bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poor and non-poor gap in under-five child nutrition: a case from Nepal using Blinder-Oaxaca decomposition approach
Authors: Bhusal Umesh Prasad 
Published: October 2022

Abstract
Introduction
Many low-and middle-income countries (LMICs) have improved health indicators in the past decades, however, there is a differential in outcomes between socioeconomic groups. Systematic analysis of drivers of child nutrition gap between non-poor and poor groups has a policy relevance in Nepal and other countries to make progress towards universal health coverage (UHC). The objective of this paper was to estimate the mean height-for-age z scores (HAZ) gap between under-five children belonging to non-poor and poor groups, divide the gap into components (endowments, coefficients and interaction), and identify the factors that contributed most to each of the component.

Methods
Information about 6277 under-five children was extracted from the most recent nationally representative Nepal Multiple Indicator Cluster Survey (MICS) 2019. HAZ was used to assess nutritional status of children. Wealth index was used to categorize children into non-poor and poor. Mean HAZ gap between groups was decomposed using Blinder-Oaxaca technique into components: endowments (group difference in levels of predictors), coefficients (group difference in effects of predictors), and interaction (group difference due to interaction between levels and effects of predictors). Detailed decomposition was carried out to identify the factors that contributed most to each component.

Results
There was a significant non-poor and poor gap in nutrition outcome measured in HAZ (0.447; p < 0.001) among under-five children in Nepal. The between-group mean differences in the predictors of study participants (endowments) contributed 0.210 (47%) to the gap. Similarly, the between-group differences in effects of the predictors (coefficients) contributed 0.308 (68.8%) towards the gap. The interaction contributed -0.071 (15.8%) towards minimizing the gap. The predictors/variables that contributed most towards the gap due to (i) endowments were: maternal education, province (Karnali, Sudurpaschim, Madhesh), residence (rural/urban), type of toilet facility and ethnic group (Dalit and Muslim); (ii) coefficients were: number of under-five children in family, ethnic group (Dalit and Muslim), type of toilet facility, maternal age and education.

Conclusion
Decomposition of the child nutrition gap revealed that narrowing the inequality between wealth groups depends not only on improving the level of the predictors (endowments) in the poor group but also on reducing differential effects of the predictors (coefficients).
Periostin: biology and function in cancer
Authors: Dorafshan Shima , Razmi Mahdieh , Safaei Sadegh , Gentilin Erica , Madjd Zahra , Ghods Roya 
Published: October 2022

AbstractPeriostin (POSTN), a member of the matricellular protein family, is a secreted adhesion-related protein produced in the periosteum and periodontal ligaments. Matricellular proteins are a nonstructural family of extracellular matrix (ECM) proteins that regulate a wide range of biological processes in both normal and pathological conditions. Recent studies have demonstrated the key roles of these ECM proteins in the tumor microenvironment. Furthermore, periostin is an essential regulator of bone and tooth formation and maintenance, as well as cardiac development. Also, periostin interacts with multiple cell-surface receptors, especially integrins, and triggers signals that promote tumor growth. According to recent studies, these signals are implicated in cancer cell survival, epithelial-mesenchymal transition (EMT), invasion, and metastasis. In this review, we will summarize the most current data regarding periostin, its structure and isoforms, expressions, functions, and regulation in normal and cancerous tissues. Emphasis is placed on its association with cancer progression, and also future potential for periostin-targeted therapeutic approaches will be explored.
Shoulder pain, shoulder disability, and depression as serial mediators between stress and health-related quality of life among middle-aged women
Authors: Oh Jihyun , Lee Myung Kyung 
Published: October 2022

Abstract
Background
This study analyzed the mediating effects of shoulder pain, disability, and depression on the relationship between stress and health-related quality of life among middle-aged women using a serial mediation model. Methods. Data on stress, health-related quality of life, shoulder pain, shoulder disability, and depression were collected from 565 women aged 35–64 years living in Seoul, South Korea, from May 13 to 23, 2021, using a self-reported, structured survey. SPSS PROCESS macro (Model 6) and serial mediation analysis were used to analyze the relationship between stress and health-related quality of life among participants, with shoulder pain, shoulder disability, and depression as mediators. Results. The results indicate that stress had a statistically direct impact on health-related quality of life. In the serial mediation analysis, shoulder pain, disability, and depression were found to be statistically significant, thus affecting the relationship between stress and health-related quality of life, with an explanatory power of 33%. Therefore, the relationship between stress and health-related quality of life was partially mediated by these variables. Conclusions. Thus, this study suggests the need for healthcare workers to develop methods, such as exercise intervention programs based on various degrees and types of physical activity, to improve health-related quality of life and reduce stress caused by shoulder pain, shoulder disability, and depression among middle-aged women.
Development and validation of an extended Cox prognostic model for patients with ER/PR+ and HER2− breast cancer: a retrospective cohort study
Authors: Xie Yiqun , Li Xizhou , Wu Ying , Cui Wenting , Liu Yang 
Published: October 2022

Abstract
Background
The purpose of this study was to explore a new estrogen receptor (ER) and/or progesterone receptor (PR)+ and human epidermal growth factor receptor 2 (HER2)− breast cancer prognostic model, called the extended Cox prognostic model, for determining the cutoff values for multiple continuous prognostic factors and their interaction via the new model concept and variable selection method.

Methods
A total of 335 patients with ER/PR+ and HER2− breast cancer were enrolled for the final analysis. The primary endpoint was breast cancer-specific mortality (BCSM). Prognostic factors (histological grade, histological type, stage, T, N, lymphovascular invasion (LVI), P53, Ki67, ER, PR, and age) were included in this study. The four continuous variables (Ki67, ER, PR, and age) were partitioned into a series of binary variables that were fitted in the multivariate Cox analysis. A smoothly clipped absolute deviation (SCAD) variable selection method was used. Model performance was expressed in discrimination and calibration.

Results
We developed an extended Cox model with a time threshold of 164-week (more than 3 years) postoperation and developed a user-friendly nomogram based on our extended Cox model to facilitate clinical application. We found that the cutoff values for PR, Ki67, and age were 20%, 60%, and 41–55 years, respectively. There was an interaction between age and PR for patients aged ≥ 41 years and PR ≥ 20% at 164-week postoperation: the older the patients with ER/PR+, HER2−, and PR ≥ 20% were, the lower the survival and more likely to recur and metastasize exceeding 164 weeks (more than 3 years) after surgery.

Conclusions
Our study offers guidance on the prognosis of patients with ER/PR+ and HER2− breast cancer in China. The new concept can inform modeling and the determination of cutoff values of prognostic factors in the future.
Epitope vaccine design for Toxoplasma gondii based on a genome-wide database of membrane proteins
Authors: Li Xuan-Wu , Zhang Ni , Li Zhuo-Lin , Dibo Nouhoum , Ma Zhen-Rong , Lu Bin , Huang Ye-Hong , Chang Yun-Feng , Chen Hong-Zhi , Wu Xiang 
Published: October 2022

Abstract
Background
There is presently no effective and safe vaccine for Toxoplasma gondii for humans. The study described here was designed to search for a novel group of optimal B cell and T cell epitopes from Toxoplasma membrane proteins using genome-wide comprehensive screening.

Methods
The amino acid sequences of membrane proteins of T. gondii were obtained from the UniProt database. The ABCPred and BepiPred servers were employed to predict the linear B cell epitopes. The Immune Epitope Database (IEDB) online service was utilized to forecast T cell epitopes within T. gondii membrane proteins that bind to human leukocyte antigen (HLA) class I (HLA-I) or HLA-II molecules.

Results
From the 314 membrane proteins of T. gondii, a total of 14 linear B cell epitopes embedded in 12 membrane proteins were identified. Eight epitopes for major histocompatibility complex (MHC) class I (MHC-I) molecules and 18 epitopes for MHC-II molecules were ultimately selected, for which world population coverage percentiles were 71.94% and 99.76%, respectively. The top rated combinations of linear B cell epitopes and T cell epitopes covering both BALB/c mice and a majority of the human population were identified for the development of a protective vaccine.

Conclusions
The ultimate vaccine construct described here, which comprises B cells, MHC-I and MHC-II epitopes, might protect individuals against T. gondii infection by inducing humoral and cellular immune responses.

Graphic abstract
Nerve entrapment syndromes of the upper limb: a pictorial review
Authors: Mangi Mohammad Danish , Zadow Steven , Lim WanYin 
Published: October 2022

AbstractPeripheral nerves of the upper limb may become entrapped at various points during their anatomical course. While physical examination and nerve conduction studies are the mainstay of diagnosis, there are multiple imaging options, specifically ultrasound and magnetic resonance imaging (MRI), which offer important information about the potential cause and location of nerve entrapment that can help guide management. This article overviews the anatomical course of various upper limb nerves, including the long thoracic, spinal accessory, axillary, suprascapular, radial, median, ulnar, and musculocutaneous nerves, and describes the common locations and causes of entrapments for each of the nerves. Common ultrasound and MRI findings of nerve entrapments, direct or indirect, are described, and various examples of the more commonly observed cases of upper limb nerve entrapments are provided.
Nonlinear analysis by applying best approximation method in p-vector spaces
Authors: Yuan George Xianzhi 
Published: October 2022

AbstractIt is known that the class ofp-vector spaces$(0 < p \leq 1)$(0<p≤1)is an important generalization of the usual norm spaces with rich topological and geometrical structure, but most tools and general principles with nature in nonlinearity have not been developed yet. The goal of this paper is to develop some useful tools in nonlinear analysis by applying the best approximation approach for the classes of 1-set contractive set-valued mappings inp-vector spaces. In particular, we first develop general fixed point theorems of compact (single-valued) continuous mappings for closedp-convex subsets, which also provide an answer to Schauder’s conjecture of 1930s in the affirmative way under the setting of topological vector spaces for$0 < p \leq 1$0<p≤1. Then one best approximation result for upper semicontinuous and 1-set contractive set-valued mappings is established, which is used as a useful tool to establish fixed points of nonself set-valued mappings with either inward or outward set conditions and related various boundary conditions under the framework of locallyp-convex spaces for$0 < p \leq 1$0<p≤1. In addition, based on the framework for the study of nonlinear analysis obtained for set-valued mappings with closedp-convex values in this paper, we conclude that development of nonlinear analysis and related tools for singe-valued mappings in locallyp-convex spaces for$0 < p \leq 1$0<p≤1seems even more important, and can be done by the approach established in this paper.
Exploring life engagement from the perspective of patients with major depressive disorder: a study using patient interviews
Authors: Therrien François , Meehan Stine R. , Weiss Catherine , Dine Jennifer , Brown T. Michelle , MacKenzie Erin M. 
Published: October 2022

Abstract
Background
Patient-reported outcomes can measure health aspects that are meaningful to patients, such as ‘life engagement’ in major depressive disorder (MDD). Expert psychiatrists recently identified ten items from the Inventory of Depressive Symptomatology Self-Report (IDS-SR) that can be used to measure patient life engagement. This study aimed to explore the concept of patient life engagement and provide support for the IDS-SR10 Life Engagement subscale from the patient perspective.

Methods
Semi-structured video interviews were conducted with adults with MDD in the United States. Patients were asked if they ever felt engaged with life, and how this affected their feelings, activities, socializing, and thoughts. Then, patients discussed the ten expert-selected IDS-SR items, and rated the relevance of all 30 items to patient life engagement on a 4-point scale.

Results
Patients (N = 20) understood the ‘engaged with life’ concept and could provide examples from their own lives, such as increased energy/motivation (100%), being more social/spending time with others (85%), being more communicative (80%), and having better mood (75%). Nineteen patients (95%) indicated that all ten IDS-SR10 Life Engagement items were relevant to patient life engagement, and nine of the ten items had a mean score ≥ 3 (moderately relevant). Four additional items (all relating to mood) also scored ≥ 3.

Conclusions
Patients found the concept of life engagement to be important and relatable, and confirmed the IDS-SR10 captures the defining non-mood-related aspects of patient life engagement. This research supports the relevance of patient life engagement as a potential clinical outcome beyond core mood symptoms, and the use of the IDS-SR10 Life Engagement subscale in patient-oriented research.
Self-reported health-related quality of life of the general population in Alberta, Canada during the COVID-19 pandemic
Authors: Wen Jiabi , Al Sayah Fatima , Simon Roland , Lahtinen Markus , Johnson Jeffrey A. , Ohinmaa Arto 
Published: October 2022

Abstract
Background
The COVID-19 pandemic has impacted various aspects of people’s life and wellbeing around the world. This study aimed to examine the impact of the COVID-19 pandemic on health-related quality of life (HRQL), measured by the EQ-5D-5L, amongst the general population in the province of Alberta, Canada, and explore whether the impact varied across population subgroups based on age, gender, and dwelling.

Methods
Data came from two waves of a repeated cross-sectional population-based survey, the COVID-19 Experiences and Impact Survey, administered by the Health Quality Council of Alberta. The first data collection (survey 1: n = 8790) was during May/June 2020 and the second (survey 2: n = 9263) during Oct 2020. We examined the comparability of weighted survey data and their representativeness to Alberta’s general population. We then explored between-survey differences in EQ-5D-5L index, EQ-VAS and dimension responses, and differences across subgroups within each survey. We compared HRQL of the pooled sample (survey 1&2) with the Alberta population norms data from the pre-pandemic period.

Results
Mean EQ-5D-5L index and EQ-VAS scores were 0.81 (0.15) and 72.54 (18.57), and 0.82 (0.14) and 71.98 (18.96) in surveys 1 and 2, respectively. The anxiety/depression dimension had the most reported problems (survey 1: 69.5%, survey 2: 70.2%). Respondents aged 16–24 or 75 and older, who identified themselves as a woman, or residing in urban areas had significantly lower EQ-5D-5L index scores compared to their counterparts in both surveys. Between-survey differences were not substantially different. Comparing the pooled sample with the pre-pandemic Alberta population norms, EQ-5D-5L index scores (0.82 vs. 0.84) and EQ-VAS scores (72.26 vs. 77.40) were significantly lower, and respondents aged 16–44, women, or urban residents were more impacted. More problems were reported in the anxiety/depression (69.9% vs. 37.2%) and usual activities dimensions (40.5% vs. 26.0%) during the pandemic period, especially for respondents aged 16–44, women, and those residing in urban areas.

Conclusions
Lower HRQL was reported during the COVID-19 pandemic compared to pre-pandemic HRQL in this population, with anxiety/depression and usual activities affected the most. People who were younger, women, and residing in urban areas were most impacted. The government responses to COVID-19 policies during population outbreaks should consider the needs of Albertans in these particular groups.
Deciphering the cytochrome P450 genes in the microbiome of a chronically polluted soil with history of agricultural activities
Authors: Salam Lateef Babatunde , Obayori Oluwafemi Sunday , Ilori Mathew Olusoji , Amund Olukayode Oladipo 
Published: October 2022

Abstract
Background
Cytochrome P450 monooxygenases (CYPs) are exciting biocatalysts that catalyzes diverse regio- and stereoselective reactions of a broad range of substrates. The cytochrome P450 genes (CYPomes) of a chronically polluted soil (3S) with history of agricultural activities were deciphered via functional annotation of putative ORFs (open reading frames) using KEGG KofamKOALA, PHMMER, the Cytochrome P450 Engineering Database CYPED v6.0, and the NCBI Batch Web CD-Search tool.

Results
Annotation revealed the detection of seventy-seven CYP families and eight standalone CYPs cutting across the three domains of life. The prokaryote CYPome has 72 CYP families, 93 subfamilies, and seven standalone CYPs. The phylum Proteobacteria and the genera Streptomyces, Mycobacterium, and Bacillus with 17, 16, 24, and 5 CYP families were predominant, while the domain Archaea was represented by CYP119A1. The phylum Cyanobacteria has two families, while 23 actinobacterial CYPs (other than Streptomyces and Mycobacterium) were also detected. The detected prokaryote CYPs are responsible for biodegradation of camphor, hydroxylation of monoterpene alcohols, biosynthesis of secondary metabolites, and hydroxylation of fatty acids and steroidal compounds. The eukaryote CYPome was represented by seven fungal CYPs (CYP505A3, CYP505B1, CYP51A, CYP51C, CYP55A1, CYP55A2, and CYP55A3) from Acremonium egyptiacum, Fusarium oxysporum, Aspergillus oryzae, Gibberella moniliformis, Aspergillus flavus, and Fusarium lichenicola, respectively, and CYP524A1 from the slime mold, Dictyostelium discoideum. The fungi CYPs were involved in biosynthesis of secondary metabolites, hydroxylation of fatty acids, and nitrate reduction and denitrification.

Conclusions
This study has established the diverse roles played by CYPs in soil, its implication for soil health and resilience, and its potentials for industrial application.
Validation of an Arabic translation of the Functional Mobility Assessment (FMA) tool for assistive mobility device users
Authors: Sarsak Hassan Izzeddin 
Published: October 2022

Abstract
Background
Functional mobility assessment (FMA) tool is a self-report questionnaire developed to measure users’ satisfaction with assistive mobility devices while performing activities of daily living.

Purpose
To validate an Arabic translation of the FMA tool for Arabic-speaking assistive mobility devices users.

Methods
A committee of 2 bilingual qualified occupational therapists translated the English version into Arabic which was verified by back translation. The final versions were administered to bilingual assistive mobility devices users. The participants were randomly assigned to answer either the English or Arabic version of the FMA first, followed by answering the FMA in the other language. The scores obtained were tested for agreement using the kappa statistic.

Results
Participants’ (n=52), 28 were males and 24 were females, average participant age was 39.4 years old and had used an assistive mobility device for 6.4 years. We found a significant moderate agreement between the scores obtained from the two versions (p<0.000). The kappa measurement of agreement was 0.59 (95% confidence interval, 0.48–0.70).

Conclusion
The FMA is now available in Arabic, and it is an appropriate measure for use in research and clinical practice to quantify satisfaction with a functional mobility among assistive mobility device users. Further studies should test its psychometric properties.
3D structural modelling and spectral decomposition analysis of Jay Field offshore Niger Delta, Nigeria
Authors: Akinwale Rotimi P. , Ayolabi Elijah , Akinwale Solomon A. 
Published: October 2022

AbstractIn the Niger Delta, the Jay Field offshore structural model and seismic attribute analysis were carried out to enhance prospect evaluation and mitigate risk in field development operations, especially in regions with few wells and poor seismic data. Integration of a 3D seismic cube and one well with composite logs was used to carry out this analysis. Horizon and fault mapping was enhanced with Seismic attribute analysis, and an optimum frequency for spectral decomposition was identified using spectral analysis. The 3D structural framework revealed collapsed crest structures and rollover anticlines which act as hydrocarbon traping systems on the field. Detailed spectral analysis was carried out before using the spectral decomposition attribute to identify the most suitable (spectral) frequency at which the possible reservoir zones become more pronounced. The spectral frequency of 25Hz has been analysed to give high amplitude in the hydrocarbon accumulated region (indicated around the well position). This was used to evaluate prospective regions. The spectral decomposition attribute analysis predicts regions of possible quality reservoirs. This paper reveals that seismic attributes such as spectral decomposition, energy, and similarity can improve reflection patterns in poor to good quality seismic data. In this paper, the energy and spectral decomposition are veritable attributes that have improved reflection patterns and had allowed to identify anomalous amplitude associated with hydrocarbon accumulation in this paper.
Multiple System Atrophy
Authors: Claassen Daniel O. 
Published: October 2022

ABSTRACT

PURPOSE OF REVIEW
Patients with multiple system atrophy (MSA) can present with diverse clinical manifestations, and the clinical care required is complex and requires a thoughtful approach to emerging symptoms and treatment decisions.

RECENT FINDINGS
Even though it is a rare disease, MSA is often encountered in clinical practice. New developments in biofluid biomarkers and diagnostic assessments offer potential for earlier and more accurate diagnosis. This article describes recent findings, such as the use of skin biopsies, neuroimaging, and novel treatment concepts (eg, central noradrenergic augmentation).

SUMMARY
MSA is a complex disease. This article provides a summary of treatment options for diverse symptoms that include autonomic, sleep, mood, and motor manifestations of the disease to help clinicians care for patients with MSA. Providing comprehensive care for patients with MSA requires an understanding of the diverse symptomatology that patients develop over time and should include an interdisciplinary team.