bluuebunny/crossref_metadata_2025_split huggingface dataset:
ПОЛИМОДАЛЬНОСТЬ ГИСТОГРАММ ГЕОЛОГИЧЕСКИХ ХАРАКТЕРИСТИК КАК КРИТЕРИЙ ФЛЮИДОДИНАМИКИ
Authors: Мельник Игорь Анатольевич 
Published: September 2022

Актуальность работы обусловлена необходимостью выявления полимодальности в распределениях интенсивностей процессов различной природы. Причем причина полимодальности гистограмм несет в себе универсальный характер, а их моды могут служить поисковым критерием нефтегазовых залежей.Цель: определение величин мод в полимодальных распределениях интенсивностей вторичных процессов, которые отражают динамический режим внешнего влияния и характер насыщения песчаного коллектора, а также являются «ярлыком» условий проявления полимодальности в распределениях величин раскрытости трещин песчаной породы.Методы. На основе ранее разработанной методологии и теории унификации статистической интенсивности процессов преобразования вещества в полимодальном распределении данных интенсивностей каждая мода соотносится с определенной динамикой воздействия внешнего потока. Согласно ранее разработанной кинематической теории преобразования систем сам процесс преобразования приобретает устойчивость, только когда вектор состояния процесса трансформации в векторном пространстве временных координат (время внутреннего преобразования элементов системы и время течения внешнего воздействия в пределах радиуса влияния на внутренние элементы) определяется угловыми константами, связанными с «золотой» пропорцией. Устойчивые состояния процессов являются причиной формирования полимодального статистического распределения.Результаты. Исследования, проведенные на основе эмпирических данных, показали, что распределения выборок интенсивностей вторичных процессов в нефтегазонасыщенных песчаных породах всегда бимодальны. Меньшая величина моды бимодального распределения обусловлена закономерностью консервации углеводородами всех вторичных преобразований вещества. Центр тяжести моно- либо полимодального распределения интенсивностей в водонасыщенных пластах сдвинут в сторону большей величины. Интенсивность преобразования породы зависит от раскрытости её трещин, а распределение выборки величин раскрытости трещин также может быть полимодальным при условии приблизительного равенства расстояния от скважин (место взятия образца керна) до тектонических разломов.
МЕТОДИЧЕСКИЕ АСПЕКТЫ РАСЧЁТА ДОСТОВЕРНОГО ОБЪЕМА ШЛАМОВОЙ ПРОБЫ НА ПРИМЕРЕ МЕСТОРОЖДЕНИЯ РОССЫПНОГО ЗОЛОТА РУЧЬЯ БАЛАГАННАХ (РЕСПУБЛИКА САХА (ЯКУТИЯ))
Authors: Собянин Иван Юрьевич , Гаврилов Роман Юрьевич , Собянин Юрий Петрович 
Published: September 2022

Актуальность исследования заключается в необходимости достоверного подсчета запасов россыпных месторождений золота с использованием всей полноты геологической, минералогической и статистической информации, что в дальнейшем позволит применять данный расчёт как основу при проектировании разведочных работ на россыпных месторождениях данного района.Цель: расчёт необходимого объёма шламовой пробы для достижения достаточной достоверности результатов опробования для корректного подсчета запасов. Для достижения поставленной цели были решены следующие задачи: выбор и обоснование расчётной формулы объёма шламовой пробы; учет характера распределения золота в россыпи, влияющего на объём опробования; расчёт необходимого объема шламовой пробы на примере месторождения россыпного золота.Методы: минералогические исследования, статистическая обработка данных.Объект: результаты опробования разведочных скважин и данные, полученные при эксплуатации месторождения.Результаты. Установлено, что для россыпного месторождения золота Балаганнах объём пробы по одному сечению, необходимый для корректного подсчета запасов, составляет 157 литров. При разведке узких контуров необходимо использовать кустовое бурение скважинами с диаметром долота не менее 191 мм или бурение большим диаметром. Также для получения достоверных данных возможно использование методики размыва горных пород на продуктивном интервале. Для увеличения достоверности подсчёта запасов возможно использование поправочных коэффициентов. Применение специализированных программ для подсчёта запасов с использованием методов математической статистики позволит проводить подсчет запасов, близкий к фактическим значениям. Там, где это позволяет мощность рыхлых отложений, рекомендуется использовать проходку канав, что позволит существенно улучшить качество опробования и получить достоверные результаты.
Perfusion of brain and viscera using modified retrograde cerebral perfusion for aortic arch surgery
Authors: Yu Xiang , Lin Jing , Xiong Jiyue , Liu Xiali , Tang Zongcheng , Du Lei 
Published: September 2022

Abstract
Background: Retrograde cerebral perfusion provides a similar neuroprotective effect as antegrade cerebral perfusion during hypothermic circulatory arrest. Neither of them, however, provides blood flow for the abdominal viscera.
Methods: Here we reported a modified retrograde cerebral perfusion by tethering both superior and inferior vena cava with bands around the cannula and clamping the distal ends of both superior and inferior vena caval drainage tubes. Modified retrograde cerebral perfusion (mRCP)was performed in 8 patients.
Results: During mRCP, retrograde perfusion flow was maintained at 3.8±1.8 mL min-1 kg-1 to keep central venous pressure at 21±2 mm Hg. Removing the cross-clamp of the distal end of the inferior vena caval drainage tube, eliminated blood flow in the liver and kidney, while cerebral blood flow decreased from 21.5 to 16 cm/sec.
Conclusions: It is suggested that this technique may increase cerebral blood flow, and provide a supplementary blood flow for the lower body during circulatory arrest.
Dry EEG measurement of P3 to evaluate cognitive load during sitting, standing, and walking
Authors: Swerdloff Margaret , Hargrove Levi 
Published: September 2022

Abstract
Combining brain imaging with dual-task paradigms provides a quantitative, direct metric of cognitive load that is agnostic to the motor task. To better understand the impact of cognitive load during activities of daily living, we measured brain activity from a dry electroencephalography headset as participants attended to a stimulus paradigm eliciting event-related potentials during sitting, standing, and walking. The stimulus paradigm consisted of an auditory oddball task in which they had to report the number of oddball tones that were heard during each motor task. The P3 event-related potential, which is inversely proportional to cognitive load, was extracted from electroencephalographic signals in each condition. Results showed that P3 was significantly lower during walking compared to sitting (p = .039), indicating that cognitive load was higher during walking compared to the other activities. No significant differences in P3 were found between sitting and standing. Head motion did not have a significant impact on the measurement of cognitive load. These results encourage the use of a dry electroencephalography system to further investigate cognitive load during dynamic activities in individuals with and without motor impairments.
Pinacidil postconditioning activates HIF-1/HRE signaling and alleviate myocardial ischemia-reperfusion injury
Authors: Zhou WenJing , Li Jin , Chen Wei , Zhang Lin , Yu Tian , Zhang Yu , Wang Haiying 
Published: September 2022

Abstract
Background
Myocardium ischemia/reperfusion (I/R) injury can be fatal in cardiac operations. Pinacidil postconditioning (PPO) could effectively alleviate I/R injury. however, the mechanisms are still not clear. Hypoxia-inducible factor-1 (HIF-1) acted as a mediator of ischemic postconditioning and protected the heart against the detrimental acute I/R injury. This study aims at observing the effects of PPO on I/R injury, and exploring the function of HIF-1/hypoxia response element (HRE) pathway in PPO’s myocardial protective effects.
Methods and Results
HIF-1α inhibitor 2-methoxyestradiol (2ME2), and mitoKATP channel blocker 5-hydroxy decanoic acid (5-HD) were given before PPO to evaluate the contribution of HIF-1α and mitoKATP respectively. Cardiac function parameters (HR, LVDP, LVEDP, and dp/dtmax), infarct size, and myocardium and mitochondrial ultrastructure were evaluated. Additionally, expression of HIF-1α, and HRE related genes, i.e., VEGF, iNOS and HO-1，were detected. PPO not only improved cardiac function and ultrastructure of I/R hearts, but also reduced the infarct size in the I/R heart. In addition, PPO increased the expression of HRE related genes. These protective effects of PPO were partially reversed by HIF-1α inhibitor, and completely reversed by mitoKATP channel blocker.
Conclusion
These results indicate that PPO protects I/R myocardium depending on mitoKATP opening and HIF-1/HRE pathway.
Quality of Life Outcomes 3 Years Post Bariatric Surgery: Roux-en-y Gastric Bypass Vs. One Anastomosis Gastric Bypass
Authors: Alfonso-Ballester Raquel , Kasyanchuk Ilona , Oliver Isabel Mora , Fischer Gabriel Kraus , Fernández Rosa Martí , Rodríguez María Lapeña , Fernández Norberto Cassinello , Serrano Joaquín Ortega 
Published: September 2022

Abstract
Background: Laparoscopic One Anastomosis Gastric Bypass and Laparoscopic Roux-en-Y gastric Bypass are two of the most common bariatric techniques. We compared quality of life in both procedures, assessing pre-operative and long term post-operative differences in quality of life, physical activity level and psychosocial functioning in patients undergoing bariatric surgery.
Methods: A prospective cohort study including obese patients undergoing either Laparoscopic One Anastomosis Gastric Bypass or Laparoscopic Roux-en-Y gastric Bypass. The Moorehead-Ardelt Quality of Life Questionnaire II and Gastrointestinal Quality of Life Index (GIQLI) questionnaires were administered at 3 months preoperatively and 3 years after surgery, while the third, the Bariatric Analysis and Reporting Outcome System (BAROS), was administered only postoperatively.
Results: A total of 41 patients were included in the study. Statistically significant differences were found between the Moorehead-Ardelt Quality of Life Questionnaire II and QIGLI scores taken at both time points, across the entire cohort (p= 0.001 and p= 0.001, respectively); and between the results taken at 3 years postoperatively in the BAROS test (p= 0.001) for the entire cohort. There were no significant differences between Laparoscopic One Anastomosis Gastric Bypass and Laparoscopic Roux-en-Y gastric Bypass groups in the questionnaire scores (Moorehead-Ardelt Quality of Life Questionnaire II: p=0.526, QIGLI: p=0.990 and BAROS: p=0.753).
Conclusions: Bariatric surgery improves quality of life in operated patients, without significant differences between Laparoscopic One Anastomosis Gastric Bypass and Laparoscopic Roux-en-Y gastric Bypass techniques. Patients undergoing bariatric surgery develop higher physical activity levels, and long-term improvements in the psychosocial domain are observed over time.
Analysis and prediction of carbon balance in production-living-ecological space of Henan Province, China
Authors: Li Xiao , Wang Yinghan , wu kening , Feng Zhe 
Published: September 2022

Abstract
As the carrier of human economic activities, the change of territorial space affects the level of regional carbon balance. Therefore, with regional carbon balance as the goal, this paper proposed a framework from the perspective of production-living-ecological space and took Henan Province of China as a study area for empirical research. Firstly, the study area established an accounting inventory that considers nature, society, and economic activities to calculate carbon sequestration/emission. Then, the spatio-temporal pattern of carbon balance was analyzed by ArcGIS from 1995 to 2015. Later, the CA-MCE-Markov model was used to simulate the production-living-ecological space pattern in 2035, and carbon balance in three future scenarios was predicted. The study showed that from 1995 to 2015, the living space gradually expanded, and the aggregation rose while the production space decreased. Carbon sequestration (CS) was less than carbon emission (CE) and presented an unbalanced state of negative income in 1995, while CS exceeded CE and showed a positive income imbalance in 2015. In 2035, living space has the highest carbon emission capacity under Natural Change Scenario (NC), while ecological space has the highest carbon sequestration capacity under Ecological Protection Scenario (EP), and production space has the highest carbon sequestration capacity under Food Security Scenario (FS). The results are crucial for understanding the carbon balance changes in territorial space and supporting regional carbon balance goals in the future.
Clinical and paraclinical parameters in COVID-19 patients with nephrological disorders
Authors: AziziKia Hani , kia Vahid , Karim Bardia , Gilkalaei Parsa Rezvani , Doudaran Pooya Jafari , Farid Armita , Amini Yasin Naeemi , Talebi Solmaz 
Published: September 2022

Abstract
Background: In this study, we aimed to examine the relationship between kidney patients’ COVID-19 status and their symptoms, laboratory values, and ICU admission status. We also evaluated the association between COVID-19-positive kidney patients’ age, gender, smoking status, history of underlying diseases and urea and creatinine levels, and their ICU admission status and mortality. Finally, we analyzed the differences in laboratory values in kidney patients with and without a history of diabetes or cardiovascular disease.
Methods: In this cross-sectional study, 253 patients with a history of kidney disease were included. COVID-19 was diagnosed by positive RT-qPCR. Symptoms, laboratory findings, and outcomes were extracted from the patients’ records and statistically investigated.
Results: Fever, chills, myalgia, arthralgia, cough, anorexia, nausea, fatigue, headache, mental status deterioration, and smoking were more common in COVID-19-positive kidney patients compared to COVID-19-negative ones. White blood cells (WBC), platelets, and urea were lower and hemoglobin and hematocrit were higher in the former group. WBC, urea, and blood sugar (BS) levels were higher in kidney patients with a history of cardiovascular disease compared to kidney patients without such a history. Low-density lipoprotein cholesterol (LDL) was lower in the former group. Hemoglobin and hematocrit were lower in diabetic kidney patients compared to non-diabetic kidney patients. BS, triglycerides, and erythrocyte sedimentation rate (ESR) were higher in the former group. History of underlying diseases and abnormal creatinine was associated with increased ICU admission and age ≥ 50, male gender and abnormal creatinine were associated with increased mortality in COVID-19-positive kidney patients.
Conclusions: Smoking cessation should be encouraged in kidney patients. Fever, chills, myalgia, arthralgia, cough, anorexia, nausea, fatigue, headache, and mental status deterioration in kidney patients can indicate COVID-19 infection. Monitoring WBC and platelet counts in COVID-19-positive kidney patients, WBC, urea, and BS in kidney patients with a history of cardiovascular disease, and ESR, triglycerides, and hemoglobin in diabetic kidney patients can prove beneficial in their management. Age, gender, history of underlying diseases, and creatinine levels can be important prognostic markers in COVID-19-positive kidney patients.
A self-microemulsion enhances oral absorption of Docetaxel by inhibiting P-glycoprotein and CYP metabolism
Authors: Tong Le , Zhou ZeYang , Wang Gang , Wu Chao 
Published: September 2022

Abstract
Oral absorption of docetaxel was limited by drug efflux pump p-glycoprotein (P-gp) and cytochrome P450 enzyme (CYP 450). Therefore, co-loading agent that inhibits P-gp and CYP 450 in self-nanoemulsifying drug delivery system (SMEs) is considered as a promising strategy for oral delivery of docetaxel. In this study, curcumin was selected as an inhibitor of P-gp and CYP 450, and it was coencapsuled in SMEs to improve the oral bioavailability of docetaxel. SMEs quickly dispersed in water within 20 seconds, and the droplet size was 32.23 ± 2.21 nm. The release rate of curcumin from DC-SMEs was higher than that of docetaxel in vitro. Compared with free docetaxel, SMEs significantly increased the permeability of docetaxel by 4.6 times. And competitive experiments showed that the increased permeability was the result of inhibition of p-gp. The half-life and oral bioavailabilty of DC-SMEs increased about 1.7 times and 1.6 times than docetaxel SMEs, which indicated that its good pharmacokinetic behavior was releated to the restriction of hepatic first-pass metabolism. In conclusion, DC-SMEs was an ideal platform to facilitate oral delivery of docetaxel through inhibited P-gp and CYP 450.
Predictive Factors of Renal Failure in Covid 19 Patients at the Anti-covid Center in Lome, Togo
Authors: SABI Kossi Akomola , KOTOSSO Awéréou , AMEKOUDI Yoan Makafui , KAZA Béfa NOTO – KADOU – , BLATOME Laune Odilon , DOLAAMA Badomta , SABI Ayodélé Jonathan , GBAHBANG Oscar GNIRIMI , AFFO Loutou Ahoub-Laye , VIGAN Jacques 
Published: September 2022

Abstract
Background: Angiotensin-converting enzyme 2 has been identified as the receptor that allows the entry of SarsCov2 into the human cell. Its expression in the kidney is 100 times higher than in the lung; thus, making the kidney an excellent target for SarsCov2 infection manifesting as renal failure (RF). The objective of this study was to determine the predictive factors of RF during covid-19 in the Togolese context.
Patients and Methods: This was a retrospective descriptive and analytical study conducted at the Lomé Anti-Covid Center including the records of patients hospitalized for covid 19, of age ≥ 18 years and having performed a creatinemia. RF was defined by a GFR < 60 ml/min/1.73 m2 calculated according to the MDRD formula. Patients were randomized into 2 groups according to GFR<60 or not. Statistical tests used were Pearson's Chi-2 test or Fisher's exact test for qualitative variables and Mann-Whitney test or Wilcoxon test for quantitative variables. The significance level was set at 0.05. Univariate and multivariate logistic regression was performed to search for associated factors.
Results: 482 patients were selected for this study with a mean age of 58.02 years. Sixty-five percent of the patients were men, i.e., a sex ratio of 1.88. Fifty-two patients had RF, i.e., a frequency of 10.8%. There were 65% men (315 cases), for a sex ratio (M/F) of 1.88. Risk factors for renal failure in covid-19 were age ≥ 65 years (ORa 2.42; CIa95% [1.17 - 4.95]; p=0.016), anemia (ORa 2.49; CIa95% [1.21 - 5.26]; p=0.015), moderate (ORa 13; CIa95% [2.30 - 2.44]; p=0.017), severe (ORa 26.2; CIa95% [4.85 - 4.93]; p= 0.002) and critical (ORa 108; CIa95% [16.5 - 21.76]; p<0.001) severity stages at admission.
Conclusion: Renal failure would therefore be related to the severity of covid 19 and is the most formidable factor, conditioning the course of the disease and the patient's vital prognosis.
Regular Lung Recruitment Maneuvers during High-Frequency Oscillatory Ventilation in Extremely Preterm Infants: A Randomized Controlled Trial
Authors: Werther Tobias , Kueng Erik , Aichhorn Lukas , Pummer Linda , Goeral Katharina , Berger Angelika , Hermon Michael , Klebermass-Schrehof Katrin 
Published: September 2022

Abstract
Background
Lung recruitment maneuvers (LRMs) improve lung volume at initiation of high-frequency oscillatory ventilation (HFOV), but it is unclear when to repeat LRMs. We evaluated the efficiency of scheduled LRMs.
Methods
In a randomized controlled trial, extremely preterm infants on HFOV received either LRMs at 12-hour intervals and when clinically indicated (intervention) or only when clinically indicated (control). The primary outcome was the cumulative oxygen saturation index (OSI) over HFOV time, limited to 7 days. Additionally, LRMs were analyzed with respect to OSI improvement.
Results
Fifteen infants were included in each group. The median (range) postmenstrual age and weight at HFOV start were 24+2 (23+0, 27+6) weeks and 615 (435, 920) g. The mean (SD) cumulative OSI was 4.95 (1.72) in the intervention versus 5.30 (2.08) in the control group (p=0.61). The mean (SD) number of LRMs in 12 hours was 1.3 (0.2) in the intervention versus 1.1 (0.5) in the control group (p=0.13). Performing LRM when FiO2>0.6 resulted in a mean OSI reduction of 3.6.
Conclusion
Regular versus clinically indicated LRMs were performed with equal frequency in preterm infants during HFOV, and consequently, no difference in lung volume was observed. LRMs seem to be most efficient at high FiO2.
Trial registration
ClinicalTrials.gov ID: NCT04289324 (28/02/2020).
Scrutinizing a superconductor-topological insulator interface
as a platform for topological superconductivity
Authors: Rüßmann Philipp , Blügel Stefan 
Published: September 2022

Abstract
Interfacing a topological insulator (TI) with an s-wave superconductor (SC) is a promising material platform that offers the possibility to realize a topological superconductor through which Majorana-based topologically protected qubits can be engineered. In our computational study of the prototypical SC/TI interface between Nb and Bi2Te3, we identify the benefits and possible bottlenecks of this potential Majorana material platform. Bringing Nb in contact with the TI film induces charge doping from the SC to the TI, which shifts the Fermi level into the TI conduction band. For thick TI films, this results in band bending leading to the population of trivial TI quantum-well states at the interface. In the superconducting state, we uncover that the topological surface state experiences a sizable superconducting gap-opening at the SC/TI interface, which is furthermore robust against fluctuations of the Fermi energy. We also show that the trivial interface state is only marginally proximitized, potentially obstructing the realization of Majorana-based qubits in this material platform.
Reliable biomarkers for decreased spatial navigation in the Young People with Obesity: Increased serum CRP and QUIN levels
Authors: Kucukkarapinar Melike , Simsek Gokcenur , Ucar Onder , Koca Arzu Or , Yetkin İlhan , Cosar Behcet 
Published: September 2022

Abstract
Background: Obesity is increasing morbidity and mortality. Obesity and cognitive impairment research have focused on the negative consequences of obesity-related medical diseases on cognition. This study aimed to examine the effect of obesity on spatial navigation, and the relationship between changes in tryptophan kynurenine metabolites and spatial navigation in the people with obesity between 18 and 35 years of age.
Methods: In 29 adults with obesity and 25 normal weight adults, we examined plasma levels of CRP, leptin, kynurenine (KYN), tryptophan (TRP), kynurenic acid (KYNA), 3-hydroxykynurenine (3-HK), and quinolinic acid (QUIN), as well as the TRP/KYN, KYNA/3-HK, and KYNA/QUIN ratios. Body and abdominal fat composition (AFC) were also examined. The EAT-26 was used to assess eating attitudes. We used Montreal cognitive assessment (MOCA), Reaction Time (RT), Rey-Osterrieth Complex Figure Test (RCFT), and Virtual-Reality-Based Route-Learning Test with subtests Route repetition task (RPT), Route retraction task (RRT), Directional-approach task (DAT) to measure cognitive abilities.
Results: In participants with obesity, the EAT-26 score was higher (p= 0.006), but the MOCA total score (p=0.03) and RCFT copy subscale score (p=0.03), as well as the RPT (p< 0,001), RRT p= 0,004), and DAT (p< 0,001) percentage of correct answers, was lower than normal-weight participants. The QUIN was found to be a negative predictor of RRT (B=-7.29, CI: -12.98, -1.59, -0.31, p=0.01) and DAT (B=-6.15, CI: -9.83, -2.46, p=0.002), while AFC was a negative predictor of RPT (B=-1.01, CI: -1.47, -0.55, p< 0.001). CRP was likewise greater in participants with obesity and a negative predictor of RRT (B=-7.96, CI: -14.30, -1.62, p=0.02) and DAT (B=-9.25, CI: -16.34, -2.17, p=0.012).
Discussion: The performance of participants with obesity without comorbidities was worse on visuospatial tests than healthy controls. QUIN and CRP may also help identify new serum biomarkers of poor visuospatial cognition in young adults with obesity