bluuebunny/crossref_metadata_2025_split huggingface dataset:
The tribological property of a-C:H coating with tribolayer by additive having glycerol and phosphate oxide structure
Authors: Tokoroyama Takayuki , Tanaka Kento , Kani Takumi , Murashima Motoyuki , Lee Woo Young , Umehara Noritsugu , Oshio Tadashi , Yagishita Kazuhiro 
Published: July 2022

Abstract
The tribological properties of a-C:H coating sliding against a SUJ2 ball, a SUJ2 roller, and an a-C:H coated roller were investigated under temperatures ranging from 20°C to 80°C in PAO with different additives. The additives had a glycerol and hydroxyl functional group in one molecule to enhance additive adsorption for mating with the a-C:H coating disk material and to build a phosphorus oxide tribolayer. Additives with different numbers of hydroxyl groups and primary or secondary-type C6H13O structures were also prepared. The tribolayer derived from each additive was analyzed via EDS, XPS, and ToF-SIMS. XPS depth analysis for the tribolayers revealed that additives were dissociated by friction and suggested C–O bond cleavage occurred.
Photon-counting statistics-based support vector machine with multi-mode photon illumination for quantum imaging
Authors: Kim Jin-Woo , Cho Jeong-Sik , Sacarelo Christian , Fitri Nur Duwi Fat , Hwang Ju-Seong , Rhee June-Koo Kevin 
Published: July 2022

Abstract
We propose a photon-counting-statistics-based imaging process for quantum imaging where background photon noise can be distinguished and eliminated by photon mode estimation from the multi-mode Bose-Einstein distribution. Photon-counting statistics show multi-mode behavior in a practical, low-cost single-photon-level quantum imaging system with a short coherence time and a long measurement time interval. Different mode numbers in photon-counting probability distributions from single-photon illumination and background photon noisecan be classified by a machine learning technique such as a support vector machine (SVM). The proposed photon-counting statistics-based support vector machine (PSSVM) learns the difference in the photon-counting distribution of each pixel to distinguish between photons from the source and the background photon noise toimprove the image quality. We demonstrated quantum imaging of a binary-image object with photon illumination from a spontaneous parametric down-conversion (SPDC) source. The experiment results show that the PSSVM applied quantum image improves a peak signal-to-noise ratio (PSNR) gain of 2.89dB and a structural similarity index measure (SSIM) gain of 27.7% compared to the conventional direct single-photon imaging.
Extramedullary Acute Myeloid Leukemia in the De Novo Setting: Clinicopathologic Characteristics, Molecular Analysis, and Treatment Outcomes
Authors: Kuhlman Justin , McCormick Benjamin , Jiang Liuyan , Menke David , Badar Talha , KHARFAN-DABAJA Mohamed , Foran James , Rahman Zaid Abdel , Murthy Hemant 
Published: July 2022

Abstract
Extramedullary disease in acute myeloid leukemia (AML), also known as myeloid sarcoma (MS), is an uncommon presentation of de novo AML. We analyzed medical records of patients in the Mayo Clinic database spanning between 1996 and 2021 who were diagnosed with de novo extramedullary AML. Survival outcomes were analyzed using Kaplan-Meier and Cox-proportional hazard models for univariate and multivariate analysis, respectively. With a median follow-up of 20.7 months, 83 patients with de novo MS were identified; 49 presented with synchronous MS and 34 with isolated MS. Next generation sequencing (NGS) revealed RTK-RAS pathway mutations in 44% of patients. Median overall survival (OS) was 25.3 months and 17.8 months in isolated and synchronous MS, respectively (p = 0.49). Variables associated with improved OS on univariate analysis included treatment with intensive chemotherapy (p < 0.001), normal or favorable risk karyotype (p = 0.001), age less than 60 years (p = 0.001), and a complete response to treatment at extramedullary sites (p < 0.0001). On multivariate analysis, normal or favorable risk karyotype (p = 0.001), age less than 60 (p = 0.01), and a complete extramedullary response (p = 0.001) were associated with improved OS. Localized therapy did not provide added survival benefit in isolated MS. Genomic stratification, age, and extramedullary site response are predictive of survival outcomes.
Novel Image Cryptosystem Based on New 2D Hyperchaotic Map and Dynamical Chaotic S-box
Authors: Wang Xingyuan , Zhou Shuang , Qiu Yuyu , Zhang Yingqian 
Published: July 2022

Abstract
Chaotic systems are widely used in image encryption due to their sensitivity to initial values. and many image encryption algorithms based on chaotic systems have been studied in the past few years. In order to obtain a simpler and faster encryption algorithm, this work firstly proposes a new two-dimensional discrete hyperchaotic map, which has a large chaotic interval and Lyapunov exponent, and then uses the map to generate two chaotic sequences, and use these sequences to generate three S-boxes, and combine them in pairs, and finally twelve S-boxes are obtained. Then, the elements of the plaintext image are grouped, each group of pixels is summed, and then modular operations are used to specify specific S-boxes. Next, each set of elements is bitwise XOR with the corresponding S-box. Finally, the cipher image is obtained by scrambling using chaotic signal. Experiments show that compared with some other encryption algorithms, the proposed S-box based encryption method has higher security, and it resists to common attack.
Structures, Electronic and Magnetic Properties of Transition Metal Inserted W6O18 Clusters
Authors: Zhao Zhen , Wu Zi-hao , Li Zhi 
Published: July 2022

Abstract
Structures, electronic and magnetic properties of transition metal (TM) inserted W6O18 clusters have been investigated by using first principles. The results reveal that the Ti@W6O18, Ni@W6O18, Zr@W6O18, Rh@W6O18, W@W6O18 and Ir@W6O18 clusters are more structurally stable than their neighbors. The V@W6O18, Fe@W6O18, Zn@W6O18, Y@W6O18, Nb@W6O18, Pd@W6O18, Lu@W6O18, Re@W6O18, Hg@W6O18 clusters are more chemically stable than their neighbors. The mount of charge transfer between TM atoms and pristine W6O18 clusters decreases with the increase of the subgroup number except for subgroup number is equal to 11 and 12. The TM(d) states of the 3d TM@W6O18 clusters start to make the main contributions to Fermi level except for the Cu@W6O18 and Zn@W6O18 clusters. The spin densities of TM (TM=Mn, Fe, Co, Mo, Tc, Ru, Rh and Ir) atoms of the TM@W6O18 clusters are maintained to some extent.
Serum SynCol as a new Biochemical Marker of Synovial Tissue Turnover in Patients with Rheumatoid Arthritis
Authors: Gineyts Evelyne , Millet Marjorie , Borel Olivier , Coutant Frédéric , Rousseau Jean-Charles , Chapurlat Roland , Marotte Hubert , Garnero Patrick 
Published: July 2022

Abstract
BackgroundRheumatoid arthritis (RA) is characterized by synovium inflammation leading to joint destruction. No sensitive serum biochemical marker of synovial tissue activity is currently available. The aims of this study were to develop a new sensitive serum biochemical marker of synovium turnover and evaluate its performance in patients with RA.Methods We developed an enzyme-linked immunosorbent assay to measure synovial collagen fragments in serum (SynCol) using an antibody recognizing a specific 11 amino acid sequence from the triple helical portion of human type III collagen. The specificity of the antibody was evaluated by competitive inhibition with several collagen-related peptides. Immunohistochemistry was performed to localize the SynCol fragments in RA synovium. Serum SynCol was measured in patients with RA (n=66, 73% women, mean age 62 years, median disease activity score 28 (DAS 28) 2.6) participating in randomized clinical trials and in sex and age matched healthy controls (n=70, 76% women, mean age 59 years). ResultsThe SynCol ELISA demonstrated adequate analytical performances. Competitive inhibition experiments showed that the antibody used in the ELISA recognizes a neoepitope resulting from the cleavage of type III collagen molecules and also the homologous sequences of type IV collagen, but does not cross-react with intact type III and IV collagens. Immunohistochemistry of synovial tissue from a RA subject showed staining of SynCol fragments in the lining layer where destructive fibroblasts are localized and around blood vessels which are rich in type IV collagen. SynCol staining co-localized with matrix metalloproteinase 9 (MMP-9) immunostaining. Serum SynCol levels were significantly increased in patients with RA compared to healthy controls (+ 247 %, p <0.0001). In RA patients, circulating SynCol levels correlated with DAS 28 (r=0.66, p <0.0001) and patients with active disease (DAS 28 > 3.2, n=20) had levels which were 888 % (p<0.0001) higher than in those with low activity (n=46). Conclusions The SynCol ELISA is a sensitive and precise assay measuring circulating type III and IV collagen degradation fragments originating from synovial tissue turnover. Serum SynCol levels are markedly increased in patients with RA, particularly in those with active disease. Trial Registration- Role of the ANS Dysregulation in the Persistence of Fatigue in Rheumatoid Arthritis Patients Treated with Anti-TNF (ANSRA) NCT02475486- Bone MicroArchitecture Abatacept (BMA2) NCT02675218- Impact of the Persistence of Inflammation at Doppler Ultrasound Level on the Structural Evolution of Erosion in Rheumatoid Arthritis Treated with Biotherapy. NCT02531061IRB for synovial tissue 2019-A02742-55 (Comité de Protection des Personnes Sud-Méditerranée I
Immune Checkpoint Blockade PD-1 Therapy for Primary Liver Cancer: Incidence and Influencing Factors of Thyroid Dysfunction
Authors: Wu Huili , Xiong Fang , Bao Xuli , Lu Jun 
Published: July 2022

Abstract
Objectives To investigate the incidence and influencing factors of thyroid dysfunction(TD) in patients with primary liver cancer(PLC) induced by PD-1 monoclonal antibodies. Methods Clinical data were collected from 195 PLC patients treated with PD-1. They were divided into TD group and normal thyroid function(NTF) group, and further divided into TD subgroups, the differences between groups and subgroups were analyzed.Results A total of 113 of 195 (57.9%) PLC patients developed TD. The positive rate of thyroid antibody (20.6% vs. 0%, P = 0.041) and the median value of TSH (6.20 vs. 2.16 mu / L, P = 0.000) in TD group were higher than those in NTF group. Ten patients (8.8%) had the CTCAE grade of TD above grade 3, of which 2 patients died of liver failure. There were 20 patients (17.7%) in hyperthyroidism group and 93 patients (82.3%) in hypothyroidism group. The decompensated cirrhosis in hyperthyroidism group was lower than that in hypothyroidism group (33.3% vs. 65.6%, P = 0.010), and the proportion of patients who had previously received surgical treatment was higher than that in hypothyroidism group (35.0% vs. 9.7%, P = 0.003); The proportion of clinical hyperthyroidism was higher than that of clinical hypothyroidism (70.0% vs. 31.2%, P = 0.001), the proportion of decompensated liver cirrhosis in clinical hyperthyroidism group was lower than that in clinical hypothyroidism group (23.1% vs. 68.0%, P = 0.022), and the proportion of previous or combined surgical resection was much higher than that in clinical hypothyroidism group (42.9% vs. 7.1%, P = 0.018); The proportion of decompensated cirrhosis in primary TD group was lower than that in secondary TD group (36.5% vs. 83.3%, P = 0.002), and the proportion of patients using antitumor targeted drugs was higher than that in secondary TD group (73.1% vs. 45.0%, P = 0.014).Conclusion Patients with PLC had high incidence of TD after receiving PD-1 treatment, and primary and subclinical hypothyroidism was the main manifestation type, which was related to the degree of disease and treatment.
Enhanced Removal of Pb 2+ From Aqueous Solution Using Modified Extracts From Food Processing Wastes: Design of Experiments
Authors: Okoebor Eboseremen Sunday , Anyaogu Ikechukwu Daniel , Menkiti Mathew Chukwudi , Ejikeme Paul Madus 
Published: July 2022

Abstract
In this paper, biosorption of lead from aqueous solution on chitosan and modified chitosan from crab shells was investigated. Batch experiments have been carried out to find the effect of various parameters such as pH, temperature, sorbent dosage, heavy metal concentration and contact time on the biosorption of lead using these prepared adsorbents. Response surface methodology (RSM) was employed to optimize the process parameters. Based on the central composite design, quadratic model was developed to correlate the process variables to the response. The most influential factor on each experimental design response was identified from the analysis of variance (ANOVA). The optimum conditions for the biosorption of lead were found to be as follows: pH:10, temperature: 55°C, sorbent dosage: 2 g, metal concentration: 50 mg/L and contact time: 150 min. At these optimized conditions the maximum removal of lead by the chitosan and modified chitosan were found to be 84.38% and 89.83% respectively. From the analysis, the model’s coefficient of determination (R2) of (0.84 and 0.87 respectively of chitosan and modified chitosan) and F-value of (14.01 and 17.25 respectively for chitosan and modified chitosan) obtained proved that the experimental design model is adequate and can be used to navigate the design space. The sorbents were characterized using Fourier Transform Infra-red (FTIR) spectroscopy, Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC) and X-Ray Diffraction (XRD) spectroscopy. Freundlich and Lineweaver-Burk isotherm model well expressed lead biosorption onto the studied sorbent. The metal biosorption onto the sorbents correlated well with pseudo-second-order kinetic model.
Retinal &amp; choroidal alterations in migraine patients compared to normal healthy controls
Authors: Conway Miriam Louise , Ctori Irene 
Published: July 2022

Abstract
Purpose: Migraine is an incapacitating neurovascular disorder which primarily affects the working age population. Researchers have postulated that the transient vascular alterations during each migraine attack, leads to ischemic damage in the eye which can be measured via optical coherence tomography (OCT). Methods: We recruited 29 volunteers: 13 migraineurs (mean age 28±8.8 years; 12 female and 1 male) and 16 age-matched controls (mean age 26.6±6.9; 9 female and 7 male). All individuals underwent a detailed ophthalmic examination by a qualified optometrist and a Migraine Disability Assessment (MIDAS test). The investigators were blind to the migraine diagnosis. Retinal Nerve Fibre Layer (RNFL) thickness, Retinal Thickness (RT), Ganglion Cell Complex (GCL), ranging from the inner-limiting membrane to the inner plexiform layer, and Choroidal Thickness (CT) were measured using the 3D OCT-1Maestro, Topcon, a Spectral Domain OCT (SD-OCT) device. Results: In the migraine population average RNFL was lower for several parameters however, results did not reach statistical significance. A significant decrease in the right eye inferior parafoveal ganglion cell layer in the migraine group of patients (mean = 25.15, SD = 4.08) compared to normal healthy controls (mean = 28.81, SD = 4.85; t = (27) = 2.17, p = 0.039) was documented. No other ganglion cell layer or choroidal thickness reached significance. No significant relationship between ocular thickness parameters and either MIDAS score, migraine duration or aura diagnosis was found.Conclusion: A significant decrease in the right inferior parafoveal ganglion cell layer for migraine patients was reported. All other parameters did not reach significance. This area of research would benefit from a systematic review and meta-analysis which includes the RNFL, GCL and choroidal thickness and examines the impact of migraine type and MIDAS score/grade is needed
Synthesis, spectroscopic and catalytic properties of FeO x /Al 2 O 3 nanopowders prepared by cw CO 2 laser vaporization
Authors: Baronskiy Mark G. , Kostyukov Anton I. , Zhuzhgov Aleksey V. , Zaitseva Nadezhda A. , Cherepanova Svetlana V. , Larina Tatyana V. , Snytnikov Valeriy N. 
Published: July 2022

Abstract
Nanostructured powders xFe/nano-Al2O3 with the Fe loading of x = 0,0–5,0 wt% were obtained using laser vaporization by a cw CO2 laser. XRF, XRD, HRTEM, PL and UV-vis DRS techniques were employed to investigate physicochemical, structural and optical properties of the synthesized nanopowders with the average particle size of 9 nm. Nanopowders xFe/nano-Al2O3 as model catalysts were tested in isobutane dehydrogenation reaction. The results obtained were compared with similar data for the xFe/γPb-Al2O3 systems synthesized by the conventional sol-gel method. According to XRD and UV-vis DRS data, in the series of xFe/nano-Al2O3 samples a great part of Fe3+ ions is in the disordered environment of subsurface layers of Al2O3 nanocrystallites predominantly in tetrahedral coordination. In distinction to samples of the xFe/γPb-Al2O3 series, in the case of nanostructured xFe/nano-Al2O3 powders the formation of Fe2O3 phase does not occur at any concentrations of iron or conditions of testing. The analysis of the PL spectra of xFe/nano-Al2O3 powders also showed the presence of surface sites of Fe3+ ions, which were not detected for xFe/γPb-Al2O3. Catalytic testing of the xFe/nano-Al2O3 series samples in isobutane dehydrogenation revealed the formation of the iron active sites that ensure catalytic activity of the samples. Differences in the catalytic properties of FeOx/Al2O3 samples obtained by the sol-gel method and laser vaporization are related to different states of Fe3+ ions. Thus, the xFe/nano-Al2O3 nanopowders in contrast to xFe/γPb-Al2O3 contain a large amount of active Fe3+ sites. These sites involved in the dehydrogenation reaction are present predominantly on the surface of the nanopowders.
Contemporary Patterns of Local Ablative Therapies for Prostate Cancer at United States Cancer Centers: Results from a National Registry
Authors: Cole Alexander , Koelker Mara , Labban Muhieddine , Frego Nicola , Meyer Christian P. , Salomon Georg , Lipsitz Stuart , Withington John , Moore Caroline , Tempany Clare , Tuncali Kemal , George Arvin , Kibel Adam , Trinh Quoc-Dien 
Published: July 2022

Abstract
BACKGROUND: Local ablative therapies, a partial-gland treatment for localized prostate cancer (PCa), offers targeted cancer treatment while minimizing side-effects. We aim to describe national-level patterns in its use for localized PCa in the United States (U.S.).METHODS:We retrospectively interrogated the hospital-based National Cancer Database (NCDB) for men with clinically localized PCa from 2010-2017. The main outcome was receipt of local tumor ablation with either cryo or laser-ablation, and other focal therapy including high-intensity focused ultrasound (HIFU). Patient level, hospital level, and demographic variables were collected. A mixed effects logistic regression analysis was utilized to identify covariates and predictors on the patient- and hospital-level. RESULTS: Overall, 11 278 patients received ablative therapy. Cryotherapy was performed in 8 883 (78.8%), laser ablation in 1 755 (15.6%), and other focal therapy (HIFU) in 640 (5.7%) cases. On the patient-level, intermediate-risk PCa patients were more likely to be treated with ablative therapy (OR 1.05, 95% CI 1.00 – 1.11, p=0.05) than low-risk PCa patients, as were men with Charlson Comorbidity Index >1 (OR 1.36, 95%CI 1.29 -1.43, p<0.01), men between 71-80 years (OR 3.70, 95%CI 3.43-3.99, p<0.01), men with Medicare insurance (OR 1.38, 95% 1.31-1.46, p<0.01), and an income <$47 999 (OR 1.16, 95% 1.06-1.21, p<0.01). On the hospital-level, local ablative therapy was less likely to be performed in academic/research facilities (OR 0.45, 95% CI 0.32-0.64, p<0.01), while hospitals with a high annual caseload were more likely to perform local ablative therapies (2nd quartile, OR 1.23, 95% CI 1.12-1.35, p<0.01). CONCLUSIONS: In this study, we report trends from 2010-2017, in utilization of local ablative therapies using a large national database of U.S. cancer centers. The technique is more commonly used in older men with comorbidities. The financial aspects of ablative therapy need to be addressed to avoid inequity in access to care.
Thermal pressure in the thermal equation of state for solid and a proposed substitute
Authors: Yan Jinyuan , Yang Shizhong 
Published: July 2022

Abstract
The thermal equation of state (TEOS) for solids is a mathematic model among pressure, temperature and density, and is essential for geophysical, geochemical, and other high P-T researches. However, in the last few decades, there has been a growing concern about the accuracy of the pressure scales of the calibrants, and efforts have been made to improve it by either introducing a reference standard or building new thermal pressure models. The existing thermal equation of state, P(V, T) = P(V, T0) + Pth(V, T), consists of an isothermal compression and an isochoric heating, while the thermal pressure is the pressure change in the isochoric heating. In this paper, we demonstrate that, for solids in a soft pressure medium in a diamond anvil cell, the thermal pressure can neither be determined from a single heating process, nor from the thermal pressure of its calibrant. To avoid the thermal pressure, we propose to replace the thermal pressure with a well-known thermal expansion model, and integrate it with the isothermal compression model to yields a Birch-Murnaghan-expansion TEOS model, called VPT TEOS. The predicted pressure of MgO and Au at ambient pressure from Birch-Murnaghan-expansion VPT TEOS model matches the experimental pressure of zero (0) GPa very well, while the pressure prediction from the approximated Anderson PVT TEOS exhibit a big deviation and a wrong trend.
Large-volume and deep brain imaging in rabbits and monkeys using COMPACT two-photon microscopy
Authors: Lu Yuqing , Wei Xiangzan , Li Wei , Wu Xujun , Chen Chao , Li Ge , Huang Zhongqiang , Li Yunfeng , Zhang Yu , Gan Wen-Biao 
Published: July 2022

Abstract
In vivo imaging has been widely used for investigating the structure and function of neurons typically located within ~800 μm below the cortical surface. Due to light scattering and absorption, it has been difficult to perform in-vivo imaging of neurons in deep cortical and subcortical regions of large animals with two-photon microscopy. Here, we combined a thin-wall quartz capillary with a GRIN lens attached to a prism for large-volume structural and calcium imaging of neurons located 2 mm below the surface of rabbit and monkey brains. The field of view was greatly expanded by rotating and changing the depth of the imaging probe inside a quartz capillary. Calcium imaging of layer 5/6 neurons in the rabbit motor cortex revealed differential activity of these neurons between quiet wakefulness and slow wave sleep. The method described here provides an important tool for studying the structure and function of neurons located deep in the brains of large animals.