bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cumarin und Antikoagulanzien
Authors: Wiebrecht Axel 
Published: March 2022

Leserbrief zum Artikel Abendroth A et al. 2021
Sehr geehrte Herausgeber,vielen Dank an die Autoren für den interessanten Artikel zu Interaktionen von
Phytotherapeutika mit den direkten oralen Antikoagulanzien (DOAK) 1. DOAK gelten allgemein als wenig
interaktionsanfällig, und es gibt bisher wenige Berichte über
klinische Fälle von Interaktionen mit ihnen, insbesondere was pflanzliche
Arzneimittel anbelangt. Wie der im Artikel geschilderte zweite Fall 2 zeigt, können unerwünschte
Arzneimittelreaktionen mit Blutungen sehr schnell einen dramatischen und sogar
fatalen Verlauf annehmen.
Current Insights into Cellular Senescence and Myotoxicity Induced by
Doxorubicin: The Role of Exercise and Growth Factors
Authors: Andreou Charalampos , Matsakas Antonios 
Published: March 2022

AbstractDoxorubicin is an anti-neoplasmic drug that prevents DNA replication but induces
senescence and cellular toxicity. Intensive research has focused on strategies
to alleviate the doxorubicin-induced skeletal myotoxicity. The aim of the
present review is to critically discuss the relevant scientific evidence about
the role of exercise and growth factor administration and offer novel insights
about newly developed-tools to combat the adverse drug reactions of doxorubicin
treatment on skeletal muscle. In the first part, we discuss current data and
mechanistic details on the impact of doxorubicin on skeletal myotoxicity. We
next review key aspects about the role of regular exercise and the impact of
growth factors, administered either pharmacologically or via genetic
interventions. Future strategies such as combination of exercise and growth
factor administration remain to be established to combat the
pharmacologically-induced myotoxicity.
Effects of Peri-Conception and Pregnancy Glycemic Variability on
Pregnancy and Perinatal Complications in Type 1 Diabetes: A Pilot
Study
Authors: Hoek-Hogchem Riëlle , Bovenberg Sarah A. , Dekker Pim , Birnie Erwin , Veeze Henk J. , Duvekot Hans J. , Galjaard Sander , Aanstoot Henk-Jan 
Published: March 2022

Abstract
Background Not much is known about the effects of glycemic variability
(GV) during the pre- and periconception period on pregnancy/perinatal
complications. GV could potentially contribute to identification of high-risk
pregnancies in women with type 1 diabetes.
Methods An explorative retrospective cohort study was conducted between
January 2014 and May 2019. Glucose data were retrieved from electronic patient
charts. Pre-/periconceptional GV and GV during all three trimesters was
expressed as mean glucose, standard deviation (SD), Coefficient of Variation
(CV), High Blood Glucose Index (HBGI), Low Blood Glucose Index (LBGI) and
Average Daily Risk Range (ADRR). Maternal and neonatal complications were
summarized using a composite total complication score. Binary logistic
regression analyses were conducted to assess associations between the GV
measures and a total complication score>3, a maternal complication
score>1 and a neonatal complication score>1.
Results Of 63 eligible women, 29 women (38 pregnancies) were included.
Women in the group with a total complication score>3 had a significantly
higher ADRR at conception (OR 1.1, CI 1.0–1.2, p=0.048). No
statistically significant correlations between complication score and any other
GV metric besides the ADRR were found. Although not significant, in the group
with a complication score>3, odds ratios>1 were found for SD in
trimester 1 (OR 1.6, CI 0.6–4.5, p=0.357) and trimester 2 (OR
1.8, CI 0.5–6.2, p=0.376).
Conclusions Presence of a positive association between GV and pregnancy
and perinatal complications depends on which pregnancy period is assessed and
the GV metrics that are used.
Basal Ganglia Traumatic Hematoma: Case Series and Literature Review
Authors: Pereira Carlos Umberto , Kalkmann Gabriela Ferreira , Nascimento Isabela do Prado , Santos Letícia Adrielle dos , Rabelo Nicollas Nunes 
Published: March 2022

AbstractIntroduction Basal ganglia traumatic hematoma (BGTH) is rare, occurring in 3% of closed traumatic brain injuries, and it is associated with a poor prognosis. In the present paper, the authors present a series of 16 BGTH cases, describing their causes, treatment, and results.Patients and Methods Thisis a retrospective study of 16 patients diagnosed with BGTH, associated with a literature review in the PubMed, ScienceDirect, and Google Scholar databases, using the terms craniocerebral trauma AND basal ganglia and basal ganglia AND hematoma AND trauma. Articles published in the period from 1986 to 2019 were selected, resulting in a total of 19 articles that met the inclusion criteria taking into account their citations and their respective impacts.Results Sixteen patients were studied. They were all male, with an average age of 21 years and 5 months. The main cause of BGTH was traffic accident (12). The mean score in the Glasgow coma scale at admission was 8. All patients underwent a computed tomography (CT) scan of the skull. The putamen was the most affected structure (5). Thirteen patients underwent conservative treatment, and three drained the associated intracranial hematoma. Nine patients died, and seven, and four had neurological sequel.Conclusions The neurosurgeon's knowledge of GBTH, including diagnosis and clinical surgical management, is extremely important, as this type of lesion is associated with a poor prognosis.
Vaccine hesitancy and monetary incentives
Authors: Iyer Ganesh , Nandur Vivek , Soberman David 
Published: March 2022

AbstractVaccine hesitancy is a significant barrier to reaching herd immunity and exiting the Covid-19 pandemic. This study examines the potential effectiveness of monetary incentives in conjunction with informational treatments about vaccine efficacy, lack of side effects, and zero costs. We elicit monetary valuations (both positive and negative) for the coronavirus vaccine by conducting an online randomized experiment on a representative sample of 2461 individuals across the US. The study elicits vaccination uptake, then participants’ valuations (willingness to pay (WTP) or the willingness to accept (WTA)) for the vaccine based upon the stated choice of participants to accept or reject the vaccine. We find that a $1000 incentive increases vaccination uptake up to 86.9%. We identify two distinct segments among the vaccine hesitants—“Reluctants” and “Unwillings”. Reluctants can be persuaded to vaccinate for some level of monetary incentive, whereas Unwillings indicate that no amount of monetary incentive will persuade them to vaccinate. The Unwillings are more likely to (a) think that the disease is insufficiently severe, (b) have less faith in the public health system, (c) be older, compared to the Reluctants.
Impact of automation on long haul trucking operator-hours in the United States
Authors: Mohan Aniruddh , Vaishnav Parth 
Published: March 2022

AbstractAutomated long haul trucking is being developed for commercial deployment in the United States. One possible mode of deployment for this technology is a “transfer-hub” model where the operationally less complex highway driving is automated, while human drivers drive the more complex urban segment of the route. We study the possible net impacts on tractor-trailer operator-hours from this mode of deployment. Using data from the 2017 Commodity Flow Survey, we gather information on trucking shipments and the operator-hours required to fulfill those shipments. We find that up to 94% of long haul trucking operator-hours may be impacted as the technology improves to operate in all weather conditions. If the technology is however restricted to the southern states where the majority of companies are currently testing automated trucking, we find that only 10% of operator-hours are impacted. We conduct interviews with industry stakeholders including tractor-trailer operators on the feasibility of such a system of deployment. We find that an increase in short haul operation is unlikely to compensate for the loss in long haul operator-hours, despite public claims to this effect by the developers of the technology. Policymakers should consider the impact of different scenarios of deployment on the long haul trucking workforce.
Analysis and experimental research on high frequency magnetic properties of different magnetostrictive materials under variable temperature conditions
Authors: Huang Wenmei , Xia Zhiyu , Guo Pingping , Weng Ling 
Published: March 2022

Magnetostrictive materials have excellent magneto-mechanical properties and are widely used in the field of energy conversion. Temperature has an important influence on the magnetic properties of them. Accurately studying the temperature dependence of magnetostrictive materials is a necessary prerequisite for the design of precision actuators. In this paper, we constructed a high-frequency magnetic property measurement system that can control the temperature. The magnetic characteristics of Terfenol-D, Fe-Ga and Fe-Co were measured at temperatures ranging from 10 °C to 80 °C, the frequencies from 1 kHz to 20 kHz and magnetic induction amplitudes from 0.01 T to 0.07 T. The temperature dependence of the three materials under different exciting conditions was comprehensively compared. The variation trends and temperature sensitivities of the coercivity, permeability, equivalent inductance, equivalent resistance and the magnetic energy losses are analyzed respectively. The results of this paper are oriented to practical engineering applications and can be used for high-frequency loss prediction and temperature control system design.
The effect of high pressure on the electrical and transport properties of the InSb-MnSb magnetic eutectic composition
Authors: Kochura A. V. , Dzhamamedov R. G. , Mekhiya A. B. , Oveshnikov L. N. , Arslanov T. R. , Rodionov V. V. , Alam M. , Kuzmenko A. P. , Davydov A. B. , Aronzon B. A. 
Published: March 2022

In this work we studied transport properties of eutectic InSb-MnSb crystals with oriented MnSb needle-like inclusions under a hydrostatic pressure up to P = 8 GPa and after its application. We show that the pressure-induced variation of the samples resistivity and transport parameters at room temperature can be interpreted in the terms of crystal phase transition of the InSb matrix. We argue that the irreversibility of this transition, deduced from transport measurements, may stem from the composite nature of the crystals studied. The resistivity of the samples subjected to high pressures increases upon cooling, which can be a consequence of the increased disorder accompanying the irreversible transition. Magnetotransport data for these samples suggest that charge carriers interact with a low-temperature magnetic phase. The latter can be formed by isolated Mn atoms in the InSb matrix.
FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation
Authors: Yang Haibo , Wang Yumin , Xiang Yufei , Yadav Tribhuwan , Ouyang Jian , Phoon Laiyee , Zhu Xueping , Shi Yi , Zou Lee , Lan Li 
Published: March 2022

Significance
This study shows that Fragile X mental retardation protein (FMRP) promotes messenger RNA (mRNA)-dependent recombination via facilitating ten-eleven translocation protein 1 (TET1)-mediated mRNA methyl-5-cytosine (m5C) demethylation. Loss of FMRP leads to damage induced mRNA m5C and R-loop accumulation at sites of active transcription, defective recombination repair, and increased radiosensitivity of tumor cells. FMRP-dependent RNA m5C demethylation and R-loop resolving during DNA repair are important for repair completion and the maintenance of genome stability. The removal of m5C by the FMRP–TET1 axis is coupled with R-loop dissolution, which ensures proper completion of DNA repair and survival of cells after DNA damage. These findings significantly advance our understanding of the regulation of RNA modifications in R-loop dynamics during DNA repair.
Single-molecule fluorescence imaging and deep learning reveal highly heterogeneous aggregation of amyloid-β 42
Authors: Meng Fanjie , Yoo Janghyun , Chung Hoi Sung 
Published: March 2022

SignificanceThere are various diseases caused by protein aggregation such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. From the diversity in the fibril structure, aggregation is expected to occur via heterogeneous pathways. However, characterization of this heterogeneity is extremely difficult because it requires following individual fibril formation in a mixture from early oligomerization stages. In this work, we investigated aggregation of the 42-residue isoform of amyloid β (Aβ42) using single-molecule fluorescence imaging and deep learning. We could track the growth of individual fibrils, which allows for a quantitative description of heterogeneous fibril formation and discovery of a new fibril nucleation mechanism. Further characterization of heterogeneity involving Aβ42 will be important for better understanding the disease mechanism.
Syntheses of three-dimensional catenanes under kinetic control
Authors: Wu Yong , Guo Qing-Hui , Qiu Yunyan , Weber Jacob A. , Young Ryan M. , Bancroft Laura , Jiao Yang , Chen Hongliang , Song Bo , Liu Wenqi , Feng Yuanning , Zhao Xingang , Li Xuesong , Zhang Long , Chen Xiao-Yang , Li Hao , Wasielewski Michael R. , Stoddart J. Fraser 
Published: March 2022

Significance
During the past decades, the development of efficient methodologies for the creation of mechanically interlocked molecules (MIMs), such as catenanes and rotaxanes, has not only laid the foundation for the design and syntheses of artificial molecular machines (AMMs) but also opened up new research opportunities in multiple disciplines, ranging from contemporary chemistry to materials science. In this study, we describe a suitane-based strategy for the construction of three-dimensional (3D) catenanes, a subset of MIMs that are far from easy to make. Together with synthetic methodologies based on the metal coordination and dynamic covalent chemistry, this approach brings us one step closer to realizing routine syntheses of 3D catenanes.
Global genomic instability caused by reduced expression of DNA polymerase ε in yeast
Authors: Zhang Ke , Sui Yang , Li Wu-Long , Chen Gen , Wu Xue-Chang , Kokoska Robert J. , Petes Thomas D. , Zheng Dao-Qiong 
Published: March 2022

Significance
Although most studies of the genetic regulation of genome stability involve an analysis of mutations within the coding sequences of genes required for DNA replication or DNA repair, recent studies in yeast show that reduced levels of wild-type enzymes can also produce a mutator phenotype. By whole-genome sequencing and other methods, we find that reduced levels of the wild-type DNA polymerase ε in yeast greatly increase the rates of mitotic recombination, aneuploidy, and single-base mutations. The observed pattern of genome instability is different from those observed in yeast strains with reduced levels of the other replicative DNA polymerases, Pol α and Pol δ. These observations are relevant to our understanding of cancer and other diseases associated with genetic instability.
Nitrogen addition frequency and propagule pressure influence
Solidago canadensis
invasion into native plant community
Authors: Liu Xuan-Shao , Cai Jing-Fang , Liu Lin , Sun Kai , Jiang Fan , Shen Yi-Luan , A Si-Ha , Li Hong-Li 
Published: March 2022

ABSTRACT

Introduction
Propagule pressure (i.e., the number of propagules) has long been recognized to play an essential role in plant invasion. But it is not clear whether propagule pressure influences the invasion of exotic plants into native plant communities when different frequencies of nitrogen are added.

Method

We established an experiment with three plant communities that included native plant communities alone (four grasses, two legumes and two forbs) or native plant communities with one or five invasive plants,
Solidago canadensis
, under three frequencies of nitrogen addition (no addition or low or high addition with the same amount).

Results

High propagule pressure significantly enhanced the biomass and relative dominance index of
S. canadensis
. Moreover, high propagule pressure only decreased the total and aboveground biomass of the legumes. However, the competitive effect between
S. canadensis
and the native community and biomass of the whole native community varied according to different frequencies.

Conclusion

Overall, high propagule pressure encouraged invasion by
S. canadensis
, while alow nitrogen frequency was advantageous for the native community to resist invasion in this experiment. The results provide a scientific basis to manage and control the invasion of
S. canadensis
.
Investigation of the high-field transport, Joule-heating-driven conductivity improvement and low-field resistivity behaviour in lightly-reduced free-standing graphene oxide papers
Authors: Thamkrongart Krongtham , Ramamoorthy Harihara , Buapan Kanokwan , Chiawchan Tinna , Somphonsane Ratchanok 
Published: March 2022

AbstractFree-standing reduced graphene oxide (rGO) has been gaining popularity for its use in supercapacitors and battery applications due its facile synthesis, multi-layered structure, and high-current carrying capacity. Pertinent to the successful implementation of such applications, however, is the need to develop a thorough understanding of the electrical properties of such materials when subject to high applied electric fields. In this work, we undertake a detailed study of high-field electrical properties of mm-scale, lightly-reduced, rGO papers. Our results reveal that theI–Vcurves exhibit substantial nonlinearity with associated hysteresis that depends strongly on the applied electric field. The nonlinear behaviour which was interpreted using conventional transport models of Fowler–Nordheim tunnelling and space charge limited conduction revealed that while these models provided good qualitative fits to our data, they were quantitatively lacking, thus leaving the issue of high-field transport mechanisms in rGO open for debate. CarefulI–Vcycling experiments with measurement time-delay introduced between cycles revealed that the observed hysteresis contained recoverable and non-recoverable parts that we identified as arising from charge trapping and Joule heating effects, respectively. Time-dependent measurements showed that these effects were characterized by two distinct time scales. Importantly, the Joule heating was found to cause a permanent conductivity improvement in the rGO via the ‘current annealing’ effect by effectively eliminating oxygenated groups from the rGO. The analysis of the electrical breakdown in our samples resembled a thermal runaway-like event that resulted in premature damage to the rGO. Finally, we investigated the low-field resistivity in the 80 K–300 K temperature range. The reduced activation energy analysis revealed a robust power law behaviour below 230 K, while deviating from this trend at higher temperatures. For samples that received current annealing treatment, a reduced value for the power law exponent was obtained, confirming the effective lowering of disordered regions.
Enhanced perpendicular magnetic anisotropy of ferrimagnetic Mn4N films deposited on the glass substrate
Authors: Li Wenchang , Xu Xinxing , Gao Tenghua , Harumoto Takashi , Nakamura Yoshio , Shi Ji 
Published: March 2022

Abstract
Mn4N films have been prepared on the glass substrate by reactive magnetron sputtering, using Mn3N2 as the seed layer. Compared with Mn4N film directly grown on the glass substrate, the crystallinity and perpendicular magnetic anisotropy (PMA) of the Mn4N film with the seed layer are significantly enhanced. By varying the thickness of the Mn3N2 seed layer, the structural and magnetic properties are systematically investigated. It is shown that the seed layer thickness is pivotal in the growth of Mn4N with good crystallinity. The crystallinity of Mn4N first improves with the increase in the layer thickness of Mn3N2, and degrades after an optimal thickness; this is related to the change in the surface roughness of the Mn3N2 layers. The Mn3N2 layer not only promotes the growth of Mn4N film with c-axis orientation, but also provides additional N atoms to the growing surface to prevent Mn4N from being oxidized. This simple method can be used to prepare high-quality Mn4N films on a glass substrate, which show strong PMA and are suitable for spintronics applications.
Prediction and comparative analysis of CTCF binding sites based on a first principle approach
Authors: Oiwa Nestor Norio , Li Kunhe , Cordeiro Claudette E , Heermann Dieter W 
Published: March 2022

Abstract
We calculated the patterns for the CCCTC transcription factor (CTCF) binding sites across many genomes on a first principle approach. The validation of the first principle method was done on the human as well as on the mouse genome. The predicted human CTCF binding sites are consistent with the consensus sequence, ChIP-seq data for the K562 cell, nucleosome positions for IMR90 cell as well as the CTCF binding sites in the mouse HOXA gene. The analysis of Homo sapiens, Mus musculus, Sus scrofa, Capra hircus and Drosophila melanogaster whole genomes shows: binding sites are organized in cluster-like groups, where two consecutive sites obey a power-law with coefficient ranging from 0.3292 ± 0.0068 to 0.5409 ± 0.0064; the distance between these groups varies from 18.08 ± 0.52 kbp to 42.1 ± 2.0 kbp. The genome of Aedes aegypti does not show a power law, but 19.9% of binding sites are 144 ± 4 and 287 ± 5 bp distant of each other. We run negative tests, confirming the under-representation of CTCF binding sites in Caenorhabditis elegans, Plasmodium falciparum and Arabidopsis thaliana complete genomes.
The evolution of the solitons in periodic photonic moiré lattices controlled by rotation angle with saturable self-focusing nonlinearity media
Authors: Zhang Yingying , Qin Yali , Zheng Huan , Ren Hongliang 
Published: March 2022

Abstract
We explored the evolution and stability of solitons formed by a Gaussian beam excited on-site in periodic photonic moiré lattices controlled by an angle with saturable self-focusing nonlinearity medium of lower applied bias, which makes use of the square lattices as a reference. When we introduce the rotation angle

θ

(

θ
∈
(
0
,

π

/

2

)

), which satisfies the Pythagorean theorem and is commensurable, it will create a new lattice structure by rotating and superimposing two square lattices of the same period, which we called periodic photonic moiré lattices. Its energy band structure is special, which includes the flat band, and even opens the higher band-gap compared with square lattices. On the other hand, when we reduce the applied bias of the crystal, periodic photonic moiré lattices can still suppress the diffraction behaviour of Gaussian beam effectively and realize light localization by contrast with square lattices. Moreover, we proved the stability of the solitons formed by the Gaussian beams excited on-site in periodic photonic moiré lattices and revealed that the solitons could keep stable, but their stability regimes depend on the rotation angle shrinks and belong to the different bandgap. The discovery of the photonic moiré lattice provides a fresh approach for suppressing the diffraction behaviour of light and reduces the requirement for nonlinearity, which is beneficial for the diversity of our crystal material selection, and also provides a new way to manufacture high-efficiency optoelectronic devices.