bluuebunny/crossref_metadata_2025_split huggingface dataset:
Residual Closeness, Matching Number and Chromatic Number
Authors: Wang Yanna , Zhou Bo 
Published: January 2022

Abstract
Residual closeness is a novel graph-based network vulnerability parameter. In this model, links are perfectly reliable and the nodes fail independently of each other. We characterize those graphs with maximum residual closeness and those connected graphs with minimum residual closeness when matching number (chromatic number, respectively) is fixed.
Sorry not Sorry: (Non-) Apology, Satire, and the Vacuum
Authors: McEvoy Tara 
Published: January 2022

Abstract
This essay considers the theme of apology and what happens when the demand for apology is subverted, using the Vacuum newspaper as a case study. I consider the argument that played out in 2004 between the Vacuum and Belfast City Council, which partially funded its production. The Vacuum’s publication of themed double issues entitled ‘God’ and ‘Satan’ provoked the ire of conservative Council Members who proposed that the publication's editors must apologize to Members of the Council and the citizens of Belfast for the offence they had caused. In so doing, the publication secured its place as one of the most controversial Northern Irish print publications of recent years.
In their response to the Council’s demand – a themed ‘Sorry’ issue – the Vacuum’s editors struck a defiant tone. Media discourse around the ‘Sorry’ issue of the Vacuum has centred on the element of public spectacle it generated, but this essay represents a reconsideration of its importance. I read it as informed by an ethics of resistance. By refusing to be co-opted into making a sham apology, the ‘Sorry’ issue illuminates the crucial importance of apology in the place and time of its production – in a country still reeling from the violence of the Troubles.
Macroeconomic dynamics and reallocation in an epidemic: evaluating the ‘Swedish solution’
Authors: Krueger Dirk , Uhlig Harald , Xie Taojun 
Published: January 2022

Abstract
In this paper, we argue that endogenous shifts in private consumption behaviour across sectors of the economy can act as a potent mitigation mechanism during an epidemic or when the economy is re-opened after a temporary lockdown. We introduce a susceptible-infected-recovered epidemiological model into a neoclassical production economy in which goods are distinguished by the degree to which they can be consumed at home rather than in a social, possibly contagious context. We demonstrate within the model, that the ‘Swedish solution’ of letting the epidemic play out without much government intervention and allowing agents to reduce their overall consumption as well as shift their consumption behaviour towards relatively safe sectors can lead to substantial mitigation of the economic and human costs of the COVID-19 crisis. We argue that significant seasonal variation in the infection risk is needed to account for the two-wave nature of the pandemic. We estimate the model on Swedish health data and show that it predicts the dynamics of weekly deaths, aggregate as well as sectoral consumption, that accord well with the empirical record and the two-waves for Sweden for 2020 and early 2021. We also characterize the allocation a social planner would choose and how it would dictate sectoral consumption patterns. In so doing, we demonstrate that the laissez-faire outcome with sectoral reallocation mitigates the economic and health crisis but possibly at the expense of unnecessary deaths and too massive a decline in economic activity.
Association Between Mediterranean Diet and Functional Status in Older Adults: A Longitudinal Study Based on the Washington Heights–Inwood Columbia Aging Project
Authors: Guo Jing , Schupf Nicole , Cruz Emily , Stern Yaakov , Mayeux Richard P , Gu Yian 
Published: January 2022

AbstractBackgroundCurrent evidence on the association between Mediterranean diet (MeDi) intake and activities of daily living (ADL) is limited and inconsistent in older adults.MethodsThis study included 1 696 participants aged ≥65 years in the Washington Heights–Inwood Community Aging Project study. The MeDi score was calculated based on data collected from the Willett’s semiquantitative food frequency questionnaire. The multivariable-adjusted Cox regression model was applied to examine the association of MeDi score with risks of disability in basic (BADL) and instrumental ADL (IADL), as well as the overall ADL (B-IADL).ResultsEight hundred and thirty-two participants with incident ADL disability were identified over a median follow-up of 5.39 years. The continuous MeDi score was significantly associated with decreased risk of disability in B-IADL (hazard ratio = 0.95, 95% confidence interval = 0.91–0.99, p = .018) in a model adjusted for age, sex, race/ethnicity, educational level, and dietary calories intake but was no longer significant after additionally adjusted for multiple comorbidities and physical activities (0.97 [0.93, 1.01], p = .121). The continuous MeDi score was significantly associated with decreased risk of disability in B-IADL (0.92 [0.85, 1.00], p = .043) and BADL (0.90 [0.82, 0.99], p = .030) in non-Hispanic Whites, but not in non-Hispanic Blacks and Hispanics (p &gt; .05 for all).ConclusionsHigher MeDi score was associated with decreased risk of ADL disability, particularly in non-Hispanic Whites.
Prospective evaluation of multiplicative hybrid earthquake forecasting models in California
Authors: Bayona J A , Savran W H , Rhoades D A , Werner M J 
Published: January 2022

SUMMARYThe Regional Earthquake Likelihood Models (RELM) experiment, conducted within the Collaboratory for the Study of Earthquake Predictability (CSEP), showed that the smoothed seismicity (HKJ) model by Helmstetter et al. was the most informative time-independent earthquake model in California during the 2006–2010 evaluation period. The diversity of competing forecast hypotheses and geophysical data sets used in RELM was suitable for combining multiple models that could provide more informative earthquake forecasts than HKJ. Thus, Rhoades et al. created multiplicative hybrid models that involve the HKJ model as a baseline and one or more conjugate models. In retrospective evaluations, some hybrid models showed significant information gains over the HKJ forecast. Here, we prospectively assess the predictive skills of 16 hybrids and 6 original RELM forecasts at a 0.05 significance level, using a suite of traditional and new CSEP tests that rely on a Poisson and a binary likelihood function. In addition, we include consistency test results at a Bonferroni-adjusted significance level of 0.025 to address the problem of multiple tests. Furthermore, we compare the performance of each forecast to that of HKJ. The evaluation data set contains 40 target events recorded within the CSEP California testing region from 2011 January 1 to 2020 December 31, including the 2016 Hawthorne earthquake swarm in southwestern Nevada and the 2019 Ridgecrest sequence. Consistency test results show that most forecasting models overestimate the number of earthquakes and struggle to explain the spatial distribution of epicenters, especially in the case of seismicity clusters. The binary likelihood function significantly reduces the sensitivity of spatial log-likelihood scores to clustering, however; most models still fail to adequately describe spatial earthquake patterns. Contrary to retrospective analyses, our prospective test results show that none of the models are significantly more informative than the HKJ benchmark forecast, which we interpret to be due to temporal instabilities in the fit that forms hybrids. These results suggest that smoothing high-resolution, small earthquake data remains a robust method for forecasting moderate-to-large earthquakes over a period of 5–15 yr in California.
On Semisimplicity of Jantzen Middles for the Periplectic Lie Superalgebra
Authors: Chen Chih-Whi 
Published: January 2022

AbstractWe prove that an integral block of the category $\mathcal O$ of the periplectic Lie superalgebra contains a non-semisimple Jantzen middle if and only if it contains a simple module of atypical highest weight. As a consequence, every atypical integral block of $\mathcal O$ does not admit a Kazhdan–Lusztig theory in the sense of Cline, Parshall, and Scott.
Survey of infectious diseases providers reveals variability in duration of antibiotic therapy for the treatment of Gram-negative bloodstream infections
Authors: Thaden Joshua T. , Tamma Pranita D. , Pan Qing , Doi Yohei , Daneman Nick 
Published: January 2022

Abstract

Background
Trials supporting shorter durations of antibiotic therapy for Gram-negative bloodstream infections (GN-BSI) have recently been published. However, adoption of these findings into practice is unclear given limited eligibility criteria and relatively large non-inferiority margins of these studies. To better understand contemporary management of GN-BSI, we conducted an international survey of infectious diseases (ID) specialists.

Methods
We developed and disseminated an online survey to assess practice patterns involving treatment duration of GN-BSI, including providers from 28 countries. χ2 tests, t-tests and multivariable linear regression with generalized estimating equations were used to identify factors associated with treatment duration.

Results
In total, 277 ID specialists completed the survey (64% physicians, 31% pharmacists). The median reported duration of antibiotics was 7 days (IQR, 7–10 days) for all GN-BSI sources. Thirty percent of providers typically recommend durations that differ by ≥7 days depending on the source of GN-BSI, and 71% treat ≥10 days for at least one source. In an adjusted model, factors associated with increased duration included intra-abdominal (+1.01 days, 95% CI 0.57–1.45 days; P &lt; 0.0001), vascular catheter (+0.74 days; 0.33–1.15 days; P = 0.0004), and respiratory (+0.76 days; 0.38–1.14 days; P &lt; 0.0001) sources of GN-BSI relative to urinary sources. Providers that transition patients to oral therapy report shorter durations than those who treat with full IV therapy (−0.60 days; −1.12 to −0.09 days; P = 0.02).

Conclusions
There is extensive heterogeneity in duration of therapy for treating GN-BSI, particularly with respect to source of GN-BSI. Investigations into appropriate treatment durations for different GN-BSI sources are needed.
Management of elderly patients with advanced cutaneous squamous cell carcinoma
Authors: Maeda Takuya , Yoshino Koji 
Published: January 2022

Abstract
The incidence of cutaneous squamous cell carcinoma has been increasing rapidly in recent years, especially among the elderly. The purpose of this review article is to summarize the findings of studies on systemic therapy for advanced cutaneous squamous cell carcinoma, to review geriatric screening tools, which can assess frailty and predict treatment outcomes, and discuss the indications of their use in advanced cases. A literature review revealed that studies on systemic therapy for advanced cutaneous squamous cell carcinoma often included relatively older patients. However, there has been little research on the safety and efficacy of systemic therapy for advanced disease that takes older age and frailty into account. Notably, studies on geriatric screening for skin cancer have been conducted in recent years, mainly to detect early-stage resectable cases. The Geriatric 8 screening tool is considered the most useful for predicting post-operative complications in patients with early-stage cancer, as it can evaluate comorbidities, polypharmacy and cognition, has appropriate measurement properties, can be quickly executed and is clinically relevant, easily understandable and interpretable. This geriatric screening tool may also be applicable in advanced-stage cancer. In conclusion, despite the fact that advanced cutaneous squamous cell carcinoma occurs mainly in the elderly, the importance of geriatric screening has not yet been fully appreciated by dermato-oncologists. In the future, geriatric screening tools should be actively used in clinical trials for the appropriate assessment of drug efficacy and toxicity in elderly patients with advanced cutaneous squamous cell carcinoma.
Systemic therapy for salivary gland malignancy: current status and future perspectives
Authors: Imamura Yoshinori , Kiyota Naomi , Tahara Makoto , Hanai Nobuhiro , Asakage Takahiro , Matsuura Kazuto , Ota Ichiro , Saito Yuki , Sano Daisuke , Kodaira Takeshi , Motegi Atsushi , Yasuda Koichi , Takahashi Shunji , Yokota Tomoya , Okano Susumu , Tanaka Kaoru , Onoe Takuma , Ariizumi Yosuke , Homma Akihiro 
Published: January 2022

Abstract
Salivary gland malignancies are rare neoplasms that have a broad histological spectrum and a variety of biologic behaviors. Salivary gland malignancies are known as chemo-resistant tumors, which render optimal treatment challenging. This review summarizes the role of systemic therapy for salivary gland malignancies. To date, the advantage of adding concurrent chemotherapy has remained undefined for both postoperative and inoperable locally advanced salivary gland malignancy patients undergoing radiotherapy. For recurrent/metastatic disease, local and/or systemic treatment options should be discussed in a multidisciplinary setting with consideration to both patient needs and tumor factors. For symptomatic patients or those who may compromise organ function, palliative systemic therapy can be a reasonable option based on the results of phase II studies. Platinum combination regimens as first-line therapy have been widely accepted. Personalized therapies have become established options, particularly for androgen receptor-positive, HER2-positive and NTRK fusion-positive salivary gland malignancies (i.e. androgen receptor and HER2 in salivary duct carcinoma and NTRK3 in secretory carcinoma). For patients with adenoid cystic carcinoma, multi-targeted tyrosine kinase inhibitors have also been developed. Anti-PD1 checkpoint inhibitors have shown limited activity to date. Investigation of active systemic treatments for salivary gland malignancy remains a significant unmet need. Future directions might include a more comprehensive genomic screening approach (usually next-generation sequencing-based) and combination strategies using immune checkpoint inhibitors. These are rare malignancies that require ongoing effort in the conduct of high-quality clinical trials.
Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis
Authors: Murphy Neil , Song Mingyang , Papadimitriou Nikos , Carreras-Torres Robert , Langenberg Claudia , Martin Richard M , Tsilidis Konstantinos K , Barroso Inês , Chen Ji , Frayling Timothy M , Bull Caroline J , Vincent Emma E , Cotterchio Michelle , Gruber Stephen B , Pai Rish K , Newcomb Polly A , Perez-Cornago Aurora , van Duijnhoven Franzel J B , Van Guelpen Bethany , Vodicka Pavel , Wolk Alicja , Wu Anna H , Peters Ulrike , Chan Andrew T , Gunter Marc J 
Published: January 2022

AbstractBackgroundGlycemic traits—such as hyperinsulinemia, hyperglycemia, and type 2 diabetes—have been associated with higher colorectal cancer risk in observational studies; however, causality of these associations is uncertain. We used Mendelian randomization (MR) to estimate the causal effects of fasting insulin, 2-hour glucose, fasting glucose, glycated hemoglobin (HbA1c), and type 2 diabetes with colorectal cancer.MethodsGenome-wide association study summary data were used to identify genetic variants associated with circulating levels of fasting insulin (n = 34), 2-hour glucose (n = 13), fasting glucose (n = 70), HbA1c (n = 221), and type 2 diabetes (n = 268). Using 2-sample MR, we examined these variants in relation to colorectal cancer risk (48 214 case patient and 64 159 control patients).ResultsIn inverse-variance models, higher fasting insulin levels increased colorectal cancer risk (odds ratio [OR] per 1-SD = 1.65, 95% confidence interval [CI] = 1.15 to 2.36). We found no evidence of any effect of 2-hour glucose (OR per 1-SD = 1.02, 95% CI = 0.86 to 1.21) or fasting glucose (OR per 1-SD = 1.04, 95% CI = 0.88 to 1.23) concentrations on colorectal cancer risk. Genetic liability to type 2 diabetes (OR per 1-unit increase in log odds = 1.04, 95% CI = 1.01 to 1.07) and higher HbA1c levels (OR per 1-SD = 1.09, 95% CI = 1.00 to 1.19) increased colorectal cancer risk, although these findings may have been biased by pleiotropy. Higher HbA1c concentrations increased rectal cancer risk in men (OR per 1-SD = 1.21, 95% CI = 1.05 to 1.40), but not in women.ConclusionsOur results support a causal effect of higher fasting insulin, but not glucose traits or type 2 diabetes, on increased colorectal cancer risk. This suggests that pharmacological or lifestyle interventions that lower circulating insulin levels may be beneficial in preventing colorectal tumorigenesis.
LAMN as a differential diagnosis for abdominal pain: a case report from Syria
Authors: Tarabishi Joudi , Douedari Alma , Almasalmeh Tahreer , Tarzi Mario 
Published: January 2022

Abstract
Low-grade appendiceal mucinous neoplasms (LAMNs) are papillary or flat mucinous tumors with low-grade cytologic atypia found in &lt;0.3% of appendectomy specimens among older population. They are the most frequent source of pseudomyxoma peritonei. They can be easily misdiagnosed, due to unspecific symptoms, with acute appendicitis, retroperitoneal tumors or adnexal mass. Macroscopically, the appendix may appear normal or be variably dilated. Microscopic study determines whether the studied specimen is LAMN or mucinous adenocarcinomas. We report a 77-year-old patient presented with 15-day abdominal pain accompanied with chills and hyperthermia. Decision was made for right hemicolectomy as a result of the findings on ultrasound and computed tomography scan. Diagnosis was made after the pathologic study, which revealedLAMN.
The C-terminus of a diatom plant-like cryptochrome influences the FAD redox state and binding of interaction partners
Authors: Krischer Julia , König Sarah , Weisheit Wolfram , Mittag Maria , Büchel Claudia 
Published: January 2022

Abstract
A plant-like cryptochrome of diatom microalgae, CryP, acts as a photoreceptor involved in transcriptional regulation. It contains FAD and 5,10-methenyltetrahydrofolate as chromophores. Here, we demonstrate that the unstructured C-terminal extension (CTE) of CryP has an influence on the redox state of the flavin. In CryP lacking the CTE, the flavin is in the oxidized state (FADox), whereas it is a neutral radical (FADH•) in the full-length protein. When the CTE of CryP is coupled to another diatom cryptochrome that naturally binds FADox, this chimera also binds FADH•. In full-length CryP, FADH• is the most stable redox state and oxidation to FADox is extremely slow, whereas reduction to FADH2 is reversible in the dark in approximately 1 h. We also identified novel interaction partners of this algal CRY and characterized two of them in depth regarding their binding activities. BolA, a putative transcription factor, binds to monomeric and to dimeric CryP via the CTE, independent of the redox state of the flavin. In contrast, an unknown protein, ID42612, which occurs solely in heterokont algae, binds only to CryP dimers. This binding is independent of the CTE and shows slight differences in strength depending on the flavin’s redox state.
Multiparametric Flow Cytometry versus Conventional Cytology in the Study of Leptomeningeal Involvement in Malignant Hematological Diseases
Authors: Altube Alejandra , Ceres Veronica , Malusardi Cecilia , Gonzalez Matteo Evelyn , Gimenez Cintia Lorena , Rocher Adriana Esther , Auat Mariángeles 
Published: January 2022

Abstract

Background
CNS involvement is a complication in hematologic malignant neoplasms. The advantage of multiparametric flow cytometry (MFC) over conventional cytology (CC) in detecting occult leptomeningeal disease in CSF has been proven previously, as reported in the literature. In this study, we reviewed the experience of our laboratory in evaluating CSF specimens by MFC and CC after refinement of technical procedures.

Methods
MFC analysis was performed in 159 specimens. In 91 specimens, simultaneous CC and MFC analysis was requested and results compared.

Results
Neoplastic cells were identified in 27 (17.0%) of the total samples and in 17 (18.7%) of the paired specimens group by MFC, compared with 2 (2.2%) specimens with positive results as determined by CC. MFC enabled identification of malignant cells in low-cellularity specimens (&lt;5 cells/μL) and all neoplasm categories.

Conclusion
MFC allowed the detection of minimal numbers of tumor cells in CSF specimens from individuals with leukemia and lymphoma in whom CC had not been able to identify those tumor cells.
Mass assembly history of dark matter haloes in the light of H0 tension
Authors: Kameli Hamed , Baghram Shant 
Published: January 2022

ABSTRACT
The Hubble tension may introduce a new course of action to revise the standard Lambda cold dark matter (ΛCDM) model to unravel dark energy and dark matter physics. The Hubble parameter can be reconstructed by late-time observations of the background evolution model independently. We relate the reconstructed Hubble parameter to the structure formation and large-scale structure observables in this work. We use excursion set theory to calculate the number density of dark matter haloes and the mass function of progenitors. We obtain results for both the Markov and non-Markov extensions of excursion set theory in the context of spherical and ellipsoidal collapse. We show that the number density of dark matter haloes in the reconstructed model has ∼2σ difference in comparison with the Planck 2018 ΛCDM in the mass range M ≳ 1012 M⊙. We also compare the dark matter halo progenitor mass function with the pair-galaxy statistics and their mass assembly history from observational data of the Hubble Space Telescope Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey. Due to complications in distinguishing the ratio of accretion and merger in mass assembly, our result on the pair fraction is for illustration only. However, the ∼5 times more accurate observations will be promising for distinguishing the reconstructed model and the Planck 2018 ΛCDM.
Cytoplasmic switch of ARS2 isoforms promotes nonsense-mediated mRNA decay and arsenic sensitivity
Authors: Mesa-Perez Monica , Hamilton Phineas T , Miranda Alex , Brodie Nicholas , O’Sullivan Connor , Christie Jennifer , Ryan Bridget C , Chow Robert L , Goodlett David , Nelson Christopher J , Howard Perry L 
Published: January 2022

Abstract
The life of RNA polymerase II (RNAPII) transcripts is shaped by the dynamic formation of mutually exclusive ribonucleoprotein complexes (RNPs) that direct transcript biogenesis and turnover. A key regulator of RNA metabolism in the nucleus is the scaffold protein ARS2 (arsenic resistance protein 2), bound to the cap binding complex (CBC). We report here that alternative splicing of ARS2′s intron 5, generates cytoplasmic isoforms that lack 270 amino acids from the N-terminal of the protein and are functionally distinct from nuclear ARS2. Switching of ARS2 isoforms within the CBC in the cytoplasm has dramatic functional consequences, changing ARS2 from a NMD inhibitor to a NMD promoter that enhances the binding of UPF1 to NCBP1 and ERF1, favouring SURF complex formation, SMG7 recruitment and transcript degradation. ARS2 isoform exchange is also relevant during arsenic stress, where cytoplasmic ARS2 promotes a global response to arsenic in a CBC-independent manner. We propose that ARS2 isoform switching promotes the proper recruitment of RNP complexes during NMD and the cellular response to arsenic stress. The existence of non-redundant ARS2 isoforms is relevant for cell homeostasis, and stress response.