bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH PENGGUNAAN MEDIA PEMBELAJARAN KEARSIPAN DIGITAL TERHADAP KEMAMPUAN MENGELOLA ARSIP SISWA KELAS X-OTKP SMKN MOJOAGUNG
Authors: Rismanto Rico , Pahlevi Triesninda 
Published: May 2022

ABSTRAKRiset ini memiliki tujuan untuk mengetahui apakah terdapat pengaruh penggunaan media pembelajaran kearsipan digital terhadap kemampuan mengelola arsip pada siswa kelas X-OTKP SMK Negeri Mojoagung. Riset ini merupakan riset eksperimen dengan model non-equivalent control grub design yang melibatkan kelas kontrol dan kelas eksperimen. Populasi berjumlah 141 orang dan sampel pada penelitian ini melibatkan 70 orang yang diambil menggunakan teknik random sampling. Beberapa uji yang digunakan dalam penelitian meliputi analisis deskriptif, uji normalitas, uji homogenitas, uji hipotesis, dan N-Gain Score. Hasil riset ini ditunjukkan dengan menggunakan Uji Independent sample t-test dengan hasil thitung (5,507) > ttabel (1,995). Untuk uji N-Gain Score diperoleh nilai sebesar 0,56 yang menujukkan bahwa media pembelajaran kearsipan digital dikategorikan cukup efektif. Sehingga berdasarkan hasil perhitungan Uji Independent Sample t-test dan Uji N-Gain score dapat disimpulkan bahwa H1 diterima.Kata Kunci: Media Pembelajaran, Kearsipan Digital, Kemampuan Mengelola Arsip ABSTRACTThis research aims to find out whether there is an influence on the use of digital archival learning media on the ability to manage archives in students of the X-OTKP class of SMK Negeri Mojoagung. This research is an experimental research with a non-equivalent control grub design model involving control classes and experimental classes. The population was 141 people and the sample in this study involved 70 people taken using random sampling techniques. Some of the tests used in research include descriptive analysis, normality tests, homogenity tests, hypothesis tests, and N-Gain Scores. The results of this research were shown using the Independent sample t-test with the results of tresult (5,507) > ttable (1,995). For the N-Gain Score test, a value of 0.56 was obtained which indicated that digital archival learning media was categorized as quite effective. So based on the results of the Independent Sample t-test and N-Gain Score Test, it can be concluded that H1 is accepted.Keywords: Learning Media, Digital Archives, Ability to Manage Archives
PEMBUATAN ISOLAT PAPAIN DARI GETAH BUAH PEPAYA UNTUK HIDROLISIS PROTEIN PADA PENGEMBANGAN METODE PENAMBAHAN MATERI PRAKTIKUM BIOKIMIA
Authors: Yana Rini , Permatasari Suci 
Published: May 2022

Buah pepaya merupakan buah yang tumbuh didaerah tropis yang rasanya enak dan banyak mengandung vitamin yang dibutuhkan oleh tubuh. Hampir semua bagian tanaman pepaya ini dapat dimanfaatkan seperti daun, bunga, batang dan getahnya. Getah buah pepaya berwarna putih cukup banyak mengandung enzim pemecah protein (proteolitik) yang disebut papain, dimana enzim ini dapat mengkatalis ikatan protein menjadi senyawa-senyawa yang sederhana seperti asam amino. Papain sebagai salah enzim yang mempunyai beberapa kelebihan antara lain lebih stabil terhadap faktor suhu dan pH. mudah didapat, tersedia dalam jumlah yang banyak dan harganya murah. Pembuatan isolat papain dari getah buah pepaya dengan metode pengeringan kabinet menghasilkan bubuk putih enzim papain, dimana uji aktivitas menggunakan metode Walter diperoleh 1,018 U/mL. Papain kering yang diperoleh sebanyak 56 g atau rendemen sebesar 46,7 %, berukuran 100 mesh. berwarna putih dan berbau khas pepaya. Aktivitas enzim papain terjadi pada pH optimum 8,0 dan suhu optimum pada 55 oC, dengan hasil hidrolisis yang memiliki kadar protein tertinggi pada konsentrasi enzim papain 8 %. Penggunaan papain isolat kadar protein tertinggi dicapai sebesar 3,600 mg/ml untuk sampel BSA dan untuk protein serum sebesar 1,178 mg/ml, sedangkan jika digunakan papain pabrikan diperoleh kadar protein tertinggi adalah 2.431 mg/ml untuk sampel BSA dan untuk protein serum sebesar 1.125 mg/ml.Kata kunci : Isolat papain, getah buah pepaya, hidolisis protein.
HUBUNGAN TINGKAT KONSUMSI BAHAN MAKANAN SUMBER ISOFLAVON DAN SERAT DENGAN KADAR HbA1c PASIEN DIABETES MELLITUS TIPE II DI RUMAH SAKIT DR. H. BOB BAZAR LAMPUNG SELATAN
Authors: Laily Wahyu Nur , Wati Desti Ambar , Suci Ayu Riska Nur , Pratiwi Amali Rica 
Published: May 2022

Diabetes mellitus is a metabolic disorder disease characterized by an increase in blood glucose levels due to a decrease in insulin secretion. Factors that can affect the patient's blood sugar level are the level of consumption of isoflavones and fiber. The purpose of this research is to determine the correlation between consumption levels of isoflavones and fiber sources with HbA1c levels in patients with type II diabetes mellitus at Dr. H. Bob Bazar Hospital in South Lampung. This research type is analytic with a cross-sectional approach. The sample in this research amounted to 45 patients with diabetes mellitus at Dr. H. Bob Bazar in South Lampung. The sampling used is purposive sampling. Primary data on the consumption of isoflavones and fiber that have been obtained by interview method with the SQ FFQ questionnaire and examination of HbA1c levels were then analyzed by using the Spearman Rank correlation statistical test. The results showed that there was a correlation between the level of consumption of isoflavone sources of food with HbA1c levels in the patients with type II DM (p-value 0.00) and there was a relationship between the level of consumption of dietary fiber sources with HbA1c levels in patients with type II DM at dr. H. Bob's Bazar (p-value 0.00).
Exploring Nature in the Selected Poems of Derek Walcott and Kaiser Haq: An Ecocritical Approach
Authors: A.S.M. Mahbubur Rahman  , Md. Faisal Haque  , Md. Lutful Arafat  , Rahul Bhattacharya  , Hasi Akter  
Published: May 2022

The main goal of this article is to look into the relationship between nature and man as it is portrayed in the poetry of Derek Walcott and Kaiser Haq, two renowned poets from two distinct realms, namely St. Lucia and Bangladesh, respectively. Taking into consideration the rising level of environmental awareness, both poets have attempted to produce poetry that integrates man with nature. The poetry, particularly nature poetry, of these poets is explored in order to undertake study from an individual viewpoint, but there has yet to be a major examination into a comparative technique by adopting an ecocritical approach. In this study, the researchers attempt to uncover the nature of poetry disguised inside the chosen poems of the legendary poets by examining the creative and aesthetic characteristics of their works. This study examines the interaction between man and the environment via the lens of an ecocritical approach in a comparative manner. In this research, one poem by Kaiser Haq, "Poor Man Eating," and one poem by Derek Walcott, "Map of the New World," are examined from the perspective of environmental awareness. By concentrating on these poems and using an ecocritical perspective, this study attempts to demonstrate how the poet is sensitive to nature and how people are concerned about the environment.
Aplikasi Presensi Siswa Berbasis Web dan Qr-Code pada Pembelajaran Tatap Muka di Sekolah
Authors: Nuraeni Fitri , Setiawan Ridwan , Amal Ridzky Ichlasul 
Published: May 2022

Penggunaan teknologi komputer dalam pengolahan data diperlukan untuk keperluan proses pembelajaran dan administrasi di sekolah. Apalagi disaat pandemi, setiap kegiatan mulai bergantung pada teknologi komputer dan jaringan, yaitu sistem online. Pertengahan tahun 2021, pemerintah sudah mengizinkan kegiatan pembelajaran tatap muka (PTM) di sekolah dengan menerapkan protokol kesehatan. Proses presensi di sekolah masih menggunakan cara ditulis tangan sehingga memakan banyak waktu, sedangkan waktu pembelajaran cukup singkat. Selain itu, presensi manual masih memiliki berbagai kelemahan diantaranya adalah data yang bertumpuk dan data yang rawan hilang. Oleh karena itu, dibuat sebuah aplikasi presensi siswa berbasis web dengan memanfaatkan fitur scan QR-Code untuk menandai kehadiran siswa. Aplikasi Presensi Siswa berbasis web dengan menggunakan QR-Code ini dikemblangkan menggulnakan metodlologi Rational Unified Process (RUP) dengan alat analisis dan desain menggunakan UML, serta menggunakan HTML dan PHP untuk mengkodeannya. Dari penelitian ini dihasilkan aplikasi presensi siswa berbasis web dan QR-Code, dimana aplikasi presensi ini dapat di manfaatkan dalam mengelola presensi siswa pada pembelajaran tatap muka di sekolah. Manfaat dari aplikasi Presensi Siswa Berbasis Web dan QR-Code yaitu untuk mengurangi kontak fisik dan waktu berkumpul dalam ruangan kelas pada saat pandemi sehingga dapat mengurangi resiko penularan virus covid-19 serta membantu proses pelaporan kehadiran siswa untuk proses penilaian.
Influencia del pensamiento computacional en las habilidades cognitivas propias de los métodos de resolución de problemas
Authors: Brugés Romero Augusto Ramiro , Camperos Villamizar Yadira del Pilar 
Published: May 2022

El desarrollo de software se ha convertido en un aspecto fundamental en la formación de ingenieros y se ha establecido como una competencia diferenciadora al momento de acceder al campo laboral; sin embargo, su aprendizaje no es una tarea fácil y muchos estudios apuntan a que el principal inconveniente se encuentra en la debilidad cognitiva de los estudiantes para resolver problemas, lo cual es un problema recurrente en otras áreas de formación, por lo que se hace necesario fortalecer la comprensión, el análisis, la síntesis y la evaluación a nivel general. Desde esta perspectiva, se planteó una investigación con un enfoque cualitativo y diseño fenomenológico, cuyo objetivo principal estuvo en analizar la influencia del pensamiento computacional en el mejoramiento de las habilidades cognitivas propias de los métodos de resolución de problemas. Los informantes de la investigación fueron 10 estudiantes del curso de programación I y II en el periodo 2021-I, y utilizó como técnicas de recolección de información pruebas al iniciar y al finalizar el curso, la observación participante y la entrevista semiestructurada. Los resultados de los instrumentos aplicados evidenciaron que los estudiantes presentan problemas de comprensión e interpretación, así como desconocimiento de conceptos básicos que obstaculizaron el correcto planteamiento de soluciones a los problemas presentados en las pruebas iniciales. En la prueba diagnóstica la mayoría de los estudiantes obtuvieron bajos resultados, lo que indica que existen deficiencias para solucionar problemas, ya que los elementos del pensamiento computacional son aplicados de manera mínima y los aciertos obedecen más a procesos mentales de orden inferior como memoria, observación y comparación. Los resultados de la prueba final y el análisis de los demás instrumentos aplicados muestran que la adquisición de conocimientos sobre programación mejoró las habilidades de abstracción y análisis; aumentaron la creatividad; incluyeron elementos de diseño, planificación y seguimiento; desarrollaron la metacognición, la síntesis y la evaluación. La presente investigación arrojó como resultado que el desarrollo del pensamiento computacional le permite al estudiante mejorar la forma en que resuelve los problemas, adquiriendo habilidades cognitivas y metacognitivas para utilizar nuevos métodos y estrategias que generan alternativas de solución más creativas, ágiles y eficientes. El uso adecuado del conocimiento y los elementos adquiridos en torno al pensamiento computacional y el aprendizaje de la programación, así como la mejora de habilidades asociadas al análisis y la comprensión, permiten optimizar la forma en que solucionan problemas.
Myocilin Gene Mutation Induced Autophagy Activation Causes Dysfunction of Trabecular Meshwork Cells
Authors: Yan Xuejing , Wu Shen , Liu Qian , Cheng Ying , Zhang Jingxue , Wang Ningli 
Published: May 2022

Trabecular meshwork dysfunction is the main cause of primary open angle glaucoma (POAG) associated with elevated intraocular pressure (IOP). Mutant myocilin causes glaucoma mainly via elevating IOP. Previously we have found that accumulated Asn 450 Tyr (N450Y) mutant myocilin impairs human trabecular meshwork (TM) cells by inducing chronic endoplasmic reticulum (ER) stress response in vitro. However, it is unclear how ER stress leads to TM damage and whether N450Y myocilin mutation is associated with POAG in vivo. Here we found that N450Y mutant myocilin induces autophagy, which worsens cell viability, whereas inhibition of autophagy increases viability and decreases cell death in human TM cells. Furthermore, we construct a transgenic mouse model of N450Y myocilin mutation (Tg-MYOCN450Y) and Tg-MYOCN450Y mice exhibiting glaucoma phenotypes: IOP elevation, retinal ganglion cell loss and visual impairment. Consistent with our published in vitro studies, mutant myocilin fails to secrete into aqueous humor, causes ER stress and actives autophagy in Tg-MYOCN450Y mice, and aqueous humor dynamics are altered in Tg-MYOCN450Y mice. In summary, our studies demonstrate that activation of autophagy is correlated with pathogenesis of POAG.
Development and Validation of Predictive Model—HASBLAD Score—For Major Adverse Cardiovascular Events During Perioperative Period of Non-cardiac Surgery: A Single Center Experience in China
Authors: Zhao Menglin , Shang Zhi , Cai Jiageng , Wu Cencen , Xu Yuan , Zeng Lin , Cai Hong , Xu Mao , Fan Yuanyuan , Li Yanguang , Gao Wei , Xu Weixian , Zu Lingyun 
Published: May 2022

BackgroundMajor adverse cardiovascular events (MACEs) represent a significant reason of morbidity and mortality in non-cardiac surgery during perioperative period. The prevention of perioperative MACEs has always been one of the hotspots in the research field. Current existing models have not been validated in Chinese population, and have become increasingly unable to adapt to current clinical needs.ObjectivesTo establish and validate several simple bedside tools for predicting MACEs during perioperative period of non-cardiac surgery in Chinese hospitalized patients.DesignWe used a nested case-control study to establish our prediction models. A nomogram along with a risk score were developed using logistic regression analysis. An internal cohort was used to evaluate the performance of discrimination and calibration of these predictive models including the revised cardiac risk index (RCRI) score recommended by current guidelines.SettingPeking University Third Hospital between January 2010 and December 2020.PatientsTwo hundred and fifty three patients with MACEs and 1,012 patients without were included in the training set from January 2010 to December 2019 while 38,897 patients were included in the validation set from January 2020 and December 2020, of whom 112 patients had MACEs.Main Outcome MeasuresThe MACEs included the composite outcomes of cardiac death, non-fatal myocardial infarction, non-fatal congestive cardiac failure or hemodynamically significant ventricular arrhythmia, and Takotsubo cardiomyopathy.ResultsSeven predictors, including Hemoglobin, CARDIAC diseases, Aspartate aminotransferase (AST), high Blood pressure, Leukocyte count, general Anesthesia, and Diabetes mellitus (HASBLAD), were selected in the final model. The nomogram and HASBLAD score all achieved satisfactory prediction performance in the training set (C statistic, 0.781 vs. 0.768) and the validation set (C statistic, 0.865 vs. 0.843). Good calibration was observed for the probability of MACEs in the training set and the validation set. The two predictive models both had excellent discrimination that performed better than RCRI in the validation set (C statistic, 0.660, P &lt; 0.05 vs. nomogram and HASBLAD score).ConclusionThe nomogram and HASBLAD score could be useful bedside tools for predicting perioperative MACEs of non-cardiac surgery in Chinese hospitalized patients.
Direct Oral Anticoagulants vs. Vitamin K Antagonists in Atrial Fibrillation Patients at Risk of Falling: A Meta-Analysis
Authors: Gao Xinxing , Huang Donghua , Hu Yuting , Chen Yuanyuan , Zhang Haidong , Liu Fuwei , Luo Jun 
Published: May 2022

BackgroundDirect oral anticoagulants (DOACs) and warfarin are usually used for people with atrial fibrillation (AF). However, for the AF patients at risk of falling, the effectiveness and safety outcomes of DOACs compared with warfarin remain unclear. Therefore, we performed a meta-analysis regarding the effectiveness and safety of DOACs vs. warfarin in AF patients at risk of falling.MethodsA search of the PubMed and Embase databases until November 2021 was performed. We included studies if they satisfied the following criteria: (1) study type: randomized clinical trials or observational cohort studies. (2) Comparisons: effectiveness and/or safety of DOACs (dabigatran, rivaroxaban, apixaban, or edoxaban) compared with warfarin. (3) Study data: the sample size, the number of events in the VKAs or DOACs groups, adjusted risk ratios (RRs), and 95% confidence intervals (CIs). (4) Study outcomes: stroke or systemic embolism (SSE), ischemic stroke, myocardial infarction (MI), all-cause death, and cardiovascular death; major bleeding, major or clinically relevant non-major (CRNM) bleeding, intracranial bleeding, gastrointestinal bleeding, and any bleeding. (5) Study population: patients at risk of falling. According to the Morse Fall Scale, the risk of falling relates to the history of falling, secondary diagnosis, ambulatory aids, intravenous therapy, type of gait, and mental status. In this meta-analysis, if the patient's MFS score is ≥25 points, he will be thought of as having the risk of falling. The adjusted risk ratios (RRs) and 95% confidence intervals (CIs) were pooled by a random-effects model with an inverse variance method.ResultsThree cohort studies were included in our study. For the effectiveness outcomes, the use of DOACs was only associated with a significantly reduced risk of hemorrhagic stroke (RR = 0.28, 95%CI:0.10–0.75) compared with warfarin, but there were no significant differences in stroke or systemic embolism (SSE) (RR = 0.87, 95%CI:0.70–1.08), cardiovascular death (RR = 0.97, 95%CI:0.73–1.29) and all-cause death (RR = 0.90, 95%CI:0.72–1.11). For the safety outcomes, the use of DOACs was significantly associated with reduced risks of major or clinically relevant non-major bleeding (RR = 0.77, 95%CI:0.61–0.98) and intracranial bleeding (RR = 0.26, 95%CI:0.11–0.66) but not major bleeding (RR = 0.78, 95%CI:0.58–1.06).ConclusionsCompared with warfarin, the use of DOACs in AF patients at risk of falling is significantly associated with reduced risks of hemorrhagic stroke, major or clinically relevant non-major bleeding, and intracranial bleeding.
Switching From Proximal to Distal Radial Artery Access for Coronary Chronic Total Occlusion Recanalization
Authors: Achim Alexandru , Szigethy Tímea , Olajos Dorottya , Molnár Levente , Papp Roland , Bárczi György , Kákonyi Kornél , Édes István F. , Becker Dávid , Merkely Béla , Van den Eynde Jef , Ruzsa Zoltán 
Published: May 2022

BackgroundDistal radial access (DRA) was recently introduced in the hopes of improving patient comfort by allowing the hand to rest in a more ergonomic position throughout percutaneous coronary interventions (PCI), and potentially to further reduce the rate of complications (mainly radial artery occlusion, [RAO]). Its safety and feasibility in chronic total occlusion (CTO) PCI have not been thoroughly explored, although the role of DRA could be even more valuable in these procedures.MethodsFrom 2016 to 2021, all patients who underwent CTO PCI in 3 Hungarian centers were included, divided into 2 groups: one receiving proximal radial access (PRA) and another DRA. The primary endpoints were the procedural and clinical success and vascular access-related complications. The secondary endpoints were major adverse cardiac and cerebrovascular events (MACCE) and procedural characteristics (volume of contrast, fluoroscopy time, radiation dose, procedure time, hospitalization time).ResultsA total of 337 consecutive patients (mean age 64.6 ± 9.92 years, 72.4% male) were enrolled (PRA = 257, DRA = 80). When compared with DRA, the PRA group had a higher prevalence of smoking (53.8% vs. 25.7%, SMD = 0.643), family history of cardiovascular disease (35.0% vs. 15.2%, SMD = 0.553), and dyslipidemia (95.0% vs. 72.8%, SMD = 0.500). The complexity of the CTOs was slightly higher in the DRA group, with higher degrees of calcification and tortuosity (both SMD &gt;0.250), more bifurcation lesions (45.0% vs. 13.2%, SMD = 0.938), more blunt entries (67.5% vs. 47.1%, SMD = 0.409). Contrast volumes (median 120 ml vs. 146 ml, p = 0.045) and dose area product (median 928 mGy×cm2 vs. 1,300 mGy×cm2, p &lt; 0.001) were lower in the DRA group. Numerically, local vascular complications were more common in the PRA group, although these did not meet statistical significance (RAO: 2.72% vs. 1.25%, p = 0.450; large hematoma: 0.72% vs. 0%, p = 1.000). Hospitalization duration was similar (2.5 vs. 3.0 days, p = 0.4). The procedural and clinical success rates were comparable through DRA vs. PRA (p = 0.6), moreover, the 12-months rate of MACCE was similar across the 2 groups (9.09% vs. 18.2%, p = 0.35).ConclusionUsing DRA for complex CTO interventions is safe, feasible, lowers radiation dose and makes dual radial access more achievable. At the same time, there was no signal of increased risk of periprocedural or long-term adverse outcomes.
A Survey of Patient-Relevant Outcomes in Pediatric Craniopharyngioma: Focus on Hypothalamic Obesity
Authors: Craven Meghan , Crowley Julia H. , Chiang Lucas , Kline Cassie , Malbari Fatema , Hocking Matthew C. , McCormack Shana E. 
Published: May 2022

ContextIndividuals treated for pediatric craniopharyngioma, a rare, grade 1 brain tumor, frequently develop hypothalamic obesity, a complication often recalcitrant to intervention. Although hypothalamic obesity is known to adversely impact quality of life, less is known about how caregivers and patients experience this condition.ObjectiveOur goal was to examine the approaches that families take towards weight management and the impact on social function in individuals with craniopharyngioma and obesity. Individuals with craniopharyngioma without obesity were included as a comparison.Subjects and MethodsAdult caregivers of children &lt;18y with craniopharyngioma completed a web-based survey posted by a patient advocacy organization between February and July 2020. Questions related to the child’s diagnosis, medications, lifestyle modifications, and social function along with research priorities. Descriptive statistics were generated. Linear regression was used to assess the independent effects of obesity and other covariates on social function.ResultsOf 106 respondents, 60 (57%) reported their child had obesity at the time of survey completion. In contrast, only 6 (5.7%) had obesity prior to craniopharyngioma diagnosis. A majority (92%) of those with obesity had tried limiting calories or carbohydrates; 31% and 69% found these helpful, respectively. Thirty-eight percent had tried weight loss medications (stimulants, metformin, GLP1R-agonists, and topiramate) and 48% found at least one helpful. Both stimulant and anti-depressant use were reported more frequently with obesity. An index (T-score) reflecting social function was lower in the cohort than a population reference, 41 (SD 11) vs. 50 (SD 10), p&lt;0.001. In a linear model, both older age and obesity were independently associated with greater social impairment. Ninety-four percent of respondents caring for a child with obesity (and 79% of all respondents) identified “improving treatments and prevention for hypothalamic obesity” as a key research priority.ConclusionsOnly a minority of individuals with hypothalamic obesity had trialed medication, even though many reported that lifestyle modification was inadequate. Furthermore, social function was significantly impaired overall in survivors compared to a reference cohort, and even more so in individuals with obesity. These findings highlight the opportunity to improve social functioning as an additional potential benefit of improved treatments for hypothalamic obesity.