bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonlinear autocorrelation function of functional time series
Authors: Huang Xin , Shang Han Lin 
Published: October 2022

AbstractIn functional time series analysis, the functional autocorrelation function (fACF) plays an important role in revealing the temporal dependence structures underlying the dynamics and identifying the lags at which substantial correlation exists. However, akin to its counterpart in the univariate case, the fACF is restricted by linear structure and can be misleading in reflecting nonlinear temporal dependence. This paper proposes a nonlinear alternative to the fACF for analyzing the temporal dependence in functional time series. We consider linear and nonlinear data generating processes: a functional autoregressive process and a functional generalized autoregressive conditional heteroskedasticity process. We demonstrate that when the process exhibits linear temporal structures, the inference obtained from our proposed nonlinear fACF is consistent with that from the fACF. When the underlying process exhibits nonlinear temporal dependence, our nonlinear fACF has a superior capability in uncovering the nonlinear structure that the fACF misleads. An empirical data analysis highlights its applications in unveiling nonlinear temporal structures in the daily curves of the intraday volatility dynamics of the foreign exchange rate.
On the dynamics between local and international tax planning in multinational corporations
Authors: Beuselinck Christof , Pierk Jochen 
Published: October 2022

AbstractThe international dimension of multinational corporations creates opportunities for pursuing both global as well as local (i.e., unilateral subsidiary country) tax planning strategies. To date, however, researchers have limited insights into both the dynamics and relative importance of one versus another strategy for multinationals. We propose and test a group-level ETR-based measure of profit shifting and validate it by showing it correctly identifies profit shifting reductions when shifting costs increase. We confirm that multinationals can keep group ETRs stable after the introduction of tighter tax compliance and documentation rules and suggest they can do so by relying relatively more on local tax planning. In line with the substitution argument, we document that especially groups identified as ex-ante income shifters as well as those with greater target ETR pressure are responsible for the results.
The Content of Cd and Pb in Herbs and Single-Component Spices Used in Polish Cuisine
Authors: Winiarska-Mieczan Anna , Jachimowicz Karolina , Kwiecień Małgorzata , Krusiński Robert , Kislova Svitlana , Sowińska Lesya , Zasadna Zvenyslava , Yanovych Dmytro 
Published: October 2022

AbstractSpices and herbs play an important role in the human diet, mostly due to the presence of essential oils and high antioxidant activity. Therefore, the toxicity of metals raises concerns about the safety of consumption of spices and herbs. This paper examines the content of Cd and Pb in fresh and dried herbs and single-component spices that are the most popular in Polish cuisine: 100 samples of nine kinds of dried herbs, 184 samples of 15 kinds of fresh herbs and 148 samples of 14 kinds of loose single-component spices. The level of Cd and Pb was determined using the GF AAS method. The safety of herbs and spices for consumption was estimated based on the percentage intake of Cd and Pb compared with the tolerable intake (% TWI, % BMDL), chronic daily intake (CDI), target hazard quotient (THQ), hazard index (HI) and comparisons of the results of chemical analyses with the maximum admissible levels of Cd and Pb in Poland and in the European Union. Calculated per fresh weight of the product, dried herbs on average contained 0.134 ± 0.168 mg of Cd and 0.548 ± 0.161 mg of Pb per kg−1, fresh herbs on average contained 0.004 ± 0.007 mg of Cd and 0.039 ± 0.033 mg of Pb per kg−1, and the mean content of Cd in spices was 0.017 ± 0.019 mg per kg−1 and 0.064 ± 0.050 mg of Pb. The % TWI, % BMDL, CDI, THQ and HI (Cd + Pb) for all the analysed products were lower than 1. The results do not imply a risk due to the supply of Cd and Pb with the diet to the human body, primarily due to the small intake of these products. However, it should be highlighted that the content of Cd in dried coriander and estragon and that of Pb in watercress, jiaogulan, celery, basil and dill exceeded the acceptable limit. Thus, their consumption for people from particularly sensitive groups such as babies, pregnant and breastfeeding women and people should be carefully limited.
HIV peripheral neuropathy‐related degeneration of white matter tracts to sensorimotor cortex
Authors: Timtim Sara H. , Simmons Alan N. , Hays Chelsea , Strigo Irina , Sorg Scott , Ellis Ronald , Keltner John R. 
Published: October 2022

AbstractHuman immunodeficiency virus-associated distal sensory polyneuropathy (HIV-DSP) affects up to 50% of people with HIV and is associated with depression, unemployment, and generally worsened quality of life. Previous work on the cortical mechanism of HIV neuropathy found decreased gray matter volume in the bilateral midbrain, thalamus, and posterior cingulate cortex, but structural connectivity in this context remains under-studied. Here we examine alterations in white matter microstructure using diffusion imaging, hypothesizing that cortical white matter degeneration would be observed in continuation of the peripheral white matter atrophy previously observed in HIV-DSP. Male HIV seropositive patients (n = 57) experiencing varying degrees of HIV neuropathy underwent single-shell diffusion tensor imaging with 51 sampling directions. The scans were pooled using tractography and connectometry to create a quantitative map of white matter tract integrity, measured in generalized fractional anisotropy (GFA). The relationship between GFA and neuropathy severity was evaluated with linear regression. Correction for multiple comparisons was done using false discovery rate (FDR), a statistical method commonly used in genomics and imaging to minimize false positives when thousands of individual comparisons are made. Neuropathy severity was associated with decreased GFA along thalamocortical radiations leading along the lateral thalamus to sensorimotor cortex, with r = -0.405 (p < 0.001; FDR), as well as with the superior bilateral cingulum (r = -0.346 (p < 0.05; FDR)). Among a population of HIV neuropathy patients, greater neuropathy severity was correlated with lower white matter integrity running from midbrain to somatosensory cortex. This suggests ascending deafferentation extending from damaged peripheral nerves further downstream than seen previously, into the axons of third-order neurons. There is also evidence of cingulum degeneration, implying some more complex mechanism beyond the ascending atrophy observed here.
The Impact of Subsidies on Persistent and Transient Technical Inefficiency: Evidence from Polish Dairy Farms
Authors: Pisulewski Andrzej , Marzec Jerzy 
Published: October 2022

AbstractWe investigate the impact of five types of subsidies granted under the European Union Common Agricultural Policy on the persistent and transient inefficiency of Polish dairy farms. Our research shows that coupled and environmental subsidies reduce transient technical inefficiency, while the opposite is true for Less Favoured Areas (LFA) and other rural subsidies. Simultaneously, environmental, LFA, and other rural subsidies increase persistent technical inefficiency. These results imply that the impact of each type of subsidy on technical efficiency can be different and that the effect of the particular type of subsidy can vary between transient and persistent technical inefficiency.
Change-Point Detection and Regularization in Time Series Cross-Sectional Data Analysis
Authors: Park Jong Hee , Yamauchi Soichiro 
Published: October 2022

AbstractResearchers of time series cross-sectional data regularly face the change-point problem, which requires them to discern between significant parametric shifts that can be deemed structural changes and minor parametric shifts that must be considered noise. In this paper, we develop a general Bayesian method for change-point detection in high-dimensional data and present its application in the context of the fixed-effect model. Our proposed method, hidden Markov Bayesian bridge model, jointly estimates high-dimensional regime-specific parameters and hidden regime transitions in a unified way. We apply our method to Alvarez, Garrett, and Lange’s (1991,American Political Science Review85, 539–556) study of the relationship between government partisanship and economic growth and Allee and Scalera’s (2012,International Organization66, 243–276) study of membership effects in international organizations. In both applications, we found that the proposed method successfully identify substantively meaningful temporal heterogeneity in parameters of regression models.
NCodR: A multi-class support vector machine classification to distinguish non-coding RNAs in Viridiplantae
Authors: Nithin Chandran , Mukherjee Sunandan , Basak Jolly , Bahadur Ranjit Prasad 
Published: October 2022

Abstract
Non-coding RNAs (ncRNAs) are major players in the regulation of gene expression. This study analyses seven classes of ncRNAs in plants using sequence and secondary structure-based RNA folding measures. We observe distinct regions in the distribution of AU content along with overlapping regions for different ncRNA classes. Additionally, we find similar averages for minimum folding energy index across various ncRNAs classes except for pre-miRNAs and lncRNAs. Various RNA folding measures show similar trends among the different ncRNA classes except for pre-miRNAs and lncRNAs. We observe different k-mer repeat signatures of length three among various ncRNA classes. However, in pre-miRs and lncRNAs, a diffuse pattern of k-mers is observed. Using these attributes, we train eight different classifiers to discriminate various ncRNA classes in plants. Support vector machines employing radial basis function show the highest accuracy (average F1 of ~96%) in discriminating ncRNAs, and the classifier is implemented as a web server, NCodR.
Epidemiology and bacterial characteristics of invasive group B streptococcus disease: a population-based study in Japan in 2010–2020
Authors: Takeuchi Noriko , Chang Bin , Takeshita Kenichi , Naito Sachiko , Takahashi Yoshiko , Hishiki Haruka , Ishiwada Naruhiko 
Published: October 2022

Abstract
This is the first report on a population-based prospective study of invasive group B streptococcus (GBS) disease among children aged <15 years conducted over a period of 11 years in Japan. This study investigated the incidence and clinical manifestations of invasive GBS disease in children in Chiba Prefecture, Japan, and analysed the serotypes and drug susceptibility of GBS strains isolated during the study period. Overall, 127 episodes of invasive GBS disease were reported in 123 patients. Of these, 124 were observed in 120 patients aged <1 year, and the remaining three episodes were reported in a 9-year-old child and two 14-year-old children with underlying disease. For patients aged <1 year, the incidence rate per 1000 live births was 0.24 (0.15–0.36). The incidences of early-onset disease and late-onset disease were 0.04 (0.0–0.09) and 0.17 (0.08–0.25), respectively. The rate of meningitis was 45.2%, and the incidence of GBS meningitis was higher than that of other invasive diseases among children in Japan. Of the 109 patients for whom prognosis was available, 7 (6.4%) died and 21 (19.3%) had sequelae. In total, 68 strains were analysed. The most common were serotype III strains (n = 42, 61.8%), especially serotype III/ST17 strains (n = 22, 32.4%). This study showed that the incidence of invasive GBS disease among Japanese children was constant during the study period. Because of the high incidence of meningitis and disease burden, new preventive strategies, such as GBS vaccine, are essential.
Micro-TESE strategy in patients with NOA caused by AZFc deletion: synchronous or asynchronous?
Authors: Mao Jiaming , Deng Chenyao , Zhao Lianming , Liu Defeng , Lin Haocheng , Zhang Zhe , Yang Yuzhuo , Zhang Haitao , Li Rong , Hong Kai , Jiang Hui 
Published: October 2022

SummaryIn the treatment of infertile patients with non-obstructive azoospermia (NOA) caused by the deletion of the azoospermia factor c region (AZFc) on the Y chromosome, synchronous and asynchronous surgical strategies are discussed. Clinical data from NOA patients with the AZFc deletion who underwent micro-TESE were analyzed retrospectively. The sperm retrieval rate (SRR) and sperm utilization rate of synchronous and asynchronous operation groups were followed up and compared. The fertilization rate, high-quality embryo rate, clinical pregnancy rate, abortion rate, and cumulative live birth rate of ICSI in patients with successful sperm retrieval were compared between the two groups. The two groups had sperm utilization rates of 98.9% (93/94) and 50.0% (14/28), respectively. The asynchronous group’s sperm consumption rates were much lower than those of the synchronous operation group. Fertilization rate, high-quality embryo rate, clinical pregnancy rate of fresh transfer cycle, abortion rate, and cumulative live birth rate of patients in the synchronous operation group with fresh sperm, and the asynchronous operation group with thawed sperm, respectively, were 30.6% vs 33.8%, 33.8% vs 40.7%, 40.0% vs 12.5%, 30.4% vs 7.1%. Between the two groups, there was no significant difference. This suggests that individuals with NOA caused by the AZFc deletion have a high possibility of successfully acquiring sperm using micro-TESE and ICSI to conceive their own offspring. Synchronous micro-TESE is recommended to improve sperm utilization rate and the cumulative live birth rate.
Effect of priming on adjunctive repetitive transcranial magnetic stimulation in treatment of late-life depression: protocol of a prospective randomized sham-controlled study
Authors: Vidya Kote L. , Srivastava Shrikant , Singh Bhupendra , Kar Sujita K. 
Published: October 2022

AbstractObjectivePriming stimulation, which involves high-frequency repetitive transcranial magnetic stimulation (rTMS) followed by low-frequency, has been shown to enhance neural response and is one of the novel paradigms found beneficial in adult patients with depression and has not been studied in late-life depression (LLD). This study aims to compare the effect of adjunctive priming vis-a-vis no priming rTMS over right dorso-lateral prefrontal cortex (DLPFC), on treatment of LLD.MethodsThis trial is registered in Clinical Trial Registry-India (CTRI) on www.ctri.nic.in. CTRI registration number: CTRI/2020/08/027230. Forty patients of LLD who are symptomatic after an adequate antidepressant trial will be randomized into 2 groups (active priming and sham priming rTMS); each receiving 10 sessions of rTMS over 2 weeks. Patients will remain blind to treatment allocation. Assessments will be done using Hamilton rating scale for depression, Geriatric Depression Scale, Hamilton rating scale for Anxiety, Somatic Symptom Severity Scale 8, Hindi Mental Status Examination, and Clinical Global Impression scale at baseline, week 1, 2, and 4. Side effect checklist will be applied after each session in both groups and at the end of 4 weeks.ResultData will be analyzed using statistical software Statistical Package for Social Sciences. Both the groups (active and sham groups) will be compared at the four given timepoints. Also, the baseline characteristics will be compared with the 3 follow-up points for any change.ConclusionThe findings of the study will give an insight to the possible role of priming to augment the effect of low-frequency rTMS in LLD.
Measuring and Explaining the Power of State Senate Leadership
Authors: Green Matthew N. 
Published: October 2022

AbstractTheories that explain the power of legislative leaders have been developed for the U.S. Congress and lower chambers of state legislatures, but they have not been tested for state senates, even though senate leaders can be quite influential. Following Mooney (2013a), I develop a new numerical index score measuring the formal power of the top chamber-elected leader of each state senate from 1995 through 2010. I then use the data to test various hypotheses explaining variation in the power of legislative leaders. The results uncover partial evidence for conditional party government theory, but only for senates that elect their own president. When the lieutenant governor serves as senate president, senators do not perceive their top chamber-elected leader as an officer able to best carry out their ideological, electoral, or policy objectives. This underscores crucial differences between senate chambers that elect their own presidents and those that do not.
Monsoon Seasonality Advanced by Opposite‐Hemisphere Continental Drift
Authors: Yin Zihan , Nie Ji 
Published: October 2022

AbstractCharacteristics of regional monsoons are largely determined by continental configuration. Motivated by the impacts of Australia on the East Asian monsoon, we investigate the modulation of the monsoon by opposite‐hemisphere continent using aquaplanet simulations with idealized continents. Simulation results show that the monsoon seasonality is advanced significantly by a near‐equator continent in the opposite‐hemisphere. In the early boreal summer, the rapid cooling of the Southern Hemisphere continents forms a high pressure on it, leading to enhanced cross‐equatorial flow and premoistening of the Northern Hemisphere monsoon, thus promoting the monsoon onset. This mechanism requires the opposite‐hemispheric continent to be within a 25° tropical belt to activate this mechanism. The results imply that the continental drift of Australia over the past 40 Ma might have shaped the seasonality of the East Asian monsoon over the geological timescale.
Spectral Characteristics of Ionospheric Disturbances Over the Southwestern Pacific From the 15 January 2022 Tonga Eruption and Tsunami
Authors: Ghent Jessica N. , Crowell Brendan W. 
Published: October 2022

AbstractOn 15 January 2022, Tonga's Hunga Tonga‐Hunga Ha'apai (HTHH) volcano violently erupted, generating a tsunami that killed three people. Acoustic‐gravity waves propagated by the eruption and tsunami caused global complex ionospheric disturbances. In this paper, we study the nature of these perturbations from Global Navigation Satellite System observables over the southwestern Pacific. After processing data from 818 ground stations, we detect supersonic acoustic waves, Lamb waves, and tsunamis, with filtered magnitudes between 1 and 7 Total Electron Content units. Phase arrivals appear superpositioned up to ∼1,000 km from HTHH and are distinct by ∼2,200 km. Within ∼2,200 km, signals have an initial low‐frequency pulse that transitions to higher frequencies. We note the presence of a faster perturbation generated 1 hr post‐eruption which crosses the tsunami disturbance ∼3,000 km from HTHH, potentially contributing to premature land arrivals. Lastly, the arrival of tsunami‐generated disturbances coincides with deep‐ocean observations.
Performance Evaluation of Modified IRI2016 and Its Application to the 24 hr Ahead Forecast foF2 Mapping Over China
Authors: Song Qian , Ye Qian , Zhang Xiaoxin , Mao Tian , Guo Jianguang 
Published: October 2022

AbstractIn this paper, we have modified the International Reference Ionosphere model 2016 (IRI2016) with the Global Navigation Satellite System total electron content data observation in China by adjusting the ionospheric index (IG12) for given location and time. The capability of the modified IRI2016 to reproduce the F2 layer critical frequency foF2 is validated for high/low solar activity conditions and disturbed geomagnetic conditions for the time period 2014–2017 over low‐latitude ionosonde station located at Sanya in China. The analysis shows that the modified IRI2016 better reproduced the variability of the observed foF2 versus time and seasons. Also, the modified IRI2016 foF2 prediction exhibits lower root mean square error and higher correlation coefficients (R) over different solar activity periods, and significantly reduces the average percentage deviations (△foF2(%)) under enhanced geomagnetic activity periods. Subsequently, the 24 hr ahead forecast foF2 map over China constructed by the combination of the modified IRI2016 and the eXtreme Gradient Boosting algorithm is presented for the first time. The promising performance of the modified IRI2016 indicates that this combination method may be an effective way to predict the ionospheric parameters, though further validations are needed in the future work.
The ataxia-linked E1081Q mutation affects the sub-plasma membrane Ca2+-microdomains by tuning PMCA3 activity
Authors: Vallese Francesca , Maso Lorenzo , Giamogante Flavia , Poggio Elena , Barazzuol Lucia , Salmaso Andrea , Lopreiato Raffaele , Cendron Laura , Navazio Lorella , Zanni Ginevra , Weber Yvonne , Kovacevic-Preradovic Tatjana , Keren Boris , Torraco Alessandra , Carrozzo Rosalba , Peretto Francesco , Peggion Caterina , Ferro Stefania , Marin Oriano , Zanotti Giuseppe , Calì Tito , Brini Marisa , Carafoli Ernesto 
Published: October 2022

AbstractCalcium concentration must be finely tuned in all eukaryotic cells to ensure the correct performance of its signalling function. Neuronal activity is exquisitely dependent on the control of Ca2+homeostasis: its alterations ultimately play a pivotal role in the origin and progression of many neurodegenerative processes. A complex toolkit of Ca2+pumps and exchangers maintains the fluctuation of cytosolic Ca2+concentration within the appropriate threshold. Two ubiquitous (isoforms 1 and 4) and two neuronally enriched (isoforms 2 and 3) of the plasma membrane Ca2+ATPase (PMCA pump) selectively regulate cytosolic Ca2+transients by shaping the sub-plasma membrane (PM) microdomains. In humans, genetic mutations inATP2B1, ATP2B2andATP2B3gene have been linked with hearing loss, cerebellar ataxia and global neurodevelopmental delay: all of them were found to impair pump activity. Here we report three additional mutations inATP2B3gene corresponding to E1081Q, R1133Q and R696H amino acids substitution, respectively. Among them, the novel missense mutation (E1081Q) immediately upstream the C-terminal calmodulin-binding domain (CaM-BD) of the PMCA3 protein was present in two patients originating from two distinct families. Our biochemical and molecular studies on PMCA3 E1081Q mutant have revealed a splicing variant-dependent effect of the mutation in shaping the sub-PM [Ca2+]. The E1081Q substitution in the full-lengthbvariant abolished the capacity of the pump to reduce [Ca2+] in the sub-PM microdomain (in line with the previously described ataxia-related PMCA mutations negatively affecting Ca2+pumping activity), while, surprisingly, its introduction in the truncatedavariant selectively increased Ca2+extrusion activity in the sub-PM Ca2+microdomains. These results highlight the importance to set a precise threshold of [Ca2+] by fine-tuning the sub-PM microdomains and the different contribution of the PMCA splice variants in this regulation.