bluuebunny/crossref_metadata_2025_split huggingface dataset:
The dynamical motion of a rolling cylinder and its stability analysis: analytical and numerical investigation
Authors: Amer W. S. 
Published: August 2022

AbstractThe present paper addresses the dynamical motion of two degrees-of-freedom (DOF) auto-parametric system consisting of a connected rolling cylinder with a damped spring. This motion has been considered under the action of an excitation force. Lagrange's equations from second kind are utilized to obtain the governing system of motion. The uniform approximate solutions of this system are acquired up to higher order of approximation using the technique of multiple scales in view of the abolition of emerging secular terms. All resonance cases are characterized, and the primary and internal resonances are examined simultaneously to set up the corresponding modulation equations and the solvability conditions. The time histories of the amplitudes, modified phases, and the obtained solutions are graphed to illustrate the system's motion at any given time. The nonlinear stability approach of Routh–Hurwitz is used to examine the stability of the system, and the different zones of stability and instability are drawn and discussed. The characteristics of the nonlinear amplitude for the modulation equations are investigated and described, as well as their stabilities. The gained results can be considered novel and original, where the methodology was applied to a specific dynamical system.
Autologous microfragmented adipose tissue and leukocyte-poor platelet-rich plasma combined with hyaluronic acid show comparable clinical outcomes for symptomatic early knee osteoarthritis over a two-year follow-up period: a prospective randomized clinical trial
Authors: Gobbi Alberto , Dallo Ignacio , D’Ambrosi Riccardo 
Published: August 2022

Abstract
Purpose
The purpose of this prospective randomized clinical trial is to compare the clinical outcomes of three injections of leucocyte-poor platelet-rich plasma (LP-PRP) and hyaluronic acid (HA) to a single dose of autologous microfragmented adipose tissue (AMAT) in patients with mild osteoarthritis at a two-year follow-up.

Methods
Eighty symptomatic knees in fifty patients (mean age: 62.38 ± 11.88 years) with Kellgren-Lawrence grade 0 to 2 osteoarthritis were non blinded, randomly allocated into two equal groups. Group 1 consisted of 40 knees that received autologous LP-PRP + HA; Group 2 consisted of 40 knees treated with a single dose of AMAT injection. The outcomes were measured by Tegner, Marx, Visual Analogue Scale (VAS) for pain, International Knee Documentation Committee, and Knee Injury and Osteoarthritis Outcome Score (KOOS) at 6 (T1), 12 (T2), and 24 (T3) months. Adverse events were recorded at each follow-up timepoint. To assess score differences among subjects of the same gender and age, a subgroup analysis was performed.

Results
Both groups had significant clinical and functional improvement at 6, 12, and 24 months (p < 0.05). Comparing the two groups, the AMAT groups showed significantly higher pre-operative Marx score (3.35 ± 4.91 vs. 1.78 ± 3.91) and VAS score (5.03 ± 2.02 vs. 3.85 ± 1.68) (p < 0.05), higher VAS (3.89 ± 2.51 vs. 2.64 ± 2.00) at T2 and KOOS-ADL (79.60 ± 20.20 vs. 65.68 ± 23.62), and lower KOOS-Sports (50.30 ± 30.15 vs. 68.35 ± 30.39) at T3 (p < 0.05). No patient from either group had experienced major adverse effects. In the LP-PRP group 12 (30%) patients presented swelling, redness, and mild pain for one day after injection and two patients had synovitis for two days and required paracetamol and local ice. In AMAT group 5 (12.5%) patients had ecchymosis and bruising at the fat aspiration site for three days.

Conclusion
AMAT did not show significant superior clinical improvement compared with three LP-PRP combined with HA injections in terms of functional improvement at different follow-up points. Both procedures were safe with no major complications reporting good results at mid-term follow-up, improving knee function, pain, and quality of live regardless of age and gender.

Level of evidence
Level I—Prospective Randomized Clinical Trial.
How do requirements evolve during elicitation? An empirical study combining interviews and app store analysis
Authors: Ferrari Alessio , Spoletini Paola , Debnath Sourav 
Published: August 2022

AbstractRequirements are elicited from the customer and other stakeholders through an iterative process of interviews, prototyping, and other interactive sessions. Then, requirements can be further extended, based on the analysis of the features of competing products available on the market. Understanding how this process takes place can help to identify the contribution of the different elicitation phases, thereby allowing requirements analysts to better distribute their resources. In this work, we empirically study in which way requirements get transformed from initial ideas into documented needs, and then evolve based on the inspiration coming from similar products. To this end, we select 30 subjects that act as requirements analysts, and we perform interview-based elicitation sessions with a fictional customer. After the sessions, the analysts produce a first set of requirements for the system. Then, they are required to search similar products in the app stores and extend the requirements, inspired by the identified apps. The requirements documented at each step are evaluated, to assess to which extent and in which way the initial idea evolved throughout the process. Our results show that only between 30% and 38% of the requirements produced after the interviews include content that can be fully traced to initial customer’s ideas. The rest of the content is dedicated to new requirements, and up to 21% of it belongs to completely novel topics. Furthermore, up to 42% of the requirements inspired by the app stores cover additional features compared to the ones identified after the interviews. The results empirically show that requirements are not elicited in strict sense, but actually co-created through interviews, with analysts playing a crucial role in the process. In addition, we show evidence that app store-inspired elicitation can be particularly beneficial to complete the requirements.
Standardized suturing can prevent slackening or bursting suture lines in midline abdominal incisions and defects
Authors: Lesch C. , Uhr K. , Vollmer M. , Raschidi R. , Nessel R. , Kallinowski F. 
Published: August 2022

Abstract
Purpose
Incisional hernias often follow open abdominal surgery. A small-stitch–small-bite suture might close the incision durably. We analyzed specific details of this closure technique and assessed their influence on the closure stability.

Methods
The effects of cyclic loads, simulating coughs were investigated on a bench test. We prepared porcine bellies in the median line and bovine flanks parallel to the muscle fibers with 15 cm long incisions. Then we punched round or rhomboid defects with a diameter of 5–10 cm into the center of the incision. Monomax® 2–0 and Maxon® 1 and 2–0 were used as suture materials. We tested the durability of the closure with pressure impacts of 210 mmHg repeated 425 times. Throughout the experiments, we modified the suturing technique, the surgeon, the tissue tension, the defect size and shape and the suture diameter.

Results
Standardizing the suture technique improved the durability of the closure significantly. Any other variations showed minor influences after standardization. All incisions with round defects up to 7.5 cm width withstood 425 impacts using standardized suturing. Unstandardized sutures failed in all cases. When closing an incision with a 10 cm wide defect, the tissues ruptured frequently next to the suture line. We defined criteria to standardize this suturing technique. For the first time, we developed a suture factor related to the durability of a sutured tissue closure. We integrated the suture factor into the concept of biomechanically durable repairs.

Conclusions
Suturing the abdominal wall with a standardized suturing technique improves its durability significantly.
Calcification patterns of Rivularia-type cyanobacteria: examples from the Miocene of the North Alpine Foreland Basin
Authors: Willmer Bernd J. , Rasser Michael W. 
Published: August 2022

AbstractDuring the Middle Miocene, an extensive lake district existed along the southern margin of today’s Swabian Alb (Baden–Württemberg). Sediments include a wide range from marls to pure carbonates of lacustrine and palustrine origin that contain microbialites studied here. These sediments are part of the Obere Süßwassermolasse known as Silvana Beds. Macroscopically the studied microbialites show a distinctive layering with an alternation of whitish and tan-colored layers. Petrographic thin sections as well as SEM studies reveal a microstructure of the microbialites comprising an unbranched filament zone formed by erect and parallel calcified filaments as well as a zone of branching filaments forming shrubs of the Dichothrix morphotype. We define two patterns of mineralization for the studied microbialites: (1) shape-retentive mineralization: successive carbonate precipitation along the filament surface. (2) shape-obscuring mineralization: clusters of clotted micritic precipitates along and within the vicinity of micro-sparitic tubules that probably represent remains of the former cyanobacterial sheaths.
Sponge holobionts shift their prokaryotic communities and antimicrobial activity from shallow to lower mesophotic depths
Authors: Indraningrat Anak Agung Gede , Steinert Georg , Becking Leontine E. , Mueller Benjamin , de Goeij Jasper M. , Smidt Hauke , Sipkema Detmer 
Published: August 2022

AbstractIn this study, we used 16S rRNA gene amplicon sequencing to investigate prokaryotic community composition of the Caribbean spongesXestospongia mutaandAgelas sventresfrom three depth ranges: < 30 m (shallow), 30–60 m (upper mesophotic), and 60–90 m (lower mesophotic). The prokaryotic community in shallow samples ofX. mutawas enriched in Cyanobacteria, Chloroflexota, and Crenarchaeota compared to samples from mesophotic depths, while mesophotic samples ofX. mutawere enriched in Acidobacteriota. ForA. sventres, relative abundance of Acidobacteriota, Chloroflexota, and Gammaproteobacteria was higher in shallow samples, while Proteobacteria and Crenarchaeota were enriched in mesophoticA. sventressamples. Antimicrobial activity was evaluated by screening crude extracts of sponges against a set of Gram-positive and Gram-negative bacteria, a yeast, and an oomycete. Antibacterial activities from crude extracts of shallow sponge individuals were generally higher than observed from mesophotic individuals, that showed limited or no antibacterial activities. Conversely, the highest anti-oomycete activity was found from crude extracts ofX. mutaindividuals from lower mesophotic depth, but without a clear pattern across the depth gradient. These results indicate that sponge-associated prokaryotic communities and the antimicrobial activity of sponges change within species across a depth gradient from shallow to mesophotic depth.
The impact of system contraction on the rural youth access to higher education in Poland
Authors: Antonowicz Dominik , Wasielewski Krzysztof , Domalewski Jarosław 
Published: August 2022

AbstractThis papers explores the impact of the contraction of the mass HE system (after 2005) on rural youth who represent the biggest disadvantages group in Polish higher education. It provides empirical evidence that the system contraction is the major reason for widening access for rural youth to public (prestigious) higher education institutions. By doing so, it challenges a long established assumption that the HE system expansion reduced inequalities in access to higher learning. Instead, we argue that it was the contraction of HE system that widely opened university campuses to those previously underrepresented. The most prestigious public universities become more inclusive and less selective only when the traditional pool of students was exhausted and a big number of state?s funded places needed to be filled.
Distinguishing Benign and Malignant Findings on [68 Ga]-FAPI PET/CT Based on Quantitative SUV Measurements
Authors: Dabir M. , Novruzov E. , Mattes-György K. , Beu M. , Dendl K. , Antke C. , Koerber S. A. , Röhrich M. , Kratochwil C. , Debus J. , Haberkorn U. , Giesel F. L. 
Published: August 2022

Abstract

Aim/Purpose
Fibroblast activation protein (FAP) is overexpressed by cancer-associated fibroblasts. However, activated fibroblasts have been shown to play a significant role also in certain benign conditions such as wound healing or chronic inflammation. Therefore, the current study aimed to identify whether FAPI uptake might differ between malignant lesions and benign conditions.

Material and Methods
We retrospectively analyzed 155 patients with various cancer types who received [68 Ga]-FAPI-04/02-PET/CT between July 2017 and March 2020. SUVmax, SUVmean, and lesion-to-background ratios (LBR) of FAPI uptake were measured in benign processes compared to malignant lesions (primary and/or 2 exemplary metastases). In addition, receiver operating characteristic (ROC) curve analysis was conducted to compare the predictive capabilities of semiquantitative PET/CT parameters. Furthermore, the sensitivity, specificity, optimal cutoff value, and 95% confidence interval (CI) were determined for each parameter.

Results
Benign lesions exhibited significantly lower FAPI uptake compared to malignant lesions (mean SUVmax benign vs. malignant: 4.2 vs. 10.6; p < 0.001). In ROC analysis, cutoff values of these lesions (benign vs. malignant) were established based on SUVmax, SUVmean, and LBR. The SUVmax cutoff value for all lesions was 5.5 and the corresponding sensitivity, specificity, accuracy, and AUC were 78.8%, 85.1%, 82.0%, and 0.89%, respectively.

Conclusion
Our aim was to systematically analyze the pattern of FAPI uptake in benign and malignant processes. This investigation demonstrates that FAPI uptake might be useful to differentiate malignant and benign findings due to different patho-physiological origins.
Fire-induced effects on the bioavailability of potentially toxic elements in a polluted agricultural soil: implications for Cr uptake by durum wheat plants
Authors: Rascio Ida , Gattullo Concetta Eliana , Porfido Carlo , Allegretta Ignazio , Spagnuolo Matteo , Tiziani Raphael , Celletti Silvia , Cesco Stefano , Mimmo Tanja , Terzano Roberto 
Published: August 2022

Abstract
Fire events can modify the distribution and speciation of potentially toxic elements (PTEs) in soil, especially if they are associated to organic matter (OM). In fact, OM can undergo substantial structural modifications at high temperatures, up to the complete mineralization. The present study aims to investigate the changes of PTEs’ bioavailability to durum wheat (Triticum durum Desf.) plants after simulating fire events (up to 300 °C and 500 °C) in an agricultural soil polluted by Cr, Zn, Cu, and Pb. The PTEs’ uptake and allocation in plant tissues were assessed using the RHIZOtest system. After the fire simulations, no evident risk of accumulation and translocation in plants was observed for Zn, Pb, and Cu. Conversely, a high accumulation in roots and a significant translocation to shoots were observed for Cr, which reached concentrations of 829 mg kg−1 in roots and 52 mg kg−1 in shoots at 500 °C. Additional experimental evidence suggested that Cr was taken up by plants grown on heated soils as Cr(VI). Once acquired by roots, only a small part of Cr (up to 6%) was translocated to shoots where it was likely present as mobile forms, as evidenced by micro X-ray fluorescence (µ-XRF) analyses. Overall, the results obtained provide evidence that the high temperatures occurring during fire events can increase the mobility and bioavailability of certain PTEs transforming apparently safe environments into potentially dangerous sources of pollution. These processes can ultimately affect the human health through the food chain transfer of PTEs or their migration into surface water and groundwater.
Neuroimmune crosstalk and its impact on cancer therapy and research
Authors: Sharawy Iman 
Published: August 2022

AbstractCancer is a major health problem as it is the first or second leading cause of death worldwide. The global cancer burden is expected to rise 47% relative to 2020 cancer incidence. Recently, the fields of neuroscience, neuroimmunology and oncology have elaborated the neuroimmune crosstalk role in tumor initiation, invasion, progression, and metastases. The nervous system exerts a broad impact on the tumor microenvironment by interacting with a complex network of cells such as stromal, endothelial, malignant cells and immune cells. This communication modulates cancer proliferation, invasion, metastasis, induce resistance to apoptosis and promote immune evasion. This paper has two aims, the first aim is to explain neuroimmune crosstalk in cancer, tumor innervation origin and peripheral nervous system, exosomes, and miRNA roles. The second aim is to elaborate neuroimmune crosstalk impact on cancer therapy and research highlighting various potential novel strategies such as use of immune checkpoint inhibitors and anti-neurogenic drugs as single agents, drug repurposing, miRNA-based and si-RNA-based therapies, tumor denervation, cellular therapies, and oncolytic virus therapy.
Expanding Donor Heart Utilization Through Machine Perfusion Technologies
Authors: Villanueva Jeanette E. , Joshi Yashutosh , Emmanuel Sam , Gao Ling , Macdonald Peter S. 
Published: August 2022

Abstract
Purpose of Review
Recent advances in donor heart preservation have allowed the utilization of hearts that would typically be discarded due to prolonged ischemic times or donation via the circulatory death pathway. This review will discuss recent advances in donor heart preservation including optimization of machine perfusion technologies and future strategies of potential benefit for the donor heart and transplant outcomes.

Recent Findings
Improvements in organ preservation strategies have enabled retrieval of donor hearts that were not ideal for static cold storage. Machine perfusion (normothermic and hypothermic) and normothermic regional perfusion have ultimately expanded the donor pool for adult heart transplantation. Xenotransplantation has also incorporated machine perfusion for porcine donor heart preservation.

Summary
Traditional static cold storage is feasible for non-complex donors and transplants. Machine perfusion has enabled increased donor heart utilization however optimal preservation strategies are dependent on the donor criteria, predicted ischemic times and surgical complexity.
The Uses of the Outputs of the International Law Commission in International Adjudication: Subsidiary Means or Artefacts of Rules?
Authors: Lekkas Sotirios-Ioannis 
Published: August 2022

AbstractThis paper examines the methods which international courts and tribunals (ICTs) employ when using ILC outputs for the purpose of determining rules of international law and their content. Specifically, it identifies common patterns in the ways in which ICTs, first, justify their reliance on ILC outputs and, second, deal with their ambiguities. The paper argues in favour of a consistent methodology for the treatment of ILC outputs in international adjudication. Such a framework is based on the distinction between the identification of the status of a normative proposition contained in these texts and the determination of its content or its interpretation. The identification of the status of a normative proposition requires a critical assessment and reconstruction of the evidence leading up to its development taking also into account that these instruments are not a monolith from the perspective of sources. However, the interpretation of a proposition whose status is uncontested follows a line of inquiry akin to treaty interpretation. This observation has broader implications for the process of interpretation in international law. Specifically, apart from the context of treaty interpretation, international courts or tribunals interpret the normative propositions contained in ILC outputs as a methodological shortcut for the interpretation of rules of customary international law or general principles of law. Conversely, the employment of methods akin to treaty interpretation in this context can constitute evidence of the emergence of common rules, principles, or good practices of interpretation that are also applicable to unwritten international law.
Systematic review of measurement properties of the Canadian Occupational Performance Measure in geriatric rehabilitation
Authors: de Waal Margot W. M. , Haaksma Miriam L. , Doornebosch Arno J. , Meijs Rimmie , Achterberg Wilco P. 
Published: August 2022

Abstract
Purpose
The Canadian Occupational Performance Measure (COPM) is used to inventory problems experienced by the patient to set goals and evaluate treatment. We aimed to make a systematic overview of measurement properties for people in geriatric rehabilitation.

Methods
Seven electronic databases were searched for psychometric studies investigating content validity, construct validity, responsiveness, or reliability of the COPM in geriatric rehabilitation populations aged ≥ 60 years. Two reviewers independently abstracted data and assessed methodological quality from included studies.

Results
Of 292 identified articles, 13 studies were included. The COPM showed good test–retest reliability (two studies), moderate inter-rater reliability (one study), and good content validity (one study with some risk of bias). Four studies with minimal risk of bias showed good construct validity as their hypotheses were confirmed. Responsiveness was moderate in three studies with adequate methodological quality.

Conclusion
All measurement properties have been studied in geriatric rehabilitation populations, and indicate that the COPM gives relevant information for geriatric rehabilitation, and scores can be assessed reliably and are responsive to change. Although there were many studies on construct validity, authors had different opinions on what exactly COPM-scores tell us, as they used a variety of comparator instruments and different hypotheses. Consensus on exact interpretation of the scores is needed.
Challenges and Opportunities of Green Propellants and Electric Pump Feeding for Future European Kick Stages
Authors: Ordonez Valles L. , Blondel Canepari L. , Apel U. , Tajmar M. , Pasini A. 
Published: August 2022

AbstractThis paper analyses the synergy between two innovative technologies: green propellants and electric pump feeding, for a 500 N engine thrust range. The novel approach is then compared to the legacy configuration, i.e., an MMH/NTO pressure fed system. First, a discussion of the benefits and challenges of the different technologies is presented. Subsequently, the proposed configuration relying on green propellants and e-pumps is investigated. After selecting hydrogen peroxide as the baseline oxidiser, a comparative analysis of different fuel candidates is conducted, leading to the selection of propane as fuel. Furthermore, the second part of the paper weights the novel configuration against the standard one and confronts their propulsive performance and mass budget. Results show that the implementation of electric pump feeding can leverage the performance of the selected green propellant outpacing the conventional solution.