bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of mean sea-level rise on the long-term evolution of a mega-nourishment
Authors: Ribas Francesca , Portos-Amill Laura , Falqués Albert , Arriaga Jaime , Marcos Marta , Ruessink Gerben 
Published: August 2022

Abstract
Mean sea-level rise (MSLR) will induce shoreline recession, increasing the stress on coastal systems of high socio-economic and environmental values. Localized mega-nourishments are meant to alleviate erosion problems by diffusing alongshore over decades and thus feeding adjacent beaches. The 21-st century morphological evolution of the Delfland coast, where the Sand Engine mega-nourishment was built in 2011, was simulated with the Q2Dmorfo model to assess the Sand Engine capacity to protect the area against the effects of MSLR. The calibrated and validated model was forced with historical wave and sea-level data and MSLR projections until 2100 corresponding to different Representative Concentration Pathways (RCP2.6, RCP4.5 and RCP8.5). Results show that the Sand Engine diffusive trend will continue in forthcoming decades, with the feeding effect to adjacent beaches being less noticeable from 2050 onward. Superimposed to this alongshore diffusion, MSLR causes the shoreline to recede because of both passive-flooding and a net offshore sediment transport produced by wave reshaping and gravity. The existing feeding asymmetry enforces more sediment transport to the NE than to the SW, causing the former to remain stable whilst the SW shoreline retreats significantly, especially from 2050 onward. Sediment from the Sand Engine does not reach the beaches located more than $6$~km to the SW, with a strong shoreline and profile recession in that area, as well as dune erosion. The uncertainties in the results are dominated by those related to the free model parameters up to 2050 whilst uncertainties in MSLR projections prevail from 2050 to 2100.
Volume of Fluid Simulations of Heat Transfer in Liquid-Liquid Segmented Flows in Microfluidic channel
Authors: Bashir Shazia , Shaukat Saad , Inc Mustafa , Bashir Muhammad , Maqbool Ayesha , Iqbal Muhammad Sajid , Afzal Farkhanda 
Published: August 2022

Abstract
This study presents the investigations on the effect of heat transfer on droplet formation in T-type microfluidic channel. Mineral oil acts as a continuous phase, and water acts as a dispersed phase. The Volume of Fluid model is used to investigate the formation of droplets of water in oil in the microchannel. The physical properties of both fluids change with an increase in temperature of dispersed phase, of which the dominant properties are viscosities of fluids and interfacial tension. The parameters such as droplet diameter, distance between two consecutive droplets and detachment time were studied with respect to temperature in the range of 300 K to 325 K. These properties are also studied at different flow rate ratios 0.125, 0.25, and 0.5. The distance between two consecutive droplets was found to decrease with the increase in temperature due to the rapid motion of droplets in the temperature zone. The droplet detachment time also decreases, due to the decrease in interfacial forces which hold the droplets in the dispersed phase. The droplet diameter decreases initially with the increase in temperature, but it was observed that after 320 K the diameter of the droplet increases due to the coalescence of two consecutive droplets downstream in the microchannel. This temperature is reported as a limiting condition for thermally controlled water-in-oil microemulsions.
A Pan-Cancer Analysis of SRD5A1, a Potential New Carcinogenic Indicator Related to Immune Infiltration and Prognosis of UCEC
Authors: Xie Li-Hua , Zhang Yan-hui , Xu Ye , Hu Fen , Zheng Chen-hua , Wu Cheng , Xu Jiabao 
Published: August 2022

Abstract
Background: Steroid 5-Alpha-reductase type I (SRD5A1) converts testosterone to dihydrotestosterone and regulates sex hormone levels, which facilitates tumor incidence or progression. However, the molecular mechanism behind SRD5A1's role in pan-cancer remains unknown. Methods: RNA-seq data from TCGA and the Genotype-Tissue Expression (GTEx) database were used to examine SRD5A1 expression. String, HPA, GEPIA2, TIMER2, and cBioportal database were used to explore the protein and immune cell infiltration information of SRD5A1. The R package “ClusterProfiler” was used to conduct KEGG and GO enrichment analyses, and CancerSEA was used to investigate the functional heterogeneity of cancer cells. Results:SRD5A1 expression was differentially and higher predicted worse survival status in most tumor samples. Increased expression of SRD5A1 was detrimental to the clinical prognoses of cancer patients, especially UCEC. SRD5A1 expression was closely correlated with T cell infiltration and immune checkpoints. There were significant correlations between SRD5A1 expression and tumor mutation burden (TMB) or microsatellite instability (MSI)in several cancers. High SRD5A1 levels were associated with the infiltration of myeloid-derived suppressor cells (MDSCs) and Th2 subsets of CD4+ T cells in most cancers. Enrichment analyses revealed that SRD5A1 participated in Transcription Androgen Receptor nuclear signaling and Metabolism. Finally, we validated pan-cancer SRD5A1 expression, and its impacts on immune infiltrate in UCEC.Conclusion:Our results suggest that SRD5A1 may contribute to the immune infiltration in the tumor microenvironment. SRD5A1 might synergize with other immune checkpoints serve as a carcinogenic indicator related to prognosis in pan-cancer, especially UCEC, and shed new light on therapeutics of cancers for clinicians.
Timing and controlling D3+ formation from bimolecular reaction in a D2-D2 dimer
Authors: Lin Kang , Zhou Lianrong , Jiang Zhejun , Qiang Junjie , Jiang Wenyu , Zhang Wenbin , Lu Peifen , Dorner Reinhard , Wu Jian 
Published: August 2022

Abstract
The light-driven formation of trihydrogen cation has been attracting considerable attention in multidisciplinary frontiers due to its vital role in interstellar chemistry. To understand the formation dynamics, most previous studies are focused on creating H3+/D3+ from unimolecular reactions of various organic molecules. Here, we observe and characterize the ultrafast formation dynamics of D3+ from bimolecular reaction starting from a D2-D2 dimer by performing pump-probe experiments using ultrashort laser pulses. We then control the emission direction of D3+ in the bimolecular reaction using a tailored two-color femtosecond laser field. The underlying control mechanism is in line with what is known from the light-control of electron localization in the bond breaking of single molecules. Our results pave the way towards the real-time visualization and coherent control of the light-induced bimolecular reactions with unprecedented precision.
Nonlethal effects of predation: Presence of insectivorous birds affects the behaviour and level of stress in insects
Authors: Kollross Jan , Jancuchova-Laskova Jitka , Kleckova Irena , Freiberga Inga , Kodrik Dalibor , Sam Katerina 
Published: August 2022

AbstractInsect exposure to their predators can affect individuals and community processes, through direct consumption or nonlethal effects. However, the links between behavioural and physiological responses and stimuli needed for the development of fear are not clear. We subjected the desert locusts (Schistocerca gregaria) to three nonlethal treatments, using the great tits(Parus major)as a potential predator. The treatments involved: (1)bird- presence of a great tit and its calls, (2)call- great tit calls only, (3)control- without any treatment. In the first behavioural laboratory experiment, locusts were offered food and shelter in an open space. The duration of hiding and feeding indicated fear responses. In the second laboratory experiment with the same three treatments, levels of the adipokinetic hormone (AKH) were evaluated in the central nervous system (CNS) and haemolymph. In the third experiment in an outdoor aviary, birds were further away from locusts before we measured physiological response. In the first experiment, the locusts were hiding for significantly longer and feeding for a shorter time during bird treatment than during the call or control treatments. The proximity of birds to locusts in the laboratory experiment elicited a significant increase in the AKH levels in the CNS and haemolymph as compared to the call/control treatments. The outdoor experiment confirmed the results for levels of AKH in CNS but not haemolymph. The proximity of predators, but not only their call, affected both behavioural and physiological responses of locusts.
Novel magnetic excitations beyond the single- and double-magnons
Authors: Elnaggar Hebatalla , Nag Abhishek , Haverkort Maurits , Zhou Ke-Jin , de Groot Frank 
Published: August 2022

Abstract
Conventional wisdom suggests that one photon that carries one unit of angular momentum can change the spin angular momentum of a magnetic system with one unit (ΔMs = ±1) at most. This would imply that a two-photon scattering process can manipulate the spin angular momentum of the magnetic system with a maximum of two units. Here we examine the fundamental limit of the photon-driven transport of angular momentum by studying the magnon spectrum of α-Fe2O3 using resonant inelastic x-ray scattering. We discovered a cascade of higher-rank magnons carrying double, triple, quadruple, and quintuple the spin angular momentum of a single-magnon. Guided by theoretical calculations, we reveal how a two-photons scattering process can create exotic higher-rank magnons and the relevance of these quasiparticles for magnon-based applications.
Factors influencing patients' intention to use hospital information system in the old-new transition period: A case study of Hospital Examination Reservation System
Authors: Wang Qi , Ma Yingjie , Mao Jian , Song Jingyan , Xiao Mingzhao , Zhao Qinghua , Yuan Fang , Wang Haoding , Hu Lei 
Published: August 2022

Abstract
Objective
This study established a theoretical model to analyze the factors influencing patients’ intention to use a new Hospital Information System (HIS) and provide suggestions for hospital administrator: A case study of Hospital Examination Reservation System(HERS).
Background
The successful application of the new HIS could not only optimize the hospital examination process, but also improve the overall utilization rate of hospital examination equipment, and it could also improve patient satisfaction. But the key is how to successfully help the new HIS to transition.
Method
The target population of this study was patients who had used the HERS, and the questionnaire was filled through the Sojump. Structural equation modeling was used to analyze the data.
Results
Habit was the main positive factor influencing the behavioral intention of using HERS (β = 0.539, P < 0.001), followed by patient innovation (β = 0.252, P < 0.001), effort expectancy (β = 0.209, P < 0.001), facilitating conditions (β = 0.192, P < 0.001), and perceived privacy exposure have a significantly negative effect on behavioral intention (β=-0.126, P < 0.001). The above five variables explained 65.4% of the variation in behavioral intention.
Conclusion
In order to operate the new system better, hospitals could cultivate patients' HERS usage habits. Patients value the recommendations from doctors and innovative patients, and care about the privacy and the ease of operation, so hospitals could Invite patients with high innovation to recommend HERS to others and arrange staffs to guide and help the use of this system. And it is also important of training doctors.
Oral health disparities among geriatric population according to sexual difference in South Korea: A Nationwide population- based study
Authors: Park Hyang-Ah , Shin Soon-Hee , Ryu Jae-In 
Published: August 2022

Abstract
The proportion aged 60 years or older in the world's population is expected to double by 2050. In general, they have many complex diseases and poor oral health status. Oral health is one of the important health indicators of elderly people and it is affected by diverse factors, such as socioeconomic status. In this study, gender was considered as an associated factor that is closely related to edentulism. The sexual difference might be more influential within the geriatric population because of lower economic and educational backgrounds in that stage. Edentulism was significantly higher among elderly females than males, when combined with the education level. The lower the level of education, the higher the prevalence of edentulism as much as 24~28 times, especially in female (P=0.002). These findings suggest a more complex relationship between oral health, socioeconomic status, and gender.
Antisocial personality disorder and related factors of adolescents in multi-ethnic areas of China: A cross-sectional study
Authors: Zhou Qiao , Wan Yu , Wang Jianhua , Yang Liying , Shen Fang , Ni Qinmin , Tan Qiu , Dong Liting , Yang Jing , Peng Hong , Zhang Shixiao , Huang Jibiao , Gao Xueyan , Fu Yanfen 
Published: August 2022

Abstract
Background Antisocial personality disorder (ASPD) has a high incidence and does serious harm to society and families. Although it has received widespread attention, there is no research on the relationship between ASPD and ethnic groups. Therefore, our goal is to study the prevalence, potential risk factors and ethnic correlation of ASPD among adolescents in multi-ethnic areas of China.Methods We collected a sample of 2571 adolescents in China using a cross-sectional study. SPSS22.0 software was used with chi-square test for univariate analysis, logistics regression for multivariate regression analysis, to explore the distribution of ASPD and the relationship between social demographic factors.Results The positive rate of ASPD screening among adolescents in multi-ethnic areas in China is 24.2% (95%CI:22.5~25.8). Univariate chi-square test showed that gender, age, educational background, nationality, subjective family economic situation, single-child family, father's education level and mother's education level were related to the positive rate of ASPD screening, and the difference was statistically significant. Further logistics regression analysis showed that male (OR=3.541,95%CI: 2.915-4.301), Lisu nationality (OR=1.750,95%CI: 1.259-2.433) and single-child family (OR=,95%CI: 1.028-1.776) were independent risk factors for ASPD. Age ≥ 19 (OR=0.394,95%CI：0.219~0.712) and educational background of senior high school (OR=0.451,95%CI：0.311~1.106) are protective factors of ASPD.Conclusions High positive rate of ASPD screening among adolescents in multi-ethnic areas of China. Gender, age, educational background, nationality, subjective family economic situation, single-child family, father's education level and mother's education level are the influencing factors of ASPD. Male, Lisu nationality and single-child family were independent risk factors for positive ASPD screening, while age ≥ 19 years old and high school education were protective factors for ASPD.
Factors Affecting Health Insurance Utilization among Insured Population: Evidence from Health Insurance Program of Bhaktapur District of Nepal
Authors: Ghimire Sushmita , Ghimire Sailaja , Khanal Pratik , Sagtani Reshu Agrawal , Paudel Sudarshan 
Published: August 2022

Abstract
Background
The Government of Nepal introduced the family-based health insurance program in 2016 to increase financial protection and improve access to health care services. The aim of the study was to assess factors associated with the utilization of health insurance among insured population in an urban district of Nepal.
Methods
A cross-sectional survey using face-to-face interviews was conducted in 224 households of Bhaktapur district of Nepal. Household heads were interviewed using a structured questionnaire. Logistic regression with weighted analysis was done to identify predictors of service utilization among the insured residents.
Results
The prevalence of health insurance service utilization at the household level in the Bhaktapur district was 77.2% (n = 224). The number of elder members in the family (AOR 2.7, 95% CI 1.09–7.07), having family member with chronic illness (AOR 5.10, 95% CI 1.48–17.56), willingness to continue health insurance (AOR 2.18, 95% CI 1.47–3.25) and membership duration (AOR 1.14, 95% CI 1.05–1.24) were significantly associated with the utilization of the health insurance at the household level.
Conclusion
The study identified a particular group of the population who were more likely to utilize health insurance services, including the chronically ill and elderly. Health insurance program in Nepal would benefit from strategies to increase population coverage in health insurance, improve quality of health services, and retain members in the program.
Raising awareness for the lack of interest in STEM of primary school learners in Kazakhstan: experiences and perspectives
Authors: Ibrayeva Elvira Serikovna , Shaushekova Bayan Kyrykbayevna 
Published: August 2022

Abstract
The article deals with a specially developed program for the formation of STEM knowledge for primary schoolchildren in the system of additional education. The article listed the problems of the development of scientific and technical knowledge, emphasized the lack of interest and motivation of schoolchildren, lack of educational programs in the field of study. The article describes the experiences of foreign countries, the implementation of STEM in the educational process, which indicated the need to create a pedagogical system for the formation of scientific and technical knowledge. The purposes of this study is to identify the effectiveness of the model for the formation of knowledge in the field of STEM among students of junior classes in the system of additional education. The model of formation of knowledge in the field of STEM among younger schoolchildren in the system of additional education is described. Various methods of data collection were used during the three-year study with the participation of students of the experimental and control groups. Statistical significance of the obtained results was checked using Student's t-test. The comparative analysis of the data confirmed the differences in the dynamics of the formation of STEM competencies of junior schoolchildren in the experimental and control groups. The number of students experienced mental group, experiencing difficulties in scientific and technical activities, decreased to 53%. In the control group, improvement in each of the criteria averaged 6%, which is statistically insignificant. A model of the formation of STEM knowledge among younger schoolchildren in the system of additional education has been developed, which has confirmed its effectiveness for the development of students' ability to conduct scientific and technical activities, practical experiments in a game educational environment.
Clinical outcomes after endovascular thrombectomy in different triage methods
Authors: Jiang Fucheng , Yin Wenpeng , Jia Jianwen , Zhong Hongliang , Yang Hongchao , Huang Jvmei , Wang Yang , Liu He 
Published: August 2022

Abstract
Objective: We compare three treatment strategies for acute ischemic stroke (AIS) for effectiveness and safety: 1) patients seen at a primary stroke center (PSC), started on emergency intravenous thrombolysis (IVT) and then transported to a comprehensive stroke center (CSC) [“drip and ship” (DS)]; 2) patients immediately transferred to CSC without starting IVT, for mechanical thrombectomy (MT) [“non-drip and ship” (non-DS)]; and 3) patients admitted directly to the CSC for assessment and subsequent bridging thrombolysis (BT) [“mothership” (MS)].Methods: We retrospectively reviewed the data of patients that underwent MT for AIS from November 2020 to November 2021 at our institution. Patients were divided into three groups: DS, non-DS, and MS, as defined above. Time course, multimodal CT features and clinical results were compared among the three groups, including onset-to-needle time (OTN), onset-to-groin time (OGT), onset-to-PSC time (OTP), PSC-to-groin-puncture time (PTG), door to needle time (DNT), door to puncture time (DPT), intravenous thrombolysis to puncture time (IVT-P), volumes of ischemic core and ischemic penumbra, postoperative modified thrombolysis in cerebral infarction (mTICI) score, postoperative hemorrhagic transformation and malignant edema, 90-day modified Rankin scale (mRS) score and mortality.Results: The study included 41 patients, with 12, 12, and 17 patients in DS, non-DS, and MS groups, respectively. Baseline characteristics, such as age, gender, past history, and National Institutes of Health Stroke Scale (NIHSS) score, did not differ among the three groups. OGT differed among the three groups (P <0.001). The DS group had a significantly longer OGT than the MS group (DS median, 390 minutes; interquartile range [IQR], 326-500 minutes versus MS median, 235 minutes; IQR, 159-270 minutes; P <0.001), a significantly shorter OTP than the non-DS group (DS median, 94 minutes; IQR, 82-116 minutes versus non-DS median, 463 minutes; IQR, 335-787 minutes; P <0.001), and a longer PTG than the non-DS group (DS median, 271 minutes; IQR, 204-364 minutes versus non-DS median, 162 minutes; IQR, 111-240 minutes; P =0.002). OTN was longer in the MS group than the DS group (MS, 150.9 ± 48.8 minutes versus DS, 111.7 ± 47.7 minutes; P = 0.041). IVT-P was shorter in the MS group compared with DS (MS median, 56 minutes; IQR, 39.5-102 min versus DS median, 275 minutes; IQR, 186-390.75 min, P <0.001). No significant differences were present among groups in volume of the ischemic core, ischemic penumbra, rate of recanalization, malignant edema, hemorrhage transformation, number with mRS ≤2 at 3 months, or mortality at 3 months.Conclusions: DS is a safe and effective method, with no increased risk of postoperative hemorrhage transformation, malignant edema or death compared to non-DS and MS methods.