bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparative Study of Centralized and Distributed Battery Approach in Multi-Energy Harvesting System for UWSN
Authors: Saleem Azizullah , Akkan Taner , Akkan L. Ozlem Karaca 
Published: March 2022

Abstract
Underwater sensor network (UWSNs) has sensors and mobile wireless transceivers deployed in under and upper water areas to perform data monitoring and acquisitions. With the emerging technologies UWSNs has many different specific underwater applications. But there are problems and challenges facing underwater environment such as propagation delays, energy limitation, narrow bandwidth, and node mobility. Various protocols have been developed to deal with these issues. Energy consumption is one of the main problems in underwater wireless sensor network as the nodes’ batteries have limited amount of energy. Furthermore, batteries cannot be replaced easily as replacement cost is very high and batteries have high weight. To solve energy consumption problem, firstly multi power harvesting system is developed and optimized using genetic optimization, followed by design of wireless sensor nodes battery energy level model based on multi energy harvested system and its application to centralized and distributed system is investigated and finally followed by discussion and conclusion.
Alpha, Beta, and Gamma Oscillations in Cortical Communication During Motor Preparation
Authors: Zhao Yun , Wilkins Kevin , Yao Jun 
Published: March 2022

Abstract
Motor cortices prepare movements by rotating activity from one region into another via synchronized firing at different frequencies, primarily involving α, β and γ bands. Previous results in non-disabled participants showed that although within β-band couplings in contralateral motor cortices dominant cortical activities for hand opening task, α-β and γ-β couplings are presented for more complex tasks. These findings raise the question whether α and γ bands play a modulation role on the β-oscillation during the motor preparation for an “un-established” task. To test this question, we compared the cortico-cortical-communication during motor preparation for hand opening between the non-disabled and stroke groups. Twelve stroke individuals who cannot open hand sufficiently and eleven age-matched non-disabled individuals performed a maximal hand opening with a high-density EEG measure. The non-disabled group expressed the exclusive within-β communications primarily within contralateral motor areas. Differently, the stroke group showed complex couplings across both hemispheres involving α, β and Gamma bands. These findings suggest that a cortical preparatory β communication may reflect using a well-established internal model. However, when the internal model does not work sufficiently, bilateral α and γ-band modulation to the β oscillation occurs, demonstrating the learning and adjustment to the motor plan.
Tick borne microbial agents in Iran and the adjacent countries: A meta- analysis based on the GenBank database
Authors: Hosseini-Chegeni Asadollah 
Published: March 2022

Abstract
In this review study a novel approach was used while in most classical review the results of published articles are analyzed. This paper uses only microbial sequence data registered (having accession number) in the GenBank database. The results of this study play an important role in informing the public health and veterinary diagnostic systems for the entry of microbial agents through invasive infected ticks into the country through livestock and wild animals’ movement and the migratory birds.
Estimation Formula for Preparation Time of Anesthesia Induction Surgery Accounting for Clinical Department Factors in Optimal Surgery Schedule Management
Authors: Tachibana Reika , Kaneko Shohei , Yamaguchi Michiko , Fujioka Masaki , Kuroki Tamotsu , Honda Sumihisa , Sawai Terumitsu , Hara Kentaro 
Published: March 2022

Abstract

Background: Efficient management of the operating room is crucial, and it necessitates accurate scheduling of surgeries. We hypothesized that it would be possible to develop an estimation formula for the preparation time of anesthesia induction surgery by incorporating not only the anesthesia factors and the surgical factors, but also “clinical department” as a factor in the estimation formula.Materials and methods: This was a retrospective observational study that analyzed 7921 scheduled surgical cases. Regression analysis using clinical department, six anesthesia factors and five surgical factors was performed to develop an analysis and an equation for estimating the time required for anesthesia induction surgery.Results: Our estimation formula wielded high accuracy (R2 = 0.808). Particularly, there was only a difference of less than 3 minutes for surgeries under general anesthesia. In addition, modeling preparation time using “medical interventions performed in the operating room” as a factor instead of patient characteristics was found to be beneficial.Conclusions: It was possible to develop a highly accurate formula for estimating preparation time of anesthesia induction surgery by analyzing the anesthesia factors and the surgical factors and incorporating the clinical department as an estimation factor.
Dual Specificity Phosphatase 1 (DUSP1) Provides Mechanistic Link Between Melanoma Cellular Plasticity and Drug Resistance
Authors: Setaluri Vijayasaradhi , Singh Mithalesh K. , Altameemi Sarah , Lares Marcos , Newton Michael A. 
Published: March 2022

Abstract
Melanoma cells exhibit phenotypic plasticity that allows transition from a proliferative and differentiated phenotype to a more invasive and undifferentiated or transdifferentiated phenotype often also associated with drug resistance. The mechanisms involved in melanoma phenotype plasticity and its role in drug resistance are not fully understood. We previously demonstrated that the MAPK inhibitors (MAPKi)-resistance phenotype is associated with decreased expression of stem cell proliferation genes and increased expression of MAPK inactivation genes, including dual specificity phosphatases (DUSPs). Several members of the DUSP family genes, specifically DUSP1, -3, -8 and -9, are expressed in primary and metastatic melanoma cell lines and pre-and post BRAFi treated patient tumor cells. Here, we show that was knockdown of DUSP1 or DUSP8 or treatment with BCI, a pharmacological inhibitor of DUSP1/6 decreases the survival of MAPKi-resistant cells and sensitizes them to MAPKi. We also show that nestin, a neural crest stem cell marker, and MAP2, a neuronal differentiation marker, are downregulated in MAPKi-resistant cells whereas GFAP, a glial cell marker, present in both MAPKi-sensitive and -resistant cells. Inhibition of DUSP1/6 upregulated nestin expression in MAPKi-sensitive cells and cells with acquired resistance. In contrast, treatment with BCI caused upregulation of MAP2 in MAPKi-sensitive cells and downregulation of both MAP2 and GFAP in all MAPKi-resistant cell lines. These data suggest that DUSP1/6 are involved in melanoma neuronal transdifferentiation serve as mechanistic link between melanoma drug resistance and melanoma differentiation and targets for treatment of MAPKi-resistant melanoma.
Relationship between type of injured organ and development of abdominal compartment syndrome after severe blunt abdominal trauma: a nested case-control study using nationwide trauma registry in Japan
Authors: Komori Akira , Iriyama Hiroki , Kainoh Takako , Aoki Makoto , Abe Toshikazu 
Published: March 2022

Abstract
Background: Abdominal compartment syndrome (ACS) after blunt abdominal trauma is a rare complication that requires early recognition and subsequent surgical intervention for optimal outcome. We aimed to investigate how differences in injured abdominal organs affect ACS development in patients with severe blunt abdominal trauma.Methods: This nested case-control study used a nationwide registry of trauma patients, namely, the Japan Trauma Data Bank (JTDB), and only included patients aged ≥ 18 years with blunt severe abdominal trauma, defined as an AIS score of abdomen ≥ 3, sustained between 2004 and 2017. Patients without ACS were used as control subjects and identified using propensity score (PS) matching. Characteristics and outcomes between patients with and without ACS were compared and logistic regression was used to identify specific risk factors for ACS.Results: Among 294,274 patients in the JTDB, 11,200 were eligible for inclusion before PS matching, and 150 (1.3%) developed ACS after trauma. PS matching led to the inclusion of 131 and 655 patients with and without ACS, respectively. Compared to controls, patients with ACS had higher number of injured organs in the abdomen and displayed a greater frequency of vascular and pancreatic injuries, need for blood transfusion, and disseminated intravascular coagulopathy, a complication of ACS. In-hospital mortality was higher in patients with ACS than those without ACS (51.5% vs. 24.4%, p < 0.01). Logistic regression analysis revealed that a higher number of injured organs in the abdomen [odds ratio (OR) (95% confidence interval [CI]): 1.71 (1.22–2.40)] and pancreatic injury [OR (95% CI): 1.44 (1.03–2.03)] were independently associated with ACS.Conclusions: Greater number of injured organs in abdomen and pancreatic injury are independent risk factors for the development of ACS; injuries to other organs were not associated.
Sotrovimab neutralizing SARS-CoV-2: Risk factors for post-infusion clinical events
Authors: Yoshida Junichi , Shiraishi Kenichiro , Noda Hirotaka , Otani Kazuhiro , Kikuchi Tetsuya , Mataga Akiko , Ueno Takako , Tanaka Masao 
Published: March 2022

Abstract
Background Sotrovimab has been developed to neutralize SARS-CoV-2 which remained effective at the advent of B.1 lineage of the Omicron variant. To investigate post-infusion clinical events and their risk factors, we performed a retrospective study.Methods Subjects were a consecutive series of inpatients with COVID-19 undergoing an infusion of sotrovimab in our institute. In accordance with previous clinical trials, we included patients at risk but permitted SARS-CoV-2 vaccinees. For statistical analyses, we reviewed background factors of demographics, imaging, and laboratory findings for the outcome of post-infusion events such as temperature over 38 degrees Celsius (Temp38) and pulse oximetry below 94%.Results Of a total of 136 patients, the median follow-up was 47 days. Among 110 fully vaccinated patients (80.9%) for SARS-CoV-2, 2-time vaccinees accounted for 88 while 3-time vaccinees were 22. Three patients (2.2%) showed worsening of COVID-19; one developed hypoxia and two died. For the outcome of Temp38 (N=41), multivariate analysis showed that factors at risk were younger age (<66.5) (Odds Ratio [OR] 4.364, 95% Confidence Interval [CI] 1.562 – 12.194, P=0.005) and pre-infusion temperature more than 36.7 degrees Celsius (OR 7.256, 95% CI 2.695 – 21.455, P<0.001). For post-infusion reduced oximetry (N=17), symptomatic days (>2) (OR 8.657, 95% CI 1.030 – 72.786, P=0.047) and pulse oximetry (<96.5%) (OR 7.160, 95% CI 2.071 – 24.751, P=0.002) were at risk. Oxygen was supplied for a median of 1.5 days (range, 1 - 5). We observed vomiting (N=1) and elevated aminotransferase levels (N=1). Conclusions With fully vaccinated patients predominant, antibody-dependent enhancement may have brought about post-infusion fever in the younger population prone to increase antibody titers. Likewise, patients undergoing delayed infusion after symptom onset may have produced antibody, leading into respiratory distress or lowered oximetry. Limitations for this study included inherent difficulty in distinguishing AE from worsening of COVID-19. Thus for 24 hours after infusion of sotrovimab, COVID-19 patients younger than 66.5 years may have temperature elevation, indicating the need for preparation of post-infusion fever. Those undergoing infusion after 3 symptomatic days or more may develop an oximetry decrease, thus demanding pulse oximetry monitoring.
Reciprocal exchanges involving virion and complementary sense genes, the LIR and SIR between the two clones of maize streak mastrevirus result in ameliorated symptoms in maize
Authors: Edema Richard , Gordon Donald T. 
Published: March 2022

Abstract
A genetic analysis of maize streak mastrevirus (MSV) virulence was conducted using two infectious DNA clones derived from isolates collected in Kenya. Virulence was tested on the susceptible Pioneer hybrid 3379 using vascular puncture inoculation of kernels. Marked differences in the severity of chlorotic streaks and stunting of seedlings were associated with mild [pMSV-KL (mild)] and severe [pMSV-Km(severe)] parental infectious MSV DNA clones. To identify determinants conditioning these differences, chimeric clones were constructed from parental clones employing restriction endonuclease fragments. Clone identities were confirmed by restriction mapping. Putative virulence determinants were identified for genomic fragments encoding the replication initiator (Rep and RepA), movement (MP) and coat (CP) protein ORFs and for those containing non-coding long (LIR) and short intergenic regions (SIR). Recombinant clones containing LIRs plus the 5'–terminus of Rep/RepA (first 189 nt) ORFs from pMSV-Km(Severe) and pMSV-KL(Mild) reciprocally exchanged displayed intermediate symptoms. Complementary replacement of the Rep/RepA ORF resulted in symptoms indistinguishable from those of parental clones. The recombinant clone constructed with LIR, Rep and RepA genome sequences from pMSV-Km(Severe) and MP, CP and SIR sequences from pMSV-KL(Mild) showed significantly more severe symptoms and accumulated higher concentrations than pMSV-Km(Severe). In contrast, the reciprocal clone showed significantly milder symptoms and lower viral titers than pMSV-KL(Mild). Viral accumulation was correlated with the intensity of leaf chlorosis and the degree of plant stunting. These data support the hypothesis that MSV virulence is a polymorphic trait involving virion and complementary sense genes (LIR and SIR).
Effect of organic load regulation on anaerobic digestion performance and microbial community of solar-assisted system of food waste
Authors: Zhen Xiaofei , Luo Miao , Dong Haiying , Fang Lei , Wang Weiwei , Feng Lei , Yu Qin 
Published: March 2022

Abstract
The semi-continuous digestion experiment of food waste was carried out based on a solar-assisted heat anaerobic digestion reactor. The effects of organic load regulation (OLR of 2.0, 4.0, 6.0 and 7.0 kg m−3 d−1 VS (volatile solid)) on methane production, physical and chemical parameters, and microbial community structure were studied. The results showed that 6.0 kg m−3 d−1 VS could achieve the optimal methane production as the anaerobic digestion limit OLR of kitchen waste. At this stage, the accumulation of organic acids in the reactor led to a great fluctuation of pH. Artificial alkali regulation could restore the stable operation of the reactor, but the reactor could not withstand the OLR shock of 7.0 kg m−3 d−1 VS. In addition, Qualcomm sequencing results showed that microorganisms showed high functional concentration and poor community richness under low OLR, and increasing OLR could promote microbial richness. At the same time, the Methanosaeta of acetic acid methanogens was relatively abundant in the low OLR stage, while the hydrogen trophic methanogenic bacteria Methanoregula and Methanospirillum showed high activity in the high OLR stage, but the excessive reproduction of acidogenic bacteria in the digestive system would affect the stability of the archaea community when the OLR was too high.
Dynamics of Spatial Inequality in the Development of us Healthcare and State Regional Policy
Authors: Minat V. N. 
Published: March 2022

One of the key aspects that reveals the essence of the uneven distribution of social benefits in economically developed countries is the dynamics of spatial inequality that has been characteristic of the US healthcare sector for many decades. The results of an empirical study of this inequality as a dynamic process with the properties of historicism, carried out by decomposition of the Theil index according to the intragroup and intergroup characteristics of the corresponding groups of indicators, indicate an increase in the polarization of territories in terms of the provision of the population with medical benefits. Given the organizational and economic inconsistency in the health care of American citizens and the predominance of the spontaneous and commercial nature of free pricing in the relevant markets of American medical goods and services, the center-peripheral spatial structure of inequality in the development of US health care, traditional for capitalist reproduction, is confirmed.The objective nature of the long-term formation of such a structure is complemented by the subjective factor of state regional regulation of health care in the subregional and transregional sections, through the implementation of differently directed typologically relevant policies – from traditional and proactive to selective. It is shown that not only the economic situation, but also the socio-political and ideological expediency are the subjects that determine the tools for activating, polarizing, stimulating or restraining the development of healthcare in specific areas of the United States.
Marine Polysaccharides in Tailor-made Drug Delivery
Authors: Manna Sreejan , Jana Sougata 
Published: March 2022

Abstract:
Marine sources have attracted much interest as an emerging source of biomaterials in drug delivery
applications. Amongst all other marine biopolymers, polysaccharides have been the most investigated class of
biomaterials. The low cytotoxic behavior, combined with the newly explored health benefits of marine polysaccharides,
has made it one of the prime research areas in the pharmaceutical and biomedical fields. This review
focused on all available marine polysaccharides, including their classification based on biological sources. The
applications of several marine polysaccharides in recent years for tissue-specific novel drug delivery, including
gastrointestinal, brain tissue, transdermal, ocular, liver, and lung, have also been discussed here. The abundant
availability in nature, cost-effective extraction, and purification process, along with a favorable biodegradable
profile, will encourage researchers to continue investigating marine polysaccharides to explore newer applications
targeting the specific delivery of therapeutics.
Recent Advances in Pinacol Rearrangement
Authors: Jin Ye , Liu Mao , Cong Hang , Ge Qingmei 
Published: March 2022

Abstract:
A pinacol rearrangement is a well-known reaction by which a 1,2-diol is converted
to a carbonyl compound through acid-catalyzed dehydration followed by a 1,2-migration of
one of the neighboring substituents. Due to the particular abilities in installing polycyclic skeletons,
quaternary carbon centers, and spirocyclic cores, the pinacol rearrangement reaction is a
powerful and effective means of forming carbonyl functional groups in a variety of different
molecules. Moreover, the substrates with an alkene group, a furan ring or alkyl chain tethered
between the two diols have also been investigated as the expansion of pinacol rearrangement.
Benefiting from the continuous development of the catalysis methodologies, pinacol rearrangements
demonstrate synthetic utility in the preparation of natural products, bioactive molecules,
and other functionally useful compounds. In this review, we discuss recent advances in
the development of pinacol rearrangement and extended pinacol rearrangement reactions catalyzed by Brønsted
acid, Lewis acid, and heterogeneous catalysts. In addition, we summarize several examples use pinacol rearrangements
used in the synthesis of natural products and other valuable molecules.
Mechanism Research of Platelet Core Marker Prediction and Molecular
Recognition in Cardiovascular Events
Authors: Qin Dui , Li Zhangyong , Wang Hongdan , Zhang Bingyu , Zhong Xianhua 
Published: March 2022

Background:
Thrombosis triggered by platelet activation plays a vital role in the pathogenesis
of cardiovascular and cerebrovascular diseases.

Objective:
This study aims to find platelet combined biomarkers for cardiovascular diseases and
investigate the possibility of Concanavalin A (ConA) acting on platelets as a new pharmacological
target.

Methods:
High-throughput Technology and bioinformatics analysis were combined and groups of
microarray chip gene expression profiles for acute myocardial infarction (AMI) and sickle cell disease
(SCD) were obtained using GEO database screening. R language limma package was used to
obtain differentially expressed genes (DEGs). GO, KEGG, and other databases were utilized to
perform the enrichment analysis of DEGs’ functions, pathways, etc. PPI network was constructed
using STRING database and Cytoscape software, and MCC algorithm was used to obtain the 200
core genes of the two groups of DEGs. Core targets were confirmed by constructing an intersection
area screening. A type of molecular probe, ConA, was molecularly docked with the above core targets
on the Zdock, HEX, and 3D-DOCK servers.

Result:
We found six core markers, CD34, SOCS2, ABL1, MTOR, VEGFA, and SMURF1,
which were simultaneously related to both diseases, and the docking effect showed that VEGFA is
the best-performing.

Conclusion:
VEGFA is most likely to reduce its expression by binding to ConA, which could affect
the downstream regulation of the PI3K/Akt signaling pathway during platelet activation. Some
other core targets also have the opportunity to interact with ConA to affect platelet-activated
thrombosis and trigger changes in cardiovascular events.
A Review of Biological Applications of Transition Metal Complexes Incorporating
N-acylhydrazones
Authors: Hamzi Imane 
Published: March 2022

Abstract:
In view of the crucial importance of the bioactivities of N-acylhydrazone derivatives and
their corresponding metal complexes, N-acylhydrazones have recently attracted the attention of researchers
in the chemical, biological, and pharmaceutical fields. This review aims to describe Nacylhydrazone
complexes involving transition metal ions, such as copper, chromium, manganese,
iron, cobalt, nickel, and zinc, and investigate their properties and possible applications in various domains.
The most promising applications of the number of transition metal complexes incorporating Nacylhydrazones
in biology, medicine, and pharmacology are also examined and determined.
Research Progress on the Application of Magnetic Nanomaterials in Water
Pollution Control
Authors: Li Xiang , Xie Shiyu , Zeng Guoming , Khan Sarfaraz 
Published: March 2022

Abstract:
With the increasing shortage of water resources and the improvement in people's awareness
regarding environmental protection, the traditional water pollution control technology cannot
meet the needs of the development of environmental protection. In recent years, the rapid development
of nanotechnology and nanomaterials has provided a good opportunity for the innovation of
water treatment technology and has attracted the extensive attention of many environmental researchers.
In particular, new functional magnetic nanomaterials with good adsorption properties,
good chemical stability, easy regeneration, and easy solid-liquid separation have become hot topics
in the field of water pollution control. This paper aims to provide the present research progress of
magnetic nanomaterials in water pollution control, including the striking characteristics and preparation
methods of the most well-known magnetic nanomaterials, as well as their applications in the water
pollution control field. Concluding remarks and future trends have also been pointed out.