bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Use of Digital Technology to Assess Cognitive Function in Tunisian Adults
Authors: Boujelbane Mohamed Ali , Trabelsi Khaled , Boukhris Omar , Kacem Faten Hadj , Ammar Achraf , Charfi Ichrak , Turki Mouna , Charfeddine Salma , Bouaziz Bassem , Hakim Ahmed , Frikha Hamdi , Chabchoub Mohamed Amine , Chtourou Hamdi , Glenn Jordan M. , Myers Jennifer Rae 
Published: July 2022

Background: There has been increasing evidence and support for the use of digital technology in the cognitive health field. Despite the growing use of innovative digital technology to assess cognitive function, such technology remains scarce in Arabic countries, particularly in Tunisia. Objective: To investigate the effectiveness of a digitally delivered cognitive assessment battery in differentiating varying degrees of cognitive function in older Tunisian adults. Methods: One hundred fifty-five Tunisian older adults (age: 62.24±7.52 years) were assigned to one of four groups: healthy controls (HC), at-risk (AR), mild cognitive impairment (MCI), and Alzheimer’s disease (AD). Participants completed a translated version of the Neurotrack digital cognitive battery. Results: The AD group performed significantly lower on the associative learning ( p = 0.01) and associative memory assessments ( p = 0.002), than the HC and AR groups. The AD group also performed worse on the inhibition measure ( p = 0.008) than the HC, AR, and MCI groups. For recognition memory, the was a significant difference between all four groups ( p < 0.0005), with AD having the lowest scores followed by the MCI, AR, and HC groups, respectively. There were no significant differences observed on attention, executive function and processing speed performance between the four groups ( p > 0.05). Conclusion: The use of digital technology appears to be a viable solution to current cognitive assessment challenges for assessing cognitive function in a Tunisian population. These findings provide further support for the use of digital technology in cognitive assessment, particularly in understudied populations.
MicroRNA-99b-5p targets mTOR/AR axis, induces autophagy and inhibits prostate cancer cell proliferation
Authors: Niture Suryakant , Tricoli Lucas , Qi Qi , Gadi Sashi , Hayes Kala , Kumar Deepak 
Published: July 2022

OBJECTIVES: MicroRNAs (miRNAs) are the small non-coding regulatory RNA molecules involved in gene regulation via base-pairing with complementary sequences in mRNAs. The dysregulation of specific miRNAs, such as miR-99b-5p (miR-99b), is associated with prostate cancer (PCa) progression. However, the mechanistic role of miR-99b in PCa remains to be determined. In this study, we aimed to investigate the functional and clinical significance of miR-99b in PCa. STUDY DESIGN: The expression of miR-99b and its downstream targets mTOR/AR in the PCa samples were analyzed by RT/qPCR. The effects of miR-99b overexpression/inhibition on PCa cell survival/proliferation, spheroid formation, and cell migration were examined by specific assays. Luciferase reporter assays were performed to determine the binding of miR-99b to 3′ untranslated region (UTR) of the mTOR gene. The effects of miR-99b on the expression of mTOR, AR, and PSA proteins, as well as on AKT/mTOR signaling, autophagy, and neuroendocrine differentiation markers were analyzed by western blotting. The expression of miR-99b, mTOR, AR, PSA in AR-negative PC3 and AR-positive LNCaP cells was analyzed by RT/qPCR. The effect of miR-99b on global gene expression in PC3 cells was analyzed by RNA-seq. RESULTS: The expression of miR-99b was downregulated in tumor samples from PCa patients, whereas the expression of mTOR and AR was upregulated. In PCa cell lines, overexpression of miR-99b inhibited cell proliferation and cell colony/spheroid formation; induced apoptosis, and increased sensitivity towards docetaxel (DTX). In contrast, inhibition of miR-99b by miR-99b inhibitor resulted in increased cell growth in PCa cells. Mechanistically, miR-99b inhibited the expression of the mammalian target of the rapamycin (mTOR) gene by binding to its 3′ UTR and induced autophagy. Furthermore, miR-99b inhibited androgen receptor (AR) activity in LNCaP cells and induced apoptosis. Activation of AR signaling by dihydrotestosterone (DHT) downregulated miR-99b expression and promoted cell PCa cell growth/survival, whereas inactivation of mTOR by rapamycin or AR by enzalutamide decreased miR-99b mediated PCa cell growth. CONCLUSION: Our data suggest that miR-99b functions as a tumor suppressor by targeting the mTOR/AR axis in PCa cells, implicating miR-99b as a novel biomarker and therapeutic target for PCa management.
KOMUNIKASI INTERPERSONAL KARYAWAN DALAM MENCIPTAKAN KEPUASAN PELANGGAN
Authors: Faniasari Linda , Manafe Leonard Adrie 
Published: July 2022

ABSTRAK Penelitian ini bertujuan untuk mengetahui pentingnya komunikasi interpersonal Distributor Telur ayam kk dalam menciptakan kepuasan pelanggan. Metode penelitian ini menggunakan pendekatan deskriptif yang dikaji secara kualitatif. Subjek dalam penelitian ini adalah karyawan distributor Telur ayam kk dan sepuluh informan yang merupakan pelanggan dari Distributor telur ayam kk. Teknik pengumpulan data dilakukan melalui wawancara, pengamatan dan dokumentasi. Berdasarkan hasil penelitian ini menunjukkan bahwa komunikasi antar pribadi yang dilihat dari komponen kesetaraan terdapat hambatan komunikasi yaitu: karyawan masih membeda-bedakan pelanggan lama dengan pelanggan baru sehingga menimbulkan ketidaknyamanan dari pelanggan. Sedangkan komunikasi antar pribadi dari komponen keterbukaan, empati, sikap mendukung dan sikap positif sudah berjalan dengan baik dan sesuai dengan apa yang diharapkan oleh pelanggan. Sehingga komunikasi antar pribadi yang baik dapat menjadi faktor penunjang dalam mewujudkan kepuasan pelanggan. Kata-kata Kunci: Komunikasi Interpersonal, Pelayanan, Kepuasan Pelanggan EMPLOYEE INTERPERSONAL COMMUNICATION IN CREATING CUSTOMER SATISFACTION ABSTRACT This study aims to determine the interpersonal communication importance of KK Chicken Egg Distributors in creating customer satisfaction. This research method uses a descriptive approach that is studied qualitatively. The subjects in this study were employees of the KK chicken egg distributor and ten informants who were customers of the KK chicken egg distributor. Data collection techniques were carried out through interviews, observations and documentation. Based on the study results indicate that interpersonal communication seen from the equality component, there are communication barriers, namely: employees still discriminate between old customers and new customers, causing inconvenience to customers. Meanwhile, interpersonal communication from the openness components, empathy, supportive attitude and positive attitude has been going well and in accordance with what is expected by customers. Therefore good interpersonal communication could be a supporting factor in realizing customer satisfaction. Keywords: Interpersonal Communication, Service, Customer Satisfaction
Border Effect and Proximity Effect of Bilateral Trade Between China and Its Land Neighbors — Simulation Based on GTAP Mode
Authors: Zhao Xiaoxue , Xiao Feng 
Published: July 2022

This paper is based on the study of the economic effects of the "six corridors" of China's 14 land neighbors in the "Belt and Road" initiative. A static GTAP model is used to assess the impact of stability and transport infrastructure capacity on the trade potential of China's land neighbors. The study found that the regions with higher stability as a whole have more developed imports and exports. my country's frontier growth is very likely to achieve economies of scale and industrial expansion, driven by policies that focus on improving the level of infrastructure construction.
Model Pembelajaran Kosakata Bahasa Arab di SMK Muhammadiyah Kartasura di Era New Normal Covid-19
Authors: Priwitasari Ashlih 
Published: July 2022

Learn arabic vocabulary at the Muhammadiyah Vocational School Kartasura offline or face-to-face with students in the class, Arabic teacher's using direct model for teach in front of students in classroom. Steps of learning arabic vocabulary model in Muhammadiyah Vocational School Kartasura is teacher writes the vocabulary on the board, teacher reads the Arabic vocabulary in front of the students and asks students to repeat the reading of the vocabulary on the board, the students write the new vocabulary in the notebook, the teacher asks the students to memorize the vocabulary, teacher asks students to advance one by one, saying the vocabulary they have memorized. Sometimes, teacher gives material to support students in making the sentences because students were not able to form the sentences correctly.
MONTEIRO LOBATO E A COMIDA DO VALE DO PARAÍBA PAULISTA
Authors: Faria Aline Liz , Rodrigues Alexandra Magna , Chamon Edna Maria Querido , Leão Marluce Auxiliadora Borges Glaus 
Published: July 2022

O objetivo deste artigo é compreender o contexto geográfico e social no qual Monteiro Lobato estava inserido e a cultura e tradição culinária da região do Vale do Paraíba Paulista em sua época. A presente pesquisa é um recorte da dissertação de mestrado “FAZER, COMER E AMAR: Representações Sociais de idosos sobre a comida na infância” que por tratar de questões relacionadas às memórias sobre a comida para idosos nascidos no Vale do Paraíba Paulista , discutiu aspectos culturais e literários desse objeto.
Este estudo demonstrou por meio do objeto social a comida, sua ação comunicativa, qual Monteiro Lobato, utilizava para retratar a sociedade da época, com seus hábitos e costumes. Além disso, a valorização dos saberes e sabores regionais do Vale do Paraíba Paulista, contidos em seus livros e contos.
Upaya Meningkatkan Prestasi Belajar Matematika Dengan Menggunakan Alat Peraga
Authors: Ayang Ayang 
Published: July 2022

Media pembelajaran meliputi yang berupa sarana, prasarana, dan fasilitas yang dapat digunakan untuk menyampaikan pesan atau bahan pelajaran kepada subyek didik untuk memperjelas, memperlancar, dan lebih meningkatkan dan efektifitas dalam proses pembelajaran digunakan media pengajaran. Tujuan dari penelitian ini adalah untuk mengetahui meningkatnya prestasi belajar matematika pada aspek bilangan pecahan dalam pembelajaran dengan menggunakan alat peraga pada siswa kelas III SDN Kuluk Bali.
Tempat penelitian tindakan kelas ini adalah di SDN Kuluk Bali. Tempat penelitian berlokasi di SDN Kuluk Bali, dimana tempat ini sekaligus tempat penulis melaksanakan tugas mengajar. Sampel yang penulis pergunakan dalam penelitian ini adalah seluruh siswa kelas III SDN Kuluk Bali yang terdiri 41 siswa. Nilai rata prestasi belajar Matematika siswa kelas III pada siklus I sebesar 67, pada siklus II sebesar 76 sehingga terdapat kenaikan nilai rata-rata dari siklus I ke siklus II. Prosentase ketuntasan belajar siswa pada siklus I menunjukkan angka sebesar 60,97 % ( 25 siswa tuntas dalam belajarnya dari seluruh peserta 41 siswa), pada siklus II sebesar 97,6 % (40 siswa tuntas dalam belajarnya dari seluruh peserta 41 siswa). Dengan demikian terdapat peningkatan ketuntasan belajar siswa dari siklus I ke siklus II.
Peningkatan Kemampuan Menulis Teks Recount Melalui Kegiatan Menulis Berantai
Authors: Maskuyandi Maskuyandi 
Published: July 2022

Menulis teks recount adalah kemampuan yang wajib dikuasai oleh siswa. Faktanya banyak siswa yang memiliki masalah di dalamnya. Masalah mereka diantaranya adalah penemuan dan pengembangan ide, membuat kalimat yang benar, menggunakan kosa kata yang baik. Menulis berantai adalah kegiatan menulis dengan menghubungkan satu ide ke ide lainnya. Proses ini dilakukan dengan menghubungkan ide seseorang dengan yang lain dalam kegiatan berpasangan atau kelompok. Penelitian Tindakan Kelas (PTK) ini bertujuan untuk meningkatkan hasil belajar siswa kelas VIII-B SMPN 8 Dusun Selatan dalam pembelajaran Bahasa Inggris. PTK ini terdiri dari 2 siklus, dengan tiap-tiap siklus memuat tahap perencanaan, tindakan, observasi, dan refleksi. Objek tindakan yang diteliti meliputi kreativitas dan kompetensi berbicara bahasa Inggris siswa pada tiap-tiap siklus.
Data yang dikumpulkan adalah data kreativitas siswa selama mengikuti proses pembelajaran dan data kompetensi berbicara bahasa Inggris siswa pada akhir tiap-tiap siklus penelitian. Data kreativitas siswa diperoleh dengan cara melakukan observasi atau pengamatan terhadap aktivitas siswa selama proses pembelajaran, dengan menggunakan lembar observasi. Sedang data hasil belajar siswa diperoleh dengan melakukan tes hasil belajar, dengan soal tes tertulis berbentuk uraian. Data hasil observasi pembelajaran dianalisis bersama-sama dengan mitra kolaborasi, kemudian ditafsirkan berdasarkan kajian pustaka dan pengalaman guru peneliti dan guru mitra. Sedangkan hasil belajar siswa dianalisis berdasarkan ketentuan ketuntasan belajar, yaitu dengan membandingkan nilai yang diperoleh siswa dengan KKM. Dalam penelitian ini ditetapkan nilai KKM adalah 68. Seorang siswa dinyatakan mencapai ketuntasan belajar jika memperoleh nilai lebih dari atau sama dengan 68.Hasil penelitian menunjukkan siswa mampu mendapatkan ide dengan lebih mudah setelah mengikuti kegiatan menulis berantai. Mereka juga lebih mudah mengembangkan ide tersebut dalam sebuah teks recount.
Implementasi Lesson Study Dalam Meningkatkan Profesionalisme Guru
Authors: Norhanah Norhanah 
Published: July 2022

Lesson study sebagai salah satu program kegiatan untuk meningkatkan kompetensi guru dan kualitas pembelajaran dapat dikembangkan di sekolah sebagai studi untuk analisis atas suatu praktik pembelajaran yang dilaksanakan dalam bentuk pembelajaran berbasis riset untuk menemukan inovasi pembelajaran tertentu.
Subjek penelitian tindakan sekolah ini adalah guru SMPN 5 Dusun Selatan Barito Selatan yang berjumlah 16 guru PNS. Namun karena keterbatasan waktu dan tenaga, maka diambil 10 orang sebagai sampel. Sedangkan waktu pelaksanaan penelitian tindakan sekolah ini dilakukan pada Januari sampai dengan Juni 2021 selama 2 siklus yang mana masing-masing siklus dilaksanakan dua kali pertemuan.
Hasil penelitian, penulis dapat membuat suatu kesimpulan sebagai berikut : Pelaksanaan Lesson Study di SMPN 5 Dusun Selatan Barito Selatan pada awalnya menemui hambatan yang cukup berarti. Namun setelah dilaksanakan refleksi dapat berjalan secara baik dan efektif. Profesionalisme guru SMPN 5 Dusun Selatan Barito Selatan semakin baik, setelah dilaksanakan lesson study. Berdasarkan hasil siklus I, nilai rata-rata lesson study sejumlah 2,84 kemudian mengalami peningkatan pada siklus II menjadi 3,15. Dengan demikian pelaksanaan Lesson Study dapat meningkatkan profesionalisme guru SMPN 5 Dusun Selatan Barito Selatan.
Diagnóstico de la situación de la distribución comercial de los alojamientos turísticos privados del Consejo Popular Vedado, en vista a un escenario post COVID-19
Authors: Vidal Díaz Daniela , Valdivia Izquierdo Sergio , Díaz Medina Antonio , Vidal Díaz Dayana 
Published: July 2022

Los Bed and Breakfast se han convertido en una tipología de alojamiento cada vez más popular entre los viajeros que no desean permanecer en hoteles convencionales y buscan compartir las costumbres locales, en el caso de Cuba se les conoce como alojamientos privados. Para el sistema turístico del Consejo Popular Vedado esta alternativa de hospedaje ha cobrado un gran auge durante los últimos años contribuyendo a diversificar la oferta alojativa del país, no obstante hace ya más de un año la situación de este sector ha sido compleja por el impacto de la pandemia de la COVID-19. Por tanto, el objetivo de la presente investigación fue diagnosticar la situación de la distribución comercial de los alojamientos privados en el Vedado en vista a un escenario post COVID-19. Para dar cumplimiento al mismo se desarrolló un amplio trabajo de campo que conllevó a la aplicación de técnicas de investigación, tales como encuestas a arrendadores y entrevistas a expertos del tema, lo que permitió dilucidar la situación de la distribución comercial de los alojamientos privados del territorio objeto de estudio.
Comunicación Intercultural e Interpretación del Patrimonio: Papel del Guía de Turismo ante la Mediación
Authors: Morales Domínguez Alberto Alejandro 
Published: July 2022

El presente estudio indaga acerca del tratamiento de determinadas situaciones interculturales en el marco de la interpretación del patrimonio que realizan nuestros guías turísticos. Su objetivo se centra en la creación de un entrenamiento para promover la competencia intercultural. Se comienza con una discusión sobre del papel del guía de turismo ante la mediación en el escenario intercultural. Se considera que el desarrollo de esta competencia no ha sido suficientemente estudiado en cursos de capacitación de los guías de turismo. Es pertinente rediseñar un entrenamiento a distancia para el desarrollo de la competencia intercultural en guías turísticos y hacer uso de la teoría de la mediación en su contexto profesional. El trabajo consideró una nueva definición de competencia intercultural. Su fomento será sustentada en un entrenamiento en el marco de la interpretación de patrimonio.
Efektivitas Video Pembelajaran Berbasis Zenius.Net Dalam Meningkatkan Pemahaman Konsep Kimia Siswa
Authors: Safitri Baiq Rina Amalia , Pahriah Pahriah , Fuaddunnazmi Muhammad 
Published: July 2022

This research has a core objective, namely to find out the effectiveness of the application of Zenius-based learning videos in improving students' understanding of chemical concepts. This research is included in the category of experimental type quantitative research. Meanwhile, the research method chosen was One Group Pretest-Posttest Design, which means that only one research group was used. A total of 17 students were selected from class X and XI MA Anshor Beber as the research population using saturated sampling technique or population research. The data analysis technique used in this study combines descriptive data analysis for the measurement of the mean and inferential statistics for testing the significance of the t-test value. The significance of the Ngain value was tested using a t-test (paired samples t-test) and the results were used to interpret the extent of students' understanding of chemical concepts. The average N-gain of students' conceptual understanding after the application of Zenius-based learning videos is 0.7 with a medium category. The average understanding of students' concepts after treatment (77) was proven to be significantly greater than before being given treatment (34) based on the value of t count = 28.8 which was greater than tcritical = 2.1 for dk = 15 with a p significance value of 0.000. Therefore, it can be concluded that zenius.net-based learning videos are effective in increasing students' understanding of concepts.
An ANALYSIS OF STUDENTS' ERROR IN USING PASSIVE VOICE
Authors: Yoga Widiadnya I Gusti Ngurah Bagus , Lestari I Gusti Ayu Agung Yuni 
Published: July 2022

Abstract: This research aimed to find out the errors made by the tenth-grade students of Smk Nusa Dua especially first grade students of hotel accommodation program in using passive voice. This purposed of this research is to find out the types of errors. The researcher used Dulays’ theory to find the types of error. Furthermore, the researcher used descriptive qualitative research design. To get the sample, the researcher used cluster sampling technique. The researcher took 45 students as a sample from class 10 AP2. To analysis the data, the researcher gave a test about passive voice of simple present tense. There were totally 352 errors created by the students. Those errors derived from omission with 21 errors, addition with 67 errors, misformation with 253 errors and misordering with 11 errors.
EKSPRESI IDEALIS PEMERAN UTAMA DALAM NOVEL TUHAN, IZINKAN AKU MENJADI PELACUR KARYA MUHIDIN M. DAHLAN
Authors: Muhsyanur Muhsyanur 
Published: July 2022

Penelitian ini pada dasarnya bertujuan mendeskripsikan ekspresi idealis pemeran utama dalam novel Tuhan, Izinkan Aku Menjadi Pelacur karya Muhidin M. Dahlan. Penelitian ini termasuk penelitian kualitatif dengan menerapkan metode deskriptif. Sumber data penelitian yakni novel Tuhan, Izinkan Aku Menjadi Pelacur karya Muhidin M. Dahlan, dengan data penelitian berupa kata, frasa, kalimat dan pernyataan yang ekspresi idealis. Data penelitian dikumpulkan dengan teknik baca secara intensif dan sistem penandaan. Teknik analisis yang digunakan dalam penelitian ini ialah teknik hermeneutika. Hasil penelitian ini menunjukkan bahwa ekspresi idealis pemeran utama dalam novel Tuhan, Izinkan Aku Menjadi Pelacur karya Muhidin M. Dahlan mencakup (1) ambisius, (2) teguh pada pendirian, dan (3) optimisme. Penelitian ini dapat dimanfaatkan, baik secara teoretis maupun praktis. Secara teoretis, penelitian ini dapat mengembangkan teori-teori sastra khususnya sastra Indonesia. Secara praktis, penelitian ini dapat dimanfaatkan bagi peneliti, guru, dan mahasiswa sebagai referensi dan rujukan untuk penelitian selanjutnya.
The Gastrointestinal Load of Carbapenem-Resistant Enterobacteriacea Is Associated With the Transition From Colonization to Infection by Klebsiella pneumoniae Isolates Harboring the blaKPC Gene
Authors: Migliorini Letícia Busato , Leaden Laura , de Sales Romário Oliveira , Correa Nathalia Pellegrini , Marins Maryana Mara , Koga Paula Célia Mariko , Toniolo Alexandra do Rosario , de Menezes Fernando Gatti , Martino Marines Dalla Valle , Mingorance Jesús , Severino Patricia 
Published: July 2022

BackgroundHealthcare-associated infections by carbapenem-resistant Klebsiella pneumoniae are difficult to control. Virulence and antibiotic resistance genes contribute to infection, but the mechanisms associated with the transition from colonization to infection remain unclear.ObjectiveWe investigated the transition from carriage to infection by K. pneumoniae isolates carrying the K. pneumoniae carbapenemase–encoding gene blaKPC (KpKPC).MethodsKpKPC isolates detected within a 10-year period in a single tertiary-care hospital were characterized by pulsed-field gel electrophoresis (PFGE), multilocus sequencing typing, capsular lipopolysaccharide and polysaccharide typing, antimicrobial susceptibility profiles, and the presence of virulence genes. The gastrointestinal load of carbapenem-resistant Enterobacteriaceae and of blaKPC-carrying bacteria was estimated by relative quantification in rectal swabs. Results were evaluated as contributors to the progression from carriage to infection.ResultsNo PGFE type; ST-, K-, or O-serotypes; antimicrobial susceptibility profiles; or the presence of virulence markers, such yersiniabactin and colibactin, were associated with carriage or infection, with ST437 and ST11 being the most prevalent clones. Admission to intensive and semi-intensive care units was a risk factor for the development of infections (OR 2.79, 95% CI 1.375 to 5.687, P=0.005), but higher intestinal loads of carbapenem-resistant Enterobacteriaceae or of blaKPC-carrying bacteria were the only factors associated with the transition from colonization to infection in this cohort (OR 8.601, 95% CI 2.44 to 30.352, P&lt;0.001).ConclusionThe presence of resistance and virulence mechanisms were not associated with progression from colonization to infection, while intestinal colonization by carbapenem-resistant Enterobacteriacea and, more specifically, the load of gastrointestinal carriage emerged as an important determinant of infection.