bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influencing Factors And Prediction Methods Of Radiotherapy And Chemotherapy In Patients With Lung Cancer Based On Logistic Regression Analysis
Authors: Liu Yuxia , Xu Chang , Xing Chengyan , Chen Mingwei 
Published: February 2022

Abstract
Background: Logistic regression analysis has widespread applications in clinical disease diagnosis, but it has not yet been applied to assess the acceptance of radiotherapy and chemotherapy in patients with lung cancer. A prediction model was established to investigate the influencing factors of radiotherapy and chemotherapy in lung cancer patientsMethods: A sample was admitted of lung cancer patients to Binzhou Medical University Hospital stays from January 2020 to June 2021. After investigating doctors, nurses, patients, managers and conducting expert demonstration, the questionnaire was formed. The questionnaire was filled out by the patient or the patient's family members. The factors in the questionnaire data of patients accepting and not accepting radiotherapy and chemotherapy were compared for monofactor analysis, and the significantly different single factor were analyzed by multifactor logistic regression analysis, explored the influencing factors of radiotherapy and chemotherapy in lung cancer patients established a predictive model and drew the receiver operating characteristic curve (ROC curve).Results: The factors of two groups had statistically significant differences or no statistically significant differences. After multifactor logistic regression analysis was conducted, own personality, self-care ability, disease course classification, own attitude towards disease treatment, and family attitude towards disease treatment were included in the influencing factors of radiotherapy and chemotherapy in patients with lung cancer. Then, a predictive model was established. The area under the ROC curve of the predicted model was 0.973, the 95% confidence interval was 0.952-0.995, the optimal critical value was 0.832, the sensitivity was 91.84%, the specificity was 89.09%, and the accuracy was 90.85%.Conclusions: Based on logistic regression analysis, the prediction model could predict the extent of accepting radiotherapy and chemotherapy in patients with lung cancer. Understanding the factors related to patients with lung cancer accepting radiotherapy and chemotherapy could provide useful information for the targeted and effective treatment by clinicians.
Molecular evidence indicates the existence of multiple lineages of Sperata in Indian Rivers
Authors: Yadav Prabhaker , Kumar Ajit , Yadav Neha , Bisht Mansi , Mital Anuja , Johnson Jeyaraj Antony , Hussain Syed Ainul , Gupta Sandeep 
Published: February 2022

Abstract
Understanding the population genetic structure and species boundaries in the complex river system has been challenging. The genus Sperata, a commercially important and widely distributed freshwater catfishes of India, belongs to Bagridae. The taxonomy of the Sperata genus is complex and still under revision. Recently, five valid species of Sperata were described from the Indian subcontinent. To determine the species boundaries and presence of taxonomic units within the Spereta, we analyzed the sequences of mitochondrial DNA (mtDNA) cytochrome c oxidase I (COI) and control region (CR) from Ganga, Gomti, Brahmaputra and Mahanadi river. The analysis of species delimitation using the COI gene indicated the presence of multiple taxonomic units among Sperata. Similarly, CR suggested the high haplotype diversity in S. lamarrii with a signature of demographic expansion in the Ganga river. In this study, we identified S. cf. lamarrii, a new lineage from the lower stretch of Ganga, another Sperata sp. from the Brahmaputra, Surma (Bangladesh) river, and from an unknown locality. It also highlighted that the Brahmaputra river also holds a highly diverse lineage that genetically qualifies the status of distinct species. Our finding suggests that multiple lineages of Sperata existed in the Indian River system; therefore, these should be considered a different management unit to protect contamination of natural stock. This study can be further used as a reference database for proper lineage identification within Sperata to formulate appropriate conservation and management plans.
Analysis of optical and thermal properties of 940-nm vertical-cavity surface-emitting lasers
Authors: Wang Congcong , Li Chong , Wang Zhiyong 
Published: February 2022

Abstract
We achieve 13.5mW optical output power, 48% power conversion efficiency, 1.17 W/A slope efficiency and 17kW/cm2 laser power density with top-surface-emitting 940 nm oxide-confined vertical-cavity surface-emitting laser (VCSEL). The physical mechanism of minimum threshold current generation in oxide-confined VCSEL has been thoroughly studied theoretically and experimentally. Further, we also succeeded in 90.8mW optical output power, 40% power conversion efficiency with 2×4 VCSEL arrays. We find an increase in output power and PCE of 2×2 VCSEL arrays as we increase the array spacing which we attribute primarily to increased heat dissipation and reduced thermal crosstalk between the emitters. Thermal properties in oxide-confined 2×2 VCSEL arrays were analyzed numerically and experimentally. The simulated results are in good agreement with the measurement. It is proved that theoretical simulation is very useful for the future device optimization.
Daphnetin Ameliorates Neuropathic Pain in CCI Rats by Interfering With Microglia P2X4 - P38 MAPK (Daphnetin Improves Neuropathic Pain)
Authors: Zhang Tianrui , Zhang Mingqian , Ou Wenjing , Cui Shuang , Liang Wulin , Jia Zhanhong , Xue Fan , Wu Yonghong , Huang Xiyan , Ge Dongyu , Zhang Shuofeng , Dong Ruijuan 
Published: February 2022

Abstract
Background: Neuropathic pain is a common chronic pain caused by a lesion or diseases of somatosensory nervous system, which has a significant impact on the quality of life. It has been found that its underling pathological mechanism is related to inflammation. Daphnetin is a natural product with a variety of biological activities such as anti-inflammatory and analgesic. It has been shown to be effective in the treatment of chronic inflammatory pain, but its underlying mechanisms are not completely understood. We aimed to evaluate the effect and regulatory mechanism of daphnetin on neuropathic pain.Methods: The experimental animals were divided into 8 groups: control group, model group, sham group, positive group (0.0375mg/kg), DAPH group (0.0625mg/kg), DAPL group (0.025mg/kg), P2X4 blocker group (1mg/kg) and P38 blocker group (5mg/kg). After constructing the subdural drug delivery system in rats, the neuropathic pain model was established by chronic constrictive injury (CCI), and the pain sensitivity was evaluated by measuring mechanical withdrawal threshold (MWT) and thermal withdrawal threshold (TWT). The protein expression of inflammatory factors and related pathways was measured by Western Blot. The activation of microglia and neurons and the expression of target protein in spinal dorsal horn were measured by immunofluorescence staining.Results: Compared with the sham group, MWT and TWT decreased significantly in model group, and the expression of IL-1 β, IL-6 and TNF-α increased. After intrathecal injection of daphnetin, the MWT and TWT of rats were significantly increased, and the protein expression of IL-1 β, IL-6 and TNF- α was significantly decreased compared with the model group. Compared with sham group, the expression of P2X4, IRF8, IRF5, BDNF, p-P38 / P38, p-JNK / JNK and p-ERK1/2 / ERK1/2 in model group increased significantly. After intrathecal injection of daphnetin, the expression of the above proteins was significantly down-regulated compared with model group. Compared with sham group, microglia and neurons in the spinal dorsal horn of model group were activated, and the expression of P2X4 and P38 in microglia increased. After intrathecal injection of daphnetin, compared with the model group, the activation of microglia and neurons in the spinal dorsal horn decreased significantly, and the expression of P2X4 and P38 in microglia decreased. Importantly, daphnetin could not improve neuropathic pain in CCI rats under the action of P2X4 and P38 blocker.Conclusion: daphnetin can alleviate neuropathic pain in CCI model rats by interfering with P2X4-P38 MAPK pathway of microglia, suggesting that daphnetin is a potential drug for the treatment of neuropathic pain.
Multi-locus genotype-based modeling reveals that rising temperatures can stabilize the flowering date of winter wheat
Authors: He Yong , Xiong Wei , Hu Pengcheng , Xu Yinlong , Hao Chenyang , DePauw Ron , Zheng Bangyou , Huang Daiqing , Hoogenboom Gerrit , Dixon Laura , Challinor Andy 
Published: February 2022

Abstract
Flowering-date stability is crucial for global adaptability of wheat to sustain a high grain yield within broad temperature ranges; however, the response mechanism of such stability to climate change remains unclear. Here, we developed a multi-locus genotype based (MLG-based) ecophysiological model to predict wheat-flowering date that allowed for the linkage of key photoperiod (Ppd) and vernalization (Vrn) genes to wheat flowering. The MLG-based model was then applied to reveal the responses of wheat-flowering-date stability to different allelic combinations under projected climatic conditions across the Northern China winter wheat Region. The results showed that the stability of the flowering date for wheat could be enhanced under projected RCP4.5 and RCP8.5 global warming scenarios with allelic combinations of major Vrn and Ppd genes. Our findings highlight the potential of introducing allelic combinations of the winter allele vrn-D1 and photoperiod-insensitive genes (Ppd-D1a) into currently-cultivated varieties in order to maintain a more stable flowering date, especially under future climate conditions.
Uncovering Potential Novel Biomarkers In Crohn's Disease Using Integrated Bioinformatics Analysis
Authors: Feng Jinggao 
Published: February 2022

Abstract
Background: Crohn's disease is a chronic nonspecific intestinal inflammatory disease with unknown etiology. This study aimed to predict potential novel biomarkers of Crohn's disease.Methods: Gene expression datasets of Crohn's disease and normal samples were downloaded from the Gene Expression Omnibus (GEO) database. First, differential gene expression analysis and weighted gene coexpression network analysis (WGCNA) were performed. Common genes (CGs) were obtained by the intersection of differentially expressed genes (DEGs) and optimal modal genes of WGCNA. Subsequently, a protein-protein interaction (PPI) network was established to screen hub genes and then establish a Crohn's disease risk prediction model based on hub genes. A receiver operating characteristic (ROC) curve, and area under the curve (AUC) were used to evaluate the prediction ability of the model. Finally, the mirTarBase database, starBase database, and TargetScan database were used to predict microRNAs (miRNAs) and transcription factors (TFs) that cause Crohn's disease.Results: A total of 74 DEGs were identified. WGCNA showed that the signature gene in the blue module was significantly associated with Crohn's disease (p=4e-6) and obtained 32 CGs. Five hub genes (CDH17, CSF1R, CXCL10, CXCL9, COL3A1) were identified and well predicted Crohn's disease risk (AUC=0.853). Meanwhile, in the miRNA-mRNA regulatory network and TF-mRNA regulatory network, we found that 3 miRNAs (hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p) and 2 TFs (TCF4, HINFP) regulate multiple CGs.Conclusions: Five genes (CDH17, CSF1R, CXCL10, CXCL9 and COL3A1), three miRNAs (hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p) and two TFs (TCF4, HINFP) may be involved in the pathogenesis of Crohn's disease.
Gaming strategies within a green supply chain considering consumers' concern about the greenness and conformance quality of products
Authors: yi yongxi , Yang Min , Fu Chunyan , Li Yuqiong 
Published: February 2022

Abstract
Improving the greenness and conformance quality of a product is two fundamental and intertwined considerations in today's supply chain decision-making. However, the related literature rarely considers conformance quality improvement of products in green supply chain management. This paper incorporates both into a framework to analyze the optimal strategies of a manufacturer responsible for conformance quality of product and greenness improvement and a retailer responsible for product marketing in a supply chain under four contracts: full cooperation, price-only contract, two-part tariff, and marketing cost-sharing. The analysis shows that full cooperation and two-part tariffs lead to the same and highest product quality, greenness, overall profit, and social welfare, but full cooperation is difficult to achieve in the supply chain. For the profit-maximizing manufacturer and retailer, the manufacturer most prefers two-part tariff contracts while the retailer prefers marketing cost-sharing because both achieve the highest profit in the preferred contract. Under the price-only contract, conformance quality of product and greenness are lowest, and profit levels for manufacturers and retailers are lowest. In all four cases, increased environment and quality awareness contribute to improved product greenness and conformance quality, leading to higher profits for the manufacturer and retailer and higher social welfare.
Chronic Intermittent Hypobaric Hypoxia Prevents contrast-Induced Acute Kidney Injury by Modulating the HIF-1α Signaling Pathway
Authors: Yin Kai-min , Ni Yan-hui , Cao Guang-yun , Zhang Jia-yuan , Yi Bao-jun , Pang Zi-hao , Ma Hui-jie , Zhang Li 
Published: February 2022

Abstract
The aim of this study was to explore the role of CIHH in preventing contrast-induced acute kidney injury (CI-AKI) in rats and its mechanism. Rats mean arterial pressure ,heart rate, blood creatinine and urea nitrogen levels were measured. The kidney tissue pathological changes, superoxide dismutase (SOD) activity, malondialdehyde (MDA)levels, HIF-1α、Bcl-2 19-kDa interacting protein3 (BNIP3)、caspase3and poly(ADP-ribose) polymerase (PARP) expression levels were testing. The results showed that CIHH pretreatment CI-AKI group mean arterial pressure、heart rate、blood creatinine and urea nitrogen levels were reduced, kidney tissue SOD activity was increased, MDA levels was reduced, HIF-1α、 BNIP3、caspase3 and PARP levels were increased than the CI-AKI group. This study indicates that CIHH pretreatment may have a protective effect on contrast-induced early kidney injury by activating the HIF-1α/BNIP3 signaling pathway to regulate mitochondrial autophagy and enhance cellular anti-apoptotic and renal antioxidant capacity, for the first time.
Exploring communication of the HIV/AIDS health policy change to test-and-treat and its effect on policy implementation in selected public health facilities in Lusaka district, Zambia
Authors: Simooya Constance , Silumbwe Adam , Halwindi Hikabasa , Zulu Joseph Mumba , Nzala Selestine 
Published: February 2022

Abstract
Background
The World Health Organisation has promoted a shift towards the test and treat strategy to accelerate elimination of HIV/AIDS. Zambia adopted this policy change in 2017. However, communication of this policy change and its effect on policy implementation has not been documented. This study sought to explore the communication of the HIV/AIDS test and treat health policy change and how this affects practice in selected public health facilities in Lusaka district.
Methods
A qualitative case study was employed with purposeful sampling of policy makers, partners, National AIDS Council managers and frontline health providers in selected tertiary, secondary and primary-level health facilities in Lusaka District of Zambia. In total, 22 key informant interviews and 3 focus group discussion were conducted. Thematic inductive – deductive approach coding and data analysis were performed using NVivo pro 12 software.
Results
The results revealed that to communicate test and treat policy change; government relied on print media such as newspapers, IEC materials and electronic media through radios and television. The official channels of communication and feedback mechanisms for test and treat HIV health policy change were not clearly stipulated in the health facilities for reference. This created a lapse in communication which resulted in policy misinterpretation and resistance from both implementers and clients. The HIV policy changes reshaped health systems negatively as infrastructure was altered to accommodate increased service demand workload for HIV services and operational hours for HCWs. Further, policy makers seemed to be unprepared for the policy changes.
Conclusion
Effective health policy change communication with clear channels and open feedback mechanisms is vital for successful policy change implementation as it enhances understanding and subsequently adoption of the policy. Further, there is a need to enhance collaboration amongst policy makers, partners, implementers and the public in developing and applying communication strategies that facilitate quick adoption of health policy changes.
Pharmacokinetic and metabolomic studies with a BIO 300 Oral Powder formulation in nonhuman primates
Authors: Li Yaoxiang , Girgis Michael , Jayatilake Meth , Serebrenik Artur A. , Cheema Amrita K , Kaytor Michael D. , Singh Vijay K. 
Published: February 2022

Abstract
BIO 300, a nanosuspension of genistein, is a radiation countermeasure being developed to treat hematopoietic acute radiation syndrome (H-ARS) and the delayed effects of acute radiation exposure (DEARE). Several studies have affirmed its safety and efficacy in alleviating the damaging effects of ionizing radiation. However, dose optimization of any drug has always been an important area of research because unnecessarily high drug doses may result in serious complications. In this study, we assessed the pharmacokinetics (PK) and metabolic profiles of two different doses of BIO 300 Oral Powder (100 mg/kg and 200 mg/kg) when administered orally to nonhuman primates (NHPs). While the Tmax values of both doses remained the same, the area under the curve at 48 h (AUC0−48) was tripled by doubling the dose. Additionally, we monitored serum samples for global metabolomic/lipidomic changes using high resolution mass spectrometry followed by functional pathway analysis prior to and at various time points up to 48 h post drug administration. Interestingly, the metabolomic profiles of sera from NHPs that received the lower dose demonstrated a transient perturbation in numerous metabolites between the 4 and 12 h time points. Eventually, the metabolite abundance reverted to near-normal by 48 h. These study results are consistent with our previous studies focused on the PK and metabolomic analysis for parenteral and oral suspension formulations of BIO 300. This study affirms that administration of a single dose of up to 200 mg/kg of BIO 300 Oral Powder conferred no metabolomic-mediated safety features, suggesting the drug can be safely used to combat radiation injury.
Udder, teat and milk vein morphology of Indian dromedary camel and its relationship with milkability traits
Authors: Kumar Manoj , Nehara Manju , Prakash ved , Pannu Urmila , Jyotsana Basanti 
Published: February 2022

Abstract
The economic viability of the camel in the current scenario can be ensured by improving its dairy potential. The study on the udder and teat characteristics of dromedary and its relationship with milk yield and milkability can be of great value in establishing camel as a dairy animal. The present study was conducted on 45 lactating she-camels of four Indian camel breeds viz. Bikaneri, Jaisalmeri,Kachchhi and Mewari stationed at ICAR-NRCC Bikaner, Rajasthan (India). Various udder and teat morphology, milk yield and milkability traits, factors affecting these traits and the relationship between these traits were studied in hand-milked Indian dromedary camel. The means ± S.E. of teat lengths of left fore, left rear, right fore and right rear teats were measured as 52.21 ± 1.66, 58.52 ± 2.11, 50.13 ± 1.74 and 54.37 ± 1.82 mm, respectively. The means ± S.E. of teat diameters for left fore, left rear, right fore and right rear teats were 42.44 ± 1.60, 46.01 ± 1.68, 39.29 ± 1.31 and 45.20 ± 1.56 mm, respectively. The means ± S.E for udder depth, udder length, udder height from the ground, milk vein diameter and milk vein length were observed as 25.44 ± 0.42, 37.29 ± 0.80, 114.80 ± 0.80, 2.02 ± 0.08 and 88.70 ± 0.96 cm, respectively. The effect of age at calving was significant (p≤0.05). Positive and highly significant (p≤0.01) correlations of milk yield were observed with the majority of udder and teat characteristics, milking time, milk flow rate while a negative correlation was found with udder height and milk let down time. It can be concluded that udder characteristics are influenced by various genetic and non-genetic factors and its relationship with milk yield and milkability can be used for selection and dairy management purposes.
Parental knowledge on prevention of caries in children and the efficacy of a leaflet intervention.
Authors: Elkarmi Rawan , AlJafari Ahmad , Haddad Sarah , AlSoud Dina 
Published: February 2022

Abstract
BackgroundParental education on child oral health has an important role in caries prevention. Leaflets are a means of delivering educational messages. The study aims to evaluate the efficacy of leaflets in improving parental knowledge on prevention of caries in children. MethodsA cross-sectional study. Parents attending with their children to a pediatric clinic at a large hospital were asked to complete a questionnaire that noted their sociodemographic characteristics, oral hygiene practices, and knowledge on prevention of caries in children. Their knowledge on caries prevention in children was given a score out of 20. After reading an educational leaflet covering the main aspects of caries prevention, a follow up phone interview was conducted one month later to evaluate any improvement in parental knowledge. ANOVA and McNemar’s tests were used for statistical analysis. Results391 parents participated in the study. The average knowledge score pre-intervention was 6.4 out of 20. There was no significant association between any of the sociodemographic variables and pre-intervention knowledge scores. 10.8% of parents were regular dental attenders. Around 12% of parents were aware of the age of the child at the first dental visit and the correct age to start toothbrushing; 20.5% knew about fluoride varnish; 7.2% understood that sugar containing snacks should be consumed at once; and less than 50% believed that regular dental visits prevent caries. After reading the leaflet there was a statistically significant improvement in almost all variables evaluating parents’ knowledge on caries prevention in children. ConclusionKnowledge on prevention of caries in children among this sample of parents is very poor. Leaflets were successful in improving parental knowledge. There is a need to implement such leaflets in healthcare centers and hospitals and to further evaluate their efficacy by comparison with other means.