bluuebunny/crossref_metadata_2025_split huggingface dataset:
Irreducible Phalangeal Fractures Due to Incarceration into the Extensor Tendon Apparatus – A Report of Two Patients
Authors: KRISHNA Sathya Vamsi , GIRISH Akshay Bailahalli , REDAPPA Jainath , HOSAHALLI Chandrashekar 
Published: February 2022

Irreducible phalangeal fractures are uncommon, and if neglected can cause fracture non-union or functional deficits of the affected digit. We present two patients with irreducible phalangeal fractures – one in a child with a juxta-epiphyseal middle phalanx fracture incarcerated into the triangular ligament of the extensor apparatus and another in an adult following incarceration of a fractured proximal phalanx into the common intrinsic tendon on the radial side. Both required open reduction to extricate the incarcerated fracture ends, achieving good union and excellent functional outcomes. Level of Evidence: Level V (Therapeutic)
Ouvido-voz: uma máquina
Authors: Penha Gustavo Rodrigues 
Published: February 2022

Este artigo aborda a conexão entre ouvido e voz na construção de uma máquina perceptiva, selecionadora e preensora de linhas expressivas sonoras captadas auditivamente. Trata-se de uma etapa determinante no processo de audição, em que o aparelho vocal é acionado quando um sinal perceptivo se produz no ouvido, que é assim agitado ao se deparar com uma excitação material sonora exterior. Tal acionamento do aparelho fonador se dá instantaneamente à agitação do sinal perceptivo, funcionando de maneira complementar ao ouvido. Através de um cruzamento bibliográfico atento a alianças conceituais possíveis em uma ampla rede de textos, buscou-se conectar e colocar em ressonância autores literários, musicais e filosóficos que trataram direta ou indiretamente esse objeto de estudo, com o intuito de clarear alguns aspectos implicados na operação contínua de uma máquina ouvido-voz funcionando em diferentes modos de atividades perceptivas e criativas.
What is Radical?
Authors: Alberro Alexander , Bhabha Homi , Castillo Alejandra , Chukhrov Keti , Demos T. J. , Eleison Keyna , Emmelhainz Irmgard , English Darby , Flores Patrick , González Jennifer A. , Groys Boris , Holert Tom , Huyssen Andreas , Jones Amelia , Joselit David , Kee Joan , Mirzoeff Nicholas , Osborne Peter , Roberts John , Shaked Nizan , Smith Terry , Stiles Kristine , Tiampo Ming , Wagner Anne M. 
Published: February 2022

Abstract
What does it mean to think and act radically, and how does this relate to forms of radicalism connected to earlier moments, for example, in the 20th century? What can be the role of radical art and scholarship under the conditions of late capitalism? More generally, how can art and artists serve the ongoing struggle for social justice and the agendas of emancipatory social change? Finally, what kinds of art criticism and art historical scholarship are necessary to address the great challenges of our uncertain future?
The Pedagogy of Evangelism: Moving from a Didactic to a Conversational Model of Evangelism
Authors: Butler James 
Published: February 2022

Abstract
This paper argues that while evangelicalism has sought to maintain the importance of communicating a normative understanding of faith, it has done so primarily through a didactic understanding of evangelism. This has made it difficult to integrate informal and non-verbal expressions into an account of evangelism and, I argue, has contributed to evangelicalism’s problems of understanding the relationship between evangelism and social action. By turning to lived experience, and the ‘theology in four voices’ framework from theological action research, I suggest a conversational model of evangelism which enables a move away from a didactic model without losing a commitment to communicating a normative understanding of Christian faith. This model relates more clearly to the lived experience of participants in my research and enables a more integrated understanding of evangelism, which places greater value on the ordinary and everyday expression of faith.
Investigating Historical Abuses
Authors: Balk Yannick , Frerks Georg , de Graaf Beatrice 
Published: February 2022

Abstract
This article investigates the phenomenon and practice of intercountry adoption from a historical perspective by using applied history methods. In particular, we employed the method of historicizing current concerns, such as the notion of abuses, and contextualizing them in history. With these methods, we contributed to the Dutch governmental assessment and evaluation of intercountry adoption, indicating that our findings (as laid down in the official report) need to be translated into revised governmental policies. In this paper, we describe how we applied our historicizing methods to intercountry adoption abuses by providing a narrative and genealogy of the topic. We also discuss the pitfalls and merits of conducting historical research into practices that are now considered immoral or unjust, but were long standard practice after intercountry adoption started in the Netherlands. In this way, we also contribute to the ongoing discussion on doing historical research in highly politicized contexts, where the danger of contributing to the ‘blame game’ often lies in wait.
Clinical Use of an Electronic Pre-Visit Questionnaire Soliciting Patient Visit Goals and Interim History: A Retrospective Comparison Between Safety-net and Non-Safety-net Clinics
Authors: Shucard Hannah , Muller Emily , Johnson Joslyn , Walker Jan , Elmore Joann G. , Payne Thomas H. , Berman Jacob , Jackson Sara L. 
Published: February 2022

Introduction/Objectives We examined an initial step towards co-generation of clinic notes by inviting patients to complete a pre-visit questionnaire that could be inserted into clinic notes by providers and describe the experience in a safety-net and non-safety-net clinic. Methods We sent an electronic pre-visit questionnaire on visit goals and interim history to patients at a safety-net clinic and a non-safety-net clinic before clinic visits. We compared questionnaire utilization between clinics during a one-year period and performed a chart review of a sample of patients to examine demographics, content and usage of patient responses to the questionnaire. Results While use was low in both clinics, it was lower in the safety-net clinic (3%) compared to the non-safety-net clinic (10%). We reviewed a sample of respondents and found they were more likely to be White compared to the overall clinic populations ( p < 0.05). There were no statistically significant differences in patient-typed notes (word count and number of visit goals) between the safety-net and non-safety-net samples however, patients at the safety-net clinic were less likely to have all of their goals addressed within the PCP documentation, compared to the non-safety-net clinic. Conclusions Given potential benefits of this questionnaire as a communication tool, addressing barriers to use of technology among vulnerable patients is needed, including access to devices and internet, and support from caregivers or culturally concordant peer navigators.
Inhibition of LDHA to induce eEF2 release enhances thrombocytopoiesis
Authors: Chen Qidi , Xin Min , Wang Lingjun , Li Lin , Shen Yingzhi , Geng Yan , Jiang Haojie , Wang Yang , Zhang Lin , Xu Yanyan , Hou Yu , Liu Junling , Fan Xuemei 
Published: February 2022

Abstract
Translation is essential for megakaryocyte (MK) maturation and platelet production. However, how the translational pathways are regulated in this process remains unknown. In this study, we found that MK/platelet–specific lactate dehydrogenase A (LdhA) knockout mice exhibited an increased number of platelets with remarkably accelerated MK maturation and proplatelet formation. Interestingly, the role of LDHA in MK maturation and platelet formation did not depend on lactate content, which was the major product of LDHA. Mechanism studies revealed that LDHA interacted with eukaryotic elongation factor 2 (eEF2) in the cytoplasm, controlling the participation of eEF2 in translation at the ribosome. Furthermore, the interaction of LDHA and eEF2 was dependent on nicotinamide adenine dinucleotide (NADH), a coenzyme of LDHA. NADH-competitive inhibitors of LDHA could release eEF2 from the LDHA pool, upregulate translation, and enhance MK maturation in vitro. Among LDHA inhibitors, stiripentol significantly promoted the production of platelets in vivo under a physiological state and in the immune thrombocytopenia model. Moreover, stiripentol could promote platelet production from human cord blood mononuclear cell–derived MKs and also have a superposed effect with romiplostim. In short, this study shows a novel nonclassical function of LDHA in translation that may serve as a potential target for thrombocytopenia therapy.
Seismic history of western Anatolia during the last 16 kyr determined by cosmogenic 36Cl dating
Authors: Mozafari Nasim , Özkaymak Çağlar , Sümer Ökmen , Tikhomirov Dmitry , Uzel Bora , Yeşilyurt Serdar , Ivy-Ochs Susan , Vockenhuber Christof , Sözbilir Hasan , Akçar Naki 
Published: February 2022

AbstractWestern Anatolia is one of the most seismically active regions worldwide. To date, the paleoseismic history of many major faults, in terms of recurrence intervals of destructive earthquakes, their magnitude, displacement, and slip rates is poorly understood. Regional crustal extension has produced major horst-graben systems bounded by kilometer-scale normal faults locally in carbonates, along which vertical crustal displacements occurred. In this study, we explore the seismic history of western Anatolia using36Cl exposure dating through study of well-preserved carbonate normal fault scarps. To accomplish this,36Cl concentrations in 214 samples from fault plane transects on the Rahmiye and Ören fault scarps were measured and compared with existing36Cl measurements of 370 samples on five fault scraps in western Anatolia. At least 20 seismic events have been reconstructed over the past 16 kyr. The age correlation of the seismic events implies four phases of high seismic activity in western Anatolia, at around 2, 4, 6, and 8 ka. Slips are modeled ranging between 0.6 to 4.2 m per seismic event, but are probably the result of clustered earthquakes of maximum magnitude 6.5 to 7.1. While the average slip rates have values of 0.3 to 1.9 mm/yr, incremental slip rates of the faults range greater than 0.1 to 2.2 mm/yr, showing more activity mostly through late Holocene. Our finding reveals high capability of cosmogenic36Cl dating to explore seismic behavior of active faults beyond the existing earthquake records.
Assessment of potential human health risks in aquatic products based on the heavy metal hazard decision tree
Authors: Ku Hao-Hsiang , Lin Pinpin , Ling Min-Pei 
Published: February 2022

Abstract
Background
Naturally existing and human-produced heavy metals are released into the environment and cannot be completely decomposed by microorganisms, but they continue to accumulate in water and sediments, causing organisms to be exposed to heavy metals.

Results
This study designs and proposes heavy metal hazard decision trees for aquatic products, which are divided into seven categories including pelagic fishes, inshore fishes, other fishes, crustaceans, shellfish, cephalopods, and algae. Based on these classifications, representative fresh and processed seafood products are at the root of the heavy metal hazard decision trees. This study uses 2,107 cases of eating 556 cooked fresh or processed seafood product samples. The constructions of the proposed decision trees consist of 12 heavy metals, which include inorganic arsenic (iAs), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), manganese (Mn), nickel (Ni), lead (Pb), strontium (Sr), thallium (Tl), and zinc (Zn). The heavy metal concentrations in cooked fresh and processed seafood product samples are subjected to a food safety risk assessment.

Conclusions
The results indicate the relationships among the seven categories of aquatic products, the relationships among 12 heavy metals in aquatic products, and the relationships among potential human health risks. Finally, the proposed heavy metal hazard decision trees for aquatic products can be used as a reference model for researchers and engineers.
Echocardiographic study of myocardial work in patients with type 2 diabetes mellitus
Authors: Liao Lisi , Shi Bobo , Ding Zhimin , Chen Lixin , Dong Fajin , Li Jian , Zhong Yulin , Xu Jinfeng 
Published: February 2022

Abstract
Background
A noninvasive left ventricular (LV) pressure-strain loop (PSL) provides a new method to quantify myocardial work (MW) by combining global longitudinal strain (GLS) and LV pressure, which exerts potential advantages over traditional GLS. We studied the LV PSL and MW in patients with type 2 diabetes mellitus (T2DM).

Methods
This cross-sectional study included 201 subjects (54 healthy controls and 147 T2DM patients) who underwent complete two-dimensional echocardiography (2DE), including 2D speckle-tracking echocardiography (STE), as well as brachial artery pulse pressure measurement. The PSL was used to determine the global myocardial work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE) of all study participants. The association between T2DM and LV function was evaluated according to these MW indices.

Results
The GLS was significantly lower in the T2DM group than in the control group (P < 0.001), indicating that the LV myocardium had been damaged, although the LV ejection fraction (LVEF) was still normal. The GWI and GWE were decreased (P = 0.022) and the GWW was increased (P < 0.001) in diabetic patients compared with controls, but the GCW was comparable in the two groups (P = 0.160). In all diabetic patients, age, body mass index, systolic blood pressure, smoking history, and LVEF were correlated with GWI, GWW and GWE.

Conclusions
The use of LV PSL is a novel noninvasive technique that could help to depict the relationship between LV myocardial damage and MW in patients with T2DM.
Risk prediction in pulmonary hypertension due to chronic heart failure: incremental prognostic value of pulmonary hemodynamics
Authors: Quan Ruilin , Huang Shian , Pang Lingpin , Shen Jieyan , Wu Weifeng , Tang Fangming , Zhu Xiulong , Su Weiqing , Sun Jingzhi , Yu Zaixin , Wang Lemin , Zhu Xianyang , Xiong Changming , He Jianguo 
Published: February 2022

Abstract
Background
There is no generally accepted comprehensive risk prediction model cooperating risk factors associated with heart failure and pulmonary hemodynamics for patients with pulmonary hypertension due to left heart disease (PH-LHD). We aimed to explore outcome correlates and evaluate incremental prognostic value of pulmonary hemodynamics for risk prediction in PH-LHD.

Methods
Consecutive patients with chronic heart failure undergoing right heart catheterization were prospectively enrolled. The primary endpoint was all-cause mortality. Individual variable selection was performed by machine learning methods. Cox proportional hazards models were conducted to identify the association between variables and mortality. Incremental value of hemodynamics was evaluated based on the Seattle heart failure model (SHFM) and Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) scores.

Results
A total of 276 PH-LHD patients were enrolled, with a median follow-up time of 34.7 months. By L1-penalized regression model and random forest approach, diastolic pressure gradient (DPG) and mixed venous oxygen saturation (SvO2) were the hemodynamic predictors most strongly associated with mortality (coefficient: 0.0255 and -0.0176, respectively), with consistent significance after adjusted for SHFM [DPG: HR 1.067, 95% CI 1.024–1.113, P = 0.022; SvO2: HR 0.969, 95% CI 0.953–0.985, P = 0.002] or MAGGIC (DPG: HR 1.069, 95% CI 1.026–1.114, P = 0.011; SvO2: HR 0.970, 95% CI 0.954–0.986, P = 0.004) scores. The inclusion of DPG and SvO2 improved risk prediction compared with using SHFM [net classification improvement (NRI): 0.468 (0.161–0.752); integrated discriminatory index (IDI): 0.092 (0.035–0.171); likelihood ratio test: P < 0.001] or MAGGIC [NRI: 0.298 (0.106–0.615); IDI: 0.084 (0.033–0.151); likelihood ratio: P < 0.001] scores alone.

Conclusion
In PH-LHD, pulmonary hemodynamics can provide incremental prognostic value for risk prediction.
Clinical trial registration: NCT02164526 at https://clinicaltrials.gov.
Daily associations between affect and cognitive performance in older adults with depression and cognitive impairment: a series of seven single-subject studies in the Netherlands
Authors: Tieks Alieke , Oude Voshaar Richard C. , Zuidersma Marij 
Published: February 2022

Abstract
Background
Comorbidity between depression and cognitive impairment is common in older adults, increases the disease burden disproportionally, and leads to diagnostic uncertainty. Insight into individual daily associations between affect and cognitive performance may help in personalizing diagnosis and treatment decisions. Our objective was to get insight into the daily associations between affect and cognitive performance within individual older adults.

Methods
In this single-subject study seven older adults with both depression and cognitive impairment filled in electronic diaries daily for 62-93 consecutive days evaluating positive affect (PA), negative affect (NA), working memory (WM) and visual learning (VL). Time-series analyses using vector autoregressive modelling, Granger causality tests and cumulative orthogonalized impulse response function analyses were performed for each individual separately.

Results
In one patient higher NA was associated with better WM the next day. For another patient days with higher NA and lower PA were days with worse WM. For a third patient better VL was associated with lower NA and higher PA the next day. No associations were found for four patients.

Conclusions
These results highlight heterogeneity in the daily associations between affect and cognitive performance and stress the relevance of single-subject studies. These studies may be an important step towards personalized diagnosis and treatment in old age psychiatry.
Exploring the value of Mycobacterium tuberculosis modified lipoprotein as a potential biomarker for TB detection in children
Authors: Yang Xinxin , Wipperman Matthew F. , Nachman Sharon , Sampson Nicole S. 
Published: February 2022

Abstract
Background
Current TB diagnostic methods available have been developed for adults and development efforts have neglected the differences in disease and sampling that occur between adults and children. Diagnostic challenges are even greater in HIV co-infected children and infants.

Methods and results
We established a sandwich ELISA assay to detect Mycobacterium tuberculosis modified lipoprotein (TLP) ex vivo in plasma. The study population contains plasma samples from 21 patients with active TB and 24 control samples with no TB, collected in the International Maternal Pediatric Adolescent AIDS Clinical Trails (IMPAACT) P1041 study. Retrospective analysis was performed and the results demonstrate that the median plasma levels of TLP in control subjects are 2.7 fold higher than the median plasma values in active TB subjects (p < 0.001).

Conclusions
Plasma levels of TLP are elevated with active TB disease in HIV positive subjects and deserves further exploration as an indicator for TB detection in children.
Artificial intelligence stenosis diagnosis in coronary CTA: effect on the performance and consistency of readers with less cardiovascular experience
Authors: Han Xianjun , Luo Nan , Xu Lixue , Cao Jiaxin , Guo Ning , He Yi , Hong Min , Jia Xibin , Wang Zhenchang , Yang Zhenghan 
Published: February 2022

AbstractBackgroundTo investigate the influence of artificial intelligence (AI) based on deep learning on the diagnostic performance and consistency of inexperienced cardiovascular radiologists.MethodsWe enrolled 196 patents who had undergone both coronary computed tomography angiography (CCTA) and invasive coronary angiography (ICA) within 6 months. Four readers with less cardiovascular experience (Reader 1–Reader 4) and two cardiovascular radiologists (level II, Reader 5 and Reader 6) evaluated all images for ≥ 50% coronary artery stenosis, with ICA as the gold standard. Reader 3 and Reader 4 interpreted with AI system assistance, and the other four readers interpreted without the AI system. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy (area under the receiver operating characteristic curve (AUC)) of the six readers were calculated at the patient and vessel levels. Additionally, we evaluated the interobserver consistency between Reader 1 and Reader 2, Reader 3 and Reader 4, and Reader 5 and Reader 6.ResultsThe AI system had 94% and 78% sensitivity at the patient and vessel levels, respectively, which were higher than that of Reader 5 and Reader 6. AI-assisted Reader 3 and Reader 4 had higher sensitivity (range + 7.2–+ 16.6% and + 5.9–+ 16.1%, respectively) and NPVs (range + 3.7–+ 13.4% and + 2.7–+ 4.2%, respectively) than Reader 1 and Reader 2 without AI. Good interobserver consistency was found between Reader 3 and Reader 4 in interpreting ≥ 50% stenosis (Kappa value = 0.75 and 0.80 at the patient and vessel levels, respectively). Only Reader 1 and Reader 2 showed poor interobserver consistency (Kappa value = 0.25 and 0.37). Reader 5 and Reader 6 showed moderate agreement (Kappa value = 0.55 and 0.61).ConclusionsOur study showed that using AI could effectively increase the sensitivity of inexperienced readers and significantly improve the consistency of coronary stenosis diagnosis via CCTA.Trial registrationClinical trial registration number: ChiCTR1900021867. Name of registry: Diagnostic performance of artificial intelligence-assisted coronary computed tomography angiography for the assessment of coronary atherosclerotic stenosis.
Hydro-dispersion of subincisional cortex
Authors: Miyoshi Teruyuki , Yoshida Hironori , Shimowake Takahiro , Oshika Tetsuro 
Published: February 2022

Abstract
Background
A simple technique to facilitate removal of subincisional cortex in cataract surgery is presented.

Methods
A disposable 27-gauge blunt needle attached to a 5.0-ml syringe containing balanced salt solution (BSS) is introduced through the side port incision into the anterior chamber. The tip of the needle is directed toward the capsule fornix beneath the incision site, and BSS is flushed to disperse the remaining cortex. Thereafter, the coaxial irrigation/aspiration device is used to remove the loosened cortex.

Results
This technique was used in 60 eyes of 60 patients with difficulty of removing cortical remnant in the subincisional space. Subincisional cortical material was successfully removed in 93.3% (56/60 eyes). There were no intraoperative and postoperative complications related to this procedure.

Conclusions
The hydro-dispersion technique is a simple and safe approach to remove the subincisional cortical material that is difficult to manage with the standard coaxial irrigation/aspiration device.