bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship among summer atmospheric boundary layer height over the Taklimakan Desert, its land surface parameters and Eurasian circulation
Authors: Wang Minzhong , Zhang Jiantao 
Published: July 2022

AbstractTo investigate the relationship among summer atmospheric boundary layer (ABL) over the Taklimakan Desert (TD), its land surface parameters and large scale meteorological field, the Urumqi Institute of Desert Meteorology of China Meteorological Administration conducted a comprehensive observation of boundary layer in Tazhong, the hinterland of TD from July 1 to 31, 2016. The correlations between the ABL height and surface sensible heat, latent heat, air temperature, turbulent kinetic energy (TKE) and buoyancy term are analyzed by using the observed GPS sounding data, the surface layer micro meteorological data in the hinterland of the TD and ERA5 reanalysis data so as to study the correlation of the ABL height and Eurasian circulation field. The research results indicate: (1) The height of summer ABL over the TD does not fully correspond with the variation tendency of surface sensible heat flux. In addition to surface sensible heat, large scale advection and residual mixed layer (RML) are also crucial factor influencing ABL. (2) The surface TKE over the TD is consistent with ABL height variation, with the correlation coefficient of 0.62. Hence the equation of ABL height and TKE is expressed as: Y = 1609.2X4 – 12,828X3 + 35,617X2 –39,514X + 15,858. (3) When the ABL height over the TD is quite high, 500 hPa altitude in Xinjiang is mostly controlled by anticyclone circulation, and the easterly low level jet (LLJ) tends to be formed at 850 hPa the next night. (4) The high correlation areas of summer ABL height over the TD and Eurasian temperature field are Xinjiang and Balkash Lake region. Significant positive correlation is identified between the ABL height and the temperature field at 850, 700, and 500 hPa of the above regions. The maximum correlation coefficient reaches 0.7. The study deepens the understanding of the relationship among the ABL process over the TD, land surface parameters and Eurasian circulation.
Arabidopsis plants engineered for high root sugar secretion enhance the diversity of soil microorganisms
Authors: Song Min , Zhang Xingjian , Yang Jintao , Gao Chen , Wei Yahong , Chen Shaolin , Liesche Johannes 
Published: July 2022

AbstractPlants secrete sugars from their roots into the soil, presumably to support beneficial plant‐microbe interactions. Accordingly, manipulation of sugar secretion might be a viable strategy to enhance plant health and productivity. To evaluate the effect of increased root sugar secretion on plant performance and the soil microbiome, we overexpressed glucose and sucrose‐specific membrane transporters in root epidermal cells of the model plant Arabidopsis thaliana. These plants showed strongly increased rates of sugar secretion in a hydroponic culture system. When grown on soil, the transporter‐overexpressor plants displayed a higher photosynthesis rate, but reduced shoot growth compared to the wild‐type control. Amplicon sequencing and qPCR analysis of rhizosphere soil samples indicated a limited effect on the total abundance of bacteria and fungi, but a strong effect on community structure in soil samples associated with the overexpressors. Notable changes included the increased abundance of bacteria belonging to the genus Rhodanobacter and the fungi belonging to the genus Cutaneotrichosporon, while Candida species abundance was reduced. The potential influences of the altered soil microbiome on plant health and productivity are discussed. The results indicate that the engineering of sugar secretion can be a viable pathway to enhancing the carbon sequestration rate and optimizing the soil microbiome.
Interaction study of salvianolic acids for injection on pharmacokinetics of clopidogrel in rats using LC–MS/MS
Authors: Zheng Dayong , Li Xiao , Chu Yang , Li Yazhuo , Li Dekun , Ju Aichun , Wu Yi , Xie Yuesheng , Li Wei 
Published: July 2022

AbstractSalvianolic acids for injection (SAI) is developed from traditional Chinese medicine and approved for the treatment of cardiovascular and cerebrovascular diseases. Clopidogrel is an inhibitor of platelet aggregation, which is often prescribed for patients in combination with SAI. This present study aimed to assess the effects of SAI on the pharmacogenomics, pharmacokinetics, and pharmacodynamics of clopidogrel, thereby ensuring the safety and efficacy of coadministration. In vitro cytochrome P450 isoenzyme assays were performed in human liver microsomes using LC–MS/MS method to assess the metabolites of CYPs substrates. The effects of SAI on the pharmacokinetic and pharmacodynamic behaviors of clopidogrel were investigated in rats. The main pharmacokinetic parameters were analyzed using LC–MS/MS. Prothrombin time, activated partial thromboplastin time, bleeding time, and inhibition of platelet aggregation were measured to evaluate the effects of pharmacodynamics. Our study revealed that the clinical dose of SAI has no significant inhibitory effect on clopidogrel‐related liver microsome metabolic CYP450 isoenzymes. Moreover, SAI did not affect the pharmacokinetics of clopidogrel when rats were administered both single and multiple doses. In pharmacodynamic study, SAI has no effect on platelet aggregation rate, prothrombin time, and activated partial thromboplastin time of clopidogrel but could significantly prevent the risk of bleeding caused by clopidogrel.
Metastatic melanoma of the heart: Retrospective cohort study and systematic review of prevalence, clinical characteristics, and outcomes
Authors: Balinski Alexander M. , Vasbinder Alexi L. , Kerndt Connor C. , Catalan Tonimarie C. , Parry Nathan P. , Rehman Rafey A. , Blakely Pennelope , Yeow Raymond Y. , Leja Monika J. , Lao Christopher D. , Fecher Leslie A. , Hayek Salim S. 
Published: July 2022

AbstractBackgroundCardiac metastasis of melanoma is rare and typically diagnosed post‐mortem. Here we perform a retrospective cohort study and systematic review of patients with metastatic melanoma to characterize prevalence, clinical characteristics, and outcomes of cardiac metastasis.MethodsWe reviewed the electronic medical records of all outpatients with metastatic melanoma who underwent evaluation at the University of Michigan in Ann Arbor from January 2009 to January 2022, identifying patients with a clinical or histopathologic diagnosis of cardiac metastasis. We performed a systematic review of the literature to summarize the clinical characteristics and outcomes of patients with melanoma and cardiac metastasis.ResultsOverall, 23 of 1254 (1.8%) patients with metastatic melanoma were diagnosed with cardiac metastasis. Cardiac metastasis was reported in the right ventricle (65%), left ventricle (35%), and right atrium (35%). A total of 11 (48%) patients experienced at least one cardiovascular complication after the diagnosis of cardiac metastasis, the most common being arrhythmia (30%), heart failure (22%), and pericardial effusion (17%). Immunotherapy was more commonly used in patients with cardiac metastasis (80% vs 65%; p = 0.005). Mortality at 2‐years post‐diagnosis was higher for patients with cardiac metastasis compared to those without (59% vs 37%; p = 0.034). Progression of malignancy was the underlying cause of death of all patients.ConclusionsCardiac metastasis occurs in <2% of patients with metastatic melanoma, can affect all cardiac structures, and is associated with various cardiovascular complications and high mortality.
Comparative evaluation of the functionality of faba bean protein isolates with major legume proteins in the market
Authors: Shi Dai , Nickerson Michael T. 
Published: July 2022

AbstractBackground and ObjectivesThe production of faba beans (Vicia Faba L.) is emerging in the Canadian prairies. To investigate their utilization potential as value‐added ingredients, the physicochemical and functional properties of protein isolates prepared from three faba bean cultivars (Fabelle, Malik, and Snowbird) currently grown in Canada were compared with those of yellow pea (CDC Amarillo) and soybean (AAC 26‐15).FindingsHigher than pea (23.1%), the faba bean had protein contents of ~31.4% and a small amount of fat (~1.2%). The protein isolates of faba bean (FPI), pea (PPI), and soy (SPI) were broadly comparable in surface tension, protein solubility, and oil holding capacity; however, surface charge was higher for FPI. The interfacial tension, water holding capacity, foaming, and emulsifying properties were also generally similar between FPI and PPI but different from SPI. Among faba bean cultivars, Snowbird was richer in protein with a higher proportion of legumins and was better at stabilizing emulsions while having a lower emulsifying activity.ConclusionsThe functionalities of FPI broadly resembled those of PPI, while being comparable or higher to those of SPI, suggesting the potential of using FPI as an alternative functional ingredient in product formulations.Significance and NoveltyThe study on the representative cultivars of Canadian‐grown faba beans updated the knowledge base concerning the functional differences among cultivars and how they compete with major legume proteins in the market, while providing insights on possible applications of faba bean protein ingredients.
Polymethylhydrosiloxane (PMHS) as Sustainable Reductant in the Titanocene Catalyzed Epoxide Hydrosilylation
Authors: Schacht Jonathan Heinrich , Wu Shangze , Klare Sven , Höthker Sebastian , Schmickler Niklas , Gansäuer Andreas 
Published: July 2022

AbstractHere, we describe that polymethylhydrosiloxane (PMHS) is a sustainable terminal reductant in the titanocene catalyzed hydrosilylation of epoxides. The products formally constitute the anti‐Markovnikov products of H2O‐addition to alkenes. PMHS is not only a more sustainable and cheaper reductant than other silanes such as PhSiH3 and Ph(Me)SiH2. It also results in a higher diastereoselectivity of epoxide reduction.
Reactivity of Primary Phosphines and Primary Phosphine Sulfides towards Imines
Authors: Lamberink Jan‐Willem , Boyle Paul D. , Gilroy Joe B. , Noël James J. , Blacquiere Johanna M. , Ragogna Paul J. 
Published: July 2022

AbstractReactivity of primary phosphines with two stoichiometric equivalents of imine results in the formation of bis‐α‐aminophosphines (2 a–e), which can be subsequently oxidized in the presence of S8 or H2O2 to generate air stable bis‐α‐aminophosphine sulfides (2 b–m(S/O)). To elucidate the mechanism of this three‐component reaction, Hammett analysis, kinetic isotope effect (KIE), and trapping experiments were performed. Ultimately a P(V)–P(III) tautomerization is invoked, followed by nucleophilic attack by the P(III) species to generate the desired products.
Cold heavy oil production with sand simulation including wormhole propagation and foamy oil behaviour
Authors: Sahari Moghaddam Farzan , El‐Naghy Mohammed , Aborig Amer , Etminan Amin 
Published: July 2022

AbstractCold heavy oil production with sand (CHOPS) is a primary production method used for heavy oil reservoirs with no requirements of external energy consumption. A new model for CHOPS is simulated by incorporating wormhole propagation and foamy oil behaviour mechanisms to evaluate the recovery of an extra‐heavy oil reservoir of the Athabasca region. The most critical mechanisms of CHOPS, wormhole propagation and foamy oil behaviour, are captured by using Wang's model for wormhole propagation and Uddin's model of gas exsolution. After 120 months of simulation, 53.38%, 99.76%, and 100% of wormhole propagation were achieved during three time steps of 12, 48, and 60 months, respectively, toward the sides of the studied reservoir section. The propagation was achieved within all directions of the investigated section compatible with the erratic nature of wormhole propagation. Furthermore, the application of Uddin's model was incorporated into production by reducing the fluid viscosity as a result of the foamy oil behaviour. Over 3% of the recovery was achieved at the end of the primary CHOPS phase simulation by taking into account that we modelled the recovery based on highly viscous oil with API 7.5. Finally, the model can provide an improved understanding of the primary CHOPS process by considering its two significant mechanisms.
Supramolecular Radical Switches Regulated by Host‐Guest Chemistry
Authors: Ye Yu‐Yuan , Wang Zi‐Xin , Xu Shi‐Yuan , Lin Xiao‐Wei , Luo Jie , Li Wen‐Zhen , Wang Xiao‐Qiang 
Published: July 2022

Comprehensive SummaryWater‐soluble thermal initiators are important radical sources to be applied in various fields. However, the uncontrolled radical generation from the high sensitivity of initiators may cause disadvantages in the applications. Here, we present a series of supramolecular radical switches regulated by the host‐guest chemistry between initiators and cucurbit[8]uril (CB [8]). Thermal initiators (VA‐044, VA‐056, VA‐057) can be spontaneously encapsulated into the cavity of CB [8] to “turn off” their radical‐generation ability. Their activity will instantaneously “turn on” in the presence of other competitors such as 1‐adamantylamine (ADA). Further, we demonstrated the free radical polymerization of N‐isopropylacrylamide using initiators, inhibiting its activity by binding with CB [8] and initiating reaction by adding ADA. These novel supramolecular radical switches provide a facile strategy to control the generation of free radicals in a “plug‐and‐play” manner, which may arouse research interests in polymerization, catalysis, and the biomedical field.
Candida species detection in patients with chronic periodontitis: A systematic review and meta‐analysis
Authors: Slazhneva Ekaterina , Tikhomirova Ekaterina , Tsarev Victor , Orekhova Liudmila , Loboda Ekaterina , Atrushkevich Victoria 
Published: July 2022

AbstractObjectivesTo assess the Candida species occurrence rate and concentration in periodontal pockets in chronic periodontitis (CP) by meta‐analysis.Materials and MethodsA search was performed of articles published between January 1, 2010, and October 1, 2020, in English and in Russian, in the electronic databases MEDLINE‐PubMed, Google Scholar, The Cochrane Library, ClinicalTrials.gov, Research Gate, eLIBRARY, and Cyberleninka (PROSPEROCRD42021234831). The odds ratio (OR), standardized mean difference (SMD), and 95% confidence interval (CI) were calculated using Review Manager 5.4.1 to compare the risk of CP when Candida spp. were detected in the gingival sulcus or periodontal pocket and to compare Candida spp. density counts in patients with CP and periodontally healthy patients.ResultsTwenty‐six studies were included in the systematic review and 11 were included in the meta‐analysis. The results showed that Candida spp. may increase the chance of CP development by 1.76 times (OR = 1.76; 95% CI = 1.04–2.99; Z = 2.10; p = .04; I2 = 61%). More Candida spp. were found in patients with CP than in periodontally healthy patients (SMD = 1.58; 95% CI = 0.15−3.02; p = .03; I2 = 98%). No data were found relating to the statistically significant influence of Candida glabrata, Candida krusei and Candida tropicalis on CP development.ConclusionWe found that Candida albicans insignificantly increased the risk of CP development but, due to the heterogeneity of the included studies, further research is necessary to determine the exact role of Candida spp. in the development and course of the inflammatory periodontal diseases.
Hybrid closure of ventricular septal defect and implantation of systemic right ventricular assist device
Authors: Soquet Jerome , Houeijeh Ali , Richardson Marjorie , Hebbar Eleonore , Vaksmann Guy , Baudelet Jean‐Benoit , Moussa Mouhamed Djahoum , Vincentelli Andre 
Published: July 2022

AbstractA 50‐year‐old female patient was readmitted with refractory systemic right ventricular failure. The patient underwent a Mustard procedure during childhood for transposition of the great arteries. A significant residual ventricular septal defect was present, which represents a major risk factor of death following ventricular assist device. We describe the combination of ventricular assist device implantation preceded by hybrid closure of ventricular septal defect.
Long‐term events following catheter‐ablation for atrial fibrillation in heart failure with preserved ejection fraction
Authors: Ishiguchi Hironori , Yoshiga Yasuhiro , Shimizu Akihiko , Ueyama Takeshi , Fukuda Masakazu , Kato Takayoshi , Fujii Shohei , Hisaoka Masahiro , Uchida Tomoyuki , Omuro Takuya , Okamura Takayuki , Kobayashi Shigeki , Yano Masafumi 
Published: July 2022

AbstractAimsData regarding prognostic events following catheter ablation (CA) for atrial fibrillation (AF) in patients with heart failure with preserved ejection fraction (HFpEF) are scarce. We conducted this study to compare the incidence of major adverse clinical events (MACE) following CA for AF between patients with HFpEF and those with systolic heart failure (HF).Methods and resultsThis single‐centre observational study included 142 patients with HF who underwent CA for AF (median follow‐up: 4.0 [2.6, 6.3] years). The patients were grouped based on the presence of HFpEF (n = 84) and systolic HF (left ventricular ejection fraction <50%, n = 58). We compared the cumulative incidence and incidence rate of MACE, comprising all‐cause death, unplanned cardiovascular hospitalization (CVH), and HF hospitalization (HFH) between both groups and the number of HFH before and after CA in each group. Multivariate analysis was performed to identify the predictors of MACE in patients with HFpEF. The incidence of MACE was comparable between the groups (following the first procedure: HFpEF: 23%, 4.7/100 person‐years, vs. systolic HF: 28%, 6.6/100 person‐years, P = 0.18; last procedure: 20%, 4.8/100 person‐years, vs. 24%, 6.9/100 person‐years, P = 0.21). Although the incidence of HFH was lower in patients with HFpEF than in those with systolic HF (first procedure: 14%, 2.9/100 person‐years, vs. 24%, 5.7/100 person‐years, P = 0.07; last procedure: 11%, 2.5/100 person‐years, vs. 24%, 6.9/100 person‐years, P = 0.01), the incidence of CVH was higher (first procedure: 8%, 1.7/100 person‐years, vs. 5%, 1.2/100 person‐years, P = 0.74; last procedure: 6%, 1.4/100 person‐years, vs. 2%, 0.5/100 person‐years, P = 0.4). The number of HFH significantly decreased in both groups after CA (HFpEF: 1 hospitalization [the first and third quartiles: 0, 1] in pre‐CA, vs. 0 hospitalizations [0, 0] in post‐CA, P < 0.0001; systolic HF: 1 hospitalization [0, 1], vs. 0 hospitalizations [0, 0], P < 0.005). The proportion of HFH among total clinical events was significantly smaller in patients with HFpEF than in those with systolic HF (following the first procedure: 56% vs. 88%, P < 0.005; last procedure: 52% vs. 92%, P < 0.005).ConclusionsCA for AF could be beneficial for patients with HFpEF, similar to those with systolic HF. However, clinical events other than HFH should be considered cautiously in such patients.
Longitudinal trajectories in renal function before and after heart failure hospitalization among patients with heart failure with preserved ejection fraction in the PARAGON‐HF trial
Authors: Chatur Safia , Vaduganathan Muthiah , Peikert Alexander , Claggett Brian L. , McCausland Finnian R. , Skali Hicham , Pfeffer Marc A. , Beldhuis Iris E. , Kober Lars , Seferovic Petar , Lefkowitz Martin , McMurray John J.V. , Solomon Scott D. 
Published: July 2022

AimsWorsening renal function may impact long‐term outcomes in heart failure (HF). However, little is known about the longitudinal trajectories in renal function in relation to HF hospitalization or how this high‐risk clinical event impacts renal outcomes.Methods and resultsIn PARAGON‐HF, we evaluated the association between recency of prior HF hospitalization (occurring pre‐randomization) and subsequent first renal composite outcome: (i) time to ≥50% decline in estimated glomerular filtration rate (eGFR); (ii) development of end‐stage renal disease; or (iii) death attributable to renal causes. A total of 2306 (48.1%) patients had a history of prior HF hospitalization. Incident rates of the renal outcome were highest in those most recently hospitalized and decreased with longer time from last hospitalization. Treatment effect on the renal outcome of sacubitril/valsartan versus valsartan was similar between patients with (hazard ratio [HR] 0.43; 95% confidence interval [CI] 0.24–0.76) and without (HR 0.63; 95% CI: 0.33–1.18; pinteraction = 0.39) a prior history of HF hospitalization and appeared consistent regardless of timing of prior hospitalization for HF (pinteraction = 0.39). Serial eGFR measurements leading up to and after a HF hospitalization (occurring during the study period) and estimated eGFR trajectories using repeated measures regression models with restricted cubic splines were also examined. Patients experiencing a post‐randomization HF hospitalization had a significant decline in eGFR prior to hospitalization while patients without HF hospitalization experienced a relatively stable eGFR trajectory (p < 0.001). A change in the rate of decline of eGFR trajectory was observed 12 months preceding a HF hospitalization, and continued in the post‐discharge window to 12 months following hospitalization.ConclusionsHeart failure hospitalization denotes increased risk for kidney disease progression which continues following recovery from HF decompensation in patients with HF with preserved ejection fraction.Clinical Trial Registration: PARAGON‐HF (Prospective Comparison of ARNI with ARB Global Outcomes in HF with Preserved Ejection Fraction), ClinicalTrials.gov NCT01920711.
Real‐time droplet size analysis using laser micrometer as a process analytical technology tool for continuous dripping process
Authors: Wang Xiaoping , Tian Ying , Zhang Sheng , Qu Haibin 
Published: July 2022

AbstractProcess analysis and monitoring during the manufacturing of the dripping pills are essential. However, research on developing sensor‐based technology or process analytical technology (PAT) tools to analyze and monitor the dripping process is minimal. The purpose of this work is to develop a fast and non‐destructive laser detection system for quantitative visualization of droplets, which involves detecting the size of the droplet and calculating the weight of the dripping pills during the dripping process. Several factors influencing the detection performance of the detection system and the detection system capability for quantitation of the pill weight were explored. The laser detection system accurately detects the weight of the dripping pills with the coefficients of determination (R2) higher than 0.99. It was also robust concerning the variation in critical process parameters and critical material attributes. Furthermore, the laser detection system was successfully applied to the production line of Ginkgo biloba leaf dripping pills to monitor the dripping pills weight. The proposed laser detection system can analyze and monitor the dripping process in dripping pill manufacturing with stable performance, high accuracy, and high efficiency.