bluuebunny/crossref_metadata_2025_split huggingface dataset:
An extremely rare case of calcinosis cutis in human Cushing’s disease
Authors: Rbiai Najoua , Mahroug Ikram , Zizi Nada , Latrech Hanane 
Published: June 2022

Summary
Cushing’s disease or pituitary adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome is considered a rare condition. It is caused by hypersecretion of the ACTH by a pituitary adenoma that ultimately induces endogenous hypercortisolism by stimulating the adrenal glands. It is responsible for significant morbidity and mortality. The clinical signs and symptoms of hypercortisolism are usually common and non-specific including obesity, moon face, hypertension, hirsutism and facial plethora. The association between Cushing’s disease and calcinosis cutis which is defined as dystrophic calcium deposition in the skin and subcutaneous tissues is extremely rare. To the best of our knowledge, it has never been described previously in humans, probably like a symptom or complication of chronic and severe hypercortisolism. In this paper, we report a case of a 30-year-old female diagnosed with Cushing’s disease and presented bilateral leg’s calcinosis cutis complicated with ulceration. The evolution was favorable and the complete cicatrization was obtained 12 months following the suppression of systemic glucocorticoid excess.

Learning points

Calcinosis cutis is common in autoimmune connective diseases. However, to our knowledge, it has never been reported in humans with Cushing’s disease.

Given the rarity of this association, the diagnostic approach to calcinosis cutis must exclude the other etiologies.

Calcinosis cutis is challenging to treat with no gold standard therapy. In our case, the use of the combination of colchicine and bisphosphonates does not significantly improve the patient’s outcomes. In fact, we suppose that without treating the endogenous hypercortisolism, the calcinosis cutis will not resolve.
The landscape of retesting in childhood-onset idiopathic growth hormone deficiency and its reversibility: a systematic review and meta-analysis
Authors: Laurer Elisabeth , Sirovina Antonio , Blaschitz Alexandra , Tischlinger Katharina , Montero-Lopez Rodrigo , Hörtenhuber Thomas , Wimleitner Marlene , Högler Wolfgang 
Published: June 2022

Abstract

Objective
Children diagnosed with idiopathic isolated growth hormone deficiency (IGHD) are frequently observed to no longer be GH-deficient at a later stage of growth as a result of ‘GHD reversal’. Reevaluation of GH status by stimulation test is currently incorporated into management guidelines at attainment of final height (FH). Over the past three decades, numerous studies have evaluated reversal rates using different methodologies including crucial parameters like GHD aetiology, GH cut-off and retesting time point, with heterogeneous results.
We aimed to systematically analyse the reversibility of childhood-onset IGHD dependent on retesting GH cut-offs and retesting time points.

Methods
PubMed, Cochrane Library, TRIP database and NHS Evidence were searched for publications investigating the reversibility of IGHD from database initiation to 30 June 2020 following PRISMA recommendations. Study cohorts were pooled according to retesting GH cut-off and time point. Reversal rates were calculated using random-effects models.

Results
Of the 29 studies initially identified, 25 provided sufficient detail for IGHD analysis, resulting in 2030 IGHD patient data. Reversal rates decreased significantly as the retesting GH cut-off increased (P  = 0.0013). Pooled (95% CI) reversal rates were 80% (59–92%, n  = 227), 73% (62–81%, n  = 516) and 55% (41–68%, n  = 1287) for cohorts using retesting GH cut-offs of 3–4 ng/mL, 5–6 ng/mL and 7.7–10 ng/mL, respectively. Individuals retested at FH (n  = 674) showed a pooled reversal rate of 74% (64–82%) compared to 48% (25–71%) when retested before FH (n  = 653).

Conclusion
Provided evidence supports reevaluation of current IGHD management guidelines. The high reversal rates should instigate consideration of early retesting.
Mechanisms of group B Streptococcus-mediated preterm birth: lessons learnt from animal models
Authors: Kurian Noble K , Modi Deepak 
Published: June 2022

Graphical abstract

Abstract
Group B Streptococcus (GBS) is an opportunistic pathogenic bacterium which upon colonization in the female reproductive tract can cause preterm births, fetal injury, and demise. Several determinants for GBS pathogenesis have been explored so far through the studies using animal models ranging from mice to non-human primates. The results from these experimental data have identified outer membrane vesicles, β-hemolysin, hyaluronidase, and Cas9 of GBS as major virulence factors leading to preterm births. Most of these factors drive inflammation through activation of NLRP3 and elevated production of IL1-β. However, the absence of one of the factors from the pathogen reduces but does not completely abolish the pathogenesis of GBS suggesting the involvement of more than one factor in causing preterm birth. This makes further exploration of other virulence factors of GBS pathogenesis important in gaining an insight into the mechanistic basis of GBS-mediated preterm births.

Lay summary
Group B Streptococcus (GBS) is a pathogenic bacteria whose infection in the reproductive tract during pregnancy can cause premature delivery. This bacterial infection is one of the major causes of death of mother and baby during pregnancy, and the bacteria is prevalent in all parts of the world. This makes the research on GBS so important and many of the mechanisms behind GBS infection during pregnancy still remain unexplored. In this review, we have outlined how various animal models contributed in finding the mechanism of GBS pathogenesis. The review also focuses on compiling various virulence factors which makes GBS pathogenic in the vulnerable. Understanding the mechanisms of infection by GBS will be crucial in developing drugs and vaccines to protect against the harmful effects of the bacteria.
New Vector of Development of Modern Ukrainian Dialectology
Authors: Beley Oleg 
Published: June 2022

Review “Hutsul dialect vocabulary and phrasemics in the Ukrainian literary language“. Dictionary : In 2 volumes / Editor-in-Chief :Vasyl Hreshchuk. Ivano-Frankivsk: Misto NV, 1, 2019, 584 p.
Hutsul dialect vocabulary and phrasemics in the Ukrainian literary language. Dictionary : In 2 volumes / Editor-in-Chief: Vasyl Hreshchuk. Ivano-Frankivsk: Misto NV, 2, 2020, 468 p.
«The November Breakdown» («November Action») 1918: a Revolution or a Military Coup?
Authors: Monolatii Ivan 
Published: June 2022

The purpose of the study is to analyze peculiarities of the historical event «The November Breakdown» («November Action») – the national democratic revolution in the Western Ukrainian lands – not as a revolution in its classical version, but a military coup with the elements of the national liberation struggle of Western Ukrainians in the autumn of 1918. On the basis of the historical and political analysis of the historiographical heritage concerning the preconditions and creation of the Western Ukrainian People’s Republic, the events of October 31 – November 1, 1918, are described as discrepancies and generalizations of their direct participants; the research also clarifies the factors of political and ideological «explanations» of the revolutionary «November Breakdown» in historiography of the Ukrainian diaspora of the 20th Century. The Soviet and contemporary Ukrainian historiography statements about the «revolutionary nature» of the events in Eastern Halychyna in 1918, and hence the November 1918 national democratic revolution, are still debatable. Halychyna Ukrainians made a legal proclaimation of the Ukrainian state within the framework of the Austrian-Hungarian state, they were waiting for a peaceful transfer of power in Eastern Halychyna, and the armed uprising of October 31 – November 1, 1918, became a military coup in the geopolitical realities of the rising tension in the Polish-Ukrainian relations. Therefore, on November 1, the Austro-Hungarian government authorized an act of transfer of the state power in Eastern Halychyna to the Ukrainian National Council, and on November 13, 1918, the Council proclaimed Western Ukrainian People’s Republic. The origins of the myth about the «revolutionary character», or «revolution» in Eastern Halychyna in 1918, are rooted in attempts to «inject» the non-existent in reality class struggle of the region population into the broader context of the Bolshevik and socialist revolution. During the Khrushchev Thaw, in 1957 this myth underwent certain modification in the famous article of historian O.Karpenko, and later on, in 1993, this myth transformation turned into a «national-democratic revolution» in Western Ukrainian lands. In fact, the memoirs of the participants and creators of the «November Action», the external sources, as well as the mass media of that, do not interpret the events under study just as “a revolution”, but only as “a coup”, “disarmament”, etc., which testifies to the militaristic nature of events.
Author and Style: Intellectualization of Victor Domontovych`s Artistic Discourse
Authors: Kononenko Vitaly 
Published: June 2022

The article highlights the features of the idiostyle of Victor Domontovych, a writer of 1920s, a representative of modernist artistic discourse. The stylistic manner of the author's writing shows his intellectualism, principles of his extraordinary scientifically oriented linguistic thinking. V. Domontovych depicts artistic reality through the prism of the ontological clash of categories of rational and irrational, real and unreal, intellectual and primitive-bourgeois, sexual and asexual. Using the concepts of plausible and implausible, real and conditional, the author characterizes the psycho-behavioral stereotypes of his characters in order to comment and evaluate their actions and decisions; he often uses a descriptive and contemplative manner, and forms of logical conclusions; therefore, a symbiosis of scientific and fictional presentation is formed.
Domontovych's texts are full of ironic and mocking intonations in order to expose spirituality, low culture, meanness; the author strongly condemns selfishness, callousness, dishonesty in the behavior of the characters; the sharpness of his critical vision is directed against the arrogance of the intelligentsia, unjustified rationalism, scientific-like thinking, and bourgeoisie. The intellectual novels of the writer can be considered as extended metaphorical constructions, integral figurative and symbolic structures, profound artistic worldview carriers, as well as systems of meaning mythologizing. The author’s usage of linguistic and stylistic means is not extensive; they are unusual in their associative-figurative aspect and intended for the domain of cognitively meaningful perception. The expressiveness of texts is achieved through an implicit coded word usage, there is space for the reader to think creatively as the texts rely on the conceptual interaction within the system Author-Text-Reader.
Dramaturgy of Lesia Ukrainka and European Modern Drama: Text, Context
Authors: Khorob Stepan 
Published: June 2022

It is difficult, if not impossible, to find in world literature an artistic phenomenon similar to the work of Lesya Ukrainka. For as long as a century scientists have been trying their best to highlight and explain this versatile astonishing national phenomenon: the phenomenon of the artist, human, woman. It is definitely not accidental that, avoiding analogies, Ivan Franko called Lesya Ukrainka nearly the only man "all across the whole of modern Ukraine" for her spirit strength and true Prometheus obsession, while Mykhailo Hrushevsky named her the "Ukrainian Shakespeare". According to Mykola Zerov, these similarities are clearly pronounced not in poetry (social lyrics, intimate lyrics), but primarily in her drama, which, in fact, makes up a unique modern world of ideas and images not only for national but also for the Western European literature.
Occasional Word Formation in the Expressiveness of a Text
Authors: Hreshchuk Vasyl 
Published: June 2022

The article analyzes the contribution of occasional word formation to the expressiveness of the text. Making the text more expressive by means of an occasional word-formation takes place when the process of text creation involves a coining of a new word which violates the norms of lexical derivation in its structural and semantic parameters. Due to its optional, new, non-normative, functional one-time nature, occasional derivatives (coinages) have become one of the major linguistic means of forming the connotative component of the semantics of the text or its segment. An occasionally derived word appears as a result of a combination of common word-forming components, characteristic for a particular linguistic system, i.e. a creative basis and a derivational formant, but their interaction in a particular derivative may result in the expansion of internal valence and pushes it beyond the language norm. The article focuses on a detailed description of the non-normative interaction of common creative bases and forms within the main parts of speech and word formation methods as well as their role in the expressiveness of the text. The article also describes less common ways of forming the linguistic expression of the text by means of occasional coinages. The latter methods include the use of word-forming formats stylized according to the derivational means of another language present in the text, permutation of formative bases which are the components of a word-forming structure, the amalgamation of several prefixes, which either strengthen the meaning of the first one or neutralize the value of the following prefix. Emotionally colored occasional derivatives (coinages) constitute an important component of text creation as they are responsible for the pragmatic sphere of the text which is connected with the subjective modality of the text and its realization.
Narrative Strategy of Paul Verlaine’s Prose Poems
Authors: Bigun Olga 
Published: June 2022

The article analyses historical and genetic origins of the genre of prose poem. It singles out the genus-genre syncretism of prose poem, the foundation of which lies in the intertwining and interpenetration of epic, dramatic and lyrical principles, "overlapping" of different modifications. The material under study is represented by a collection of prose poems by Paul Verlaine Les mémoires d'un veuf. The aim of the article is to study the narrative peculiarities of a prose poem given the syncretic nature of the genre, and its delivery, which allows to analyze artistic works from the standpoint of their composition and structure. According to the internal genre-style dominant, three forms of narrative modeling are distinguished: a narrative with the predominance of epic-realistic elements, a narrative with the predominance of lyrical-impressionistic elements and dramatization of the narrative. According to its plot-compositional structure works of the epic-realistic block can be divided into two categories: the first one is determined by the dominance of the linear principle of the beginning, the second one is characterized by the fragmentary principle of composition with the increased aestheticization and intellectualization, in-depth psychological insights, and appeal to “eternal themes”. The works of the lyrical-impressionist model include an internal psychologized plot, attention to feelings and changes in emotional states, as well as stylistic syncretism. The lyrical semantics of the work is closely connected with the position of the lyrical character, personal author's experience. The entire plot of the poem is centered on the inner world of the poetic lyrical character; therefore, it is not the work itself that conveys the plot line but the character’s emotional experiences do that. It is the ability to express a particular feeling, a state without adhering to the plot line that becomes decisive for the dramatized type of story.
Factors Associated With Severe Illness in Patients Aged &lt;21 Years Hospitalized for COVID-19
Authors: Choudhary Rewa , Webber Bryant J. , Womack Lindsay S. , Dupont Hannah K. , Chiu Sophia K. , Wanga Valentine , Gerdes Megan E. , Hsu Sophia , Shi Dallas S. , Dulski Theresa M. , Idubor Osatohamwen I. , Wendel Arthur M. , Agathis Nickolas T. , Anderson Kristi , Boyles Tricia , Click Eleanor S. , Da Silva Juliana , Evans Mary E. , Gold Jeremy A.W. , Haston Julia C. , Logan Pamela , Maloney Susan A. , Martinez Marisol , Natarajan Pavithra , Spicer Kevin B. , Swancutt Mark , Stevens Valerie A. , Rogers-Brown Jessica , Chandra Gyan , Light Megan , Barr Frederick E. , Snowden Jessica , Kociolek Larry K. , McHugh Matthew , Wessel David L. , Simpson Joelle N. , Gorman Kathleen C. , Breslin Kristen A. , DeBiasi Roberta L. , Thompson Aaron , Kline Mark W. , Boom Julie A. , Singh Ila R. , Dowlin Michael , Wietecha Mark , Schweitzer Beth , Morris Sapna Bamrah , Koumans Emilia H. , Ko Jean Y. , Siegel David A. , Kimball Anne A. 
Published: June 2022

OBJECTIVES
To describe coronavirus disease 2019 (COVID-19)–related pediatric hospitalizations during a period of B.1.617.2 (Δ) variant predominance and to determine age-specific factors associated with severe illness.

METHODS
We abstracted data from medical charts to conduct a cross-sectional study of patients aged &lt;21 years hospitalized at 6 United States children’s hospitals from July to August 2021 for COVID-19 or with an incidental positive severe acute respiratory syndrome coronavirus 2 test. Among patients with COVID-19, we assessed factors associated with severe illness by calculating age-stratified prevalence ratios (PR). We defined severe illness as receiving high-flow nasal cannula, positive airway pressure, or invasive mechanical ventilation.

RESULTS
Of 947 hospitalized patients, 759 (80.1%) had COVID-19, of whom 287 (37.8%) had severe illness. Factors associated with severe illness included coinfection with respiratory syncytial virus (RSV) (PR 3.64) and bacteria (PR 1.88) in infants; RSV coinfection in patients aged 1 to 4 years (PR 1.96); and obesity in patients aged 5 to 11 (PR 2.20) and 12 to 17 years (PR 2.48). Having ≥2 underlying medical conditions was associated with severe illness in patients aged &lt;1 (PR 1.82), 5 to 11 (PR 3.72), and 12 to 17 years (PR 3.19).

CONCLUSIONS
Among patients hospitalized for COVID-19, factors associated with severe illness included RSV coinfection in those aged &lt;5 years, obesity in those aged 5 to 17 years, and other underlying conditions for all age groups &lt;18 years. These findings can inform pediatric practice, risk communication, and prevention strategies, including vaccination against COVID-19.
Creating spaces for engagement in meaningful activities
Authors: Maslo Elina 
Published: June 2022

AbstractAdults learn when they actively engage in meaningful activities. Meaningfulness is an extremely subjective factor, which depends on experiences, values, attitudes and much more. “The ways in which adults learn in and through the workplace are rooted in educational trajectories and their complex intertwining with social institutions (of labour market, workplace, community) and social roles (of employee, citizen, family member) at different stages of the life-course” (Kersh et al., 2011, 355). The interplay between work, studies and lifeworld is the focus of this study, conducted at the University College Copenhagen in 2020–2021. At the College, and in teacher training in particular, we are asking two important questions these days: How can we establish an engaging learning culture in our educational program? How can we create space for all students to find the relevant content to engage with? How can this be done when our students are so diverse according to age, life and work experiences, life situation and life interests? In this article, I analyse my own workplace learning and professional development during my first 2 years at University College, where I have been working on transforming my experience from the university to a new context – a professional teacher education program at University College.
CFD modeling of petcoke co-combustion in a real cement kiln: The effect of the turbulence-chemistry interaction model applied with K-ϵ variations
Authors: Ngadi Z. , Lahlaouti M.L. 
Published: June 2022

Abstract
Using alternative fuels (AF) in industry high consuming energy where fossil fuels are largely consumed may be a great solution to decrease CO2 emission and cost production. Or, when using these alternative fuels, the combustion may be difficult to control regarding the different components of AFs compared to fossil fuels. In this case, the use of the computational fluid dynamics CFD tools is a great solution to predict the AFs combustion behavior. This paper represents a computational study of petcoke and olive pomace (OP) co-combustion in a cement rotary kiln burner, established on the commercial CFD software ANSYS FLUENT. This study presents a useful key to choose an adequate simulation model that well predicts co-combustion problems. The performance of the K-ϵ turbulence models varieties (standard, Realizable, and Re-Normalization Group) combined with the hybrid finite rate/eddy dissipation model and the simple eddy dissipation model for predicting the co-combustion characteristics was investigated. The particle phase solutions are obtained using the Lagrangian approach. The performance of the mentioned model was evaluated based on the mesh accuracy, convergence time, temperature shape, and important chemical elements concentration. The predicted values of species concentrations and temperature are compared to the results obtained from the real case study and available literature. The standard K-ϵ model combined with the hybrid finite rate/eddy dissipation model gives the best results and the lower computational resources required for the 2-D model realized.
Anemia of geriatric patients
Authors: Gadó Klara , Khodier Malaz , Virág Andrea , Domján Gyula , Dörnyei Gabriella 
Published: June 2022

Abstract
Anemia is a common finding in the elderly. Approximately 10 percent of the elderly suffers from anemia. Anemia per se is an independent factor of mortality in older patients regardless its cause. Frailty is also frequent in geriatric patients. That means that there is a decreased reserve capacity to react to different stress factors including anemia. The frequent presence of heart failure and also impaired cerebrovascular circulation makes more difficult to tolerate anemia in older age.
Anemia is a symptom, finding and treating the underlying cause is also important.
Treatment always depends on clinical findings: the more severe the symptoms, the more important to treat them. Severity of anemia depends not only the underlying cause, degree of anemia, co-morbidities and frailty of the patients, but also the speed of its development. Sudden blood loss due to an accident is less well tolerated than the same degree of anemia due to B12 deficiency.
Main causes of anemia in the elderly include nutritional deficiencies, chronic diseases, tumors, and certain hematological malignancies such as chronic lymphocytic leukemia, multiple myeloma, myelodysplastic syndrome.