bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building Occupancy Simulation and Analysis under Virus Scenarios
Authors: Sydora Christoph , Nawaz Faiza , Bindra Leepakshi , Stroulia Eleni 
Published: January 2022

During the COVID-19 pandemic, regulations on building usage and occupancy density were brought to the forefront, as research indicated that transmission was most likely to occur in indoor environments. Public health officials and building managers had to decide how to best use their buildings while curtailing the infection risk for their occupants.
In this article, we present a systematic simulation-based methodology for estimating the infection risk for a building’s occupants under different scenarios of building usage. We have evaluated our simulations against some real-world building usage data from a university campus building; our experiments demonstrate the realism of our simulations. Based on this finding, we have developed a virus transmission model that estimates the potential infection transmission risk given the behaviors of a building’s occupants. Our methodology enables building managers to simulate alternative building usage scenarios and estimate their relative infection transmission risk. We argue that such risk estimate comparisons can be useful in making decision about alternative building usage options.
L’opera (pseudo) galenica De hirudinibus, revulsione, cucurbitula, incisione et scarificatione
Authors: Ecca Giulia 
Published: January 2022

Abstract
The work entitled De hirudinibus, revulsione, cucurbitula, incisione et scarificatione is composed of four different texts and has been attributed to Galen of Pergamum in the manuscript tradition. A new analysis of this work sheds light on striking parallels with passages of important encyclopedists from late antiquity, like Oribasius of Pergamum and Aetius. This comparison demonstrates that with all probability the work is the result of a late antique selection of texts ascribed to Galen.
Toward Experimental Heat–Health Early Warning in Africa
Authors: Thiaw Wassila M. , Bekele Endalkachew , Diouf Sarah N. , Dewitt David G. , Ndiaye Ousmane , Ngom Ndiaye Marie Khemesse , Ndiaye Papa Ngor , Diene Nar , Diouf Mariama , Diaw Anta , Diop Siga , Badj Fanding , Diouf Abdoulaye 
Published: January 2022

Abstract
Heat is one of the most serious hazards in the world as it affects human health and is extremely dangerous to vulnerable populations such as the elderly, people with preexisting cardiovascular or respiratory conditions, and even healthy people with prolonged sunlight exposure during heat waves. As the globe has warmed over the past several decades, extreme heat has become more frequent and intense than ever before, and Africa, especially the Sahel in West Africa, is one of the regions of the world where heat is a major public health concern exacerbated by livelihood activities during the heat season. Yet, there is a major gap in monitoring and forecasting heat waves in Africa. This paper describes NOAA’s role in enabling heat–health early warning in Africa, working with meteorological services and health professionals. Emphasis is on real-time heat wave forecasting at week 2, including the postprocessing of the NCEP model outputs, and providing the information to the meteorological services in Africa to serve as guidance in national heat wave forecasts. In addition, the paper describes the end-to-end process of heat hazard outlooks and translating the forecasts into early action and early planning to reduce heat risk to human health. Furthermore, the paper addresses the very important aspect of capacity development tailored at enhancing forecasters’ skills to prepare and issue heat wave forecasts and training of a cadre of health professionals to work with meteorologists to coproduce heat–health bulletins and to issue heat–health early warnings.
The COVID-19 Pandemic and Access to Selected Ambulatory Care Services Among Populations With Severely Uncontrolled Diabetes and Hypertension in Massachusetts
Authors: Nielsen Victoria M. , Song Glory , Ojamaa Lea Susan , Blodgett Ruth P. , Rocchio Catherine M. , Pennock Jena N. 
Published: January 2022

Objectives: The outbreak of COVID-19 in Massachusetts may have reduced ambulatory care access. Our study aimed to quantify this impact among populations with severely uncontrolled diabetes and hypertension; these populations are at greatest risk for adverse outcomes caused by disruptions in care. Methods: We analyzed multidisciplinary ambulatory electronic health record data from MDPHnet. We established 3 cohorts of patients with severely uncontrolled diabetes and 3 cohorts of patients with severely uncontrolled hypertension using 2017, 2018, and 2019 data, then followed each cohort through the subsequent 15 months. For the diabetes cohorts, we generated quarterly counts of glycated hemoglobin A1c (HbA1c) tests. For the hypertension cohorts, we generated monthly counts of blood pressure measurements. Finally, we assessed telehealth use among the 2019 diabetes and hypertension cohorts from January 2020 through March 2021. Results: HbA1c testing and blood pressure monitoring dropped considerably during the pandemic compared with previous years. In the 2019 diabetes cohort, HbA1c measurements declined from 44.0% in January–March 2020 (baseline) to 15.9% in April–June 2020 and was 11.8 percentage points below baseline in January–March 2021. In the 2019 hypertension cohort, blood pressure measurements declined from 40.0% in January 2020 to 4.5% in April 2020 and was 23.5 percentage points below baseline in March 2021. Telehealth use increased precipitously during the pandemic but was not uniform across subpopulations. Conclusions: Access to selected diabetes and hypertension services declined sharply during the pandemic among populations with severely uncontrolled disease. Although telehealth is an important strategy, ensuring equity in access is essential. Telehealth hybrid models can also minimize disruptions in care.
Association between interleukin 12B and interleukin 23R gene polymorphisms and systemic lupus erythematosus: a meta-analysis
Authors: Jung Jae Hyun , Lim Ji Hyun , Song Gwan Gyu , Kim Bo Young 
Published: January 2022

Objective To determine whether polymorphisms of interleukin 12B ( IL12B) and IL23 receptor genes ( IL23R) confer susceptibility to systemic lupus erythematosus (SLE). Methods A meta-analysis was conducted to analyze the associations between SLE and IL12B rs3212227 and rs17860508 and IL23R rs7517847, rs10489629, rs10889677, rs1004819, rs11209026, rs11209032, rs1343151, and rs1884444 polymorphisms using allele contrast, dominant, recessive, heterozygote, and homozygote models. Ten studies involving 1989 patients with SLE and 2394 controls were considered for the meta-analysis. Results The meta-analysis using the homozygote model revealed that IL23R rs10889677 was significantly associated with SLE susceptibility in the overall population (AA vs. CC) (odds ratio = 0.70, 95% confidence interval = 0.50–0.98) but not in the Asian population. Other polymorphisms of IL12B and IL23R were not significantly associated with SLE protection. Conclusions These findings suggest that the IL23R rs10889677 polymorphism confers SLE susceptibility to individuals of certain ethnicities. (Research Registry number: 1268)
Childhood Sexual Abuse, Dyadic Empathy, and Intimate Partner Violence Among Men Seeking Psychological Help
Authors: Brassard Audrey , Charbachi Noëlle , Claing Aurélie , Godbout Natacha , Savard Claudia , Lafontaine Marie-France , Péloquin Katherine 
Published: January 2022

Childhood sexual abuse (CSA) and intimate partner violence (IPV) have both been associated with numerous negative repercussions. The first aim of this study is to understand IPV perpetrated by men within a clinical population, by examining the effects of two potential predictors: CSA and dyadic empathy (cognitive and emotional). The second aim of this study is to explore whether dyadic empathy is an intermediary variable of the association between CSA and IPV. A sample of 198 men (aged 18–69 years old) who were seeking help for relationship problems, completed a set of self-administered questionnaires. While controlling for social desirability and family violence history, our findings outlined the mediating and moderating role of dyadic empathy in the link between CSA and perpetrated psychological, but not physical, IPV. Emotional empathy mediated and moderated the link between CSA and psychological IPV, whereas cognitive empathy only moderated this link. The examination of the direct links between the variables also revealed that CSA was related to lower emotional empathy and higher rates of both types of IPV. In addition, cognitive empathy was negatively associated with physical and psychological IPV, whereas emotional empathy was positively associated with psychological IPV. This study contributes to the literature by documenting some of the mechanisms that could explain the perpetration of IPV and highlights the importance of investigating CSA and empathy in men who are seeking help.
In good times and in bad: A longitudinal analysis of the impact of bereavement on self-esteem and life satisfaction in couples
Authors: Reitz Anne K. , Weidmann Rebekka , Wünsche Jenna , Bühler Janina L. , Burriss Robert P. , Grob Alexander 
Published: January 2022

This study examines the impact of bereavement on self-esteem and life satisfaction in both partners of a romantic couple. We investigate the moderating effects of the type of the lost relationship (close family, close friends/others) and romantic relationship characteristics (daily social support, responsiveness-closeness, self-disclosure). We examined 1238 individuals in 619 male–female couples from the ages 18 to 81 ( M [ SD] = 31.97 years [13.26]). Both partners completed questionnaires at two assessments that were 20 months ( SD = 2.02 months) apart, in between which n = 216 individuals were bereaved. Actor–partner interdependence models showed that bereavement did not predict later self-esteem or life satisfaction in either of the partners. The relationship characteristics and the type of lost relationship did not moderate the effects. The subjective meaning and distress of the loss predicted later self-esteem and life satisfaction. The self-esteem increase was larger for bereaved with a positive/neutral than for bereaved with a negative meaning of the bereavement. We found a partner effect on self-esteem for the group of bereaved who reported a negative meaning of the bereavement. The findings demonstrate that bereavement can impact romantic partners' self-esteem and that the subjective experience of bereavement helps understand individual differences in the effect of bereavement on self-esteem and life satisfaction.
Genetic screening of early-onset patients with systemic lupus erythematosus by a targeted next-generation sequencing gene panel
Authors: Dasdemir Selcuk , Yildiz Mehmet , Celebi Damla , Sahin Sezgin , Aliyeva Numune , Haslak Fatih , Gunalp Aybuke , Adrovic Amra , Barut Kenan , Artim Esen Bahar , Kasapcopur Ozgur 
Published: January 2022

Objective In this study, we aimed to screen 31 genes (C1QA, C1QB, C1QC, C1R, C1S, C2, C3, TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, DNASE1, DNASE1L3, PRKCD, ACP5, SLC7A7, IFIH1, TMEM173, ISG15, CYBB, FAS, FASLG, KRAS, NRAS, MAN2B1, PEPD, PTPN11, RAG2, and SHOC2), that we have categorized under the umbrella term “monogenic lupus” using a targeted next-generation sequencing (NGS) panel in 24 individuals with early-onset (≤10 years of age) systemic lupus erythematosus (SLE) and in 24 patients with late-onset (>10 years of age) disease. Methods A total of 48 SLE patients (24 with disease onset ≤10 years of age and 24 with disease onset >10 years of age) were included. Patients with late-onset disease have been used as patient controls. Sequencing was carried out using 400 bp kit on the Ion S5 system. Results Among the 48 patients, three had one pathogenic variant and 45 patients had at least one rare variant classified as benign, likely benign or variant of unknown significance (VUS). In all three patients with a pathogenic variant, the onset of disease was before 10 years of age. Two patients (they were siblings) carried C1QA homozygote pathogenic allele (p.Gln208Ter, rs121909581), and one patient carried PEPD heterozygote pathogenic allele (p.Arg184Gln, rs121917722). Conclusion We demonstrated a pathogenic variant in our target gene panel with a frequency of 9.52% in patients with a disease onset ≤10 years of age. All patients with early-onset SLE phenotype, irrespective of a positive family history for SLE or parental consanguinity, should be scanned for a single-gene defect by a targeted gene panel sequencing. With the discovery of many single-gene defects and ongoing efforts to identify novel genes in SLE, similar gene panels including even more genes will possibly become more necessary and practical in the future.
Early Palliative Care in Patients With Non–Small-Cell Lung Cancer: A Randomized Controlled Trial in Southwest China
Authors: Chen Mengting , Yang Liejun , Yu Huiqing , Yu Huijuan , Wang Sixiong , Tian Ling , Liu Shihong 
Published: January 2022

Purpose: Effective interventions to improve prognosis in non–small-cell lung cancer (NSCLC) are urgently needed. We assessed the effect of the early integration of interdisciplinary palliative care (based on WARM model) for patients with NSCLC on the quality of life (QoL), psychological state, cancer pain and nutritional status. Methods: In this randomized controlled trial, 120 newly diagnosed NSCLC patients were enrolled and randomly assigned (1:1) to the combined early palliative care (CEPC) group integrated with standard oncologic care or standard oncological care (SC) group. QoL and psychological state were assessed at baseline and at 24 weeks by Functional Assessment of Cancer Therapy-Lung (FACT-L) scale, the Hospital Anxiety and Depression Scale (HADS) and Patient Health Questionnaire-9 (PHQ-9), respectively. Cancer nutritional and pain status were assessed with the use of the Patient-Generated Subjective Global Assessment (PG-SGA) and Numerical Rating Scale (NRS), respectively. The primary outcome was the change in the quality of life, psychological state and nutritional status at 24 weeks. Analysis was by intention to treat. Results: 120 patients were enrolled: 60 in CEPC group (38 completed) and 60 in the SC group (32 completed). CEPC group had a better QoL than SC group ( P < .05). In addition, fewer patients in the CEPC group than in the SC group had depressive ( P = .005) symptoms. Furthermore, patients in CEPC group had a better nutritional status than SC group ( P = .001). Conclusion: Among patients with non–small-cell lung cancer, early palliative care led to significant improvements in quality of life, psychological state and nutritional status.
Papilledema and idiopathic intracranial hypertension due to the possible potentiation of ATRA by posaconazole in a case of acute promyelocytic leukemia
Authors: Atas Unal , Aydin Ersoy Merve , Iltar Utku , Yucel Orhan Kemal , Turkoglu Elif Betul , Salim Ozan 
Published: January 2022

Introduction Idiopathic intracranial hypertension (IIH) (pseudotumor cerebri) is a rare side effect of all-trans retinoic acid (ATRA). IIH cases have been observed after the concomitant use of ATRA with azole group antimicrobials such as fluconazole and voriconazole. Here, we discuss about the diagnosis and treatment process of the IIH emerging in a young acute promyelocytic leukemia (APL) case with the ATRA impact, which can be increased by posaconazole. Case A 19-year-old male patient was diagnosed with APL. Headache and blurred vision were developed on the 12th day of the AIDA (ATRA, 45 mg/m2/day, oral and idarubicin 12 mg/m2, on days 2, 4, 6, 8, intravenous) protocol and posaconazole proflaxis. He was diagnosed IIH along with the existing eye findings and imagings. Management & Outcome ATRA treatment and posaconazole were interrupted. Systemic acetazolamide and dexamethasone treatment were initiated. After significant clinical response was observed, ATRA treatment was resumed without posaconazole and a similar clinical condition did not recur. Discussion The combined use of ATRA and azole group drugs increases the risk of developing IIH. Patients with APL who developed IIH during the concomitant use of ATRA and fluconazole or voriconazole have been reported. To the best of our knowledge, our case is the first APL case with a IIH who treated with ATRA-based therapy and used posaconazole. In case of development of side effects, drugs should be interrupted and this combination should be avoided if possible after appropriate approach and clinical improvement.
Duration of sweat cyclophosphamide excretion in patients undergoing a conditioning regimen of high-dose cyclophosphamide for hematopoietic stem-cell transplantation
Authors: Tanigawa Hiromu , Hirohara Masayoshi , Marutani Yoshinori , Suzuki Yuji , Onizuka Makoto , Oda Shiori , Orita Mutsuko , Sato Masayo , Kushida Kazuki 
Published: January 2022

Purpose To investigate the duration of cyclophosphamide (CPA) excretion in the sweat after administration when receiving high-dose CPA therapy as a conditioning regimen for hematopoietic stem-cell transplantation (HSCT). Methods Shirts and pillowcases samples (changed once a day) from 12 patients, categorized as groups 1 (n  =  6), 2 (n = 4), and 3 (n  =  2), receiving high-dose CPA therapy were collected, sealed, stored at 4°C, and mailed to an analytical facility for CPA estimation using LC-MS/MS. CPA was administered intravenously at a dose of 60 mg/kg on days 1, 2 (closed-system delivery for group 3), and samples were collected during days 1–4 (groups 1,3) or days 1–9 (group 2). Results CPA was detected in all 126 shirts and pillowcases. In 9 patients, excluding 1 patient who had fever during the study period and group 3 patients, the mean (range) rate of CPA excretion in sweat was 0.03% (0.01–0.12%). The mean CPA excretion in 9 patients adjusted for body weight was 19.9 μg/kg on day 1 and 0.3 μg/kg on day 4. Conclusions This study showed that CPA was excreted for an extended duration in the patient's sweat, receiving a high-dose CPA therapy as a conditioning regimen against HSCT.
The effect of atropine used in dobutamine stress echocardiography on pupil diameter
Authors: Soulis Dimitrios , Papaioannou Theodore G , Zozolou Maria , Daskalopoulou Stella , Vlachopoulos Charalampos , Bethanis Dimitrios , Triantafyllou Dimitrios 
Published: January 2022

Background The use of atropine during dobutamine stress echocardiography (DSE) is contraindicated in persons with narrow angle glaucoma though there is limited evidence that low doses of intravenous atropine do not cause pupillary dilation. Objective The aim of this study is to investigate whether atropine when administered in persons without glaucoma during dobutamine stress echocardiography causes pupillary dilation. Methods and Results Out of 144 patients without a history of glaucoma referred for DSE for clinical indications, 105 patients received intravenous atropine doses ranging from 0.1 mg to 1.25 mg (most patients received 0.25–0.75 mg). Pupil diameter of both eyes was measured under the same light conditions before and after the DSE using a CP-30 Optical Digital PD Ruler. For the total of 210 examined eyes pupil diameter remained unaltered after each DSE test (3.65 ± 0.799 mm before vs 3.63 ± 0.766 mm after, p = .737). Similarly, pupil diameter remained unchanged when left and right eyes were assessed separately (right eye: 3.770 ± 0.812 before vs 3.752 ± 0.745 mm after, p = .821 and left eye: 3.521 ± 0.770 before vs 3.499 ± 0.770 mm after, p = .806). Diameter of right and left pupil were also unaltered after grouping patients by sex and iris pigmentation. Age, weight, atropine dose and propranolol dose were not correlated with changes in pupil diameter. Conclusion Intravenous atropine in usual doses administered in DSE does not cause mydriasis in adults without glaucoma. Future studies need to confirm our findings and expand the investigation regarding safety of atropine use during DSE in patients with narrow angle glaucoma.
Village health worker motivation for better performance in a maternal and child health programme in Nigeria: A realist evaluation
Authors: Mbachu Chinyere , Etiaba Enyi , Ebenso Bassey , Ogu Udochukwu , Onwujekwe Obinna , Uzochukwu Benjamin , Manzano Ana , Mirzoev Tolib 
Published: January 2022

Background Community health workers play an important role in linking communities with formal health service providers, thereby improving access to and utilization of health care. A novel cadre of community health workers known as village health workers (VHWs) were recruited to create demand for maternal health services in the Nigerian Subsidy Reinvestment Programme (SURE-P/MCH). In this study, we investigated the role of contextual factors and underlying mechanisms motivating VHWs. Methods We used realist evaluation to understand the impact of a multi-intervention maternal and child health programme on VHW motivation using Anambra State as a case study. Initial working theories and logic maps were developed through literature review and stakeholder engagement; programme theories were developed and tested using focus group discussions and in-depth interviews with various stakeholder groups. Interview transcripts were analysed through an integrated approach of Context, Mechanism and Outcomes (CMO) categorisation and connecting, and matching of patterns of CMO configurations. Motivation theories were used to explain factors that influence VHW motivation. Explanatory configurations are reported in line with RAMESES reporting standards. Results The performance of VHWs in the SURE-P maternal and child health programme was linked to four main mechanisms of motivation: feelings of confidence, sense of identity or feeling of acceptance, feeling of happiness and hopefulness/expectation of valued outcome. These mechanisms were triggered by interactions of programme-specific contexts and resources such as training and supervision of VHWs by skilled health workers, provision of first aid kits and uniforms, and payments of a monthly stipend. The monthly payment was considered to be the most important motivational factor by VHWs. VHWs used a combination of innovative approaches to create demand for maternity services among pregnant women, and their performance was influenced by health system factors such as organisational capacity and culture, and societal factors such as relationship with the community and community support. Conclusion This paper highlights important contextual factors and mechanisms for VHW motivation that can be applied to other interventions that seek to strengthen community engagement and demand creation in primary health care. Future research on how to sustain VHW motivation is also required.