bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Resettable and Reprogrammable 3‐Input/3‐Output Biomolecular Keypad Lock Based on Stimulus‐Responsive Enzymatically Imprinted Polymer Film Electrodes
Authors: Lian Wenjing , Cui Chengxing , Lin Junyi , Wang Menghan , Liu Hongyun 
Published: January 2025

AbstractA complex biomolecular logic system based on stimulus‐responsive enzymatically imprinted polymer is constructed for the first time. Glucose oxidase (GOD) is served as the template to construct the molecularly imprinted polymer (MIP) with N‐isopropylacrylamide (NiPAAm) as the thermo‐sensitive monomer. The prepared MIP film electrodes demonstrate reversible GOD‐, temperature‐, and glucose‐sensitive on‐off electrochemiluminescence (ECL) behaviors toward luminol. Moreover, the addition of ferrocenedicarboxylic acid (Fc(COOH)2) into the luminol solution can enhance the ECL signal of the system and produce cyclic voltametric (CV) signals at GOD‐free MIP film electrodes. Based on these experiments, a 4‐input/5‐output biomolecular logic gate is established with GOD, temperature, glucose and Fc(COOH)2 as inputs and the simultaneous ECL and CV responses as outputs. On the same platform, some functional non‐Boolean logic devices such as encoder, decoder and demultiplexer are also constructed. In particular, a 3‐input/3‐output biomolecular keypad lock with resettability and reprogrammability is built based on this enzymatically imprinted polymer film electrodes for the first time. This work may provide a new avenue to realize more complex and efficient enzymatic logic calculation with a simple platform, and can further expand this system in biomolecular recognition and bioinformation storage.
RTN4IP1 Contributes to ESCC via Regulation of Amino Acid Transporters
Authors: Wei Huifang , Zhao Dengyun , Zhi Yafei , Wu Qiong , Ma Jing , Xu Jialuo , Liu Tingting , Zhang Jing , Wang Penglei , Hu Yamei , He Xinyu , Guo Fangqin , Jiang Ming , Zhang Dandan , Nie Wenna , Yang Ran , Zhao Tongjin , Dong Zigang , Liu Kangdong 
Published: January 2025

AbstractEsophageal squamous cell carcinoma (ESCC) accounts for about 90% of esophageal cancer cases. The lack of effective therapeutic targets makes it difficult to improve the overall survival of patients with ESCC. Reticulon 4 Interacting Protein 1 (RTN4IP1) is a novel mitochondrial oxidoreductase. Here, a notable upregulation of RTN4IP1 is demonstrated, which is associated with poor survival in patients with ESCC. RTN4IP1 depletion impairs cell proliferation and induces apoptosis of ESCC cells. Furthermore, c‐Myc regulates RTN4IP1 expression via iron regulatory protein 2 (IRP2) at the post‐transcriptional level. Mechanistically, RTN4IP1 mRNA harbors functional iron‐responsive elements (IREs) in the 3′ UTR, which can be targeted by IRP2, resulting in increased mRNA stability. Finally, RTN4IP1 depletion abrogates amino acid uptake and induces amino acid starvation via downregulation of the amino acid transporters SLC1A5, SLC3A2, and SLC7A5, indicating a possible pathway through which RTN4IP1 contributes to ESCC carcinogenesis and progression. In vivo studies using cell‐derived xenograft and patient‐derived xenograft mouse models as well as a 4‐nitroquinoline 1‐oxide‐induced ESCC model in esophageal‐specific Rtn4ip1 knockout mice demonstrate the essential role of RTN4IP1 in ESCC development. Thus, RTN4IP1 emerges as a key cancer‐promoting protein in ESCC, suggesting therapeutic RTN4IP1 suppression as a promising strategy for ESCC treatment.
Atrazine sensitivity varies among soybean cultivars
Authors: Ramanathan Shwetha S. , Gannon Travis W. , Everman Wesley J. , Locke Anna M. 
Published: January 2025

AbstractAtrazine carryover from application to a monocot crop may adversely affect soybean (Glycine max (L.) Merr.) grown in rotation. Here, we tested the hypothesis that genotype selection could reduce atrazine carryover damage to soybean. Five commercially relevant soybean varieties were evaluated for differences in sensitivity to a range of atrazine rates using visual ratings, photosynthetic, and biomass parameters. Visual injury ratings and photosynthetic gas exchange, chlorophyll fluorescence, relative chlorophyll content (SPAD), and aboveground biomass were measured during vegetative stages. Under 9.0 g a.i. ha−1 atrazine, SH 5515 LL exhibited visual injury and aboveground fresh biomass reduction but was unaffected in net photosynthesis rate (A) and effective quantum yield of photosystem II (ϕPSII) compared to controls. By 21 days after emergence (DAE), P53A67X recovered in A and ϕPSII, and AG56X8 recovered in SPAD. S52RS86 remained unaffected visually and photosynthetically at this atrazine rate. All genotypes treated with 179.2 g a.i. ha−1 atrazine showed higher injury ratings and lower SPAD, A, and ϕPSII after 7 DAE and lower aboveground biomass 21 DAE except S52RS86, which was similar in SPAD throughout. Atrazine at 358.4 and 716.8 g a.i. ha−1 caused plant death in all genotypes 14 DAE. Visual ratings were strongly correlated with photosynthetic measurements and aboveground biomass at each sampling. Soybean atrazine sensitivity is a function of atrazine concentration in the soil and genotype‐specific tolerance or recovery ability, indicating that growers can select soybean genotypes that reduce risk when atrazine carryover is suspected.
Limited Benefit of Routine Clinical Follow‐Up for Relapse Detection in Diffuse Large B‐Cell Lymphoma Patients in Complete Remission Following First‐Line Treatment
Authors: Lassen Therese , Nielsen Torsten H. , von Heymann Annika , Nielsen Lene K. , Larsen Morten K. , Gang Anne O. , Johansen Christoffer , Pedersen Lars M. 
Published: January 2025

ABSTRACTDespite advances in treatment, approximately 15% of patients with diffuse large B‐cell lymphoma (DLBCL) who achieve complete remission (CR) after first‐line therapy will experience a relapse. However, there is no consensus on the optimal follow‐up strategies for detecting relapse after achieving CR. This population‐based study, based on the Danish Lymphoma Registry (LYFO), identified a total of 1634 patients diagnosed with DLBCL between 2010 and 2017, including 105 patients who achieved CR following first‐line R‐CHOP‐like therapy and subsequently relapsed. The median follow‐up time was 6 years (range 3–8 years). Most cases of relapse were symptomatic (83%), with B symptoms and peripheral lymphadenopathy being the most common. Asymptomatic relapses were identified through physical examination (1%), blood tests (3%), or imaging findings (13%). The proportion of relapses identified outside routine visits was 70%. Only 5% of scheduled routine visits led to a relapse diagnosis, whereas 74% of unscheduled visits initiated by the patient outside routine follow‐up resulted in relapse detection. Our findings highlight that systematic, scheduled monitoring of patients in remission after first‐line treatment contributes only modestly to the early detection of disease recurrence. Future studies should explore alternative methods of relapse surveillance rather than relying solely on pre‐scheduled clinical follow‐up.
Orthorhombic Covalent Organic Frameworks with fmj Topology as Photocatalyst for Hydrogen Evolution
Authors: Wang Wen‐Zhuang , Tian Peng‐Ju , Fu Yubin , Wan Xiaolong , Lei Xiaoling , Jia Chao , Liu Chao , Qi Qiao‐Yan , Xu Shun‐Qi , Zhao Xin 
Published: January 2025

AbstractThree‐dimensional covalent organic frameworks (3D COFs), a class of highly porous crystalline polymers, have exhibited great potentials in many applications. However, the reported topologies of 3D COFs have been limited to high‐symmetry crystal systems, which significantly hindered the development of such functional materials. Herein, we demonstrate the first construction of four highly crystalline orthorhombic 3D COFs with an unprecedented fmj topology, based on judiciously choosing rotatable monomers. Notably, the square monomers in the unit cell of the fmj topological network adopt three different conformations, resulting in a highly complicated 3D network. Moreover, an isomeric pair (3DCOF‐CN and 3DCOF‐NC), differing only in the orientations of −C=N‐bonds, exhibit distinct optoelectronic properties, protonation abilities, and photocatalytic activities, which is the first time to reveal such isomeric effects in 3D COFs. Particularly, a difference of 32‐fold in photocatalytic hydrogen evolution rate was observed for the two isomers, with one achieving a superb rate up to ~31.1 mmol h−1 g−1. This work achieves the first construction of complex orthorhombic 3D COFs, and offers new insights for the development of 3D COF‐based high‐performance photocatalysts.
Reductive Carbon Materials: Tailoring Chemistry and Electronic Properties to Improve Sodium‐Ion Batteries
Authors: Begüm Yılmaz Elif , Oğuzhan Eren Enis , Horner Tim , Song Zihan , Sheidaei Yasaman , Siewert Inke , Senokos Evgeny , Giusto Paolo 
Published: January 2025

AbstractThe development of versatile strategies for preparing functional carbon materials is essential for advancing a wide range of applications in materials science. Precursor design plays a pivotal role in governing the chemistry and structure of carbon materials for target applications. In this work, we report the synthesis of Meldrum's acid derivatives through Knoevenagel condensation with aromatic heterocycles such as pyrrole, furan, and thiophene, which serve as precursors for carbonaceous materials with tailored chemical and electronic properties. The thermal condensation of these precursors proceeds via highly reactive, electron‐rich ketene intermediates, playing a crucial role in the formation of the carbon materials. The resulting heteroatom‐doped carbon materials exhibit tunable chemical, physico‐chemical, and structural properties, which we have correlated with their energy storage performances. Eventually, we deem this strategy of high interest for designing high‐performance carbonaceous materials with tunable properties for a broad range of applications, from electrochemical energy storage to conversion, water filtration, environmental remediation, and beyond.
Chitosan/Graphene Oxide/Ag Nanocomposites Loaded in Polyvinyl Alcohol Films as Biodegradable, UV‐Blocking, and Antibacterial Film for Fruit Packaging
Authors: Tran Nhung Thi , Nguyen Giang Tien , Le Tam Minh , Huynh Anh Tuan Nguyen 
Published: January 2025

ABSTRACTThe polyvinyl alcohol/chitosan/graphene oxide/Ag composite films are facilely fabricated as active multifunctional food packaging materials. The AgNPs of less than 10 nm immobilized onto CS/GO matrices are in situ synthesized by using NaBH4 as a reductant. The effect of different amounts of Ag and CS:GO weight ratios on the mechanical properties, water resistance, optical properties, thermal stability, and antibacterial activities of various films are systematically investigated. The composite film obtained at 0.5 wt% AgNP loading and a CS:GO ratio of 5:1 demonstrates significantly improved tensile strength (33.07 MPa, 1.7 times higher), reduced water swelling (2.4 times lower), increased contact angle (71.08° vs. 53.54°), and enhanced thermal stability compared to the neat PVA film. Additionally, these composite films exhibit excellent bacterial killing and inhibition activities against
Escherichia coli
and
Staphylococcus aureus
, with zones of inhibition of 10.09 nm and 12.66 mm, respectively. Interestingly, no viable bacteria were found with the film‐forming dispersion at 10 μg/mL. Furthermore, the fabricated films exhibit excellent UV‐blocking effects, sufficiently protecting exposed green plums from UV damage for 10 days. The membrane‐packed acerola fruits also demonstrate better freshness, slower ripening rate, and no signs of microbial growth as compared to those packed with commercial polyethylene film.
Diagnostic Performance and Safety of Ultrasound‐Guided Core Needle Biopsy for Diagnosing Lymphoma: A Systematic Review and Meta‐Analysis
Authors: Kwon Yongmin , Lee Min Kyoung 
Published: January 2025

ABSTRACTBackgroundLymphoma arises from transformed lymphoid cells. Although surgical excision biopsy is the standard diagnostic tool for patients with lymphoma, image‐guided fine‐needle aspiration (FNA) or core needle biopsy (CNB) is considered an alternative diagnostic option.ObjectiveTo assess the diagnostic accuracy and safety of ultrasound (US)‐guided core needle biopsy (CNB) in patients with lymphoma.MethodsA systematic review and meta‐analysis were conducted. A literature search was performed up to January 1, 2024, using the Ovid‐MELIBE and EMBASE databases to identify studies focusing on US‐guided CNB in lymphoma patients. Relevant outcomes, including sensitivity, specificity, and complication rates, were extracted from the included studies. The Der‐Simonian‐Laird random‐effects model was applied to analyze the pooled data.ResultsThe pooled sensitivity of US‐guided CNB in lymphoma patients was 94% (95% CI = 89%–96%), and the specificity was 100% (95% CI = 94%–100%). The pooled complication rate was 1% (95% CI = 0%–3%), with self‐limiting complications being the most common.ConclusionUS‐guided CNB demonstrated high diagnostic accuracy and low complication rates in patients with lymphoma, supporting its use as an alternative diagnostic tool.
Getting Better, Together: An Integrated, Online Group Psychotherapy Programme for Mental and Physical Health
Authors: Lang Brent , Williams Kara , Wiblishauser Michael , Adcock Steal 
Published: January 2025

ABSTRACTBackgroundSocial distancing during the COVID‐19 pandemic was associated with increases in sedentary behaviours, alcohol and illicit substance use and weight gain. Early lockdowns and mandated social distancing also led to increases in symptoms of anxiety, depression and other mental health symptoms. During the pandemic, a major shift in healthcare service delivery to telehealth occurred and group psychotherapy delivered online was effective in decreasing mental health symptoms and loneliness.ObjectiveThe overall goal of this study was to assess the initial effectiveness of an eight‐session, comprehensive group psychotherapy programme delivered online to improve mental and physical health for adults who were impacted by the COVID‐19 pandemic. This pilot programme promoted physical activity, nutrition, behavioural health and overall healthy living.MethodAfter creating our eight‐session, multidisciplinary programme, we partnered with the local health department, community mental health centre and local media to recruit N = 53 community members from southern Texas, USA. We thoroughly screened participants using a structured clinical interview and standardised assessments. A total of n = 50 were eligible and placed into groups based on availability and n = 41 completed all sessions. Most participants were female and between the ages of 18 and 40 years, and of Caucasian or Hispanic descent. The sample included both those who met criteria for a mental health diagnosis and those who did not. Groups, on average, had 5–7 participants and began in August 2020 and ended in February 2021. Future clinicians and researchers may wish to use or adapt the treatment programme (including the treatment manual) from this study to guide future research or clinical efforts.ResultsCompared to baseline, participants reported significant reductions in anxiety and loneliness and improved satisfaction in their level of participation in social activities. Participants reported enjoying the socialisation of the group format.ConclusionsOur pilot programme demonstrated initial evidence supporting effectiveness of a multidisciplinary, biopsychosocial group delivered online to improve mental health outcomes. Future randomised controlled trials are needed to establish efficacy and inform potential, broader implementation of the programme.Public Significance StatementThis study found that an integrated, group psychotherapy programme based on acceptance and commitment therapy, motivational interviewing and interpersonal psychotherapy was effective in reducing anxiety and loneliness during the COVID‐19 pandemic. The online delivery of this programme makes it especially useful in reaching socially isolated adults, such as those in rural settings.
Glucuronoxylomannan (GXM) modulates macrophage proliferation and apoptosis through the STAT1 signaling pathway
Authors: Huang Youming , Li Sujing , Teng Yan , Ding Xiaoxia , Xu Danfeng , Yang Xianhong , Yu Yong , Fan Yibin 
Published: January 2025

Abstractcryptococcus neoformans (C. neoformans) is a crucial opportunistic fungus that possesses an encapsulated fungal pathogen. The cryptococcal capsule is mainly composed of the polysaccharide glucuronoxylomannan (GXM). Macrophages form the first‐line innate defense against cryptococcosis; however, the underlying mechanism remains unclear. In this study, GXM‐treated RAW264.7 macrophages showed a notably reduced survival rate and increased apoptosis, accompanied by the promoted inducible nitric oxide synthase (iNOS) expression and NO production. Signal transducer and activator of transcription 1 (STAT1) expression was also found to be directly proportional to GXM concentration; STAT1 knockdown could alleviate GXM‐induced proliferation decrease and apoptosis increase of macrophages, as well as reduce M1 polarization, iNOS expression and NO release. In conclusion, this study concluded that GXM was the main virulence factor of C. neoformans, which is critical in determining the mechanism of GXM‐mediated protective immune response postinfection. The STAT1 signal pathway mediates the effect of GXM stimulation on macrophages, potentially providing a reference for further understanding the biological role of GXM.
Catheterization Techniques for Anomalous Aortic Origin of Coronary Arteries
Authors: Fretay Xavier Halna du , Boudvillain Olivier , Koutsoukis Athanasios , Degrell Philippe , Dupouy Patrick , Aubry Pierre 
Published: January 2025

ABSTRACTAnomalous aortic origin of a coronary artery (AAOCA) is a rare congenital anomaly with a large spectrum of anatomical variations. Selective engagement of an AAOCA can present challenges during cardiac catheterization. A comprehensive understanding of the characteristics of major AAOCA can effectively assist operators for selecting and maneuvering catheters. This review outlines the recommended catheter manipulations based on the site of ectopic coronary origin. Identifying the initial course (prepulmonic, subpulmonic, interarterial or retroaortic course) is crucial for classifying each AAOCA. Besides invasive coronary angiography, coronary computed tomography angiography is frequently utilized to enhance the diagnostic assessment. Cardiac catheterization enables the use of intracoronary imaging and physiologic tools for accurately assessing the significance of AAOCA identified as at risk, mainly the anomalies associated with an interarterial course. Intravascular ultrasound is recognized as the gold standard for analyzing AAOCA with interarterial course. Optical tomography coherence imaging can be interesting to evaluate the rare AAOCA with a subpulmonic course, which are associated with ischemic symptoms or myocardial ischemia. Invasive physiological indices using pressure wires can be employed, with the caveat that their threshold values remain uncertain. Decision‐making can be challenging for patients with AAOCA. Both non‐invasive and invasive imaging tools are essential to support the final choice.
High Performance Sodium‐Ion Hybrid Capacitor Based on Graphene‐Tin Pyrophosphate Nanocomposite Anode
Authors: Moreno‐Fernández Gelines , Granados‐Moreno Miguel , Carriazo Daniel 
Published: January 2025

AbstractThe development of alternative energy storage technologies such as sodium‐ion hybrid capacitors, which do not rely on critical raw materials such as cobalt or nickel, for the replacement of conventional lithium‐ion batteries for some niche applications, is extremely important to successfully achieve a sustainable development in our planet. In this work, we introduce a novel sodium‐ion hybrid capacitor system formed by the combination of an optimized nanostructured composite material containing reduced graphene oxide and tin pyrophosphate as negative electrode, and a high specific surface area graphene‐carbon composite as positive electrode. The electrochemical performance of each material has been individually evaluated using NaPF6 in EC/DMC as electrolyte, showing impressive specific capacity values above 100 mAh g−1 at 2 A g−1, for both faradaic and capacitive‐type electrodes. The integration of the electrodes in an optimized full cell with anode‐to‐cathode mass balance of 1.5 : 1, enabled stable full cells that can provide energy densities of almost 60 Wh kg−1 at 3,000 W kg−1, showcasing the potential of these type of materials in the design of next generation energy storage systems.
Inorganic Solid‐State Electrolytes for Solid‐State Sodium Batteries: Electrolyte Design and Interfacial Challenges
Authors: Lee Dongsoo , Kumar Kakarla Ashok , Sun Seho , Joohyun Kim Patrick , Choi Junghyun 
Published: January 2025

AbstractRecent advancements in inorganic solid electrolytes (ISEs), achieving sodium (Na)‐ion conductivities exceeding 10 ‐2 S cm‐1 at room temperature (RT), have generated significant interest in the development of solid‐state sodium batteries (SSSBs). However, the ISEs face challenges such as their limited electrochemical stability windows (ESWs) and compatibility issues with high‐capacity, high‐voltage cathode materials and Na metal anodes. The success of high‐performance SSSBs hinges on developing ideal ISEs that deliver high Na+ ion conductivities, robust chemical and electrochemical stability, and well constructed electrode/ISE interfaces. This review explores the fundamental principles and strategies to optimize SSSB performance by addressing issues related to ISEs and their interfaces, emphasizing that many interfacial challenges are intrinsically linked to ISE properties. It highlights recent advancements in ISE research, including the mechanisms of Na‐ion conduction and the key factors influencing it, such as crystal structure, lattice dynamics, point defects, and grain boundaries. It also discusses prototyping strategies for cell design from the perspectives of material and defect chemistry. Additionally, the review identifies key challenges and future opportunities for advancing SSSBs and provides rational solutions to guide future research toward the practical realization of high‐performance SSSBs.Keywords: Solid‐state sodium batteries; Inorganic solid electrolytes; Interfacial mechanism; Electrochemical stability window; Ionic conductivity; Modification strategies
Quinizarin Gold(I) N‐Heterocyclic Carbene Complexes with Synergistic Activity Against Anthracycline‐Resistant Leukaemia Cells: Synthesis and Biological Activity Studies
Authors: Steinbrueck Axel , Reback Matthew L. , Rumancev Christoph , Siegmund Daniel , Garrevoet Jan , Falkenberg Gerald , Rosenhahn Axel , Prokop Aram , Metzler‐Nolte Nils 
Published: January 2025

AbstractNew, asymmetric quinizarin‐Au(I)‐NHC complexes were designed, isolated, and fully characterised including by single crystal X‐ray crystallography. Cytotoxicity studies showed effective growth inhibition in HeLa cervical cancer cells with IC50 values ranging from 2.4 μM to 5.3 μM. The successful cellular uptake was evidenced by X‐ray fluorescence imaging on cryo‐preserved whole HeLa cells and the sub‐cellular localisation was monitored by live‐cell fluorescence microscopy. Notably, complex 2 b showed circumvention of acquired anthracycline resistance in K562 leukaemia cells as well as synergistic activity with doxorubicin against both wild‐type and anthracycline‐resistant Nalm‐6 leukaemia cells. Interestingly, sub‐cellular localisation towards mitochondria proved to be more important than the compounds’ overall cytotoxicity for potent antiproliferative activity and to achieve effective resistance circumvention.