bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Pentahelix Collaboration on Tourism Development of West Sumbawa Regency
Authors: Pattaray Anas , Nipri Nanda 
Published: April 2022

AbstractWest Sumbawa Regency is decadent with natural and cultural tourism potential. West Sumbawa has beauty and provides opportunities for the tourism industry. However, this potential has not been managed optimally, so tourism business activities, especially product marketing, have not found the right formula. One of the efforts that need to be made is the partnership and collaboration of tourism stakeholders. This study examines how much influence stakeholder partnerships have on the marketing of tour packages in the West Sumbawa Regency. The primary stakeholder partnership was studied using a descriptive quantitative approach with multiple regression data analysis methods. This study found that the correlation of stakeholders with the marketing of tour packages has a value of 57.2%. Simultaneously, stakeholders influence the marketing of tour packages significantly by 62.1%. Meanwhile, the tourism association variable as a private stakeholder has a high percentage of 46.6% of its influence on tourism package marketing.Keywords: West Sumbawa, Tour Packages, Partnership. AbstrakKabupaten Sumbawa Barat dianugerahi dengan potensi wisata alam dan budaya. Sumbawa Barat memiliki keindahan dan memberikan peluang bagi industri pariwisata. Namun potensi tersebut belum dikelola secara optimal, sehingga kegiatan usaha pariwisata khususnya pemasaran produk belum menemukan formula yang tepat. Salah satu upaya yang perlu dilakukan adalah kemitraan dan kolaborasi para pemangku kepentingan pariwisata. Penelitian ini mengkaji seberapa besar pengaruh kemitraan pemangku kepentingan terhadap pemasaran paket wisata di Kabupaten Sumbawa Barat. Kemitraan pemangku kepentingan utama dipelajari dengan menggunakan pendekatan kuantitatif deskriptif dengan metode analisis data regresi berganda. Penelitian ini menemukan bahwa korelasi stakeholder dengan pemasaran paket wisata memiliki nilai sebesar 57,2%. Secara simultan stakeholder mempengaruhi pemasaran paket wisata secara signifikan sebesar 62,1%. Sedangkan variabel asosiasi pariwisata sebagai private stakeholder memiliki persentase pengaruh yang tinggi sebesar 46,6% terhadap pemasaran paket wisata.Kata kunci: Sumbawa Barat, Paket Wisata, Kemitraan.
Analyzing the Habitable Zones of Circumbinary Planets Using Machine Learning
Authors: Kong Zhihui , Jiang Jonathan H. , Burn Remo , Fahy Kristen A. , Zhu Zong-Hong 
Published: April 2022

Abstract
Exoplanet detection in the past decade by efforts including NASA’s Kepler and TESS missions has revealed many worlds that differ substantially from planets in our own solar system, including more than 150 exoplanets orbiting binary or multi-star systems. This not only broadens our understanding of the diversity of exoplanets, but also promotes our study of exoplanets in the complex binary systems and provides motivation to explore their habitability. In this study, we investigate the habitable zones of circumbinary planets (P-type) based on planetary trajectory and dynamically informed habitable zones. Our results indicate that the mass ratio and orbital eccentricity of binary stars are important factors affecting the orbital stability and habitability of planetary systems. Moreover, planetary trajectory and dynamically informed habitable zones divide planetary habitability into three categories: habitable, periodic habitable, and non-habitable. Therefore, we successfully train a machine-learning model to quickly and efficiently classify these planetary systems, which provides more useful constraints.
Radiation-induced D/H Exchange Rate Constants in Aliphatics Embedded in Water Ice
Authors: Qasim Danna , Hudson Reggie L. , Materese Christopher K. 
Published: April 2022

Abstract
Gas-phase and solid-state chemistry in low-temperature interstellar clouds and cores leads to a D/H enhancement in interstellar ices, which is eventually inherited by comets, meteorites, and even planetary satellites. Hence, the D/H ratio has been widely used as a tracer for the origins of extraterrestrial chemistry. However, the D/H ratio can also be influenced by cosmic rays, which are ubiquitous and can penetrate even dense interstellar molecular cores. The effects of such high-energy radiation on deuterium fractionation have not been studied in a quantitative manner. In this study, we present rate constants for radiation-induced D-to-H exchange for fully deuterated small (1–2 C) hydrocarbons embedded in H2O ice at 20 K and H-to-D exchange for the protiated forms of these molecules in D2O ice at 20 K. We observed larger rate constants for H-to-D exchange in the D2O ice versus D-to-H exchange in H2O ice, which we have attributed to the greater bond strength of C–D versus C–H. We find that the H-to-D exchange rate constants are smaller for protiated methane than ethane, in agreement with bond energies from the literature. We are unable to obtain rate constants for the unsaturated and reactive hydrocarbons ethylene and acetylene. Interpretation of the rate constants suggest that D/H exchange products are formed in abundance alongside radiolysis products. We discuss how our quantitative and qualitative data can be used to interpret the D/H ratios of aliphatic compounds observed throughout space.
Magnetization of Relativistic Current-carrying Jets with Radial Velocity Shear
Authors: Król Dominika Ł. , Stawarz Łukasz , Begelman Mitchell C. , Martí José-María , Perucho Manel , Petrenko Bohdan A. 
Published: April 2022

Abstract
Astrophysical jets, launched from the immediate vicinity of accreting black holes, carry away large amounts of power in a form of bulk kinetic energy of jet particles and electromagnetic flux. Here we consider a simple analytical model for relativistic jets at larger distances from their launching sites, assuming a cylindrical axisymmetric geometry with a radial velocity shear, and purely toroidal magnetic field. We argue that as long as the jet plasma is in magnetohydrostatic equilibrium, such outflows tend to be particle dominated, i.e., the ratio of the electromagnetic to particle energy flux, integrated over the jet cross-sectional area, is typically below unity, σ < 1. At the same time, for particular magnetic and radial velocity profiles, magnetic pressure may still dominate over particle pressure for certain ranges of the jet radius, i.e., the local jet plasma parameter β
pl < 1, and this may be relevant in the context of particle acceleration and production of high-energy emission in such systems. The jet magnetization parameter can be elevated up to the modest values of

σ
≲

(
10
)

only in the case of extreme gradients or discontinuities in the gaseous pressure, and a significantly suppressed velocity shear. Such configurations, which consist of a narrow, unmagnetized jet spine surrounded by an extended, force-free layer, may require an additional poloidal field component to stabilize them against current-driven oscillations, but even this will not substantially elevate their σ parameter.
The Diverse Shapes of Dwarf Planet and Large KBO Phase Curves Observed from New Horizons
Authors: Verbiscer Anne J. , Helfenstein Paul , Porter Simon B. , Benecchi Susan D. , Kavelaars J. J. , Lauer Tod R. , Peng Jinghan , Protopapa Silvia , Spencer John R. , Stern S. Alan , Weaver Harold A. , Buie Marc W. , Buratti Bonnie J. , Olkin Catherine B. , Parker Joel , Singer Kelsi N. , Young Leslie A. ,   The New Horizons Science Team
Published: April 2022

Abstract
Observing dwarf planets and other large Kuiper Belt objects (KBOs) from vantage points between 8 and 47 au from the Sun, NASA’s New Horizons spacecraft has found diversity in the shapes of their solar phase curves. Here we extend solar phase angle coverage of dwarf planets (136199) Eris, (136472) Makemake, and (136108) Haumea; large KBOs (28978) Ixion, (50000) Quaoar, (307261) 2002 MS4, and (556416) 2014 OE394; and Neptune’s satellite Triton to phase angles as high as α = 94° using New Horizons data and fit the resulting solar phase curves to the Hapke photometric model. When accounting for sparse α sampling, these fits yield large uncertainties in the Hapke parameters; however, opposition effect parameters are generally well constrained and suggest a significant range of regolith maturation ages among these bodies. The expanded range in α enables evaluation of Bond albedos, phase integrals, rotation curves at high α, and comparisons of the surface scattering properties of these objects with those of others in the solar system. The dwarf planets with surface compositions dominated by hypervolatiles, Eris and Makemake, and Triton (a likely former KBO) have shallower solar phase curve slopes (i.e., lower phase coefficients, higher phase integrals, and Bond albedos) than objects with volatile-poor surfaces. The total amplitude of Haumea’s rotation curve at α = 48° is Δm = 0.6 ± 0.2 mag, nearly twice that of its rotation curve measured from Earth at low phase angles. Bond albedos range from 0.037 ± 0.007 for Ixion to

0.99

−
0.09

+
0.01

for Eris.
Corps et représentation de soi dans les Lettres de Pline le Jeune
Authors: Blary Kévin 
Published: April 2022

Les travaux de Michel Foucault ont fait de la correspondance plinienne un des témoignages du tournant vers le « souci de soi », initié dès le début du iie siècle p.C. Cet article propose d’éclairer les constructions corporelles à l’œuvre dans la correspondance, au regard du processus de représentation de soi. Il réexamine l’ensemble des espaces privés de l’apprentissage et de la pratique du corps selon une nomenclature qualitative du corps en représentation suggérée par Pline le Jeune (mœurs, gestuelle, âge).
Sex Differences on the Concussion Clinical Profiles Screening in Adolescents With Sport-Related Concussion
Authors: Stephenson Katie , Womble Melissa N. , Frascoia Chelsea , Eagle Shawn R. , Covassin Tracey , Kontos Anthony P. , Collins Michael W. , Elbin R.J. 
Published: April 2022

Context
Sex differences influence symptom presentations after sport-related concussion and may be a risk factor for certain concussion clinical profiles.

Objective
To examine sex differences on the Concussion Clinical Profile Screen (CP Screen) in adolescents after sport-related concussion.

Design
Cross-sectional study.

Setting
A concussion specialty clinic.

Patients or Other Participants
A total of 276 adolescent (age = 15.02 ± 1.43 years; girls = 152 [55%]) athletes with a recently diagnosed concussion (≤30 days).

Main Outcome Measure(s)
The 5 CP Screen profiles (anxiety mood, cognitive fatigue, migraine, vestibular, ocular) and 2 modifiers (neck, sleep), symptom total, and symptom severity scores were compared using a series of Mann-Whitney U tests between boys and girls.

Results
Girls (n = 152) scored higher than boys (n = 124) on the cognitive fatigue (U = 7160.50, z = −3.46, P = .001) and anxiety mood (U = 7059, z = −3.62, P &lt; .001) factors but not on the migraine (U = 7768, z = −2.52, P = .01) factor. Girls also endorsed a greater number of symptoms (n = 124; U = 27233, z = −3.33, P = .001) and scored higher in symptom severity (U = 7049, z = −3.60, P &lt; .001) than boys.

Conclusions
Among adolescents, symptom endorsement on the CP Screen varied based on sex, and clinicians need to be aware of these differences, especially when evaluating postconcussion presentation in the absence of baseline data.
Radiobiological modeling of radiation-induced acute proctitis: A single-institutional study of prostate carcinoma
Authors: Singh Balbir , Singh Gaganpreet , Oinam Arun Singh , Singh Maninder , Kumar Vivek , Vashistha Rajesh , Sidhu Manjinder Singh , Katake Ajay 
Published: April 2022

ABSTRACT

Purpose:
To estimate the fitting parameters of the sigmoidal dose response (SDR) curve of radiation-induced acute proctitis in prostate cancer patients treated with intensity modulated radiation therapy (IMRT) for the calculation of normal tissue complication probability (NTCP).

Materials and Methods:
Twenty-five prostate cancer patients were enrolled and evaluated weekly for acute radiation-induced (ARI) proctitis toxicity. Their scoring was performed as per common terminology criteria for adverse events version 5.0. The radiobiological parameters namely n, m, TD50, and g50 were calculated from the fitted SDR curve obtained from the clinical data of prostate cancer patients.

Results:
ARI toxicity for rectum in carcinoma of prostate patients was calculated for the endpoint of acute proctitis. The n, m, TD50, and g50 parameters from the SDR curve of Grade 1 and Grade 2 acute proctitis are found to be 0.13, 0.10, 30.48 ± 1.52 (confidence interval [CI] 95%), 3.18 and 0.08, 0.10, 44.37 ± 2.21 (CI 95%), 4.76 respectively.

Conclusion:
This study presents the fitting parameters for NTCP calculation of Grade-1 and Grade-2 ARI rectum toxicity for the endpoint of acute proctitis. The provided nomograms of volume versus complication and dose versus complication for different grades of acute proctitis in the rectum help radiation oncologists to decide the limiting dose to reduce the acute toxicities.
Significance of Intercellular adhesion molecule-1 Lys496Glu gene polimorphism on plasma redox status regulation in laryngeal carcinoma
Authors: Yanar Karolin , Atayik Mehmet Can , Horozoğlu Cem , Demirkol Şeyda , Simsek Bahadir , Verim Aysegul , Küçükhüseyin Özlem , Aydın Seval , Yaylım İlhan , Çakatay Ufuk 
Published: April 2022

ABSTRACT

Background:
Intercellular adhesion molecule-1 (ICAM-1) is a surface glycoprotein important for tumor invasion and angiogenesis. The present research is conducted to investigate whether specific gene polymorphism of ICAM-1 K469E (rs5498) and plasma redox status could be associated with laryngeal cancer (LC) development. Since there is no clear evidence which investigates the relationship between ICAM-1 polymorphism and ROS-mediated plasma protein oxidation in LC, our study is the first significant contribution for investigating the relationship.

Methods:
The study covered patients with primary LC and their age-matched healthy control subjects. Evaluation of ICAM-1 K469E (rs5498) gene polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Plasma redox status was assessed with spectrophotometric methods.

Results:
In the current paper, we found that LC patients with GG genotype had a decreasing trend for the plasma oxidative damage biomarker levels when compared with all allele genotypes (AA and AG).

Conclusion:
We concluded that G allele of the ICAM-1 K469E gene plays a significant role in the optimal regulation of plasma redox homeostasis in patients with LC.
Expression of glucose transporter 1 (SLC2A1) – Clinicopathological associations and survival in an Indian cohort of colorectal cancer patients
Authors: Vasudevan Smreti , Mehta Anurag , Sharma Sanjeev Kumar , Sharma Anurag 
Published: April 2022

Background:
Glucose transporter 1 (GLUT1) facilitates the uptake of glucose in malignant cells. We investigated GLUT1 transcript expression in colorectal cancer (CRC) tumors and explored its relationship to clinicopathological features, diabetes condition, and patient survival.

Materials and Methods:
The expression of GLUT1 was determined using fluorescent probe-based quantitative real-time polymerase chain reaction assay of tumor tissue and corresponding normal mucosa from 180 archived formalin-fixed, paraffin-embedded tissue blocks of ninety upfront surgically resected colorectal adenocarcinoma cases. Clinical information was collected from the hospital medical records and statistical analyses were performed.

Results:
Compared to normal mucosa tissue, the GLUT1 expression was significantly elevated in CRC tumor tissue (0.024 ± 0.056 vs. 0.004 ± 0.005; P < 0.0001). The expression was significantly more in poorly differentiated tumors than well/moderately differentiated tumors (P = 0.024) and in patients with liver metastasis (P = 0.013). The high GLUT1 expression correlated with advanced tumor stage (P = 0.003), liver metastasis (P = 0.003), poor tumor differentiation (P = 0.02), and death (P = 0.001). In univariate Cox regression analysis for survival, high GLUT1 expression, presence of any comorbidity, diabetic condition, advanced or metastatic stage, and liver metastasis were significant risk factors for death. CRC patients with high GLUT1 expression showed worse survival outcomes than those with low GLUT1 expression (P = 0.001). Furthermore, the high GLUT1/diabetes (+) patients had an inferior survival outcome than the patients with low GLUT1/diabetes (+) condition.

Conclusions:

GLUT1 is significantly upregulated in colorectal adenocarcinoma. The expression correlated with poor tumor histology, higher stage, hepatic metastases, and adverse survival in the study cohort.
NURSES INTERVENTION STRATEGIES FOR HOSPITALISED PATIENTS WITH PRESSURE INJURIES IN HEALTHCARE FACILITIES IN ANAMBRA STATE, NIGERIA
Authors: Musa Kizito M , Nwankwo Clementina U , Silas Esther A , Ibekwe  Adaobi M 
Published: April 2022

Purpose: The study evaluated nurses’ intervention strategies for hospitalized patients with pressure injuries in healthcare facilities in Anambra State, Nigeria.
Methodology: Cross sectional design was used for the study. A convenient sampling technique was used to select 168 nurses from a population of 290 nurses. A self-structured questionnaire with Cronbach Alpha coefficient of 0.70 was used for data collection. Data obtained were summarized using descriptive statistics of frequency counts, percentages and mean scores.
Results: Findings from the study revealed that 70.2% of the nurses responses which gave an insignificant p-value (p>0.05) showed that nurses’ attitude towards pressure injury prevention in was poor. For nurses’ practice of pressure injury prevention, the p-value (p>0.05) was statistically insignificant as 65.5% of nurses never give advice to patients or caregivers regarding pressure injury preventive care before discharging the patient showing that pressure injury prevention was poor. Also 66.7% of nurses never carried out assessment procedures of pressure injury during treatment of patients with pressure injury and 80% of the nurses do proper documentation of pressure injury/wound characteristics. There was a significant relationship between nurses working experience and practices regarding pressure injury prevention; there was a relationship between nurses’ extent of treatment on patients with pressure injury and nurses’ rank but there was no significant relationship between nurses’ level of documentation of pressure injury and their level of education.
Recommendation: In-service training and refresher courses on pressure injury for nurses, implementation of hospital policies and guidelines to promote positive nurses’ attitude towards pressure injury prevention were recommended.
Effects of routine physical therapy with and without mirror therapy on phantom limb pain and psychosocial adjustment to amputation among prosthetic users
Authors: Noureen Ayesha , Ahmad Ashfaq , Fatima Arooj , Siddique Kashif , Abbas Zain Ul 
Published: April 2022

IntroductionThe study objective was to determine the effect of conventional physiotherapy treatment with and without mirror therapy on phantom limb pain and psychosocial adjustment to amputation among prosthesis wearers.MethodsIt was a randomized controlled trial. Data were collected in the Physiotherapy Department of the Pakistan Society for the Rehabilitation of the Disabled, Lahore, and University of Lahore teaching hospital, Lahore. Overall, 36 participants with unilateral lower extremity traumatic amputation and phantom limb pain were recruited.ResultsAt baseline, the experimental and control groups were comparable for both Numeric Pain Rating Scale (6.17 ± 1.80 and 6.33 ± 1.74) and psychosocial adjustment of the Trinity Amputation and Prosthesis Experience Scales, i.e. general adjustment (19.22 ± 2.39 and 19.67 ± 2.76), adjustment to limitation (12.78 ± 4.36 and 11.72 ± 3.69), and social adjustment (20.22 ± 1.83 and 20.05 ± 2.87). At the end of the 4th week, a significant reduction in pain was observed (2.27 ± 1.17 and 4 ± 1.37). Changes were recorded in general adjustment (22.27 ± 2.63 and 21.89 ± 2.21) and adjustment to limitation (19.67 ± 2.54 and 16.00 ± 3.97) but no significant difference was seen in social adjustment (22.67 ± 1.90 and 21.89 ± 1.99).ConclusionsMirror therapy combined with routine physical therapy is a beneficial approach and shows better results in mitigating phantom limb pain and in psychosocial adjustment to the prosthesis than routine physical therapy alone.
ĐẶC ĐIỂM LÂM SÀNG BỆNH NHÂN TĂNG TIẾT MỒ HÔI TAY CHÂN VÀ KẾT QUẢ THUỐC HB TRONG ĐIỀU TRỊ
Authors: Thị Thanh Tú Nguyễn , Tuyết Trang Nguyễn 
Published: April 2022

Mục tiêu: Mô tả một số đặc điểm lâm sàng bệnh nhân tăng tiết mồ hôi tay chân và đánh giá kết quả của thuốc HB trong điều trị. Phương pháp: Thử nghiệm lâm sàng trên 50 bệnh nhân tăng tiết mồ hôi tay chân, so sánh kết quả sau và trước điều trị. Kết quả: Độ tuổi trung bình là 24,02 ± 7,59 (tuổi), nữ nhiều hơn nam, tuổi khởi phát bệnh dưới 12 tuổi chiếm đa số (76%). Sau 1 tháng điều trị, bệnh nhân có tần suất ra mồ hôi mức độ luôn luôn là 40,0% giảm còn 16,0%, mức độ thường xuyên là 54,0% giảm còn 18,0% (p < 0,05). Mức tăng tiết mồ hôi ở độ 3 (50,0%) và độ 4 (16,0%) lần lượt giảm còn 12,0% và 4,0% (p < 0,05). Ảnh hưởng của tăng tiết mồ hôi tay chân tới chất lượng cuộc sống: có 16,0% số bệnh nhân giảm 80,0% triệu chứng bệnh và 58,0% số bệnh nhân giảm được 50,0% triệu chứng bệnh. Kết luận: Thuốc HB có tác dụng cải thiện các triệu trứng lâm sàng của bệnh nhân tăng tiết mồ hôi tay chân.
THỰC TRẠNG LO ÂU, TRẦM CẢM VÀ YẾU TỐ LIÊN QUAN Ở CÁC CẶP VỢ CHỒNG ĐIỀU TRỊ HIẾM MUỘN TẠI KHOA CHĂM SÓC SỨC KHỎE SINH SẢN TRUNG TÂM KIỂM SOÁT BỆNH TẬT TỈNH KIÊN GIANG NĂM 2021
Authors: Trần Nguyệt Quyên Lạc , Quang Huy Trần , Việt Dũng Trương 
Published: April 2022

Mục tiêu: Mô tả thực trạng lo âu, trầm cảm ở các cặp vợ chồng điều trị hiếm muộn tại khoa Chăm sóc sức khỏe sinh sản-Trung tâm Kiểm soát bệnh tật (CDC) tỉnh Kiên Giang năm 2021 và phân tích một số yếu tố liên quan. Phương pháp: Nghiên cứu mô tả cắt ngang có phân tích được thực hiện trên 770 đối tượng nghiên cứu (385 cặp vợ chồng) đang điều trị hiếm muộn tại Trung tâm chăm sóc sức khỏe sinh sản, CDC tỉnh Kiên Giang và được chọn vào nghiên cứu bằng phương pháp chọn mẫu thuận tiện. Số liệu được thu thập bằng phát vấn (tự điền) bộ câu hỏi DASS.21. Kết quả: Tỷ lệ lo âu ở người vợ cao hơn so với người chồng (46,2% so với 33,3%). Tỷ lệ trầm cảm ở người vợ và ở người chồng lần lượt là 17,7% và 10,06%. Lo âu và trầm cảm hầu hết ở mức độ nhẹ. Lo âu mức độ nặng và trầm cảm mức độ trung bình chỉ gặp ở người vợ và đều chiếm tỷ lệ nhỏ là 0,5% Yếu tố liên quan với tình trạng lo âu ở nhóm người vợ là ≥ 35 tuổi, tình trạng sống riêng (không ở với gia đình) và thời gian hiếm muộn ≥ 45 tháng (với OR lần lượt là 2,30, 3,75 và 1,74 lần). Yếu tố liên quan với tình trạng lo âu ở nhóm người chồng là tình trạng sống riêng (với OR = 2,2). Yếu tố duy nhất liên quan đến tình trạng trầm cảm ở nhóm người vợ là tình trạng sống riêng với OR = 2,2, trong khi ở nhóm người chồng các yếu tố liên quan đến trầm cảm bao gồm kinh tế khá giả, tình trạng sống riêng với OR tương ứng là 2,58 và 4,74. Kết luận: Tỷ lệ lo âu ở các cặp vợ chồng hiếm muộn là khá cao, tỷ lệ lo âu ở người vợ cao hơn rõ rệt so với người chồng (46,2% so với 33,5%). Tỷ lệ trầm cảm ở người vợ cũng cao hơn so với người chồng (17,7% so với 10,06%). Các yếu tố liên quan đến lo âu ở cặp vợ chồng hiếm muộn bao gồm: tuổi ≥ 35, tình trạng sống riêng, thời gian hiếm muộn, trong đó ở người chồng chỉ có yếu tố tình trạng sống riêng là liên quan có ý nghĩa thống kê. Các yếu tố liên quan đến trầm cảm ở cặp vợ chồng hiếm muộn bao gồm: kinh tế khá giả và sống riêng, trong đó ở người vợ chỉ có yếu tố sống riêng là liên quan có ý nghĩa thống kê.