bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retention in treatment and therapeutic adherence: How are these associated with therapeutic success? An analysis using real‐world data
Authors: Dacosta‐Sánchez Daniel , González‐Ponce Bella M. , Fernández‐Calderón Fermín , Sánchez‐García Manuel , Lozano Oscar M. 
Published: June 2022

AbstractIntroductionTreatment retention and adherence are used as outcomes in numerous randomized clinical trials and observational studies conducted in the addiction field. Although usual criteria are 3/6 months of treatment retention or number of sessions attended, there is not a methodological support for conclusions using these criteria. This study analyzed the usefulness of retention and adherence to predict therapeutic success.MethodsRetrospective observational study using real‐world data from electronic health records of 11,907 patients in treatment diagnosed with cocaine, alcohol, cannabis and opiate use disorders or harmful use.ResultsModerate effect size relations were found between the different type of clinical discharge and months in retention (η2 = 0.12) and proportion of attendance (η2 = 0.10). No relationship was found with the number of sessions attended. Using cut‐off points (i.e., 3 or 6 months in treatment or attending 6 therapy sessions) worsens the ability to predict the type of discharge.Discussions/ConclusionTreatment retention and adherence are indicators moderately related to therapeutic success. Research using these indicators to assess the effectiveness of therapies should complement their results with other clinical indicators and quality of life measures.
Post‐COVID‐19 functional limitations in hospitalized patients and associated risk factors: A 3‐month follow‐up study
Authors: Bayat Masumeh , Raeissadat Seyed Ahmad , Lashgari Shervin , Bolandnazar Najmeh Sadat , Taheri Seyed Nima , Soleimani Mohammad 
Published: June 2022

AbstractBackground and PurposeMany patients experience post‐COVID‐19 functional limitations. This study aimed to monitor the functional improvement of patients over 3 months of follow‐up and determine the risk factors.MethodsThis prospective cohort study evaluated 100 hospitalized patients who recovered from COVID‐19 infection. The mean age was 53.2 ± 13.1 years. Fifty‐nine had at least one comorbid condition. The mean lengths of the hospital and ICU stays were 7.8 ± 3.3 and 5.3 ± 2.5 days, respectively. The functional status of the patients was evaluated using functional independence measure (FIM) and post‐COVID‐19 functional status (PCFS) questionnaires at four time‐points of discharge, 1 week, 1 month, and 3 months after discharge.ResultsMean FIM score was 107.2 ± 17.4 at the time of discharge, 113.3 ± 14.9 at 1 week, 120.3 ± 10.2 at 1 month, and 124.3 ± 6.4 at 3 months after discharge (p < 0.001). The PCFS score was 2.71 ± 1.25 at discharge, 2.09 ± 1.3 at 1 week, 1.14 ± 1.1 at 1 month, and 0.64 ± 0.59 at 3 months after discharge (p < 0.001). Female sex, older age, and the lengths of hospital and ICU stays were negatively correlated with the functional status score.DiscussionPost‐COVID‐19 functional limitations are observed in hospitalized patients and improve over 3 months after discharge. Female sex, older age, longer hospital, and ICU stays are risk factors that negatively impact functional status.
Polysaccharides of Brassica rapa L. attenuate tumor growth via shifting macrophages to M1‐like phenotype
Authors: Guo Weiwei , Liu Xiujun , Guo Junting , Gao Ruijuan , Xiang Xiaodong , An Xiqiang , Bai Liping 
Published: June 2022

AbstractMacrophages are the major tumor‐infiltrating leukocytes, and tumor‐associated macrophages (TAM) play a critical role in cancer‐related inflammation since they show alternative polarization to M1 (tumor‐inhibited macrophages) or M2 (tumor‐promoted macrophages) phenotype. Brassica rapa L. (B. rapa) has been clinically proven to have anti‐tumor and immunity‐enhancing activity, and the polysaccharides of B. rapa (BRP) have been reported to have an immunoregulatory effect on macrophages. In this study, we focus on macrophage polarization to investigate the mechanism of anti‐tumor response of BRP in vivo and in vitro. We found that BRP improved the expression of M1 markers, including iNOS, COX‐2, HLA‐DR, CD11b and M1‐related cytokines. The expression of M2 markers Arg‐1, CD206 and CD163 induced by IL‐4 were inhibited by BRP treatment, resulting in the inhibition of tumor growth both in vivo and in co‐culture experiments in vitro. The activation of STAT signaling pathway were significantly regulated by BRP, which are important signals in TAM polarization. Overall, the results indicated that BRP has anti‐tumor effect through mediating macrophage polarization.
Controlling the Properties of Starch from Rice Brokens by Crosslinking with Citric Acid and Sodium Trimetaphosphate
Authors: Kumar Yogesh , Singh Sukhcharn , Saxena D. C. 
Published: June 2022

AbstractStarch from broken rice of an Indian variety (PR114) is crosslinked by citric acid (CA, 12–60%) and sodium trimetaphosphate (STMP, 6–30%) to study structural, morphological, functional, rheological, and thermal properties. The formation of new peak of C═O stretching vibration at 1730 cm–1 by CA and the reduction of ─OH stretching at 3260 cm–1 by STMP starches in the FTIR spectra confirm crosslinking reaction. The XRD pattern reveals reduction in crystallinity of crosslinked starches; however, characteristic peaks disappear with increasing concentration of CA. SEM micrographs show STMP granules are comparable with polygonal shaped and smooth surfaced native granules. However, CA starches show irregular shape, rough surfaces, and growing agglomerates. The effect of crosslinking on pasting properties is detrimental due to reduction in swelling index and solubility. The significant reduction in peak viscosity and flattening of viscosity curve confirms the higher degree of crosslinking (85.60–99.37%). However, crosslinked gels become more flowable, show shear thinning behavior for STMP, and behave differently for CA starches. The dynamic rheology reveals that only native and STMP (6–18%) starches form a solid like paste. In addition, the STMP starches have higher gelatinization temperature, lower enthalpy, and better thermal stability than native starch.
Long‐term post‐crack performance of high‐strength fiber‐reinforced concrete for structural applications
Authors: Bernard Erik Stefan 
Published: June 2022

AbstractThe post‐crack flexural‐tensile performance of fiber‐reinforced concrete (FRC) is a critical property of this material and is often the main justification for inclusion of fibers within a concrete mixture. Given the structural importance of this property, it is critical that performance demonstrated in pre‐qualification trials, and in quality control testing, is sustained throughout the design life of a structure reliant on post‐crack flexural‐tensile resistance. Previous research has indicated that an increase in compressive strength or paste hardness in maturing concrete can promote a change in fiber behavior at cracks from one of pull‐out to rupture. This can lead to a substantial fall in flexural‐tensile strength as the concrete ages. This behavior primarily affects low‐ to medium‐strength steel fibers in high‐strength concrete. It has been reported that use of very high tensile strength steel can preclude this transition, leading to sustained flexural‐tensile performance in late‐age high‐strength concrete. The current investigation has examined the evolution of flexural‐tensile behavior in high‐strength fiber‐reinforced concrete mixtures used in structural applications, to determine whether commercially available fibers made with high‐strength steel wire can resist rupture when the concrete compressive strength exceeds 80 MPa at over 5 years of age.
Correlation-Based Anomaly Detection for the CAN Bus
Authors: Gazdag András , Lupták György , Buttyán Levente 
Published: June 2022

AbstractPrevious attacks have shown that in-vehicle networks have vulnerabilities and a successful attack could lead to significant financial loss and danger to life. In this paper, we propose a Pearson correlation based anomaly detection algorithm to detect CAN message modification attacks. The algorithm does not need a priori information about the communication: it identifies signals based on statistical properties, finds the important correlation coefficients for the correlating signals, and detects attacks as deviations from a previously learned normal state.
Secure Authentication for Everyone! Enabling 2nd-Factor Authentication Under Real-World Constraints
Authors: Fietkau Julian , Zahra Syeda Mehak , Hartung Markus 
Published: June 2022

AbstractMillions of user accounts have been exposed by data breaches within the last years. The leaked credentials pose a huge threat to many because they can be used for credential stuffing and brute-force attacks across all online services. The best solution for this problem seems to be the use of 2nd-factor authentication, like hardware tokens or one-time passwords. While these are great solutions, they cause many problems for users because they are too expensive, difficult to manage, or just not user-friendly. In this paper, we will present the results of a study that shows that users need and want secure authentication, as long as it is quick, easy, and free of charge. Hence, we investigate how recent advancements in smartphone security and authentications standards can be used to build a mobile authenticator that is easy to use, free of charge, and as secure as a hardware token. Therefore we leverage the Trusted Execution Environment of the Android platform to implement a FIDO compliant authentication mechanism on the smartphone. Furthermore, we integrate this mobile authenticator into a password manager app, to reduce user interaction, simplify the setup and provide an encompassing solution for the user.
Update Alpha-1-Antitrypsin-Mangel
Authors: Katzer D. , Briem-Richter A. , Weigert A. , Lainka E. , Dammann S. , Pfister E. D. , Wirth S. , Kardorff R. , Ganschow R. 
Published: June 2022

ZusammenfassungDer Alpha-1-Antitrypsin-Mangel (AATM) ist mit einer Prävalenz bis zu 1:2000 eine der häufigsten monogenetischen Ursachen für eine Lebertransplantation im Kindesalter. Pulmonal manifestiert sich der AATM erst im Erwachsenenalter. Er wird oft zu spät oder überhaupt nicht diagnostiziert. Die initiale Diagnostik ist mit einer Serumspiegelbestimmung einfach und günstig durchführbar. Bei Werten unter 1,1 g/l sollte eine Genotypisierung erfolgen, die im Alpha-1-Antitrypsin-Zentrum Marburg kostenfrei angeboten wird. Aufgrund des sehr heterogenen Verlaufs sollte die weiterführende Betreuung von Patienten mit AATM jedoch Spezialisten mit ausreichender Erfahrung vorbehalten bleiben. Hierfür eignen sich insbesondere die pädiatrischen Alpha-1-Center. Einen hohen Stellenwert haben die Aufklärung sowie die Aufrechterhaltung einer guten Compliance mit regelmäßigen ärztlichen Verlaufskontrollen, um eine Progredienz der Lebererkrankung zu erfassen. Neben Anamnese und körperlicher Untersuchung sind regelmäßige Blutentnahmen und Ultraschalluntersuchungen (inkl. Leberelastographie) notwendig. Therapeutisch stehen neben einer kurativen Lebertransplantation derzeit lediglich supportive Therapien zur Wahl. Sollte eine Lebertransplantation indiziert sein, ist das Langzeit-Outcome erfreulicherweise sehr gut.
Cell-line screening and process development for a fusogenic oncolytic virus in small-scale suspension cultures
Authors: Göbel Sven , Kortum Fabian , Chavez Karim Jaén , Jordan Ingo , Sandig Volker , Reichl Udo , Altomonte Jennifer , Genzel Yvonne 
Published: June 2022

AbstractOncolytic viruses (OVs) represent a novel class of immunotherapeutics under development for the treatment of cancers. OVs that express a cognate or transgenic fusion protein is particularly promising as their enhanced intratumoral spread via syncytia formation can be a potent mechanism for tumor lysis and induction of antitumor immune responses. Rapid and efficient fusion of infected cells results in cell death before high titers are reached. Although this is an attractive safety feature, it also presents unique challenges for large-scale clinical-grade manufacture of OVs. Here we evaluate the use of four different suspension cell lines for the production of a novel fusogenic hybrid of vesicular stomatitis virus and Newcastle disease virus (rVSV-NDV). The candidate cell lines were screened for growth, metabolism, and virus productivity. Permissivity was evaluated based on extracellular infectious virus titers and cell-specific virus yields (CSVYs). For additional process optimizations, virus adaptation and multiplicity of infection (MOI) screenings were performed and confirmed in a 1 L bioreactor. BHK-21 and HEK293SF cells infected at concentrations of 2 × 106cells/mL were identified as promising candidates for rVSV-NDV production, leading to infectious titers of 3.0 × 108TCID50/mL and 7.5 × 107TCID50/mL, and CSVYs of 153 and 9, respectively. Compared to the AGE1.CR.pIX reference produced in adherent cultures, oncolytic potency was not affected by production in suspension cultures and possibly even increased in cultures of HEK293SF and AGE1.CR.pIX. Our study describes promising suspension cell-based processes for efficient large-scale manufacturing of rVSV-NDV.Key points•Cell contact-dependent oncolytic virus (OV) replicates in suspension cells.•Oncolytic potency is not encompassed during suspension cultivation.•Media composition, cell line, and MOI are critical process parameters for OV production.•The designed process is scalable and shows great promise for manufacturing clinical-grade material.
Accuracy of pelvic measurements on virtual radiographic projections based on computed tomography scans compared to conventional radiographs pre- and postoperatively
Authors: Kaiser Dominik , Hoch Armando , Stern Christoph , Sommer Stefan , Sutter Reto , Zingg Patrick O. 
Published: June 2022

Abstract
Background
The anteroposterior (ap) radiograph of the pelvis is decisive in the diagnosis of different pathologies of the hip joint. Technical advantages have reduced the radiation dose of pelvic CT to levels comparable to radiographs. The purpose of this study was to validate if standard radiographic parameters (lateral center edge angle, medial center edge angle, acetabular index, acetabular arc, extrusion index, crossover sign and posterior wall sign) can accurately be determined on radiograph-like projections reconstructed from the CT dataset pre- and postoperatively.

Methods
A consecutive series of patient with symptomatic dysplasia of the hip and a full radiologic workup (radiographs and CT scan pre- and postoperatively) who underwent periacetabular osteotomy were included. Standard radiographic parameters were compared between radiographs and radiograph-like projections by two authors pre- and postoperatively.

Results
A total of 16 hips (32 radiographs/32 radiograph-like projections) were included in the study. No significant difference was found between the radiographs and radiograph-like images for all parameter for both examiners. ICC between radiograph and radiograph-like projections for all investigated parameters showed good to excellent reliability (0.78–0.99) pre- and postoperatively.

Conclusion
Radiograph-like projections show comparable results to radiographs with regard to the important investigated parameters (lateral center edge angle, medial center edge angle, acetabular index, acetabular arc, extrusion index, crossover sign and posterior wall sign). Thus, ultra-low-dose CT scans may reduce the need for conventional radiographs in pre- and postoperative analyses of 3-dimensional hip pathologies in the future, as the advantages increasingly outweigh the disadvantages.
Optimising the management of children with concomitant bladder dysfunction and behavioural disorders
Authors: Eliezer Dilharan D. , Lam Christopher , Smith Angela , Coomarasamy John Mithran , Samnakay Naeem , Starkey Malcolm R. , Deshpande Aniruddh V. 
Published: June 2022

AbstractBladder dysfunction and behavioural disorders in children are commonly concomitant; hence, it is difficult to treat each in isolation. Pharmacotherapy is common treatment for behavioural disorders, and these medications may have intended or unintended positive or negative bladder sequelae. This review identifies the literature regarding the effects of behavioural pharmacotherapy on bladder functioning and possible bladder management strategies in children with concomitant behaviour and bladder disorders to enable clinicians to better manage both conditions. A PROSPERO registered PRISMA-guided review of three major databases was performed. After an initial scoping study revealed significant heterogeneity, a narrative approach was undertaken to discuss the results of all relevant cases relating to children being treated with pharmacotherapy for behaviour disorders and outcomes related to bladder function. Studies were screened to identify those that described effects of commonly prescribed medications in children with behavioural disorders such as stimulants, alpha 2 agonists, tricyclic antidepressants (TCA), serotonin and noradrenergic reuptake inhibitors (SNRI), selective serotonin reuptake inhibitors (SSRI) and antipsychotics, and the findings and implications were summarised. The review identified 46 studies relevant to behavioural pharmacotherapy and bladder function (stimulants (n = 9), alpha 2 agonists (n = 2), TCAs (n = 7), SNRIs (n = 8), SSRIs (n = 8) and antipsychotics (n = 6). Six studies focused specifically on bladder management in children with behavioural disorders with concurrent behavioural pharmacotherapy. This review identifies useful factors that may assist clinicians with predicting unintended bladder effects following initiation of behavioural pharmacotherapy to facilitate the best approach to the treatment of bladder dysfunction in children with behavioural disorders. With this evidence, we have provided a useful decision-making algorithm to aide clinicians in the management of these dual pathologies.
Adaptive data-driven models to best predict the likelihood of live birth as the IVF cycle moves on and for each embryo transfer
Authors: Grzegorczyk-Martin Véronika , Roset Julie , Di Pizio Pierre , Fréour Thomas , Barrière Paul , Pouly Jean Luc , Grynberg Michael , Parneix Isabelle , Avril Catherine , Pacheco Joe , Grzegorczyk Tomasz M. 
Published: June 2022

Abstract

Purpose
To dynamically assess the evolution of live birth predictive factors’ impact throughout the in vitro fertilization (IVF) process, for each fresh and subsequent frozen embryo transfers.

Methods
In this multicentric study, data from 13,574 fresh IVF cycles and 6,770 subsequent frozen embryo transfers were retrospectively analyzed. Fifty-seven descriptive parameters were included and split into four categories: (1) demographic (couple’s baseline characteristics), (2) ovarian stimulation, (3) laboratory data, and (4) embryo transfer (fresh and frozen). All these parameters were used to develop four successive predictive models with the outcome being a live birth event.

Results
Eight parameters were predictive of live birth in the first step after the first consultation, 9 in the second step after the stimulation, 11 in the third step with laboratory data, and 13 in the 4th step at the transfer stage. The predictive performance of the models increased at each step. Certain parameters remained predictive in all 4 models while others were predictive only in the first models and no longer in the subsequent ones when including new parameters. Moreover, some parameters were predictive in fresh transfers but not in frozen transfers.

Conclusion
This work evaluates the chances of live birth for each embryo transfer individually and not the cumulative outcome after multiple IVF attempts. The different predictive models allow to determine which parameters should be taken into account or not at each step of an IVF cycle, and especially at the time of each embryo transfer, fresh or frozen.
Monstrous Content and the Bounds of Discourse
Authors: Ferguson Thomas Macaulay 
Published: June 2022

AbstractBounds consequence provides an interpretation of a multiple-conclusion consequence relation in which the derivability of a sequent "Image missing"is understood as the claim that it is conversationally out-of-bounds to take a position in which each member of Γ is asserted while each member of Δ is denied. Two of the foremost champions of bounds consequence—Greg Restall and David Ripley—have independently indicated that the shape of the bounds in question is determined by conversational practice. In this paper, I suggest that the standard treatments of bounds consequence have focused heavily on the matter of veridicality at the expense of ignoring other features by which conversational bounds are set, prime among them being the matter of content or subject-matter. Furthermore, I argue that the semantic behavior of propositions containing “monstrous” content—content whose introduction is inappropriate to a context independently of veridical considerations—leads to a weak Kleene account of bounds consequence.
Stochastic response determination of U-OWC energy harvesters: a statistical linearization solution treatment accounting for intermittent wave excitation
Authors: Scialò Andrea , Malara Giovanni , Kougioumtzoglou Ioannis A. , Arena Felice 
Published: June 2022

AbstractA novel statistical linearization technique is developed for determining approximately the response statistics and the power output of U-Oscillating Water Column (U-OWC) energy harvesting systems. In this regard, first, the governing equations are derived by employing the unsteady Bernoulli equation. Note that the intermittent, i.e., non-stationary, nature of the wave excitation, occurring in severe sea states due to uncovering of the U-OWC inlet, is explicitly accounted for in the herein proposed model. This is done by multiplying the excitation process with a Heaviside function dependent on the instantaneous free surface displacement. Next, the resulting coupled system of nonlinear integro-differential stochastic equations is solved approximately by relying on a statistical linearization technique. Specifically, the original system of nonlinear equations is replaced by an equivalent linear one, whose parameters and response first- and second-order statistics are obtained by minimizing the mean square error between the two systems. A significant novel aspect of the technique relates to the fact that the Heaviside function is replaced in the equivalent linear system by an “equivalent excitation” coefficient to be determined as part of the statistical linearization solution scheme. Further, compared with other relevant solution schemes adopted in earlier research efforts in the literature, it is shown that the developed technique can be construed as a direct generalization that exhibits an enhanced accuracy degree. The U-OWC installed in the Civitavecchia harbor (Rome, Italy) is considered as an illustrative numerical example, where the reliability of the approximate technique is demonstrated by comparisons with pertinent Monte Carlo simulation data.