bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of ZnO and CuO nanoparticles via Sol gel method and Its Characterization by using XRD and FT-IR Analysis
Authors: Patel Monika , Mishra Sunita , Verma Ruchi , Shikha Deep 
Published: January 2022

Abstract
Nanotechnology is a completely unique branch of technology that offers with substances in a very small size between (1-100 nm) with various crystal shapes which include spherical nanoparticles, flower shaped, Nano rods, Nano ribbons, and Nano platelets. Metals have ability to produce large number of oxides. These metal oxides play an major role in many areas of chemistry, physics, material science and food science. In this research, Zinc Oxide (ZnO) and Copper (II) oxide nanoparticles were synthesized via sol-gel process using zinc nitrate and copper (II) nitrate as precursor respectively. The characterization of CuO and ZnO nanoparticles was done by using various techniques. X-ray Diffraction (XRD) indicates the crystallinity and crystal size of CuO and ZnO nanoparticle. Fourier transform infrared spectroscopy (FT-IR) was used to get the infrared spectrum of the sample indicating composition of the sample which contains various functional groups. XRD result shows the particle size of CuO at highest peak 29.40140 was 61.25 nm and the particle size of ZnO at highest peak 36.24760 was 21.82 nm. FT-IR spectra peak at 594.56 cm-1 indicated characteristic absorption bands of ZnO nanoparticles and the broad band peak at 3506.9 cm-1 can be attributed to the characteristic absorption of O-H group. The analysis of FT-IR spectrum of CuO shows peaks at 602.09, 678.39, and 730.19cm−1 which refer to the formation of CuO. A broad absorption peak noticed at 3308.2 cm−1 attributed to O–H stretching of the moisture content.
Health Committees as Vehicles for Democratic Governance in Health Systems: Lessons from Selected Health Unit Management Committees in Uganda
Authors: Mulumba Moses , Roelens Kristien , London Leslie , Ruano Lorena 
Published: January 2022

Abstract
Introduction: For over forty years, community participation has been a central component of a well-functioning health system. Despite its important role there are many difficulties in defining and understanding community participation as part of governance. Through a case study of selected health unit management committees in Uganda, this paper demonstrates that these committees can be structures for community participation and vehicles for democratic governance in health systems that advance health equity. Guided by the theoretical underpinnings of deliberative democracy the paper evaluates the performance of health unit management committees as a mechanism for citizen participation in health systems. Methods: This paper uses a qualitative, case-study methodology. Through an in-depth look at the health unit management committees of Kiboga and Kyankwanzi in Uganda, the study considered these as examples of structures for democratic community participation in health system. The study undertook literature review on the theories of deliberative democracy and human rights principles, and this provided the theoretical underpinnings of the study. Findings: Our findings underscore that community participation in health systems through health unit management committees ought to be grounded in the principles of deliberative democracy. The core of deliberative democracy is considered to be authentic deliberation and consensus decision-making, which can happen in both direct and representative democracies, giving rise to the notions of populist and elitist deliberative democracy, respectively. As such, a balance needs to be struck between the competitive notions of democracy and the public health requirements of inclusive and direct participation of communities in decision making processes on matters that affect their health. Conclusions: Community participation in the health sector in Uganda hinges on health unit management committees at the lower service provision points. These HUMCs are also perceived as vehicles to strengthen health governance through realizing the right to health of the communities. However, these have been established without attention to investing in capacity building needed to enable them to exercise community voice in the health system.
Prediction of distant metastasis of spinal and pelvic osteosarcoma by constructing and validating nomogram:a retrospective study based on SEER database
Authors: Lin Yu , Wang Zhenyu , Chen Gang , Liu Wenge 
Published: January 2022

Abstract
Background:Spinal and pelvic osteosarcoma is a rare type of all osteosarcomas,and distant metastasis is an important factor for poor prognosis of this disease. There are no similar studies on prediction of distant metastasis of spinal and pelvic osteosarcoma. We aim to construct and validate a nomogram to predict the risk of distant metastasis of spinal and pelvic osteosarcoma.Methods:We collected the data on patients with spinal and pelvic osteosarcoma from the Surveillance, Epidemiology, and End Results(SEER) database retrospectively. The Kaplan-Meier curve was used to compare differences in survival time between patients with metastasis and non-metastasis. Total patients were randomly divided into training cohort and validation cohort. The risk factor of distant metastasis were identified via the least absolute shrinkage and selection operator(LASSO) regression and multivariate logistic analysis. The nomogram we constructed were validated internally and externally by C-index, calibration curves,receiver operating characteristic(ROC) curve and Decision curve analysis (DCA).Results:The Kaplan-Meier curve showed that the survival time of non-metastatic patients was longer than that of metastatic patients(P＜0.001).All patients(n=358) were divided into training cohort(n=269) and validation cohort(n=89).The LASSO regression selected five meaningful variables in the training cohort. The multivariate logistic regression analysis demonstrated that surgery(yes,OR=0.175, 95%CI=0.095-0.321,p=0.000) was the independent risk factors for distant metastasis of patients with spinal and pelvic osteosarcoma. The C-index and calibration curves showed the good agreement between the predicted results and the actual results. The area under the receiver operating characteristic curve(AUC) values were 0.748(95%CI=0.687-0.817) and 0.758(95%CI=0.631-0.868) in the training and validation cohorts respectively. The DCA showed that the nomogram has a good clinical usefulness and net benefit.Conclusion:No surgery is the independent risk factor of distant metastasis of spinal and pelvic osteosarcoma. The nomogram we constructed to predict the probability of distant metastasis of patients with spinal and pelvic osteosarcoma is reliable and effective by internal and external verification.
Electrocardiographic Features in SCN5A Mutation-Positive Patients with Brugada and Early Repolarization Syndromes: A Systematic Review and Meta-Analysis
Authors: Radford Danny , Chou Oscar Hou In , Bazoukis George , Letsas Konstantinos , Liu Tong , Tse Gary , Lee Sharen 
Published: January 2022

Abstract
Background: Early repolarization syndrome (ERS) and Brugada syndrome (BrS) are both J-wave syndromes. Both can involve mutations in the SCN5A gene but may exhibit distinct electrocardiographic (ECG) differences. The aim of this systematic review and meta-analysis is to investigate possible differences in ECG markers between SCN5A positive patients with ERS and BrS. Methods: PubMed and Embase, were searched from their inception to October 20th, 2021 for human studies containing the search terms “SCN5A” and “variant” and “early reporlarization” or “Brugada”, with no language restrictions. Results: A total of 328 studies were identified. After full text screening, 12 studies met our inclusion criteria and were included in this present study. 104 ERS patients (mean age: 30.86 ±14.45) and 2000 BrS patients (mean age: 36.17 ±11.39) were studied. Our meta-analysis found that ERS patients had a significantly lower heart rate (standardized mean difference [SMD]a= 14.69, 95% confidence interval [CI] = 21.43, 7.94, P = 0.0001), shorter QRS duration (SMD = 13.90, 95% CI = 17.16, 10.65, P = 0.0001) and shorter QTc [corrected QT interval] (SDM = 21.52, 95% CI = 33.77, 9.26, P = 0.0006) than BrS patients. Conclusion: BrS patients with positive SCN5A mutations exhibited prolonged QRS, indicating conduction abnormalities, whereas ERS patients with positive SCN5A mutations showed normal QRS. By contrast, whilst QTc intervals were longer in BrS than in ERS SCN5A positive patients, they were within normal limits. Further studies are needed to examine the implications of these findings for arrhythmic risk stratification.
Characteristics of two complex rock and glacier avalanches and RAMMS simulation of a long-runout disaster in the Sedongpu Basin of the Yarlung Zangbo River downstream in October 2018, Tibet, China
Authors: Zhang Tiantian , Yin Yueping , Li Bin , Gao Yang , Wang Meng 
Published: January 2022

Abstract
On October 17 and 29, 2018, two rock and glacier avalanches occurred on the western slope of the Sedongpu Basin upstream of the Yarlung Zangbo River in the Tibetan Plateau, forming the disaster chains and causing damage to many bridges and roads. Based on the comparative analysis of multiple pre-and post-remote sensing images, the initial sliding body, which was composed of rock and glacial material, was located on a steep slope above an elevation of 6000 m. Under the coupling effect of multiple factors such as gravity, rainfall, and weather changes, the initial sliding body detached from the source zone and then transformed into a debris flow after impact and fragmentation. The debris flow traveled downstream and scraped loose glacial till in its path, causing the volume of the sliding body to increase. In addition, the debris flow traveled 10 km under low frictional resistance, as a result of the lubrication via early rainfall and glacial meltwater. Eventually, the debris flow rushed out onto the valley floor, forming a landslide dam and blocking the Yarlung Zangbo River. The deposit volumes on October 17 and 29 were 20.4 million m3 and 10.1 million m3, respectively, with a total mean thickness of ~22m. This study provides an insight into the dynamic process as they unfolded, through multitemporal satellite imagery and numerical simulation. Furthermore, we also discuss the potential cause of rock/ice avalanche and disaster scenarios, as well as the tendency of the rock and glacier avalanches are discussed.
The Activation of Residual Dormant Follicles by Human Chorionic Gonadotropin (HCG) in Vivo: a Novel Treatment for Premature Ovarian Insufficiency
Authors: Chen Xiao , Yu Keda , Liu Hong , Chen Chen , Yu Yuanyuan , Hu Yingying , Li Youjiang , xu Jian 
Published: January 2022

Abstract
BackgroundWith the influence of factors such as ovarian surgery, high-dose radiotherapy and chemotherapy, environmental degradation, and bad living habits, the occurrence of premature ovarian insufficiency(POI) is getting younger and younger, and many young women's ovaries have entered the aging stage earlier. While many studies have investigated the patients with POI, which is still a challenge in reproductive medicine as the treatments available now are not ideal. POI patients have varying amounts of residual dormant follicles in the ovaries. Therefore, it is critical to further our understanding of primordial follicle activation in order to treat.This study aimed to investigate the activation of residual follicles in POI patients with injection of HCG, whether they could obtain embryos and become pregnant.Methods Four patients with POI were pretreated with dehydroepiandrosterone, Coenzyme Q10, estrogen and medroxyprogesterone. The prescribed amounts of estrogen and medroxyprogesterone were adjusted to maintain the level of FSH at ˂15 mIU/ml and the level of LH˂10 mIU/ml. When the treatments failed to induce the appearance of follicles after 3 months, the patients received treatment with 10000 IU of HCG. Results The residual dormant follicles in POI patients can be activated using our approach to obtain embryos and conceive by injection of HCG. ConclusionsPOI patients may conceive their own genetic children by activating dormant follicles in vivo. These findings may represent a new simple and feasible solution for the treatment of patients with POI to conceive their own genetic children.
Clinicopathological Characteristics and Prognostic Factors in Axial Chondroblastomas: A Retrospective Analysis of 61 Cases and Comparison with Extra-Axial Chondroblastomas
Authors: Zheng Bo-Wen , Zheng Bo-Yv , Niu Hua-Qing , Wang Xiao-Bin , Lv Guo-Hua , Li Jing , Zou Ming-Xiang , Ouyang Zhi-Hua 
Published: January 2022

Abstract
Background
The clinical characteristics and prognostic factors of axial chondroblastoma (ACB) are still poorly understood.
Purpose
To characterize clinicopathological characteristics in a large ACB cohort and investigate their correlation with survival. We also sought to compare these results with extra-axial CB (EACB).
Methods
Our institution's local database was retrospectively reviewed and included a total of 132 CB patients, including 61 ACB patients and 71 EACB patients. Immunohistochemistry was used to assess the expression levels of Vimentin (Vim), S100, and cytokeratin (CK) on tumor cells in 132 tissue specimens.
Results
Overall, ACB and EACB had similar characteristics, except for older age and tumor size, as well as higher Vim expression, incidence of surrounding tissue invasion and postoperative sensory or motor dysfunction. Whereas wide resection and absence of invasion of surrounding tissues were consistently associated with favorable survival in the ACB and EACB cohorts in univariate analysis, most parameters showed differential prognostic significance between the 2 groups. Significant prognostic factors for local recurrence-free survival in multivariate analysis included the type of resection and chicken-wire calcification in the ACB cohort. Multivariate analysis of overall survival demonstrated that the type of resection was a significant predictor in the ACB cohort, whereas the type of resection and postoperative sensory or motor dysfunction were predictive of overall survival in the EACB group.
Conclusion
These data suggest that there may be distinct biological behaviors between ACB and EACB and may provide useful information to better understand the prognostic characteristics of patients with ACB and to improve outcome prediction in patients with ACB.
Thermophilic and non-thermophilic Campylobacter species Emits Distinct Volatile Organic Compounds in Different Culture Media and Growth Phases
Authors: Santos Filipe Magnum Silva Dos , Low Kah Hin , Chai Lay Ching 
Published: January 2022

Abstract
Bacteria emits a multitude of volatile organic compounds (VOCs) into the headspace as a mean of interactions with the environments, as well as intra- and interkingdom communication for survival and persistence in the nature and within their hosts. Campylobacter, which is often found in poultry and ruminants, has shown great persistence in aquatic environments, making it one of the world's most dangerous foodborne pathogens, killing thousands of people annually. In this study, the VOCs emitted by both thermophilic (C. jejuni, C. coli and C. lari) and non-thermophilic Campylobacter (C. fetus) of clinical concerns, impacted by nutrients composition (media) and growth phase were identified. Most thermophilic Campylobacter were shown to release volatile alcohols and ketones (1s,4R,7R,11R-1,3,4,7-Tetramethyltricyclo [5.3.1.0(4,11)] undec-2-en-8-one and Isophorone) during early stationary and stationary phases using active sampling with active charcoal adsorbent and GC-MS analysis. C. jejuni cultured in the Brain Heart Infusion had 1-Heptadecanol in its headspace gas, but not in Bolton Broth. The non-thermophilic C. fetus did not produce alcohols or ketones, but rather a variety of unidentified chemicals that will require further investigation in the future. Overall, PCA analysis revealed that the five Campylobacter strains studied created distinct volatilomes, allowing for future Campylobacter identification based on VOCs.
Gut-derived Metabolites Influence Neurodevelopmental Gene Expression and Wnt Signalling Events in a Germ-free Zebrafish Model
Authors: Raay Terry Van , Rea Victoria , Bell Ian 
Published: January 2022

Abstract
Background : Small molecule metabolites produced by the microbiome are known to be neuroactive and are capable of directly impacting the brain and central nervous system, yet there is little data on the contribution of these metabolites to the earliest stages of neural development and neural gene expression. Here, we explore the impact of deriving zebrafish embryos in the absence of microbes on early neural development as well as investigate whether any potential changes can be rescued with treatment of metabolites derived from the zebrafish gut microbiota. Results : Overall, we did not observe any gross morphological changes between treatments but did observe a significant decrease in neural gene expression in embryos raised germ-free, which was rescued with the addition of zebrafish metabolites. Specifically, we identified 354 genes significantly down regulated in germ-free embryos compared to conventionally raised embryos via RNA-Seq analysis. Of these, 42 were rescued with a single treatment of zebrafish gut-derived metabolites to germ-free embryos. Gene ontology analysis revealed that these genes are involved in prominent neurodevelopmental pathways including transcriptional regulation and Wnt signalling. Consistent with the ontology analysis, we found alterations in the development of Wnt dependent events which was rescued in the germ-free embryos treated with metabolites. Conclusions : These findings demonstrate that gut-derived metabolites are in part responsible for regulating critical signalling pathways in the brain, especially during neural development.
Cyclone Amphan effects on the copepods of Ganges estuary
Authors: Paul Sourav , Karan Samya , Bhattacharya Bhaskar Deb 
Published: January 2022

Abstract
Tropical cyclones are increasingly affecting the estuarine communities. Impacts of category-5 tropical cyclone Amphan (landfall on 20 May 2020 near Ganges estuary mouth) on the copepod community of Muriganga section of Ganges estuary was studied by sampling the copepod assemblages before (February to December 2019), shortly after (31 May to 12 June 2020) and post (September to November 2020) cyclone. Hypothesis was shortly after Amphan a relatively homogenous community consists of a few estuarine specialist copepods would succeed but within months that community would be replaced by a heterogenous one but those estuarine specialists would continue their dominance. Shortly after Amphan, species richness declined but the recovery process completed within months led by herbivorous Paracalanus parvus, omnivorous Bestiolina similis, Acartia spinicauda, Acartiella tortaniformis, and carnivorous Oithona brevicornis. Spatial homogeneity of the community that prevailed in Muriganga in pre-Amphan and shorty after Amphan was lost in post-Amphan. Community composition changed from pre- to shortly after to post-Amphan. Unilateral dominance of B. similis observed in pre-Amphan was challenged by P. parvus, A. spinicauda, A. tortaniformis and O. brevicornis shortly after Amphan and in post-Amphan. Acartia spinicauda proliferated shortly after Amphan and co-dominated the estuary along with A. tortaniformis but the latter replaced the former in post-Amphan. Copepods did rebuild their community within a few months from Amphan but experienced rearrangements of species composition, abundance, dominance hierarchy and feeding guilds, which may strain benthic-pelagic linkages of Ganges estuary so shall be monitored regularly by coastal institutions following uniform methods and best practises.
Unintended consequences of patient online access to health records: a qualitative study in UK primary care
Authors: Turner Andrew , Morris Rebecca , McDonagh Lorraine , Hamilton Fiona L. , Blake Sarah , Farr Michelle , Stevenson Fiona , Banks Jon , Atherton Helen , Rakhra Dylan , Lasseter Gemma , Feder Gene , Ziebland Sue , Hyde Emma , Powell John , Horwood Jeremy 
Published: January 2022

Abstract

BackgroundHealth systems around the world are seeking to harness digital tools to promote patient autonomy and increase the efficiency of care. One example of this policy in England is online patient access to full medical records in primary care. Since April 2019, all NHS England patients have had the right to access their full medical record prospectively, and full record access has been the “default position” since April 2020.AimTo identify and understand the unintended consequences of online patient access their medical record.Design and SettingQualitative interview study in 10 general practices in South West and North West England.MethodSemi-structured individual interviews with 13 patients and 16 general practice staff with experience of patient online access to health records.ResultsOnline access generated unintended consequences that negatively impacted patients’ understanding of their health care, for example patients discovering surprising information or information that was difficult to interpret. Online access impacted GPs’ documentation practices, such as when GPs pre-emptively attempted to minimise potential misunderstandings to aid patient understanding of their health care, in other cases, negatively impacting the quality of the records and patient safety when GPs avoided documenting their speculations or concerns. Contrary to assumptions that practice workload would be reduced, online access introduced extra work, such as managing and monitoring access and taking measures to prevent possible harm to patients.ConclusionThe unintended consequences described by both staff and patients show that to achieve the intended consequences set out in NHS policy additional work is necessary to prepare records for sharing and prepare patients about what to expect. It is crucial that practices are adequately supported and resourced to manage the unintended consequences of online access now that it is the default position.
Open defecation: risk factors for adverse outcomes in Indonesia
Authors: Irawaty Dian Kristiani , Utomo Wahyu 
Published: January 2022

Abstract
The increasing number of Indonesian population has caused serious issue of open defecation. Indonesia ranks the second large of open defecation prevalence in the world, after India. Human’s excrement was disposed in trench, drain, terrace, grassland, backwoods, forest, river, lake or other open spaces, thus, contaminates the water system. Open defecation can lead to the increasing risk of transmission of water-boene diseases of child morbidity in Indonesia. This study aimed at exploring different socio-economic and demographic factors of Indonesians who practice open defecation. Data were obtained from 49,627 female respondents of the 2017 Indonesia Demographic and Health Survey. The data were examined utilizing descriptive and logistic regression. The results reveal that the practice of open defecation is significantly influenced by place of residence, household’s wealth quintile, and household’s water supply. The findings suggest the needs for toilet construction and water supply sustainability in public area as well as in poor neighbourhood to eliminate open defecation in the country.