bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammation and atherosclerosis: signaling pathways and therapeutic intervention
Authors: Kong Peng , Cui Zi-Yang , Huang Xiao-Fu , Zhang Dan-Dan , Guo Rui-Juan , Han Mei 
Published: April 2022

AbstractAtherosclerosis is a chronic inflammatory vascular disease driven by traditional and nontraditional risk factors. Genome-wide association combined with clonal lineage tracing and clinical trials have demonstrated that innate and adaptive immune responses can promote or quell atherosclerosis. Several signaling pathways, that are associated with the inflammatory response, have been implicated within atherosclerosis such as NLRP3 inflammasome, toll-like receptors, proprotein convertase subtilisin/kexin type 9, Notch and Wnt signaling pathways, which are of importance for atherosclerosis development and regression. Targeting inflammatory pathways, especially the NLRP3 inflammasome pathway and its regulated inflammatory cytokine interleukin-1β, could represent an attractive new route for the treatment of atherosclerotic diseases. Herein, we summarize the knowledge on cellular participants and key inflammatory signaling pathways in atherosclerosis, and discuss the preclinical studies targeting these key pathways for atherosclerosis, the clinical trials that are going to target some of these processes, and the effects of quelling inflammation and atherosclerosis in the clinic.
Synthetic bacterial community derived from a desert rhizosphere confers salt stress resilience to tomato in the presence of a soil microbiome
Authors: Schmitz Lucas , Yan Zhichun , Schneijderberg Martinus , de Roij Martijn , Pijnenburg Rick , Zheng Qi , Franken Carolien , Dechesne Annemarie , Trindade Luisa M , van Velzen Robin , Bisseling Ton , Geurts Rene , Cheng Xu 
Published: April 2022

Abstract
The root bacterial microbiome is important for the general health of the plant. Additionally, it can enhance tolerance to abiotic stresses, exemplified by plant species found in extreme ecological niches like deserts. These complex microbe-plant interactions can be simplified by constructing synthetic bacterial communities or SynComs from the root microbiome. Furthermore, SynComs can be applied as biocontrol agents to protect crops against abiotic stresses such as high salinity. However, there is little knowledge on the design of a SynCom that offers a consistent protection against salt stress for plants growing in a natural and, therefore, non-sterile soil which is more realistic to an agricultural setting. Here we show that a SynCom of five bacterial strains, originating from the root of the desert plant Indigofera argentea, protected tomato plants growing in a non-sterile substrate against a high salt stress. This phenotype correlated with the differential expression of salt stress related genes and ion accumulation in tomato. Quantification of the SynCom strains indicated a low penetrance into the natural soil used as the non-sterile substrate. Our results demonstrate how a desert microbiome could be engineered into a simplified SynCom that protected tomato plants growing in a natural soil against an abiotic stress.
Microbiome and related structural features of Earth’s most archaic plant indicate early plant symbiosis attributes
Authors: Satjarak Anchittha , Golinski G. Karen , Trest Marie T. , Graham Linda E. 
Published: April 2022

AbstractOrigin of earliest land plants from ancestral algae dramatically accelerated the evolution of Earth’s terrestrial ecosystems, in which microbial symbioses have played key roles. Recent molecular diversification analyses identify the rare, geographically-limited mossTakakiaas Earth’s most archaic modern land plant. Despite occupying a phylogenetic position pivotal for understanding earliest plants,Takakiamicrobial associations are poorly known. Here, we describe symbiosis-related structural features and contig-based metagenomic data that illuminate the evolutionary transition from streptophyte algae to early embryophytes. We observed thatT. lepidozioidesshares with streptophyte algae secretion of microbe-harboring mucilage and bacterial taxa such asRhizobiumand genes indicating nitrogen fixation. We find thatTakakia root-analogs produce lateral mucilage organs that are more complex than generally understood, having structural analogies to angiosperm lateral roots adapted for N-fixation symbioses, including presence of intracellular microbes. We also find structural and metagenomic evidence for mycorrhiza-like species of glomalean fungi (includingRhizophagus irregularis) not previously known for mosses, as well as ascomycete fungi (e.g.Rhizoscyphus ericae) that associate with other early-diverging plants. BecauseTakakiais the oldest known modern plant genus, this study of plants of a remote locale not strongly influenced by human activities may indicate microbiome features of early land plants.
An insight into tetracycline photocatalytic degradation by MOFs using the artificial intelligence technique
Authors: Gheytanzadeh Majedeh , Baghban Alireza , Habibzadeh Sajjad , Jabbour Karam , Esmaeili Amin , Mohaddespour Ahmad , Abida Otman 
Published: April 2022

AbstractTetracyclines (TCs) have been extensively used for humans and animal diseases treatment and livestock growth promotion. The consumption of such antibiotics has been ever-growing nowadays due to various bacterial infections and other pathologic conditions, resulting in more discharge into the aquatic environments. This brings threats to ecosystems and human bodies. Up to now, several attempts have been made to reduce TC amounts in the wastewater, among which photocatalysis, an advanced oxidation process, is known as an eco-friendly and efficient technology. In this regard, metal organic frameworks (MOFs) have been known as the promising materials as photocatalysts. Thus, studying TC photocatalytic degradation by MOFs would help scientists and engineers optimize the process in terms of effective parameters. Nevertheless, the costly and time-consuming experimental methods, having instrumental errors, encouraged the authors to use the computational method for a more comprehensive assessment. In doing so, a wide-ranging databank including 374 experimental data points was gathered from the literature. A powerful machine learning method of Gaussian process regression (GPR) model with four kernel functions was proposed to estimate the TC degradation in terms of MOFs features (surface area and pore volume) and operational parameters (illumination time, catalyst dosage, TC concentration, pH). The GPR models performed quite well, among which GPR-Matern model shows the most accurate performance with R2, MRE, MSE, RMSE, and STD of 0.981, 12.29, 18.03, 4.25, and 3.33, respectively. In addition, an analysis of sensitivity was carried out to assess the effect of the inputs on the TC photodegradation by MOFs. It revealed that the illumination time and the surface area play a significant role in the decomposition activity.
Diagnostic and prognostic value of urine biomarkers among women with dysfunctional voiding
Authors: Jiang Yuan-Hong , Jhang Jia-Fong , Ho Han-Chen , Hsu Yung-Hsiang , Kuo Hann-Chorng 
Published: April 2022

AbstractThe current study aimed to investigate the diagnostic and prognostic value of urine biomarkers among female patients with dysfunctional voiding (DV). Urine samples were collected from 43 female patients with DV and 25 controls. Oxidative stress biomarkers (8-hydroxy-2-deoxyguanosine [8-OHdG], 8-isoprostane, and total antioxidant capacity [TAC]) and inflammatory markers (interleukin-1 beta [IL-1β], IL-2, IL-6, IL-8, tumor necrosis factor alpha, nerve growth factor, and brain-derived neurotrophic factor) levels were analyzed. In total, 26 patients with DV received further treatment with biofeedback pelvic floor muscle exercise or external urethral sphincter botulinum toxin A injections. Patients with DV had significantly higher urine 8-OHdG, IL-1β, IL-8, and brain-derived neurotrophic factor levels than controls. Both urine 8-OHdG and IL-1β levels were positively correlated with clinical symptoms. Patients with DV who had successful treatment outcomes had significantly lower pretreatment urine 8-isoprostane and TAC levels than those with unsuccessful outcomes. The pretreatment urine TAC level was the only independent predictor of successful treatment outcomes (odds ratio: 0.995). Compared with controls, female patients with DV had distinct urine oxidative stress biomarker and inflammatory marker profiles, which also mapped their clinical characteristics and treatment outcomes. These urine analytes might have diagnostic and prognostic values among female patients with DV.
An investigation on catalytic nitrite reduction reaction by bioinspired CuII complexes
Authors: Chang Yu-Lun , Chen Hsing-Yin , Chen Si-Hong , Kao Chai-Lin , Chiang Michael Y. , Hsu Sodio C. N. 
Published: April 2022

Catalytic nitrite reductions by CuII complexes containing anionic Me2Tp, neutral Me2Tpm, or neutral iPrTIC ligands in the presence of l-ascorbic acid, which served as an electron donor and proton source, were investigated.
Predicting Lyman-continuum emission of galaxies using their physical and Lyman-alpha emission properties
Authors: Maji Moupiya , Verhamme Anne , Rosdahl Joakim , Garel Thibault , Blaizot Jérémy , Mauerhofer Valentin , Pittavino Marta , Victoria Feser Maria-Pia , Chuniaud Mathieu , Kimm Taysun , Katz Harley , Haehnelt Martin 
Published: April 2022

Aims.The primary difficulty in understanding the sources and processes that powered cosmic reionization is that it is not possible to directly probe the ionizing Lyman-continuum (LyC) radiation at that epoch as those photons have been absorbed by the intervening neutral hydrogen. It is therefore imperative to build a model to accurately predict LyC emission using other properties of galaxies in the reionization era.Methods.In recent years, studies have shown that the LyC emission from galaxies may be correlated to their Lyman-alpha (Lyα) emission. In this paper we study this correlation by analyzing thousands of simulated galaxies at high redshift in the SPHINX cosmological simulation. We post-process these galaxies with the Lyαradiative transfer code RASCAS and analyze the Lyα– LyC connection.Results.We find that the Lyαand LyC luminosities are strongly correlated with each other, although with dispersion. There is a positive correlation between the escape fractions of Lyαand LyC radiations in the brightest Lyman-alpha emitters (LAEs; escaping LyαluminosityLescLyα> 1041erg s−1), similar to that reported by recent observational studies. However, when we also include fainter LAEs, the correlation disappears, which suggests that the observed relation may be driven by selection effects. We also find that the brighter LAEs are dominant contributors to reionization, withLescLyα> 1040erg s−1galaxies accounting for > 90% of the total amount of LyC radiation escaping into the intergalactic medium in the simulation. Finally, we build predictive models using multivariate linear regression, where we use the physical and Lyαproperties of simulated reionization era galaxies to predict their LyC emission. We build a set of models using different sets of galaxy properties as input parameters and predict their intrinsic and escaping LyC luminosity with a high degree of accuracy (the adjustedR2of these predictions in our fiducial model are 0.89 and 0.85, respectively, whereR2is a measure of how much of the response variance is explained by the model). We find that the most important galaxy properties for predicting the escaping LyC luminosity of a galaxy are itsLescLyα, gas mass, gas metallicity, and star formation rate.Conclusions.These results and the predictive models can be useful for predicting the LyC emission from galaxies using their physical and Lyαproperties and can thus help us identify the sources of reionization.
Hämodynamisches Monitoring 2.0 – was ist auf Normalstation möglich?
Authors: Schiewe Robert , Bein Berthold 
Published: April 2022

ZusammenfassungNeben der Verwendung von Scores zur Früherkennung sich kritisch verschlechternder Patienten kann die Patientensicherheit durch zusätzliches Monitoring auch auf der Normalstation erhöht
werden. Hierbei ist die Praktikabilität von entscheidender Bedeutung, wodurch die Auswahl geeigneter nichtinvasiver Verfahren im Rahmen der Behandlung auf Normalstation eingeschränkt
ist.
Valproic Acid Initiates Transdifferentiation of the Human Ductal
Adenocarcinoma Cell-line Panc-1 Into α-Like Cells
Authors: Petry Sebastian Friedrich , Kandula Naga Deepa , Günther Stefan , Helker Christian , Schagdarsurengin Undraga , Linn Thomas 
Published: April 2022

AbstractNon-mesenchymal pancreatic cells are a potential source for cell replacement.
Their transdifferentiation can be achieved by triggering epigenetic remodeling
through e. g. post-translational modification of histones. Valproic
acid, a branched-chain saturated fatty acid with histone deacetylase inhibitor
activity, was linked to the expression of key transcription factors of
pancreatic lineage in epithelial cells and insulin transcription. However, the
potential of valproic acid to cause cellular reprogramming is not fully
understood. To shed further light on it we employed next-generation RNA
sequencing, real-time PCR, and protein analyses by ELISA and western blot, to
assess the impact of valproic acid on transcriptome and function of
Panc-1-cells. Our results indicate that valproic acid has a significant impact
on the cell cycle, cell adhesion, histone H3 acetylation, and metabolic pathways
as well as the initiation of epithelial-mesenchymal transition through
acetylation of histone H3 resulting in α-cell-like characteristics. We
conclude that human epithelial pancreatic cells can be transdifferentiated into
cells with endocrine properties through epigenetic regulation by valproic acid
favoring an α-cell-like phenotype.
Therapie der Sialorrhoe mit Botulinumtoxin – ein
Update
Authors: Jost Wolfgang H. , Bäumer Tobias , Berweck Steffen , Laskawi Rainer , Spittau Björn , Steffen Armin , Winterholler Martin 
Published: April 2022

ZusammenfassungDie größten Speicheldrüsen sind die paarigen Gl. parotis
und Gl. submandibularis. Der erwachsene Mensch produziert
1–1,5 l Speichel am Tag, die er regelmäßig
abschluckt. Die häuﬁgste Ursache eines vermehrten
Speichelﬂusses mit einer Ansammlung von Speichel im Mund und
Ausﬂuss (Sialorrhoe) ist eine Störung der Schluckfunktion.
Seltener kann auch eine vermehrte Speichelsekretion, z. B.
medikamentös bedingt, die Ursache sein. Eine Sialorrhoe
beeinträchtigt die Lebensqualität erheblich und ist oft auch
sozial stigmatisierend. Die Therapie umfasst konservative Maßnahmen wie
die funktionelle Dysphagietherapie, orale oder transdermale Applikation von
Anticholinergika sowie, in ausgewählten Fällen, invasive
Therapien wie Bestrahlungen und Operationen. Seit 20 Jahren wird auch die lokale
Injektion von Botulinumtoxin in die Speicheldrüsen erfolgreich
therapeutisch eingesetzt. Durch die Zulassung von IncobotulinumtoxinA
für die Behandlung von Kindern und Erwachsenen darf diese
Maßnahme als Therapie der Wahl bei chronischer Sialorrhoe angesehen
werden. Die Ergebnisse der Zulassungsstudien zeigen bei Kindern wie auch
Erwachsenen eine hohe Effektivität und gute Verträglichkeit der
Injektionsbehandlung.
Behandlung der Sialorrhoe mit Botulinum Neurotoxin Typ A –
Konsentierte Praxisempfehlungen für Kinder und
Erwachsene
Authors: Jost Wolfgang H. , Bäumer Tobias , Bevot Andrea , Birkmann Ulrich , Buhmann Carsten , Grosheva Maria , Guntinas-Lichius Orlando , Mlynczak Ute , Paus Sebastian , Pflug Christina , Schröder Sebastian , Steffen Armin , Wilken Bernd , Berweck Steffen 
Published: April 2022

ZusammenfassungSialorrhoe, ein unkontrollierter, übermäßiger
Speichelfluss aus dem Mund und in den Schlund, tritt als Begleitsymptom bei
verschiedenen, v. a. neurologischen Erkrankungen im Kindes- und
Erwachsenenalter auf. Mit IncobotulinumtoxinA (Xeomin, IncoBoNT/A,
Merz Pharmaceuticals GmbH) steht seit 2019 ein zugelassenes Medikament
für die Behandlung der Sialorrhoe zur Verfügung.
Indikationsstellung, mögliche Therapieziele, Praxis der Behandlung und
Management in besonderen Behandlungssituationen bilden den Schwerpunkt dieser
konsentierten Praxis-Empfehlungen, die in interdisziplinärer
Zusammenarbeit erfahrener Anwender entwickelt wurden. Ziel ist, den Zugang zur
Therapie zu erleichtern und einen Beitrag zu einer qualifizierten
Botulinumtoxin-Therapie zu leisten.
Metabolic Status Modulates Choroidal Thickness – A Possible
Early Indicator for Diabetic Eye Complications?
Authors: Meyhöfer Svenja , Wilms Britta , Chamorro Rodrigo , Knaak Armin , Pappa Eleni , Schulz Agnetha S. , Pagels Anna-Josephin , Schröder Maria , Kaluzny Neele , Grein Hans-Jürgen , Meyhöfer Sebastian M. 
Published: April 2022

Abstract
Objective To investigate the impact of metabolic status on choroidal
thickness (ChT) in healthy subjects, patients with obesity, and type 2
diabetes.
Design and Methods Fasting blood glucose, insulin, insulin-like growth
factor-1 (IGF-1), and ChT measured by optical coherence tomography were assessed
in healthy normal-weight (n=17), obese participants (n=20), and
obese participants with T2D (n=16).
Results ChT increased in obese participants and obese participants with
T2D as compared to healthy normal-weight participants (P<0.0001). A
negative correlation was observed between IGF1 and ChT
(r=−0.268, P=0.050) for all cohorts. Furthermore, body
mass index (BMI; R2=0.209; P=0.002;
beta=0.388) and model assessment-estimated insulin resistance (HOMA-IR;
R2=0.074; P=0.015; beta=0.305) were
independent variables of ChT, explaining 20.9 and 7.4% of its variance
(both p<0.016), whereas age, sex, and IGF-1 were not significant
confounders of ChT (p>0.975).
Conclusion ChT is associated with metabolic characteristics,
i. e., BMI and HOMA-IR. Due to the key role of choroidal function in
retinal physiology, future studies are needed to evaluate whether metabolic
traits, ChT, and potential metabolic eye complications are mechanistically
linked.
Knowledge, Attitude, and Practices of Parents toward Pediatric Dental Radiography
Authors: Sreenivasan Sanjna K. , Lolayekar Nikita , Sheth Priyal , Rao Dipasha 
Published: April 2022

AbstractBackground Pediatric dental radiography is a field with numerous uses as well as concerns regarding radiation safety. This study was undertaken to assess the knowledge that parents have regarding the same. This questionnaire survey was conducted with the aim of assessing the knowledge, attitude, and practices of parents toward pediatric dental radiography.Material and Methods In total, 280 questionnaires were answered by parents of children visiting the Pediatric Dental Department. The first 10 questions served to evaluate the knowledge and attitude of parents toward pediatric dental radiography. The last three questions were designed to assess the practices of parents in relation to dental radiography and protective gear. The answers were collected and analyzed.Results From the survey it was seen that most parents were aware that the harmful effects from dental radiography were minimal (51%). A fairly significant number of parents lacked the knowledge regarding the harmful effects of dental radiography in children compared to adults (63%), in comparison to the harmful effects from cell phones (66%) and in comparison to harmful effects of medical radiography (42%). A fair number of parents seemed to be aware of the detrimental cumulative nature (47%) of radiation. It was found that a large number of parents do not ask for an explanation regarding the need for the dental radiograph for their children before the dental treatment (50%). Most parents (64%) were not aware of the availability of protective gear and very few (16%) requested for it.Conclusion The parents considered in this study had appreciable knowledge and a positive attitude toward dental radiography. However, a significant lack of knowledge regarding protective gear used for dental radiography among these parents was identified from this study.
Generation of double Holliday junction DNAs and their dissolution/resolution within a chromatin context
Authors: Ho Han N. , West Stephen C. 
Published: April 2022

Significance
We devised a method involving DNAzyme self-cleavage for the preparation of DNA molecules containing double Holliday junctions (dHJs) that are separated by 746 bp. The DNAs can be prepared in large amounts suitable for in vitro analysis of enzymes required for the processing of recombination intermediates. We show that the dHJ DNA is dissolved efficiently by the BLM–TopIIIα–RMI1–RMI2 (BTRR) complex to produce noncrossover products, whereas nucleolytic resolution by GEN or SMX results in both crossover and noncrossover products. Following nucleosome assembly, the chromatinized dHJ structures are preferentially dissolved by BTRR. These new Holliday junction substrates will provide a valuable resource for the mechanistic analyses of the way in which recombination intermediates are processed.
Arm locking performance with the new LISA design
Authors: Ghosh Sourath , Sanjuan Josep , Mueller Guido 
Published: April 2022

Abstract
The laser interferometer space antenna (LISA) is a future space-based gravitational wave detector designed to be sensitive to sources radiating in the low frequency regime (0.1 mHz to 1 Hz). LISA’s interferometer signals will be dominated by laser frequency noise which has to be suppressed by about seven orders of magnitude using an algorithm called time delay interferometry (TDI). Arm locking has been proposed to reduce the laser frequency noise by a few orders of magnitude to reduce the potential risks associated with TDI. In this paper, we present an updated performance model for arm locking for the new LISA mission using 2.5 Gm arm lengths, the currently assumed clock noise, spacecraft motion based on LISA Pathfinder data and shot noise. We also update the Doppler frequency pulling estimates during lock acquisition.
A stability result for the identification of a permeability parameter on Navier–Stokes equations
Authors: Aguayo Jorge , Osses Axel 
Published: April 2022

AbstractIn this work, we present a stability result for the inverse problem of recovering a smooth scalar permeability parameter given by the Brinkman’s law applied to the steady Navier–Stokes equations from local observations of the fluid velocity on a fixed domain. In comparison with (Choulliet al2013Appl. Anal.922127–43), we prove a logarithmic estimate under weaker assumptions, since our proof is based in a strategy that does not require pressure observations. This kind or result are useful for inverse problems in soft tissue elastography (see Honarvaret al2012Phys. Med. Biol.575909–27). Finally, we present some numerical tests that validate our theoretical results.
A multi-functional frequency selective polarization converter based on substrate integrated waveguide cavities
Authors: Ren Yan , Lin Hai , Tang Rongxin , Wu Yanjie , Zhou Rui , Xiong Jie 
Published: April 2022

Abstract
In this paper, a multi-functional frequency selective polarization converter (FSPC) based on the substrate integrated waveguide cavities (SIWC) is presented. The proposed structure is based on a circular shape SIWC with orthogonal rectangular slots on the top/bottom layer of each unit cell. The neighboring SIWC are connected to each other by metalized vias which formed a shared diamond shape cavity. Two cross shape slots serve as additional input and output channel for the shared SIW cavity. The novel design introduces more functions to the device. When the device acts as a frequency selective surface, it provide two transmission window around 8.52 and 13 GHz. It can also realize cross-polarization conversion between TM and TE polarized waves from 15.87 to 17.01 GHz as well as narrowband polarization conversion around 10.33 GHz. The working mechanism of proposed design has been explained through the analysis of the surface current distribution. In order to verify the performance of the design, a prototype was manufactured and measured, the simulated and measured results are highly consistent with each other.