bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimicrobial use in lactating sows, piglets, nursery, and grower-finisher pigs on swine farms in Ontario, Canada during 2017 and 2018
Authors: Bosman Angelina L. , Deckert Anne E. , Carson Carolee A. , Poljak Zvonimir , Reid-Smith Richard J. , McEwen Scott A. 
Published: April 2022

Abstract
Background
Data on antimicrobial use (AMU) in pig production are needed for the development of good antimicrobial stewardship practices to reduce the risk of antimicrobial resistance in bacteria that can cause illness in animals and humans. In Canada, there is a lack of quantitative data on AMU in the farrowing and nursery stages of pig production. This study aimed to determine which antimicrobial active ingredients are currently used in farrowing, nursery, and grower-finisher herds in the province of Ontario, Canada, and to quantify AMU using various metrics. We collected data on herd demographics, biosecurity, health status, and AMU during one production cycle from 25 farrowing and 25 nursery herds in Ontario, between May 2017 and April 2018, and obtained data from 23 Ontario grower-finisher herds during the same time frame from the Public Health Agency’s Canadian Integrated Program for Antimicrobial Resistance Surveillance. We applied frequency measures, and weight-, and dose-based metrics to the data.

Results
In all pigs, the highest quantity of AMU was administered in-feed. By all routes of administration and compared to other production stages, nursery pigs used more antimicrobials in mg/kg biomass and the number of Canadian defined daily doses per 1000 pig-days (doseCA rate), while grower-finisher pigs used more antimicrobials in total kilograms and the number of Canadian defined daily doses per pig. In suckling pigs in some herds, there was routine disease prevention use of ceftiofur, an antimicrobial active ingredient categorized as very highly important in human medicine by Health Canada. The top antimicrobial used in each stage of pig production often varied by the metric used. There was producer-reported growth promotion use of antimicrobials in suckling and grower-finisher feed.

Conclusions
The results of this study provide a current picture of AMU in pigs in Ontario and can be used as a basis for further research on AMU in farrowing and nursery herds in Canada. Our findings confirm that it would be useful to include farrowing and nursery herds in routine AMU surveillance in Canada. A future analysis using data from this project will examine factors that affect the quantity of AMU.
Effects of antirejection therapies for early subclinical acute rejection in renal transplant protocol biopsies
Authors: Sakurabayashi Kei , Muramatsu Masaki , Itabashi Yoshihiro , Oguchi Hideyo , Kawamura Takeshi , Hamasaki Yuko , Mikami Tetsuo , Tochigi Naobumi , Shishido Seiichiro , Sakai Ken 
Published: April 2022

Abstract
Background
Although recently strengthened immunosuppression protocols have decreased the incidence of clinical acute rejection of renal transplants, subclinical acute rejection and borderline changes remain problematic. This study was performed to evaluate the effects of antirejection therapies for early subclinical acute rejection and borderline changes.

Methods
In total, 269 renal transplant patients who received 3-month and 1-year protocol biopsies after renal transplantation were enrolled this study and divided into those with normal findings (Group A) and those with ≥ borderline changes (Group B) according to the 3-month pathological results. Pathological changes, graft function, and graft survival were evaluated at 1 year.

Results
The 3-month protocol biopsy revealed normal findings in 166 patients (Group A) and borderline changes and subclinical acute rejection in 103 patients (Group B). In Group A, 65.1% (n = 108) of the patients maintained normal findings at 1 year, while 30.1% (n = 50) deteriorated to ≥ borderline changes. In Group B, 52.4% (n = 54) of patients improved to normal. Among patients with subclinical acute rejection, 25.0% (n = 5) maintained subclinical acute rejection at 1 year despite antirejection therapy. The mean estimated glomerular filtration rate decreased from 60.4 ± 24.5 to 58.3 ± 19.0 mL/min/1.73 m2 in Group A and from 57.2 ± 28.2 to 53.7 ± 20.3 mL/min/1.73 m2 in Group B (p = 0.417). The 3-, 5-, and 7-year graft survival rates were 99.4%, 99.4%, and 97.6% in Group A and 100.0%, 98.6%, and 98.6% in Group B, respectively (p = 0.709).

Conclusions
Subclinical acute rejection is likely to recur. However, intervention for subclinical acute rejection in the early period after transplantation may help to prevent subsequent histological changes.
An analysis of privacy preservation in electric vehicle charging
Authors: Unterweger Andreas , Knirsch Fabian , Engel Dominik , Musikhina Daria , Alyousef Ammar , de Meer Hermann 
Published: April 2022

AbstractElectric vehicles (EVs) are gaining widespread adoption, which requires expanding the charging infrastructure. This infrastructure is part of a complex ecosystem that consists of multiple entities interacting with each other and exchanging (often personal) user data. Such a heterogeneous system with multiple participants exchanging personal data poses severe privacy risks to users. State-of-the-art literature insufficiently covers privacy aspects of charging ecosystem use cases. In this paper, a profound analysis of this ecosystem with respect to privacy is provided: First, the EV charging ecosystem and its entities are defined. Second, high-level use cases for EV charging identified in literature are analyzed and used for defining data flows within the charging ecosystem. Third, the identified use cases are compared in terms of privacy guarantees and adherence to standards. Fourth, representative implementations of these use cases are evaluated, i.e., all actors and (unintended) data flows are described and potential privacy threats are identified and visualized. It is found that privacy is not sufficiently covered by standards and implementations of EV charging use cases from literature. Furthermore, recommendations and future directions for protecting user privacy in the EV charging ecosystem are derived. In summary, stricter adherence to standards and privacy by design are suggested.
Barriers Faced by Returning Migrant Children in Vietnam: The Case of the Mekong Delta Region
Authors: Iwai Misaki 
Published: April 2022

Abstract
In recent years, there has been a noticeable presence of children known as “unrecognized” in the Vietnamese media. These children are the offspring of Vietnamese women married to Korean or Taiwanese men who have returned to Vietnam following divorce or separation. This article focuses on these marginalized mixed children and explores the diversity of their backgrounds and experiences after returning home. It establishes how various barriers faced by mothers have discouraged them from securing their children's citizenship, resulting in the “unrecognized” status of the latter. As established in this article, this leads to both structural and social barriers that include isolation and limited access to education.
Facile Preparation of Porous Low Density Polyethylene Monolith for Efficient Oil/Water Separation
Authors: Wang Qidong , Li Bin , Liu Qingshan , Qi Yanxia , Zhao Mingxing , Wang Hua , Asoh Taka-Aki , Uyama Hiroshi 
Published: April 2022

Abstract
A promising porous low-density polyethylene (LDPE) monolith has been successfully prepared for the first time via a facile thermally induced phase separation (TIPS) method, followed by vacuum drying. The obtained LDPE monolith, with excellent hydrophobicity, shows highly efficient and selective adsorption of oil from oil/water mixtures including oil-in-water emulsion.
Gut Leakage and Cardiac Biomarkers after Prolonged Strenuous Exercise
Authors: AUNE SUSANNE KRISTINE , BONNEVIE-SVENDSEN MARTIN , NYBORG CHRISTOFFER , TRØSEID MARIUS , SELJEFLOT INGEBJØRG , HISDAL JONNY , HELSETH RAGNHILD 
Published: April 2022

ABSTRACT

Purpose
Transient increase in the cardiac biomarkers troponin T (cTnT) and NT-proBNP are observed during strenuous exercise, even in healthy athletes. Gut leakage, the translocation of bacterial lipopolysaccharide (LPS) into the circulation, is associated with atherosclerosis and cardiovascular disease but has also been reported after prolonged endurance exercise. We aimed to explore the link between exercise-induced gut leakage and cardiac biomarker release.

Methods
Participants in Norseman Xtreme Triathlon (Norseman) were included (n = 44, age 43 ± 9 yr, 9 [21%] women). Blood samples were taken before and immediately after the race for the determination of biomarkers. cTnT and NT-proBNP were measured by conventional methods. Gut leakage marker LPS was measured by the kinetic, chromogenic limulus amebocyte lysate assay method, whereas LPS-binding protein (LBP), soluble cluster of differentiation 14 (sCD14), and intestinal injury marker intestinal fatty acid–binding protein (I-FABP) were measured by enzyme-linked immunosorbent assay.

Results
Median (25, 75 percentiles) finish time was 14 h 33 min (13 h 42 min, 15 h 29 min). TnT and NT-proBNP increased significantly to 38 ng·L−1 (27, 56) and 495 ng·L−1 (310, 828) after the race (P < 0.001, both). LBP and sCD14 also increased significantly (P < 0.001, both), as did I-FABP (P = 0.003), whereas LPS remained unchanged (P = 0.13). No significant correlations between changes in gut leakage markers and changes in cardiac biomarkers were observed after adjusting for multiple testing.

Conclusions
Cardiac and gut leakage biomarkers increased after Norseman Xtreme triathlon. However, changes in these biomarkers were not intercorrelated, suggesting that the exercise-induced increase in cardiac and gut leakage biomarkers occurs independently of each other.
Adolescents with Sport-Related Concussion Who Adhere to Aerobic Exercise Prescriptions Recover Faster
Authors: CHIZUK HALEY M. , WILLER BARRY S. , CUNNINGHAM ADAM , BEZHERANO ITAI , STOREY EILEEN , MASTER CHRISTINA , MANNIX REBEKAH , WIEBE DOUG J. , GRADY MATTHEW F. , MEEHAN WILLIAM P. , LEDDY JOHN J. , HAIDER MOHAMMAD N. 
Published: April 2022

ABSTRACT

Purpose
There is growing evidence that subsymptom threshold aerobic exercise speeds recovery from sport-related concussion (SRC). It is not known whether there is a direct relationship between adherence to a personalized exercise prescription and recovery or if initial symptom burden affects adherence to the prescription.

Methods
This study was a planned secondary analysis of one arm of a randomized controlled trial. Male and female adolescent athletes (age 13–18 yr) presenting within 10 d of SRC were given aerobic exercise prescriptions based on their heart rate threshold at the point of exercise intolerance on a graded treadmill test. Adherence was determined objectively with HR monitors and compared against time to recovery. Participants who completed at least two-thirds of their aerobic exercise prescription were considered to be adherent.

Results
Sixty-one percent of adolescents met the adherence criterion. Those who were adherent were more symptomatic and were more exercise intolerant at their initial visit, yet they recovered faster than those who were not adherent (median recovery time, 12 (interquartile range, 9–22) d vs 21.5 (interquartile range, 13–29.8) d; P = 0.016). On linear regression, adherence during week 1 was inversely related to recovery time (β = −0.002 (−0.003, 0.0), P = 0.046) and to initial exercise tolerance (β = −0.886 (−1.385, −0.387), P < 0.001), but not to initial symptom severity (β = 0.545 (−0.232, 1.323), P = 0.146). No adverse events or near misses were reported.

Conclusions
Adherence to individualized subsymptom threshold aerobic exercise within the first week of evaluation is associated with faster recovery from SRC. The data suggest that initial degree of exercise intolerance, but not initial symptom severity, affects adherence to aerobic exercise prescribed to adolescents within 10 d of SRC.
Prevalence of responsible research practices among academics in The Netherlands
Authors: Gopalakrishna Gowri , Wicherts Jelte M. , Vink Gerko , Stoop Ineke , van den Akker Olmo R. , ter Riet Gerben , Bouter Lex M. 
Published: April 2022

Background:Traditionally, research integrity studies have focused on research misbehaviors and their explanations. Over time, attention has shifted towards preventing questionable research practices and promoting responsible ones. However, data on the prevalence of responsible research practices, especially open methods, open codes and open data and their underlying associative factors, remains scarce.Methods:We conducted a web-based anonymized questionnaire, targeting all academic researchers working at or affiliated to a university or university medical center in The Netherlands, to investigate the prevalence and potential explanatory factors of 11 responsible research practices.Results:A total of 6,813 academics completed the survey, the results of which show that prevalence of responsible practices differs substantially across disciplines and ranks, with 99 percent avoiding plagiarism in their work but less than 50 percent pre-registering a research protocol. Arts and humanities scholars as well as PhD candidates and junior researchers engaged less often in responsible research practices. Publication pressure negatively affected responsible practices, while mentoring, scientific norms subscription and funding pressure stimulated them.Conclusions:Understanding the prevalence of responsible research practices across disciplines and ranks, as well as their associated explanatory factors, can help to systematically address disciplinary- and academic rank-specific obstacles, and thereby facilitate responsible conduct of research.
Case Report: Godoy & Godoy method of cervical lymphatic therapy – indirect evaluation of the effect of the duration of stimulation on ocular edema
Authors: Pereira de Godoy Jose Maria , Pereira de Godoy Henrique Jose , Pereira de Godoy Ana Carolina , Guerreiro Godoy Maria de Fatima 
Published: April 2022

The aim of the present study is to report the indirect evaluation of cervical stimulation considering the effect of the duration of the stimulus on the control of intraocular pressure in a patient with bilateral glaucoma with important ocular edema. A 47-year-old woman reported the onset of pain and bilateral tearing in the eyes at 35 years of age and was diagnosed with glaucoma. The patient began clinical treatment, but intraocular pressure remained 35 to 40 mmHg even with the use of four eye medications in the form of drops. The patient reported that her vision was always blurred despite the use of the eyedrops. The patient was submitted to the Godoy & Godoy method of cervical lymphatic therapy to reduce the edema. The ophthalmologist measured her intraocular pressure every two and three days. We found that the pressure was maintained below 20 mmHg when lymphatic therapy was performed every two days, but intraocular pressure increased and the vision became blurred when therapy was performed every three days. The Godoy & Godoy method of cervical lymphatic therapy constitutes a novel lymphatic system stimulation strategy that maintains its effect on intraocular pressure for approximately 48 hours, as demonstrated through an indirect evaluation.
Pre-grant Patent Disclosure and Analyst Forecast Accuracy
Authors: Beyhaghi Mehdi , Khashabi Pooyan , Mohammadi Ali 
Published: April 2022

We examine the relationship between pre-grant patent disclosure and analyst forecast accuracy. We take advantage of the passage of the American Inventor’s Protection Act (1999), which mandates the pre-grant public disclosure of all information in patent application documents within 18 months of the initial filings. We find that, on average, the pre-grant patent disclosure of corporate inventions significantly improves the accuracy of analyst forecasts about the patenting firm and this improvement is greater for firms with higher research and development intensity. Nevertheless, improvements in the accuracy of analysts’ forecasts are smaller when firms issue more original and scientifically broader patents. Also, this effect is weaker for firms in states without legal protection for trade secrets. This paper was accepted by Brian Bushee, accounting. Funding: Ali Mohammadi gratefully acknowledges support from the Danish Finance Institute. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.4420 .
Gatekeeping and the Use of Contested Practices in Creative Industries: The Case of Fur in Fashion
Authors: Godart Frédéric , Hsu Greta , Negro Giacomo 
Published: April 2022

In creative industries, a producer’s choice to use specific cultural practices is often driven by considerations of industry-specific notions of creativity and artistic vision. Creative producers claim autonomy over which practices are deemed desirable or legitimate, creating resistance to influences from outside the industry, such as from social movements. This study proposes that in such contexts, externally-driven change depends on the role of prominent gatekeepers. We consider how shifts in their discourse translate and amplify external social movement pressures for producers. We further argue that higher-status producers respond more to the changing discourse of these gatekeepers, to whom they are more tightly connected. This leads to a dynamic that is counterintuitive in the context of creative industries in which higher-status producers, who can benefit most from preserving the status quo, show greater responsiveness to external pressures when translated through gatekeeper discourse. Our empirical analysis uses a unique data set related to a prototypical contested practice: fur use in high-end fashion. These findings highlight the complex role of gatekeepers in creative industries and indirect pathways through which external social movements drive change. Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2022.1591 .
Prevalence of Strongyloides stercoralis infection and associated clinical symptoms among schoolchildren living in different altitudes of Amhara National Regional State, northwest Ethiopia
Authors: Jember Tadesse Hailu , Amor Arancha , Nibret Endalkachew , Munshea Abaineh , Flores-Chavez Maria , Ta-Tang Thuy-Huong , Saugar Jose M , Benito Agustín , Anegagrie Melaku 
Published: April 2022

Background
Strongyloides stercoralis is a parasite that causes strongyloidiasis in humans. It is prevalent in the tropics and sub-tropics where poor sanitation is a common problem. The true prevalence of S. stercoralis in Ethiopia is underestimated due to the lack of a “Gold” standard diagnostic method. Moreover, its prevalence across altitudinal gradient in Amhara Region has not been studied.

Methods
A cross-sectional study was conducted among 844 schoolchildren in Amhara Region from April to December 2019. A stool sample was collected from each study participant and processed using formol ether concentration technique (FECT), spontaneous tube sedimentation technique (STST), Baermann concentration technique (BCT), agar plate culture (APC) and real-time polymerase chain reaction (RT-PCR). Data were entered using EpiData and analyzed by SPSS version 23 statistical software. Prevalence of S. stercoralis infection was determined using a single diagnostic technique and combination of techniques. Association of clinical variables with S. stercoralis infection was assessed by logistic regression and independent variables with p<0.05 were considered statistically significant.

Results
Prevalence of soil-transmitted helminths (STHs) and S. mansoni infections was 38.0% and 20.4%, respectively. Among STHs, the prevalence of hookworm infection was 32.8%. Prevalence of S. stercoralis infection was 39.0%, 28.8%, 10.9%, 10.3%, 4.0% and 2.0% by the respective, combinations of the five methods, RT-PCR, APC, BCT, STST and FECT. The highest prevalence rates, 48.2%, 45.0% and 41.1% of S. stercoralis were recorded in the age group of 12–14 years, males and rural dwellers, respectively. Prevalence rates of S. stercoralis infection in highland, semi-highland and lowland areas were 40.4%, 41.8% and 25.9%, respectively. Having abdominal pain (AOR = 2.48; 95% CI:1.65–3.72), cough (AOR = 1.63;95%CI:1.09–2.42), urticaria (AOR = 2.49;95%CI:1.50–4.01) and being malnourished (AOR = 1.44;95%:1.10–2.01) were significantly associated with strongyloidiasis.

Conclusion
Prevalence of S. stercoralis infection was high and varied across different altitudes in Amhara Region. Some clinical syndromes were found to be significantly associated with S. stercoralis infection. Therefore, proper diagnosis and preventive strategies against S. stercoralis infection are highly recommended to be devised and implemented in Amhara Region.
Pericardiocentesis or surgical drainage: A national comparison of clinical outcomes and resource use
Authors: Pan Chelsea S. , Mabeza Russyan Mark , Tran Zachary , Lee Cory , Hadaya Joseph , Sanaiha Yas , Benharash Peyman 
Published: April 2022

Background
While institutional series have sought to define the optimal strategy for drainage of pericardial effusions, large-scale comparisons remain lacking. Using a nationally representative sample, the present study examined clinical and financial outcomes following pericardiocentesis (PC) and surgical drainage (SD) in patients admitted for pericardial effusion and tamponade.

Methods
Adults undergoing PC or SD within 2 days of admission for non-surgically related pericardial effusion or tamponade were identified in the 2016–2019 Nationwide Readmissions Database. Multivariable logistic and linear models were developed to evaluate the association between intervention type and outcomes. The primary outcome of interest was mortality while secondary endpoints included reintervention, periprocedural complications, hospital length of stay (LOS), hospitalization costs and 30-day non-elective readmission.

Results
Of an estimated 44,637 records meeting inclusion criteria, 28,862 (64.7%) underwent PC while the remainder underwent SD for initial management of pericardial effusion or tamponade. PC was associated with significantly increased odds of in-hospital mortality, reintervention and 30-day readmission relative to SD. PC was also associated with greater odds of cardiac complications but lower odds of infection, respiratory failure and blood transfusions compared to SD. Although PC was associated with shorter index hospital length of stay and costs, the two strategies yielded similar 30-day cumulative costs.

Conclusion
Management of pericardial effusion with PC is associated with greater odds of mortality, reintervention and 30-day readmission but similar 30-day cumulative costs compared to SD. In the setting of adequate hospital capability and operator expertise, SD is a reasonable initial treatment strategy for pericardial effusion.