bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of children’s thyroid equivalent doses in 16 municipalities after the Fukushima Daiichi Nuclear Power Station accident
Authors: Suzuki Gen , Ishikawa Tetsuo , Ohba Takashi , Hasegawa Arifumi , Nagai Haruyasu , Miyatake Hirokazu , Yoshizawa Nobuaki 
Published: September 2022

Abstract
To elucidate the association between radiation dose and thyroid cancer after the 2011 Fukushima Daiichi Nuclear Power Station (FDNPS) accident, it is essential to estimate individual thyroid equivalent doses (TEDs) to children. In a previous study, we reported a methodology for reconstructing TEDs from inhalation. That methodology was based on individual behavioral survey sheets of the Fukushima Health Management Survey (FHMS) combined with a spatiotemporal radionuclides database constructed by an atmospheric transport, diffusion, and deposition model (ATDM)—the Worldwide version of System for Prediction of Environmental Emergency Dose Information (WSPEEDI) in seven municipalities. In the present study, we further refined our methodology and estimated the combined TEDs from inhalation and ingestion among children in 16 municipalities around the nuclear power station utilizing 3256 individual whereabouts questionnaire survey sheets. Distributions of estimated TEDs were similar to estimates based on direct thyroid measurements in 1080 children in Iwaki City, Kawamata Town, Iitate Village, and Minamisoma City. Mean TEDs in 1-year-old children ranged from 1.3 mSv in Date City to 14.9 mSv in Odaka Ward in Minamisoma City, and the 95th percentiles varied from 2.3 mSv in Date City to 28.8 mSv in Namie Town. In the future, this methodology can be useful for the epidemiological studies of thyroid cancer after the FDNPS accident.
A genome-wide association study provides insights into fatty acid synthesis and metabolism in Malus fruits
Authors: Jiang Lijuan , Geng Dali , Zhi Fang , Li Zhongxing , Yang Yusen , Wang Yunlong , Shen Xiaoxia , Liu Xiuyun , Yang Yanqing , Xu Yange , Tang Yanlong , Du Rui , Ma Fengwang , Guan Qingmei , Zhang Jing 
Published: September 2022

Abstract
As a precursor of aromatic compounds, fatty acids play important roles in apple fruit quality; however, the genetic and molecular basis underlying fatty acid synthesis and metabolism is largely unknown. In this study, we conducted a genome-wide association study (GWAS) of seven fatty acids using genomic data of 149 Malus accessions and identified 232 significant signals (–log10P&gt;5) associated with 99 genes from GWAS of four fatty acids across 2 years. Among these, a significant GWAS signal associated with linoleic acid was identified in the transcriptional regulator SUPERMAN-like (SUP) MD13G1209600 at chromosome 13 of M. × domestica. Transient overexpression of MdSUP increased the contents of linoleic and linolenic acids and of three aromatic components in the fruit. Our study provides genetic and molecular information for improving the flavor and nutritional value of apple.
Epidemiology conduction of paediatric rheumatic diseases based on the registry database of the Pediatric Rheumatology Association of Japan
Authors: Narazaki Hidehiko , Akioka Shinji , Akutsu Yuko , Araki Mariko , Fujieda Mikiya , Fukuhara Daisuke , Hara Ryoki , Hashimoto Kunio , Hattori Seira , Hayashibe Ren , Imagawa Tomoyuki , Inoue Yuzaburo , Ishida Hiroyuki , Ito Shuici , Itoh Yasuhiko , Kawabe Tomohiro , Kitoh Toshiyuki , Kobayashi Ichiro , Matsubayashi Tadashi , Miyamae Takako , Mizuta Mao , Mori Masaaki , Murase Ayako , Nakagishi Yasuo , Nagatani Koji , Nakano Naoko , Nishimura Toyoki , Nozawa Tomo , Okamoto Nami , Okura Yuka , Sawada Hiromi , Sawanobori Emi , Sugita Yuko , Tanabe Yujiro , Tomiita Minako , Yamaguchi Ken-ichi , Yasuoka Ryuhei , Yokoyama Koji 
Published: September 2022

ABSTRACT

Objectives
Although epidemiological surveys of paediatric rheumatic diseases in Japan have been conducted, they were single surveys with no continuity. This is the first report of the Pediatric Rheumatology Association of Japan registry database, which was established to continuously collect data for paediatric rheumatic diseases.

Methods
Pediatric Rheumatology International Collaborate Unit Registry version 2 (PRICUREv2) is a registry database established by the Pediatric Rheumatology Association of Japan. The registry data were analysed for the age of onset, time to diagnosis, sex differences, seasonality, and other factors.

Results
Our data showed the same trend regarding rates of paediatric rheumatic diseases reported in Japan and other countries. The age of onset was lower in juvenile idiopathic arthritis (JIA) and juvenile dermatomyositis and higher in systemic lupus erythematosus and Sjögren’s syndrome. The time to diagnosis was relatively short in JIA and systemic lupus erythematosus but longer in juvenile dermatomyositis and Sjögren’s syndrome. Rheumatoid factor-positive polyarticular JIA showed a seasonality cluster with regard to onset.

Conclusion
PRICUREv2 aided the retrieval and evaluation of current epidemiological information on patients with paediatric rheumatic diseases. It is expected that the data collection will be continued and will be useful for expanding research in Japan.
Local assembly of long reads enables phylogenomics of transposable elements in a polyploid cell line
Authors: Han Shunhua , Dias Guilherme B , Basting Preston J , Viswanatha Raghuvir , Perrimon Norbert , Bergman Casey M 
Published: September 2022

Abstract
Animal cell lines often undergo extreme genome restructuring events, including polyploidy and segmental aneuploidy that can impede de novo whole-genome assembly (WGA). In some species like Drosophila, cell lines also exhibit massive proliferation of transposable elements (TEs). To better understand the role of transposition during animal cell culture, we sequenced the genome of the tetraploid Drosophila S2R+ cell line using long-read and linked-read technologies. WGAs for S2R+ were highly fragmented and generated variable estimates of TE content across sequencing and assembly technologies. We therefore developed a novel WGA-independent bioinformatics method called TELR that identifies, locally assembles, and estimates allele frequency of TEs from long-read sequence data (https://github.com/bergmanlab/telr). Application of TELR to a ∼130x PacBio dataset for S2R+ revealed many haplotype-specific TE insertions that arose by transposition after initial cell line establishment and subsequent tetraploidization. Local assemblies from TELR also allowed phylogenetic analysis of paralogous TEs, which revealed that proliferation of TE families in vitro can be driven by single or multiple source lineages. Our work provides a model for the analysis of TEs in complex heterozygous or polyploid genomes that are recalcitrant to WGA and yields new insights into the mechanisms of genome evolution in animal cell culture.
The interplay between maternal–infant anemia and iron deficiency
Authors: Davidson Eliza M , Simpson Julie A , Fowkes Freya J I 
Published: September 2022

AbstractIron deficiency anemia in pregnancy is a major public health problem known to cause maternal morbidity and adverse birth outcomes, and it may also have lasting consequences on infant development. However, the impact of the maternal hematological environment on fetal and infant hemoglobin and iron stores in the first year of life remains unclear. This review of the epidemiological evidence found that severe maternal iron deficiency anemia in pregnancy is associated with lower ferritin, and to a lesser degree hemoglobin levels, in infants at birth. Emerging data also suggests that severe anemia in pregnancy increases the risk of iron deficiency and anemia in infants 6–12 months of age, although longitudinal studies are limited. Effective anemia prevention in pregnancy, such as iron supplementation, could reduce the risk of infant anemia and iron deficiency during the first year of life; however, more evidence is needed to determine the functional impact of iron supplementation in pregnancy on infant hematological indices.
Corporate Reorganisation Law and the Shaping Powers of Market Realities and Doctrinal Concepts
Authors: Madaus Stephan 
Published: September 2022

Abstract
In Corporate Reorganization Law and Forces of Change, Sarah Paterson investigates the development of modern corporate reorganisation law in the United States and England and shows how, and why, the use of these laws has changed over time. Paterson argues that any analysis of corporate restructuring law must focus on the participants in the process and the way they mobilise and adapt legal rules in new ways to meet the problem of the day. She concludes that best practice, not doctrinal concepts, should inform any law reform in this area. This review concludes nonetheless with an attempt to identify a doctrinal concept of a modern restructuring law based on the insights of Paterson’s socio-legal analysis.
Extent of fibrosis and lung function decline in patients with systemic sclerosis and interstitial lung disease: data from the SENSCIS trial
Authors: Denton Christopher P , Goh Nicole S , Humphries Stephen M , Maher Toby M , Spiera Robert , Devaraj Anand , Ho Lawrence , Stock Christian , Erhardt Elvira , Alves Margarida , Wells Athol U 
Published: September 2022

Abstract

Objective
To assess associations between the extent of fibrotic interstitial lung disease (ILD) and forced vital capacity (FVC) at baseline and change in FVC over 52 weeks in patients with systemic sclerosis-associated ILD (SSc-ILD) in the SENSCIS trial.

Material and methods
We used generalized additive models, which involve few assumptions and allow for interaction between non-linear effects, to assess associations between the extent of fibrotic ILD on high-resolution computed tomography (HRCT), and the interplay of extent of fibrotic ILD on HRCT and FVC % predicted, at baseline and FVC decline over 52 weeks.

Results
In the placebo group (n = 288), there was weak evidence of a modest association between a greater extent of fibrotic ILD at baseline and a greater decline in FVC % predicted at week 52 [r: –0.09 (95% CI –0.2, 0.03)]. Higher values of both the extent of fibrotic ILD and FVC % predicted at baseline tended to be associated with greater decline in FVC % predicted at week 52. In the nintedanib group (n = 288), there was no evidence of an association between the extent of fibrotic ILD at baseline and decline in FVC % predicted at week 52 [r: 0.01 (95% CI: -0.11, 0.12)] or between the interplay of extent of fibrotic ILD and FVC % predicted at baseline and decline in FVC % predicted at week 52.

Conclusions
Data from the SENSCIS trial suggest that patients with SSc-ILD are at risk of ILD progression and benefit from nintedanib largely irrespective of their extent of fibrotic ILD at baseline.

Study registration
ClinicalTrials.gov, https://clinicaltrials.gov, NCT02597933.
Continued Posttrial Benefits of Buprenorphine Extended Release: RECOVER Study Findings
Authors: Boyett Brent , Nadipelli Vijay R. , Solem Caitlyn T. , Chilcoat Howard , Bickel Warren K. , Ling Walter 
Published: September 2022

Background
This analysis describes participants’ opioid use disorder (OUD) outcomes for 18 months after discontinuing extended-release buprenorphine injection (BUP-XR, SUBLOCADE).

Methods
The RECOVER (Remission From Chronic Opioid Use: Studying Environmental and Socioeconomic Factors on Recovery) study recruited participants from BUP-XR clinical trials (NCT02357901, NCT025100142, and NCT02896296) to assess whether there were sustained benefits after leaving the trial. Abstinence from opioids and from all illicit substances (excluding medical cannabis), health-related quality of life, depression, and employment were measured after BUP-XR discontinuation and change in outcomes assessed at 6, 12, and 18 months. Results were analyzed within the full cohort and by duration of BUP-XR treatment (0–2 months, 3–5 months, 6–11 months, 12 months, or 13–18 months) with and without inverse probability weights adjusting for differences in baseline characteristics.

Results
Of 533 participants, 529 were assessed over the 18-month study period. Further posttrial pharmacotherapy was reported by 33% of participants. At RECOVER baseline, longer BUP-XR was associated with higher abstinence (0–2 months BUP-XR [n = 116]: 38.8%; 3–5 months BUP-XR [n = 61]: 41.0%; 6–11 months BUP-XR [n = 86]: 68.6%; 12 months BUP-XR [n = 135]: 71.9%; 18 months BUP-XR [n = 131]: 88.2%) and greater 12-Item Short Form Health Survey mental component scores. Over 60% of participants had stable or improved outcomes at 6, 12, and 18 months assessments. Overall 47% of participants self-reported sustained opioid abstinence for the full 18-month follow-up, with greater sustained abstinence associated with longer BUP-XR treatment duration. A sensitivity analysis, removing patients receiving medications for OUD, yielded similar results.

Conclusions
Participants from BUP-XR clinical trials who continued into RECOVER maintained or improved on numerous outcomes over 18 months, demonstrating the long-term positive impact of OUD pharmacotherapy.
Autonomic Nervous System Function and Central Pain Processing in People With Frozen Shoulder
Authors: Mertens Michel G. , Struyf Filip , Lluch Girbes Enrique , Dueñas Lirios , Verborgt Olivier , Meeus Mira 
Published: September 2022

Objectives:
The pathophysiology of a frozen shoulder (FS) is thought to be related to chronic inflammation. Chronic inflammation may disturb the immune system and consequently the nervous system as part of an overarching system. The aim of this study was to determine the presence of disturbed autonomic nervous system function and altered central pain processing (CPP) in patients with FS. Secondarily, the presence of psychological variables (catastrophizing and hypervigilance) and self-reported associated symptoms of altered CPP in patients with FS were investigated.

Methods:
Patients with FS and healthy controls completed the Composite Autonomic Symptom Score (autonomic function) and underwent quantitative sensory testing to assess tactile sensitivity (ie, allodynia), pressure pain thresholds (PPTs, ie, hyperalgesia), temporal summation of pain, and Conditioned Pain Modulation (CPM). Psychological issues were explored with the Pain Catastrophizing Scale and the Pain Vigilance and Awareness Questionnaire, and self-reported symptoms associated with altered CPP were determined with the Central Sensitization Inventory.

Results:
Thirty-two patients with FS and 35 healthy controls were analyzed in the study. Patients with FS showed more self-reported autonomic symptoms and symptoms of altered CPP, higher levels of pain catastrophizing and hypervigilance, and are more sensitive to tactile touches and mechanical pressure compared with controls.

Discussion:
On the basis of the effect sizes, between-group differences in allodynia, hyperalgesia, catastrophizing, and hypervigilance were clinically relevant, but only local allodynia, hyperalgesia, catastrophizing, and hypervigilance were statistically different. Therefore, obvious altered CPP was not present at the group level in patients with FS compared with controls.
A National Survey of Neonatal Nurses' Knowledge, Beliefs, and Practices of Antibiotic Stewardship
Authors: Hamidi Maryam , Blatz Mary Ann 
Published: September 2022

Background:
In the neonatal intensive care unit, implementation of antibiotic stewardship programs has been challenging, especially for staff nurses.

Purpose:
To identify neonatal nurses' knowledge and attitudes toward antibiotic stewardship programs in neonatal intensive care units.

Methods:
This was a descriptive survey study to assess knowledge, attitudes, and beliefs of neonatal nurses related to antibiotic stewardship. The survey consisted of 23 questions, 6 of which were open-ended. The questions evaluated perceptions of general understanding of antibiotic stewardship, administration of antibiotics, information and perspective about antibiotic use, antibiotic resistance, and availability and usage of resources and education related to antibiotics. The survey was posted online for about 3 months on the Web site of a professional organization of neonatal nurses.

Results:
Of the 78 neonatal nurses who responded to the survey, 39% were very familiar with the term antibiotic stewardship. The majority of participants did not question the treating provider about the choice, route, or dose of antibiotics. The majority also agreed that more education is needed to achieve the goal of incorporating principles of antibiotic stewardship more fully into practice in the neonatal intensive care unit.

Implications for Practice:
Results suggest that although most nurses are familiar with the term antibiotic stewardship, they would like to have more education on the appropriate use of antibiotics.

Implications for Research:
Further studies are needed to identify nurse involvement in applying the principles of antibiotic stewardship programs while working with the vulnerable population of preterm infants.
Regional Variation in Access to Oncologic Care and Racial Disparities Among Cervical Cancer Patients
Authors: Alimena Stephanie , Davis Michelle , Pelletier Andrea , Terry Kathryn , King Martin , Feldman Sarah 
Published: September 2022

Objectives:
The goal of this study was to determine whether access to gynecologic oncologists is correlated with disparate outcomes among cervical cancer patients, especially among Black women.

Materials and Methods:
An ecological study was performed using the National Cancer Database among stage I-IVA cervical cancer patients from 2004 to 2014. Data from the National Cancer Institute, the Society of Gynecologic Oncology, and the United States Census were compiled to describe access to care by region. Factors associated with receipt of optimal treatment (defined as surgery and/or radiation for stage IA-IB1 and IIA1; radiation and chemotherapy for stage IB2, IIA2, IIB-IVA or node positive disease) were identified using multivariate logistic regressions stratified by region, controlling for confounding factors including the number of gynecologic oncologists per states in each subregion. Cox multivariate survival analyses stratified by region were also performed.

Results:
Of 42,213 women, 17.0% were Black. On multivariate analysis controlling for confounders, all Southern women were less likely to receive optimal treatment (adjusted odds ratio [aOR]: 0.80, 95% confidence interval [95% CI]: 0.75–0.85, P<0.001) compared with Northeastern women. Black women in the South (aOR: 0.76, 95% CI: 0.70–0.83, P<0.001) and Midwest (aOR: 0.78, 95% CI: 0.68–0.90, P<0.001) were less likely to receive optimal treatment compared with non-Black women in those regions. Black women in the South (adjusted hazard ratio [aHR]: 1.11, 95% CI: 1.04-1.18, P<0.001) and West (aHR: 1.34, 95% CI: 1.11–1.62, P=0.002) had worse mortality compared with non-Black women in those regions, despite controlling for access to gynecologic oncologists. The South, Midwest, and West had proportionally fewer cancer centers and gynecologic oncologists compared with the Northeast.

Conclusions:
Southern women are at risk of inadequate treatment for cervical cancer, and Black Southern women are at even higher risk of inadequate treatment and worse overall survival despite controlling for access to gynecologic oncologists. Social determinants of health and other barriers besides access to oncologists likely contribute to observed regional and racial disparities among cervical cancer patients.
Percutaneous nephrolithotomy and laparoscopic surgery efficacy and renal function outcomes for large and complex renal calculi
Authors: Pak Yuriy , Kalyagina Nina , Yagudaev Daniel 
Published: September 2022

Abstract

Background
There is limited published evidence regarding the incidence of intraoperative and postoperative events and the effect of percutaneous nephrolithotomy (PCNL) in supine and prone positions and laparoscopic pyelolithotomy on kidney function in patients with large and complex calculi.

Materials and methods
We evaluated the surgical outcomes of 97 patients with large and complex kidney stones. The patients were divided into 3 groups: those who underwent PCNL in the prone position, PCNL in the supine position, and pyelolithotomy by laparoscopy and retroperitoneoscopy. General surgical outcomes, size of residual stones, stone-free rate, glomerular filtration rate (GFR), and split GFR obtained from Tc-99m renal dynamic scintigrams were analyzed.

Results
Percutaneous nephrolithotomy in the prone position was correlated with improved function of the affected kidney. In the supine PCNL group, none of the analyzed indicators demonstrated a significant difference. Dynamic nephroscintigrams revealed negative changes in terms of accumulation and secretion of the affected kidney. A slight decrease in creatinine clearance was noted. However, positive dynamics in split GFR and secretory index were seen in this group. The laparoscopic group showed positive results in all analyzed parameters. However, full assessment of the function of the affected kidney in this group was limited due to restricted use of laparoscopic pyelolithotomy for complex stones.

Conclusions
Percutaneous nephrolithotomy in the prone position resulted in the most favorable renal functional outcomes for patients with high-grade renal calculi, whereas a laparoscopic approach may be preferred for patients with stones of lower grades. The most significant factors that adversely affected renal function were intraoperative bleeding volume, kidney stone size and density, and body mass index.
Cerebral venous thrombosis in a young asymptomatic COVID-19 patient
Authors: Dias Rafael , dos Reis Ricardo Soares , de Sousa Sara Pereira , Rocha Ana Filipa , Ribeiro Ana Margarida , Almeida Jorge 
Published: September 2022

Abstract
We report an unusual case of cerebral venous thrombosis (CVT temporally associated with an otherwise asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. While coronavirus disease 2019 (COVID-19) has been associated with thrombotic events at different sites, most published cases report on symptomatic SARS-CoV-2 infection. We are confident this was an otherwise asymptomatic infection as the patient reported no symptoms and molecular and serological testing was consistent with infection more than 3weeks in the past.
We believe this is an important report as it adds to the existing literature on thrombotic events in patients with COVID. It may even inform discussion of COVID vaccines and CVT since our patient, as those reported in association with vaccines, also had thrombocytopenia on admission.