bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new exploration toward adamantane derivatives as potential anti‐MDR agents: Design, synthesis, antimicrobial, and radiosterilization activity as potential topoisomerase IV and DNA gyrase inhibitors
Authors: Ragab Ahmed , Abusaif Moustafa S. , Aboul‐Magd Dina S. , Wassel Mohammed M. S. , Elhagali Gameel A. M. , Ammar Yousry A. 
Published: June 2022

AbstractDeveloping novel antimicrobial agents has become a necessitate due to the increasing rate of microbial resistance to antibiotics. All the newly adamantane derivatives were evaluated for their antimicrobial activities against six MDR clinical pathogenic isolates. The results exhibited that 13 compounds have from potent to good activity. Among those, five derivatives (6, 7, 9, 14a, and 14b) displayed the potent activities against the different isolates tested (MIC < 0.25 µg/ml with bacteria and <8 µg/ml with fungi) compared with Ciprofloxacin (CIP) and Fluconazole (FCA). Additionally, the potent adamantanes showed bactericidal and fungicidal effects based on (MBCs and MFCs) and the time‐kill assay. The most active adamantane derivatives 7 and 14b exhibited a synergistic effect of ΣFIC ≤ 0.5 with CIP and FCA against the bacterial and fungal isolates. Moreover, no antagonistic effect appeared for the tested derivatives. Additionally, the interaction of DNA gyrase and topoisomerase IV enzymes with the compounds 6, 7, 9, 14a, and 14b exhibited potent antimicrobial activity using in vitro biochemical assays and gel‐based DNA‐supercoiling inhibition method. The activity of DNA gyrase and topoisomerase IV enzymes showed inhibitory activity (IC50) of 6.20 µM and 9.40 µM with compound 7 and 10.14 µM and 13.28 µM with compound 14b, respectively. Surprisingly, exposing compound 7 to gamma irradiation sterilized and increased its activity. Finally, the in‐silico analysis predicted that the most active derivatives had good drug‐likeness and safe properties. Besides, molecular docking and quantum chemical studies revealed several important interactions inside the active sites and showed the structural features necessary for activity.
A case report of olmesartan‐associated sprue‐like enteropathy: Diagnosis and healing confirmed by capsule endoscopy
Authors: Yamaguchi Yoshiharu , Miwa Takahiro , Murakami Ryo , Sugimura Akane , Yamamoto Kazuhiro , Sugiyama Tomoya , Tamura Yasuhiro , Izawa Shinya , Ebi Masahide , Funaki Yasushi , Ogasawara Naotaka , Sasaki Makoto , Kasugai Kunio 
Published: June 2022

AbstractHerein, we describe a case of olmesartan‐related sprue‐like enteropathy in which improvement in villous atrophy was confirmed by small‐bowel capsule endoscopy (CE). We successfully treated a 66‐year‐old man with a chief complaint of loose diarrhea. The patient had persistent watery diarrhea 10 times a day and experienced a weight loss of 9 kg in 3 months. An abdominal computed tomography scan showed fluid retention in the small intestine. Blood test results revealed no inflammatory reaction. Esophagogastroduodenoscopy detected villous atrophy in the stomach and duodenum. Moreover, small‐bowel CE showed villous atrophy in about two‐thirds of the small intestine. Based on other examinations, hyperthyroidism, intestinal tuberculosis, intestinal amyloidosis, and intestinal malignant lymphoma were ruled out. Therefore, the patient was suspected of having an olmesartan‐related sprue‐like disease. Early after discontinuation of medication, diarrhea symptoms improved, and a repeat CE indicated improvements in small intestinal villous atrophy. Since the patient had been administered olmesartan for a long time and CE showed villous atrophy throughout the small bowel, we suspected him of having the olmesartan‐associated sprue‐like disease. The findings of gastric mucosa atrophy on esophagogastroduodenoscopy may lead to an early diagnosis of this disease. Olmesartan‐related sprue‐like enteropathy should be considered as a differential diagnosis in patients with chronic severe watery diarrhea.
Adolescents with type 1 diabetes can achieve glycemic targets on intensive insulin therapy without excessive weight gain
Authors: Marlow Alexandra L. , King Bruce R. , Phelan Helen T. , Smart Carmel E. 
Published: June 2022

AbstractIntroductionThe aim of this study was to compare glycemic control and body mass index standard deviation score (BMI‐SDS) before and after implementation of intensive insulin therapy using multiple daily injection (MDI) or continuous subcutaneous insulin infusion (CSII) in adolescents with type 1 diabetes (T1D) attending a large multidisciplinary paediatric diabetes clinic in Australia.MethodsProspective data were collected for cross‐sectional comparison of youth aged 10.0–17.9 years (n = 669) from routine follow‐up visits to the diabetes clinic in 2004, 2010, and 2016. Outcome measures included HbA1c; BMI‐SDS; and insulin regimen.ResultsBMI‐SDS remained stable between 2004 to 2016 in the 10–13 and 14–17 year age group (0.7 vs. 0.5, p = .12 and 0.7 vs. 0.7, p = .93, respectively). BMI‐SDS was not different across HbA1c groups; <53 mmol/mol (7.0%), 53 to <75 mmol/mol (<7.0 to <9.0%) and >75 mmol/mol (>9.0%) in 2004 (p = .873), 2010 (p = .10) or 2016 (p = .630). Mean HbA1c decreased from 2004 to 2016 in the 10–13 year (69 mmol/mol (8.4%) vs. 57 mmol/mol (7.4%), p = <.001) and 14–17 year group (72 mmol/mol (8.7%) vs. 63 mmol/mol (7.9%), p = <.001). Prior to the implementation of MDI and CSII in 2004 only 10% of 10–13 year olds and 8% of 14–17 year olds achieved the international target for glycemic control (HbA1c 53 mmol/mol [<7.0%]). In 2016, this increased to 31% of 10–13 year olds and 21% of 14–17 year olds.ConclusionsBMI‐SDS did not increase with the change to intensive insulin therapy despite a doubling in the number of adolescents achieving the recommended glycemic target of <7.0% (53 mmol/mol). HbA1c was not associated with weight gain.
Analysis of French forest policy in the context of ecosystem services: From the national to the regional level
Authors: Ambroise Lison , Abildtrup Jens , Pülzl Helga 
Published: June 2022

AbstractEcosystem service research has been steadily growing and has gone beyond the scope of conceptual understanding and methodological approaches. Overall, less research has been devoted to how and to what degree the ecosystems service concept has been adopted in policy‐making. This study analyses how forests and forest ecosystem services are framed in official French documents. A frame analysis was carried out on 26 documents (related to forest, biodiversity, energy, bioeconomy and climate policies) using ATLAS.ti software. The analysis was conducted at the national and regional levels (Grand Est region) in order to compare potential framing differences. It was supplemented with qualitative expert interviews to cross‐validate frames and to investigate the relative importance given to each frame by key stakeholders at the regional and national levels. The analysis resulted in the reconstruction of 12 frames. The two most important frames at the national level are ‘Forests as providers of wood and material’ and ‘Forests as a means of mitigating climate change’. In the Grand Est region, the latter frame is less important than frames related to the role of forests with regard to the quality of human life and recreation. This may be explained by the fact that public ownership is predominant in the Grand Est region. While the multifunctionality of the forest is rarely mentioned in policy documents, interviews revealed that the multifunctionality of forests remains an important concept among policy‐makers, even if it is not always explicitly mentioned and is losing ground to the ecosystem services concept.
Impact of patient engagement in a French telemonitoring programme for heart failure on hospitalization and mortality
Authors: Sabatier Rémi , Legallois Damien , Jodar Mouna , Courouve Laurène , Donio Valérie , Boudevin Florence , De Chalus Thibault , Hauchard Karine , Belin Annette , Milliez Paul 
Published: June 2022

AbstractAimsManagement of patients with recently decompensated heart failure by hospital services is expensive, complicated to plan, and not always effective. Telemedicine programmes in heart failure may improve the quality of care, but their effectiveness is poorly documented in real‐world settings. The study aims to evaluate the impact of patient engagement in home‐based telemonitoring for heart failure (SCAD programme) on rehospitalization and mortality rates.Methods and resultsA retrospective observational study was performed in 659 SCAD participants. SCAD is a patient‐oriented service of home‐based interactive telemonitoring offered to heart failure patients during hospitalization who agree to participate in a therapeutic education programme. Patients were telemonitored for at least 3 months, and rehospitalization and mortality were documented at 12 months and 5 years. During the telemonitoring period, patients provided daily information on health and lifestyle through an internet‐based interface. Data were linked on a patient‐by‐patient basis between the SCAD database and the French national health insurance database (Système National des Données de Santé). Outcomes were compared as a function of use of the programme. Low, intermediate, and high users were classified by tercile of data return during telemonitoring. Patients were followed for a median of 32.9 months. Rehospitalization rates for cardiovascular disease decreased from 79.4% in the year preceding enrolment to 41.1% in the following year and from 52.8% to 18.8% for hospitalizations for heart failure. The 12 month mortality rate was 11.2%. Significant associations were observed between level of use of the SCAD programme and all‐cause rehospitalization (P = 0.0085), rehospitalization for cardiovascular disease (P = 0.0010), rehospitalization for heart failure (27.8% in low users, 12.9% in intermediate users, and 13.5% in high users; P < 0.0001), and mortality (26.8%, 15.2%, and 15.9% respectively; P = 0.0157) in the 12 months following enrolment. The mean number of days alive outside hospital were 279 ± 111 in low users, 312 ± 90 in intermediate users, and 304 ± 100 in high users (P = 0.0022).ConclusionsEducational home telemonitoring of patients with heart failure following hospitalization provides long‐term clinical benefits in terms of rehospitalization and death in real‐world settings, according to the level of use of the programme by the patient. These benefits would be expected to have a major impact on the burden of this disease. Low engagement in telemonitoring could be used as a signal of poor prognosis and taken into account in the management strategy.
Combined mechanical circulatory support for ventricular fibrillation in left ventricular assist device patient
Authors: Abu Akel Mahmood , Shaul Aviv A. , Goldenberg Gustavo R. , Barac Yaron D. , Ben‐Avraham Binyamin , Gorfil Dan , Aravot Dan , Ben‐Gal Tuvia 
Published: June 2022

AbstractVentricular fibrillation, a life‐threatening ventricular arrhythmia, may result in pulselessness, loss of consciousness and sudden cardiac death. In this case report, we describe our experience in managing a 54‐year‐old man with HeartMate3 left ventricular assist device (LVAD) as a bridge to transplantation due to dilated non‐ischemic cardiomyopathy, presenting with incessant ventricular arrhythmia for 35 days despite multiple attempts to restore normal rhythm with external direct current cardioversion and anti‐arrhythmic medications. The patient remained stable in ventricular arrhythmia with no progression to asystole, but hemodynamic collapse due to right heart failure occurred in the third week. Combined use of two mechanical circulatory support devices (LVAD with VA ECMO) was needed to achieve haemodynamic and metabolic stability, eventually leading to successful heart transplantation in the index admission. The patient was discharged home 2 weeks after transplantation in good clinical condition.
An Adenine‐Based Biological Metal‐Organic Framework as an Efficient Luminescent Sensor for Tetracycline Detection
Authors: Wu Xia , Xiong Xiao , Li Jia‐Li , Luo Dong , Wu Kun , Wei Yu‐Bai , Liu Xin‐Yi , Lu Weigang , Li Dan , He Jian 
Published: June 2022

AbstractBecause of their misuse and poor management, antibiotics pose a significant threat to the ecological environment and human health. The development of highly sensitive and effective sensors to detect such environmental contaminants is a crucial and challenging task. As a new class of desirable biocompatible materials, biological metal‐organic frameworks are considered as a viable platform for sensing applications. Herein, we report the synthesis of biological luminescent metal‐organic framework [Zn6Ad4(BPDC‐(OH)2)4]n (JNU‐104) using adenine (Ad) and 2,2′‐dihydroxy‐1,1′‐biphenyl‐4,4′‐dicarboxylic acid [BPDC‐(OH)2] as organic linkers. JNU‐104 serves as a robust and sensitive luminescent sensor for detecting tetracycline antibiotics in aqueous media with low limits of detection (LODs) of 0.023, 0.029 and 0.024 μM for tetracycline (TC), oxytetracycline (OTC), and chlortetracycline (CTC), respectively. Furthermore, the MOF‐based test strips show a rapid and visualizable luminescence response to tetracycline antibiotics, making JNU‐104 a promising candidate for practical applications in sensing.
A multi‐perspective framework for seismic retrofit optimization of urban infrastructure systems
Authors: Liu Chuang , Ouyang Min , Mao Zijun , Xu Xiaolin 
Published: June 2022

AbstractUrban infrastructure systems play essential roles in the smooth functioning of modern society but are also threatened by seismic hazards in the earthquake‐prone areas. Retrofitting critical components of those systems has been considered as the most frequently used mitigation strategy in both the literature and practice. The seismic retrofit budget is usually limited, then it needs to identify a set of critical components to be retrofitted, which is generally formulated as a seismic retrofit optimization problem. This article proposes a multi‐perspective modeling and solution framework for the seismic retrofit optimization of urban infrastructure systems, which allows choosing different performance measures including vulnerability, resilience loss and economic loss as the objective function. The proposed framework can be used to explore how different performance measures and the infrastructure interdependencies affect the seismic retrofit decision. Taking the interdependent Shelby power and gas systems as an example, results show that if considering single systems, the optimal economic loss‐based performance improvement ratio (PIR) is larger than the best resilience loss‐based PIR, which is larger than the vulnerability‐based PIR; if considering interdependent systems, the interdependency intensity is indeed a key factor affecting the retrofit decision.
H2RUN: An efficient vendor lock‐in solution for multi‐cloud environment using horse herd Runge Kutta based data placement optimization
Authors: Hari Kumar P , Mala G. S. Anandha 
Published: June 2022

AbstractVendor lock‐in is a scenario where the cost of switching to another vendor is mainly high and for this reason, the consumer is mainly struck with a single cloud vendor. The vendor lock‐in mainly implies the situation of an organization where it is locked into a service or product of a single Cloud Service Providers (CSP) to prevent the disruption of the business operation or due to an insufficient workforce. Due to its high availability, portability, and other benefits, various researchers frequently adopt the multi‐cloud strategy to prevent vendor lock‐in. However, the multi‐cloud architecture also comes with major drawbacks such as cost, multiple CSP management, and the tradeoff between cost and availability. The organizations are mainly considerate about achieving the tradeoff between the cost and availability. To overcome this problem, we have proposed an H2RUN (Horse Herd Runge Kutta) optimization algorithm to achieve a tradeoff between the cost and availability using erasure coding. The proposed H2RUN optimization algorithm selects the optimal CSP and erasure coding parameters that enhance the availability of the CSP with minimal cost. The efficiency of the proposed methodology can be evaluated using the experiments conducted on different real‐time CSPs using various metrics. Based on the results achieved, the H2RUN optimizer minimizes the cost up to 48% and availability up to 58%.
A systematic survey of data mining and big data in human behavior analysis: Current datasets and models
Authors: Ding Xuefeng , Gan Qihong , Bahrami Sara 
Published: June 2022

AbstractIn recent years, understanding human behavior has become one of the most important topics in the field of computer vision research. The reason for this growing attention is the wide range of applications that can benefit from the results of this field of research. The human behavior analysis (HBA) includes a wide range of research areas from the detection of human motion and action. Datasets created through actions and detection of human activities make it possible to compare different detection methods with the same input data. Data mining and big data approaches are very popular for analyzing data related to human behavior and can be used to address the challenges of fast processing. This article provides a systematic survey of data mining and big data in the HBA. We focus on current datasets and models related to the detection of human behavior patterns in the literature. The purpose of this survey is to assist researchers in select appropriate datasets and models to evaluate algorithms, as well as to identify research gaps for future work. To achieve this goal, articles published between 2010 and 2021 have been reviewed. These articles fall into five general categories in terms of dataset focus: object detection, motion, action, activity, and behavior. This article provides a summary of data mining and big data models in the HBA, as well as related datasets based on these categories, to highlight promising research avenues for future work.
A modified global neighborhood algorithm for designing labeling diversity mappers
Authors: Solwa Shaheen , Olayinka Ayanda Dauda 
Published: June 2022

AbstractGenetic algorithms (GAs) have been recently applied to uncoded space‐time labeling diversity systems (USTLD) to improve upon diversity in wireless links. GAs were used to optimize the secondary mappers that are used to encode the information to be transmitted. Existing literature only achieved a local optimal design, at the fraction of the computational costs. Hence, this article focuses on improving upon the GAs for USTLD systems by merging it with a global‐local search technique, called the global neighborhood algorithm (GNA). The GNA algorithm was tested on M‐QAM, M‐PSK, M‐APSK, and asymmetric M‐APSK constellations of modulation order M , and . In the case of M‐QAM constellations, the GNA was able to match, but not improve upon existing mapper designs. In the case of the 64PSK constellation, the GNA was able to produce mapper designs that improved upon the error performance of existing mapper designs by approximately 1 dB. In the case of the 32APSK constellation, the GNA was able to improve upon the error performance of existing mapper designs by approximately 0.5 dB. Moreover, the GNA produced mapper designs for the 11+5APSK and asymmetric 16APSK constellations that improved upon the error performance of existing mapper designs by approximately 0.5 and 4 dB respectively. Finally, the computational complexity of the proposed GNA algorithm was analyzed and the algorithm was shown to be which is slightly more complex than the initial GA approach with complexity , but significantly less complex than the enhanced GA with complexity . The increased complexity also came with significant gains such as improved LD mapper designs.
Central nervous system sarcoma with ATXN1::DUX4 fusion expands the concept of CIC‐rearranged sarcoma
Authors: Satomi Kaishi , Ohno Makoto , Kubo Takashi , Honda‐Kitahara Mai , Matsushita Yuko , Ichimura Koichi , Narita Yoshitaka , Ichikawa Hitoshi , Yoshida Akihiko 
Published: June 2022

AbstractCIC‐rearranged sarcoma is a high‐grade sarcoma, most often harboring CIC::DUX4 fusion, and is characterized by a distinct round cell histology, co‐expression of ETV4 and WT1, and a specific DNA methylation class. Herein, we report a brain tumor with ATXN1::DUX4 that had an indistinguishable phenotype and DNA methylation profile from CIC‐rearranged sarcoma. A 40‐year‐old man presented with a 5 cm hemorrhagic mass in the right frontal lobe of the cerebrum. The tumor was resected and histologically showed a dense proliferation of relatively monomorphic round cells with multifocal myxoid changes. Immunohistochemically, the tumor was diffusely positive for ETV4, WT1, and DUX4. Through classic histomorphology and immunoprofile, the tumor was provisionally diagnosed as CIC‐rearranged sarcoma. However, no CIC fusions or mutations were identified using CIC break‐apart fluorescence in situ hybridization (FISH) or FoundationOne CDx. Despite multiple surgeries and adjuvant chemoradiation therapy, the patient succumbed 16 months after presentation. RNA exome sequencing detected an in‐frame intraexonic ATXN1 (exon 9)::DUX4 (exon 1) fusion, which was validated by reverse transcription‐polymerase chain reaction and ATXN1 FISH assay. Upon DNA methylation analysis, the tumor matched with CIC‐rearranged sarcoma both by the Deutsche Krebsforschungszentrum classifier and t‐distributed stochastic neighbor embedding. Along with a recent report of a similar pediatric brain tumor, the present case suggests that ATXN1::DUX4 is a recurrent alternative molecular event in the sarcoma type that is presently defined by CIC rearrangement, which prompts an expansion of the tumor concept.
Infantile metastatic ependymoma with a novel molecular profile and favorable outcome to intensive chemotherapy without irradiation: Case‐based review
Authors: De Faria Flavia Watusi , Schieffer Kathleen M. , Pierson Christopher R. , Boue Daniel R. , LaHaye Stephanie , Miller Katherine E. , Amayiri Nisreen , Koboldt Daniel C. , Lichtenberg Tara , Leraas Kristen , Brennan Patrick , Kelly Ben , White Peter , Magrini Vincent , Wilson Richard K. , Mardis Elaine R. , Cottrell Catherine E. , Rusin Jerome , Finlay Jonathan L. , Osorio Diana S. 
Published: June 2022

AbstractEpendymal tumors are the third most common brain tumor under 14 years old. Even though metastatic disease is a rare event, it affects mostly young children and carries an adverse prognosis. The factors associated with dissemination and the best treatment approach have not yet been established and there is limited published data on how to manage metastatic disease, especially in patients under 3 years of age. We provide a review of the literature on clinical characteristics and radiation‐sparing treatments for metastatic ependymoma in children under 3 years of age treated. The majority (73%) of the identified cases were above 12 months old and had the PF as the primary site at diagnosis. Chemotherapy‐based approaches, in different regimens, were used with radiation reserved for progression or relapse. The prognosis varied among the studies, with an average of 50%–58% overall survival. This study also describes the case of a 7‐month‐old boy with metastatic posterior fossa (PF) ependymoma, for whom we identified a novel SPECC1L‐RAF1 gene fusion using a patient‐centric comprehensive molecular profiling protocol. The patient was successfully treated with intensive induction chemotherapy followed by high‐dose chemotherapy and autologous hematopoietic progenitor cell rescue (AuHSCR). Currently, the patient is in continuous remission 5 years after his diagnosis, without radiation therapy. The understanding of the available therapeutic approaches may assist physicians in their management of such patients. This report also opens the perspective of newly identified molecular alterations in metastatic ependymomas that might drive more chemo‐sensitive tumors.