bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategi Bisnis yang Harus Dipahami oleh Pengusaha
Authors: Sawitri Pane Mutiara , M. Nawawi Zuhrinal 
Published: August 2022

As an entrepreneur, it is necessary for him to have knowledge related to strategies in running his business. Because by making the right strategy, he will benefit as expected, and vice versa with the wrong strategy will cause losses for business owners and even allow entrepreneurs to go bankrupt. Of course, every entrepreneur does not want to experience bankruptcy or big losses. For this reason, it is necessary for entrepreneurs to understand strategies in doing business as a way to achieve success. This study will explain the various strategies that entrepreneurs need to know in running their business. The method used in explaining the entrepreneur's strategy is descriptive qualitative in which the researcher will conduct a literature study to produce various references related to the strategies that entrepreneurs can go through to run their business. This research explains that there are many strategies that entrepreneurs can go through, including through digital, considering that today is thick with the digital world, so as an entrepreneur he will continue to run a business that can be reached by the younger generation because their world is generally through digital as a means of communication.
Keywords: entrepreneur, business, digital, strategy
Evaluasi Kelayakan Finansial Pasar Bareng Kota Malang Hasil Revitalisasi Sebagai Pasar Multifungsi
Authors: Nasikh Nasikh , Rahardjo Andhika Widianto 
Published: August 2022

In realizing the economic growth of a region, many aspects need to be considered. One of the two aspects in realizing positive economic growth of a region is infrastructure and trade. The development of an infrastructure or project needs to cost money, moreover the project is not a small project. Therefore, there needs to be an in-depth and structured study and research before the project is funded or has been funded so as to know the prospects of the project. The study and research used an analysis of the financial feasibility study for the development of Pasar Bareng in Malang City with the aim of seeing the financial feasibility of developing Pasar Bareng. A project feasibility study has the meaning of a study that can see if the project if it gets an investment can run well and provide financial benefits. This study uses the Net Present Value (NPV), Internal Rate of Return (IRR), and Benefit Cost Ratio (BCR) methods. The data that has been collected will be analyzed and get a project development perspective from a financial perspective. In this study there is a comparison of profit or loss obtained by looking at data from operational costs, income, and investment costs. The costs used come from maintenance and operational costs incurred during the operation of Pasar Bareng. The results of the feasibility analysis test using the Net Present Value method get a value of Rp. – 7,000,291,269,823. Then, the Benefit Cost Ratio method gets a value of Rp. 0,000,039,423,147. And the last method is the Internal Rate of Return method which gets a value of -1,373,149.77. From the results of this analysis, it can be concluded that the development of Pasar Bareng Malang City is not feasible to do.
Key words: Feasibility Study, Pasar Bareng, Malang City.
Analisis Keputusan Calon Nasabah Memilih Produk Asuransi Prucinta di PT Prudential Life Assurance Binjai
Authors: Yusrizal Yusrizal , Ritonga Sonia 
Published: August 2022

The decision of a prospective customer to choose a product is a decision-making process that begins with the introduction of needs from various options then evaluates them and decides on a choice of a product from many choices.So the decision of a prospective customer in choosing a product is a process that is carried out by a prospective customer when choosing the product, then the prospective customer chooses one of the products from the existing product choices. so that there are no good obstacles that the decisions taken can have effects and cause problems in other fields so that when making decisions, one must be careful in life assurance at the Binjai branch, including products, prices, locations and places where people promote Prucinta products to achieve sales targets for agents or marketers will carry out the prospect of a product presentation fact-finding approach and closing or closing
Keywords : prospective customer decisions, the importance of decisions, prucinta products
Identifikasi Kualitas Kesegaran Susu Kambing Melalui Pengolahan Citra Digital Menggunakan Metode Learning Vector Quantization (LVQ)
Authors: Parahana Dea Parahana 
Published: August 2022

Goat milk is milk produced by female goats after giving birth. Goat's milk contains many vitamins, minerals, electrolytes, chemical elements, enzymes, proteins, and fatty acids that are good for body health. The number of people's interest in goat's milk, makes goat's milk farmers to produce goat's milk in various ways for the sake of profit. For example, by reducing the level of purity and freshness of goat's milk by mixing other ingredients other than the original pure goat's milk. The identification process using imagery requires a method that can identify fresh and not fresh goat's milk. There are several methods that can be applied in digital image processing, one of which is using the Learning Vector Quantization (LVQ) method. LVQ is a single layer net with each input layer connected directly to the output neurons. Both are associated with a weight consisting of xi is the input, wii is the weight and yi is the output. Analysis of this calculation is used which becomes the initial value. Learning Rate (α) = 0.05, with a reduction of 0.1 * , and maximum epoch (MaxEpoch) = 1. The results of the analysis of the smallest distance on the 1st weight, so that the input image of the goat's milk test belongs to class 2. Thus, the image data of the goat's milk test is identified as mixed goat's milk.
Keywords: Goat's Milk, Digital Image, Learning Vector Quantization
Optimised bumblebee paths as search strategy for autonomous underwater vehicles
Authors: Tholen Christoph , Nolle Lars , El-Mihoub Tarek A. , Zielinksi Oliver 
Published: August 2022

In this paper, the concept of optimized bumblebee (BB) patterns as a search strategy for autonomous underwater vehicles (AUV) is presented. Here, an AUV is used to detect submarine groundwater discharge (SGD) in coastal areas. The optimization of the BB paths is achieved utilizing k-opt optimization. In this research, 2-opt, 3-opt and 4-opt is used for the optimization of the BB paths. It is shown using computer simulations that all three optimization strategies are able to improve the search capabilities of the BB search strategy. The optimization of the BB path shortens the length of the path to visit the waypoints generated. The saved energy can be used for exploring. The median saved path length is 33.8 m, 43.5 m and 52.6 m for the 2-opt, 3-opt and 4-opt, respectively. The median error over 1,000 experiments of the not-optimized BB is 76.26, while the median error of the optimized BB are 71.63, 72.02 and 72.23 for the 2-opt, 3-opt and 4-opt, respectively.
Application of the Extended Finite Element Method in the Aim of Examination of Crack Propagation in Railway Rails
Authors: Bobis Daniel , Zwierczyk Peter T. , Mate Tamas 
Published: August 2022

In this research, a rolling contact fatigue (RCF) caused crack the so-called head check (HC) was studied by the extended finite element method (X-FEM). The formation and treatment of these cracks is a major problem in the railway industry worldwide. The study aimed to explore the capabilities of the X-FEM concerning examinations of crack propagation in rolling contact conditions. The paper introduces the X-FEM from a practical point of view, with an emphasis on the application of the method, rather than focusing on the exact values. Results showed that the method can be used adequately for such complex issues as examination of crack propagation. However, the possibilities of this technique are quite limited in practice yet due to technical reasons.
Principles of journalistic ethics in the publications of Spanish newspapers (on the example of "ABC", "El Pais", "El Mundo", "La Vanguardia")
Authors: Kuz'mich Stanislav Valer'evich 
Published: August 2022

The subject of this study is the implementation of the principles of journalistic ethics in modern Spanish newspapers. The purpose of the study is to identify the level of compliance with journalistic ethics in the publications of the newspapers "ABC", "El Pais", "El Mundo", "La Vanguardia". The author notes that the greatest compliance with the principles of professional ethics is noted by readers of the newspaper "ABC". The research methodology is based on a systematic approach and includes the following methods: analysis of scientific literature on the research topic; content analysis of publications "ABC", "El Pais", "El Mundo", "La Vanguardia"; method of sociological questioning (mini-survey); method of statistical analysis; method of comparative analysis of the obtained results. As a result of this study, we obtained the following results: the level of compliance with the principles of journalistic ethics of each newspaper was revealed based on the data obtained from a mini-survey among Spanish-speaking readers. The areas of application of the results can be such as "ethics of professional activity", "political journalism", "international journalism". The novelty of this study lies in the methodology proposed by the author for analyzing the level of compliance with the principles of journalistic ethics. The author of the article came to the following conclusions: modern Spanish newspapers are characterized by a high level of compliance with journalistic ethics, except for the newspaper "La Vanguardia" (average level according to readers).
Long Days, Short Years
Authors: Bomback Andrew 
Published: August 2022

How parenting became a verb, from Dr. Spock and June Cleaver to baby whispering and free-range kids.
When did “parenting” become a verb? Why is it so hard to parent, and so rife with the possibility of failure? Sitcom families of the past—the Cleavers, the Bradys, the Conners—didn't seem to lose any sleep over their parenting methods. Today, parents are likely to be up late, doomscrolling on parenting websites. In Long Days, Short Years, Andrew Bomback—physician, writer, and father of three young children—looks at why it can be so much fun to be a parent but, at the same time, so frustrating and difficult to parent. It's not a “how to” book (although Bomback has read plenty of these) but a “how come” book, investigating the emergence of an immersive, all-in approach to raising children that has made parenting a competitive (and often not very enjoyable) sport.
Drawing on parenting books, mommy blogs, and historical accounts of parental duties as well as novels, films, podcasts, television shows, and his own experiences as a parent, Bomback charts the cultural history of parenting as a skill to be mastered, from the laid-back Dr. Spock's 1950s childcare bible—in some years outsold only by the actual Bible—to the more rigid training schedules of Babywise. Along the way, he considers the high costs of commercialized parenting (from the babymoon on), the pressure on mothers to have it all (and do it all), scripted parenting as laid out in How to Talk So Kids Will Listen, parenting during a pandemic, and much more.
Incidence of hemoparasitic infections in cattle from central and northern Thailand
Authors: Koonyosying Pongpisid , Rittipornlertrak Amarin , Chomjit Paweena , Sangkakam Kanokwan , Muenthaisong Anucha , Nambooppha Boondarika , Srisawat Wanwisa , Apinda Nisachon , Singhla Tawatchai , Sthitmatee Nattawooti 
Published: August 2022

Background
Hemoparasites, such as Babesia spp., Theileria spp. and Anaplasma spp., can negatively affect the health of farm animals resulting in significant losses in production. These losses inherently affect the economics of the livestock industry. Since increases in the severity of vector-borne diseases in the southeast Asian region have been reported, investigations of parasitic epidemiology in Thailand will be necessary to improve the existing parasite control strategies for blood parasitic infections. This study aims to investigate incidences of bovine hemoparasites throughout central and northern Thailand by focusing on areas of high-density cattle populations.

Methods
Blood parasitic infections among cattle were screened and identified by microscopic examination. Anemia status was then determined by evaluation of the packed cell volume (PCV) of each animal. Furthermore, blood parasites were detected and identified by genus and species-specific primers through the polymerase chain reaction method. Amplicons were subjected to DNA sequencing; thereafter, phylogenetic trees were constructed to determine the genetic diversity and relationships of the parasite in each area.

Results
A total of 1,066 blood samples were found to be positive for blood parasitic infections as follows: 13 (1.22%), 389 (36.50%), and 364 (34.15%) for Babesia bovis, Theileria orientalis, and Anaplasma marginale, respectively. Furthermore, multiple hemoparasitic infections in the cattle were detected. The hematocrit results revealed 161 hemoparasitic infected samples from 965 blood samples, all of which exhibiting indications of anemia with no significant differences. Sequence analysis of the identified isolates in this study revealed that B. bovis rap-1, four separate clades of T. orientalis msps, and A. marginale msp4 exhibited considerable sequence similarity to homologous sequences from isolates obtained from other countries. Sequence similarity ranged between 98.57–100%, 83.96–100%, and 97.60–100% for B. bovis rap-1, T. orientalis msps, and A. marginale msp4, respectively.

Conclusion
In this study, the analyzed incidence data of cattle hemoparasitic infection in Thailand has provided valuable and basic information for the adaptation of blood-borne parasitic infections control strategies. Moreover, the data obtained from this study would be useful for future effective parasitic disease prevention and surveillance among cattle.
MEMÓRIA COMO EXPRESSÃO ATÁVICA DO TERRITÓRIO EM ESPAÇO TERRESTRE, DE GILVAN LEMOS
Authors: Santos Anderson Felix , Holanda Lourival 
Published: August 2022

O artigo analisa a relação atávica entre memória e território no romance Espaço Terrestre, de Gilvan Lemos, baseado, sobretudo, nas teorias de Glissant (2005) e Candau (2016). O objetivo foi verificar como as memórias dos personagens do grupo familiar dos Albanos se perpetuam ao longo do enredo e como se relacionam com a gênese da cidade ficcional de Sulidade. Como resultado, se constatou que a fundação da cidade é o mito norteador para a génese de uma memória atávica que se perpetuará juntamente com a memória familiar, pois nela viveram todos os membros, ascendentes e descendentes e nela construíram a história da estirpe
Understanding Flares in Patients With Generalized Pustular Psoriasis Documented in US Electronic Health Records
Authors: Zema Carla L. , Valdecantos Wendell C. , Weiss Jonathan , Krebs Blake , Menter Alan M. 
Published: August 2022

ImportanceOther than single-center case studies, little is known about generalized pustular psoriasis (GPP) flares.ObjectiveTo assess GPP flares and their treatment, as well as differences between patients with and patients without flares documented in US electronic health records (EHRs).Design, Setting, and ParticipantsThis retrospective cohort study included adult patients with GPP (International Statistical Classification of Diseases and Related Health Problems, Tenth Revisioncode L40.1) identified in Optum deidentified EHR data between July 1, 2015, and June 30, 2020. The index GPP diagnosis was the first occurrence in the EHR, with no coded history of GPP for at least 6 months prior. Flare episodes were identified using an algorithm based on diagnosis coding, care setting, type of clinician, GPP disease terms, and flare terms and attributes in the EHR.Main Outcomes and MeasuresFlare episodes were characterized by the frequency of occurrence per patient, the care setting in which they were identified, the type of specialist managing the episode, associated symptoms, and the type of treatment before, during, and after the episode. Patients were divided into groups based on whether or not they had a flare episode documented in their EHR. Comparisons were made between the groups based on demographic characteristics, comorbidity burden, health care use, and treatments.ResultsOf 1535 patients with GPP (1018 women [66.3%]; mean [SD] age, 53.4 [14.7] years), 271 had 513 flares documented. Compared with patients without flares, patients with flares had a 34% higher mean (SD) Charlson Comorbidity Index score (2.80 [3.11] vs 2.09 [2.52]), were almost 3 times more likely to have inpatient visits (119 of 271 [44%] vs 194 of 1264 [15%]), were more than twice as likely to have emergency department (ED) visits (126 of 271 [47%] vs 299 of 1264 [24%]), and had higher use of almost all treatment classes. Flares were identified in outpatient (271 of 513 [53%]), inpatient (186 of 513 [36%]), and ED (48 of 513 [9%]) settings. The most common treatments during flares were topical corticosteroids (35% of episodes [178 of 513]), opioids (21% [106 of 513]), other oral treatments, (eg, methotrexate, cyclosporine, tacrolimus; 13% [67 of 513]), and oral corticosteroids (11% [54 of 513]). Almost one-fourth of flare episodes (24% [122 of 513]) had no dermatologic treatment 30 days before, during, or 30 days after a flare episode.Conclusions and RelevanceThis cohort study suggests that there is significant unmet need for the treatment of GPP and its flares, as evidenced by patients seeking treatment in inpatient and ED settings, as well as the lack of advanced treatments.
A Combinatorial Library of Biodegradable Lipid Nanoparticles Preferentially Deliver mRNA into Tumor Cells to Block Mutant RAS Signaling
Authors: Cai Weiqi , Luo Tianli , Chen Xianghan , Mao Lanqun , Wang Ming 
Published: August 2022

AbstractMessenger RNA (mRNA) is an emerging class of biotherapeutics for vaccine development and genome editing. Efficacious delivery and control of mRNA functionality selectively to disease cells remains the major challenge in developing mRNA therapeutics. Herein, reactive oxygen species (ROS)‐degradable lipid nanoparticles containing a thioketal (TK) moiety to deliver mRNA into cells are reported, selectively releasing mRNA in tumor cells for enhanced gene expression. By screening a library of parallelly synthesized ROS‐degradable lipids, it has been identified that BAmP‐TK‐12 delivers mRNA one‐fold more potent in tumor cells than in non‐cancerous cells. Furthermore, the delivery of mRNA encoding DUF5, a bacterial‐derived RAS protease using BAmP‐TK‐12 enables generic depletion of mutant RAS of tumor cells, showing a significantly improved antitumor effect than small molecule‐based RAS inhibitor. It has been believed that the strategy of tumor cell‐selective mRNA delivery using ROS‐degradable lipid nanoparticles can be expanded to the broad range of bacterial effectors for rewiring cancer cell signaling and developing advanced biotherapeutics.
A Bio‐Based Supramolecular Adhesive: Ultra‐High Adhesion Strengths at both Ambient and Cryogenic Temperatures and Excellent Multi‐Reusability
Authors: Sun Peng , Mei Shan , Xu Jiang‐Fei , Zhang Xi 
Published: August 2022

AbstractDeveloping high‐performance and reusable adhesives from renewable feedstocks is of significance to sustainable development, yet it still remains a formidable task. Herein, castor oil, melevodopa, and iron ions are used as building blocks to construct a novel bio‐based supramolecular adhesive (BSA) with outstanding adhesion performances. It is prepared through partial coordination between melevodopa functionalized castor oil and Fe3+ ions. Noncovalent interactions between adherends and the catechol unit from melevodopa contribute to reinforcing adhesion, and the metal‐ligand coordination between catechol and Fe3+ ions is utilized to strengthen cohesion. By combining strong adhesion and tough cohesion, the prepared BSA achieves an adhesion strength of 14.6 MPa at ambient temperature, a record‐high value among reported bio‐based adhesives as well as supramolecular adhesives to the best of knowledge. It also outperforms those adhesives at cryogenic temperature, realizing another record‐high adhesion strength of 9.5 MPa at −196 °C. In addition, the BSA displays excellent multi‐reusability with more than 87% of the original adhesion strength remaining even after reuse for ten times. It is highly anticipated that this line of research will provide a new insight into designing bio‐based adhesives with outstanding adhesion performances and excellent multi‐reusability.
Can tandem alternative splicing and evasion of premature termination codon surveillance contribute to attenuated Peutz–Jeghers syndrome?
Authors: Gazzaz Nour , Frost F. Graeme , Alderman Emily , Richmond Phillip A. , Dalmann Joshua , Lin Susan , Salman Areesha , Del Bel Kate L. , Lehman Anna , Turvey Stuart E. , Boerkoel Cornelius F. , Cherukuri Praveen F. 
Published: August 2022

AbstractAlternative use of short distance tandem sites such as NAGNnAG are a common mechanism of alternative splicing; however, single nucleotide variants are rarely reported as likely to generate or to disrupt tandem splice sites. We identify a pathogenic intron 5 STK11 variant (NM_000455.4:c.[735‐6A>G];[=]) segregating with the mucocutaneous features but not the hamartomatous polyps of Peutz–Jeghers syndrome in two individuals. By RNAseq analysis of peripheral blood mRNA, this variant was shown to generate a novel and preferentially used tandem proximal splice acceptor (AAGTGAAG). The variant transcript (NM_000455.4:c.734_734 + 1insTGAAG), which encodes a frameshift (p.[Tyr246Glufs*43]) constituted 36%–43% of STK11 transcripts suggesting partial escape from nonsense mediated mRNA decay and translation of a truncated protein. A review of the ClinVar database identified other similar variants. We suggest that nucleotide changes creating or disrupting tandem alternative splice sites are a pertinent disease mechanism and require contextualization for clinical reporting. Additionally, we hypothesize that some pathogenic STK11 variants cause an attenuated phenotype.
Recommendations to address key recruitment challenges of Alzheimer's disease clinical trials
Authors: Langbaum Jessica B. , Zissimopoulos Julie , Au Rhoda , Bose Niranjan , Edgar Chris J. , Ehrenberg Evan , Fillit Howard , Hill Carl V. , Hughes Lynne , Irizarry Michael , Kremen Sarah , Lakdawalla Darius , Lynn Nancy , Malzbender Kristina , Maruyama Tetsuyuki , Massett Holly A. , Patel Deep , Peneva Desi , Reiman Eric M. , Romero Klaus , Routledge Carol , Weiner Michael W. , Weninger Stacie , Aisen Paul S. 
Published: August 2022

AbstractClinical trials for Alzheimer's disease (AD) are slower to enroll study participants, take longer to complete, and are more expensive than trials in most other therapeutic areas. The recruitment and retention of a large number of qualified, diverse volunteers to participate in clinical research studies remain among the key barriers to the successful completion of AD clinical trials. An advisory panel of experts from academia, patient‐advocacy organizations, philanthropy, non‐profit, government, and industry convened in 2020 to assess the critical challenges facing recruitment in Alzheimer's clinical trials and develop a set of recommendations to overcome them. This paper briefly reviews existing challenges in AD clinical research and discusses the feasibility and implications of the panel's recommendations for actionable and inclusive solutions to accelerate the development of novel therapies for AD.