to wartime events in the Soviet Union. Masha Rolnikaite (Rolnik), a survivor of the Vilnius ghetto, would become a widely published belletrist “Soviet Anne Frank.”
Safety and Benefits of Intraoperative Enteral Nutrition in Critically Ill Pediatric Burn Patients: A Systematic Review and Pooled Analysis
Authors: Hudson Alexandra S , Morzycki Alexander D , Wong Joshua 
Published: March 2022

Abstract
Burn injuries significantly increase a patient’s metabolic demand. Adequate nutrition is essential as an adjunct to recovery and reducing morbidity and mortality. In contrast to adults, this is especially important for pediatric patients who have limited reserves and are in a period of growth. Burn patients often require multiple anesthetic procedures that are accompanied by standard perioperative fasting periods that result in substantial nutritional interruptions. Continuous intraoperative feeding has been proposed as a solution, but there is no current consensus on its role and safety, particularly in the pediatric population. Thus, the goal of this study was to examine the safety and benefits of intraoperative nutrition in critically ill pediatric burn injured patients. A systematic review of MEDLINE, PubMed, Scopus, and Web of Science was conducted using the following terms: feeding or enteral or nutrition or fasting and adolescent or youth or pediatric or child or teen and burn or thermal injury or fire. The primary outcome was incidence of aspiration. Secondary outcomes included patient nutritional status (caloric deficit and weight), wound healing, days spent in the intensive care unit, ventilator days, pneumonia, number of surgeries, length of hospital stay, and mortality. Pooled analyses of binary outcomes were computed. Four studies consisting of 496 patients, met inclusion criteria. All studies were level IV evidence, but had high methodological quality. The median burn TBSA was 43.8% (interquartile range 33.4%–58.8%), with a median of 30% of patients having an inhalational injury. Patients underwent a median of 4.2 surgeries (interquartile range 1.8–7.4). Intraoperative feeding was conducted through nasoduodenal tubes. There were no aspiration events. Pooled analysis demonstrated that there were no differences in rates of aspiration, pneumonia, or wound infection (P &gt; .05) between patients who were intraoperatively fed and those who were not. Those fed intraoperatively had significantly more surgeries, ventilator days, longer hospital stays, but lower mortality (P &lt; .05). There was large heterogeneity in nutritional assessment methods. Intraoperatively fed patients had an average gain of 144.4 kcal/kg, 1.7 days of exclusive enteral nutrition (vs loss of −119.1 kcal/kg and −1.4 days), and a cumulative positive caloric balance of +2673 kcal ± 2147 (vs loss of −7899 kcal ± 3123) compared to those with interrupted feeding. Continuous intraoperative duodenal feeding during burn surgery appears to be safe in the pediatric burn population, with no reported episodes of aspiration. Uninterrupted feeding was also associated with weight maintenance and reduced caloric deficit. It may also have a survival benefit, as continuously fed patients needed more surgeries and intensive/hospital care, but had decreased mortality.
Quantitative Nodal Burden and Mortality Across Solid Cancers
Authors: Nguyen Anthony T , Luu Michael , Nguyen Vina P , Lu Diana J , Shiao Stephen L , Kamrava Mitchell , Atkins Katelyn M , Mita Alain C , Scher Kevin S , Spratt Daniel E , Faries Mark B , Daskivich Timothy J , Lin De-Chen , Chen Michelle M , Clair Jon Mallen-St , Sandler Howard M , Ho Allen S , Zumsteg Zachary S 
Published: March 2022

Abstract

Background
Nodal staging systems vary substantially across solid tumors, implying heterogeneity in the behavior of nodal variables in various contexts. We hypothesized, in contradiction to this, that metastatic lymph node (LN) number is a universal and dominant predictor of outcome across solid tumors.

Methods
We performed a retrospective cohort analysis of 1 304 498 patients in the National Cancer Database undergoing surgery between 2004 and 2015 across 16 solid cancer sites. Multivariable Cox regression analyses were constructed using restricted cubic splines to model the association between nodal number and mortality. Recursive partitioning analysis (RPA) was used to derive nodal classification systems for each solid cancer based on metastatic LN count. The reproducibility of these findings was assessed in 1 969 727 patients from the Surveillance, Epidemiology, and End Results registry. Two-sided tests were used for all statistical analyses.

Results
Consistently across disease sites, mortality risk increased continuously with increasing number of metastatic LNs (P &lt; .001 for all spline segments). Each RPA-derived nodal classification system produced multiple prognostic groups spanning a wide spectrum of mortality risk (P &lt; .001). Multivariable models using these RPA-derived nodal classifications demonstrated improved concordance with mortality compared with models using American Joint Committee on Cancer staging in sites where nodal classification is not based on metastatic LN count. Each RPA-derived nodal classification system was reproducible in a large validation cohort for all-cause and cause-specific mortality (P &lt; .001). High quantitative nodal burden was the single strongest tumor-intrinsic variable associated with mortality in 12 of 16 disease sites.

Conclusions
Quantitative metastatic LN burden is a fundamental driver of mortality across solid cancers and should serve as a foundation for pathologic nodal staging across solid tumors.
Trichofolliculoma of the external auditory canal: a case report and review of the literature
Authors: Saleem Matthew I , Tham Tristan , Ponder Brent , Georgolios Alexandros 
Published: March 2022

Abstract
Trichofolliculoma is a rare tumor that arises from immature hair follicular tissue. In this report, we present the case of a 51-year-old man with a trichofolliculoma in the left external auditory canal. Uniquely, there was no prior trauma in this patient, despite previous trauma being hypothesized in the etiology of this tumor. The lesion was excised using microsurgical instruments and the tumor was closely adherent to the cartilage of the external auditory canal. Histopathology following excisional biopsy confirmed the diagnosis.
A simple pipeline for cell cycle kinetic studies in the root apical meristem
Authors: Pasternak Taras , Kircher Stefan , Pérez-Pérez José Manuel , Palme Klaus 
Published: March 2022

Abstract
Root system architecture ultimately depends on precise signaling between different cells and tissues in the root apical meristem (RAM) and integration with environmental cues. This study describes a simple pipeline to simultaneously determine cellular parameters, nucleus geometry, and cell cycle kinetics in the RAM. The method uses marker-free techniques for nucleus and cell boundary detection, and 5-ethynyl-2ʹ-deoxyuridine (EdU) staining for DNA replication quantification. Based on this approach, we characterized differences in cell volume, nucleus volume, and nucleus shape across different domains of the Arabidopsis RAM. We found that DNA replication patterns were cell layer and region dependent. G2 phase duration, which varied from 3.5 h in the pericycle to more than 4.5 h in the epidermis, was found to be associated with some features of nucleus geometry. Endocycle duration was determined as the time required to achieve 100% EdU-positive cells in the elongation zone and, as such, it was estimated to be in the region of 5 h for the epidermis and cortex. This experimental pipeline could be used to precisely map cell cycle duration in the RAM of mutants and in response to environmental stress in several plant species without the need for introgressing molecular cell cycle markers.
Foliar chlorophyll concentration modulates the degree of fungal exploitation in a rhizoctonia-associated orchid
Authors: Suetsugu Kenji , Matsubayashi Jun 
Published: March 2022

Abstract
Some green orchids obtain carbon from both mycobionts and photosynthesis at the adult stage. Intriguingly, these orchids can produce albino and, in rare cases, variegated phenotypes. Here, we studied a Platanthera hondoensis population with green, variegated, and albino individuals. Although its closely related Platanthera species are usually associated with non-ectomycorrhizal rhizoctonias, and several studies have failed to find evidence of trophic plasticity in rhizoctonia-associated orchids, variegated and albino P. hondoensis must possess a higher fungal dependency than green P. hondoensis. Therefore, we investigated whether (i) P. hondoensis is associated with non-ectomycorrhizal rhizoctonias and (ii) the degree of mycoheterotrophy (using 13C abundance as a proxy) correlates with the foliar chlorophyll concentration. High-throughput DNA sequencing revealed that all P. hondoensis phenotypes were dominantly associated with a rhizoctonia from Ceratobasidiaceae belonging to a clade distinct from recognized ectomycorrhizal clades. Regression analysis revealed a positive linear relationship between foliar chlorophyll concentration and the degree of mycoheterotrophy. This study strongly suggests that rhizoctonia-associated P. hondoensis can dynamically adjust fungal exploitation in response to photosynthetic carbon levels. Since rhizoctonia is the most common orchid mycorrhizal partner, trophic plasticity may be a widespread adaptive trait in green orchids.
Pathogenic Homozygous Mutations in the DBT Gene (c.1174A&gt;C) Result in Maple Syrup Urine Disease in a rs12021720 Carrier
Authors: Alijanpour Morteza , Jazayeri Omid , Soleimani Amiri Shima , Brosens Erwin 
Published: March 2022

Abstract

Objective
Maple syrup urine disease (MSUD; OMIM #248600) is an autosomal recessive metabolic disorder in the catabolism of branched-chain amino acids (leucine, isoleucine, and valine) and may be lethal if untreated in affected newborns.

Methods
Single-nucleotide polymorphism haplotyping and Sanger sequencing of BCKDHA, BCKDHB, and DBT genes were performed in a cohort of 10 MSUD patients.

Results
We identified a 16.6 Mb homozygous region harboring the DBT gene in an Iranian girl presenting with MSUD. Sanger sequencing revealed a pathogenic homozygous variant (NM_001918.3: c.1174A &gt; C) in the DBT gene. We further found a controversial variant (rs12021720: c.1150 A &gt; G) in the DBT gene. This substitution (p.Ser384Gly) is highly debated in literature. Bioinformatics and cosegregation analysis, along with identifying the real pathogenic variants (c.1174 A &gt; C), lead to terminate these various interpretations of c.1150 A &gt; G variant.

Conclusion
Our study introduced c.1150 A &gt; G as a polymorphic variant, which is informative for variant databases and also helpful in molecular diagnosis.
Influenza Vaccine Booster Stimulates Antibody Response in Beta Thalassemia Major Patients
Authors: Sheikh Maryam , Ahmadi-Vasmehjani Abbas , Atashzar Mohammad Reza , Karbalaie Niya Mohammad Hadi , Ebrahimian Arefeh , Baharlou Rasoul 
Published: March 2022

Abstract
The aim of this study was to evaluate antibody response against influenza vaccine in beta thalassemia major patients from Iran. Thirty beta thalassemia major patients were enrolled and divided into three groups: single dose (group 1), double dose (group 2), and control (group 3). Seroconversion, seroprotection, and geometric mean titer (GMT) assays were performed through hemagglutination inhibition (HI) on days 0, 14, and 60. Based on the results, the level of antibody titer was increased in group 2. Two weeks after vaccination, seroconversion rate was about 20% and 30% in groups 1 and 2. Sixty days after vaccination, the seroconversion rate was around 70% and GMT showed a more than 2-fold increase in group 2. Based on the results, the immunogenicity of double dose vaccination against influenza infection appears to be higher than the single dose vaccine in beta thalassemia major patients, and thus it is recommended to use two doses of vaccine, especially in splenectomized patients who are more sensitive than others.
In Search of Carl Czerny’s Schemata: Listening to Early Nineteenth-Century Improvisation
Authors: Rabinovitch Gilad 
Published: March 2022

AbstractThis article analyzes Carl Czerny’s exemplars for fantasizing in Systematische Anleitung zum Fantasieren auf dem Pianoforte (1829). I argue that a musical prototype combining scale-degree schemata (Meyer 1980, Gjerdingen 2007) and sentential features (Caplin 1998) emerges as an implicit knowledge structure in several of Czerny’s notated musical examples that demonstrate how to react to a given theme for improvisation. Through an examination of notated fantasies recommended by Czerny as models for extemporizing, I propose a beginning-of-fantasy prototype, which allows us to discern improvisatory qualities in Beethoven’s notated “artworks” such as the Tempest sonata, the Appassionata, and others.
Blood exosomes-based targeted delivery of cPLA2 siRNA and metformin to modulate glioblastoma energy metabolism for tailoring personalized therapy
Authors: Zhan Qi , Yi Kaikai , Cui Xiaoteng , Li Xueping , Yang Shixue , Wang Qixue , Fang Chuan , Tan Yanli , Li Lijie , Xu Can , Yuan Xubo , Kang Chunsheng 
Published: March 2022

Abstract

Background
Targeting glioblastoma (GBM) energy metabolism through multiple metabolic pathways has emerged as an effective therapeutic approach. Dual inhibition of phospholipid and mitochondrial metabolism with cytoplasmic phospholipase A2 (cPLA2) knockdown and metformin treatment could be a potential strategy. However, the strategic prerequisite is to explore a carrier capable of co-delivering the therapeutic combination to cross the blood-brain barrier (BBB) and preferentially accumulate at the GBM site.

Methods
Blood exosomes (Exos) were selected as the combination delivery carriers. The cellular uptake of Exos and the therapeutic effects of the combination strategy were evaluated in primary GBM cells. In vivo GBM-targeted delivery efficiency and anti-GBM efficacy were tested in a patient-derived xenograft (PDX) model.

Results
Here, we showed that the Exos-mediated cPLA2 siRNA/metformin combined strategy could regulate GBM energy metabolism for personalized treatment. Genomic analysis and experiments showed that polymerase 1 and transcript release factor (PTRF, a biomarker of GBM) positively regulated the uptake of Exos by GBM cells, confirming the feasibility of the delivery strategy. Further, Exos could co-load cPLA2 siRNA (sicPLA2) and metformin and co-deliver them across the BBB and into GBM tissue. The mitochondrial energy metabolism of GBM was impaired with this combination treatment (Exos-Met/sicPLA2). In the PDX GBM model, systemic administration of Exos-Met/sicPLA2 reduced tumor growth and prolonged survival.

Conclusions
Our findings demonstrated that Exos-based combined delivery of sicPLA2 and metformin selectively targeted the GBM energy metabolism to achieve antitumor effects, showing its potential as a personalized therapy for GBM patients.
Secondhand Aerosol Exposure From Heated Tobacco Products and Its Socioeconomic Inequalities in Japan: The JASTIS Study 2017–2020
Authors: Tamada Yudai , Takeuchi Kenji , Okawa Sumiyo , Tabuchi Takahiro 
Published: March 2022

Abstract

Introduction
The growing use of heated tobacco products (HTPs) has raised concerns about secondhand aerosol (SHA) from HTPs, but few studies have been reported on it. This study aimed to investigate the trends in SHA exposure and their socioeconomic inequalities in Japan.

Methods
The prevalence of SHA exposure from 2017 to 2020 was estimated using longitudinal internet survey data of 5221 participants, aged 20–69 years in 2017 (baseline), with adjustments using inverse probability weighting for “being a participant in an internet survey”. Multivariable modified Poisson regression models were applied to examine the association between socioeconomic status (ie, educational attainment and equivalent income) at baseline and SHA exposure in 2020 with adjustments for sex and age.

Results
The estimated prevalence of SHA exposure has consistently increased from 4.5% in 2017 to 10.8% in 2020. Lower educational attainment was associated with a higher risk of SHA exposure (p for trend = 0.010). The covariate-adjusted risks of SHA exposure in participants with a low-education and middle-education level were 1.57 and 1.34 times higher, respectively, than in those with a high-education level. However, significant differences in risks of SHA exposure between participants with low-, middle-, and high-income levels were not observed. Meanwhile, participants with a low-education and middle-education level also had 1.87 and 1.61 times higher risks of secondhand smoke (SHS) exposure from combustible cigarettes than those with a high-education level, respectively.

Conclusions
Our study revealed a rapid increase in SHA exposure and the existence of educational inequalities in both SHA and SHS exposure.

Implications
Using longitudinal internet cohort survey data, we found that the prevalence of exposure to secondhand aerosol (SHA) from heated tobacco products (HTPs) rapidly increased to 10.8% in 2020 in Japan. Furthermore, people with lower educational attainment were at higher risk of SHA exposure, suggesting that extensive educational interventions may be necessary to inform the public that although emissions from HTPs contain significantly lesser amounts of harmful and potentially harmful constituents and these compounds than cigarette smoke, they are not harmless and still entail risks, and its long-term effects are unknown. Therefore, future extensive monitoring of SHA exposure is needed.
The Incidence of Ocular Complications in Candidemic Patients and Implications for the Practice of Routine &#x2028;Eye Exams
Authors: Hillenbrand Molly , Mendy Angelico , Patel Kavya , Wilkinson Racheal , Liao Siyun , Robertson Jamie , Apewokin Senu 
Published: March 2022

Abstract

Background
Ocular candidiasis is a known complication of candidemia. Given the poor ocular penetration of echinocandins, there is some concern that the increasing use of echinocandins may portend an increased incidence of ophthalmic complications. We examined the changing trends in antifungal prescribing patterns and the incidence of ophthalmic complications after candidemia.

Methods
Patients with blood cultures positive for Candida species between January 2014 and June 2020 who underwent screening fundoscopic examination by an ophthalmologist were analyzed. The χ2 analysis was used to compare antifungal prescriptions and ocular exam findings before and after 2016. Trend analysis was also performed to assess temporal changes in prescribing practices and eye exam findings.

Results
There were 226 candidemia cases during the study period, 129 (57.1%) of which underwent screening eye exams. From 2014 to 2015, 24 of 37 (64.5%) patients received eye-penetrating antifungals compared to 36 of 92 (39.1%) from 2016 to 2020 (P = .008). Overall, 30 of 129 (23.3%) patients had abnormal eye exams with the prevalence of abnormal findings being 7 of 37 (18.9%) before 2016 compared to 23 of 92 (25%, P = .46) thereafter. A trend analysis revealed an increase in abnormal eye findings over the study period (P = .008). Of the 30 patients who had abnormal eye exams, 9 (30%) had a change in systemic antifungal therapy from echinocandins to eye-penetrating antifungals. Echinocandin use was associated with abnormal eye findings.

Conclusions
Prescription of eye-penetrating antifungals for candidemia has trended down since 2016. This was associated with a concomitant increase in abnormal findings on screening fundoscopy. Abnormal eye exams were not uncommon throughout our study period.
“Provide our basic needs or we go out”: the COVID-19 pandemic lockdown, inequality, and social policy in Ghana
Authors: Foli Rosina K , Ohemeng Frank L K 
Published: March 2022

Abstract
The effects of the coronavirus disease (COVID-19) pandemic cuts across every facet of a nation’s life. The near collapse of economies with the attendant job losses has brought forth the need for effective social policies, particularly in developing countries, that can serve citizens in dire need. Consequently, many of these countries have had to craft emergency social policies to help their citizens. Ghana is no exception. While measures to control the spread of the pandemic, such as lockdowns and restrictions on movement and gathering, were timely, they negatively impacted the poor, most of whom work in the informal sector and depend on daily survival activities such as buying and selling basic goods. As a result, some of the measures were ignored as people feared they would die from hunger rather than from the pandemic. Thus, governmental response to the pandemic was highlighted by policy layering and exposed the fragile social support systems in existence. The challenges of responding adequately to the pandemic underscore the importance of a transformative social welfare regime in ensuring the protection of citizens. This paper, based on desk research, explores the limitations of the existing social policy framework, which became manifest during the implementation of Ghana’s pandemic policies. Policy layering by government continues to weaken Ghana’s social welfare system, and this affected the official response with respect to the social issues that have emerged due to the pandemic.
Conditions of naturalness and fine-tuning for the type-I seesaw mechanism with four-zero texture
Authors: Yang Masaki J S 
Published: March 2022

Abstract
In this paper, we search for conditions under which the mass matrix of light neutrinos mν is not a result of large cancellations for the type-I seesaw mechanism with four-zero texture. For the Yukawa matrix of neutrinos Yν and heavy Majorana mass matrix MR, these conditions are written as $(Y_{\nu })_{i2} \propto (m_{\nu })_{i2} \Rightarrow (Y_{\nu })_{i2} \propto (M_{R})_{i2}$. We call them alignment conditions because they align certain rows or columns of the three neutrino mass matrices. If these conditions do not hold, the large mixing in mν is a result of fine-tuning due to the cancellation of several terms. Then they are required from the viewpoint of naturalness. They give an explanation of the seesaw invariance of four-zero texture, and place rough restrictions on flavor structures of neutrinos. Under these conditions, Yν must have a cascade hierarchy. For MR, the 12 submatrix has a similar hierarchy to Yν and mν. However, the 23 submatrix has a waterfall hierarchy without some fine-tuning. Therefore, it is likely that Yν and MR have qualitatively different flavor structures. Furthermore, since the conditions restrict CP phases of the matrix elements, they imply the existence of a universal generalized CP symmetry in the neutrino sector.