bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of early granulocyte-colony-stimulating factor administration in the prevention of febrile neutropenia and impact on toxicity and efficacy of anti-CD19 CAR-T in patients with relapsed/refractory B-cell lymphoma
Authors: Liévin Raphaël , Di Blasi Roberta , Morin Florence , Galli Eugenio , Allain Vincent , De Jorna Romain , Vercellino Laetitia , Parquet Nathalie , Mebarki Miryam , Larghero Jerome , de Kerviler Eric , Madelaine Isabelle , Caillat-Zucman Sophie , Chevret Sylvie , Thieblemont Catherine 
Published: January 2022

AbstractChimeric Antigen Receptor T cells (CAR-T) are an outbreaking treatment option for relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL). Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) are the most common specific toxicities, while severe neutropenia and infections are often observed as well. From March 2020, early G-CSF prophylaxis at day (D) two post-infusion was systematically proposed. We then compared patients treated before that date who did not receive G-CSF or who received late (after D5) G-CSF as control group. Patients administered with early G-CSF had similar duration of grade 4 neutropenia but significantly decreased incidence of febrile neutropenia (58% versus 81%, p = 0.018). Similar rate of toxicities was observed, including overall and grade 3-4 CRS (p = 0.93 and p = 0.28, respectively), and overall and grade 3-4 ICANS (p = 0.62 and p = 0.88, respectively). We observed no difference in the quality of CAR T-cells expansion (p = 0.79, %Cmax), nor in response rate (best ORR, 57.6% vs 61.8%, p = 0.93), nor survival even in a group of patients adjusted by a propensity score. In conclusion, early G-CSF administration was safe and effective in reducing febrile neutropenia without impact on toxicities nor on anti-lymphoma activity of CAR-T.
Molecular insights into the interaction of HPV-16 E6 variants against MAGI-1 PDZ1 domain
Authors: Araujo-Arcos Lilian Esmeralda , Montaño Sarita , Bello-Rios Ciresthel , Garibay-Cerdenares Olga Lilia , Leyva-Vázquez Marco Antonio , Illades-Aguiar Berenice 
Published: February 2022

AbstractOncogenic protein E6 from Human Papilloma Virus 16 (HPV-16) mediates the degradation of Membrane-associated guanylate kinase with inverted domain structure-1 (MAGI-1), throughout the interaction of its protein binding motif (PBM) with the Discs-large homologous regions 1 (PDZ1) domain of MAG1-1. Generic variation in the E6 gene that translates to changes in the protein’s amino acidic sequence modifies the interaction of E6 with the cellular protein MAGI-1. MAGI-1 is a scaffolding protein found at tight junctions of epithelial cells, where it interacts with a variety of proteins regulating signaling pathways. MAGI-1 is a multidomain protein containing two WW (rsp-domain-9), one guanylate kinase-like, and six PDZ domains. PDZ domains played an important role in the function of MAGI-1 and served as targets for several viral proteins including the HPV-16 E6. The aim of this work was to evaluate, with an in silico approach, employing molecular dynamics simulation and protein–protein docking, the interaction of the intragenic variants E-G350 (L83V), E-C188/G350 (E29Q/L83V), E-A176/G350 (D25N/L83V), E6-AAa (Q14H/H78Y/83V) y E6-AAc (Q14H/I27RH78Y/L83V) and E6-reference of HPV-16 with MAGI-1. We found that variants E-G350, E-C188/G350, E-A176/G350, AAa and AAc increase their affinity to our two models of MAGI-1 compared to E6-reference.
Comorbidities in Children with COVID-19 and MIS-C/PIMS-TS and
Risk Factors for Hospitalization, Severe Disease, Intensive Care and
Death
Authors: Ankermann Tobias , Brinkmann Folke 
Published: February 2022

AbstractThis narrative review sums up data from the SARS-CoV-2-pandemia on preexisting
disease/underlying conditions/comorbidities and risk factors in
children for severe COVID-19 and MIS-C/PIMS-TS as well as
hospitalization and mortality. Young infants and adolescents are at highest risk
of hospital and PICU admission. Two or more comorbidities rather than single
entities pose a risk for more severe courses of SARS-CoV-2 infection in
children. Asthma and malignancy do not increase complication rates.
MIS-C/PIMS-TS is not associated with any specific underlying
disease.
Can Prehospital Data Improve Early Identification of Sepsis in Emergency Department? An Integrative Review of Machine Learning Approaches
Authors: Desai Manushi D. , Tootooni Mohammad S. , Bobay Kathleen L. 
Published: February 2022

Abstract
Background Sepsis is associated with high mortality, especially during the novel coronavirus disease 2019 (COVID-19) pandemic. Along with high monetary health care costs for sepsis treatment, there is a lasting impact on lives of sepsis survivors and their caregivers. Early identification is necessary to reduce the negative impact of sepsis and to improve patient outcomes. Prehospital data are among the earliest information collected by health care systems. Using these untapped sources of data in machine learning (ML)-based approaches can identify patients with sepsis earlier in emergency department (ED).
Objectives This integrative literature review aims to discuss the importance of utilizing prehospital data elements in ED, summarize their current use in developing ML-based prediction models, and specifically identify those data elements that can potentially contribute to early identification of sepsis in ED when used in ML-based approaches.
Method Literature search strategy includes following two separate searches: (1) use of prehospital data in ML models in ED; and (2) ML models that are developed specifically to predict/detect sepsis in ED. In total, 24 articles are used in this review.
Results A summary of prehospital data used to identify time-sensitive conditions earlier in ED is provided. Literature related to use of ML models for early identification of sepsis in ED is limited and no studies were found related to ML models using prehospital data in prediction/early identification of sepsis in ED. Among those using ED data, ML models outperform traditional statistical models. In addition, the use of the free-text elements and natural language processing (NLP) methods could result in better prediction of sepsis in ED.
Conclusion This study reviews the use of prehospital data in early decision-making in ED and suggests that researchers utilize such data elements for prediction/early identification of sepsis in ML-based approaches.
Evolution of nuclear charge radii in copper and indium isotopes *
Authors: An Rong , Jiang Xiang , Cao Li-Gang , Zhang Feng-Shou 
Published: January 2022

Abstract
Systematic trends in nuclear charge radii are of great interest due to universal shell effects and odd-even staggering (OES). The modified root mean square (rms) charge radius formula, which phenomenologically accounts for the formation of neutron-proton (np) correlations, is here applied for the first time to the study of odd-Z copper and indium isotopes. Theoretical results obtained by the relativistic mean field (RMF) model with NL3, PK1 and NL3* parameter sets are compared with experimental data. Our results show that both OES and the abrupt changes across

and 82 shell closures are clearly reproduced in nuclear charge radii. The inverted parabolic-like behaviors of rms charge radii can also be described remarkably well between two neutron magic numbers, namely

to 50 for copper isotopes and

to 82 for indium isotopes. This implies that the np-correlations play an indispensable role in quantitatively determining the fine structures of nuclear charge radii along odd-Z isotopic chains. Also, our conclusions have almost no dependence on the effective forces.
Effects of Self-gravity on Mass-loss of the Post-impact Super-Earths
Authors: Huang Jiang , Zhong Wei , Yu Cong 
Published: January 2022

Abstract
Kepler’s observations show most of the exoplanets are super-Earths. The formation of a super-Earth is generally related to the atmospheric mass loss that is crucial in the planetary structure and evolution. The shock driven by the giant impact will heat the planet, resulting in the atmosphere escape. We focus on whether self-gravity changes the efficiency of mass loss. Without self-gravity, if the impactor mass is comparable to the envelope mass, there is a significant mass-loss. The radiative-convective boundary will shift inward by self-gravity. As the temperature and envelope mass increase, the situation becomes more prominent, resulting in a heavier envelope. Therefore, the impactor mass will increase to motivate the significant mass loss, as the self-gravity is included. With the increase of envelope mass, the self-gravity is particularly important.
Explaining the Multiwavelength Emission of Hard-TeV BL Lac Objects Using a Truncated Conical Jet Model
Authors: Lei Maichang , Zheng Yuan , Zhang Jianfu , Wang Jiancheng 
Published: January 2022

Abstract
Hard-TeV BL Lac objects are newly identified populations of active galactic nuclei with the emitted γ-ray photons well above TeV energies. In this paper, we explain the multiwavelength emission of six Hard-TeV BL Lac objects by using a truncated conical emission region of the jet, where the electron distribution is obtained by numerically solving the evolution equation along the jet self-consistently. For comparison, we also apply the model to Mrk 421 and Mrk 501, which are the potential candidates for the hard TeV emissions. We demonstrate that the model can satisfactorily reproduce the spectral energy distributions of eight sources, particularly of six Hard-TeV sources, where no extreme minimum Lorentz factor of the electron population is required. In contrast with Mrk 421 and Mrk 501, six Hard-TeV sources have rather low magnetization in emitting regions and high cutoff energies of the electron distributions.
Solar Supergranular Fractal Dimension Dependence on the Solar Cycle Phase
Authors: Rajani G. , Sowmya G. M. , Paniveni U. , Srikanth R. 
Published: January 2022

Abstract
We study the complexity of the supergranular network through fractal dimension by using the Ca ii K digitized data archive obtained from the Kodaikanal Solar Observatory. The data consist of 326 visually selected supergranular cells spread across the 23rd solar cycle. Only cells that were well-defined were chosen for the analysis and we discuss the potential selection effect thereof, mainly that it favors cells of a smaller size (<20 Mm). Within this sample, we analyzed the fractal dimension of supergranules across the solar cycle and find that it is anticorrelated with the activity level.
Oocyte mitochondria—key regulators of oocyte function and potential therapeutic targets for improving fertility
Authors: Adhikari Deepak , Lee In-won , Yuen Wai Shan , Carroll John 
Published: January 2022

AbstractThe development of oocytes and early embryos is dependent on mitochondrial ATP production. This reliance on mitochondrial activity, together with the exclusively maternal inheritance of mitochondria in development, places mitochondria as central regulators of both fertility and transgenerational inheritance mechanisms. Mitochondrial mass and mtDNA content massively increase during oocyte growth. They are highly dynamic organelles and oocyte maturation is accompanied by mitochondrial trafficking around subcellular compartments. Due to their key roles in generation of ATP and reactive oxygen species (ROS), oocyte mitochondrial defects have largely been linked with energy deficiency and oxidative stress. Pharmacological treatments and mitochondrial supplementation have been proposed to improve oocyte quality and fertility by enhancing ATP generation and reducing ROS levels. More recently, the role of mitochondria-derived metabolites in controlling epigenetic modifiers has provided a mechanistic basis for mitochondria–nuclear crosstalk, allowing adaptation of gene expression to specific metabolic states. Here, we discuss the multi-faceted mechanisms by which mitochondrial function influence oocyte quality, as well as longer-term developmental events within and across generations.
Endometrial and luteal responses to a prostaglandin F2alpha pulse: a comparison between heifers and mares
Authors: Domingues Rafael R , Ginther O J , Gomez-Leon Victor , Castro Thadeu , Wiltbank Milo C 
Published: January 2022

Abstract
In heifers and mares, multiple pulses of prostaglandin F2alpha (PGF) are generally associated with complete luteal regression. Although PGF pulses occur before and during luteolysis, little is known about the role of minor PGF pulses during preluteolysis on subsequent luteal and endometrial PGF production that may initiate luteolysis. Heifers (n = 7/group) and mares (n = 6/group) were treated with a single minor dose of PGF (3.0 and 0.5 mg, respectively) during mid-luteal phase (12 and 10 days postovulation respectively). After treatment, a transient decrease in progesterone (P4) concentrations occurred in heifers between Hours 0 and 2 but at Hour 4 P4 was not different from pretreatment. In mares, P4 was unaltered between Hours 0 and 4. Concentrations of P4 decreased in both species by Hour 24 and complete luteolysis occurred in mares by Hour 48. Luteal and endometrial gene expression were evaluated 4 h posttreatment. In heifers, luteal mRNA abundance of PGF receptor and PGF dehydrogenase was decreased, while PTGS2, PGF transporter, and oxytocin receptor were increased. In the heifer endometrium, receptors for oxytocin, P4, and estradiol were upregulated. In mares, luteal expression of PGF receptor was decreased, while PGF transporter and oxytocin receptor were increased. The decrease in P4 between Hours 4 and 24 and changes in gene expression were consistent with upregulation of endogenous synthesis of PGF. The hypotheses were supported that a single minor PGF treatment upregulates endogenous machinery for PGF synthesis in heifers and mares stimulating endogenous PGF synthesis through distinct regulatory mechanisms in heifers and mares.
Formation and function of dauer ascarosides in the nematodes Caenorhabditis briggsae and Caenorhabditis elegans
Authors: Cohen Sarah M , Wrobel Chester J J , Prakash Sharan J , Schroeder Frank C , Sternberg Paul W 
Published: January 2022

Abstract
The biosynthetic pathways and functions of ascaroside signaling molecules in the nematode Caenorhabditis elegans have been studied to better understand complex, integrative developmental decision-making. Although it is known that ascarosides play multiple roles in the development and behavior of nematode species other than C. elegans, these parallel pheromone systems have not been well-studied. Here, we show that ascarosides in the nematode Caenorhabditis briggsae are biosynthesized in the same manner as C. elegans and act to induce the alternative developmental pathway that generates the stress-resistant dauer lifestage. We show that ascr#2 is the primary component of crude dauer pheromone in C. briggsae; in contrast, C. elegans dauer pheromone relies on a combination of ascr#2, ascr#3, and several other components. We further demonstrate that Cbr-daf-22, like its C. elegans ortholog Cel-daf-22, is necessary to produce short-chain ascarosides. Moreover, Cbr-daf-22 and Cel-daf-22 mutants produce an ascaroside-independent metabolite that acts antagonistically to crude dauer pheromone and inhibits dauer formation.
Objectively Measured Total Sedentary Time and Pattern of Sedentary Accumulation in Older Adults: Associations With Incident Cardiovascular Disease and All-Cause Mortality
Authors: Yerramalla Manasa Shanta , van Hees Vincent T , Chen Mathilde , Fayosse Aurore , Chastin Sebastien F M , Sabia Séverine 
Published: January 2022

Abstract

Background
We examined associations of total duration and pattern of accumulation of objectively measured sedentary behavior (SB) with incident cardiovascular disease (CVD) and all-cause mortality among older adults.

Methods
Total sedentary time and 8 sedentary accumulation pattern metrics were extracted from accelerometer data of 3 991 Whitehall II study participants aged 60–83 years in 2012–2013. Incident CVD and all-cause mortality were ascertained up to March 2019.

Results
Two hundred and ninety-nine CVD cases and 260 deaths were recorded over a mean (standard deviation [SD]) follow-up of 6.2 (1.3) and 6.4 (0.8) years, respectively. Adjusting for sociodemographic and behavioral factors, 1-SD (100.2 minutes) increase in total sedentary time was associated with 20% higher CVD risk (hazard ratio [95% confidence interval]: 1.20 [1.05–1.37]). More fragmented SB was associated with reduced CVD risk (eg, 0.86 [0.76–0.97] for 1-SD [6.2] increase in breaks per sedentary hour). Associations were not evident once health-related factors and moderate-to-vigorous physical activity (MVPA) were considered. For all-cause mortality, associations with more fragmented SB (eg, 0.73 [0.59–0.91] for breaks per sedentary hour) were found only among the youngest older group (&lt;74 years; p for interaction with age &lt; .01) independently from all covariates.

Conclusions
In this study, no associations of total sedentary time and sedentary accumulation patterns with incident CVD and all-cause mortality were found in the total sample once MVPA was considered. Our findings of reduced mortality risk with less total and more fragmented SB independent from MVPA among individuals &lt;74 years need to be replicated to support the recent recommendations to reduce and fragment SB.
Algorithm Design for a Cytokine Release Assay of Antigen-Specific In Vitro Stimuli of Circulating Leukocytes to Classify Leprosy Patients and Household Contacts
Authors: Marçal Pedro Henrique Ferreira , de Souza Márcio Luís Moreira , Gama Rafael Silva , de Oliveira Lorena Bruna Pereira , Gomes Matheus de Souza , do Amaral Laurence Rodrigues , Pinheiro Roberta Olmo , Sarno Euzenir Nunes , Moraes Milton Ozório , Fairley Jessica K , Martins-Filho Olindo Assis , de Oliveira Fraga Lucia Alves 
Published: January 2022

AbstractBackgroundImmunological biomarkers have often been used as a complementary approach to support clinical diagnosis in several infectious diseases. The lack of commercially available laboratory tests for conclusive early diagnosis of leprosy has motivated the search for novel methods for accurate diagnosis. In the present study, we describe an integrated analysis of a cytokine release assay using a machine learning approach to create a decision tree algorithm. This algorithm was used to classify leprosy clinical forms and monitor household contacts.MethodsA model of Mycobacterium leprae antigen-specific in vitro assay with subsequent cytokine measurements by enzyme-linked immunosorbent assay was employed to measure the levels of tumor necrosis factor (TNF), interferon-γ, interleukin 4, and interleukin 10 (IL-10) in culture supernatants of peripheral blood mononuclear cells from patients with leprosy, healthy controls, and household contacts. Receiver operating characteristic curve analysis was carried out to define each cytokine’s global accuracy and performance indices to identify clinical subgroups.ResultsData demonstrated that TNF (control culture [CC]: AUC = 0.72; antigen-stimulated culture [Ml]: AUC = 0.80) and IL-10 (CC: AUC = 0.77; Ml: AUC = 0.71) were the most accurate biomarkers to classify subgroups of household contacts and patients with leprosy, respectively. Decision tree classifier algorithms for TNF analysis categorized subgroups of household contacts according to the operational classification with moderate accuracy (CC: 79% [48/61]; Ml: 84% [51/61]). Additionally, IL-10 analysis categorized leprosy patients’ subgroups with moderate accuracy (CC: 73% [22/30] and Ml: 70% [21/30]).ConclusionsTogether, our findings demonstrated that a cytokine release assay is a promising method to complement clinical diagnosis, ultimately contributing to effective control of the disease.
Circadian rhythm disruption results in visual dysfunction
Authors: Mathew Deepa , Luo Qianyi , Bhatwadekar Ashay D. 
Published: January 2022

AbstractArtificial light has been increasingly in use for the past 70 years. The aberrant light exposure and round‐the‐clock nature of work lead to the disruption of biological clock. Circadian rhythm disruption (CRD) contributes to multiple metabolic and neurodegenerative diseases. However, its effect on vision is not understood. Moreover, the mammalian retina possesses an autonomous clock that could be reset with light exposure. We evaluated the impact of CRD on retinal morphology, physiology, and vision after housing mice in a disruption inducing shorter light/dark cycle (L10:D10). Interestingly, the mice under L10:D10 exhibited three different entrainment behaviors; “entrained,” “free‐running,” and “zigzagging.” These behavior groups under CRD exhibited reduced visual acuity, retinal thinning, and a decrease in the number of photoreceptors. Intriguingly, the electroretinogram response was decreased only in the mice exhibiting “entrained” behavior. The retinal proteome showed distinct changes with each entrainment behavior, and there was a dysfunctional oxidative stress‐antioxidant mechanism. These results demonstrate that CRD alters entrainment behavior and leads to visual dysfunction in mice. Our studies uniquely show the effect of entrainment behavior on retinal physiology. Our data have broader implications in understanding and mitigating the impact of CRD on vision and its potential role in the etiology of retinal diseases.
Efficacy of transcutaneous tibial nerve stimulation in the treatment of bladder pain syndrome
Authors: Alkis Okan , Aras Bekir , Sevim Mehmet , Kartal İbrahim Güven , Sönmez Oğuzhan Yusuf , İvelik Halil İbrahim 
Published: January 2022

Abstract

Background:
This study aimed to demonstrate the effectiveness of transcutaneos tibial nerve stimulation (TTNS) in the treatment of bladder pain syndrome (BPS).

Materials and methods:
The data of 16 female patients, diagnosed with BPS in our clinic between 2019 and 2021 and had TTNS twice a week for 12 weeks, were retrospectively analyzed.

Results:
The mean age of the patients was 46.00 ± 13.11 years, and the mean body mass index was 26.43 ± 3.07 kg/m2. After the treatment, the median day time frequency of the patients decreased from 13.37 (3.69) to 10.25 (4.56) (p
< 0.001). Nocturia also decreased after treatment from 4.37 (1.81) to 3.00 (1.94) (p
= 0.001). The median voiding volume increased by 26.5 mL (p
= 0.001). The median of the patients’ visual analog scale scores decreased after treatment (median of visual analog scale score changed from interquartile range 8 [1] to 7 [4]) (p
= 0.001). In addition, the median interquartile range interstitial cystitis symptom index scores decreased from 17 (4) to 15 (10) (p = 0.002).

Conclusions:
In this study it was demonstrated that TTNS is an alternative method that can be successfully applied before invasive methods in the treatment of BPS.
Construction and application of time-effect assessment database for experiments on war-traumatized animals
Authors: Wang Junkang , Wang Jing , Zhang Hongliang , Guo Chengyu , Wang Yanbiao , Lu Bing , Feng Cong , Pan Fei , Li Tanshi 
Published: January 2022

Abstract

Background
High-quality real war trauma data are important, but they are still lacking. Using the database to realize the networked, systematic, standardized, and dynamic management of war injury animal experimental data can provide a real and reliable supplement for the research of war injury treatment.

Methods
Through demand analysis, module design, architecture design, compilation and debugging, and other processes, JAVA language development tools were used to develop a time-effect assessment database for experiments on war-traumatized animals, where the browser/server architecture (B/S architecture) is used as the technical architecture and SQL Server as the database management system.

Results
A time-effect assessment database for experiments on war-traumatized animals that features reasonable structural design, rich data resources, and convenient use has been established, in which case efficient collection, storage, display, retrieval, and management of animal experimental data have been achieved. At present, the database is running well and has good data quality.