bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structure-function coupling as a correlate and potential biomarker of cognitive impairment in multiple sclerosis
Authors: Kulik Shanna D. , Nauta Ilse M. , Tewarie Prejaas , Koubiyr Ismail , van Dellen Edwin , Ruet Aurelie , Meijer Kim A. , de Jong Brigit A. , Stam Cornelis J. , Hillebrand Arjan , Geurts Jeroen J. G. , Douw Linda , Schoonheim Menno M. 
Published: January 2022

Abstract
Multiple sclerosis (MS) features extensive connectivity changes, but how structural and functional connectivity relate, and whether this relation could be a useful biomarker for cognitive impairment in MS is unclear. This study included 79 MS patients and 40 healthy controls (HCs). Patients were classified as cognitively impaired (CI) or cognitively preserved (CP). Structural connectivity was determined using diffusion MRI and functional connectivity using resting-state magnetoencephalography (MEG) data (theta, alpha1, and alpha2 bands). Structure-function coupling was assessed by correlating modalities, and further explored in frequency bands that significantly correlated with whole-brain structural connectivity. Functional correlates of short- and long-range structural connections (based on tract length) were then specifically assessed. Receiving operating curve analyses were performed on coupling values to identify biomarker potential. Only the theta band showed significant correlations between whole-brain structural and functional connectivity (rho = −0.26, p = 0.023, only in MS). Long-range structure-function coupling was stronger in CI patients compared to HCs (p = 0.005). Short-range coupling showed no group differences. Structure-function coupling was not a significant classifier of cognitive impairment for any tract length (short-range area under the curve (AUC) = 0.498, p = 0.976, long-range AUC = 0.611, p = 0.095). Long-range structure-function coupling was stronger in CI MS compared to HCs, but more research is needed to further explore this measure as biomarkers in MS.
Uncertainty in Integrated Assessment Modeling of Climate Change
Authors: Tavoni Massimo , Valente Giovanni 
Published: January 2022

Abstract
Integrated assessment models (IAMs) play a major role in the science and policy of climate change. Similarly to other widely used computational tools for addressing socially relevant problems, IAMs need to account for the key uncertainties characterizing processes and socio-economic responses. In the case of climate change, these are particularly complex given the very long-term nature of climate and the deep uncertainty characterizing technological and human systems. Here we draw from philosophical discussion of mathematical modeling of social problems and review the role of uncertainty in climate-economic modeling. In agreement with the literature, we highlight the crucial role of epistemic uncertainty in IAMs. We posit that the normative components of models, more than the physical and socio-techno-economic ones, are the most fraught by uncertainty and yet the least understood. We suggest a research agenda to explore uncertainties of evaluation frameworks, transcending the current implicit normativity of IAMs.
Catchment Profile of Large Cochlear Implant Centers in the United States
Authors: Nassiri Ashley M. , Holcomb Meredith A. , Perkins Elizabeth L. , Bucker Andrea L. , Prentiss Sandra M. , Welch Christopher M. , Andresen Nick S. , Valenzuela Carla V. , Wick Cameron C. , Angeli Simon I. , Sun Daniel Q. , Bowditch Stephen P. , Brown Kevin D. , Zwolan Teresa A. , Haynes David S. , Saoji Aniket A. , Carlson Matthew L. 
Published: January 2022

ObjectiveTo characterize the catchment area and patient profile of large cochlear implant (CI) centers in the United States.Study DesignMulti‐institutional retrospective case series.SettingTertiary referral CI centers.MethodsPatients who underwent CI surgery at 7 participating CI centers between 2015 and 2020 were identified. Patients’ residential zip codes were used to approximate travel distances and urban vs rural residential areas.ResultsOver the 6‐year study period (2015‐2020), 6313 unique CI surgical procedures occurred (4529 adult, 1784 pediatric). Between 2015 and 2019, CI procedures increased by 43%. Patients traveled a median 52 miles (interquartile range, 21‐110) each way; patients treated at rural CI centers traveled greater distances vs those treated at urban centers (72 vs 46 miles, P <. 001). Rural residents represented 61% of the patient population and traveled farther than urban residents (73 vs 24 miles, P <. 001). Overall, 91% of patients lived within a 200‐mile radius of the institution, while 71% lived within a 100‐mile radius. In adults, multiple regression analysis redemonstrated an association between greater travel distances and (1) older age at the time of CI and (2) residential rural setting (both P <. 001, r2 = 0.2).ConclusionsWhile large CI centers serve geographically dispersed populations, most patients reside within a 200‐mile radius. Strategies to expand CI utilization may leverage remote programming, telemedicine, and strategic placement of new centers and satellite clinics to ameliorate travel burden.
Significance of very-low-voltage coagulation plus coverage with polyglycolic acid sheet after bullectomy for primary spontaneous pneumothorax
Authors: Shigefuku Shunsuke , Takahashi Hidenobu , Ito Maki , Kajiwara Naohiro , Ohira Tatsuo , Ikeda Norihiko 
Published: January 2022

Background The purpose of this study was to clarify the efficacy of the combination of low-voltage coagulation plus staple line coverage with a polyglycolic acid sheet after bullectomy for primary spontaneous pneumothorax to prevent a postoperative recurrence. Methods A total of 143 patients who underwent bullectomy for primary spontaneous pneumothorax between January 2014 and December 2019 were enrolled in this study. We classified the patients into two groups based on additional procedures after bullectomy, namely, low-voltage coagulation for the margin of the staple line plus coverage with a polyglycolic acid sheet (Group A) and staple line coverage with a polyglycolic acid sheet alone (Group B). We evaluated perioperative factors and recurrence-free survival after surgery in the two groups. Results Nine patients in Group B developed postoperative recurrences. In contrast, there was no postoperative recurrence in Group A. According to the Kaplan–Meier curves, the 2-year recurrence-free survival rates of the patients were 100% and 90.3%, in Group A and Group B, respectively. The log-rank test showed a significant difference between the two groups ( p = 0.031). Conclusion Low-voltage coagulation for the margin of a staple line plus coverage with a polyglycolic acid sheet is a useful option as an additional technique after bullectomy for primary spontaneous pneumothorax to prevent a postoperative recurrence.
The prevalence and incidence of HIV in the ART era (2006–2016) in North West Tanzania
Authors: Mosha Neema R , Todd Jim , Mukerebe Crispin , Marston Milly , Colombe Soledad , Clark Benjamin , Beard James , Mtenga Baltazar , Slaymaker Emma , Boerma Ties , Zaba Basia , Urassa Mark 
Published: January 2022

Background Sub-Saharan countries bear a disproportionate percentage of HIV infections and HIV-related deaths despite the efforts to strengthen HIV prevention and treatments services, including ART. It is important to demonstrate how these services have contributed to reducing the epidemic using available population data. Methods We estimated the prevalence and incidence rates from a cohort running over 23 years in Magu District, Mwanza Region-North West Tanzania. Adults 15 years and over who were residents of the Kisesa observational HIV cohort study between 2006 and 2016 were eligible for inclusion. Survival analysis was used to calculate person-time at risk, incidence rates and 95% confidence intervals (CIs). Cox regression models were used for the risk factor analyses disaggregated by sex and age group. Results The HIV prevalence in the sero-surveys decreased from 7.2% in 2006/07 to 6.6% in 2016, with a notable decrease of over 50% for both men and women aged 15–24 years. The incidence rate for HIV was estimated to be 5.5 (95% CI 4.6–6.6) per 1,000 person-years in women compared to 4.6 (95% CI 3.5–5.8) in men, with a decrease over time. Despite the availability of ART services, the uptake is still small. Conclusions New infections are still occurring, with high HIV incidence in individuals aged below 45 years. With new guidelines and the 95-95-95 UNAIDS target, prevalence and incidence must be adequately assessed. In addition, there is a need for additional efforts to assess the impact of HIV/AIDS prevention programmes and intervention services, especially in these areas where resources are limited.
Congenital cytomegalovirus infection after maternal primary infection in a patient with systemic lupus erythematosus: A case report and literature review
Authors: Nakamura Eri , Isoda Kentaro , Kotani Takuya , Hiramatsu Yuri , Wada Yumiko , Fujiki Youhei , Fujita Daisuke , Takeuchi Tohru 
Published: January 2022

Background Management of infectious complications in pregnant women receiving immunosuppressive therapy for systemic lupus erythematosus (SLE) is important. Maternal infection with cytomegalovirus (CMV) often causes congenital CMV infection in the foetus. Thus far, there are only few reports on congenital CMV infection after maternal reactivation in patients with SLE. We report the first case of congenital CMV infection after maternal primary infection in a patient with SLE. Case presentation A 19-year-old Japanese primigravida with SLE received treatment with prednisolone 3 mg/day and azathioprine 75 mg/day at conception. At 7 weeks of gestation, she suddenly developed fever and had decreased white blood cell and platelet counts and elevated aspartate aminotransferase and alanine aminotransferase levels. These clinical findings led to a diagnosis of SLE exacerbation. The prednisolone dose was increased to 15 mg/day, and hydroxychloroquine (200 mg/day) was administered. Consequently, all clinical findings normalised at 12 weeks. At 19 weeks, foetal ultrasound findings revealed oligohydramnios, brain hypoplasia, ventriculomegaly and hyperechogenic bowel. Maternal serological test results indicated increased CMV-specific IgG and IgM levels, low IgG avidity (26%), and positive CMV antigenemia. The foetus was diagnosed with symptomatic congenital CMV infection transmitted from the maternal primary infection. After counselling about the severe prognosis of the foetus, the mother decided to terminate her pregnancy and underwent artificial abortion at 21 weeks. Discussion The foetus of a mother with SLE who is receiving immunosuppressive therapy may be at increased risk of transmission and aggravation of congenital CMV infection; thus, preventive management and screening for congenital CMV infection during pregnancy are recommended for such patients. Maternal CMV infection shows clinical findings similar to those of SLE exacerbation, and careful differential diagnosis by maternal serological evaluation and foetal ultrasound scans is required.
Challenging the entrepreneurial discourse around women home-based workers’ empowerment
Authors: Huq Afreen , Delaney Annie , Debney Ben 
Published: January 2022

AbstractThis article explores dominant entrepreneurship discourse and practice surrounding informal women home-based workers, and their relationship to goals of individual empowerment. We argue that conventional neoliberal entrepreneurship discourse conflates empowerment and performativity, linking the capacity of women to develop greater agency with their incorporation into an economic regime with predetermined roles, labelled ‘empowerment’. Applying a critical lens, we analyse the development discourse on entrepreneurship and economic performativity in these terms – looking to understand the characteristics of empowerment concerning home-based workers in Bangladesh working for a fair-trade organisation and a domestic garment supply chain. We argue that the conflation of empowerment and performativity serves the convenience of neoliberal ideology rather than the empowerment needs of those to whom such discourses are applied. To complement our critique, based on the empowerment literature, we develop a conceptual framework of empowerment and agency encompassing individual and collective agency, considering these in light of the relationship between performativity and social reproduction. Coupling a more nuanced understanding of empowerment to the critique of the entrepreneurial discourse, as applied to women home-based workers, provides a theoretical contribution to the empowerment and entrepreneurial discourse literature.
Countries Manufacturing Pharmaceuticals for the US Market: A 10-Year Analysis of Public Data
Authors: Hatton Randy C. , Leighton Greg , Englander Libbe 
Published: January 2022

Background: Concerns about strategic supplies and quality have increased the scrutiny of the countries where US pharmaceuticals are made. Objective: To examine the locations of manufacturers of brand name, biological, and generic drugs over 10 years. Methods: This longitudinal descriptive study used publicly available data from US government Web sites, including the Food and Drug Administration (FDA) Drug Establishments list, FDA National Drug Code Directory, FDA Orange Book, FDA Purple Book, and the National Institutes of Health DailyMed Drug Labels. These data were collected from 2011 to 2020. Results: Brand name drug manufacturing in the United States and Europe decreased from 89% in 2011 to 79% in 2020. Biological manufacturing in the United States decreased, while that in Western European countries increased; 100% of biological manufacturing was done in the United States or Europe in 2011 and decreased to 93% by 2020. Generic manufacturing in India increased from 21% to 51%, while US manufacturing decreased from 52% to 35% from 2011 to 2020. These analyses were limited to publicly available data, and the results could be affected by the accuracy and completeness of the data. Conclusions and relevance: Brand name drugs and biologicals are primarily made in the United States and Europe. Generic drugs are increasingly made in India, but the United States remains a major supplier. If the country of origin for pharmaceuticals is important, these findings support supply chain concerns for generic drugs. We recommend that product containers and official labeling prominently include the manufacturer and location for active pharmaceutical ingredients and finished dosage forms.
Ado-trastuzumab emtansine associated spider telangiectasia
Authors: Gursoy Pınar , Acar Ayda , Acikalin Taner 
Published: January 2022

Introduction Breast cancer is the most common cancer in women. Human epidermal growth factor receptor 2 (HER2) positivity rate is 20% and generally has a poor prognosis. Ado-trastuzumab emtansine (T-DM1) is an antibody–drug conjugate consisting of HER2 target monoclonal antibody trastuzumab and microtubule inhibitor emtansine. The most common side effects are fatigue, diarrhea, anemia, and it is generally a safe and tolerable agent. Case report In our case, we reported our patient who developed mucosal and cutaneous telangiectasia after T-DM1 treatment and who had a complete response in metastases after skin lesions. Management and Outcome While no side effects were observed during the use of T-DM1 for HER2 positive disease, nose bleeding and spider telangiectasia on the skin developed in the 9th month of the treatment. In these lesions, which did not require any treatment, no regression was observed during T-DM1 treatment. Discussion We think that T-DM1, which was detected with a low incidence of skin toxicity in studies, may form telangiectatic lesions due to vascular dilatation through emtansine, and therefore care should be taken in the treatment of T-DM1.
Bilateral lipid keratopathy with rheumatic fever in siblings
Authors: Richa Dhiman , Meena Lakshmipathy , Jyotirmay Biswas 
Published: January 2022

Purpose To report two unusual cases of lipid keratopathy in siblings with rheumatic fever and positive anti-phospholipid antibodies. Methods Clinical and histopathological examination along with complete systemic work-up was done after taking appropriate consent from the patients. A serum lipid profile showed elevated cholesterol and low-density lipoproteins. Systemic history revealed both the siblings were on treatment for rheumatic fever. A complete blood profile showed positive anti-phospholipid antibodies in one of them. Results Penetrating keratoplasty was performed in both cases one year apart. Histopathological examination showed lipid filled macrophages distributed throughout the corneal stroma. No episode of recurrence was noted in the follow-up period of three years. Conclusion These two cases highlight the importance of a thorough family history and a full systemic work-up in a patient with bilateral symmetrical lipid keratopathy. The co-existence of rheumatic fever and anti-phospholipid syndrome has been studied in literature but, their presence along with lipid keratopathy has not been previously described. It requires further research whether they have an association or it was just an incidental finding.
Analysis of preplatelets and their barbell platelet derivatives by imaging flow cytometry
Authors: Kemble Samuel , Dalby Amanda , Lowe Gillian C. , Nicolson Phillip L. R. , Watson Steve P. , Senis Yotis , Thomas Steven G. , Harrison Paul 
Published: January 2022

Abstract
Circulating large “preplatelets” undergo fission via barbell platelet intermediates into two smaller, mature platelets. In this study, we determine whether preplatelets and/or barbells are equivalent to reticulated/immature platelets by using ImageStream flow cytometry and super-resolution microscopy. Immature platelets, preplatelets, and barbells were quantified in healthy and thrombocytopenic mice, healthy human volunteers, and patients with immune thrombocytopenia or undergoing chemotherapy. Preplatelets and barbells were 1.9% ± 0.18%/1.7% ± 0.48% (n = 6) and 3.3% ± 1.6%/0.5% ± 0.27% (n = 12) of total platelet counts in murine and human whole blood, respectively. Both preplatelets and barbells exhibited high expression of major histocompatibility complex class I with high thiazole orange and Mitotracker fluorescence. Tracking dye experiments confirmed that preplatelets transform into barbells and undergo fission ex vivo to increase platelet counts, with dependence on the cytoskeleton and normal mitochondrial respiration. Samples from antibody-induced thrombocytopenia in mice and patients with immune thrombocytopenia had increased levels of both preplatelets and barbells correlating with immature platelet levels. Furthermore, barbells were absent after chemotherapy in patients. In mice, in vivo biotinylation confirmed that barbells, but not all large platelets, were immature. This study demonstrates that a subpopulation of large platelets are immature preplatelets that can transform into barbells and undergo fission during maturation.
Using machine learning to detect the differential usage of novel gene isoforms
Authors: Zhang Xiaopu , Hassan Musa A. , Prendergast James G. D. 
Published: January 2022

Abstract
Background
Differential isoform usage is an important driver of inter-individual phenotypic diversity and is linked to various diseases and traits. However, accurately detecting the differential usage of different gene transcripts between groups can be difficult, in particular in less well annotated genomes where the spectrum of transcript isoforms is largely unknown.

Results
We investigated whether machine learning approaches can detect differential isoform usage based purely on the distribution of reads across a gene region. We illustrate that gradient boosting and elastic net approaches can successfully identify large numbers of genes showing potential differential isoform usage between Europeans and Africans, that are enriched among relevant biological pathways and significantly overlap those identified by previous approaches. We demonstrate that diversity at the 3′ and 5′ ends of genes are primary drivers of these differences between populations.

Conclusion
Machine learning methods can effectively detect differential isoform usage from read fraction data, and can provide novel insights into the biological differences between groups.
Stroke in Middle Eastern children with cancer: prevalence and risk factors
Authors: Zadeh Catherina , AlArab Natally , Muwakkit Samar , Atweh Lamya A. , Tamim Hani , Makki Maha , Salhab Hamza A. , Hourani Roula 
Published: January 2022

Abstract
Objective
To determine the prevalence and to characterize the different types of strokes in children with cancer at the Children’s Cancer Center of Lebanon (CCCL), in addition to assess the factors and clinical findings leading to stroke in children.

Methods
We retrospectively reviewed the medical records and brain images (MRIs and CTs) of children admitted to the CCCL and diagnosed with cancer between years 2008 and 2017. Brain images were reviewed for the strokes’ onset, size, location, possible origin, its recurrence and type: intracranial hemorrhage (ICH), acute arterial ischemic stroke, and cerebral sinus venous thrombosis (CSVT) with and without venous infarct. Medical charts of the patients were reviewed for age, sex, their type of cancer, the treatment protocol they followed, and abnormal findings on their laboratory studies and neurological exams.

Results
Out of the 905 charts reviewed, twenty-seven children with variable types of cancer had strokes, with a prevalence of 2.9%. Their median age at cancer diagnosis was 9.4 (4.8-13.7) years and the median age at stroke onset was 10.6 (6.7-15.5) years. The median time between the cancer diagnosis and the stroke episode was 6 months. CSVT cases were the most common (60%) followed by acute arterial ischemic (22%) and hemorrhagic strokes (18%), with CSVT being the latest to occur. We observed that the different types of strokes were related to some types of cancer. Of the children that had acute arterial ischemic stroke in this cohort, 83% had brain tumors, of the children who had CSVT, 87.5% had leukemia, and of the children who had hemorrhagic stroke, 40% had leukemia. Neurological abnormalities were more prevalent in acute arterial ischemic stroke (80%). Patients with CSVT recovered better than those with other types of strokes. Strokes recurred in 60% of ischemic strokes. L-Asparaginase was significantly associated with CSVT.

Conclusions
The prevalence of strokes was 2.9% in children with cancer. We were able to identify factors related to the types of the stroke that occurred in children including the type and location of the cancer the type of treatment received, and stroke recurrence.