bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal trends in abdominal aortic aneurysmal disease: a nationwide cohort study on cardiovascular morbidity and medical cardioprotective therapy
Authors: Nicolajsen Chalotte W , Søgaard Mette , Eldrup Nikolaj , Jensen Martin , Larsen Torben B , Goldhaber Samuel Z , Nielsen Peter B 
Published: June 2022

Abstract

Aims
Abdominal aortic aneurysmal disease is associated with increased risk of cardiovascular morbidity and death, which potentially can be reduced with cardioprotective medical therapy. The aim of this study was to observe temporal trends in prevalence and incidence of cardiovascular comorbidity as well as use of medical cardioprotective treatment in patients diagnosed with abdominal aortic aneurysmal disease.

Methods and results
This was a population-based cohort study based on data from national health registries, including all patients diagnosed with abdominal aortic aneurysms between 1998 and 2018. Data were stratified into four time periods (1999–2003, 2004–2008, 2009–2013, and 2014–2018) to illustrate trends over time. Outcome measures were (i) cardiovascular comorbidity and medical cardioprotective therapy at time of diagnosis, (ii) new admissions for atherosclerotic cardiovascular disease, and (iii) all-cause mortality after 2-year follow-up. The study cohort included 33 296 individuals. Mean age was 74 years. Prevalence of atherosclerotic cardiovascular comorbidity at diagnosis decreased from 41.5 to 32.6%. Use of statins increased from 17.9 to 66.9%, antiplatelets from 45.6 to 63.3%, and combined therapy with both antiplatelets and statins from 11.3 to 44.8%, and from 12.1 to 50.7% when anticoagulant therapy was included. Developments in medication use plateaued after 2013. Prevalence and incidence of atherosclerotic cardiovascular disease decreased through all four time periods. The same applied to all-cause mortality, which decreased from 24.3 to 12.4 deaths (per 100 person-years).

Conclusion
In patients diagnosed with abdominal aortic aneurysm, cardiovascular comorbidity at diagnosis, risk of future cardiovascular events, and all-cause mortality is decreasing. Nevertheless, cardiovascular burden and mortality rates remain substantial, and medical cardioprotective therapy can be further improved.
Walking for Cognitive Health: Previous Parity Moderates the Relationship Between Self-Reported Walking and Cognition
Authors: Barha Cindy K , Best John R , Rosano Caterina , Yaffe Kristine , Catov Janet M , Liu-Ambrose Teresa 
Published: June 2022

AbstractBackgroundOlder females show greater cognitive gains from physical activity (PA) than males, which may be related to long-term consequences of female-specific reproductive events (eg, pregnancy) on cognitive health.MethodsTo determine whether previous parity could moderate the relationship between PA and cognitive decline in older women, we conducted secondary analyses of data from the Health, Aging, and Body Composition Study. We tested whether the association between average PA over 10 years and cognition (Modified Mini-Mental State Examination [3MS]) and executive functioning (digit symbol substitution test [DSST]) over 10 years varied by previous parity (nulliparity, low parity, medium parity, and grand multiparity). An analysis of covariance was performed with cognition (average and change over 10 years) as the dependent variables, parity as a categorical predictor, average PA as a continuous predictor, and a set of relevant covariates.ResultsSignificant interactions were found between PA and parity group for all 4 comparisons: average 3MS (p = .014), average DSST (p = .032), change in 3MS (p = .016), and change in DSST (p = .017). Simple slope analyses indicated the positive relationship between PA and average 3MS and DSST was only significant in the nulliparity and grand multiparity groups, and the positive relationship between PA and change in 3MS and DSST was only significant in the grand multiparity group.ConclusionThe findings suggest the relationship between self-reported walking and cognitive performance was strongest in the groups at risk for cognitive decline and dementia, the nulliparous and grand multiparous groups.
Incidence of Respiratory Syncytial Virus Lower Respiratory Tract Infections During the First 2 Years of Life: A Prospective Study Across Diverse Global Settings
Authors: Langley Joanne M , Bianco Veronique , Domachowske Joseph B , Madhi Shabir A , Stoszek Sonia K , Zaman Khalequ , Bueso Agustin , Ceballos Ana , Cousin Luis , D’Andrea Ulises , Dieussaert Ilse , Englund Janet A , Gandhi Sanjay , Gruselle Olivier , Haars Gerco , Jose Lisa , Klein Nicola P , Leach Amanda , Maleux Koen , Nguyen Thi Lien Anh , Puthanakit Thanyawee , Silas Peter , Tangsathapornpong Auchara , Teeratakulpisarn Jamaree , Vesikari Timo , Cohen Rachel A 
Published: June 2022

AbstractBackgroundThe true burden of lower respiratory tract infections (LRTIs) due to respiratory syncytial virus (RSV) remains unclear. This study aimed to provide more robust, multinational data on RSV-LRTI incidence and burden in the first 2 years of life.MethodsThis prospective, observational cohort study was conducted in Argentina, Bangladesh, Canada, Finland, Honduras, South Africa, Thailand, and United States. Children were followed for 24 months from birth. Suspected LRTIs were detected via active (through regular contacts) and passive surveillance. RSV and other viruses were detected from nasopharyngeal swabs using PCR-based methods.ResultsOf 2401 children, 206 (8.6%) had 227 episodes of RSV-LRTI. Incidence rates (IRs) of first episode of RSV-LRTI were 7.35 (95% confidence interval [CI], 5.88–9.08), 5.50 (95% CI, 4.21–7.07), and 2.87 (95% CI, 2.18–3.70) cases/100 person-years in children aged 0–5, 6–11, and 12–23 months. IRs for RSV-LRTI, severe RSV-LRTI, and RSV hospitalization tended to be higher among 0–5 month olds and in lower-income settings. RSV was detected for 40% of LRTIs in 0–2 month olds and for approximately 20% of LRTIs in older children. Other viruses were codetected in 29.2% of RSV-positive nasopharyngeal swabs.ConclusionsA substantial burden of RSV-LRTI was observed across diverse settings, impacting the youngest infants the most.Clinical Trials Registration. NCT01995175.
People With Human Immunodeficiency Virus Receiving Suppressive Antiretroviral Therapy Show Typical Antibody Durability After Dual Coronavirus Disease 2019 Vaccination and Strong Third Dose Responses
Authors: Lapointe Hope R , Mwimanzi Francis , Cheung Peter K , Sang Yurou , Yaseen Fatima , Umviligihozo Gisele , Kalikawe Rebecca , Speckmaier Sarah , Moran-Garcia Nadia , Datwani Sneha , Duncan Maggie C , Agafitei Olga , Ennis Siobhan , Young Landon , Ali Hesham , Ganase Bruce , Omondi F Harrison , Dong Winnie , Toy Junine , Sereda Paul , Burns Laura , Costiniuk Cecilia T , Cooper Curtis , Anis Aslam H , Leung Victor , Holmes Daniel T , DeMarco Mari L , Simons Janet , Hedgcock Malcolm , Prystajecky Natalie , Lowe Christopher F , Pantophlet Ralph , Romney Marc G , Barrios Rolando , Guillemi Silvia , Brumme Chanson J , Montaner Julio S G , Hull Mark , Harris Marianne , Niikura Masahiro , Brockman Mark A , Brumme Zabrina L 
Published: June 2022

AbstractBackgroundLonger-term humoral responses to 2-dose coronavirus disease 2019 (COVID-19) vaccines remain incompletely characterized in people living with human immunodeficiency virus (HIV) (PLWH), as do initial responses to a third dose.MethodsWe measured antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein receptor-binding domain, angiotensin-converting enzyme 2 (ACE2) displacement, and viral neutralization against wild-type and Omicron strains up to 6 months after 2-dose vaccination, and 1 month after the third dose, in 99 PLWH receiving suppressive antiretroviral therapy and 152 controls.ResultsAlthough humoral responses naturally decline after 2-dose vaccination, we found no evidence of lower antibody concentrations or faster rates of antibody decline in PLWH compared with controls after accounting for sociodemographic, health, and vaccine-related factors. We also found no evidence of poorer viral neutralization in PLWH after 2 doses, nor evidence that a low nadir CD4+ T-cell count compromised responses. Post–third-dose humoral responses substantially exceeded post–second-dose levels, though Omicron-specific responses were consistently weaker than responses against wild-type virus. Nevertheless, post–third-dose responses in PLWH were comparable to or higher than controls. An mRNA-1273 third dose was the strongest consistent correlate of higher post–third-dose responses.ConclusionPLWH receiving suppressive antiretroviral therapy mount strong antibody responses after 2- and 3-dose COVID-19 vaccination. Results underscore the immune benefits of third doses in light of Omicron.
The Influence of Budgets on Consumer Spending
Authors: Lukas Marcel F , Howard Ray Charles “Chuck” 
Published: June 2022

Abstract
Foundational research in marketing and behavioral economics has revealed a great deal about the psychology of budgeting. However, little is known about the extent to which budgets do (or do not) influence consumers’ real-world spending. The present research addresses this gap in the literature using naturally occurring budgeting and spending data provided by a popular personal finance app in the UK, a field experiment conducted with members of a Canadian credit union, and a financial diary study conducted with consumers in the US. Budget compliance is generally weak because budgets are wildly optimistic. However, optimistic budgets do help consumers reduce their spending. Moreover, the influence of budgets on spending is surprisingly sticky: consumers continue to reduce their spending six months after setting a budget, even though spending remains over-budget. Impulsive consumers exhibit worse budget compliance than less-impulsive consumers. However, counterintuitively, this is predominately because more impulsive consumers set lower budgets than less-impulsive consumers, not because they spend more. Finally, we provide evidence that budgets influence spending across several theory-informing psychographic variables. Taken together, these findings show that budgets can be both wildly optimistic and highly influential and that beliefs about the nature of consumers’ budgets require updating.
Gender Differences in Tournament Choices: Risk Preferences, Overconfidence, or Competitiveness?
Authors: van Veldhuizen Roel 
Published: June 2022

Abstract
A long line of laboratory experiments has found that women are less likely to sort into competitive environments. Although part of this effect may be explained by gender differences in risk attitudes and self-confidence, previous studies have attributed the majority of the gender gap to gender differences in a competitiveness trait. I re-examine this result using a novel experiment that allows me to separate competitiveness from alternative explanations using causal treatments. In contradiction to the main conclusion drawn in a long literature, my results imply that the entire gender gap is driven by gender differences in risk attitudes and self-confidence, which has implications for policy and research.
Time Variation in Cash Flows and Discount Rates
Authors: Cenesizoglu Tolga , Ibrushi Denada 
Published: June 2022

AbstractWe analyze the decomposition of the conditional, rather than the unconditional, variance of market returns based on an extension of the standard Campbell–Shiller approach. The relative importance of cash flow and discount rate news in determining the conditional variance of market returns exhibits significant variation over time and relates to economic conditions. The components of the conditional market variance outperform several benchmark variables, including the conditional market variance itself, in forecasting future market returns and realized variance across different horizons. The forecasts based on the conditional market variance components also provide sizable economic benefits compared with benchmark forecasts in an out-of-sample portfolio exercise where a myopic investor allocates her wealth between the market portfolio and a risk-free asset across different holding periods.
The size–luminosity relation of lensed galaxies at z ∼ 6–9 in the Hubble Frontier Fields
Authors: Yang Lilan , Leethochawalit Nicha , Treu Tommaso , Roberts-Borsani Guido , Bradač Maruša , Birrer Simon , Castellano Marco , Merlin Emiliano , Fontana Adriano , Amorin Ricardo , Trenti Michele 
Published: June 2022

ABSTRACT
We measure the size–luminosity relation of photometrically selected galaxies within the redshift range z ∼ 6–9, using galaxies lensed by six foreground Hubble Frontier Fields (HFF) clusters. The power afforded by strong gravitational lensing allows us to observe fainter and smaller galaxies than in blank fields. We select our sample of galaxies and obtain their properties, e.g. redshift, magnitude, from the photometrically derived ASTRODEEP catalogues. The intrinsic size is measured with the Lenstruction software, and completeness maps are created as a function of size and luminosity via the GLACiAR2 software. We perform a Bayesian analysis to estimate the intrinsic and incompleteness-corrected size–luminosity distribution, with parametrization re ∝ Lβ. We find slopes of $\beta =0.50^{+0.07}_{-0.07}$ at z ∼ 6 − 7 and $\beta =0.67^{+0.14}_{-0.15}$ at z ∼ 8.5, adopting the Bradac lens model. Our inferred slopes are consistent with other independent determinations of the size–luminosity relation from the HFF data set and steeper than that obtained from the bright galaxies in blank fields. We also investigate the systematic uncertainties associated with the choice of lens models, finding that the slopes of size–luminosity relations derived from different models are mutually consistent, i.e. modelling errors are not a significant source of discrepancy between the size–luminosity relation of blank and lensed fields.
Phosphorylation-dependent association of human chromatin protein PC4 to linker histone H1 regulates genome organization and transcription
Authors: Mustafi Pallabi , Hu Mingli , Kumari Sujata , Das Chandrima , Li Guohong , Kundu Tapas K 
Published: June 2022

Abstract
Human Positive Coactivator 4 (PC4) is a multifaceted chromatin protein involved in diverse cellular processes including genome organization, transcription regulation, replication, DNA repair and autophagy. PC4 exists as a phospho-protein in cells which impinges on its acetylation by p300 and thereby affects its transcriptional co-activator functions via double-stranded DNA binding. Despite the inhibitory effects, the abundance of phosphorylated PC4 in cells intrigued us to investigate its role in chromatin functions in a basal state of the cell. We found that casein kinase-II (CKII)-mediated phosphorylation of PC4 is critical for its interaction with linker histone H1. By employing analytical ultracentrifugation and electron microscopy imaging of in vitro reconstituted nucleosomal array, we observed that phospho-mimic (PM) PC4 displays a superior chromatin condensation potential in conjunction with linker histone H1. ATAC-sequencing further unveiled the role of PC4 phosphorylation to be critical in inducing chromatin compaction of a wide array of coding and non-coding genes in vivo. Concordantly, phospho-PC4 mediated changes in chromatin accessibility led to gene repression and affected global histone modifications. We propose that the abundance of PC4 in its phosphorylated state contributes to genome compaction contrary to its co-activator function in driving several cellular processes like gene transcription and autophagy.
Binding of the transcription activator-like effector augments transcriptional regulation by another transcription factor
Authors: Leben Katja , Strmšek Žiga , Lebar Tina , Verbič Anže , Dragovan Matej , Omersa Neža , Anderluh Gregor , Jerala Roman 
Published: June 2022

Abstract
DNA transcription is regulated by a range of diverse mechanisms and primarily by transcription factors that recruit the RNA polymerase complex to the promoter region on the DNA. Protein binding to DNA at nearby or distant sites can synergistically affect this process in a variety of ways, but mainly through direct interactions between DNA-binding proteins. Here we show that a Transcription Activator-Like Effector (TALE), which lacks an activation domain, can enhance transcription in mammalian cells when it binds in the vicinity of and without direct interaction with several different dimeric or monomeric transcription factors. This effect was observed for several TALEs regardless of the recognition sequences and their DNA-bound orientation. TALEs can exert an effect over the distance of tens of nucleotides and it also potentiated KRAB-mediated repression. The augmentation of transcriptional regulation of another transcription factor is characteristic of TALEs, as it was not observed for dCas9/gRNA, zinc finger, or Gal4 DNA-binding domains. We propose that this mechanism involves an allosteric effect exerted on DNA structure or dynamics. This mechanism could be used to modulate transcription but may also play a role in the natural context of TALEs.
Single seeds exhibit transcriptional heterogeneity during secondary dormancy induction
Authors: Krzyszton Michal , Yatusevich Ruslan , Wrona Magdalena , Sacharowski Sebastian P , Adamska Dorota , Swiezewski Szymon 
Published: June 2022

Abstract
Seeds are highly resilient to the external environment, which allows plants to persist in unpredictable and unfavorable conditions. Some plant species have adopted a bet-hedging strategy to germinate a variable fraction of seeds in any given condition, and this could be explained by population-based threshold models. Here, in the model plant Arabidopsis (Arabidopsis thaliana), we induced secondary dormancy (SD) to address the transcriptional heterogeneity among seeds that leads to binary germination/nongermination outcomes. We developed a single-seed RNA-seq strategy that allowed us to observe a reduction in seed transcriptional heterogeneity as seeds enter stress conditions, followed by an increase during recovery. We identified groups of genes whose expression showed a specific pattern through a time course and used these groups to position the individual seeds along the transcriptional gradient of germination competence. In agreement, transcriptomes of dormancy-deficient seeds (mutant of DELAY OF GERMINATION 1) showed a shift toward higher values of the germination competence index. Interestingly, a significant fraction of genes with variable expression encoded translation-related factors. In summary, interrogating hundreds of single-seed transcriptomes during SD-inducing treatment revealed variability among the transcriptomes that could result from the distribution of population-based sensitivity thresholds. Our results also showed that single-seed RNA-seq is the method of choice for analyzing seed bet-hedging-related phenomena.
Genome diploidization associates with cladogenesis, trait disparity, and plastid gene evolution
Authors: Zuo (左胜) Sheng , Guo (郭新异) Xinyi , Mandáková Terezie , Edginton Mark , Al-Shehbaz Ihsan A , Lysak Martin A 
Published: June 2022

AbstractAngiosperm genome evolution was marked by many clade-specific whole-genome duplication events. The Microlepidieae is one of the monophyletic clades in the mustard family (Brassicaceae) formed after an ancient allotetraploidization. Postpolyploid cladogenesis has resulted in the extant c. 17 genera and 60 species endemic to Australia and New Zealand (10 species). As postpolyploid genome diploidization is a trial-and-error process under natural selection, it may proceed with different intensity and be associated with speciation events. In Microlepidieae, different extents of homoeologous recombination between the two parental subgenomes generated clades marked by slow (“cold”) versus fast (“hot”) genome diploidization. To gain a deeper understanding of postpolyploid genome evolution in Microlepidieae, we analyzed phylogenetic relationships in this tribe using complete chloroplast sequences, entire 35S rDNA units, and abundant repetitive sequences. The four recovered intra-tribal clades mirror the varied diploidization of Microlepidieae genomes, suggesting that the intrinsic genomic features underlying the extent of diploidization are shared among genera and species within one clade. Nevertheless, even congeneric species may exert considerable morphological disparity (e.g. in fruit shape), whereas some species within different clades experience extensive morphological convergence despite the different pace of their genome diploidization. We showed that faster genome diploidization is positively associated with mean morphological disparity and evolution of chloroplast genes (plastid–nuclear genome coevolution). Higher speciation rates in perennials than in annual species were observed. Altogether, our results confirm the potential of Microlepidieae as a promising subject for the analysis of postpolyploid genome diploidization in Brassicaceae.
HISTONE DEACETYLASE 15 and MOS4-associated complex subunits 3A/3B coregulate intron retention of ABA-responsive genes
Authors: Tu Yi-Tsung , Chen Chia-Yang , Huang Yi-Sui , Chang Chung-Han , Yen Ming-Ren , Hsieh Jo-Wei Allison , Chen Pao-Yang , Wu Keqiang 
Published: June 2022

Abstract
Histone deacetylases (HDAs) play an important role in transcriptional regulation of multiple biological processes. In this study, we investigated the function of HDA15 in abscisic acid (ABA) responses. We used immunopurification coupled with mass spectrometry-based proteomics to identify proteins interacting with HDA15 in Arabidopsis (Arabidopsis thaliana). HDA15 interacted with the core subunits of the MOS4-associated complex (MAC), MAC3A and MAC3B, with interaction between HDA15 and MAC3B enhanced by ABA. hda15 and mac3a/mac3b mutants were ABA-insensitive during seed germination and hyposensitive to salinity. RNA sequencing analysis demonstrated that HDA15 and MAC3A/MAC3B co-regulate ABA-responsive intron retention (IR). Furthermore, HDA15 reduced the histone acetylation level of genomic regions near ABA-responsive IR sites and the association of MAC3B with ABA-responsive pre-mRNA was dependent on HDA15. Our results indicate that HDA15 is involved in ABA responses by interacting with MAC3A/MAC3B to mediate splicing of introns.