bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility of the pattern‐based approach using BIOCHIP‐indirect immunofluorescence in the evaluation of subepidermal bullous disorders
Authors: Venkataswamy Chaitra , Vinayagam Nithyanandam , Shanmugasundaram Sakthisankari , Rai Reena 
Published: November 2022

AbstractBackgroundSubepidermal bullous disorders (SEBD) are a heterogeneous group of vesiculobullous diseases because of antibody‐mediated destruction of proteins of the dermo‐epidermal junction. Direct immunofluorescence (DIF) is the gold standard for diagnosis. BIOCHIP‐indirect immunofluorescence (IIF) is a novel serological test that combines multiple target antigens in a single field. The present study aimed to evaluate the utility of the pattern‐based approach in BIOCHIP‐IIF for the diagnosis of SEBD.MethodsSeventy cases of BIOCHIP‐IIF that showed clinical, histopathological, and/or DIF features favoring SEBD were included in the study. The interpretation in the BIOCHIP was categorized into one of the following patterns. Pattern I: basement membrane zone (BMZ) staining in monkey esophagus (ME), primate salt‐split skin (SSS)‐roof staining, BP180+ and/or BP230+; Pattern II: roof staining in SSS, BP180– and BP230– with or without BMZ staining in ME; Pattern III: floor staining in SSS, BP180– and BP230–; and pattern IV: negative in SSS and other substrates. The findings were correlated with histopathology and/or DIF.ResultsFifty (71.5%) cases showed pattern I or the typical bullous pemphigoid (BP) pattern. Eight (11.4%) cases showed pattern II. Patterns III and IV were observed in seven (10%) and five (7.1%) cases, respectively. BP was the most common diagnosis in patterns I and II, while anti‐p200 pemphigoid was most common in pattern III, as confirmed by immunoblotting. The sensitivity of pattern I in the diagnosis of BP was 96%.ConclusionBIOCHIP‐IIF showed a good correlation with DIF and histopathology in the diagnosis of SEBD. This can be used as a first‐line investigation in case of bullous disorders.
Increase of atypical fibroxanthoma and pleomorphic dermal sarcoma: a retrospective analysis of four German skin cancer centers
Authors: Kuntz Thomas , Siebdrath Julian , Hofmann Silke C. , Baltaci Mehmet , Schaller Jörg , Hellmich Martin , von Goltzheim Luise Stach , Assaf Chalid , Oellig Frank , Michalowitz Alena‐Lioba , Helbig Doris , Kreuter Alexander 
Published: November 2022

SummaryBackground and objectivesIn recent years, considerable insight has been gained into the pathogenesis, diagnosis and treatment of cutaneous sarcomas, including atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS). Both entities have shown increasing incidence rates in the last decade. This study was initiated to evaluate how these new insights impact the number of diagnoses of AFX/PDS compared to other cutaneous sarcoma entities.Patients and methodsIn a retrospective study of four German skin cancer centers, all histopathological reports of cutaneous sarcomas (AFX, PDS, dermatofibrosarcoma protuberans, cutaneous leiomyosarcoma, angiosarcoma, and Kaposi sarcoma) confirmed by board‐certified dermatopathologists were analyzed during a time‐period of seven years (2013–2019). Additionally, utilization of immunohistochemical markers (including pan‐cytokeratin, S100, desmin, CD34, CD10, procollagen‐1, CD99, CD14, and CD68) as an adjunct to diagnose AFX/PDS was recorded.ResultsOverall, 255 cutaneous sarcomas were included in the present study. The diagnosis of a cutaneous sarcoma has consequently risen from 2013 to 2019 (from 16 to 52 annual cases). The results of AFX/PDS revealed 4.6 times more diagnoses in 2019 than in 2013. Atypical fibroxanthoma represented the most common subtype, displaying 49.3 % of all diagnosed cutaneous sarcomas. Additionally, the increase of AFX/PDS was linked to the use of immunohistochemistry, with specific immunohistochemical markers used in 57.1 % of cases in 2013 compared to 100 % in 2019.ConclusionsThis retrospective study of four German skin cancer centers demonstrates a substantial rise of AFX/PDS, possibly due to recently established diagnostic and terminology standards. This rise is probably linked to increased utilization of specific immunohistochemical markers. Atypical fibroxanthoma/PDS may be more common than previously thought and seems to represent the most frequent cutaneous sarcoma subtype.
Uninformed voters with (im)precise expectations: Explaining political budget cycle puzzles
Authors: Crombach Lamar , Bohn Frank 
Published: November 2022

AbstractGovernments try to improve re‐election chances by using fiscal instruments; they can shift voters' expectations of government competence because some voters are impaired by uninformedness. We argue that uninformed voters may also be impaired in another way which has not been considered in the literature, namely that uninformed voters are uncertain about the precision of that expected competence. Analytically, we show that political budget cycles (PBCs) are only produced when we have many uninformed voters and their expected competence of the government is fairly uncertain; or with few uninformed voters and certain expectations. This could explain two empirical puzzles on why we sometimes find and sometimes not (i) PBCs in developed and democratic countries with strong institutions, and (ii) that press freedom exacerbates PBCs. In a panel of 70 countries (1986–2015) we find empirical support for these findings. Results are robust to alternative specifications and explanations like fiscal rules, corruption and expected downturns.
Species traits help explain butterfly habitat use in a tropical forest
Authors: Jambhekar Ravi , Driscoll Don A. 
Published: November 2022

Abstract
When species can access all parts of the landscape, species‐sorting metacommunity theory predicts that community composition depends on habitat choice and interactions with other species and the environment. These filtering processes can also depend on species' traits.
The authors investigated how traits mediate a species‐sorting process in determining butterfly community composition in a naturally patchy landscape in the tropical Western Ghats, India. The authors asked, do traits mediate access to certain habitats and does seasonality affect these patterns? The authors surveyed 56 habitat patches in three habitat types: laterite plateau grasslands, ridge grassland, and moist‐deciduous forest, in a 65‐km2 landscape.
Non‐palatable butterflies showed similar occurrences across seasons and habitats, but palatable butterflies were less commonly encountered in open habitats in the dry season. Polyphagous butterflies occurred infrequently in the dry season in laterite habitats, potentially indicating emigration or diapause patterns are linked to diet breadth.
All species were present in all habitats, implying dispersal does not limit access to different habitat patches, consistent with the species‐sorting metacommunity concept. Nevertheless, butterfly occurrence was strongly influenced by the interaction of mobility and habitat type with sedentary species occurring less often in low‐resource open laterite patches than mobile species.
Species sorting is typically regarded as occurring directly through environmental filters, but here the authors suggest that the environmental filter acts through movement limitations. Studies integrating landscape heterogeneity and species characteristics will help us better understand metacommunities and species distributions in nature.
White clover (Trifolium repens) population dynamics are partly dependent on timing of seminal taproot death
Authors: Janssen Pedro W. L. , Hoekstra Nyncke J. , van der Schoot Jan Rinze , van Eekeren Nick 
Published: November 2022

AbstractThe expanded usage of white clover has increased the importance of understanding white clover dynamics in pastures. It is assumed that clover plants have a higher tolerance for moisture and nutrient deficiencies when the taproot is still present. Therefore, the survival of the seminal taproot can influence the dynamics of clover. Past breeding efforts in countries like New Zealand have focussed on increasing the taproot longevity through hybridisation with a close relative of white clover. However, there is no direct evidence whether increased survival of the taproot results in increased performance of white clover. In this study, we aimed to (i) assess the relationship between taproot volume and taproot survival, and (ii) whether the timing of death of the seminal taproot influences the population dynamics of white clover varieties. In a two‐year field experiment with 18 white clover varieties grown in monoculture and in mixture with Lolium perenne L, the taproot characteristics and population dynamics were studied. It was shown that taproot volume was positively correlated to both leaf size and taproot presence during autumn 2017, 1 year after sowing. The combination of the timing of death of the seminal tap root and the development of stolons seems to play a more important role in increasing the persistence of white clover than the absolute survival of the seminal taproot. Future research should focus on understanding the transition from a taprooted white clover to a stolonous white clover plant in relation to specific weather events such as winter frost conditions.
Queering the pandemic at work, a fictocritical tale
Authors: Lescoat Pierre 
Published: November 2022

AbstractThis short paper blurs fiction and theoretical analysis to describe how a non‐binary subject experiences the pandemic. The story focuses on one day and three moments: before work, during work, and after work. The tale illustrates how living at the margins of heteronormativity enacts new forms of subjectivities. It also contributes to the writing differently movement by mixing fiction, theoretical insights, and other forms of writing. This is what I call a fictocritical text, mixing genres and genders to encourage critical thinking.
Improving bleeding disorder treatment log adherence: An application of the information‐motivation‐behavioral skills model
Authors: Littner Lisa , Thomas Evan , Doyle Julie , Hendrickson Julie , Adkins Susan , Mooney Laura , Tarango Cristina 
Published: November 2022

AbstractIntroductionFor people with severe bleeding disorders (PwBD) who are prescribed home treatment, treatment logs are an important part of the management of their care. Treatment logs provide a clinical picture of the home treatment regimen and can serve as a communication tool between the medical team and the person with a bleeding disorder. Most importantly, treatment logs allow for the adjustment of the treatment dose and frequency to prevent bleeding episodes. Yet, a large number of PwBD do not complete treatment logs.AimsWe aimed to develop and implement interventions to increase adherence rates of treatment log completion in PwBD on a home treatment regimen by at least 20% over 2 years.MethodsWe conducted a quality improvement initiative from 2019–2022 involving developing and implementing interventions that were guided by the application of the Information‐Motivation‐Behavioural Skills Model. Examples of interventions included: the development of educational materials on the different methods of log completion and interactive discussions that involved a patient‐driven decision of selecting a treatment log method. Data on the implementation of the theoretically‐based interventions as well as outcome data on the success of treatment log completion was reviewed monthly.ResultsFollowing the application of the Information‐Motivation‐Behavioural Skills Model on the designed and implemented interventions, there was a 20% increase in individuals’ adherence with treatment logs completion (N = 68).ConclusionTreatment logs are an important piece of a PwBDs’ prescribed home treatment regimen. Quality improvement interventions promoted increased treatment log adherence for PwBDs'prescribed prophylactic home treatment.
Recurrent RET fusions in fibrosarcoma‐like neoplasms in adult viscera: expanding the clinicopathological and genetic spectrum
Authors: Zhao Ming , Yin Xiaona , He Huiying , Xia Qiuyuan , Ru Guoqing 
Published: November 2022

AimsRET‐fused mesenchymal neoplasms mostly affect the soft tissue of paediatric patients. Given their responsiveness to selective RET inhibitors, it remains critical to identify those extraordinary cases occurring in the visceral organs of adults. In this study, we report three RET‐rearranged spindle‐cell tumours occurring in the visceral organs of adults.Methods and ResultsClinicopathological features were assessed and partner agnostic targeted next‐generation sequencing on clinically validated platforms were performed. The patients were 18, 53, and 55 years old and included one male and two females. The tumours were located in the kidney (case 1), small intestine (case 2), and ureter (case 3), with maximum diameters of 14, 5, and 1 cm, respectively. Histologically, all tumours displayed a morphological spectrum typical of fibrosarcoma, including moderately to highly cellular, nonpleomorphic, ovoid to spindle‐shaped cells arranged in long fascicles or haphazardly within collagenised to myxohyaline stroma. Foci of irregular alveolar oedema‐like structures and areas with microcystic and reticular arrangements were identified in the renal tumour. Staghorn‐type vessels and foci of band‐like stromal hyalinisation were observed in the small intestine tumour. Cases 1 and 2 were high‐grade and pursed a highly aggressive clinical course, while case 3 was of intermediate grade with no tumour recurrence or metastasis 14 years after surgery. All three tumours expressed CD34, which was coexpressed with S100 protein in cases 2 and 3. Molecular genetic testing revealed PRKAR1A::RET, KIF5B::RET, and SPECC1L::RET in‐frame gene fusions.ConclusionOur study expands the clinicopathological and genetic spectrum of mesenchymal neoplasms associated with RET fusions.
Thick description and systems thinking: Reiterating the importance of a biopsychosocial approach to mental health
Authors: Fanali Annibale , Giorgi Franco , Tramonti Francesco 
Published: November 2022

AbstractStudy AimsThe article aims at reiterating the importance of a biopsychosocial approach to mental health, taking stock of the critiques that have been raised and moving forward throughout a reconsideration of the theoretical background of systems thinking and emphasizing the relevance of the concept of thick description for the promotion of an adequate reflection on methodology and case formulation.Literature ReviewIt is our opinion that the biopsychosocial approach is still a powerful framework for making sense of the growing data collected in the different fields related to mental health and for designing proper treatment plans. A crucial challenge for mental health is that of surpassing the dichotomies and ideological disputes that still contaminate the field with detrimental effects on the advancement of knowledge and on the integration and continuity of different kind of interventions.ConclusionsThe time is ripe for building bridges among neuroscience, humanities and social sciences, and this can only happen within the umbrella of a biopsychosocial perspective reinstated into its systems thinking background.
Botulinum toxin for cosmetic treatments in young adults: An evidence‐based review and survey on current practice among aesthetic practitioners
Authors: Michon Alain 
Published: November 2022

AbstractBackgroundBotulinum toxin A (BoNTA) treatments are popular worldwide. Young adults, less than 41 years of age, are an important cohort of patients seen in practice, and the optimal dosage of BoNTA in this age group remains poorly defined.Aims and ObjectiveTo determine the optimal dosing of BoNTA across different age‐matched cohorts by reviewing the literature and to evaluate current BoNTA practices among aesthetic practitioners when treating younger versus older adults.MethodsAn evidence‐based literature review was performed to evaluate the current evidence on BoNTA injections for cosmetic indications in millennials (born between 1981 and 1996) and young adults. A cross‐sectional online survey was distributed to aesthetic practitioners to assess their current practice with BoNTA.ResultsThere is a paucity of high‐quality research on BoNT in millennials. Our literature review suggests different patterns of practice when treating younger adults. Specifically, our survey revealed that: (1) younger adults are receiving, on average, fewer units of BoNTA at the glabella, forehead, and crow's feet, (2) younger toxin‐naïve patients are also afraid to look frozen or unnatural, and (3) wrinkles prevention was the most common reason for seeking treatment in younger patients.ConclusionThe literature review supports the efficacy of BoNTA for correcting wrinkles in millennials. Our findings provide further insight into the dosing pattern of cosmetic BoNTA and motivating factors for seeking treatments in young adults. This valuable information will help practitioners with treatment planning when seeing patients from different age cohorts. An individualized approach and a lower dosage of BoNTA in toxin‐naïve younger adults are recommended.
Effect of ritodrine hydrochloride infusion on fetal movement with the use of a fetal movement acceleration measurement recorder (FMAM recorder)
Authors: Yonaga Yuriko , Ryo Eiji , Yatsuki Keita , Kamata Hideo , Ito Akihiko 
Published: November 2022

AbstractAimTo investigate the effect of ritodrine hydrochloride infusion on fetal movement.MethodWe gathered 20 pregnant women who received ritodrine hydrochloride infusion as the treated group, and 147 pregnant women who did not as the control group. All women recorded gross fetal movement with the fetal movement acceleration measurement recorder after 28 gestational weeks. The record was divided into epochs of 10 s, and the ratio of movement‐positive epochs to all epochs was calculated as the fetal movement index. Furthermore, the mean duration and the mean number per hour of no‐fetal movement period, where the fetus did not move for 5 min or more, were calculated as the indexes of no‐fetal movement. All indexes were compared between the two groups at 28–31 and 32–35 gestational weeks.ResultsThe fetal movement indexes (%) were 17.29 ± 7.46 (mean ± SD) in the control group and 13.65 ± 7.13 in the treated group at 28–31 weeks (p = 0.139). At 32–35 weeks, they were 14.55 ± 6.43 and 18.50 ± 5.33, respectively (p = 0.03). Similarly, the no‐fetal movement indexes (min, times/h) were 15.03 ± 10.99 and 1.61 ± 0.88, and 18.70 ± 15.80 and 1.75 ± 0.96 (p = 0.824, and 0.673) at 28–31 weeks. At 32–35 weeks, they were 18.13 ± 10.88 and 1.95 ± 0.97, and 9.20 ± 5.51 and 1.14 ± 0.71, respectively (p = 0.003, and 0.003).ConclusionRitodrine hydrochloride infusion increased the fetal movement and decreased the no‐fetal movement period at 32–35 weeks.
Periodontal ligament‐associated protein‐1 engages in teeth overeruption and periodontal fiber disorder following occlusal hypofunction
Authors: Chen Yilin , Luo Mengqi , Xie Yaxin , Xing Lu , Han Xianglong , Tian Ye 
Published: November 2022

AbstractBackground and ObjectiveTeeth overeruption is a problem of clinical significance, but the underlying mechanism how changes in external occlusal force convert to the periodontium remodeling signals has been a largely under explored domain. And recently, periodontal ligament‐associated protein‐1 (PLAP‐1)/asporin was found to play a pivotal role in maintaining periodontal homeostasis. The aim of this study was to explore the function of PLAP‐1 in the periodontally hypofunctional tissue turnover.MethodsAfter extracting left maxillary molars in mice, the left and right mandibular molars were distributed into hypofunction group (HG) and control group (CG), respectively. Mice were sacrificed for radiographic, histological, and molecular biological analyses after 1, 4 and 12 weeks. In vitro, dynamic compression was applied using Flexcell FX‐5000 Compression System to simulate intermittent occlusal force. The expression of PLAP1 in loaded and unloaded human periodontal ligament cells (hPDLCs) was compared, and its molecular biological effects were further explored by small interfering RNA (siRNA) targeting PLAP1.ResultsIn vivo, fiber disorder in periodontal ligament (PDL), bone apposition at furcation regions, and bone resorption in alveolar bone were illustrated in the HG compared with the CG. In addition, PLAP‐1 positive area decreased significantly in PDL following occlusal unloading. In vitro, the loss of compressive loading relatively downregulated PLAP1 expression, which was essential to promote collagen I but inhibit osterix and osteocalcin expression in hPDLCs.ConclusionsPLAP‐1 presumably plays a pivotal role in occlusal force‐regulated periodontal homeostasis by facilitating collagen fiber synthesis in hPDLCs and suppressing excessive osteoblast differentiation, further preventing teeth from overeruption. Further evidence in PLAP‐1 conditional knockout mice is needed.
Baseline ALBI score and early variation of serum AFP predicts outcomes in patients with HCC treated by atezolizumab–bevacizumab
Authors: Campani Claudia , Bamba‐Funck Jessica , Campion Bertille , Sidali Sabrina , Blaise Lorraine , Ganne‐Carrié Nathalie , Demory Alix , Sutter Olivier , Larrey Edouard , Evain Manon , Ghannouchi Haroun , Wagner Mathilde , Marra Fabio , Sutton Angela , Allaire Manon , Nault Jean‐Charles 
Published: November 2022

AbstractBackgroundThe combination of atezolizumab and bevacizumab (AtezoBev) is the current first‐line treatment for patients with hepatocellular carcinoma (HCC). Our aim was to evaluate the prognostic role of alpha‐foetoprotein (AFP) early response and its combination with albumin–bilirubin (ALBI) in these patients.MethodsPatients with HCC under AtezoBev with AFP > 20 ng/ml were included in three centres. The optimal threshold of AFP variation after 3 weeks of treatment was identified for overall survival (OS) and radiological response (RR) using RECIST 1.1 and mRECIST and its ability to predict progression‐free survival (PFS) and OS was tested using univariate and multivariate analysis in derivation and validation cohorts.ResultsSeventy‐five patients with AFP values >20 ng/ml were included. Fifty‐eight patients were male with a median age of 63.5 years; 73% had cirrhosis and HCC stage was classified as BCLC B (18.7%) or C (81.3%). In the derivation cohort (n = 38), a decline in AFP ≥ 20% at 3 weeks (AFP early response) was associated with RR using mRECIST criteria (OR: 13.09 95% CI: 1.44–19.34 p = .02), PFS (HR: 0.42; 95% CI: 0.19–0.93, p = .03) and OS (HR: 0.35; 95% CI: 0.15–0.83, p = .01). AFP early response was confirmed as predictor of RR (p = .02 for mRECIST) and OS (p = .03) in the validation cohort (n= 37). In the whole cohort, the combination of ALBI and AFP early response was significantly associated with OS (p = .046) and PFS (p = .012) with a poor prognosis in patients belonging to the ALBI2‐AFP non‐responders class.ConclusionAFP early response at 3 weeks predicts oncological outcomes in HCC patients treated with AtezoBev and combination with ALBI grade refines prognostic discrimination.