bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential diagnosis of angina pectoris in the practice of the regional vascular center: a clinical observation
Authors: Gilyarov M. Yu. , Bogdanova A. A. , Anichkov D. A. , Kanareikina E. V. , Nesterov A. P. , Konstantinova E. V. 
Published: October 2022

The leading cause of myocardial ischemia in case of coronary atherosclerosis and coronary vasospasm combination in one patient is difficult to establish. However, it is important to know for optimal treatment strategy: choosing between beta-blockers and calcium channel blockers as a preferred treatment, need for percutaneous coronary intervention. We present a case of a 56-yearold patient who was admitted with acute coronary syndrome without ST-segment elevation, low Killip class, and low GRACE score. Stress echocardiography revealed inducible transmural myocardial ischemia (regional wall motion abnormalities and ST segment elevation on the ECG) accompanied by polymorphic ventricular tachycardia. The coronary angiography showed single-vessel moderate stenosis in the left anterior descending artery. There were no changes in comparison with previous angiography. The patient was considered to have vasospastic angina. A probable mechanism is coronary artery spasm at the site of the atherosclerotic plaque. The article is discussed the difficulties in diagnosing vasospastic angina, especially in the presence of borderline stenosis in the coronary artery. We reviewed similar cases and discussed the difficulties of a vasospastic angina diagnosis especially in the presence of moderate coronary artery stenosis, the role of the provocative tests, and the pharmacological management. Demonstrating, discussing and analyzing cases of patients with a combined mechanism of myocardial ischemia is substantiated for further improving their diagnosis and treatment.
Сlinical and allergological characteristics of chronic inflammatory diseases of the nose in patients with severe bronchial asthma receiving immunobiological therapy in the Sverdlovsk region
Authors: Kiseleva D. V. , Beltyukov E. K. , Naumova V. V. 
Published: October 2022

Introduction. Allergic rhinitis, chronic rhinosinusitis (with/without polyps) are chronic inflammatory diseases of the nose and often accompany asthma, aggravating its severity.Aim of the study. Тo determine the phenotypes, spectrum of sensitization and severity of chronic inflammatory diseases of the nose in patients with severe bronchial asthma receiving immunobiological therapy in the Sverdlovsk region.Materials and methods. The territorial register of adult patients with severe bronchial asthma (n = 85) who received immunobiological therapy in the Sverdlovsk region in October 2021 was analyzed. When diagnosing chronic inflammatory diseases of the nose, an examination by an otorhinolaryngologist and computed tomography of the paranasal sinuses were performed; were determined: the absolute number of blood eosinophils, specific IgE to inhaled allergens, including the FadiatopTM method; skin tests were performed; assessment of the severity of nasal symptoms was determined using the SNOT-22, VAS.Results. Chronic inflammatory diseases of the nose were reported in 89.4% of patients. Allergic rhinitis occurred in 54.1% of cases (n = 46). 54.3% (n = 25) were dominated by patients with a moderate course; severe course was observed in 28.3% of cases (n = 13). Allergic rhinitis in 92.3% of cases (n = 36) was accompanied by allergic asthma and in 71.4% (n = 10) – mixed. Sensitization to household allergens was more common, from seasonal allergens to tree pollen. Phadiatop was positive in all patients with allergic rhinitis and negative in patients with chronic rhinosinusitis with/without nasal polyps. Patients with chronic rhinosinusitis occurred in 35.3% of cases (n=30); nasal polyps were in 23.5% (n = 20). The highest rates of blood eosinophilia were in patients with concomitant chronic rhinosinusitis with nasal polyps – 920 cells/µl. This phenotype in 95% of cases was accompanied by non-allergic (eosinophilic) asthma.Conclusion. Severe bronchial asthma is almost always accompanied by chronic inflammatory diseases of the nose. Phadiatop shows its high informativeness in determining the phenotype of allergic rhinitis.
Double broncholytic combination of umeclidnium/ vilanterol in COPD therapy: issues of efficacy and safety
Authors: Knyazheskaya N. P. , Anaev E. Кh. , Belevskiy A. S. , Makarova M. A. 
Published: October 2022

Inhaled bronchodilators are the basis of pharmacological therapy of chronic obstructive pulmonary disease. Bronchodilation can be reached in two different ways: by stimulation of β2 -adrenoreceptors and inhibition of M3-cholinoreceptors. Combined long acting bronchodilators show additional effect on lung function and clinical outcomes of the disease. This article covers the issues of efficacy and safety of different combined bronchodilators. Chronic obstructive pulmonary disease (COPD) is a disease characterized by the limitation of air flow velocity, which is reversible incompletely. The restriction of air flow velocity is usually progressive and is associated with inflammatory response of the lungs to pathogenic particles or gases, with tobacco smoking being the main cause. COPD leads to a number of significant systemic effects that can worsen the course of the disease. It is important that COPD can be prevented and treated. The Global Strategy for the Diagnosis, Treatment and Prevention of Chronic Obstructive Pulmonary Disease (GOLD) considers long-acting inhaled bronchodilators as the basis for long-term maintenance therapy of chronic obstructive pulmonary disease. GOLD recommends the use of both long-acting anticholinergic drugs (LAMA) and long-acting β2-agonists (LABA) in all categories of patients, including as the first line in people with severe symptoms and low risk of exacerbations. bronchodilators reduce the severity of shortness of breath and other symptoms of the disease, and also increase exercise tolerance. The individual components have different application points: LAMA inhibit the effect of acetylcholine mainly on M1- and M3-muscarinic receptors, LABA stimulate β2-adrenergic receptors, increasing the content of intracellular cAMP and causing bronchodilation. Both classes of drugs potentiate each other’s activity, increasing the relaxing effect on the smooth muscles of the bronchi.
Multifaceted properties of erdostein and its place in the treatment of respiratory tract diseases
Authors: Salukhov V. V. , Nikolaev A. V. , Ivanov V. V. , Zhurkin M. A. , Chugunov A. A. , Marchenko D. A. 
Published: October 2022

Mucoactive drugs are commonly used in the treatment of respiratory diseases such as chronic bronchitis (CB) or chronic obstructive pulmonary disease (COPD), in which hypercrinia is one of the main clinical features. Erdostein is one of the most commonly used mucoactive agents for the treatment of respiratory diseases. Erdostein is a drug approved for the treatment of acute and chronic lung diseases, originally developed as a mucolytic agent. It belongs to a family of thiol-based drugs, which, in addition to mucolytic action, also have antioxidant and anti-inflammatory properties and exhibit antibacterial activity against various types of bacteria. Erdosteine is a prodrug that is converted to the active metabolite M1 (MET 1), which has mucolytic properties. Experimental studies have confirmed that erdosteine prevents or reduces damage to lung tissue caused by oxidative stress, and also regulates the production of reactive oxygen species. The RESTORE study, the only study that examined the effect of a thiol-based drug in chronic obstructive pulmonary disease (COPD) with frequent exacerbations, confirmed that erdosteine significantly reduces the risk of acute exacerbations of COPD, reduces their duration, and also reduces the risk of hospitalization for COPD. The preventive effect of erdosteine against exacerbations of COPD was not affected by the presence or absence of inhaled corticosteroids (ICS) or the number of eosinophils in the blood. Recent studies on the pharmacological effects of erdosteine have shown promising results, which paves the way for the use of additional pharmacological effects of erdosteine as promising therapeutic strategies in patients with pulmonary diseases.
Can guava (Psidium guajava) leaf extracts develop an indigenous, simplified tool for a semi-quantitative assessment of iron in groundwater?
Authors: Rahman Sabuktagin , Saha Nobonita , Sarwar Sneha , Shamim Abu Ahmed , Shaheen Nazma 
Published: October 2022

Abstract
Iron present in the drinking groundwater is attributed to the low burden of iron deficiency (ID) in Bangladesh. The supplemental anemia prevention strategies involving iron need a cautious approach due to the excess load of iron and the side effects. The present pilot study examined the potential of the guava leaf extracts to use as a natural reagent for the assessment of iron in groundwater. Eighteen households with the drinking source of groundwater were randomly selected. Guava leaves were crushed and the shreds of the leaves were mixed with the water sample. Changes of water color were photographed. Five groups were identified – ‘whitish’, ‘shades of pink’, ‘shades of purple’, ‘light black’ and the ‘frank black’. The iron concentration was measured by a test kit device. Each color group was assigned a number on the ordinal scale 1–5. Statistical correlation and agreements were performed between the methods. The positive correlation (Kendall's tau b: 0.89, p &lt; 0.000) and the agreements (Kappa: 0.77, p &lt; 0.000; rho_c: 0.73, p &lt; 0.000) were observed. Guava leaf extracts may standardize an indigenous tool for a semi-quantitative measurement of groundwater iron content. Validation of the tool thus may aid in the design and evaluation of the iron supplementation and fortification programs.
Analytic network process for local scour formula ranking with parametric sensitivity analysis and soil class clustering
Authors: Annad Mohamed , Lefkir Abdelouahab 
Published: October 2022

AbstractPrediction of scour depth around bridge piers during flood events has been and continues to be regarded as a paramount concern for researchers of local scour, and many empirical formulas have been proposed. Because of the multiplicity and variability of these formulas, it remains extremely delicate to choose the correct formula among the many available. This study aims to develop a new framework to compare the different formulas currently used for the evaluation of local scour. For this purpose, 18 distinctly different formulas are selected and then evaluated using a large set of field-measured scour data. The rating is pronounced along three main streambed granulometric distributions. The validation process is performed using the Analytical Network Process approach (ANP), in which the already available conventional weights are re-evaluated and updated using various analyses, notably in terms of statistics, sensitivity, and correlation. The validation and comparison results of these 18 scour formulas reveal that the efficiency of a given particular formula depends on the type of stream soil studied. Furthermore, the scour formulas that include parameters having a geometrical dimension provide better performances.
Disinfection of Virtual Reality Devices in Health Care Settings: In Vitro Assessment and Survey Study
Authors: Roberts Scott C , Havill Nancy L , Flores Rosa M , Hendrix II Curtis Anthony , Williams Maximillian J , Feinn Richard S , Choi Steven J , Martinello Richard A , Marks Asher M , Murray Thomas S 
Published: October 2022

Background
Virtual reality (VR) devices are increasingly used in health care settings. The use among patients has the potential to unintentionally transmit pathogens between patients and hospital staff. No standard operating procedure for disinfection exists to ensure safe use between patients.

Objective
This study aims to determine the efficacy of disinfectants on VR devices in order to ensure safe use in health care settings.

Methods
Three types of bacteria were inoculated onto porous and nonporous surfaces of 2 VR devices: the Meta Oculus Quest and Meta Oculus Quest 2. Disinfection was performed using either isopropyl alcohol or alcohol-free quaternary ammonium wipes. A quantitative culture was used to assess the adequacy of disinfection. A survey was separately sent out to VR device technicians at other pediatric health care institutes to compare the methods of disinfection and how they were established.

Results
Both products achieved adequate disinfection of the treated surfaces; however, a greater log-kill was achieved on nonporous surfaces than on the porous surfaces. Alcohol performed better than quaternary ammonium on porous surfaces. The survey respondents reported a wide variability in disinfection processes with only 1 person reporting an established standard operating procedure.

Conclusions
Disinfection can be achieved through the use of either isopropyl alcohol or quaternary ammonium products. Porous surfaces showed lesser log-kill rates than the nonporous surfaces, indicating that the use of an added barrier may be of benefit and should be a point of future research. Given the variability in the disinfection process across health care systems, a standard operating procedure is proposed.
Plan Maestro de Educación Ambiental: Costa Rica
Authors: Estrella Guier Serrano  
Published: October 2022

El Plan Maestro de Educación Ambiental para Costa Rica fue un proyecto ideado por Mario Boza y Álvaro Ugalde (considerados los padres de los parques nacionales de este país). Se formuló en los años 1987-88, desde la Fundación Neotrópica y con apoyo de la fundación Mac Arthur de los Estados Unidos. Fue el primer esfuerzo del país con financiamiento específico para impulsar la educación ambiental a todo nivel. El plan de trabajo incluyó diversas etapas con el fin de obtener la información necesaria para la formulación del plan de acción. Se contó con apoyo gubernamental, mediante la creación por decreto ejecutivo de una Comisión Nacional de Educación Ambiental, encargada de impulsar su ejecución por parte de las instancias correspondientes.
Energy and Carbon Loss Management in an Electric Bus Factory for Energy Sustainability
Authors: Savran Efe , Yavaş Özcan , Erolnalbur Berrak , Karpat Fatih 
Published: October 2022

Increasing energy need brings people one step closer to energy saving and alternative sources. The search for reliable and sustainable resources also contributes greatly to technological progress. Thanks to advanced technology, energy use becomes more efficient. However, the concept of sustainability emerges in the field of energy as in other sectors. It is expected that electric vehicles, which have started to increase in interest in recent years, will make a positive contribution to issues such as environmental protection and sustainable energy. In addition, production centers for electric vehicles should also be sustainable and sensitive to carbon emissions. In this study, energy and carbon loss assessment was carried out in an electric bus manufacturing factory. With the help of linear regression analysis, the data of the last 3 years were evaluated. Moreover, as a result of internal audits, energy loss points were determined. As a result of this study, sustainability, carbon loss, and energy management issues in an electric vehicle production factory were evaluated and guiding qualities for today's and future technology companies were revealed.
The Antipsychotic Dopamine 2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA:3-Ketoacid CoA Transferase
Authors: Tabatabaei Dakhili Seyed Amirhossein , Greenwell Amanda A. , Yang Kunyan , Abou Farraj Rabih , Saed Christina T. , Gopal Keshav , Chan Jordan S.F. , Chahade Jadin J. , Eaton Farah , Lee Crystal , Velázquez-Martínez Carlos A. , Crawford Peter A. , Glover J.N. Mark , Al Batran Rami , Ussher John R. 
Published: October 2022

Despite significant progress in understanding the pathogenesis of type 2 diabetes (T2D), the condition remains difficult to manage. Hence, new therapeutic options targeting unique mechanisms of action are required. We have previously observed that elevated skeletal muscle succinyl CoA:3-ketoacid CoA transferase (SCOT) activity, the rate-limiting enzyme of ketone oxidation, contributes to the hyperglycemia characterizing obesity and T2D. Moreover, we identified that the typical antipsychotic agent pimozide is a SCOT inhibitor that can alleviate obesity-induced hyperglycemia. We now extend those observations here, using computer-assisted in silico modeling and in vivo pharmacology studies that highlight SCOT as a noncanonical target shared among the diphenylbutylpiperidine (DPBP) drug class, which includes penfluridol and fluspirilene. All three DPBPs tested (pimozide, penfluridol, and fluspirilene) improved glycemia in obese mice. While the canonical target of the DPBPs is the dopamine 2 receptor, studies in obese mice demonstrated that acute or chronic treatment with a structurally unrelated antipsychotic dopamine 2 receptor antagonist, lurasidone, was devoid of glucose-lowering actions. We further observed that the DPBPs improved glycemia in a SCOT-dependent manner in skeletal muscle, suggesting that this older class of antipsychotic agents may have utility in being repurposed for the treatment of T2D.
Aplikasi Variasi Isolat Bakteri Pada Pupuk Cair Limbah Pasar Ikan Terhadap Pertumbuhan dan Produksi Bawang Merah (Allium ascalonicum L)
Authors: Murdianti Imas , Sujarwanta Agus , Achyani Achyani 
Published: October 2022

Abstrak: Produksi bawang merah dapat ditingkatkan melalui perbaikan teknis budidaya, antara lain dengan cara aplikasi variasi isolate bakteri pada pupuk cair limbah pasar ikan. Pupuk cair limbah pasar ikan dengan variasi isolate bakteri tertentu menunjukkan pengaruh terhadap pertumbuhan dan produksi bawang merah yang lebih baik. Penelitian ini bertujuan mengkaji respon pertumbuhan dan produksi bawang merah terhadap pemberian pupuk organik cair dari limbah pasar ikan dengan variasi isolate bakteri dan mendapatkan variasi isolate bakteri pada pupuk cair limbah pasar ikan terbaik pengaruhnya terhadap pertumbuhan dan produksi bawang merah. Penelitian ini dilakukan selama 8 minggu (56 hari) setelah tanam, dan jenis penelitian ini adalah eksperimen menggunakan Rancangan Acak Lengkap (RAL) dengan 5 perlakuan dan 1 kontrol serta 5 kali ulangan. Parameter yang digunakan meliputi tinggi tanaman, jumlah helai daun, dan jumlah umbi tanaman bawang merah. Data utama ditabulasikan dan dianalisis menggunakan aplikasi SPSS 26.0 dengan uji Analisis Varians (ANOVA) Satu Arah atau One Way Anova. Disimpulkan bahwa aplikasi pupuk cair limbah pasar ikan variasi P4 dengan jumlah 12 isolat bakteri (komposisi 100% limbah cair pasar ikan) memberikan pengaruh paling optimal terhadap pertumbuhan ( tinggi, jumlah helai daun, dan jumlah umbi ) pada tanaman bawang merah (Allium ascalonicum L)

Abstrack. The production of shallots can be increased through technical improvements in cultivation, among others by the application of various bacterial isolates in fish market waste liquid fertilizer. Liquid organic fertilizer from fish market waste with a certain variety of bacterial isolates showed a better effect on growth and production of shallots. This study aims to examine the response of growth and production of shallots to the application of liquid organic fertilizer from fish market waste with a variety of bacterial isolates and to obtain variations of bacterial isolates in liquid fertilizer from fish market waste which have the best effect on the growth and production of shallots. This research was conducted for 8 weeks (56 days) after planting, and the type of this research was an experimental study using a completely randomized design (CRD) with 5 treatments and 1 control and 5 replications. Parameters used include plant height, number of leaves, and number of bulbs of shallot plants. The main data were tabulated and analyzed using the SPSS 16.0 application with the One Way ANOVA test. It was concluded that the application of liquid fertilizer from fish market waste variation P4 with a total of 12 bacterial isolates (composition of 100% fish market wastewater) gave the most optimal effect on growth (height, number of leaves, and number of bulbs) on shallot (Allium ascalonicum L) plants.
PENGEMBANGAN LEMBAR KERJA PESERTA DIDIK (LKPD) INKUIRI TERBIMBING BERBASIS E-LEARNING PADA MATERI PLANTAE
Authors: Agustina Evi , Muhfahroyin Muhfahroyin , Sujarwanta Agus 
Published: October 2022

Abstrak: Proses pembelajaran tidak terbatas hanya bertempat disekolah, bertemu dan berinteraksi dengan guru secara langsung, pembelajaran bisa dilakukan dimana saja dan kapan saja sesuai dengan kondisi. Adanya virus pandemi covid-19 membuat peserta didik belajar secara mandiri, untuk memfasilitasi peserta didik maka perlu adanya bahan ajar berupa LKPD yang dapat membimbing peserta didik belajar secara mandiri. Tujuan pengembangan LKPD dengan model inkuiri terbimbing berbasis e-learning dapat memberikan inovasi baru dalam proses pembelajaran dengan pemanfaatan teknologi informasi yang semakin canggih. Sehingga meminimalisir masalah yang terjadi dalam proses pembelajaran di masa pandemi.

Kata kunci : LKPD, Inkuiri Terbimbing, Schoology

Abstract: The learning process is not limited to only taking place in schools, meeting and interacting with teachers directly, learning can be done anywhere and anytime according to conditions. The existence of the covid-19 pandemic virus makes students learn independently, to facilitate students, it is necessary to have teaching materials in the form of LKPD that can guide students to learn independently. The purpose of developing LKPD with a guided inquiry model based on e-learning can provide new innovations in the learning process by utilizing increasingly sophisticated information technology. So as to minimize problems that occur in the learning process during the pandemic.

Keywords: LKPD, Guided Inquiry, Schoology
PENGARUH BUDAYA KERJA DAN SUPERVISI AKADEMIK TERHADAP PROFESIONALISME GURU SMK
Authors: Rahmawati Rahmawati , Noor Marzuki , AM Sudirman 
Published: October 2022

Guru adalah penentu dalam pendidikan. Penerapan kompetensi pedagogik sangat penting karena seorang guru diharapkan mampu dengan materi pembelajaran. Kompetensi guru perlu dievaluasi dan dibimbing, sehingga dapat dilihat dan diukur tingkat keberhasilannya untuk meningkatkan kualitas dan mutu Pendidikan. Penelitian ini bertujuan (1) Untuk mendeskripsikan kekuatan pengaruh budaya kerja terhadap kompetensi pedagogik, (2) Untuk mendeskripsikan kekuatan pengaruh supervisi akademik terhadap kompetensi pedagogik, dan (3) Untuk mendeskripsikan kekuatan pengaruh budaya kerja dan supervisi akademik secara bersama-sama terhadap kompetensi pedagogik. Populasi 104 dan sampel 51 responden dengan menggunakan rumus Slovin. Pengambilan data menggunakan angket dan regresi menjadi alat penelitian. Hasilnya adalah (1) Terdapat pengaruh positif dan signifikan budaya kerja terhadap kompetensi pedagogik guru SMK se-Kecamatan Seputih Mataram Kabupaten Lampung Tengah, sebesar 62,2% dengan persamaan regresi Ŷ = 23,165 + 0,321X1. (2) Terdapat pengaruh positif dan signifikan supervisi akademik terhadap kompetensi pedagogik guru SMK se- Kecamatan Seputih Mataram Kabupaten Lampung Tengah, sebesar 79,7% dengan persamaan regresi Ŷ = 3,074 + 0,749X2. (3) Terdapat pengaruh positif dan signifikan budaya kerja dan supervisi akademik secara bersama-sama terhadap kompetensi pedagogik guru SMK se-Kecamatan Seputih Mataram Kabupaten Lampung Tengah sebesar 83,3% dengan persamaan regresi Ŷ = 3,584 + 0,115X1 + 0,573X2. Dapat disimpulkan bahwa budaya kerja dan supervisi akademik berpengaruh positif terhadap kompetensi pedagogik. Peneliti menyimpulkan budaya kerja dan supervisi akademik dapat meningkatkan kompetensi pedagogik, sehingga jika dilaksanakan dengan maksimal maka kompetensi pedagogik akan semakin meningkat.