bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Effect of Lymph Node Metastases and Mesenteric Deposits in Neuroendocrine Tumors of the Small Bowel
Authors: Grillo Federica , Albertelli Manuela , Malandrino Pasqualino , Dotto Andrea , Pizza Genoveffa , Cittadini Giuseppe , Colao Annamaria , Faggiano Antongiulio 
Published: May 2022

AbstractWell-differentiated, low-grade neuroendocrine tumors (NETs) are the most frequent tumor types of the small bowel. Despite their generally indolent growth patterns and grade, these tumors tend to metastasize; indeed, at presentation, approximately 50% show nodal metastases and 30% of patients have distant metastases, even though they potentially show long survival. Little is available in the literature concerning the optimal nodal yield in small-bowel resections, and the clinical significance of nodal metastases and lymph node ratio (LNR) at this site is still debated. The aim of this review, through a systematic literature search, is to explore and analyze data regarding nodal status, adequacy of lymphadenectomy, and LNR on the prognosis of small bowel NETs using defined end points (progression-free survival, recurrence-free survival, and overall survival). Some surgical series have demonstrated that extended regional mesenteric lymphadenectomy, together with primary tumor resection, is associated with improved patient survival, and LNR is proving a prognostically important parameter. The new feature of mesenteric tumor deposits (MTDs; neoplastic deposits found in the mesenteric perivisceral adipose tissue that are not LN associated) seems to be a better prognostic predictor in small-bowel NETs compared to nodal metastases, and this feature is explored and critiqued in this review. In particular, increasing number of tumor deposits is correlated with increased risk of disease-specific death, and MTDs seem to correlate with peritoneal carcinomatosis.
Association of the SLC47A1 Gene Variant With Responses to Metformin Monotherapy in Drug-naive Patients With Type 2 Diabetes
Authors: Kim Hamin , Bae Suhyun , Yoon Ha Young , Yee Jeong , Gwak Hye Sun 
Published: May 2022

Abstract

Context
Although metformin is the first-line treatment for type 2 diabetes, the blood sugar–lowering effect of metformin varies among populations. SLC47A1 plays an important role in metformin pharmacokinetics and pharmacodynamics.

Objective
We performed a systematic review and meta-analysis to investigate the association between SLC47A1 rs2289669 (G &gt; A) and the metformin response in drug-naive patients with type 2 diabetes.

Methods
Studies published until January 27, 2022, were retrieved from Cochrane CENTRAL, Embase, PubMed, and Web of Science. Two reviewers independently screened titles, abstracts, and full-text articles. Studies conducted in newly diagnosed or drug-naive patients with type 2 diabetes who received metformin monotherapy were included. A total of 6 studies involving 953 patients were included in this meta-analysis. We extracted the study characteristics and changes in glycated hemoglobin (HbA1c) levels before and after treatment according to the SLC47A1 rs2289669 genotype. Changes in HbA1c levels were analyzed using mean differences (MDs) and 95% CIs. SLC47A1 rs2289669 was associated with changes in HbA1c levels (A carrier vs GG; MD = −0.55; 95% CI, −0.91 to − 0.20; I² = 63%). The sensitivity analysis yielded similar results to the main analysis (MD range, −0.64 to −0.37). When comparing all 3 genotypes, there were significant differences in HbA1c level changes between AA vs GG and GA vs GG, but not in GA vs AA.

Conclusion
This meta-analysis showed that SLC47A1 rs2289669 is associated with the glycemic response to metformin in drug-naive patients with type 2 diabetes.
MKLP2 functions in early mitosis to ensure proper chromosome congression
Authors: Schrock Morgan S. , Scarberry Luke , Stromberg Benjamin R. , Sears Claire , Torres Adrian E. , Tallman David , Krupinski Lucas , Chakravarti Arnab , Summers Matthew K. 
Published: May 2022

ABSTRACT
Mitotic kinesin-like protein 2 (MKLP2; also known as KIF20A) is a motor protein with a well-established function in promoting cytokinesis. However, our results with siRNAs targeting MKLP2 and small-molecule inhibitors of MKLP2 (MKLP2i) suggest that it also has a function earlier in mitosis, prior to anaphase. In this study, we provide direct evidence that MKLP2 facilitates chromosome congression in prometaphase. We employed live imaging to observe HeLa cells with fluorescently tagged histones treated with MKLP2i and discovered a pronounced chromosome congression defect. We show that MKLP2 facilitates error correction, as inhibited cells have a significant increase in unstable, syntelic kinetochore–microtubule attachments. We find that the aberrant attachments are accompanied by elevated Aurora kinase (A and B) activity and phosphorylation of the downstream target HEC1 (also known as NDC80) at Ser55. Finally, we show that MKLP2 inhibition results in aneuploidy, confirming that MKLP2 safeguards cells against chromosomal instability.
This article has an associated First Person interview with the first author of the paper.
Talking About Performance or Paying for It? A Field Experiment on Performance Reviews and Incentives
Authors: Manthei Kathrin , Sliwka Dirk , Vogelsang Timo 
Published: May 2022

We investigate the causal effect of performance pay and conversations about performance in 224 stores of a retail chain implementing a field experiment with a 2x2 factorial design. In the performance pay treatments, managers receive a bonus, which is a simple linear function of the profits achieved above a threshold value. In the performance review treatments, managers have to report their activities undertaken to increase profits in regular meetings. We find that whereas performance pay did not yield significant profit increases, performance review conversations increased profits by about 7%. However, when additionally receiving performance pay, the positive effect of performance reviews vanished. We provide evidence from surveys and meeting protocols that performance pay changes the nature of conversations, leading to a stronger self-reliance of store managers, which undermines the value of the performance reviews. This paper was accepted by Yan Chen, behavioral economics and decision analysis. Funding: Funding from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy [Grant EXC 2126/1 390838866] is gratefully acknowledged. Supplemental Material: Data and the online appendices are available at https://doi.org/10.1287/mnsc.2022.4431 .
The effectiveness of leucocyte-poor platelet-rich plasma injections on symptomatic early osteoarthritis of the knee: the PEAK randomized controlled trial
Authors: Lewis Emma , Merghani Khalid , Robertson Iain , Mulford Jonathon , Prentice Ben , Mathew Ronnie , Van Winden Peter , Ogden Kathryn 
Published: May 2022

Aims Platelet-rich plasma (PRP) intra-articular injections may provide a simple and minimally invasive treatment for early-stage knee osteoarthritis (OA). This has led to an increase in its adoption as a treatment for knee OA, although there is uncertainty about its efficacy and benefit. We hypothesized that patients with early-stage symptomatic knee OA who receive multiple PRP injections will have better clinical outcomes than those receiving single PRP or placebo injections. Methods A double-blinded, randomized placebo-controlled trial was performed with three groups receiving either placebo injections (Normal Saline), one PRP injection followed by two placebo injections, or three PRP injections. Each injection was given one week apart. Outcomes were prospectively collected prior to intervention and then at six weeks, three months, six months, and 12 months post-intervention. Primary outcome measures were Knee Injury and Osteoarthritis Outcome Score (KOOS) and EuroQol five-dimension five-level index (EQ-5D-5L). Secondary outcomes included visual analogue scale for pain and patient subjective assessment of the injections. Results A total of 102 patients were recruited. The follow-up period was 12 months, at intervals of six weeks, 12 weeks, six months, and 12 months. KOOS-Total significantly improved in all groups at these time intervals compared to pre-injection. There was an improvement in EQ-5D-5L index scores in saline and single injection groups, but not in the multiple injection group. Comparison of treatment groups showed no additional beneficial effect of single or multiple PRP injections above that displayed in the saline injection group. Subjective patient satisfaction and recommendation of treatment received demonstrated a similar pattern in all the groups. There was no indication of superiority of either single or multiple PRP injections compared to saline injections. Conclusion There is no evidence that single or multiple PRP had any additional beneficial effect compared to saline injection up to 12 months, follow-up after treatment of early stage symptomatic OA of the knee. Cite this article: Bone Joint J 2022;104-B(6):663–671.
Surgical fixation of rib fractures improves 30-day survival after significant chest injury
Authors: Craxford Simon , Marson Ben A. , Nightingale Jessica , Forward Daren P. , Taylor Andrew , Ollivere Ben 
Published: May 2022

Aims The last decade has seen a marked increase in surgical rib fracture fixation (SRF). The evidence to support this comes largely from retrospective cohorts, and adjusting for the effect of other injuries sustained at the same time is challenging. This study aims to assess the impact of SRF after blunt chest trauma using national prospective registry data, while controlling for other comorbidities and injuries. Methods A ten-year extract from the Trauma Audit and Research Network formed the study sample. Patients who underwent SRF were compared with those who received supportive care alone. The analysis was performed first for the entire eligible cohort, and then for patients with a serious (thoracic Abbreviated Injury Scale (AIS) ≥ 3) or minor (thoracic AIS < 3) chest injury without significant polytrauma. Multivariable logistic regression was performed to identify predictors of mortality. Kaplan-Meier estimators and multivariable Cox regression were performed to adjust for the effects of concomitant injuries and other comorbidities. Outcomes assessed were 30-day mortality, length of stay (LoS), and need for tracheostomy. Results A total of 86,838 cases were analyzed. The rate of SRF was 1.2%. SRF significantly reduced risk of mortality (odds ratio (OR) 0.27 (95 confidence interval (CI) 0.128 to 0.273); p < 0.001) and need for tracheostomy (OR 0.22 (95% CI 0.191 to 0.319); p < 0.001) after adjustment for other covariables across the whole cohort. SRF remained protective in patients with a serious chest injury (hazard ratio (HR) 0.24 (95% CI 0.13 to 0.45); p < 0.001). The benefit in more minor chest injury was less clear. Mean LoS for patients who survived was longer in the SRF group (24.29 days (SD 26.54) vs 16.60 days (SD 26.35); p < 0.001). Conclusion SRF reduces mortality after significant chest trauma associated with both major and minor polytrauma. The rate of fixation in the UK is low and potentially underused as a treatment for severe chest wall injury. Cite this article: Bone Joint J 2022;104-B(6):729–735.
Comparing Perspectives Between Different Agency Structures and Support Models
Authors: Johnson Katherine E. , Bailey Caitlin E. , Weiss Nancy R. , Eidelman Steven M. 
Published: May 2022

Abstract
The roles and responsibilities of direct support professionals (DSPs) are evolving. This qualitative study explores how DSPs perceive their role and explores those perceptions across DSPs working in traditional, intermediate, and innovative agencies, as defined for the study. Examining 440 DSP survey responses and interviews with 24 DSPs, we found that DSPs working in more individualized settings tended to have expanded role functions (focused on promoting self-determination and community engagement). DSPs working in more traditional settings tended to have more care-focused role functions (concentrated on activities of daily living, medication administration, and health and safety). The role perception of DSPs at intermediate agencies and role conflict due to competing responsibilities demonstrate a need to systemically transform future service delivery.
Citicoline in acute ischemic stroke: A randomized controlled trial
Authors: Agarwal Ayush , Vishnu Venugopalan Y. , Sharma Jyoti , Bhatia Rohit , Garg Ajay , Dwivedi Sadanand , Upadhyay Ashish , Goyal Vinay , Singh Mamta Bhushan , Gupta Anu , Rajan Roopa , Srivastava M. V. Padma 
Published: May 2022

IntroductionTwo pharmacological possibilities exist for an acute ischemic stroke (AIS): recanalization of the occluded artery and neuroprotection from ischaemic injury, the latter’s efficacy being debatable. We sought to determine whether administration of Citicoline immediately after recanalization therapy for AIS would improve clinical and radiological outcome at three months compared to standard treatment alone.Patients and methodsCAISR was a single centre, randomized, placebo-controlled, parallel-group trial with blinded endpoint assessment. It was approved by the All India Institute of Medical Sciences Institutional ethics committee and registered at the Clinical Trial Registry of India (CTRI/2018/011900). We recruited participants with AIS undergoing recanalization therapy and randomly assigned them to receive either Citicoline or placebo in 1:1 ratio. Citicoline arm patients received Citicoline 1gm BD intravenously for three days, followed by oral citicoline 1gm BD for 39 days. Placebo arm patients received 100ml intravenous normal saline for three days, followed by multivitamin tablet BD for 39 days. All patients received standard of care.OutcomeBlinded assessors did the follow-up assessment at six weeks (MRI Brain-stroke volume) and three months (NIHSS 0–2, mRS 0–2 and Barthel index> = 95).ResultsThe infarct volume decreased from week 1 to week 6 by 2.6 cm3on placebo versus 4.2 cm3on Citicoline (p-0.483). The OR for achieving NIHSS 0–2, mRS 0–2 and Barthel index> = 95 with Citicoline was found to be 0.96(95%CI 0.39–2.40), 0.92(95%CI 0.40–2.05) and 0.87(95%CI 0.22–2.98) respectively.ConclusionCAISR was the first to evaluate the role of Citicoline, when used immediately after recanalization therapy, when the penumbral tissue is the most susceptible either to be protected from injury or become ischemic. We did not find any significant difference between the Citicoline or placebo arms with respect to either our primary or secondary outcomes.
Diagnóstico de Políticas de Gênero no Sertão Pernambucano / Diagnosis of Gender Policies in the Outback of Pernambuco
Authors: Pereira Fernanda Gomes de Sá , Sobral Eryka Fernanda Miranda , Melo Fagner Jose Coutinho de 
Published: May 2022

Resumo: Este trabalho objetivou conhecer o funcionamento das políticas públicas para mulheres no sertão do estado de Pernambuco. Inicialmente tratou-se as definições das políticas públicas para mulher e de gênero. Num segundo momento a partir da aplicação de um questionário semiestruturado analisou-se o perfil socioeconômico das mulheres e o uso de políticas na cidade de Salgueiro-PE. Os resultados obtidos revelaram que a maioria das mulheres precisam de políticas públicas alguma vez na vida, mostra que a existência de política de gênero ainda é muito falha na região, já que perguntadas sobre a existência de algum programa no município de análise que especialize mulheres em trabalhos que são ditos para homens, cerca de 90% respondeu não saber. Além disso, mesmo em meio a tanta discussão sobre o tema, os dados sugerem que ainda há muito preconceito em relação ao gênero feminino. Abstract: This work aimed to know the functioning of public policies for women in the outback of the state of Pernambuco. Initially, the definitions of public policies for women and gender were dealt with. In a second step, from the application of a semi-structured questionnaire, the socioeconomic profile of women and the use of policies in the city of Salgueiro-PE were analyzed. The results obtained revealed that the majority of women need public policies at some time in their lives, it shows that the existence of gender policy is still very flawed in the region, as they are asked about the existence of any program in the municipality of analysis that specializes women in jobs that are said for men, about 90% said they did not know. In addition, even in the midst of so much discussion on the topic, the data suggest that there is still a lot of prejudice against the female gender.Keywords: Gender Inequality; Woman; Public Policy; Gender Policy; Pernambucano Outback.
Identificação da Cultura Organizacional: Um Estudo em uma Empresa de Campestre - Maranhão / Identification of Organizational Culture: A Study in a Countryside Company - Maranhão
Authors: Oliveira Júnior José Célio Nascimento de , Andrade Jailza Do Nascimento Tomaz 
Published: May 2022

Resumo: A cultura organizacional é importante para que as empresas possam atingir o melhor engajamento entre os colaboradores e gestores, em busca de melhores resultados para a corporação. Surge o questionamento acerca de como identificar qual o modelo de cultura que é predominante em uma empresa de Campestre – Maranhão, na busca de compreender em qual deles os colaboradores mais identificariam as características dos modelos de cultura. Como método foi utilizado um questionário baseado no modelo de pesquisa OCAI (Organizational Culture Assessment Instrument), que serve para identificar qual o modelo predominante na empresa. Através do questionário aplicado e analisado, foi possível determinar que a cultura Hierárquica foi a que atingiu as maiores pontuações, ou seja, é a que predomina na empresa. Além de investigar qual a cultura organizacional ganha destaque em uma empresa, é importante fomentar mais pesquisas correlacionadas ao tema, para melhorar os ambientes empresariais.Palavras-chave: Cultura Organizacional. OCAI. Campestre. Cultura. Abstract: Organizational culture is important for companies to achieve better engagement between employees and managers, in search of better results for the corporation. The question arises in order to identify which culture model is predominant in a company from Campestre - Maranhão, in the search to understand in which of them the employees most identify the characteristics of the culture models. As a method, a questionnaire based on the OCAI (Organizational Culture Assessment Instrument) research model was used, which serves to identify the predominant model in the company. Through the questionnaire applied and analyzed, it was possible to determine that the Hierarchical culture was the one that reached the highest scores, that is, it is the one that predominates in the company. In addition to investigating which organizational culture is highlighted in a company, it is important to encourage more research related to the topic, to improve business environments.Keywords: Organizational culture. OCAI. country. Culture.
Neuroprotective Properties of Omega-3 in Ischemic Cerebrovascular Accident: A Systematic Review / Propriedades Neuroprotetoras do Ômega-3 no Acidente Vascular Cerebral Isquêmico: Uma Revisão Sistemática
Authors: Feitosa Pedro Walisson Gomes , Moreira Jorge Lucas De Sousa , Macedo Lorena Magalhães de , Medeiros João Heitor Basílio de , Teles Rian Brito , Correia Alyne Oliveira , Ribeiro Caroline De Almeida Cabral , Nobre Maria Elizabeth Pereira 
Published: May 2022

Abstract: Cerebrovascular Accident (CVA) is a neurological disorder whose pathophysiology of ischemic side occurs together with the development of a central inflammatory process. Thus, omega-3 fatty acids appear as a potential agent in the prevention and treatment of the repercussions of this ischemic event. This work aims to develop a systematic review of the literature on the neuroprotective potential of omega-3 in terms of preventive and therapeutic aspects in ischemic stroke. A bibliographic review was carried out in the PubMed and Scopus electronic databases, and 12 indexed articles were included in the final sample and applied for discussion. Studies have pointed to the decrease in omega-3 as harmful to nerve tissue regeneration, as well as the neuroprotective role of omega-3 in cerebral ischemia after ischemia-reperfusion injury in animal models. Reduction of cerebral edema, promotion of angiogenesis, preservation of the integrity of the blood-brain barrier and tissue protection were also observed.Keywords : Cerebral ischemia. Omega-3 Polyunsaturated Fatty Acids. Neuroprotection. Resumo: O Acidente Vascular Encefálico (AVE) é um distúrbio neurológico cuja fisiopatologia do lado isquêmico ocorre juntamente com o desenvolvimento de um processo inflamatório central. Dessa forma, os ácidos graxos ômega-3 aparecem como potencial agente na prevenção e tratamento das repercussões desse evento isquêmico. Este trabalho tem como objetivo desenvolver uma revisão sistemática da literatura sobre o potencial neuroprotetor do ômega-3 quanto aos aspectos preventivos e terapêuticos no AVC isquêmico. Foi realizada uma revisão bibliográfica nas bases de dados eletrônicas PubMed e Scopus sendo que 12 artigos indexados foram incluídos na amostra final e aplicados para discussão. Os estudos apontaram a diminuição do ômega-3 como prejudicial à regeneração dos tecidos nervosos, bem como o papel neuroprotetor do ômega-3 na isquemia cerebral após lesão de isquemia-reperfusão em modelos animais. Também foram observadas redução do edema cerebral, promoção da angiogênese, preservação da integridade da barreira hematoencefálica e proteção tecidual.Palavras-chave: Isquemia cerebral. Ácidos graxos poliinsaturados ômega-3. Neuroproteção.