bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does motor functioning mediate the relationship between executive functions and psychological well-being of atypically developing older adults?
Authors: Fastame Maria Chiara , Mulas Ilaria , Putzu Valeria , Asoni Gesuina , Viale Daniela , Mameli Irene , Pau Massimiliano 
Published: January 2022

AbstractThe contribution of motor efficiency to the maintenance of psychological well-being in cognitively impaired older individuals is still insufficiently examined. This investigation primarily intended to evaluate whether muscular strength mediates the relationship between different facets of psychological well-being (i.e., personal satisfaction, emotional competence, coping), negative mood, and central executive efficiency through the Clock-Drawing, Trail-Making (Part A), and verbal fluency tests. Furthermore, the impact of cognitive decline on self-reported psychological well-being and depression was explored, using the handgrip strength (HGS) measure as a covariate. One hundred and nineteen older participants, 44 males and 75 females, aged 63 years and older (Mage = 77.7 years, SD = 5.6 years), completed a battery of tests assessing executive functions, HGS, depression, and psychological well-being. Significant low to moderate associations were found between distinct executive functions, HGS, psychological well-being, and depression. In addition, personal satisfaction did not correlate with any measure of executive functions, the clock-drawing score was associated only with coping index, and self-reported depression correlated only with the Trail-Making Test score. Moreover, a series of mediation analyses documented that executive functions (primarily assessing verbal fluency and motor speed) and HGS explained approximately 20–46% of the variance in perceived psychological well-being and depression. Finally, more cognitively impaired participants reported worse total psychological well-being, emotional competence, and coping. In conclusion, motor proficiency mediates the relationship between selective measures of executive functions and perceived psychological well-being and depression in cognitively impaired individuals.
Multistability and Derrida’s Différance: Investigating the Relations Between Postphenomenology and Stiegler’s General Organology
Authors: Pavanini Marco 
Published: January 2022

AbstractIn this paper, in the first place, I aim to enquire into Bernard Stiegler’s critical appropriation of his mentor Jacques Derrida’s notion of différance, emphasizing how Stiegler’s philosophy of technology stems from an original interpretation of the main tenets of deconstruction. From this perspective, I will investigate Stiegler’s definition of technology as tertiary retention, i.e., exosomatized, artificial memory interrelating with biological memory, testing its hermeneutic strengths as well as possible weaknesses. In the second place, I aim to contrast Stiegler’s understanding of technology with the concept of multistability brought forward by postphenomenological philosophies of technology such as those elaborated by Don Ihde and Peter-Paul Verbeek. This investigation will enable me to submit that Stiegler’s approach represents a peculiar and innovative way to conceive of technology. On the one hand, indeed, it does not seem to fall prey to the criticisms raised by postphenomenology against traditional philosophies of technology such as Martin Heidegger’s or Jacques Ellul’s, deemed to be overly deterministic, abstract and pessimistic in their understanding of technology. On the other, it retains important methodological precautions from deconstruction, thereby pointing at some possible blind spots of postphenomenology, especially concerning the vexed question of the empirical-transcendental divide, which Stiegler aims to develop beyond both Derrida’s and postphenomenology’s stances.
Active targeting via ligand-anchored pH-responsive strontium nanoparticles for efficient nucleic acid delivery into breast cancer cells
Authors: Bakhtiar Athirah , Liew Qing Xin , Ng Khuen Yen , Chowdhury Ezharul Hoque 
Published: January 2022

Abstract
Purpose
Gene therapy is a promising and novel therapeutic strategy for many mutated gene-associated diseases, including breast cancer. However, it poses significant biological drawbacks such as rapid clearance from the circulatory system and low cellular uptake of the exogenously delivered functional nucleic acids. The development of efficient and biocompatible carriers for genetic materials has been extensively explored in the literature, and the functionalization of nanoparticles (NPs) with cancer cell-recognizing ligands has become an attractive approach to promote tumor targetability and efficient cellular internalization via endocytosis.

Methods
This study introduced self-assembling targeting ligands, including transferrin and fibronectin with the ability to electrostatically interact with strontium nanoparticles (SNPs), and then analyzed their influence on size and zeta potential of the resultant hybrid SNPs, cellular uptake and expression efficiency of transgene-loaded hybrid NPs.

Results
Smaller ligand-coated SNPs (LCSNPs) remarkably increased gene transfection activity in both MCF-7 and 4T1 cells as well as nucleic acid localization into tumor tissues with improved tumor regression activity in a 4T1-tumor xenograft mouse model.

Conclusion
LCSNPs-mediated delivery of p53 gene and MAPK siRNA provided a proof-of-concept for the functionalized nanocarrier formulation in order to inhibit breast cancer cell growth.
SynergyFinder Plus: Toward Better Interpretation and Annotation of Drug Combination Screening Datasets
Authors: Zheng Shuyu , Wang Wenyu , Aldahdooh Jehad , Malyutina Alina , Shadbahr Tolou , Tanoli Ziaurrehman , Pessia Alberto , Tang Jing 
Published: January 2022

Abstract
Combinatorial therapies have been recently proposed to improve the efficacy of anticancer treatment. The SynergyFinder R package is a software used to analyze pre-clinical drug combination datasets. Here, we report the major updates to the SynergyFinder R package for improved interpretation and annotation of drug combination screening results. Unlike the existing implementations, the updated SynergyFinder R package includes five main innovations. 1) We extend the mathematical models to higher-order drug combination data analysis and implement dimension reduction techniques for visualizing the synergy landscape. 2) We provide a statistical analysis of drug combination synergy and sensitivity with confidence intervals and P values. 3) We incorporate a synergy barometer to harmonize multiple synergy scoring methods to provide a consensus metric for synergy. 4) We evaluate drug combination synergy and sensitivity to provide an unbiased interpretation of the clinical potential. 5) We enable fast annotation of drugs and cell lines, including their chemical and target information. These annotations will improve the interpretation of the mechanisms of action of drug combinations. To facilitate the use of the R package within the drug discovery community, we also provide a web server at www.synergyfinderplus.org as a user-friendly interface to enable a more flexible and versatile analysis of drug combination data.
Guidelines for postmortem examination of newborn dogs
Authors: Mila Hanna , Guerard Chloé , Raymond-Letron Isabelle 
Published: January 2022

Abstract
Neonatal mortality in puppies is a problem frequently encountered by dog breeders. Often, only postmortem examination allows diagnosis and implementation of measures to save the rest of the litter. This article presents the key steps of the postmortem examination, namely, autopsy, histopathology, bacteriology, molecular identification of pathogens, and coproscopy. Sampling, samples' conservation, and interpretation of the obtained results are presented as well as their relative importance for the final diagnosis. Finally, examples of the most frequent syndromes observed under postmortem examination in canine newborns, together with the results from a complementary analysis looking for infectious agents responsible for death, are discussed.
Hydromechanical Effects of Micro‐Organisms on Fine‐Grained Sediments During Early Burial
Authors: Mills N. Tanner , Reece Julia S. , Tice Michael M. , Sylvan Jason B. 
Published: January 2022

AbstractMicro‐organisms are known to change fluid flow and permeability processes in subsurface environments, but this has only been demonstrated for coarse‐grained sediments and fractures. For fine‐grained sediments (mudstones), little is known about the effects of micro‐organisms on hydromechanical properties. Here, we investigated the influence of micro‐organisms on the porosity, permeability, and compressibility of fine‐grained sediments. We performed resedimentation experiments with and without micro‐organisms added to two reconstituted, fine‐grained sediment samples. These sediments were collected from the Ursa and Brazos‐Trinity Basins in the Gulf of Mexico during Integrated Ocean Drilling Program Expedition 308. Micro‐organisms caused a systematic, yet small increase in compression index for both sediments. Changes to permeability caused by micro‐organisms, while relatively minor, were greater for the Ursa sediment than the Brazos‐Trinity sediment. Additionally, the effect of micro‐organisms on permeability is greater at higher porosities and lower vertical effective stresses. Differences in permeability behavior between the two sediments are likely due to differences in sediment properties and nutrients for microbial growth. We therefore suggest that the effectiveness of micro‐organisms at altering fluid flow in fine‐grained sediments is dependent on burial depth (porosity as a function of vertical effective stress) and the grain size, pore and pore throat size, and specific surface area of a sediment. Characterizing the effects of micro‐organisms on the hydromechanical properties of fine‐grained sediments can further our understanding of the controls on pore pressure near the sediment–water interface in marine environments and aid in bioclogging practices around contaminated sites in terrestrial environments.
Three Mw ≥ 4.7 Earthquakes Within the Changning (China) Shale Gas Field Ruptured Shallow Faults Intersecting With Hydraulic Fracturing Wells
Authors: Wang Shuai , Jiang Guoyan , Lei Xinglin , Barbour Andrew J. , Tan Xibin , Xu Caijun , Xu Xiwei 
Published: January 2022

AbstractFrom 2017 to 2019, three destructive earthquakes (27 January 2017 Mw 4.7, 16 December 2018 Mw 5.2, and 3 January 2019 Mw 4.8) occurred in the Changning shale gas field in the southwest Sichuan Basin, China. Previous seismological studies attributed these events to hydraulic fracturing (HF), but were unable to identify the causative seismogenic faults and their slip behaviors. Here, we use Sentinel‐1 synthetic aperture radar data to measure surface deformation triggered by the three events and conduct geodetic inversions to characterize their rupture models. The resulting coseismic interferograms show prominent surface deformation with the maximum line‐of‐sight displacements of up to 4 cm. The inversion results show that all three earthquakes mainly ruptured sedimentary formations above the shale gas bed, in the upper 3 km of the crust, with slip magnitudes ranging from 8.5 to 15 cm, and stress drops ranging from ∼1.8 to ∼3.3 MPa. Their source faults intersect with horizontal HF wells, but do not root in the crystalline basement. Combined with the reported difficulty of increasing HF operation pressures prior to the three events, we argue that they were most likely induced by direct injection of pressurized fluids into the fault zones. Crustal deformation patterns inferred from regional topography and GPS velocities highlight that the Changning field is located within a triple junction region near the southeastern margin of the Tibetan Plateau with large deformation gradients; such conditions are not only favorable to the development of critically stressed faults, but also facilitate the occurrence of at least moderate magnitude earthquakes.
Ocean Productivity in the Gulf of Cadiz Over the Last 50 kyr
Authors: Penaud A. , Eynaud F. , Etourneau J. , Bonnin J. , de Vernal A. , Zaragosi S. , Kim J.‐H. , Kang S. , Gal J.‐K. , Oliveira D. , Waelbroeck C. 
Published: January 2022

AbstractReconstructions of ocean primary productivity (PP) help to explain past and present biogeochemical cycles and climate changes in the oceans. We document PP variations over the last 50 kyr in a currently oligotrophic subtropical region, the Gulf of Cadiz. Data combine refined results from previous investigations on dinocyst assemblages, alkenones, and stable isotopes (18O, 13C) in planktonic (Globigerina bulloides) and endobenthic (Uvigerina mediterranea) foraminifera from cores MD04‐2805 CQ and MD99‐2339, with new isotopic measurements on epibenthic (Cibicides pachyderma‐Cibicidoides wuellerstorfi) foraminifera and dinocyst‐based estimates of PP using the new n = 1,968 modern database. We constrain PP variations and export production by integrating qualitative information from bioindicators with dinocyst‐based quantitative reconstructions such as PP and seasonal sea surface temperature and information about remineralization from the benthic Δδ13C (difference between epibenthic and endobenthic foraminiferal δ13C signatures). This study also includes new information on alkenone‐based SST and total organic carbon which provides insights into the relationship between past regional hydrological activity and PP regime change. We show that PP, carbon export, and remineralization were generally high in the NE subtropical Atlantic Ocean during the last glacial period and that the Last Glacial Maximum (LGM) had lower Δδ13C than the Heinrich Stadials with sustained high PP, likely allowing enhanced carbon sequestration. We link these PP periods to the dynamics of upwelling, active almost year‐round during sadials, but restricted to spring‐summer during interstadials and LGM, like today. During interstadials, nutrient advection through freshwater inputs during autumn‐winter needs also to be considered to fully understand PP regimes.
Genetic common variants associated with cerebellar volume and their overlap with mental disorders: a study on 33,265 individuals from the UK-Biobank
Authors: Chambers Tom , Escott-Price Valentina , Legge Sophie , Baker Emily , Singh Krish D. , Walters James T. R. , Caseras Xavier , Anney Richard J. L. 
Published: January 2022

AbstractInterest in the cerebellum is expanding given evidence of its contributions to cognition and emotion, and dysfunction in various psychopathologies. However, research into its genetic architecture and shared influences with liability for mental disorders is lacking. We conducted a genome-wide association study (GWAS) of total cerebellar volume and underlying cerebellar lobe volumes in 33,265 UK-Biobank participants. Total cerebellar volume was heritable (h2SNP = 50.6%), showing moderate genetic homogeneity across lobes (h2SNP from 35.4% to 57.1%; mean genetic correlation between lobes rg ≈ 0.44). We identified 33 GWAS signals associated with total cerebellar volume, of which 6 are known to alter protein-coding gene structure, while a further five mapped to genomic regions known to alter cerebellar tissue gene expression. Use of summary data-based Mendelian randomisation further prioritised genes whose change in expression appears to mediate the SNP-trait association. In total, we highlight 21 unique genes of greatest interest for follow-up analyses. Using LD-regression, we report significant genetic correlations between total cerebellar volume and brainstem, pallidum and thalamus volumes. While the same approach did not result in significant correlations with psychiatric phenotypes, we report enrichment of schizophrenia, bipolar disorder and autism spectrum disorder associated signals within total cerebellar GWAS results via conditional and conjunctional-FDR analysis. Via these methods and GWAS catalogue, we identify which of our cerebellar genomic regions also associate with psychiatric traits. Our results provide important insights into the common allele architecture of cerebellar volume and its overlap with other brain volumes and psychiatric phenotypes.
Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals
Authors: Hou Siyuan , Li Zongcheng , Dong Ji , Gao Yun , Chang Zhilin , Ding Xiaochen , Li Shuaili , Li Yunqiao , Zeng Yang , Xin Qian , Wang Baihan , Ni Yanli , Ning Xiaowei , Hu Yuqiong , Fan Xiaoying , Hou Yu , Li Xianlong , Wen Lu , Zhou Bin , Liu Bing , Tang Fuchou , Lan Yu 
Published: January 2022

AbstractArteriogenesis rather than unspecialized capillary expansion is critical for restoring effective circulation to compromised tissues in patients. Deciphering the origin and specification of arterial endothelial cells during embryonic development will shed light on the understanding of adult arteriogenesis. However, during early embryonic angiogenesis, the process of endothelial diversification and molecular events underlying arteriovenous fate settling remain largely unresolved in mammals. Here, we constructed the single-cell transcriptomic landscape of vascular endothelial cells (VECs) during the time window for the occurrence of key vasculogenic and angiogenic events in both mouse and human embryos. We uncovered two distinct arterial VEC types, the major artery VECs and arterial plexus VECs, and unexpectedly divergent arteriovenous characteristics among VECs that are located in morphologically undistinguishable vascular plexus intra-embryonically. Using computational prediction and further lineage tracing of venous-featured VECs with a newly developed Nr2f2CrexER mouse model and a dual recombinase-mediated intersectional genetic approach, we revealed early and widespread arterialization from the capillaries with considerable venous characteristics. Altogether, our findings provide unprecedented and comprehensive details of endothelial heterogeneity and lineage relationships at early angiogenesis stages, and establish a new model regarding the arteriogenesis behaviors of early intra-embryonic vasculatures.
Parallel functional assessment of m6A sites in human endodermal differentiation with base editor screens
Authors: Cheng Weisheng , Liu Fang , Ren Zhijun , Chen Wenfang , Chen Yaxin , Liu Tianwei , Ma Yixin , Cao Nan , Wang Jinkai 
Published: January 2022

AbstractN6-methyladenosine (m6A) plays important role in lineage specifications of embryonic stem cells. However, it is still difficult to systematically dissect the specific m6A sites that are essential for early lineage differentiation. Here, we develop an adenine base editor-based strategy to systematically identify functional m6A sites that control lineage decisions of human embryonic stem cells. We design 7999 sgRNAs targeting 6048 m6A sites to screen for m6A sites that act as either boosters or barriers to definitive endoderm specification of human embryonic stem cells. We identify 78 sgRNAs enriched in the non-definitive endoderm cells and 137 sgRNAs enriched in the definitive endoderm cells. We successfully validate two definitive endoderm promoting m6A sites on SOX2 and SDHAF1 as well as a definitive endoderm inhibiting m6A site on ADM. Our study provides a functional screening of m6A sites and paves the way for functional studies of m6A at individual m6A site level.
The shape of memory in temporal networks
Authors: Williams Oliver E. , Lacasa Lucas , Millán Ana P. , Latora Vito 
Published: January 2022

AbstractHow to best define, detect and characterize network memory, i.e. the dependence of a network’s structure on its past, is currently a matter of debate. Here we show that the memory of a temporal network is inherently multidimensional, and we introduce a mathematical framework for defining and efficiently estimating the microscopic shape of memory, which characterises how the activity of each link intertwines with the activities of all other links. We validate our methodology on a range of synthetic models, and we then study the memory shape of real-world temporal networks spanning social, technological and biological systems, finding that these networks display heterogeneous memory shapes. In particular, online and offline social networks are markedly different, with the latter showing richer memory and memory scales. Our theory also elucidates the phenomenon of emergent virtual loops and provides a novel methodology for exploring the dynamically rich structure of complex systems.
Heterospin frustration in a metal-fullerene-bonded semiconductive antiferromagnet
Authors: Shen Yongbing , Cui Mengxing , Takaishi Shinya , Kawasoko Hideyuki , Sugimoto Kunihisa , Tsumuraya Takao , Otsuka Akihiro , Kwon Eunsang , Yoshida Takefumi , Hoshino Norihisa , Kawachi Kazuhiko , Kasama Yasuhiko , Akutagawa Tomoyuki , Fukumura Tomoteru , Yamashita Masahiro 
Published: January 2022

AbstractLithium-ion-encapsulated fullerenes (Li+@C60) are 3D superatoms with rich oxidative states. Here we show a conductive and magnetically frustrated metal–fullerene-bonded framework {[Cu4(Li@C60)(L)(py)4](NTf2)(hexane)}n (1) (L = 1,2,4,5-tetrakis(methanesulfonamido)benzene, py = pyridine, NTf2− = bis(trifluoromethane)sulfonamide anion) prepared from redox-active dinuclear metal complex Cu2(L)(py)4 and lithium-ion-encapsulated fullerene salt (Li+@C60)(NTf2−). Electron donor Cu2(L)(py)2 bonds to acceptor Li+@C60 via eight Cu‒C bonds. Cu–C bond formation stems from spontaneous charge transfer (CT) between Cu2(L)(py)4 and (Li+@C60)(NTf2−) by removing the two-terminal py molecules, yielding triplet ground state [Cu2(L)(py)2]+(Li+@C60•−), evidenced by absorption and electron paramagnetic resonance (EPR) spectra, magnetic properties and quantum chemical calculations. Moreover, Li+@C60•− radicals (S = ½) and Cu2+ ions (S = ½) interact antiferromagnetically in triangular spin lattices in the absence of long-range magnetic ordering to 1.8 K. The low-temperature heat capacity indicated that compound 1 is a potential candidate for an S = ½ quantum spin liquid (QSL).
Unraveling of cocatalysts photodeposited selectively on facets of BiVO4 to boost solar water splitting
Authors: Qi Yu , Zhang Jiangwei , Kong Yuan , Zhao Yue , Chen Shanshan , Li Deng , Liu Wei , Chen Yifan , Xie Tengfeng , Cui Junyan , Li Can , Domen Kazunari , Zhang Fuxiang 
Published: January 2022

AbstractBismuth vanadate (BiVO4) has been widely investigated as a photocatalyst or photoanode for solar water splitting, but its activity is hindered by inefficient cocatalysts and limited understanding of the underlying mechanism. Here we demonstrate significantly enhanced water oxidation on the particulate BiVO4 photocatalyst via in situ facet-selective photodeposition of dual-cocatalysts that exist separately as metallic Ir nanoparticles and nanocomposite of FeOOH and CoOOH (denoted as FeCoOx), as revealed by advanced techniques. The mechanism of water oxidation promoted by the dual-cocatalysts is experimentally and theoretically unraveled, and mainly ascribed to the synergistic effect of the spatially separated dual-cocatalysts (Ir, FeCoOx) on both interface charge separation and surface catalysis. Combined with the H2-evolving photocatalysts, we finally construct a Z-scheme overall water splitting system using [Fe(CN)6]3−/4− as the redox mediator, whose apparent quantum efficiency at 420 nm and solar-to-hydrogen conversion efficiency are optimized to be 12.3% and 0.6%, respectively.