bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of urinary polycyclic aromatic hydrocarbon metabolites with symptoms among autistic children: A case–control study in Tianjin, China
Authors: Li Peiying , Yang Qiaoyun , Li Yao , Han Yu , Qu Zhiyi , Gao Lei , Cui Tingkai , Xiong Wenjuan , Xi Wei , Zhang Xin 
Published: August 2022

AbstractPolycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants that are associated with altered neurodevelopment and various neurodevelopmental disorders. However, studies evaluating internal biomarkers of PAH exposure in reference to the severity of autism spectrum disorder (ASD) symptomology and autistic behaviors are scarce. Hence, we conducted a case–control study evaluating 12 urinary hydroxylated PAH metabolites (i.e., hydroxy‐PAHs) in 101 children with autism and 101 neurotypical children, matching according to sex and age in a 1:1 ratio. In children with ASD, the severity of symptomology and autistic behaviors were assessed using the child autism rating scale (CARS) and the autism behavior checklist (ABC). We found that urinary levels of nine of the hydroxy‐PAHs were statistically significantly higher in the ASD group, with the exception of 2‐hydroxynaphthalene (2‐OHNap) and 4‐hydroxyphenanthrene (4‐OHPhe). Moreover, urinary hydroxy‐PAH levels were associated with ASD risk, with odds ratios ranging from 1.86 to 17.19. Exposures to 1‐hydroxynaphthalene (1‐OHNap, β = 3.32), hydroxyphenanthrenes (1/2/3 + 9‐OHPhes, β = 3.41–5.12), 1‐hydroxypyrene (1‐OH‐Pyr; β = 3.91), 2‐hydroxybenzofuran (2‐OHDBF; β = 3.93), and ∑OH‐PAHs (β = 4.67) were positively associated with CARS scores after adjusting for covariates (all p < 0.05). When applying the ABC scale, 1‐OHPyr levels were positively associated with ABC total scores (β = 18.54), with the strongest associations evidenced in regard to the social relatedness (β = 6.51) and language domains (β = 6.51) (all p < 0.05). Bayesian kernel machine regression (BKMR) showed consistent positive exposure responses for 1‐OHNap, 1‐OHPhe, and 3 + 9‐OHPhe levels in regard to CARS scores, and for 1‐OHPyr levels in regard to ABC total scores. Our findings suggest that children with ASD may have higher urinary levels of hydroxy‐PAHs, and that these biomarker levels are associated with an increased odds of ASD, an increased severity of autism symptomology, and increased autistic behaviors in children with autism.Lay summaryWe conducted an epidemiologic study evaluating the associations of urinary hydroxy‐PAH levels with autism spectrum disorder (ASD), autism symptomology, and autistic behaviors. We found that urinary hydroxy‐PAHs were statistically significantly associated with ASD. We note strong statistically significant associations between 1‐OHNap, 1‐OHPhe, and 3 + 9‐OHPhe levels and increased severity of autism symptomology, as well as a strong statistically significant association between 1‐OHPyr levels and behavioral characteristics within the social and linguistic domains. This work, if confirmed, will contribute to the future development of diagnostics for children with mild autism, as well as to environmental measures to promote the health and wellbeing of children with autism spectrum disorders.
Development and validation of a liquid chromatography coupled with tandem mass spectrometry method for determining total and unbound pamiparib in human plasma and brain tumors
Authors: Jiang Jun , Bao Xun , Yue Yang , Schiff David , Bindra Ranjit , Li Jing 
Published: August 2022

AbstractPamiparib (BGB‐290) is an orally bioavailable, small molecule inhibitor of poly (ADP‐ribose) polymerase 1 (PARP1) and PARP2. A reversed‐phase LC with tandem mass spectrometry method was developed and fully validated for determining total and unbound pamiparib concentrations in human plasma and brain tumor tissue. Plasma and tissue homogenate samples were prepared by methanol protein precipitation. Pamiparib and the internal standard [13C2,15N2]pamiparib were separated on a Waters BEH C18 (50 × 2.1 mm, 1.7 μm) column, with a gradient elution consisting of mobile phases A (0.1% formic acid in water) and B (0.1% formic acid in acetonitrile) at a flow rate of 0.25 mL/min. The analytes were monitored with multiple reaction monitoring mode under positive electrospray ionization. The method was fully validated for specificity, linearity, accuracy and precision, matrix effect and recovery, and short‐ and long‐term stability. The lower limit of quantitation was 0.5 nM of pamiparib in plasma or tissue homogenate. The calibration curve was linear over the pamiparib concentration range of 0.5–1000 nM in plasma. The intra‐ and inter‐day precision and accuracy were within the generally accepted criteria for bioanalytical method. Pamiparib was stable in plasma at −80°C for at least 6 months. The method was successfully applied to assess the plasma and tumor pharmacokinetics of total and unbound pamiparib in patients with glioma.
Neuropsychiatric Inventory domains cluster into neuropsychiatric syndromes in Alzheimer's disease: A systematic review and meta‐analysis
Authors: Hiu Shaun Kuan Wei , Bigirumurame Theophile , Kunonga Patience , Bryant Andrew , Pillai Manjunadh 
Published: August 2022

AbstractBackground: Studies of patients with Alzheimer's disease (AD) have observed that neuropsychiatric symptoms (NPS) tend to co‐occur as neuropsychiatric syndromes and have generally shown mixed results regarding the number and composition of syndromes. We systematically reviewed how neuropsychiatric syndromes in AD have been defined and compared the different published definitions in a pooled sample of AD patients using meta‐analytic structural equation modeling (MASEM).Methods: Studies examining the factor structure of the Neuropsychiatric Inventory (NPI) and published from 1994 to 2021 were included. We contacted the corresponding authors of eligible studies for correlation coefficients between NPI items. We pooled correlations under a random effects MASEM model and fitted and compared measurement models from published studies to identify a best‐fitting model.Results: Twenty‐five studies were included in the systematic review, and correlations were obtained from seven studies for MASEM. For the NPI‐10 (seven studies, n = 5185), a five‐factor structure was found to have a good fit to the data. For the NPI‐12 (four studies, n = 2397), we were unable to identify a factor structure that displayed a good model fit.Conclusion: This systematic review and meta‐analysis contribute to the development of a theoretical model of neuropsychiatric syndromes in AD and reveals the barriers that accompany MASEM methodology.
Genotype–phenotype characteristics of Vietnamese patients diagnosed with Charcot–Marie–Tooth disease
Authors: Nguyen‐Le Trung‐Hieu , Do Minh Duc , Le Linh Hoang Gia , Nhat Quynh Nhu Nguyen , Hoang Nghia Trong Tien , Van Le Tuan , Mai Thao Phuong 
Published: August 2022

AbstractBackgroundCharcot–Marie‐Tooth (CMT) disease is one of the most common hereditary neuropathies. Identifying causative mutations in CMT is essential as it provides important information for genetic diagnosis and counseling. However, genetic information of Vietnamese patients diagnosed with CMT is currently not available.MethodsIn this study, we described the clinical profile and determined the mutation spectrum of CMT in a cohort of Vietnamese patients with CMT by using a combination of multiplex ligation‐dependent probe amplification and next‐generation sequencing targeting 11 genes PMP22, MPZ, EGR2, NEFL, MFN2, GDAP1, GARS, MTMR2, GJB1, RAB7A, LITAF.ResultsIn 31 CMT cases, the mutation detection rate was 42% and the most common genetic aberration was PMP22 duplication. The pedigree analysis showed two de novo mutations c.64C > A (p.P22T) and c.281delG (p.G94Afs*17) in the NEFL and PMP22 genes, respectively.ConclusionThe results of this study once again emphasize the important role of molecular diagnosis and provide preliminary genetic data on Vietnamese patients with CMT.
Nanostructured anatase TiO2 as anode of high‐performance lithium‐ion batteries
Authors: Paul Sourav , Rahman Md. Arafat , Islam Md. Saiful , Islam Md. Rasidul , Siddiqui Safina‐E‐Tahura 
Published: August 2022

AbstractNanostructured anatase TiO2 (NSA‐TiO2) was synthesized via electrochemical anodization of pure Ti foils in a fluorine‐containing electrolyte. The synergistic effects of the anodization period (1 and 2 h) and the surface condition of Ti foils (scratched and unscratched) before anodization was investigated. Four nanostructure variants—unscratched 1 h, unscratched 2 h, scratched 1 h, and scratched 2 h with average pore diameters 15 ± 7.4, 10.1 ± 8.5, 7 ± 7.12, and 8.1 ± 3.79 nm, respectively, were fabricated to assess as negative electrodes of high‐performance lithium‐ion batteries (LIBs). The corresponding first cycle discharge capacities of as‐synthesized NSA‐TiO2 exhibited 433, 93.33, 453.33, and 460.0 mAhg−1. LIB with scratched 1 h NSA‐TiO2 as anode exhibited very propitious outcomes. The reversible capacity at a high 1 C current rate was displayed as 100 mAhg−1 even after 400 cycles along with 103.27% coulombic efficiency. The superior electrochemical performances are attributed to its high specific surface area due to its nanoporous structure. These nanoporous structures provide higher contact between electrodes and electrolytes, shortening the diffusion pathways for conductive ions and electrons that ensured faster kinetics. However, scratching operations increased surface area in the final nanostructure while the short anodization period substantially increased the number of pores.
Opportunities and challenges of immune checkpoint inhibitors for extensive‐stage small‐cell lung cancer
Authors: Zhao Jing , Zhuo Xiaoli , Liu Lei , Yang Zhe , Fu Guobin 
Published: August 2022

AbstractSmall‐cell lung cancer (SCLC) accounts for 15%–20% of primary lung cancers, and it is characterized by low differentiation, rapid proliferation, and early metastasis. At least two‐thirds of SCLC patients present with the extensive stage (ES) at the time of initial clinical diagnosis. Over the last 2 decades, platinum‐based combination chemotherapy has remained the standard first‐line treatment for SCLC. With the introduction of the immunotherapy era, immunotherapy plus chemotherapy has replaced conventional chemotherapy as the first‐line treatment option for ES‐SCLC and is recommended by National Comprehensive Cancer Network clinical guidelines. Therefore, in this review, we present the latest research advances in SCLC treatment, predictive biomarkers, and other topics of high interest to provide options for patients with SCLC.
Social, health and ethnicity correlates of complaints of excessive police force
Authors: Smith Sven , Ferguson Christopher J. , San Miguel Claudia E. , Ynalvez Marcus Antonius , Henderson Howard 
Published: August 2022

AbstractBackgroundFollowing several high‐profile police shootings of Black Americans, renewed debate has focused on race as a predictor of police violence. Past research has been inconsistent on this score. Some scholars argue that socioeconomic issues are better predictors of police‐related violence than are race and ethnicity.AimsTo test relationships between complaints of excessive use of police violence and racial/ethnic population demographics, allowing for social and mental health variables.MethodsWe examined records from all 195 municipal police departments in California to identify complaints of excessive force by police and tested for associations between such complaints and health, socio‐economic and demographic data from county records, using multivariate analyses.ResultsThere was no difference in reporting between communities according to Black or White American residency proportions; communities with more Latino Americans were less likely to complain formally of excessive use of police force. The strongest associate of complaints to police departments that their employees had used excessive force was experiencing mental distress in the community.ConclusionsOur findings are limited by reliance on complaints to police authorities rather than actual incidence of police use of excessive force and by having to map municipal data on to county data, but the finding that factors other than or in addition to any inherent police problems may contribute to excessive use of force by the police offers new lines for remedying the problem. In particular, our findings suggest that more training for police in recognising and managing mental distress and more provision of mental health experts to work alongside police would be worth evaluating as a next step.
Calcinosis of the internal jugular vein: Interesting presentation of tertiary hyperparathyroidism
Authors: Shires Courtney B. , Shete Mona 
Published: August 2022

AbstractTumoral calcinosis is a severe complication of hemodialysis. A 49‐year‐old male on dialysis for end‐stage renal disease developed a large calcified retropharyngeal mass. This caused stridor and dyspnea, necessitating an emergency awake tracheostomy. This is the first report of internal jugular vein calcinosis. Surgery is recommended.
Coronavirus disease 19 (COVID‐19) and Cerebral venous sinus thrombosis (CVST): A case series and review of the literature
Authors: Kallel Nesrine , Saidani Amal , Kotti Amina , Moussa Nedia , Maddeh Sabrine , Gargouri Rahma , Msaad Sameh , Feki Walid 
Published: August 2022

AbstractA large proportion of patients with coronavirus disease 19 (COVID‐19) suffer from excessive coagulation activation and coagulopathy which predisposes them to a wide spectrum of thrombotic events including in situ pulmonary thrombosis, deep‐vein thrombosis, and associated pulmonary embolism, as well as arterial thrombotic events. Cerebral venous sinus thrombosis (CVST) have also been reported but in a very small number of cases. This report aims to increase awareness about CVST as a potential neurological thromboembolic complication in patients with coronavirus disease. We report three COVID‐19 patients presenting with CVTS. We also review all previously described cases and present an overview of their demographic, clinical, and diagnostic data. We describe three patients with concomitant coronavirus disease and CVST among 1000 hospitalized COVID‐19 patients (2 males, 1female, and mean age of 37 years). One patient was previously healthy, while the two others had a history of chronic anemia and ulcerative colitis, respectively. CVST symptoms including seizure in two patients and headache in one patient occurred day to weeks after the onset of COVID‐19 symptoms. Three months of anticoagulant therapy was given for all three patients with favorable outcomes. No neurological sequelae and no recurrence occurred within 6 months after hospital discharge. Our search identified 33 cases of COVID‐19 complicated by CVST. The mean age was 45.3 years, there was a slight male predominance (60%), and more than half of cases were diagnosed in previously healthy individuals. All cases of CVT were clinically symptomatic and were observed in patients with a different spectrum of coronavirus disease severity. Headache was the most common complaint, reported by just less than half of patients. There was a high mortality rate (30.3%). CVT is a very rare, but potentially life‐threatening complication in patients with COVID‐19. It's mainly reported in relatively young individuals with no or little comorbid disease and can occur even in patients who do not display severe respiratory symptoms. Atypical clinical presentations may pose a challenge to the early diagnosis and treatment. High suspicion is necessary as early diagnosis and prompt treatment with anticoagulation in all patients with COVID‐19 and CVT could contain the mortality rate and improve neurological outcomes in these patients.
Modeling Electrochemical Proton Adsorption at Constant Potential with Explicit Charging
Authors: Kristoffersen Henrik H. 
Published: August 2022

AbstractAn explicit charging approach is presented to account for constant potential in atomic level electrochemistry modeling. Explicit charging allows for the calculation of electrochemical reaction barriers, while also reproducing the results from the computation hydrogen electrode (CHE) approach when the reaction modeled with CHE is at constant potential. Explicit charging is used to obtain activation and adsorption free energies for proton adsorption (the Volmer reaction) from a static water bilayer to the Cu(111) surface. The proton adsorption becomes spontaneous at around 0 V vs RHE and the adsorption free energy changes by around 1 eV per V (similar to the CHE result). The activation free energy changes by around 0.5 eV per V, but is still prohibitively large at 0 V vs RHE. This is consistent with experiments, where hydrogen evolution is only observed below −0.4 V vs RHE.
Synthesis of Enantioenriched Sulfoxides by an Oxidation‐Reduction Enzymatic Cascade
Authors: Wang Peipei , Han Xiaofeng , Liu Xinqi , Lin Richen , Chen Yongzheng , Sun Zhoutong , Zhang Wuyuan 
Published: August 2022

AbstractChiral sulfoxides are versatile synthons and have gained a particular interest in asymmetric synthesis of active pharmaceutical and agrochemical ingredients. Herein, a linear oxidation–reduction bienzymatic cascade to synthesize chiral sulfoxides is reported. The extraordinarily stable and active vanadium‐dependent chloroperoxidase from Curvularia inaequalis (CiVCPO) was used to oxidize sulfides into racemic sulfoxides, which were then converted to chiral sulfoxides by highly enantioselective methionine sulfoxide reductase A (MsrA) and B (MsrB) by kinetic resolution, respectively. The combinatorial cascade gave a broad range of structurally diverse sulfoxides with excellent optical purity (>99 %  ee) with complementary chirality. The enzymatic cascade requires no NAD(P)H recycling, representing a facile method for chiral sulfoxide synthesis. Particularly, the envisioned enzymatic cascade not only allows CiVCPO to gain relevance in chiral sulfoxide synthesis, but also provides a powerful approach for (S)‐sulfoxide synthesis; the latter case is significantly unexplored for heme‐dependent peroxidases and peroxygenases.
Vinylic Trifluoromethylselenolation via Pd‐Catalyzed C−H Activation
Authors: de Zordo‐Banliat Arnaud , Grollier Kevin , Vigier Jordan , Jeanneau Erwann , Dagousset Guillaume , Pegot Bruce , Magnier Emmanuel , Billard Thierry 
Published: August 2022

AbstractTrifluorometylselenolation via C−H activation is barely described in literature. In particular, no such vinylic functionalization has been yet described. Herein, a palladium‐catalyzed trifluoromethylselenolation of vinylic C−H bonds is described. The 5‐methoxy‐8‐aminoquinoline has been used as auxiliary directing group to perform this reaction. The reaction gives excellent yields with α‐substituted compounds whatever the substituents and a microwave activation can be used to accelerate the reaction. With β‐substituted substrates lower yields, but still satisfactory, are obtained. This methodology was also successfully extended to other fluoroalkylselenyl groups.
Pru du 1, the Bet v 1‐homologue from almond, is a major allergen in patients with birch pollen associated almond allergy
Authors: Kabasser Stefan , Crvenjak Nadja , Schmalz Stefanie , Kalic Tanja , Hafner Christine , Dubiela Pawel , Kucharczyk Aleksandra , Bazan‐Socha Stanislawa , Lukaszyk Mateusz , Breiteneder Heimo , Radauer Christian , Bublin Merima 
Published: August 2022

AbstractBackgroundAlmond allergy is common and can manifest in two different forms. Primary almond allergy has been reported to be associated with sensitization to almond legumin Pru du 6. In birchendemic regions, there is a link between birch‐pollinosis which is likely based on a cross‐reactive Bet v 1 homologue, a yet unidentified allergen in almond. Therefore, we sought to identify and characterize a Bet v 1‐homologue in almond.MethodsThe expression of a Bet v 1 homologue in almond kernels was confirmed by mass spectrometry. The recombinant protein was produced in Escherichia coli and its cross‐reactivity and allergenic potency was analyzed by IgE quantitative and competitive ELISA, immunoblotting and basophil histamine release using sera from 17 almond allergic patients.ResultsThe identified Bet v 1 homologue received the designation Pru du 1.0101. Pru du 1.0101 bound IgE from 82 % of almond allergic patients. Bet v 1 was able to inhibit IgE‐binding to rPru du 1 by 100%, while rPru du 1 inhibited IgE binding to rBet v 1 by 48%. Pru du 1.0101 activated basophils, though 100‐ to 1000‐fold higher concentrations were required for maximum activation in comparison to rBet v 1.ConclusionConsidering the strong inhibition capacity and higher allergenic potency of Bet v 1, the results provide compelling evidence for primary sensitization to Bet v 1 in case of birch pollen associated almond allergy. Combining Pru du 6 and Pru du 1 in diagnostic approaches may help to discriminate between primary and birch‐pollen associated almond allergy.
A brain atlas of the carrion crow (Corvus corone)
Authors: Kersten Ylva , Friedrich‐Müller Bettina , Nieder Andreas 
Published: August 2022

AbstractCorvidae, passerine songbirds such as jays, crows, and ravens known as corvids, have become model systems for the study of avian cognition. The superior cognitive capabilities of corvids mainly emerge from a disproportionally large telencephalon found in these species. However, a systematic mapping of the neuroanatomy of the corvid brain, and the telencephalon in particular, is lacking so far. Here, we present a brain atlas of the carrion crow, Corvus corone, with special emphasis on the telencephalic pallium. We applied four staining techniques to brain slices (Nissl, myelin, combination of Nissl and myelin, and tyrosine hydroxylase targeting catecholaminergic neurons). This allowed us to identify brain nuclei throughout the brain and delineate the known pallial subdivisions termed hyperpallium, entopallium, mesopallium, nidopallium, arcopallium, and hippocampal complex. The extent of these subdivisions and brain nuclei are described according to stereotaxic coordinates. In addition, 3D depictions of pallial regions were reconstructed from these slices. While the overall organization of the carrion crow's brain matches other songbird brains, the relative proportions and expansions of associative pallial areas differ considerably in agreement with enhanced cognitive skills found in corvids. The presented global organization of the crow brain in stereotaxic coordinates will help to guide future neurobiological studies in corvids.
A Porphyrin‐functionalized Graphene Oxide Nanocomposite for Simultaneous Detection of Dopamine and Uric Acid
Authors: Wei Chuangyu , Tu Jingfang , Liu Hanqi , Mei Zhuang , Gao Xinyu , Yu Jinshi , Cai Xue , Li Xiyou , Chen Yanli 
Published: August 2022

AbstractCarbon nanomaterials combined with porphyrins having the similar electrocatalytic active center to heme protein are quite promising for high‐performance nonenzymatic electrochemical sensor. Herein, the catalytic tetra(4‐aminophenyl) porphyrin (TAPP) molecules are covalent immobilized on the conductive graphene oxide (GO) surface (TAPP@GO) by a simple one‐pot method. TAPP@GO as a novel electrochemical sensor successfully realized the sensitive detection of dopamine (DA) and uric acid (UA) in nM level with high stability and repeatability. The detection limit (LOD) for DA and UA is as low as 38 and 47 nM, and sensitivity up to 40.3 and 54.2 μA mM−1 in a wide detection range from 0.1 to 350 μM, respectively. Impressively, both DA and UA in the coexistence system can be simultaneously determined with the LOD of 51 and 64 nM for DA and UA, which is further confirmed by accurate determination of both in urine samples. This work represents not only the first example of electrochemical sensor based on organic porphyrin molecules covalent linked on GO surface, but more importantly provides an effective method for developing high‐performance sensing materials.