bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Pupuk Organik MOF terhadap Pertumbuhan dan Produksi Padi Gogo (Oryza zativa L.) Kultivar Rantepera pada Sistem Tanam yang Berbeda
Authors: Kule Gabriel , Pasolon Yulius B. , Afa La Ode 
Published: April 2022

Penelitian ini bertujuan untuk mengetahui pengaruh pupuk organik MOF terhadap pertumbuhan dan produksi tanaman padi gogo kultivar rantepera pada sistem tanam yang berbeda. Penelitian ini dilaksanakan di Desa Pombulaa Jaya kecamatan Konda Kabupaten Konawe Selatan yang terletak pada kordinat 04000’4.59”S-122031’40.9”E dengan ketinggian tempat ± 13,33 m dpl. dan di Laboratorium Agroteknologi Fakultas Pertanian Universitas Halu Oleo yang dilaksanakan dari bulan Desember 2018 sampai Mei 2019. Penelitian ini menggunakan rancangan petak terbagi dalam pola racangan acak kelompok (RAK). Sistem tanam (T) sebagai petak utama yaitu sistem tanam langsung (T1) dan sistem tanam pindah (T2). Pupuk organik MOF (M) sebagai anak petak yaitu tanpa pupuk MOF (M0), pupuk MOF 5 t.ha-1 (M1) dan pupuk MOF 7 t.ha-1 (M2). Perlakuan ini terdiri dari 6 kombinasi yang diulang sebanyak 3 kali sehingga terdapat 18 unit percobaan. Variabel yang diamati adalah tinggi tanaman (cm), jumlah daun (helai), luas daun (cm-2), umur berbunga, umur panen, panjang malai (cm) per rumpun, total gabah per malai (butir), jumlah gabah isi per malai (butir), jumlah gabah hampa per malai (butir), bobot 1000 butir gabah (g), bobot gabah perumpun (g) dan produksi per hektar (t.ha-1). Data pengamatan dianalisis ragam, jika terdapat pengaruh nyata dan pengaruh sangat nyata dilanjutkan Uji Jarak Berganda Duncan (UJBD) pada taraf kepercayaan 95%. Hasil penelitian menunjukkan bahwa interaksi sistem tanam dan pupuk organik MOF 821 berpengaruh tidak nyata terhadap pertumbuhan dan hasil dua kultivar tanaman padi gogo. Mandiri sistem tanam langsung dapat meningkatkan produksi tanaman dibandingkan dengan sistem tanam pindah dan pupuk MOF dosis 7 t.ha-1 lebih tinggi dibandingkan dengan perlakuan lainnya. Kata kunci: pupuk MOF 831, kultivar rantepera, sistem tanam pindah.
Muna Local Food Defense Post-Arrival of Transmigrants in South Tiworo Subdistrict West Muna Regency
Authors: Mursin Mursin , Suyyuti Nasruddin , Sifatu Wa Ode Sifatu 
Published: April 2022

The purpose of this study was to reveal the pattern of Muna's local food sustainability, and the response of transmigrant communities to Muna's local food. The theory used in this research was Geertz's mindset, Clifford (1973) about ethos, world-view, and the Analysis of sacred symbols with ethnographic methods . Research Results showed that: 1) The pattern of local food security of the Muna community through: at least every planting season there are three types of plants: rice, corn, sweet potatoes, cassava, and vegetables. Every day, there are at least five types of food: rice, processed corn, processed cassava, vegetables, and side dishes, as well as completing the life cycle ceremony. Local food of the Muna community can disappear if it eliminates the life cycle ceremony because of the influence of the new Islamic religion. In the development of leaves as the staple of vegetables, they have health functions. Muna's local food that still survives today is cahitela, paewuna, mafusau, midawa, ghofa, mafu, tonea, rapo-rapo, bhanggai, romedawa, popasa, ghontoghe, usa, ghoenu, lembeghu, wuragha, robu, foo, paranggi, sirikaea, bubuno, katapi, kahawa, pumpkin, ghotimu, conduru, pariah, tereka, kula, lawue, kentanooemorindi, kenta we tehi ,, kaliwuoemorindi, kaliwu we tehi. 2) Transmigrants also participate in consuming local Muna food. Conclusion: The work ethic and farming patterns that are still maintained up to the new Islamic religious school faced by the Muna community in maintaining local food. As a result, a relative of the Muna community could have a conflict just because of the implementation of a life cycle ceremony. The government should be able to revive the use of local food in a scientific way. Keywords: Defense, Local Food, Transmigrants
Relationship between Nutritional Status, Anthropometric Measurements and Dietary Inflammatory Index in Professional Football Players
Authors: KENGER Emre Batuhan , EREN Fatih , GÜNEŞ Fatma Esra 
Published: April 2022

Objective: This study was carried out to evaluate the relationship between the nutritional status, anthropometric measurements and dietary inflammatory index (DII) of professional football players exposed to long-term intense exercise.
Method: Twenty-one professional male football players with a mean age of 26.00±5.69 years playing in the same club participated in the study. The nutritional status of the football players was evaluated with 3-day food consumption record (2 days of training and 1 match day). DII scores were calculated using data on 34 nutrient/nutritional ingredients obtained from the food consumption records. Body fat percentage in the anthropometric evaluations were determined by caliper and skinfold thicknesses.
Results: The median DII scores of the football players were found as – 3.42 (-9.95 – 0.95), and their nutritional intake were found to be antiinflammatory. When the relationship between the DII scores of the football players and their anthropometric measurements was examined, a positive and significant correlation (R: .476; p: .029) was found between their DII score and their abdominal adiposity. However, there was no significant correlation (p> .05) between the DII scores and the other anthropometric measurements. In addition, there was a significant negative correlation (R: – .468; p: .032) between fiber consumption and abdominal adiposity, and a significant positive correlation between carbohydrate and fat consumption and body weight (respectively R= .730 p= .000; R= .526 p= .014).
Conclusion: It has been revealed that the football players participating in our study generally have an anti-inflammatory diet. It was also found that abdominal adiposity was higher in the football players with high DII scores.
Effects of Foot-Core Training on Foot-Ankle Kinematics and Running Kinetics in Runners: Secondary Outcomes From a Randomized Controlled Trial
Authors: Matias Alessandra B. , Watari Ricky , Taddei Ulisses T. , Caravaggi Paolo , Inoue Rafael S. , Thibes Raissa B. , Suda Eneida Y. , Vieira Marcus F. , Sacco Isabel C. N. 
Published: April 2022

This study investigated the effectiveness of an 8-week foot-core exercise training program on foot-ankle kinematics during running and also on running kinetics (impact loads), with particular interest in biomechanical outcomes considered risk factors for running-related injuries in recreational runners. A single-blind, randomized, controlled trial was conducted with 87 recreational runners randomly allocated to either the control (CG) or intervention (IG) group and assessed at baseline and after 8 weeks. The IG underwent foot-core training 3 times/week, while the CG followed a placebo lower-limb stretching protocol. The participants ran on a force-instrumented treadmill at a self-selected speed while foot-segment motion was captured simultaneously with kinetic measurements. After the intervention, there were statistically significant changed in foot biomechanics, such as: IG participants strike the ground with a more inverted calcaneus and a less dorsiflexed midfoot than those in the CG; at midstance, ran with a less plantarflexed and more adducted forefoot and a more abducted hallux; and at push-off, ran with a less dorsiflexed midfoot and a less adducted and more dorsiflexed hallux. The IG runners also had significantly decreased medial longitudinal arch excursion (p = 0.024) and increased rearfoot inversion (p = 0.037). The 8-week foot-core exercise program had no effect on impact (p = 0.129) and breaking forces (p = 0.934) or on vertical loading rate (p = 0.537), but it was positively effective in changing foot-ankle kinematic patterns.”
Signaling Pathway and Small-Molecule Drug Discovery of FGFR: A Comprehensive Review
Authors: Zheng Jia , Zhang Wei , Li Linfeng , He Yi , Wei Yue , Dang Yongjun , Nie Shenyou , Guo Zufeng 
Published: April 2022

Targeted therapy is a groundbreaking innovation for cancer treatment. Among the receptor tyrosine kinases, the fibroblast growth factor receptors (FGFRs) garnered substantial attention as promising therapeutic targets due to their fundamental biological functions and frequently observed abnormality in tumors. In the past 2 decades, several generations of FGFR kinase inhibitors have been developed. This review starts by introducing the biological basis of FGF/FGFR signaling. It then gives a detailed description of different types of small-molecule FGFR inhibitors according to modes of action, followed by a systematic overview of small-molecule-based therapies of different modalities. It ends with our perspectives for the development of novel FGFR inhibitors.
Varicose Veins and Risk of Venous Thromboembolic Diseases: A Two-Sample-Based Mendelian Randomization Study
Authors: Li Ruihao , Chen Zuoguan , Gui Liang , Wu Zhiyuan , Miao Yuqing , Gao Qing , Diao Yongpeng , Li Yongjun 
Published: April 2022

Background:Varicose veins are found to be associated with increased risk of venous thromboembolism (VTE) in many observational studies, but whether varicose veins are causally associated with VTE remains unclear. Therefore, we used a series of Mendelian randomization (MR) methods to investigate that association.Methods23 independent single-nucleotide polymorphisms (SNPs) for varicose veins were obtained from the Pan UK Biobank analysis. The outcomes datasets for deep vein thrombosis (DVT), pulmonary embolism (PE) and venous thromboembolism (VTE) were obtained from the FinnGen study. Before analysis, body mass index (BMI) and height were included as confounders in our MR model. Basic MR [inverse-variance weighted (IVW), weight-median, penalized weighted-median and MR-Egger methods] and MR-PRESSO were performed against each outcome using the whole SNPs and SNPs after excluding those associated with confounders. If causal associations were suggested for any outcome, a basic MR validation analysis, a multivariable MR analysis with BMI and height, a Causal Analysis Using Summary Effect estimates (CAUSE), and a two-step MR analysis with BMI and height, would follow.ResultsUsing 21 qualified SNPs, the IVW method (OR: 1.173, 95% CI: 1.070–1.286, p &lt; 0.001, FDR = 0.002), the weighted median method (OR: 1.255, 95% CI: 1.106–1.423, p &lt; 0.001, FDR = 0.001), the penalized weighted median method (OR: 1.299, 95% CI: 1.128–1.495, p &lt; 0.001, FDR = 0.001) and the MR-PRESSO (OR: 1.165, 95% CI: 1.067–1.273, p = 0.003, FDR = 0.009) suggested potential causal effect of varicose veins on DVT, but no cause effect was found for PE and VTE. Excluding SNPs associated with confounders yielded similar results. The causal association with DVT was validated using a self-reported DVT cohort (IVW, OR: 1.107, 95% CI: 1.041–1.178, p = 0.001). The causal association maintained after adjustment for height (OR = 1.105, 95% CI: 1.028–1.188, p = 0.007), BMI (OR = 1.148, 95% CI: 1.059–1.244, p &lt; 0.001) and them both (OR = 1.104, 95% CI: 1.035–1.177, p = 0.003). The causal association also survived the strict CAUSE (p = 0.018). Finally, in two-step MR, height and BMI were found to have causal effects on both varicose veins and DVT.ConclusionGenetically predicted varicose veins may have a causal effect on DVT and may be one of the mediators of obesity and taller height that predispose to DVT.
Risk Stratification by Coronary Perfusion Pressure in Left Ventricular Systolic Dysfunction Patients Undergoing Revascularization: A Propensity Score Matching Analysis
Authors: Hsieh Ming-Jer , Chen Chun-Chi , Chen Dong-Yi , Lee Cheng-Hung , Ho Ming-Yun , Yeh Jih-Kai , Huang Yu-Chang , Lu Yu-Ying , Chang Chieh-Yu , Wang Chao-Yung , Chang Shang-Hung , Hsieh I-Chang 
Published: April 2022

BackgroundCoronary perfusion pressure (CPP) and coronary artery stenosis are responsible for myocardial perfusion. However, how CPP-related survival outcome affects revascularization is unclear.ObjectiveThe aim of this study is to investigate the prognostic role of CPP in patients with left ventricular systolic dysfunction (LVSD) undergoing percutaneous coronary intervention (PCI) with complete revascularization (CR) or reasonable incomplete revascularization (RIR).MethodsWe retrospectively screened 6,076 consecutive patients in a registry. The residual synergy between percutaneous coronary intervention with Taxus and cardiac surgery (SYNTAX) score (rSS) was used to define CR (rSS = 0) and RIR (0&lt;rSS≤8). Propensity score matching was performed to reduce bias between RIR and CR. The primary endpoint was all-cause mortality.ResultsIn total, 816 patients with LVSD who underwent CR or RIR were enrolled. After a mean follow-up of 4.6 years, 134 patients died. Both CPP and RIR independently predicted mortality in the total population. After 1:1 matching, 175 pairs of RIR and CR were found in patients with CPP &gt; 42 mmHg. Moreover, 101 pairs of RIR and CR were present in patients with CPP ≤ 42 mmHg. In patients with CPP &gt; 42 mmHg, RIR was not significantly different from CR in long-term mortality [hazard ratio (HR) 1.20; 95% confidence interval (CI):0.70–2.07; p = 0.513]; However, in patients with CPP≤42 mmHg, RIR had a significantly higher mortality risk than CR (HR 2.39; 95% CI: 1.27–4.50; p = 0.007).ConclusionsThe CPP had a risk stratification role in selecting different revascularization strategies in patients with LVSD. When patients with LVSD had CPP &gt; 42 mmHg, RIR was equivalent to CR in survival. However, when patients with LVSD had CPP ≤ 42 mmHg, RIR had a significantly higher mortality risk than CR.
Assessing the Contribution of Glacier Melt to Discharge in the Tropics: The Case of Study of the Antisana Glacier 12 in Ecuador
Authors: Gualco Luis Felipe , Maisincho Luis , Villacís Marcos , Campozano Lenin , Favier Vincent , Ruiz-Hernández Jean-Carlos , Condom Thomas 
Published: April 2022

Tropical glaciers are excellent indicators of climate variability due to their fast response to temperature and precipitation variations. At same time, they supply freshwater to downstream populations. In this study, a hydro-glaciological model was adapted to analyze the influence of meteorological forcing on melting and discharge variations at Glacier 12 of Antisana volcano (4,735–5,720 m above sea level (a.s.l.), 1.68 km2, 0°29′S; 78°9′W). Energy fluxes and melting were calculated using a distributed surface energy balance model using 20 altitude bands from glacier snout to the summit at 30-min resolution for 684 days between 2011 and 2013. The discharge was computed using linear reservoirs for snow, firn, ice, and moraine zones. Meteorological variables were recorded at 4,750 m.a.s.l. in the ablation area and distributed through the altitudinal range using geometrical corrections, and measured lapse rate. The annual specific mass balance (−0.61 m of water equivalent -m w.e. y−1-) and the ablation gradient (22.76 kg m−2 m−1) agree with the values estimated from direct measurements. Sequential validations allowed the simulated discharge to reproduce hourly and daily discharge variability at the outlet of the catchment. The latter confirmed discharge simulated (0.187 m3 s−1) overestimates the streamflow measured. Hence it did not reflect the net meltwater production due to possible losses through the complex geology of the site. The lack of seasonality in cloud cover and incident short-wave radiation force the reflected short-wave radiation via albedo to drive melting energy from January to June and October to December. Whereas the wind speed was the most influencing variable during the July-September season. Results provide new insights on the behaviour of glaciers in the inner tropics since cloudiness and precipitation occur throughout the year yielding a constant short-wave attenuation and continuous variation of snow layer thickness.
Hybrid Close-Loop Systems Versus Predictive Low-Glucose Suspend and Sensor-Augmented Pump Therapy in Patients With Type 1 Diabetes: A Single-Center Cohort Study
Authors: Lunati Maria Elena , Morpurgo Paola Silvia , Rossi Antonio , Gandolfi Alessandra , Cogliati Irene , Bolla Andrea Mario , Plebani Laura , Vallone Luciana , Montefusco Laura , Pastore Ida , Cimino Vincenzo , Argenti Sabrina , Volpi Graziella , Zuccotti Gian Vincenzo , Fiorina Paolo 
Published: April 2022

IntroductionPredictive low-glucose suspend (PLGS) and hybrid closed-loop (HCL) systems may improve glucose control and quality of life in type 1 diabetic individuals. This is a cross-sectional, single-center study to compare the effect on metabolic control and glucose variability of PLGS and HCL systems as compared to standard sensor-augmented pump (SAP) therapy.MethodsWe retrospectively analyzed 136 adults (men/women 69/67, mean age 47.3 ± 13.9 years) with T1D on insulin pump therapy, divided accordingly to type of insulin pump system (group 1: SAP, 24 subjects; group 2: PLGS, 49 subjects; group 3: HCL, 63 subjects). The groups were matched for age, gender, years of disease, years of CSII use, and CGM wear time.ResultsThe analysis of CGM metrics, in the three groups, showed a statistically significant different percentage of time within the target range, defined as 70–180 mg/dl, with a higher percentage in group 3 and significantly less time spent in the hypoglycemic range in groups 2 and 3. The three groups were statistically different also for the glucose management indicator and coefficient of variation percentage, which were progressively lower moving from group 1 to group 3. In the HCL group, 52.4% of subjects reached a percentage of time passed in the euglycemic range above 70%, as compared to 32.7% in those with PLGS and 20.2% in those with SAP. A positive correlation between the higher percentage of TIR and the use of auto-mode was evident in the HCL group. Finally, the three groups did not show any statistical differences regarding the quality-of-life questionnaire, but there was a significant negative correlation between CV and perceived CSII-use convenience (r = -0.207, p = 0.043).ConclusionHCL systems were more effective in improving glucose control and in reducing the risk of hypoglycemia in patients with type 1 diabetes, thereby mitigating risk for acute and chronic complications and positively affecting diabetes technologies’ acceptance.
Hyperglycemia and Physical Impairment in Frail Hypertensive Older Adults
Authors: Pansini Antonella , Lombardi Angela , Morgante Maria , Frullone Salvatore , Marro Anna , Rizzo Mario , Martinelli Giuseppe , Boccalone Eugenio , De Luca Antonio , Santulli Gaetano , Mone Pasquale 
Published: April 2022

BackgroundFrailty is a multidimensional condition typical of elders. Frail older adults have a high risk of functional decline, hospitalization, and mortality. Hypertension is one of the most common comorbidities in elders. Hyperglycemia (HG) is frequently observed in frail older adults, and represents an independent predictor of worst outcomes, with or without diabetes mellitus (DM). We aimed at investigating the impact of HG on physical impairment in frailty.MethodsWe studied consecutive older adults with frailty and hypertension at the ASL (local health unit of the Italian Ministry of Health) of Avellino, Italy, from March 2021 to September 2021. Exclusion criteria were: age &lt;65 years, no frailty, no hypertension, left ventricular ejection fraction &lt;25%, previous myocardial infarction, previous primary percutaneous coronary intervention and/or coronary artery bypass grafting. Blood glucose, Hb1Ac, and creatinine were measured in all patients. Physical frailty was assessed applying the Fried Criteria; we performed a 5-meter gait speed (5mGS) test in all patients.Results149 frail hypertensive older adults were enrolled in the study, of which 82 had normoglycemia (NG), and 67 had HG. We observed a significantly slower 5mGS in the HG group compared to the NG group (0.52 ± 0.1 vs. 0.69 ± 0.06; p&lt;0.001). Moreover, we found a strong and significant correlation between 5mGS and glycemia (r: 0.833; p&lt;0.001). A multivariable linear regression analysis using 5mGS as a dependent variable revealed a significant independent association with glycemia (p&lt;0.001) after adjusting for likely confounders.ConclusionsHG drives physical impairment in frail hypertensive older adults independently of DM.
Cardiovascular Autonomic Neuropathy in Type 1 Diabetes Is Associated With Disturbances in TCA, Lipid, and Glucose Metabolism
Authors: Hansen Christian S. , Suvitaival Tommi , Theilade Simone , Mattila Ismo , Lajer Maria , Trošt Kajetan , Ahonen Linda , Hansen Tine W. , Legido-Quigley Cristina , Rossing Peter , Ahluwalia Tarunveer S. 
Published: April 2022

IntroductionDiabetic cardiovascular autonomic neuropathy (CAN) is associated with increased mortality and morbidity. To explore metabolic mechanisms associated with CAN we investigated associations between serum metabolites and CAN in persons with type 1 diabetes (T1D).Materials and MethodsCardiovascular reflex tests (CARTs) (heart rate response to: deep breathing; lying-to-standing test; and the Valsalva maneuver) were used to diagnose CAN in 302 persons with T1D. More than one pathological CARTs defined the CAN diagnosis. Serum metabolomics and lipidomic profiles were analyzed with two complementary non-targeted mass-spectrometry methods. Cross-sectional associations between metabolites and CAN were assessed by linear regression models adjusted for relevant confounders.ResultsParticipants were median (IQR) aged 55(49, 63) years, 48% males with diabetes duration 39(32, 47) years, HbA1c 63(55,69) mmol/mol and 34% had CAN. A total of 75 metabolites and 106 lipids were analyzed. In crude models, the CAN diagnosis was associated with higher levels of hydroxy fatty acids (2,4- and 3,4-dihydroxybutanoic acids, 4−deoxytetronic acid), creatinine, sugar derivates (ribitol, ribonic acid, myo-inositol), citric acid, glycerol, phenols, phosphatidylcholines and lower levels of free fatty acids and the amino acid methionine (p&lt;0.05). Upon adjustment, positive associations with the CAN diagnoses were retained for hydroxy fatty acids, tricarboxylic acid (TCA) cycle-based sugar derivates, citric acid, and phenols (P&lt;0.05).ConclusionMetabolic pathways, including the TCA cycle, hydroxy fatty acids, phosphatidylcholines and sugar derivatives are associated with the CAN diagnosis in T1D. These pathway may be part of the pathogeneses leading to CAN and may be modifiable risk factors for the complication.
Optimal Planning of Integrated Energy System Considering Convertibility Index
Authors: Wang Ying , Zhao Jing , Zheng Tao , Fan Kai , Zhang Kaifeng 
Published: April 2022

Nowadays, developing an integrated energy system (IES) is considered as an effective pattern to improve energy efficiency and reduce energy supply costs. This study proposes a new index—convertibility index (CI)—to quantitatively assess the flexibility of the IES regarding the energy conversion processes between different energy flow types. Based on the CI constraint, a planning problem is modeled as a bi-level optimization problem. To solve the proposed bi-level problem, a hybrid genetic algorithm (GA)—MILP algorithm—is developed. A case study is carried out to verify the effectiveness of the proposed method. The results show that the total cost of the IES will increase with the CI constraint. For a given case study, the total cost increases by 26.2% when the CI decreases to 0.7 and increases by 3.7% when the CI increases to 1.6. Sensitivity analysis shows that the total numbers and capacities of conversion devices show an overall increasing trend with the increase in the CIs. Meanwhile, the total cost decreases quickly at first and then slightly increases, which, in a whole, shows a “Nike” shape. With different CI constraints, the IES MW per CI ranges from 31.8 to 37.5 MW, and the average cost increase is 2.229 million yuan (2.1%/0.1 CI).