bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative analysis of ecological risk and human health risk of potentially toxic elements in farmland soil using the PMF model
Authors: Huang Chang‐Chen , Cai Li‐Mei , Xu Yao‐Hui , Wen Han‐Hui , Jie Luo , Hu Guo‐Cheng , Chen Lai‐Guo , Wang Han‐Zhi , Xu Xu‐Bang , Mei Jing‐Xian 
Published: March 2022

AbstractPotentially toxic element (PTE) pollution in farmland soil is a global problem. It is vital to clarify the contributions of farmland soil PTE from different sources to potential ecological risk (PER) and human health risks (HHR), but the existing research methods were incomplete. This study explored a comprehensive scheme that combined source contribution and risk assessment to quantitatively assess PER, HHR and the priority pollution sources. enrichment factor (EF) and pollution load index (PLI) were utilized to estimate the features of enrichment and contamination of PTE in farmland soil. Furthermore, spatial distribution characteristics of PTE and positive matrix factorization (PMF) were combined to distinguish and ascertain the sources of PTE, and the PER and HHR model based on PMF were applied to evaluate the ecological and human health risks in different sources. Taking Puning District as an example, four sources of farmland soil PTE were quantitatively allocated. For ecological risk, the study area was at moderate ecological hazard, with industrial activities (53.67%) contributing the most. The mean of Hg was 69.82, reaching medium ecological risk. For human health risks, both adults and children had no non‐carcinogenic risk in the study area, and the natural source was the greatest contributor, followed by agricultural activities. The total carcinogenic risk index (TCRI) values for adults and children were 1.40E‐05 and 2.75E‐05, respectively, showing no significant carcinogenic risk. Furthermore, compared with adults, the health risks of children, whether non‐carcinogenic or carcinogenic, were higher than those of adults.
Analysis of the epidermal growth factor receptor/phosphoinositide‐dependent protein kinase‐1 axis in tumor of the external auditory canal in response to epidermal growth factor stimulation
Authors: Akiyama Naotaro , Yamamoto‐Fukuda Tomomi , Yoshikawa Mamoru , Kojima Hiromi 
Published: March 2022

AbstractObjectivesThe epidermal growth factor receptor (EGFR) is related to the invasion and metastasis of external auditory canal (EAC) squamous cell carcinoma (SCC). The phosphoinositide‐dependent protein kinase‐1 (PDPK1) accelerates tumor cell growth through anti‐apoptotic signaling under the influence of downstream EGFR‐mediated signaling pathways. In this study, we investigated the EGFR/PDPK1 axis in the EAC under EGF stimulation.MethodsWe confirmed EGFR and PDPK1 expression in human EACSCC specimens immunohistochemically. We next transfected the EGF expression vector in the mouse EAC and then conducted a PDPK1 inhibitory experiment. Immunohistochemical analysis was performed in the mouse EAC, using anti‐EGF, anti‐EGFR, anti‐PDPK1, and anti‐Ki67 antibodies. Immunohistochemical analysis of cleaved caspase‐3 and terminal deoxy(d)‐UTP nick end labeling (TUNEL) detection assays were also performed for the assessment of apoptosis in the inhibitory experiment.ResultsImmunohistochemical analysis revealed overexpression and colocalization of EGFR and PDPK1 in human EACSCC specimens. The growth of a protuberant tumor was observed in the mouse EAC in which EGF expression vector was transfected, and EGF, EGFR, PDPK1, and Ki67 labeling indexes (LIs) were significantly increased. PDPK1 inhibition then induced normal epithelial appearance in the EAC. Moreover, EGF, EGFR, PDPK1, and Ki67 LIs were decreased, and cleaved caspase‐3 and TUNEL LIs were increased in the EAC.ConclusionWe demonstrated the possibility that PDPK1 plays an important role in EACSCC.Level of Evidence: NA.
Prognostic value of pretreatment lymphocyte‐to‐monocyte ratio in patients with advanced oral cavity cancer
Authors: Supanimitjaroenporn Pasawat , Kirtsreesakul Virat , Tangthongkum Manupol , Leelasawatsuk Peesit , Prapaisit Usaporn 
Published: March 2022

AbstractIntroductionLymphocyte‐to‐monocyte ratio (LMR) has been reported as a prognostic factor in many cancers but the data are to date limited for its use in oral cavity cancer. The purpose of this study was to evaluate the prognostic value of LMR in advanced‐stage oral cavity cancer.MethodsData from 211 advanced‐stage oral cancer patients treated with curative intent between January 2009 and December 2015 were obtained from the hospital information system. Pretreatment LMR and other hematologic parameters were recorded and an LMR cutoff value was calculated. Overall survival between the groups above (high LMR) and below (low LMR) the cutoff was compared and hazard ratios from univariate and multivariate analyses using a Cox proportional hazards model calculated.ResultsOverall survival and disease‐specific survival were better in the high LMR group. The 5‐year overall survival rates were 31.6% and 15% in the high LMR and low LMR groups, respectively. Multivariate analysis using a Cox proportional hazards model showed that treatment modality and LMR were the only factors associated with overall survival.ConclusionLow LMR was associated with poor survival outcome in patients with advanced‐stage oral cavity cancer.Level of Evidence2b.
The effect of brand crises on endorser reputation and endorsement portfolios
Authors: Johnson Clark D. , Bauer Brittney C. , Arnold Mark J. 
Published: March 2022

AbstractWe often hear about a brand dropping a celebrity after the endorser has negative publicity. However, endorsers are not the only ones who are responsible for negative news; many brands also generate negative publicity as well. The growing frequency of brand crises and the demonstrated relationship between brand‐ and endorser‐reputation begs the question: What impact might a severe brand crisis have on a celebrity endorser's reputation and endorsement portfolio? Study 1 finds that negative publicity only impacts the brand's moral reputation if internal locus attributions are made. In turn, moral reputation positively impacts attitudes toward the brand, endorser, and other brands in their endorsement portfolio. Next, Study 2 discovers that endorsers may be perceived to have greater authenticity, leading to more favorable consumer attitudes, if they “drop” the offending brand. Finally, Study 3 finds that “dropping” the offending brand can mitigate negative spillover effects on attitudes toward bystander brands.
Ultrafast control of moiré pseudo‐electromagnetic field in homobilayer semiconductors
Authors: Zhai Dawei , Yao Wang 
Published: March 2022

AbstractIn long‐wavelength moiré patterns of homobilayer semiconductors, the layer pseudospin of electrons is subject to a sizable Zeeman field that is spatially modulated from the interlayer coupling in moiré. By interference of this spatial modulation with a homogeneous but dynamically tunable component from an out‐of‐plane electric field, we show that the spatial‐temporal profile of the overall Zeeman field therefore features a topological texture that can be controlled in an ultrafast timescale by a terahertz field or an interlayer bias. Such dynamical modulation leads to the emergence of an in‐plane electric field for low‐energy carriers, which is related to their real space Berry curvature—the moiré magnetic field—through Faraday's law of induction. These emergent electromagnetic fields, having opposite signs at the time reversal pair of valleys, can be exploited to manipulate valley and spin in the moiré landscape under the control of a bias pulse or terahertz irradiation.Key Points
Temporal control of topological texture through the interference of spatial and temporal modulations.
Emergent electromagnetic fields in nanoscale that can be manipulated in picosecond timescale.
Pulsed spin and valley pseudospin current controlled by electrical bias or terahertz irradiation.
Oncologist counseling practice and COVID‐19 vaccination outcomes for patients with history of PEG‐asparaginase hypersensitivity
Authors: Zarnegar‐Lumley Sara , Stone Cosby A. , Smith Christine M. , Hall Laura L. , Luck Kate E. , Koo Grace , Plager Jessica H. , Phillips Elizabeth J. , Friedman Debra L. 
Published: March 2022

AbstractVaccination against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is an effective strategy to prevent serious coronavirus disease 2019 (COVID‐19) and is important for oncology patients. mRNA‐based COVID‐19 vaccines are contraindicated in those with a history of severe or immediate allergy to any vaccine component, including polyethylene glycol (PEG)2000. Patients with acute lymphoblastic leukemia/lymphoma receive asparaginase conjugated to PEG5000 (PEG‐ASNase) and those with PEG‐ASNase‐associated hypersensitivity may be unnecessarily excluded from receiving mRNA COVID‐19 vaccines. We, therefore, surveyed oncologists on COVID‐19 vaccine counseling practice and vaccination outcomes in COVID‐19 vaccination‐eligible patients and show safe receipt of mRNA vaccines despite PEG‐ASNase hypersensitivity.
Prominence of quantitative fiber loading on free vibration, damping behavior, inter‐laminar shear strength, fracture toughness, thermal conductivity, and flammability properties ofjute–bananahybrid fiber phenol‐formaldehyde composites
Authors: B. H. Maruthi Prashanth , Gouda P. S. Shivakumar , Manjunatha T. S. , Edacheriane Abhilash , Umarfarooq M. A. 
Published: March 2022

AbstractThe primary purpose of this study is to realize quantitative fiber loading effects on free vibration, damping behavior, fracture toughness, thermal conductivity, inter‐laminar shear strength, and flammability of jute–banana fiber phenol‐formaldehyde (PF) hybrid composites. These composites were manufactured with fiber weight percentages ranging from 30% to 60% using hot press technique. Hybrid composite with equal amount of fiber and resin (PJB‐2) had a higher natural frequency in the range of 4.8%–59%, a higher inter‐laminar shear strength varying from 30% to 54%, a higher fracture toughness with minimum of 19 to maximum of 44%, and a low damping factor in the range of 25%–59% to that of other composite having unequal amount of fiber and resin loading. In contrast to other composites, the composite containing 30 wt% fiber (PJB‐4) has a high heat conductivity of about 10%–20%. However, the thermal conductivity of jute–banana fiber PF composites declined as the fiber content increased beyond 30 wt%, while the flame resistance was improved as the resin concentration increased. Additionally, Scanning electron microscopy (SEM) studies clearly indicates the failure patterns of fiber matrix interface under Inter laminar shear strength and fracture toughness tests were supports to justify the experimental results.
Sustainable alginate/aloe vera composite biodegradable films reinforced with carboxymethyl cellulose and hydroxypropyl methylcellulose
Authors: Hadi Alina , Nawab Anjum , Alam Feroz , Zehra Kishwar 
Published: March 2022

AbstractBiopolymers like polysaccharides are being used to develop biodegradable and edible food packaging films. These films are environment friendly but have inferior mechanical strength as compared to conventional plastics. This study seeks to enhance the mechanical properties of alginate aloe vera composite films by the fusion of organic fibers like carboxymethyl cellulose (CMC) and hydroxypropyl methylcellulose (HPMC). CMC and HPMC were added at varying concentrations (2%–14%).Addition of both these cellulose derivatives had a positive effect on the tensile strength and elongation at break of the composite films. The tensile strength increased to a maximum value of 35.08 and 51.96 N/mm2 in CMC and HPMC films, respectively at 4% concentration of both. Increasing the fiber concentration further resulted in a decrease of tensile strength. Similar trend was observed in the flexibility of the films as the elongation at break value was maximum 5.57% and 3.21%, respectively at 4% concentration. The addition of CMC reduced the water solubility of the film. The solubility decreased to 19% at the maximum concentration of CMC. The effect of HPMC on water solubility was opposite to that of CMC. The solubility of the film increased to 86.42% at highest concentration of HPMC. CMC slowed down the biodegradation rate of the films whereas HPMC increased it.
Incorporating psychosocial care into routine oncological care: Insights into challenges and strategies from certified cancer centers' audit data
Authors: Breidenbach Clara , Kowalski Christoph , Ansmann Lena , Schult Sarah , Sibert Nora Tabea , Neupert Ingo , Zimmermann Tanja , Wesselmann Simone 
Published: March 2022

AbstractPurposeProvision of psychosocial care is obligatory in cancer centers certified in accordance with the criteria of the German Cancer Society, but the extent to which it is utilized differs greatly between centers. Anomalous utilization percentages are discussed during certification audits. This analysis aims to describe (1) how certified centers explain psychosocial care utilization percentages during audits and (2) the measures they then plan for improving psychosocial care utilization. The aim of the analysis is to help understand patterns of psychosocial care utilization in oncology and reduce potential disparities by describing the challenges that cancer centers face and their strategies for integrating psychosocial care into routine oncological care.MethodsThe content of free‐text comments regarding psychosocial utilization percentages by certified centers during certification audits in 2019 was analyzed. In total, 178 comments were analyzed from 116 prostate, colorectal, and breast cancer centers in Germany, Switzerland, Austria, Italy, and Luxembourg.ResultsThe explanations for utilization percentages most often mentioned involved patients' levels of interest and need, outpatient care, staff shortages, inclusion of psychosocial care in other processes in the center, documentation issues, and factors regarding different legal regulations in countries outside Germany. The measures most often planned for improving psychosocial care utilization involved adjusting work processes, increasing staff resources, optimizing documentation, and establishing quality‐assurance groups/task forces.ConclusionThis exploratory analysis shows that the challenges and strategies involved in incorporating psychosocial care into routine oncological care are diverse. Further research should identify process‐level strategies that can promote the integration of psychosocial care.
Synthesis and Aggregation‐Induced Emission of Polyamide‐Amines as Fluorescent Switch Controlled by Hg2+‐Glutathione
Authors: Zhao Ronghui , Zheng Jinxin , Chen Zhuo , Wang Meng , Zhang Da , Ding Lan , Fu Congcong , Zhang Chunfang , Deng Kuilin 
Published: March 2022

AbstractIn this study, a series of polyamide‐amines (PAAs) were prepared by Michael addition reaction of piperazine derivatives with N, N‐bisacrylamidepiperazine (BAP). An obvious aggregation‐induced emission (AIE) effect was observed for PAAs with fluorescence emission at 425–525 nm and affected by the structure, excitation wavelength, pH value, temperature, PAAs concentration and precipitant (acetone). The piperazine rings and amides groups on PAAs backbone contribute to their AIE by the clusterization‐triggered emission (CTE) mechanism, in accordance with the red‐shift of time‐dependent density functional theory (DFT). The DFT results proved the influence of packing way on aggregation luminescence, clarified the cluster mechanism of luminescences, and the ultraviolet absorption spectrum of PAAs. Additionally, based on the coordination, Hg2+ ions effectively quenched the fluorescence intensity of PAAs and showed enhanced quenching effect with the increase of concentration of Hg2+ ions. And also, a reducing agent, glutathione, can restore the fluorescence of PAAs solution mixed with Hg2+ ions, by which realizes the reversible switching process between fluorescence on and fluorescence off.
A Tuning‐Fork Triboelectric Nanogenerator with Frequency Multiplication for Efficient Mechanical Energy Harvesting
Authors: Liu Nian , Liu Di , Gao Yikui , Li Shaoxin , Zhou Linglin , Zhao Zhihao , Cui Shengnan , Liu Lu , Wang Zhong Lin , Wang Jie 
Published: March 2022

AbstractAs a new technology for high‐entropy energy harvesting, a triboelectric nanogenerator (TENG) has broad applications in sensor networks and internet of things as a power source, but its average power density is limited by the fixed low‐frequency output. Here, a frequency‐multiplication TENG based on intrinsic high frequency of tuning fork is proposed which enables converting low‐frequency mechanical energy into high‐frequency electric energy. A tuning‐fork TENG is used to systematically study the effects of intrinsic frequency, dielectric's thickness, and gap distance on its electric performance, and a total transferred charges of 4.3 µC and an average power density of 9.42 mW m–2 are realized at the triggering frequency of 0.2 Hz, which are 71 times and 5.7 times than that of the single‐cycle output of conventional contact‐separation TENG, respectively. Moreover, the crest factor also decreases from 3.5 to around 1.5. Then, a homemade tuning fork‐like TENG is reasonably designed for harvesting ambient wind energy, achieving an average power density of 20.02 mW m–2 at a wind speed of 7 m s–1. Specially, its impedance resistance is independent of the mechanical triggering frequency, simplifying the back‐end power management circuit design. Therefore, the frequency‐multiplication TENG shows a great potential for efficient distributed energy harvesting.
Strategies for Enhancing Vascularization of Biomaterial‐Based Scaffold in Bone Regeneration
Authors: Nambiar Jasna , Jana Sonali , Nandi Samit Kumar 
Published: March 2022

AbstractDespite the recent advances in reconstructive orthopedics; fracture union is a challenge to bone regeneration. Concurrent angiogenesis is a complex process governed by events, delicately entwined with osteogenesis. However, poorly perfused scaffolds have lower success rates; necessitating the need for a better vascular component, which is important for the delivery of nutrients, oxygen, waste elimination, recruitment of cells for optimal bone repair. This review highlights the latest strategies to promote biomaterial‐based scaffold vascularization by incorporation of cells, growth factors, inorganic ions, etc. into natural or synthetic polymers, ceramic materials, or composites of organic and inorganic compounds. Furthermore, it emphasizes structural modifications, biophysical stimuli, and natural molecules to fabricate scaffolds aiding the genesis of dense vascularization following their implantation to manifest a compatible regenerative microenvironment without graft rejection.
Second‐order nonlinear polarizability of “Push‐Pull” chromophores. A decade of progress in donor‐π‐acceptor materials
Authors: Kaur Paramjit , Singh Kamaljit 
Published: March 2022

AbstractFine tuning and switching of nonlinear optical response of ferrocene chromophores has been an area of considerable significance as evidenced by a large number of reports in the current literature. In this personal account, we present linear/nonlinear behavior and structure‐activity relationships of several classes of donor‐π‐acceptor designs using organometallic and organic materials, developed by our research group during the last decade. The results especially the electronic absorption spectral and the hyper‐Rayleigh scattering have been supported by theoretical calculations. Exploiting the redox behavior of ferrocene donor, we have demonstrated switching of quadratic nonlinear optical responses with reversible redox chemistry, which is a useful attribute of nonlinear optical materials. Based on the ease in synthesis, structure diversification and structure‐based large and switchable second‐order optical nonlinearity, these materials are potential candidates for electro‐optic applications.
Stillbirth due to SARS‐CoV‐2 placentitis without evidence of intrauterine transmission to fetus: association with maternal risk factors
Authors: Konstantinidou A. E. , Angelidou S. , Havaki S. , Paparizou K. , Spanakis N. , Chatzakis C. , Sotiriadis A. , Theodora M. , Donoudis C. , Daponte A. , Skaltsounis P. , Gorgoulis V. G. , Papaevangelou V. , Kalantaridou S. , Tsakris A. 
Published: March 2022

AbstractObjectivesTo describe the placental pathology, fetal autopsy findings and clinical characteristics of pregnancies that resulted in stillbirth owing to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) placentitis, and to identify potential risk factors.MethodsThis was a prospective multicenter study of non‐vaccinated pregnant women affected by coronavirus disease 2019 (COVID‐19) in Greece from April 2020 to August 2021. A total of 165 placentas were examined histologically and six cases of stillbirth associated with SARS‐CoV‐2 placentitis were retrieved. Complete fetal autopsy was performed in three of these cases. Gross, histopathological, immunohistochemical, molecular and electron microscopy examinations were carried out in the stillbirth placentas and fetal organs. The histological findings of cases with SARS‐CoV‐2 placentitis were compared with those in 159 cases with maternal COVID‐19 which resulted in a live birth. Regression analysis was used to identify predisposing risk factors for SARS‐CoV‐2 placentitis.ResultsThe placentas of all six stillborn cases showed severe and extensive histological changes typical of SARS‐CoV‐2 placentitis, characterized by a combination of marked intervillositis with a mixed inflammatory infiltrate and massive perivillous fibrinoid deposition with trophoblast damage, associated with intensely positive immunostaining for SARS‐CoV‐2 spike protein, the presence of virions on electron microscopy and positive reverse‐transcription polymerase chain reaction test of placental tissues. The histological lesions obliterated over 75% of the maternal intervillous space, accounting for intrauterine fetal death. Similar histological lesions affecting less than 25% of the placenta were observed in seven liveborn neonates, while the remaining 152 placentas of COVID‐19‐affected pregnancies with a live birth did not show these findings. Complete fetal autopsy showed evidence of an asphyctic mode of death without evidence of viral transmission to the fetus. The mothers had mild clinical symptoms or were asymptomatic, and the interval between maternal COVID‐19 diagnosis and fetal death ranged from 3 to 15 days. Statistically significant predisposing factors for SARS‐CoV‐2 placentitis included thrombophilia and prenatally diagnosed fetal growth restriction (FGR). Multiple sclerosis was seen in one case.ConclusionsSARS‐CoV‐2 placentitis occurred uncommonly in COVID‐19‐affected pregnancies of non‐vaccinated mothers and, when extensive, caused fetal demise, with no evidence of transplacental fetal infection. Thrombophilia and prenatally detected FGR emerged as independent predisposing factors for the potentially lethal SARS‐CoV‐2 placentitis. © 2022 International Society of Ultrasound in Obstetrics and Gynecology.