bluuebunny/crossref_metadata_2025_split huggingface dataset:
Displaced searches for light vector bosons at Belle II
Authors: Bandyopadhyay Triparno , Chakraborty Sabyasachi , Trifinopoulos Sokratis 
Published: May 2022

Abstract
With a design luminosity of 50 ab−1 and detectors with tracking capabilities extending beyond 1 m, the Belle II experiment is the perfect laboratory for the search of particles that couple weakly to the Standard Model and have a characteristic decay length of a few centimetres and more. We show that for models of dark photons and other light vector bosons, Belle II will be successful in probing regions of parameter space which are as of now unexplored by any experiment. In addition, for models where the vector boson couples sub-dominantly to the electron and quarks as compared to muons, e.g. in the Lμ−Lτ model, Belle II will probe regions of mass and couplings compatible with the anomalous magnetic moment of muon. We discuss these results and derive the projected sensitivity of Belle II for a handful of other models. Finally, even with the currently accumulated data, ∼ 200 fb−1, Belle II should be able to cover regions of parameter space pertaining to the X(17) boson postulated to solve the ATOMKI anomaly.
The Cremona problem in dimension 2
Authors: Bartenwerfer Wolfgang 
Published: May 2022

AbstractThe Cremona conjecture, also called Jacobi problem, claims that a polynomial morphism $${{\mathbb C}^n \longrightarrow {\mathbb C}^n}$$

C

n

⟶

C

n

is invertible as a polynomial morphism if its Jacobian is constant and not zero. In this paper, we show that the conjecture is true for $$n = 2$$

n
=
2

. The starting point of our proof is an important result of Shreeram Abhyankar. Then we use a computation in rigid geometry to achieve the result.
Role of LL-37 in thrombotic complications in patients with COVID-19
Authors: Duan Zilei , Zhang Juan , Chen Xue , Liu Ming , Zhao Hongwen , Jin Lin , Zhang Zhiye , Luan Ning , Meng Ping , Wang Jing , Tan Zhaoxia , Li Yaxiong , Deng Guohong , Lai Ren 
Published: May 2022

AbstractBlood clot formation induced by dysfunctional coagulation is a frequent complication of coronavirus disease 2019 (COVID-19) and a high-risk factor for severe illness and death. Neutrophil extracellular traps (NETs) are implicated in COVID-19-induced immunothrombosis. Furthermore, human cathelicidin, a NET component, can perturb the interaction between the SARS-CoV-2 spike protein and its ACE2 receptor, which mediates viral entry into cells. At present, however, the levels of cathelicidin antimicrobial peptides after SARS-CoV-2 infection and their role in COVID-19 thrombosis formation remain unclear. In the current study, we analyzed coagulation function and found a decrease in thrombin time but an increase in fibrinogen level, prothrombin time, and activated partial thromboplastin time in COVID-19 patients. In addition, the cathelicidin antimicrobial peptide LL-37 was upregulated by the spike protein and significantly elevated in the plasma of patients. Furthermore, LL-37 levels were negatively correlated with thrombin time but positively correlated with fibrinogen level. In addition to platelet activation, cathelicidin peptides enhanced the activity of coagulation factors, such as factor Xa (FXa) and thrombin, which may induce hypercoagulation in diseases with high cathelicidin peptide levels. Injection of cathelicidin peptides promoted the formation of thrombosis, whereas deletion of cathelicidin inhibited thrombosis in vivo. These results suggest that cathelicidin antimicrobial peptide LL-37 is elevated during SARS-CoV-2 infection, which may induce hypercoagulation in COVID-19 patients by activating coagulation factors.
On a Conjecture by Hundertmark and Simon
Authors: Laptev Ari , Loss Michael , Schimmer Lukas 
Published: May 2022

AbstractThe main result of this paper is a complete proof of a new Lieb–Thirring-type inequality for Jacobi matrices originally conjectured by Hundertmark and Simon. In particular, it is proved that the estimate on the sum of eigenvalues does not depend on the off-diagonal terms as long as they are smaller than their asymptotic value. An interesting feature of the proof is that it employs a technique originally used by Hundertmark–Laptev–Weidl concerning sums of singular values for compact operators. This technique seems to be novel in the context of Jacobi matrices.
WGNAM: whole-genome nested association mapping
Authors: Paccapelo M. Valeria , Kelly Alison M. , Christopher Jack T. , Verbyla Arūnas P. 
Published: May 2022

AbstractKey messageA powerful QTL analysis method for nested association mapping populations is presented. Based on a one-stage multi-locus model, it provides accurate predictions of founder specific QTL effects.AbstractNested association mapping (NAM) populations have been created to enable the identification of quantitative trait loci (QTL) in different genetic backgrounds. A whole-genome nested association mapping (WGNAM) method is presented to perform QTL analysis in NAM populations. The WGNAM method is an adaptation of the multi-parent whole genome average interval mapping approach where the crossing design is incorporated through the probability of inheriting founder alleles for every marker across the genome. Based on a linear mixed model, this method provides a one-stage analysis of raw phenotypic data, molecular markers, and crossing design. It simultaneously scans the whole-genome through an iterative process leading to a model with all the identified QTL while keeping the false positive rate low. The WGNAM approach was assessed through a simulation study, confirming to be a powerful and accurate method for QTL analysis for a NAM population. This novel method can also accommodate a multi-reference NAM (MR-NAM) population where donor parents are crossed with multiple reference parents to increase genetic diversity. Therefore, a demonstration is presented using a MR-NAM population for wheat (Triticum aestivumL.) to perform a QTL analysis for plant height. The strength and size of the putative QTL were summarized enhancing the understanding of the QTL effects depending on the parental origin. Compared to other methods, the proposed methodology based on a one-stage analysis provides greater power to detect QTL and increased accuracy in the estimation of their effects. The WGNAM method establishes the basis for accurate QTL mapping studies for NAM and MR-NAM populations.
Disruption of Genes Encoding Putative Zwitterionic Capsular Polysaccharides of Diverse Intestinal Bacteroides Reduces the Induction of Host Anti-Inflammatory Factors
Authors: Arnolds Kathleen L. , Yamada Eiko , Neff C. Preston , Schneider Jennifer M. , Palmer Brent E. , Lozupone Catherine A. 
Published: May 2022

Abstract
Bacterial zwitterionic capsular polysaccharides (ZPS), such as polysaccharide A (PSA) of the intestinal commensal Bacteroides fragilis, have been shown to modulate T cells, including inducing anti-inflammatory IL-10-secreting T regulatory cells (Tregs). We previously used a genomic screen to identify diverse host-associated bacteria with the predicted genetic capacity to produce ZPSs related to PSA of B. fragilis and hypothesized that genetic disruption (KO) of a key functional gene within these operons would reduce the anti-inflammatory activity of these bacteria. We found that ZPS-KO bacteria in two common gut commensals, Bacteroides uniformis and Bacteroides cellulosilyticus, had a reduced ability to induce Tregs and IL-10 in stimulations of human peripheral blood mononuclear cells (PBMCs). Additionally, we found that macrophage stimulated with either wildtype B. fragilis or B. uniformis produced significantly more IL-10 than KOs, indicating a potentially novel function of ZPS of shifting the cytokine response in macrophages to a more anti-inflammatory state. These findings support the hypothesis that these related ZPS may represent a shared strategy to modulate host immune responses.
Preliminary results of abdominal simultaneous multi-slice accelerated diffusion-weighted imaging with motion-correction in patients with cystic fibrosis and impaired compliance
Authors: Glutig Katja , Krüger Paul-Christian , Oberreuther Theresa , Nickel Marcel Dominik , Teichgräber Ulf , Lorenz Michael , Mentzel Hans-Joachim , Krämer Martin 
Published: May 2022

Abstract
Objectives

The aim of this prospective study was to compare scan time, image quality, signal-to-noise Ratio (SNR), and apparent diffusion coefficient (ADC) values of simultaneous multi-slice accelerated diffusion-weighted imaging with motion-correction (DWI SMS Moco) to standard diffusion-weighted imaging (sDWI) in free-breathing abdominal magnetic resonance imaging (MRI) in pediatric and young adult patients with cystic fibrosis (CF).

Material and methods
16 patients (7 male and 9 female, 12–41 years old) with CF were examined prospectively in a single-center from November 2020 to March 2021 on a 1.5 Tesla clinical MR scanner. The characteristics of overall image quality and delimitability of mesenteric lymph nodes were evaluated using a 5-point Likert scale by two experienced pediatric radiologists independently from each other. Quantitative parameters with SNR and ADC values were assessed in 8 different locations and compared using a Wilcoxon signed-rank test.

Results
The acquisition time for DWI SMS Moco was 32% shorter than for sDWI. Regarding quality comparison, overall image quality and delimitability of mesenteric lymph nodes were significant higher in DWI SMS Moco (p ≤ 0.05 for both readers). The readers preferred DWI SMS Moco to sDWI in all cases (16/16). Mean SNR values from DWI SMS Moco and sDWI were similar in 7 from 8 locations. The ADC values showed no significant difference between DWI SMS Moco and sDWI in any of the evaluated locations (p > 0.05).

Conclusions
The DWI SMS Moco improves overall image quality and delimitability of mesenteric lymph nodes compared to sDWI with similar SNR and ADC values and a distinguished reduction of scan time in free-breathing by one third. We conclude that MRI with DWI SMS Moco could be helpful in monitoring the effect of the high-efficiency modulator (HEM) therapy in cystic fibrosis (CF) patients homozygous or heterozygous for F508del in the abdomen.
Laparoscopic Heller Myotomy and Dor Fundoplication
Authors: McCarthy Elizabeth , Jao Susan Laura , Pryor Aurora D. 
Published: May 2022

AbstractIntroductionAchalasia is an esophageal motility disorder characterized by disordered esophageal peristalsis with failed relaxation of the lower esophageal sphincter resulting in a functional obstruction.Treatment can include medical, endoscopic, or surgical interventions. Although none of these are curative, they each offer methods to create esophageal outflow.Materials and MethodsThis article discusses our preferred surgical technique used for laparoscopic Heller myotomy with Dor fundoplication. This technique has been developed over the author's career.ConclusionThe technique discussed provides a safe and effective strategy to manage achalasia.
Improving the spatiotemporal resolution of remotely sensed ET information for water management through Landsat, Sentinel-2, ECOSTRESS and VIIRS data fusion
Authors: Xue Jie , Anderson Martha C. , Gao Feng , Hain Christopher , Knipper Kyle R. , Yang Yun , Kustas William P. , Yang Yang , Bambach Nicolas , McElrone Andrew J. , Castro Sebastian J. , Alfieri Joseph G. , Prueger John H. , McKee Lynn G. , Hipps Lawrence E. , del Mar Alsina María 
Published: May 2022

AbstractRobust information on consumptive water use (evapotranspiration, ET) derived from remote sensing can significantly benefit water decision-making in agriculture, informing irrigation schedules and water management plans over extended regions. To be of optimal utility for operational usage, these remote sensing ET data should be generated at the sub-field spatial resolution and daily-to-weekly timesteps commensurate with the scales of water management activities. However, current methods for field-scale ET retrieval based on thermal infrared (TIR) imaging, a valuable diagnostic of canopy stress and surface moisture status, are limited by the temporal revisit of available medium-resolution (100 m or finer) thermal satellite sensors. This study investigates the efficacy of a data fusion method for combining information from multiple medium-resolution sensors toward generating high spatiotemporal resolution ET products for water management. TIR data from Landsat and ECOSTRESS (both at ~ 100-m native resolution), and VIIRS (375-m native) are sharpened to a common 30-m grid using surface reflectance data from the Harmonized Landsat-Sentinel dataset. Periodic 30-m ET retrievals from these combined thermal data sources are fused with daily retrievals from unsharpened VIIRS to generate daily, 30-m ET image timeseries. The accuracy of this mapping method is tested over several irrigated cropping systems in the Central Valley of California in comparison with flux tower observations, including measurements over irrigated vineyards collected in the GRAPEX campaign. Results demonstrate the operational value added by the augmented TIR sensor suite compared to Landsat alone, in terms of capturing daily ET variability and reduced latency for real-time applications. The method also provides means for incorporating new sources of imaging from future planned thermal missions, further improving our ability to map rapid changes in crop water use at field scales.
Decadal stability of coral reef benthic communities on Palmyra Atoll, central Pacific, through two bleaching events
Authors: Khen Adi , Johnson Maggie D. , Fox Michael D. , Clements Samantha M. , Carter Amanda L. , Smith Jennifer E. 
Published: May 2022

AbstractThe prevalence of coral bleaching due to thermal stress has been increasing on coral reefs worldwide. While many studies have documented how corals respond to warming, fewer have focused on benthic community responses over longer time periods or on the response of non-coral taxa (e.g., crustose coralline algae, macroalgae, or turf). Here, we quantify spatial and temporal changes in benthic community composition over a decade using image analysis of permanent photoquadrats on Palmyra Atoll in the central Pacific Ocean. Eighty permanent plots were photographed annually between 2009 and 2018 on both the wave-exposed fore reef (FR, 10 m depth,n = 4 sites) and the wave-sheltered reef terrace (RT, 5 m depth,n = 4 sites) habitats. The El Niño events of 2009–2010 and 2015–2016 resulted in acute thermal stress and coral bleaching was observed at both reef habitats during these events. Across 10 yr and two bleaching events, the benthic community structure on Palmyra shows evidence of long-term stability. Communities on the RT exhibited minimal change in percent cover of the dominant functional groups, while the FR had greater variability and minor declines in hard coral cover. There was also spatial variation in the trajectory of each site through time. Coral cover decreased at some sites 1 yr following both bleaching events and was replaced by different algal groups depending on the site, yet returned to pre-bleaching levels within 2 yr. Overall, our data reveal the resilience of calcifier-dominated coral reef communities on Palmyra Atoll that have persisted over the last decade despite two bleaching events, demonstrating the capacity for these reefs to recover from and/or withstand disturbances in the absence of local stressors.
Combination of docetaxel versus nonsteroidal antiandrogen with androgen deprivation therapy for high-volume metastatic hormone-sensitive prostate cancer: a propensity score-matched analysis
Authors: Yanagisawa Takafumi , Kimura Takahiro , Hata Kenichi , Narita Shintaro , Hatakeyama Shingo , Mori Keiichiro , Sano Takayuki , Otsuka Takashi , Iwamoto Yuya , Enei Yuki , Nakazono Minoru , Sakanaka Keigo , Iwatani Kosuke , Matsukawa Akihiro , Atsuta Mahito , Nishikawa Hideomi , Tsuzuki Shunsuke , Miki Jun , Habuchi Tomonori , Ohyama Chikara , Shariat Shahrokh F. , Egawa Shin 
Published: May 2022

Abstract
Purpose
The aim of this study was to investigate the oncologic efficacy of combining docetaxel with androgen deprivation therapy (ADT) versus nonsteroidal antiandrogen (NSAA) with ADT in patients with high-volume metastatic hormone-sensitive prostate cancer (mHSPC) with focus on the effect of sequential therapy in a real-world clinical practice setting.

Methods
The records of 382 patients who harbored high-volume mHSPC, based on the CHAARTED criteria, and had received ADT with either docetaxel (n = 92) or NSAA (bicalutamide) (n = 290) were retrospectively analyzed. The cohorts were matched by one-to-one propensity scores based on patient demographics. Overall survival (OS), cancer-specific survival (CSS), progression-free survival (PFS), including time to castration-resistant prostate cancer (CRPC), and time to second-line progression (PFS2) were compared. 2nd-line PFS defined as the time from CRPC diagnosis to progression after second-line therapy was also compared.

Results
After matching, a total of 170 patients were retained: 85 patients treated with docetaxel + ADT and 85 patients treated with NSAA + ADT. The median OS and CSS for docetaxel + ADT versus NSAA + ADT were not reached (NR) vs. 49 months (p = 0.02) and NR vs. 55 months (p = 0.02), respectively. Median time to CRPC and PFS2 in patients treated with docetaxel + ADT was significantly longer compared to those treated with NSAA (22 vs. 12 months; p = 0.003 and, NR vs. 28 months; p < 0.001, respectively). There was no significant difference in 2nd-line PFS between the two groups.

Conclusions
Our analysis suggested that ADT with docetaxel significantly prolonged OS and CSS owing to a better time to CRPC and PFS2 in comparison to NSAA + ADT in high-volume mHSPC.
Archimetrosis: the evolution of a disease and its extant presentation
Authors: Leyendecker Gerhard , Wildt Ludwig , Laschke Matthias W. , Mall Gerhard 
Published: May 2022

Abstract
Purpose
This article presents a novel concept of the evolution and, thus, the pathogenesis of uterine adenomyosis as well as peritoneal and peripheral endometriosis. Presently, no unifying denomination of this nosological entity exists.

Methods
An extensive search of the literature on primate evolution was performed. This included comparative functional morphology with special focus on the evolution of the birthing process that fundamentally differs between the haplorrhine primates and most of the other eutherian mammals. The data were correlated with the results of own research on the pathophysiology of human archimetrosis and with the extant presentation of the disease.

Results
The term Archimetrosis is suggested as a denomination of the nosological entity. Archimetrosis occurs in human females and also in subhuman primates. There are common features in the reproductive process of haplorrhine primates such as spontaneous ovulation and corpus luteum formation, spontaneous decidualization and menstruation. These have fused Müllerian ducts resulting in a uterus simplex. Following a usually singleton pregnancy, the fetus is delivered in the skull position. Some of these features are shared by other mammals, but not in that simultaneous fashion. In haplorrhine primates, with the stratum vasculare, a new myometrial layer has evolved during the time of the Cretaceous–Terrestrial Revolution (KTR) that subserves expulsion of the conceptus and externalization of menstrual debris in non-conceptive cycles. Hypercontractility of this layer has evolved as an advantage with respect to the survival of the mother and the birth of a living child during delivery and may be experienced as primary dysmenorrhea during menstruation. It may result in tissue injury by the sheer power of the contractions and possibly by the associated uterine ischemia. Moreover, the lesions at extra-uterine sites appear to be maintained by biomechanical stress.

Conclusions
Since the pathogenesis of archimetrosis is connected with the evolution of the stratum vasculare, tissue injury and repair (TIAR) turns out to be the most parsimonious explanation for the development of the disease based on clinical, experimental and evolutionary evidence. Furthermore, a careful analysis of the published clinical data suggests that, in the risk population with uterine hypercontractility, the disease develops with a yet to be defined latency phase after the onset of the biomechanical injury. This opens a new avenue of prevention of the disease in potentially affected women that we consider to be primarily highly fertile.
Complications and satisfaction in transwomen receiving breast augmentation: short- and long-term outcomes
Authors: Schoffer A. K. , Bittner A. K. , Hess J. , Kimmig R. , Hoffmann O. 
Published: May 2022

Abstract
Background
To achieve long-term improvement in health care of transgender women, it is necessary to analyze all aspects of gender-confirming surgery, especially the relation of risks and benefits occurring in these procedures. While there are many studies presenting data on the urologic part of the surgery, there are just few data about complications and satisfaction with breast augmentation.

Methods
This is a retrospective study using parts of the BREAST-Q Augmentation Questionnaire and additional questions for symptoms of capsular contracture and re-operations and analyzing archived patient records of all transwomen which were operated at University Hospital Essen from 2007 to 2020.

Results
99 of these 159 patients (62%) completed the questionnaire after a median time of 4 years after surgery. Breast augmentation led to re-operations due to complications in 5%. The rate of capsular contracture (Baker Grad III–IV) in this population was 3%. Most patients (75%) rated high scores of satisfaction with outcome (more than 70 points) and denied to have restrictions due to their implants in their everyday life. All patients reported an improvement in their quality of life owing to breast augmentation.

Conclusion
Breast augmentation by inserting silicon implants is a safe surgical procedure which takes an important part in reducing gender dysphoria.
Neurological update: hereditary neuropathies
Authors: Kramarz Caroline , Rossor Alexander M. 
Published: May 2022

AbstractIn this update, we review the recent discovery of autosomal recessive variants in sorbitol dehydrogenase as one of the commonest and potentially treatable causes of hereditary motor neuropathy and CMT2. We also report on recent therapeutic advances in hereditary neuropathy including the use of lipid nanoparticle sequestered antisense oligonucleotides in CMT1A and lipid nanoparticle delivered CRISPR-Cas9 gene editing in ATTR amyloidosis.
Continuum multiscale modeling of absorption processes in micro- and nanocatalysts
Authors: Köhler Maximilian , Junker Philipp , Balzani Daniel 
Published: May 2022

AbstractIn this paper, we propose a novel, semi-analytic approach for the two-scale, computational modeling of concentration transport in packed bed reactors. Within the reactor, catalytic pellets are stacked, which alter the concentration evolution. Firstly, the considered experimental setup is discussed and a naive one-scale approach is presented. This one-scale model motivates, due to unphysical fitted values, to enrich the computational procedure by another scale. The computations on the second scale, here referred to as microscale, are based on a proper investigation of the diffusion process in the catalytic pellets from which, after continuum-consistent considerations, a sink term for the macroscopic advection–diffusion–reaction process can be identified. For the special case of a spherical catalyst pellet, the parabolic partial differential equation at the microscale can be reduced to a single ordinary differential equation in time through a semi-analytic approach. After the presentation of our model, we show results for its calibration against the macroscopic response of a simple standard mass transport experiment. Based thereon, the effective diffusion parameters of the catalyst pellets can be identified.