bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of algorithms in building construction preparation
Authors: Máder Patrik Márk , Rák Olivér , Bakai Nándor , Etlinger József , Zagorácz Márk 
Published: May 2022

Abstract
Nowadays, it is increasingly important to develop economical construction processes and determine predictable costs. The current level of technology offers countless, even undeveloped opportunities to support architectural, engineering, and construction processes. Building information models created as results of design processes and databases associated with them can provide an appropriate base to fulfill the requirements. However, this information is mainly available only for the largest projects; the possibilities offered by traditional editable vector files (e.g., *.DWG) should also be examined. This study analyzes the efficiency increasing possibilities that can be achieved using low-detail 3D models generated by algorithms and applying 2D-based digital quantity estimation workflows.
Absceso cerebral. Reporte de caso
Authors: Soliz Rivero Gardenia , Cullacay Buñay Silvia Alejandra , Sánchez Troya Loida Betzabe , Morales Lluman Washington Abel 
Published: May 2022

Introducción: el absceso cerebral, caracterizado por colecciones supurativas focales del parénquima cerebral, constituye un problema de salud mundial por su alta morbimortalidad y carga económica para el sistema de salud.
Caso Clínico: mujer de 35 años, el último trimestre de embarazo cursó con otitis media supurativa derecha sin tratamiento. Durante el puerperio mediato, presenta cefalea intensa, se automedica analgésicos orales sin mejoría. Acude a hospital, donde realizan Tomografía Axial Computarizada (TAC), reportando dos lesiones hipodensas, encapsuladas en el lóbulo temporal, rodeadas de edema vasogénico con realce en anillo post contraste; en la Resonancia Nuclear Magnética (RNM), las dos colecciones restringen en secuencia de difusión con caída de la señal del Coeficiente de Difusión Aparente (ADC). Se inicia antibiótico amplio espectro y drenaje quirúrgico inmediato con colocación de dren externo. Evolución favorable.
Conclusión: el absceso cerebral es potencialmente mortal, su pronóstico depende del diagnóstico oportuno. La infección ótica severa contribuyó al desarrollo de esta patología, siendo una causa rara en adultos.
Surface Heat Flow, Deep Formation Temperature, and Lithospheric Thickness of the Different Tectonic Units in Tarim Basin, Western China
Authors: Liu Yuchen , Liu Bo , Fu Jian , Kang Le , Li Siqi 
Published: May 2022

Abstract
Herein, the new collected well-testing temperature as well as continuous steady-state temperature logs were achieved for the analysis of deep thermal structural characteristics and current thermal states of various tectonic units in Tarim Basin. Generally, geothermal gradient fluctuates in 14.6-31.1°C/km, the heat flow ranges between 31.6 and 59.2 mW/m2 with the average heat flow of 43.2 mW/m2, and these values are typical of low heat flow background in Precambrian craton basins. Furthermore, estimated formation temperature spatial distributions at 6~8 km depth are the same and are mainly under the control of basement structural pattern. At 6000 m depth, temperature is 99-188°C, which become 126-242°C and 113-215°C at 7000 m and 8000 m depths, respectively. These findings confirmed that heat flow in Tarim Basin was relatively low with similar geothermal regimes to other Precambrian craton basins around the globe. In addition, 1D theoretical crustal thermal structures in Tarim Basin were established based on the solution of the equation of steady-state heat conduction. The findings revealed that “thermal” lithosphere maximum thickness in Tarim Basin is witnessed in Manjiaer sag. Tazhong uplift thermal state differs from those of Tabei uplift and Manjiaer sag. Tazhong mantle heat flow is 23.9 mW/m2, which accounts for 48.8% of surface heat flow. Hotter thermal states of Tazhong uplift generated temperatures as high as ∼690°C in Moho. Tarim Basin heat flow distribution reveals that crustal heat flow plays a more significant role in surface heat flow and possesses typical “hot crust and cold mantle” model thermal structure properties.
Metamorphism of the Korvatundra Structure of the Lapland–Kola Orogen (Arctic Zone of the Fennoscandian Shield)
Authors: Nitkina E.A. , Belyaev O.A. , Dolivo-Dobrovol’skii D.V. , Kozlov N.E. , Kaulina T.V. , Kozlova N.E. 
Published: May 2022

Abstract
We study the P–T conditions and age of metamorphic evolution of the rocks that make up the Korvatundra structure in the northeast of the Fennoscandian Shield. The rocks underwent progressive metamorphism of the amphibolite facies at 625–660 ºC and 8.7–8.8 kbar 1945 ± 34 Ma (Sm–Nd data). The pegmatite cutting the metamorphic paragenesis that formed at this stage has an age of 1917 ± 6 Ma (zircon U–Pb data). Metamorphic transformations after 1917 Ma are manifested locally as discrete zones of blastomylonites in the rocks of the northern part and some inner sites of the Korvatundra structure. Both local increases and decreases in temperature and pressure are possible in these zones. The formation of light titanite with an age of 1863 ± 44 Ma marks the next stage of shear strain. Low-temperature alterations (chloritization and silicification) took place in the zones of final deformations 1722 ± 5 Ma (Rb–Sr data). Beginning from 1.94 Ga, the general deformational and metamorphic history of the Korvatundra structure, Lapland Granulite Belt, and Tana Belt confirms the assumption of the formation of a single inverted metamorphic zoning within the Korvatundra structure and the overlying Lapland–Kolvitsa Collision Belt in the Paleoproterozoic. The obtained data supplement the idea of the Paleoproterozoic geodynamic evolution of the Lapland–Kola orogen.
The Triassic of New Siberian Islands Archipelago and Its Position in the Structure of Sedimentary Cover of the Laptev Sea Shelf
Authors: Nikitenko B.L. , Devyatov V.P. , Konstantinov A.G. , Sobolev E.S. , Yadrenkin A.V. , Pestchevitskaya E.B. , Lebedeva N.K. , Goryacheva A.A. 
Published: May 2022

Abstract
The geological study of the Mesozoic sections of the New Siberian Islands archipelago and Asian coastal sections of the Arctic Ocean plays a key role in tying the results of comprehensive studies with seismic data on the Laptev Sea shelf and the western part of the East Siberian Sea. Therefore, it is extremely important to improve the subdivision of the Triassic system of the New Siberian archipelago and to define the position of the system in the structure of the Laptev Sea shelf sedimentary basin. The results of our study were used to improve and refine the lithostratigraphic subdivision of the Triassic in the study area and to recognize a distinct interregional stratigraphic marker, i.e., the Czekanowski Formation (lower Olenekian). In terms of genetic, structural, and sedimentological features, the Triassic strata were grouped into two Groups: the Reshetnikov Group (Induan–upper Ladinian) and the Svetlaya Group (Ladinian–Rhaetian), reflecting major stages of sedimentation. For the Triassic of the eastern Laptev Sea shelf and adjacent onshore areas, the facies zonation scheme has been developed and refined on a unified basis. Based on their structure, the Phanerozoic sections of the study area can be considered as a part of the intermediate structural stage of the Laptev Sea plate at the margins of the Siberian craton.
Determination of immune response persistence after SARS-CoV-2 infection by ELISA analysis of nucleocapsid specific IgG
Authors: Kldiashvili Ekaterina , Iordanishvili Saba , Shotadze Tamar , Lomidze Mariam 
Published: May 2022

Abstract
Objectives
The severe acute respiratory syndrome coronavirus (SARS-CoV-2) causes Corona Virus Disease-2019 (COVID-19) and a global pandemic resulting in major changes in our daily habits and social behaviors. The mechanisms and the peculiarities of immune response against SARS-CoV-2 are not yet determined. To address this question, we initiated the study aimed to determine the persistence of immune response against SARS-CoV-2.
Results
Blood samples of the registered participants (49 registered participants - 35 females and 14 males; 17-55 years old age group) with clinically documented episodes of SARS-CoV-2 infections were collected. The samples were analyzed for quantitative determination of IgG against nucleocapsid protein of SARS-CoV-2 by enzyme linked immunoassay (ELISA) method. It has been revealed that: a) 16 (32.7%) are negative; b) 5 (10.2%) samples are equivocal; and c) 28 (57.1%) samples are positive for IgG SARS-CoV-2 nucleocapsid protein. The IgG against SARS-CoV-2 nucleocapsid protein can be used as the possible marker of the immune response. The persistence of COVID-19 immune response after 6 months of the clinical episode has been revealed. Despite of the quantity decreasing of IgG against SARS-CoV-2 nucleocapsid protein with time the exact correlation specific to the decreasing tendency has not been determined.
Novel mechanisms of the transformations of the G·C base pairs in Watson-Crick and Hoogsteen configurations via the mutual rotations of the bases and proton transfer: A quantum-chemical investigation
Authors: Brovarets' Ol'ha , Muradova Alona , Hovorun Dmytro 
Published: May 2022

Abstract
In this study for the first time at the MP2/6-311++G(2df,pd)//B3LYP/6-311++G(d,p) level of theory it was comprehensively investigated unusual conformationally-tautomeric transformations of the G*·C*(WC), G*·C*(rWC), G*·C*t(rWC), G*t·C*(rH) and G*t·C*t(rH) base pairs - G*·C*(WC)↔G*t·C(rwН)↑↔G*N7·C*(rwH)↑↔G*N7·C*(wH)↑↔G*t·C*O2(wH)↑↔ G*t·C*O2(rwH)↑, G*·C*(rWC)↔G*t·C*O2(rwWC)↓/↔G*t·C*O2(wH)↑, G*·C*t(rWC)↔G*t·C*tO2(wН)↓↔G*t·C*tO2(rwH)↓/↔G*t·C*tO2(rwWC)↓↔G*t·C*tO2(wWC)↓, G*t·C*(rH)↔G*·C*O2(wWC)↑/↔G*·C*O2(wH)↓ and G*t·C*t(rH)↔G*·C*tO2(wWC)↑/ ↔G*·C*tO2(rwH)↓↔G*·C*tO2(wH)↓. It was reliably established that they occur through the mutual rotations of the G and C bases around intermolecular H-bonds and proton transfer along the intermolecular H-bonds. These novel conformationally-tautomeric tranformations are intrinsically inherent properties of the Watson-Crick (WC) and Hoogsteen (H) G·C base pairs and lead to their transformation into the wobble (w) or reverse wobble (rw) base pairs. These conformationally-tautomeric transformations of the G·C base pairs are accompanied by the rearrangement of the intermolecular H-bonds and changing of the dipole moments.
Cough presentation and cough-related healthcare utilization in tertiary care: analysis of routinely collected academic institutional database
Authors: An Jin , Lee Ji-Hyang , Won Ha-Kyeong , Kang Yewon , Kwon Hyouk-Soo , Lee Jae-Seung , Lee Sei Won , Kim Tae-Bum , Oh Yeon-Mok , Cho You Sook , Lee Sang-Do , Moon Hee-Bom , Song Woo-Jung 
Published: May 2022

Abstract
Purpose: Routinely collected data (RCD) from electronic health records (EHR) are useful for studying disease epidemiology in the real world. We examined cough presentation and cough-related healthcare utilization using an academic institutional EHR database in Korea.Methods: This is a retrospective cohort study of patients with subacute (3–8 weeks) or chronic cough (>8 weeks in duration) referred to allergy and asthma clinics. Cases were identified using the search of the chief complaint in the data fields. Structured data were analyzed, including demographics, medical history, symptoms, and diagnostic tests. Healthcare utilization for 1 year was assessed for drug prescriptions, additional tests, or outpatient visits.Results: Among 28,312 new referrals for 8 years, cough was the chief complaint in 13,223 cases (46.7%); 3,810 subacute and 7,150 chronic cough patients were analyzed. Common demographic profile was middle-aged woman (mean age 52.1 years, and female 63%). Cough was frequently accompanied by anterior nasal (about 50%), lower airway (30%), or acid reflux disease symptoms (20%), and by test abnormalities in chest X-rays (14%), spirometry (23%), or T2 inflammation markers (40%). Chronic cough patients frequently required additional tests (chest CT scan: 24%), drug prescriptions (codeine: 21.5% and oral steroids: 9.9%), and long-term healthcare utilization (16.0%) for 1 year. Conclusions: This RCD analysis suggests that cough is a common chief complaint at allergy and asthma clinics, but the clinical presentation may be heterogeneous. Further studies are needed to understand long-term outcomes and reduce the disease burden.
Characteristics of gelatin from pig skin waste; effect of different organic acids used on pre-thermal treatment
Authors: LATORRE MARIA EMILIA , Velazquez Diego Ezequiel , Palacio Maria Ines , Sanchez Mariana Marta 
Published: May 2022

Abstract
Upcycled products prevent food waste and contribute to a sustainable solution to obtain novel by‑products. This research paper presents the properties and characteristics of gelatin obtained from pig skin waste using different organic acids solutions as a pretreatment that have been studied. The pH, hydroxyproline content (Hyp), the thermal properties and the color of the product were evaluated. All acids used are food-grade acids. There were differences the gelatin yield showed among the food‑grade acid solutions pretreatment, Acetic (AH), Latic (AL), Citric (AC) and Ascorbic acid (AA) (0.5M). AH and AA treatments resulted in higher gelatin Hyp content than AL and AC. The pH of each gelatin solution was 3.46, 3.10, 2.76 and 2.30 for AH, AA, AL and AC, respectively. The AH showed two gel-sol thermal transitions at 57.8°C and 127.5°C while treatments AL, AC, and AA showed only one thermal transition at 122.9°C, 121.4°C and 97.2°C, respectively. The DSC enthalpies energies result in differences between gelatin-films. The acid pretreatment affected the brightness of the gelatin-films and the color parameters. The lowest lightness resulted from AA, and the highest a* and b* color parameters were observed in the AC gelatin‑film. The results showed that the use of food-grade acids to obtain gelatin from waste pig skin is promising. Moreover, a good Hyp content can be obtained from all such treatments. The food‑grade acids used affect the gelatin thermal, gelation and color properties. The results suggest that the acid pretreatment causes substantive changes in protein functionality.
Safety and efficacy of trifluridine/tipiracil in treatment of patients with advanced gastric cancer having ascites
Authors: Matsumoto Toshihiko , Yamamura Shogo , Ikoma Tatsuki , Kurioka Yusuke , Doi Keitaro , Yasuda Tomoyo , Boku Shogen , Kawai Takeshi , Shibata Nobuhiro , Nagai Hiroki , Tsuduki Takao , Shimada Takanobu , Matsumoto Yusuke , Tsumura Takehiko , Takatani Masahiro , Yasui Hisateru , Satake Hironaga 
Published: May 2022

Abstract
Background: Trifluridine/tipiracil (FTD/TPI) is an oral chemotherapy comprising a thymidine-based nucleoside analog and a thymidine phosphorylase inhibitor. The FTD/TPI versus placebo in patients with heavily pretreated metastatic gastric cancer trial showed that FTD/TPI is effective with manageable toxicity in these patients. However, data on the effect of FTD/TPI on patients with advanced gastric cancer (AGC) having ascites are limited.Methods: We retrospectively collected and analyzed the clinicopathologic data of patients with AGC who had received FTD/TPI monotherapy in our institutions from September 2019 to July 2021.Results: A total of 53 patients were included in this study. The median age was 70 (range, 37‒85) years, 39 patients were men, the numbers of patients with Eastern Cooperative Oncology Group performance status scores 0, 1, and 2 were 10, 39, and 4, respectively, and 27 patients had diffuse-type histology. A total of 29 patients had ascites, among whom 14 had massive ascites. The response rate and disease control rate (DCR) were 2% and 35%, respectively. The median progression-free survival was 2.4 months and median overall survival (OS) was 5.8 months. Patients with ascites exhibited significantly shorter OS (8.6 vs. 4.7 months, P=0.0291) than those without ascites, and DCR (54% vs. 18%, P=0.0055) was significantly worse in patients with ascites. There was no significant difference in the frequency of occurrence of adverse events of grade 3 or higher between patients with and without ascites.Conclusion: FTD/TPI has a moderate, although inadequate, effect on patients with AGC having ascites.
User Design and Development of a Culturally Inclusive, Online Wisdom Community
Authors: Cifuentes Lauren , Perry Michelle 
Published: May 2022

Abstract
Faculty and graduate students in an Educational Design and Learning Technologies program collaboratively developed their degree programs’ online wisdom community as a project in a Foundations of Learning Design course. Community goals established by program faculty and students were to facilitate learning community, enhance identity as professional educational technologists, expand professional knowledge for the duration of their studies toward their degrees, and leverage and prepare members to use various learning technologies. Sociocultural learning theories and user design frame the study. We applyied educational design and development research methods to analyse and explore Pre-Course and Post-Course surveys, an online discussion, the students’ design and development documents, and student-constructed prototype wisdom communities. Findings were activities and features learning technologies students wanted addressed in their Educational Design and Learning Technologies wisdom community as well as suggestions for implementation. We share guidelines for designing a culturally inclusive community that is responsive to students’ interests and needs for building professional identity as instructional designers and educational technologists.
Disentangling structural and functional responses of native versus alien communities by canonical ordination analyses and variation partitioning with multiple matrices
Authors: Sîrbu Ioan , Benedek Ana-Maria , Brown Bryan L. , Sîrbu Monica 
Published: May 2022

Abstract
Freshwaters are under accelerated human pressure, and mollusk communities are among its most sensitive, threatened, and valuable components. To the best of our knowledge, the overall effects of damming, environment, space, and invasive alien mollusk species, on the structural and functional responses of native mollusk communities were not yet studied synthetically. Using historical information and recent data from a river, we aimed to investigate and disentangle these effects and evaluate the differences in structural and functional responses of natives and alien invasives to the same predictors. Variation partitioning showed that alien species were as important predictors as were environmental factors and time in explaining species composition of native freshwater mollusk communities. Aliens were more independent of environmental conditions than natives and responded to different drivers, partially explaining their invasion success. The increased abundance of some alien gastropods was positively related to taxonomic diversity, while certain alien bivalves were negatively associated with the functional diversity of native communities. We introduce a cumulative variation partitioning with multiple response (native and alien) and predictor matrices, along with a diagram to show their relations, advocating for a conceptual shift in future ecology, "from variables to matrices" and from "multivariate analyses to multi-matrix statistical modeling."
Factorial Validity of the Self-Compassion Scale among University Female Students: A Comparative Study Between Saudi and Egyptian culture
Authors: Alzamil Wafaa , Alabdulkareem Rashid , Alkasabi Manal , Almusfir May F. , Ahmed Emad 
Published: May 2022

Abstract
The study aimed to verify the factorial construction of the self-compassion scale across cultures. The study is based on Neff et al.’s (2017) model that explains self-compassion in its three dimensions in a bipolar manner. The researchers relied on the Neff (2003) scale for self-compassion, the abbreviated form of 26 items. The participants consisted of 1039 university students, divided in terms of culture into 521 students at Zagazig University in Egypt, and 518 at Princess Nourah Bint AbdulRahman University in Saudi Arabia. The scale was prepared in the same electronic form. All females of the sample were informed of the purpose of the study. The sample was chosen randomly. Exploratory factor analysis was used to test the stability of items on the dimensions and results showed the stability of the kindness with self, isolation, shared humanity, and self-judgment dimensions. Confirmatory factor analysis results reached the best fit for the total sample. Factor analysis across the two groups was used to verify the existence of differences between Saudi and Egyptian cultures. The results revealed that the Egyptian environment model is superior to its Saudi counterpart, and it has been proven that there are no differences between the two cultures using the factorial differences indicators RSMEA, NNFI, GFI, and SRMR.
Possible protective effect of Costus root extract on liver of rat prior exposure with melamine: The hematology, biochemistry, histopathology and ultrastructure study
Authors: Hassan Khalid 
Published: May 2022

Abstract
The current study evaluated the protective effect of Costus root extract against the hematology, biochemistry, histopathology and ultra-structure changes induced in rat liver due to the sub chronic exposure with melamine. In recent years manufacturers adding melamine (MA) to milk to increase its protein content but this led to toxic effects on many organs such as kidneys, liver, brain, etc. in experimental animals. Recent studies have proved that Costus root extract has a hepatoprotective role and has many health-related benefits showed against various toxins related to oxidative stress. Eighty adult albino rats (200–250 gm) were further allocated into 04 equal sets; set 01 exposed with distilled water orally, set 02 exposed with costus plant extract (0.4 mg/ kg) orally, set 03 exposed with MA (50mg/kg b.wt/day), and set 04 exposed with MA (50 mg/kg b.wt/day) plus costus plant extract (0.4 mg/ kg) orally for the period of two months. The experimental rats were exposed to general anesthesia before the sacrifice and the sample of blood and liver were collected. The samples were further prepared for histopathological and ultrastructural examinations. The results revealed that MA treatment (set 03) caused hematological, biochemical, histopathological, and ultrastructural alterations. Co-administration of Costus root extract with MA ameliorated most of the toxic effects of melamine (set 04). The results demonstrated that Costus root extract exhibited a protective effect by decreasing the toxic pathological changes caused by MA in the liver of albino rats.
AMPK facilitates the hypoxic ventilatory response through non‑adrenergic mechanisms at the brainstem
Authors: MacMillan Sandy , Evans A. Mark 
Published: May 2022

Abstract
We recently demonstrated that the hypoxic ventilatory response (HVR) is facilitated by the AMP-activated protein kinase (AMPK) in catecholaminergic neural networks that likely lie downstream of the carotid bodies within the caudal brainstem. Here we further subcategorise the neurons involved, by cross-comparison of mice in which the genes encoding the AMPK‑α1 (Prkaa1) and AMPK‑α2 (Prkaa2) catalytic subunits were deleted in catecholaminergic (TH-Cre) or adrenergic (PNMT-Cre) neurons. The HVR was markedly attenuated in mice with AMPK‑α1/α2 deletion in catecholaminergic neurons and modestly augmented in mice with AMPK‑α1/α2 deletion in adrenergic neurons when compared against a variety of controls (TH-Cre, PNMT‑Cre, AMPK‑α1/α2 floxed). Moreover, AMPK‑α1/α2 deletion in catecholaminergic neurons precipitated marked hypoventialtion and apnoea during poikilocapnic hypoxia, relative to controls, while mice with AMPK‑α1/α2 deletion in adrenergic neurons entered relative hyperventilation with reduced apnoea frequency and duration when compared to controls. We conclude, therefore, that AMPK facilitates the HVR through non‑adrenergic mechanisms, where adrenergic pathways may deliver weaker negative inputs.