bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of maternal age on the mode of delivery following induction of labor in nulliparous term pregnancies: A retrospective cohort study
Authors: Sharami Seyedeh Hajar , Kabodmehri Roya , Hosseinzadeh Fatemeh , Montazeri Sina , Ghalandari Maryam , Dalil Heirati Seyedeh Fatemeh , Ershadi Sarvenaz 
Published: May 2022

AbstractBackground and AimIncreased maternal age at the time of pregnancy and labor is believed to have potential complications. To evaluate the effects of maternal age on the mode of delivery among nulliparous women with term pregnancies who underwent labor induction.MethodsIn this retrospective cohort study, 313 women with the gestational age of at least ≥37 weeks, were enrolled. They were divided based on their maternal ages as: Group A < 35 years old (y/o) and Group B ≥ 35 y/o patients. Demographic features and other variables (i.e., past medical history, social history, indications and methods of labor induction, causes of cesarean delivery) were recorded from patients' files. Final outcomes were categorized as: primary (i.e., rate of cesarean section: C/S) and (b) secondary (i.e., duration of labor, postpartum complications, neonatal variables). All data were analyzed by the SPSS ver.21 software.ResultsMedian and interquartile ranges of gestational age were not significantly different, comparing the two groups (p = 0.415), although these variables were significantly different regarding maternal height among the two groups (p = 0.007). There was a significant relationship between the methods of labor induction among the two groups (p = 0.005). There was a prominent statistical relationship between (a) C/S deliveries and also (b) indications of C/S among the two groups (p = 0.004 and p = 0.033, respectively). Univariate logistic regression test revealed maternal age groups, neonatal weight, and history of underlying diseases had significant results (p < 0.05).ConclusionsIncreased maternal age is associated with higher rates of CS among nulliparous women with term pregnancies who underwent labor induction.
Significance of solar radiation and magnetic dipole impact on micropolar ferromagnetic fluid flow via an extending surface using finite element approach
Authors: Hussain Sajjad , Siddique Imran , Ali Bagh , Ahmad Farooq , Ali Muazzam 
Published: May 2022

AbstractThe Galerkin finite element approach is utilized to examine the significance of magnetic dipole and solar radiation on the dynamic of micropolar ferromagnetic fluid due to extending stretch surface. The magnetic field and the significant power of magnetic dipole help to stabilize the magnetized nanoparticles inside the fluid. The solid nano‐sized particles are incorporated due to enhanced host fluid thermal conductivity, which plays a significant role in heat exchangers, modern nano‐technology, electronics chips, and materials sciences. In the present elaborated problem, with the aid of similarity transformation, the partial differential formulation is transformed into a set of dimensionless ordinary differential equations, and finds a numerical solution via finite element discretization. The detailed parametric study corresponding to various physical conditions is carried out to reveal that incremented ferromagnetic interaction variable recedes the flow speed, but it grows the thermal and microrotation distributions, and the decline in temperature is observed with the increment of ratio, viscous dissipation, and curie temperature parameters. The reliability of the Matlab code and validity of the solution has been tested with already available literature data and see a good comparison of current results.
Intelligent diagnosis system of hepatitis C virus: A probabilistic neural network based approach
Authors: Terlapu Panduranga Vital , Gedela Stalin Babu , Gangu Vijay Kumar , Pemula Rambabu 
Published: May 2022

AbstractIn recent years, early detection of hepatitis C virus (HCV) disease has been a vital task in the medical science field. HCV became the main health concern to the public, as it was noticed to have more blood donors in Egypt equated to other nationalities. The WHO assessed that in 2019, around 290 000 individuals died from hepatitis C, which says the seriousness of the HCV disease. So, early prediction, preventions, and curing the disease are vital components to save individuals from HCV. In this paper, we propose and investigate experimental results of the five machine learning (ML) models and probabilistic neural network (PNN) based approach to detect the HCV utilizing University of Califonia Irvine (UCI) ML Egyptian HCV dataset. We also analyze the statistical reports of HCV stages and their features. As per result analysis, the random forest (RF) ML model performs superiorly to other traditional ML algorithms with 97.5% of accuracy. The PNN (incremental hidden layer [HL] neurons) based proposal model shows a very high performance (99.6% of accuracy) at 30‐HL neurons of PNN. As per comparative analysis, the proposed model is superior to experimental basic ML models, and early HCV disease works are related to this area. This research focuses on early detection, prevention, and challenges of handling HCV.
Zoledronic acid‐induced oxidative damage and endoplasmic reticulum stress‐mediated apoptosis in human embryonic kidney (HEK‐293) cells
Authors: Kara Mehtap , Boran Tuğçe , Öztaş Ezgi , Jannuzzi Ayse Tarbin , Özden Sibel , Özhan Gül 
Published: May 2022

AbstractZoledronic acid, a nitrogen‐containing bisphosphonate drug, is used for the treatment of osteoporosis, Paget's disease of bone, and tumor‐induced osteolysis. Zoledronic acid has also gained a place in cancer treatment due to its cytotoxic and antiproliferative effects in many cancer cells. Although zoledronic acid is considered safe, kidney damage is still one of the concerns in therapeutic doses. In the study, the aim was to assess the nephrotoxic profiles of zoledronic acid in the human embryonic kidney (HEK‐293) cells. Cytotoxicity evaluation was performed by 3‐[4,5‐dimethylthiazol‐2‐yl]−2,5‐diphenyl‐tetrazolium bromide (MTT) and neutral red uptake tests, while oxidative stress was performed by reactive oxygen species (ROS) production via flow cytometry, and the incomprehensible evaluation of ROS‐related genes by RT‐PCR and apoptosis was performed with Annexin‐PI analysis in flow cytometry. The obtained result showed that zoledronic acid inhibited cell viability (IC50 values were determined as 273.16  by MTT) and cell proliferation in a concentration‐dependent manner, induced ROS production, caused glutathione depletion, and increased oxidative stress index and endoplasmic reticulum (ER) stress, indicating severe cellular stress. The expression levels of oxidative damage (L‐fabp, α‐GST, Nrf2, and HMOX1), ER stress (CASP4, IRE1‐α, GADD153, and GRP78), and apoptosis (Bcl‐2, Bax, Cyt‐c, p53, CASP9, CASP3, NF‐κB, TNF‐α, and JNK) related genes were altered as well as IRE1‐α protein levels. Herein, we were the first to show that increased oxidative stress and ER stress resulting in apoptosis are the key molecular pathways in zoledronic acid‐induced nephrotoxicity equivalent to clinically administered concentrations.
Halide‐type Li‐ion conductors: Future options for high‐voltage all‐solid‐state batteries
Authors: Huang Jheng‐Yi , Iputera Kevin , Jena Anirudha , Tong Zizheng , Wei Da‐Hua , Hu Shu‐Fen , Liu Ru‐Shi 
Published: May 2022

AbstractThe design of high‐energy‐density batteries is the future goal of research on Li‐ion batteries. Halide‐type solid‐state electrolytes (SSEs) exceed their counterparts in terms of their stability at high potential. In this minireview, we discuss the developments in the work on halide‐type SSEs for all‐solid‐state Li batteries. In particular, we focus on the Li3InCl6 structure. The effect of synthesis routes on this structure, as well as the convertible products resulting from its phase changes, is discussed. Conductivity can be increased and the electrochemical window can be improved through doping with different materials. Our review aims to provide readers with an overview of the stability and degradation of Li3InCl6 SSE and the structure of halide‐type SSEs (Li–M–X, where M is a metal and X is a halogen).
Dysregulation of the IFN-I signaling pathway byMycobacterium tuberculosisleads to exacerbation of HIV-1 infection of macrophages
Authors: Dupont Maeva , Rousset Stella , Manh Thien-Phong Vu , Monard Sarah Catherine , Pingris Karine , Souriant Shanti , Vahlas Zoï , Velez Tomàs , Poincloux Renaud , Maridonneau-Parini Isabelle , Neyrolles Olivier , Lugo-Villarino Geanncarlo , Vérollet Christel 
Published: May 2022

AbstractWhile tuberculosis (TB) is a risk factor in HIV-1-infected individuals, the mechanisms by which Mycobacterium tuberculosis (Mtb), the agent of TB in humans, worsens HIV-1 pathogenesis still need to be fully elucidated. Recently, we showed that HIV-1 infection and spread are exacerbated in macrophages exposed to TB-associated microenvironments. Transcriptomic analysis of macrophages conditioned with medium of Mtb-infected human macrophages (cmMTB) revealed an up-regulation of the typeI interferon (IFN-I) pathway, characterized by the overexpression of IFN-inducible genes. Historically, IFN-I are well known for their antiviral functions, but our previous work showed that this is not the case in the context of coinfection with HIV-1. Here, we show that the IFN-I response signature in cmMTB-treated macrophages matches the one observed in the blood of active TB patients, and depends on the timing of incubation with cmMTB. This suggests that the timing of macrophage's exposure to IFN-I can impact their capacity to control HIV-1 infection. Strikingly, we found that cmMTB-treated macrophages are hyporesponsive to extrastimulation with exogenous IFN-I, used to mimic HIV-1 infection. Yet, depleting STAT1 by gene silencing to block the IFN-I signaling pathway reduced TB-induced exacerbation of HIV-1 infection. Altogether, by aiming to understand why TB-derived IFN-I preexposure of macrophages did not induce antiviral immunity against HIV-1, we demonstrated that these cells are hyporesponsive to exogenous IFN-I, a phenomenon that prevents macrophage activation against HIV-1.
Development of a highly sensitive glucose nanocomposite biosensor based on recombinant enzyme from corn
Authors: Izadyar Anahita , Van My Ni , Miranda Marcela , Weatherford Scout , Hood Elizabeth E. , Seok Ilwoo 
Published: May 2022

AbstractBACKGROUNDEnzymes are biocatalysts that play a vital role in the production of biomolecules. Plants can be a valuable and cost‐effective source for producing well‐structured recombinant enzymes. Glucose is one of the most important biological molecules, providing energy to most living systems. An electrochemical method for immobilization of enzyme is promising because it is economic, generates less component waste, improves the signal‐to‐noise ratio, leads to a lower limit of detection, and stabilizes and protects the enzyme structure.RESULTSA glucose biosensor was constructed using polyaniline (PANI) and a recombinant enzyme from corn, plant‐produced manganese peroxidase (PPMP), with polymerization of aniline as a monomer in the presence of gold nanoparticles (AuNPs)‐glucose oxidase (GOx), and bovine serum albumin. Using linear sweep voltammetry and cyclic voltammetry techniques, PANI‐AuNPs‐GOx‐PPMP/Au electrode exhibited a superior sensing property with a wider linear range of 0.005–16.0 mm, and a lower detection limit of 0.001 mm compared to PANI‐GOx‐PPMP/Au electrode and PANI‐GOx‐PPMP/AuNPs/Au electrode. The biosensor selectivity was assessed by determining glucose concentrations in the presence of ascorbic acid, dopamine, aspartame, and caffeine.CONCLUSIONWe conclude that a plant‐produced Mn peroxidase enzyme combined with conductive polymers and AuNPs results in a promising nanocomposite biosensor for detecting glucose. The use of such devices for quality control in the food industry can have a significant economic impact. © 2022 Society of Chemical Industry.
Impact of local treatment modality on overall‐ and disease‐specific survival for nonmetastatic pelvic and sacral Ewing sarcoma
Authors: Jawad Muhammad Umar , Pollock Brad H. , Zeitlinger Lauren N. , O'Donnell Edmond F. , Traven Sophia A. , Carr‐Ascher Janai R. , Alvarez Elysia , Malogolowkin Marcio H. , Thorpe Steven W. , Randall R. Lor 
Published: May 2022

AbstractPurposeThe ideal local treatment modality for pelvic and sacral Ewing sarcoma (EWS) is controversial.MethodsWe present the data from the American College of Surgeon's National Cancer Database (NCDB) and the National Cancer Institute's Surveillance, Epidemiology and End Result (SEER) database to investigate the impact of local treatment modalities on survival for nonmetastatic pelvic and sacral Ewing sarcoma. Local treatment includes “surgery,” “radiation,” and a combination of “surgery and radiation.”ResultsA total of 235 cases from SEER and 285 cases from NCDB were analyzed. Patients with “localized” stage (intraosseous) in the SEER database did not show any statistically significant difference in the disease‐specific survival (DSS) for any of the local treatment modalities. Similar findings were observed for overall survival among patients with American Joint Committee on Cancer (AJCC) stage II and III in the NCDB database. However, patients with nonmetastatic disease, particularly regional disease (extraosseous), showed improved DSS with surgery only, in the SEER.ConclusionWe found similar levels of efficacy for different treatment modalities for patients with intraosseous and AJCC II and III pelvic and sacral EWS. “Radiotherapy” is the most common local treatment modality employed in the United States. A prospective, randomized controlled trial with a direct head‐to‐head comparison is needed for a definitive conclusion.
Associations Between Chronic Rhinosinusitis and Cancers: A Nationwide Population‐Based Cohort Study
Authors: Jeon Yung Jin , Joo Yeon‐Hee , Cho Hyun‐Jin , Kim Sang‐Wook , Park Bumjung , Choi Hyo Geun 
Published: May 2022

ObjectiveChronic rhinosinusitis (CRS) is one of the most common chronic inflammatory diseases. The effect of chronic inflammation caused by CRS on the occurrence of various cancers has not been thoroughly evaluated. This study aimed to investigate the increased incidences of 10 types of cancers among CRS patients with/without nasal polyps (NP) using a national population‐based database from the Korean Health Insurance Review and Assessment Service.Study DesignA case–control cohort study.MethodsWe compared the prevalence of various comorbidities between CRS and control participants from a national cohort dataset of the Korean Health Insurance Review and Assessment Service.MethodsCRS participants (n = 6,919) and non‐CRS (n = 27,676) participants were selected from among the 514,866 participants from 2002 to 2015. A stratified Cox proportional hazards model was utilized to assess the hazard ratio (HR) of CRS for 10 types of cancers.ResultsA stratified Cox proportional hazard model demonstrated that the adjusted HR for hematologic malignancy was significantly higher in the CRS patients than in the controls regardless of the presence of NP (2.90 for total CRS; 2.15 for CRS with NP; 4.48 for CRS without NP). The HR for thyroid cancer was significantly higher in the CRS patients without NP but not in those with NP (1.50 for total CRS; 1.78 for CRS without NP).ConclusionThis study showed that CRS participants had a significantly higher prevalence of hematologic malignancy and thyroid cancer.Level of Evidence4 Laryngoscope, 133:1044–1051, 2023
Role of Microbial Metabolites of Histidine in the Development of Colitis
Authors: Wu Jiaqi , Wu Yuzheng , Feng Wen , Chen Qian , Wang Dan , Liu Mengyang , Yu Haiyang , Zhang Yi , Wang Tao 
Published: May 2022

ScopeColitis is a chronic relapsing inflammatory disease of colon. Clinical studies show that meat‐rich diet plays a critical role in the relapse of colitis. However, it is unclear whether the microbial metabolites of histidine, which is an amino acid widely found in meat, have an impact on the health of the intestine.Methods and resultsSix metabolites of histidine are given to IEC‐6 cells. The cell activity measurement shows that imidazole propionate (IMP) is the most detrimental metabolite. Then, IMP is injected to mice by rectal administration, with blood and colon tissues collected for the measurement of colitis related parameters. The results show that treatment with IMP significantly increased NF‐κB, iNOS, and IL‐6, decreased number of goblet cell, and inhibited expressions of miR‐146b. However, overexpression of miR‐146b in mice rescues the decline of the physical condition. Additionally, Notch receptor 1 (Notch1) is identified as a target gene of miR‐146b. Further analysis shows that miR‐146b restored the abundance of goblet cells by regulating Notch1 signaling pathway.ConclusionIMP is able to induce intestinal inflammation, impairs the intestinal barrier, and affects the proliferation of goblet cells. The underlined mechanism may partially contribute to the dysregulation of miR‐146b/Notch1 axis.
Medicine, black magic and supernatural beings: Cultural rituals as a significant threat to slender lorises in India
Authors: Gnanaolivu Smitha D. , Campera Marco , Nekaris K. Anne‐Isola , Nijman Vincent , Satish Roopa , Babu Sharath , Singh Mewa 
Published: May 2022

AbstractTrade of wildlife for use in traditional medicines, rituals, magical spells and cultural practices occurs globally and has been studied mostly in Africa and Asia.The grey slender lorisLoris lydekkerianusis used for both medicinal and ritual purposes, but little information is available on how the user is meant to extract their medicinal properties, or the potential impact these practices have on the species' populations.From 2014–2021, we used open‐ended interviews with 293 informants in three slender loris range states in Southern India to collect qualitative information on people's beliefs regarding the use of slender lorises in traditional medicine, black magic rituals and other cultural practices. To understand this further, we analysed data on 139 live slender loris rescues from three rescue and rehabilitation centres and one government organization in Bengaluru, India collected over an 18‐year period.We found that 116/139 live individuals had been involved in black magic rituals, including piercing, or burning the body and the eyes. These ritual practices occurred more often to female slender lorises and during the new moon. Data from 293 interviews revealed that astrologers regularly use live lorises for fortune‐telling or for warding off evil. Slender loris body parts are used to make traditional folk medicine, develop black magic potions that bring people harm, hypnotize people or to thwart evil.Habitat loss and anthropogenic pressures, coupled with the existing slender loris trade for cultural practices, are a cause for grave concern. Numerous deep‐rooted superstitious beliefs and rituals continue to thrive in modern India, and this is potentially one of the major threats to India's already imperilled slender loris population. More research into the prevalence of loris use for black magic is needed to assess the impact on species sustainability.Read the freePlain Language Summaryfor this article on the Journal blog.
Glycine ester ionic liquid as new co‐initiator used in initiating radical and cationic photopolymerization
Authors: Nan Xuying , Luo Youping , Wu Mingshu , Chen Guangying 
Published: May 2022

AbstractIonic liquids using amino acid ester as cations is a new generation of green ionic liquids. It is found for the first time that they can be used as co‐initiators to initiate radical photopolymerization in the presence of commercial type II sensitizer, camphorquinone (CQ) under mild irradiation conditions. To intensively investigate this new function, we synthesized a series of glycine ester ionic liquids by a very simple method, and then evaluated their performance as co‐initiators in radical photopolymerization. The polymerization studies show that their co‐initiation abilities depend strongly on the structures of N‐terminal substituents and ester groups, as well as the type of anion moiety. And the pH values of the formula also have a heavy influence on their performances. More interestingly, when a small amount of hydroxyethyl acrylate (HEA) was added, under irradiation this multicomponent system composed of CQ, ionic liquids when anion moiety is PF6−, BF4− or SbF6−, and HEA, can release H+ to initiate cationic polymerization. These facts demonstrated that the investigated glycine ester ionic liquids can be considered as valid, environmentally friendly alternatives to toxic aromatic amines co‐initiators. Besides, the corresponding photoinitiation mechanism is suggested.
When you hear hoofbeats, think zebras – pulmonary veno‐occlusive disease: A case report
Authors: Scelsi Laura , Lanzillo Giuseppe , Arbustini Eloisa , D'Armini Andrea , Greco Alessandra , Meloni Federica , Turco Annalisa , Valentini Adele , Oltrona Visconti Luigi , Ghio Stefano 
Published: May 2022

AbstractPulmonary veno‐occlusive disease (PVOD) is a rare disease. It may be idiopathic or associated, in particular, with connective tissue disease, or it may develop after radiation exposure; in heritable forms of PVOD, the inheritance is autosomal recessive due to the presence of homozygous or compound heterozygous pathogenic variants in the EIF2AK4 gene. We describe the case of a young man whose PVOD was initially misdiagnosed as chronic thromboembolic pulmonary hypertension despite worsening after riociguat, nonspecific computed tomography pulmonary angiogram findings, and parental consanguinity could suggest an autosomal recessive disease. The correct diagnosis and the correct treatment are crucial given the high mortality rate of this disease.
Interaction between Cucurbit[7]uril and Bile Salts: An Isothermal Titration Calorimetry Study
Authors: Jana Rabindranath , Ahmed Sayeed Ashique , Seth Debabrata 
Published: May 2022

AbstractThe interaction of three very well‐known bile salts namely sodium deoxycholate (NaDC), sodium cholate (NaC) and sodium taurocholate (NaTC) with cucurbit[7]uril (CB7) have been investigated using isothermal titration calorimetry (ITC). The change in heat during the titration was recorded using microcal ITC200, from which several important thermodynamic parameters of the complexation process like enthalpy, Gibbs free energy, and entropy were obtained with very good precision. The ITC measurement showed that CB7 formed the complex with all the three bile salts at 1 : 1 stoichiometry but with a different binding affinity. The binding affinity of CB7 with the studied bile salts was found to be in the following order NaDC>NaC>NaTC. The overall investigation recommended that the complexation of bile salts with CB7 was highly influenced by both the degree of hydroxylation of bile salt and conjugation in bile salt.