bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gate-based Quantum Computing for Protein Design
Authors: Kim Philip , Khatami Mohammad Hassan , Mendes Udson , Wiebe Nathan 
Published: September 2022

Abstract
Protein design is a technique to engineer proteins by permuting amino acids in the sequence to obtain novel functionalities. However, exploring all possible combinations of amino acids is generally impossible due to the exponential growth of possibilities with the number of designable sites. The present work introduces circuits implementing a pure quantum approach, Grover’s algorithm, to solve protein design problems. Our algorithms can adjust to implement any custom pair-wise energy tables and protein structure models. Moreover, the algorithm's oracle is designed to consist of only adder functions. Quantum computer simulators validate the practicality of our circuits, containing up to 234 qubits. However, a smaller circuit is implemented on real quantum devices. Our results show that using \(\mathcal{O}\left(\sqrt{N}\right)\) iterations, the circuits find the correct results among all N possibilities, providing the expected quadratic speed up of Grover's algorithm over classical methods (i.e., \(\mathcal{O}\text{(}N\text{)}\)).
Quadcopter Attitude Control with Vibration Reduction by Additive-State-Decomposition Dynamic Inversion Design with a Notch Filter
Authors: Chen Lian , Zhang Jing , Quan Quan 
Published: September 2022

Abstract
In practice, the unbalanced mass of the propeller is the leading cause of vibration in a quadcopter. First, a mechanical model of the unbalanced masses is established. Next, consider the vibration reduction problem for quadcopter attitude control. A notch filter is incorporated into to an additive-state-decomposition dynamic inversion controller to obtain a new controller. Stability analysis shows that the proposed control method guarantees that all attitude signals are globally uniformly ultimately bounded. In particular, the notch filter can effectively reduce the vibration having a specific frequency. Finally, the proposed controller is performed on a real quadcopter to verify its vibration reduction performance.
Effects of Conferring Business Resource on Rivals
Authors: Jamison Mark , Ajit Tejaswi Channagiri 
Published: September 2022

Abstract
We examine how requiring platforms to give rivals resources, such as data, affects innovation. There are two firms, one if which is the first to provide the first of two technologies. A second firm adopts the same technology and then both firms are given an opportunity to adopt a second, more valuable technology. The firms do not charge the platform users but do charge entities that value access to the users, perhaps for advertising or to sell products. The value of that access depends on how much knowledge that each platform has accumulated, either from serving users or receiving data from another firm. Users’ willingness to adopt a service follows s-shaped curves that limit the quantities that firms are able to sell. We find that without a data sharing requirement, the second firm adopts the new technology first because it gives up less profit as users migrate from the first technology to the second. Data sharing dampens that incentive and can slow introduction of the new technology. We examine whether it is feasible for regulators to establish a price for data that incentivizes optimal sharing and conclude that the information requirements make finding an efficient price unlikely.
JEL codes: L13, L15, L51
Chronic Supplementation of Noni in Diabetic Type 1-stz Rats: Effects on Glycemic Levels and Exercise Performance
Authors: Fernandes Débora Oliveira , César Fernanda Gracia , Melo Bruno Pereira , Brandao Jéssica Silva Faria , Santos Kelvin Jaques , Andrade Marcelo Teixeira , Casteluber Marisa Cristina Fonseca , Carvalho Moisés Vieira , de Barcellos Luiz Alexandre Medrado , Soares Danusa Dias , Guimaraes Juliana Bohnen 
Published: September 2022

Abstract
Thirty-two male Wistar rats were used to verify the effects of chronic noni juice administration on blood glucose levels and its relation to physical performance. In half of the rats, diabetes mellitus (DM) was induced with STZ, and the rats were submitted to an incremental workload running test (IWT) until fatigued so that oxygen consumption and performance indexes (exercise time to fatigue and workload) could be analyzed before noni administration. Then, the control and DM groups received a placebo (saline solution) or noni juice (dilution 2:1) at a dose of 2 mL/kg once a day for 60 days. The result was four groups: control + placebo (CP), control + noni (CN), DM + placebo (DMP), and DM + noni (DMN). All groups were then given a third IWT to verify the effect of the noni juice on exercise performance and glycemia. Twenty-four hours after the third test, all animals were euthanized and blood and kidneys were removed for posterior analysis. Noni administration improved the time to fatigue and workload in DM rats by reducing hyperglycemia. These results could be associated with an improved energy efficiency promoted by noni ingestion. However, our results provided evidence that chronic noni administration causes kidney damage since elevated glomerular filtration was observed at the same magnitude as the non-treated DM group. In conclusion, chronic noni ingestion promoted glycemic control and improved the performance in DM rats but caused kidney toxicity.
Double balloon device for labor induction in women with and without previous cesarean delivery
Authors: Bleicher Inna , DASHKOVSKY-FELDGORN Marianna , SAGI Shlomi , GUTZEIT Ola , BLUMEN Lihi , Farrago Naama , KHATIB Nizar , ZIPORI Yaniv , VITNER Dana 
Published: September 2022

Abstract

Purpose

Induction of labor (IOL) after cesarean delivery is reasonable option and should be discussed. While IOL has been shown to be superior to expectant management in low-risk nulliparous women, the literature in women after cesarean delivery (CD) is sparse. The aim of our study was to compare IOL between in nulliparous women to women who had IOL after cesarean (TOLAC)

Methods

This was a retrospective cohort study, from two medical centers, that compared between TOLAC and nulliparous women who had IOL with a double balloon device. Inclusion criteria were: singleton pregnancy > 37 + 0 weeks and no contraindication for vaginal delivery. We excluded women who withdrew their consent for TOLAC. Primary outcome was the mode of delivery.

Results:

We compared 161 TOLAC to 1577 nulliparous women. Vaginal delivery rate was 70% in both groups, and CD rate remained similar even after adjusting for confounders (29.8% vs. 28.9%, OR 1.1, 95% CI = 0.76–1.58, p = 0.59). CD due to non-reassuring fetal heart rate (NRFHR) was more common in the TOLAC group (75% vs. 56%, p = 0.014) and CD due to non-progressive labor (NPL) was more likely in the Nulliparous group (45.4% vs. 25%, p = 0.014). Other secondary maternal and neonatal outcomes remained similar between groups.

Conclusion:

Induction of labor, with double balloon device in women with a previous cesarean delivery, results in a similar vaginal delivery rate when compared to nulliparous women, with no additional adverse maternal or neonatal outcome.
Labor progression might be different in these women attempting TOLAC, and if managed accordingly, VBAC can be achieved in a higher rate when given a genuine trial of labor, regardless of a previous vaginal delivery.
Feasibility of simultaneous development of laparoscopic and robotic pancreaticoduodenectomy
Authors: Chao Ying-Jui , Lu Wei-Hsun , Liao Ting-Kai , Su Ping-Jui , Wang Chih-Jung , Lai Chao-Han , Hung Jo-Ying , Su Pei-Fang , Shan Yan-Shen 
Published: September 2022

Abstract
Laparoscopic (LPD) and robotic pancreaticoduodenectomy (RPD) are both challenging procedures. The feasibility and safety of simultaneously developing LPD and RPD remain unreported. We retrospectively reviewed the data of patients undergoing LPD or RPD between 2014 and 2021. A total of 114 patients underwent minimally invasive pancreaticoduodenectomy (MIPD): 39 LPDs and 75 RPDs. The learning process of LPD and RPD were similar. The cutoff points of the learning curve were LPD, 13th patient (the 27th patient of MIPD), and RPD, 18th patient (the 31st patient of MIPD) according the cumulative sum analysis of operative time. A decrease in the operative time was associated with the case sequence (p < 0.001) but not with the surgical approach (p = 0.36). The overall surgical outcomes were comparable between both the LPD and RPD groups. When evaluating the learning curve impact on MIPD, LPD had higher major complication ( ≧ Clavien-Dindo grade III), bile leak and wound infection rates in the pre-learning curve phase than those in the after-learning curve phase, while RPD had similar surgical outcomes between two phases. Simultaneous development of LPD and RPD is feasible and safe for experienced surgeons, with similar learning process and comparable surgical outcomes.
The association between physical symptoms and self-care behaviours in Chinese patients who poorly manage their heart failure: a cross-sectional study
Authors: Liu Xu , Liu Li , Li Yan , Cao Xi 
Published: September 2022

Abstract
Background
Physical symptoms are frequently experienced by patients with heart failure and may affect their self-care. Little is known about the association between physical symptoms and self-care in heart failure patients who are not proficient in managing their illness. The study aimed to explore the association between physical symptoms and self-care behaviours in Chinese patients who poorly managed their heart failure.
Methods
This was a secondary data analysis of a cross-sectional study exploring factors contributing to the self-care of Chinese heart failure patients. Physical symptoms were measured with the Heart Failure Somatic Perception Scale. Self-care behaviours (i.e., self-care maintenance and management) of heart failure were measured with the Self-Care of Heart Failure Index (version 6.2). Patients who reported scores < 70 on both self-care maintenance and management were eligible and included in the analysis. Hierarchical regression analysis was performed to explore the association of physical symptoms with self-care behaviours.
Results
In total, 189 patients were included in this analysis, with a mean age of 65, who had been diagnosed with heart failure for 24 months as the median. Most participants were classified as New York Heart Association class III or IV. Physical symptoms related to dyspnoea were most frequently reported. Severe heart failure physical symptoms were significantly related to better self-care management (β = 0.157, 95% CI: 0.010, 0.368, p = 0.039) rather than self-care maintenance (β = -0.133, 95% CI: -0.316, 0.026, p = 0.097).
Conclusions
Worse physical symptoms may serve as a driver of better self-care management in Chinese heart failure patients with poor self-care behaviours. Tailored care and support taking their physical symptoms into consideration should be provided to patients with different levels of self-care proficiency.
DEHP exposure impairs human skeletal muscle cell proliferation in primary culture conditions
Authors: Brassea-Pérez Elizabeth , Labrada-Martagón Vanessa , Hernández-Camacho Claudia , Gaxiola-Robles Ramón , Vázquez-Medina José Pablo , Zenteno-Savín Tania 
Published: September 2022

Abstract
The plasticizer di (2-ethylhexyl) phthalate (DEHP) inhibits differentiation, impairs glucose metabolism, and decreases mitochondrial function in murine muscle satellite cells; however, if these effects are translated to human cells is unknown. The goal of this study was to evaluate changes in morphology and proliferation of primary human skeletal muscle cells exposed to DEHP. Rectus abdominis muscle samples were obtained from healthy women undergoing programed cesarean surgery. Skeletal muscle cells were isolated and grown under standard primary culture conditions, generating two independent sample groups of 25 subcultures each. Cells from the first group were exposed to 1 mM DEHP for 13 days and monitored for changes in cell morphology, satellite cell frequency and total cell abundance, while the second group remained untreated (control). Differences between treated and untreated groups were compared using generalized linear mixed models (GLMM). Cell membrane and nuclear envelope boundary alterations, loss of cell volume and presence of stress bodies were observed in DEHP-treated cultures. DEHP-treated cultures also showed a significant reduction in satellite cell frequency compared to controls. Exposure to DEHP reduced human skeletal muscle cell abundance. Statistical differences were found between the GLMM slopes, suggesting that exposure to DEHP reduced growth rate. These results suggest that exposure to DEHP inhibits human skeletal muscle cell proliferation, as evidenced by reduced cell abundance, potentially compromising long-term culture viability. Therefore, DEHP induces human skeletal muscle cell deterioration potentially inducing an inhibitory effect of myogenesis by depleting satellite cells.
Fetuin B alleviates testosterone propionate-induced oxidative stress and mitochondrial dysfunction in KGN cells by upregulating the TGFR2/SMAD3 pathway
Authors: Gao Yiyin , Zheng Lianwen , Wu Guijie , Ma Yalan , Zou Yinggang 
Published: September 2022

Abstract

Background Polycystic ovary syndrome (PCOS) is one of the most common reproduction and endocrine disorders. Patients with abnormal follicle growth develop ovulation disorders and amenorrhea, and eventually infertility. The role of Fetuin-B (FETUB), one of the differentially expressed proteins (DEPs) in follicular fluid (FF) of PCOS patients, in pathogenesis of PCOS was not clearly clarified. Methods In this study, we performed iTRAQ-based quantitative proteomic analysis on FF collected from non-PCOS healthy controls and PCOS patients to identify DEPs. In addition, KGN cells treated with testosterone propionate (TP) were used as a model of hyperandrogenism in vitro to investigate the regulatory effects of the selected DEP, FETUB, on cellular processes in KGN cells and its molecular mechanism by detecting steroid hormone secretion, measuring indicators of oxidative stress (OS), mitochondria functions and apoptosis and characterizing the FETUB-altered downstream signaling. Results We found that supplementation with recombinant FETUB could significantly restore the total antioxidant capacity and activity of antioxidant enzymes, which were reduced by treatment with TP. Additionally, FETUB restored the secretory and mitochondrial functions in TP-impaired KGN cells and reduced their apoptosis. Furthermore, our study revealed that FETUB could bind with transforming growth factor beta receptor 2 (TGFR2) on the cell membrane of KGN cells and promote phosphorylation of SMAD3, which had a therapeutic effect against tissue injury and inflammation. And the protective effect of FETUB on TP-treated KGN cells was inhibited by pre-treatment with SB431542 and SIS3, selective inhibitors of TGFR2 and SMAD3, respectively. Conclusions These results indicate that FETUB may protect TP-treated KGN by alleviating OS and mitochondrial dysfunction via the TGFR2-mediated SMAD pathway. Data are available via ProteomeXchange with identifier PXD036531
Correlation of ACE2 and TMPRSS2 expression levels in nasopharyngeal swab samples of COVID-19 patients with disease severity
Authors: Mohammadi Marzieh , Rahimi Amir Abbas , Salehi-Vaziri Mostafa , Sharifnia Fariba , Mehrjerdi Ebrahim Kalantar , Karimipoor Morteza 
Published: September 2022

Abstract
Background: Angiotensin converting enzyme-2 (ACE2) and Transmembrane serine protease 2 (TMPRSS2) are key proteins that serve as receptors and co-receptor in the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infective process, which could affect host susceptibility or severity in response to infection. We evaluated the expression levels of above genes to consider the probable relationship with age, sex, and respiratory distress.
Method and Result: Here, in a case-control study, we compared the expression levels of ACE2 and TMPRSS2 genes in nasopharyngeal swab samples of one hundred Coronavirus disease of 2019 (COVID-19) patients against 50 negative samples. In the positive group, 50 patients selected with mild symptoms and fifty patients were included in the severe / critically ill subgroup We determine the expression levels of ACE2 and TMPRSS2 by Quantitative Real-Time Reverse Transcription PCR (qRT-PCR) and statistical analyzes were implemented to consider the probable relationship between the expression levels of the above genes with sdisease severity, age, and sex. Our results showed ACE2 was down regulated in laboratory-confirmed COVID-19 patients comparing normal control group. In addition, considerable downregulation of ACE2 levels was detected in the severe subgroup compared to mild patients. ACE2 mRNA levels were negatively correlated to age, while there was no significant association between the expression levels of the ACE2 and TMPRSS2 genes and sex. No association was found between the expression levels of TMPRSS2 and the clinical findings of the patients.
Conclusion: This data indicate there is a probable prognostic value of ACE2 expression in the follow-up of the COVID-19 patients.
Physician approval for pregnancy in patients with SLE showing only serological activity: A vignette survey study
Authors: Isojima Sakiko , Yajima Nobuyuki , Yanai Ryo , Miura Yoko , Fukuma Shingo , Kaneko Kayoko , Fujio Keishi , Oku Kenji , Matsushita Masakazu , Miyamae Takako , Wada Takashi , Tanaka Yoshiya , Kaneko Yuko , Nakajima Ayako , Murashima Atsuko 
Published: September 2022

Abstract
Background: The EULAR recommendation requires that the disease activity of systemic lupus erythematosus before pregnancy be stable because pregnancy complications and disease flares increase if pregnancy occurs while systemic lupus erythematosus activity is high. However, some patients have ongoing serological activity even after treatment. Herein, we aimed to investigate how physicians make decisions on the acceptability of pregnancy when patients with systemic lupus erythematosus only have serological activity.
Methods: A questionnaire was administered online to physicians from December 2020 to January 2021. It included the characteristics of physicians, facilities, and the allowance for pregnancies for patients with systemic lupus erythematosus using vignette scenarios.
Results: The questionnaire was distributed to 4,946 physicians, and 9.4% of physicians responded. The median age of respondents was 46 (range: 38–54) years, and 85% were rheumatologists. Pregnancy allowance was significantly affected by duration of the stable period, and mild or high serological activity, respectively (duration: proportion difference, 11.8 percentage points [p.p.]; p < 0.001; mild: proportion difference, -25.8 p.p; p < 0.001; high: -65.6 p.p.; p < 0.001). Even though patients had a high level of serological activity, 20.5% of physicians allowed pregnancy if there were no clinical symptoms for six months.
Conclusions: Serological activity had a significant effect on physician judgment on the acceptability of pregnancy. Conversely, some physicians allowed patients who only had serological activity to become pregnant. Further observational studies are required to clarify the prognosis of such patients.
The genetic and evolution characterization of the gut microbiota in pigs
Authors: Zhang Shuhong , Zhang Huan , Zhang Cheng , Wang Guan , Shi Chuanxing , Li Zhiqiang , Gao Fengyi , Cui Yanyan , Li Ming , Yang Guangli 
Published: September 2022

Abstract
Intestinal microbiota plays significant roles in the physiology and functioning of their host organisms. However, there is limited knowledge of the evolution and genetic of microbiota-host relationships from wild ancestors to modern domesticated species. In this study, the 16S rRNA gene V3 -V4 was analyzed by high-throughput sequencing in the intestinal contents of different pig breeds which were then compared. This identified 18 323 amplicon sequence variants, of which the Firmicutes and Actinobacteria phyla and Bifidobacterium and Allobaculum genera were most prevalent in wild pigs (WP). In contrast, Proteobacteria and Firmicutes predominated in Chinese Shanxi Black pigs (CSB), while Firmicutes were the most prevalent phylum in Large White pigs (LW) and Iberian pigs (IB), followed by Bacteroidetes in IB and Proteobacteria in LW. At the genus level, Shigella and Lactobacillus were most prevalent in CSB and LW, while Actinobacillus and Sarcina predominated in IB. Differential gene expression together with phylogenetic and functional analyses indicated significant differences in the relative abundance of microbial taxa between different pig breeds. Although many microbial taxa were common to both wild and domestic pigs, significant diversification was observed in bacterial genes that may influence host phenotypic traits. Overall, these findings suggested that both the composition and functional of the microbiota were closely associated with the domestication and resultant genetic and evolutionary changes in the host. The members of the microbial communities were vertically transmitted in pigs, with evidence of co-evolution of both the hosts and their intestinal microbial communities. These results enhance our understanding and appreciation of the complex interactions between intestinal microbes and hosts and highlight the importance of applying this knowledge in agricultural and microbiological research.
Characterization and release modelling of fish gelatin/succinic anhydride starch nanocomposite films containing Stureja Khuzestanica Jamzad essential oil
Authors: Dakhili Samira , Yekta Reza , Mohammadi Abdorreza , karimian-Khosroshahi Nader , Hosseini Seyede Marzieh , Shojaee-Aliabadi Saeedeh 
Published: September 2022

Abstract
Fish gelatin (FG) and succinic anhydride starch (OSAS) composite films loaded with 1, 2, 3 and 4 wt% bacterial nanocellulose (BNC) and Stureja Khuzestanica Jamzad essential oil (SKEO) were achieved successfully and their physicochemical and release properties were investigated. The results revealed that by enhancing the BNC concentration until 4 wt% the water solubility and water vapor permeability of samples increased significantly (p < 0.05) due to the hydrophilicity of BNC. Moreover, incorporation of BNC improved the tensile strength from 3.81 in control film to 7.03 in film containing 4 wt% BNC which was also confirmed with FE-SEM, FTIR and XRD. FE-SEM approved the reduction of small cracks within the structure of film samples with the incorporation of both BNC and films became more homogeneous. Study the release profile of SKEO in 4 and 37 ̊ C from nanocomposite films revealed that incorporating 4 wt% BNC had the most controlling effect on release of SKEO and the dominant release mechanism was the Fickian diffusion. This research demonstrated the FG/OSAS nanocomposite films containing SKEO would be a suitable candidate for active food packaging.