bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stakeholder Green Pressure and New Product Performance in Emerging Countries: A Cross‐country Study
Authors: Adomako Samuel , Simms Chris , Vazquez‐Brust Diego , Nguyen Hang T.T. 
Published: February 2022

AbstractDespite the burgeoning literature on stakeholder green pressure, research is scarce on how it influences eco‐product innovation and new product performance. This article examines stakeholder green pressures as antecedents of eco‐product innovation and new product performance in firms operating in resource‐constrained countries. Using data gathered from surveys in Vietnam (N = 183) and Ghana (N = 217), we find that the positive effects of stakeholder green pressures on new product performance are serially mediated by environmental sustainability orientation and eco‐product innovation. Our findings contribute to ongoing efforts to clarify the mechanisms channelling stakeholder pressures into new product performance in resource‐constrained environments.
Aberrant arrangement of the musculocutaneous and median nerves in the thoracic limbs of a mixed‐breed dog cadaver
Authors: Kamali Younes 
Published: February 2022

AbstractIn the left thoracic limb of a male cadaver (adult mixed‐breed dog), the median nerve (MN) after departing from the common median/ulnar nerve (UN) trunk received two branches. One from the lateral thoracic nerve (LTN) and the other from the musculocutaneous nerve (MCN). These both passed cranial to the axillary artery at the level of the lateral thoracic artery and joined the median nerve. Thus, in the proximal brachium, the axillary artery was cradled by this union, similar to the ansa axillaris of large animals and similar formations reported in human and non‐human primates. In the distal brachium, the communicating branch ran unusually from the MN to the MCN on the left, and in both directions on the right. Awareness of such anatomical variations of the terminal branches of the brachial plexus (BP) in addition to the embryonic and evolutionary aspects can be useful in explaining neuroarterial signs with unknown origin, as those reported in human medicine.
Willingness to accept risk with medication in return for cure of symptoms among patients with Rome IV irritable bowel syndrome
Authors: Goodoory Vivek C. , Ng Cho Ee , Black Christopher J. , Ford Alexander C. 
Published: February 2022

SummaryBackgroundSome drugs for irritable bowel syndrome (IBS) have serious side effects.AimsTo examine the willingness of individuals with IBS to accept risks with medication in return for symptom cure.MethodsWe collected demographic, gastrointestinal symptoms, psychological health, quality of life and impact on work and daily activities data from 752 adults with Rome IV‐defined IBS. We examined median willingness to accept death in return for cure with a hypothetical medication using a standard gamble, according to these variables.ResultsParticipants would accept a median 2.0% (IQR 0.0%‐9.0%) risk of death in return for a 98.0% (IQR 91.0%‐100.0%) chance of permanent symptom cure. The median accepted risk of death was higher in men (5.0% vs 2.0%, P < 0.001), those with continuous abdominal pain (4.0% vs 1.0%, P < 0.001), more severe symptoms (P = 0.005 for trend), abnormal depression scores (P < 0.001 for trend), higher gastrointestinal symptom‐specific anxiety (P < 0.001 for trend), and lower IBS‐related quality of life (P < 0.001 for trend). Those willing to accept above median risk of death were more likely to be male (17.1% vs 9.1%, P < 0.001), take higher levels of risks in their daily life (P = 0.008 for trend), and report continuous abdominal pain (53.1% vs 39.4%, P < 0.001), and had higher depression (P = 0.004 for trend) and lower quality of life (P < 0.001 for trend) scores.ConclusionPatients are willing to accept significant risks in return for cure of their IBS symptoms.
The behavioural and physiological ecology of embryos: responding to the challenges of life inside an egg
Authors: Du Wei‐Guo , Shine Richard 
Published: February 2022

ABSTRACTAdaptations of post‐hatching animals have attracted far more study than have embryonic responses to environmental challenges, but recent research suggests that we have underestimated the complexity and flexibility of embryos. We advocate a dynamic view of embryos as organisms capable of responding – on both ecological and evolutionary timescales – to their developmental environments. By viewing embryos in this way, rather than assuming an inability of pre‐hatching stages to adapt and respond, we can broaden the ontogenetic breadth of evolutionary and ecological research. Both biotic and abiotic factors affect embryogenesis, and embryos exhibit a broad range of behavioural and physiological responses that enable them to deal with changes in their developmental environments in the course of interactions with their parents, with other embryos, with predators, and with the physical environment. Such plasticity may profoundly affect offspring phenotypes and fitness, and in turn influence the temporal and spatial dynamics of populations and communities. Future research in this field could benefit from an integrated framework that combines multiple approaches (field investigations, manipulative experiments, ecological modelling) to clarify the mechanisms and consequences of embryonic adaptations and plasticity.
Category Clustering and Morphological Learning
Authors: Mansfield John , Saldana Carmen , Hurst Peter , Nordlinger Rachel , Stoll Sabine , Bickel Balthasar , Perfors Andrew 
Published: February 2022

AbstractInflectional affixes expressing the same grammatical category (e.g., subject agreement) tend to appear in the same morphological position in the word. We hypothesize that this cross‐linguistic tendency towardcategory clusteringis at least partly the result of a learning bias, which facilitates the transmission of morphology from one generation to the next if each inflectional category has a consistent morphological position. We test this in an online artificial language experiment, teaching adult English speakers a miniature language consisting of noun stems representing shapes and suffixes representing the color and number features of each shape. In one experimental condition, each suffix category has a fixed position, with color in the first position and number in the second position. In a second condition, each specific combination of suffixes has a fixed order, but some combinations have color in the first position, and some have number in the first position. In a third condition, suffixes are randomly ordered on each presentation. While the language in the first condition is consistent with the category clustering principle, those in the other conditions are not. Our results indicate that category clustering of inflectional affixes facilitates morphological learning, at least in adult English speakers. Moreover, we found that languages that violate category clustering but still follow fixed affix ordering patterns are more learnable than languages with random ordering. Altogether, our results provide evidence for individual biases toward category clustering; we suggest that this bias may play a causal role in shaping the typological regularities in affix order we find in natural language.
Effect of mitochondrial‐targeted antioxidants on glycaemic control, cardiovascular health, and oxidative stress in humans: A systematic review and meta‐analysis of randomized controlled trials
Authors: Mason Shaun Andrew , Wadley Glenn David , Keske Michelle Anne , Parker Lewan 
Published: February 2022

AbstractAimTo investigate the effects of mitochondrial‐targeted antioxidants (mitoAOXs) on glycaemic control, cardiovascular health, and oxidative stress outcomes in humans.Materials and MethodsRandomized controlled trials investigating mitoAOX interventions in humans were searched for in databases (MEDLINE‐PubMed, Scopus, EMBASE and Cochrane Library) and clinical trial registries up to 10 June 2021. The Cochrane Collaboration's tool for assessing risk of bias and Grading of Recommendations, Assessment, Development and Evaluations were used to assess trial quality and evidence certainty, respectively.ResultsNineteen studies (n = 884 participants) using mitoAOXs (including Elamipretide, MitoQ and MitoTEMPO) were included in the systematic review. There were limited studies investigating the effects of mitoAOXs on glycaemic control; and outcomes and population groups in studies focusing on cardiovascular health were diverse. MitoAOXs significantly improved brachial flow‐mediated dilation (n = 3 trials; standardized mean difference: 1.19, 95% CI: 0.28, 2.16; I2: 67%) with very low evidence certainty. No significant effects were found for any other glycaemic, cardiovascular or oxidative stress‐related outcomes with mitoAOXs in quantitative analyses, with evidence certainty rated mostly as low. There was a lack of serious treatment‐emergent adverse events with mitoAOXs, although subcutaneous injection of Elamipretide increased mild–moderate injection site‐related events.ConclusionWhile short‐term studies indicate that mitoAOXs are generally well tolerated, there is currently limited evidence to support the use of mitoAOXs in the management of glycaemic control and cardiovascular health. Review findings suggest that future research should focus on the effects of mitoAOXs on glycaemic control and endothelial function in target clinical population groups.
Surgical outcome of temporal plus epilepsy is improved by multilobar resection
Authors: Barba Carmen , Rheims Sylvain , Minotti Lorella , Grisotto Laura , Chabardès Stéphan , Guenot Marc , Isnard Jean , Pellacani Simona , Hermier Marc , Ryvlin Philippe , Kahane Philippe 
Published: February 2022

AbstractObjectiveTemporal plus epilepsy (TPE) represents a rare type of epilepsy characterized by a complex epileptogenic zone including the temporal lobe and the close neighboring structures. We investigated whether the complete resection of temporal plus epileptogenic zone as defined through stereoelectroencephalography (SEEG) might improve seizure outcome in 38 patients with TPE.MethodsInclusion criteria were as follows: epilepsy surgery performed between January 1990 and December 2001, SEEG defining a temporal plus epileptogenic zone, unilobar temporal operations (“temporal lobe epilepsy [TLE] surgery”) or multilobar interventions including the temporal lobe (“TPE surgery”), magnetic resonance imaging either normal or showing signs of hippocampal sclerosis, and postoperative follow‐up of at least 12 months. For each assessment of postoperative seizure outcome, at 1, 2, 5, and 10 years, we carried out descriptive analysis and classical tests of hypothesis, namely, Pearson χ2test or Fisher exact test of independence on tables of frequency for each categorical variable of interest and Studentt‐test for each continuous variable of interest, when appropriate.ResultsTwenty‐one patients underwent TPE surgery and 17 underwent TLE surgery with a follow‐up of 12.4 ± 8.16 years. In the multivariate models, there was a significant effect of the time from surgery on Engel Class IA versus IB–IV outcome, with a steadily worsening trend from 5‐year follow‐up onward. TPE surgery was associated with better results than TLE surgery.SignificanceThis study suggests that surgical outcome in patients with TPE can be improved by a tailored, multilobar resection and confirms that SEEG is mandatory when a TPE is suspected.
Genetic assignment of fisheries bycatch reveals disproportionate mortality among Alaska Northern Fulmar breeding colonies
Authors: Baetscher Diana S. , Beck Jessie , Anderson Eric C. , Ruegg Kristen , Ramey Andrew M. , Hatch Scott , Nevins Hannah , Fitzgerald Shannon M. , Carlos Garza John 
Published: February 2022

AbstractGlobal fisheries kill millions of seabirds annually through bycatch, but little is known about population‐level impacts, particularly in species that form metapopulations. U.S. North Pacific groundfish fisheries catch thousands of Northern Fulmars (Fulmarus glacialis rodgersii) each year, making fulmars the most frequently caught seabird in federally managed U.S. fisheries. Here, we used genetic stock identification to assign 1,536 fulmars sampled as bycatch to one of four Alaska breeding colonies and quantified the similarity of bycatch locations at sea among colonies. We found disproportionately high bycatch from the Pribilof Islands (6% of metapopulation, 23% of bycatch), and disproportionately low bycatch from Chagulak Island (34% of metapopulation, 14% of bycatch). Overlap between fisheries and colony‐specific foraging areas diverge more during the summer breeding season, leading to greater differences in bycatch susceptibility. Contemporary and historical gene flow likely contributes to low genetic differentiation among colonies (FST = 0.003–0.01), yet these values may not represent present connectivity. Our findings illustrate how genetic stock identification can link at‐sea threats to colonies and inform management to reduce bycatch from impacted colonies.
Fermentation reduced the in vitro glycemic index values of probiotic‐rich bean powders
Authors: Tao Li , Song Shixin , Liu Chang , Huang Wanru , Bi Yunfeng , Yu Lei 
Published: February 2022

SummaryThe effects of fermentation on the in vitro estimated glycemic index (eGI) values of probiotic‐rich bean powders were investigated. The main nutrients in the probiotic‐rich bean powders after fermentation were not significantly reduced. The results showed that fermentation led to the reduction of the eGI values of bean powder in experiments with in vitro digestion. It was considered to correlate positively with the increase of resistant starch percentage, the decrease of the starch hydrolysis index, the inhibition of α‐amylase and α‐glucosidase activities, the increase of the phenolic compounds, and the enhancement of the total antioxidant capacity in bean powders after fermentation. That was beneficial to human health.
Enhanced thermal stability of soy protein particles by a combined treatment of microfluidic homogenisation and preheating
Authors: Ren Chao , Zheng Xiaohan , Zou Bowen , Wang Jiamei , Xu Xianbing , Wu Chao , Du Ming 
Published: February 2022

AbstractRecently, the pursuit of having a healthy diet has heightened the superiority of protein‐enriched beverages; however, this is challenged by the heat‐induced aggregation and gelation of proteins at high concentration. In this study, a facile and efficient strategy of combined preheating and microfluidic homogenisation treatment (CPMHT) was tested to enhance the heat stability of soy proteins (SPs). Results revealed that the CPMHT promoted the denaturation and unfolding of SPs, evidenced by the reduction of β‐sheet content and a slight red shift of fluorescence intensity. Increasing the number of CPMHT cycle led to an apparent decrease in the surface hydrophobicity and total sulfhydryl groups of soy proteins. In addition, when the suspensions (10% (w/v)) of modified soy proteins at higher CPMHT cycle were reheated at 100 °C for 30 min, no gelation was found, along with lower viscosities and higher flow behaviour index. The present study provides an approaching to enhance the heat stability of soy proteins by CPMHT, which might expand the application of soy proteins in protein‐enriched beverages.
New‐onset fulminant type 1 diabetes after severe acute respiratory syndrome coronavirus 2 vaccination: A case report
Authors: Sasaki Keyaki , Morioka Tomoaki , Okada Natsumi , Natsuki Yuka , Kakutani Yoshinori , Ochi Akinobu , Yamazaki Yuko , Shoji Tetsuo , Ohmura Takashi , Emoto Masanori 
Published: February 2022

AbstractFulminant type 1 diabetes is characterized by a rapid progression of insulin deficiency triggered by viral infection. Here, we report a case of a 45‐year‐old Japanese woman with fulminant type 1 diabetes that developed 8 days after receiving messenger ribonucleic acid vaccine against severe acute respiratory syndrome coronavirus 2. She had been healthy and had no symptoms suggestive of viral infection before the vaccination. Laboratory tests showed exhaustion of insulin secretion and negative results for islet autoantibodies. Human leukocyte antigen genotype analysis showed the DRB1*04:05 and DQB1*04:01 alleles. This is the first case report of new‐onset fulminant type 1 diabetes after severe acute respiratory syndrome coronavirus 2 vaccination, and suggests that a severe acute respiratory syndrome coronavirus 2 vaccine might trigger the onset of fulminant type 1 diabetes in susceptible individuals. However, a causal relationship remains to be identified, and further studies are required to determine the incidence of such cases.
Worry about COVID‐19 as a predictor of future insomnia
Authors: Brown Lily A. , Hamlett Gabriella E. , Zhu Yiqin , Wiley Joshua F. , Moore Tyler M. , DiDomenico Grace E. , Visoki Elina , Greenberg David M. , Gur Ruben C. , Gur Raquel E. , Barzilay Ran 
Published: February 2022

SummaryThe coronavirus disease 2019 (COVID‐19) pandemic resulted in significant increases in insomnia, with up to 60% of people reporting increased insomnia. However, it is unclear whether exposure to risk factors for the virus or worries about COVID‐19 are more strongly associated with insomnia. Using a three‐part survey over the course of the first 6 months of the pandemic, we evaluated associations between COVID‐19 exposures, COVID‐19 worries, and insomnia. We hypothesised that COVID‐19‐related worries and exposure to risk of COVID‐19 would predict increases in insomnia. Participants (N = 3,560) completed a survey at three time‐points indicating their exposures to COVID‐19 risk factors, COVID‐19‐related worries, and insomnia. COVID‐19 worry variables were consistently associated with greater insomnia severity, whereas COVID‐19 exposure variables were not. COVID‐19 worries decreased significantly over time, and there were significant interactions between change in COVID‐19 worries and change in insomnia severity over time. Individuals who experienced increases in COVID‐19 worries also experienced increases in insomnia severity. Changes in worry during the COVID‐19 pandemic were associated with changes in insomnia; worries about COVID‐19 were a more consistent predictor of insomnia than COVID‐19 exposures. Evidence‐based treatments targeting virus‐related worries may improve insomnia during this and future calamities.
Examining Deductive Versus Guided Instruction From an Interactionist Perspective
Authors: Azkarai Agurtzane , Oliver Rhonda , Gil‐Berrio Yohana 
Published: February 2022

AbstractThe interactionist hypothesis holds that conversational interaction facilitates second language (L2) learning by providing learners opportunities to receive meaningful input, modify their output, and attend to language form. Although research has often explored the efficacy of different types of L2 instruction (deductive or inductive), few studies have done so from an interactionist perspective. This study explores small‐group interactions of 19 L2 Spanish learners from two intact high school classes as they completed four communicative tasks following either deductive or PACE instruction on the pronoun se. We examined the nature of the student group interactions in each class, focusing on negotiation of meaning (NoM) strategies and language‐related episodes (LREs). The deductive participants used more NoM strategies, and produced more LREs than PACE participants. Regardless of the type of instruction, the majority of LREs dealt with vocabulary and were resolved correctly. Task conditions also mediated the outcomes of feedback and LREs.
A data‐free, support vector machine‐based physics‐driven estimator for dynamic response computation
Authors: Luo Huan , Paal Stephanie German 
Published: February 2022

AbstractDirect integration methods are widely used for dynamic response computation. However, the performance of their computational accuracy significantly degrades with increasing the time step. Although machine learning methods can address this shortcoming, they require training data for dynamic response computation. This paper proposes a novel computational method to overcome these shortcomings. The proposed approach is a data‐free physics‐driven estimator, which minimizes the objective function of multi‐output least squares support vector machines for regression to model parameters subject to physical constraints introduced by the multi‐degree of freedom system's dynamic equilibrium equations and initial conditions in the feature space, bypassing the need for training data (due to the coupled physics) and for satisfying the requirement of the time step due to the built‐in optimization procedure. A new efficient step‐by‐step solver is developed to solve the optimization problem, and the solution is equivalent to a hyperplane satisfying the physical constraints in the feature space. The extension of the proposed approach for nonlinear dynamic response computation is also analyzed theoretically. The numerical results demonstrate that the proposed approach provides the solution with higher accuracy and efficiency and achieves the best performance for large time steps over classical integration methods.
CsMYB1 integrates the regulation of trichome development and catechins biosynthesis in tea plant domestication
Authors: Li Penghui , Fu Jiamin , Xu Yujie , Shen Yihua , Zhang Yanrui , Ye Zhili , Tong Wei , Zeng Xiangsheng , Yang Jihong , Tang Dingkun , Li Ping , Zuo Hao , Wu Qiong , Xia Enhua , Wang Shucai , Zhao Jian 
Published: February 2022

Summary

Tea trichomes synthesize numerous specialized metabolites to protect plants from environmental stresses and contribute to tea flavours, but little is known about the regulation of trichome development.

Here, we showed that CsMYB1 is involved in the regulation of trichome formation and galloylated cis‐catechins biosynthesis in tea plants. The variations in CsMYB1 expression levels are closely correlated with trichome indexes and galloylated cis‐catechins contents in tea plant populations. Genome resequencing showed that CsMYB1 may be selected in modern tea cultivars, since a 192‐bp insertion in CsMYB1 promoter was found exclusively in modern tea cultivars but not in the glabrous wild tea Camellia taliensis. Several enhancers in the 192‐bp insertion increased CsMYB1 transcription in modern tea cultivars that coincided with their higher galloylated cis‐catechins contents and trichome indexes.

Biochemical analyses and transgenic data showed that CsMYB1 interacted with CsGL3 and CsWD40 and formed a MYB‐bHLH‐WD40 (MBW) transcriptional complex to activate the trichome regulator genes CsGL2 and CsCPC, and the galloylated cis‐catechins biosynthesis genes anthocyanidin reductase and serine carboxypeptidase‐like 1A. CsMYB1 integratively regulated trichome formation and galloylated cis‐catechins biosynthesis.

Results suggest that CsMYB1, trichome and galloylated cis‐catechins are coincidently selected during tea domestication by harsh environments for improved adaption and by breeders for better tea flavours.