bluuebunny/crossref_metadata_2025_split huggingface dataset:
Near-infrared spectroscopy as a green technology to monitor coffee roasting
Authors: Wójcicki Krzysztof 
Published: September 2022

Wet chemistry methods are traditionally used to evaluate the quality of a coffee beverage and its chemical characteristics. These old methods need to be replaced with more rapid, objective, and simple analytical methods for routine analysis. Near-infrared spectroscopy is an increasingly popular technique for nondestructive quality evaluation called a green technology.
Our study aimed to apply near-infrared spectroscopy to evaluate the quality of coffee samples of different origin (Brazil, Guatemala, Peru, and Kongo). Particularly, we analyzed the roasting time and its effect on the quality of coffee. The colorimetric method determined a relation between the coffee color and the time of roasting. Partial least squares regression analysis assessed a possibility of predicting the roasting conditions from the near-infrared spectra.
The regression results confirmed the possibility of applying near-infrared spectra to estimate the roasting conditions. The correlation between the spectra and the roasting time had R2 values of 0.96 and 0.95 for calibration and validation, respectively. The root mean square errors of prediction were low – 0.92 and 1.05 for calibration and validation, respectively. We also found a linear relation between the spectra and the roasting power. The quality of the models differed depending on the coffee origin and sub-region. All the coffee samples showed a good correlation between the spectra and the brightness (L* parameter), with R2 values of 0.96 and 0.95 for the calibration and validation curves, respectively.
According to the results, near-infrared spectroscopy can be used together with the chemometric analysis as a green technology to assess the quality of coffee.
Fetal Encephalomalacia Secondary to Acute Maternal Blood Loss: A Case Study
Authors: Manzar Shabih 
Published: September 2022

Background:
Fetal neurons are sensitive to ischemia which could happen secondary to acute maternal blood loss. The damage to the fetal brain with loss of brain
neurons in early gestation leads to encephalomalacia. We describe here a case report of fetal encephalomalacia secondary to acute maternal blood
loss.

Case Presentation:
A 23-year-old gravida 3, para 2 woman sustained a forearm laceration at 18 weeks of gestation. Her hemoglobin dropped to 7.9 mg/dL. A surgical
laceration repair was completed, and she was transfused with blood. At the OB visit the following week, her fetal US showed abnormal brain,
evident by the increased size of the lateral ventricles. A follow-up MRI at 30 weeks of gestation confirmed fetal encephalomalacia. A complete
investigation, including free cell maternal DNA for chromosomal anomalies, TORCH infection, and Covid PCR, all were negative.

Conclusion:
We concluded from the case that any history of significant acute maternal blood loss that required blood transfusion should necessitate a fetal
ultrasound to look for fetal well-being, especially for any brain structural changes in the developing brain.
Biomarkers in Hypertension and Hypertension-related Disorders
Authors: de Carvalho Ribeiro Patrícia , Oliveira Lucas Felipe , Filho Daniel Mendes , Parreira Ricardo Cambraia , Vieira Mariana Sousa , Marques Bruno Lemes , da Madeira Freitas Elis Marra , Silva Walison N. , Santiago Helton da Costa , Birbrair Alexander , Ulrich Henning , da Silva Valdo José Dias , Resende Rodrigo R. 
Published: September 2022

Abstract:
Systemic arterial hypertension (SAH) is a major risk factor for several secondary
diseases, especially cardiovascular and renal conditions. SAH has a high prevalence
worldwide, and its precise and early recognition is important to prevent the development
of secondary outcomes. In this field, the study of biomarkers represents an important
approach to diagnosing and predicting the disease and its associated conditions. The
use of biomarkers in hypertension and hypertension-related disorders, such as ischemic
stroke, intracerebral hemorrhage, transient ischemic attack, acute myocardial infarction,
angina pectoris and chronic kidney disease, are discussed in this review. Establishing a
potential pool of biomarkers may contribute to a non-invasive and improved approach
for their diagnosis, prognosis, risk assessment, therapy management and pharmacological
responses to a therapeutic intervention to improve patients' quality of life and prevent unfavorable
outcomes.
Significant Role of Long Non-coding RNAs in Parkinson’s Disease
Authors: Na Chen , Wen-Wen Chen , Li Wang , Ao-Jia Zhou , Ting Wang 
Published: September 2022

Background:
Parkinson's disease (PD) is the second most common neurodegenerative disease in the
world, with clinical manifestations of resting tremor, akinesia (or bradykinesia), rigidity, and postural instability. However, the molecular pathogenesis of PD is still unclear, and its effective treatments are limited. Substantial evidence demonstrates that long non-coding RNAs (lncRNAs) have important functions in various human diseases, such as cancer, cardiovascular disease, and neurodegenerative diseases. Therefore, the main purpose of this study is to review the role of lncRNAs in the pathogenesis of PD.

Methods:
The role of lncRNAs in the pathogenesis of PD is summarized by reviewing Pubmed.

Result:
Thirty different lncRNAs are aberrantly expressed in PD and promote or inhibit PD by mediating
ubiquitin-proteasome system, autophagy-lysosomal pathway, dopamine (DA) neuronal apoptosis, mitochondrial function, oxidative stress, and neuroinflammation.

Conclusion:
In this direction, lncRNA may contribute to the treatment of PD as a diagnostic and therapeutic
target for PD.
Metabolic Pathways Regulating Colorectal Cancer: A Potential Therapeutic
Approach
Authors: Zafari Nima , Velayati Mahla , Damavandi Sedigheh , Pourali Ghazaleh , Mobarhan Majid Ghayour , Nassiri Mohammadreza , Hassanian Seyed Mahdi , Khazaei Majid , Ferns Gordon A. , Avan Amir 
Published: September 2022

Abstract:
Colorectal cancer (CRC) is one of the most prevalent cancers globally. Despite recent progress in
identifying etiologies and molecular genetics as well as new therapeutic approaches, the clinical outcome of
current CRC therapies remains poor. This fact highlights the importance of further understanding underlying
mechanisms involved in colorectal tumor initiation and progression. Abnormal metabolic alterations offer an
evolutional advantage for CRC tumor cells and enhance their aggressive phenotype. Therefore, dysregulation of
cellular metabolism is intricately associated with colorectal tumorigenesis. This review summarizes recent findings
regarding the CRC-related changes in cellular metabolic pathways such as glycolysis, tricarboxylic acid
cycle, fatty acid oxidation, and mitochondrial metabolism. We describe the oncogenic signaling pathways associated
with metabolic dysregulation during malignant transformation and tumor progression. Given the crucial
role of metabolic pathway alterations in the pathogenesis of CRC, we provide an overview of novel pharmacological
strategies for the treatment of CRC by targeting metabolic and signaling pathways.
Gastrointestinal System: COVID-19 and Potential Mechanisms Associated
with Coagulopathy
Authors: Danese Silvio , Furfaro Federica , Gabbiadini Roberto , D’Amico Ferdinando , Zilli Alessandra , Dal Buono Arianna , Allocca Mariangela , Fiorino Gionata 
Published: September 2022

Abstract:
SARS-CoV-2 is a novel coronavirus that expanded worldwide, generating a pandemic of acute respiratory syndrome called “coronavirus disease 2019” (COVID-19), which resulted in a global health crisis. The spectrum of COVID-19 manifestations ranges from none or mild symp-toms to severe respiratory failure associated with systemic manifestations, mostly gastrointestinal symptoms. Hypercoagulability is an important feature of COVID-19 disease, which can potentially influence patients’ prognosis. Therefore, gastroenterologists should focus on subjects with concomi-tant hypercoagulable gastrointestinal disorders as they may display a higher risk of thrombotic complications during SARS-CoV-2 infection. The aim of this review is to summarize the available evidence regarding the interplay of the prothrombotic pathogenetic mechanisms of both COVID-19 and hypercoagulable digestive diseases and the possible clinical implications. We summarized the potential interplay of prothrombotic mechanisms of both COVID-19 and hypercoagulable digestive diseases in the graphical abstract.
Role of Innate Immune and Inflammatory Responses in the
Development of Secondary Diabetic Complications
Authors: Plowman Trevor J. , Shah Mujtaba H. , Fernandez Emely , Christensen Hannah , Aiges Myia , Ramana Kota V. 
Published: September 2022

Abstract:
Increased hyperglycemia due to uncontrolled diabetes is the major cause of
secondary diabetic complications such as retinopathy, neuropathy, nephropathy, and
cardiovascular diseases. Although it is well known that increased oxidative stress,
activation of the polyol pathway, protein kinase C and increased generation of advanced
glycation end products could contribute to the development of diabetic complications,
recent studies implicated the role of innate immunity and its related inflammatory
responses in the pathophysiology of secondary diabetic complications. Increased activation
of oxidative stress signaling could regulate NLRP3 inflammasome-mediated
innate immune responses as well as NF-κB signalosome-mediated pro-inflammatory
responses. This review article focused on the pathogenic role of innate immune and
inflammatory responses in the progression of hyperglycemia-induced secondary diabetic
complications. Specifically, we discussed in depth how deregulated innate immune
and inflammatory responses could lead to an aggravated release of cytokines,
chemokines, and growth factors resulting in the development of various secondary
complications of diabetes.
Protein Arginine Methyltransferases 5 (PRMT5) affect Multiple Stages of
Autophagy and Modulate Autophagy-related Genes in Controlling Breast
Cancer Tumorigenesis
Authors: Ling Rui , Kong Jing , Wang Zhe , Zhang Yong , Wang Ting 
Published: September 2022

Background:
Autophagy disorders are linked to human cancer, and the details of their
mechanisms remain unclear.

Objective:
To investigate the regulatory role of PRMT5 in the autophagy of breast cancer cells.

Methods:
Human breast adenocarcinoma cell lines (MDA-MB-231, MCF7) were cultured. Plasmids
of overexpression and down-regulation of PRMT5 were transfected into MDA-MB-231 and MCF7
cells. The MTT assay was used to determine the proliferation of MDA-MB-231 and MCF7 cells. A
western blotting assay was used to verify the expression of autophagy-associated molecules. Immunofluorescence
was applied to observe the expression of GFP-LC3.

Results:
The expression of PRMT5 decreased the sensitivity to rapamycin and nutrient deprivation.
PRMT5 acts as an oncogene to promote cell proliferation and influences migration and stamness.
PRMT5 expression elevated the autophagic activity initiated by EBSS and Rapamycin. PRMT5 was
necessary and sufficient to enhance stress-induced autophagy. PRMT5 could improve several autophagy-
related gene expressions. Atg5 expression could be regulated by activating the PRMT5 and
PDCD4 molecules. The PRMT5 molecule could mediate the regulation of ULK1 expression.

Conclusions:
PRMT5 influenced multiple stages of autophagy in controlling autophagy and tumorigenesis.
Autophagy-related PRMT5 might be a respected target for therapeutic interventions in cancers.
This study would provide new ideas for treating and selecting breast cancer targets.
Effectiveness and Safety of Immunosuppressive Drug Therapy for Neuromyelitis
Optica Spectrum Disorders: An Overview of Meta-Analyses and
Systematic Reviews
Authors: Luo Yuan , Deng Yuqian , Ran Haiye , Yu Lei , Ma Caili , Zhao Liping , Li Yunchen 
Published: September 2022

Objective:
This study aims to provide an overview of meta-analyses and systematic reviews
on the effectiveness and safety of immunosuppressive drug therapy for neuromyelitis optica spectrum
disorders (NMOSD) by evaluating the methodological quality and reporting quality of reviews.

Methods:
The Chinese National Knowledge Infrastructure (CNKI), WanFang Data, China Science and
Technology Journal Database, Web of Science, the Cochrane Library, PubMed, and Embase databases
were searched to collect systematic reviews or meta-analyses on the effectiveness and safety of immunosuppressive
therapy for NMOSD from inception to December 2, 2021. Two researchers independently
screened reviews and extracted data. Any differences in the procession of review assessment
between the two researchers were re-evaluated, and the disagreement was resolved by discussion
with other researchers. The following data were extracted: author, year of publication, the country
where the study was conducted, study type, the number of included studies, sample size, risk bias
tools, medication of immunosuppressive therapy, and main outcomes. Then, the AMSTAR-2, which is
a critical appraisal tool for systematic reviews (2nd edition), and Grades of Recommendation, Assessment,
Development and Evaluation (GRADE) were used to evaluate the methodological quality and
reporting quality of evidence. A comprehensive analysis was conducted on the outcomes for all included
reviews.

Results:
A total of 15 reviews were included. Of the included reviews, 3 were systematic reviews, 7
were meta-analyses, and 5 were systematic reviews and meta-analyses. According to the AMSTAR-2
criteria, 6 studies had high quality, 1 study had moderate quality, 4 studies had low quality, and 4 studies
had critically low quality. Based on the GRADE, neither evidence quality for effectiveness nor
safety was high.

Conclusions:
Immunosuppressive drug therapy is effective for patients with NMOSD, but its safety is
controversial. Due to the poor quality of evidence, reliability needs to be considered. Thus, large sample,
multi-center, double-blind, randomized controlled studies are still needed in the future.
One Pot Synthesis of Benzothiazole Derivatives by Nano Silica-based
Complex in an Aqueous Medium
Authors: Dehkharghani Rahebeh Amiri , Yari Hassan , Bardajee Ghasem Rezanejade , Akbarzadeh Torbati Niloufar 
Published: September 2022

Abstract:
We Successfully synthesized novel silica-supported Ni (II)-PLP-ONNO Schiff base/SBA-15 complex, as a mesoporous catalyst, whose characterization was determined using X-ray diffraction analysis, Fourier-transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, inductively coupled plasma-atomic emission spectroscopy, nitrogen adsorption desorption isotherms (BET-EDX) and (BET-BJH), and thermo-gravimetric analysis. As a fabricated catalyst was employed, for facile and efficient, one-pot production of various benzothiazole heterocycles by cyclocondensation reactions of 2-amionthiophenol and benzaldehyde compounds under green and mild conditions with good to excellent yields. The prepared nano catalyst can offer high stability, excellent activity, easy separation, and reusability, as well environmentally friendly, compared to its homogeneous compounds.
Vilsmeier-Haack Cyclisation as a Facile Synthetic Route to Thieno [2,3- b]
Quinolines (Part I)
Authors: Abu-Hashem Ameen A. , Gouda Moustafa A. , Abdelgawad Ahmed A.M. 
Published: September 2022

Abstract:
Quinoline ring system is extensively dispensed in natural products, especially in alkaloids.
Moreover, thieno[2,3-b]quinolines have vast biological activities, including urea transporter inhibition,
anti-microbial, antitumor, antioxidant, anti-inflammatory, and antiproliferative EGFR tyrosine
kinase inhibition. Vilsmeier-Haack is considered the most facile and promising set of synthetic routes,
leading to 2-chloro-3-formylquinolines through Vilsmeier-Haack cyclisation of N- arylacetamides,
which are subsequently used as key intermediates for the synthesis of thieno[2,3-b]quinolones
(Tqs). Many varieties of thieno[2,3-b]quinolines (Tqs) ring systems, specifically concerning medicinal
chemistry, have been developed over the past decade. In light of these facts, this review presents a
systematic and comprehensive survey of the method of preparation and the chemical reactivity of
thieno[2,3-b]quinolines through the Vilsmeier-Haack reaction. In this study, the methods of preparation
and the chemical reactivity of (Tqs) by using the Vilsmeier-Haack reaction are discussed. Since
the beginning of the 21st century, they have been advancing towards synthesizing substituted Tqs. It
can be concluded that substituted Tqs can be used as building blocks for the synthesis of polyfunctionalized
heterocyclic compounds with pharmacological interest.
Ligand-based Pharmacophore Modeling, Molecular Docking and Simulation
Studies for the Exploration of Natural Potent Antiangiogenic Inhibitors
Targeting Heat Shock Protein 90
Authors: Akhtar Salman , Sharma Neha , Sharma Mala , Faisal Mohammad , Alatar Abdulrahman A. , Kumar Rajnish , Ahmad Saheem 
Published: September 2022

Background:
HSP90, a critical molecular chaperone, has become a promising molecular target
to be involved in multiple signaling pathways of tumor progression and metastasis.

Objective:
This study intends to find a novel phytolead targeting HSP90.

Methods:
In this scenario, we employed an in silico combinatorial approach incorporating 3D-QSAR,
pharmacophore generation, pharmacokinetics, docking, MD simulation and metabolism studies.

Results:
To find a natural novel compound targeting HSP90, a ligand-based pharmacophore model was
developed, exploiting 17 diversely classified training set molecules with known experimental activity
exhausting the pharmacophore generation (HypoGen algorithm) module of Discovery Studio. The bestdeveloped
hypothesis (Hypo1) was employed against the UNPD database to screen lead compounds targeting
HSP90. Pterodontoside G (Asteraceae family)became a potent compound with the fit value of 8.80
and an estimated activity of 3.28 nM. Pterodontoside G was taken forward for analog design and pharmacokinetics
studies, followed by docking and MD simulation studies. UNPD1 came out to be the best analog
following all pharmacokinetics properties with the highest binding energy in comparison with the
parent compound and the standard drug (Ganetespib). It mapped all the features of Hypo1 with a fit value
of 8.68 and an estimated activity of 4.314 nM, exhibiting greater binding stability inside the active site of
HSP90 causing no conformational changes in the protein-ligand complex during MD analysis.

Conclusion:
The result was further supported by PASS analysis and xenosite reactivity data proposing
UNPD1 to hold potent antiangiogenic potential targeting HSP90.
Anticoccidial Effect of Iberogol and Sulfaclozine on Broilers Experimentally
Infected with Eimeria tenella
Authors: Rassouli Maryam , Khodadi Mohammad , Naeimi Saeideh 
Published: September 2022

Background:
Coccidiosis is a common infection among birds that is caused by Eimeria spp. (Protozoa, Phylum Apicomplexa). Eimeria is transmitted fecal-orally and replicated in the intestines. Coccidiosis causes economic losses and increases birds’ susceptibility to other diseases.

Methods:
In this study, the broilers were experimentally infected by Eimeria tenella and then were treated with Sulfaclozine and Iberogol. Birds were randomly divided into 5 groups (21 birds each); I: negative control, II: positive control, III: treated by Iberogol, IV: treated by Sulfaclozine, and V: treated by Iberogol+Sulfaclozine. Twenty-one-day-old chickens were infected by 10000 oocysts/ml/chicken of E. tenella. Treatments were started 1 day after oocyst observation on thirty-day-old chickens. Treatments continued for 3 days, stopped for 2 days, and again continued for the next 2 days.

Results:
The results were compared for OPG (oocyst per gram), AW (average weight), FCR (feed conversion ratio), and mortality rate among different groups. According to statistical analysis, the worst results were for the Iberogol group (III) among other treatment groups (IV, and V), and the most effective treatment was for the Iberogol+Sulfaclozine group (V).

Conclusion:
Complex herbal medications such as Iberogol can have different activities but in coccidiosis the antioxidant and anti-inflammatory effects were more than coccidiocidal effect. Therefore Iberogol increased the efficiency of Sulfaclozine.
Simultaneous Determination of Six Bioactive Components of Astragali
Radix in Rat Plasma Using Triple Quadrupole LC/MS and its Application
to a Pharmacokinetic Study
Authors: Chai Yanlan , Liu Zi , Wang Juan , Wang Jing , Zhang Kaishuo 
Published: September 2022

Aims:
In this study, a rapid, sensitive and selective Triple Quadrupole LC/MS method was developed to determine Calycosin-7-glucoside, Formononetin, Calycosin, Ononin, Cycloastragenoland Astragaloside IV from the extractive of Astragali Radixin in rat plasma, and it was validated for rat plasma as the matrix and applied for a pharmacokinetic study in rat plasma, while the internal standard was Sulfamethoxazole.

Background:
Besides, a simple, one-step deproteinization procedure was followed to prepare plasma samples, and separation was achieved on an InfinityLab Poroshell 120 column (3.0 mm × 50 mm, 1.8 μm)with a gradient mobile phase consisting of solution A (water containing 0.1% formic acid) and solution B (methanol) at a flow rate of 0.3 mL/min.

Objective:
Furthermore, multiple reaction monitoring (MRM) was used with an electrospray ionization source with the Agilent Jet Steam System (AJS-ESI) in the positive mode.

Method:
In this study, a rapid, sensitive and selective Triple Quadrupole LC/MS method was developed to determine Calycosin-7-glucoside, Formononetin, Calycosin, Ononin, Cycloastragenoland Astragaloside IV from the extractive of Astragali Radixin rat plasma, and it was validated for plasma as the matrix and applied for a pharmacokinetic study in rats, while the internal standard was Sulfamethoxazole.

Result:
Furthermore, multiple reaction monitoring (MRM) was used with an electrospray ionization source with the Agilent Jet Steam System (AJS-ESI) in the positive mode.

Conclusion:
Apart from that, a good linear response was observed within all analytes. The pharmacokinetic study on the six analytes in rats after oral administration of Astragali Radix was successfully completed by adopting this method, thusfilling a blank in pharmacokinetic studies of Astragali Radix.