bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy of lung and diaphragm ultrasound in predicting successful extubation in extremely preterm infants: A prospective observational study
Authors: Mohsen Nada , Nasef Nehad , Ghanem Mohab , Yeung Telford , Deekonda Veena , Ma Carmen , Kajal Dilkash , Baczynski Michelle , Jain Amish , Mohamed Adel 
Published: November 2022

AbstractObjectiveChest ultrasound has emerged as a promising tool in predicting extubation readiness in adults and children, yet its utility in preterm infants is lacking. Our aim was to assess the utility of lung ultrasound severity score (LUSS) and diaphragmatic function in predicting extubation readiness in extremely preterm infants.Study DesignIn this prospective cohort study, preterm infants < 28 weeks gestational age (GA) who received invasive mechanical ventilation for ≥12 h were enrolled. Chest ultrasound was performed before extubation. The primary outcome was lung ultrasound accuracy for predicting successful extubation at 3 days. Descriptive statistics and logistic regression were done using SPSS version 22.ResultsWe enrolled 45 infants, of whom 36 (80%) were successfully extubated. GA and postmenstrual age (PMA) at extubation were significantly higher in the successful group. The LUSS was significantly lower in the successful group compared to failed group (11.9 ± 3.2 vs. 19.1 ± 3.1 p < 0.001). The two groups had no statistically significant difference in diaphragmatic excursion or diaphragmatic thickness fraction. Logistic regression analysis controlling for GA and PMA at extubation showed LUSS was an independent predictor for successful extubation (odd ratio 0.46, 95% confidence interval [0.23–0.9], p = 0.02). The area under the receiver operating characteristic curve was 0.95 (p ˂ 0.001) for LUSS, and a cut‐off value of ≥15 had 95% sensitivity and 85% specificity in detecting extubation failure.ConclusionIn extremely preterm infants, lung ultrasound has good accuracy for predicting successful extubation. However, diaphragmatic measurements were not reliable predictors.
Leptosphaeria biglobosa inhibits the production of sirodesmin PL by L. maculans
Authors: Fortune James A. , Bingol Evren , Qi Aiming , Baker Daniel , Ritchie Faye , Karandeni Dewage Chinthani S. , Fitt Bruce D. L. , Huang Yong‐Ju 
Published: November 2022

AbstractBACKGROUNDPhoma stem canker is caused by two coexisting pathogens, Leptosphaeria maculans and L. biglobosa. They coexist because of their temporal and spatial separations, which are associated with the differences in timing of their ascospore release. L. maculans produces sirodesmin PL, while L. biglobosa does not. However, their interaction/coexistence in terms of secondary metabolite production is not understood.RESULTSSecondary metabolites were extracted from liquid cultures, L. maculans only (Lm only), L. biglobosa only (Lb only), L. maculans and L. biglobosa simultaneously (Lm&Lb) or sequentially 7 days later (Lm+Lb). Sirodesmin PL or its precursors were identified in extracts from ‘Lm only’ and ‘Lm+Lb’, but not from ‘Lm&Lb’. Metabolites from ‘Lb only’, ‘Lm&Lb’ or ‘Lm+Lb’ caused significant reductions in L. maculans colony area. However, only the metabolites containing sirodesmin PL caused a significant reduction to L. biglobosa colony area. When oilseed rape cotyledons were inoculated with conidia of ‘Lm only’, ‘Lb only’ or ‘Lm&Lb’, ‘Lm only’ produced large gray lesions, while ‘Lm&Lb’ produced small dark lesions similar to lesions caused by ‘Lb only’. Sirodesmin PL was found only in the plant extracts from ‘Lm only’. These results suggest that L. biglobosa prevents the production of sirodesmin PL and its precursors by L. maculans when they grow simultaneously in vitro or in planta.CONCLUSIONFor the first time, L. biglobosa has been shown to inhibit the production of sirodesmin PL by L. maculans when interacting simultaneously with L. maculans either in vitro or in planta. This antagonistic effect of interspecific interaction may affect their coexistence and subsequent disease progression and management. © 2022 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Transient positive antimitochondrial M2 in sera of patients with connective tissue diseases after intravenous immunoglobulin infusions
Authors: Yang Lijuan , Wei Xiuning , Li Qianhua , Li Honggui , Ouyang Zhiming , Zeng Aiqi , Zheng Donghui , Dai Lie , Mo Yingqian 
Published: November 2022

AbstractBackgroundAlthough antinuclear antibodies (ANAs), anti‐SSA and anti‐Ro52, are present in immunoglobulin preparations, it is unknown whether intravenous immunoglobulin (IVIG) therapy influences the testing of serum autoantibodies in patients with connective tissue diseases (CTDs). The present study aimed to investigate the dynamic change over time of serum ANA‐related autoantibodies in patients with CTDs receiving IVIG therapy.MethodsSerum ANA‐related autoantibodies were monitored in two patients with CTD before IVIG therapy and at different times after therapy. These autoantibodies were tested in different batches of immunoglobulin preparations from seven pharmaceutical companies.ResultsOne patient developed a new ANA pattern (cytoplasmic dense fine speckled pattern, AC‐19) just after IVIG therapy. Both patients developed de novo positivity for AMA‐M2 and anti‐SSA, but returned negative 1 month after IVIG therapy. The residual liquid in patients' immunoglobulin preparations showed positive ANAs with a high titer of AC‐19 (1:640), a low titer of the nuclear fine speckled pattern (AC‐4, 1:80), positive AMA‐M2, and positive anti‐SSA. ANA‐related autoantibodies were tested in 16 batches of immunoglobulin preparations and all had positive ANAs with two patterns: AC‐19 (1:640 or 1:320) and AC‐4 (1:80). AMA‐M2 and anti‐SSA were positive in 100% of the batches.ConclusionOur study highlights high‐titer AMA‐M2 autoantibodies in immunoglobulin preparations and suggests their transient transfer into a patient's circulation via IVIG therapy. To avoid incorrect clinical decisions based on postinfusion antibody titers, our data recommend retesting 1–2 months after high‐dose IVIG immunomodulatory treatment.
Domain stabilization in probability in a fixed time for nonlinear stochastic systems via feedback control
Authors: Yin Juliang , Khoo Suiyang , Yu Xin 
Published: November 2022

AbstractThis paper is concerned with the domain stabilization in probability in a fixed time for nonlinear stochastic systems. More specifically, given a target domain , a probability and a fixed time , we aim to find suitable state feedback control laws such that the trajectory of the resulting closed‐loop system, starting from outside , will reach the target domain in the fixed time with the minimum probability . To this end, we prove a local existence and uniqueness result of solutions to nonlinear stochastic systems under mild conditions, and derive upper bounds of the mean of the first hitting time with respect to under various rigorous conditions. By these results, a Lyapunov‐based controller design is given to guarantee the domain stability for nonlinear stochastic systems with affine control inputs. Besides, inequalities of quadratic forms focusing on semi‐linear stochastic systems are used to design a linear state feedback controller for achieving the domain stability in probability. Several examples are given for demonstration.
Upgrading of Tall Fescue Grass Pyrolytic Bioliquid and Catalytic Valorization of The Biofurfural Obtained
Authors: Musci Juan J. , Casoni Andrés I. , Gutiérrez Victoria S. , Ocsachoque Marco A. , Merlo Andrea B. , Volpe María A. , Lick Ileana D. , Casella Mónica L. 
Published: November 2022

AbstractThe production of added value products following catalytic hydrogenation reactions of bioliquids was studied. These bioliquids were obtained from the pyrolysis of raw and acid‐treated (H3PO4) Tall Fescue (Fescue arundinacea) waste. Before the pyrolytic test, the biomass samples were analyzed by a micro thermogravimetric analysis coupled with FTIR spectroscopy (TGA‐IR), which enables the chemical identification of functional groups of gaseous molecules originated by solid/gas transformations. From these results, the pyrolysis temperature was selected, and bench scale pyrolysis reactions were carried out. The pyrolysis bioliquids showed high furfural concentration, 46 and 70 % for fescue and acid washed fescue, respectively. The bioliquid with the highest furfural concentration was catalytically hydrogenated in aqueous phase. A batch reactor was employed, with Ru/C and Ru−Sn/C catalysts to produce high added value alcohols.
Recent Advances in Graphene and Graphene‐Based Heterogeneous Nanocatalysts: C−C And C−Y Coupling Reactions in Liquid Phase
Authors: Paunkumar Ponnusamy , Babu Sundaram Ganesh 
Published: November 2022

AbstractUp to date, graphene has been widely used in organic transformations as a supporting material due to its superior physical and chemical properties as well as being cost‐effective. Metal nanocomposite as a catalyst has been studied in the formation of carbon‐carbon and carbon‐heteroatom bonds formation reactions such as Suzuki, Ullmann, Heck, Sonogashira, C−O, C−N, and C−S cross‐coupling reactions. The efficient catalysts were characterized by analytical and microscopic techniques and investigated their reusability. The reactions gave the desired products (pharmaceutical intermediate products) an easier path. This review mainly focuses on metal nanoparticles supported by graphene derivatives towards the C−C and C−Y (Y=O, S, N) cross‐coupling reactions in liquid phase heterogeneous catalysis.
Ag‐doped CoP Hollow Nanoboxes as Efficient Water Splitting Electrocatalysts and Antibacterial Materials
Authors: Tong Xianfeng , Liao Wenhao , Fu Yingyan , Qian Min , Dai Haojiang , Mei Lu , Zhai Yali , Chen Tianyun , Yang Liu , Yang Qinghua 
Published: November 2022

AbstractFunctionalized designs such as doping can effectively reduce charge transfer impedance and accelerate charge transfer dynamics. In this study, we reported a facile method to synthesize Ag‐doped ZIF‐67 hollow nanoboxes (Ag‐CoP HNBs) by introducing Ag into cobalt‐centered zeolitic imidazolate framework (ZIF‐67). Its unique hollow structure results in higher stability, more active sites and bigger specific surface area with excellent HER and OER performance. Specifically, Ag‐CoP HNBs requires only 97 and 256 mV to achieve a current density of 10 mA cm−2 for HER and OER in 1.0 M KOH, respectively. Meanwhile, merely a voltage of 1.53 V is needed for delivering a current density of 10 mA cm−2 for overall water splitting. Moreover, Ag‐CoP HNBs exhibits excellent antibacterial activity for different bacteria due to the presence of Ag. In conclusion, this study provided a facile, feasible and productive way for developing Ag contained bifunctional electrocatalysts with antibacterial activity, which might have potential use in seawater splitting.
Design, Synthesis, Docking, 2D‐QSAR Modelling, Anticancer and Antioxidant Evaluation of Some New Azo‐Compounds Derivatives and Investigation of Their Fluorescence Properties
Authors: Hamed Eman O. , Elsayed Doaa A. , Assy Mohamed G. , Shehab Wesam S. 
Published: November 2022

Abstract2,2′ (2,4‐dioxopentane‐3,3‐diyl) bis(diazene‐2,1‐diyl) dibenzoic acid was produced in this work, which was derived from the coupling reaction between two moles of diazonium salt and one mole of acetylacetone in an alkaline medium. Some derivatives based on this starting material were investigated. The structures of the good yielded synthesized composites were well characterized by different spectral techniques such as IR,1H‐ NMR,13C‐ NMR, and mass spectrometry. Due to the outrageous spread of cancer, these compounds were tested for the cytotoxicity against human tumor cells (HEPG‐2) and (MCF‐7) as a wide spread type of cancers in Egypt. The study illustrated that compounds11aand11bhad a very powerful effect on two separate cell lines (HEPG‐2 and MCF‐7) and compounds8and6had a strong effect. The results of anticancer were supported by molecular docking and 2D‐QSAR modeling. In addition to testing the compounds as anticancer drugs, they were examined as antioxidant by using [DPPH] technique, antimicrobial activity (gram‐positive and gram‐negative) and antifungal activity which provided satisfactory results. The fluorescence properties were tested as an analytical application for the produced substances with good results.
Synthesis of 4‐Azaindole‐morpholine‐1,3,4‐oxadiazole Conjugates as Epidermal Growth Factor Receptor Inhibitors
Authors: Hari Gangadhar Kotni , Benarjee Velaga , Ratnamala Annapragada 
Published: November 2022

AbstractHerein, we synthesized some new 4‐azaindole‐morpholine‐1,3,4‐oxadiazole conjugates (11 a–n) and evaluated for their in vitro anticancer potency towards three human cancer cell lines namely MCF‐7, A549 and HepG2 using MTT assay. Among all, compounds (1‐((5‐(4‐methoxyphenyl)‐1,3,4‐oxadiazol‐2‐yl)methyl)‐1H‐pyrrolo[3,2‐b]pyridin‐3‐yl) (morpholino) methanone (11 d), 4‐(5‐((3‐(morpholine‐4‐carbonyl)‐1H‐pyrrolo[3,2‐b]pyridin‐1‐yl)methyl)‐1,3,4‐oxadiazol‐2‐yl) benzonitrile (11 f) and (1‐((5‐(4‐chloro‐3,5‐dimethoxyphenyl)‐1,3,4‐oxadiazol‐2‐yl)methyl)‐1H‐pyrrolo[3,2‐b]pyridin‐3‐yl)(morpholino) methanone (11 k) displayed greater in vitro activity against all the cell lines than the erlotinib with IC50 values ranging from 1.12 to 14.15 μM. The active compounds 11 d, 11 f and 11 k were also screened for their inhibiting power of tyrosine kinase EGFR and results revealed that the compounds 11 d and 11 f exhibited more inhibition than the standard erlotinib. Further, docking studies of compounds 11 d, 11 f and 11 k on EGFR revealed that compound 11 d had highest binding energy (−10.37 kcal/mol). Finally, compounds 11 d and 11 f followed the rules of Lipinski, Ghose, Veber, Egan rule and Muegge rules without any deviation.
Reduced Graphene Oxide‐Gold Nanoparticle Nanohybrid Modified Cost‐Effective Paper‐Based Biosensor for Procalcitonin Detection
Authors: Gupta Yachana , Pandey Chandra Mouli , Ghrera Aditya Sharma 
Published: November 2022

AbstractThe present study reports the fabrication of reduced graphene oxide (rGO)/gold nanoparticles (AuNP) nanocomposites modified cellulose fiber paper‐based electrochemical biosensor for procalcitonin (PCT) biomarker detection. PCT is a biomarker specific for bacterial infection (BI) detection and has gained much attention as a potential solution to the problems associated with determining appropriate antibiotic use. In sepsis and other severe infections, serum PCT levels increase to values above 100 ng mL−1 in response to pro‐inflammatory stimulation. The structural and morphological characterization of the rGO‐AuNP composite are investigated using UV‐Vis spectroscopy, FTIR spectroscopy, X‐ray diffraction, and scanning electron microscopy. Monoclonal antibodies specific to PCT were covalently immobilized onto the rGO‐AuNP nanocomposite modified paper to fabricate an electrochemical biosensor. The fabricated biosensor exhibits linearity in the PCT concentration range 10 −15×103 pg mL−1, with a low detection limit 10 pg mL−1. Furthermore, the proposed biosensor also exhibited good selectivity and could detect PCT biomarkers even in the presence of other interfering electroactive species such as glucose, oxalic acid, and urea. The proposed CF‐based biosensor has been proven as an accelerated simple point‐of‐care (POC) exploratory approach for early PCT diagnosis in inadequate areas with limited production facilities, computational techniques, and highly skilled experts.
Rongalite Promoted Reductive Esterification of Sulfonyl Chlorides: An Efficient Preparation of Sulfinic Esters
Authors: Zhang Guofu , Sang Zhimin , Wu WenLiang , Fan Qiankun , Ding Chengrong 
Published: November 2022

AbstractA method for the synthesis of sulfinic esters was developed by using rongalite [CH2(OH)SO2Na] promoted esterification of sulfonyl chloride with alcohol. Various functional groups are compatible with the green strategy. It can be easily executed at gram level. Furthermore, mechanistic studies confirmed that this process can proceed via a radical mechanism. It represents a new method for green and efficient conversion of readily available sulfonyl chloride.
Benzimidazolium Ionic‐Liquid‐Functionalized Star‐shaped Copolymer Stationary Phase for Capillary Gas Chromatography
Authors: Chen Ruonan , Cai Zhiqiang , Huang Qiuchen , Zhang Wei , Jin Keyun , Zhao Yi , Li Yiwen , Sun Tao , Ji Hongying , Li Shuai 
Published: November 2022

AbstractIn this work, a novel star‐shaped copolymer functionalized by benzimidazolium ionic liquid (Star‐PEG‐PCL2‐2Bim) was synthesized and applied as stationary phase in capillary gas chromatography (GC). After static coating, the Star‐PEG‐PCL2‐2Bim column exhibited a column efficiency of 2655 plates/m and moderate polarity. The Star‐PEG‐PCL2‐2Bim column showed preferential retention and high resolving capability for hydrogen‐bonded and aromatic analytes, showing advantages over the ordinary polysiloxane phase. Impressively, it attained high resolution for the isomer mixtures of halogenated benzene, nitrobenzene, phenol and benzaldehydes with good peak shapes. The advantageous separation performance shows the good potential of the Star‐PEG‐PCL2‐2Bim stationary phase for GC analysis.
Superstructures of Zeolitic Imidazolate Frameworks to Single‐ and Multiatom Sites for Electrochemical Energy Conversion
Authors: Patil Rahul , Liu Shude , Yadav Anubha , Khaorapapong Nithima , Yamauchi Yusuke , Dutta Saikat 
Published: November 2022

AbstractThe exploration of electrocatalysts with high catalytic activity and long‐term stability for electrochemical energy conversion is significant yet remains challenging. Zeolitic imidazolate framework (ZIF)‐derived superstructures are a source of atomic‐site‐containing electrocatalysts. These atomic sites anchor the guest encapsulation and self‐assembly of aspheric polyhedral particles produced using microreactor fabrication. This review provides an overview of ZIF‐derived superstructures by highlighting some of the key structural types, such as open carbon cages, 1D superstructures, hollow structures, and the interconversion of superstructures. The fundamentals and representative structures are outlined to demonstrate the role of superstructures in the construction of materials with atomic sites, such as single‐ and dual‐atom materials. Then, the roles of ZIF‐derived single‐atom sites for the electroreduction of CO2 and electrochemical synthesis of H2O2 are discussed, and their electrochemical performance for energy conversion is outlined. Finally, the perspective on advancing single‐ and dual‐atom electrode‐based electrochemical processes with enhanced redox activity and a low‐impedance charge‐transfer pathway for cathodes is provided. The challenges associated with ZIF‐derived superstructures for electrochemical energy conversion are discussed.
Deterministic Excitation of Polarization‐Sensitive Extrinsic Anapole State in Si Nanodisk Clusters
Authors: Ma Churong , Zhou Fangrong , Huang Pengfei , Li Meng , Zhao Feng , Feng Ziwei , Liu Ying , Li Xiangping , Guan Bai‐ou , Chen Kai 
Published: November 2022

AbstractNanoparticle clusters provide new degrees of freedom for light control due to their mutual interaction compared with an individual one. Here, the authors demonstrate theoretically and experimentally a type of optical anapole (a nonradiating state) termed as extrinsic anapole, with mode field spreading across Si nanodisk dimers unlike the intrinsic one that is confined within individual nanodisks. The extrinsic anapole is sensitive to the polarized excitation. When the electric vector E of excitation is perpendicular to the dimer axis, the coupled toroidal dipole (TD) mode is largely enhanced and broadened to be spectrally overlapped with the electric dipole (ED) mode. The destructive interference of these two modes results in the generation of the extrinsic anapole. However, it vanishes when E is parallel to the dimer axis. Such polarization dependence can be relieved with the participation of the third nanodisk. Scattering spectra of Si nanodisk trimers stay almost unchanged under different polarized excitations, although the near‐field distributions are quite different. Finally, enhanced white‐light emission is observed in Si nanodisk clusters, which can be attributed to the near‐infrared absorption enhancement induced by extrinsic anapole states. The findings manifest that high‐index all‐dielectric nanodisk clusters are promising for light manipulation based on mode interference.
Synergy of Platinum Single Atoms and Platinum Atomic Clusters on Sulfur‐Doped Titanium Nitride Nanotubes for Enhanced Hydrogen Evolution Reaction
Authors: Yan Jing , Xi Zichao , Cong Linlin , Lv Kun , Xin Ruiyun , Cao Bo , Liu Baocang , He Jinlu , Zhang Jun 
Published: November 2022

AbstractHighly dispersed Pt, such as Pt single atoms and atomic clusters, has great potential in the electrocatalytic hydrogen evolution reaction (HER) due to the high atomic efficiency and unique electronic configuration. Rationally regrating the electronic structure of Pt catalysts is desirable for promoting the HER performance. Herein, a 3D self‐supported monolithic electrode consisting of Pt single atoms (PtSAs) and Pt atomic clusters (PtACs) anchored on sulfur‐doped titanium nitride nanotubes (S‐TiN NTs) encapsulated in polyaniline (PANI) on Ti mesh (PANI@Pt/S‐TiN NTs/Ti) via a facile electrochemical strategy for efficient HER is designed and synthesized. Contributed by the unique structure and composition and the synergy of PtSAs, PtACs and S‐TiN NTs, the PANI@Pt/S‐TiN NTs/Ti electrode exhibits ultrahigh HER activities with only 12, 25 and 39 mV overpotentials at −10 mA cm−2 in acidic, alkaline and neutral media, respectively, and can maintain a stable performance for 25 h. Impressively, the mass activities are respectively up to 26.1, 22.4, and 17.7 times as that of Pt/C/CC electrode. Theoretical calculation results show that the synergistic effect of PtSAs, PtACs, and S‐TiN NTs can optimize the electronic structure of Pt and generate multiple active sites with a thermodynamically favorable hydrogen adsorption free energy (ΔGH*), thereby resulting in an enhanced HER activity.
Persistent urachal remnant in a 3‐year‐old guinea pig
Authors: Baldrey Vicki , Hedley Joanna , Davidson Gordon , Skarbek Adrianna , Martineau Henny 
Published: November 2022

AbstractA 3‐year‐old, female, entire guinea pig presented with an 8‐week history of dysuria and vocalising when urinating. Investigations included radiography, ultrasonograpy and urine culture, which did not yield a definitive diagnosis. Medical management continued over a 3‐month period during which time, the clinical signs waxed and waned. A computed tomography scan was performed, which revealed cystitis, cystolithiasis and evidence of a persistent urachal remnant. Surgical resection of the urachal remnant was performed. The guinea pig made a good recovery from the procedure, and clinical signs have not returned 9 months later.