bluuebunny/crossref_metadata_2025_split huggingface dataset:
Music and Brain Circuitry: Strategies for Strengthening Evidence-Based Research for Music-Based Interventions
Authors: Chen Wen Grace , Iversen John Rehner , Kao Mimi H. , Loui Psyche , Patel Aniruddh Dhiren , Zatorre Robert J. , Edwards Emmeline 
Published: November 2022

The neuroscience of music and music-based interventions (MBIs) is a fascinating but challenging research field. While music is a ubiquitous component of every human society, MBIs may encompass listening to music, performing music, music-based movement, undergoing music education and training, or receiving treatment from music therapists. Unraveling the brain circuits activated and influenced by MBIs may help us gain better understanding of the therapeutic and educational values of MBIs by gathering strong research evidence. However, the complexity and variety of MBIs impose unique research challenges. This article reviews the recent endeavor led by the National Institutes of Health to support evidence-based research of MBIs and their impact on health and diseases. It also highlights fundamental challenges and strategies of MBI research with emphases on the utilization of animal models, human brain imaging and stimulation technologies, behavior and motion capturing tools, and computational approaches. It concludes with suggestions of basic requirements when studying MBIs and promising future directions to further strengthen evidence-based research on MBIs in connections with brain circuitry.SIGNIFICANCE STATEMENTMusic and music-based interventions (MBI) engage a wide range of brain circuits and hold promising therapeutic potentials for a variety of health conditions. Comparative studies using animal models have helped in uncovering brain circuit activities involved in rhythm perception, while human imaging, brain stimulation, and motion capture technologies have enabled neural circuit analysis underlying the effects of MBIs on motor, affective/reward, and cognitive function. Combining computational analysis, such as prediction method, with mechanistic studies in animal models and humans may unravel the complexity of MBIs and their effects on health and disease.
Anti‐hsa‐miR‐59 alleviates premature senescence associated with Hutchinson‐Gilford progeria syndrome in mice
Authors: Hu Qianying , Zhang Na , Sui Tingting , Li Guanlin , Wang Zhiyao , Liu Mingyue , Zhu Xiaojuan , Huang Baiqu , Lu Jun , Li Zhanjun , Zhang Yu 
Published: November 2022

AbstractHutchinson‐Gilford progeria syndrome (HGPS) is a lethal premature aging disorder without an effective therapeutic regimen. Because of their targetability and influence on gene expression, microRNAs (miRNAs) are attractive therapeutic tools to treat diseases. Here we identified that hsa‐miR‐59 (miR‐59) was markedly upregulated in HGPS patient cells and in multiple tissues of an HGPS mouse model (LmnaG609G/G609G), which disturbed the interaction between RNAPII and TFIIH, resulting in abnormal expression of cell cycle genes by targeting high‐mobility group A family HMGA1 and HMGA2. Functional inhibition of miR‐59 alleviated the cellular senescence phenotype of HGPS cells. Treatment with AAV9‐mediated anti‐miR‐59 reduced fibrosis in the quadriceps muscle, heart, and aorta, suppressed epidermal thinning and dermal fat loss, and yielded a 25.5% increase in longevity of LmnaG609G/G609G mice. These results identify a new strategy for the treatment of HGPS and provide insight into the etiology of HGPS disease.
A Golgi oxygen sensor controls intestinal mucin glycosylation
Authors: Hansson Gunnar C 
Published: November 2022

Intestinal mucin glycosylation is important for mucus‐bacterial homeostasis and is altered in disease. In this issue of The EMBO Journal, Ilani et al (2022) identify the Golgi enzyme quiescin sulfhydryl oxidase 1 (QSOX1) as a novel mucus regulator by controlling mucin sialylation.
Percepciones de la violencia, un análisis introspectivo sobre la experiencia de un grupo de militares colombianos
Authors: Trujillo Daniela , Salazar Manrrique Cindy Estefanía , Cardona Angarita Jorge 
Published: November 2022

La presente investigación, se enmarca en el campo de las ciencias sociales y tiene como objetivo primordial, identificar las afectaciones subjetivas y las respectivas prácticas de afrontamiento y resistencia que elaboran un grupo mujeres indígenas Makaguán de Fortul –Arauca, víctimas del conflicto armado en Colombia. Esta investigación se desarrolló a través de un lente teórico interseccional. En otras palabras, se analizó historias de vida atravesadas por hechos violentos en Colombia, desde una perspectiva de género, etnicidad y clase social. En términos metodológicos y epistémicos, esta investigación se construyó a partir de un abordaje hermenéutico/ cualitativo y decolonial, en donde se privilegió las voces y discursos de aquellas mujeres víctimas del conflicto armado en Colombia. Uno de los principales hallazgos de la investigación, hizo referencia al deseo de reintegración social a su resguardo de origen; territorio del cual fueron desplazadas y expulsadas hace una década. Producto del desplazamiento, las mujeres Makaguán y sus familias han sufrido afectaciones materiales, subjetivas y simbólicas que recuperten hasta el presente. Pese a que en el año 2018, la comunidad ganó una tutela interpuesta ante el Ministerio de Interior, aún no se han reintegrado a su resguardo de origen. Se han realizado varios intentos por restituir sus derechos, no obstante, no se ha logrado llegar a un consenso claro entre las autoridades del resguardo Cusay la Colorada en Fortul-Arauca, las mujeres desplazadas y la institucionalidad local (Alcaldía y Gobernación). En el presente año, nuevamente se están realizando acercamientos entre las partes involucradas, con el objetivo de restituir principios violados como los relacionados con el derecho a la vida, territorio, identidad cultural, autonomía y participación comunitaria. En, suma, se hace necesario atender, escuchar y gestionar la iniciativa de las mujeres Makaguán por volver a su resguardo, en aras de garantizar efectivamente la restitución de sus derechos fundamentales.
PROPUESTA DE SEGUIMIENTO DE LA LIMPIEZA DEL RÍO BOGOTÁ A PARTIR DE SUS SERVICIOS ECOSISTÉMICOS
Authors: Villegas Vargas Carolina 
Published: November 2022

A partir de la sentencia del río Bogotá del Consejo de Estado del año 2014, esta investigación propone un indicador para hacerle seguimiento a la recuperación de los servicios ecosistémicos del río, y de esta manera darle contexto biológico, social, cuantitativo y cualitativo a la sentencia. Para conocer el estado de los servicios ecosistémicos se diseñó una encuesta que evaluó 15 servicios ecosistémicos por medio de la escala de Likert del acuerdo, que fue aplicada a 266 personas adultas en dos lugares de la ribera del río: apenas éste llega a la ciudad conurbada y apenas sale de la ciudad. Entre los resultados más importantes se encuentra que la salud del ecosistema río Bogotá se deteriora al pasar por la urbe y recibir sus desechos, y, contrario a este resultado se encuentra que el beneficio de la naturaleza más valorado por la población encuestada fue cuidar de la naturaleza para las generaciones futuras. Un resultado optimista con respecto al futuro que más que certezas deja preguntas acerca de cómo en entornos deteriorados aparecen valores trascendentales que evocan un mundo en paz y en unidad con la naturaleza.
Kościół pomiędzy negacją a akceptacją świata
Authors: Dola Tadeusz 
Published: November 2022

Artykuł przedstawia problem relacji Kościoła do świata. Chrześcijanom stale towarzyszyła świadomość, że zostali posłani do świata, by głosić Ewangelię, co przynosiło w konsekwencji dążenie do przekształcania świata tak, by mogło się w nim urzeczywistniać królestwo Boże zapoczątkowane przez Chrystusa. Tak pojęta misja uczniów Chrystusa musiała wiązać się z angażowaniem się w otaczającą ich rzeczywistość w jej wymiarze społecznym, politycznym, kulturowym, ekonomicznym. Przedmiotem niniejszego przedłożenia było przedstawienie sposobu, w jaki chrześcijanie rozumieli i realizowali swój udział w kształtowaniu ludzkiego świata. W trakcie prowadzonych dociekań okazało się, że chrześcijanie zawsze stali i stoją także dziś wobec dylematu, który można nazwać: Kościół pomiędzy negacją a akceptacją świata. Wpływ na rozwikłanie tego dylematu miały głównie dwa czynniki. Pierwszym było oczekiwanie na koniec czasów, który miał nastąpić wraz z ostatecznym przyjściem królestwa Bożego. Ten motyw w kształtowaniu postawy chrześcijan wobec świata odgrywał rolę decydującą w pierwszych pokoleniach uczniów Chrystusa, choć i w wiekach późniejszych nie pozostawał bez znaczenia. Drugim był status prawny chrześcijaństwa przede wszystkim w Imperium Rzymskim, gdzie chrześcijaństwo najgłębiej zapuściło swoje korzenie i najszerzej się rozprzestrzeniało. Mając na względzie te wstępne założenia, została w artykule najpierw rozpatrzona kwestia nadziei chrześcijan na rychłe nadejście królestwa Bożego, co miało istotny wpływ na ich aktywność w doczesnym świecie. W kolejnym etapie rozważań przebadany został okres, w którym dokonała się radykalna zmiana statusu prawnego chrześcijaństwa w czasach Konstantyna Wielkiego i jego następców. Te przekształcenia w zasadniczy sposób zmieniły relację Kościoła do świata, a ukształtowana wtedy prawno-społeczna pozycja Kościoła zaważyła na całe wieki na sposobie obecności Kościoła w świecie. Konsekwencje przemian, dokonanych w erze konstantyńskiej, przetrwały właściwie do czasów współczesnych. Zbadanie tej kwestii stało się przedmiotem ostatniego punktu artykułu.
Fullness of Life in Mae Enga Traditional Religion and Christ the Life
Authors: Dlugosz Miriam Maria 
Published: November 2022

The Mae Enga are friendly, hospitable, strong of character and different from the other groups of Papua New Guinea. Through a brief reflection on the traditional world-view centered life and on evaluation of their concept of life, the study forms a foundation for dialogue and inculturation.
The material used in this article, beside the literature, is data collected during my research in 2020, via one-on-one interview (30 women and 30 men) and group discussions (10 women and 10 men) from two villages: Par and Yampu). A qualitative method was employed.
The findings of the research show that the whole life of the Mae Enga is oriented towards reciprocal relationships with the entire universe to experience abundant life here on earth, within one’s own clan community. Despite the socio-cultural changes that influence their values, beliefs and attitudes, the “life” remains the central value but the ways of obtaining life have changed. The traditional religion is giving space to Jesus Christ the Life, who takes Mae Engans “beyond” their own clan and offers to them a new identity as followers of Christ, Ktaisanya Tata (Tribe of Jesus Christ).
The presented reflection creates a space for dialogue between Christianity and culture. Jesus Christ enters the present Mae Enga socio-cultural reality in order to transform it, to offer a new identity and a new dimension in their search. In turn, the Mae Enga offer to the world the “Face of Christ” with its own cultural features and values, with its ways of worship and reconciliation.
Living Alone and Suicide Risk in the United States, 2008‒2019
Authors: Olfson Mark , Cosgrove Candace M. , Altekruse Sean F. , Wall Melanie M. , Blanco Carlos 
Published: November 2022

Objectives. To evaluate the association between living alone and suicide and how it varies across sociodemographic characteristics. Methods. A nationally representative sample of adults from the 2008 American Community Survey (n = 3 310 000) was followed through 2019 for mortality. Cox models estimated hazard ratios of suicide across living arrangements (living alone or with others) at the time of the survey. Total and sociodemographically stratified models compared hazards of suicide of people living alone to people living with others. Results. Annual suicide rates per 100 000 person-years were 23.0 among adults living alone and 13.2 among adults living with others. The age-, sex-, and race/ethnicity-adjusted hazard ratio of suicide for living alone was 1.75 (95% confidence interval = 1.64, 1.87). Adjusted hazards of suicide associated with living alone varied across sociodemographic groups and were highest for adults with 4-year college degrees and annual incomes greater than $125 000 and lowest for Black individuals. Conclusions. Living alone is a risk marker for suicide with the strongest associations for adults with the highest levels of income and education. Because these associations were not controlled for psychiatric disorders, they should be interpreted as noncausal. (Am J Public Health. 2022;112(12):1774–1782. https://doi.org/10.2105/AJPH.2022.307080 )
Micro-scale Patterns and Drivers of Bird Visitation on Street Fig Trees in Delhi, India
Authors: Rawal Prakhar , Chatrath Deepali , Shahabuddin Ghazala 
Published: November 2022

Abstract

Street trees have been used as a means of mitigating the negative effects of urbanization on biodiversity, particularly bird fauna. Despite their widely acknowledged benefits for birds, studies so far have been largely limited to relatively coarse scales, with an understanding of the role of local environments and individual tree characters lacking. We studied the patterns of bird visitation at individual street Ficus (fig) trees, providers of keystone resources in tropical landscapes, in Delhi, India, and their drivers at different scales (tree characteristics, local and landscape variables). Three common fig species were surveyed for bird visitors across 3 sites with varying urban patterns. Fig trees were found to be a relatively common street tree choice, and the 106 trees surveyed were visited by 29 bird species, including 7 obligate frugivores. We found that reducing green cover in surrounding landscape and increasing noise did not deter birds from visiting these trees. Instead, variables at finer scales like tree canopy diameter, tree species and local resource density had sizable and significant effects on both species richness and abundance of bird visitors. Our results highlight how bird assemblages, guilds and individual species respond differently to a range of ecological variables, and an understanding of these responses at different scales is useful for maximising the value of street trees for urban birds. Thus, coarse-scale studies can provide insights into bird diversity of city landscapes, but micro-scale studies are important in helping make fine scale management decisions, like selection of street trees.
Molecular epidemiology of pregnancy using omics data: advances, success stories, and challenges
Authors: Rahnavard Ali , Chatterjee Ranojoy , Wen Hui , Gaylord Clark , Mugusi Sabina , Klatt Kevin C , Smith Emily R 
Published: November 2022

Abstract
Multi-omics approaches have been successfully applied to investigate pregnancy and health outcomes at a molecular and genetic level in several studies. As omics technologies advance, research areas are open to study further. Here we discuss overall trends and examples of successfully using omics technologies and techniques (e.g., genomics, proteomics, metabolomics, and metagenomics) to investigate the molecular epidemiology of pregnancy. In addition, we outline omics applications and study characteristics of pregnancy for understanding fundamental biology, causal health and physiological relationships, risk and prediction modeling, diagnostics, and correlations.
Overarching goal: To detail the utility of multi-omics approaches in the study of pregnancy physiology and disease.
Correlation analysis between body composition, serological indexes and the risk of falls in the elderly
Authors: Zhang Kexin , Ju Yanmin , Yang Di , Cao Mengyu , Liang Hong , Leng Jiyan 
Published: November 2022

Abstract
Objective: To study the risk factors of falls and explore the correlation between body composition, serological indexes and the risk of falls in the elderly.
Method: This is a cross-sectional study. The subjects were inpatients ≥ 60 years old in the cadre ward of the first hospital of Jilin University. The following information was obtained from the past comprehensive geriatric assessment database of the cadre ward. The body composition of the patients was measured by Bioelectrical Impedience Analysis (BIA) using the Inbody S10 device (Biospace, Seoul, Korea). We assessed according to the internationally used fall risk assessment tool (FRA), ≤ 2 points are divided into low-risk group, 3 - 9 points are divided into medium-risk group, and ≥ 10 points are divided into high-risk group.
Results: There were significant differences among the three groups in age, educational background, weight, cognitive impairment, malnutrition, ability of daily living, depression, systolic blood pressure, lower limb moisture, fat free weight, arm girth, body cell mass, skeletal muscle mass, limb muscle, red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin (ALB), prealbumin (PA), anemia and hypoproteinemia (P< 0.05). Ordinal logistic regression analysis showed that, for each unit of decrease in educational background and hemoglobin, the probability of the fall risk increasing by one level is 7.64 times and 1.094 times higher than the original (OR= 7.64, 95%CI: 1.38 - 225.19, P= 0.027); (OR= 1.094, 95%CI: 0.102-11.693, P< 0.001), for each additional unit of age, cognitive impairment, malnutrition and right lower limb moisture, the probability of the fall risk increasing by one level is 13.531, 10.186, 2.936, 5.755 times higher than the original (OR= 13.531, 95%CI: 6.080-30.114, P< 0.001); (OR= 10.186, 95%CI: 3.854-26.924, P< 0.001); (OR= 2.936, 95%CI: 1.514-5.686, P= 0.001); (OR= 5.755, 95%CI: 1.775-18.672, P= 0.004).
Conclusion: Educational background, hemoglobin are significant protective factors, and age, cognitive impairment, malnutrition, right lower limb moisture are significant risk factors for falls in the elderly.
Distinct profiles of anhedonia and reward processing and their prospective associations with quality of life among individuals with mood disorders
Authors: Pizzagalli Diego , Whitton Alexis , Kumar Poornima , Treadway Michael , Rutherford Ashleigh , Ironside Manon , Foti Dan , Fitzmaurice Garrett , Du Fei 
Published: November 2022

Abstract

Leading professional health bodies have called for the wider adoption of Patient Reported Outcome Measures, such as quality of life, in research and clinical practice as a means for understanding why the global burden of depression continues to climb despite increased rates of treatment use. Here, we examined whether anhedonia – an often recalcitrant and impairing symptom of depression – along with its neural correlates, was associated with longitudinal changes in patient-reported quality of life among individuals seeking treatment for mood disorders. We recruited 112 participants, includingn = 80 individuals with mood disorders (58 unipolar, 22 bipolar) andn = 32 healthy controls (63.4% female). We assessed anhedonia severity along with two electroencephalographic markers of neural reward responsiveness (scalp-level ‘Reward Positivity’ amplitude and source-localized reward-related activation in the dorsal anterior cingulate cortex), and assessed quality of life at baseline, 3- and 6-month follow-up. Anhedonia emerged as a robust correlate of quality of life cross-sectionally and longitudinally among individuals with mood disorders. Furthermore, increased neural reward responsiveness at baseline was associated with greater improvements in quality of life over time, and this improvement was mediated by longitudinal improvements in anhedonia severity. Finally, differences in quality of life observed between individuals with unipolar and bipolar mood disorders were mediated by differences in anhedonia severity. Our findings indicate that anhedonia and its reward-related neural correlates are linked to variability in quality of life over time in individuals with mood disorders. Treatments capable of improving anhedonia and normalizing brain reward function may be necessary for improving broader health outcomes for individuals seeking treatment for depression. ClinicalTrials.gov identifier: NCT01976975
Correlation of serum sodium，serum potassium concentrations and their ratios with blood pressure in elderly patients
Authors: Li Gang , Li Jing , He Le 
Published: November 2022

Abstract
Background
Several studies have investigated the relationship between dietary or urine potassium and sodium and blood pressure, but few have evaluated the relationship between serum potassium or sodium and blood pressure. Therefore, we evaluated the association between serum potassium and sodium and blood pressure in an elderly Chinese population.
Methods
A total of 241 elderly patients admitted to Hebei General Hospital were consecutively enrolled. 150 patients were divided into hypertension group and 91 patients were divided into normal blood pressure group. Correlation analysis and multiple logistic regression were used to analyze the relationship between serum sodium, serum potassium and their ratio with blood pressure. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of serum sodium/potassium ratio for hypertension in this population.
Results
Serum potassium was negatively correlated with systolic blood pressure (r=-0.341, P < 0.001), serum sodium-to-potassium ratio was positively correlated with systolic blood pressure (r = 0.349, P < 0.001), and serum sodium was not significantly correlated with systolic blood pressure (r = 0.105, P < 0.001). Serum sodium/potassium concentration ratio (OR = 1.094, 95%CI 1.003–1.193, P = 0.043) was still an independent influencing factor of hypertension. The area under ROC curve of serum sodium-to-potassium ratio for predicting hypertension in elderly patients was 0.666 (95%CI 0.599–0.733, P < 0.001).
Conclusions
Serum potassium level is related to blood pressure in the elderly population, and serum sodium-to-potassium ratio is related to hypertension in the elderly patients, which is an independent risk factor for hypertension in this population.
Antimicrobial Profiles of Pathogenic Enteric Bacteria Isolated from Commensal Rodents and Cockroaches from Morogoro Region in Tanzania: An environmental vehicle for resistance transmission to human and animals
Authors: R Kimwaga. B. , Mzula Alexander , Mnyone Ladslaus.L 
Published: November 2022

Abstract
Background: Increase of antimicrobial resistance (AMR) is becoming the global health concern since it reduces the effectiveness of antimicrobials and threatening the health of human and animals. Rodents and cockroaches can play a significant role in the dissemination of resistance bacteria between the environment and humans. This study aimed at determining antimicrobial resistance profile of enteric bacteria isolated from cockroaches and house rats.
Methods: Cockroaches were manually trapped with surgical gloves and sealed in sterile plastic containers where by house rats were trapped with wire cages and transported to microbiology laboratory. Bacteria were isolated following standard Microbiological techniques and antimicrobial susceptibility testing was done using Kirby Bauer diffusion technique.
Results: A total of 159 isolates of three targeted bacterial species were isolated from the gut of 114 house rats and 57 cockroaches. Among isolated bacteria only 83 were subjected to antimicrobial susceptibility test, among the tested antimicrobials; Amoxicillin, Ciprofloxacin and Tetracycline showed the highest resistance. Moreover Multidrug-resistance (MDR) was also observed for 66.3%.
Conclusion: Therefore, necessary control measures need to be taken against the infestation of rodents and cockroaches around households so as to minimize transmission of pathogenic and resistance bacteria.