bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with mortality in hospitalized cardiovascular disease patients infected with COVID‐19
Authors: Alizadehsani Roohallah , Eskandarian Rahimeh , Behjati Mohaddeseh , Zahmatkesh Mehrdad , Roshanzamir Mohamad , Izadi Navid H. , Shoeibi Afshin , Haddadi Azadeh , Khozeimeh Fahime , Sani Fariba A. , Sani Zahra A. , Roshanzamir Zahra , Khosravi Abbas , Nahavandi Saeid , Sarrafzadegan Nizal , Islam Sheikh Mohammed Shariful 
Published: January 2022

AbstractIntroductionTo reduce mortality in hospitalized patients with COVID‐19 and cardiovascular disease (CVD), it is necessary to understand the relationship between patient's symptoms, risk factors, and comorbidities with their mortality rate. To the best of our knowledge, this paper is the first which take into account the determinants like risk factors, symptoms, and comorbidities leading to mortality in CVD patients who are hospitalized with COVID‐19.MethodsThis study was conducted on 660 hospitalized patients with CVD and COVID‐19 recruited between January 2020 and January 2021 in Iran. All patients were diagnosed with the previous history of CVD like angina, myocardial infarction, heart failure, cardiomyopathy, abnormal heart rhythms, and congenital heart disease before they were hospitalized for COVID‐19. We collected data on patient's signs and symptoms, clinical and paraclinical examinations, and any underlying comorbidities. t test was used to determine the significant difference between the two deceased and alive groups. In addition, the relation between pairs of symptoms and pairs of comorbidities has been determined via correlation computation.ResultsOur findings suggest that signs and symptoms such as fever, cough, myalgia, chest pain, chills, abdominal pain, nausea, vomiting, diarrhea, and anorexia had no impact on patients' mortality. There was a significant correlation between COVID‐19 cardiovascular patients' mortality rate and symptoms such as headache, loss of consciousness (LOC), oxygen saturation less than 93%, and need for mechanical ventilation.ConclusionsOur results might help physicians identify early symptoms, comorbidities, and risk factors related to mortality in CVD patients hospitalized for COVID‐19.
Modeling pathways to non‐suicidal self‐injury: The roles of perfectionism, negative affect, rumination, and attention control
Authors: Tonta Kate E. , Boyes Mark , Howell Joel , McEvoy Peter , Johnson Andrew , Hasking Penelope 
Published: January 2022

AbstractObjectiveUsing the Emotional Cascade Model as a theoretical framework, this study tested whether the relationship between perfectionism and non‐suicidal self‐injury (NSSI) operates through rumination and negative affect. Additionally, we tested whether the associations between perfectionism and both rumination and negative affect are moderated by attention control.MethodsUsing a correlational cross‐sectional design, adults aged 18–25 with (N = 197) and without (N = 271) a history of NSSI completed measures of perfectionism, rumination, negative affect, attention control, and NSSI.ResultsPerfectionism was directly associated with increased odds of NSSI, and indirectly associated with odds of NSSI through rumination and negative affect. The relationship between perfectionism and rumination was moderated by attention focusing, such that the relationship was stronger for individuals who were higher in attention focusing.ConclusionIntegrating perfectionism and attention with existing models of NSSI may improve understanding of the factors contributing to NSSI and offers insights into future clinical directions.
Pharmacokinetic/Pharmacodynamic Parameters of Linezolid in the Epithelial Lining Fluid of Patients With Sepsis
Authors: Wu Changde , Zhang Xiwen , Xie Jianfeng , Li Qing , He Jie , Hu Linlin , Wang Haofei , Liu Airan , Xu Jingyuan , Yang Congshan , Yang Yi , Qiu Haibo , Huang Yingzi 
Published: January 2022

AbstractThe aim of this study was to investigate the pharmacokinetic/pharmacodynamic parameters of linezolid in both the plasma and epithelial lining fluid (ELF) of patients with pneumonia‐induced sepsis. Blood specimens and bronchoalveolar lavage samples were collected at defined time points after administration of linezolid. The concentration in the ELF was calculated by urea dilution method. PK parameters were calculated, and probability of target attainment was evaluated by Monte Carlo simulations. Twenty‐three patients were enrolled, 8 of whom had septic shock. The maximum concentration of linezolid was higher in the ELF than in the plasma (36.02 ± 13.17 vs 19.51±4.83 mg/L, P < .001) in all of the patients. In patients with septic shock, the maximum concentration in the ELF was significantly higher than that in the non–septic shock group (45.25 ± 11.70 vs 31.10 ± 11.38 mg/L, P = .01), while there was no significant difference in the plasma. The corresponding probability of target attainment values were 90.5% and 65.1% in ELF and plasma, respectively, with a minimum inhibitory concentration of 2 mg/L, which were 99.9% in the ELF in the patients with septic shock. Linezolid possesses an efficient penetration into the ELF of patients with pneumonia‐induced sepsis with mechanical ventilation. When minimum inhibitory concentration ≤ 2 mg/L, 600 mg of linezolid every 12 hours could achieve the optimal therapeutic targets in the ELF rather than in the plasma of patients with pneumonia‐induced sepsis.
Fabrication of green poly (L‐lactic acid) hybrid membrane through incorporation of functionalized natural halloysite nanotubes
Authors: Wang Baoyu , He Huifen , Li Yuling , Liu Congjun , Bai Junjing , Zhou Xiumiao , Li Jingjing , Wang Yufen 
Published: January 2022

AbstractBACKGROUNDMembrane technology has attracted increasing interest in the field of separation and purification. Unfortunately, conventional membrane materials are usually derived from non‐renewable fossil resources that are difficult to degrade at the end of their life. In this work, as a sustainable alternative to the conventional polymer membrane, the biobased ploy (L‐lactic acid) (PLLA) hybrid membrane was successfully fabricated through the incorporation of modified natural halloysite nanotubes (HNTs).RESULTSThe PLLA/HNT hybrid membranes were analysed by attenuated total reflectance‐Fourier transform infrared spectroscopy (ATR‐FTIR), X‐ray diffraction (XRD), scanning electron microscopy (SEM), X‐ray diffraction (XRD), and contact angle measurement. The pure water flux of the hybrid membrane increased from 140.3 to 329.7 L.m−3.h−1, while the bovine serum albumin (BSA) rejection ratio decreased from 94.3 to 82.7% with increasing HNT loading content from 0 to 1 wt%. Moreover, the addition of HNTs could also enhance the antifouling performance of the hybrid membrane.CONCLUSIONThe green PLLA/HNT hybrid membrane was successfully made from the recoverable and biodegradable PLLA and naturally occurring HNTs. Compared with the PLLA‐based membranes reported in the literature, the PLLA/HNT hybrid membranes presented relatively high permeability, moderate BSA rejection, and good antifouling performance. The green poly (L‐lactic acid) hybrid membranes hold great promise for practical application as they can contribute to a circular economy and sustainable development. © 2022 Society of Chemical Industry (SCI).
Extracellular vesicle‐mediated delivery of circDYM alleviates CUS‐induced depressive‐like behaviours
Authors: Yu Xiaoyu , Bai Ying , Han Bing , Ju Minzi , Tang Tianci , Shen Ling , Li Mingyue , Yang Li , Zhang Zhao , Hu Guoku , Chao Jie , Zhang Yuan , Yao Honghong 
Published: January 2022

AbstractMajor depressive disorder (MDD) is the most prevalent psychiatric disorder worldwide and severely limits psychosocial function and quality of life, but no effective medication is currently available. Circular RNAs (circRNAs) have been revealed to participate in the MDD pathological process. Targeted delivery of circRNAs without blood‐brain barrier (BBB) restriction for remission of MDD represents a promising approach for antidepressant therapy. In this study, RVG‐circDYM‐extracellular vesicles (RVG‐circDYM‐EVs) were engineered to target and preferentially transfer circDYM to the brain, and the effect on the pathological process in a chronic unpredictable stress (CUS) mouse model of depression was investigated. The results showed that RVG‐circDYM‐EVs were successfully purified by ultracentrifugation from overexpressed circDYM HEK 293T cells, and the characterization of RVG‐circDYM‐EVs was successfully demonstrated in terms of size, morphology and specific markers. Beyond demonstrating proof‐of‐concept for an RNA drug delivery technology, we observed that systemic administration of RVG‐circDYM‐EVs efficiently delivered circDYM to the brain, and alleviated CUS‐induced depressive‐like behaviours, and we discovered that RVG‐circDYM‐EVs notably inhibited microglial activation, BBB leakiness and peripheral immune cells infiltration, and attenuated astrocyte disfunction induced by CUS. CircDYM can bind mechanistically to the transcription factor TAF1 (TATA‐box binding protein associated factor 1), resulting in the decreased expression of its downstream target genes with consequently suppressed neuroinflammation. Taken together, our findings suggest that extracellular vesicle‐mediated delivery of circDYM is effective for MDD treatment and promising for clinical applications.
Experimental study of a physician‐controlled electrocautery‐enhanced delivery system incorporating a newly developed lumen‐apposing metal stent for interventional endoscopic ultrasound (with videos)
Authors: Mukai Shuntaro , Itoi Takao , Tsuchiya Takayoshi , Ishii Kentaro , Tanaka Reina , Tonozuka Ryosuke , Furuichi Yoshihiro , Joyama Eri , Miyazawa Hideaki , Sofuni Atsushi 
Published: January 2022

AbstractBackground/PurposeAlthough the lumen‐apposing metal stent (LAMS) is useful for interventional endoscopic ultrasound (EUS) procedures, there has been some concern about the potential for stent‐induced adverse events because of the high lumen‐apposing force. A newly designed LAMS with less lumen‐apposing force has been developed for use with a physician‐controlled electrocautery‐enhanced delivery system. The aim of this animal study was to evaluate the feasibility of performing interventional EUS using this newly designed LAMS system.MethodsEndoscopic ultrasound‐guided cystogastrostomy was performed using the novel LAMS three times in a wet simulation model. EUS‐guided gastroenterostomy and EUS‐guided gallbladder drainage were then performed using the system in four pigs.ResultsThe LAMS was successfully placed in all three EUS‐guided cystogastrostomy procedures using the wet simulation model and in all four EUS‐guided gastroenterostomy and gallbladder drainage procedures in the animal model. In the 3 weeks following the procedure, eating behavior was normal in all animals and there were no adverse events. The stents remained patent during this time and were removed without difficulty. The fistula was mature in all cases and a standard upper gastrointestinal endoscope was easily advanced via the fistula to observe the afferent and efferent loops or the lumen of the gallbladder. Necropsy confirmed complete adhesion between the stomach and the wall of the jejunum or gallbladder.ConclusionsOur study findings demonstrate the feasibility of this new LAMS system and its potential clinical value for interventional EUS.
Do not forget the children: a model‐based analysis on the potential impact of COVID‐19‐associated interruptions in paediatric HIV prevention and care
Authors: Flanagan Clare F. , McCann Nicole , Stover John , Freedberg Kenneth A. , Ciaranello Andrea L. 
Published: January 2022

AbstractIntroductionThe COVID‐19 pandemic has affected women and children globally, disrupting antiretroviral therapy (ART) services and exacerbating pre‐existing barriers to care for both pregnant women and paediatric populations.MethodsWe used the Spectrum modelling package and the CEPAC‐Pediatric model to project the impact of COVID‐19‐associated care disruptions on three key populations in the 21 Global Plan priority countries in sub‐Saharan Africa: (1) pregnant and breastfeeding women living with HIV and their children, (2) all children (aged 0–14 years) living with HIV (CLWH), regardless of their engagement in care and (3) CLWH who were engaged in care and on ART prior to the start of the pandemic. We projected clinical outcomes over the 12‐month period of 1 March 2020 to 1 March 2021.ResultsCompared to a scenario with no care disruption, in a 3‐month lockdown with complete service disruption, followed by 3 additional months of partial (50%) service disruption, a projected 755,400 women would have received PMTCT care (a 21% decrease), 187,800 new paediatric HIV infections would have occurred (a 77% increase) and 516,800 children would have received ART (a 35% decrease). For children on ART as of March 2020, we projected 507,200 would have experienced ART failure (an 80% increase). Additionally, a projected 88,400 AIDS‐related deaths would have occurred (a 27% increase) between March 2020 and March 2021, with 51,700 of those deaths occurring among children engaged in care as of March 2020 (a 54% increase).ConclusionsWhile efforts will continue to curb morbidity and mortality stemming directly from COVID‐19 itself, it is critical that providers also consider the immediate and indirect harms of this pandemic, particularly among vulnerable populations. Well‐informed, timely action is critical to meet the health needs of pregnant women and children if the global community is to maintain momentum towards an AIDS‐free generation.
Does conservation tillage on partially reclaimed sodic soil restore land degradation by influencing boron dynamics, bioavailability for plant's uptake and nutritional security?
Authors: Jha Sunil Kumar , Mishra Vinay Kumar , Damodaran Thukkaram , Singh Atul Kumar , Singh Yash Pal , Sharma Dinesh Kumar 
Published: January 2022

AbstractBoron (B) is nutritionally important for plants, humans and animals but its deficiency in soil and plants has become a global problem and may affect the nutritional quality of food. The widespread crop residue (CR) burning on farms is another environmental and land degradation problem, causing ecological threats to agriculture. Addressing these issues, a field experiment was initiated for B restoration by incorporating CR into partially reclaimed sodic soil under conservation tillage (zero or reduced tillage) and the results were compared with conventional tillage practices. We studied extensively the B‐dynamics, bioavailability, interaction with soil properties, uptake in rice and wheat, and plausible contribution in human dietary intake, upon consumption of rice and wheat. Results indicated that zero tillage and CR retention on the soil surface had a significant impact on soil B fractions. The readily soluble B, organically bound B varied from 0.1% to 2% and 11.8% to 39.4% of total B, respectively, and hot water extractable B was found highest in zero tillage. Readily soluble B had significant (p < 0.05) negative correlation with pH (r = −0.54), clay (r = −0.64), and CaCO3(r = −0.54). The highest B uptake was noticed in rice under zero tillage, where CR was retained on the soil surface. Dietary intake of B was assessed in terms of estimated daily intake, which was maximum in heavy activity men (0.0166 mg kg−1 d−1), conform to 0.02 mg kg−1 d−1, as prescribed by the World Health Organization. Thus, the study suggested that conservation tillage may be instrumental in the restoration of land degradation by building B in soil and contributes to nutritional security.
Graft Fibrosis Over 10 to 15 Years in Pediatric Liver Transplant Recipients: Multicenter Study of Paired, Longitudinal Surveillance Biopsies
Authors: Perito Emily R. , Persyn Elodie , Bucuvalas John , Martinez Mercedes , Mohammad Saeed , Squires James E. , Demetris Anthony J. , Feng Sandy 
Published: January 2022

Previous single‐center, cross‐sectional studies have reported a steep increase in the prevalence and severity of fibrosis through 10 to 15 years after pediatric liver transplantation. We report a multicenter study of paired surveillance biopsies in a contemporary cohort. Children who underwent liver transplant when younger than 6 years old and had paired surveillance liver biopsies were enrolled (n = 78, 35% girls, median 1.2 years old at transplant). A central pathologist graded inflammation, assessed rejection activity index, and staged fibrosis in the portal, sinusoidal, and perivenular compartments, allowing for calculation of the Liver Allograft Fibrosis Score (LAFSc). Analysis of variance tested associations between fibrosis progression and clinical parameters. The first biopsy, at a median 8.2 years (interquartile range, 5.9‐11.6 years) after transplantation, showed absent to mild fibrosis (LAFSc 0‐2) in 29%, moderate (LAFSc 3‐5) in 56%, and severe (LAFSc 6‐7) in 14% of patients. The second biopsy, at a median 4.7 years (IQR, 4.3‐5.1 years) later, showed fibrosis progression (LAFSc increased by ≥3) in 10 (13%) and regression (LAFSc decreased by ≥3) in 4 (5%) patients. After adjusting for baseline LAFSc, younger age at transplant was the only risk factor for fibrosis progression. Although fibrosis prevalence and severity 6 to 12 years after transplant was similar to previous reports, fibrosis trajectory during the next 4 to 5 years was stable. Our data may be reassuring for children with consistently normal liver tests. A comprehensive understanding of factors determining allograft health during the very long term is essential to optimizing allograft and patient health.
Chondroitin and Dermatan Sulfate Bioinks for 3D Bioprinting and Cartilage Regeneration
Authors: Lafuente‐Merchan Markel , Ruiz‐Alonso Sandra , Zabala Alaitz , Gálvez‐Martín Patricia , Marchal Juan Antonio , Vázquez‐Lasa Blanca , Gallego Idoia , Saenz‐del‐Burgo Laura , Pedraz Jose Luis 
Published: January 2022

AbstractCartilage is a connective tissue which a limited capacity for healing and repairing. In this context, osteoarthritis (OA) disease may be developed with high prevalence in which the use of scaffolds may be a promising treatment. In addition, three‐dimensional (3D) bioprinting has become an emerging additive manufacturing technology because of its rapid prototyping capacity and the possibility of creating complex structures. This study is focused on the development of nanocellulose‐alginate (NC‐Alg) based bioinks for 3D bioprinting for cartilage regeneration to which it is added chondroitin sulfate (CS) and dermatan sulfate (DS). First, rheological properties are evaluated. Then, sterilization effect, biocompatibility, and printability on developed NC‐Alg‐CS and NC‐Alg‐DS inks are evaluated. Subsequently, printed scaffolds are characterized. Finally, NC‐Alg‐CS and NC‐Alg‐DS inks are loaded with murine D1‐MSCs‐EPO and cell viability and functionality, as well as the chondrogenic differentiation ability are assessed. Results show that the addition of both CS and DS to the NC‐Alg ink improves its characteristics in terms of rheology and cell viability and functionality. Moreover, differentiation to cartilage is promoted on NC‐Alg‐CS and NC‐Alg‐DS scaffolds. Therefore, the utilization of MSCs containing NC‐Alg‐CS and NC‐Alg‐DS scaffolds may become a feasible tissue engineering approach for cartilage regeneration.
Fabrication of Antibacterial, Osteo‐Inductor 3D Printed Aerogel‐Based Scaffolds by Incorporation of Drug Laden Hollow Mesoporous Silica Microparticles into the Self‐Assembled Silk Fibroin Biopolymer
Authors: Ng Philipp , Pinho Ana Rita , Gomes Maria C. , Demidov Yan , Krakor Eva , Grume Daniela , Herb Marc , Lê Khan , Mano João , Mathur Sanjay , Maleki Hajar 
Published: January 2022

AbstractIn this study, the novel biomimetic aerogel‐based composite scaffolds through a synergistic combination of wet chemical synthesis and advanced engineering approaches have successfully designed. To this aim, initially the photo‐crosslinkable methacrylated silk fibroin (SF‐MA) biopolymer and methacrylated hollow mesoporous silica microcapsules (HMSC‐MA) as the main constituents of the novel composite aerogels were synthesized. Afterward, by incorporation of drug‐loaded HMSC‐MA into the self‐assembled SF‐MA, printable gel‐based composite inks are developed. By exploiting micro‐extrusion‐based three‐dimensional (3D) printing, SF‐MA‐HMSC composite gels are printed by careful controlling their viscosity to provide a means to control the shape fidelity of the resulted printed gel constructs. The developed scaffold has shown a multitude of interesting biophysical and biological performances. Namely, thanks to the photo‐crosslinking of the gel components during the 3D printing, the scaffolds become mechanically more stable than the pristine SF scaffolds. Also, freeze‐casting the printed constructs generates further interconnectivity in the printed pore struts resulting in the scaffolds with hierarchically organized porosities necessary for cell infiltration and growth. Importantly, HMSC incorporated scaffolds promote antibacterial drug delivery, cellular ingrowth and proliferation, promoting osteoblastic differentiation by inducing the expression of osteogenic markers and matrix mineralization. Finally, the osteoconductive, ‐inductive, and anti‐infective composite aerogels are expected to act as excellent bone implanting materials with an extra feature of local and sustained release of drug for efficient therapy of bone‐related diseases.
Quaternized Branched Polyethyleneimine Modified Nitrogen‐Doped Graphene Quantum Dots/Quaternized Polysulfone Composite Anion Exchange Membranes with Improved Performance
Authors: Dong Dawei , Zhang Minghua , Xiao Yafei , Yang Zhaojie , Wang Ke , Fan Minmin 
Published: January 2022

AbstractAnion exchange membrane (AEM) is essential for the development of alkaline anion exchange membrane fuel cells, and its performance largely depends on its internal microstructure. Herein, to improve the performance of AEM, quaternized branched polyethyleneimine modified nitrogen‐doped graphene quantum dots (QBPEI@N‐GQDs) are introduced to quaternized polysulfone (QPSU) polymer matrix to prepare a series of QPSU/QBPEI@N‐GQDs (QQ‐n‐N‐GQDs) composite AEMs. Due to the uniform distribution of hydrophilic QBPEI@N‐GQDs, an obvious hydrophilic/hydrophobic microphase separation structure is formed inside the QQ‐n‐N‐GQDs composite AEMs. Compared with the pristine QPSU AEM, the QQ‐0.7%‐N‐GQDs AEM shows slightly higher water uptake (WU) and swelling ratio (SR), as well as much higher ionic conductivity (76.18 mS cm−1 at 80 °C for QQ‐0.7%‐N‐GQDs AEM versus 46.14 mS cm−1 at 80 °C for pristine QPSU AEM) and better maximum power density of single fuel cell (85.2 mW cm−2 for QQ‐0.7%‐N‐GQDs AEM versus 46.3 mW cm−2 for QPSU AEM). Moreover, the chemical stability of QQ‐n‐N‐GQDs composite AEMs has not been significantly adversely affected by the introduction of QBPEI@N‐GQDs.