bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydatid disease of the ribs: An exceptional location
Authors: Douni S , Sabour S , Elmin H T , Marzouki I , Caidi M , Bouchikh M , Achir A 
Published: October 2022

Background. Hydatid disease is a zoonosis caused by larval stages of cestodes belonging to the genus Echinococcus. The rib location is exceptional. It presents a real diagnostic and therapeutic challenge.
Objective. To describe the clinical, serological and radiological features and surgical management of rib hydatidosis.Methods. This is a retrospective study conducted over 4 years, on five cases of rib hydatidosis. We analysed the clinical and radiological presentations and the adopted therapeutic procedure.
Results. The average age of our patients was 44 years, without gender predominance. The clinical signs were dominated by the presence of an immobile swelling of fluid consistency without inflammatory sign, accompanied by moderate and intermittent localised pain. The laboratory assessment was nonspecific. The radiological assessment, including chest X-ray and thoracic computed tomography, with and without contrast, was essential in order to assess the extent of the lesion. Thoracic magnetic resonance imaging was requested in one case because of suspicions of a spinal extension. All of our patients underwent a rib excision accompanied by medical treatment of albendazole 24 hours after the surgery. The follow-up ranged from 1 year to 4 years and did not show any recurrence.
Conclusion. Hydatidosis of the ribs is an exceptional location of hydatid disease. The diagnosis was based on radiology and intraoperative exploration. The treatment remained essentially surgical by rib excision with anthelmintic drugs to prevent recurrence.
Evaluating the neutrophil-to-lymphocyte ratio as an indicator for early referral of patients with COVID-19 pneumonia to a high-care facility
Authors: Retief C A , Retief H J , Van der Merwe S 
Published: October 2022

Background. Early identification of patients at high risk of severe disease requiring referral and treatment at a high‐care facility is imperative in the management of COVID‐19 pneumonia in a limited‐resource setting, as transfer of unstable patients can be detrimental.
Objectives. To examine the value of the neutrophil‐to‐lymphocyte ratio (NLR) calculated on admission to a healthcare facility as a predictor of the need for early referral to a high‐care facility for further treatment.
Methods. We designed a cohort analytical study of 198 patients with COVID‐19 pneumonia admitted to the COVID‐19 unit at Universitas Academic Hospital in Bloemfontein, South Africa, between 20 May and 30 September 2021.
Results. Of the 198 patients enrolled in the study, 134 (67.7%) were admitted to high care and 93 (46.9%) died. The median (interquartile range (IQR)) NLR measured on admission to the hospital was 8.09 (4.90 ‐ 14.86), and the NLR ranged from 0.26 to 136.7. The admission NLR was statistically significantly higher in the high‐care group v. the general ward group (p<0.001). After converting the NLR to log scale, to bring it closer to conditional normality, logistic regression analysis identified log NLR (odds ratio (OR) 4.089; 95% confidence interval (CI) 2.464 ‐ 6.787; p<0.001) and age (OR 1.029; 95% CI 1.004 ‐ 1.056; p=0.024) as significant in determining who will require high care. The area under the receiver operating characteristic curve for the combined model of NLR and age was 0.829 (95% CI 0.767 ‐ 0.891). An NLR cut‐off value of 7.5 (sensitivity 0.7462, specificity 0.7968) has been calculated as the optimal cut‐off value to determine who will need high care. Admission log NLR and age were significant in determining who died (OR 2.067; 95% CI 1.404 ‐ 3.045; p<0.001, and OR 1.043; 95% CI 1.018 ‐ 1.068; p=0.001, respectively).
Conclusion. The NLR measured on admission and age can be used to predict whether a patient with COVID‐19 pneumonia will require high care.
Histone H3K9 demethylase JMJD2B/KDM4B promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells by regulating H3K9me2 on RUNX2
Authors: Kang Pan , Wu Zhiming , Huang Yuxi , Luo Zhen , Huo Shaochuan , Chen Qunqun 
Published: October 2022

Background
A variety of proteins including epigenetic factors are involved in the differentiation of human bone marrow mesenchymal stem cells. These cells also exhibited an epigenetic plasticity that enabled them to trans-differentiate from adipocytes to osteoblasts (and vice versa) after commitment. Further in-depth study of their epigenetic alterations may make sense.

Methods
Chromatin Immunoprecipitation-PCR (ChIP-PCR) was used to detect the methylation enrichment status of H3K9me2 in the Runx2 promoter, alizarin red and alkaline phosphatase (ALP) staining were used to detect osteogenic differentiation and mineralization ability, western blot and quantitative RT-PCR were used to measure the differential expression of osteogenesis-related proteins and genes. Recombinant Lentivirus mediated gain-of-function and loss-of-function study. The scale of epigenetic modification was detected by laser confocal.

Results
Our results showed that compared with human bone marrow mesenchymal stem cells (hBMSCs) without osteogenic differentiation treatment, hBMSCs after osteogenic differentiation significantly promoted osteogenic differentiation and mRNA expression such as JMJD2B/KDM4B, osteogenesis-related genes like Runx2 and FAM210A in hBMSCs cells, suggesting that upregulation of JMJD2B/KDM4B is involved in the promoting effect of osteogenesis. After overexpression and silencing expression of JMJD2B, we found a completely opposite and significant difference in mRNA expression of osteogenesis-related genes and staining in hBMSCs. Overexpression of JMJD2B/KDM4B significantly promoted osteogenic differentiation, suggesting that JMJD2B/KDM4B could promote osteogenesis. In addition, ChIP-PCR showed that overexpression of JMJD2B/KDM4B significantly reversed the methylation enrichment status of H3K9me2 in Runx2 promoter. Furthermore, overexpression of JMJD2B/KDM4B significantly reverses the inhibitory effect of BIX01294 on H3K9me2, suggesting that JMJD2B/KDM4B regulates the osteogenic differentiation of hBMSCs by changing the methylation status of H3K9me2 at the Runx2 promoter.

Conclusions
Taken together, these results suggest that JMJD2B/ KDM4B may induce the osteogenic differentiation of hBMSCs by regulating the methylation level of H3K9me2 at the Runx2 promoter.
Effects of Melatonin Priming on Seed Germination of Wheat under Salt Stress
Authors: Ismaeil Feisal M. , Ahmed Salah Eldeen E. , Jabereldar Abderhim A. , Ibrahim Elshiekh A. , El-Naim Ahmed M. 
Published: October 2022

Melatonin (N-acetyl-5-methoxytryptamine) has been identified as a new growth regulator in plants due to its beneficial effect in abiotic stress reduction. The experiment was conducted at the Wheat Cultivation Department Laboratory, Gezira Scheme, Sudan. To investigate the effects of melatonin priming in alleviating the negative effect of salt stress on seed germination of winter wheat (Triticum aestivum L. cv Elnilein and Imam). Six concentrations were used: control, salt (300 mM NaCl) and four concentrations of melatonin (M) 10, 100, 500 and 1000 μM with salt (300 mM NaCl) add to each concentration: CT, ST, M1+ST, M2+ST, M3+ST, M4+ST. The treatments were arranged in a Randomized Complete Block Design with three replications. The parameters studied included: seed germination rate (%), germination index, mean germination time (d), lengths (cm) and dry weight (mg) of coleoptile and radicle, starch, soluble sugar, and sucrose concentrations, amylase activities, activities of the antioxidant enzymes including superoxide dismutase (SOD), peroxidase (POD), ascorbate peroxidase (APX) and catalase (CAT), reactive oxygen species (ROS) including malondialdehyde (MDA), Hydrogen peroxide (H2O2) contents and superoxide (O2-) production rate, abscisic acid (ABA). The parameters of seedling establishment were: Shoot height, root length, fresh and dry weight of shoot and root. The treatment M3+ST (500 μM Melatonin + 300 mM NaCl) had the highest seed germination rate, germination index lengths and dry weights of coleoptile and radicle, soluble sugar, sucrose concentrations, amylase and antioxidant enzymes activities, and ABA concentration, seedling shoot and root length, and fresh and dry weight of shoot and root in Imam and Elnilein cultivars, respectively.
The study revealed that melatonin priming effectively alleviates salt stress during seed germination and seedling establishment in winter wheat.
Changing beliefs in repressed memory and dissociative amnesia
Authors: Otgaar Henry , Mangiulli Ivan , Riesthuis Paul , Dodier Olivier , Patihis Lawrence 
Published: October 2022

AbstractIn three studies, we examined whether beliefs in repressed memory and dissociative amnesia could be changed. Participants provided agreement ratings to statements related to repressed memory and dissociative amnesia. Then, they received a university course which included education on the science of memory. Following this, participants had to re‐rate the statements. In Study 3, at Times 1 and 2, participants also received a case vignette on a therapy‐induced recovered memory and rated several statements related to this case. Participants who received education on the science of memory were less likely to agree with statements endorsing repressed memory and dissociative amnesia—and participants were more likely to state that the case vignette involved a false memory. Providing education on the science of memory can help people (e.g., legal professionals, people from the general population) to use critical thinking on the topic of repressed memory and dissociative amnesia.
Ulric Neisser's contribution to the study of autobiographical memory accuracy
Authors: Sotgiu Igor 
Published: October 2022

AbstractUlric Neisser was the initiator of the contemporary psychology of autobiographical memory, as well as the founder of the ecological approach to human cognition. The present article reviews his empirical and theoretical contributions to an issue which is at the heart of the contemporary debate on autobiographical memory: that is, autobiographical memory accuracy. From the early 1980s to the mid‐1990s, Neisser empirically investigated this topic in a variety of memory research fields including legal testimony, flashbulb memory, and childhood memory. Overall, the empirical studies that Neisser conducted in these fields led him to conceptualize autobiographical memory as a reconstructive process serving the specific goals pursued by the rememberer at a particular time and place, and dynamically varying according to the social context in which autobiographical experiences are recalled. In the conclusions, the author discusses the influence of Neisser's empirical and theoretical work on autobiographical memory accuracy on the current memory literature.
Directed Conformational Switching of a Zinc Finger Analogue Regulates the Mechanosensing and Differentiation of Stem Cells
Authors: Zhao Pengchao , Wang Ziqi , Xie Xian , Jiang Tianshen , Chun‐Him Lai Nathanael , Yang Boguang , Yi Bo , Fu Hao , Zhang Kunyu , Li Gang , Wang Yi , Bian Liming 
Published: October 2022

AbstractThe dynamic conformational changes in the secondary structures of proteins are essential to their functions and can regulate diverse cellular events. Herein we report the design of a synthetic polymer‐based secondary structure analogue of a zinc finger (ZnF) by introducing a zinc coordination motif to overcome the free energy barrier predicted by theoretical calculations and fold‐free polymer chains. The conformational switching between unfolded and folded state of the ZnF analogue can be triggered in situ to drastically manipulate the accessibility of conjugated cell adhesive ligands to the cell membrane receptors, thereby effectively controlling the adhesion, spreading, mechanosensing, and differentiation of stem cells. We believe that emulating the dynamic secondary structures of proteins via rational design of a folded synthetic polymer–cation complex is a promising strategy for developing bioactive materials to mediate desired cellular functions.
Metal‐Ligand Cooperativity to Assemble a Neutral and Terminal Niobium Phosphorus Triple Bond (Nb≡P)
Authors: Senthil Shuruthi , Kwon Seongyeon , Fehn Dominik , Im Hoyoung , Gau Michael R. , Carroll Patrick J. , Baik Mu‐Hyun , Meyer Karsten , Mindiola Daniel J. 
Published: October 2022

AbstractDecarbonylation along with P‐atom transfer from the phosphaethynolate anion, PCO−, to the NbIV complex [(PNP)NbCl2(NtBuAr)] (1) (PNP=N[2‐PiPr2‐4‐methylphenyl]2−; Ar=3,5‐Me2C6H3) results in its coupling with one of the phosphine arms of the pincer ligand to produce a phosphanylidene phosphorane complex [(PNPP)NbCl(NtBuAr)] (2). Reduction of 2 with CoCp*2 cleaves the P−P bond to form the first neutral and terminal phosphido complex of a group 5 transition metal, namely, [(PNP)Nb≡P(NtBuAr)] (3). Theoretical studies have been used to understand both the coupling of the P‐atom and the reductive cleavage of the P−P bond. Reaction of 3 with a two‐electron oxidant such as ethylene sulfide results in a diamagnetic sulfido complex having a P−P coupled ligand, namely [(PNPP)Nb=S(NtBuAr)] (4).
Effects of residual resistance factor in the mobility control of the polymer flooding
Authors: Cao Jie , Zhu Shijie , Shu Zheng , Shi Leiting 
Published: October 2022

AbstractTo broaden the application of the polymer flooding in complex reservoirs, the residual resistance factor (RRF) is sought to make up for the limitations of high‐viscosity polymer flooding. First, the polymer solution rheology, adsorption and retention behaviors were mathematically characterized, and subsequently substituted into the equation of motion of the aqueous phase to build a mathematical model of the polymer flooding percolation. Second, based on the built numerical model, the formation process of seepage resistance and pressure propagation characteristics of polymers with a high RRF in the porous media were investigated. Lastly, the effects arising from viscosity and RRF on the flow control of the polymer flooding were explored by comparing the injection capacity, crude oil utilization and profile control capacity of different permeable formations at different development stages. As revealed by the results, the RRF was found to be more favorable than the “viscosity” parameter in improving the injection capacity at the polymer flooding stage. Moreover, it was found to slow down the water‐cut increase at the subsequent water flooding stage and reduce the difference between the oil recovery rate and injection pressure at different stages. Furthermore, the viscosity was primarily adopted to facilitate oil recovery of medium and high‐permeability formations by increasing the oil replacement efficiency, while the RRF was primarily dependent on the regulation of interlayer water absorption differences, thus mobilizing the remaining oil under the low‐permeability formations.
Effects of ambient pressure on structural characteristics of polyacrylonitrile pre‐oxidized fibers
Authors: Shen Zheyu , Lan Zecheng , Wang Yu , Xu Lianghua 
Published: October 2022

AbstractDuring the pre‐oxidation process, skin‐core structure is easily formed in the fibers due to the competitive mechanism of oxygen capture and oxygen diffusion, which would degrade the tensile properties of the resulting carbon fibers. To prepare high‐performance carbon fibers, it is vital to optimize the radial structure of polyacrylonitrile (PAN) pre‐oxidized fibers. Methods commonly used to solve the skin‐core structure would result in low productivity and comprehensive performance. Here, we examine the effects of pressure on the chemical structure and the evolution of radial structure in PAN pre‐oxidized fibers under 225°C in the air, by using 13C Solid‐state NMR analysis (13C‐NMR), Optical density test (OD), and Thermogravimetric Analysis (TG). It was found out that under the positive pressure of 30 kPa, the reaction area expands to the core of the fibers with the shell thickness increasing from 88.11% under normal pressure to 98.67%, and the radial structure homogeneity is effectively improved. As the pressure increases above 22 kPa, oxygen diffusion is accelerated, allowing for breaking the barrier of the fiber surface capture and promoting the oxygen catalytic cyclization reaction in the core. Consequently, PAN pre‐oxidized fibers prepared under positive pressure have a more uniform radial structures and higher thermal stability. The carbonization yield at 800°C of the fibers prepared at 30 kPa is 13.10% higher than that of the fibers prepared at atmospheric pressure.
An NMR relaxation study of magnesium borohydride in solid
Authors: Kim Chul 
Published: October 2022

AbstractThe spin–lattice relaxation phenomenon is a good tool for obtaining the thermodynamical parameters of solid metal borohydrides. In the process of deriving the motional parameters from the NMR experimental data, it is very important to adequately interpret the spin–lattice relaxation data. By more precisely considering the quadrupolar interaction of 11B and intermolecular 1H‐1H dipole–dipole interactions, the activation energies and correlation times of the rotational motions of BH4 group in solid magnesium borohydride could be more accurately determined, and the spin–lattice relaxation phenomenon of the quadrupolar nucleus could be more appropriately understood.
Highly Efficient Catalysts of AuPd Alloy Nanoparticles Supported on 3D Ordered Macroporous Al2O3 for Soot Combustion
Authors: Li Renjie , Jin Baofang , Ma Teng , Liang Yutai , Wei Yuechang , Yu Xuehua , Li Jianmei , Liu Jian , Zhao Zhen 
Published: October 2022

AbstractThe catalysts of Au−Pd bimetallic nanoparticles with different Au/Pd ratios supported on 3DOM Al2O3 were synthesized by micropores‐diffused reduction (MDR) method. Compared with supported monometallic Au or Pd catalysts, supported bimetallic Au−Pd nanoparticle catalysts, especially Au2‐Pd2/3DOM Al2O3, show higher catalytic activity for soot combustion due to good synergetic effects between gold and palladium. Au/Pd ratio has a significant influence on the chemical states and size of bimetallic nanoparticles. The co‐presence of Au is favorable for the formation of metallic Pd instead of PdO. And the size of Au−Pd bimetallic nanoparticles gradually decreases with increasing Au/Pd ratio. The effect of water in the reaction atmosphere and SO2‐presulfurization of the catalyst on the activity is also studied. It is unexpected that Au2‐Pd2/3DOM Al2O3 catalysts with SO2‐presulfurization has higher catalytic activity than the fresh catalysts. The increased activity is related to the formed surface aluminum sulfate and enhanced acidity.
Case reports of large and symptomatic abdominal tumors in newborns: Pitfalls, difficulties in management, and surgical decision making
Authors: Laconi Francesco , Bischoff Charline , Michelet Daphne , Loron Gauthier , Bednarek Nathalie , Poli‐Merol Marie‐Laurence , Pons Maguelonne , Boudaoud Nadia 
Published: October 2022

AbstractBackgroundLarge and rapidly growing abdominal tumors may result in fatal outcomes in newborns. In some cases, a rapidly worsening clinical condition requires surgical decision‐making despite the absence of a precise histological diagnosis. In these situations, there is neither a guide nor consensus.CaseWe highlight our experience with five patients with large abdominal tumors and assess the available literature for the best possible management of a rare condition.ConclusionIn these cases, laparostomy should be considered as a life‐saving procedure. If the liver is involved and coagulopathy is present, prognosis is often compromised.
Exploring the Potential of Multinuclear Solid‐State 1H, 13C, and 35Cl Magnetic Resonance To Characterize Static and Dynamic Disorder in Pharmaceutical Hydrochlorides
Authors: Szell Patrick M. J. , Rehman Zainab , Tatman Ben P. , Hughes Leslie P. , Blade Helen , Brown Steven P. 
Published: October 2022

AbstractCrystallographic disorder, whether static or dynamic, can be detrimental to the physical and chemical stability, ease of crystallization and dissolution rate of an active pharmaceutical ingredient. Disorder can result in a loss of manufacturing control leading to batch‐to‐batch variability and can lengthen the process of structural characterization. The range of NMR active nuclei makes solid‐state NMR a unique technique for gaining nucleus‐specific information about crystallographic disorder. Here, we explore the use of high‐field 35Cl solid‐state NMR at 23.5 T to characterize both static and dynamic crystallographic disorder: specifically, dynamic disorder occurring in duloxetine hydrochloride (1), static disorder in promethazine hydrochloride (2), and trifluoperazine dihydrochloride (3). In all structures, the presence of crystallographic disorder was confirmed by 13C cross‐polarization magic‐angle spinning (CPMAS) NMR and supported by GIPAW‐DFT calculations, and in the case of 3, 1H solid‐state NMR provided additional confirmation. Applying 35Cl solid‐state NMR to these compounds, we show that higher magnetic fields are beneficial for resolving the crystallographic disorder in 1 and 3, while broad spectral features were observed in 2 even at higher fields. Combining the data obtained from 1H, 13C, and 35Cl NMR, we show that 3 exhibits a unique case of disorder involving the +N−H hydrogen positions of the piperazinium ring, driving the chloride anions to occupy three distinct sites.
Preparation of Iron‐Doped Carbon Dots and Their Application in Photocatalytic Reduction of Carbon Dioxide
Authors: Dang Yong‐Qiang , Li Boni , Feng Xiangyu , Jia Jia , Li Keke , Zhang Yating 
Published: October 2022

AbstractPhotocatalytic carbon dioxide (CO2) reduction technology is considered a promising approach to alleviate greenhouse gas emissions in the earth's atmosphere. Carbon dots (CDs), which possess good optical properties, are of keen interest in the field of photocatalysis. Iron (Fe), a transition metal element with vacant 3d orbital that contributes to the electron‐transfer process, is a promising metal dopant for CDs that allows for the preparation of multifunctional CDs. Fe‐doped carbon dots (Fe−CDs) were synthesized using ethylenediamine tetraacetic acid disodium (EDTA‐2Na) and ferric chloride (FeCl3 ⋅ 6H2O) through a simple one‐step hydrothermal method. The chemical structure of the obtained Fe−CDs was studied, and their activity for the photocatalytic reduction of CO2was tested. The results show that Fe doping amount of 13.0 wt.% is the most favorable for the photocatalytic reaction. The maximum photocatalytic reduction of CO2to methanol reaches 654.28 μmol ⋅ g−1 ⋅ h−1within 6 h, which is about 2.6 times of the methanol yield of CDs, which is attributed to high electron transfer rate of Fe dopant.