bluuebunny/crossref_metadata_2025_split huggingface dataset:
The history of Islam in Indonesian politics of memory
Authors: Кирчанов Максим Валерьевич 
Published: August 2022

The article analyses the perception of the history of the Muslim community in the modern Indonesian politics of memory. For the first time in Belarusian historiography, the features of the historical politics or the politics of memory in modern Indonesia are considered. The novelty of the article lies in the integration of Indonesian issues into the contexts of modern interdisciplinary memorial studies. The key subjects of the politics of memory in Indonesia are determined in contexts of the revision of the history of political Islam in the second half of the 20th century. The activity of the media is considered as the main form of the revision of history, criticism of old historical narratives and the formation of a new memorial canon of the history of Indonesian Islam. Attempts to revise the history of Islam are analysed, including new interpretations of Muslim activists, who impact participated in the national movement. The author analyses the contradictions of historical politics in the context of integration of the history of Indonesian political Islam of the 20th century into the secular memorial canon. It is assumed that attempts to construct the history of political Islam in the modern collective Indonesian memory have a compromise character. The author shows how intellectuals assimilate the history of Islam, integrating it into the current memorial canon. It is noted that within the framework of the politics of memory, ideologically and politically controversial points related to the history of radical political Islam, which in the early model of national memory were marginalised and forgotten. Modern manipulations with historical memory are analysed as attempts to achieve a memorial compromise between secular intellectuals and representatives of the Muslim community.
Pemidanaan Double Track Sistem Terhadap Pelaku Tindak Pidana Korupsi
Authors: Saputra Ervin Pratama , Artadi Ibnu , Sanusi Sanusi 
Published: August 2022

Sistem pemidanaan double track system berupa pidana pokok dan pidana tindakan dapat diajtuhkan. Hakim terhadap pelaku tindak pidana korupsi yang termasuk dalam tindak pidana extra ordinary crime haruslah memiliki efek jera. Begitu pula dalam perkara Dinas PUPR kota Cirebon pada tahun anggaran 2017 terdapat pekerjaan peningkatan jalan Dr. Cipto Mangunkusumo dalam pekerajaan tersebut terdapat temuan kelebihan bayar menyangkut volume maupun kualitas yang tidak sesuai dengan ketentuan dalam kontrak, yang mengakibatkan indikasi kuat karena adanya kerugian keuangan Negara/daerah sebesar Rp. 2.334.021.032,47. Penelitian ini menggunakan penelitian yuridis normatif, dengan cara mengkaji dan mendeskripsikan dari bahan-bahan pustaka yang berupa literatur, perundang-undangan dan beberapa berita yang berkaitan dengan permasalahan yang akan dibahas, dalam hal ini adalah berkaitan dengan pemidanaan terhadap pelaku tindak pidana korupsi dalam putusan NO. 55 PIDSUS-TPK/2020/PN.BDG dan No. 10 TIPIKOR/2020/PT.BDG. Dalam Undang-Undang Pemberantasan Tindak Pidana Korupsi telah mengatur pidana pokok dan pidana tindakan, dalam hal ini pidana uang pengganti dalam kerugian keuangan Negara yang telah dinikmati terpidana. Tetapi dalam pemidanaan Tindak Pidana Korupsi, ada beberapa putusan hakim yang belum menerapkan double track system. Dasar pertimbangan hakim dalam menjatuhkan pidana harus melihat fakta-fakta dalam persidangan dan harus memperhatikan hal-hal yang meringankan dan memberatkan.
Finite element modeling for predicting sound insulation of fixed windows in a laboratory environment
Authors: Mimura Marie , Okuzono Takeshi , Sakagami Kimihiro 
Published: August 2022

This paper presents discussion of the prediction capability of three numerical models using finite element method for predicting the sound reduction index (SRI) of fixed windows having different dimensions in a laboratory environment. The three numerical models tested here only discretize the window part or windows part and the space around the windows to reduce the necessary computational cost for vibroacoustics simulations. An ideal diffused sound incidence condition is assumed for three models. Their predictability and numerical efficiency were examined over five fixed windows with different dimensions compared to measured SRIs. First, the accuracy of the simplest model in which the window part is only discretized with finite elements was examined. Acoustic radiation to the transmission field is computed using Rayleigh’s integral. Calculations were performed under two loss factor setups respectively using internal loss factors of each material and measured total loss factor of each window. The results were then compared with the measured values. Results revealed the effectiveness of using the measured total loss factor at frequencies around and above the coincidence frequencies. Subsequently, we tested the prediction accuracy of a numerical model that includes a niche existing in a laboratory environment. Also, hemispherical free fields around the window are discretized using fluid elements and infinite fluid elements. The results underscored the importance of including a niche in a numerical model used to predict sound reduction index below 1 kHz for smaller windows accurately. Nevertheless, this numerical model, including a niche, entails high computational costs. To enhance the prediction efficiency, we examined the applicability of a weak-coupling model that divides calculation procedures into three steps: (1) incidence field calculation to the window surface, (2) sound transmission calculation in fixed windows, and (3) sound radiation calculation from a window surface to a transmission field. Results revealed that the weak-coupling model produces almost identical results to those of a strong-coupling model, but with higher efficiency.
Performance of human papillomavirus E6/E7 mRNA assay for primary cervical cancer screening and triage: Population-based screening in China
Authors: Zhang Jing , Yang Di , Cui Xiaoli , Liu Guangcong , Cui Zhumei , Wang Chunyan , Piao Haozhe 
Published: August 2022

ObjectiveCervical cancer screening is very important in the prevention and treatment of cervical cancer. In China, the cervical screening strategy needs to be improved. To explore a suitable cervical screening strategy in China, we evaluated the performance of the human papillomavirus (HPV) E6/E7 mRNA (Aptima HPV (AHPV)) assay in primary screening and different triage strategies for women undergoing routine cervical screening.MethodsA total of 10,002 women aged 35 to 65 years of age were recruited in Liaoning Province and Qingdao City, China. Specimens were tested by liquid-based cytology (LBC) and the AHPV assay, and women who tested positive on any test were referred for colposcopy. Genotyping was performed on all high-risk HPV (HR-HPV)-positive samples. Test characteristics were calculated based on histological review.ResultsWe identified 109 women with high-grade squamous intraepithelial lesion or worse (HSIL+), including six with cervical cancer. The sensitivity of AHPV was clearly higher than that of LBC (92.7 [95% CI: 87.2, 97.2] vs. 67.9 [95% CI: 59.6, 76.1], p &lt; 0.001). The specificity of AHPV was 93.0 (95% CI: 92.5, 93.5), which was lower than that of LBC (95.2 [95% CI: 94.8, 95.6], p &lt; 0.001). There was no statistical difference between the positive predictive value of AHPV and LBC (13.5 [95% CI: 11.2, 16.2] vs. 14.3 [95% CI: 11.4, 17.6], p = 0.695). The difference of area under the curve (AUC) values between the AHPV test (0.928 [95% CI: 0.904, 0.953]) and LBC test (0.815 [95% CI: 0.771, 0.860]) in detecting HSIL+ was statistically significant (p &lt; 0.001). Finally, among the three triage strategies, both the sensitivity (73.4 [95% CI: 65.1, 81.7]) and AUC (0.851 [95% CI: 0.809, 0.892]) of AHPV genotyping with reflex LBC triage were the greatest.ConclusionIn summary, the AHPV assay is both specific and sensitive for detecting HSIL+ and may be suitable for use in primary cervical cancer screening in China. AHPV genotyping with reflex LBC triage may be a feasible triage strategy.
Nosocomial dissemination of hypervirulent Klebsiella pneumoniae with high-risk clones among children in Shanghai
Authors: Du Qingqing , Pan Fen , Wang Chun , Yu Fangyuan , Shi Yingying , Liu Wenxin , Li Zhi , He Ping , Han Dingding , Zhang Hong 
Published: August 2022

ObjectivesAlthough hypervirulent Klebsiella pneumoniae (hvKp) is an increasing public health problem, there remains limited epidemiological information regarding hvKp infections in children. Here, we conducted a clinical, molecular and phenotypic surveillance of hvKp strains in a pediatric population.MethodsNon-repetitive K. pneumoniae (Kp) strains consecutively collected during 2019-2020 were screened for hypervirulence genes (prmpA, prmpA2, iucA, iroB, and peg344) using PCR. Positive strains were further characterized by four phenotypic assays (string test, serum killing assay, siderophore production, Galleria mellonella lethality assay), followed by murine sepsis model to determine virulence in vitro and in vivo. Also, capsular types, sequence types, plasmid replicon types, antimicrobial resistance determinants and susceptibility were analyzed.ResultsA total of 352 isolates were collected, wherein 83 (23.6%) were hypervirulence genes-positive Kp (hgKp). A significant increase in KPC-2-producing KL47-ST11 among hgKp strains was observed, from 5.3% (1/19) in 2019 to 67.6% (25/37) in 2020 (P&lt;.0001), suggesting the potential dissemination of the hybrid virulence and carbapenem-resistance encoding plasmid among children. Further, hgKp isolates were classified into hvKp (n = 27) and hgKp-low virulence (hgKp-Lv) (n = 56) based on virulence phenotypic assays. In hvKp, diverse genetic clones were observed and K1-ST23 or K2-ST25 strains with sensitivity to multiple antibiotics were prevalent (25.9%, 7/27). Compared with hgKp-Lv, hvKp infection had a higher propensity to involve severe pneumonia (22.2% vs. 12.5%) in elder children and significant higher mortality in mice (P = 0.0086). Additionally, either hvKp or hgKp-Lv infections were mostly healthcare-associated and hospital-acquired (74.1% vs. 91.9%).ConclusionsThese data suggest that K1-ST23 and K2-ST25 are high-risk clones of hvKp, and the genetic convergence of virulence and carbapenem-resistance is increasing among children. Control measures are needed to prevent the dissemination in clinical settings.
Response of planktonic foraminifera to seasonal and interannual hydrographic changes: Sediment trap record from the northern South China Sea
Authors: Lin Hui-Ling , Lui Hon-Kit , Lin Tai-Chun , Wang You-Lin 
Published: August 2022

Foraminifera play an important role in the organic and inorganic carbon pumps of the ocean. Understanding their responses in seasonal and interannual time scales to the climate and seawater chemistry changes is important for studying carbon cycles and paleoclimatology. This study examined about 5.1-year continuous mass fluxes in 2013/9-2019/8 and 1.8-year planktonic foraminiferal shell fluxes in 2016/8-2019/8 census from ten and four sets of sediment traps, respectively, moored at the South East Asia Time-series Study (SEATS) site in the northern South China Sea (SCS), the world’s largest marginal sea. A total of four sets of sediment trap mooring with 11 common species were identified, spanning from August 2016 to August 2019 with 8-day and 16-day collecting periods, which provided access to evaluate the impact of the prevailing monsoon system and interannual climatic conditions. Our results show that the winter monsoon enhances the nutrient inventories in the euphotic zone, supporting the productivity and the mass and shell fluxes. In addition to seasonal cycles, the variation of chlorophyll-a concentration in the SCS shows a strong response to wind speed under the influence of El Niño–Southern Oscillation (ENSO). The reduction in wind speed and the intensification of Kuroshio intrusion during the ENSO warm phases reduces the productivity and mass and shell fluxes, and vice versa in the case of the ENSO cold phases. The imprint of an ENSO cold phase (La Niña event) in 2017 was signified by 2–3-fold higher values than the 3-year average of total mass and foraminiferal shell fluxes. Instead of the common dominance of Trilobatus sacculifer and Globigerinoides ruber among species composition, Neogloboquadrina dutertrei was the predominant species comprising over 40%–60% of total shells greater than 212 μm. Furthermore, the interval with an elevated abundance of N. dutertrei lasted throughout January 2018 (four collecting intervals). Foraminifera shell fluxes were the lowest during warm months (March-August) in 2019, which was coeval with the increase in proportions of Orbulina universa and Globigerinella calida. The unusual species composition might signify a weak ENSO warm phase (A weak El Niño event) between September 2018 and August 2019.
Spatiotemporal variations in runoff and runoff components in response to climate change in a glacierized subbasin of the Upper Indus Basin, Pakistan
Authors: Adnan Muhammad , Liu Shiyin , Saifullah Muhammad , Iqbal Mudassar , Ali Ayaz Fateh , Mukhtar Muhammad Ahsan 
Published: August 2022

Change in seasonal snowfall and glaciers ablation control year-to-year variations in streamflows of the Upper Indus Basin (UIB) and hence ultimately impacts the water availability in downstream areas of UIB. This situation calls for an urgent response to study the long-term variations in runoff components in response to climate change. The current study investigates the spatiotemporal variations in runoff and runoff components in response to climate change to the streamflows of the Gilgit River from 1981 to 2020 by using the University of British Columbia Watershed Model (UBC WM). Three statistical indices such as the Nash–Sutcliffe efficiency (NSE), the coefficient of determination (R2), and the correlation coefficient (CC) were used to evaluate the performance of UBC WM in simulating the streamflows against observed streamflows. According to statistical indices, the UBC WM performed fairly well during both calibration (1981–2000: R2 = 0.90, NSE = 0.87, and CC = 0.95) and validation periods (2001–2015: R2 = 0.86, NSE = 0.83, and CC = 0.92). Trend analysis revealed a significant increase in all runoff components with large interannual variations in their relative contributions to streamflows from 1981 to 2020. From 1981 to 2020, the average relative contribution of snowmelt, glacier melt, rainfall-runoff, and baseflow was estimated to be 25%, 46%, 5%, and 24%, respectively to the streamflows of the Gilgit River. Seasonal analysis showed that about 86% of total runoff was contributed to the Gilgit River during the summer season (April–September) while only 14% in the winter season (October–March). Further analysis of runoff at a spatial scale revealed that approximately 76% of the total runoff of Gilgit River is generated between elevations from 3680 to 5348 m while 19% of total runoff is generated at an elevation &lt;3680 m and only 5% at an elevation &gt;5348 m. Moreover, it was observed that groundwater contribution from soil lower zone (i.e., 76%) to streamflows was found greater than soil upper zone (i.e., 24%). The outcomes of this study will help the water resource managers and hydrologists to manage the water resources in downstream areas of the UIB for local consumption, industrial use, and agriculture.
Classification of pyroptosis patterns and construction of a novel prognostic model for prostate cancer based on bulk and single-cell RNA sequencing
Authors: Fu Jianhan , Li Guoqiang , Luo Ruixiang , Lu Zhijie , Wang Yinhuai 
Published: August 2022

BackgroundEmerging evidence suggests an important role for pyroptosis in tumorigenesis and recurrence, but it remains to be elucidated in prostate cancer (PCa). Considering the low accuracy of common clinical predictors of PCa recurrence, we aimed to develop a novel pyroptosis-related signature to predict the prognosis of PCa patients based on integrative analyses of bulk and single-cell RNA sequencing (RNA-seq) profiling.MethodsThe RNA-seq data of PCa patients was downloaded from several online databases. PCa patients were stratified into two Classes by unsupervised clustering. A novel signature was constructed by Cox and the Least Absolute Shrinkage and Selection Operator (LASSO) regression. The Kaplan-Meier curve was employed to evaluate the prognostic value of this signature and the single sample Gene Set Enrichment Analysis (ssGSEA) algorithm was used to analysis tumor-infiltrating immune cells. At single-cell level, we also classified the malignant cells into two Classes and constructed cell developmental trajectories and cell-cell interaction networks. Furthermore, RT-qPCR and immunofluorescence were used to validate the expression of core pyroptosis-related genes.ResultsTwelve prognostic pyroptosis-related genes were identified and used to classify PCa patients into two prognostic Classes. We constructed a signature that identified PCa patients with different risks of recurrence and the risk score was proven to be an independent predictor of the recurrence free survival (RFS). Patients in the high-risk group had a significantly lower RFS (P&lt;0.001). The expression of various immune cells differed between the two Classes. At the single-cell level, we classified the malignant cells into two Classes and described the heterogeneity. In addition, we observed that malignant cells may shift from Class1 to Class2 and thus have a worse prognosis.ConclusionWe have constructed a robust pyroptosis-related signature to predict the RFS of PCa patients and described the heterogeneity of prostate cancer cells in terms of pyroptosis.
Triglyceride-glucose index and stroke recurrence in elderly patients with ischemic stroke
Authors: Wang Fang , Wang Jinjing , Han Yunfei , Shi Xuan , Xu Xiaohui , Hou Chao , Gao Jie , Zhu Shuanggen , Liu Xinfeng 
Published: August 2022

Background and purposeThis study aimed to explore the association between triglyceride–glucose (TyG) index and stroke recurrence in elderly patients with ischemic stroke in China.MethodsWe enrolled ischemic stroke patients aged ≥ 65 years from the Nanjing Stroke Registry Program. The primary endpoint was defined as recurrent stroke within one year after the index stroke. We used multivariable Cox proportional hazards regression models to investigate the association between TyG index and stroke recurrence. We assessed the discriminative ability of TyG index with the receiver operative characteristic and the area under the curve.ResultsA total of 955 patients (median age, 70.0 [67.0, 75.0]; male sex, 67.2%) from the Nanjing Stroke Registry Program were enrolled. During one year follow-up, 97 (10.2%) elderly patients experienced stroke recurrence. In multivariable analyses, the association between TyG index and stroke recurrence remained significant after adjusting for confounders (quartile 4 versus quartile 1; hazard ratio, 2.073, 95% confidence interval, 1.158-3.711; P = 0.014). The restricted cubic spline showed an increasing trend for TyG index and stroke recurrence (P for non-linearity = 0.072). The area under the curve to predict stroke recurrence with TyG index was 0.719 (95% confidence interval, 0.666-0.772). Besides, TyG index slightly improved the prediction for stroke recurrence.ConclusionElevated TyG index was associated with stroke recurrence in elderly patients with ischemic stroke. Further studies are warranted to assess the role of TyG index in the development of stroke recurrence in the elderly.
Intrauterine interventions for women with two or more implantation failures: A systematic review and network meta-analysis
Authors: Jin Xin Hang , Li Yang , Li Dan 
Published: August 2022

ObjectiveTo compare the effectiveness of different intrauterine interventions for women with two or more unexplained implantation failures.DesignA systematic review and network meta-analysis of randomized controlled trials (RCTs).Patient(s)Women with two or more implantation failures undergoing fresh or frozen embryo transfer (ET).Intervention(s)An electronic search of the following databases: Pubmed, Cochrane Central Register of Controlled Trials (CENTRAL), and Embase.Main Outcome Measure(s)Clinical pregnancy, live birth/ongoing pregnancy, and miscarriage.Result(s)We included 21 RCTs(3079 women) in the network meta-analysis. The network meta-analysis showed that compared with control treatment, platelet-rich plasma(PRP), peripheral blood mononuclear cells (PBMC), granulocyte colony-stimulating factor(G-CSF), human chorionic gonadotropin(HCG), and endometrial scratch(ES) significantly increased clinical pregnancy(OR 3.78, 95% CI 2.72 to 5.25; 2.79, 95% CI 1.75 to 4.45; 1.93, 95% CI 1.37 to 2.72; 1.80, 95% CI 1.18 to 2.72; 1.75, 95% CI 1.29 to 2.36, respectively). PRP ranked the highest in improving clinical pregnancy, followed by PBMC, G-CSF, HCG, and ES. Compared with control treatment, PRP, PBMC, and ES significantly increased live birth/ongoing pregnancy (OR 5.96, 95% CI 3.38 to 10.52; OR 2.55, 95% CI 1.27 to 5.11; OR 1.70, 95% CI 1.07 to 2.69, respectively). PRP ranked the highest in improving live birth/ongoing pregnancy, followed by PBMC, and ES.Conclusion(s)PRP is the most effective intrauterine intervention in improving pregnancy outcome in women with two or more implantation failures.
Outcome of giant pituitary tumors requiring surgery
Authors: Gaillard Stephan , Adeniran Sosthène , Villa Chiara , Jouinot Anne , Raffin-Sanson Marie-Laure , Feuvret Loic , Verrelle Pierre , Bonnet Fidéline , Dohan Anthony , Bertherat Jérôme , Assié Guillaume , Baussart Bertrand 
Published: August 2022

ObjectiveThe management of giant pituitary tumors is complex, with few publications and recommendations. Consequently, patient’s care mainly relies on clinical experience. We report here a first large series of patients with giant pituitary tumors managed by a multidisciplinary expert team, focusing on treatments and outcome.MethodsA retrospective cohort study was conducted. Giant pituitary tumors were defined by a main diameter &gt; 40mm. Macroprolactinomas sensitive to dopamine agonists were excluded. All patients were operated by a single neurosurgical team. After surgery, multimodal management was proposed, including hormone replacement, radiotherapy and anti-tumor medical therapies. Outcome was modeled using Kaplan-Meyer representation. A logistic regression model was built to identify the risk factors associated with surgical complications.Results63 consecutive patients presented a giant adenoma, most often with visual defects. Patients were operated once, twice or three times in 59%, 40% and 1% of cases respectively, mainly through endoscopic endonasal approach. Giant adenomas included gonadotroph, corticotroph, somatotroph, lactotroph and mixed GH-PRL subtypes in 67%, 14%, 11%, 6% and 2% of patients respectively. Vision improved in 89% of patients with prior visual defects. Severe surgical complications occurred in 11% of patients, mainly for tumors &gt; 50 mm requiring microscopic transcranial approach. Additional radiotherapy was needed for 29% of patients, 3 to 56 months after first surgery. For 6% of patients, Temozolomide treatment was required, 19 to 66 months after first surgery.ConclusionsGiant pituitary tumors require multimodal management, with a central role of surgery. Most often, tumor control can be achieved by expert multidisciplinary teams.