bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do large‐scale associations in birds imply biotic interactions or environmental filtering?
Authors: Elo Merja , Kajanus Mira H. , Tolvanen Jere , Devictor Vincent , Forsman Jukka T. , Lehikoinen Aleksi , Mönkkönen Mikko , Thorson James T. , Vollstädt Maximilian G. R. , Kivelä Sami M. 
Published: November 2022

AbstractAimThere has been a wide interest in the effect of biotic interactions on species' occurrences and abundances at large spatial scales, coupled with a vast development of the statistical methods to study them. Still, evidence for whether the effects of within‐trophic‐level biotic interactions (e.g. competition and heterospecific attraction) are discernible beyond local scales remains inconsistent. Here, we present a novel hypothesis‐testing framework based on joint dynamic species distribution models and functional trait similarity to dissect between environmental filtering and biotic interactions.LocationFrance and Finland.TaxonBirds.MethodsWe estimated species‐to‐species associations within a trophic level, independent of the main environmental variables (mean temperature and total precipitation) for common species at large spatial scale with joint dynamic species distribution (a multivariate spatiotemporal delta model) models. We created hypotheses based on species' functionality (morphological and/or diet dissimilarity) and habitat preferences about the sign and strength of the pairwise spatiotemporal associations to estimate the extent to which they result from biotic interactions (competition, heterospecific attraction) and/or environmental filtering.ResultsSpatiotemporal associations were mostly positive (80%), followed by random (15%), and only 5% were negative. Where detected, negative spatiotemporal associations in different communities were due to a few species. The relationship between spatiotemporal association and functional dissimilarity among species was negative, which fulfils the predictions of both environmental filtering and heterospecific attraction.Main conclusionsWe showed that processes leading to species aggregation (mixture between environmental filtering and heterospecific attraction) seem to dominate assembly rules, and we did not find evidence for competition. Altogether, our hypothesis‐testing framework based on joint dynamic species distribution models and functional trait similarity is beneficial in ecological interpretation of species‐to‐species associations from data covering several decades and biogeographical regions.
Commentary: Why treatment is the best choice for childhood mental disorders – a commentary on Roest et al. (2022)
Authors: Dekkers Tycho J. , Groenman Annabeth P. , Cuijpers Pim , Hoekstra Pieter J. , Luman Marjolein , Orobio de Castro Bram , Overbeek Geertjan , Popma Arne , Rommelse Nanda , Salemink Elske , Stikkelbroek Yvonne A.J. , van den Hoofdakker Barbara J. , van der Oord Saskia , Leijten Patty 
Published: November 2022

An important question in mental healthcare for children is whether treatments are effective and safe in the long run. Here, we comment on a recent editorial perspective by Roest et al. (2022), who argue, based on an overview of systematic reviews, ‘that there is no convincing evidence that interventions for the most common childhood disorders are beneficial in the long term’. We believe that the available evidence does not justify this conclusion and express our concern regarding the harmful effects of their message. We show that there is evidence to suggest beneficial longer term treatment effects for each of the disorders and explain why evidence‐based treatment should be offered to children with mental disorders.
Should patients use online reviews to pick their doctors and hospitals?
Authors: Hyman David A. , Liu Jing , Black Bernard S. 
Published: November 2022

AbstractWe compare the online reviews of 221 “Questionable” Illinois and Indiana physicians with multiple paid medical malpractice claims and disciplinary sanctions with matched control physicians with clean records. Across five prominent online rating services, we find small, mostly insignificant differences in star ratings and written reviews for Questionable versus control physicians. Only one rating service (Healthgrades) reports on paid medical malpractice claims and disciplinary actions and it misses more than 90% of these actions. We also evaluate the online ratings of 171 Illinois hospitals and find that their ratings are largely uncorrelated with the share of hospital‐affiliated physicians with paid medical malpractice claims and disciplinary sanctions. Online ratings have limited utility in helping patients avoid physicians with troubled medical malpractice and disciplinary records, and steering patients away from hospitals at which more physicians have paid medical malpractice claims and disciplinary sanctions.
To feed or let eat! A scale of independence, exploration, and family to measure baby‐led weaning as a complementary feeding approach
Authors: Studer‐Perez Emma , Musher‐Eizenman Dara 
Published: November 2022

AbstractBackgroundThis article reports the development and validation of a measure of parents' use of baby‐led weaning (BLW). BLW is a child‐centred approach to complementary feeding where the infant is allowed to eat whole foods (rather than purees) and explore a variety of foods and textures. To date, parents' use of BLW has been assessed using either single items or a wide variety of measures.MethodIn this study, exploratory and confirmatory factor analyses on independent samples supported three BLW subscales: independence, exploration, and family.ResultsThe final 13‐item scale showed adequate fit statistics and good reliability (χ2(62) = 115.02, p < 0.001; CFI = 0.98; TLI = 0.98; RMSEA = 0.05; SRMR = 0.06; exploration a = 0.738; family a = 0.715; independence a = 0.809). In addition, the scale demonstrated good external validity and related in theoretically expected ways to an infant feeding‐style measure and parent report of complementary feeding approach. This study was limited as it was mostly white parents, and the scale should be validated on a more diverse sample.ConclusionsFuture research can use this scale to examine if BLW relates to infant taste preferences, parenting styles, and child eating behaviours to improve child nutrition and health outcomes.
Pathway‐based integration of multi‐omics data reveals lipidomics alterations validated in an Alzheimer's disease mouse model and risk loci carriers
Authors: Garcia‐Segura Monica Emili , Durainayagam Brenan R. , Liggi Sonia , Graça Gonçalo , Jimenez Beatriz , Dehghan Abbas , Tzoulaki Ioanna , Karaman Ibrahim , Elliott Paul , Griffin Julian L. 
Published: November 2022

AbstractAlzheimer's disease (AD) is a highly prevalent neurodegenerative disorder. Despite increasing evidence of the importance of metabolic dysregulation in AD, the underlying metabolic changes that may impact amyloid plaque formation are not understood, particularly for late‐onset AD. This study analyzed genome‐wide association studies (GWAS), transcriptomics, and proteomics data obtained from several data repositories to obtain differentially expressed (DE) multi‐omics elements in mouse models of AD. We characterized the metabolic modulation in these data sets using gene ontology, transcription factor, pathway, and cell‐type enrichment analyses. A predicted lipid signature was extracted from genome‐scale metabolic networks (GSMN) and subsequently validated in a lipidomic data set derived from cortical tissue of ABCA‐7 null mice, a mouse model of one of the genes associated with late‐onset AD. Moreover, a metabolome‐wide association study (MWAS) was performed to further characterize the association between dysregulated lipid metabolism in human blood serum and genes associated with AD risk. We found 203 DE transcripts, 164 DE proteins, and 58 DE GWAS‐derived mouse orthologs associated with significantly enriched metabolic biological processes. Lipid and bioenergetic metabolic pathways were significantly over‐represented across the AD multi‐omics data sets. Microglia and astrocytes were significantly enriched in the lipid‐predominant AD‐metabolic transcriptome. We also extracted a predicted lipid signature that was validated and robustly modeled class separation in the ABCA7 mice cortical lipidome, with 11 of these lipid species exhibiting statistically significant modulations. MWAS revealed 298 AD single nucleotide polymorphisms‐metabolite associations, of which 70% corresponded to lipid classes. These results support the importance of lipid metabolism dysregulation in AD and highlight the suitability of mapping AD multi‐omics data into GSMNs to identify metabolic alterations.image
Description and outcome of dogs with primary immune‐mediated polyarthritis: 73 cases (2012‐2017)
Authors: Ravicini S. , Kent A. , Dunning M. , Baines S. , Clarke S. , Allerton F. 
Published: November 2022

ObjectivesTo provide a description of primary idiopathic immune‐mediated polyarthritis, including long‐term outcome and relapse rates, for dogs starting treatment with corticosteroids alone or corticosteroids with a second immunosuppressant.Materials and MethodsMedical records were reviewed between January 2012 and December 2017 to identify dogs diagnosed with primary immune‐mediated polyarthritis. Data including signalment, clinicopathological findings, type and duration of treatment, relapse and outcome were recorded.ResultsSeventy‐three dogs were included. Fifty‐four dogs were started on corticosteroid monotherapy (an additional immunosuppressant was introduced later in 27/54 dogs) and 19 dogs were treated with multi‐modal immunosuppression from the outset. Ninety‐five percent (69/73) of dogs responded favourably to therapy although death was attributed to immune‐mediated polyarthritis in 19% (14/73) of dogs. Relapse of clinical signs was reported in 53% (39/73) dogs (31/39 while on treatment), with multiple relapses observed in 17 dogs. Complete cure (permanent withdrawal of immunosuppressive medication) was achieved in 46 dogs (63%). Overall, 81% of dogs had a well‐managed disease for an extended timeframe (≥1131 days). Fourteen of 19 (74%) dogs that started treatment with multi‐modal immunosuppression and 32 of 54 (59%) started on corticosteroids alone achieved a complete cure.Clinical SignificanceThis study provides extended follow‐up information for a large cohort of dogs with primary immune‐mediated polyarthritis. Immunosuppressive therapy was discontinued in the majority of dogs but disease‐associated mortality remains high.
Evaluation of cryodamage in small abalone, Haliotis diversicolor, spermatozoa by using a flow cytometer
Authors: Gwo Jin‐Chywan , Lei Shu‐Yi 
Published: November 2022

AbstractWe used flow cytometry to determine the quality of small abalone, Haliotis diversicolor, sperm before freezing and after thawing. We investigated the effects of cryopreservation on the characteristics of small abalone semen and determined the motility and fertilization capacity of the pre‐freezing and post‐thawed sperm. The percentages of motility and fertility were 61 ± 2% and 67 ± 1%, respectively, for the post‐thawed sperm and 90 ± 4% and 92 ± 0%, respectively, for the pre‐freezing sperm. Sperm cells were stained with specific fluorescent dyes to measure plasma and acrosomal membrane integrity, mitochondrial status, oxidation level, DNA compaction, and viability through flow cytometry. The frozen–thawed sperm exhibited significantly higher mitopotential activity (p < 0.05, damaged mitochondria; 25.01 ± 1.18%) and oxidation value (p < 0.01, free radicals; 63.79 ± 3.93%) compared with the pre‐freezing sperm. The oxidation level was the most sensitive signal of the cryopreservation‐induced small abalone sperm damage. Flow cytometry is valuable for the objective, accurate, and rapid assessment of pre‐freezing and post‐thaw small abalone sperm quality.
Of Two Arias and Nine Ragas: Analysing Monteverdi through a Karnatik Lens
Authors: Mani Charulatha 
Published: November 2022

ABSTRACTCommencing from an elaboration of extant theoretical and analytical positions in Monteverdi studies, this article closely analyses two of the most well‐known arias from Claudio Monteverdi's earliest opera,L'Orfeo(1607), from the melodic perspective of the Karnatik music of South India. In identifying ragas within Monteverdi's melodic structures, this approach evidences the author's practice‐based explorations of the arias while harking back to global influences that have shaped the identity formation of Western music. This approach to music analysis serves two primary purposes. First, it offers one way to decolonise and reimagine the music that emerged from an essentially multicultural early modern Europe. Second, in privileging artist‐researchers’ embodied oral aural knowledges, which emerge from practice, the approach makes a case for analytical approaches which aid in practice and which offer complementary lenses through which to view locate knowledges that are complex, embodied and non‐Western in their theoretical and analytical bases.
Prevalence of anemia and related nutrient deficiencies after sleeve gastrectomy: A systematic review and meta‐analysis
Authors: Nie Yuntao , Tian Ziru , Wang Pengpeng , Liu Baoyin , Zhang Nianrong , Zhou Biao , Wang Siqi , Hei Xiaofan , Meng Hua 
Published: November 2022

SummaryThis study aimed to investigate the prevalence of anemia and related nutrient deficiencies after sleeve gastrectomy (SG). Four online databases were searched for relevant articles. Thirty‐one studies with 7639 patients were included in the meta‐analysis. The pooled anemia prevalence was 7%, 6%, 9%, 10%, 12%, 25%, 20%, and 18% at baseline, 3 months, 6 months, 12 months, 24 months, 36 months, 48 months, and 60 months, respectively. Although the prevalence of vitamin B12 and folate deficiencies remained low postoperatively, the prevalence of ferritin deficiency steadily increased from 6% at baseline to 27% at 60 months. The prevalence of serum iron deficiency decreased from 13% at baseline to 6% at 24 months and increased to 20% at 60 months. Anemia and ferritin deficiency were strongly correlated (Pearson correlation coefficient = 0.774, p = 0.041). Subgroup analysis suggested that age ≤40 years, preoperative anemia, and insufficient iron supplementations were high‐risk factors for postoperative anemia. SG is associated with an increased risk of anemia and decreased iron storage over long‐term observation. Routine iron supplementations may reduce anemia after SG; however, the dosages recommended by current guidelines may be insufficient. More strict monitoring schedules and supplementation strategies should be established for the timely detection and management of postoperative anemia.
Melatonin delays ABA‐induced leaf senescence via H2O2‐dependent calcium signalling
Authors: Guo Yanliang , Zhu Jingyi , Liu Jiahe , Xue Yuxing , Chang Jingjing , Zhang Yong , Ahammed Golam Jalal , Wei Chunhua , Ma Jianxiang , Li Pingfang , Zhang Xian , Li Hao 
Published: November 2022

AbstractPrecocious leaf senescence can reduce crop yield and quality by limiting the growth stage. Melatonin has been shown to delay leaf senescence; however, the underlying mechanism remains obscure. Here, we show that melatonin offsets abscisic acid (ABA) to protect photosystem II and delay the senescence of attached old leaves under the light. Melatonin induced H2O2 accumulation accompanied by an upregulation of melon respiratory burst oxidase homolog D (CmRBOHD) under ABA‐induced stress. Both melatonin and H2O2 induced the accumulation of cytoplasmic‐free Ca2+ ([Ca2+]cyt) in response to ABA, while blocking of Ca2+ influx channels attenuated melatonin‐ and H2O2‐induced ABA tolerance. CmRBOHD overexpression induced [Ca2+]cyt accumulation and delayed leaf senescence, whereas deletion of Arabidopsis AtRBOHD, a homologous gene of CmRBOHD, compromised the melatonin‐induced [Ca2+]cyt accumulation and delay of leaf senescence in Arabidopsis under ABA stress. Furthermore, melatonin, H2O2 and Ca2+ attenuated ABA‐induced K+ efflux and subsequent cell death. CmRBOHD overexpression and AtRBOHD deletion alleviated and aggravated the ABA‐induced K+ efflux, respectively. Taken together, our study unveils a new mechanism by which melatonin offsets ABA action to delay leaf senescence via RBOHD‐dependent H2O2 production that triggers [Ca2+]cyt accumulation and subsequently inhibits K+ efflux and delays cell death/leaf senescence in response to ABA.
Convalescent plasma in hospitalized pediatric and obstetric coronavirus disease 2019 (COVID‐19) patients
Authors: Ikeda Saki , Benzi Eduardo , Hensch Lisa A. , Devaraj Sridevi , Hui Shiu‐Ki Rocky , Gandhi Manisha , Fox Karin A. , Teruya Jun , Munoz Flor M. 
Published: November 2022

AbstractBackgroundPublished data on coronavirus disease 2019 (COVID‐19) convalescent plasma (CCP) use in children and obstetric patients are limited. We describe a single‐center experience of hospitalized patients who received CCP for acute COVID‐19.MethodsA retrospective review of children 0–18‐years‐old and pregnant patients hospitalized with laboratory‐confirmed acute COVID‐19 who received CCP from March 1, 2020 to March 1, 2021 was performed. Clinical and laboratory data were collected to assess the safety of CCP administration. Antibodies to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) were measured in the CCP products and in patients before transfusion and at various time points post‐transfusion. Correlation between the administered SARS‐CoV‐2 administered versus the SARS‐CoV‐2 anti‐spike immunoglobulin response in patient serum was assessed.ResultsTwenty‐two children and ten obstetric patients were eligible. Twelve pediatric and eight obstetric patients had moderate disease and ten pediatric and two obstetric patients had severe disease. Five pediatric patients died. Eighteen of 37 (48.6%) CCP titers that were measured met US Food and Drug Administration (FDA) criteria for high immunoglobulin G (IgG) antibody titer. There were no complications with transfusion. High‐titer CCP showed a positive correlation with rise in patient total immunoglobulin levels only in obstetric patients but not in pediatric patients. Among pediatric patients, the median serum antibody level increased over time after transfusion.ConclusionsCoronavirus 2019 convalescent plasma was administered safely to our patients. Our study suggested that CCP did not interfere with endogenous antibody production. The antibody titer of CCP correlated with post‐transfusion response only in obstetric patients. Randomized trials in pediatric and obstetric patients are needed to further understand how to dose CCP and evaluate efficacy.
Posttransplant renal replacement therapy is an alarm signal for survival outcomes in pediatric liver transplantation
Authors: Yoo Byung Min , Hong Su Young , Hong Suk Kyun , Ahn Yo Han , Kang Hee Gyung , Lee Sola , Suh Sanggyun , Han Eui Soo , Lee Jeong‐Moo , Choi YoungRok , Lee Kwang‐Woong , Suh Kyung‐Suk , Yi Nam‐Joon 
Published: November 2022

AbstractBackgroundThe impact of renal replacement therapy (RRT) on the long‐term survival outcomes of pediatric liver recipients remains controversial.MethodsA total of 224 patients aged <18 years, who underwent liver transplantation (LT), were divided into two groups: patients who underwent renal replacement therapy (RRT) (group R, n = 25, 11.2%) and those who did not (group N, n = 199, 88.8%). The posttransplant patient survival outcomes according to RRT use constituted the primary end‐point. RRT was initiated preoperatively in 12 patients (48.0%) and postoperatively in 13 [early: <6 months after LT (n = 5, 20.0%) and late: ≥6 months after LT (n = 8, 32.0%)]. The indications for RRT included liver disease involving the kidney (44.0%) and hepatorenal syndrome (56.0%).ResultsThe age at the time of LT (71.6 vs. 19.1 months) was higher, the pediatric end‐stage liver disease score was lower (9.9 vs. 21.2), and the duration of hospitalization posttransplantation (41.0 vs. 27.0 days) was longer, while the rates of hepatic artery thrombosis (8.0% vs. 3.5%) were higher in group R (p < .05). The number of patients (60.0% vs. 93.0%; p < .001) and graft survival rates (68.0% vs. 93.0%; p < .001) were significantly lower in group R. Multivariate analysis revealed that posttransplant RRT and hepatic artery complications were risk factors for patient survival outcomes. Renal function was recovered in 7 patients (28.0%) in group R, and 9 (36.0%) eventually underwent kidney transplantation.ConclusionThe survival outcomes of children requiring posttransplant RRT were significantly worse than those of children, who did not undergo RRT. Physicians should pay meticulous attention to patients requiring post‐LT RRT.
Severe delayed graft function in a living‐related kidney transplant recipient due to combination of alloimmunity, autoimmunity, and heterologous immunity: A case report
Authors: Al Attas Rabab Ali , Alshami Alanoud , Mohamed Nasreen , Qahtani Zuhoor , Bamardouf Rafah , Alzahrani Saber 
Published: November 2022

AbstractBackgroundDelayed graft function is a manifestation of acute kidney injury unique to transplantation usually related to donor ischemia or recipient immunological causes. Ischemia also considered the most important trigger for innate immunity activation and production of non‐HLA antibodies. While ischemia is inevitable after deceased donor transplantation, this complication is rare after living transplantation. Heterologous Immunity commonly used to describe the activation of T cells recognizing specific pathogen‐related antigens as well unrelated antigens is common post‐viral infection. In transplant‐setting induction of heterologous immunity that cross‐react with HLA‐antigens and subsequent reactivation of memory T cells can lead to allograft rejection.MethodsHere we describe a non‐sensitized child with ESRD secondary to lupus nephritis and recent history of COVID‐19 infection who experienced 17 days of anuria after first kidney living transplantation from her young HLA‐haploidentical uncle donor. Graft histology showed acute cellular rejection, evidence of mild antibody‐mediated rejection and vascular wall necrosis in some arterioles suggesting possibility of intraoperative graft ischemia. Both pre‐ and post‐transplant sera showed very high level of several non‐HLA antibodies.ResultsThe patient was treated for cellular and antibody‐mediated rejection while maintained on hemodialysis before her graft function started to improve on day seventeen post transplantation.ConclusionThe cellular rejection likely trigged by ischemia that activated T‐cells‐mediated immunity. The high level of non‐ HLA‐antibodies further aggravated the damage and the rapid onset of rejection may be partly related to memory T‐cell activation induced by heterologous immunity.
Tributyrin supplementation in fish and crustacean nutrition: A review
Authors: Palma Mariana , Magnoni Leonardo J. , Morais Sofia , Viegas Ivan 
Published: November 2022

AbstractShort‐chain fatty acids, including butyrate and its derived forms, have been used as dietary supplements to reverse or ameliorate the potential negative effects of plant‐derived ingredients in aquaculture diets, and have a multitude of well‐demonstrated physiological and health enhancing effects in mammals and livestock. Tributyrin, a butyric acid derivate, has been assessed as a supplement in the diets of farmed animals, with promising results in several species. In fish and crustaceans, the dietary inclusion of tributyrin is more recent and has been less studied but results suggest that it may be highly advantageous for aquatic animals. This is particularly important for carnivorous species, whose diets need to be optimised towards the reduction of the fishmeal content to enhance the environmental and economical sustainability of the sector. The present work characterises tributyrin and presents the main results of its use as a dietary source of butyric acid in feeds for aquatic species. The main focus is given to aquaculture species and how tributyrin, as a feed supplement, can contribute to optimising plant‐based aquafeeds.