bluuebunny/crossref_metadata_2025_split huggingface dataset:
Providence and Narrative in the Theology of John Chrysostom
Authors: Edwards Robert 
Published: December 2022

This book is the first major study of providence in the thought of John Chrysostom, a popular preacher in Syrian Antioch and later archbishop of Constantinople (ca. 350 to 407 CE). While Chrysostom is often considered a moralist and exegete, this study explores how his theology of providence profoundly affected his larger ethical and exegetical thought. Robert Edwards argues that Chrysostom considers biblical narratives as vehicles of a doctrine of providence in which God is above all loving towards humankind. Narratives of God's providence thus function as sources of consolation for Chrysostom's suffering audiences, and may even lead them now, amid suffering, to the resurrection life-the life of the angels. In the course of surveying Chrysostom's theology of providence and his use of scriptural narratives for consolation, Edwards also positions Chrysostom's theology and exegesis, which often defy categorization, within the preacher's immediate Antiochene and Nicene contexts.
Class, Whiteness, and Southern Literature
Authors: Hubbs Jolene 
Published: December 2022

Class, Whiteness, and Southern Literature explores the role that representations of poor white people play in shaping both middle-class American identity and major American literary movements and genres across the long twentieth century. Jolene Hubbs reveals that, more often than not, poor white characters imagined by middle-class writers embody what better-off people are anxious to distance themselves from in a given moment. Poor white southerners are cast as social climbers during the status-conscious Gilded Age, country rubes in the modern era, racist obstacles to progress during the civil rights struggle, and junk food devotees in the health-conscious 1990s. Hubbs illuminates how Charles Chesnutt, William Faulkner, Flannery O'Connor, Dorothy Allison, and Barbara Robinette Moss swam against these tides, pioneering formal innovations with an eye to representing poor white characters in new ways.
Association between job role and coronavirus disease 2019 (COVID-19) among healthcare personnel, Iowa, 2021
Authors: Kobayashi Takaaki , Trannel Alexandra , Heinemann John , Marra Alexandre R. , Etienne William , Abosi Oluchi J. , Holley Stephanie , Dains Angelique , Jenn Kyle E. , Meacham Holly , Schuessler Barbara A. , Wendt Linder , Ten Eyck Patrick , Hanna Beth , Salinas Jorge L. , Hartley Patrick G. , Ford Bradley , Wellington Melanie , Brust Karen B. , Diekema Daniel J. 
Published: December 2022

Abstract
We describe the association between job roles and coronavirus disease 2019 (COVID-19) among healthcare personnel. A wide range of hazard ratios were observed across job roles. Medical assistants had higher hazard ratios than nurses, while attending physicians, food service workers, laboratory technicians, pharmacists, residents and fellows, and temporary workers had lower hazard ratios.
Writing in Englishes: Taking Control of the Technology of Power through Literary Aesthetics: A Keynote Speech to the African Studies Association Conference, 2021
Authors: Forna Aminatta 
Published: December 2022

AbstractAs language increasingly becomes uncoupled from the nation state, transnational writers, transnational African writers, and African writers are using language to serve their own purposes and creating new literary aesthetics. This essay, first given as a keynote speech to the 2021 African Studies Association Annual Conference, examines some debates about the relationship between language and power and argues that these are being upended by writers who do not fit conventional categories, including transnational African writers. These writers are exploring the range of options presented by their own multilingualism and making unapologetic aesthetic claims upon the English language.
Citizen science and land use data provide insight into the invasive riparian plant composition of the Hudson River Valley watershed
Authors: Garretson Alexis , Mohney Samantha , Cahill Morgan , Griffin Laurel , Silarszka Rachel ,   Stream Watch Citizen Scientists Mohonk Preserve, Feldsine Natalie , Napoli Megan N. , Long Elizabeth C. 
Published: December 2022

AbstractInvasive plants in the riparian zone can negatively affect the characteristics and quality of a watershed. To support the development of a watershed management plan and foster public appreciation of the value of the riparian zone, Mohonk Preserve established a volunteer monitoring program surveying sites for invasive species. Between 2017 and 2019, citizen scientists repeatedly surveyed 20 sites in the Hudson River Valley in New York for 10 invasive plant species: purple loosestrife (Lythrum salicaria L.), common reed [Phragmites australis (Cav.) Trin. ex Steud], multiflora rose (Rosa multiflora Thunb.), garlic mustard [Alliaria petiolata (M. Bieb.) Cavara & Grande], dame’s rocket (Hesperis matronalis L.), Japanese knotweed (Polygonum cuspidatum Siebold & Zucc.), wineberry (Rubus phoenicolasius Maxim.), barberry (Berberis spp.), Japanese stiltgrass [Microstegium vimineum (Trin.) A. Camus], and Asiatic bittersweet (oriental bittersweet, Celastrus orbiculatus Thunb.). We found that the number of target species detected was higher on sites closer to paved roads and with increasing drainage area size, while lower with higher percentages of forested land in the basin. Our analysis results highlight variation in the presence of target invasive species across the Hudson River Valley region, highlighting sites and areas to monitor for future introductions and take action to prevent species’ invasions. Our results highlight differences in the most relevant abiotic factors for hydrophytes and non-hydrophyte species, underscoring the importance of considering species’ life-history traits before the development of management plans for invasive plant species in the riparian zone. Our case study of community-collected data in the Hudson River Valley region using a relatively simple monitoring protocol can provide a road map for other regions fostering volunteer engagement with invasive plants.
Dominant role of deglaciation in Late Pleistocene–Early Holocene sediment aggradation in the Upper Chenab valley, NW Himalaya
Authors: Dey Saptarshi , Chauhan Naveen , Mahala Milan Kumar , Chakravarti Pritha , Vashistha Anushka , Jain Vikrant , Ray Jyotiranjan S. 
Published: December 2022

AbstractSediment transfer from the interiors of the Himalaya is complex because the archives are influenced by both glacial and monsoonal cycles. To deconvolve the coupling of glacial and monsoonal effects on sediment transfer processes, we investigate the Late Pleistocene–Holocene sediment archive in the Upper Chenab valley. Optically stimulated luminescence (OSL) ages from the archive indicate major aggradation during ca. 20–10 ka. Isotopic fingerprinting using Sr-Nd isotopes in silt fractions together with clast counts in boulder-pebble fractions indicate a decreasing Higher Himalayan sediment flux in the archive with time. Decreasing clast size, increasing clast roundness, increasing matrix to clast ratio, and dominance of the Higher Himalayan sourcing unequivocally suggest strong glacial influence during the initial stages of the archive formation. This evidence also agrees with the existing retreat ages of glaciers in the Upper Chenab valley. Results of our study also show that the upper parts of the archive contain significant fluvial sediment contribution from the Lesser Himalaya, which suggests an active role of the stronger Indian Summer Monsoon (ISM) in the region during the Early Holocene. The apparent decrease in sediment supply from the Higher Himalayan sources could have been due to longer source-to-sink transport in the Early Holocene and/or increased hillslope flux from Lesser Himalayan sources.
Social memory and the impact of commemorative remedies ordered by the Inter-American Court of Human Rights
Authors: Hirsch Moshe , Said Barguil Milad A. 
Published: December 2022

AbstractSocial memory studies start from the premise that people acquire their memories not only through individual means, but through social processes as well. Social groups often provide materials for memory, and prod individuals into recalling particular events. One of the distinctive differences between the practice of the Inter-American Court of Human Rights (IACtHR) and the European Court of Human Rights (ECtHR) concerns memory-related remedies. While the IACtHR quite frequently orders respondent states to commemorate grave violations of human rights (including the construction of monuments), the ECtHR has refrained from granting such commemorative remedies. Some organizations representing victims have called upon additional tribunals to embrace the IACtHR’s remedial approach to address grave breaches of international law. Drawing on social memory scholarship, this study is aimed at empirically assessing the impact of four sites of memory in Colombia established by order of the IACtHR. The study’s findings suggest that international tribunals alone cannot shape collective memories that are inconsistent with sociocultural features characterizing the local society. On the other hand, judicially-ordered sites of memory are meaningful for the victims’ families and small-scale social units. These findings turn our attention to micro-level sociological perspectives, and particularly to the symbolic-interactionist approach to international law, highlighting the vital symbolic role of international tribunals for individuals and small social units. The valuable role of such memorial sites for the victims’ relatives and related communities suggests that international tribunals addressing grave human rights violations should consider granting commemorative remedies.
A social-development model of the evolution of depressive symptoms from age 13 to 30
Authors: Allen Joseph P. , Pettit Corey , Costello Meghan A. , Hunt Gabrielle L. , Stern Jessica A. 
Published: December 2022

AbstractThis 17-year prospective study applied a social-development lens to the challenge of identifying long-term predictors of adult depressive symptoms. A diverse community sample of 171 individuals was repeatedly assessed from age 13 to age 30 using self-, parent-, and peer-report methods. As hypothesized, competence in establishing close friendships beginning in adolescence had a substantial long-term predictive relation to adult depressive symptoms at ages 27–30, even after accounting for prior depressive, anxiety, and externalizing symptoms. Intervening relationship difficulties at ages 23–26 were identified as part of pathways to depressive symptoms in the late twenties. Somewhat distinct paths by gender were also identified, but in all cases were consistent with an overall role of relationship difficulties in predicting long-term depressive symptoms. Implications both for early identification of risk as well as for potential preventive interventions are discussed.
Genetic diversity of Greek grapevine (Vitis viniferaL.) cultivars using ampelographic and microsatellite markers
Authors: Tsivelikas Athanasios L. , Avramidou Evangelia V. , Ralli Parthenopi E. , Ganopoulos Ioannis V. , Moysiadis Theodoros , Kapazoglou Aliki , Aravanopoulos Filippos A. , Doulis Andreas G. 
Published: December 2022

AbstractGrapevine (Vitis viniferaL.) is a major worldwide crop of high economic importance, tightly interwoven with the traditions and the culture of many civilizations. The Greek vineyard is one of the oldest in the world composed of an ample number of highly diverse indigenous landraces. However, over the last decades the local cultivated grapevine germplasm has undergone a drastic reduction of diversity, due to the established market preferences for international varieties. In the current work a combined approach involving both, ampelographic traits and microsatellite markers has been undertaken, to study the genetic diversity within and among 96 grapevine genotypes belonging to 36V. viniferasubsp.viniferacultivars, predominantly representing autochthonous Greek landraces. Results revealed high genetic diversity for the Greek cultivars yielding a mean number of alleles per locus 14.69 and mean polymorphic information content 0.848. Hierarchical cluster analysis, employing both, ampelographic and microsatellite data, showed a clear distinction based on the origin of the germplasm; Anatolian versus Mediterranean. Principal component analysis, based on the most informative ampelographic traits, coupled to the results from genetic structure analysis further corroborated the proposal of germplasm differentiation on the basis of geographic origin. This information can be further utilized for the reconstitution of the Greek vineyard and can significantly contribute towards a rational conservation and utilization strategy for breeding or for direct cultivation of the Greek indigenous grapevine germplasm.
The Delayed Response of the Troposphere‐Stratosphere‐Mesosphere Coupling to the 2019 Southern SSW
Authors: Yang Chengyun , Li Tao , Lai Dexin , Wang Xinyue , Xue Xianghui , Dou Xiankang 
Published: December 2022

AbstractA strong Southern Hemisphere (SH) sudden stratospheric warming event occurred in September 2019 and significantly weakened the stratospheric polar vortex. Due to the positive zonal wind anomalies in the troposphere, the barotropic/baroclinic instability, primarily controlled by the horizontal/vertical wind shear, weakened in the upper troposphere at midlatitudes in late September and early October. As a result, planetary waves (PWs) were deflected equatorward near the tropopause rather than upward into the stratosphere, resulting in less perturbation to the stratospheric polar vortex. After October 15, the westward zonal wind anomalies propagate downward and reach the troposphere, increasing the tropospheric barotropic/baroclinic instability. This benefits the propagation of PWs into the stratosphere, leading to the early breaking of the stratospheric polar vortex. In turn, the SH mesosphere becomes anomalously cold due to the stratospheric wind filtering on the gravity waves, leading to the much earlier onset of SH polar mesospheric clouds.
The Transformation and Export of Organic Carbon Across an Arctic River‐Delta‐Ocean Continuum
Authors: Clark J. Blake , Mannino Antonio , Tzortziou Maria , Spencer Robert G. M. , Hernes Peter 
Published: December 2022

AbstractThe Arctic Ocean is surrounded by land that feeds highly seasonal rivers with water enriched in high concentrations of dissolved and particulate organic carbon (DOC and POC). Explicit estimates of the flux of organic carbon across the land‐ocean interface are difficult to quantify and many interdependent processes makes source attribution difficult. A high‐resolution 3‐D biogeochemical model was built for the lower Yukon River and coastal ocean to estimate biogeochemical cycling across the land‐ocean continuum. The model solves for complex reactions related to organic carbon transformation, including mechanistic photodegradation and multi‐reactivity microbial processing, DOC–POC flocculation, and phytoplankton dynamics. The baseline DOC and POC flux out of the delta from April to September 2019, was 977 and 536 Gg C (∼80% of the annual total), but only 50% of the DOC and 25% of the POC exited the plume across the 10 m isobath. Microbial breakdown of DOC accounted for a net loss of 168 Gg C (17% of delta export) within the plume and photodegradation accounted for a net loss of 46.6 Gg C DOC (5% of delta export) in 2019. Flocculation decreased the total organic carbon flux by only 6.4 Gg C (∼1%), while POC sinking accounted for 63.3 Gg C (10%) settling in the plume. The loss of chromophoric dissolved organic matter due to photodegradation increased the light available for phytoplankton growth throughout the coastal ocean, demonstrating the secondary effects that organic carbon reactions can have on biological processes and the net coastal carbon flux.
Neural underpinnings of open-label placebo effects in emotional distress
Authors: Schaefer Michael , Kühnel Anja , Schweitzer Felix , Enge Sören , Gärtner Matti 
Published: December 2022

AbstractWhile placebo effects are well-known, research in the last decade revealed intriguing effects that placebos may have beneficial effects even when given without deception. At first glance, this seems paradoxical, but several studies have reported improvements in pain, depression, or anxiety. However, it still remains unclear whether these results represent objective biological effects or simply a bias in response and what neural underpinnings are associated with the open-label placebo effects. In two studies, we address this gap by demonstrating that open-label placebos reduce self-reported emotional distress when viewing highly arousing negative pictures. This reduced emotional distress was associated with an activation of brain areas known to modulate affective states such as the periaqueductal gray, the bilateral anterior hippocampi, and the anterior cingulate cortex. We did not find any prefrontal brain activation. Furthermore, brain activation was not associated with expectation of effects. In contrast, we found that brain responses were linked to general belief in placebos. The results demonstrate that the neural mechanisms of open-label placebo effects are partly identical to the neurobiological underpinnings of conventional placebos, but our study also highlights important differences with respect to a missing engagement of prefrontal brain regions, suggesting that expectation of effects may play a less prominent role in open-label placebos.
The metabolic regulator USF-1 is involved in the control of affective behaviour in mice
Authors: Sideromenos Spyros , Nikou Maria , Czuczu Barbara , Thalheimer Nikolas , Gundacker Anna , Horvath Orsolya , Cuenca Rico Laura , Stöhrmann Peter , Niello Marco , Partonen Timo , Pollak Daniela D. 
Published: December 2022

AbstractEpidemiological studies indicate a bidirectional association between metabolic disturbances, including obesity and related pathological states, and mood disorders, most prominently major depression. However, the biological mechanisms mediating the comorbid relationship between the deranged metabolic and mood states remain incompletely understood. Here, we tested the hypothesis that the enhanced activation of brown fat tissue (BAT), known to beneficially regulate obesity and accompanying dysfunctional metabolic states, is also paralleled by an alteration of affective behaviour. We used upstream stimulatory factor 1 (USF-1) knock-out (KO) mice as a genetic model of constitutively activated BAT and positive cardiometabolic traits and found a reduction of depression-like and anxiety-like behaviours associated with USF-1 deficiency. Surgical removal of interscapular BAT did not impact the behavioural phenotype of USF-1 KO mice. Further, the absence of USF-1 did not lead to alterations of adult hippocampal neural progenitor cell proliferation, differentiation, or survival. RNA-seq analysis characterised the molecular signature of USF-1 deficiency in the hippocampus and revealed a significant increase in the expression of several members of the X-linked lymphocyte-regulated (xlr) genes, including xlr3b and xlr4b. Xlr genes are the mouse orthologues of the human FAM9 gene family and are implicated in the regulation of dendritic branching, dendritic spine number and morphology. The transcriptional changes were associated with morphological alterations in hippocampal neurons, manifested in reduced dendritic length and complexity in USF-1 KO mice. Collectively these data suggest that the metabolic regulator USF-1 is involved in the control of affective behaviour in mice and that this modulation of mood states is unrelated to USF-1-dependent BAT activation, but reflected in structural changes in the brain.
Acetylation of Checkpoint suppressor 1 enhances its stability and promotes the progression of triple-negative breast cancer
Authors: Xu Zhaowei , Liu Shuyan , Feng Chun , Xu Fuyi , Kong Demin , Mi Jia , Yang Chunhua , Zhang Guilong , Wei Pengfei , Orgil Buyan-Ochir , Bergquist Jonas , Tian Geng 
Published: December 2022

AbstractCheckpoint suppressor 1 (CHES1), a transcriptional regulator, had been dysregulated in many types of malignancies including breast cancer, and its expression level is strongly associated with progression and prognosis of patients. However, the underlying regulatory mechanisms of CHES1 expression in the breast cancer and the effects of post-translational modifications (PTMs) on its functional performance remain to be fully investigated. Herein, we found that CHES1 had a high abundance in triple-negative breast cancer (TNBC) and its expression was tightly associated with malignant phenotype and poor outcomes of patients. Furthermore, we confirmed that CHES1 was an acetylated protein and its dynamic modification was mediated by p300 and HDAC1, and CHES1 acetylation enhanced its stability via decreasing its ubiquitination and degradation, which resulted in the high abundance of CHES1 in TNBC. RNA-seq and functional study revealed that CHES1 facilitated the activation of oncogenic genes and pathways leading to proliferation and metastasis of TNBC. Taken together, this research established a novel regulatory role of acetylation on the stability and activity of CHES1. The results demonstrate the significance of CHES1 acetylation and underlying mechanisms in the progression of TNBC, offering new potential candidate for molecular-targeted therapy in breast cancer.
A self-powered ingestible wireless biosensing system for real-time in situ monitoring of gastrointestinal tract metabolites
Authors: De la Paz Ernesto , Maganti Nikhil Harsha , Trifonov Alexander , Jeerapan Itthipon , Mahato Kuldeep , Yin Lu , Sonsa-ard Thitaporn , Ma Nicolas , Jung Won , Burns Ryan , Zarrinpar Amir , Wang Joseph , Mercier Patrick P. 
Published: December 2022

AbstractInformation related to the diverse and dynamic metabolite composition of the small intestine is crucial for the diagnosis and treatment of various diseases. However, our current understanding of the physiochemical dynamics of metabolic processes within the small intestine is limited due to the lack of in situ access to the intestinal environment. Here, we report a demonstration of a battery-free ingestible biosensing system for monitoring metabolites in the small intestine. As a proof of concept, we monitor the intestinal glucose dynamics on a porcine model. Battery-free operation is achieved through a self-powered glucose biofuel cell/biosensor integrated into a circuit that performs energy harvesting, biosensing, and wireless telemetry via a power-to-frequency conversion scheme using magnetic human body communication. Such long-term biochemical analysis could potentially provide critical information regarding the complex and dynamic small intestine metabolic profiles.
PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response
Authors: Andrysik Zdenek , Sullivan Kelly D. , Kieft Jeffrey S. , Espinosa Joaquin M. 
Published: December 2022

AbstractThe p53 transcription factor is a master regulator of cellular stress responses inhibited by repressors such as MDM2 and the phosphatase PPM1D. Activation of p53 with pharmacological inhibitors of its repressors is being tested in clinical trials for cancer therapy, but efficacy has been limited by poor induction of tumor cell death. We demonstrate that dual inhibition of MDM2 and PPM1D induces apoptosis in multiple cancer cell types via amplification of the p53 transcriptional program through the eIF2α-ATF4 pathway. PPM1D inhibition induces phosphorylation of eIF2α, ATF4 accumulation, and ATF4-dependent enhancement of p53-dependent transactivation upon MDM2 inhibition. Dual inhibition of p53 repressors depletes heme and induces HRI-dependent eIF2α phosphorylation. Pharmacological induction of eIF2α phosphorylation synergizes with MDM2 inhibition to induce cell death and halt tumor growth in mice. These results demonstrate that PPM1D inhibits both the p53 network and the integrated stress response controlled by eIF2α-ATF4, with clear therapeutic implications.