bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical, pathological and molecular predictors of Fulvestrant long-term benefit in Hormone Receptor-positive / HER2 negative advanced breast cancer
Authors: Torrisi Rosalba , Vaira Valentina , Giordano Laura , Destro Annarita , Basilico Vera , Mazzara Saveria , Salvini Piermario , Gaudioso Gabriella , Fernandes Bethania , Rudini Noemi , Masci Giovanna , Santoro Armando 
Published: January 2022

Abstract
Purpose: The identification of factors predicting the benefit of treatments is a major goal for medical oncologists. Methods We retrospectively investigated in metastatic tumor tissues of women treated with fulvestrant for HR+/HER2 negative advanced breast cancer clinical, pathological and molecular features associated with long-term benefit from treatment defined as being progression-free at 18 months. Specifically, we analyzed ESR1 and PI3KCA mutations and miRNA profiles.Results: Fifty-nine patients were evaluable (median age 67 yrs, range 32-92). Overall mPFS was 10.7 months (range 2.2-14) while 18-month PFS rate was 27%; only the lack of visceral metastases significantly predicted the likelihood of being progression-free at 18 months (OR=0.25 95%CI 0.07-0.9 p=.035). PI3KCA mutations were found in 36% of patients and were associated with a numerically shorter mPFS but not with a lower likelihood of being progression-free at 18 months. As of miRNAs, miR-549a, miR-644a, miR-16-5p were negatively associated with 18-month PFS while let-7c-5p was positively associated with outcome. In addition, miR-520d-3p and miR-548g-3p values were significantly lower while miR-603, miR-181a and miR-199a-miR-199b-3p values were significantly higher in patients achieving 18-month PFS. In silico analysis of predicted targets suggested that miR-520d-3p and miR-548g-3p decrease might induce Hippo and Wnt signaling, while high levels of miR-603, mir-181a-5p,miR-199a-miR-199b-3p might repress endocrine resistance thus potentially promoting the response to treatment. Conclusions: Our clinical findings are consistent with literature data, while the mutation and miRNA results provide some clues on the molecular mechanisms involved in fulvestrant activity and resistance to be confirmed in larger cohorts of breast cancer patients.
Developing Entrustable Professional Activities for Doctoral Graduates in Health Professions Education: Obtaining a National Consensus in Iran
Authors: Zaeri Reza , Gandomkar Roghayeh 
Published: January 2022

Abstract
Background

The number of doctoral programs in health professions education (HPE) is expanding. Entrustable professional activities (EPAs) can be a mechanism to define the expected activities of the HPE doctorate to inform training and assessment processes. The purpose of this study was to develop and reach a consensus on EPAs for HPE doctoral graduates.
Methods

We used a modified Nominal Group Technique (NGT) to elicit EPA titles followed by two rounds of a modified Delphi survey to seeking consensus on the EPAs among groups of experts (HPE doctoral graduates and Board of Health Professions Education Examiners members) at the national level in Iran between July 2019 and July 2020.
Results

A total number of 92 initial EPA titles, which emerged from brainstorming in the NGT meeting, was reduced to 27 titles during the abstraction process. The final EPA framework consisted of 24 EPA titles with descriptions, arranged in three categories: Research and scholarship (6 EPAs); Educational development (11 EPAs); and Educational management (7 EPAs). All final EPAs scored ≥ 80% agreement at the national level.
Conclusions

The proposed EPAs framework can be used to improve the HPE doctorate training and to inform employment decisions. A future international consensus procedure could use these EPA outcomes as a starting point.
Primary Ventricular Fibrillation as The First Presentation of Aortic Dissection: A Case Report
Authors: Gheshlaghi Mehran , Mohammadi Elahe , Masroor Mojgan Javedani , Sheibani Hossein 
Published: January 2022

Abstract
This study is about an infrequent first presentation of Aortic Dissection (AD), and it is primary Ventricular Fibrillation (VF). We present a 64-year-old woman with a history of hypertension who came with sudden retrosternal chest pain, dizziness, nausea, and vomiting. The patient suffered a cardiac arrest a few seconds after admission. Cardiopulmonary resuscitation (CPR) was done for her. An electrocardiogram (ECG) showed ST elevation that demonstrated acute anterior MI (Myocardial Infarction). Trans-thoracic echocardiography (echo) CT angiography demonstrated decreased left ventricular ejection fraction with normal LV size (LVEF=25%) and type A Stanford and type I DeBakey aortic dissection flap from root up to distal of abdominal Aorta. This is while the patient's first presentation was VF, and she had anterior MI, which is unusual for aortic dissection. Therefore, we must consider AD in patients with VF. We have to consider AD in anterior MI patients because of the contraindication of medication.
Elaboration of quality perception instrument of remote teaching amidst COVID-19 pandemics in a University of Northern Brazil.
Authors: Fernandes Rafael da Silva , Luz Rosana Maria do Nascimento , Reis Daniela Castro dos , Luz Marcos Augusto Lima da , Guimarães Gabriella Vitorino 
Published: January 2022

Abstract
COVID-19 (SARS-CoV-2) pandemics changed social dynamics in several aspects, the introduction of containment measures to ensure social distancing was one of these changes, it made education institutions adopt the remote learning system. In order to understand the impact on the leaning process, this paper aims at devising and developing a measurement instrument to quantify students’ perception regarding the adaptation to the remote education provided by the Federal University of Amazonas – UFRA, over classroom-based learning, which was adopted previously to the COVID-19 context, that being the latent trait to be measured. For this purpose, theoretical procedures from the Construction Model for Psychological Tests and Measures and the psychological evaluation incorporated multiple perspectives. To validate the content, the study set three phases: 1) initial construction of the measurement instrument and literature review; 2) establishment of student focus groups; 3) judge’s analyses to outline factors and potential items. Finally, the instrument presented to the content validity index an average acceptance of 94.16% per item, and acceptance values of over 93.43% to factors and domains.
Identification of potent novel biomarkers related to Osteoporosis through bioinformatics approach
Authors: Khusboo  , Bhushan Ravi , Kusum Kusum , Dubey Pawan K. , More Raghunath S 
Published: January 2022

Abstract
Objective

Calcium is fundamental component of bone tissue. It is present in extracellular fluid in ionized form, some are bounded with albumin while a few are of the complex anionic form. Calcium regulates many biochemical processes. Loss of calcium causes hypocalcemia further lead to osteopenia and osteoporosis. Proton pump inhibitor causes mal-absorption of calcium that leads to poor bone metabolism might causes hip fracture. Some studies via microRNA gene regulatory networks have been analyzed in the present study.
Methods

Microarray gene expression dataset has been retrieved by using NCBI gene expression Omnibus (GEO) database. Benjomini and Hochberg algorithm was used for identifying DEG’s and pre-processing of datasets. Heatmap plot and principal component analysis plot were generated by using online tool ClustVis for DEG’s. PPI network and sub network were analyzed by finding functional interactions among protein via online tool STRING v 10.5. DEG’s functional pathways analysis has been done by using DAVID (Database for Annotation, Visualization and Integration Discovery) software.
Results

A number of 3390 differentially expressed genes (DEG’s) were identified. …..were up-regulated and were down-regulated genes. DEGs related to Hypocalcemia and Bone signaling were 53, osteogenesis and bone signaling both were 86, whereas, 8 DEG’s related to hypocalcemia, Osteogenesis, and Bone signaling. The network of protein-protein interaction and sub network was having ITCH, CKAP4(Up) and FBXW11, RAB37(down) DEGs were concerned in hypocalcemia and were forming hub nodes while CHML, ATP11A, TMEM30A (Up) and YWHAE, AP1M1, FYN(down) DEG’s forming were all related to bone signaling. Functional enrichment analysis was performed notably enriched major molecular functions, biological processes and cellular components of novel DEG’s (FDR<0.05) related to hypocalcemia and osteoporosis were found.
Conclusion

Thus by concluding the genes ie; ITCH, CKAP4, FBXW11, RAB37, CHML, ATP11A, TMEM30A, YWHAE, AP1M1, FYN, CTNNB1, UBE2D1, RAP1A, EGFR, MAPK1 and AKT1, whether are unregulated or downregulatd in the diseased tissue samples, and plays a essential role in disease progression. These hub genes are occupied in different biological, molecular and cellular functions which might be related to bone signaling or osteoporosis. For the further cross validation wet lab experiments are required to validate gene roles.
Validation of the usefulness of a corrective underwear step system
Authors: Kamiura Shoji , Yoshida Yasuhiko , Kuratomo Kiri 
Published: January 2022

Abstract
The main changes in women's body shape due to aging include the descent of the breasts, tension in the abdomen, descent of the hips, increase in fat from the waist to the pelvis, and loss of waist definition. We adopted a system in which skilled body fitters correctly fitted subjects with underwear of different functions made based on the corrective underwear step system. This study was designed to use a three-dimensional (3D) body scanner to examine (1) the effects of aging and other factors on body shape changes, and (2) the status of the effect of moving and fixing fat flowing to the axillae and back to improve body shape. The results of the 8-month study have suggested that the system affected changes in the body shape, especially in the breasts. By using this method, not only the body line can be expected to improve.
The authors have requested that this preprint be removed from Research Square.
Authors: Zhou Zhengqing , Li Dian-Jie , Zhao Ziheng , Shi Shuyu , Wu Jianghua , Li Jianwei , Zhang Jingpeng , Gui Ke , Zhang Yu , Ouyang Qi , Mei Heng , Hu Yu , Li Fangting 
Published: January 2022

Abstract
The authors have requested that this preprint be removed from Research Square.
Superluminal Communication with Polarized Entangled Photons
Authors: Ritzmann Vinicius 
Published: January 2022

Abstract
In this work, we show that Quantum Mechanics predicts that two people who share entangled polarized pairs of photons can communicate faster than light. We show this communication only occurs in one direction, from person B to A. Person B can send information to A by measuring the polarization of his photons in different directions. Person A can find out in which direction B has measured his photons by measuring how much light passes through an optical circuit. We show this communication is instantaneous because it is based on the collapse of the wave function of the entangled pair, which collapse is instantaneous. We conclude that regardless of whether this method of communication works or not in practice, we have something new because if it works, it would be a contradiction to the theories of Relativity, and if it does not work, Quantum Mechanics would be predicting something that does not happen in real life.
A Novel 10-genes Ferroptosis-Related Prognostic Signature in Acute Myeloid Leukemia
Authors: Zhu Kai , Lang Zhichao , Zhan Yating , Tao Qiqi , Yu Zhijie , Jin Yan , Zhu Bihan , Gao Yuxiang , Wang Chengchi , Yu Kang , Shi Yifen , Jiang Songfu 
Published: January 2022

Abstract
Acute myeloid leukemia (AML) is one of the most common hematopoietic malignancies and exhibits a high rate of relapse and unfavorable outcomes. Ferroptosis, a relatively recently described type of cell death, has been reported to be involved in cancer development. However, the prognostic value of ferroptosis-related genes (FRGs) in AML remains unclear. In this study, we found 54 differentially expressed ferroptosis-related genes (DEFRGs) between AML and normal marrow tissues. Eighteen of these 54 DEFRGs were correlated with overall survival (OS) (P <0.05). Using the least absolute shrinkage and selection operator (LASSO) Cox regression analysis, we selected 10 DEFRGs that were associated with OS to build a prognostic signature. Data from AML patients from the International Cancer Genome Consortium (ICGC) cohort were used for validation. Notably, the prognostic survival analyses of this signature passed with a significant margin, and the risk score was identified as an independent prognostic marker using Cox regression analyses. Further studies showed that AML was significantly associated with immune cell infiltration. In addition, drug-sensitive analysis showed that 8 drugs may be beneficial for treatment of AML and we used our own data (FAHWMU cohort) as a clinical validation. In conclusion, our study establishes a novel 10-gene prognostic risk signature based on ferroptosis related genes for AML patients and additionally we provide evidence that FRGs may be novel therapeutic targets for AML.
Geography of pharmaceutical gardens and courtyards in Moscow at the end of the 16th – first half of the 18th century: Problems of localization and functioning
Authors: Худин К.С. , Шахова А.Д. 
Published: January 2022

Статья посвящена географии аптекарских садов (огородов) и дворов Москвы в конце XVI – первой половине XVIII века. Рассматриваются семь садов с дворами, существовавшие в распоряжении аптечного ведомства (Аптекарского приказа и Медицинской канцелярии). Определены границы участков и проведена их привязка к современным городским территориям, установлены хронологические рамки для каждого из садов, а также ассортимент растений, которые там культивировались. В статье использован большой комплекс картографических материалов и письменных архивных источников, часть которых впервые вводится в научный оборот.
The article is devoted to the geography of pharmaceutical gardens (vegetable gardens) and courtyards in Moscow at the end of the 16th – first half of the 18th century. It examines seven gardens with courtyards that existed at the disposal of the pharmaceutical agency (the Apothecary Prikaz and the Medical Chancellery). The article defines the boundaries of the plots, links them to modern urban areas, establishes the chronological framework for each of the gardens, and determines the assortment of plants that were cultivated there. The research is based on a large number of cartographic materials and written archival sources, some of which have been never before discussed in scholarly literature.
Geographical research and geopolitical collisions associated with the international project of connecting Chukotka with Alaska by a telegraph cable
Authors: Постников А.В. , Константинов М.В. 
Published: January 2022

Статья посвящена истории создания трансконтинентальной телеграфной линии, которая должна была соединить российские владения в Северной Америке с метрополией и обеспечить надежную связь между Евразией и Америкой. История возникновения и реализации этого проекта поставлена в контекст международных отношений в северной части Тихого океана во второй половине XIX в., ключевыми сторонами которых были Россия, стремившаяся укрепить свои позиции на Дальнем Востоке, и США, намеревавшиеся поставить под свой контроль всю Северную Америку и распространить коммерческие интересы США на российский Дальний Восток. Детально рассматриваются различные российские и иностранные проекты прокладки телеграфной линии, а также ход телеграфной экспедиции и географические исследования, проведенные в ее рамках.
The article is devoted to the history of the creation of a transcontinental telegraph line, which was supposed to connect the Russian possessions in North America with the metropolis and provide a reliable link between Eurasia and America. This project is set in the context of international relations in the North Pacific during the second half of the 19th century. The key parties were Russia, seeking to strengthen its positions in the Far East, and the United States, intending to bring the whole of North America under its control and to expand US commercial interests in the Russian Far East. Various Russian and foreign projects to lay a telegraph line are examined in detail, as well as the course of the telegraph expedition and the geographical research conducted as part of it.
PERAN PENGETAHUAN ETIKA PADA PERILAKU MANAJEMEN LABA: PERSEPSI AKADEMISI DAN PRAKTISI
Authors: Utami Tri 
Published: January 2022

ABSTRAK Ada banyak cara yang dapat dilakukan oleh manajer dan akuntan untuk mempengaruhi pelaporan keuangan dalam suatu unit organisasi, salah satu cara yang dapat dilakukan adalah dengan melakukan manajemen laba, namun Tindakan manajemen laba bisa dikaitkan dengan perilaku etika seseorang. Tujuan pertama dari penelitian ini adalah untuk menguji apakah ada perbedaan keberterimaan etika antara akademisi dan praktisi. Tujuan kedua adalah untuk mengelompokkan beberapa kejadian ekonomi ke dalam faktor manajemen laba. Populasi dalam penelitian ini adalah Praktisi dan Akademisi di bidang akuntansi. Sampel dipilih dengan teknik purposive sampling. Hasil analisis menggunakan Anova membuktikan bahwa terdapat perbedaan keberterimaan etika yang signifikan diantara tiga kelompok responden (akademisi S1, akademisi S2, dan Praktisi). Praktisi menganggap bahwa tindakan manajemen laba sebagai suatu tindakan yang cukup etis, sedangkan akademisi menganggap bahwa perilaku manajemen laba sebagai suatu tindakan yang kurang etis. Hasil analisis menggunakan Principal Component Analysis mengelompokkan beberapa kejadian ekonomi yang sering dilakukan dalam manajemen laba, yaitu melalui penundaan biaya, persediaan, aset tetap dan kebijakan penjualan. Keywords: pengetahuan etika, manajemen laba, sikap ABSTRACT There are several ways to influence financial reporting, one of them is earnings management practice. The first purpose of this study is to test ethical acceptability differences between academics and practitioners. The second purpose of this study is to determine events and transactions into earnings management factor. Population from this study is academics and practitioner in accounting. The sample is chosen using purposive sampling. Statistical test is used in this study is Anova and Principal Component Analysis. This study show that there are significant differences about ethical acceptability between academics and practitioner. Academics assume earnings management as less ethical, while practitioners assume more ethical. Some of event and transaction which used in earnings management are deferred charges, inventory manipulation, property plant and equipment, and sales discretion.Keywords: ethical knowledge, earnings management, attitude
Properties of serum albumin in electrolyzed water
Authors: Pogorelov Alexander , Ipatova Larisa , Pogorelova Maria , Kuznetsov Alexander , Suvorov Oleg 
Published: January 2022

Introduction. Electrochemical activation of water controls the physicochemical parameters of aquatic food environment without any reagents. Electrolyzed water affects the properties of macronutrient solutions. The present research studied the effect of anodic and cathodic fractions of electrochemically activated water on protein molecules and their interaction patterns.
Study objects and methods. The study featured bovine serum albumin and its properties in electrochemically activated water with nonstandard redox and acidity values. The aqueous solution of bovine serum albumin was studied by viscometry, UV spectrometry, time-of-flight secondary ion mass spectrometry, and electrophoresis.
Results and discussion. By knowing the interaction patterns of electrochemically activated water and protein molecules, food producers can control the properties of biological raw materials. Bovine serum albumin was studied in metastable fractions of electrochemically activated water obtained in the anode or cathode chamber of an electrochemical reactor. Both fractions of electrochemically activated water appeared to modify the properties of bovine serum albumin. The oxidized fraction of electrochemically activated water (anolyte) converted the protein solution into a more homogeneous molecular composition. The solution of bovine serum albumin in the reduced fraction of electrochemically activated water (catholyte) had an abnormally negative redox potential (–800 mV). The aqueous solution of bovine serum albumin in catholyte retained its initial viscosity for a long time, and its level was lower than in the control sample. This effect was consistent with other physicochemical characteristics of the solution.
Conclusion. The research revealed some patterns that make it possible to apply reagent-free viscosity regulation to protein media in the food industry.
Black mahlab (Monechma ciliatum L.) seeds: processing effects on chemical composition and nutritional value
Authors: Mariod Abdalbasit Adam , Abdalrahman Eshraga Mustafa , Shakak Mahdi Abbas 
Published: January 2022

Introduction. Monechma ciliatum L. seeds are rich in proteins, carbohydrates, oils and mineral contents. Researchers have focused on new production development but there is no available data on the impact of processing techniques on the quality of the seeds. Our study aimed to investigate the impact of boiling, roasting, and germination on the composition and nutritional value of Monechma ciliatum (black mahlab) seeds.
Study objects and methods. We analyzed 7 kg of black mahlab seeds purchased from the local market. We applied standard methods used in boiling, roasting, and germination techniques. Proximate analyses were performed using the methods of the Association of Official Analytical Chemists. Minerals were analyzed by inductively coupled plasma-mass spectrometry (ICP-MS), and fatty acids were determined by gas chromatography. Tocopherols and amino acids in processed seeds were determined by high-performance liquid chromatography.
Results and discussion. The results showed that the proximate compositions of untreated, boiled, roasted, and germinated mahlab seeds were affected by boiling, roasting, and germination techniques. Most of the nutritional values were enhanced by all the treatments. In particular, all the processing techniques increased the protein content. Boiling and roasting increased the fat content, while boiling and germination increased the fiber content. Tocopherols were higher only in the germinated samples. Amino acids were increased by all the techniques. Minerals were affected by all the techniques, except for Na, which was higher in the germinated sample.
Conclusion. Boiling, roasting, and germination enhanced significantly the chemical composition of Monechma ciliatum seeds, which make them a value ingredient to develop new food products.