bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative analysis of low intensity ultrasound effects on living cells: from simulation to experiments
Authors: Tamboia Giulia , Campanini Michele , Vighetto Veronica , Racca Luisa , Spigarelli Luca , Canavese Giancarlo , Cauda Valentina 
Published: October 2022

AbstractUltrasounds are already broadly exploited in clinical diagnostics and are now becoming a powerful and not harmful tool in antitumoral therapies, as they are able to produce damages towards cancer cells, thank to inertial cavitation and temperature increase. The use of US alone or combined to molecular compounds, microbubbles or solid-state nanoparticles is the focus of current research and clinical trials, like thermoablation, drug sonoporation or sonodynamic therapies. In the present work, we discuss on the non-thermal effects of ultrasound and the conditions which enable oxygen radical production and which role they can have in provoking the death of different cancer cell lines. In this perspective, we set a mathematical model to predict the pressure spatial distribution in a defined water sample volume and thus obtain a map of acoustic pressures and acoustic intensities of the applied ultrasound at different input powers. We then validate and verify these numerical results with direct acoustic measurements and by detecting the production of reactive oxygen species (ROS) by means of sonochemiluminescence (SCL) and electron paramagnetic resonance (EPR) spectroscopy, applied to the same water sample volume and using the same US input parameters adopted in the simulation. Finally, the various US conditions are applied to two different set of cancer cell lines, a cervical adenocarcinoma and a hematological cancer, Burkitt’s lymphoma. We hypothesize how the ROS generation can influence the recorded cell death. In a second set of experiments, the role of semiconductor metal oxide nanocrystals, i.e. zinc oxide, is also evaluated by adding them to the water and biological systems. In particular, the role of ZnO in enhancing the ROS production is verified. Furthermore, the interplay among US and ZnO nanocrystals is evaluated in provoking cancer cell death at specific conditions. This study demonstrates a useful correlation between numerical simulation and experimental acoustic validation as well as with ROS measurement at both qualitative and quantitative levels during US irradiation of simple water solution. It further tries to translate the obtained results to justify one of the possible mechanisms responsible of cancer cell death. It thus aims to pave the way for the use of US in cancer therapy and a better understanding on the non-thermal effect that a specific set of US parameters can have on cancer cells cultured in vitro.
Graphical abstract
PIK3CA-mutations in breast cancer
Authors: Reinhardt Kristin , Stückrath Kathrin , Hartung Carolin , Kaufhold Sandy , Uleer Christoph , Hanf Volker , Lantzsch Tillmann , Peschel Susanne , John Jutta , Pöhler Marleen , Bauer Marcus , Bürrig Friedrich Karl , Weigert Edith , Buchmann Jörg , Kantelhardt Eva Johanna , Thomssen Christoph , Vetter Martina 
Published: October 2022

Abstract
Purpose
Phosphatidylinositide-3-kinase (PI3K) regulates proliferation and apoptosis; somatic PIK3CA-mutations may activate these processes. Aim of this study was to determine the prevalence of PIK3CA-mutations in a cohort of early stage breast cancer patients and the association to the course of disease.

Patients and methods
From an unselected cohort of 1270 breast cancer patients (PiA, Prognostic Assessment in routine application, NCT 01592825) 1123 tumours were tested for the three PIK3CA hotspot-mutations H1047R, E545K, and E542K by qPCR. Primary objectives were the prevalence of somatic PIK3CA-mutations and their association to tumour characteristics. Secondary objective was the association of PIK3CA-mutations to recurrence-free interval (RFI) and overall survival.

Results
PIK3CA-mutation rate was 26.7% (300 of 1123). PIK3CA-mutations were significantly more frequent in steroid hormone-receptor (SHR)-positive HER2-negative (31.4%), and G1 and G2 tumours (32.8%). Overall, we did not observe a significant association of PIK3CA-mutations to RFI. In SHR-positive BCs with PIK3CA-mutations, a strong trend for impaired RFI was observed (adjusted HR 1.64, 95% CI 0.958–2.807), whilst in SHR-negative BCs PIK3CA-mutations were insignificantly associated with improved RFI (adjusted HR 0.49; 95% CI 0.152–1.597). Of note, we observed a significantly detrimental prognostic impact of PIK3CA-mutations on RFI in SHR-positive, HER2-negative BCs if only aromatase inhibitors were administered as adjuvant therapy (adjusted HR 4.44, 95% CI 1.385–13.920), whilst no impact was observed in tamoxifen treated patients.

Conclusion
This cohort study speficies the overall mutation rate of PIK3CA in early breast cancer. The impact of PIK3CA-mutations on RFI and OS was heterogeneous. Our results suggest that estrogen deprivation failes to be active in case of PIK3CA-mutation.
Life Around the Elephant in Space and Time: an Integrated Approach to Study the Human-Elephant Interactions at the Late Lower Paleolithic Site of La Polledrara di Cecanibbio (Rome, Italy)
Authors: Lemorini Cristina , Santucci Ernesto , Caricola Isabella , Nucara Alessandro , Nunziante-Cesaro Stella 
Published: October 2022

Abstract
During the Lower Paleolithic, the interaction between hominins and elephants through the medium of lithic tools is testified by numerous sites in Africa, Europe, and Asia. This interaction ensured hominins a large source of food and of knappable raw material, bone. The availability of the huge package of resources represented by these animals had a deep impact on hominins behavior and their strategies of exploitation of the landscape. This article, for the first time, documents this behavior with a spatial and chronological viewpoint. At the Late Lower Paleolithic site of La Polledrara di Cecanibbio (Rome), the outstanding in situ find of a quite entire carcass of Palaeoloxodon antiquus surrounded by lithic tools of small dimensions allowed us to explore the relation between the elephant, fatally entrapped in muddy sediments, and the hominins that exploited its carcass with their lithic toolkit. The application of an integrated approach including technology, refitting, use-wear, residues, and spatial analyses to the study of the small tools allowed us to unveil the activities carried out around the elephant in a timeline. As a result, hominins exploited the carcass for meat and fat possibly in more than one time and selected the area of the carcass as an atelier to knap and possibly cache their lithic products for future use. These data introduce the intriguing suggestion that the carcass was, besides a source of food and raw material, also a landmark for humans in the landscape.
Meta’s Oversight Board: A Review and Critical Assessment
Authors: Wong David , Floridi Luciano 
Published: October 2022

AbstractSince the announcement and establishment of the Oversight Board (OB) by the technology company Meta as an independent institution reviewing Facebook and Instagram’s content moderation decisions, the OB has been subjected to scholarly scrutiny ranging from praise to criticism. However, there is currently no overarching framework for understanding the OB’s various strengths and weaknesses. Consequently, this article analyses, organises, and supplements academic literature, news articles, and Meta and OB documents to understand the OB’s strengths and weaknesses and how it can be improved. Significant strengths include its ability to enhance the transparency of content moderation decisions and processes, to effect reform indirectly through policy recommendations, and its assertiveness in interpreting its jurisdiction and overruling Meta. Significant weaknesses include its limited jurisdiction, limited impact, Meta’s control over the OB’s precedent, and its lack of diversity. The analysis of a recent OB case in Ethiopia shows these strengths and weaknesses in practice. The OB’s relationship with Meta and governments will lead to challenges and opportunities shaping its future development. Reforms to the OB should improve the OB’s control over its precedent, apply OB precedent to currently disputed cases, and clarify the standards for invoking OB precedent. Finally, these reforms provide the foundation for an additional improvement to address the OB’s institutional weaknesses, by involving users in determining whether the OB’s precedent should be applied to decide current content moderation disputes.
Satisfaction and Perceived Coercion in Voluntary Hospitalisations: Impact of Past Coercive Experiences
Authors: Martinez Debora , Brodard Alexandra , Silva Benedetta , Diringer Oana , Bonsack Charles , Morandi Stéphane , Golay Philippe 
Published: October 2022

AbstractCoercion in psychiatry is associated with several detrimental effects, including in the long term. The effect of past experience of coercion on the perception of subsequent hospitalisations remains less studied. The present study aimed to assess the impact of past experience of coercion on the perception of coercion and satisfaction with subsequent voluntary hospitalisations. A total of 140 patients who were hospitalised on a voluntary basis were included. Fifty-three patients experienced coercion before this hospitalisation and 87 did not. Patients were assessed for treatment satisfaction and perceived coercion. Health status was also evaluated by both patients and carers. Past experience of coercion was the independent variable. Perceived coercion and satisfaction scores were used as different dependent variables in a series of regression models. Results suggested a long-term detrimental impact of past experience of coercion on some aspects of satisfaction and perceived coercion in subsequent voluntary hospitalisations even when controlling for self and carers-rated health status. Overall, this study suggests that special attention should be paid to patients who are voluntarily admitted to hospital but have a history of coercion, as they may still be impacted by their past coercive experiences. Ways to increase satisfaction and reduce perceived coercion of these patients are discussed.
The asymmetric mispricing information in analysts’ target prices
Authors: Green Jeremiah , Hand John R. M. , Sikochi Anywhere 
Published: October 2022

AbstractWe study the mispricing information present in the target prices of US and international analysts. We hypothesize that asymmetry in the value-relevance of the information that managers supply to analysts, combined with asymmetry in the incentives facing analysts to curry favor with managers, leads to analyst-claimed undervaluation being more predictive of future stock returns than analyst-claimed overvaluation. Our empirical tests isolate analyst-claimed mispricing by first removing analysts’ estimates of the cost of equity from the returns implied by target prices and then separating analyst-claimed undervaluation from overvaluation. We find that target prices only predict future returns (at 16 cents to 18 cents on the dollar) when analysts claim undervaluation, not when they claim overvaluation. We also observe that analyst-claimed undervaluation predicts future returns more strongly after firms experience low returns and when macro-driven valuation uncertainty is low.
Apparent prevalence and risk factors for bovine tuberculosis in the state of Paraná, Brazil: an assessment after 18 years since the beginning of the Brazilian program
Authors: Rodrigues Diego Leonardo , Amorim Elenice Aparecida , Ferreira Fernando , Amaku Marcos , Baquero Oswaldo Santos , de Hildebrand e Grisi Filho José Henrique , Dias Ricardo Augusto , Heinemann Marcos Bryan , Telles Evelise Oliveira , Gonçalves Vitor Salvador Picão , Compton Christopher , Ferreira Neto José Soares 
Published: October 2022

AbstractBovine tuberculosis (bTB) impacts considerably animal production and one health worldwide. To describe the prevalence, risk factors, and spatial pattern of the disease in the state of Paraná, Brazil, a cross-sectional study was conducted from September 2018 to February 2019. The area was divided into seven regions. Within each region, farms were randomly selected, and a predetermined number of cows was selected and tested by a comparative cervical tuberculin test. 17,210 animals were tested across 1757 farms. Herd prevalence of bTB-infected herds in Paraná was 2.5% [1.87–3.00%]. It has varied from 0.8 to 3.98% among seven regions, with clustering being detected in the west, central, and northeast areas. Animal prevalence was 0.35% [0.21–0.59%] and has varied from 0.08 to 0.6% among the pre-set regions. No major shifts in the prevalence of bTB were detected since 2007. Large-sized herds, dairy production, and feeding with whey were detected to be correlated with the presence of bTB. Exclusively among dairy herds, veterinary assistance from cooperatives, possession of self-owned equipment to cool milk, and feeding with whey were correlated with the disease. Considering these results, it is recommended that the state of Paraná seek to implement a surveillance system for the detection of bTB-infected herds transforming them into free ones, if possible, incorporating elements of risk-based surveillance. Health education is also recommended to inform farmers about the risks of introducing animals without testing and of feeding raw whey to calves.
First-year university students' self-regulated learning during the COVID-19 pandemic: a qualitative longitudinal study
Authors: Liebendörfer Michael , Kempen Leander , Schukajlow Stanislaw 
Published: October 2022

AbstractWhen the COVID-19 pandemic began, many universities switched to fully online teaching. This unexpected switching to online teaching was challenging for both teachers and students, and restrictions that were put in place because of pandemic made this challenge even greater. However, new ways of teaching might also open new opportunities for students’ learning. The research question driving our study was as follows: how do students regulate their learning and specifically their choice of resources and peer learning in university mathematics classes that are fully taught online as offered during the COVID-19 pandemic? We report on a longitudinal, qualitative study in which students recorded a brief audio diary twice a week over one whole semester (14 weeks). We focused on three students who completed 70 interviews in total and finished the semester with varying degrees of success. The results show how the students structured their studying (e.g., the roles that deadlines or synchronous teaching events played). They illustrate the strengths and limitations of digital materials provided by the lecturer and the use of complementary media. Further, the pandemic uncovered the double-edged role of simple, often anonymous exchanges (e.g., via Discord servers), with few binding forces for either side, and the significance of stable learning partnerships for students’ success. Our research highlights aspects that should be focal points when comparing traditional instruction and online instruction during the pandemic from a self-regulatory perspective. Practical implications refer to how these aspects can be combined sensibly in fully online courses, but also in blended learning contexts.
The role of polysulfide-saturation in electrolytes for high power applications of real world Li-S pouch cells
Authors: Boenke Tom , Kirchhoff Sebastian , Reuter Florian S. , Schmidt Florian , Weller Christine , Dörfler Susanne , Schwedtmann Kai , Härtel Paul , Abendroth Thomas , Althues Holger , Weigand Jan J. , Kaskel Stefan 
Published: October 2022

AbstractThe lithium-sulfur (Li-S) technology is the most promising candidate for next-generation batteries due to its high theoretical specific energy and steady progress for applications requiring lightweight batteries such as aviation or heavy electric vehicles. For these applications, however, the rate capability of Li-S cells requires significant improvement. Advanced electrolyte formulations in Li-S batteries enable new pathways for cell development and adjustment of all components. However, their rate capability at pouch cell level is often neither evaluated nor compared to state of the art (SOTA) LiTFSI/dimethoxyethane/dioxolane (LITFSI: lithium-bis(trifluoromethylsulfonyl)imide) electrolyte. Herein, the combination of the sparingly polysulfide (PS) solvating hexylmethylether/1,2-dimethoxyethane (HME/DME) electrolyte and highly conductive carbon nanotube Buckypaper (CNT-BP) with low porosity was evaluated in both coin and pouch cells and compared to dimethoxyethane/dioxolane reference electrolyte. An advanced sulfur transfer melt infiltration was employed for cathode production with CNT-BP. The Li+ ion coordination in the HME/DME electrolyte was investigated by nuclear magnetic resonance (NMR) and Raman spectroscopy. Additionally, ionic conductivity and viscosity was investigated for the pristine electrolyte and a polysulfide-statured solution. Both electrolytes, DME/DOL-1/1 (DOL: 1,3-dioxolane) and HME/DME-8/2, are then combined with CNT-BP and transferred to multi-layered pouch cells. This study reveals that the ionic conductivity of the electrolyte increases drastically over state of (dis)charge especially for DME/DOL electrolyte and lean electrolyte regime leading to a better rate capability for the sparingly polysulfide solvating electrolyte. The evaluation in prototype cells is an important step towards bespoke adaption of Li-S batteries for practical applications.
Emerging noble metal-free Mo-based bifunctional catalysts for electrochemical energy conversion
Authors: Santra Saswati , Streibel Verena , Sharp Ian D. 
Published: October 2022

AbstractThe transition from a global economy dependent on fossil fuels to one based on sustainable energy conversion technologies presents the primary challenge of the day. Equipping water electrolyzers and metal-air batteries with earth-abundant bifunctional transition metal (TM) catalysts that efficiently catalyse the hydrogen and oxygen evolution reactions (HER and OER) and the oxygen reduction and evolution reactions (ORR and OER), respectively, reduces the cost and system complexity, while also providing prospects for accelerated scaling and sustainable material reuse. Among the TMs, earth-abundant molybdenum (Mo)-based multifunctional catalysts are especially promising and have attracted considerable attention in recent years. Starting with a brief introduction to HER, OER, and ORR mechanisms and parameters governing their bifunctionality, this comprehensive review focuses on such Mo-based multifunctional catalysts. We review and discuss recent progress achieved through the formation of Mo-based compounds, heterostructures, and nanoscale composites, as well as by doping, defect engineering, and nanoscale sculpting of Mo-based catalysts. The systems discussed in detail are based on Mo chalcogenides, carbides, oxides, nitrides, and phosphides, as well as Mo alloys, highlighting specific opportunities afforded by synergistic interactions of Mo with both non-metals and non-noble metals. Finally, we discuss the future of Mo-based multifunctional electrocatalysts for HER/OER, ORR/OER, and HER/ORR/OER, analysing emerging trends, new opportunities, and underexplored avenues in this promising materials space.
Impact-Relation Map of Innovative Service Development Regarding the Sustainable Growth for Emerging Markets
Authors: Kafka Kyriaki I. , Dinçer Hasan , Yüksel Serhat 
Published: October 2022

AbstractThis paper introduces a tool for new service development in the context of emerging economies. For this aim, two-stage decision making model is applied for measuring the new service development-enhanced sustainable growth of emerging economies. At the first stage, bipolar q-ROF M-SWARA with golden cut is used for weighting the new service development process. At the second stage, bipolar q-ROF ELECTRE with golden cut is employed for illustrating the impact-relation map of sustainable growth determinants with respect to the new service development process for emerging economies. The novelties of this study are to construct a novel decision-making approach by using the bipolar q-ROFSs and golden cut and to figure out the influencing degrees and directions of sustainable growth determinants for emerging economies. It is also determined that testing has the highest significance while creating a new service for sustainable growth. Ranking results also demonstrate that qualified organizational teams and equipment is the most critical factor regarding innovative service process-based sustainable growth. It is necessary to adapt current technological developments to new products to be developed for sustainable growth. In this context, technological advances for these products should be followed carefully. In this process, it would be appropriate for companies to reach this goal by employing qualified personnel.
Linking Digital Capacity to Innovation Performance: the Mediating Role of Absorptive Capacity
Authors: Kastelli Ioanna , Dimas Petros , Stamopoulos Dimitrios , Tsakanikas Aggelos 
Published: October 2022

Abstract
Digital technologies are considered as factors that accelerate the pace of innovation and increase the firm’s innovation performance. However, few studies have investigated whether this claim is conditioned by other elements that contribute to innovation. Furthermore, firms increasingly rely on external knowledge sources to expand their internal knowledge base for the development of innovations. In this context, absorptive capacity can be considered as an essential organizational capability to embrace adoption of digital technologies and enhance their positive effect on innovation performance. This paper builds on this discussion and studies the contribution of digital capacity on innovation performance, proposing the mediating role of absorptive capacity in the context of the digital transformation. It uses evidence from an extensive Greek survey in 1014 manufacturing firms and analyzes the complex relationships underlying the role of digital transformation to innovation. The contribution of the paper is two-fold: (i) it provides a deeper insight into the underlying mechanisms through which firms can leverage their digital capacity to accelerate innovation, and (ii) it highlights the important mediating role of absorptive capacity in enhancing the positive effects of digitalization indicating that digital capacity is not an unquestionable asset for innovation performance. Accordingly, our results show a positive direct contribution of digital capacity to innovation performance, which is enhanced in the presence of absorptive capacity as a mediator. In fact, the indirect effect of digital capacity to innovation performance through absorptive capacity is stronger. These findings present important policy implications, as there is need for improvement in other innovation-related aspects of the business ecosystem to efficiently address the challenge of digital transformation, such as R&D efforts, training, interaction among actors, and building of communities of practice.