bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nail Folds Capillaries Abnormalities Associated With Type 2 Diabetes Mellitus Progression and Correlation With Diabetic Retinopathy
Authors: Abd EL-Khalik Dina M , Hafez Eman A , Hassan Hanan E , Mahmoud Asmaa E , Ashour Doaa Maamoun , Morshedy Nashwa A 
Published: September 2022

Background: Diabetic retinopathy (DR) is an important microvascular consequence of long-term type 2 diabetes mellitus (T2DM), and it can lead to blindness if not properly diagnosed and managed. Nailfold video capillaroscopy (NVC) is a non-invasive technique for observing capillary microvasculature. Aim: We aimed to evaluate the nail folds capillaroscopic alterations in patients with T2DM by NVC and correlated the results to DR, and their relation to disease duration and hemoglobin A1c (HbA1c). Methods: This cross-sectional study enrolled 62 cases with T2DM (as per the American Diabetes Association criteria). All patients were subjected to NVC and ophthalmological assessment. Results: NVC revealed that Patients with DR showed significantly higher frequencies of tortuous capillaries, branched capillaries and precapillary edema versus non-DR patients with P < .05. The DR patients with longer disease duration (15-20) years had significantly higher frequencies of branched capillaries, tortuous capillaries, microhemorrhages, and dilated apical capillaries. The frequency of tortuosity and precapillary edema were significantly higher in patients with poor glycemic control. The increased capillary width and branched capillaries were detected as predictors of DR in multivariate analysis. Conclusion: NVC is a cost-effective, quick, safe, simple, non-invasive, and newly emerging tool to assess the capillaroscopic alterations in diabetic patients as an indicator of severity of DR.
Examining non-task language effect on production-based language switching: Evidence from Tibetan-Chinese-English trilinguals
Authors: Chen Jianlin , Wang Junzhao , Cairang Zhaxi , Xiong Yanyan , Zhang Congxia 
Published: September 2022

Aims and objectives/purpose/research questions: This study examined the non-task language effect in production-based language switching tasks by trilinguals using two of their languages. Non-task language refers to one of the languages of the trilinguals that is not used in a two-language switching task. Design/methodology/approach: Tibetan-Chinese-English participants (11th-grade high school students with a median age of 17) were recruited to perform picture naming tasks in three experiments, each with a different language pair of the trilinguals’ three languages (i.e., L1–L2, L2–L3, L1–L3). For each experiment, there were two groups of participants (30 for each group) with comparable proficiency in the two task languages but with significantly contrasted proficiency levels of the non-task language. Data and analysis: Each participant performed 216 trials and all together over 10,000 trials were used in the analysis of either the response times or the error rates in each experiment. Data of response times were analysed using linear mixed-effect models and data of error rates were analysed using logistic mixed models. Findings/conclusions: The response times and the error rates data across the three experiments revealed no main effect of non-task language proficiency, indicating a null effect of the non-task language. We proposed that a proactive language control mechanism might be used to overcome the interference from the non-task language. Originality: The non-task language effect in trilingual language switching is a rarely discussed topic. Significance/implications: This study is meaningful in evaluating the degree of generalizability of previous studies and can help gain insight into the underlying mechanisms of trilinguals’ language control.
HUNT for better public health
Authors: Krokstad Steinar , Sund Erik R. , Kvaløy Kirsti , Rangul Vegar , Næss Marit 
Published: September 2022

Aims: The Trøndelag Health Study (HUNT) has collected population data through comprehensive decennial surveys over the last four decades and has so far collected data from 240,000 participants. The participants are identified with the unique Norwegian birth number, which enables them to be followed throughout different life stages, from survey to survey, and to endpoint measures in Norwegian national health registers without attrition bias. Methods: The study design of HUNT offers several advantages: it provides an overview of the public health development in the population over decades, the data can be used in health services research, clinical epidemiology, studies of causation, trajectories, and consequences of diseases, and to study gene × environment interactions. Results: HUNT data have shown major shifts in public health trends, such as decreasing mean blood pressure and resting heart rate among adults, increasing prevalence of obesity, geographical and socioeconomic inequalities in health, increasing mental health distress among adolescents and young adults with an opposite development among the elderly. Data from HUNT have been used in several major international research projects, where data harmonization with several other population cohorts internationally has been done. HUNT has placed great emphasis on safeguarding research ethics, privacy, and data security. The Norwegian authorities established national regulations for the surveys from the time General Data Protection Regulation was introduced in 2018. Conclusions: Researchers can apply for HUNT data access from HUNT Research Centre provided they have obtained project approval from the Regional Committee for Medical and Health Research Ethics. Researchers not affiliated to a Norwegian research institution must collaborate with and apply through a Norwegian principal investigator. Information on the application and conditions for data access is available at www.ntnu.edu/hunt/data .
Initial clinical experience with a novel mechanical thrombectomy device-the ThrombX retriever
Authors: Behme Daniel , Wiesmann Martin , Nikoubashman Omid , Ridwan Hani , Hassan Dimah , Liebig Thomas , Trumm Christoph , Holtmannspötter Markus , Szikora Istvan 
Published: September 2022

Background and Purpose The ThrombX Retriever is a novel mechanical thrombectomy device that adjusts the distance between two mesh segments to axially hold thrombus. A post-market study assessed safety and performance in acute ischemic stroke patients with large artery occlusion. Methods A single-arm prospective multi-center study enrolled patients at 5 European Centers. Patients had a symptomatic large-artery occlusion of the intracranial Internal Carotid or the Middle Cerebral Artery, M1 segment. The primary outcome measure was the modified treatment in cerebral infarction (mTICI) score, on the immediate post-procedure angiogram after up to three device passes. Key secondary outcome measures were the mTICI score after a single pass and functional independence, defined as an mRS score ≤ 2 at 90 days. Results Thirty patients (16 Females, mean age 72 years), with NIHSS 4-25 (mean 15.5) were treated. Twenty-eight (93%) achieved mTICI 2b-3 within 3 passes, and 24 (80%) were with the first pass (FP). FP mTICI 2c-3 reperfusion was achieved in 19 (63%) cases. Seventeen of 24 (71%) patients treated with a balloon guide and the ThrombX Retriever had a FP mTICI 2c-3 reperfusion. After all interventions, mTICI 2b-3 was seen in 30 (100%) patients. Twenty-one of the 29 (73%) patients with 90-day follow-up were functionally independent (mRS≤2). No device-related serious adverse events were observed. Conclusion This preliminary study suggests the ThrombX Retriever is safe and has a high rate of substantial reperfusion. A larger prospective trial to assess the device effectiveness is planned.
Analgesic effect of recombinant GABAergic precursors releasing ω-conotoxin MVIIA in a model of peripheral nerve injury in rats
Authors: Jergova Stanislava , Hernandez Melissa , Sagen Jacqueline 
Published: September 2022

Development of chronic pain has been attributed to dysfunctional GABA signaling in the spinal cord. Direct pharmacological interventions on GABA signaling are usually not very efficient and often accompanied by side effects due to the widespread distribution of GABA receptors in CNS. Transplantation of GABAergic neuronal cells may restore the inhibitory potential in the spinal cord. Grafted cells may also release additional analgesic peptides by means of genetic engineering to further enhance the benefits of this approach. Conopeptides are ideal candidates for recombinant expression using cell-based strategies. The omega-conopeptide MVIIA is in clinical use for severe pain marketed as FDA approved Prialt in the form of intrathecal injections. The goal of this study was to develop transplantable recombinant GABAergic cells releasing conopeptide MVIIA and to evaluate the analgesic effect of the grafts in a model of peripheral nerve injury-induced pain. We have engineered and characterized the GABAergic progenitors expressing MVIIA. Recombinant and nonrecombinant cells were intraspinally injected into animals after the nerve injury. Animals were tested weekly up to 12 weeks for the presence of hypersensitivity, followed by histochemical and biochemical analysis of the tissue. We observed beneficial effects of the grafted cells in reducing hypersensitivity in all grafted animals, especially potent in the recombinant group. The level of pain-related cytokines was reduced in the grafted animals and correlation between these pain markers and actual behavior was indicated. This study demonstrated the feasibility of recombinant cell transplantation in the management of chronic pain.
A Review of 13,470 Head and Neck Injuries from Trampoline Jumping
Authors: Stanbouly Dani , Stanbouly Rami , Baron Michael , Selvi Firat , Chung Wen Raymond Wong , Chuang Sung-Kiang 
Published: September 2022

Study Design The authors designed a 20-year cross-sectional study using the National Electronic Injury Surveillance System (NEISS) database. Objective The purpose of the study is to determine the risk factors for hospital admission among individuals who suffer head and neck injuries secondary to trampoline use. Methods The primary predictor variables were a set of heterogenous variables that were categorized into the forementioned study variable groups (patient characteristics and injury characteristics). The primary outcome variable was hospital admission. Multivariate logistic regression was used to determine independent risk factors for hospital admission. Results The final sample consisted of 13,474 reports of trampoline injuries to the head and neck. Relative to females, males (OR 1.66, P < .05) were at an increased risk for hospital admissions. Fractures (OR 35.23, P < .05) increased the risk for hospital admissions relative to dental injuries. Concerning anatomical region of injury, neck injuries (OR 30.53, P < .05) were at an increased risk for hospital admissions. Conclusions Injuries to the neck from trampoline jumping significantly increased the risk for admission. The severity of neck injuries from trampoline jumping is well established in the literature. Additionally, male sex and fractures were each risk factors for hospital admission. Given the rising prevalence of trampoline-related head and neck injuries over the past 2 decades, it is crucial for individuals to take the necessary precautions when jumping on a trampoline.
Assessment of intestinal parasites and associated factors among HIV/AIDS patients on antiretroviral therapy at Bule Hora General Hospital, West Guji, Ethiopia
Authors: Aliyo Alqeer , Gemechu Tibeso 
Published: September 2022

Objective: The study aimed to assess the prevalence of intestinal parasites and associated factors among people living with HIV/AIDS on antiretroviral therapy at Bule Hora General Hospital, West Guji, Oromia, Ethiopia. Introduction: Parasitic infection of the intestinal tract is a major source of disease in patients with HIV, particularly in the tropics, where diarrhea is a common complaint with variable severity. Method: An institution-based cross-sectional study was conducted from May to August 2021 on 179 systematic randomly selected HIV patients. Data on sociodemographics were collected by interviewing the study subjects using a pretested structured questionnaire. Stool specimens were collected from the study subjects and processed and examined by formol-ether concentration techniques. Data were obtained from each individual using data sheets and then entered into SPSS version 20 for analysis. The chi-square test was calculated, and a p value <0.05 was considered statistically significant. Results: Out of 179 study subjects, 52 (29.1%) were infected with intestinal parasites. The most frequently detected parasites were Giardia lamblia (38.5%) and Ascaris lumbricoides (25%) Entamoeba histolytica/dispar (15.4%), followed by Strongyloides stercoralis (11.5%). Factors such as the CD4+ T-cell status and source of drinking water were significantly associated with the prevalence of intestinal parasites among HIV/AIDS patients. The prevalence of intestinal parasites was highly observed among patients who scored CD4+ T cells <200 cells/mm3 90.4% (47/52) and drink ground water 73.1% (38/52). Conclusion: There was moderate prevalence of intestinal parasites among HIV/AIDS patients; therefore, treating unprotected water before drinking and diagnosis of early parasites for HIV/AIDS patients whose CD4+ T-cell count is less than 200 cells/mm3 should be practiced to prevent intestinal parasite infection.
Determinants of meconium aspiration syndrome among neonates admitted to neonatal intensive care unit at Nigist Eleni Mohammed Memorial Comprehensive Specialized Hospital, South Ethiopia: Unmatched case–control study
Authors: Awgchew Seife , Ezo Elias 
Published: September 2022

Objective: To identify determinants of meconium aspiration syndrome among neonates admitted to the neonatal intensive care unit at Nigist Eleni Mohammed Memorial Comprehensive Specialized Hospital, South Ethiopia, in 2022. Method: A facility-based unmatched case–control study was used to identify meconium aspiration syndrome with a total sample size of 249 from January to April 2022. Data were entered by using EpiData version 3.1 and analyzed using SPSS version 24 software. Descriptive findings were presented by frequency tables and percentages. Multicollinearity was checked and the goodness of fit test was done. To determine the independent determinants associated with meconium aspiration syndrome, bivariate analysis was done and variables with a p value of <0.05 were taken to multivariate logistic regression analysis. Adjusted odds ratio with a 95% confidence interval was calculated, and statistical significance was declared at a p value less than 0.05. Result: Two hundred forty-nine (83 cases and 166 controls) mothers with their respective neonates were included in this study and that made the overall response rate 100%. Preeclampsia (adjusted odds ratio: 3.35, 95% confidence interval: 1.02, 10.97), antepartum hemorrhage (adjusted odds ratio: 3.63, 95% confidence interval: 1.50, 8.78), duration of labor (adjusted odds ratio: 4.34, 95% confidence interval: 1.83, 10.30), premature rupture of membrane (adjusted odds ratio: 16.02, 95% confidence interval: 5.66, 45.29), and obstructed labor (adjusted odds ratio: 4.57, 95% confidence interval: 1.42, 14.70) were determinants of meconium aspiration syndrome. Conclusion: In this study, preeclampsia, antepartum hemorrhage, duration of labor, premature rupture of membrane, and obstructed labor were determinants of meconium aspiration syndrome. Therefore, to reduce the risk of meconium aspiration syndrome, prevention, early identification, and management of these obstetrical factors may help to reduce meconium aspiration syndrome locally.
Factors affecting doctor’s recommendation for mobile health services
Authors: Hu Xiaojing , Fang Hongjun , Wang Ping 
Published: September 2022

Objective As a new medical service mode, the value of mobile health (mHealth） services has received increasing attention and recognition. However, compared with the owners of mobile devices, the user scale of mHealth services is still small. It is well known that doctors’ recommendations have an important impact on what kind of medical service patients choose. To explore the key factors affecting doctors’ recommendation of mHealth services to patients, and to provide countermeasures for mHealth service providers and hospital managers, so as to promote doctors to recommend mHealth services to more patients. Methods Through literature review, expert consultation and pre-test, a questionnaire including 22 questions was designed, and 114 valid questionnaires were collected by online research. Net Promoter Score (NPS) was used to evaluate doctors’ recommendation willingness, and multivariate logistics analysis was used to evaluate the key factors affecting doctors’ recommendation willingness. Results The NPS of doctors was 6.06%, among which the recommenders, neutrals and critics accounted for 29.56%, 46.96% and 23.48%, respectively. The attitude towards mHealth services and whether they pay attention to and/or are willing to try new technologies are the key factors affecting the doctors’ recommendation, and the usefulness for patients most often emphasized by mHealth service providers to doctors does not affect doctors’ recommendation willingness. In addition, whether mHealth services can help doctors establish personal brands may be a potential factor to enhance doctors’ recommendation willingness. Conclusion In order to improve the recommendation willingness of doctors, mHealth service providers and hospital managers should focus on doctors who have a positive attitude towards mHealth services and are highly innovative (which often means younger and lower professional levels). At the same time, they should think about how to use mHealth services to help doctors establish personal brands in the future.
Epidemiology With Video Analysis of Knee Injuries in the Women’s National Basketball Association
Authors: Axelrod Kobi , Canastra Neal , Lemme Nicholas J. , Testa Edward J. , Owens Brett D. 
Published: September 2022

Background: Knee injuries are the most common type of injury seen in the Women’s National Basketball Association (WNBA). However, there are sparse epidemiologic data regarding these injuries over the past 20 years. Purpose/Hypothesis: The purpose of this study was to determine the prevalence, return to play (RTP) rate/length, and mechanism of knee injuries in the WNBA. We hypothesized that anterior cruciate ligament (ACL) tears would have the highest prevalence and longest RTP times. Study Design: Descriptive epidemiology study. Methods: Publicly available WNBA injury reports were used to find WNBA athletes who sustained knee injuries. The RTP length was determined by calculating the number of days between the date of the injury and the date of the first game they played after returning. The RTP rate was determined by calculating the number of players who returned to play from each injury compared with the total number of each injury. Incidence of knee injuries, frequency, and time to RTP were calculated for each injury. Available videos were analyzed to determine the mechanism and body position at the time of injury. Results: Overall, 99 WNBA players were identified as having sustained a knee injury during the study period resulting in loss of play. ACL tears (n = 37; 37%) were the most devastating injury, resulting in the longest time before RTP (n = 375 days; 70%). The position with the highest incidence of knee injuries was guard, accounting for 53% of knee injuries. Video analysis conducted on 12 knee injuries revealed that such injuries were most commonly noncontact (83%).The mechanisms of injury were most commonly planting (58%) and landing from a jump (33%) with the knee flexed in the valgus position (100%). Conclusion: Study findings indicated that ACL tears are the most common clinically significant knee injuries sustained in the WNBA, accounting for 37% of total knee injuries with a mean RTP rate of 375 days. The most common mechanism of injury was planting the foot or landing from a jump with a flexed knee in the valgus position. Knee injuries had a high RTP rate in WNBA players but resulted in them missing a significant amount of playing time.
Translation, Validity, and Reliability of the Dutch Anterior Cruciate Ligament–Quality of Life Questionnaire
Authors: de Vries Astrid J. , Brouwer Reinoud W. , Veld Rianne Huis in t’ , van der Wal Wybren A. , Reininga Inge H.F. , Hoogeslag Roy A.G. 
Published: September 2022

Background: The Anterior Cruciate Ligament–Quality of Life (ACL-QoL) questionnaire is a valid and reliable injury-specific instrument to assess the impact of an ACL rupture on the daily life of a patient. Purpose: To translate the ACL-QoL into Dutch (ACL-QoL-NL) and to study its psychometric properties in patients with an ACL rupture. Study Design: Cohort study (diagnosis); Level of evidence, 2. Methods: The original ACL-QoL questionnaire was translated from English to Dutch according to international guidelines. The study population consisted of 122 patients with a confirmed ACL rupture who completed the ACL-QoL-NL as well as 4 questionnaires: the International Knee Documentation Committee subjective score, Knee injury and Osteoarthritis Outcome Score, 36-item Short Form Health Survey, and Lysholm Knee Score. We determined the internal consistency, construct validity, and prevalence of floor and ceiling effects of the ACL-QoL-NL total score as well as its 5 subscales. To determine test-retest reliability, we analyzed the data of 68 patients who had a stable knee condition and who completed the ACL-QoL-NL a second time after a 2-week interval. Results: The confirmatory factor analysis showed that the original structure of the ACL-QoL-NL was confirmed, except for 4 of 31 items. Internal consistency of the total scale and all 5 subscales was good. More than 75% of the predefined hypotheses on the correlations between the ACL-QoL-NL and the 4 questionnaires were met, indicating good construct validity. No significant floor or ceiling effects were observed. Test-retest reliability was good, and no systematic bias between test and retest was found. Standard error of measurement for the total score was 4.8 points out of 100, and the smallest detectable changes at the group and individual levels were 1.6 and 13.2 points, respectively. Conclusion: The ACL-QoL-NL questionnaire was successfully translated from English to Dutch and demonstrated good internal consistency, validity, and reliability, with no presence of floor or ceiling effects.