bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differentiation of intracranial Rosai‐Dorfman histiocytosis from meningioma using MR perfusion
Authors: Bueno Hugo F. , Agarwalla Pankaj K. , Chundury Anupama , Baisre de Leon Ada , Mirani Neena , Nimchinsky Esther A. 
Published: April 2022

AbstractIntracranial Rosai‐Dorfman disease may be indistinguishable from meningioma. This distinction is essential, as they are treated very differently. We present two cases where perfusion imaging helped make this distinction, allowing one to be treated successfully without craniotomy. Perfusion imaging may be a powerful adjunct in cases where RDD mimics meningioma.
Intimate partner violence with vaginal insertion of a partial chili pod (Capsicum annuum): A case report
Authors: Dorji Namkha , Tshering Sangay , Wangmo Dechen , Dorji Thinley 
Published: April 2022

AbstractA case of intimate partner violence (IPV) with vaginal insertion of an irritant foreign body, chili pod of Capsicum annum, in a 36‐year‐old woman. She presented with severe burning sensation in the lower abdomen and vulva. This highlights the unique role of gynecologists in the recognition and treatment of IPV.
Cystic adventitial disease of the popliteal artery with unusual spontaneous regression: A case report with literature review
Authors: Affes Meriem , Chaabouni Mohamed , Attia Monia , Jaber Chaker , Baccouche Ines , Kchaou Salma , Nèji Henda , Hantous‐Zannad Saoussen 
Published: April 2022

AbstractThis report highlights the case of cystic adventitial disease of the left popliteal artery in a 45‐year‐old male patient. Imaging modalities confirmed the diagnosis and high resolution MRI found a cystic connection to the adjacent knee joint. The evolution was unusual with spontaneous regression of the symptoms.
Insight into the Influence of WOx‐Support Interaction over Pt/W/SiZr Catalysts on 1,3‐Propanediol Synthesis from Glycerol
Authors: Zhao Junxiu , Hou Bo , Guo Heqin , Jia Litao , Niu Pengyu , Chen Congbiao , Xi Hongjuan , Li Debao , Zhang Jianli 
Published: April 2022

AbstractFor Pt‐WOx‐based catalysts, researchers pay much attention to study the influence of Pt‐WOx interaction on glycerol hydrogenolysis, ignoring the interaction between WOx and support. Herein, four Pt/W/SiZr‐T catalysts with different surface hydroxyl groups on support are prepared and characterized. The results show that bibridged (OHII) and tribridged hydroxyl groups (OHIII) on SiZr‐T supports could react with WOx species through forming Zr−O−W bands and retard the agglomeration of WOx species. The highly dispersed WOx species and Zr−O−W bands are the origination of inherent and in‐situ generated Brønsted acid, which are beneficial for 1,3‐propanediol synthesis. As a result, Pt/W/SiZr‐70 exhibits outstanding performance due to abundant OHII and OHIII on SiZr‐70. The initial space time yield of 1,3‐propanediol on Pt/W/SiZr‐70 reaches 2.280 g1,3‐PDO ⋅ gcat−1 ⋅ h−1, the highest among reported results. This r esearch reveals the role of WOx‐support interaction on glycerol hydrogenolysis and provides a new direction to design Pt‐WOx‐based catalysts for selective hydrogenation reactions.
Comparison of Carbon Nanomaterials for Simultaneous Detection of Neurotransmitters in the Presence of Interfering Species
Authors: Mazurkiewicz Wojciech , Małolepszy Artur , Witkowska Nery Emilia 
Published: April 2022

AbstractThe main hurdle in simultaneous analysis of dopamine and serotonin is not only their similar detection potential but also the polymerization of dopamine at physiological pH, which results in sensitivity loss. In this work, we investigated glassy carbon electrodes and electrodes modified with carbon black, graphene oxide, and carbon nanodots in terms of their ability to detect 5 neurobiologically relevant analytes (dopamine, serotonin, epinephrine, norepinephrine, and 3,4‐dihydroxyphenylacetic acid). We proved that simultaneous detection of dopamine and serotonin in the presence of uric and ascorbic acids is possible on electrodes modified with carbon black and graphene oxide, both in buffer solution and cell medium. Graphene oxide‐modified electrodes have shown the highest sensitivity towards all tested neurotransmitters. Moreover, a considerable shift of epinephrine, norepinephrine, and 3,4‐dihydroxyphenylacetic acid peaks towards more negative potentials was observed for electrodes modified with carbon black and graphene oxide as compared with glassy carbon electrodes. Electrodes covered with carbon nanodots were proven inappropriate due to their surface functionalization with ethylenediamine.
Characterizing the COVID‐19 dynamics with a new epidemic model: Susceptible‐exposed‐asymptomatic‐symptomatic‐active‐removed
Authors: Yi Grace Y. , Hu Pingbo , He Wenqing 
Published: April 2022

AbstractThe coronavirus disease 2019 (COVID‐19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has spread stealthily and presented a tremendous threat to the public. It is important to investigate the transmission dynamics of COVID‐19 to help understand the impact of the disease on public health and the economy. In this article, we develop a new epidemic model that utilizes a set of ordinary differential equations with unknown parameters to delineate the transmission process of COVID‐19. The model accounts for asymptomatic infections as well as the lag between symptom onset and the confirmation date of infection. To reflect the transmission potential of an infected case, we derive the basic reproduction number from the proposed model. Using the daily reported number of confirmed cases, we describe an estimation procedure for the model parameters, which involves adapting the iterated filter‐ensemble adjustment Kalman filter (IF‐EAKF) algorithm. To illustrate the use of the proposed model, we examine the COVID‐19 data from Quebec for the period from 2 April 2020 to 10 May 2020 and carry out sensitivity studies under a variety of assumptions. Simulation studies are used to evaluate the performance of the proposed model under a variety of settings.
Integrating information from existing risk prediction models with no model details
Authors: Han Peisong , Taylor Jeremy M. G. , Mukherjee Bhramar 
Published: April 2022

AbstractConsider the setting where (i) individual‐level data are collected to build a regression model for the association between an event of interest and certain covariates, and (ii) some risk calculators predicting the risk of the event using less detailed covariates are available, possibly as algorithmic black boxes with little information available about how they were built. We propose a general empirical‐likelihood‐based framework to integrate the rich auxiliary information contained in the calculators into fitting the regression model, to make the estimation of regression parameters more efficient. Two methods are developed: one using working models to extract the calculator information and the other making a direct use of calculator predictions without working models. Theoretical and numerical investigations show that the calculator information can substantially reduce the variance of regression parameter estimation. As an application, we study the dependence of the risk of high‐grade prostate cancer on both conventional risk factors and newly identified molecular biomarkers by integrating information from the Prostate Biopsy Collaborative Group (PBCG) risk calculator, which was built based on conventional risk factors alone.
Atomic Layer Deposition of Gold Nanoparticles with Controlled Size and Distribution on Titania Support
Authors: Xie Huichen , Li Zheng , Zhu Jian , Li Can 
Published: April 2022

AbstractNano‐sized gold particles have shown unique merits in the field of catalysis, sensing and imaging, whereas their controllable synthesis with sub‐nanometer size and narrow distribution on a support still remains a challenge. Herein, we developed a facile and controllable process of atomic layer deposition (ALD) using dimethyl(acetylacetonate)gold (Me2Au(acac)) and ozone as the precursor reactants to directly synthesize ultrafine Au nanoparticles on titania support. The size of Au nanoparticles could be precisely controlled via the modulation of depositing temperature and the counter reactant. Additionally, the dispersion of Au nanoparticles on the support is decreased by pre‐calcining TiO2 in air, which is due to the decreased surface hydroxyls concentration on support, leading to less adsorption sites of gold precursor. Moreover, we demonstrated that Au nanoparticles prepared by this method on TiO2 could function as an effective co‐catalyst for photocatalytic hydrogen evolution reaction.
Driving Performance after Bedtime Administration of Daridorexant, Assessed in a Sensitive Simulator
Authors: Muehlan Clemens , Brooks Sander , Vaillant Cedric , Meinel Michael , Jacobs Gabriël E. , Zuiker Rob G. , Dingemanse Jasper 
Published: April 2022

Use of hypnotics is often associated with next‐morning residual effects and a higher risk of motor vehicle accidents. Measuring next‐morning effects on driving performance is therefore advised by regulatory agencies. Here, we examined driving performance following administration of daridorexant, a new dual orexin receptor antagonist developed to treat insomnia. Sixty healthy male and female subjects (50–79 years of age) were randomized in a placebo‐ and active‐controlled, four‐way cross‐over study. Each subject received evening administration of daridorexant 50 and 100 mg, zopiclone 7.5 mg, and placebo, in separate treatment phases of 4 days. Simulated driving performance was assessed after initial (day 2) and repeated dosing (day 5), 9 hours postdose. Standard deviation of the lateral position (SDLP) was the main outcome. On both days, with zopiclone, SDLP increased significantly compared with placebo, which confirmed sensitivity of the simulator. With daridorexant, on day 2, the placebo‐corrected mean (97.5% confidence interval) SDLP increased by 2.19 cm (0.46–3.93) and 4.43 cm (2.72–6.15) for 50 and 100 mg, respectively. On day 5, SDLP values for both daridorexant doses were significantly below the prespecified threshold of impairment (2.6 cm) and statistically not different from placebo. Daridorexant showed a lower self‐rated driving quality and higher effort compared to placebo on day 2 but not on day 5. In non‐insomnia subjects, daridorexant impaired simulated driving after initial but not after repeated dosing. Subjects should be cautioned about driving until they know how daridorexant affects them.
Sophoraflavanone G suppresses the progression of triple‐negative breast cancer via the inactivation of EGFR–PI3K–AKT signaling
Authors: Cheng Wei , Liu Dan , Guo Min , Li Honglei , Wang Qiang 
Published: April 2022

AbstractSophoraflavanone G (SG), a prenylated flavonoid extracted from Sophora flavescens, has been found to possess antitumor activity in several types of human cancer. However, the biological functions and molecular mechanism of SG in triple‐negative breast cancer (TNBC) are required to be investigated. On the basis of network pharmacology methods and molecular docking technology, estimated glomerular filtration rate (EGFR) was identified as a potential target, and phosphatidylinositol 3‑kinase–protein kinase B (PI3K–AKT) signaling was demonstrated as an important signaling pathway for SG to treat breast cancer. TNBC cells (BT‐549 and MDA‐MB‐231) were used to determine the effects of SG in vitro. Cell Counting Kit, 5‐ethynyl‐2′‐deoxyuridine, and colony formation assays confirmed the proliferation inhibition of SG on TNBC cells. Moreover, SG administration promoted cell apoptosis by affecting Bax, Bcl‐2, and cleaved caspase‐3 expression. SG treatment also enhanced oxidative stress of TNBC cells by inducing reactive oxygen species production, increasing malondialdehyde (MDA) level, and decreasing superoxide dismutase activity. Additionally, SG suppressed cell migration, invasion, and epithelial–mesenchymal transition process. Inactivated EGFR–PI3K–AKT signaling was observed in TNBC cells after treatment with SG. Furthermore, the inhibitory effects of SG on cell proliferation and metastasis and the promotive effects of SG on cell apoptosis and oxidative stress were significantly attenuated due to the overexpression of EGFR. Mice experiments revealed the suppression of SG on tumor growth and EGFR–PI3K–AKT signaling. Together, SG repressed the proliferation and metastasis, and induced apoptosis and oxidative stress in TNBC by targeting the EGFR–PI3K–AKT signaling pathway. SG might serve as a promising therapeutic agent to combat TNBC.
Can restoration of fire‐dependent ecosystems reduce ticks and tick‐borne disease prevalence in the eastern United States?
Authors: Gallagher Michael R. , Kreye Jesse K. , Machtinger Erika T. , Everland Alexis , Schmidt Nathaniel , Skowronski Nicholas S. 
Published: April 2022

AbstractOver the past century, fire suppression has facilitated broad ecological changes in the composition, structure, and function of fire‐dependent landscapes throughout the eastern US, which are in decline. These changes have likely contributed mechanistically to the enhancement of habitat conditions that favor pathogen‐carrying tick species, key wildlife hosts of ticks, and interactions that have fostered pathogen transmission among them and to humans. While the long‐running paradigm for limiting human exposure to tick‐borne diseases focuses responsibility on individual prevention, the continued expansion of medically important tick populations, increased incidence of tick‐borne disease in humans, and emergence of novel tick‐borne diseases highlights the need for additional approaches to stem this public health challenge. Another approach that has the potential to be a cost‐effective and widely applied but that remains largely overlooked is the use of prescribed fire to ecologically restore degraded landscapes that favor ticks and pathogen transmission. We examine the ecological role of fire and its effects on ticks within the eastern United States, especially examining the life cycles of forest‐dwelling ticks, shifts in regional‐scale fire use over the past century, and the concept that frequent fire may have helped moderate tick populations and pathogen transmission prior to the so‐called fire‐suppression era that has characterized the past century. We explore mechanisms of how fire and ecological restoration can reduce ticks, the potential for incorporating the mechanisms into the broader strategy for managing ticks, and the challenges, limitations, and research needs of prescribed burning for tick reduction.
Incorporating Sodium to Boost the Activity of Aluminium TrenSal Complexes towards rac‐Lactide Polymerisation
Authors: Zhou Yali , Nichol Gary S. , Garden Jennifer A. 
Published: April 2022

AbstractFour novel homo‐ and heterometallic sodium and/or aluminium complexes based on the TrenSal ligand, [LH3], have been synthesised and fully characterised, including by single‐crystal X‐ray diffraction experiments. While [LAl] was completely inactive towards rac‐lactide ring‐opening polymerisation, incorporating sodium to form heterometallic [LNaAlMe] changes the aluminium geometry from octahedral to tetrahedral, leading to good catalytic activity in the presence of co‐initiator BnOH (kobs=3.19×10−2 min−1; room temperature, toluene solvent) and good polymerisation control. Under identical conditions, homometallic sodium complexes showed higher activities in rac‐lactide polymerisation than [LNaAlMe], with [LNa3] being extremely active (kobs=1.21 min−1) but displaying unusual second‐order monomer dependency and poor polymerisation control. 1H NMR spectroscopic studies suggest that polymerisation with [LNaAlMe] or [LH2Na]/BnOH follows an activated monomer mechanism, whereas [LNa3] operates via simultaneous coordination‐insertion and activated monomer mechanisms. Overall, heterometallic [LNaAlMe] provides a balance of good activity and control compared to the homometallic analogues.
Purification of pluripotent embryonic stem cells using dielectrophoresis and a flow control system
Authors: Kiryo Tetsushi , Takahashi Yuuwa , Miyata Shogo 
Published: April 2022

AbstractPluripotent stem cells (PSCs) such as embryonic stem cells and induced PSCs can differentiate into all somatic cell types such as cardiomyocytes, nerve cells, and chondrocytes. However, PSCs can easily lose their pluripotency if the culture process is disturbed. Therefore, cell sorting methods for purifying PSCs with pluripotency are important for the establishment and expansion of PSCs. In this study, we focused on dielectrophoresis (DEP) to separate cells without fluorescent dyes or magnetic antibodies. The goal of this study was to establish a cell sorting method for the purification of PSCs based on their pluripotency using DEP and a flow control system. The dielectrophoretic properties of mouse embryonic stem cells (mESCs) with and without pluripotency were evaluated in detail, and mESCs exhibited varying frequency dependencies in the DEP response. Based on the variance in DEP properties, mixed cell suspensions of mESCs can be separated according to their pluripotency with an efficacy of approximately 90%.
Brain network hierarchy reorganization in Alzheimer's disease: A resting‐state functional magnetic resonance imaging study
Authors: Hu Qili , Li Yunfei , Wu Yunying , Lin Xiaomei , Zhao Xiaohu 
Published: April 2022

AbstractHierarchy is a fundamental organizational principle of the human brain network. Whether and how the network hierarchy changes in Alzheimer's disease (AD) remains unclear. To explore brain network hierarchy alterations in AD and their clinical relevance. Forty‐nine healthy controls (HCs), 49 patients with mild cognitive impairment (MCI), and 49 patients with AD were included. The brain network hierarchy of each group was depicted by connectome gradient analyses. We assessed the network hierarchy changes by comparing the gradient values in each network across the AD, MCI, and HC groups. Whole‐brain voxel‐level gradient values were compared across the AD, MCI, and HC groups to identify abnormal brain regions. Finally, we examined the relationships between altered gradient values and clinical features. In the secondary gradient, the posterior default mode network (DMN) gradient values decreased significantly in patients with AD compared with HCs. Regionally, compared with HCs, both MCI and AD groups showed that most of the brain regions with increased gradient values were located in anterior DMN, while most of the brain regions with decreased gradient values were located in posterior DMN. The decrease of gradients in the left middle occipital gyrus was associated with better logical memory performance. The increase of gradients in the right middle frontal gyrus was associated with lower rates of dementia. The network hierarchy changed characteristically in patients with AD and was closely related to memory function and disease severity. These results provide a novel view for further understanding the underlying neuro‐mechanisms of AD.
Sentinel lymph node biopsy for early squamous cell carcinoma of the lip and oral cavity: Real‐world experience in Brazil
Authors: Matos Leandro Luongo , Capuzzo Renato Castro , Pedruzzi Paola Andrea Galbiatti , Farias Terence , de Farias José Wilson Mourão , Chone Carlos Takahiro , Köhler Hugo Fontan , Vartanian José Guilherme , Dias Fernando Luiz , Couto Eduardo Vieira , Pinto Fabio Roberto , Carvalho André Lopes , Kowalski Luiz Paulo 
Published: April 2022

AbstractBackgroundThis study aimed to evaluate the accuracy and oncological results of sentinel lymph node biopsy in patients with early lip and oral cavity squamous cell carcinoma (SCC) in a real‐world scenario.MethodsRetrospective study including seven Brazilian centers.ResultsFour‐hundred and seven cN0 patients were accrued for 20 years. The rate of occult metastasis was 23.1% and 22 patients (5.4%) had regional failure. We found, for 5 years of follow‐up, 85.3% of regional recurrence‐free survival; 77.1% of disease‐free survival; 73.7% of overall survival; and 86.7% of disease‐specific survival. The rate of false‐negative cases was 5.4%.ConclusionIn a real‐world scenario, sentinel lymph node biopsy for patients with SCC of the lip and oral cavity proved feasible in different settings and to be oncologically safe, with similar rates of occult lymph node metastasis and false‐negative cases, when compared to elective neck dissection, and with similar long‐term survival to that reported historically.
Influence of previous delivery mode on perineal trauma risk
Authors: Thorne Elizabeth P. C. , Durnea Constantin M. , Sedgwick Philip M. , Doumouchtsis Stergios K. 
Published: April 2022

AbstractObjectiveTo evaluate the impact of a previous pregnancy and delivery on perineal trauma rates in the subsequent vaginal birth.MethodsRetrospective cohort study. The perineal outcomes of secundiparous women with history of previous (first) delivery in one of three categories: failed operative vaginal delivery (FOVD) and second‐stage emergency cesarean section (EmCS); elective cesarean section (ElCS), and vaginal delivery (VD) with intact perineum, were compared with a control primiparous group.ResultsThe percentage obstetric anal sphincter injuries (OASIS)at first vaginal delivery was 17.3% (n = 9) after previous FOVD+EmCS, 12.9% (n = 18) after previous ElCS, and 0.6% (n = 9) after previous VD maintaining an intact perineum, compared with 6% (n = 1193) in the control primiparous group of women. Multivariate regression analysis demonstrated that previous FOVD+EmCS and ElCS were associated with a statistically significant increased risk of OASIS of 180% and 110% when compared with control (odds ratio [OR] 2.80; 95% confidence interval [CI] 1.35–5.78 and OR 2.10; 95% CI 1.27–3.48, respectively). Previous VD with intact perineum was associated with a statistically significantly reduced risk of OASIS (OR 0.09; 95% CI 0.04–0.17).ConclusionsPrevious FOVD+EmCS and ElCS were associated with increased risk of OASIS in subsequent vaginal delivery compared with control, whereas previous VD with intact perineum was associated with decreased risk.
Risk factors for immediate failure of outpatient surgery in gynecologic surgery
Authors: Siebert David , Giraudet Géraldine , Collinet Pierre , Gonzalez Estevez Max , Cosson Michel , Rubod Chrystèle 
Published: April 2022

AbstractObjectiveTo describe the risk factors for immediate failure of gynecologic outpatient surgery. The secondary objective was to describe the risk factors for rehospitalization within 30 days after surgery.MethodsThis is a single‐center retrospective cohort study conducted on all patients operated on in outpatient surgery in gynecology at the Lille University Hospital. The primary outcome was defined as any unanticipated admission to the inpatient postoperative care unit on the day of the operation. The secondary outcome was defined as any rehospitalization within 30 days following the intervention. Our statistical analysis included 916 patients operated on between January and July 2019.ResultsIn our study, 84 patients (9.2%) had an immediate failure of outpatient surgery. The most frequent etiologies were surgical (58.3%). In multivariate analysis with logistic regression, the following variables were associated with an increased risk of immediate failure of outpatient surgery: urogynecologic surgery (P < 0.001), complex laparoscopy (P = 0.004), endometriosis surgery (P < 0.001), and a duration of intervention longer than 1 hour (P < 0.001).ConclusionWe find an increased risk of immediate failure of gynecologic outpatient surgery depending on the type of surgery as well as for surgeries lasting more than 1 hour.