bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep reinforcement learning‐based ordering mechanism for performance optimization in multi‐echelon supply chains
Authors: Kurian Dony S. , Pillai V. Madhusudanan , Raut Akash , Gautham J. 
Published: October 2022

AbstractThe need for self‐adaptive and intelligent supply chain systems is essential to meet the challenges of the current global markets. Despite the recent breakthroughs in artificial intelligence, literature still lacks the application of state‐of‐the‐art methods to optimize the performance of supply chain ordering management problems. Thus, this paper proposes a relatively new Deep Reinforcement Learning‐based Ordering Mechanism (DRLOM) for multi‐echelon linear supply chain systems. Initially, the supply chain ordering management problem is formulated as an agent‐based reinforcement learning model and, afterwards, solved using a recently developed policy‐based algorithm called proximal policy optimization. The proposed approach (DRLOM) aids the assumed supply chain echelons, such as the Retailer, the Wholesaler, the Distributor and the Factory, to learn the optimal/near‐optimal dynamic strategies for inventory ordering systems. The experimental results also validate that the proposed approach efficiently minimizes the system‐wide total accumulated inventory costs under different problem instances than other ordering heuristics and evolutionary computation methods. Throughout this paper, benchmark findings from the literature are used to evaluate the performance of the proposed approach. Furthermore, limitations of the earlier works are addressed through this paper and contribute to the supply chain ordering management literature.
Bewertung der Nachweiskonzepte nach EC7 für Baugrubenwände in Sand auf Grundlage der Finite‐Elemente‐Methode
Authors: Seibel Elisabeth , Vrettos Christos , Hettler Achim 
Published: October 2022

AbstractDer aktuelle Entwurf der neuen Fassung der EN 1997 unterscheidet für numerische Berechnungen von Stützwänden zwischen Nachweisverfahren mit Ansatz der Teilsicherheitsfaktoren auf die resultierenden Beanspruchungen oder auf die Scherparameter des Bodens. Hierzu wurden umfassende numerische Studien auf Grundlage der Finite‐Elemente‐Methode für repräsentative Systemgeometrien durchgeführt und die Ergebnisse kritisch beurteilt. Systeme mit unterschiedlichen Randbedingungen hinsichtlich Stützung, Grundwasserstand, Baugrubentiefe und Einbindetiefe wurden betrachtet. Für alle Systeme wurden Schnittgrößen ermittelt. Insgesamt zeigte sich, dass beide Nachweismethoden ähnliche Werte für Querkräfte und Biegemomente entlang der Wand liefern. Es wurden die zwei Varianten für die Nachweismethode mit Abminderung der Scherparameter des Bodens verglichen; beide Varianten ergaben untereinander abweichende Ergebnisse aufgrund der unterschiedlichen Ausgangszustände mit einer A‐priori‐Abminderung der Scherparameter des Bodens einerseits und einer Abminderung nur in maßgebenden Berechnungsphasen andererseits. Ein Vergleich mit dem gängigen analytischen Verfahren nach Blum gemäß den Empfehlungen der EAB ergab, dass in der FEM aufgrund anderer Spannungsverteilungen entlang der Wand andere Einbindelängen erforderlich sind, um den Nachweis des Fußauflagers zu erfüllen. Die Einspannwirkung in den FEM‐Berechnungen fällt geringer aus, als dies bei einer analytischen Berechnung nach Blum der Fall ist.
Aktionsplan zur modellbasierten Baulogistikplanung – Die Implementierung BIM‐basierter Planungsmethoden in die Fachdisziplin Baulogistik erfordert Handlungsbedarf
Authors: Placzek Gerrit , Barking Lars , Troitzsch Hilmar , Schwerdtner Patrick 
Published: October 2022

AbstractSeit November 2020 haben sich die Zeppelin Rental GmbH und das Institut für Bauwirtschaft und Baubetrieb der TU Braunschweig in gemeinsamer Forschungsarbeit der Fragestellung gewidmet, wie sich baulogistische Planungsprozesse für Hochbauten durch die BIM‐Methode verändern und durch die Nutzung digitaler Bauwerksmodelle optimiert werden können. Auf Grundlage der erzielten Forschungsergebnisse ist Ende Juni 2022 dieser Aktionsplan entstanden. Der Plan sieht erforderliche Handlungsschritte vor, die zur Implementierung der modellbasierten Baulogistikplanung zu berücksichtigen sind.
Radio frequency ablation for the intrauterine treatment of giant placental chorioangioma associated with fetal compromise: A case report
Authors: Zhao Bingyi , Yin Lu , Chu Wei , Wang Fangna , Huo Ping , Gao Jian 
Published: October 2022

AbstractGiant placental chorioangiomas associated with fetal hyperdynamic circulation complications are rare to see. Here, we summarized a case of giant placental chorioangioma associated with fetal anemia and heart failure treated by radiofrequency ablation (RFA) combined with cordocentesis and intrauterine transfusion. The sonographic appearance of the placental chorioangioma was atypical which was isoechoic with unclear boundary. RFA was performed successfully at 27 weeks of gestation, when the chorioangioma has increased to 17.0 × 10.6 × 12.3 cm3. Unfortunately, intrauterine fetal demise was found on the first day after operation. After induction of labor, it was pathologically confirmed as placental chorioangioma.
A retrospective case series of electroconvulsive therapy in the management of depression and suicidal symptoms in adolescents
Authors: Chen Xiaolu , Fu Yixiao , Zou Qianhong , Zhang Yiting , Qin Xiaoyue , Tian Yu , Yan Yu , Chen Qibin , Zou Lei , Zhao Bangshu , Li Xiao 
Published: October 2022

AbstractObjectiveMajor depressive disorder (MDD) with suicidal symptoms is common in adolescents. Electroconvulsive therapy (ECT) is highly effective in the treatment of MDD. We have described its use and outcome in a case series of adolescents with depression and suicidal symptoms receiving ECT.MethodsWe analyzed 362 adolescents aged from 12 to 17 who had received ECT between year 2015 and 2021. A total of 278 subjects were found to meet the inclusion criteria, where depressive symptoms were assessed by HDRS and suicidal symptoms were assessed by HDRS item 3. Their sociodemographic, clinical, and treatment information were retrieved through these records for this study.ResultsThe mean ± SD age of subjects was 15.41 ± 1.50 years and male sex was 14.7% (n = 41). Comorbid diagnoses were present in 104 patients (37.4%). The ECT sessions ranged from 6 to 12 times. All the patients took antidepressants, with sertraline (n = 182; 65.5%) being the most widely used. Majority of patients also received benzodiazepines. ECT was significantly effective in adolescents with depression and suicidal symptoms in evaluation by HDRS, HDRS item 3, CGI‐S (p < .001) pre/post‐ECT. The response rate of MDD patients was 52%, with suicidal ideation (SI) at 49%, and 54% in MDD with suicide attempt (SA). The change of CGI‐S scores showed no significant differences between various subgroups of sex and comorbid (p>.05), but there were significant differences between subgroups of suicidal symptoms (p < .001). ECT was generally safe with subjective memory complaint (n = 189, 68.0%), headache (n = 150, 54.0%), body pain (n = 28, 10.1%), delirium (n = 95, 34.2%), and nausea (n = 31, 11.2%) as possible side effects following ECT.ConclusionIn this study, ECT was found to decrease depressive and suicidal symptoms in adolescents, and the side effect was acceptable. ECT showed better outcome for MDD with SA compared to MDD with SI.
Pitstop‐2 and its novel derivative RVD‐127 disrupt global cell dynamics and nuclear pores integrity by direct interaction with small GTPases
Authors: Liashkovich Ivan , Stefanello Sílvio Terra , Vidyadharan Reshma , Haufe Günter , Erofeev Alexander , Gorelkin Peter V. , Kolmogorov Vasilii , Mizdal Caren Rigon , Dulebo Alexander , Bulk Etmar , Kouzel Ian U. , Shahin Victor 
Published: October 2022

AbstractClathrin‐mediated endocytosis (CME) is an essential cell physiological process of broad biomedical relevance. Since the recent introduction of Pitstop‐2 as a potent CME inhibitor, we and others have reported on substantial clathrin‐independent inhibitory effects. Herein, we developed and experimentally validated a novel fluorescent derivative of Pitstop‐2, termed RVD‐127, to clarify Pitstop‐2 diverse effects. Using RVD‐127, we were able to trace additional protein targets of Pitstop‐2. Besides inhibiting CME, Pitstop‐2 and RVD‐127 proved to directly and reversibly bind to at least two members of the small GTPase superfamily Ran and Rac1 with particularly high efficacy. Binding locks the GTPases in a guanosine diphosphate (GDP)‐like conformation disabling their interaction with their downstream effectors. Consequently, overall cell motility, mechanics and nucleocytoplasmic transport integrity are rapidly disrupted at inhibitor concentrations well below those required to significantly reduce CME. We conclude that Pitstop‐2 is a highly potent, reversible inhibitor of small GTPases. The inhibition of these molecular switches of diverse crucial signaling pathways, including nucleocytoplasmic transport and overall cell dynamics and motility, clarifies the diversity of Pitstop‐2 activities. Moreover, considering the fundamental importance and broad implications of small GTPases in physiology, pathophysiology and drug development, Pitstop‐2 and RVD‐127 open up novel avenues.
A novel integrated biomarker index for the assessment of hematological responses in MPNs during treatment with hydroxyurea and interferon‐alpha2
Authors: Dam Marc J. B. , Pedersen Rasmus K. , Knudsen Trine A. , Andersen Morten , Ellervik Christina , Larsen Morten Kranker , Kjær Lasse , Skov Vibe , Hasselbalch Hans C. , Ottesen Johnny T. 
Published: October 2022

AbstractBackgroundConventional cytoreductive therapy for patients with chronic Philadelphia‐negative myeloproliferative neoplasms (MPNs) includes hydroxyurea (HU), interferon‐alpha2 (IFN), and anagrelide. HU is worldwide the most used cytoreductive agent, which lowers elevated blood cell counts within days in the large majority of patients. However, some patients may experience rebound cytosis when HU is reduced due to cytopenia, thereby potentially giving rise to fluctuating cell counts during therapy. Such rapid oscillations may be harmful and potentially elicit thrombosis. Treatment with IFN gradually lowers elevated cell counts within weeks and when the dosage is reduced, the cell counts do not rapidly increase but are sustained within the normal range in the large majority of patients. Conventional hematological response criteria are among others based upon single absolute cell count values and do not take into account the relative decreases toward normal for each cell count.Materials, Methods & ResultsUsing serial data from the Danish DALIAH trial, we herein describe a novel integrated biomarker index for the assessment of hematological and molecular (JAK2V617F) responses in patients with MPNs during treatment with IFN or HU.DiscussionThis novel tool convincingly displays the superiority of IFN versus HU in normalizing elevated cell counts. Our results need to be validated in larger studies but already now call for studies of the safety and efficacy of combination therapy during the initial treatment of patients with MPNs.
Hsa_circ_0001445 works as a cancer suppressor via miR‐576‐5p/SFRP1 axis regulation in ovarian cancer
Authors: Wu Yuhong , Zhou Jinhua , Li Yan , Shi Xiu , Shen Fangrong , Chen Mingwei , Chen Youguo , Wang Juan 
Published: October 2022

AbstractBackgroundOvarian cancer (OC) has high mortality and morbidity. Circular RNA (circRNA) can deeply impact the tumor occurrence and growth. The pathogenic activity of one particular circRNA, hsa_circ_0001445 (hcR1445), in OC remains unclear and was therefore analyzed in this study.MethodsHuman OC tissue specimens and cell lines (SKOV3, HO8910, and OVCAR8) were used to examine the levels of hcR1445 and the microRNA miR‐576‐5p using polymerase chain reaction. The 5‐ethynyl‐2′‐deoxyuridine, flow cytometry, cellular scratch test, CCK‐8, and Transwell migration assays were used to examine the biological activities of hcR1445 and miR‐576‐5p on cell apoptosis, invasion, migration, and proliferation in OC cells. Protein expression of WNT/β‐catenin and secreted frizzled‐related protein 1 (SFRP1) were tested using Western blot analysis. The potential interactions of miR‐576‐5p/SFRP1 and hcR1445/miR‐576‐5p were evaluated using a dual‐luciferase report assay. The effect of hcR1445 on OC growth and metastasis was further determined using an OC tumor xenograft model in vivo.ResultshcR1445 level was declined in OC cells and tissues. hcR1445 reduced cellular invasion, proliferation, and migration by blocking the ability of miR‐576‐5p to upregulate SFRP1 expression and consequently prohibit WNT/β‐catenin signal transduction. hcR1445 upregulation suppressed OC growth, development, and intraperitoneal metastasis in vivo.ConclusionhcR1445 acts an antioncogene by targeting the miR‐576‐5p/SFRP1 axis and blocking OC progression and development. Thus, hcR1445 may be employed as an indicator or a possible therapeutic target in OC patients.
Commercial sexual exploitation of children in Zimbabwe: A threat to human and social development
Authors: Murewanhema Grant , Gwinji Phanuel Tawanda , Gwanzura Chipo , Chitungo Itai , Eghtessadi Rouzeh , Musuka Godfrey , Dzinamarira Tafadzwa 
Published: October 2022

AbstractCommercial sexual exploitation of children (CSEC) in child sex work is reportedly rising in Zimbabwe. While children of both sexes are affected, more females than males are forced to engage in sexual acts in exchange for money, food, access to shelter, education or some other gains from adults who control these means of survival and commodities. Drivers of CSEC include socioeconomic factors, negative peer pressure, childhood abuse, the influence of uncensored social media, and, more recently, the economic impact of COVID‐19. Involvement in underage sex work exposes children to severe adversities, such as psychosocial and mental health disorders, physical and biological injuries, venereal diseases and HIV. CSEC is a growing concern for resource‐limited countries, disenfranchises children and robs particularly the girl child of a better future. The worsening socioeconomic landscape in Zimbabwe and the COVID‐19 pandemic have exacerbated the problem. Solving the problem of CSEC requires a multipronged approach that involves stakeholders from several sectors, including public health, education, social services, security and the legal fraternity. There is a need to empower communities, empower civil society and development partners, enhance legal frameworks, provide messaging, education and vocational training, as well as rehabilitative services for affected children and their families. CSEC is a violation of the child's rights and a public health concern that needs to be addressed as a matter of urgency to preserve the next generation's human capital necessary for the sustainable development of Zimbabwe.
Enzymatic Late‐Stage Halogenation of Peptides
Authors: Schnepel Christian , Moritzer Ann‐Christin , Gäfe Simon , Montua Nicolai , Minges Hannah , Nieß Anke , Niemann Hartmut H. , Sewald Norbert 
Published: October 2022

AbstractThe late‐stage site‐selective derivatisation of peptides has many potential applications in structure‐activity relationship studies and postsynthetic modification or conjugation of bioactive compounds. The development of orthogonal methods for C−H functionalisation is crucial for such peptide derivatisation. Among them, biocatalytic methods are increasingly attracting attention. Tryptophan halogenases emerged as valuable catalysts to functionalise tryptophan (Trp), while direct enzyme‐catalysed halogenation of synthetic peptides is yet unprecedented. Here, it is reported that the Trp 6‐halogenase Thal accepts a wide range of amides and peptides containing a Trp moiety. Increasing the sequence length and reaction optimisation made bromination of pentapeptides feasible with good turnovers and a broad sequence scope, while regioselectivity turned out to be sequence dependent. Comparison of X‐ray single crystal structures of Thal in complex with d‐Trp and a dipeptide revealed a significantly altered binding mode for the peptide. The viability of this bioorthogonal approach was exemplified by halogenation of a cyclic RGD peptide.
Additional balloon aortic valvuloplasty to overcome the difficult removal of a self‐expandable transcatheter aortic valve system due to valve infolding
Authors: Yashige Masaki , Zen Kan , Takamatsu Kazuaki , Matoba Satoaki 
Published: October 2022

AbstractTranscatheter aortic valve replacement (TAVR) is a well‐established treatment for severe aortic stenosis. Advances in the devices used and operators' technique have reduced the frequency of complications. However, valve infolding is a rare but serious outcome after the implantation of self‐expanding prostheses. We report a case of a successful bailout of a device that was difficult to remove because of valve infolding. TAVR using a 26 mm Evolut PRO+ system (Medtronic) was planned for a 91‐year‐old woman with severe aortic stenosis. After the valve was deployed in a satisfactory position on the second release, the system could not be removed because the nose cone was hooked to the basal frame of the deployed valve. To overcome this situation, an additional balloon was inserted from the contralateral femoral side and inflated, and we extracted the system successfully by pulling out the device while simultaneously deflating the balloon. Postoperative computed tomography revealed valve infolding, which was considered to cause the difficulty in system removal. Infoldings of self‐expandable prostheses should be considered when faced with difficulty in removing the catheter system, and the method elucidated in this case report can be effective to manage it.
Amorphous NiCu Thin Films Sputtered on TiO2 Nanotube Arrays: A Noble‐Metal Free Photocatalyst for Hydrogen Evolution
Authors: Pinna Marco , Wei Angeline Wo Weng , Spanu Davide , Will Johannes , Yokosawa Tadahiro , Spiecker Erdmann , Recchia Sandro , Schmuki Patrik , Altomare Marco 
Published: October 2022

AbstractIn this work, NiCu co‐catalysts on TiO2 are studied for photocatalytic hydrogen evolution. NiCu co‐catalyst films are deposited at room temperature by argon plasma sputtering on high aspect‐ratio anodic TiO2 nanotubes. To tune the Ni : Cu atomic ratio, alloys of various compositions were used as sputtering targets. Such co‐catalyst films are found to be amorphous with small nanocrystalline domains. A series of parameters is investigated, i. e., i) Ni : Cu relative ratio in the sputtered films, ii) NiCu film thickness, and iii) thickness of the TiO2 nanotube layers. The highest photocatalytic activity is obtained with 8 μm long TiO2 nanotubes, sputter‐coated with a 10 nm‐thick NiCu films with a 1 : 1 Ni : Cu atomic ratio. This photocatalyst reaches a stable hydrogen evolution rate of 186 μL h−1 cm−2, 4.6 and 3 times higher than that of Ni‐ and Cu‐TiO2, respectively, demonstrating a synergistic co‐catalytic effect of Ni and Cu in the alloy co‐catalyst film.
Ligand‐Functional Groups Induced Tuning MOFs’ 2D into 1D Pore Channels for Pipeline Natural Gas Purification
Authors: Cheng Hongtao , Wang Qian , Bai Junfeng 
Published: October 2022

AbstractThe solvothermal reactions of CoCl2 ⋅ 6H2O, 3,5‐pyridinedicarboxylic acid (H2L) and isonicotinic acid (HL1)/3‐amino isonicotinic acid (HL2)/3‐chloro isonicotinic acid (HL3) successfully led to three tfz‐d topological pillar‐layer [Co4(μ‐F)2(COO)6(NC5H4)4] cluster‐based MOFs, namely, [Co4(μ‐F)2(L)2(L1)2 ⋅ 2DMA] ⋅ DMA ⋅ 2H2O (SNNU‐Bai76, SNNU‐Bai=Shaanxi Normal University Bai's group), [Co4(μ‐F)2(L)2(L2)2 ⋅ 2H2O] ⋅ 2DMA ⋅ 2H2O (SNNU‐Bai77) and [Co4(μ‐F)2(L)2(L3)2 ⋅ 2H2O] ⋅ 2DMF ⋅ 2H2O (SNNU‐Bai78). With the 2D pore channels in SNNU‐Bai76 and SNNU‐Bai77 being tuned to the 1D pore channel in SNNU‐Bai78, C3H8 and C2H6 adsorption uptakes are apparently improved and the IAST selectivities of C3H8/CH4 and C2H6/CH4 almost remain, which indicate that SNNU‐Bai78 may be one potential separation material for the pipeline natural gas purification. These were further confirmed by the breakthrough experiments for the simulated pipeline natural gas (C3H8/C2H6/CH4 : 5/10/85 gas mixture) of three isostructural MOFs. Furthermore, GCMC simulations revealed that due to one of the pore channels blocked by Cl atoms in a couple of 3‐chloro isonicotinic acid with the changed conformation as the pillar, the pore wall of the formed 1D pore channel in SNNU‐Bai78 may interact with the adsorbed C3H8 or C2H6 molecule more strongly, for which more atoms of framework at the new adsorption site will interact with the adsorbed gas molecule by more intermolecular interactions. This was also evidenced by the increased binding energies, being consistent with the tuning of adsorption enthalpies for C3H8 and C2H6 gas molecules, and the reduced C3H8 and C2H6 gas diffusion coefficients in SNNU‐Bai78. Very interestingly, this work is the first example of finely tuning the pore connectivity of MOFs toward strengthened host–guest interactions for the gas adsorption and separation.
Synthesis and Late‐Stage Diversification of BN‐Embedded Dibenzocorannulenes as Efficient Fluorescence Organic Light‐Emitting Diode Emitters
Authors: Okada Naoya , Nakatsuka Soichiro , Kawasumi Ryosuke , Gotoh Hajime , Yasuda Nobuhiro , Hatakeyama Takuji 
Published: October 2022

AbstractWe report the synthesis and late‐stage diversification of a new class of hetero‐buckybowl, BN‐embedded dibenzocorannulenes (B2N2‐DBCs). The synthesis is achieved via one‐shot halogenative borylation, comprising the nitrogen‐directed haloboration of alkyne and an intramolecular bora‐Friedel‐Crafts reaction, which provides BN‐embedded dibenzocorannulene possessing two bromo substituents (B2N2‐DBC‐Br). B2N2‐DBC‐Br undergoes diversification via coupling reactions to provide a variety of arylated derivatives (B2N2‐DBC‐R), exhibiting strong blue fluorescence. An organic light‐emitting diode (OLED) employing one of the derivatives as an emitter exhibited a high external quantum efficiency of 6.6 % and long operational lifetime of 907 h at an initial luminance of 1000 cd m−2, indicating the significant potential for the development of efficient and stable hetero‐buckybowl‐based OLED materials.
Chemical Strategies for Dendritic Magneto‐plasmonic Nanostructures Applied to Surface‐Enhanced Raman Spectroscopy
Authors: Fernandes Tiago , Nogueira Helena I. S. , Amorim Carlos O. , Amaral João S. , Daniel‐da‐Silva Ana L. , Trindade Tito 
Published: October 2022

AbstractInvited for the cover of this issue is the group of Tito Trindade and colleagues at the University of Aveiro. The image depicts dendritic magneto‐plasmonic substrates for surface‐enhanced Raman scattering (SERS) detection. Read the full text of the article at 10.1002/chem.202202382.