bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of RUNX2 and HMGB1 expression as markers of tumor aggressiveness in urothelial carcinoma
Authors: Ibrahim Doaa A. , Abdelrahman Doaa I. 
Published: November 2022

Aim
To investigate the expression and the clinical significance of runt-related transcription factor (RUNX2) and high-mobility group box 1 (HMGB1) in urothelial carcinoma of the urinary bladder. The correlation between RUNX2 and HMGB1 expression and the clinicopathological features was analyzed.

Patients and methods
RUNX2 and HMGB1 expression was examined by immunohistochemistry in 62 urothelial carcinoma and 20 nonneoplastic bladder tissues as control group.

Results
High RUNX2 and HMGB1 protein expression was observed in 67.7 and 56.5% of cases of urothelial carcinoma, respectively, and showed predominantly nuclear expression. The expression of RUNX2 and HMGB1 in urothelial carcinoma was significantly higher than that in nonneoplastic urothelial tissues (P<0.001 for each). Moreover, high RUNX2 expression was significantly associated with high tumor grade (P=0.003), advanced tumor stage (P=0.011), lymph-node metastasis (P=0.045), and the presence of concomitant carcinoma in situ (P=0.01). HMGB1 showed higher expression with high-grade tumors (P=0.007), advanced tumor stage (P=0.002), and the presence of necrosis (P<0.001). A significant direct relationship was detected between RUNX2 and HMGB1 expression (P<0.001).

Conclusion
Our data suggest that RUNX2 and HMGB1 overexpression may contribute to urothelial carcinoma tumorigenesis and was associated with aggressive clinicopathologic features. RUNX2 and HMGB1 could be promising potential biomarkers for urothelial carcinoma.
Exceptional behavior of breast cancer-associated type 1 gene in breast invasive carcinoma
Authors: Abbas Zafar , Nouroz Faisal , Ejaz Samina 
Published: November 2022

Background:
Cellular expression level of Breast Cancer-Associated Type 1 (BRCA1) encoded protein is the sign of genome integrity, stability, and surveillance. BRCA1 after sensing DNA damage activates repairing system and if mutated leaves genomic lesions unrepaired and triggers transformation of normal breast cells into cancerous ones.

Aims of study:
We conducted in silico study to have a holistic view of BRCA1's correlation with multiple variables of breast invasive carcinoma.

Materials and Methods:
We used user-friendly online GeneCardsSuite pathway-level enrichment analysis, UALCAN portal differential expression analysis, cBioPortal cancer genome platform for mutatome map construction, and cancer cell lines encyclopedia genomics of drug sensitivity toolkit to understand correlation of BRCA1 expression with the effectiveness of anti-cancer drugs.

Results:
Contrary to general behavior of a tumor suppressor gene our study revealed BRCA1 overexpression under all circumstances. This novel finding needs to be explored further to understand functional impact of BRCA1 overexpression on the expression of many genes which are transcriptionally regulated by BRCA1 and promotion of tumriogenesis.

Conclusion:
Our study highlights the potential role of BRCA1-regulated genes in oncogenesis and recommends use of BRCA1-linked genes as future therapeutic targets for effective disease management.
Evaluation of clinically significant prostate cancer using biparametric magnetic resonance imaging
Authors: Mahajan Manik , Gupta Vikrant , Gupta Puneet , Sharma Poonam , Abrol Deepak 
Published: November 2022

Background:
Multiparametric magnetic resonance imaging (mp-MRI) of prostate involves a combination of T2-weighted imaging, diffusion-weighted imaging, and dynamic contrast-enhanced (DCE) scans. However, controversy exists in the literature regarding the true value of DCE in the detection of clinically significant (CS) prostate cancer (PCa).

Aim:
The aim of this study is to compare the role of biparametric MRI (bp-MRI) and mp-MRI in the detection of CS PCa.

Materials and Methods:
Thirty-six patients with raised serum prostate-specific antigen levels were included. Bp-MRI was performed in all patients, whereas mp-MRI was performed in 30 cases only. The findings were characterized on the basis of prostate imaging reporting and data system (PI-RADS) v2 grading. PI-RADS v2 score of 3 or more was considered CS PCa. All patients underwent transrectal ultrasound-guided biopsy. Gleason score >6 was considered CS. Statistical analysis was done using the SPSS software and results interpreted.

Results:
CS PCa was observed in 31 cases on histopathology. On bp-MRI, CS PCa was seen in 31 patients. Five cases of PI-RADS v2 score 3 were seen on bp-MRI and 3 of them were upgraded to PI-RADS 4 on DCE images. One case of PI-RADS 3 had low Gleason score on biopsy, whereas 1 case of PI-RADS 2 had CS PCa on biopsy. No significant difference was observed between bp-MRI and mp-MRI in the detection of CS PCa.

Conclusions:
Both bp-MRI and mp-MRI have high sensitivity, specificity, and diagnostic accuracy and were nearly identical in the detection of CS PCa with no significant advantage of DCE images.
Immune checkpoint inhibitors as neoadjuvant therapy in early triple-negative breast cancer
Authors: Mittal Niti , Singh Surjit , Mittal Rakesh , Kaushal Jyoti , Kaushal Vivek 
Published: November 2022

Context:
Immune checkpoint inhibitors combined with chemotherapy are being evaluated in neoadjuvant settings in early triple-negative breast cancer (TNBC).

Aim:
To evaluate efficacy and safety of checkpoint inhibitors in early TNBC.

Methods:
Electronic search was done using PubMed, EMBASE, Google Scholar, Cochrane Central Register of Controlled Trials and clinicaltrials.gov to identify relevant articles till October 31, 2020. Clinical trials evaluating checkpoint inhibitors as neoadjuvant therapy in early-stage TNBC were included. Outcomes assessed included pathologic complete response (pCR), event-free survival (EFS), and safety.

Statistical Analysis Used:
Meta-analysis was conducted using Cochrane review manager (RevMan) version 5.4. Randomized controlled trials (RCTs) were assessed for quality using Cochrane Collaboration risk of the bias assessment tool, version 2.0 (ROB-2). GRADE analysis was done to assess the overall quality of evidence for all outcomes.

Results:
Out of 116 studies screened, 5 RCTs were included in meta-analysis. Compared to control group, programmed death-1 (PD-1)/programmed death-ligand 1 (PDL-1) inhibitor group was associated with significant increase in rate of pCR (odd ratio [OR] =1.71 [1.38–2.11]; P < 0.00001) and EFS (1.77 [1.21–2.60]; P = 0.003). There was a significant increase in risk of serious adverse events (risk ratio [RR] =1.53 [1.28-1.83]; P < 0.00001), adverse events of special interest (AESI) of any grade (RR: 1.5 [1.34–1.69], P < 0.00001) and grade 3 or higher AESI (RR: 2.8 [1.87–4.19], P < 0.00001) with PD-1/PDL-1 inhibitors compared to control.

Conclusions:
PD-1/PDL-1 inhibitors in combination with neoadjuvant chemotherapy for early TNBC show significant improvement in pCR irrespective of PDL-1 status and cancer stage.
Impact of Health Education on Knowledge, Attitude and Practices Regarding Hand-Hygiene amongst School Children aged 10-12 Years in Pune: An Interventional Study
Authors: Kothari Akshay , Phutane Vivek S , Bajaj Swati , Mukherjee Reema , Tawar Shabeena 
Published: November 2022

Background:
Hand hygiene in school children is a widely recognized low-cost effective intervention for the prevention and control of many infectious diseases. Health and hygiene education in schools is now a part of the “Swachh Bharat Abhiyan” and is being implemented across most schools in India.

Objectives:
This study was carried out to assess the impact of intervention in the form of a health education package on change in knowledge, attitude, and practices (KAP) regarding hand hygiene among school children.

Methodology:
A prepost interventional study was carried out in a school located in an urban area of Pune, Maharashtra, to evaluate the effectiveness of health education intervention on KAP regarding hand hygiene among school children. A total of 115 children in the age group 10–12 years were included in the study. The baseline KAP was measured using a pretested validated questionnaire followed by intervention in the form of health education through health talks, interactive sessions, videos, and demonstrations. Postintervention assessment of KAP was done using the same questionnaire.

Results:
The mean age (± Standard Deviation) of the study participants was 11.2 (±-0.712) years. Boys comprised 65.2% of the study population and the remaining 34.8% were girls. The baseline survey showed that only 3.5% of school children were aware of the correct method of handwashing which improved significantly to 91% postintervention. None of the children knew the names of the diseases prevented by handwashing preintervention. This changed postintervention, where 27.8% said it prevents diarrheal diseases, 20.0% said it prevents common cold, and 52.2% said it prevents both. The practices regarding handwashing before eating meals at home, after using toilet facility, after coughing/sneezing, and after playing outside improved significantly postintervention.

Conclusion:
Health education is an effective intervention to improve hand-washing practices among school children and bring about behavioral change for disease prevention.
CONTRIBUIÇÕES DA FILOSOFIA NA IMANÊNCIA PARA A EDUCAÇÃO E PARA OS ESTUDOS DECOLONIAIS*
Authors: Vilar de Carvalho André Martins 
Published: November 2022

Confrontando as ideações metafísicas, que pressupõem um ideal, moralmente justificado de bondade, beleza e justiça, a que todos deveriam perseguir, este artigo propõe a compreensão do ser humano e de suas práticas, incluindo a educação, a partir da filosofia da imanência, ou seja, da admissão do mundo sensível como o único existente e de nossos afetos como guias confiáveis e incontornáveis na nossa relação conosco mesmos, com o outro e com o mundo. Nesse sentido, ao invés de tentar modelar as crianças segundo um ideal de racionalidade, imposto de forma colonial, a educação pode convidá-las a uma compreensão do mundo a partir dos seus próprios afetos, ajudando-as a expressarem criativamente o seu self e a caminharem no sentido de construírem modos de existência baseados na ética, entendida como a potência de pensar no outro a partir da compreensão de si mesmo.
Pengaruh Pertumbuhan Perusahaan, Ukuran Perusahaan Dan Likuiditas Terhadap Nilai Perusahaan Dengan Kebijakan Hutang Sebagai Variabel Moderasi
Authors: Widarnaka Widarnaka , Sunardi Nardi , Holiawati Holiawati 
Published: November 2022

Pesatnya perkembangan pasar saham mengakibatkan investor semakin berhati-hati dalam memilih perusahaan untuk berinvestasi. Tujuan penelitian ini adalah untuk mengetahui pengaruh pertumbuhan Perusahaan, Ukuran Perusahaan dan Likuiditas Terhadap Nilai Perusahaan Dengan Kebijakan Hutang Sebagai Variabel Moderating pada Perusahaan Otomotif dan Komponen Yang Terdaftar di Bursa Efek Indonesia. Metode dalam penelitian ini adalah kuantitaf Asosiatif. Pengambilan sampel dilakukan menggunakan metode purposive sampling. Penelitian ini menggunakan analisis regresi linear berganda, uji hipotesis (uji t statistik dan uji koefisien determinasi) dengan menggunakan program Eviews 10.0. Hasil penelitian menunjukkan bahwa secara parsial variabel pertumbuhan perusahaan tidak berpengaruh dan signifikan terhadap nilai perusahaan. Ukuran Perusahaan tidak berpengaruh terhadap nilai perusahaan. Likuiditas berpengaruh dan signifikan terhadap nilai perusahaan. Hasil moderasi Kebijakan Hutang memperlemah pengaruh Pertumbuhan Perusahaan terhadap nilai perusahaan. Hasil moderasi Kebijakan Hutang memperkuat pengaruh ukuran perusahaan terhadap nilai perusahaan. Hasil moderasi kebijakan hutang memperlemah pengaruh Likuiditas terhadap nilai perusahaan. Hasil penelitian menunjukkan secara simultan pertumbuhan perusahaan, ukuran perusahaan dan likuiditas memiliki pengaruh signifikan terhadap nilai perusahaan.
ANTICOAGULANT TREATMENT AT A SPECIALIZED OUTPATIENT ANTICOAGULATION SERVICE, A DESCRIPTIVE STUDY
Authors: Khan Siddra Ahmed , Shah Saeed Ullah , Saleem Muhammad Asad Ali , Hassan Yusuf , Khan Asaad Akbar , Jan Kashif , Azeem Muhammad Abdul , Mahmood Hira 
Published: November 2022

Objectives: ACR (Anticoagulation registry aims to record information about the health status of their registered patients and the health care they receive over varying periods for a particular disease requiring anticoagulation. (e.g., Warfarin, Novel Oral Anticoagulants, and Parenteral Heparins). It’s the male and female prevalence and the mean age the patients are presenting in. Further, to foresee the development of a nationwide Anticoagulation network which will provide a nidus for developing specific disease-based registries.
Methodology: A retrospective observational study of 1695 registered patients in the ACR since 2018. The registered patient’s data was analyzed using SPSS version 23.0. Variables so far defined and analyzed were demographic distribution, gender, age, indications for anticoagulation.
Results: There were 799 (47.1%) female and 896 (52.86%) male patients requiring anticoagulation with a mean age of (54.37 +/- 17.79 SD) years. The primary indication for anticoagulation in our registry was Thrombosis and Thromboembolism 787/1695 patients (34.90%), Cardiac prosthesis 540/1695 patients (24.06%), Atrial Fibrillation and Atrial Flutter 486 patients (21.50%). 266/1695 (11.81%) are in the registry as they have Rheumatic Heart disease requiring anticoagulation .55/1695 (2.44%) of patients are registered with us due to Intra-cardiac devices implantation requiring anticoagulation—the remaining anticoagulation needed due to other reasons, which were cardiac and non-cardiac as well. The proportion of females with atrial fibrillation was significantly higher than male patients, 33.6% vs. 24.5% (p=0.000). Moreover, in Age distribution, most patients are between 61 years to 70 years of age. Geographically most of the patients are from the Punjab Province.
Conclusion: ACR annual report will allow healthcare professionals to see which disease requiring anticoagulation is prevalent in our setup. It illustrates different approaches to anticoagulation therapy. Registry further informs how the patients responded to anticoagulation, the safety with which the anticoagulation was terminated after treatment of the disease in short-duration anticoagulation cases, and the outcome of patients in lifelong anticoagulation cases. Currently, we are working on how to store the data on the disease-specified target range. This will help us establish the importance of ACR in anticoagulation management.
FREQUENCY OF HYPERTHYROIDISM IN PATIENTS PRESENTING WITH ATRIAL FIBRILLATION TO CARDIOLOGY UNIT KHYBER TEACHING HOSPITAL PESHAWAR
Authors: Ullah Shafi , Ahmad Asfandyar , Akhtar Shakeel , Shah S. Sadiq , Ashraf Amber 
Published: November 2022

Objectives: Hyperthyroidism can occur in 9–15% of patients having atrial fibrillation (AF, a-fib). Decreased level of serum thyrotropin in blood is a distinct threat for a-fib. Two-third of patients can convert into sinus rhythm with proper treatment of hyperthyroidism. Beta-blockers can be helpful in reducing left ventricular hypertrophy and atrio-ventricular arrhythmia in individuals having hyperthyroidism. Treating hyperthyroidism is a bit controversial. Thyroxine dose needs adjustment in those patients on replacement therapy and beta-blocker is also valuable in extrinsic hyperthyroidism. To determine frequency of hyperthyroidism in patients with Atrial fibrillation.
Methodology: This descriptive cross-sectional study was conducted at Cardiology unit (OPD and In-patients), Khyber Teaching Hospital, Peshawar From Nov 17, 2019 to May 16, 2020. A sample size of 179 patients, having presentation of atrial fibrillation were enrolled in the study. All individuals having AF, confirmed by ECG, were advised to do thyroid function test and those with hyperthyroidism were enrolled.
Results: In our sample size 108 (60.34%) were males and 71(39.66%) were females. Male vs. female ratio was 1.6:1. Subjects in this study were having an average age of 46.16years + 9.51 SD with range of 25-60 years. Subjects ages were classified into three groups, among which most common age group for atrial fibrillation was more than 50 years. The hyperthyroidism was found in 14(7.82%) patients while 165(92.18%) patients were found free of hyperthyroidism.
Conclusion: We Hyperthyroidism is a recognized cause of atrial fibrillation. Every new onset atrial fibrillation should be investigated with serum TSH levels.
Logistics Innovation and Its Influence on Performance of Building and Construction Manufacturing Firms in Kenya
Authors: Gikonyo Peter Kiama , Ngugi Patrick Karanja , Paul Samson Nyang’au 
Published: November 2022

Purpose: The study sought to assess the influence of logistics innovation on the performance of building and construction manufacturing companies in Kenya. This comes at a time when the world is facing climatic challenges and dynamics attributed to increased environmentally unfriendly practices which lead to increased emissions and pollution to the environment. As the companies are called to practice eco-friendly operations, logistics remains one area of focus, where most global leaders are investing in to ensure sustainability is embraced. However, this has not been effectively assessed on a local context. The study sought to establish the key logistics innovations that manufacturing companies can embrace to enhance performance.
Methodology: The study adopted a descriptive research design approach. This method is preferred because it allows an in-depth study of the subject. The study population was 900 employees drawn from the 54 building and construction manufacturing firms in Kenya. The sample size was 270 respondents which was determined through purposive sampling targeting departments (production, quality assurance, procurement and supply chain, transport and logistics, and administration) in the 54 companies. Primary data was collected using a questionnaire. Quantitative data was analyzed through descriptive statistics and inferential statistics.
Findings: The results revealed that logistics innovation significantly influenced the performance of the building and construction manufacturing firms in Kenya. The study concluded that through embrace of green logistics through logistics innovation, performance of the manufacturing firms was obtained.
Unique Contribution to Theory, Policy and Practice: It is recommended that the management of the building and construction manufacturing firms embraces logistics innovation though use of solar technology, hybrid vehicles and tracks and reducing emissions in order to enhance sustainability and promote performance.
RESEARCH ON POLITICAL COMMUNICATION OF CHINESE MEDIA IN THE MEDIA CONVERGENCE ERA
Authors: XIE Wanying ,  Dr. JIANG Sheng , Dr Allauddin Kakar  
Published: November 2022

This study is a research paper of the third tutor academic leadership project in Shanghai International Studies University, 2018. Comparative Study on Sino-US Agenda Setting in Sino US Trade Friction. (Project No. 41003647)
In the media convergence era, the new media environment and political communication complement each other. With the characterization of multi-channel and multi-terminal, the pattern of political communication has been changed. Effective communication channels and technologies of political communication is provided by big data. Audiences could obtain political information timely and effectively. It is a practical problem for China to explore new ways of political communication and enhance political communication ability. This study mainly analyzes the developing status and characteristics of political communication of Chinese media in the media convergence era, discusses the problems and countermeasures in the process of media convergence and forecasts the future trends of political communication of Chinese media.
Pemurnian Minyak Sawit Merah Menggunakan Filter Bentonit dan Membran Keramik
Authors: Oktarianti Vina , Dewi Erwana , Junaidi Robert 
Published: November 2022

Minyak Sawit mentah (Crude Palm Oil) adalah minyak kasar yang diperoleh dengan cara ekstraksi daging buah sawit dan mempunyai karakter yang belum layak makan karena masih banyak mengandung kotoran terlarut dan tidak terlarut dalam minyak. Minyak sawit merah adalah minyak sawit yang diperoleh tanpa melalui proses pemucatan (bleaching) tujuannya mempertahankan kandungan karotenoidnya. Membran keramik dapat menjadi salah satu alternatif media filter untuk pengolahan minyak sawit khususnya minyak sawit merah. Tujuan dari penelitian ini adalah untuk mengetahui dan melakukan inovasi proses dalam pemurnian MSM menggunakan filter bentonit dan membran keramik serta mengetahui karakteristik produk minyak sawit merah yang dihasilkan. Proses pemurnian dengan filter terdiri dari bentonit , membran keramik, dan cartridge dilakukan pada tekanan 5 bar dengan variasi suhu 50oC, 60oC, 70oC dengan waktu penampungan permeat tiap 2 menit. Hasil penelitian didapatkan nilai fluks tertinggi pada suhu 50oC yaitu 54,420 L/m2.jam. Membran keramik ini mampu merejeksi kandungan ?-karoten sebesar 27,140 % sedangkan rejeksi asam lemak bebas tertinggi sebesar 2,627%. Produk terbaik minyak sawit merah yang dihasilkan memiliki densitas 0,9263 g/ml, viskositas 15,54 cp, kadar air 0,020%, ALB 6,099%, bilangan peroksida 5,984 mEk/kg dan ?-karoten 766,057 ppm. Namun produk yang dihasilkan masih belum memenuhi standar MSM yang dijual dipasaran karena kandungan yang terdapat didalam produk minyak sawit merah masih tinggi terutama pada kandungan asam lemak bebas dan bilangan peroksida.
Arquitetura de um ambiente para a Associação de Apoio aos Portadores de Câncer de Mossoró e Região (AAPCMR)
Authors: Santos Lanuza , Sousa Reudismam Rolim de , Silva José Wagner Cavalcanti 
Published: November 2022

A Associação de Apoio aos Portadores de Câncer de Mossoró e Região (AAPCMR) é uma entidade sem fins lucrativos que tem como missão prestar assistência social e amparo ao paciente com câncer, a fim de facultar ao paciente e seu acompanhante, com hospedagem digna e apoiando com ações sociais como cesta básica, fisioterapia e tratamento odontológico. Nesse sentido, a casa de apoio necessita realizar o gerenciamento de suas unidades, para facilitar o atendimento aos pacientes e o controle dos processos. Atualmente, eles gerenciam a associação e suas funções através de ferramentas como o papel e planilha de texto. O principal objetivo deste artigo é propor um sistema que possibilite agilizar a gerência das ações exercidas pelo núcleo de apoio.
PERBANDINGAN PERTUMBUHAN JAMUR Candida albicans PADA MEDIA ALAMI JAGUNG, SINGKONG DAN UBI JALAR KUNING
Authors: Nur Safitri Atika , Qurrohman Muhammad Taufiq 
Published: November 2022

Diagnosis laboratorium kandidiasis dapat dilakukan dengan cara melakukan pemeriksaan mikroskopis, identifikasi molekuler, uji serologi dan sistem kultur terhadap spesimen. Pada metode kultur penyakit kandidiasis dilakukan dengan mengisolasi jamur Candida albicans dari sampel pasien pada media. Beberapa peneliti terdahulu berhasil menemukan media alami pertumbuhan jamur Candida albicans. Penelitian yang dilakukan adalah eksperimental dengan menggunakan Rancangan Acak Lengkap (RAL) dengan 2 faktor perlakuan. Faktor 1 adalah jenis jamur yaitu Candida albicans, faktor 2 adalah jenis media alami yaitu media dari jagung, singkong dan ubi jalar kuning dan media PDA sebagai kontrol. Pada pengamatan inkubasi 48 jam didapatkan pertumbuhan rata-rata koloni jamur Candida albicans sebanyak 4,27 pada media jagung, 5,87 pada media singkong, 5,70 pada media ubi jalar kuning dan 2,48 pada media PDA. Dari hasil uji Saphiro-wilk didapatkan bahwa data terdistribusi normal (p>0,05). Data hasil uji Levene Test didapatkan bahwa data diasumsikan sama (p>0,05), serta uji One Way ANOVA didapatkan bahwa (p<0,05) yang berarti terdapat perbedaan pertumbuhan jamur Candida albicans pada media jagung, singkong dan ubi jalar kuning.