bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new slip surface in noncohesive slopes
Authors: Repadi J A , Bari F , Ismail F A , Andriani A , Hakam A 
Published: January 2022

Abstract
Determining the slope slip surface is difficult, prominent and uncertain. Slip-surface are utilized to estimate slope safety. This study aimed at investigating the slip surface caused by statistical loads by using experimental testing methods. The experimental method was conducted by providing a statistical load on the sand slope The load was used until the slope collapsed. Sand slopes were modeled in a glass box measuring 110 cm x 40 cm x 10 cm. The sand material used was sand that passed through sieve no.10 and was held by sieve no. 200. At a distance of 2.5 cm horizontally and at a distance of 5 cm vertically, colored marks were used to see the pattern of grain movement. Observations were conducted until the slope collapsed. The collapse pattern revealed in the experimental method is non-circular.
Potential of tidal power plants with least square method on Toaya Beach
Authors: Azikin H , Nurhidayat  , Affandy E , Syahruddin S S 
Published: January 2022

Abstract
The use of energy, especially electrical power, is needed by the wider community— lots of alternative energy from nature, especially in Indonesia that can be utilized to produce electricity. One of the newest alternative examples is the energy produced by tides. Tidal energy is a type of renewable energy that is relatively more predictable in number. One method that can process the waves is the Least Square Method. Where the results of data processing using this method can be known based on tidal observations for 15 days on Toaya Beach located in Donggala Regency, Central Sulawesi, the types of tidal types that occur based on the results of Formzahl’s count is 0.357 that the tidal types that occur are varied types leaning to double daily, with a Root Mean Square Error (RMSE) of 0.028, which means that the difference between predictive results and observational data is accurate. Then also obtained the value of the design water level elevation that is the highest high water level (HHWL) is 2.7 meters, and the lowest low water level (LLWL) is -0.3 meters with a height difference is 3.0 meters. So with the high height difference, the total energy generated by two times a day with a sea area of 9 km2 which is capable of producing energy movement from seawater can be calculated the potential energy generated from the waves of Toaya Beach, which is 5,53 MW.
Centralised and decentralised data communication scheme for voltage regulation in DC Microgrids
Authors: Setiawan M A , Sulistyo E 
Published: January 2022

Abstract
Voltage regulation is one of the main control issues in DC Microgrids (MGs). To achieve voltage regulation in MGs, exchange information between distributed generation units (DG) is inevitable. There are two types of data exchange proposed and discussed, centralised and decentralised data communication schemes. Many papers in the literature did not give attention to the type of data communication infrastructure that will have a significant impact on both centralised and decentralised schemes. This paper proposes centralised and decentralised data communication scheme and their impact on voltage regulation in DC MGs. The dynamic performance of a DC MG with loads fluctuations, operating with the proposed technique, is evaluated through simulation analyses, realized in MATLAB. Both the proposed centralised and decentralised methods are able to maintain the voltage within acceptable limit during loads fluctuations; however the centralised method is around five times faster than the decentralised method. The results show the superiority of the proposed method for the DC MGs operations during load demands fluctuations, loads varieties, communication delays and structures.
loT-based temperature and humidity monitoring system for smart garden
Authors: Yanshori  , Nugraha D W , Santi D 
Published: January 2022

Abstract
The main objective of this paper is to design an IoT (Internet of Things) to monitor temperature and humidity for smart gardens. Temperature sensors and humidity sensors measure environmental conditions and are processed by a microcontroller. The actuator used is a spray pump that is used to spray water into the air to lower the temperature. Data from the sensors and status from the actuators are sent to the server and can be monitored via a smartphone. The data collected can be analyzed for various purposes. The result obtained is the effect of spraying on temperature reduction.
Designing simulation model for minimizing coal train unloading time: A case study of Kereta Api Logistik Company
Authors: Wijaya H , Ridwan A Y , Setyawan E B 
Published: January 2022

Abstract
The increase in coal production every year has influence the transport volume of coal trains of Kereta Api Logistik Company is getting higher. This increase causes the current number of train unloading equipment to be unable to keep up with this increase and has an impact on the poor performance of train unloading, which is indicated by the unachieved of train’s waiting time target. The coal train unloading system is a very complex system and many uncertainties occur, so the appropriate method to use is discrete event simulation. The simulation model is designed using the Simulation Arena software. The results of the simulation method are 4 alternative scenarios will be selected by the Bonferonni test. Scenario 4 has the highest reduction in train unloading operating time, which is 30.7%. The results of this study recommend the addition of a tool with a combination of 1 unit of Gantry Crane integrated with coal traveling hopper and 5 units of Dump Truck and for management, this recommendation can reduce high overtime costs every month and increase coal transport capacity so that coal transport profits will increase.
Survival and adverse events in patients with atrial fibrillation at left ventricular assist device implantation: an analysis of the European Registry for Patients with Mechanical Circulatory Support
Authors: Antonides Christiaan F J , Yalcin Yunus C , Veen Kevin M , Muslem Rahatullah , De By Theo M M H , Bogers Ad J J C , Gustafsson Finn , Caliskan Kadir 
Published: January 2022

Abstract

OBJECTIVES
Atrial fibrillation (AF) is a risk factor for mortality and cerebrovascular accidents (CVAs) and is common in patients with heart failure. This study evaluated survival and adverse events in patients with a left ventricular assist device (LVAD) and a history of AF in the European Registry for Patients with Mechanical Circulatory Support.

METHODS
Patients with a continuous-flow LVAD, AF or sinus rhythm (SR) and a follow-up were included. Kaplan–Meier analyses for survival (including a propensity-scored matched analysis), freedom from CVA, pump thrombosis, bleeding and a composite of pump thrombosis/CVA were performed. To correct for covariate imbalance, a Kaplan-Meier (KM) analysis was performed after propensity score (PS) matching the groups. Finally, a Cox regression was performed for predictors of lower survival.

RESULTS
Overall, 1821 patients (83% male) were included, with a median age of 57 years and a median follow-up of 13.1 months (interquartile range: 4.3–27.7). Preoperative Electrocardiogram (ECG) rhythm was AF in 421 (23.1%) and SR in 1400 (76.9%) patients. Patients with pre-LVAD AF had a lower ≤90-day (81.9% vs 87.1%, P = 0.0047) and 4-year (35.4% vs 44.2%, P = 0.0083) survival compared to SR. KM analysis with PS matching groups revealed a trend (P = 0.087) towards decreased survival. Univariable analyses confirmed pre-LVAD AF as a predictor for mortality, but the multivariable analysis did not. No difference in the rate of adverse events was found. An analysis of patients at 24 months revealed a higher rate of CVAs for pre-LVAD AF patients (77% vs 94.3%, P &lt; 0.0001).

CONCLUSIONS
Patients with pre-LVAD AF undergoing LVAD implantation had a worse survival. However, after performing a multivariate analysis, and PS matching analysis, AF was no longer significant, indicating a worser preoperative condition in these patients. Concerning thrombo-embolic events, only patients with pre-LVAD AF alive beyond 24 months have a higher risk of CVAs.
Circulatory hepcidin levels association with gestational diabetes mellitus: a meta-analysis of observational studies
Authors: Meka Soumya , Geddamuri Bala Ganesh , Varghese Bincy , Nath Bishamber , Vishwakarma Gayatri , Adela Ramu 
Published: January 2022

Abstract

Objectives
Hepcidin is linked to glucose metabolism in women with gestational diabetes mellitus (GDM). This systematic review and meta-analysis was conducted to determine the association between hepcidin levels and GDM. A literature search was performed using different databases to identify potential studies investigating hepcidin association in GDM patients. The effect sizes were calculated based on the standardized mean difference (SMD) and Fisher’s Z value with a 95% confidence interval (CI).

Key findings
Out of 827 articles, only 7 case–control studies satisfied the inclusion and exclusion criteria. The pooled SMD of circulatory hepcidin levels in GDM patients was considerably higher than normal pregnant women (SMD = 1.69; 95% CI, 0.86 to 2.53; P &lt; 0.0001). This study also observed that hepcidin levels were positively correlated with ferritin levels (r = 0.264; Z = 0.27; P &lt; 0.0001). Furthermore, a subgroup analysis of serum and plasma groups revealed significantly higher hepcidin levels in serum (SMD = 2.12; 95% CI, 0.44 to3.79; P = 0.001) than in the plasma group (SMD = 1.28; 95% CI, 0.32 to 2.2; I2 = 96%).

Summary
Our findings suggest that hepcidin levels may be elevated in GDM patients, making it a viable marker for GDM diagnosis, and regular monitoring of its levels could be helpful in aiding clinical decisions.
Constraints on compact binary merger evolution from spin-orbit misalignment in gravitational-wave observations
Authors: Gompertz B P , Nicholl M , Schmidt P , Pratten G , Vecchio A 
Published: January 2022

ABSTRACT
The identification of the first confirmed neutron star–black hole (NS-BH) binary mergers by the LIGO, Virgo, and KAGRA collaboration provides the opportunity to investigate the properties of the early sample of confirmed and candidate events. Here, we focus primarily on the tilt angle of the BH’s spin relative to the orbital angular momentum vector of the binary, and the implications for the physical processes that determine this tilt. The posterior tilt distributions of GW200115 and the candidate events GW190426_152155 and GW190917_114630 peak at significantly anti-aligned orientations (though display wide distributions). Producing these tilts through isolated binary evolution would require stronger natal kicks than are typically considered (and preferentially polar kicks would be ruled out), and/or an additional source of tilt such as stable mass transfer. The early sample of NS-BH events are less massive than expected for classical formation channels, and may provide evidence for efficient mass transfer that results in the merger of more massive NS-BH binaries before their evolution to the compact phase is complete. We predict that future gravitational-wave detections of NS-BH events will continue to display total binary masses of ≈7 M⊙ and mass ratios of q ∼ 3 if this interpretation is correct. Conversely, the high mass of the candidate GW191219_163120 suggests a dynamical capture origin. Large tilts in a significant fraction of merging NS-BH systems would weaken the prospects for electromagnetic detection. However, EM observations, including non-detections, can significantly tighten the constraints on spin and mass ratio.
Duplication and Specialization of NUDX1 in Rosaceae Led to Geraniol Production in Rose Petals
Authors: Conart Corentin , Saclier Nathanaelle , Foucher Fabrice , Goubert Clément , Rius-Bony Aurélie , Paramita Saretta N , Moja Sandrine , Thouroude Tatiana , Douady Christophe , Sun Pulu , Nairaud Baptiste , Saint-Marcoux Denis , Bahut Muriel , Jeauffre Julien , Hibrand Saint-Oyant Laurence , Schuurink Robert C , Magnard Jean-Louis , Boachon Benoît , Dudareva Natalia , Baudino Sylvie , Caissard Jean-Claude 
Published: January 2022

Abstract
Nudix hydrolases are conserved enzymes ubiquitously present in all kingdoms of life. Recent research revealed that several Nudix hydrolases are involved in terpenoid metabolism in plants. In modern roses, RhNUDX1 is responsible for formation of geraniol, a major compound of rose scent. Nevertheless, this compound is produced by monoterpene synthases in many geraniol-producing plants. As a consequence, this raised the question about the origin of RhNUDX1 function and the NUDX1 gene evolution in Rosaceae, in wild roses or/and during the domestication process. Here, we showed that three distinct clades of NUDX1 emerged in the Rosoidae subfamily (Nudx1-1 to Nudx1-3 clades), and two subclades evolved in the Rosa genus (Nudx1-1a and Nudx1-1b subclades). We also showed that the Nudx1-1b subclade was more ancient than the Nudx1-1a subclade, and that the NUDX1-1a gene emerged by a trans-duplication of the more ancient NUDX1-1b gene. After the transposition, NUDX1-1a was cis-duplicated, leading to a gene dosage effect on the production of geraniol in different species. Furthermore, the NUDX1-1a appearance was accompanied by the evolution of its promoter, most likely from a Copia retrotransposon origin, leading to its petal-specific expression. Thus, our data strongly suggest that the unique function of NUDX1-1a in geraniol formation was evolved naturally in the genus Rosa before domestication.
Outcome predictors of immune-mediated necrotizing myopathy—a retrospective, multicentre study
Authors: Wang Jeremy X , Wilkinson Michael , Oldmeadow Christopher , Limaye Vidya , Major Gabor 
Published: January 2022

Abstract

Objectives
Evidence-based treatment protocols are currently lacking for immune-mediated necrotizing myopathy (IMNM). In this multicentre retrospective study, we examined baseline clinical characteristics and treatment variables that may predict short-term outcomes of patients with IMNM.

Methods
Muscle biopsies from the John Hunter Hospital and the Royal Adelaide Hospital obtained between 2012 and 2019 were reviewed at a single laboratory at South Australia Pathology. All biopsies with histological features of IMNM were identified. Demographics of study subjects, clinical information and myositis-specific antibody status were recorded along with muscle strength, serum creatine kinase (CK) and treatment regimens at baseline and 3 and 6 months. Primary outcome measures were muscle strength and serum CK at 3 and 6 months. Mixed-effects regression models in a Bayesian framework were performed using the R statistical package.

Results
Female sex, older age, initial prednisone dose and i.v. methylprednisolone were associated with greater improvement in serum CK. In patients with moderate–severe disease at baseline, early IVIG was associated with greater improvement in hip flexor strength at 6 months.

Conclusion
Early IVIG was associated with clinical improvement in the short-term follow-up in IMNM. Female sex, older age, initial oral prednisone dose and initial use of i.v. methylprednisolone were associated with better biochemical improvement.
Hyperresponsive cytosolic DNA-sensing pathway in monocytes from primary Sjögren’s syndrome
Authors: Huijser Erika , Bodewes Iris L A , Lourens Mirthe S , van Helden-Meeuwsen Cornelia G , van den Bosch Thierry P P , Grashof Dwin G B , van de Werken Harmen J G , Lopes Ana P , van Roon Joel A G , van Daele Paul L A , Brkic Zana , Dik Willem A , Versnel Marjan A 
Published: January 2022

Abstract

Objectives
Cytosolic DNA-sensing pathway stimulation prompts type I IFN (IFN-I) production, but its role in systemic IFN-I pathway activation in primary SS (pSS) is poorly studied. Here we investigate the responsiveness of pSS monocytes and plasmacytoid dendritic cells (pDCs) to stimulator of interferon genes (STING) activation in relation to systemic IFN-I pathway activation and compare this with SLE.

Methods
Expression of DNA-sensing receptors cGAS, IFI16, ZBP-1 and DDX41, signalling molecules STING, TBK1 and IRF3, positive and negative STING regulators, and IFN-I-stimulated genes MxA, IFI44, IFI44L, IFIT1 and IFIT3 was analysed in whole blood, CD14+ monocytes, pDCs, and salivary glands by RT-PCR, monocyte RNA sequencing data, flow cytometry and immunohistochemical staining. Peripheral blood mononuclear cells (PBMCs) from pSS, SLE and healthy controls (HCs) were stimulated with STING agonist 2′3′-cGAMP. STING phosphorylation (pSTING) and intracellular IFNα were evaluated using flow cytometry.

Results
STING activation induced a significantly higher proportion of IFNα-producing monocytes, but not pDCs, in both IFN-low and IFN-high pSS compared with HC PBMCs. Additionally, a trend towards more pSTING+ monocytes was observed in pSS and SLE, most pronounced in IFN-high patients. Positive STING regulators TRIM38, TRIM56, USP18 and SENP7 were significantly higher expression in pSS than HC monocytes, while the dual-function STING regulator RNF26 was downregulated in pSS monocytes. STING was expressed in mononuclear infiltrates and ductal epithelium in pSS salivary glands. STING stimulation induced pSTING and IFNα in pSS and SLE pDCs.

Conclusion
pSS monocytes and pDCs are hyperresponsive to stimulation of the STING pathway, which was not restricted to patients with IFN-I pathway activation.
A Within-Subject Before-After Study of the Impact of Antidepressants on Hemoglobin A1c and Low-Density Lipoprotein Levels in Type 2 Diabetes
Authors: Rohde Christopher , Thomsen Reimar W. , Østergaard Søren D. 
Published: January 2022

Abstract

Purpose/Background
Data on the effect of treatment with antidepressant drugs on metabolic control in diabetes are sparse. In this controlled within-subject before-after study, the impact of initiation and discontinuation of antidepressant treatment on hemoglobin A1c (HbA1c) and low-density lipoprotein (LDL) levels in type 2 diabetes was estimated.

Methods/Procedures
All individuals with newly developed type 2 diabetes (first HbA1c ≥ 6.5%) between 2000 and 2016 in Northern and Central Denmark were identified using register-based health care data. Among these, we identified individuals initiating and discontinuing antidepressant treatment. Using a within-subject before-after design, we examined HbA1c and LDL in the 16 months leading up to and the 16 months after antidepressant treatment initiation or discontinuation, respectively. For comparison, we ran similar time trend analyses in a reference population of age- and sex-matched type 2 diabetes individuals not receiving antidepressant treatment.

Findings/Results
Mean HbA1c decreased after initiation of antidepressant treatment (−0.16%; 95% confidence interval [CI], −0.18 to −0.13%). In the reference population, no material change in HbA1c over time (−0.03%; 95% CI, −0.04 to −0.01%) was seen. Mean LDL decreased not only in antidepressant initiators (−0.17 mmol/L; 95% CI, −0.19 to −0.15 mmol/L) but also in the reference population (−0.15 mmol/L; 95% CI, −0.16 to −0.13 mmol/L). Among antidepressant discontinuers, there was also a decrease in HbA1c (−0.32%; 95% CI, −0.37 to −0.28%), with no change in the reference population (−0.02%; 95% CI, −0.04 to 0.00%). Decreases in LDL were found both in antidepressant discontinuers (−0.09 mmol/L; 95% CI, −0.14 to −0.04 mmol/L) and in the reference population (−0.16 mmol/L0; 95% CI, −0.18 to −0.13 mmol/L).

Implications/Conclusions
Antidepressant treatment in type 2 diabetes may have a beneficial effect on glycemic control, as the decrease in HbA1c after discontinuation of antidepressants likely reflects remission of depression. Conversely, antidepressant treatment does not seem to affect LDL levels.
Monthly Trauma Training and Simulation Are Associated With Improved Resident Skill and Leadership
Authors: Park Caroline , Lin I-Chun , Grant Jennifer L. , Dultz Linda A. , Johnson Della , Jeter Shannon , Abdelfattah Kareem , Luk Stephen , Cripps Michael , Dumas Ryan P. 
Published: January 2022

BACKGROUND:
Training for trauma procedures has been limited to infrequent courses with little data on longitudinal performance, and few address procedural and leadership skills with granular assessment. We implemented a novel training program that emphasized an assessment of trauma resuscitation and procedural skills.

OBJECTIVE:
This study aimed to determine whether this program could demonstrate improvement in both skill sets in surgical trainees over time.

METHODS:
This was a prospective, observational study at a Level I trauma center between November 2018 and May 2019. A procedural skill and simulation program was implemented to train and evaluate postgraduate year (PGY) 1–5 residents. All residents participated in an initial course on procedures such as tube thoracostomy and vascular access, followed by a final evaluation. Skills were assessed by the Likert scale (1–5, 5 noting mastery). PGY 3s and above were additionally evaluated on resuscitation. A paired t test was performed on repeat learners.

RESULTS:
A total of 40 residents participated in the structured procedural skills and simulation program. Following completion of the program, PGY-2 scores increased from a Mdn [interquartile range, IQR] 3.0 [2.5–4.0] to 4.5 [4.2–4.5]. The PGY-3 scores increased from a Mdn [IQR] 3.95 [3.7–4.6] to 4.8 [4.6–5.0]. Eighteen residents underwent repeat simulation training, with Mdn [IQR] score increases in PGY 2s (3.7 [2.5–4.0] to end score 4.47 [4.0–4.5], p = .03) and PGY 3s (3.95 [3.7–4.6] to end score 4.81 [4.68–5.0], p = .04). Specific procedural and leadership skills also increased over time.
Anorectal Manometry in Children
Authors: Strisciuglio Caterina , Banasiuk Marcin , Salvatore Silvia , Borrelli Osvaldo , Staiano Annamaria , Van Wijk Michiel , Vandenplas Yvan , Benninga Marc A. , Thapar Nikhil 
Published: January 2022

ABSTRACTAnorectal disorders are common in children. They are related to structural and/or functional abnormalities of the anorectum or pelvic floor with a variety of symptoms. Therefore, diagnostic tests to evaluate anorectal function can help to better understand the underlying pathophysiology and aetiology as well as facilitate patient management. During the past decades, substantial efforts have been made to improve anorectal function testing; however, more advanced investigations might lead to difficulties in interpretation. Additionally, a great diversity of equipment and protocols are used among centres, which may lead to heterogeneous interpretation of results. More studies to standardize methods of testing and validate reference values are strongly recommended in children. This review updates on the current indications and the protocol of anorectal manometry.