bluuebunny/crossref_metadata_2025_split huggingface dataset:
Joint inversion of VES and Rayleigh wave data based on improved DE algorithm for near surface exploration
Authors: Hu Benna , Wen Laifu , Zhou Xuemei 
Published: December 2022

Purpose
Vertical electrical sounding (VES) and Rayleigh wave exploration are widely used in the exploration of near-surface structure, but both have limitations. This study aims to make full use of the advantages of the two methods, reduce the multiple solutions of single inversion and improve the accuracy of the inversion. Thus, a nonlinear joint inversion method of VES and Rayleigh wave exploration based on improved differential evolution (DE) algorithm was proposed.

Design/methodology/approach
Based on the DE algorithm, a new initialization strategy was proposed. Then, taking AK-type with high-velocity interlayer model and HA-type with low-velocity interlayer model near the surface as examples, the inversion results of different methods were compared and analyzed. Then, the proposed method was applied to the field data in Chengde, Hebei Province, China. The stratum structure was accurately depicted and verified by drilling.

Findings
The synthetic data and field data results showed that the joint inversion of VES and Rayleigh wave data based on the improved DE algorithm can effectively improve the interpretation accuracy of the single-method inversion and had strong stability and large generalizable ability in near-surface engineering problems.

Originality/value
A joint inversion method of VES and Rayleigh wave data based on improved DE algorithm is proposed, which can improve the accuracy of single-method inversion.
Community long-term care services in Taiwan: a qualitative study based on provider’s perspectives
Authors: Wang Yi-Fen , Lee Ya-Hui , Lu Jing-Yi 
Published: December 2022

Purpose
This qualitative study aims to explore the experiences of Taiwan’s community-based long-term care service stations.

Design/methodology/approach
Semi-structured interviews were conducted with eight managers selected from stations located in the counties with the highest proportion of elderly people.

Findings
The results are as follows: the main services offered by the stations include health promotion activities, congregate meal programs, respite care and making house calls; government subsidies constitute a major proportion of the service stations’ funds, followed by user payments and external donations; the adversities encountered include frequent policy revisions, the dwellers’ reluctance to participate in the activities, manpower shortages and subpar service quality; and the effects of the stations on the community include achieving aging in place, providing more options for life after retirement, mitigating caregivers’ burden, expanding the elderly’s social networks and strengthening their health literacy.

Originality/value
The results of this research can understand the benefits and difficulties of Tier C service centers in Taiwan. Also, the practical experiences provide some suggestions for policies and training. Future studies can focus on establishing systematized training programs and standardizing the service personnel’s competence.
Revealing oxidative pentose metabolism in new Pseudomonas putida isolates
Authors: Park Mee‐Rye , Gauttam Rahul , Fong Bonnie , Chen Yan , Lim Hyun Gyu , Feist Adam M. , Mukhopadhyay Aindrila , Petzold Christopher J. , Simmons Blake A. , Singer Steven W. 
Published: December 2022

AbstractThe Pseudomonas putida group in the Gammaproteobacteria has been intensively studied for bioremediation and plant growth promotion. Members of this group have recently emerged as promising hosts to convert intermediates derived from plant biomass to biofuels and biochemicals. However, most strains of P. putida cannot metabolize pentose sugars derived from hemicellulose. Here, we describe three isolates that provide a broader view of the pentose sugar catabolism in the P. putida group. One of these isolates clusters with the well‐characterized P. alloputida KT2440 (Strain BP6); the second isolate clustered with plant growth‐promoting strain P. putida W619 (Strain M2), while the third isolate represents a new species in the group (Strain BP8). Each of these isolates possessed homologous genes for oxidative xylose catabolism (xylDXA) and a potential xylonate transporter. Strain M2 grew on arabinose and had genes for oxidative arabinose catabolism (araDXA). A CRISPR interference (CRISPRi) system was developed for strain M2 and identified conditionally essential genes for xylose growth. A glucose dehydrogenase was found to be responsible for initial oxidation of xylose and arabinose in strain M2. These isolates have illuminated inherent diversity in pentose catabolism in the P. putida group and may provide alternative hosts for biomass conversion.
Therapeutic apheresis in sepsis
Authors: Klinkmann Gerd , Altrichter Jens , Reuter Daniel A. , Mitzner Steffen 
Published: December 2022

AbstractSepsis is a leading cause of morbidity and mortality worldwide. Dysregulated immune response to infection is a hallmark of sepsis, leading to life‐threatening organ dysfunction or even death. Advancing knowledge of the complex pathophysiological mechanisms has been a strong impetus for the development of therapeutic strategies aimed at rebalancing the immune response by modulating the excess of both pro‐ and anti‐inflammatory mediators. There is a wealth of preclinical data suggesting clinical benefits of various extracorporeal techniques in an attempt to modulate the exaggerated host inflammatory response. However, the evidence base is often weak. Owing to both an advancing comprehension of the pathophysiology and the increased quality of clinical trials, progress has been made in establishing extracorporeal therapies as part of the general therapeutic canon in sepsis. We aim for a comprehensive overview of the technical aspects and clinical applications in the context of the latest evidence concerning these techniques.
Re‐examining the water affordability: A comparison of alternative measures
Authors: Nemati Mehdi , Schwabe Kurt 
Published: December 2022

AbstractWater affordability is determined by the percentage of income households that must allocate to municipal water services, while factoring in essential or basic needs water use. With the rise in water prices reported in most areas of the country along with somewhat stagnant income growth—a combination that suggests ceteris paribus—more of a household's disposable income is being spent on water services. This paper adds to the discussion in three ways. First, given the lack of a consistent definition for “affordability” and the subjective connotation associated with such a term, we develop and compare five different water expenditure ratios, including two different measures of water for essential needs, as well as measures for indoor, efficient, and actual water use. Second, because of the granularity of our data, we illustrate how such “affordability” measures can vary significantly within a water district and thus highlight how using district‐ or county‐level income measures can mask the degree to which affordability is an issue for households living in low‐income block groups. Our results indicate that the choice of income measure and type of water service use can influence affordability measures substantially.
Real‐world adjuvant chemotherapy treatment patterns and outcomes over time for resected stage II and III colorectal cancer
Authors: To Yat Hang , Degeling Koen , McCoy Melanie , Wong Rachel , Jones Ian , Dunn Catherine , Hong Wei , Loft Matthew , Gibbs Peter , Tie Jeanne 
Published: December 2022

AbstractBackgroundThe administration of adjuvant chemotherapy (AC) to colorectal cancer (CRC) patients in Australia and impact of recent trial data has not been well reported. We aim to evaluate temporal trends in AC treatment and outcomes in real‐world Australian patients.MethodsCRC patients were analyzed from 13 hospitals, stratified by stage (II or III) and three 5‐year time periods (A: 2005–2009, B: 2010–2014, C: 2015–2019). Stage III was further stratified as pre‐ and post publication of the International Duration Evaluation of Adjuvant Therapy (IDEA) collaboration (March 2018). AC prescription, time‐to‐recurrence (TTR), and overall survival (OS) was compared across the time periods.ResultsOf 3977 identified patients, 1148 (stage II: 640, stage III: 508), 1525 (856 vs. 669), and 1304 (669 vs. 635) were diagnosed in Period A, B, and C, respectively. Fewer patients in Period C received AC compared to Period B in stage II (10% vs. 15%, p <.01) and III (70% vs. 79%, p <.01). Post‐IDEA, the proportion of patients receiving ≤3 months of oxaliplatin‐based AC increased (45% vs. 13%, p <.01). The proportion of patients who remained recurrence free at 3 years was similar between time periods in stage II (A: 89% vs. B: 88% vs. C: 90%, p = .53) and stage III (72% vs. 76% vs. 72%, p = .08). OS significantly improved for stage II (80%–85%, p = .04) and stage III (69%–77%, <.01) from period A to B.ConclusionAC use has moderately decreased over time with no impact on recurrence rates. Improved survival in more recent years despite similar recurrence rates may be related to improved baseline staging, better postrecurrence treatment, and reduced noncancer‐related mortality.
Use of oral contrast for CT scanning and time to diagnosis and treatment of acute appendicitis
Authors: Wright Melissa , Giddings Hugh , Rahman Bayzidur , Lord Reginald V. 
Published: December 2022

AbstractBackgroundThe aim of this study was to investigate whether there is a delay in treatment for patients having pre‐operative CT imaging with both intravenous and oral contrast (CTIVO) compared to intravenous contrast alone (CTIV).MethodsA retrospective review of patients who underwent emergency appendicectomy at a single hospital during a two‐year period (1/1/2019–31/12/2020) was performed. Demographic details, imaging timing/modality; biochemical markers; American Society of Anaesthesiologists (ASA) physical status classification, anaesthetic induction time; operative report findings; histopathology, peri‐operative complications, admission/discharge times were recorded. The Sunshine Appendicitis Grading System (SAGS) score was used for severity of appendicitis.ResultsPre‐operative CT was performed in 294 patients; CTIVO: 159 (54%), CTIV: 135 (46%). Both groups were comparable for age, sex, ASA status and inflammatory markers. The median time from CT request to scanning was longer with CTIVO (CTIVO: 170 min, CTIV: 65 min, P < 0.0001). The median time from CT request to induction of anaesthesia was also longer with CTIVO (CTIVO: 780 minutes, CTIV: 406 min, P < 0.0001). A delay to theatre was not significantly associated with severity of appendicitis (SAGS score). The diagnostic accuracy was not reduced in the CTIV group compared to the CTIVO group.ConclusionCTIVO scans significantly delay CT diagnosis and surgical treatment of appendicitis compared to CTIV. Omitting oral contrast does not result in a reduction in diagnostic accuracy for appendicitis.
Regret in organisational life: An overview and research agenda
Authors: Budjanovcanin Alexandra , Rodrigues Ricardo , Guest David 
Published: December 2022

AbstractRegret is a remarkably common occurrence and a fundamental part of life. Defined as ‘the emotion that we experience when realising or imagining that our current situation would have been better, if only we had decided differently’, regret comes along with unpleasant feelings and a wish to undo one's present circumstance. Characterised by self‐blame for a poorly made decision, regret materialises following a comparison with a perceived superior alternative outcome, otherwise known as upward counterfactual thinking. Because it originates from this cognitive process, academic analysis of regret developed alongside the scholarship on counterfactual thinking, which burgeoned from the 1980s. However, in the work domain, the study of regret has remained elusive. In the following, we provide an overview of the concept's scholarly study, both more generally and then specifically in work and organisational study. After introducing the articles in this special section, we outline some further avenues for scholarly work on regret in the context of work and organisations.
Realigning individual behavior with societal values: The role of planning in injunctive‐norm interventions aimed at increasing voter turnout
Authors: French Bourgeois Laura , de la Sablonnière Roxane 
Published: December 2022

AbstractVoting is highly valued in democratic societies. However, in recent years there has been a marked decline in voting. To realign voting behavior with democratic values, we turn to the study of injunctive‐norm interventions. These interventions advance that by making injunctive norms, the norms representing collective values, salient to a targeted group of individuals, individuals will likely conform to the promoted norm. However, studies testing the effectiveness of injunctive‐norm interventions have produced mixed results. We hypothesize that individuals with few plans to vote are those who will be most influenced by these interventions. Individuals with few plans should be more receptive to normative influence because they do not have preconceived commitments about how to engage with voting. Study 1 (N = 141) shows that injunctive‐norm interventions influence the voting behavior of those with few plans about voting. Studies 2 (N = 152) and 3 (N = 195) bring forth evidence that this influence is also present when the salient injunctive norms are from close meaningful groups, such as family and friends.
Intergroup conflict and national identity: The role of exposure to verbal assault, media influences, and desire for self‐reliance
Authors: Amin Azzam , Abdelrahman Mohamed , Hasan Youssef , Van Assche Jasper 
Published: December 2022

AbstractThis study examined the roles of perceived influence of the media, exposure to verbal assault, and desire for self‐reliance on national identity. Using an online self‐reported questionnaire from Qatari college students (N = 293). Mediation analysis revealed that both perceived media influence and desire for self‐reliance fully mediated the effects of exposure to verbal assault on national identity. The findings support the efficacy of strategies which targeted the development and implementation of media and economic programs fostering the construction and/or strengthening of a sense of national identity in Qatar during the Gulf crisis.
Bone morphogenetic protein signaling is a possible therapeutic target in gynecologic cancer
Authors: Fukuda Tomohiko , Suzuki Eri , Fukuda Risa 
Published: December 2022

AbstractBone morphogenetic proteins (BMPs) belong to the transforming growth factor β (TGFβ) superfamily. BMPs play crucial roles in embryogenesis and bone remodeling. Recently, BMP signaling has been found to have diverse effects on different types of tumors. In this review, we summarized the effects of BMP signaling on gynecologic cancer. BMP signaling has tumor‐promoting effects on ovarian cancer (OC) and endometrial cancer (EC), whereas it has tumor‐suppressing effects on uterine cervical cancer (UCC). Interestingly, EC has frequent gain‐of‐function mutations in ACVR1, encoding one of the type I BMP receptors, which are also observed in fibrodysplasia ossificans progressiva and diffuse intrinsic pontine glioma. Little is known about the relationship between BMP signaling and other gynecologic cancers. Tumor‐promoting effects of BMP signaling in OC and EC are dependent on the promotion of cancer stemness and epithelial–mesenchymal transition (EMT). In accordance, BMP receptor kinase inhibitors suppress the cell growth and migration of OC and EC. Since both cancer stemness and EMT are associated with chemoresistance, BMP signaling activation might also be an important mechanism by which OC and EC patients acquire chemoresistance. Therefore, BMP inhibitors are promising for OC and EC patients even if they become resistant to standard chemotherapy. In contrast, BMP signaling inhibits UCC growth in vitro. However, the in vivo effects of BMP signaling have not been elucidated in UCC. In conclusion, BMP signaling has a variety of functions, depending on the types of gynecologic cancer. Therefore, targeting BMP signaling should improve the treatment of patients with gynecologic cancer.
Netrin‐1 upregulates GPX4 and prevents ferroptosis after traumatic brain injury via the UNC5B/Nrf2 signaling pathway
Authors: Zhang Yuanda , Lan Jin , Zhao Dongxu , Ruan Cijie , Zhou Jue , Tan Haoyuan , Bao Yinghui 
Published: December 2022

AbstractAimWe aimed to investigate the regulatory role of Netrin‐1 (NTN1) in ferroptosis after traumatic brain injury (TBI) in mice.MethodsWe assessed the expression pattern of NTN1 by RT–PCR, western blot, and immunofluorescence after establishing the TBI model in mice. After treatment with NTN1 shRNA or recombinant NTN1, we determined the biochemical and morphological changes associated with ferroptosis and netrin‐1‐related pathways. We used Nissl staining to assess lesion volume and Morris water maze and beam‐walking test to evaluate ethological manifestation.ResultsThe mRNA and protein levels of NTN1 were upregulated after TBI. The application of NTN1 shRNA increased the number of FJB positive cells, malondialdehyde (MDA), and reactive oxygen species (ROSs) levels. However, the application of NTN1 recombinant had the opposite effect. Furthermore, knockdown or inhibition of GPX4, Nrf2, and UNC5B counteracted the effects of NTN1 recombinant. Intravenous injection of NTN1 recombinant reduced neuronal loss after CCI and improved motor and cognitive function.ConclusionNTN1 had a neuroprotective effect after TBI and inhibited ferroptosis via activating the UNC5B/Nrf2 pathway. These findings may provide potential therapeutic strategies for TBI.
Developmental switch from morphological replication to compensatory growth for salamander lung regeneration
Authors: Yin Binxu , Zhang Kun , Du Xinge , Cai Hao , Ye Tingting , Wang Heng 
Published: December 2022

AbstractSalamanders possess a pair of lungs for active air breathing, but the lung respiration is fully operational only during the late stage of development, particularly after metamorphosis. Larval salamanders mainly exchange air through the gills and skin, thus sparing the developing lungs. Salamanders can repair their lungs after injury, but a comparative analysis of regenerative responses between the lungs of young and adult animals is lacking. In this study, lung resections were performed in both larval and adult newts (Pleurodeles waltl). The cellular dynamics, tissue morphology and organ function during lung regeneration were examined and the Yap mutants were produced with CRISPR tools. We found that salamander switches the regenerative strategies from morphological replication through the blastema formation to compensatory growth via resident epithelial cells proliferation upon pulmonary resection injury as it transitions beyond metamorphosis. The larval animals achieve lung regeneration by forming a transient blastema‐like structure and regrowing full‐sized developing lungs, albeit unventilated. The adults repair injured lungs via massive proliferating epithelial cells and by expanding the existing alveolar epithelium without neo‐alveolarization. Yap signalling promotes epithelial cell proliferation and prevents epithelial‐to‐mesenchymal transition to restore functional respiration. The salamanders have evolved distinct regenerative strategies for lung repair during different phases of life. Our results demonstrate a novel strategy for functional lung recovery by inducing epithelial cell proliferation to strengthen the remaining alveoli without rebuilding new alveoli.
Illicit drug use among lesbian, gay, bisexual, pansexual, trans and gender diverse, queer and asexual young people in Australia: Intersections and associated outcomes
Authors: Hill Adam O. , Amos Natalie , Lyons Anthony , Jones Jami , McGowan Ivy , Carman Marina , Bourne Adam 
Published: December 2022

AbstractIntroductionHigh rates of illicit drug use have been reported among gay and bisexual young men, however limited research has examined patterns of drug use among the broader population of lesbian, pansexual, trans and gender diverse, asexual and queer (LGBTQA) young people. We examined factors associated with illicit drug use in the past 6 months and lifetime experiences of self‐reported concern with drug use among LGBTQA youth in Australia.MethodsA cross‐sectional survey was conducted involving 6418 LGBTQA participants aged 14–21 years, 5914 of whom provided information relating to their use of illicit drugs. Multivariable logistic regressions examined demographic factors and life experiences associated with drug use in the past 6 months and lifetime experiences of self‐reported concern with drug use.ResultsOverall, 26.4% of participants aged 14–17 and 41.9% aged 18–21 reported any drug use in the past 6 months, of whom 23.5% had ever been concerned about their drug use. Cannabis use was most commonly reported (28.3%), followed by ecstasy/MDMA (7.1%), antidepressants (5.6%) and LSD (3.5%). Higher odds of drug use were reported among cisgender men and those who had experienced homelessness or sexual harassment in the past 12 months. Higher odds of self‐identified concern about drug use were observed among participants reporting challenging life experiences.Discussion and ConclusionsRates of illicit drug use among LGBTQA young people in this study were considerably higher than those observed in general population youth studies in Australia and were further elevated among those who had experienced LGBTQA‐related prejudice or harassment, or homelessness.
Bone marrow expression of CD68/CD163 macrophages, IL‐17 and FOXP3 cells in aplastic anemia and their relation to prognosis
Authors: Vaht Krista , Brenner Jonas , Ednersson Susanne Bram , Ljungman Per , Brune Mats , Andersson Per‐Ola 
Published: December 2022

AbstractObjectivesThe primary mechanism for bone marrow failure in aplastic anemia (AA) is autoimmune hematopoietic stem cell destruction. AA can be cured with antithymocyte globulin (ATG) treatment, and some smaller studies have indicated that the number of regulatory T cells (Tregs) may be predictive of response. Additionally, AA patients appear to have elevated numbers of Th17 cells and bone marrow macrophages, but outcome data are missing.MethodsWe performed immunohistochemistry on bone marrow biopsies from 121 ATG‐treated AA patients and 14 healthy controls, using antibodies against FOXP3 (for Tregs), IL‐17 (for Th17), CD68 (for pan‐macrophages) and CD163 (for M2 type macrophages) to study their possible relation to ATG response and AA prognosis.ResultsAA patients had significantly fewer Tregs and Th17 cells but significantly more macrophages compared with controls. Treg, Th17 and pan‐macrophage cell numbers were not associated with ATG response or differences in survival. Patients with higher levels of M2 macrophages had improved 5‐year overall survival: 79.6% versus 57.4% (p = .017), and this benefit was primarily seen in AA patients with non‐severe disease.ConclusionsWe found that Treg and Th17 cell numbers did not predict ATG response or survival, whereas M2 macrophages may be associated with improved survival.