bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corporate Tax Avoidance: Evidence from Vietnamese Firms
Authors: Oanh Ha Kieu , Gan Christopher 
Published: February 2022

This paper examines the effect of corporate tax avoidance on firm value using a sample of Vietnamese nonfinancial listed firms for the period 2007 to 2018. Using fixed effect, ordinary least square and system generalized method of moment estimation, the results show a positive and statistically significant relationship between corporate tax avoidance and firm value. Our result demonstrates the bright side of corporate tax avoidance at the firm level. Further analysis shows that the positive effect of corporate tax avoidance on firm value can be intensified by the effectiveness of the board of directors in monitoring management.
Frequency-dependent Amplitude Versus Offset analysis of a Cenozoic mass-transport deposit on the Namibian slope
Authors: Buckley Francis Andrew , Carnell Adam C. , Al-Maskari Safa , Cottee Lewis 
Published: February 2022

Abstract
A partially tuned, ‘soft’ seismic reflection, overlying a regional limestone marker on the west African slope, is shown to represent a sequence, up to 30 m thick, within which various individual stratigraphic units are identified, some of which display characteristics of a mass-transport deposit (MTD). The seismic reflection is described in terms of its two-way time structure, reflection amplitude pattern, complex seismic attributes and AVO response. Frequency-dependent aspects of the AVO response, resulting from velocity attenuation and dispersion of seismic signals, are shown to indicate variations in pore-fluid gas concentration. These are exploited to assess lithological, petrophysical and pore-fluid characteristics of the various sub-units within the sequence. A relative acoustic impedance inversion of the seismic data is combined with a low-frequency model, constructed from acoustic velocity data, to approximate absolute acoustic impedance characteristics of the sequence and to model behaviour of the various sub-units across the area. These pseudo-absolute impedance data are combined with evidence from AVO analysis, to construct a 2D model of the MTD unit and to generate a synthetic seismic record, which confirms the interpretation of stratigraphic, petrophysical and lithological properties of the MTD complex.
Insights into the geomorphology of the Ceará Basin, Brazil, by combining seismic attributes, machine learning, and rock-physics analyses
Authors: Leopoldino Oliveira Karen M. , Arroyo Alexandro V. , Bedle Heather , Nepomuceno Filho Francisco 
Published: February 2022

Abstract
We utilize 3D seismic data and robust rock-physics models, combined with a well dataset, to investigate the subsurface of the Mundaú sub-basin, Brazil. Seismic attributes analysis and unsupervised machine-learning approaches were able to produce high-resolution images to allow the mapping of the 3D geometry of ancient geomorphological features across stratigraphic levels, from the Albian to the Turonian interval. Significant deep-water elements were identified using seismic attributes and machine-learning techniques (i.e. channel complex, point bars, feeder channels, faults, depocentres, dendritic lobes, smaller channels and distributaries). In addition, the petrophysical analysis enhanced the subsurface characterization by employing a deep convolutional network that allowed S-wave modelling and synthetic seismic generation. The well-log data analysis validated interpretation of sand-prone deposits; in addition, the rock-physics modelling provided insight into the deposited lithologies. After the petrophysical analysis, seismic facies classification was performed using machine-learning techniques, including self-organizing maps and independent component analysis, which provided valuable insights into the geomorphology of this under-researched basin. The enhancement of seismic and petrophysical data with machine learning proves to be a useful technique for better characterizing this basin. This approach may be used on similar frontier hydrocarbon basins to help de-risk petroleum exploration.
Phosphoinositide-Binding Protein TIPE1 Promotes Alternative Activation of Macrophages and Tumor Progression via PIP3/Akt/TGFβ Axis
Authors: Cheng Yang , Bai Fuxiang , Ren Xiaolei , Sun Renhui , Guo Xiaowei , Liu Wen , Wang Bo , Yang Yongheng , Zhang Xiaolu , Xu Yong , Li Chunyang , Yang Xiaoyun , Gao Lifen , Ma Chunhong , Li Xueen , Liang Xiaohong 
Published: February 2022

AbstractMacrophages perform key and distinct functions in maintaining tissue homeostasis by finely tuning their activation state. Within the tumor microenvironment, macrophages are reshaped to drive tumor progression. Here we report that tumor necrosis factor α-induced protein 8–like 1 (TIPE1) is highly expressed in macrophages and that depletion of TIPE1 impedes alternative activation of macrophages. TIPE1 enhanced activation of the PI3K/Akt pathway in macrophages by directly binding with and regulating the metabolism of phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). Accordingly, inhibition of the PI3K/Akt pathway significantly attenuated the effect of TIPE1 on macrophage alternative activation. Tumor-associated macrophages (TAM) in human liver cancer and melanoma tissues showed significantly upregulated TIPE1 expression that negatively correlated with patient survival. In vitro and in vivo, TIPE1 knockdown in macrophages retarded the growth and metastasis of liver cancer and melanoma. Furthermore, blockade or depletion of TGFβ signaling in macrophages abrogated the effects of TIPE1 on tumor cell growth and migration. Together, these results highlight that the phosphoinositide-related signaling pathway is involved in reprogramming TAMs to optimize the microenvironment for cancer progression.Significance:This work provides insight into the fine tuning of macrophage polarization and identifies a potential target for macrophage-based antitumor therapy.
Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer
Authors: Ippolito Luigi , Comito Giuseppina , Parri Matteo , Iozzo Marta , Duatti Assia , Virgilio Francesca , Lorito Nicla , Bacci Marina , Pardella Elisa , Sandrini Giada , Bianchini Francesca , Damiano Roberta , Ferrone Lavinia , la Marca Giancarlo , Serni Sergio , Spatafora Pietro , Catapano Carlo V. , Morandi Andrea , Giannoni Elisa , Chiarugi Paola 
Published: February 2022

Abstract

Lactate is an abundant oncometabolite in the tumor environment. In prostate cancer, cancer-associated fibroblasts (CAF) are major contributors of secreted lactate, which can be taken up by cancer cells to sustain mitochondrial metabolism. However, how lactate impacts transcriptional regulation in tumors has yet to be fully elucidated. Here, we describe a mechanism by which CAF-secreted lactate is able to increase the expression of genes involved in lipid metabolism in prostate cancer cells. This regulation enhanced intracellular lipid accumulation in lipid droplets (LD) and provided acetyl moieties for histone acetylation, establishing a regulatory loop between metabolites and epigenetic modification. Inhibition of this loop by targeting the bromodomain and extraterminal protein family of histone acetylation readers suppressed the expression of perilipin 2 (PLIN2), a crucial component of LDs, disrupting lactate-dependent lipid metabolic rewiring. Inhibition of this CAF-induced metabolic–epigenetic regulatory loop in vivo reduced growth and metastasis of prostate cancer cells, demonstrating its translational relevance as a therapeutic target in prostate cancer. Clinically, PLIN2 expression was elevated in tumors with a higher Gleason grade and in castration-resistant prostate cancer compared with primary prostate cancer. Overall, these findings show that lactate has both a metabolic and an epigenetic role in promoting prostate cancer progression.

Significance:
This work shows that stromal-derived lactate induces accumulation of lipid droplets, stimulates epigenetic rewiring, and fosters metastatic potential in prostate cancer.
Cancer Statistics over Time in Northwestern São Paulo State, Brazil: Incidence and Mortality
Authors: Mafra da Costa Allini , Hernandes Isabela Campos Pereira , Weiderpass Elisabete , Soerjomataram Isabelle , Fregnani José Humberto Tavares Guerreiro 
Published: February 2022

Abstract

Background:
Population studies can serve as an essential source of information on cancer's etiology, and assessments of cancer trends over time can detect changes. This study aimed to provide statistics over time on cancer incidence and mortality in the Barretos Region, Brazil.

Methods:
Cancer incidence data were obtained from the population-based cancer registry of the Barretos Region, and mortality data were obtained from the Official Federal Database from 2002 to 2016. Age-standardized rates for incidence and mortality were calculated. Joinpoint Regression software was used to estimate the average annual percentage changes (AAPC).

Results:
Age-standardized rates of incidence increased significantly for colon cancer (AAPC: 2.2), rectum and rectosigmoid (AAPC: 2.4), liver (AAPC: 4.7), female breast (AAPC: 2.2), and thyroid cancer (AAPC: 3.8) but decreased for esophageal (AAPC: −3.2), stomach (AAPC: −4.2), lung (AAPC: −2.0), and ovarian cancer (AAPC: −5.6). The mortality increased for liver cancer (AAPC: 2.3) and decreased for pharyngeal cancer (AAPC: −5.8), stomach cancer (AAPC: −6.6), cervical uterine cancer (AAPC: −5.9), prostate cancer (AAPC: −2.4), and ovarian cancer (AAPC: −3.3).

Conclusions:
We observed decreases in some cancers related to tobacco smoking and cervical and stomach cancers related to infectious agents, showing strong regional and national prevention programs' successes. But, we also observed rises in many cancer sites linked to lifestyle factors, such as breast or colorectal cancer, without a sign of declining mortality.

Impact:
These results can impact and support cancer control program implementation and improvement at the community level and extrapolate to the state level and/or the whole country.
Long-term Residential Exposure to Air Pollution and Risk of Testicular Cancer in Denmark: A Population-Based Case–Control Study
Authors: Taj Tahir , Poulsen Aslak Harbo , Ketzel Matthias , Geels Camilla , Brandt Jørgen , Christensen Jesper Heile , Hvidtfeldt Ulla Arthur , Sørensen Mette , Raaschou-Nielsen Ole 
Published: February 2022

Abstract

Background:
The incidence rate risk of testicular cancer has increased over the last four decades, and the most significant increase has been among Caucasian men in Nordic countries. Second-generation immigrant studies indicate a significant role of environmental exposure in testicular cancer.

Methods:
We conducted a nationwide register-based case–control study including 6,390 testicular cancer cases registered in the Danish Cancer Registry between 1989 and 2014. Up to four age-matched controls for each case (n = 18,997) were randomly selected from the Civil Registration System. Ambient air pollution levels were estimated at addresses of cases and controls with a state-of-the-art air pollution modeling system.

Results:
We mostly found ORs close to 1.00 and with 95% confidence intervals (CI) spanning 1.00. Exposure during the year preceding birth was associated with ORs for nitrogen dioxide (NO2) of 0.87 (95% CI, 0.77–0.97) per 10 μg/m3 and for organic carbon of 0.84 (95% CI, 0.72–0.98) per 1 μg/m3. Exposure during the first 10 years of life was associated with ORs for organic carbon of 0.79 (95% CI, 0.67–0.93) per 1 μg/m3, for ozone (O3) of 1.20 (95% CI, 1.07–1.34) per 10 μg/m3, and for secondary inorganic aerosols of 1.07 (95% CI, 1.00–1.15) per 1 μg/m3.

Conclusions:
Early-life exposure to NO2 and organic carbon (OC) was associated with lower risk for testicular cancer whereas early-life exposure to O3 and secondary inorganic aerosols (SIA) was associated with higher risk.

Impact:
We report both positive and negative associations between ambient air pollutants and risk of testicular cancer, dependent on pollutant, exposure time window, and age at diagnosis. This is the first study to investigate such associations.
Estrogenic Activity and Risk of Invasive Breast Cancer Among Postmenopausal Women in the Nurses' Health Study
Authors: Holder Etienne X. , Houghton Serena C. , Sanchez Sylvia S. , Eliassen A. Heather , Qian Jing , Bertone-Johnson Elizabeth R. , Liu Zhenhua , Tworoger Shelley S. , Smith Martyn T. , Hankinson Susan E. 
Published: February 2022

Abstract

Background:
Estrogens increase breast cancer risk through estrogen receptor (ER)-mediated pathway activation. It is unclear whether a broader assessment of plasma compounds that lead to ER activation would be more strongly related to risk than measurement of individual estrogens.

Methods:
A prospective nested case–control study was conducted among postmenopausal women in the Nurses’ Health Study, that included 371 cases with blood samples collected prior to breast cancer diagnosis and 731 matched controls. Total estrogen pathway activity (EA) was assessed via a luciferase reporter assay using plasma-treated T47D-Kbluc (ATCC) human breast cancer cells. We also assessed the contribution of EA to risk, independent of circulating estrone, estradiol, and estrone sulfate concentrations. Multivariable ORs and 95% confidence intervals (CI) were calculated using conditional logistic regression adjusting for breast cancer risk factors.

Results:
Women in the highest, versus lowest EA quartile had an 86% increased risk of invasive breast cancer (ORQ4vsQ1, 1.86; 95% CI = 1.16–2.97). After accounting for estradiol only, a weaker association was observed (ORQ4vsQ1, 1.27; 95% CI = 0.75–2.17). No association was observed after accounting for all three estrogens (ORQ4vsQ1, 1.01; 95% CI = 0.56–1.84).

Conclusions:
A positive association between EA and breast cancer risk was observed. However, the association was substantially attenuated after accounting for levels of other estrogens.

Impact:
Our study provides a first detailed assessment of a breast cancer cell line–based EA assay and postmenopausal breast cancer risk.
The Anti-Nectin 4: A Promising Tumor Cells Target. A Systematic Review
Authors: Bouleftour Wafa , Guillot Aline , Magne Nicolas 
Published: February 2022

Abstract
The Nectin cell adhesion protein 4 (Nectin-4) is overexpressed in multiple human malignancies. Such aberrant expression is correlated with cancer progression and poor prognostic. Nectin-4 has emerged as a potential biomarker and promising targeted therapy. This review aimed to gather the current state of the literature about Nectin-4 relevance in preclinical tumor models and to summarize its clinical relevance regarding cancer. A systematic assessment of literature articles was performed by searching in PUBMED (MEDLINE) from the database inception to May 2021, following PRISMA guidelines. Preclinical models unanimously demonstrated membrane and cytoplasmic location of the Nectin-4. Furthermore, Nectin-4 was overexpressed whatever the location of the solid tumors. Interestingly, a heterogeneity of Nectin-4 expression has been highlighted in bladder urothelial carcinoma. High serum Nectin-4 level was correlated with treatment efficiency and disease progression. Finally, generated anti–drug-conjugated targeting Nectin-4 induced cell death in multiple tumor cell lines. Nectin-4 emerges as a promising target for anticancer drugs development because of its central role in tumorigenesis, and lymphangiogenesis. Enfortumab vedotin targeting Nectin-4 demonstrated encouraging results and should be extended to other types of solid tumors.
Renal Denervation Prevents Atrial Arrhythmogenic Substrate Development in CKD
Authors: Hohl Mathias , Selejan Simina-Ramona , Wintrich Jan , Lehnert Ulrike , Speer Thimoteus , Schneider Clara , Mauz Muriel , Markwirth Philipp , Wong Dickson W.L. , Boor Peter , Kazakov Andrey , Mollenhauer Martin , Linz Benedikt , Klinkhammer Barbara Mara , Hübner Ulrich , Ukena Christian , Moellmann Julia , Lehrke Michael , Wagenpfeil Stefan , Werner Christian , Linz Dominik , Mahfoud Felix , Böhm Michael 
Published: February 2022

Background:
In patients with chronic kidney disease (CKD), atrial fibrillation (AF) is highly prevalent and represents a major risk factor for stroke and death. CKD is associated with atrial proarrhythmic remodeling and activation of the sympathetic nervous system. Whether reduction of the sympathetic nerve activity by renal denervation (RDN) inhibits AF vulnerability in CKD is unknown.

Methods:

Left atrial (LA) fibrosis was analyzed in samples from patients with AF and concomitant CKD (estimated glomerular filtration rate [eGFR], <60 mL/min per 1.73 m
2
) using picrosirius red and compared with AF patients without CKD and patients with sinus rhythm with and without CKD. In a translational approach, male Sprague Dawley rats were fed with 0.25% adenine (AD)-containing chow for 16 weeks to induce CKD. At week 5, AD-fed rats underwent RDN or sham operation (AD). Rats on normal chow served as control. After 16 weeks, cardiac function and AF susceptibility were assessed by echocardiography, radiotelemetry, electrophysiological mapping, and burst stimulation, respectively. LA tissue was histologically analyzed for sympathetic innervation using tyrosine hydroxylase staining, and LA fibrosis was determined using picrosirius red.

Results:
Sirius red staining demonstrated significantly increased LA fibrosis in patients with AF+CKD compared with AF without CKD or sinus rhythm. In rats, AD demonstrated LA structural changes with enhanced sympathetic innervation compared with control. In AD, LA enlargement was associated with prolonged duration of induced AF episodes, impaired LA conduction latency, and increased absolute conduction inhomogeneity. RDN treatment improved LA remodeling and reduced LA diameter compared with sham-operated AD. Furthermore, RDN decreased AF susceptibility and ameliorated LA conduction latency and absolute conduction inhomogeneity, independent of blood pressure reduction and renal function.

Conclusions:
In an experimental rat model of CKD, RDN inhibited progression of atrial structural and electrophysiological remodeling. Therefore, RDN represents a potential therapeutic tool to reduce the risk of AF in CKD, independent of changes in renal function and blood pressure.
Association of Disease‐Specific Health Status With Long‐Term Survival in Peripheral Artery Disease
Authors: Tran Andy T. , Spertus John A. , Mena‐Hurtado Carlos I. , Jones Philip G. , Aronow Herbert D. , Safley David M. , Malik Ali O. , Peri‐Okonny Poghni A. , Shishehbor Mehdi H. , Labrosciano Clementine , Smolderen Kim G. 
Published: February 2022

Background
While peripheral artery disease (PAD) is associated with increased cardiovascular morbidity with mortality remaining high and challenging to predict, accurate understanding of serial PAD‐specific health status around the time of diagnosis may prognosticate long‐term mortality risk.

Methods and Results

Patients with new or worsening PAD symptoms enrolled in the PORTRAIT Registry across 10 US sites from 2011 to 2015 were included. Health status was assessed by the Peripheral Artery Questionnaire (PAQ) Summary score at baseline, 3‐month, and change from baseline to 3‐month follow‐up. Kaplan‐Meier using 3‐month landmark and hierarchical Cox regression models were constructed to assess the association of the PAQ with 5‐year all‐cause mortality. Of the 711 patients (mean age 68.8±9.6 years, 40.9% female, 72.7% white; mean PAQ 47.5±22.0 and 65.9±25.0 at baseline and 3‐month, respectively), 141 (19.8%) died over a median follow‐up of 4.1 years. In unadjusted models, baseline (HR, 0.90 per‐10‐point increment; 95% CI, 0.84–0.97;
P
=0.008), 3‐month (HR [95% CI], 0.87 [0.82–0.93];
P
<0.001) and change in PAQ (HR [95% CI], 0.92 [0.85–0.99];
P
=0.021) were each associated with mortality. In fully adjusted models including combination of scores, 3‐month PAQ was more strongly associated with mortality than either baseline (3‐month HR [95% CI], 0.85 [0.78–0.92];
P
<0.001; C‐statistic, 0.77) or change (3‐month HR [95% CI], 0.79 [0.72–0.87];
P
<0.001).

Conclusions
PAD‐specific health status is independently associated with 5‐year survival in patients with new or worsening PAD symptoms, with the most recent assessment being most prognostic. Future work is needed to better understand how this information can be used proactively to optimize care.
Association of Diabetes Duration and Glycemic Control With Stroke Rate in Patients With Atrial Fibrillation and Diabetes: A Population‐Based Cohort Study
Authors: Abdel‐Qadir Husam , Gunn Madison , Lega Iliana C. , Pang Andrea , Austin Peter C. , Singh Sheldon M. , Jackevicius Cynthia A. , Tu Karen , Dorian Paul , Lee Douglas S. , Ko Dennis T. 
Published: February 2022

Background
There are limited data on the association of diabetes duration and glycemic control with stroke risk in atrial fibrillation (AF). Our objective was to study the association of diabetes duration and glycated hemoglobin (HbA1c) with the rate of stroke in people with diabetes and newly diagnosed AF.

Methods and Results

This was a population‐based cohort study using linked administrative data sets. We studied 37 209 individuals aged ≥66 years diagnosed with AF in Ontario between April 2009 and March 2019, who had diabetes diagnosed 1 to 16 years beforehand. The primary outcome was hospitalization for stroke at 1 year. Cause‐specific hazard regression was used to model the association of diabetes duration and glycated hemoglobin (HbA1c) with the rate of stroke. Restricted cubic spline analyses showed increasing hazard ratios (HR) for stroke with longer diabetes duration that plateaued after 10 years and increasing HRs for stroke with HbA1c levels >7%. Relative to patients with <5 years diabetes duration, stroke rates were significantly higher for patients with ≥10 years duration (HR, 1.45; 95% CI, 1.16–1.82;
P
=0.001), while diabetes duration 5 to <10 years was not significantly different. Relative to glycated hemoglobin 6% to <7%, values ≥8% were associated with higher stroke rates (HR, 1.44; 95% CI, 1.12–1.84;
P
=0.004), while other HbA1c categories were not significantly different.

Conclusions
Longer diabetes duration and higher glycated hemoglobin were associated with significantly higher stroke rates in patients with AF and diabetes. Models for stroke risk prediction and preventive care in AF may be improved by considering patients’ diabetes characteristics.