bluuebunny/crossref_metadata_2025_split huggingface dataset:
Childhood adversities and mental disorders in first-year college students: results from the World Mental Health International College Student Initiative
Authors: Husky Mathilde M. , Sadikova Ekaterina , Lee Sue , Alonso Jordi , Auerbach Randy P. , Bantjes Jason , Bruffaerts Ronny , Cuijpers Pim , Ebert David D. , Garcia Raùl Gutiérrez , Hasking Penelope , Mak Arthur , McLafferty Margaret , Sampson Nancy A. , Stein Dan J. , Kessler Ronald C. ,   WHO WMH-ICS collaborators
Published: January 2022

AbstractBackgroundThis study investigates associations of several dimensions of childhood adversities (CAs) with lifetime mental disorders, 12-month disorder persistence, and impairment among incoming college students.MethodsData come from the World Mental Health International College Student Initiative (WMH-ICS). Web-based surveys conducted in nine countries (n = 20 427) assessed lifetime and 12-month mental disorders, 12-month role impairment, and seven types of CAs occurring before the age of 18: parental psychopathology, emotional, physical, and sexual abuse, neglect, bullying victimization, and dating violence. Poisson regressions estimated associations using three dimensions of CA exposure: type, number, and frequency.ResultsOverall, 75.8% of students reported exposure to at least one CA. In multivariate regression models, lifetime onset and 12-month mood, anxiety, and substance use disorders were all associated with either the type, number, or frequency of CAs. In contrast, none of these associations was significant when predicting disorder persistence. Of the three CA dimensions examined, only frequency was associated with severe role impairment among students with 12-month disorders. Population-attributable risk simulations suggest that 18.7–57.5% of 12-month disorders and 16.3% of severe role impairment among those with disorders were associated with these CAs.ConclusionCAs are associated with an elevated risk of onset and impairment among 12-month cases of diverse mental disorders but are not involved in disorder persistence. Future research on the associations of CAs with psychopathology should include fine-grained assessments of CA exposure and attempt to trace out modifiable intervention targets linked to mechanisms of associations with lifetime psychopathology and burden of 12-month mental disorders.
Efficacy of cognitive therapy and behavior therapy for menopausal symptoms: a systematic review and meta-analysis
Authors: Ye Mengfei , Shou Mengna , Zhang Jian , Hu Baiqi , Liu Chunyan , Bi Chenchen , Lv Tingting , Luo Fangyi , Zhang Zeying , Liang Shenglin , Feng Hong , Qian Chao , Cao Shilin , Liu Zheng 
Published: January 2022

AbstractBackgroundT long-term effects of cognitive therapy and behavior therapy (CTBT) for menopausal symptoms are unknown, and whether the effects are different between natural menopause and treatment-induced menopause are currently unclear. Therefore, we sought to conduct an accurate estimate of the efficacy of CTBT for menopausal symptoms.MethodsWe conducted searches of Cochrane Library, EMBASE, PsycINFO, PubMed, and Web of Science databases for studies from 1 January 1977 to 1 November 2021. Randomized controlled trials (RCTs) comparing intervention groups to control groups for menopausal symptoms were included. Hedge's g was used as the standardized between-group effect size with a random-effects model.ResultsWe included 14 RCTs comprising 1618 patients with a mean sample size of 116. CTBT significantly outperformed control groups in terms of reducing hot flushes [g = 0.39, 95% confidence interval (CI) 0.23–0.55, I2 = 45], night sweats, depression (g = 0.50, 95% CI 0.34–0.66, I2 = 51), anxiety (g = 0.38, 95% CI 0.23–0.54, I2 = 49), fatigue, and quality of life. Egger's test indicated no publication bias.ConclusionsCTBT is an effective psychological treatment for menopausal symptoms, with predominantly small to moderate effects. The efficacy is sustained long-term, although it declines somewhat over time. The efficacy was stronger for natural menopause symptoms, such as vasomotor symptoms, than for treatment-induced menopause symptoms. These findings provide support for treatment guidelines recommending CTBT as a treatment option for menopausal symptoms.
Olfactory reference plus Truman symptoms in one patient with Gilbert syndrome and antiphospholipid antibodies (Hughes disease) secondary to probable chronic Lyme neuroborreliosis
Authors: Almeida e Melo João , Gama Marques João 
Published: January 2022

AbstractAfter reading an article in the journal, regarding affective disorders in patients with rare illnesses, the authors would like to discuss a case of non-affective psychosis, presenting with olfactory reference and Truman symptoms, in a patient with three unusual conditions: Gilbert disease, Hughes syndrome and Lyme neuroborreliosis.
Subgraph densities in a surface
Authors: Huynh Tony , Joret Gwenaël , Wood David R. 
Published: January 2022

AbstractGiven a fixed graphHthat embeds in a surface$\Sigma$, what is the maximum number of copies ofHin ann-vertex graphGthat embeds in$\Sigma$? We show that the answer is$\Theta(n^{f(H)})$, wheref(H) is a graph invariant called the ‘flap-number’ ofH, which is independent of$\Sigma$. This simultaneously answers two open problems posed by Eppstein ((1993)J. Graph Theory17(3) 409–416.). The same proof also answers the question for minor-closed classes. That is, ifHis a$K_{3,t}$minor-free graph, then the maximum number of copies ofHin ann-vertex$K_{3,t}$minor-free graph G is$\Theta(n^{f'(H)})$, wheref′(H) is a graph invariant closely related to the flap-number ofH. Finally, whenHis a complete graph we give more precise answers.
Musicking and DancingImbaluat Namasho: Enacting Indigenous Education Among the Bagisu, Uganda
Authors: MAKWA DOMINIC D.B. 
Published: January 2022

AbstractThis paper discusses how the activities during which people gather to create, perform, and transmitimbalucircumcision music and dance at Namasho Cultural Site (NCS) become a platform for the Bagisu of the Balutseshe clan to tutor boys about society’s gender ideology, social histories, and rituals of the sacred swamp, thus turning the place into a communal classroom for imparting this knowledge. Due to the changing context of contemporary Bagisu, I argue for efforts to archive these events to make them accessible by future generations in order to upholdimbaluperformances as a mechanism of knowledge production and dissemination.
“That is Why I am Telling this Story”: Musical Analysis as Insight into the Transmission of Knowledge and Performance Practice of a Wapurtarli Song by Warlpiri Women from Yuendumu, Central Australia
Authors: CURRAN GEORGIA , YEOH CALISTA 
Published: January 2022

AbstractInsights into the knowledge, performance, and transmission of songs are pivotal in ensuring the survival of traditional Aboriginal songs. We present the first in-depth musical analysis of a Wapurtarli yawulyu song set sung by Warlpiri women from Yuendumu, Central Australia, recorded in December 2006 with a solo lead singer accompanied by a small group. Our musical analysis reveals that there are various interlocking parts of a song, and this can make it difficult for current generations to learn songs. The context of musical endangerment and the musical analyses presented in our study show that contemporary spaces for learning yawulyu must consider the complex components that come together for a song set to be properly performed.
Seismic Site Response Inferred From Records at a Dense Linear Array Across the Chenghai Fault Zone, Binchuan, Yunnan
Authors: Song Junhao , Yang Hongfeng 
Published: January 2022

AbstractLow‐velocity zones (LVZ) in the shallow crust such as basins infilled with unconsolidated sediments could significantly amplify seismic waves and cause intense ground motions. In this study, we estimate the seismic site response in the Binchuan basin across the active Chenghai fault zone in northwest Yunnan Province, Southwest China using data from a large‐aperture (∼8 km) dense linear array of 125 three‐component seismometers deployed in 2018 for ∼1 month. We observe that local earthquakes with larger epicentral distances tend to produce stronger spatial variability in peak ground velocity (PGV) across the array. The PGV values are overall larger in the middle of the array than the two sides, especially in the horizontal directions, which is consistent with both tomographic and traveltime results. Using both nearby and distant earthquakes, we find that horizontal ground motions from 0.2 to 2 Hz at stations inside the LVZ are up to 20 times as large as that outside, and a more localized zone (∼500 m wide) enclosing the fault surface trace is characterized by broader frequency bands and larger factors of amplification. As the distance from the fault increases, amplification factors become smaller while the lower limit of the amplification frequency band gradually increases. Variations in predicted ground motion from one‐dimensional SH‐wave modeling reveal amplification and attenuation effects of the LVZ, suggesting that strong lateral heterogeneity should be considered. Our results demonstrate that based on dense array data, analyzing seismic site response is an alternative method to effectively constrain the shallow subsurface fault structure.
Evaluating Climate Models’ Cloud Feedbacks Against Expert Judgment
Authors: Zelinka Mark D. , Klein Stephen A. , Qin Yi , Myers Timothy A. 
Published: January 2022

AbstractThe persistent and growing spread in effective climate sensitivity (ECS) across global climate models necessitates rigorous evaluation of their cloud feedbacks. Here we evaluate several cloud feedback components simulated in 19 climate models against benchmark values determined via an expert synthesis of observational, theoretical, and high‐resolution modeling studies. We find that models with smallest feedback errors relative to these benchmark values generally have moderate total cloud feedbacks (0.4–0.6 W m−2 K−1) and ECS (3–4 K). Those with largest errors generally have total cloud feedback and ECS values that are too large or too small. Models tend to achieve large positive total cloud feedbacks by having several cloud feedback components that are systematically biased high rather than by having a single anomalously large component, and vice versa. In general, better simulation of mean‐state cloud properties leads to stronger but not necessarily better cloud feedbacks. The Python code base provided herein could be applied to developmental versions of models to assess cloud feedbacks and cloud errors and place them in the context of other models and of expert judgment in real‐time during model development.
Floodplain Sediment Storage Timescales of the Laterally Confined Meandering Powder River, USA
Authors: Huffman Max E. , Pizzuto James E. , Trampush Sheila M. , Moody John A. , Schook Derek M. , Gray Harrison J. , Mahan Shannon A. 
Published: January 2022

AbstractAs sediment is transported through river corridors, it typically spends more time in storage than transport, and as a result, sediment delivery timescales are controlled by the duration of storage. Present understanding of storage timescales is largely derived from models or from field studies covering relatively short (≤102 year) time spans. Here we quantify the storage time distribution for a 17 km length of Powder River in Montana, USA by determining the age distribution of eroded sediment. Our approach integrates surveyed cross‐sections, analysis of historical aerial imagery, aerial LiDAR, geomorphic mapping, and age control provided by optically stimulated luminescence (OSL) and dendrochronology. Sediment eroded by Powder River from 1998 to 2013 ranges from a few years to ∼5,000 years in age; ages are exponentially distributed (r2 = 0.78; Anderson‐Darling p value 0.003). Eroded sediment is derived from Powder River's meander belt (∼900 m wide), which is only 1.25 times its meander wavelength, a value reflecting valley confinement rather than free meandering. The mean storage time, 824 years (95% C.I. 610–1030 years), is similar to the time required to rework deposits of Powder River's meander belt based on an average meander migration rate of ∼1 m/yr, implying that storage time distributions of confined meandering rivers can be quantified from remotely sensed estimates of meander belt width and channel migration rates. Heavy‐tailed storage time distributions, frequently cited from physical and numerical modeling studies, may be restricted to unconfined meandering rivers.
Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
Authors: Fiskus Warren , Boettcher Steffen , Daver Naval , Mill Christopher P. , Sasaki Koji , Birdwell Christine E. , Davis John A. , Takahashi Koichi , Kadia Tapan M. , DiNardo Courtney D. , Jin Qi , Qi Yuan , Su Xiaoping , McGeehan Gerard M. , Khoury Joseph D. , Ebert Benjamin L. , Bhalla Kapil N. 
Published: January 2022

AbstractTreatment with Menin inhibitor (MI) disrupts the interaction between Menin and MLL1 or MLL1-fusion protein (FP), inhibits HOXA9/MEIS1, induces differentiation and loss of survival of AML harboring MLL1 re-arrangement (r) and FP, or expressing mutant (mt)-NPM1. Following MI treatment, although clinical responses are common, the majority of patients with AML with MLL1-r or mt-NPM1 succumb to their disease. Pre-clinical studies presented here demonstrate that genetic knockout or degradation of Menin or treatment with the MI SNDX-50469 reduces MLL1/MLL1-FP targets, associated with MI-induced differentiation and loss of viability. MI treatment also attenuates BCL2 and CDK6 levels. Co-treatment with SNDX-50469 and BCL2 inhibitor (venetoclax), or CDK6 inhibitor (abemaciclib) induces synergistic lethality in cell lines and patient-derived AML cells harboring MLL1-r or mtNPM1. Combined therapy with SNDX-5613 and venetoclax exerts superior in vivo efficacy in a cell line or PD AML cell xenografts harboring MLL1-r or mt-NPM1. Synergy with the MI-based combinations is preserved against MLL1-r AML cells expressing FLT3 mutation, also CRISPR-edited to introduce mtTP53. These findings highlight the promise of clinically testing these MI-based combinations against AML harboring MLL1-r or mtNPM1.
The antibody response of haematological malignancies to COVID-19 infection and vaccination
Authors: Seebacher Nicole A. 
Published: January 2022

SummaryCancer patients with COVID-19 have reduced survival. While most cancer patients, like the general population, have an almost 100% rate of seroconversion after COVID-19 infection or vaccination, patients with haematological malignancies have lower seroconversion rates and are far less likely to gain adequate protection. This raises the concern that patients with haematological malignancies, especially those receiving immunosuppressive therapies, may still develop the fatal disease when infected with COVID-19 after vaccination. There is an urgent need to develop Guidelines to help direct vaccination schedules and protective measures in oncology patients, differentiating those with haematological malignancies and those in an immunocompromised state.
Long noncoding RNA FAM225A promotes the malignant progression of gastric cancer through the miR-326/PADI2 axis
Authors: Ma Xiang , Wang Gang , Fan Hao , Li Zengliang , Chen Wangwang , Xiao Jian , Ni Peidong , Liu Kanghui , Shen Kuan , Wang Yuanhang , Xu Zekuan , Yang Li 
Published: January 2022

AbstractGastric cancer (GC) is a global health problem and further studies of its molecular mechanisms are needed to identify effective therapeutic targets. Although some long noncoding RNAs (lncRNAs) have been found to be involved in the progression of GC, the molecular mechanisms of many GC-related lncRNAs remain unclear. In this study, a series of in vivo and in vitro assays were performed to study the relationship between FAM225A and GC, which showed that FAM225A levels were correlated with poor prognosis in GC. Higher FAM225A expression tended to be correlated with a more profound lymphatic metastasis rate, larger tumor size, and more advanced tumor stage. FAM225A also promoted gastric cell proliferation, invasion, and migration. Further mechanistic investigation showed that FAM225A acted as a miR-326 sponge to upregulate its direct target PADI2 in GC. Overall, our findings indicated that FAM225A promoted GC development and progression via a competitive endogenous RNA network of FAM225A/miR-326/PADI2 in GC, providing insight into possible therapeutic targets and prognosis of GC.
Complementing the phenotypical spectrum of TUBA1A tubulinopathy and its role in early-onset epilepsies
Authors: Schröter Julian , Popp Bernt , Brennenstuhl Heiko , Döring Jan H. , Donze Stephany H. , Bijlsma Emilia K. , van Haeringen Arie , Huhle Dagmar , Jestaedt Leonie , Merkenschlager Andreas , Arelin Maria , Gräfe Daniel , Neuser Sonja , Oates Stephanie , Pal Deb K. , Parker Michael J. , Lemke Johannes R. , Hoffmann Georg F. , Kölker Stefan , Harting Inga , Syrbe Steffen 
Published: January 2022

AbstractTUBA1A tubulinopathy is a rare neurodevelopmental disorder associated with brain malformations as well as early-onset and intractable epilepsy. As pathomechanisms and genotype-phenotype correlations are not completely understood, we aimed to provide further insights into the phenotypic and genetic spectrum. We here present a multicenter case series of ten unrelated individuals from four European countries using systematic MRI re-evaluation, protein structure analysis, and prediction score modeling. In two cases, pregnancy was terminated due to brain malformations. Amongst the eight living individuals, the phenotypic range showed various severity. Global developmental delay and severe motor impairment with tetraparesis was present in 63% and 50% of the subjects, respectively. Epilepsy was observed in 75% of the cases, which showed infantile onset in 83% and a refractory course in 50%. One individual presented a novel TUBA1A-associated electroclinical phenotype with evolvement from early myoclonic encephalopathy to continuous spike-and-wave during sleep. Neuroradiological features comprised a heterogeneous spectrum of cortical and extracortical malformations including rare findings such as cobblestone lissencephaly and subcortical band heterotopia. Two individuals developed hydrocephalus with subsequent posterior infarction. We report four novel and five previously published TUBA1A missense variants whose resulting amino acid substitutions likely affect longitudinal, lateral, and motor protein interactions as well as GTP binding. Assessment of pathogenic and benign variant distributions in synopsis with prediction scores revealed sections of variant enrichment and intolerance to missense variation. We here extend the clinical, neuroradiological, and genetic spectrum of TUBA1A tubulinopathy and provide insights into residue-specific pathomechanisms and genotype-phenotype correlations.
Physical geography, isolation by distance and environmental variables shape genomic variation of wild barley (Hordeum vulgare L. ssp. spontaneum) in the Southern Levant
Authors: Chang Che-Wei , Fridman Eyal , Mascher Martin , Himmelbach Axel , Schmid Karl 
Published: January 2022

AbstractDetermining the extent of genetic variation that reflects local adaptation in crop-wild relatives is of interest for the purpose of identifying useful genetic diversity for plant breeding. We investigated the association of genomic variation with geographical and environmental factors in wild barley (Hordeum vulgare L. ssp. spontaneum) populations of the Southern Levant using genotyping by sequencing (GBS) of 244 accessions in the Barley 1K+ collection. The inference of population structure resulted in four genetic clusters that corresponded to eco-geographical habitats and a significant association between lower gene flow rates and geographical barriers, e.g. the Judaean Mountains and the Sea of Galilee. Redundancy analysis (RDA) revealed that spatial autocorrelation explained 45% and environmental variables explained 15% of total genomic variation. Only 4.5% of genomic variation was solely attributed to environmental variation if the component confounded with spatial autocorrelation was excluded. A synthetic environmental variable combining latitude, solar radiation, and accumulated precipitation explained the highest proportion of genomic variation (3.9%). When conditioned on population structure, soil water capacity was the most important environmental variable explaining 1.18% of genomic variation. Genome scans with outlier analysis and genome-environment association studies were conducted to identify adaptation signatures. RDA and outlier methods jointly detected selection signatures in the pericentromeric regions, which have reduced recombination, of the chromosomes 3H, 4H, and 5H. However, selection signatures mostly disappeared after correction for population structure. In conclusion, adaptation to the highly diverse environments of the Southern Levant over short geographical ranges had a limited effect on the genomic diversity of wild barley. This highlighted the importance of nonselective forces in genetic differentiation.
Ensemble streamflow forecasting based on variational mode decomposition and long short term memory
Authors: Sun Xiaomei , Zhang Haiou , Wang Jian , Shi Chendi , Hua Dongwen , Li Juan 
Published: January 2022

AbstractReliable and accurate streamflow forecasting plays a vital role in the optimal management of water resources. To improve the stability and accuracy of streamflow forecasting, a hybrid decomposition-ensemble model named VMD-LSTM-GBRT, which is sensitive to sampling, noise and long historical changes of streamflow, was established. The variational mode decomposition (VMD) algorithm was first applied to extract features, which were then learned by several long short-term memory (LSTM) networks. Simultaneously, an ensemble tree, a gradient boosting tree for regression (GBRT), was trained to model the relationships between the extracted features and the original streamflow. The outputs of these LSTMs were finally reconstructed by the GBRT model to obtain the forecasting streamflow results. A historical daily streamflow series (from 1/1/1997 to 31/12/2014) for Yangxian station, Han River, China, was investigated by the proposed model. VMD-LSTM-GBRT was compared with respect to three aspects: (1) feature extraction algorithm; ensemble empirical mode decomposition (EEMD) was used. (2) Feature learning techniques; deep neural networks (DNNs) and support vector machines for regression (SVRs) were exploited. (3) Ensemble strategy; the summation strategy was used. The results indicate that the VMD-LSTM-GBRT model overwhelms all other peer models in terms of the root mean square error (RMSE = 36.3692), determination coefficient (R2 = 0.9890), mean absolute error (MAE = 9.5246) and peak percentage threshold statistics (PPTS(5) = 0.0391%). The addressed approach based on the memory of long historical changes with deep feature representations had good stability and high prediction precision.