bluuebunny/crossref_metadata_2025_split huggingface dataset:
Muscular anatomy of the forelimb of tiger (Panthera tigris)
Authors: Dunn Rachel H. , Beresheim Amy , Gubatina Ariel , Bitterman Kathleen , Butaric Lauren , Bejes Katelyn , Kennedy Sarah , Markham Sam , Miller Dustin , Mrvoljak Midhad , Roge‐Jones Lorraine , Stumpner Jessica , Walter Cody , Meachen Julie A. 
Published: February 2022

AbstractDissection reports of large cats (family Felidae) have been published since the late 19th century. These reports generally describe the findings in words, show drawings of the dissection, and usually include some masses of muscles, but often neglect to provide muscle maps showing the precise location of bony origins and insertions. Although these early reports can be highly useful, the absence of visual depictions of muscle attachment sites makes it difficult to compare muscle origins and insertions in living taxa and especially to reconstruct muscle attachments in fossil taxa. Recently, more muscle maps have been published in the primary literature, but those for large cats are still limited. Here, we describe the muscular anatomy of the forelimb of the tiger (Panthera tigris), and compare muscle origins, insertions, and relative muscle masses to other felids to identify differences that may reflect functional adaptations. Our results reiterate the conservative nature of felid anatomy across body sizes and behavioral categories. We find that pantherines have relatively smaller shoulder muscle masses, and relatively larger muscles of the caudal brachium, pronators, and supinators than felines. The muscular anatomy of the tiger shows several modifications that may reflect an adaptation to terrestrial locomotion and a preference for large prey. These include in general a relatively large m. supraspinatus (shoulder flexion), an expanded origin for m. triceps brachii caput longum, and relatively large m. triceps brachii caput laterale (elbow extension), as well as relatively large mm. brachioradialis, abductor digiti I longus, and abductor digiti V. Muscle groups that are well developed in scansorial taxa are not well developed in the tiger, including muscles of the cranial compartment of the brachium and antebrachium, and m. anconeus. Overall, the musculature of the tiger strongly resembles that of the lion (Panthera leo), another large‐bodied terrestrial large‐prey specialist.
1470‐nm Radial fiber‐assisted liposuction for body contouring and facial fat grafting
Authors: Heller Lior , Menashe Shaked , Plonski Lori , Ofek Andre , Pozner Jason N. 
Published: February 2022

AbstractBackgroundLaser‐assisted liposuction using 1470‐nm radial fiber emits light energy preferentially absorbed by water, yielding a rapid and localized contouring and tightening effect, with minimal scarring. When collected under appropriate conditions, extracted fat samples can be exploited as autologous filling material in liposculpturing procedures.ObjectivesTo assess the 6‐month contouring efficacy of 1470 radial fiber‐assisted liposuction and the volumetric enhancement effect of the harvested tissue in facial fat grafting.MethodsTwenty subjects underwent liposuction (BeautiFill, Alma Lasers, Inc.) of lower abdominal or outer thigh fat. In seven subjects, harvested samples were grafted into facial regions. Treatment safety, body weight, blinded evaluator‐assessed aesthetic improvements, and subject‐rated satisfaction were monitored for 6 months. Abdominal and facial fat thickness were assessed by magnetic resonance imaging (n = 5) within 3 months of treatment.ResultsOne‐month posttreatment, most subjects ranked improvements good/excellent (88%) and skin tightening satisfactory/very satisfactory (92%), with >70% of subjects providing similar scores 6‐month posttreatment. Blinded evaluators noted improved/very much improved aesthetic appearance (87%). Harvested tissue injected as a facial filler (21.0 ± 5.2 ml) led to a 0.63 ± 0.12 mm increase in facial fat thickness, observed by MRI, within 3 months. Six months postfilling, the majority of subjects (83%) were satisfied with the outcome. All procedures were well‐tolerated.ConclusionsA single 1470 nm radial fiber‐assisted abdominal and thigh liposuction session provided for effective and durable reduction of adipose tissue deposits, with appreciable skin tightening and aesthetic improvements. The gentle harvesting method yielded viable filler material, which was well‐retained in facial regions for up to 6 months.
ETHICAL DISSONANCE, ETHICAL DISJUNCTURE, AND THE AUTONOMOUS SPHERES
Authors: Shingleton Bradley 
Published: February 2022

AbstractThe contemporary ethical landscape appears to many to be marked by a plurality of normative regions. The values and standards of one region may contrast and conflict with those of other regions, creating a sense of dissonance and discontinuity for the individual agent. This article explores how the phenomenon of such dissonance might be conceptualized. It considers the attempts of two thinkers who, following on Weber's notion of autonomous spheres, give a theoretical account of a pluralized ethical environment in terms of distinct, autonomous zones that reflect distinctive assumptions about rationality and action. While such Weber‐inspired theories are compelling in some respects, they have the potential of overemphasizing the autonomy of the various regions. An alternative idea of ethical sectors, rather than orders, seeks to avoid this problem by positing a more porous, less delimited ethical landscape, one that allows for a sense of ethical identity that an agent can maintain across different sectors.
“Justly Shall You Pursue Justice”: Theological Approaches to Evaluative Injustice
Authors: Muers Rachel 
Published: February 2022

AbstractThis article identifies and characterizes the phenomenon of evaluative injustice as the inequitable positioning of persons in relation to the activity of moral judgment, or the inequitable configuration of the space of moral judgment. The two main, closely interconnected, aspects of evaluative injustice are the disproportionate exposure of certain groups to moral judgment, and the disproportionate exclusion of certain groups from agency in moral judgment. Having argued that theology is significantly implicated in, and obligated to respond to, evaluative injustice, I outline a theological response to evaluative injustice through a reading of biblical texts on divine impartiality. The core focus should not be the abstract ideal of impartiality, but rather the role of “judges” and moral reasoners in recognizing and addressing pervasive social injustice.
A time to consider, a time to deliver: The independent and interactive effects of regulatory mode on innovative work behavior
Authors: Liu Haixin , Rubenstein Alex L. , Li Guiquan , Liu Zhaoyan , Zhan Xiaojun , Xiong Jie 
Published: February 2022

AbstractAlthough innovative work behavior (IWB) is essential to organizational success and survival, little is known about its dispositional antecedents. In this study, we invoke regulatory mode theory to examine the independent and interactive effects of two regulatory orientations, assessment and locomotion, on three aspects of employee IWB: idea generation, promotion, and realization. Results from lagged survey data generally supported our hypotheses that each orientation would exhibit distinct effect patterns. For idea generation, assessment exhibited a positive relationship, whereas locomotion exhibited a negative relationship. Meanwhile, only locomotion was significantly (positively) related to idea promotion. And for idea realization, both assessment and locomotion exhibited positive associations. Furthermore, the interaction of assessment and locomotion in relation to each aspect of IWB also revealed distinct patterns: for idea generation, higher levels of assessment buffered against the negative effects of locomotion; for idea promotion, higher assessment constrained the positive effects of locomotion; and for idea realization, assessment supported locomotion, such that we observed greater realization levels when both regulatory modes were higher. We discuss the theoretical and practical implications of our results, as well as promising directions for future research concerning both regulatory mode and IWB.
Patient‐specific genetic factors predict treatment failure in sofosbuvir‐treated patients with chronic hepatitis C
Authors: Loucks Catrina M. , Lin Jennifer J. , Trueman Jessica N. , Drögemöller Britt I. , Wright Galen E. B. , Chang Wan‐Chun , Li Kathy H. , Yoshida Eric M. , Ford Jo‐Ann , Lee Samuel S. , Crotty Pam , Kim Richard B. , Al‐Judaibi Bandar , Schwarz Ute I. , Ramji Alnoor , Farivar Jeanette F. , Tam Edward , Walston Lori Lee , Ross Colin J. D. , Carleton Bruce C. 
Published: February 2022

AbstractBackground & AimsAccording to pivotal clinical trials, cure rates for sofosbuvir‐based antiviral therapy exceed 96%. Treatment failure is usually assumed to be because of virological resistance‐associated substitutions or clinical risk factors, yet the role of patient‐specific genetic factors has not been well explored. We determined if patient‐specific genetic factors help predict patients likely to fail sofosbuvir treatment in real‐world treatment situations.MethodsWe recruited sofosbuvir‐treated patients with chronic hepatitis C from five Canadian treatment sites, and performed a case‐control pharmacogenomics study assessing both previously published and novel genetic polymorphisms. Specifically studied were variants predicted to impair CES1‐dependent production of sofosbuvir’s active metabolite, interferon‐λ signalling variants expected to impact a patient’s immune response to the virus and an HLA variant associated with increased spontaneous and treatment‐induced viral clearance.ResultsThree hundred and fifty‐nine sofosbuvir‐treated patients were available for analyses after exclusions, with 34 (9.5%) failing treatment. We identified CES1 variants as novel predictors for treatment failure in European patients (rs115629050 or rs4513095; odds ratio (OR): 5.43; 95% confidence interval (CI): 1.64‐18.01; P = .0057), replicated associations with IFNL4 variants predicted to increase interferon‐λ signalling (eg rs12979860; OR: 2.25; 95% CI: 1.25‐4.06; P = .0071) and discovered a novel association with a coding variant predicted to enhance the activity of IFNL4's receptor (rs2834167 in IL10RB; OR: 1.81; 95% CI: 1.01‐3.24; P = .047).ConclusionsUltimately, this work demonstrates that patient‐specific genetic factors could be used as a tool to identify patients at higher risk of treatment failure and allow for these patients to receive effective therapy sooner.
Advances in understanding of the natural history, mechanism, extra‐muscular manifestations and treatment of GNE myopathy
Authors: Yoshioka Wakako , Noguchi Satoru , Mori‐Yoshimura Madoka , Nishino Ichizo 
Published: February 2022

AbstractGNE myopathy is an autosomal recessive adult‐onset distal myopathy caused by biallelic variants in the GNE gene, which encodes a protein with two key enzymatic activities in the biosynthesis of sialic acid. In 1981, there was a report of a Japanese family in which muscle biopsies showed rimmed vacuoles in tibialis anterior with relative sparing of the quadriceps muscles. Twenty years later, the causative gene was identified to be GNE. Our group has constructed a mouse model that recapitulates the symptoms of GNE myopathy in patients and demonstrates the therapeutic effects of oral sialic acid supplementation on muscle phenotypes. The first clinical trial of N‐acetylneuraminic acid (NeuAc) was conducted in 2010 at Tohoku University, and several clinical trials are now underway at multiple sites. Patient registries have also been started, including the Japanese Registry of Muscular Dystrophy (Remudy, established in 2012) and the online international GNE Myopathy Disease Monitoring Program (launched in 2014). These registries have allowed collection of comprehensive patient data, including new clinical features suggesting that GNE myopathy is not only a disease of skeletal muscle. In this review, we summarize the history of research on GNE myopathy and discuss the mechanism of the disease and its more recently identified features.
Breast cancer screening practices and associated factors among Chinese‐Australian women living in Sydney: A cross‐sectional survey study
Authors: Wang Lei , Mackenzie Lynette , Hossain Zakia 
Published: February 2022

AbstractThis study aimed to investigate breast cancer screening practices and associated factors among Chinese‐Australian women. A cross‐sectional quantitative survey method including convenience and snowball sampling was used to recruit 115 Chinese‐Australian women living in Sydney, using a self‐administered survey. In all, 69.8% of participants reported recent clinical breast examinations and 73.3% had mammograms. Age, religion, employment status, and length of residence were associated with having a clinical breast examination. Income was related to having a mammogram. Associations between knowledge of breast cancer, cancer‐related beliefs, and screening participation were found. Length of residence in Australia was the strongest predictor of having a clinical breast examination and mammogram. The most common barrier to mammography was if women felt that doctors did not recommend it to them. Chinese‐Australian women need to be educated about awareness of their usual breast health to be aware of any changes, especially if women are not eligible for mammography or have difficulty in accessing health services. Tailored programs, improving screening experiences, and minimizing perceived barriers are needed to promote early detection of breast cancer among Chinese–Australian women.
The COVID‐19 pandemic: Narratives of front‐line nurses from Wuhan, China
Authors: Zhang Wei Qing , Montayre Jed , Ho Mu‐Hsing , Yuan Fang , Chang Hui‐Chen (Rita) 
Published: February 2022

AbstractThis study aimed to explore the experiences of nurses in Wuhan Hospital as front‐line workers during the COVID‐19 pandemic. A descriptive qualitative study of such nurses was conducted from a tertiary hospital in Wuhan. Semi‐structured individual interviews were undertaken with 8 registered nurses who were front‐line health workers in one of the COVID‐19 wards and 3 nursing managers from the response team. Five discrete themes were identified from the narratives of nurses' experiences during the COVID‐19 outbreak in Wuhan: “content of fundamental care,” “teamwork,” “reciprocity,” “nurses’ own worries,” and “lifelong learning and insights.” Nurses in the front line of care during the COVID‐19 pandemic can contribute important information from their hands‐on experience for providing a holistic response to an infectious outbreak like COVID‐19. The concerns nurses raised at both personal and professional levels have implications for nursing education and clinical practice settings, particularly in the time of a pandemic when nurses' well‐being requires attention, and at the same time for considering organizational factors that enable nurses to provide care to patients with confidence. Hospital policies and nursing management need to be ready and adhere to flexible work planning systems and approaches during a pandemic.
Effect of oil price volatility on the trade balance in sub‐Saharan Africa
Authors: Forson Priscilla , Dramani John Bosco , Frimpong Prince Boakye , Arthur Eric , Mahawiya Sulemana 
Published: February 2022

AbstractCrude oil price volatility as an important driver of the trade balance of economies has been widely documented in the literature. However, studies on the effect of oil price volatility on the trade balance in sub‐Sahara Africa (SSA) are limited. In this paper, we explore the effect of crude oil price volatility on the trade balance across 34 SSA countries using Pooled Mean Group (PMG) and Common Correlated Effect Pooled Mean Group (CCEPMG) estimators for the period January 2004 to December 2017. We find that crude oil price volatility exerts a negative effect on the trade balance of SSA countries. We further demonstrate that inflation, interest rates and exchange rates are significant transmission channels for oil price volatility to impact trade balance. We suggest that policymakers hedge as well as adopt price‐smoothing schemes to minimise the volatility of oil prices on trade balance. Again, countries should adopt an inflation‐targeting regime to ensure the stability of the general price level. Finally, central banks of the respective countries should apply a combination of foreign exchange market interventions and interest rate changes to reduce the effect of oil price volatility on their trade balance when the exchange rate is taken into account.
The effect of image resolution of display types on accommodative microfluctuations
Authors: Hynes Niall J , Cufflin Matthew P , Hampson Karen M , Mallen Edward AH 
Published: February 2022

AbstractPurposeTo determine whether accommodative microfluctuations (AMFs) are affected by the image resolution of the display type being observed. The effect of refractive error is also examined.MethodsTwenty participants, (10 myopes and 10 emmetropes) observed a target on four different displays: paper, smartphone, e‐reader and visual display unit screen (VDU), whilst their accommodative responses were measured using a continuous recording infrared autorefractor. The accommodative response and AMF measures comprising low frequency components (LFC), high frequency components (HFC) and the root mean square (RMS) of the AMFs were analysed.ResultsA significant increase in LFC power was observed for the paper stimulus when compared to the VDU and smartphone conditions. Myopes demonstrated a significantly higher LFC and mean accommodative response compared to emmetropes across the four displays. A significant difference in the mean AR between the displays with the lowest and highest resolution was found. A higher mean AR was found with higher resolution of the image. The HFC and RMS accommodation were not affected by display type.ConclusionThe mean accommodative response and the mean LFC power appear to respond differently depending on the type of display in use. Higher resolution devices showed a reduced lag of accommodation to the accommodative demand; however, this may cause a lead of accommodation in myopes for higher resolution display types.
The LONELY GUY gene family: from mosses to wheat, the key to the formation of active cytokinins in plants
Authors: Chen Lei , Jameson Geoffrey B. , Guo Yichu , Song Jiancheng , Jameson Paula E. 
Published: February 2022

SummaryLONELY GUY (LOG) was first identified in a screen of rice mutants with defects in meristem maintenance. In plants, LOG codes for cytokinin riboside 5′‐monophosphate phosphoribohydrolase, which converts inactive cytokinin nucleotides directly to the active free bases. Many enzymes with the PGGxGTxxE motif have been misannotated as lysine decarboxylases; conversely not all enzymes containing this motif are cytokinin‐specific LOGs. As LOG mutants clearly impact yield in rice, we investigated the LOG gene family in bread wheat. By interrogating the wheat (Triticum aestivum) genome database, we show that wheat has multiple LOGs. The close alignment of TaLOG1, TaLOG2 and TaLOG6 with the X‐ray structures of two functional Arabidopsis thaliana LOGs allows us to infer that the wheat LOGs 1‐11 are functional LOGs. Using RNA‐seq data sets, we assessed TaLOG expression across 70 tissue types, their responses to various stressors, the pattern of cis‐regulatory elements (CREs) and intron/exon patterns. TaLOG gene family members are expressed variously across tissue types. When the TaLOG CREs are compared with those of the cytokinin dehydrogenases (CKX) and glucosyltransferases (CGT), there is close alignment of CREs between TaLOGs and TaCKXs reflecting the key role of CKX in maintaining cytokinin homeostasis. However, we suggest that the main homeostatic mechanism controlling cytokinin levels in response to biotic and abiotic challenge resides in the CGTs, rather than LOG or CKX. However, LOG transgenics and identified mutants in rice variously impact yield, providing interesting avenues for investigation in wheat.
Tinea capitis with multiple isolates: The interaction of nature, animal and child
Authors: Porter Emma , Kanaan Ansam , Carty Kieran , Stapleton Patrick J. , Hay Roderick , Field Sinead 
Published: February 2022

AbstractTinea capitis is an infection of the scalp and hair commonly seen in the pediatric population. Detection of multiple dermatophytes is unusual, and true mixed infections have been rarely reported. Herein, we describe an 8‐year‐old girl with tinea capitis revealing three different dermatophyte isolates that highlight the clinical challenge posed by this phenomenon.
Vaccinated kindergartens: A community‐based bottom‐up initiative addressing vaccine hesitancy in Israel
Authors: Popper‐Giveon Ariela , Keshet Yael 
Published: February 2022

BackgroundVaccine hesitancy (VH) has grown over recent decades. While most of the strategies implemented to cope with VH are
top‐down interventions, the present article focuses on a unique community‐based bottom‐up initiative conducted in Israel: Mehusgan—the vaccinated kindergarten.ObjectiveThe objective of the study was to learn about the vaccinated kindergarten initiative: its implementation, benefits, and challenges as well as its broader potential impact.MethodologyDuring 2020, we conducted 13 semi‐structured in‐depth interviews with parents, kindergarten teachers and managers, and physicians.FindingsThe interviews revealed that parents are encouraged to complete the vaccination program as recommended; additional kindergartens join the initiative; and additional kindergartens become vaccinated.ConclusionsMehusgan is a unique and growing initiative that leads to vaccinated kindergartens and, therefore, contributes to public health. This case study can encourage other community‐based bottom‐up initiatives that seek to raise vaccination rates.