bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long non-coding RNA linc00921 suppresses tumorigenesis and epithelial-to-mesenchymal transition of triple-negative breast cancer via targeting miR-9-5p/LZTS2 axis
Authors: Zhang Jie , Zhang Lina , Wang Jianlong , Zhao Jing , Zhao Xuelian , Zhang Chunli , Han Peng , Geng Cuizhi 
Published: February 2022

AbstractTriple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. Dysregulation of long non-coding RNAs (lncRNAs) plays crucial roles in the initiation and progression of TNBC. In this study, we analyzed public GEO profiles to verify the key lncRNAs in TNBC. Linc00921 was selected for further study. Low expression of linc00921 was observed in 49 of 95 TNBC tissues. Low expression of linc00921 was correlated with poor postoperative disease-free survival (DFS) and overall survival (OS) of TNBC patients. Overexpression of linc00921 with lentivirus suppressed the proliferation, migration and invasion of TNBC cells. A luciferase reporter assay showed that linc00921 could sponge miR-9-5p in TNBC. Moreover, linc00921 and miR-9-5p occupied the same Argonaute-2 (Ago2) protein in TNBC cells. Leucine zipper tumor suppressor 2 (LZTS2) was recognized as a target gene of miR-9-5p, and thereby a linc00921/miR-9-5p/LZTS2 axis was identified in TNBC cells. Overexpression of linc00921 promoted nuclear export of β-catenin, neutralized its function, and subsequently promoted epithelial-to-mesenchymal transition (EMT) in TNBC. A xenograft tumor mouse model showed that the miR-9-5p inhibitor upregulates LZTS2 expression and induce nuclear export of β-catenin in TNBC. Thus, linc00921 upregulates LZTS2 by sponging miR-9-5p to suppress tumorigenesis and EMT of TNBC. Linc00921/miR-9-5p/LZTS2 axis may be a novel biomarker and therapeutic target for TNBC patients.
From Theory to Practice: An International Approach to Establishing Prehabilitation Programmes
Authors: Davis June F. , van Rooijen Stefan J. , Grimmett Chloe , West Malcom A. , Campbell Anna M. , Awasthi Rashami , Slooter Gerrit D. , Grocott Michael P. , Carli Franco , Jack Sandy 
Published: February 2022

Abstract
Purpose
This article focuses on the following:

The importance of prehabilitation in people with cancer and the known and hypothesised benefits.

Exploration of the principles that can be used when developing services in the absence of a single accepted model of how these services could be established or configured.

Description of approaches and learning in the development and implementation of prehabilitation across three different countries: Canada, the Netherlands and the United Kingdom, based on the authors’ experiences and perspectives.

Recent Findings
Practical tips and suggestions are shared by the authors to assist others when implementing prehabilitation programmes. These include experience from three different approaches with similar lessons.
Important elements include the following: (i) starting with a small identified clinical group of patients to refine and test the delivery model and demonstrate proof of concept; (ii) systematic data collection with clearly identified target outcomes from the outset; (iii) collaboration with a wide range of stakeholders including those who will be designing, developing, delivering, funding and using the prehabilitation services; (iv) adapting the model to fit local situations; (v) project leaders who can bring together and motivate a team; (vi) recognition and acknowledgement of the value that each member of a diverse multidisciplinary team brings; (vii) involvement of the whole team in prehabilitation prescription including identification of patients’ levels of risk through appropriate assessment and need-based interventions; (viii) persistence and determination in the development of the business case for sustainable funding; (ix) working with patients ambassadors to develop and advocate for the case for support; and (x) working closely with commissioners of healthcare.

Summary
Principles for the implementation of prehabilitation have been set out by sharing the experiences across three countries. These principles should be considered a framework for those wishing to design and develop prehabilitation services in their own areas to maximise success, effectiveness and sustainability.
It is complicated: Potential short- and long-term impact of coronavirus disease 2019 (COVID-19) on antimicrobial resistance—An expert review
Authors: Seneghini Marco , Rüfenacht Susanne , Babouee-Flury Baharak , Flury Domenica , Schlegel Matthias , Kuster Stefan P. , Kohler Philipp P. 
Published: February 2022

Abstract
As of December 2021, the coronavirus disease 2019 (COVID-19) pandemic has claimed millions of deaths and caused disruptions in health systems around the world. The short- and long-term effects of COVID-19 on antimicrobial resistance (AMR), which was already a global threat before the pandemic, are manifold and complex. In this expert review, we summarize how COVID-19 might be affecting AMR in the short term (by influencing the key determinants antibiotic use, infection control practices and international/local mobility) and which additional factors might play a role in the long term. Whereas reduced outpatient antibiotic use in high-income countries, increased awareness for hand hygiene, and reduced mobility have likely mitigated the emergence and spread of AMR in the short term, factors such as overuse of antibiotics in COVID-19 patients, shortage of personal protective equipment, lack of qualified healthcare staff, and patient overcrowding have presumably facilitated its propagation. Unsurprisingly, international and national AMR surveillance data for 2020 show ambiguous trends. Although disruptions in antibiotic stewardship programs, AMR surveillance and research might promote the spread of AMR, other developments could prove beneficial to the cause in the long term. These factors include the increased public awareness for infectious diseases and infection control issues, the strengthening of the One Health perspective as outlined by the Centers for Disease Control and Prevention, and the unprecedented number of international research collaborations and platforms. These factors could even serve as leverage and provide opportunities to better combat AMR in the future.
Association between duration of antipseudomonal beta-lactam therapy and Clostridioides difficile infections in monomicrobial Enterobacterales bloodstream infections at an academic medical center
Authors: Hawkins Audry M. , Raux Brian , Weeda Erin , Hornback Krutika Mediwala 
Published: February 2022

Abstract

Objective:
To evaluate the effects early de-escalation of antipseudomonal β-lactam (APBL) on 90-day CDI risk in Enterobacterales bloodstream infections (BSIs).

Design:
Retrospective cohort analysis.

Setting:
An academic medical center in South Carolina.

Patients:
We included patients aged >18 years with monomicrobial BSIs with Enterobacterales who received APBL between July 1, 2015, and June 30, 2020.

Methods:
Rates of CDI were compared between patients who received an APBL for >72 hours and <72 hours, followed by comparison between formulary APBLs utilized.

Results:
In total, 447 patients were included; 292 and 155 patients received APBL for < 72 hours and > 72 hours, respectively. The incidences of CDI for <72 hours compared to >72 hours were 2.4% and 6.5%, respectively (unadjusted hazard ratio [HR], 2.70; 95% confidence interval [CI], 1.03–7.10; P = .04). This difference was not statistically significant in the adjusted model (HR, 2.66; 95% CI, 0.97–7.31; P = .06). Meropenem was associated with an increased risk of CDI when compared with all other formulary APBLs: 4 (26.7%) of 15 versus 13 (3.0%) of 432 (P < .001).

Conclusions:
Utilization of an APBL for >72 hours was associated with a statistically significant increase in the incidence of CDI in an unadjusted model and with a numerically higher CDI incidence in the adjusted model. Meropenem was the formulary APBL that carried the highest risk of CDI. The results of this study provide further evidence supporting active antimicrobial stewardship to reduce unnecessary broad-spectrum antibiotics in the effort to alleviate the burden that CDI imposes on the healthcare system.
Influence of critically appraising exemption requests from healthcare personnel along a spectrum of influenza vaccine hesitancy
Authors: Eby Joshua C. , Richey Morgan M. , Sifri Costi D. , Schuch Jonathon Z. 
Published: February 2022

AbstractObjectives:This study was performed to assess whether an intervention for critically appraising influenza vaccine exemption requests from healthcare personnel (HCP) affected (1) the overall rate of influenza vaccine exemption within a healthcare institution and/or (2) the rates of postintervention vaccine acceptance among those who inconsistently request exemption from annual vaccination and those who consistently request exemption from vaccination.Design:Retrospective, before-and-after intervention study.Setting:We conducted the study at a single academic medical center.Participants:This study included 29,663 HCP.Methods:Between 2010 and 2019, HCP were permitted to request an exemption from influenza vaccination without critical appraisal of exemption requests. After January 2019, medical center policy required critical appraisal of exemption requests. Of those employed 3 or more years who requested an exemption at least once during the preintervention period (n = 1,177), those with unchanging exemption reasons annually were termed “consistent exempters.” Those who changed reasons or accepted vaccination n ≥ 1 times were termed “inconsistent exempters.”Results:The overall exemption rate from influenza vaccine decreased from 3.8% to 1.2% (P < .001; N = 29,663) after the intervention. Of those requesting exemption at least once before the intervention, 329 (28.0%) of 1,177 were consistent exempters and 878 (72.0%) were inconsistent exempters. Of inconsistent exempters employed after the intervention, 442 (88.9%) of 497 accepted vaccine postintervention compared with 118 (59.6%) of 198 consistent exempters (P < .001). Of all exempters who changed from exemption to acceptance after the intervention, 442 (78.9%) of 560 were inconsistent exempters.Conclusions:Critical appraisal of HCP exemption requests promotes influenza vaccine acceptance, and acceptance by inconsistent exempters drives the effect of the intervention. Analysis of changes in annual exemption requests represents a novel objective method for describing those on the spectrum of vaccine hesitancy.
A cross-sectional analysis of psychological distress among higher education students in Ireland
Authors: Cullinan J. , Walsh S. , Flannery D. , Kennelly B. 
Published: February 2022

AbstractObjectives:To examine levels of psychological distress among higher education students in Ireland overall and across a range of personal, higher education, and socioeconomic characteristics, prior to the COVID-19 pandemic.Methods:A cross-sectional online survey of college students in Ireland was undertaken in 2018. Data on 5201 students from 13 higher education institutions (HEIs) were analyzed. Stress, anxiety, and depression symptom scores based on the Depression, Anxiety and Stress Scale (DASS-21) were calculated and reported, with statistical testing used to compare across groups.Results:Overall, 29.6% and 19.1% of respondents were classified in the mild to moderate and severe to extremely severe range for depression respectively. The corresponding proportions were 25.9% and 20.7% for anxiety, and 24.5% and 14.8% for stress. Differences across groups included higher levels of psychological distress for transgender and female students compared to males (p < 0.01), for gay/lesbian/bisexual students compared to heterosexuals (p < 0.01), for undergraduates compared to postgraduates (p < 0.01), for students from intermediate/technical/service/unskilled social classes compared to professional/self-employed social classes (p < 0.01), and for those with financial difficulties compared to those without financial difficulties (p < 0.01).Conclusions:Rates of psychological distress were high amongst college students in Ireland prior to the COVID-19 pandemic, with substantial differences across groups. Due to study limitations, such as possible selection bias, the findings need replication. Further research is needed to determine the impact of the pandemic on the prevalence of mental illness in this population.
Empirical glacier mass-balance models for South America
Authors: Mutz Sebastian G. , Aschauer Johannes 
Published: February 2022

AbstractWe investigate relationships between synoptic-scale atmospheric variability and the mass-balance of 13 Andean glaciers (located 16–55° S) using Pearson correlation coefficients (PCCs) and multiple regressions. We then train empirical glacier mass-balance models (EGMs) in a cross-validated multiple regression procedure for each glacier. We find four distinct glaciological zones with regard to their climatic controls: (1) The mass-balance of the Outer Tropics glaciers is linked to temperature and the El Niño-Southern Oscillation (PCC ⩽ 0.6), (2) glaciers of the Desert Andes are mainly controlled by zonal wind intensity (PCC ⩽ 0.9) and the Antarctic Oscillation (PCC ⩽0.6), (3) the mass-balance of the Central Andes glaciers is primarily correlated with precipitation anomalies (PCC ⩽ 0.8), and (4) the glacier of the Fuegian Andes is controlled by winter precipitation (PCC ≈ 0.7) and summer temperature (PCC ≈ −0.9). Mass-balance data in the Lakes District and Patagonian Andes zones, where most glaciers are located, are too sparse for a robust detection of synoptic-scale climatic controls. The EGMs yieldR2values of ~ 0.45 on average and ⩽ 0.74 for the glaciers of the Desert Andes. The EGMs presented here do not consider glacier dynamics or geometry and are therefore only suitable for short-term predictions.
Discounted probability of exponential parisian ruin: Diffusion approximation
Authors: Liang Xiaoqing , Young Virginia R. 
Published: February 2022

AbstractWe analyze the discounted probability of exponential Parisian ruin for the so-called scaled classical Cramér–Lundberg risk model. As in Cohen and Young (2020), we use the comparison method from differential equations to prove that the discounted probability of exponential Parisian ruin for the scaled classical risk model converges to the corresponding discounted probability for its diffusion approximation, and we derive the rate of convergence.
INITIAL SEGMENTS OF THE DEGREES OF CEERS
Authors: ANDREWS URI , SORBI ANDREA 
Published: February 2022

AbstractIt is known that every non-universal self-full degree in the structure of the degrees of computably enumerable equivalence relations (ceers) under computable reducibility has exactly one strong minimal cover. This leaves little room for embedding wide partial orders as initial segments using self-full degrees. We show that considerably more can be done by staying entirely inside the collection of non-self-full degrees. We show that the poset can be embedded as an initial segment of the degrees of ceers with infinitely many classes. A further refinement of the proof shows that one can also embed the free distributive lattice generated by the lower semilattice as an initial segment of the degrees of ceers with infinitely many classes.
MUTUAL INTERPRETABILITY OF WEAK ESSENTIALLY UNDECIDABLE THEORIES
Authors: DAMNJANOVIC ZLATAN 
Published: February 2022

AbstractKristiansen and Murwanashyaka recently proved that Robinson arithmetic, Q, is interpretable in an elementary theory of full binary trees, T. We prove that, conversely, T is interpretable in Q by producing a formal interpretation of T in an elementary concatenation theory QT+, thereby also establishing mutual interpretability of T with several well-known weak essentially undecidable theories of numbers, strings, and sets. We also introduce a “hybrid” elementary theory of strings and trees, WQT*, and establish its mutual interpretability with Robinson’s weak arithmetic R, the weak theory of trees WT of Kristiansen and Murwanashyaka, and the weak concatenation theory WTCε of Higuchi and Horihata.
The Water of Life and Death: A Brief Economic History of Spirits
Authors: Cockx Lara , Meloni Giulia , Swinnen Johan 
Published: February 2022

AbstractSpirits represent around 50% of global alcohol consumption. This sector is much less studied than other alcoholic beverages such as wine or beer. This paper reviews the economic history of spirits and analyzes recent trends in the spirits markets. The technology to produce spirits is more complex than for wine or beer. Distillation was known in ancient Chinese, Indian, Greek, and Egyptian societies, but it took innovations by the Arabs to distill alcohol. Initially, this alcohol was used for medicinal purposes. Only in the Middle Ages did spirits become a widespread drink. The Industrial Revolution created a large consumer market and reduced the cost of spirits, contributing to excess consumption and alcoholism. Governments have intervened extensively in spirits markets to reduce excessive consumption and to raise taxes. There have been significant changes in spirits consumption and trade over time. Over the past 50 years, the share of spirits in global alcohol consumption increased from around 30% to around 50%. In the past decades, there was strong growth in emerging markets, including in China and India. Recent developments in the spirits industry include premiumization, the growth of craft spirits, and the introduction of terroir for spirits. (JEL Classifications: L51, L66, N40, Q11, Q18)
SOIL ORGANIC CARBON DATING OF PALEOSOILS OF ALLUVIAL FANS IN A BLOWN SAND AREA (NYÍRSÉG, HUNGARY)
Authors: Buró Botond , Négyesi Gábor , Varga Tamás , Sipos György , Filyó Dávid , Jull A J Timothy , Molnár Mihály 
Published: February 2022

ABSTRACTThe most widely used dating techniques in quaternary research are the radiocarbon (14C) and optically stimulated luminescence (OSL) dating methods. In some environments, the investigated sediments do not contain enough material for14C dating. In these cases,14C dating of bulk sediment may be used as a last resort. The major aim of the present study was to determine the reliability and limitations of the different fractions of the soil organic carbon (SOC)14C ages in the Nyírség blown-sand study area, in Hungary. Therefore, the low- and high-temperature combustions of SOC (LT-SOC and HT-SOC)14C age of fossil soils were compared with the charcoal ages from the same fossil soil layer, and their (LT-SOC, HT-SOC, and charcoal) age reliability was verified independently by applying OSL to the quartz fraction of the sediment samples. The14C data show variable agreement with OSL ages. Charcoal fragments were collected from some of the best material for14C dating and their ages are in agreement with the LT and HT-SOC14C ages and OSL data. The14C age LT-SOC gives a reliable, credible ages, which were confirmed by independent OSL measurements. If buried soils do not contain any other macroscopic remnants for14C dating, the LT-SOC14C ages can be used, in the case of the Nyírség study area. The LT-SOC, which is the younger fraction of the soil organic carbon, may be considered to represent the burial time of the fossil soil layer. The HT-SOC14C ages are sometimes unrealistically older than expected and cannot be considered to be reliable.
Histories of Empire and Environmental Legacies in Africa
Authors: Peša Iva 
Published: February 2022

AbstractSocietal debates about climate change have rekindled interest in environmental history approaches. This review article considers three recent books in African environmental history, on the Kruger National Park, the East African Groundnut Scheme, and on infrastructure in postcolonial Dar es Salaam. Why is it important to study the empire–environment nexus? How do African experiences relate to discussions on the Anthropocene? Taking environmental dynamics into account enriches understandings of social, political, and cultural relationships and sheds light on imperialism and its complex legacies. This article makes the case for the importance of environmental history as a category of analysis, encouraging other scholars to think “with” the environment in broader debates concerning power, identity, and social change.
Eliciting uncertainty for complex parameters in model-based economic evaluations: quantifying a temporal change in the treatment effect
Authors: Jankovic Dina , Payne Katherine , Kanaan Mona , Bojke Laura 
Published: February 2022

Abstract

Background
In model-based economic evaluations, the effectiveness parameter is often informed by studies with a limited duration of follow-up, requiring extrapolation of the treatment effect over a longer time horizon. Extrapolation from short-term data alone may not adequately capture uncertainty in that extrapolation. This study aimed to use structured expert elicitation to quantify uncertainty associated with extrapolation of the treatment effect observed in a clinical trial.

Methods
A structured expert elicitation exercise was conducted for an applied study of a podiatry intervention designed to reduce the rate of falls and fractures in the elderly. A bespoke web application was used to elicit experts’ beliefs about two outcomes (rate of falls and odds of fracture) as probability distributions (priors), for two treatment options (intervention and treatment as usual) at multiple time points. These priors were used to derive the temporal change in the treatment effect of the intervention, to extrapolate outcomes observed in a trial. The results were compared with extrapolation without experts’ priors.

Results
The study recruited thirty-eight experts (geriatricians, general practitioners, physiotherapists, nurses, and academics) from England and Wales. The majority of experts (32/38) believed that the treatment effect would depreciate over time and expressed greater uncertainty than that extrapolated from a trial-based outcome alone. The between-expert variation in predicted outcomes was relatively small.

Conclusions
This study suggests that uncertainty in extrapolation can be informed using structured expert elicitation methods. Using structured elicitation to attach values to complex parameters requires key assumptions and simplifications to be considered.
The timescales of word learning in children with language delays: In-the-moment mapping, retention, and generalization
Authors: KUCKER Sarah C. , SEIDLER Erin 
Published: February 2022

AbstractLearning new words and, subsequently, a lexicon, is a time-extended process requiring encoding of word-referent pairs, retention of that information, and generalization to other exemplars of the category. Some children, however, fail in one or more of these processes resulting in language delays. The present study examines the abilities of children who vary in vocabulary size (including both children with normal language (NL) and late talking (LT) children) across multiple timescales/processes – known and novel word mapping, novel word retention, and novel noun generalization. Results indicate that children with lower language skills suffer from deficits in quick in-the-moment mapping of known words compared to their NL peers, but age and vocabulary size rather than normative vocabulary ranking or NL/LT status better predicts performance on retention and generalization processes. Implications for understanding language development as a holistic process with multiple interacting variables are discussed.