bluuebunny/crossref_metadata_2025_split huggingface dataset:
Professional–Collector Collaboration
Authors: Pitblado Bonnie L. , Rowe Matthew J. , Schroeder Bryon , Thomas Suzie , Wessman Anna 
Published: February 2022

AbstractThis article introduces the first of what will ultimately be two collections of case studies in archaeologist–responsible/responsive artifact collector collaboration. Focused on the United States, the articles in this issue of Advances in Archaeological Practice share the thoughts and experiences of archaeologists representing diverse employment sectors (compliance, agency, museum, and university), artifact collectors, and members of descendant communities. Research areas extend from California to Virginia and from Ohio to the Texas/Mexico border. The breadth of the writers' backgrounds and their focal regions reinforce the wide applicability of collaborative best practices. Every author explicitly treats two subjects: (1) the intersection of their work with the Society for American Archaeology's (SAA) recently published guidelines for ethical professional–collector collaboration, and (2) their own practical suggestions for establishing and nurturing those relationships. This introductory article provides an overview of each of the other contributions, notes how the contributions articulate with the SAA guidelines, and offers its own, mostly philosophical suggestions for prospective members of professional–collector collaborations.
Long Live Chairman Mao! Death, Resurrection, and the (Un)Making of a Revolutionary Relic
Authors: Tu Hang 
Published: February 2022

AbstractWhy does Mao's embalmed corpse continue to arouse powerful religious feelings among contemporary Chinese writers after the end of his rule, from fantasies of resurrection to yearnings for redemption? While extant scholarship focuses on the sociopolitical aspects of Mao's posthumous cult, this essay reveals the crucial role that literary narrative plays in the (un)making of Mao's quasi-religious appeal. Drawing on literary genres such as diary, memoir, science fantasy, and satirical fiction, I argue that the political theology of Mao can be read as a grand “political fiction” that linked the doubling of Mao's immortal body with the perpetual sovereignty of the Chinese Communist Party. However, even as literary narrative authorizes the political mythology of Mao, contemporary Chinese literature also demonstrates its capacity for ideological critique. My narrative begins with the party's controversial effort to sacralize Mao's biological remains, from the ritualized display of political sovereignty to the ambiguous allusion to religious miracle. Then I look at the bizarre resurrection of Mao's flesh in Liu Cixin's 劉慈欣 1989 science fiction novel China 2185. The story features a cybernetic uprising in the distant future, when a computer engineer breaks into the Mao mausoleum and “uploads” Mao's mind into cyberspace. Lastly, I draw on the satirical fictions of Yan Lianke 閻連科 and Chan Koonchung 陳冠中 to reveal the desacralizing impacts of neoliberal capitalism on the Maoist political religiosity.
Altered glutamate level and its association with working memory among patients with treatment-resistant schizophrenia (TRS): a proton magnetic resonance spectroscopy study
Authors: Huang Li-Chung , Lin Shih-Hsien , Tseng Huai-Hsuan , Chen Kao Chin , Abdullah Muhammad , Yang Yen Kuang 
Published: February 2022

AbstractBackgroundTreatment-resistant schizophrenia (TRS) and non-TRS may be associated with different dopaminergic and glutamatergic regulations. The concept of dysregulated glutamatergic concentrations in specific brain regions remains controversial. Herein, we aimed to assess (i) the distribution of the glutamatergic concentration in the brain, (ii) the association between working memory (WM) differences in TRS and non-TRS patients, and (iii) whether an alteration in the glutamate (Glu) level is associated with WM.MethodsThe participants included 38 TRS patients, 35 non-TRS patients, and 19 healthy controls (HCs), all of whom underwent 1.5-Tesla proton magnetic resonance spectroscopy of anterior cingulate cortex (ACC) and medial prefrontal cortex (MPFC). The ratios of glutamatergic neurometabolites to N-acetylaspartate + N-acetyl aspartylglutamate (NAAx) were calculated. Cognitive function was assessed using the Wechsler Adult Intelligence Scales, 4th Edition, which included the working memory index (WMI).ResultThe TRS patients had a higher glutamate + glutamine (Glx)/NAAx ratio compared to the non-TRS patients and HCs in the ACC, but this was not significantly different in the MPFC. WM was negatively correlated with Glx/NAAx in the ACC among the non-TRS patients, but not in the TRS patients or HCs.ConclusionsOur findings were consistent with most studies indicating that the glutamatergic concentration in the ACC plays important roles in the classification of TRS and cognition. Our results may provide potential evidence for predictors and treatment response biomarkers in TRS patients. Further research is needed to probe the value using the relationship between Glu and WM as a potential prognostic predictor of schizophrenia.
The role of care-giver and mental health for older adults with disabilities: a mixed-method study
Authors: Huang Shuoao , Zhao Qi , Liu Xiaoting , Jin Yanyan 
Published: February 2022

AbstractBecause of the exacerbation of population ageing, more family members are involved in the informal care-giving for older adults with disabilities to cater to their long-term care needs. As informal care-givers are associated with the mental health of the care recipient, this study, based on the theoretical framework of the Actor–Partner Effect, utilises a mixed method composed of quantitative and qualitative strategies to identify the relationship among gender and type of both care-giver and care recipient, and mental health of the recipient and explain its internal mechanism. In the quantitative research, ordinary least squares (OLS) regression results based on the basis of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) data corroborate the existence of actor and partner effects within the care-giving dyad. The qualitative analysis further explains the socially constructed differences in gender role, trust relationship and perception towards filial piety of adult care-givers playing their role in the emergence of the Actor–Partner Effect. Finally, this study proposes a developed Actor–Partner Effect analysis framework, advocating to destigmatise disability and construct social support networks for the older adults with disabilities who receive informal care to promote their mental health based on the reflection of socially constructed gender difference.
DISCRIMINABILITY AND PROTOTYPICALITY OF NONNATIVE VOWELS
Authors: Shinohara Yasuaki , Han Chao , Hestvik Arild 
Published: February 2022

AbstractThis study examined how discriminability and prototypicality of nonnative phones modulate the amplitude of the Mismatch Negativity (MMN) event-related brain potential. We hypothesized that if a frequently occurring (standard) stimulus is not prototypical to a listener, a weaker predictive memory trace will be formed and a smaller MMN will be generated for a phonetic deviant, regardless of the discriminability between the standard and deviant stimuli. The MMN amplitudes of Japanese speakers hearing the English vowels /æ/ and /ɑ/ as standard stimuli and /ʌ/ as a deviant stimulus in an oddball paradigm were measured. Although the English /æ/-/ʌ/ contrast was more discriminable than the English /ɑ/-/ʌ/ contrast for Japanese speakers, when Japanese speakers heard the /æ/ standard stimulus (i.e., less prototypical as Japanese /a/) and the /ʌ/ deviant stimulus, their MMN amplitude was smaller than the one elicited when they heard /ɑ/ as a standard stimulus (i.e., more prototypical as Japanese /a/) and /ʌ/ as a deviant stimulus. The prototypicality of the standard stimuli in listeners’ phonological representations modulates the MMN amplitude more robustly than does the discriminability between standard and deviant stimuli.
Avoidable hospitalization after family physician and rural health insurance: interrupted time series and regression analyses, Tehran province, Iran
Authors: Salavati Sedigheh , Rashidian Arash , Hajimahmoodi Hanan , Ememgholipour Sara , Varahrami Vida , Khodayarimoez Elham 
Published: February 2022

Abstract

Background
Studying the effect of primary health care development when simultaneously implemented with health insurance schemes assesses effectiveness and use of health care services and gives us insight on how to develop such interventions in different countries.

Aim
To analyze the impact of health insurance and the family physician program on total hospitalizations, and the relation between avoidable hospitalizations and access to family physicians among the rural population in Iran.

Methods
We conducted an interrupted time series (ITS) analysis of monthly hospitalization rates between the years of 2003 and 2014 to assess the immediate and gradual effects of these reforms on total hospitalization rates in the rural areas of Tehran province. In addition, we used a sample of 22 570 hospitalizations between 2006 and 2013 to develop a logistic regression model to measure the association between access to a family physician and avoidable hospitalizations.

Findings
ITS analysis showed that there was an immediate increase of about 1.96 hospitalizations per 1000 inhabitants (P<0.0001, CI=1.58, 2.34) hospitalization rates after the reforms. This was followed by a significant increase of about 0.089 per 1000 inhabitants (P<0.0001, CI=0.07, 0.1). Hospitalization increase continued up to four years after the policy implementation. Following that, hospitalization rates decreased among the rural population (a decrease of 0.066 per 1000, P<0.0001, CI=−0.084, −0.048). Studying the hospitalizations that occurred between 2006 and 2013 showed that there were 4106 avoidable hospitalizations from among a sample of 22 570 hospitalizations. Results of logistic regression models including gender, age and access to family physician variables showed that there was no statistical relation between access to a family physician and avoidable hospitalizations.

Conclusion
Reforms had access effect and caused increased hospital services uses in people with unmet needs. Also the reforms did not decrease avoidable hospitalizations, and therefore had no efficiency effect.
Improving Channel Hydrological Connectivity in Coastal Hydrodynamic Models With Remotely Sensed Channel Networks
Authors: Zhang Xiaohe , Wright Kyle , Passalacqua Paola , Simard Marc , Fagherazzi Sergio 
Published: February 2022

AbstractCoastal wetlands are nourished by rivers and periodical tidal flows through complex, interconnected channels. However, in hydrodynamic models, channel dimensions with respect to model grid size and uncertainties in topography preclude the correct propagation of tidal and riverine signals. It is therefore crucial to enhance channel geomorphic connectivity and simplify sub‐channel features based on remotely sensed networks for practical computational applications. Here, we utilize channel networks derived from diverse remote sensing imagery as a baseline to build a ∼10 m resolution hydrodynamic model that covers the Wax Lake Delta and adjacent wetlands (∼360 km2) in coastal Louisiana, USA. In this richly gauged system, intensive calibrations are conducted with 18 synchronous field‐observations of water levels taken in 2016, and discharge data taken in 2021. We modify channel geometry, targeting realism in channel connectivity. The results show that a minimum channel depth of 2 m and a width of four grid elements (approximatively 40 m) are required to enable a realistic tidal propagation in wetland channels. The optimal depth for tidal propagation can be determined by a simplified cost function method that evaluates the competition between flow travel time and alteration of the volume of the channels. The integration of high spatial‐resolution models and remote sensing imagery provides a general framework to improve models performance in salt marshes, mangroves, deltaic wetlands, and tidal flats.
Experimental evaluation of ecological principles to understand and modulate the outcome of bacterial strain competition in gut microbiomes
Authors: Segura Munoz Rafael R , Mantz Sara , Martínez Ines , Li Fuyong , Schmaltz Robert J , Pudlo Nicholas A , Urs Karthik , Martens Eric C , Walter Jens , Ramer-Tait Amanda E 
Published: February 2022

Abstract
It is unclear if coexistence theory can be applied to gut microbiomes to understand their characteristics and modulate their composition. Through experiments in gnotobiotic mice with complex microbiomes, we demonstrated that strains of Akkermansia muciniphila and Bacteroides vulgatus could only be established if microbiomes were devoid of these species. Strains of A. muciniphila showed strict competitive exclusion, while B. vulgatus strains coexisted but populations were still influenced by competitive interactions. These differences in competitive behavior were reflective of genomic variation within the two species, indicating considerable niche overlap for A. muciniphila strains and a broader niche space for B. vulgatus strains. Priority effects were detected for both species as strains’ competitive fitness increased when colonizing first, which resulted in stable persistence of the A. muciniphila strain colonizing first and competitive exclusion of the strain arriving second. Based on these observations, we devised a subtractive strategy for A. muciniphila using antibiotics and showed that a strain from an assembled community can be stably replaced by another strain. By demonstrating that competitive outcomes in gut ecosystems depend on niche differences and are historically contingent, our study provides novel information to explain the ecological characteristics of gut microbiomes and a basis for their modulation.
The E3 ubiquitin ligase, FBXW5, promotes the migration and invasion of gastric cancer through the dysregulation of the Hippo pathway
Authors: Yao Yangyang , Liu Zhen , Huang Shanshan , Huang Chunye , Cao Yuan , Li Li , Guo Hui , Liu Fenfen , Huang Shipeng , Liao Quan , He Xin , Chen Jun , Li Junhe , Xiang Xiaojun , Xiong Jianping , Deng Jun 
Published: February 2022

AbstractF-box and WD repeat domain-containing 5 (FBXW5), with WD40 repeats, can bind to the PPxY sequence of the large tumor suppressor kinases 1/2 (LATS1/2) kinase domain, resulting in ubiquitination. Ubiquitination and the subsequent degradation of LATS1/2 abrogate the Hippo pathway and worsen gastric cancer (GC). However, the effects and molecular mechanisms of FBXW5 in GC remain unexplored. To elucidate the clinical significance of FBXW5, immunohistochemistry was conducted to reveal the positive correlation between FBXW5 expression and lymph node metastasis (p < 0.001) and TNM stage (training cohort: p = 0.018; validation cohort: p = 0.001). Further, patients with high FBXW5 expression were found to have poor prognosis (training cohort: log-rank p = 0.020; validation cohort: log-rank p = 0.025). Cell experiments revealed the promoting effects of FBXW5 on the proliferation, invasion, metastasis, and chemoresistance of GC cells. Blocking LATS1-YAP1 leads to the loss of FBXW5-mediated regulation of the Hippo pathway and partial functions. Further, co-immunoprecipitation and in vivo ubiquitination assays revealed the interaction between FBXW5 and LATS1, which promoted the ubiquitination and degradation of LATS1. Based on mouse xenograft assays, FBXW5 silencing attenuated the growth of subcutaneous tumor xenografts. Altogether, FBXW5 was found to inactivate the Hippo signaling pathway by enhancing LATS1 ubiquitination and degradation, which promoted the invasion, metastasis, and drug resistance of GC cells.
Lipid nanoparticle-encapsulated mRNA antibody provides long-term protection against SARS-CoV-2 in mice and hamsters
Authors: Deng Yong-Qiang , Zhang Na-Na , Zhang Yi-Fei , Zhong Xia , Xu Sue , Qiu Hong-Ying , Wang Tie-Cheng , Zhao Hui , Zhou Chao , Zu Shu-Long , Chen Qi , Cao Tian-Shu , Ye Qing , Chi Hang , Duan Xiang-Hui , Lin Dan-Dan , Zhang Xiao-Jing , Xie Liang-Zhi , Gao Yu-Wei , Ying Bo , Qin Cheng-Feng 
Published: February 2022

AbstractMonoclonal antibodies represent important weapons in our arsenal to against the COVID-19 pandemic. However, this potential is severely limited by the time-consuming process of developing effective antibodies and the relative high cost of manufacturing. Herein, we present a rapid and cost-effective lipid nanoparticle (LNP) encapsulated-mRNA platform for in vivo delivery of SARS-CoV-2 neutralization antibodies. Two mRNAs encoding the light and heavy chains of a potent SARS-CoV-2 neutralizing antibody HB27, which is currently being evaluated in clinical trials, were encapsulated into clinical grade LNP formulations (named as mRNA-HB27-LNP). In vivo characterization demonstrated that intravenous administration of mRNA-HB27-LNP in mice resulted in a longer circulating half-life compared with the original HB27 antibody in protein format. More importantly, a single prophylactic administration of mRNA-HB27-LNP provided protection against SARS-CoV-2 challenge in mice at 1, 7 and even 63 days post administration. In a close contact transmission model, prophylactic administration of mRNA-HB27-LNP prevented SARS-CoV-2 infection between hamsters in a dose-dependent manner. Overall, our results demonstrate a superior long-term protection against SARS-CoV-2 conferred by a single administration of this unique mRNA antibody, highlighting the potential of this universal platform for antibody-based disease prevention and therapy against COVID-19 as well as a variety of other infectious diseases.
Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits
Authors: Heintz Tristan G. , Hinojosa Antonio J. , Dominiak Sina E. , Lagnado Leon 
Published: February 2022

AbstractSensory processing in the cortex adapts to the history of stimulation but the mechanisms are not understood. Imaging the primary visual cortex of mice we find here that an increase in stimulus contrast is not followed by a simple decrease in gain of pyramidal cells; as many cells increase gain to improve detection of a subsequent decrease in contrast. Depressing and sensitizing forms of adaptation also occur in different types of interneurons (PV, SST and VIP) and the net effect within individual pyramidal cells reflects the balance of PV inputs, driving depression, and a subset of SST interneurons driving sensitization. Changes in internal state associated with locomotion increase gain across the population of pyramidal cells while maintaining the balance between these opposite forms of plasticity, consistent with activation of both VIP->SST and SST->PV disinhibitory pathways. These results reveal how different inhibitory microcircuits adjust the gain of pyramidal cells signalling changes in stimulus strength.
Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly
Authors: Xu Yong , Maya-Martinez Roberto , Guthertz Nicolas , Heath George R. , Manfield Iain W. , Breeze Alexander L. , Sobott Frank , Foster Richard , Radford Sheena E. 
Published: February 2022

AbstractHuman islet amyloid polypeptide (hIAPP) self-assembles into amyloid fibrils which deposit in pancreatic islets of type 2 diabetes (T2D) patients. Here, we applied chemical kinetics to study the mechanism of amyloid assembly of wild-type hIAPP and its more amyloidogenic natural variant S20G. We show that the aggregation of both peptides involves primary nucleation, secondary nucleation and elongation. We also report the discovery of two structurally distinct small-molecule modulators of hIAPP assembly, one delaying the aggregation of wt hIAPP, but not S20G; while the other enhances the rate of aggregation of both variants at substoichiometric concentrations. Investigation into the inhibition mechanism(s) using chemical kinetics, native mass spectrometry, fluorescence titration, SPR and NMR revealed that the inhibitor retards primary nucleation, secondary nucleation and elongation, by binding peptide monomers. By contrast, the accelerator predominantly interacts with species formed in the lag phase. These compounds represent useful chemical tools to study hIAPP aggregation and may serve as promising starting-points for the development of therapeutics for T2D.
Spatial distribution modulation of mixed building blocks in metal-organic frameworks
Authors: Jeong Seok , Seong Junmo , Moon Sung Wook , Lim Jaewoong , Baek Seung Bin , Min Seung Kyu , Lah Myoung Soo 
Published: February 2022

AbstractThe placement of mixed building blocks at precise locations in metal–organic frameworks is critical to creating pore environments suitable for advanced applications. Here we show that the spatial distribution of mixed building blocks in metal–organic frameworks can be modulated by exploiting the different temperature sensitivities of the diffusion coefficients and exchange rate constants of the building blocks. By tuning the reaction temperature of the forward linker exchange from one metal–organic framework to another isoreticular metal–organic framework, core–shell microstructural and uniform microstructural metal–organic frameworks are obtained. The strategy can be extended to the fabrication of inverted core–shell microstructures and multi-shell microstructures and applied for the modulation of the spatial distribution of framework metal ions during the post-synthetic metal exchange process of a Zn-based metal–organic framework to an isostructural Ni-based metal–organic framework.
Targeting ferroptosis protects against experimental (multi)organ dysfunction and death
Authors: Van Coillie Samya , Van San Emily , Goetschalckx Ines , Wiernicki Bartosz , Mukhopadhyay Banibrata , Tonnus Wulf , Choi Sze Men , Roelandt Ria , Dumitrascu Catalina , Lamberts Ludwig , Dams Geert , Weyts Wannes , Huysentruyt Jelle , Hassannia Behrouz , Ingold Irina , Lele Suhas , Meyer Evelyne , Berg Maya , Seurinck Ruth , Saeys Yvan , Vermeulen An , van Nuijs Alexander L. N. , Conrad Marcus , Linkermann Andreas , Rajapurkar Mohan , Vandenabeele Peter , Hoste Eric , Augustyns Koen , Vanden Berghe Tom 
Published: February 2022

AbstractThe most common cause of death in the intensive care unit (ICU) is the development of multiorgan dysfunction syndrome (MODS). Besides life-supporting treatments, no cure exists, and its mechanisms are still poorly understood. Catalytic iron is associated with ICU mortality and is known to cause free radical-mediated cellular toxicity. It is thought to induce excessive lipid peroxidation, the main characteristic of an iron-dependent type of cell death conceptualized as ferroptosis. Here we show that the severity of multiorgan dysfunction and the probability of death are indeed associated with plasma catalytic iron and lipid peroxidation. Transgenic approaches underscore the role of ferroptosis in iron-induced multiorgan dysfunction. Blocking lipid peroxidation with our highly soluble ferrostatin-analogue protects mice from injury and death in experimental non-septic multiorgan dysfunction, but not in sepsis-induced multiorgan dysfunction. The limitations of the experimental mice models to mimic the complexity of clinical MODS warrant further preclinical testing. In conclusion, our data suggest ferroptosis targeting as possible treatment option for a stratifiable subset of MODS patients.