bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Pharmacotherapy for Depression after Adult Traumatic Brain Injury: an Umbrella Review
Authors: Hicks Amelia J. , Clay Fiona J. , James Amelia C. , Hopwood Malcolm , Ponsford Jennie L. 
Published: June 2022

AbstractSymptoms of depression are common following traumatic brain injury (TBI), impacting survivors’ ability to return to work, participate in leisure activities, and placing strain on relationships. Depression symptoms post TBI are often managed with pharmacotherapy, however, there is little research evidence to guide clinical practice. There have been a number of recent systematic reviews examining pharmacotherapy for post TBI depression. The aim of this umbrella review was to synthesize systematic reviews and meta-analyses of the effectiveness of pharmacotherapy for the management of post TBI depression in adults. Eligible reviews examined any pharmacotherapy against any comparators, for the treatment of depression in adults who had sustained TBI. Seven databases were searched, with additional searching of online journals, Research Gate, Google Scholar and the TRIP Medical Database to identify published and unpublished systematic reviews and meta-analyses in English up to May 2020. A systematic review of primary studies available between March 2018 and May 2020 was also conducted. Evidence quality was assessed using Joanna Briggs Institute Critical Appraisal Instruments. The results are presented as a narrative synthesis. Twenty-two systematic reviews were identified, of which ten reviews contained a meta-analysis. No new primary studies were identified in the systematic review. There was insufficient high quality and methodologically rigorous evidence to recommend prescribing any specific drug or drug class for post TBI depression. The findings do show, however, that depression post TBI is responsive to pharmacotherapy in at least some individuals. Recommendations for primary studies, systematic reviews and advice for prescribers is provided. Review Registration PROSPERO (CRD42020184915).
Pilot Study: PARP1 Imaging in Advanced Prostate Cancer
Authors: Dehdashti Farrokh , Reimers Melissa A. , Shoghi Kooresh I. , Chen Delphine L. , Luo Jingqin , Rogers Buck , Pachynski Russell K. , Sreekumar Sreeja , Weimholt Cody , Zhou Dong 
Published: June 2022

Abstract

Purpose
PARP inhibitor (PARPi) therapy is approved for patients with metastatic castration-resistant prostate cancer (mCRPC) and homologous recombination repair (HRR) genomic aberrations. However, only a fraction of patients with BRCA1/2 mutations respond to PARPi therapy. In this pilot study, we assess PARP-1 expression in prostate cancer patients with and without HRR genomic alternations using a novel PARP-based imaging agent.

Procedures
Nine advanced prostate cancer patients were studied with PET/CT and [18F]FluorThanatrace (FTT), an analogue of the PARPi rucaparib. Images were analyzed using maximum standardized uptake values (SUVmax). PARP expression was assessed by immunohistochemistry (IHC) when feasible (n = 4).

Results
We found great variability in FTT uptake (SUVmax range: 2.3–15.4). Patients with HRR mutations had a significantly higher SUVmax (p = 0.0379) than patients with non-HRR mutations although there was an overlap in FTT uptake between groups. Three patients without HRR and one with HRR mutations had similarly high PARP1 IHC expression.

Conclusions
FTT-PET/CT may serve as an alternate biomarker for PARP1 expression and a potential method for PARPi treatment selection.
Rethinking climate migration in sub-Saharan Africa from the perspective of tripartite drivers of climate change
Authors: Ibrahim Bachar , Mensah Henry 
Published: June 2022

AbstractThere is limited attention on climate change (CC) and human migration among scholars and policymakers. Meanwhile, natural disasters are projected to induce migration in the coming years which will affect millions of people in sub-Saharan Africa (SSA). In this review, we contribute to climate migration literature by highlighting three important factors (i.e. floods, droughts, and sea-level rise) that predispose migrants in SSA to migrate. The review suggests that the environmental impact of CC in SSA cannot be overlooked. For example, the review discovered that the impact of flooding has intensified, and its impact on agriculture will affect rural–urban migration, forcing farmers to look for alternative job opportunities. Moreover, due to the lack of rainfall to support agricultural activities, the option of migrating away from agriculture and settling in urban areas becomes a possible coping strategy. Rising sea level will adversely affect many, due to a lack of adaptive capacity and emergency preparedness. This should concern policymakers because the major trend in migration, whether climate-related or not, is a movement from rural to urban areas which poses significant challenges to urban sustainability and climate resilience. Given the impact of floods, droughts, and sea-level rise in SSA, we propose the promotion of adaptive capacity through the encouragement of climate insurance programme which is limited in SSA, alternative livelihood opportunity programmes, and providing financial resources for climate adaptation initiatives.
Extended reduced-form framework for non-life insurance
Authors: Biagini Francesca , Zhang Yinglin 
Published: June 2022

AbstractIn this paper we propose a general framework for modeling an insurance liability cash flow in continuous time, by generalizing the reduced-form framework for credit risk and life insurance. In particular, we assume a nontrivial dependence structure between the reference filtration and the insurance internal filtration. We apply these results for pricing and hedging non-life insurance liabilities in hybrid financial and insurance markets, while taking into account the role of inflation under the benchmarked risk-minimization approach. This framework offers at the same time a general and flexible structure, and an explicit and treatable pricing-hedging formula.
Business portfolio reconfiguration and firm performance: The contingency role of organizational capabilities, slack and ownership
Authors: Chen Kuo-Liang , Chen Chung-Jen , Hsieh Jia-Shiuan , Lin Ya-Hui 
Published: June 2022

AbstractThe purpose of this study aims to explore the relationships between business portfolio reconfiguration and firm performance in developing countries as well as the moderating roles played by organizational slack, capabilities and ownership structure. By using the perspectives of dynamic capabilities, resources-based view and social network, this study proposes that there is aU-shaped relationship between business portfolio reconfiguration and firm performance. Furthermore, while R&D capability, marketing capability and foreign ownership are expected to positively moderate thisU-shaped relationship, organizational slack, state and domestic ownership may potentially make thisU-shaped relationship less pronounced. We draw our observations from Shanghai and Shenzhen Stock Exchanges in China from 2008 to 2017, and obtain 26,151 firm-year observations, which are consisted of 3,508 publicly traded companies. The results generally support our hypotheses, and some theoretical and practical implications are extracted from this study.
Why Join the Fed?
Authors: Calomiris Charles W. , Jaremski Matthew 
Published: June 2022

We study the decisions of state-chartered banks to join the Fed in its first decade. Ours is the first study to combine state regulatory environment characteristics and individual bank characteristics to explain Fed membership choice. Regulatory environments that reduced the benefit of discount window access or increased the regulatory cost of joining the Fed led to fewer banks joining. Individual bank characteristics that affected the magnitude of benefits from accessing the discount window (either passing on liquidity risk reduction to respondents or reducing the member bank’s own seasonal liquidity risk) were even more important in determining which banks joined.I believe that, through the Federal Reserve Banks, … the better shall we be equipped to cope with the problems ahead of us, of helping ourselves and of helping the world; I believe it to be the duty of every bank in the country to contribute its share in equipping our nation for this task; … I firmly believe that the future will belong to those banks—national or state—that are members of the Federal Reserve System.—Paul Warburg, Speech at the New York State Bankers’ Association Convention, 9 June 1916
Current status of Clonorchis sinensis and clonorchiasis in Korea: epidemiological perspectives integrating the data from human and intermediate hosts
Authors: Yoo Won Gi , Sohn Woon-Mok , Na Byoung-Kuk 
Published: June 2022

AbstractClonorchis sinensis is a carcinogenic liver fluke that causes clonorchiasis in humans. Clonorchiasis is prevalent in East Asian countries, and approximately 15–20 million individuals are estimated to be infected with this fluke globally. This review highlights the current status of C. sinensis and clonorchiasis in Korea from the epidemiological perspective involving the analysis of humans and intermediate hosts. Despite the recent decline in C. sinensis infection rate in Korea, C. sinensis infections remain endemic in 5 major river basins (Han-gang, Geum-gang, Seomjin-gang, Yeongsan-gang and Nakdong-gang; gang means river) with a high incidence of cholangiocarcinoma. A noticeable pattern involves increasing mild infections among patients diagnosed positive for C. sinensis eggs. The infection rate of C. sinensis metacercariae in the second intermediate host, freshwater fish, is also maintained at a substantial level. Thus, the One Health approach integrating different sectors and disciplines is recommended to accelerate and sustain control of C. sinensis, thereby leading to successful eradication. Health promotion via information dissemination and health education should be extended to prevent the consumption of raw freshwater fish by residents living in high-risk areas.
Enlarged Field of View in Spatially Modulated Selective Volume Illumination Microscopy
Authors: Calisesi Gianmaria , Ancora Daniele , Tacconi Carlotta , Fantin Alessandro , Perin Paola , Pizzala Roberto , Valentini Gianluca , Farina Andrea , Bassi Andrea 
Published: June 2022

Abstract
Three-dimensional fluorescence microscopy is a key technology for inspecting biological samples, ranging from single cells to entire organisms. We recently proposed a novel approach called spatially modulated Selective Volume Illumination Microscopy (smSVIM) to suppress illumination artifacts and to reduce the required number of measurements using an LED source. Here, we discuss a new strategy based on smSVIM for imaging large transparent specimens or voluminous chemically cleared tissues. The strategy permits steady mounting of the sample, achieving uniform resolution over a large field of view thanks to the synchronized motion of the illumination lens and the camera rolling shutter. Aided by a tailored deconvolution method for image reconstruction, we demonstrate significant improvement of the resolution at different magnification using samples of varying sizes and spatial features.
Sources of the Levantine Intermediate Water in Winter 2019
Authors: Taillandier V. , D’Ortenzio F. , Prieur L. , Conan P. , Coppola L. , Cornec M. , Dumas F. , Durrieu de Madron X. , Fach B. , Fourrier M. , Gentil M. , Hayes D. , Husrevoglu S. , Legoff H. , Le Ster L. , Örek H. , Ozer T. , Poulain P. M. , Pujo‐Pay M. , Ribera d’Alcalà M. , Salihoglu B. , Testor P. , Velaoras D. , Wagener T. , Wimart‐Rousseau C. 
Published: June 2022

AbstractClimatic changes and interannual variability in the Mediterranean overturning circulation are crucially linked to dense water formation in the Levantine Sea, namely the Levantine Intermediate Water whose formation zone, comprising multiple and intermittent sources, extends over fluctuating pathways. To probe into the variability of this water formation and spreading, a unique dataset was collected during the winter of 2019 in the western Levantine Sea, via oceanographic cruises, profiling floats and a glider, at a spatio‐temporal distribution suited to resolve mesoscale circulation features and intermittent convection events. This study highlights the competition between two source regions, the Cretan Sea and the Rhodes Cyclonic Gyre, to supply the Mediterranean overturning circulation in Levantine Intermediate Water. The Cretan source was estimated as the most abundant, supported by increasingly saltier water masses coming from the Levantine Sea under the pumping effect of a water deficit caused by strong western outflow toward the Ionian Sea.
Fluid‐Driven Transport of Round Sediment Particles: From Discrete Simulations to Continuum Modeling
Authors: Zhang Qiong , Deal Eric , Perron J. Taylor , Venditti Jeremy G. , Benavides Santiago J. , Rushlow Matthew , Kamrin Ken 
Published: June 2022

AbstractBedload sediment transport is ubiquitous in shaping natural and engineered landscapes, but the variability in the relation between sediment flux and driving factors is not well understood. At a given Shields number, the observed dimensionless transport rate can vary over a range in controlled systems and up to several orders of magnitude in natural streams. Here, we (a) experimentally validate a resolved fluid‐grain numerical scheme (Lattice Boltzmann Method‐Discrete Element Method or DEM‐LBM), and use it to (b) explore the parameter space controlling sediment transport in simple systems. Wide wall‐free simulations show the dimensionless transport rate is not influenced by the slope, fluid depth, mean particle size, particle surface friction, or grain‐grain damping for gentle slopes (0.01–0.03) at a medium to high fixed Shields number. (c) Examination of small‐scale fluid‐grain interactions shows fluid torque is non‐negligible for the entrainment and sediment transport near the threshold. And (d) the simulations guide the formulation of continuum models for the transport process. We present an upscaled two‐phase continuum model for grains in a turbulent fluid and validate it against bedload transport DEM‐LBM simulations. To model the creeping granular flow under the bed surface, we use an extension of the Nonlocal Granular Fluidity model, which was previously shown to account for flow cooperativity from grain‐size‐effects in dry media. The model accurately predicts the exponentially decaying velocity profile deeper into the bed.
Beinvenenthrombose und Lungenembolie nach Varizensklerosierung
Authors: Elsner Peter , Meyer Jochen 
Published: June 2022

ZUSAMMENFASSUNGBei einer Patientin erfolgte unter der klinischen Diagnose „Venektasien Oberschenkel- und Unterschenkelbereich“ eine Schaumsklerosierungsbehandlung mittels Äthoxysklerolschaum. 5 Tage später stellte sich die Patientin mit starken Schmerzen im Wadenbereich und starker Behinderung beim Auftreten wieder vor, wobei nach klinischer Befunderhebung mit diskretem Rötungsnachweis der Verdacht auf eine Thrombophlebitis geäußert wurde. Die Behandlung erfolgte mit Ibuprofen. Ein Termin zu einer duplexsonografischen Untersuchung 11 Tage später wurde vereinbart, von der Patientin allerdings erst nach 16 Tagen wahrgenommen, wobei eine Phlebografie erfolgte, die eine tiefe Venenthrombose zeigte. Eine folgende stationäre Behandlung ergab zusätzlich eine Lungenarterienembolie.Die Patientin bemängelte ihre Behandlung in der Hautarztpraxis. Durch eine fehlerhafte Verödungsbehandlung bzw. Nachkontrolle sei eine tiefe Thrombose mit nachfolgender Lungenembolie nicht erkannt worden und durch Verkennung offenkundiger Symptome eine Falschbehandlung erfolgt.Von einem hinzugezogenen dermatologischen Gutachter und der Schlichtungsstelle wurde ein Behandlungsfehler bestätigt. Die Verödungstherapie stellte zwar eine anerkannte Behandlungsmethode der Varikosis nach Facharztstandard dar. Eine tiefe Venenthrombose nach Sklerosierungstherapie ist zwar sehr selten, jedoch wären nach Wiedervorstellung der Patientin wegen erheblicher Beschwerden weiterführende diagnostische Maßnahmen, insbesondere eine duplexsonografische Abklärung, ohne wesentliche Zeitverzögerung indiziert gewesen. Es handelte sich um einen Befunderhebungsmangel, der im konkreten Fall zu einer Beweislastumkehr hinsichtlich der Kausalität des Behandlungsfehlers für den eingetretenen Schaden führte.Nach endovenösen Eingriffen bei Varikosis sind tiefe Venenthrombosen mit dem Risiko einer Lungenembolie seltene, aber typische Komplikationen. Bei nach einer Schaumsklerosierung auftretenden Extremitätenschmerzen sollte eine tiefe Venenthrombose differenzialdiagnostisch erwogen und unverzüglich durch eine Duplexsonografie und Bestimmung der D-Dimere bestätigt oder ausgeschlossen und ggf. leitliniengerecht therapiert werden. Die Verzögerung eines indizierten Thromboseausschlusses kann als schuldhafter Befunderhebungsfehler mit der Folge der Beweislastumkehr gewertet werden.
Interventionelle Behandlungsoptionen bei vaskulären Malformationen
Authors: Müller-Wille René , Wildgruber Moritz , Wohlgemuth Walter A. 
Published: June 2022

Zusammenfassung
Klassifikation von vaskulären Malformationen Während Hämangiome zu den vaskulären Tumoren zählen, sind vaskuläre Malformationen angeboren und bilden sich von selbst nicht zurück. Sie werden nach der ISSVA-Klassifikation unterschieden.
Indikation zur Therapie Ziele der Therapie von Gefäßmalformationen sind die Linderung der Symptome, der Organerhalt und die Verhinderung von Krankheitsprogress und Komplikationen.
Nichtinvasive Therapieoptionen Die Kompressionstherapie sowie physiotherapeutische Maßnahmen zählen zu den wichtigsten konservativen Therapieoptionen.
Invasive Therapieoptionen Die chirurgische Resektion, die oberflächliche Lasertherapie und die interventionelle Therapie stellen die invasiven Therapieoptionen dar. Für die Behandlung symptomatischer Gefäßmalformationen stehen mittlerweile zahlreiche minimalinvasive interventionelle Verfahren zur Verfügung. Slow-Flow-Malformationen können relativ komplikationsarm mittels perkutaner Sklerotherapie behandelt werden, die zu einem zeitversetzten entzündlichen Verschluss der Läsion führt. Dysplastische Venen wie die Marginalvene können mittels endoluminaler Verfahren erfolgreich verödet werden. Die zumeist Katheter-gesteuerten Embolisationsverfahren mittels Flüssigembolisaten, Plugs und Coils erlauben den Verschluss von Fast-Flow-Gefäßmalformationen.
Männer- und Frauenhaut – Genderaspekte
Authors: Bayerl Christiane 
Published: June 2022

ZusammenfassungMänner- und Frauenhaut sind unterschiedlich. Männerhaut ist dicker, hat mehr Talgdrüsen und Oberflächenlipide, eine höhere, nicht so divergente Keimzahl wie Frauen, niedrigere transepidermale Wasserverlust (TEWL)-Werte und einen niedrigeren pH-Wert. Die Wundheilung und das Niveau von Antioxidantien ist bei Frauenhaut besser. Männerhaut hat mehr Kollagen, altert an anderer Lokalisation, bei Männern finden sich mehr Falten an der Stirn, bei Frauen mehr Falten perioral. Studien sollten die Auswertung der Daten nach Geschlechtern mit beachten.
Air flow over a flapping bird’s wing at low Reynolds numbers: discussions in a teaching demonstration
Authors: Williams Hollis 
Published: June 2022

Abstract
Bird wings are frequently modelled in the aerodynamics literature under the assumption that they are static aerofoils. Air flows over real bird wings can violate this assumption, both because of the topology of the wing and the fact that real wings typically undergo flapping and twisting motions during flight. There are many computational and numerical studies of air flows on flapping bird’s wings at low Reynolds numbers, but relatively few experimental studies due to the difficulty of modelling a realistic flapping motion. In this article, the flow on a real flapping bird wing is visualised in a teaching demonstration using high-speed photography. It is found that the main features of the flow can be observed and that the demonstration is a teaching aid for assisting student understanding of principles of aerodynamics. The possibility of incorporating the demonstration into a standard teaching course is discussed, with relevant teaching objectives highlighted. In conclusion, it is recommended that the demonstration could be useful as part of a course on aerodynamics, with further follow-up demonstrations and studies suggested.
Membrane-boundd-mannose isomerase of acetic acid bacteria: finding, characterization, and application
Authors: Adachi Osao , Kataoka Naoya , Matsushita Kazunobu , Akakabe Yoshihiko , Harada Toshihiro , Yakushi Toshiharu 
Published: June 2022

ABSTRACTd-Mannose isomerase (EC 5.3.1.7) catalyzing reversible conversion between d-mannose and d-fructose was found in acetic acid bacteria. Cell fractionation confirmed the enzyme to be a typical membrane-bound enzyme, while all sugar isomerases so far reported are cytoplasmic. The optimal enzyme activity was found at pH 5.5, which was clear contrast to the cytoplasmic enzymes having alkaline optimal pH. The enzyme was heat stable, and the optimal reaction temperature was observed at around 40-60 °C. Purified enzyme after solubilization from membrane fraction showed the total molecular mass of 196 kDa composing of identical 4 subunits of 48 kDa. Washed cells or immobilized cells were well functional at nearly 80% of conversion ratio from d-mannose to d-fructose and reversely 20%-25% of d-fructose to d-mannose. Catalytic properties of the enzyme were discussed with respect to the biotechnological applications to high fructose syrup production from konjac taro.
A simple and general debiased machine learning theorem with finite-sample guarantees
Authors: Chernozhukov V , Newey W K , Singh R 
Published: June 2022

Summary
Debiased machine learning is a meta-algorithm based on bias correction and sample splitting to calculate confidence intervals for functionals, i.e., scalar summaries, of machine learning algorithms. For example, an analyst may seek the confidence interval for a treatment effect estimated with a neural network. We present a non-asymptotic debiased machine learning theorem that encompasses any global or local functional of any machine learning algorithm that satisfies a few simple, interpretable conditions. Formally, we prove consistency, Gaussian approximation and semiparametric efficiency by finite-sample arguments. The rate of convergence is $n^{-1/2}$ for global functionals, and it degrades gracefully for local functionals. Our results culminate in a simple set of conditions that an analyst can use to translate modern learning theory rates into traditional statistical inference. The conditions reveal a general double robustness property for ill-posed inverse problems.
Serum Levels of Infliximab Biosimilar in a Child Delivered From a Mother Treated for Ulcerative Colitis
Authors: Kawamoto Ami , Fujii Toshimitsu , Mitani Ryuji , Suzuki Yasuhiro , Yauchi Tsunehito , Okamoto Ryuichi 
Published: June 2022

Lay Summary
The infliximab biosimilar CT-P13 is used for the treatment of ulcerative colitis. We report for the first time the serum drug levels and long-term health status of the child of a patient treated with CT-P13 throughout her pregnancy.
Combined mitral valve replacement and coronary artery bypass grafting through a left thoracotomy after retrosternal oesophageal reconstruction
Authors: Numaguchi Ryosuke , Shiiku Chikara 
Published: June 2022

Abstract
A 74-year-old man with a history of retrosternal oesophageal reconstruction was referred for surgical treatment of mitral valve regurgitation and coronary artery disease. He underwent mitral valve replacement combined with coronary artery bypass grafting through a left thoracotomy. Combined mitral valve replacement and coronary artery bypass grafting through a left thoracotomy were feasible in this patient with a retrosternal neo-oesophageal conduit.