bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mengajar Kreatif Dengan Google Classroom Bagi Guru Sd Negeri 096 Manyabar
Authors: Putra Guntur Maha , Atikah Nurul , Mahfuz Rizky Putri , Rahmadhani Dessy , Tanjun Selma Karamy Zulpana , Anggina Putri 
Published: February 2022

Abstract: This Community Service activity was carried out at SD Negeri 096 Manyabar, Panyabungan District, Mandailing Natal Regency, North Sumatra. This activity is carried out with the aim of helping adapt technology that is in line with the MBKM (Merdeka Belajar – Kampus Merdeka) program, one of which is the use of the google classroom platform in the process of e-learning teaching and learning activities in schools to create creative, interactive, effective and efficient learning between teachers and students, especially during this Covid-19 pandemic. Google classroom is a free, web-based platform built to make it easier for educators and students to learn online, which is easy to use to help teachers manage, measure, and experiential learning. The current use of Google Classroom is very efficient which is not limited by effective space and time. Teachers can provide online material, either in the form of text, images, audio, or video to students, besides that teachers can also make quizzes, assignments, and student lists on a regular basis by using a link from the google form sent to google classroom. Online learning in this Covid-19 era makes learning activities can be carried out interactively, effectively, and efficiently between teachers and students by utilizing technology, one of which is the use of the google classroom platform. Keywords: google classroom; online learning; e-learning Abstrak: Kegiatan Pengabdian Masyarakat ini dilaksanakan di SD Negeri 096 Manyabar, Kecamatan Panyabungan, Kabupaten Mandailing Natal, Sumatera Utara. Kegiatan ini dilaksanakan bertujuan dalam hal membantu adaptasi teknologi yang selaras dengan program MBKM (Merdeka Belajar – Kampus Merdeka) yang salah satunya adalah dengan pemanfaatan plafform google classroom dalam proses kegiatan belajar mengajar e-learning di sekolah untuk menciptakan pembelajaran kreatif, interaktif, efektif dan efisien antara guru dengan siswa apalagi dimasa pandemi Covid-19 ini. Google classroom adalah platform gratis berbasis web yang dibuat untuk mempermudah kegiatan pembelajaran pendidik dan siswa secara online yang mudah digunakan untuk membantu pengajar mengelola, mengukur, dan memperkaya pengalaman belajar. Pemanfaatan Google classroom saat ini sangat efektif dan efisien yang tidak terbatas oleh ruang dan waktu. Guru dapat memberikan materi secara online, baik berupa teks, gambar, audio, maupun video kepada peserta didik, selain itu guru juga dapat membuat kuis, tugas maupun daftar kehadiran siswa secara berkala dengan menggunakan link dari google form yang dikirimkan ke google classroom. Pembelajaran secara daring dimasa Covid-19 ini membuat kegiatan belajar dapat dilakukan secara interaktif, efektif dan efisien antara guru dengan siswa dengan pemanfaatan teknologi salah satu dengan pemanfaatan plafform google classroom.Kata kunci: google classroom; pembelajaran daring; e-learning
Kepemilikan Manajerial dan Kepemilikan Institusional Terhadap Kebijakan Hutang Pada Perusahaan Manufaktur si BEI Tahun 2016-2019
Authors: Kartikasari Evi , Dewi Arfiana , Sulton Muhammad 
Published: February 2022

Kinerja perusahaan yang baik dapat dilihat dari kinerja keuangan perusahaan, selain itu juga dapat dilihat dari kebijakan yang tepat yang dilaksanakan oleh manajemen perusahaan. Kebijakan di dalam perusahaan merupakan cerminan langkah manajerial untuk mengambil keputusan. Kebijakan hutang merupakan keputusan pendanaan dari pihak eksternal yang diambil oleh perusahaan guna untuk mengembangkan perusahaan, perluasan modal dan usaha serta untuk mendanai operasional perusahaan. Penggunaan hutang dapat meningkatkan risiko perusahaan, karena ketika perusahaan tidak mampu melunasi hutangnya maka akan terancam likuiditasnya, sehingga manajemen harus mampu mengambil keputusan yang sesuai dan tepat untuk meminimalisir risiko yang akan ditanggung oleh perusahaanHutang dapat sangat membantu dalam mengatasi masalah pendanaan, akan tetapi perlu dipertimbangkan risiko akan terjadinya kebangkrutan pada penggunaan hutang dalam jumlah yang besar. Tujuan dari penelitian ini yaitu untuk mengetahui pengaruh kepemilikan manajerial dan kepemilikan institusional terhadap kebijakan hutang perusahaan Manufaktur yang terdaftar di BEI Tahun 2016-2019. Jenis penelitian yang digunakan dalam penelitian ini adalah deskriptif dengan pendekatan kuantitatif berfokus pada pengujian hipotesis sesuai dengan model analisis yang ditentukan kemudian mendeskripsikan hasilnya. Jenis data yang digunakan adalah data sekunder yaitu berupa data laporan tahunan perusahaan manufaktur yang terdaftar di bursa efek Indonesia tahun 2016-2019 yang diambil (download) dari website perusahaan terkait dan website http://www.idx.co.id. Populasi sebanyak 169 Perusahaan dengan Teknik sampling nonprobability sampling jenis purposive sampling. Jumlah sampel yang sesuai kreteria sebanyak 91 perusahaan dengan total data 364 data penelitian. Teknik analisis data yang digunakan dalam penelitian ini yaitu analisis regresi linier berganda dengan menggunakan alat bantu software statistik SPSS Ver. 25.
Analisis Molecular Docking Senyawa dari Jamur Endofit Bawang Dayak (Eleutherine bulbosa) Sebagai Inhibitor Lipase Pankreas
Authors: Naibaho Frans Grovy , Putra Ebrry Dwi , Panjaitan4 Desimaria , Wardhana Vinsen Willi 
Published: February 2022

Nowadays some efforts are being made to reduce obesity by using drugs that aim to reduce appetite of the drug users. However, the use of drugs still has harmful side effects. Endophytic fungi originating from the Dayak onion plant are thought to have secondary metabolites that have potential as anti-obesity. The aims of this study were to determine the compounds produced by endophytic fungi of Dayak onion and to determine the potential components as inhibitors of pancreatic lipase enzymes. Samples of Dayak onions were collected from Palangka Raya using purposive sampling method. Isolation of endophytic fungi was conducted using surface sterilization method and the isolates were grown on PDA. Isolates were characterized and fermented on PDB for 14 days. The selected isolate was analyzed by using GCMS then molecular docking was performed using Autodock Vina and PyRx. The research results showed that there were 7 isolates of endophytic fungi isolated from leaves and roots tissues of Dayak onion. GCMS analysis showed that EBD1 contains 38 compounds. Molecular docking analysis showed that 1,3-Di-O-Acetylpentopyranose, a test ligand, has the closest binding affinity value (-6.6 kcal/mol) to orlistat (control) (-6.8 kcal/mol). Thus, it has the potential as an inhibitor of pancreatic lipase enzyme protein.
Nonmuscle Myosin II is Required for Larval Shell Formation in a Patellogastropod
Authors: Liu Xinyu , Huan Pin , Liu Baozhong 
Published: February 2022

The molecular mechanisms underlying larval shell development in mollusks remain largely elusive. We previously found evident filamentous actin (F-actin) aggregations in the developing shell field of the patellogastropod Lottia goshimai, indicating roles of actomyosin networks in the process. In the present study, we functionally characterized nonmuscle myosin II (NM II), the key molecule in actomyosin networks, in the larval shell development of L. goshimai. Immunostaining revealed general colocalization of phosphorylated NM II and F-actin in the shell field. When inhibiting the phosphorylation of NM II using the specific inhibitor blebbistatin in one- or 2-h periods during shell field morphogenesis (6–8 h post-fertilization, hpf), the larval shell plate was completely lost in the veliger larva (24 hpf). Scanning electron microscopy revealed that the nascent larval shell plate could not be developed in the manipulated larvae (10 hpf). Further investigations revealed that key events in shell field morphogenesis were inhibited by blebbistatin pulses, including invagination of the shell field and cell shape changes and cell rearrangements during shell field morphogenesis. These factors caused the changed morphology of the shell field, despite the roughly retained “rosette” organization. To explore whether the specification of related cells was affected by blebbistatin treatments, we investigated the expression of four potential shell formation genes (bmp2/4, gata2/3, hox1 and engrailed). The four genes did not show evident changes in expression level, indicating unaffected cell specification in the shell field, while the gene expression patterns showed variations according to the altered morphology of the shell field. Together, our results reveal that NM II contributes to the morphogenesis of the shell field and is crucial for the formation of the larval shell plate in L. goshimai. These results add to the knowledge of the mechanisms of molluskan shell development.
Effect of Exercise Prescription Implementation Rate on Cardiovascular Events
Authors: Zhu Li-Yue , Li Min-Yan , Li Kun-Hui , Yang Xiao , Yang Yi-Yong , Zhao Xiao-Xia , Yan Ting , Li Meng-Meng , Luo Si-Qi , Zhang Mu-Lan , Su Jin-Zi 
Published: February 2022

BackgroundExercise prescription of cardiac rehabilitation (CR) is vital in patients with cardiovascular diseases (CVDs) and those carrying high risk for CVDs. However, the relation between the implementation rate of exercise prescription and cardiovascular events (CVEs) is unclear.Design and MethodsIn this retrospective study, using the administration data from the Rehabilitation Center in a hospital, patients aged ≥18 years with CVDs were consecutively enrolled from November 2018 to May 2021. Patients were divided into the high execution group (HEG) and low execution group (LEG) depending on whether they completed more than half the time of the exercise prescriptions. Baseline characteristics, ultrasonic cardiogram, cardiopulmonary exercise test, follow-up data, and CVEs were collected.ResultsThe mean age of the 197 CR patients was 61.8 ± 13.7 years and the mean follow-up duration was 10.9 ± 4.2 months. Among them, 15 patients suffered CVEs: 4 in the HEG and 11 in the LEG. The incidence of CVEs showed significant differences between HEG and LEG (chi-square test). Free-event survival analysis using Kaplan–Meier survival plots showed that patients in LEG had poor survival. Cox proportional hazards regression analysis revealed that the prescription implementation rate was an independent predictor of CVEs.ConclusionsOur study suggested a significant effect of exercise prescription execution rate on the occurrence of CVEs. Further, the HEG of exercise prescription was associated with lower CVDs.
Computed-Tomography as First-line Diagnostic Procedure in Patients With Out-of-Hospital Cardiac Arrest
Authors: Adel John , Akin Muharrem , Garcheva Vera , Vogel-Claussen Jens , Bauersachs Johann , Napp L. Christian , Schäfer Andreas 
Published: February 2022

BackgroundMortality after out-of-hospital cardiac arrest (OHCA) with return of spontaneous circulation (ROSC) remains high despite numerous efforts to improve outcome. For patients with suspected coronary cause of arrest, coronary angiography is crucial. However, there are other causes and potentially life-threatening injuries related to cardiopulmonary resuscitation (CPR), which can be detected by routine computed tomography (CT).Materials and MethodsAt Hannover Medical School, rapid coronary angiography and CT are performed in successfully resuscitated OHCA patients as a standard of care prior to admission to intensive care. We analyzed all patients who received CT following OHCA with ROSC over a three-year period.ResultsThere were 225 consecutive patients with return of spontaneous circulation following out-of-hospital cardiac arrest. Mean age was 64 ± 13 years, 75% were male. Of them, 174 (77%) had witnessed arrest, 145 (64%) received bystander CPR, and 123 (55%) had a primary shockable rhythm. Mean time to ROSC was 24 ± 20 min. There were no significant differences in CT pathologies in patients with or without ST-segment elevations in the initial ECG. Critical CT findings qualifying as a potential cause for cardiac arrest were intracranial bleeding (N = 6), aortic dissection (N = 5), pulmonary embolism (N = 17), pericardial tamponade (N = 3), and tension pneumothorax (N = 11). Other pathologies were regarded as consequences of CPR and relevant for further treatment: aspiration (N = 62), rib fractures (N = 161), sternal fractures (N = 50), spinal fractures (N = 11), hepatic bleeding (N = 12), and intra-abdominal air (N = 3).ConclusionEarly CT fallowing OHCA uncovers a high number of causes and consequences of OHCA and CPR. Those are relevant for post-arrest care and are frequently life-threatening, suggesting that CT can contribute to improving prognosis following OHCA.
Elevation of Hemoglobin A1c Increases the Atherosclerotic Plaque Vulnerability and the Visit-to-Visit Variability of Lipid Profiles in Patients Who Underwent Elective Percutaneous Coronary Intervention
Authors: Li Duanbin , Li Ya , Wang Cao , Jiang Hangpan , Zhao Liding , Hong Xulin , Lin Maoning , Luan Yi , Shen Xiaohua , Chen Zhaoyang , Zhang Wenbin 
Published: February 2022

BackgroundIncreased plaque vulnerability and higher lipid variability are causes of adverse cardiovascular events. Despite a close association between glucose and lipid metabolisms, the influence of elevated glycated hemoglobin A1c (HbA1c) on plaque vulnerability and lipid variability remains unclear.MethodsAmong subjects undergoing percutaneous coronary intervention (PCI) from 2009 through 2019, 366 patients received intravascular optical coherence tomography (OCT) assessment and 4,445 patients underwent the scheduled follow-ups within 1 year after PCI. Vulnerability features of culprit vessels were analyzed by OCT examination, including the assessment of lipid, macrophage, calcium, and minimal fibrous cap thickness (FCT). Visit-to-visit lipid variability was determined by different definitions including standard deviation (SD), coefficient of variation (CV), and variability independent of the mean (VIM). Multivariable linear regression analysis was used to verify the influence of HbA1c on plaque vulnerability features and lipid variability. Exploratory analyses were also performed in non-diabetic patients.ResultsAmong enrolled subjects, the pre-procedure HbA1c was 5.90 ± 1.31%, and the average follow-up HbA1c was 5.98 ± 1.16%. By OCT assessment, multivariable linear regression analyses demonstrated that patients with elevated HbA1c had a thinner minimal FCT (β = −6.985, P = 0.048), greater lipid index (LI) (β = 226.299, P = 0.005), and higher macrophage index (β = 54.526, P = 0.045). Even in non-diabetic patients, elevated HbA1c also linearly decreased minimal FCT (β = −14.011, P = 0.036), increased LI (β = 290.048, P = 0.041) and macrophage index (β = 120.029, P = 0.048). Subsequently, scheduled follow-ups were performed during 1-year following PCI. Multivariable linear regression analyses proved that elevated average follow-up HbA1c levels increased the VIM of lipid profiles, including low-density lipoprotein cholesterol (β = 2.594, P &lt; 0.001), high-density lipoprotein cholesterol (β = 0.461, P = 0.044), non-high-density lipoprotein cholesterol (β = 1.473, P &lt; 0.001), total cholesterol (β = 0.947, P &lt; 0.001), and triglyceride (β = 4.217, P &lt; 0.001). The result was consistent in non-diabetic patients and was verified when SD and CV were used to estimate variability.ConclusionIn patients undergoing elective PCI, elevated HbA1c increases the atherosclerotic plaque vulnerability and the visit-to-visit variability of lipid profiles, which is consistent in non-diabetic patients.
Uric Acid Mediated the Association Between BMI and Postmenopausal Breast Cancer Incidence: A Bidirectional Mendelian Randomization Analysis and Prospective Cohort Study
Authors: Feng Yue , Fu Ming , Guan Xin , Wang Chenming , Yuan Fangfang , Bai Yansen , Meng Hua , Li Guyanan , Wei Wei , Li Hang , Li Mengying , Jie Jiali , Lu Yanjun , Guo Huan 
Published: February 2022

BackgroundObservational epidemiological studies have reported the associations of high body mass index (BMI) with elevated serum uric acid (UA) level and increased risk of postmenopausal breast cancer. However, whether UA is causally induced by BMI and functioned in the BMI–breast cancer relationship remains unclear.MethodsTo elucidate the causality direction between BMI and serum UA, the bidirectional Mendelian randomization (MR) analyses were performed by using summarized data from the largest Asian genome-wide association studies (GWAS) of BMI and UA carried out in over 150,000 Japanese populations. Then, a total of 19,518 postmenopausal women from the Dongfeng–Tongji (DFTJ) cohort (with a mean 8.2-year follow-up) were included and analyzed on the associations of BMI and serum UA with incidence risk of postmenopausal breast cancer by using multivariable Cox proportional hazard regression models. Mediation analysis was further conducted among DFTJ cohort to assess the intermediate role of serum UA in the BMI–breast cancer association.ResultsIn the bidirectional MR analyses, we observed that genetically determined BMI was causally associated with elevated serum UA [β(95% CI) = 0.225(0.111, 0.339), p &lt; 0.001], but not vice versa. In the DFTJ cohort, each standard deviation (SD) increment in BMI (3.5 kg/m2) and UA (75.4 μmol/l) was associated with a separate 24% and 22% increased risk of postmenopausal breast cancer [HR(95% CI) = 1.24(1.07, 1.44) and 1.22(1.05, 1.42), respectively]. More importantly, serum UA could mediate 16.9% of the association between BMI and incident postmenopausal breast cancer.ConclusionsThe current findings revealed a causal effect of BMI on increasing serum UA and highlighted the mediating role of UA in the BMI–breast cancer relationship. Controlling the serum level of UA among overweight postmenopausal women may help to decrease their incident risk of breast cancer.
The Prevalence of Islet Autoantibodies in Children and Adolescents With Type 1 Diabetes Mellitus: A Global Scoping Review
Authors: Ross Carlo , Ward Zachary J. , Gomber Apoorva , Owais Maira , Yeh Jennifer M. , Reddy Ché-L. , Atun Rifat 
Published: February 2022

Background and PurposePancreatic islet autoantibodies (iAb) are the hallmark of autoimmunity in type 1 diabetes. A more comprehensive understanding of the global iAb prevalence could help reduce avertible morbidity and mortality among children and adolescents and contribute to the understanding in the observed differences in the incidence, prevalence and health outcomes of children and adolescents with type 1 diabetes across and within countries. We present the first scoping review that provides a global synthesis of the prevalence of iAb in children and adolescents with type 1 diabetes.Research Design and MethodsWe searched Ovid MEDLINE® with Daily Update, Embase (Elsevier, embase.com) and PubMed (National Library of Medicine -NCBI), for studies pertaining to prevalence in children and adolescents (0-19) with type 1 diabetes published between 1 Jan 1990 and 18 June 2021. Results were synthesized using Covidence systematic review software and meta-analysis was completed using R v3·6·1. Two reviewers independently screened abstracts with a third reviewer resolving conflicts (k= 0·92).ResultsThe review revealed 125 studies from 48 different countries, with 92 from high-income countries. Globally, in new-onset type 1 diabetes, IA-2A was the most prevalent iAb 0·714 [95% CI (0·71, 0·72)], followed by ICA 0·681 [95% CI (0·67, 0·69)], ZnT8A was 0·654 [95% CI (0·64, 0·66)], GADA 0·636 [95% CI (0·63, 0·66)] and then IAA 0·424 [95% CI (0·42, 0·43)], with substantial variation across world regions. The weighted mean prevalence of IA-2A was more variable, highest in Europe at 0·749 [95% CI (0·74, 0·76)] followed by Northern America 0·662 [95% CI (0·64, 0·69)], Latin America and the Caribbean 0·632 [95% CI (0·54, 0·72)], Oceania 0·603 [95% CI (0·54, 0·67)], Asia 0·466 [95% CI (0·44, 0·50)] and Africa 0·311 [95% CI (0·23, 0·40)]. In established cases of type 1 diabetes, GADA was the most prevalent iAb 0·407 [95% CI (0·39, 0·42)] followed by ZnT8A 0·322 [95% CI (0·29, 0·36)], IA-2A 0·302 [95% CI (0·29, 0·32)], IAA 0·258 [95% CI (0·24, 0·26)] and ICA 0·145 [95% CI (0·13, 0·16)], again with substantial variation across world regions.ConclusionUnderstanding the global prevalence of iAb in children and adolescents with type 1 diabetes could help with earlier identification of those at-risk of developing type 1 diabetes and inform clinical practice, health policies, resource allocation, and targeted healthcare interventions to better screen, diagnose and manage children and adolescents with type 1 diabetes
The Effect of Aging on Quality of Life in Acromegaly Patients Under Treatment
Authors: Yamamoto Naoki , Urai Shin , Fukuoka Hidenori , Yamamoto Masaaki , Yoshida Kenichi , Suzuki Masaki , Shichi Hiroki , Fujita Yasunori , Kanie Keitaro , Iguchi Genzo , Takahashi Yutaka , Ogawa Wataru 
Published: February 2022

ContextWith the increasing number of older patients with acromegaly, it is important to understand the effects of aging on the quality of life (QoL) in acromegaly.ObjectiveTo investigate the factors associated with the QoL of older acromegaly patients.DesignThis was a single-center, retrospective, cross-sectional study conducted between 2014 and 2019.MethodsAmong 90 acromegaly patients at Kobe University Hospital, 74 who had completed the QoL evaluation under treatment were enrolled (age = 62.0 [50.7–70.0], female 52%). SF-36 and the AcroQoL questionnaire were used to quantify QoL. The patients were divided into two groups: the young and middle-aged group, aged &lt;65 years (51.0 [46.0–59.2], n =42), and the older group, aged ≥65 years (70.5 [69.0–73.0], n =32). The factors associated with the QoL scores were analyzed using univariate and multivariate regression analyses.ResultsThe scores for the physical component summary of SF-36 were negatively associated with age (P &lt;0.01), while those for the mental or role/social component summary were positively associated (P &lt;0.01, P =0.03, respectively). In contrast, AcroQoL scores were not associated with age. However, the different factors were associated with lower AcroQoL scores; arthropathy and higher BMI in the older group (P &lt;0.01, and P =0.01, respectively), and treatment modalities and size of pituitary tumor in the young and middle-aged group (P &lt;0.01, P =0.04, respectively). Replacement of hydrocortisone was commonly associated both in young and middle-aged group (P =0.04), and in older group (P =0.02).ConclusionWe showed that the factors associated with impaired QoL differed in the young and middle-aged, and older patients with acromegaly. In older patients, arthropathy and higher BMI were associated with poor QoL. These suggest the importance of early diagnosis and appropriate treatment in preventing arthropathy in acromegaly.