bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness of on-demand removal of syndesmotic screws
Authors: Penning D. , Sanders F. R. K. , van Dieren S. , Roukema G. R. , Vermeulen J. , Winkelhagen J. , Goslings J. C. , Schepers T. ,   RODEO collaborator group, van den Bekerom M. P. , van Dijkman B. , Halm J. A. , Hoogendoorn J. M. , Parkkinen M. , van Veen R. N. 
Published: November 2022

Abstract
Purpose
Syndesmotic screw removal following acute syndesmotic injury is a commonly performed procedure. However, recent studies suggest that the removal does not result in improved patient reported outcome, while the procedure has proved not to be without complications. The aim of this study was to present a health-economic evaluation of on-demand removal (ODR) compared to routine removal (RR) of the syndesmotic screw.

Methods
Data were collected from the RODEO trial, a randomized controlled non-inferiority trial comparing functional outcome of ODR with RR. Economic evaluation resulted in total costs, costs (in Euro) per quality adjusted life year (QALY) and costs per point improvement on the Olerud Molander Ankle Score (OMAS). This included both direct and indirect costs.

Results
Total costs for ODR were significantly lower with a mean difference of 3160 euro compared to RR (p < 0.001). The difference in QALY was not significant. The difference in OMAS at 12 months was 1.79 with an incremental cost-effectiveness ratio (ICER) of €-1763 (p = 0.512). The ICER was well below the willingness to pay. Although unit costs might vary between hospitals and countries, these results provide relevant data of cost-effectiveness.

Conclusion
The clinical effectiveness of both ODR and RR can be considered equal. The costs are lower for patients treated with ODR, which leads to the conclusion that ODR is cost-effective.
A systematic approach for product modelling and function integration to support adaptive redesign of product variants
Authors: Wong Foo Shing , Wynn David C. 
Published: November 2022

AbstractWhen a product variant offers functionality that is high in demand, firms may decide to leverage that design to enhance other variants in their product line. This can be achieved by extracting functions and their realisations from one product variant and integrating them into another variant, resulting in a third product variant that has a new combination of functions and physical features. This article introduces a systematic approach called the ﻿Adaptive Redesign Method (ARM) to support this function integration process. The ARM is based on a new product model called the Detailed Design Model (DDM). In comparison to existing approaches, the DDM allows the architecture of an existing product to be modelled on a sufficiently detailed level to identify geometric features and parts that realise particular operating functions of a product. This detailed information provides a basis for systematic determination of the redesign activities needed to derive a new variant design, down to the detailed level of adding, removing and integrating specific parts and features. The main benefit is to assist with planning the redesign process while ensuring nothing is overlooked, which might be especially useful if the task is to be divided among several designers or if designers are not fully familiar with the designs at hand. A secondary benefit is to show how this type of redesign process can be decomposed into systematic steps, which could potentially reveal opportunities for computer support. The new approach has been developed and tested through reverse engineering studies of consumer products, confirming its applicability.
Hemi-hamate donor site morbidity and complications: a systematic review
Authors: Hamilton Sam J. , Tang Nicholas S. J. , Zhou Jieyun , Davis Katherine A. , Leong James C. 
Published: November 2022

AbstractBackgroundThe hemi-hamate arthroplasty is utilised for the management of complex fracture-dislocations for injuries of the proximal interphalangeal joints (PIPJ) of the fingers. PIPJ outcomes are well described, including the post-operative range of motion, grip strength and osteochondral graft union. However, there is a paucity of evidence analysing the rate of donor site morbidity and complications. This systematic review aims to present the published morbidity of the donor site for the hemi-hamate arthroplasty.MethodsA search was conducted in MEDLINE, Embase, Emcare, CINAHL and ProQuest Nursing and Allied Health databases from their inception which yielded 384 articles to be screened. Pertinent anatomy, harvesting techniques and post-operative donor site care of the hemi-hamate arthroplasty is reviewed.ResultsOne hundred three cases of hemi-hamate arthroplasty were included in this review with seven (6.8%) complications presented, one of which required operative intervention.ConclusionDonor site morbidity resulting from harvesting an osteochondral graft for a hemi-hamate arthroplasty is low. The overall quality of evidence from the studies in this review is low, highlighting the need for further robust prospective trials.Level of evidenceNot gradable.
Congenital syphilis in the twenty-first century: an area-based study
Authors: Salomè Serena , Cambriglia Maria Donata , Scarano Sara Maria , Capone Eleonora , Betts Ivy , Pacella Daniela , Sansone Matilde , Mazzarelli Laura Letizia , Lo Vecchio Andrea , Ranucci Giusy , Marinosci Geremia Zito , Capasso Letizia , Salvatore Paola , Raimondi Francesco 
Published: November 2022

Abstract
The resurgence of syphilis and subsequent risk for newborns has been described worldwide; however, European data on this congenital infection is lacking. We report the activity of a multidisciplinary specialized unit assisting a large area in the Southern Italy. A retrospective cohort study has been conducted at the Perinatal and Pediatric Infectious Diseases Units of the Federico II University of Naples, enrolling all newborns and children referred from January 2010 to June 2022 exposed to Treponema pallidum in utero and/or congenitally infected. A total of 323 patients were included in the analysis. Twenty (6.2%) received a diagnosis of confirmed congenital syphilis (CS) and one died. Fifteen CS cases had typical clinical features. Since 2017, the number of referred neonates tripled while the rate of late maternal diagnoses did not significantly differ. When compared with mothers of exposed infants, mothers of CS cases were younger (25 ± 7.2 vs 29.9 ± 6 years, p = 0.041), had less previous pregnancies (0.64 vs 1.11, p = 0.044), and received a diagnosis of syphilis at a later stage of pregnancy (86% vs 20%, from third trimester or later on; p < 0.001). Appropriate maternal therapy was protective against vertical transmission (− 1.2; − 1.4, − 1 95% CI; p < 0.001). Paternal syphilis status was known in 36% of cases.Conclusion: CS has still a significant impact. Prevention should be implemented towards specific maternal risk profiles. A specialized unit is the preferable model to improve surveillance and healthcare for this neglected population.

What is Known:• The resurgence of syphilis and subsequent risk for newborns has been described worldwide.• European data on this congenital infection is lacking.

What is New:• Congenital syphilis has a significant impact still in Europe and prevention should be implemented towards specific maternal risk profiles. • A specialized unit is the preferable model to improve surveillance and healthcare for this neglected population.
Parenting boys with conduct problems and callous-unemotional traits: parent and child perspectives
Authors: Roberts Ruth , McCrory Eamon , Joffe Helene , Phillips Harriet , Gaule Anne , Viding Essi 
Published: November 2022

AbstractParenting children with conduct problems (CP) is challenging, yet very little research has examined parenting using both quantitative and qualitative methods, from the perspective of the child and their parent/caregiver, and separately for those with high vs. low levels of callous-unemotional traits (HCU vs. LCU). One hundred and forty-six boys aged 11–16 [Typically developing (TD) n = 31; CP/HCU n = 35; CP/LCU n = 35] and their parents/caregivers completed the Alabama Parenting Questionnaire and provided a written qualitative statement describing their respective experiences of parenting/being parented. Parents/caregivers of CP/HCU boys reported more difficulty with child monitoring and supervision than parents of TD boys. This was echoed in qualitative reports of parents of CP/HCU boys reporting concerns regarding their child’s safety. Parents/caregivers of both groups of CP boys reported more inconsistent discipline than parents of TD boys. Parental qualitative descriptions of challenging behavior in CP/HCU boys, and difficulties with setting boundaries and motivating CP/LCU boys, provided further insight to the potential triggers for inconsistent discipline. Qualitative reports from boys with CP indicated that they understood the parenting challenges their parents/caregivers faced. These findings replicate and extend previous work on the associations between parenting and CP. Children with CP/HCU and CP/LCU show some commonalities and differences in their parenting experiences and CP children and their parents/caregivers do not necessarily share all the same perceptions or concerns. CP interventions often involve parent/family engagement and this research highlights the continued importance of examining both parent and child perspectives.
Prognostic impact of tumor microenvironment-related markers in patients with adenocarcinoma of the lung
Authors: Sugai Mayu , Yanagawa Naoki , Shikanai Shunsuke , Osakabe Mitsumasa , Maemondo Makoto , Saito Hajime , Sugai Tamotsu 
Published: November 2022

AbstractCancer-associated fibroblasts (CAFs) are a prominent component in the tumor microenvironment (TME), which plays an important role in lung carcinogenesis. Here, we investigated microenvironmental markers expressed by CAFs, including α-smooth muscle actin, CD10, podoplanin, fibroblast-specific protein 1, platelet-derived growth factor α and β, fibroblast-associated protein, tenascin-C, zinc finger E-box binding homeobox 1 (ZEB1), and twist-related protein 1 expression levels. We evaluated samples from 257 patients with lung adenocarcinoma (LAD) to assess the associations of CAF-related protein expression patterns with prognosis. LAD cases were stratified using cluster analysis. To determine the utility of prognostic markers in LAD, univariate and multivariate analyses were performed. LAD cases were classified into subgroups 1 and 2. Subgroup 2 was shown to be significantly correlated with disease-free and overall survival using univariate and multivariate analyses in this group. Upregulation of podoplanin was identified as a single prognostic marker in this study by univariate and multivariate analyses. In addition, ZEB1 overexpression was correlated with disease-free survival. Our current results suggested that the specific CAF phenotype (e.g., the expression pattern of CAF-related proteins) could predict outcomes in patients with LAD. In addition, podoplanin upregulation may predict outcomes in these patients.
Exploring pattern recognition: what is the relationship between the recognition of words, faces and other objects?
Authors: Maratos F. A. , Chu K. , Lipka S. , Stupple E. J. N. , Parente F. 
Published: November 2022

AbstractDebate surrounds processes of visual recognition, with no consensus as to whether recognition of distinct object categories (faces, bodies, cars, and words) is domain specific or subserved by domain-general visual recognition mechanisms. Here, we investigated correlations between the performance of 74 participants on recognition tasks for words, faces and other object categories. Participants completed a counter-balanced test battery of the Cambridge Face, Car and Body Parts Memory tests, as well as a standard four category lexical decision task, with response time and recognition accuracy as dependent variables. Results revealed significant correlations across domains for both recognition accuracy and response time, providing some support for domain-general pattern recognition. Further exploration of the data using principal component analysis (PCA) revealed a two-component model for both the response time and accuracy data. However, how the various word and object recognition tasks fitted these components varied considerably but did hint at familiarity/expertise as a common factor. In sum, we argue a complex relationship exists between domain-specific processing and domain-general processing, but that this is shaped by expertise. To further our understanding of pattern recognition, research investigating the recognition of words, faces and other objects in dyslexic individuals is recommended, as is research exploiting neuroimaging methodologies, with excellent temporal resolution, to chart the temporal specifics of different forms of visual pattern recognition.
First detection of resistance to deltamethrin in Spanish populations of the Mediterranean fruit fly, Ceratitis capitata
Authors: Castells-Sierra Javier , Guillem-Amat Ana , López-Errasquín Elena , Sánchez Lucas , Ortego Félix 
Published: November 2022

AbstractThe control of the Mediterranean fruit fly (Medfly), Ceratitis capitata, in citrus orchards in Spain is mainly based in three insecticides (spinosad, lambda-cyhalothrin and deltamethrin) and the liberation of sterile males. However, Medfly control is compromised by the development of lambda-cyhalothrin resistance and the detection of spinosad-resistant alleles in field populations. We report here, for the first time, resistance to deltamethrin in populations collected in fields under different management strategies, including MagnetMed™ traps coated with this insecticide and/or spinosad and lambda-cyhalothrin used as bait sprays, and even in populations obtained from non-treated fields. Two deltamethrin-resistant strains (BP-delta and Rfg-delta) were generated from the descendants of some of the field populations that showed lower susceptibility to deltamethrin. Both strains showed low susceptibility to MagnetMed™ traps, moderate susceptibility to Ceratipack traps, and lacked cross-resistance to spinosad and lambda cyhalothrin. Our data suggest that deltamethrin resistance was mediated by P450 enzymes, since bioassays with synergists showed that PBO reverted resistance in a field population and the laboratory strains, whereas the effect of DEF and DEM was minor and no mutations were found in the VGSC gene. The inheritance of resistance for both strains was completely recessive, autosomic and did not fit the mortality expected for a recessive character under a monogenic or digenic model. We also found that deltamethrin resistance presented a fitness cost in terms of males’ weight, males’ and females’ longevity and lifetime fecundity, with a more pronounced effect in the BP-strain than in the Rfg-delta strain. Our results highlight the need to implement insecticide resistance management strategies to prevent control failures.
Monitoring the role of soil hydrologic conditions and rainfall for the triggering of torrential flows in the Rebaixader catchment (Central Pyrenees, Spain)
Authors: Oorthuis Raül , Hürlimann Marcel , Vaunat Jean , Moya José , Lloret Antonio 
Published: November 2022

Abstract
Torrential flows (debris flows and debris floods) are mainly triggered by precipitation and soil hydrological processes. Most early warning systems in torrential catchments are rainfall-based. However, this approach can result in frequent false positives, due to its pure black-box nature, in which soil water conditions are neglected. We aim to contribute to the understanding of the conditions required for triggering torrential flows by considering also in situ measurements of soil water content. Herein, monitoring data of 12 years of rainfall and torrential flow occurrence (2009–2020) and 8 years of soil hydrologic conditions (2013–2020) in the Rebaixader catchment (Central Pyrenees, Spain) are analyzed. The dataset includes more than 1000 rainfall events and 37 torrential flows. First, rainfall thresholds using maximum rainfall intensity (Imax) and mean intensity (Imean) are defined. For the 2013–2020 dataset, which includes 15 torrential events, the Imean threshold predicted 2 false negatives and 73 false positives (positive predictive value, PPV, of 15.1%) and the best Imax threshold predicted also 2 false negatives but only 11 false positives (PPV of 54.2%). However, our observations confirmed quantitatively that the lower is the soil moisture the higher is the rainfall intensity to trigger torrential flows. Then, we combined Imax and volumetric water content at 15 and 30 cm depth to define a hydro-meteorological threshold. This latter threshold reduced false negatives to 1 and false positives to 8 and increased the PPV to 63.6%. These results confirm that soil hydrological conditions are key factors for torrential flow triggering and may improve early-warning predictions.
Geotechnical reconnaissance findings of the October 30 2020, Mw7.0 Samos Island (Aegean Sea) earthquake
Authors: Ziotopoulou Katerina , Cetin Kemal Onder , Pelekis Panagiotis , Altun Selim , Klimis Nikolaos , Sezer Alper , Rovithis Emmanouil , Yılmaz Mustafa Tolga , Papadimitriou Achilleas G. , Gulerce Zeynep , Can Gizem , Ilgac Makbule , Cakır Elife , Soylemez Berkan , Al-Suhaily Ahmed , Elsaid Alaa , Zarzour Moutasem , Ecemis Nurhan , Unutmaz Berna , Kockar Mustafa Kerem , Akgun Mustafa , Kincal Cem , Bayat Ece Eseller , Ozener Pelin Tohumcu , Stewart Jonathan P. , Mylonakis George 
Published: November 2022

AbstractOn October 30, 2020 14:51 (UTC), a moment magnitude (Mw) of 7.0 (USGS, EMSC) earthquake occurred in the Aegean Sea north of the island of Samos, Greece. Turkish and Hellenic geotechnical reconnaissance teams were deployed immediately after the event and their findings are documented herein. The predominantly observed failure mechanism was that of earthquake-induced liquefaction and its associated impacts. Such failures are presented and discussed together with a preliminary assessment of the performance of building foundations, slopes and deep excavations, retaining structures and quay walls. On the Anatolian side (Turkey), and with the exception of the Izmir-Bayrakli region where significant site effects were observed, no major geotechnical effects were observed in the form of foundation failures, surface manifestation of liquefaction and lateral soil spreading, rock falls/landslides, failures of deep excavations, retaining structures, quay walls, and subway tunnels. In Samos (Greece), evidence of liquefaction, lateral spreading and damage to quay walls in ports were observed on the northern side of the island. Despite the proximity to the fault (about 10 km), the amplitude and the duration of shaking, the associated liquefaction phenomena were not pervasive. It is further unclear whether the damage to quay walls was due to liquefaction of the underlying soil, or merely due to the inertia of those structures, in conjunction with the presence of soft (yet not necessarily liquefied) foundation soil. A number of rockfalls/landslides were observed but the relevant phenomena were not particularly severe. Similar to the Anatolian side, no failures of engineered retaining structures and major infrastructure such as dams, bridges, viaducts, tunnels were observed in the island of Samos which can be mostly attributed to the lack of such infrastructure.
Innovative Ground Improvement with Chemical Grouts: Potential and Limits of Partial Saturation with Polymers
Authors: Pratter Paul , Boley Conrad , Forouzandeh Yashar 
Published: November 2022

AbstractNowadays, polymers are well-established in geotechnical applications, for example as grouting material for soil and rock stabilization, or as grouting material for anchorages. Concerning ground improvement, the polymers act as a binder that, if cured, holds the grains together by adhesive and cohesive forces. This special characteristic enables the use of less material and therefore saves costs but requires detailed knowledge of the material behavior to avoid application errors. The subject of this research work are two different polymers, which are used for partial saturation of the ground. For the investigation of the mechanical and hydraulic properties of the ground improvement, the geotechnical testing program on the composite material of polymers and gravel is extended by special tests, such as rheometer tests, for chemical grouts. If the polymers are used correctly, the composite material can achieve a load-bearing capacity comparable to that of concrete while the material remaining permeable. This is highlighted by strength tests on the composite material. Finally, the numerical calculation of a track ballast stabilization, using PFC-FLAC3D coupling, demonstrates the potential of the polymers for practical application and that even difficult ground conditions can be handled with it.
The Final Cut
Authors: Zardini Elia 
Published: November 2022

AbstractIn a series of works, Pablo Cobreros, Paul Égré, David Ripley and Robert van Rooij have proposed a nontransitive system (call it ‘K3LP’) as a basis for a solution to the semantic paradoxes. I critically consider that proposal at three levels. At the level of the background logic, I present a conception of classical logic on which K3LP fails to vindicate classical logic not only in terms of structural principles, but also in terms of operational ones. At the level of the theory of truth, I raise a cluster of philosophical difficulties for a K3LP-based system of naive truth, all variously related to the fact that such a system proves things that would seem already by themselves repugnant, even in the absence of transitivity. At the level of the theory of validity, I consider an extension of the K3LP-based system of naive validity that is supposed to certify that validity in that system does not fall short of naive validity, argue that such an extension is untenable in that its nontriviality depends on the inadmissibility of a certain irresistible instance of transitivity (whence the advertised “final cut”) and conclude on this basis that the K3LP-based system of naive validity cannot coherently be adopted either. At all these levels, a crucial role is played by certain metaentailments and by the extra strength they afford over the corresponding entailments: on the one hand, such strength derives from considerations that would seem just as compelling in a general nontransitive framework, but, on the other hand, such strength wreaks havoc in the particular setting of K3LP.