bluuebunny/crossref_metadata_2025_split huggingface dataset:
University population-based prospective cohort study of SARS-CoV-2 infection and immunity (SARSSURV-ULiège): a study protocol
Authors: Donneau Anne-Françoise , Guillaume Michèle , Bours Vincent , Dandoy Margaux , Darcis Gilles , Desmecht Daniel , Diep Anh Nguyet , Fievez Laurence , Garigliany Mutien-Marie , Gillain Nicolas , Husson Eddy , Michel Fabienne , Moutschen Michel , Paridans Marine , Benoît Pétre , Sabatel Catherine , Saegerman Claude , Tytgat Amandine , Gillet Laurent , Bureau Fabrice 
Published: January 2022

IntroductionFor a safe and sustainable return to normal functioning of academic activities in higher education, objective-driven testing strategies that are flexible and rapidly adaptable are essential to effectively monitor and respond to new developments of the COVID-19 pandemic. To date, prospective longitudinal research on SARS-CoV-2 antibody testing in saliva and seroprevalence in higher education contexts is substantially lacking, limiting our understanding of COVID-19 prevalence, incidence and nature of the immune response to SARS-CoV-2 at various stages of the infection and vaccination. To address this lack of evidence, a prospective population-based cohort study (SARSSURV-ULiège) has recently been started.Methods and analysisStudents (n=1396) and staff members (n=1143) of the University of Liège are followed up over more than 1 year. All participants are required to complete anamnestic, clinical and vaccine hesitancy questionnaires for medical histories and undertaken treatments. Previous proven or suspected SARS-CoV-2 infection is also registered. In phase 1, weekly saliva samples to perform RT-qPCR to detect SARS-CoV-2 and monthly COVID-19 serological rapid test results are collected. Once being positive to either saliva RT-qPCR assay for SARS-CoV-2 presence or to serological test, the participant is invited to enter phase 2. If participants get vaccinated during the study period, they are invited to phase 2. In this second phase, besides weekly saliva self-test, depending on the participants’ profiles, both gargle and blood samples are collected to obtain various biological data to measure the presence of neutralising antibodies against SARS-CoV-2, determine the magnitude and the duration of antibody responses over time.Ethics and disseminationThe study has received the approval from the University Hospital of Liège Ethics Committee (reference number 2021/96, dated 26 March 2021). Potential protocol amendments will be presented to the Research Ethics Committee. The findings of the present study will be presented at scientific conferences and the results published in peer-review publications. Weekly reports will be submitted to the risk assessment group and the risk management group against COVID-19 of the university to enable a timely public health action if necessary.
Impact of the COVID-19 pandemic on vaccine coverage for early childhood vaccines in Alberta, Canada: a population-based retrospective cohort study
Authors: MacDonald Shannon E , Paudel Yuba Raj , Kiely Marilou , Rafferty Ellen , Sadarangani Manish , Robinson Joan L , Driedger S Michelle , Svenson Lawrence W 
Published: January 2022

ObjectiveTo assess the impact of the COVID-19 pandemic on early childhood vaccination coverage in Alberta, Canada.SettingAlberta, a western Canadian province, which has a population of 4.4 million and approximately 50 000 births annually.DesignIn this retrospective cohort study, population-based administrative health data were analysed to determine the vaccination coverage for measles-containing, pertussis-containing and rotavirus vaccines.Primary outcome measureWe measured monthly and cumulative vaccine coverage. We assessed the absolute difference in monthly and cumulative coverage for each vaccine dose by comparing children due for vaccination in each month of 2019 and 2020, with follow-up to determine if missed doses were caught up later.ParticipantsWe included 114 178 children in the 2019 analysis cohort and 106 530 children in the 2020 analysis cohort.ResultsMonthly vaccination coverage in 2020 was higher than 2019 until March, when coverage significantly declined. Comparing April 2020 to 2019, coverage was 9.9% (95% CI 7.9% to 12.0%) lower for measles vaccine; 4.9% (95% CI 3.3% to 6.5%), 7.1% (95% CI 5.2% to 9.1%), 5.2% (95% CI 3.1% to 7.4%) and 8.8% (95% CI 6.6% to 10.9%) lower for first, second, third and fourth doses of pertussis-containing vaccine, respectively; and 4.0% (95% CI 2.3% to 5.7%), 7.1% (95% CI 5.1% to 9.2%) and 4.6% (95% CI 2.4% to 6.7%) lower for first, second and third doses of rotavirus vaccine, respectively. Monthly coverage improved during May to July 2020; however, some doses experienced a second decline during September to October 2020. The cumulative coverage analysis showed that the measles-containing vaccine had the largest difference in coverage at the end of follow-up.ConclusionsChildren who were due for vaccination early in the pandemic and in Fall 2020, especially those due for measles vaccination, may require additional catch-up.
The role of risk perception and affective response in the COVID-19 preventive behaviours of young adults: a mixed methods study of university students in the Netherlands
Authors: Kollmann Jelena , Kocken Paul L , Syurina Elena V , Hilverda Femke 
Published: January 2022

ObjectivesDue to an increased infection rate among young adults, they need to adhere to the preventive guidelines to stop the spread of COVID-19 and protect vulnerable others. The purpose of this mixed methods study was to explore the role of risk perception and affective response in the preventive behaviours of young adults during the COVID-19 outbreak.SettingThis study followed a convergent mixed methods design, in which a quantitative online survey (n=1081) and 10 qualitative in-depth semistructured video interviews were conducted separately in the Netherlands during April–August 2020.Participants1081 participants filled in the online survey, and 10 participants participated in the interviews. Eligibility criteria included being a university student.Primary and secondary outcome measuresData on risk perception, affective response, that is, worry, and adherence to preventive guidelines were combined and analysed during this study. There were no secondary outcome measures.ResultsThe results showed that young adults perceived their risk as low. Their affective response for their own well-being was also low; however, their affective response was high with regards to vulnerable others in their surroundings. Due to their high impersonal risk perception (ie, perceived risk to others) and high affective response, young adults adhered to most preventive guidelines relatively frequently. However, young adults sometimes neglected social distancing due to the negative effects on mental health and the uncertainty of the duration of the situation.ConclusionsIn conclusion, high impersonal risk perception and high affective response regarding others are key motivators in young adults’ preventive behaviour. To maximise adherence to the preventive guidelines, risk communication should put emphasis on the benefits to vulnerable others’ health when young adults adhere to the preventive guidelines.
What is the general Chinese public’s awareness of and attitudes towardsHelicobacter pyloriscreening and associated health behaviours? A cross-sectional study
Authors: Wang Ying-xin , Zou Jin-yu , Hu Li-feng , Liu Qi , Huang Ruo-lin , Tang Tian , Yue Qian-qian , Sun Ying-xue , Xiao Qiao , Zeng Xi , Zeng Ying 
Published: January 2022

ObjectiveTo evaluate the general population’s awareness of and attitudes towardHelicobacter pylori(HP) screening and health behaviours.DesignCross-sectional study.SettingHengyang, Hunan Province, China.ParticipantsUsing stratified cluster random sampling, a pretested structured questionnaire was used to interview members of the general population aged ≥18 years.Primary and secondary outcome measuresKnowledge of and attitudes toward HP screening and associated health behaviours, sociodemographic factors associated with HP knowledge, and screening behaviours.ResultsThis study featured 1042 participants. The average knowledge score was 11 (QL=4, QU=20, range 0–29). Approximately 68.9% of the participants said they had heard of HP, but 67.5% had never had an HP test. The most common reasons for not undergoing screening were ‘no symptoms’ (55.7%) and ‘lack of knowledge regarding the benefits of the test’ (21.1%). Independent factors related to knowledge included age, education level, occupation, HP infection, frequency of drinking unboiled water (p<0.05). Factors independently associated with screening behaviour included occupation, average monthly income, presence/absence of indigestion, stomach discomfort or pain, and/or stomach disease and knowledge score (p<0.05). Overall, 941 (90.3%) participants never used anti-HP toothpaste, and 442 (40.5%) never used serving spoons or chopsticks. The risk factors for HP infection included eating out and eating in groups (p<0.05).ConclusionIn China, the general population has poor knowledge of HP, but most people have a positive attitude towards HP screening. Being asymptomatic and lacking knowledge about testing were the main reasons for reluctance to be screened. These results highlight the urgent need for educational activities to raise awareness, enhance screening rates for HP, and encourage people to adopt a healthy lifestyle.
Physical and affective components of dyspnoea are improved by pulmonary rehabilitation in COPD
Authors: Grosbois Jean-Marie , Gephine Sarah , Kyheng Maeva , Henguelle Julie , Le Rouzic Olivier , Saey Didier , Maltais François , Chenivesse Cecile 
Published: January 2022

BackgroundDyspnoea is a multidimensional experience of breathing discomfort, but its affective dimension is unfrequently assessed in people with chronic obstructive pulmonary disease (COPD). We evaluated the effectiveness of a home-based pulmonary rehabilitation (PR) programme on the physical and affective components of dyspnoea assessed by the Dyspnoea-12 (D-12) questionnaire. We also determined the baseline characteristics that contributed to the change in D-12 scores.MethodsIn this retrospective study, 225 people with COPD (age, 65±11 years; forced expiratory volume in 1 s (FEV1), 35±15% of predicted value) were enrolled into a person-centric home-based PR, consisting of a weekly supervised 90 min home session during 8 weeks. D-12 questionnaire, health status, anxiety and depressive symptoms, exercise tolerance and general fatigue were assessed at baseline (M0), at the end of PR programme (M2), and 8 (M8) and 14 months (M14) after M0. Multivariable analysis of covariance (ANCOVA) models were performed to identify the baseline characteristics that contributed to the change in D-12 scores.ResultsBoth physical and affective components of dyspnoea and all the other outcome measures were improved at M2, M8 and M14 compared with baseline (p<0.05). Baseline body mass index was the only significant independent predictor of the changes in physical dyspnoea score, while the change in the affective dimension of dyspnoea after PR was associated with FEV1, anxiety symptoms and exercise tolerance (6 min stepper test). However, since these variables had only a small impact on the changes in D-12 questionnaire scores, results from the ANCOVA analysis should be taken cautiously.ConclusionBoth physical and affective components of dyspnoea were improved, at short term and long term, by 8 weeks of individualised home-based PR. The present results support the importance of assessing dyspnoea as a multidimensional experience during PR, warranting replication by robustly designed randomised and controlled studies.
The Holy grail of healthcare analytics: what it takes to get there?
Authors: R Gowda Naveen , Satpathy Sidhartha , Singh Angel Rajan , Behera S D 
Published: January 2022

BackgroundIndian healthcare is rapidly growing and needs efficiency more than ever, which can be achieved by leveraging healthcare analytics. National Digital Health Mission has set the stage for digital health and getting the right direction from the very beginning is important. The current study was, therefore, undertaken to find what it takes for an apex tertiary care teaching hospital to leverage healthcare analytics.AimTo study the existing Hospital Information System (HIS) at AIIMS, New Delhi and assess the preparedness to leverage healthcare analytics.MethodologyA three-pronged approach was used. First, concurrent review and detailed mapping of all running applications was done based on nine parameters by a multidisciplinary team of experts. Second, capability of the current HIS to measure specific management related KPIs was evaluated. Third, user perspective was obtained from 750 participants from all cadres of healthcare workers, using a validated questionnaire based on Delone and McLean model.ResultsInteroperability issues between applications running within the same institute, impaired informational continuity with limited device interface and automation were found on concurrent review. HIS was capturing data to measure only 9 out of 33 management KPIs. User perspective on information quality was very poor which was found to be due to poor system quality of HIS, though some functions were reportedly well supported by the HIS.ConclusionIt is important for hospitals to first evaluate and strengthen their data generation systems/HIS. The three-pronged approach used in this study provides a template for other hospitals.
From molecular data to natural history: a new species of Apatelodes (Lepidoptera: Bombycoidea: Apatelodidae) from southern Brazil
Authors: Orlandin Elton , Piovesan Mônica , Carneiro Eduardo 
Published: January 2022

Apatelodidae is a family of Neotropical bombycoids that is still poorly studied in several aspects. Besides being relatively large moths and abundant in light traps, only sources of information on the natural history of the family have been published, and basically none of this information has been used in the group’s systematics. Aiming to contribute to a better understanding of Apatelodidae life-history studies, we describe a new species of Apatelodidae (Lepidoptera: Bombycoidea) from the Atlantic Forest, southern Brazil, including information from all life stages of the species. We also use DNA barcodes to support species delimitation. Apatelodes je sp. nov. can be differentiated from other species of Apatelodes by the colour of the wings, the morphology of the genitalia, and molecular evidence. Its relationship to other Apatelodes species is discussed taking into account its systematic position, morphology, and natural history.
From the Local Economy to the Global Market. Municipal-Level Spatial Economic Modelling of International Trade for Brazil
Authors: Díaz-Dapena Alberto , Grecco Zanon Moura Ticiana , Rubiera-Morollón Fernando 
Published: January 2022

International trade is one of the key spheres of economic policy. It is crucial for a country to understand the dynamics of its export markets to create a coherent strategy to improve its position in global markets. Research in this field is particularly interesting for both economists and policy makers. However, due to a lack of data, most of the well-established literature is focused on the national level. Therefore, there is little evidence on the influence of local characteristics on export markets. This research aims to evaluate the influence of regional factors on the competitiveness of firms in international markets, focussing on the importance of agglomeration economies and location, among other local factors. To identify this influence, this paper studies the case of Brazil. This country offers rich disaggregated information that allows this type of research and displays enormous differences across rural and urban areas. Given these differences, the assumption of homogeneous effects is too restrictive. Therefore, to study the patterns across different territories around the country, Geographically Weighted Generalized Linear Model (GWGLM) method is applied. The results indicate an interaction between location and the influence of several local characteristics such as human capital, the degree of development and the local economic structure. This relationship creates virtuous circles in a few locations where urban agglomerations create a suitable environment for firms, while opposite patterns appear in other locations. JEL codes: F14, R11 and R12
Proportional integral feedback control of ultrafiltration rate in hemodialysis
Authors: Casper Sabrina , Fuertinger Doris H , Tapia Silva Leticia M , Rivera Fuentes Lemuel , Thijssen Stephan , Kotanko Peter 
Published: January 2022

Background: Most hemodialysis patients without residual kidney function accumulate fluid between dialysis session that needs to be removed by ultrafiltration. Ultrafiltration usually results in a decline in relative blood volume (RBV). Recent epidemiological research has identified RBV ranges that were associated with significantly better survival. The objective of this work was to develop an ultrafiltration controller to steer a patient’s RBV trajectory into these favorable RBV ranges. Methods: We designed a proportional-integral feedback ultrafiltration controller that utilizes signals from a device that reports RBV. The control goal is to attain the RBV trajectory associated with improved patient survival. Additional constraints such as upper and lower bounds of ultrafiltration volume and rate were realized. The controller was evaluated in in silico and ex vivo bench experiments, and in a clinical proof-of-concept study in two maintenance dialysis patients. Results: In all tests, the ultrafiltration controller performed as expected. In the in silico and ex vivo bench experiments, the controller showed robust reaction toward deliberate disruptive interventions (e.g. signal noise; extreme plasma refill rates). No adverse events were observed in the clinical study. Conclusions: The ultrafiltration controller can steer RBV trajectories toward desired RBV ranges while obeying to a set of constraints. Prospective studies in hemodialysis patients with diverse clinical characteristics are warranted to further explore the controllers impact on intradialytic hemodynamic stability, quality of life, and long-term outcomes.
An Anatomic Study of the Lateral Dorsal Cutaneous Nerve Using 3-Tesla MRI: A Comparison to Cadaveric Data With Surgical Applications
Authors: Ghetti Claudio B. , Mitchell Brendon C. , Shah Vrajesh J. , Onodera Keenan , Berger Garrett K. , Huang Brady , Foran Ian M. , Kent William T. 
Published: January 2022

Background: The lateral dorsal cutaneous nerve (LDCN) and the anastomotic branch of the sural nerve (AB) are cutaneous sensory nerves at risk of iatrogenic injury during lateral foot surgery. This study is the first to use a large cohort of high-resolution magnetic resonance images (MRIs) of the ankle to better describe the course of these nerves in vivo in order to aid surgeons intraoperatively. Our study intends to build on the “high and inside” approach to the proximal 5MT by accounting for variations in course of the LDCN and AB. Methods: One hundred twenty-five 3-tesla (T) MRI studies of the ankle were analyzed. Three reviewers measured the distance from the LDCN and AB to landmarks including the most proximal aspect of the fifth metatarsal tuberosity (5MT) and the peroneus brevis tendon (PBT). Results: Mean vertical distance from the LDCN to the 5MT was 0.8 ± 0.2 cm. Presence of an AB was visualized in 59 of 125 studies (47.2%) and was found 2.2 ± 0.5 cm dorsal to the 5MT. The AB was found to become superior to PBT at a horizontal distance 1.9 ± 0.5 cm proximal to the 5MT. The LDCN was found superior to the PBT at its insertion onto the 5MT in approximately 10% (n = 12) of our studies. During these instances, the LDCN was located an average of 0.3 cm dorsal to the PBT. Conclusion: Our proposed “safe zone” for the approach to the proximal 5MT remains superior to the LDCN and inferior to the AB and avoids crossing directly over either nerve in >95% of analyzed MRI studies. This incision begins 1.5 cm dorsal to the most proximal aspect of the 5MT and extends no more than 1 cm posteriorly. Careful dissection and identification of the LDCN and possible AB is necessary prior to further extension of incision. Level of Evidence: Level IV, case series.
Survival status and predictors of mortality among HIV-positive children initiated antiretroviral therapy in Bahir Dar town public health facilities Amhara region, Ethiopia, 2020
Authors: Chekole Bogale , Belachew Amare , Geddif Azeb , Amsalu Eden , Tigabu Agimasie 
Published: January 2022

Background: Although there is a presence of governmental and non-governmental organizations running to provide quality HIV care services to reduce HIV-related mortality, there is rapid disease progression and death among children in developing countries including Ethiopia. Thus, this study was aimed to assess the mortality predictors of children living with HIV at Bahir Dar town public health facilities. Method: A facility-based retrospective follow-up study was conducted among 588 children who were enrolled in the HIV care clinic from 1 September 2010 to 30 August 2019. Data were entered into the Epi-Data entry 3.1 and then exported to STATA version 14 for analysis. Multiple imputation models were employed to handle missing data using the multivariate imputation Chained Equations technique. The Kaplan–Meier survival curve and log-rank test were used to estimate and compare the survival time of categorical variables. Result: About 27 (4.6%) (95% confidence interval: 2.9–6.5) deaths were observed from the 30,062.3 person-months follow-up period, and the overall incidence density rate of 0.9 per 1000 child-months (95% confidence interval: 0.6–1.3). Advanced WHO clinical stage (adjusted hazard ratio = 3.18; 95% confidence interval: 1.07–9.43), hemoglobin level less than 8 g/dL (adjusted hazard ratio = 3.54; 95% confidence interval: 1.27–8.85), children having a weight for age of <−2z (adjusted hazard ratio = 2.81; 95% confidence interval: 1.19–6.6), children with poor adherence (adjusted hazard ratio = 3.91; 95% confidence interval: 1.41–10.8), and starting the treatment beyond 1 week of being eligible (adjusted hazard ratio = 3.22; 95% confidence interval: 1.21–8.53) were predictors of HIV-related mortality among children initiated antiretroviral therapy. Conclusion: The hazard of mortality was higher among HIV-infected children in the early period of initiation. Enhancing antiretroviral therapy drug adherence, monitoring Hgb level, and timely initiation of antiretroviral therapy reduce HIV-related mortality.