bluuebunny/crossref_metadata_2025_split huggingface dataset:
EEG complexity correlates with residual consciousness level of disorders of consciousness
Authors: Liu Yangfeng , Zeng Wentao , Pan Na , Xia Xiaoyu , Huang Yonghua , He Jianghong 
Published: October 2022

Abstract
Background and objective
Electroencephalography (EEG) and neuroimaging measurements have been highly encouraged to be applied in clinics of disorders of consciousness (DOC) to improve consciousness detection. We tested the relationships between neural complexity measured on EEG and residual consciousness levels in DOC patients.
Methods
Resting-state EEG was recorded from twenty-five patients with DOC. Lempel–Ziv complexity (LZC) and permutation Lempel–Ziv complexity (PLZC) were measured on the EEG, and their relationships were analyzed with the consciousness levels of the patients.
Results
PLZC and LZC values significantly distinguished patients with a minimally conscious state (MCS), vegetative state/unresponsive wakefulness syndrome (VS/UWS), and healthy controls. PLZC was significantly correlated with the Coma Recovery Scale-Revised (CRS-R) scores of DOC patients in the global brain, particularly in the anterior and posterior brain regions. Patients with higher CRS-R scores showed higher PLZC values. The significant difference in PLZC values between MCS and VS/UWS was mainly located in the anterior and posterior brain regions.
Conclusion
Neural complexity measured on EEG correlates with residual consciousness levels of DOC patients. PLZC showed higher sensitivity than LZC in the classification of consciousness levels.
Association of strontium exposure with liver function: A cross-sectional study from a mining area in Hunan, China
Authors: Feng Shuidong , Chen Limou , Tang Yan , Shen MinXue , Chen Xiang , Yang Fei 
Published: October 2022

Abstract
The relationship between exposure to a single heavy metal and liver function has been reported. However, the effect of strontium exposure on liver function has not been examined. A cross-sectional study involving 1,021 residents from a mining area in Hunan Province, China, was conducted to explore the single and combined effects of strontium exposure on liver function. Liver function was determined by detecting the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (TBIL) in the serum. The plasma concentrations of strontium (Sr), lead (Pb), cadmium (Cd), manganese (Mn), Zinc (Zn), and copper (Cu) in residents were measured using inductively coupled plasma-mass spectrometry (ICP-MS). The sociodemographic characteristics, lifestyle factors, and history of disease were assessed by questionnaire. Then the association between plasma Sr and liver function was analyzed by multiple linear regression and BKMR.
A positive correlation was found between Sr and ALT and Sr and AST (ALT: β = 14.86, 95% CI: 8.23, 21.50, P < 0.05 and AST: β = 9.67, 95%CI: 3.54, 15.80, P < 0.05) by multiple linear regression model. According to the BKMR, Sr and Pb and Sr and Cu had a synergistic effect on liver function. A single exposure or combined exposure to Sr are associated with liver function, which is influenced by age and gender. Sr and Pb and Sr and Cu have a synergistic effect on liver function. We reveal that Sr was an independent risk factor for ALT and AST based on the results of BKMR and GAMS.
WITHDRAWN: A comprehensive quality evaluation method of different medicinal parts of Physalis Calyx seu Fructus by fingerprints, chemometrics, antioxidant activity, network pharmacology, and molecular docking
Authors: Liu Meiqi , Liu Guoqiang , Ma Zicheng , Gao Jie , Liu Yi , Sun Lili , Ren Xiaoliang 
Published: October 2022

Abstract
Physalis Calyx seu Fructus (PCF) is one herb with the function of clearing heat and detoxify, benefiting pharynx and reducing phlegm, widely used in health care and tea drinking in China. However, the storage period of fruit and calyx was short and the quality was uneven. It is very important to further develop other parts with long storage period and obvious effect of medicine in PCF. Firstly, the fingerprint of differernt parts of PCF was developed by High-performance Liquid Chromatography (HPLC). The chemical markers were screened out by a variety of chemometric analyses. It was found that the calyxes of PCF could self-cluster among fruits, roots, stems, and leaves. It was found that the significant active components of PCF were mainly in persistent calyxes, and flavonoids were mainly in persistent calyxes and leaves. Moreover, the extraction of persistent calyxes had the strongest scavenging ability of DPPH and ABTS. Finally, the important chemical markers were verified by network pharmacological analysis and molecular docking. It provides a reference for clinical application of PCF, and the obtained chemical markers also provide a scientific reference for quality evaluation.
Beauveria bassiana interacts with gut and hemocytes to manipulate Aedes aegypti immunity
Authors: Bitencourt Ricardo Oliveira Barbosa , Corrêa Thaís Almeida , Reis-Mallet Jacenir , Santos Huarrison Azevedo , Lowenberger Carl , Moreira Haika Victória Sales , Gôlo Patrícia Silva , PinheiroBittencourt Vânia Rita Elias , Angelo Isabele Costa 
Published: October 2022

Abstract
Background: Mosquito-borne diseases affect millions of people. Chemical insecticides are currently employed against mosquitoes. However, many cases of insecticide resistance have been reported. Entomopathogenic fungi (EPF) have demonstrated potential as a bioinsecticide. Here, we assessed the invasion of the EPF Beauveria bassiana into Aedes aegyptilarvae and changes in the activity of phenoloxidase (PO) as a proxy for the general activation of the insect innate immune system. In addition, other cellular and humoral responses were evaluated.
Methods: Larvae were exposed to blastospores or conidia of B. bassiana CG 206. After 24 and 48 hours, scanning electron microscopy (SEM) was conducted on the larvae. The hemolymph was collected to determine changes in total hemocyte concentration (THC), the dynamics of hemocytes, and to observe hemocyte-fungus interactions. In addition, the larvae were macerated to assess the activity of PO using L-DOPA conversion, and the expression of antimicrobial peptides (AMPs) was measured using quantitative Real-Time PCR.
Results: Propagules invaded mosquitoes through the midgut, and blastopores were detected inside the hemocoel. Both propagules decreased the THC regardless of the time. By 24 h after exposure to conidia the percentage of granulocytes and oenocytoids increased while the prohemocytes decreased. By 48 h, the oenocytoid percentage increased significantly (P<0.05) in larvae exposed to blastospores; however, the other hemocyte types did not change significantly. Regardless of the time, SEM revealed hemocytes adhering to, and nodulating, blastospores. For the larvae exposed to conidia, these interactions were observed only at 48 h. Irrespective of the propagule, the PO activity increased only at 48 h. At 24 h, cathepsin B was upregulated by infection with conidia, whereas both propagules resulted in a downregulation of cecropin and defensin A. At 48 h, blastospores and conidia increased the expression of defensin A suggesting this may be an essential AMP against EPF.
Conclusion: By 24 h, B. bassiana CG 206 occluded the midgut, reduced THC, did not stimulate PO activity, and downregulated AMP expression in larvae, all of which allowed the fungus to impair the larvae to facilitate infection. Our data reports a complex interplay between Ae. aegypti larvae and B. bassianaCG 206 demonstrating how this fungus can infect, affect, and kill Ae. aegypti larvae.
Economic Feasibility Assessment of Microgrids with Renewable Energy Sources in Peruvian Rural Areas
Authors: Quispe Juan Carlos , Obispo Angel E. , Alcántara Francisco Javier 
Published: October 2022

Abstract
Electrification of Peru's rural areas is an issue of vital importance for economic growth. However, these areas still have poor quality electricity service or operate in a stand-alone mode with high cost of energy. To address this problem, one of the most promising strategies proposes the use of renewable energy technologies through the implementation of microgrids. In this context, this research develops the analysis of 37 cases of rural villages throughout Peru in order to obtain the optimal microgrid design and the most feasible areas for its implementation, considering the associated costs, geographic location, and load characteristics. For this purpose, an optimization process is carried out using Homer Pro software with the aim of sizing the microgrid with the minimum net present cost and cost of energy. Then, an iterative process is developed in Matlab software to map cost values, renewable contribution, emissions, the energy charge and the annual savings in the utility bill. This analysis considers five scenarios base on a grid-connected microgrid (with sensitivity values of grid sellback price) and an off-grid microgrid system. The results show the geographic distribution of all the annual utility saving bill. For the grid-connected microgrid condition, it presents a profit in the range of $107.08 to $368.2 compared to loads connected to the grid; while, for the off-grid microgrid condition, it presents a profit in the range of $1269 to $4976 in comparison with loads connected to a diesel generator.
BG-SDN: A Big Graph Framework for Topology Modeling and Traffic Analysis in Large-Scale SDN
Authors: Samaan Sama Salam , Jeiad Hassan Awheed 
Published: October 2022

Abstract
This paper presented a new method of modeling a Software Defined Networking (SDN) network as a graph and importing traffic data into the created graph using graph techniques to speed up the computations required in traffic analysis and management. For this purpose, a specialized application named TMTA (Topology Modeling and Traffic Analysis) is created to model the SDN network topology as a graph and feed the created graph with traffic data. To achieve high performance, the TMTA application is integrated with the Neo4j graph database utilizing its ability to store and process big graphs consisting of massive amounts of highly interconnected data in a scalable and reliable manner. For performance evaluation, various sizes of network topologies ranging from 41 to 62,586 devices are modeled using the TMTA application and stored in Neo4j. Evaluation results show that the proposed big graph framework can handle large-scale topologies effectively and perform traffic analysis tasks, i.e., calculating the control score of each device in the network and finding the shortest path between devices in a very reasonable time.
Research on the Health Assessment Method of Bronze Artifacts Excavated from Archaeological Sites
Authors: Li Juan , Li Li , Xie Zhenbin , Xiang Jiankai , Zhao Xichen , Xiao Qing , Ling Xue 
Published: October 2022

Abstract
As one of the common physical materials in Chinese archaeological excavations, ancient bronzes are important bases for studying the development of Chinese bronze culture, which is of great significance for exploring the development law of ancient human culture and reconstructing ancient human society. However, the ancient bronzes unearthed by archaeological excavations have been corroded to varying degrees under the dual influence of the soil burial environment and the sudden change of the above-ground environment, which has led to the different health status of the cultural relics. An adequate scientific evaluation of these bronzes is needed to inform how they should be extracted, moved and transported, as well as how subsequently they should be restored. Based on the analysis and research of relevant industry standards and the disease characteristics of bronzes to determine the risk factors affecting the health status of unearthed cultural relics, and then determines the main content of the health assessment of bronzes. By studying methods to effectively characterize the health status of bronzes and combining laboratory research to form a systematic method for in situ nondestructive analysis of bronzes. Through the systematic analysis of the detection results of the evaluation indicators to establish an analysis model for the health evaluation of bronzes. Finally, this paper achieves a scientific and effective evaluation of the health status of bronzes unearthed from archaeological sites. This enabled the feasibility of the extraction methods to be evaluated using the excavated Sanxingdui bronzes as samples.
Modified Diffusive Epidemic Process on the Apollonian Network
Authors: Alencar D. S. M. Alencar , Filho A. Macedo-Filho , Alves T. F. A. Alves , Alves G. A. Alves , Ferreira R. S. Ferreira , Lima F. W. S. Lima 
Published: October 2022

Abstract
We present an analysis of an epidemic spreading process on the Apollonian network that can describe an epidemic spreading in a non-sedentary population. We studied the modified diffusive epidemic process using the Monte Carlo method by computational analysis. Our model may be helpful for modeling systems closer to reality consisting of two classes of individuals: susceptible (A) and infected (B). The individuals can diffuse in a network according to constant diffusion rates DA and DB, for the classes A and B, respectively, and obeying three diffusive regimes, i.e., 𝐷𝐴 < 𝐷𝐵, 𝐷𝐴 = 𝐷𝐵 and 𝐷𝐴 > 𝐷𝐵. Into the same site i, the reaction occurs according to the dynamical rule based on Gillespie's algorithm. Finite-size scaling analysis has shown that our model exhibit continuous phase transition to an absorbing state with a set of critical exponents given by 𝛽∕𝜈 = 0.66(1), 1∕𝜈 = 0.46(2), and 𝛾′∕𝜈 = −0.24(2) familiar to every investigated regime. In summary, the continuous phase transition, characterized by this set of critical exponents, does not have the same exponents of the Mean-Field universality class in both regular lattices and complex networks.
Muscle hypertrophy and neuroplasticity in the small bowel in Short Bowel Syndrome
Authors: Khasanov Rasul , Svoboda Daniel , Tapia-Laliena María Ángeles , Kohl Martina , Maas-Omlor Silke , Hagl Cornelia Irene , Wessel Lucas M. , Schäfer Karl-Herbert 
Published: October 2022

Abstract
Short bowel syndrome (SBS) is a severe, life-threatening condition and one of the leading causes of intestinal failure in children. Here we were interested in changes in muscle layers and especially in the myenteric plexus of the enteric nervous system (ENS) of the small bowel in the context of intestinal adaptation. Twelve rats underwent a massive resection of the small intestine to induce an SBS. Sham laparotomy without small bowel transection was performed in 10 rats. Two weeks after surgery, the remaining jejunum and ileum were harvested and studied. Samples of human small bowel were obtained from patients who underwent resection of small bowel segments due to a medical indication. Morphological changes in the muscle layers and the expression of nestin, a marker for neuronal plasticity, were studied. Following a SBS, muscle tissue increases significantly in both parts of the small bowel, jejunum, and ileum. The leading pathophysiological mechanism of these changes is hypertrophy. Additionally, we observed an increased nestin expression in the myenteric plexus in the remaining bowel of SBS. Our human data also showed that in patients with SBS, the proportion of stem cells in the myenteric plexus have risen by more than two times. Our findings suggest that the ENS is tightly connected with changes in intestinal muscle layers and is critically involved in the intestinal adaptation process to SBS.
Molecular Aggregates Associated THz Coherent Vibrations Contribute to Enhancements of Emission Efficiencies
Authors: Wei Yu-Chen , Chen Bo-Han , Ye Ren-Siang , Huang Hsing-Wei , Su Jia-Xuan , Chen Kai , Hsu Liang-Yan , Chi Yun , Lu Chih-Hsuan , Yang Shang-Da , Chou Pi-Tai 
Published: October 2022

Abstract
The control of excited-state vibrational and electronic energy flows in molecular solids has a considerable impact on the performance of optoelectronic devices. In this study, we applied a novel ultrafast pump-probe system with 3.2 fs resolution to demonstrate that the aggregated Pt(II) complex 4H, an efficient near-infrared emitter, exhibits prominent single-mode vibrational coherence (VC) with a frequency of 32 cm−1 (~ 0.96 THz) in the excited state. This single-mode VC is associated with the collective out-of-plane motions induced by intermolecular metal-metal-to-ligand charge transfer transitions, which occur through ultrafast intersystem crossings with lifetimes of 150 fs. Similar single-mode VC characteristics were observed in analogues of 4H and other Pt(II) complexes with intense NIR emission. The conservation of single-mode VC enables excited-state deactivation to proceed along low-frequency coordinates, which contributes to the suppression of nonradiative decay rates and causes highly intense near-infrared emission in aggregated Pt(II) complexes. These novel results highlight the importance of VC in understanding nonradiative processes, elucidating the foundations of VC in molecular solid, which serve as a benchmark for evolving the device performance.
Central Obesity and Associated Factors Among Adult Patients Attending Public Health Facilities in Adama Town, Oromia Region, Ethiopia
Authors: Getahun Mihret Shawel , Deybasso Haji Aman , Komicha Meyrema Abdo , Gurara Abinet Menon 
Published: October 2022

Abstract
Background
Central obesity is excessive accumulation of fat around the abdomen which is associated risk of coronary heart and cerebrovascular diseases. This study determined the magnitude of central obesity among adult patients using the waist-to-hip ratio which has a superior capacity to measure the risk of developing non-communicable diseases compared to the body mass index used in previous studies in Ethiopia.
Methods
Institutional-based cross-sectional study was conducted among a sample of 516 adults from April 1 to May 30, 2022. A systematic random sampling technique was used to select the study participants. Data were collected by using interviewer-administered structured questionnaires and anthropometric measurements. The data were entered into EPI INFO version 7 and analyzed by Statistical Software for Social Science Version 25. The associations between independent and dependent variables were checked using bivariate and multivariate logistic regression analyses. Adjusted odds ratio and 95% confidence interval were used to measure of strengths of the association. Statistical significance was declared at a P-value of less than 0.05.
Results
The magnitude of central obesity in this study was 40% (51.2% and 27.4% among females and males respectively (95% CI: 36–44%). Being a female (AOR = 9.5, 95% CI: 5.22–17.9), age range 35–44 (AOR = 7, 95% CI: 2.9–16.7), 45–64 years (AOR = 10.1, 95% CI:4.0- 15.2), married (AOR = 2.5, 95% CI: 1.3–4.7), high monthly income (AOR = 3.3, 95% CI: 1.5–7.3), high consumption of milk and milk products (AOR = 0.3 ,95% CI: 0.1–0.6), family history of obesity (AOR = 1.8, 95% CI: 1.1–3.2) were significantly associated with central obesity among the study participants.
Conclusion
The magnitude of central obesity was higher in the study area. Sex, age, marital status, monthly income, consumption of milk and milk products, and family history of obesity were independent determinants of central obesity.
Resilience to substance use disorder following childhood maltreatment: association with peripheral biomarkers of endocannabinoid function and neural indices of emotion regulation.
Authors: Perini Irene , Mayo Leah , Capusan Andrea J. , Paul Elisabeth , Kämpe Robin , Gauffin Emelie , Mazurka Raegan , Stensson Niclas , Asratian Anna , Hamilton J. Paul , Kastbom Åsa , Gustafsson Per , Heilig Markus , Yngve Adam 
Published: October 2022

Abstract
Childhood maltreatment (CM) is a risk factor for substance use disorders (SUD) in adulthood. Understanding the mechanisms by which people are susceptible or resilient to developing SUD after exposure to CM is important for improving intervention. This case-control study investigated the impact of prospectively assessed CM on biomarkers of endocannabinoid function and emotion regulation in relation to the susceptibility or resilience to developing SUD. Four groups were defined across the dimensions of CM and lifetime SUD (n = 101 in total). After screening, participants completed two experimental sessions on separate days, aimed at assessing the behavioral, physiological, and neural mechanisms involved in emotion regulation. In the first session, participants engaged in tasks assessing biochemical (i.e., cortisol, endocannabinoids), behavioral, and psychophysiological indices of stress and affective reactivity. During the second session, the behavioral and brain mechanisms associated with emotion regulation and negative affect were investigated using magnetic resonance imaging. CM exposed adults who did not develop SUD, operationally defined as resilient to developing SUD, had higher peripheral levels of the endocannabinoid anandamide at baseline and during stress exposure, compared to controls. Similarly, this group had increased activity in salience and emotion regulation regions in task-based measures of emotion regulation compared to controls, and CM exposed adults with lifetime SUD. At rest, the resilient group also showed significantly greater negative connectivity between ventromedial prefrontal cortex and anterior insula compared to controls and CM exposed adults with lifetime SUD. Collectively, these peripheral and central findings point to mechanisms of potential resilience to developing SUD after documented CM exposure.
Towards a generalized Regev's cryptosystem and its related signing cryptosystem: An implementation for hashes and simple ASCII texts in Python
Authors: BARJ Sara 
Published: October 2022

Abstract
Quantum computing makes most of nowadays protocols breakable. Fortunately, this technology is still too expensive to be used by anybody.
The cryptosystems relying on the LWE problem are still an excellent choice to prepare for the democratization of quantum computing.
The motivation of this work is to implement a post-quantum complete and complex asymmetric cryptosystem using the learning with error (LWE) problem. In fact, it is impossible or hard to find a cryptosystem in Python in the literature like the implemented one.
As a contribution, this work proposes an implementation of a generalized Regev's Cryptosystem and its related signature and verification functions for achieving the quantum-safety property.\\ It also tests the validity of a list of primes for specified values.
Finally, this work completes the cryptosystem with the signing and verification algorithms. These algorithms are news for the scientific community. Errors and omissions excepted.
These implementations are based on hard problems related to lattices