bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Minat dan Kedisiplinan Siswa dengan Gaya Kognitif Field Indefendent terhadap Hasil Belajar Matematika Siswa SMK Farmasi Yamasi Makassar
Authors: Jainuddin Jainuddin , Salim S Soma , Sirajuddin Sirajuddin 
Published: July 2022

Tujuan dari penelitian ini adalah untuk mengetahui bagaiamana minat belajar dan kedisiplinan siswa dengan gaya kognitif field indefendent terhadap hasil belajar matematika siswa kelas X SMK Farmasi Yamasi Makassar.Penentuan sampel adalah dari seluruh siswa kelas X diberikan tes gaya kognitf Group Embedded Figures Test (GEFT), dan didapatkan hasil sebanyak 35 orang bergaya kognitif fiekd indefendnt. Metode yang digunakan adalah kuantitatif deskriptif. Dalam menganalisa data digunakan softwere IBM SPSS versi 25 for Windows. Analisis meliputi uji validitas dan uji relibilitas untuk angket minat dan kedisiplinan. Selanjutnya dilakuka uji prasyarat meliputi a) Uji Normalitas, b) Uji Linearitas, c) Uji Multikolinearitas serta . uji hipotesis yaitu analisis regresi ganda. Pada uji hipotesis didapatkan nilai sig untuk minat belajar dan kedisiplinan dengan taraf signifikan 5% (0,05) yaitu 0.000 < 0,05 artinya minat belajar dan kedisiplinan berpengaruh terhadap hasil belajar matematika siswa dengan gaya kognitif field indefendent pada kelas X SMK Farmasi Yamasi Makassar. Besar pengaruhnya yaitu 53,9%, selebihnya dipengaruhi oleh faktor lain. Kesimpulan penelitian ini yaitu minat belajar dan kedisiplinan berpengaruh terhadap hasil belajar matematika siswa dengan gaya kognitif field indefendent pada kelas X SMK Farmasi Yamasi Makassar.Kata Kunci: Field Indefendent, Minat Belajar, Kedisiplinan
Gerakan Literasi Matematika dalam Peningkatan Kemampuan Pemecahan Masalah Matematis Siswa
Authors: Zahroh Halimatus , Hafidah Hafidah , Dhofir Dhofir , Zayyadi Moh 
Published: July 2022

Literasi telah menjadi perbincangan hangat dalam dunia internasional dan menjadi harapan besar dunia.Berbagai pihak gencar melakukan penilaian literasi dan berusaha mencari cara untuk meningkatkan literasi di berbagai negara. Begitu juga di Indonesia, pemerintah telah menyadari bahwa untuk menghadapi dunia yang semakin kompleks diperlukan generasi muda yang tanggap dan kritis. Dunia pendidikan matematika pun tidak ingin ketinggalan dalam meningkatkan dan mengembangkan kemampuan literasi matematika siswa. PISA (Program for International Student Assessment) adalah penilaian tiga tahunan bagi siswa yang berusia 15 tahun yang mendekati akhir belajarnya di seluruh dunia dengan tujuan untuk menilai pengetahuan dan keterampilan siswa yang meliputi literasi matematika, literasi sains dan literasi membaca sebagai seorang generasi yang dapat bersaing penuh dan ikut berpartisipasi dalam dunia globalisasi dan masyarakat modern, dengan fokus penilaiannya bukan tentang apa yang siswa ketahui, melainkan apa yang bisa mereka lakukan dengan yang mereka ketahui.Literasi matematika dapat diartikan sebagai kemampuan setiap individu untuk merumuskan, menafsirkan, menalar, menginterpretasikan, mengkomunikasikan, dan menjelaskan pemecahan masalah dalam kehidupan sehari-hari secara efektif dan efisien.
Uluslararası Hukuk ve Türk Hukuku Açısından Göçmen Kaçakçılığı Suçunda “Maddi Menfaat Elde Etme Amacı” Kavramı
Authors: YAŞAR Yusuf , GÜNEŞ Umut 
Published: July 2022

Sınıraşan Örgütlü Suçlara Karşı Birleşmiş Milletler Sözleşmesine Ek Kara, Deniz ve Hava Yoluyla Göçmen Kaçakçılığına Karşı Protokol, her taraf ülkeye göçmen kaçakçılığını suç haline getirme yükümlülüğünü getirmiştir.
Protokole göre göçmen kaçakçılığı ancak “dolaylı ya doğrudan mali ya da diğer maddi menfaat elde etme amacıyla” yapıldığında oluşmaktadır. Bu tanıma karşın bazı ülkeler göçmenlere maddi menfaat beklentisi olmadan yapılan yardımları dahi suç haline getirmişlerdir.
Çalışmamızın amacı Göçmen Kaçakçılığı Protokolünün göçmen kaçakçılığını nasıl tanımladığını açıklamak ve bazı Avrupa ülkeleri ile Türkiye’nin “dolaylı ya doğrudan mali ya da diğer maddi menfaat elde etme amacı”nı yasalarına nasıl yansıttıklarını incelemektir.
Hello, world! VIVA+: A human body model lineup to evaluate sex-differences in crash protection
Authors: John Jobin , Klug Corina , Kranjec Matej , Svenning Erik , Iraeus Johan 
Published: July 2022

Finite element Human Body Models are increasingly becoming vital tools for injury assessment and are expected to play an important role in virtual vehicle safety testing. With the aim of realizing models to study sex-differences seen in the injury- and fatality-risks from epidemiology, we developed models that represent an average female and an average male. The models were developed with an objective to allow tissue-based skeletal injury assessment, and thus non-skeletal organs and joints were defined with simplified characterizations to enhance computational efficiency and robustness. The model lineup comprises female and male representations of (seated) vehicle occupants and (standing) vulnerable road users, enabling the safety assessment of broader segments of the road user population. In addition, a new workflow utilized in the model development is presented. In this workflow, one model (the seated female) served as the base model while all the other models were generated as closely-linked derivative models, differing only in terms of node coordinates and mass distribution. This approach opens new possibilities to develop and maintain further models as part of the model lineup, representing different types of road users to reflect the ongoing transitions in mobility patterns (like bicyclists and e-scooter users). In this paper, we evaluate the kinetic and kinematic responses of the occupant and standing models to blunt impacts, mainly on the torso, in different directions (front, lateral, and back). The front and lateral impacts to the thorax showed responses comparable to the experiments, while the back impact varied with the location of impact (T1 and T8). Abdomen bar impact showed a stiffer load-deflection response at higher intrusions beyond 40 mm, because of simplified representation of internal organs. The lateral shoulder impact responses were also slightly stiffer, presumably from the simplified shoulder joint definition. This paper is the first in a series describing the development and validation of the new Human Body Model lineup, VIVA+. With the inclusion of an average-sized female model as a standard model in the lineup, we seek to foster an equitable injury evaluation in future virtual safety assessments.
Low Molecular Weight Sericin Enhances the In Vitro of Immunological Modulation and Cell Migration
Authors: Cherng Juin-Hong , Chang Shu-Jen , Chiu Yaw-Kwan , Chiu Yu-Hsiang , Fang Tong-Jing , Chen Hsiang-Cheng 
Published: July 2022

Sericin, a waste product of the silk textile industry, has favorable physicochemical and biological properties. In this study, we extracted a low molecular weight (MW) sericin (LMW-sericin; below 10 kDa) by a performing high-temperature and high-pressure method and confirmed the MW using matrix-assisted laser desorption ionization-time of flight and liquid chromatography–mass spectrometry. Furthermore, we determined its biological effects on macrophages and human adipose stem cells (hASCs) as cell models to investigate the biocompatibility, immunomodulation behavior, and potential signaling pathway-related wound healing via analyses of gene expression of focal adhesion and human cytokines and chemokines using quantitative real-time polymerase chain reaction and cytokine assay. LMW-sericin showed good biocompatibility both in macrophages and hASCs. Macrophages cultured with 0.1 mg/ml LMW-sericin displayed an improved inflammatory response shown by the upregulation of CXCL9, IL12A, BMP7, and IL10, which developed Th1 and Th2 balance. LMW-sericin also improved the differentiation of macrophages toward the M2 phenotype by significantly enhancing the expression of Arg-1, which is conducive to the repair of the inflammatory environment. Moreover, the gene expression of hASCs showed that LMW-sericin promoted the secretion of beneficial adhesion molecules that potentially activate the gene transcription of differentiation and migration in hASCs, as well as significantly enhanced the levels of PKCβ1, RhoA, and RasGFR1 as fruitful molecules in wound healing. These findings provide insights into LMW-sericin application as a potential biomaterial for wound management.
Molecular and Cellular Response of the Myocardium (H9C2 Cells) Towards Hypoxia and HIF-1α Inhibition
Authors: Osuru Hari Prasad , Lavallee Matthew , Thiele Robert H. 
Published: July 2022

IntroductionOxidative phosphorylation is an essential feature of Animalian life. Multiple adaptations have developed to protect against hypoxia, including hypoxia-inducible-factors (HIFs). The major role of HIFs may be in protecting against oxidative stress, not the preservation of high-energy phosphates. The precise mechanism(s) of HIF protection is not completely understood.Materials and MethodsTo better understand the role of hypoxia-inducible-factor-1, we exposed heart/myocardium cells (H9c2) to both normoxia and hypoxia, as well as cobalt chloride (prolyl hydroxylase inhibitor), echniomycin (HIF inhibitor), A2P (anti-oxidant), and small interfering RNA to beclin-1. We measured cell viability, intracellular calcium and adenosine triphosphate, NADP/NADPH ratios, total intracellular reactive oxidative species levels, and markers of oxidative and antioxidant levels measured.ResultsHypoxia (1%) leads to increased intracellular Ca2+ levels, and this response was inhibited by A2P and echinomycin (ECM). Exposure of H9c2 cells to hypoxia also led to an increase in both mRNA and protein expression for Cav 1.2 and Cav 1.3. Exposure of H9c2 cells to hypoxia led to a decrease in intracellular ATP levels and a sharp reduction in total ROS, SOD, and CAT levels. The impact of hypoxia on ROS was reversed with HIF-1 inhibition through ECM. Exposure of H9c2 cells to hypoxia led to an increase in Hif1a, VEGF and EPO protein expression, as well as a decrease in mitochondrial DNA. Both A2P and ECM attenuated this response to varying degrees.ConclusionHypoxia leads to increased intracellular Ca2+, and inhibition of HIF-1 attenuates the increase in intracellular Ca2+ that occurs with hypoxia. HIF-1 expression leads to decreased adenosine triphosphate levels, but the role of HIF-1 on the production of reactive oxidative species remains uncertain. Anti-oxidants decrease HIF-1 expression in the setting of hypoxia and attenuate the increase in Ca2+ that occurs during hypoxia (with no effect during normoxia). Beclin-1 appears to drive autophagy in the setting of hypoxia (through ATG5) but not in normoxia. Additionally, Beclin-1 is a powerful driver of reactive oxidative species production and plays a role in ATP production. HIF-1 inhibition does not affect autophagy in the setting of hypoxia, suggesting that there are other drivers of autophagy that impact beclin-1.
Understanding Study Drug Discontinuation Through EUCLID
Authors: Weissler E. Hope , Mulder Hillary , Rockhold Frank W. , Baumgartner Iris , Norgren Lars , Blomster Juuso , Katona Brian G. , Fowkes F. Gerry R. , Mahaffey Kenneth , Bonaca Marc , Patel Manesh R. , Jones W. Schuyler 
Published: July 2022

IntroductionDisparities in the care and outcomes of peripheral artery disease (PAD) have been well-established. In part this is due to disparities in enrollment of PAD trial cohorts. However, less attention has been paid to non-random protocol non-adherence after enrollment, which may lead to inaccurate estimates of treatment effects and reduce generalizability of study results. We aimed to ascertain characteristics associated with premature study drug discontinuation in a PAD cohort.MethodsUsing data from EUCLID (Examining Use of Ticagrelor in Peripheral Artery Disease), factors associated with study drug discontinuation were assessed using univariable and multivariable Cox proportional hazards models with time to study drug discontinuation as the outcome of interest. Relationships between study drug discontinuation and major adverse cardiovascular events (MACE; cardiovascular death, myocardial infarction, ischemic stroke), major adverse limb events (MALE; acute limb ischemia, major amputation, and lower extremity revascularization), and all-cause hospitalization were assessed.ResultsOf 13,842 eligible EUCLID participants, 3,886 (28.1%) prematurely and permanently discontinued study drug over a maximum follow-up of 42 months (annualized rate of 13.2 discontinuations per 100 patient-years). In a multivariable model, premature study drug discontinuation was associated with older age (aHR 1.16, 95%CI 1.14–1.19), eligibility based on prior lower extremity revascularization rather than ABI/TBI criteria (aHR 1.14, 95%CI 1.06–1.23), CLI status (aHR 1.23, 95%CI 1.06–1.42), COPD (aHR 1.36, 95%CI 1.24–1.49), and geographic region. In a multivariable analysis, study drug discontinuation was significantly associated with MACE (aHR 3.27, 95%CI 2.90–3.67, p &lt; 0.001), MALE (aHR 1.84, 95%CI 1.63–2.07, p &lt; 0.001), and all-cause hospitalization (aHR 2.37, 95%CI 2.21–2.54) following study drug discontinuation.ConclusionsThis analysis of EUCLID demonstrates that premature, permanent discontinuation of study drug is relatively common in more than a quarter of PAD patients, is unevenly distributed based on geography and other baseline characteristics, and is associated with worse outcomes in a clinical trial context. Study teams leading future PAD trials may want to address the possibility of study drug discontinuation prospectively, as a proactive approach may help investigators to maintain study cohort diversity and representativeness without sacrificing power and precision.
A Systematic Review of the Outcomes, Level, Facilitators, and Barriers to Deep Self-Reflection in Public Health Higher Education: Meta-Analysis and Meta-Synthesis
Authors: Lim Raymond Boon Tar , Hoe Kenneth Wee Beng , Zheng Huili 
Published: July 2022

Based on 34 studies and to the best of our knowledge, this is the first systematic review consisting of a meta-analysis and a meta-synthesis to illustrate the various self-reflection formats used in public health higher education. Through this review, we aimed to (1) describe the range of self-reflection formats used in public health undergraduate education, (2) compare the level of reflectivity and outcomes of self-reflection according to the common formats of self-reflection used, and (3) compare the facilitators and barriers to deep self-reflection based on the common formats of self-reflection used. Most students were not engaging in reflection at a deep level according to the Mezirow's model of reflexivity. Both meta-analysis and meta-synthesis results revealed self-reflection enhanced self-confidence, professional identity, and professional development as well as improved understanding of public health related topics in these students. Future educational programmes should consider the common facilitators to deep self-reflection, i.e., advocacy on the importance of reflection by instructors and provision of guidance to students and the common barriers, i.e., perception by instructors/students to be time consuming and the imbalance in power relationship between instructors and students. Because perceptions of learning environments varied between institutions, programs, teachers and students, efforts to evaluate the implementation feasibility of these facilitators and barriers need to take place across the different levels. As a start, peer ambassadors or champions could be appointed at the student level to change the common perception that performing deep self-reflection was time consuming. Similarly, at the teacher level, faculty learning communities could be set up for like-minded educators to advocate on the importance of reflection and to share their experience on balancing the power relationship between instructors and students.Systematic Review Registration: PROSPERO, identifier: CRD42021255714.
Late-afternoon endurance exercise is more effective than morning endurance exercise at improving 24-h glucose and blood lipid levels
Authors: Kim Hyeon-Ki , Furuhashi Shota , Takahashi Masaki , Chijiki Hanako , Nanba Takuya , Inami Takayuki , Radak Zsolt , Sakamoto Shizuo , Shibata Shigenobu 
Published: July 2022

BackgroundGlucose and lipid tolerance reportedly exhibit diurnal variations, being lower in the evening than in the morning. Therefore, the effects of exercise on glucose and blood lipid levels at different times of the day may differ. This study aimed to investigate the effects of short-term endurance exercise intervention in the morning versus late afternoon on 24-h blood glucose variability and blood lipid levels.MethodsTwelve healthy young men participated in a randomized crossover trial. The participants were assigned to morning (09:00–11:00) or late afternoon (16:00–18:00) endurance exercise for a week, consisting of supervised exercise sessions on Mondays, Wednesdays, and Fridays. In the morning and evening trials, the participants walked for 60 min on a treadmill at approximately 60% of maximal oxygen uptake (VO2max). Following a 2-week wash-out period, the participants performed the exercise training regimen at another time point. Continuous glucose monitoring was used to evaluate blood glucose fluctuations during each 24-h trial period. Blood samples were collected before and after each intervention to examine blood lipid and hormonal responses.ResultsExamination of the area under the curve (AUC) of the glucose level changes for 24 h after the late afternoon versus morning exercise intervention revealed significantly lower values for the former versus the latter (P &lt; 0.01). The AUC of glucose level changes after each meal was also lower after the late afternoon versus morning intervention, and significantly lower values were observed in the late afternoon versus morning trial for breakfast and dinner (P &lt; 0.05, P &lt; 0.01). In addition, a significant decrease in triglycerides (TG) and TG/high-density lipoprotein cholesterol (HDL-C) was noted after versus before the late afternoon intervention (P &lt; 0.05).ConclusionsThese results suggest that late afternoon endurance exercise is more effective than morning endurance exercise at improving 24-h glucose and triglyceride levels.
Rice Straw Vermicompost Enriched With Cellulolytic Microbes Ameliorate the Negative Effect of Drought in Wheat Through Modulating the Morpho-Physiological Attributes
Authors: Ahmad Ali , Aslam Zubair , Hussain Saddam , Bibi Amir , Khaliq Abdul , Javed Talha , Hussain Sadam , Alotaibi Saqer S. , Kalaji Hazem M. , Telesiński Arkadiusz , Iwai Chuleemas Boonthai , Kumar Uttam 
Published: July 2022

Wheat growth and productivity are unfavorably pretentious by a lack of sufficient water (drought or water deficit) worldwide. Drought stress significantly affects all the morpho-physiological and biochemical characteristics and the agronomical yield of wheat. Different management approaches have been adopted to cope with the negative effects of water deficit. Soil-applied vermicompost is helpful in improving the growth and developmental processes of wheat under water deficit conditions. Therefore, a trial was carried out to optimize the best amount of vermicompost and to assess its role in ameliorating the negative effects of drought for sustainable crop production. The treatments consisted of 1) two contrasting wheat cultivars Faisalabad-08 (drought-tolerant) and Galaxy-13 (drought-sensitive), 2) drought with three levels [D0= 70% of field capacity (no drought), D1= 45% of field capacity (mild drought), and D2= 30% of field capacity (severe drought)] and 3) cellulolytic microbe-enriched vermicompost prepared from rice straw with four levels (VT0= Control, VT1= 4 t ha−1, VT2= 6 t ha−1, and VT3= 8 t ha−1). Data on various morphological, physiological, and biochemical parameters were recorded from sowing to crop harvesting. In this study, it was demonstrated that all these parameters were negatively affected by moisture deficit conditions. The application of vermi-fertilizer significantly increased (p&lt; 0.05) the aforementioned parameters of wheat in both the absence and presence of drought. Under severe drought, VT2treatment increased the seedling length by 14.02–26.14%, fresh weight by 15.16–22.91%, and dry weight by 0.37–28.20% in both cultivars compared with control. In addition, VT2treatment reduced the leaf water potential by 6.36 and 3.36%, leaf osmotic potential by 1.74 and 1.68%, and increased the turgor potential by 4.83 and 3.36%, and photosynthetic rate by 18.59 and 26.42% in Faislabad-08 and Galaxy-13, respectively, over control. We concluded that the application of vermicompost is a valuable approach to alleviate the adverse impacts of water stress on wheat.
Comprehensive Analysis of Prognostic Value and Immune Infiltration of Ficolin Family Members in Hepatocellular Carcinoma
Authors: Sun Liang , Yu Shian , Dong Cairong , Wu Zhengyi , Huang He , Chen Zhendong , Wu Zhipeng , Yin Xiangbao 
Published: July 2022

Objective: Ficolin (FCN) family proteins are part of the innate immune system, play a role as recognition molecules in the complement system, and are associated with tumor development. The mechanism of its role in immunotherapy of hepatocellular carcinoma (HCC) is unclear.Methods: In this study, we used the TCGA database, HPA database, Gene Expression Profile Interaction Analysis (GEPIA), Kaplan-Meier plotter, TCGAportal, cBioPortal, GeneMANIA, TIMER, and TISIDB to analyze Ficolin family proteins (FCN1, FCN2 and FCN3, FCNs) in patients with hepatocellular carcinoma for differential expression, prognostic value, genetic alterations, functional enrichment, and immune factor correlation analysis.Results: The expression levels of FCN1/2/3 were significantly reduced in patients with HCC. Among them, FCN3 showed significant correlation with Overall Survival (OS), Progressive Free Survival (PFS) and Relapse Free Survival (RFS) in HCC. FCN1 and FCN3 may be potential prognostic markers for survival in patients with HCC. In addition, the functions of differentially expressed FCNs were mainly related to complement activation, immune response, apoptotic cell clearance and phagocytosis. FCNs were found to be significantly correlated with multiple immune cells and immune factors. Expression of FCN1 and FCN3 differed significantly in the immune and stromal cell component scores of HCC. analysis of the tumor mutation burden (TMB) and microsatellite instability (MSI) of FCNs with pan-cancer showed that FCN3 was significantly correlated with both.Conclusions: Our study provides new insights into the link between the FCN family and immunotherapy for HCC, and FCN3 may serve as a prognostic biomarker for HCC.