bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sistematização da assistência de enfermagem perioperatória em pacientes submetidos à angioplastia coronária transluminal percutânea
Authors: Silva Amanda Tabosa Pereira da , Santos Déborah Maria Carolline dos , Oliveira José Clebson Silva Rodrigues de , Silva Júlia Sthefane Cabral Gonsalves , Silva Lara Rayane Santos , Queiroz Larissa Moreira da Silva , Silva Lucas Antonio de Lima , Silva Marina Maria da , Cavalcanti Marilia Gabrielle Silva , Mergulhão Raelly Jeniffer da Silva 
Published: October 2022

A Sistematização da Assistência de Enfermagem Perioperatória, busca assegurar o planejamento da assistência de acordo com as necessidades individuais de cada paciente em condição pré, intra, e pós operatória e assegurar uma assistência integral, individualizada, com efetividade e devidamente registrada, a fim de elevar os padrões de assistência de enfermagem segura. Objetivo: Analisar o perfil epidemiológico dos pacientes submetidos à angioplastia coronária transluminal percutânea e avaliar a assistência de enfermagem para esse público. Método: A referida pesquisa trata-se de uma revisão integrativa de literatura. Resultados: Constatou-se a relevância que a SAEP possui na assistência aos pacientes submetidos a angioplastia coronária transluminal percutânea. Conclusão: A Sistematização da Assistência de Enfermagem Perioperatória garante o planejamento e o atendimento de forma integral, holística e individualizada, assegurando um maior bem estar e proteção aos clientes, contribuindo para uma melhor qualidade de vida pós intervenção coronária percutânea.
Estudo exploratório sobre a percepção e grau de informação de acadêmicas submetidas a inserção de prótese mamária
Authors: Major Beatriz Merlim Rodrigues , Amaral Valéria do , Paule Carlos Felipe Pasquini de 
Published: October 2022

A mamoplastia é a cirurgia plástica mais realizada em escala global, sendo intensamente estimulada pela extensa divulgação nas mídias sociais e pela alteração gradual dos padrões de beleza, que, atualmente, visam mamas com maior volume e projeção. No entanto, esse procedimento apresenta riscos de desfechos negativos, muitas vezes não informado às pacientes. O presente trabalho tem como objetivo coletar dados sobre a qualidade das informações dadas às pacientes submetidas à mamoplastia, com foco nas complicações que podem ocorrer no pós-operatório. O estudo foi realizado em duas fases: a primeira por meio de uma revisão de literatura com levantamento de dados científicos a partir de 2011 até 2022. A segunda fase se baseou na coleta de dados de pacientes que se submeteram ao procedimento cirúrgico, através de preenchimento de formulário online. A pesquisa teve 40 questionários reenviados aos pesquisadores, sendo que, deste montante, 17,5% (n = 7) tiveram que ser excluídos da análise. Dentre as entrevistadas, 33% não sabiam ou não receberam o Termo de Consentimento Livre e Esclarecido e 67% o receberam. Quanto aos veículos de informação consultados, os principais foram: cirurgião plástico (90%, n = 30), pessoas que realizaram a mesma cirurgia (85%, n = 28) e internet (70%, n = 23). Conclui-se os cirurgiões plásticos falharam em instruir corretamente as pacientes e em reforçar a importância da leitura ativa e atenta do Termo de Consentimento Livre e Esclarecido. Todavia, pode-se constatar que o procedimento impactou positivamente a qualidade de vida dessas mulheres.
Aproximación a la Arquitectura y el Urbanismo Huelva en los siglos IX-VI a.C.
Authors: Cano Pérez Alejandro , Toscano Pérez Clara , Bermejo Meléndez Javier 
Published: October 2022

El presente artículo tiene como propósito realizar una aproximación a la realidad arquitectónica y al fenómeno urbano desarrollado en la ciudad de Huelva entre los siglos VIII y VI a.C. Esta investigación parte de la consulta de los resultados de las diferentes intervenciones arqueológicas realizadas en lo que conocemos como la Zona Arqueológica de Huelva, destacando aquellas que han sido trascendentales para el desarrollo de esta línea de investigación.
Asimismo, para enriquecer y proporcionar nuevas perspectivas al estado de la investigación, hemos propuesto el SIG como herramienta de apoyo por su capacidad para interconectar, gestionar y analizar toda la información relativa a nuestro caso de estudio. Así como un nuevo medio por el cual difundir virtualmente el patrimonio protohistórico y punto de partida para avanzar en la investigación en el futuro.
Balanites aegyptiaca leaf extract-mediated synthesis of silver nanoparticles and their catalytic dye degradation and antifungal efficacy
Authors: Dhaka Anita , Raj Shani , Githala Chanda kumari , Chand Mali Suresh , Trivedi Rohini 
Published: October 2022

This study describes the biosynthesis of silver nanoparticles (AgNPs) using Balanites aegyptiaca (B. aegyptiaca) leaf extract. The biosynthesized AgNPs were characterized by UV-Vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), X-ray diffraction (XRD), Raman spectroscopy, transmission electron microscopy (TEM) and scanning electron microscopy with (SEM-EDS). The AgNPs showed an average size of 10–20 nm, spherical shape, and crystalline nature. The application of these synthesized AgNPs to dye degradation showed that the AgNPs removed the two organic pollutants methylene blue (MB, 93.47%) and congo red (CR, (78.57%). In vitro investigation of the antifungal activity of the AgNPs against Fusarium oxysporum, a phytopathogenic fungus, showed a maximum percent radial growth inhibition of 82.00 ± 1.00% and a spore percent inhibition of 73.66 ± 3.94 for 150 μg/ml of biosynthesized AgNPs.
Overrepresentation of Enterobacteriaceae and Escherichia coli is the major gut microbiome signature in Crohn’s disease and ulcerative colitis; a comprehensive metagenomic analysis of IBDMDB datasets
Authors: Khorsand Babak , Asadzadeh Aghdaei Hamid , Nazemalhosseini-Mojarad Ehsan , Nadalian Bahareh , Nadalian Banafsheh , Houri Hamidreza 
Published: October 2022

ObjectivesA number of converging strands of research suggest that the intestinal Enterobacteriaceae plays a crucial role in the development and progression of inflammatory bowel disease (IBD), however, the changes in the abundance of Enterobacteriaceae species and their related metabolic pathways in Crohn’s disease (CD) and ulcerative colitis (UC) compared to healthy people are not fully explained by comprehensive comparative metagenomics analysis. In the current study, we investigated the alternations of the Enterobacterales population in the gut microbiome of patients with CD and UC compared to healthy subjects.MethodsMetagenomic datasets were selected from the Integrative Human Microbiome Project (HMP2) through the Inflammatory Bowel Disease Multi’omics Database (IBDMDB). We performed metagenome-wide association studies on fecal samples from 191 CD patients, 132 UC patients, and 125 healthy controls (HCs). We used the metagenomics dataset to study bacterial community structure, relative abundance, differentially abundant bacteria, functional analysis, and Enterobacteriaceae-related biosynthetic pathways.ResultsCompared to the gut microbiome of HCs, six Enterobacteriaceae species were significantly elevated in both CD and UC patients, including Escherichia coli, Klebsiella variicola, Klebsiella quasipneumoniae, Klebsiella pneumoniae, Proteus mirabilis, Citrobacter freundii, and Citrobacter youngae, while Klebsiella oxytoca, Morganella morganii, and Citrobacter amalonaticus were uniquely differentially abundant and enriched in the CD cohort. Four species were uniquely differentially abundant and enriched in the UC cohort, including Citrobacter portucalensis, Citrobacter pasteurii, Citrobacter werkmanii, and Proteus hauseri. Our analysis also showed a dramatically increased abundance of E. coli in their intestinal bacterial community. Biosynthetic pathways of aerobactin siderophore, LPS, enterobacterial common antigen, nitrogen metabolism, and sulfur relay systems encoded by E. coli were significantly elevated in the CD samples compared to the HCs. Menaquinol biosynthetic pathways were associated with UC that belonged to K. pneumoniae strains.ConclusionsIn conclusion, compared with healthy people, the taxonomic and functional composition of intestinal bacteria in CD and UC patients was significantly shifted to Enterobacteriaceae species, mainly E. coli and Klebsiella species.
Hyperspectral cathodoluminescence, trace element, and U-Pb geochronological characterization of apatite from the Ernest Henry iron oxide copper-gold (IOCG) deposit, Cloncurry district, Queensland
Authors: Steadman Jeffrey A. , Goemann Karsten , Thompson Jay M. , MacRae Colin M. , Belousov Ivan , Hohl Max 
Published: October 2022

Hyperspectral cathodoluminescence (CL), geochemical, and geochronological characterization of a series of apatite-bearing samples from within and around the Ernest Henry IOCG deposit, NW Queensland, Australia, have revealed complex mineral parageneses and a spectrum of U-Pb ages that point to the effects of multiple geological processes. No two samples are identical, either in geochemistry or texture, despite their relative proximity to one another (all samples within 5 km from Ernest Henry). Hyperspectral CL maps reveal diverse internal textures and emissions ranging from near infrared (NIR) to near ultraviolet (UV) with a complex series of spectra in all samples, requiring the fitting more than 40 individual peaks (both sharp and broad) to capture the observed variability. Imaging analyses via LA-ICPMS show that apatite from the Ernest Henry district is enriched above background in a variety of trace elements, including Na, Mg, Al, Si, V, Mn, As, Sr, Y, the rare Earth elements (REEs), Pb, Th, and U. Samples outside the ore zone display chondrite-normalized REE profiles that are consistent with either a magmatic or hydrothermal origin, whereas ore zone apatite exhibits profiles that are decidedly hydrothermal in nature. Moreover, specific zones within ore zone apatite grains are very As-rich (up to 7 wt% As2O5), and the effect of such high As on the hyperspectral CL signature of these zones is a pronounced dampening of CL emission, regardless of REE concentrations. Uranium-Pb dating of the same samples (via LA-ICPMS) has yielded a diverse array of overlapping Mesoproterozoic ages ranging from 1,580 ± 34 Ma to 1,533 ± 61 Ma. These results correlate to published ages that constrain hydrothermal alteration in the Ernest Henry area, both before and during Cu-Au mineralization. Collectively, these data highlight the complexity of apatite studies at Ernest Henry, the broader Cloncurry district, and probably analogous terranes elsewhere. A combination of micro-scale methods such as those used in this study are shown to be essential for accurately deciphering geological information contained within petrogenetic indicator minerals.
Increased levels of serum adenosine deaminase and increased risk of diabetic peripheral neuropathy in type 2 diabetes
Authors: Yu Chao , Zhuang Lei , Xu Feng , Zhao Li-hua , Wang Xiao-hua , Wang Chun-hua , Ning Li-yan , Zhang Xiu-lin , Zhang Dong-mei , Wang Xue-qin , Su Jian-bin 
Published: October 2022

BackgroundIncreased serum adenosine deaminase (ADA) levels have been shown to be involved in metabolic abnormalities and immune disequilibrium, which may in turn contribute to inflammatory diseases. This study aimed to determine whether increased serum ADA levels are related to diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes (T2D).MethodsThis study was part of a series exploring the potential risks for DPN. All patients received DPN assessment based on neuropathic symptoms, neuropathic signs, and nerve conduction studies to calculate the compositeZscore of nerve latency, amplitude and conduction velocity (NCV). DPN was confirmed by both at least a presentation of neuropathic symptoms/signs and an abnormal nerve conduction index. Serum ADA levels were also synchronously detected.ResultsA total of 384 eligible patients with T2D were recruited for this study, and 24.5% (n=94) were determined to have DPN. Increases in serum ADA levels were closely associated with increases in compositeZscore of latency (β=0.263,t=5.273,p&lt;0.001) and decreases in compositeZscore of amplitude (β=–0.126,t=–2.352,p=0.019) and NCV (β=–0.201,t=–3.841,p&lt;0.001) after adjusting for other clinical covariates. Moreover, each 5 U/L increase in serum ADA levels was associated with a 1.781-fold increased adjusted odds ratio of having DPN (95% confidence interval: 1.271–2.495). Furthermore, the optimal cut-off value of serum ADA levels to discriminate DPN was ≥14.2 U/L (sensitivity=59.57%, specificity=75.52% and Youden index=0.351) after analysis by receiver operating characteristic curve.ConclusionsIncreased serum ADA levels may be a potential risk factor for DPN in patients with T2D.
Prevalence of arsenic contamination in rice and the potential health risks to the Bahamian population—A preliminary study
Authors: Watson Carlton , Gustave Williamson 
Published: October 2022

Rice is among the most important staple foods worldwide. However, the consumption of rice and rice-based food products poses a potential health risk since rice is a paddy crop that is well known to accumulate high concentrations of arsenic (As) in its grain. In The Bahamas, although rice is heavily consumed, it is not grown locally. Instead, all the consumed rice and its derived products are imported. Recent food surveys in the major rice exporting countries have shown that a significant portion of their market rice products is contaminated with As. However, to date, the prevalence of As in the rice foods available in The Bahamas remains unknown. Therefore, in this study, we surveyed the occurrence of As in a selection of rice and rice products that were on sale in the Bahamian market. A total of 21 different rice brands were collected. The concentration of As and the potential health risk were estimated by target hazard quotient (THQ), hazard index (HI), and lifetime cancer risk (LCR). Our results showed that only the blue ribbon samples had an estimated inorganic arsenic (iAs) concentration above the World Health Organization (WHO) safety limits (200 μg/kg), which is based on global average consumption. However, when we factor for average rice consumption in The Bahamas, 79% of the rice samples had iAs concentration values indicative of carcinogenic risks and 57% had iAs concentration values that suggested non-carcinogenic health risks. Based on our results, we recommend urgent follow-up studies to further test rice varieties that show the greatest LCR and HI values and to also broaden the study to include more off-brand/generic varieties, cooked rice, and drinking water.
Dual immunological and proliferative regulation of immune checkpoint FGL1 in lung adenocarcinoma: The pivotal role of the YY1–FGL1–MYH9 axis
Authors: Tang Xi-Yang , Xiong Yan-Lu , Zhao Ya-Bo , Yang Jie , Shi An-Ping , Zheng Kai-Fu , Liu Yu-Jian , Shu Chen , Jiang Tao , Ma Nan , Zhao Jin-Bo 
Published: October 2022

RationalLung cancer is the most common tumor worldwide, with the highest mortality rate and second highest incidence. Immunotherapy is one of the most important treatments for lung adenocarcinoma (LUAD); however, it has relatively low response rate and high incidence of adverse events. Herein, we explored the therapeutic potential of fibrinogen-like protein 1 (FGL1) for LUAD.MethodsData from GEPIA and ACLBI databases were assessed to explore gene–gene correlations and tumor immune infiltration patterns. A total of 200 patients with LUAD were recruited. FGL1 levels in the serum and cellular supernatant were determined by enzyme-linked immunosorbent assay. In vitro and in vivo experiments were performed to assess the effect FGL1 on the proliferation of LUAD cells. Cocultures were performed to explore the effect of FGL1 knockdown in lung cancer cells on T cells, concerning cytokine secretion and viability. PROMO and hTFtarget databases were used for transcription factor prediction. Quantitative polymerase chain reaction (qPCR), chromatin immunoprecipitation, and dual luciferase reporter assays were performed to validate the identified transcription factor of FGL1. Immunoprecipitation, mass spectrometry and gene ontology analysis were performed to explore the downstream partners of FGL1.ResultsFGL1 expression in LUAD was positively associated with PDL1, but not for PD1 expression. Moreover, FGL1 was positively associated with the CD3D expression and negatively associated with FOXP3, S100A9, and TPSB2 within the tumor site. FGL1 promotes the secretion of interleukin-2 by T cells in vitro, simultaneously inducing their apoptosis. Indeed, YY1 is the upstream molecule of FGL1 was found to be transcriptionally regulated by YY1 and to directly by to MYH9 to promote the proliferation of LUAD cells in vitro and in vivo.ConclusionsFGL1 is involved in the immunological and proliferative regulation of LUAD cells by controlling the secretion of important immune-related cytokines via the YY1–FGL1–MYH9 axis. Hence, targeting FGL1 in LUAD may pave the way for the development of new immunotherapies for tackling this malignancy.
Investigation on the grain size effect on the copper shaped charge jet stretching behavior
Authors: Jiang Yao , Gu Rui Cong , Wang Jing Tao , Xiao Qiang-Qiang , Huang Zheng-Xiang 
Published: October 2022

The grain size effect on the shaped charge jet (SCJ) stretching process was analytically formulated and experimentally verified by penetration tests. The present analytical model predicts an optimum grain size for the SCJ performance, deduced from the concurrent effect of grain size on flow stress, strain rate sensitivity, and surface roughness. Specifically, reducing the grain size will improve the initial surface roughness and decrease the initial perturbation amplitude, favoring the SCJ stretching. On the other hand, the strain rate sensitivity and flow stress for copper increase with the decrease of grain size, facilitating the perturbation growth and leading to a premature breakup. Thus, the present analytical model predicts that the optimum grain size of the SCJ is about 1–5 μm. The penetration test verified that the shaped charge liner with an average grain size of about 3.6 ± 2.5 μm exhibited the largest penetration depth. The consistent results from the analytical model and the penetration experiments certify the feasibility of the present analytical model on the SCJ performance.
Effectiveness of acupuncture combined with rehabilitation training vs. rehabilitation training alone for post-stroke shoulder pain: A systematic review and meta-analysis of randomized controlled trials
Authors: Zhan Jie , Wei Xiaojing , Tao Chenyang , Yan Xiaoting , Zhang Peiming , Chen Rouhao , Dong Yu , Chen Hongxia , Liu Jianhua , Lu Liming 
Published: October 2022

BackgroundPost-stroke shoulder pain (PSSP) is characterized by shoulder pain on the hemiplegic side, which can limit physical activity in patients with stroke. Acupuncture combined with rehabilitation training (AR) has been widely used in PSSP, but the evidence of its effectiveness is still unclear.ObjectiveThe study aimed to evaluate the effect and safety of AR vs. rehabilitation training (RT) alone on PSSP.MethodsWe searched PubMed, the Cochrane Library, the Chinese Biological Medicine Database (CBM), the Chinese Scientific Journal Database (VIP), China National Knowledge Infrastructure (CNKI), and the WAN FANG database for relevant studies from their inception to February 2022. Only randomized controlled trials (RCTs) comparing the effect of AR with RT alone on PSSP were considered. The primary outcome was shoulder pain. Secondary outcomes included upper limb motor function, activities of daily living (ADL), shoulder range of motion (ROM), and adverse events (AEs). Subgroup analysis and sensitivity analysis were also conducted. Quality assessment was implemented based on Cochrane risk of bias (ROB) criteria, which consist of seven items. When more than four items in a study were judged as low ROB, the overall quality of this study was considered low risk.ResultsA total of 40 studies were included in the qualitative analysis, and 35 (87.5%) studies with 2,554 patients were included in the meta-analysis. Of the 40 studies, 14 (35.0%) were of moderate-to-high quality. The meta-analysis results showed that AR is better than RT alone in reducing shoulder pain (MD −1.32, 95% CI −1.58 to −1.07), improving upper limb motor function (MD 6.81, 95% CI 4.95–8.67), ADL (MD 11.17, 95% CI 9.44–12.91), and shoulder ROM (internal rotation: MD 10.48, 95% CI 8.14–12.83; backward extension: MD 7.82, 95% CI 6.00–9.64; anteflexion: MD 12.88, 95% CI 5.47–20.29; external rotation: MD 11.40, 95% CI 6.17–16.64; abduction: MD 16.96, 95% CI 8.61–25.31) without obvious AEs.ConclusionAR may be better than RT alone for the improvement of shoulder pain, upper limb motor function, ADL, and shoulder ROM, without obvious AEs in patients with PSSP. However, considering the clinical and statistical heterogeneity, our findings need to be interpreted with caution. More rigorous RCTs in this area should be conducted in the future.Systematic review registration[www.crd.york.ac.uk], identifier [CRD42022326763].
Prospective pilot study of tirofiban in progressive stroke after intravenous thrombolysis
Authors: Zhang Yan , Wang Jianliang , Ma Zhaoxi , Mu Guihua , Liang Da , Li Yifan , Qian Xiaoyan , Zhang Luyuan , Shen Fang , Zhang Lei , Yu Jie , Liu Yang 
Published: October 2022

BackgroundIntravenous thrombolysis (IVT) is a standard procedure for the treatment of patients with acute ischemic stroke (AIS). Improving the therapeutic efficacy of IVT is an important task for neurologists. The aim of this study was to evaluate the efficacy and safety of early low-dose tirofiban treatment in AIS patients with early neurological deterioration (END) after IVT.MethodsIn this prospective and randomized pilot study, 73 AIS patients with END were recruited from a local hospital in China. Of these, 14 patients were treated with regular antiplatelet agents (aspirin plus clopidogrel) and 59 patients were treated with tirofiban within 24 h of IVT, followed by regular antiplatelet therapy. Neurological deficits and functional recovery were assessed with NIHSS and modified Rankin Scale (mRS) at 7 and 90 days. During the 90-day follow-up period, both hemorrhagic (e.g., intracerebral hemorrhage) and non-hemorrhagic (e.g., pneumonia) events were recorded.ResultsTreatment with tirofiban compared with regular antiplatelet therapy: (1) improved functional recovery of AIS patients to mRS (≤2) at both 7 and 90 days (odds ratios [ORs], 1.37 and 1.64; 95% confidence interval [CI], 1.16–1.61 and 1.26–2.12; P = 0.008 and &lt; 0.001, respectively), and (2) reduced NIHSS scores from 11.14 ± 2.38 to 5.95 ± 3.48 at day 7 (P &lt; 0.001) and from 8.14 ± 2.74 to 4.08 ± 3.50 at day 90 (P &lt; 0.001). Tirofiban treatment did not increase the risk of hemorrhagic complications. Multivariate regression analysis showed that tirofiban treatment independently predicted a favorable functional outcome (P ≤ 0.001).ConclusionEarly treatment with low-dose tirofiban in AIS patients with neurologic deterioration after IVT potentially improved functional recovery and attenuated neurologic deficits as early as 7 days and did not increase the risk of various hemorrhagic complications. However, the therapeutic efficacy of tirofiban treatment in END patients needs to be determined by future randomized clinical trials with a large study population.Clinical trial registrationhttp://www.chictr.org.cn/, Identifier ChiCTR2200058513.