bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comprehensive and longitudinal cardiac magnetic resonance imaging study of the impact of coronary ischemia duration on myocardial damage in a highly translatable animal model
Authors: Radike Monika , Sutelman Pablo , Ben‐Aicha Soumaya , Gutiérrez Manuel , Mendieta Guiomar , Alcover Sebastià , Casaní Laura , Arderiu Gemma , Borrell‐Pages María , Padró Teresa , Badimon Lina , Vilahur Gemma 
Published: August 2022

AbstractObjectivesWe performed a comprehensive assessment of the effect of myocardial ischemia duration on cardiac structural and functional parameters by serial cardiac magnetic resonance (CMR) and characterized the evolving scar.BackgroundCMR follow‐up on the cardiac impact of time of ischemia in a closed‐chest animal model of myocardial infarction with human resemblance is missing.MethodsPigs underwent MI induction by occlusion of the left anterior descending (LAD) coronary artery for 30, 60, 90 or 120 min and then revascularized. Serial CMR was performed on day 3 and day 42 post‐MI. CMR measurements were also run in a sham‐operated group. Cellular and molecular changes were investigated.ResultsOn day 3, cardiac damage and function were similar in sham and pigs subjected to 30 min of ischemia. Cardiac damage (oedema and necrosis) significantly increased from 60 min onwards. Microvascular obstruction was extensively seen in animals with ≥90 min of ischemia and correlated with cardiac damage. A drop in global systolic function and wall motion of the jeopardized segments was seen in pigs subjected to ≥60 min of ischemia. On day 42, scar size and cardiac dysfunction followed the same pattern in the animals subjected to ≥60 min of ischemia. Adverse left ventricular remodelling (worsening of both LV volumes) was only present in animals subjected to 120 min of ischemia. Cardiac fibrosis, myocyte hypertrophy and vessel rarefaction were similar in the infarcted myocardium of pigs subjected to ≥60 min of ischemia. No changes were observed in the remote myocardium.ConclusionSixty‐minute LAD coronary occlusion already induces cardiac structural and functional alterations with longer ischemic time (120 min) causing adverse LV remodelling.
Comparison of Malaysia's Bachelor of Dental Technology curriculum with three other countries: Proposing a basic curriculum framework
Authors: Lin Galvin Sim Siang , Lee Yuet Qi , Ng Yue Myng , Cheah Yong Yie 
Published: August 2022

AbstractIntroductionA dental technologist is one of the most essential allied dental health professionals and the dental technology curriculum should be comprehensively reviewed on a regular basis. This study aims to compare the only existing Bachelor of Dental Technology (BDT) curriculum in Malaysia with BDT programmes offered by other well‐established universities, and map out the similarities and differences, as well as to explore future recommendations and propose a new curriculum framework.Materials and MethodsA descriptive analysis was carried out using Laurie Brady's four‐stage strategy. First, available curriculum materials were collected from four different institutions' electronic webpage: AIMST (Malaysia), GU (Australia), UO (New Zealand) and CMU (United Kingdom), and then compared based on three key domains: curriculum contents, teaching and learning strategies and assessments. Following that, the similarities and differences between various curricula were identified. Future recommendations and a curriculum framework were then proposed.ResultsThe core BDT curriculum content is concurred upon by all four universities, with an emphasis on basic sciences, laboratory materials, practical sessions and research projects. However, the credit weightage for each course or module varied across the four institutions, with some offering unique subjects and implementing different teaching methods and assessments. A simple BDT curriculum framework with a proposed syllabus was designed based on the three key domains and future recommendations for curriculum improvement were explored.ConclusionThe present study identified several areas for Malaysian BDT curriculum development and improvement. The proposed framework can be a guide for Malaysian dental schools in designing a comprehensive dental technology programme.
Narrowly defined taxa on a global scale: The phylogeny and taxonomy of the genera Catriona and Tenellia (Nudibranchia, Trinchesiidae) favours fine‐scale taxonomic differentiation and dissolution of the “lumpers & splitters” dilemma
Authors: Korshunova Tatiana , Lundin Kennet , Malmberg Klas , Martynov Alexander 
Published: August 2022

AbstractBy applying morphological and molecular data on two genera of the nudibranch molluscs it is shown that the tension between taxonomic practice and evolutionary processes persists. A review of the related genera Catriona and Tenellia is used to demonstrate that the fine‐scale taxonomic differentiation is an important tool in the integration of morphological and molecular data. This is highlighted by the hidden species problem and provides strong argument that the genus must be kept as a maximally narrowly‐defined entity. Otherwise, we are forced to compare a highly disparate species under the putatively lumped name “Tenellia”. We demonstrate this in the present study by applying a suite of delimitation methods and describing a new species of Tenellia from the Baltic Sea. The new species possesses fine‐scale morphological distinguishing features, which were not investigated before. The true, narrowly defined genus Tenellia represents a peculiar taxon with a clearly expressed paedomorphic characters and predominantly brackish‐water habitats. The phylogenetically related genus Catriona, of which three new species are described here, clearly demonstrates different features. A lumping decision to call many morphologically and evolutionary different taxa as “Tenellia” will downgrade the taxonomic and phylogenetic resolution of the entire family Trinchesiidae to just a single genus. The dissolution of the dilemma of “lumpers & splitters”, which still significantly affects taxonomy, will further help to make systematics a true evolutionary discipline.
The ultimate question? Evaluating the use of Net Promoter Score in healthcare: A systematic review
Authors: Adams Corey , Walpola Ramesh , Schembri Anthony M. , Harrison Reema 
Published: August 2022

AbstractBackgroundPatient experience is a complex phenomenon that presents challenges for appropriate and effective measurement. With the lack of a standardized measurement approach, efforts have been made to simplify the evaluation and reporting of patient experience by using single‐item measures, such as the Net Promoter Score (NPS). Although NPS is widely used in many countries, there has been little research to validate its effectiveness and value in the healthcare setting. The aim of this study was to systematically evaluate the evidence that is available about the application of NPS in healthcare settings.MethodsStudies were identified using words and synonyms that relate to NPS, which was applied to five electronic databases: Medline, CINAHL, Proquest, Business Journal Premium, and Scopus. Titles and abstracts between January 2005 and September 2020 were screened for relevance, with the inclusion of quantitative and qualitative studies in the healthcare setting that evaluated the use of NPS to measure patient experience.ResultsTwelve studies met the inclusion criteria. Four studies identified benefits associated with using NPS, such as ease of use, high completion rates and being well‐understood by a range of patients. Three studies questioned the usefulness of the NPS recommendation question in healthcare settings, particularly when respondents are unable to select their service provider. The free‐text comments section, which provides additional detail and contextual cues, was viewed positively by patients and staff in 4 of 12 studies. According to these studies, NPS can be influenced by a wide range of variables, such as age, condition/disease, intervention and cultural variation; therefore, caution should be taken when using NPS for comparisons. Four studies concluded that NPS adds minimal value to healthcare improvement.ConclusionThe literature suggests that many of the proposed benefits of using NPS are not supported by research. NPS may not be sufficient as a stand‐alone metric and may be better used in conjunction with a larger survey. NPS may be more suited for use in certain healthcare settings, for example, where patients have a choice of provider. Staff attitudes towards the use of NPS for patient surveying are mixed. More research is needed to validate the use of NPS as a primary metric of patient experience.Patient or Public ContributionConsumer representatives were provided with the research findings and their feedback was sought about the study. Consumers commented that they found the results to be useful and felt that this study highlighted important considerations when NPS data is used to evaluate patient experience.
Improved survival in real‐world patients with advanced urothelial carcinoma: A multicenter propensity score‐matched cohort study comparing a period before the introduction of pembrolizumab (2003–2011) and a more recent period (2016–2020)
Authors: Taguchi Satoru , Kawai Taketo , Nakagawa Tohru , Miyakawa Jimpei , Kishitani Kenjiro , Sugimoto Kazuma , Nakamura Yu , Kamei Jun , Obinata Daisuke , Yamaguchi Kenya , Kaneko Tomoyuki , Yoshida Kanae , Yamamoto Sachi , Kakutani Shigenori , Kanazawa Koichiro , Sugihara Yuriko , Tokunaga Mayuko , Matsumoto Akihiko , Uemura Yukari , Akiyama Yoshiyuki , Yamada Yuta , Sato Yusuke , Yamada Daisuke , Enomoto Yutaka , Nishimatsu Hiroaki , Ishikawa Akira , Tanaka Yoshinori , Nagase Yasushi , Fujimura Tetsuya , Fukuhara Hiroshi , Takahashi Satoru , Kume Haruki 
Published: August 2022

AbstractObjectivesAlthough the treatment strategy for advanced urothelial carcinoma (aUC) has drastically changed since pembrolizumab was introduced in 2017, studies revealing current survival rates in aUC are lacking. This study aimed to assess (1) the improvement in survival among real‐world patients with aUC after the introduction of pembrolizumab and (2) the direct survival‐prolonging effect of pembrolizumab.MethodsThis multicenter retrospective study included 531 patients with aUC undergoing salvage chemotherapy, including 200 patients treated in the pre‐pembrolizumab era (2003–2011; earlier era) and 331 patients treated in a recent 5‐year period (2016–2020; recent era). Using propensity score matching (PSM), cancer‐specific survival (CSS) and overall survival (OS) were compared between the earlier and recent eras, in addition to between the recent era, both with and without pembrolizumab use, and the earlier era.ResultsAfter PSM, the recent era cohort had significantly longer CSS (21 months) and OS (19 months) than the earlier era cohort (CSS and OS: 12 months). In secondary analyses using PSM, patients treated with pembrolizumab had significantly longer CSS (25 months) and OS (24 months) than those in the earlier era cohort (CSS and OS: 11 months), whereas patients who did not receive pembrolizumab in the recent era had similar outcomes (CSS and OS: 14 months) as the earlier era cohort (CSS and OS: 12 months).ConclusionsPatients with aUC treated in the recent era exhibited significantly longer survival than those treated before the introduction of pembrolizumab. The improved survival was primarily attributable to the use of pembrolizumab.
Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis
Authors: Chen Bao Ying , Salas Jessica R. , Trias Alyssa O. , Perez Rodriguez Arely , Tsang Jonathan E. , Guemes Miriam , Le Thuc M. , Galic Zoran , Shepard H. Michael , Steinman Lawrence , Nathanson David A. , Czernin Johannes , Witte Owen N. , Radu Caius G. , Schultz Kenneth A. , Clark Peter M. 
Published: August 2022

AbstractMultiple sclerosis (MS) is an autoimmune disease driven by lymphocyte activation against myelin autoantigens in the central nervous system leading to demyelination and neurodegeneration. The deoxyribonucleoside salvage pathway with the rate‐limiting enzyme deoxycytidine kinase (dCK) captures extracellular deoxyribonucleosides for use in intracellular deoxyribonucleotide metabolism. Previous studies have shown that deoxyribonucleoside salvage activity is enriched in lymphocytes and required for early lymphocyte development. However, specific roles for the deoxyribonucleoside salvage pathway and dCK in autoimmune diseases such as MS are unknown. Here we demonstrate that dCK activity is necessary for the development of clinical symptoms in the MOG35–55 and MOG1–125 experimental autoimmune encephalomyelitis (EAE) mouse models of MS. During EAE disease, deoxyribonucleoside salvage activity is elevated in the spleen and lymph nodes. Targeting dCK with the small molecule dCK inhibitor TRE‐515 limits disease severity when treatments are started at disease induction or when symptoms first appear. EAE mice treated with TRE‐515 have significantly fewer infiltrating leukocytes in the spinal cord, and TRE‐515 blocks activation‐induced B and T cell proliferation and MOG35–55‐specific T cell expansion without affecting innate immune cells or naïve T and B cell populations. Our results demonstrate that targeting dCK limits symptoms in EAE mice and suggest that dCK activity is required for MOG35–55‐specific lymphocyte activation‐induced proliferation.
Understanding the Turkish adolescents' weight perception: A cross‐sectional study
Authors: Esenay Figen I. , Sezer Tufan A. 
Published: August 2022

AbstractProblemAdolescence is regarded as a period in which adolescents go through a number of physical changes in appearance and a transition from childhood to adulthood. Throughout this transitional period, adolescents become more concerned with their size and weight. The aim of this study was to determine the self‐perceived weights status of adolescents 11–19 years old.MethodsA cross‐sectional study was conducted with a sample of 1459 students, aged 11–19 years, in Turkey. Anthropometric measurements of weight and height were measured with appropriate tools and adolescents' self‐perception of weight status was assessed by the Figure Rating Scale.FindingsNearly half of the adolescents had misperceptions about their weight status (49.6%). There was a significant association between body mass index (BMI) z‐score categories and weight status misperception. Overall, the weight status misperception was more common among the girls than boys.ConclusionMisperception of weight status in adolescent should take into account the following: development of intervention programs aimed at screening weight and weight perception, empowering young people to have accurate weight status perception, and raising awareness of the issue in school health professionals.
The efficacy of coenzyme Q10 treatment in alleviating the symptoms of primary coenzyme Q10 deficiency: A systematic review
Authors: Wang Ying , Hekimi Siegfried 
Published: August 2022

AbstractCoenzyme Q10 (CoQ10) is necessary for mitochondrial electron transport. Mutations in CoQ10 biosynthetic genes cause primary CoQ10 deficiency (PCoQD) and manifest as mitochondrial disorders. It is often stated that PCoQD patients can be treated by oral CoQ10 supplementation. To test this, we compiled all studies describing PCoQD patients up to May 2022. We excluded studies with no data on CoQ10 treatment, or with insufficient description of effectiveness. Out of 303 PCoQD patients identified, we retained 89 cases, of which 24 reported improvements after CoQ10 treatment (27.0%). In five cases, the patient's condition was reported to deteriorate after halting of CoQ10 treatment. 12 cases reported improvement in the severity of ataxia and 5 cases in the severity of proteinuria. Only a subjective description of improvement was reported for 4 patients described as responding. All reported responses were partial improvements of only some symptoms. For PCoQD patients, CoQ10 supplementation is replacement therapy. Yet, there is only very weak evidence for the efficacy of the treatment. Our findings, thus, suggest a need for caution when seeking to justify the widespread use of CoQ10 for the treatment of any disease or as dietary supplement.
Reduced lifetime fitness (growth, body condition and survivability) of hatchery‐reared tiger pufferfish Takifugu rubripes compared to wild counterparts
Authors: Ogino Yoshimi , Yamaguchi Atsuko 
Published: August 2022

AbstractTiger pufferfish Takifugu rubripes (order Tetraodontiformes, family Tetraodontidae) is a highly exploited species and stocks continue to decline, although hatchery‐reared juveniles have been released since 1965 for stock enhancement. To determine why the stock has not recovered through hatchery‐release practices, this study investigated and compared the population characteristics of wild and hatchery‐origin fish. The length–mass relationship showed that hatchery‐origin fish were skinnier, with males weighing less than 90% of the mass of wild males of the same length. The hepatosomatic index tended to be lower in hatchery‐origin fish. Age was estimated using the otolith‐based method, and the estimates were more accurate and precise than those obtained by the conventional vertebra‐based method. At the age of 2.9 years, an age at which specimens were the most abundant in catches, hatchery‐origin males weighed only 67% of wild males. The maximum observed age was 12 years for wild fish and 5 years for hatchery‐origin fish. The instantaneous total mortality rates of hatchery‐origin fish were more than twice as high as those of wild fish. In summary, the hatchery‐origin fish had poor health status, poor growth and high mortality, and their fitness in natural environments was therefore hypothesized to be low throughout life.
Evaluation and comparison in caffeine extraction under green conditions: Solvent selection and ultrasound‐assisted process
Authors: Serna‐Jiménez Johanna Andrea , Torres‐Valenzuela Laura Sofía , Mejía‐Arango Gabriel 
Published: August 2022

AbstractThis study compared the green solvents ethyl acetate and water for caffeine extraction from coffee pills against four traditional solvents (ethanol, methanol, acetone, and acetonitrile). Each solvent's green degree (GD) was calculated using seven environmental and technical performance parameters. The environmental parameters were obtained from the Glaxo Smith Kline guide. Fick's law of effective diffusion was used as the technical parameter. Water was selected as the preferred solvent (among the six evaluated in this study), and its ultrasound‐assisted extraction (UAE) conditions were optimized. The optimal conditions were estimated by ridge analysis. It was found that caffeine extraction was approximately 4.3 times higher in UAE than in conventional solid–liquid processes, and the extraction time was reduced by 96%. Moreover, this process improved caffeine extraction with water. Therefore, the use of UAE over conventional solid extraction and water as an inexpensive, easily accessible, manageable, and environmentally friendly solvent provides extraction alternatives for caffeine in different matrices. Additionally, a methodology is proposed to evaluate the GD for each solvent in the green chemistry framework to achieve sustainable development goals.
Serum vitamin D and cardiometabolic risk factors in the UK population
Authors: Patel Linia , Vecchia Carlo La , Alicandro Gianfranco 
Published: August 2022

AbstractWe analysed data on 2842 subjects aged ≥40 years enrolled in the National Diet and Nutrition Survey (NDNS 2008–2019). Based on serum 25(OH)D concentrations, study subjects were grouped in three categories: vitamin D deficiency (<25 nmol/L), vitamin D insufficiency (25–49 nmol/L) and vitamin D sufficiency status (≥50 nmol/L). Differences in CVD risk factors between vitamin D deficiency or insufficiency and vitamin D sufficiency status were expressed in standard deviation scores (SDS) and estimated through weighted multiple linear regression models.
Populist Syndrome and Nonmarket Strategy
Authors: Blake Daniel J. , Markus Stanislav , Martinez‐Suarez Julio 
Published: August 2022

AbstractAlthough recognized as a defining feature of the current political era, populism and its implications for non‐market strategy remain undertheorized. We offer a framework that (a) conceptualizes populism and its progression over time; (b) outlines the risks populism generates for firms; and (c) theorizes effective nonmarket strategies under populism. Our framework anchors the political risk profile of populism in three interdependent elements: anti‐establishment ideology, de‐institutionalization, and short‐term policy bias. These elements jointly shape the policymaking dynamics and institutional risks for firms under populism. Our analysis shows how firms can calibrate two nonmarket strategies – political ties and corporate social responsibility – to mitigate populism‐related risks. We specify how particular configurations of political ties and CSR activities, aimed at the populist leadership, bureaucrats, political opposition, and societal stakeholders, minimize risk under populism. Further, we theorize how the effectiveness of specific attributes of political ties and CSR – namely their relative covertness (more vs. less concealed) and their relative focus (narrowly vs. widely targeted) – varies as a function of firm type (insiders vs. outsiders) and the probability of populist regime collapse. Finally, we address how motivated reasoning may bias firms' assessments of regime fragility and resulting strategy choices.
Evaluation of a nausea assessment tool in the pediatric oncology population
Authors: Donaghey Christopher T. , Bowers Cynthia , Kiefer Juliann 
Published: August 2022

AbstractPurposeNausea is a symptom that is often experienced but misunderstood. Its impact is amplified in pediatric oncology patients. Nausea assessments in pediatric oncology are few and not yet widely used. The Baxter Retching Faces (BARF) scale holds promise and is used in some pediatric oncology units. The purpose of this evidence‐based practice project was to evaluate the impact of the BARF scale on nursing assessments in inpatient pediatric hematology/oncology and stem cell transplant settings.ConclusionsProject work took place on one hematology/oncology unit and one stem cell transplant unit. Thirty nurses completed the acceptability of intervention measure (AIM), intervention appropriateness measure (IAM), and feasibility of intervention measure (FIM) to provide initial feedback on the BARF scale. Nurses used the BARF scale over an 8‐week period. Patient demographics and BARF scores were collected during nausea assessments. Twenty nurses completed AIM/IAM/FIM scores postintervention. There were no significant changes in scores, though nurses stated that the tool was easy to use and provided valuable symptom feedback.Practice ImplicationsSymptom management will continue to be a challenge in the pediatric setting given developmental and disease‐specific considerations inherent to the specialty. While this small‐scale project did not achieve statistical significance, the evidence and feedback from nursing staff present a compelling case that efforts to investigate and integrate improved methods of assessing nausea and other problematic symptoms are needed to enhance nursing practice and impact patient‐centered outcomes.