bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular epidemiology of hepatitis A outbreaks and sporadic cases, Latvia, 2017 to 2019
Authors: Savicka Oksana , Zeltmatis Reinis , Storozenko Jelena 
Published: March 2022

Background
Hepatitis A is an acute infection of the liver caused by hepatitis A virus (HAV). Molecular detection and typing of the HAV VP1/P2A genomic region is used for genotyping and outbreak investigations. After a large hepatitis A outbreak in Latvia in 2007–08, only sporadic cases were registered until 2017 when a rise in cases occurred. During 2017–19, 179 laboratory-confirmed hepatitis A cases were notified in Latvia.

Aim
To investigate the observed increase in hepatitis A cases during 2017 and to determine whether these cases were linked to one another, to risk groups, or to other outbreaks. The majority of HAV samples (69.8%) were typed.

Methods
The VP1/P2A genomic region of HAV was amplified and sequenced for 125 case serum samples. Information about hepatitis-related symptoms, hospitalisation, vaccination, a possible source of infection and suspected countries of origin of the virus were analysed for sequenced cases.

Results
Most HAV strains were subgenotype IA (n = 77), of which 41 were strains circulating among men who have sex with men (MSM) populations in Europe (VRD_521_2016 (n = 32), RIVM-HAV16–090 (n = 7) or V16–25801 (n = 2)). Forty-four cases were subgenotype IB and four cases subgenotype IIIA. However, other clusters and sporadic cases were detected with or without identifying the epidemiological link.

Conclusion
This work represents molecular epidemiological data of hepatitis A cases in Latvia from 2017 to 2019. Molecular typing methods allow identification of clusters for public health needs and establishing links with other outbreaks, and to compare Latvian strains with reported strains from other countries.
PENGARUH SPIRITUAL EMOTIONAL FREEDOM TECHNIQUE (SEFT) TERHADAP VITAL SIGN PADA PASIEN GAGAL GINJAL
Authors: Evinda Rizky Nur , Milwati Susi , Yudiernawati Atti 
Published: March 2022

Abstrak: Tujuan penelitian ini adalah untuk mengetahui pengaruh spiritual emotional freedom tehnique (SEFT) terhadap vital sign pada pada pasien gagal ginjal di RSUD Ngudi Waluyo. Desain penelitian ini adalah quasi eksperiment dengan time series design. Populasi adalah semua pasien gagal ginjal di RSUD Ngudi Waluyo, sedangkan sampelnya adalah sebagian dari populasi yang memenuhi kriteria inklusi sebanyak 29 responden. Teknik sampling yang digunakan adalah non probability sampling dengan spesifikasi purposive sampling. Teknik pengumpulan data dengan pengukuran vital sign sebelum dan sesudah diberikan perlakuan. Pengolahan dan analisa data yang digunakan dalam penelitian ini adalah dengan Uji Wilcoxon. Hasil analisa data menunjukkan ada pengaruh spiritual emotional freedom technique (SEFT) terhadap vital sign pada pasien gagal ginjal di RSUD Ngudi Waluyo (nilai p = 0,000 atau p<Î±).
Kata kunci : SEFT, vital sign, pasien gagal ginjal
HUBUNGAN TINGKAT PENGETAHUAN KELUARGA DENGAN TINGKAT RESIKO GPPH DI TK MUSLIMAT NURUL ANWAR DESA TALANGAGUNG
Authors: Fitri Ika Mauditya , Nurbadriah Wiwit Dwi , Kumalasari Galuh 
Published: March 2022

Child health development education about GPPH is very important given to families. Therefore, with the existence of health education, the incidence of GPPH in children can be reduced through the role of families in early detection of their children. This study also aims to determine the relationship between the level of family knowledge and the level of GPPH in Muslimat Nurul Anwar Kindergarten, Talangagung Village, Kepanjen District. The design of this research is Non-Experimental with Cross Sectional approach. The sampling technique uses purposive sampling with a total of 43 respondents. The results showed that of 43 respondents who had knowledge of 51.16% and had children who were at high risk of GPPH as many as 62.8%. The instrument used was a closed questionnaire with 49 questions. The statistical test uses the Spearman Rank Test which shows the magnitude of the correlation coefficient between the two variables namely 0.838 with a significance of 0.029, which means there is a significant relationship between the level of family knowledge with the level of GPPH. It can be concluded that if family knowledge about early detection of GPPH is good then the level of GPPH in children can be suppressed. So the respondent is expected to be able to apply the knowledge gained to detect their children's growth and development abnormalities, especially regarding GPPH.
Keywords: GPPH, Early Detection, Knowledge, Family.
PENGARUH HAND MASSAGE TERHADAP TINGKAT KECEMASAN PASIEN PRE OPERASI PADA PEMBEDAHAN ELEKTIF
Authors: Baderiyah Azizatul , Pitoyo Joko , Setyarini Anggun 
Published: March 2022

Rata-rata pasien yang akan menjalani prosedur operasi memerlukan upaya khusus untuk menjaga kestabilan kondisi saat sebelum menjalani tindakan. Seringkali pasien sebelum operasi merasakan kecemasan yang dapat berisiko menimbulkan masalah dan dapat mempengaruhi proses operasi berlangsung serta dapat terjadi penundaan operasi. Studi ini dilakukan untuk mengetahui pengaruh hand massage terhadap tingkat kecemasan pasien pre operasi pada pembedahan elektif. Penelitian ini menggunakan metode literature review dengan strategi penelitian menggunakan PICOS framework. Kemudian diseleksi menggunakan diagram PRISMA sehingga didapattkan delapan jurnal. Jurnal diambil dari database ScienceDirect, Pubmed dan Google schollar. Penilaian kualitas delapan artikel menggunakan JBI Critical Appraisal tools kemudian jurnal dianalisis satu persatu dibuat ringkasan, dicari persamaan dan perbedaanya, penelitian yang saling mendukung, penelitian yang saling bertentangan, dan kemudian dilakukan pembahasan untuk dapat menarik kesimpulan. Data disajikan dalam bentuk narasi dan tabel. Hasil penelitian sebagian besar besar menggunakan desain Randomized Control Trial, sampel diatas 80 responden, 4 studi di Iran, 2 studi di USA, 1 studi di Turki, dan 1 studi di Cina. Pasien pre operasi yang sedang menunggu dilakukannya operasi, 4 jenis operasi diantaranya adalah; operasi general, mata, jantung, dan ambulasi, jumlah responden rata-rata 50-100 individu, usia rata-rata 41-66 tahun, mayoritas responden merasakan kecemasan pre operasi berskala sedang. Kesimpulan penelitian menunjukkan bahwa terdapat pengaruh hand massage terhadap tingkat kecemasan pasien pre operasi pada pembedahan elektif. Tingkat kecemasan pada pasien yang akan menjalani operasi dapat menurun dengan adanya dukungan yang suportif terhadap dirinya salah satunya adalah melalui hand massage.
Kata Kunci : Hand Massage, Pre Operative Elective, Anxiety
DETERMINAN GEJALA KEJADIAN DISMENORE PADA MAHASISWI UNIVERSITAS MUHAMMADIYAH PROF. DR. HAMKA JAKARTA
Authors: Hidayanti Nabila , Adiwiryono Retno Mardhiati 
Published: March 2022

Pada umumnya dismenore dialami oleh usia menarche atau kalangan remaja. Namun, usia dewasa seperti mahasiswa masih banyak yang mengalami kejadian dismenore. Tujuan penelitian untuk mengetahui determinan gejala kejadian dismenore pada mahasiswi Universitas Muhammadiyah Prof. DR. HAMKA tahun 2020. Penelitian ini merupakan penelitian kuantitatif dengan pendekatan Cross Sectional. Populasi penelitian ini yaitu mahasiswi strata 1 dan D3 Universitas Muhammadiyah Prof. DR. HAMKA tahun. Teknik pengambilan sampel menggunakan teknik quota sampling dengan jumlah sampel sebanyak 150 responden. Hasil Univariat menunjukkan gejala kejadian dismenore 135 atau 90,0 persen, usia menarche normal 147 atau 98,0 persen, lama menstruasi normal 116 atau 77,3 persen, siklus menstruasi tidak normal 105 atau 70,0 persen, persepsi laju menstruasi 120 atau 80,0 persen, riwayat keluarga 116 atau 77,3 persen, kebiasaan olahraga tidak teratur 128 atau 85,3 persen, dan stress 139 atau 92,7 persen. Hasil bivariat menunjukkan bahwa terdapat hubungan antara riwayat keluarga dengan gejala kejadian dismenore atau p value 0.003, adanya hubungan antara siklus menstruasi dengan gejala kejadian dismenore atau p value 0.038, dan adanya hubungan antara persepsi laju menstruasi dengan gejala kejadian dismenore atau p value 0.041. Berdasarkan hasil penelitian disarankan, untuk fakultas diluar fakultas kesehatan bisa diberikan juga materi terkait kesehatan untuk para mahasiswinya agar lebih siap dalam menjaga kesehatan
The Effectiveness of Breath Relaxation with Balloon Blowing Technique towards Oxygen Saturation of COPD Patients
Authors: Tunik Tunik , Niningasih Rahayu , Yuswantoro Edi 
Published: March 2022

Physiology and psychology are problems which statistically experienced by the patients of COPD and decrease their quality of life. Breathing Relaxation with Balloon Blowing Technique is one the best breathing exercises to regain the function of lungs. The objective of this thesis was to measure the effectiveness of breathing relaxation with balloon blowing technique towards oxygen saturation. The research design used in this thesis was pre experiment with pre post test one design. The sample of the thesis was thirty respondents of COPD patients of Flamboyan room in dr. Soedomo hospital. The sampling technique used in this research was consecutive sampling technique. It was consisted of a group of intervention. Pre test and post test were used to collect the data of the research on the third and seventh day. The result were tested using Repeated ANOVA test. The research showed that there was a significant result to oxygen saturation, before and after doing intervention on the third and seventh day. The result of statistical analysis showed the p value was smaller than 0.05 at the oxygen saturation, on the third and seventh day. Breathing relaxation with balloon blowing technique can increase the oxygen saturation patient with COPD
The role of vagus nerve stimulation in genetic etiologies of drug-resistant epilepsy: a meta-analysis
Authors: Hajtovic Sabastian , LoPresti Melissa A. , Zhang Lu , Katlowitz Kalman A. , Kizek Dominic J. , Lam Sandi 
Published: March 2022

OBJECTIVE
Drug-resistant epilepsy (DRE) affects many children. Vagus nerve stimulation (VNS) may improve seizure control; however, its role in children with genetic etiologies of epilepsy is not well described. The authors systematically reviewed the literature to examine the effectiveness of VNS in this cohort.

METHODS
In January 2021, the authors performed a systematic review of the PubMed/MEDLINE, SCOPUS/Embase, Cochrane, and Web of Science databases to investigate the impact of VNS on seizure outcomes in children with genetic etiologies of epilepsy. Primary outcomes included seizure freedom rate, ≥ 90% seizure reduction rate, and ≥ 50% seizure reduction rate. Secondary outcomes were seizure severity and quality of life (QOL), including cognitive, functional, and behavioral outcomes. A random-effects meta-analysis was performed.

RESULTS
The authors identified 125 articles, of which 47 with 216 nonduplicate patients were analyzed. Common diagnoses were Dravet syndrome (DS) (92/216 patients [42.6%]) and tuberous sclerosis complex (TSC) (63/216 [29.2%]). Seizure freedom was not reported in any patient with DS; the pooled proportion (95% CI) of patients with ≥ 50% seizure reduction was 41% (21%–58%). Secondary cognitive outcomes of VNS were variable in DS patients, but these patients demonstrated benefits in seizure duration and status epilepticus. In TSC patients, the pooled (95% CI) seizure freedom rate was 40% (12%–71%), ≥ 90% seizure reduction rate was 31% (8%–56%), and ≥ 50% reduction rate was 68% (48%–91%). Regarding the secondary outcomes of VNS in TSC patients, several studies reported decreased seizure severity and improved QOL outcomes. There was limited evidence regarding the use of VNS to treat patients with other genetic etiologies of epilepsy, such as mitochondrial disease, Rett syndrome, Doose syndrome, Landau-Kleffner syndrome, Aicardi syndrome, Angelman syndrome, ring chromosome 20 syndrome, and lissencephaly; variable responses were reported in a limited number of cases.

CONCLUSIONS
The authors conducted a systematic review of VNS outcomes in children with genetic etiologies of DRE. Among the most studied conditions, patients with TSC had substantial seizure reduction and improvements in QOL, whereas those with DS had less robust seizure reduction. Increased testing, diagnosis, and long-term follow-up studies are necessary to better characterize VNS response in these children.
Adaptation of stochastic model of economic cycles to empiric data
Authors: Karmalita Viacheslav 
Published: March 2022

This paper deals with adaptation of the stochastic model of the economic cycle, represented by the values of the gross product. Establishing the statistical equivalence of the Yule series to discrete samples of income oscillations made it possible to determine analytical expressions between the coefficients of the Yule model and the parameters of economic cycle. This, the adaptation of the cycle model to empirical data is reduced to the linear problem of estimating the Yule model factors. The peculiarity of solution to this problem ensures the presence of an optimal discretization of the income function in the form of four samples for the cycle period. It is shown that with such discretization, the highest accuracy of calculated parameter estimates is ensured, that is, the efficiency of the estimates is obtained.
The proposed procedure for adapting the cycle models considers the features of the economic data and provides: 1) recovery of the income function from values of the gross product estimates; 2) extraction of values of a cycle under interest from the recovered data; 3) determination of the time interval of cycle pseudo-stationarity; 4) parameter estimation of the cycle model; 5) accuracy analysis of parameter estimates. The procedure is formally (mathematically) described from the empirical values of the gross product to getting estimates of cycle parameters. It is applicable for econometric problems of estimating the parameters of systems described by ordinary differential and difference equations of the second order.
PERFIL DAS AÇÕES DE EXTENSÃO DA UNIVERSIDADE FEDERAL DO CEARÁ
Authors: Gomes de Alcântara Filho José Airton , De Araujo Cavalcante Sueli Maria , Fonteles Rios Nara Raquel , Da Silva Braga Marques Pauliane Venessa , Costa Soares Veruska 
Published: March 2022

O estudo objetiva traçar o perfil das ações de extensão desenvolvidas na Universidade Federal do Ceará (UFC). Aborda a extensão universitária como um eixo indissociável do ensino e da pesquisa, essencial para o cumprimento da missão da Universidade Pública. Trata-se de uma pesquisa descritiva, quantitativa e documental, na qual foram analisadas planilhas publicadas pela Pró-Reitoria de Extensão, das quais foram extraídas informações sobre as ações de extensão no que tange às modalidades, áreas temáticas e campi de atuação. Os resultados obtidos indicaram a predominância da modalidade projeto, maior número de ações de extensão no Campus Porangabuçu e identificação da área temática Saúde como a mais presente nas ações de extensão da Universidade. Os resultados auferidos foram reproduzidos em tabelas e poderão ser utilizados pela gestão para guiar o planejamento das novas ações de extensão da UFC.
Aspectos bioéticos da morte encefálica frente à diferentes religiões
Authors: Mosini Amanda Cristina , Pires Jaime Moreira , Susemihl Maria Alice , Calió Michele  Longoni , Pinto Lécio Figueira 
Published: March 2022

O termo Morte Encefálica (ME) foi definido na década de 60, com rápida notoriedade e a ocorrência de controvérsias e discussões bioéticas devido às diferenças culturais e religiosas. Esse trabalho buscou discutir aspectos bioéticos da determinação de ME nas diferentes religiões. Trata-se de uma revisão de literatura na base PubMed, utilizando os descritores: “Brain death”, “Faith” e “Bioethics”, publicados nos últimos 10 anos. Dos 36 artigos encontrados, 13 preenchiam os critérios de inclusão. Observou-se variabilidade nos critérios de determinação de ME entre países e religiões. A religião católica tem mais clareza e consenso na aceitação, enquanto em outras religiões não é aceito ou não existe consenso na interpretação e aceitação. As diferenças nos critérios de ME entre países e aceitação entre religiões é complexo. Os quatro princípios da bioética (Autonomia, Beneficência, Não maleficência e Justiça) devem ser entendidos e aplicados em cada contexto cultural e religioso.
Ácido Ascórbico como adjuvante no tratamento de anemia em pacientes com Doença Renal Crônica sob Hemodiálise: revisão integrativa da literatura
Authors: Azevedo Kleber Luiz da Fonseca , Souza Eudes Euler de Lucena , Andrade Micássio Fernandes 
Published: March 2022

Objetivo: investigar na literatura as evidências científicas sobre os efeitos do Ácido Ascórbico em desfechos bioquímicos tais como hemoglobina, ferritina e saturação de transferrina em pacientes com doença renal crônica submetidos à terapia renal substitutiva. Métodos: Trata-se de um estudo de Revisão Integrativa da Literatura com abordagem qualitativa. Utilizaram-se as bases de dados; Literatura Latino-Americana em Ciências da Saúde (LILACS), Medical Literature and Retrieval System on Line (Medline), Excerpta Médica dataBASE (EMBASE), Cochrane Library. Foram incluídos 11 estudos, apenas ensaios clínicos que utilizaram o ácido ascórbico em pacientes sob hemodiálise e analisaram seus efeitos. Resultados: Os achados corroboram para a eficácia do Ácido Ascórbico como adjuvante no tratamento da anemia em pacientes submetidos em tratamento de hemodiálise, uma vez que aumenta a hemoglobina sérica e reduz a necessidade da Eritropoetina Recombinante Humana. Alé disso, retratam a redução dos níveis de ferritina sérica e a elevação da saturação de transferrina, fato que eleva sua biodisponibilidade e ser útil na deficiência funcional de ferro. Conclusão: Embora os estudos sejam limitados pelo pequeno número de participantes, curta duração do seguimento após a intervenção e variabilidade de qualidade, o Ácido Ascórbico se apresenta como eficaz como coadjuvante no controle da anemia. Estudos mais prolongados são necessários para confirmar estes resultados, relatar eventos adversos e determinar o impacto nos desfechos a longo prazo.
Intermittent Short-Duration Re-oxygenation Attenuates Cardiac Changes in Response to Hypoxia: Histological, Ultrastructural and Oxidant/Antioxidant Parameters
Authors: Shati Ayed A. , Zaki Mohamed Samir A. , Alqahtani Youssef A. , Haidara Mohamed A. , Alshehri Mohammed A. , Dawood Amal F. , Eid Refaat A. 
Published: March 2022

Context: Intermittent short-duration re-oxygenation attenuates cardiac changes in response to hypoxia.Objective: To see if intermittent short-duration re-oxygenation may protect the heart muscle from hypoxia damage.Materials and Methods: Eighteen albino rats were used to carry out the study. Rats divided into: (normoxia); rats exposed to room air as a control, second (hypoxic) group; rats subjected to a pressure of 405 mmHg in a hypobaric chamber to simulate hypoxia at 5,000 m, and third (intermittent short-duration re-oxygenation); rats exposed to room air three times per day. Experiments were all 14 days long.Results: Hypoxia enhanced the oxidative stress biomarker malondialdehyde while lowering the antioxidant superoxide dismutase . The levels of tumour necrosis factor (TNF-α) and interleukin-6 (IL-6) in the myocardium were elevated in hypoxic hearts. The hypoxic rats’ cardiac myofibrils showed disarray of muscle fibres, vacuolation of the sarcoplasm, pyknosis of the nucleus, and expansion of intercellular gaps on histological examination. In addition, cardiomyocytes showed degenerative defects in ventricular myocardial cells on ultrastructural analysis. Myofibril thinning and degenerative mitochondrial changes affected intercalated discs with fascia adherent, desmosomes, and gap junction. Intermittent short-duration re-oxygenation improve cardiac histological, ultrastructural and oxidant/antioxidant parameters changes during hypoxia.Conclusion: Hypoxia showed a substantial impact on myocardial architecture, as well as increased oxidative stress and pro-inflammatory cytokines. Intermittent short-duration re-oxygenation significantly decreases hypoxia-induced cardiac changes.
Achieving Partial Nitrification-Anammox Process Dependent on Microalgal-Bacterial Consortia in a Photosequencing Batch Reactor
Authors: Yang Miao , Xie Kun-Peng , Ma Chi , Yu Si-Hui , Ma Jing-Yi , Yu Ze-Quan , Chen Xi , Gong Zheng 
Published: March 2022

Partial nitrification coupled with anammox (PN/A) process is an energy-efficient approach for nitrogen removal from low C/N wastewater. In this study, PN/A was achieved with optimal oxygen supply from a green microalga,Chlorella sorokiniana. The PN process was first initiated within 35 days, and the following algae-intensified PN then reached the steady state within the next 32 days. The dissolved oxygen (DO) concentration was gradually maintained at 0.6 mg L−1viaadjusting the photoperiod to 6-h light/18-h dark cycles, when the accumulation ratio of NO2−-N and the removal ratio of NH4+-N were both more than 90%. The nitrogen removal capability of anammox was acclimatedviaelevating the individual effluent NH4+-N and NO2−-N levels from 100 to 200, to 300 mg L−1. After acclimation, the removal rates of NH4+-N and total nitrogen (TN) reached more than 70 and 80%, respectively, and almost all the NO2−-N was removed. Then, the algae-intensified PN/A, algammox biofilm system, was successfully started up. When the NH4+-N level increased from 100 to 300 mg L−1, the TN removal varied between 78 and 82%. In the photosequencing bioreactor,C. sorokiniana, ammonia-oxidizing bacteria (AOB), and anammox coexisted with an illumination of 200 μmol m−2s−1and a 6-h light/18-h dark cycles. The DO levels ranged between 0.4 and 0.5 mg L−1. In addition, the microbial community analysis by Illumina MiSeq sequencing showed that the dominant functional bacteria in the algae-intensified PN/A reactors includedNitrosomonas(AOB) andCandidatus Brocadia(anammox), whileNitrospiraandNitrobacter(nitrite oxidizing bacteria), together withDenitratisoma(denitrifier) were largely inhibited. Further studies are required to optimize the microalgal–bacterial consortia system to achieve superior nitrogen removal rates under controllable conditions.