bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk and safety profile of electronic nicotine delivery systems (ENDS): an umbrella review to inform ENDS health communication strategies
Authors: Asfar Taghrid , Jebai Rime , Li Wei , Oluwole Olusanya Joshua , Ferdous Tarana , Gautam Prem , Schmidt Michael , Noar Seth M , Lindblom Eric N , Eissenberg Thomas , Bursac Zoran , Vallone Donna , Maziak Wasim 
Published: September 2022

ObjectivesThis umbrella review aims to summarise the evidence about electronic nicotine delivery systems’ (ENDS) risk and safety health profile to inform ENDS health communication strategies.Data sources and study selectionSix databases were searched for systematic reviews presenting evidence on ENDS-related health effects. Ninety reviews divided into five categories were included: toxicity=20, health effects=40, role in smoking cessation=24, role in transition to combustible cigarettes (CCs)=13 and industry marketing claims=4.Data extractionFindings were synthesised in narrative summaries. Meta-analyses were conducted by study type when appropriate. Quality assessment was conducted using the Measurement Tool to Assess Systematic Reviews. The Institute of Medicine’s Levels of Evidence Framework was used to classify the evidence into high-level, moderate, limited-suggestive and limited-not-conclusive.Data synthesisWe found high-level evidence that ENDS exposes users to toxic substances; increases the risk of respiratory disease; leads to nicotine dependence; causes serious injuries due to explosion or poisoning; increases smoking cessation in clinical trials but not in observational studies; increases CC initiation; and exposure to ENDS marketing increases its use/intention to use. Evidence was moderate for ENDS association with mental health and substance use, limited-suggestive for cardiovascular, and limited-not-conclusive for cancer, ear, ocular and oral diseases, and pregnancy outcomes.ConclusionsAs evidence is accumulating, ENDS communication can focus on high-level evidence on ENDS association with toxicity, nicotine addiction, respiratory disease, ENDS-specific harm (explosion, poisoning) and anti-ENDS industry sentiment. Direct comparison between the harm of CCs and ENDS should be avoided.PROSPERO registration numberCRD42021241630.
Solution for Simple Classical Systems Using SCILAB
Authors: Kumar Naik Bikash 
Published: September 2022

The use of computers as a learning tool has been a time-tested method, which can attract the interest and motivation of students to solve any complicated system easily. Scilab is an open-source computational software package that provides various tools to simulate and solve problems in classical mechanics. In this paper, two types of classical mechanics problems are solved. Under kinematics section, we solve the Projectile motion considering air resistance and particle falling under the action of gravity, with resistive force dependence on different exponents of velocity. Similarly, under the waves superposition section, we solve the two sinusoidal waves superimposed to give a Lissajous pattern and superposition of two or more waves using Scilab software for a better understanding of the classical problems by visualization of graphs, as Scilab has 2D and 3D plotting facilities.
Mitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis
Authors: Greer Yoshimi Endo , Hernandez Lidia , Fennell Emily M.J. , Kundu Manjari , Voeller Donna , Chari Raj , Gilbert Samuel F. , Gilbert Thomas S.K. , Ratnayake Shashikala , Tang Binwu , Hafner Markus , Chen Qingrong , Meerzaman Daoud , Iwanowicz Edwin , Annunziata Christina M. , Graves Lee M. , Lipkowitz Stanley 
Published: September 2022

Mitochondria are multifaceted organelles which are important for bioenergetics, biosynthesis, and signaling in metazoans. Mitochondrial functions are frequently altered in cancer to promote both the energy and the necessary metabolic intermediates for biosynthesis required for tumor growth. Cancer stem cells (CSC) contribute to chemotherapy resistance, relapse, and metastasis. Recent studies have shown that while non-stem, bulk cancer cells utilize glycolysis, breast CSCs are more dependent on oxidative phosphorylation (OxPhos) and therefore targeting mitochondria may inhibit CSC function. We previously reported that small molecule ONC201, which is an agonist for the mitochondrial caseinolytic protease (ClpP), induces mitochondrial dysfunction in breast cancer cells. In this study, we report that ClpP agonists inhibit breast cancer cell proliferation and CSC function in vitro and in vivo. Mechanistically, we found that OxPhos inhibition downregulates multiple pathways required for CSC function, such as the mevalonate pathway, YAP, Myc, and the HIF pathway. ClpP agonists showed significantly greater inhibitory effect on CSC functions compared with other mitochondria-targeting drugs. Further studies showed that ClpP agonists deplete NAD(P)+ and NAD(P)H, induce redox imbalance, dysregulate one-carbon metabolism and proline biosynthesis. Downregulation of these pathways by ClpP agonists further contribute to the inhibition of CSC function. In conclusion, ClpP agonists inhibit breast CSC functions by disrupting mitochondrial homeostasis in breast cancer cells and inhibiting multiple pathways critical to CSC function.Significance:ClpP agonists disrupt mitochondrial homeostasis by activating mitochondrial matrix protease ClpP. We report that ClpP agonists inhibit cell growth and CSC functions in breast cancer models by modulating multiple metabolic pathways essential to CSC function.
Extreme Measures: A National Descriptive Analysis of Closure and Restructuring of Traditional Public, Charter, and Private Schools
Authors: Harris Douglas N. , Martinez-Pabon Valentina 
Published: September 2022

Abstract
We describe the levels, trends, and patterns of school closure and restructuring in the United States from 1991 to 2019 across all sectors using a near census of K–12 schools. Focusing on the years with the best available data, 2014–18, we find that the annual closure rate of charter, private, and traditional public schools (TPSs) were 5.1, 2.9, and 0.9 percent, respectively. The annual restructuring rates are 2.0 percent for charter schools and 0.6 percent for TPSs. Regression analysis shows that these differences in closure and restructuring rates by sector drop slightly after controlling for student and school characteristics. The strongest predictor of increased closures is low student enrollment, especially in private schools. In charter and traditional public schools, achievement measures predict closure and restructuring nearly as strongly as enrollment. While racial and income composition are weaker predictors of closure/restructuring, that they predict at all, after controlling for many other factors, raises some equity concerns. We also discuss ways in which the forces behind closure/restructuring may be difficult to uncover with this type of quantitative analysis.
The Utility of ProbSevere v2.0 for Predicting Pulse Severe Thunderstorms
Authors: Gard Thomas L. , Fuelberg Henry E. , Cintineo John L. 
Published: September 2022

Abstract
Pulse severe storms are single-cell thunderstorms that produce severe wind and/or severe hail for a brief period of time. These storms pose a major warm season forecasting problem since forecasters presently do not have sufficient guidance to know which, if any, of the cells that are observed will become severe. The empirical Probability of Severe (ProbSevere) model, developed by the Cooperative Institute for Meteorological Satellite Studies (CIMSS), fuses real-time data to produce short-term (0–60 min), statistically derived probabilistic forecasts of thunderstorm intensity. This study evaluates the ability of ProbSevere to predict pulse severe storms in the southeast United States. ProbSevere objects fitting the usual definition of a pulse severe environment were matched with severe events from Storm Data to create a dataset of ProbSevere objects that corresponded to pulse severe thunderstorms. A null dataset consisted of objects in pulse severe environments that did not match with a severe event. Results reveal that ProbSevere’s probabilities are small to moderate at the times corresponding to pulse severe events. While probabilities of nonsevere storms are generally smaller, there are a large number of outliers. Lightning flash rate is the only predictor relevant to this study that correlates strongly with increasingly favorable pulse storm probabilities. We conclude that ProbSevere provides forecasters only limited guidance as to whether a pulse severe event will soon occur. Developing a version of ProbSevere specifically for pulse severe storms would likely lead to better predictability for this mode of convection.
Choroidal structural features of acquired vitelliform lesions in non-exudative age-related macular degeneration
Authors: Demirel Sibel , Yanık Özge , Özcan Gökçen , Batıoğlu Figen , Özmert Emin 
Published: September 2022

Purpose To define the choroidal morphological characteristics of non-exudative age-related macular degeneration (AMD) cases associated with acquired vitelliform lesions (AVLs). Methods This retrospective study included intermediate AMD patients with AVLs (Group1, 21eyes) and without AVLs (Group2, 21eyes). A healthy control group was (Group3, 23eyes) also included. Subfoveal choroidal thickness (SFCT), greatest basal diameter (GBD), and maximum height (MH) of the largest PED were measured on spectral domain optical coherence tomography. Internal reflectivity of PEDs and total choroidal area (TCA) were measured using ImageJ software. The TCA was binarized to the luminal area (LA) and stromal area. The choroidal vascularity index (CVI) was assessed. Results The mean SFCT, TCA, and LA were higher in Group 1 (290.3 ± 86.8 μm, 0.840 ± 0.302 mm2, 0.602 ± 0.227 mm2) than in Group 2 (215.6 ± 85.0 μm, 0.594 ± 0.183 mm2, 0.429 ± 0.139 mm2) ( p = 0.014, p = 0.017, p = 0.020, respectively). There was no significant difference in the CVI measurements between Group 1 and Group 2 (p = 1.000). The mean GBD and MH of the PED was higher in Group 1 (1443 ± 595 µm, 188 ± 86 µm) than in Group 2 (851 ± 368 µm, 119 ± 38 µm) ( p = <0.001, p = 0.001, respectively). Internal PED reflectivity was significantly lower in Group 1 (0.44 ± 0.21) than in Group 2 (0.66 ± 0.17) ( p = <0.001). Internal PED reflectivity showed negative correlation with GBD and MH of the PED in Group 1 (r = −0.587, p = 0.005; rho = −0.448, p = 0.042, respectively). In Group 2, internal PED reflectivity had a negative correlation with MH of the PED (rho = −0.511, p = 0.018). Conclusion Non-exudative AMD patients with AVLs are more prone to have a thick choroid and large hyporeflective PEDs as compared to the those without AVLs.
El sentido de coherencia y las habilidades para la vida como factores protectores en personas con prediabetes
Authors: Noguera-Suquet Judit , Reig-Garcia Glòria , Homs-Romero Erica , Gelabert-Vilella Sandra , Roura-Poch Pere , Malagón-Aguilera María del Carmen 
Published: September 2022

Objetivo: analizar el sentido de coherencia y las habilidades para la vida y su relación con el cumplimiento del estilo de vida saludable. Método: estudio observacional transversal en personas con prediabetes atendidas en atención primaria, quienes respondieron a un cuestionario con variables sociodemográficas y hábitos saludables y a los cuestionarios de sentido de coherencia y habilidades para la vida. Se realizó un análisis descriptivo, bivariante y un modelo de regresión múltiple. Resultados: los y las participantes con mayor sentido de coherencia son quienes presentan mayores habilidades para la vida (Pearson = 0.470; p ⩽ 0.001) y mantienen un estilo de vida más saludable (B:1.24; p = 0.001). Una mayor puntuación de las habilidades de la vida se relaciona con un estilo de vida saludable (Pearson = 0.355, p < 0.001). El sentido de coherencia predice el estilo de vida saludable (BB = 0.21, p = 0.001). Conclusión: las personas con prediabetes con un mayor sentido de coherencia y más habilidades para la vida realizan conductas más saludables con relación a la dieta, al ejercicio físico y al hábito tabáquico. Las personas con mayor sentido de coherencia tienen mayor probabilidad de seguir el estilo de vida saludable.
Prevalence of Neck Pain in Patients with Degenerative Cervical Myelopathy and Short-Term Response After Operative Treatment: A Cohort Study of 664 Patients From 26 Global Sites
Authors: Schneider Michel M. , Badhiwala Jetan H. , Alvi Mohammed Ali , Tetreault Lindsay A. , Kalsi Pratipal , Idler Randy K. , Wilson Jefferson R. , Fehlings Michael G. 
Published: September 2022

Study Design Ambispective cohort study. Objectives 1) To define the prevalence of neck pain in patients with degenerative cervical myelopathy (DCM). 2) To identify associated factors of preoperative neck pain in patients with DCM. 3) To assess the neck pain response to surgical intervention. Methods 757 patients with DCM were enrolled at 26 global sites from 2005 to 2011. A total of 664 patients had complete neck pain scores preoperatively (Neck Disability Index, NDI). The prevalence and severity of neck pain preoperatively and at the 6-months follow-up was summarized. Functional assessments of individuals with and without pain were compared. Associations of preoperative neck pain and related factors were evaluated. Results Preoperatively, 79.2% of patients reported neck pain while 20.8% had no neck pain. Of individuals with neck pain, 20.2% rated their pain as very mild, 27.9% as moderate, 19.6% as fairly severe, 9.6% as very severe and 1.9% as the worst imaginable. Functional status (mJOA), number of stenotic levels, age, and duration of symptoms did not significantly differ in patients with and without pain. Factors associated with the presence of neck pain were female gender, BMI ≥27 kg/m2, rheumatologic and gastrointestinal comorbidities, and age <57 years. Neck pain improved significantly from the preoperative examination to the 6-months postoperative follow-up ( P < .0001). Conclusion Here, we demonstrate a high prevalence of neck pain in patients with DCM as well as a link between gender, body weight, comorbidity and age. We highlight a significant reduction in neck pain 6 months after surgery.
Oldsite, K2Fe2+[(UO2)(SO4)2]2(H2O)8, a new uranyl sulfate mineral from Utah, USA: its description and implications for the formation and occurrences of uranyl sulfate minerals
Authors: Plášil Jakub , Kampf Anthony R. , Ma Chi , Desor Joy 
Published: September 2022

AbstractOldsite (IMA2021-075), ideally K2Fe2+[(UO2)(SO4)2]2(H2O)8, is a new uranyl sulfate mineral found on specimens from the North Mesa Mine group, Temple Mountain, San Rafael district, Emery County, Utah, USA. It is a secondary mineral occurring with alum-(K), halotrichite, metavoltine, quartz, römerite, stanleyite, sulphur, szomolnokite and mathesiusite. It forms rectangular blades flattened on {010} and elongated on [001], reaching ~0.3 mm in length. Crystals are yellow in colour, transparent with a vitreous lustre; the streak is very pale yellow. The mineral is non-fluorescent. Cleavage is excellent on {100} and perfect on {010}; the Mohs hardness is ~2. Crystals are brittle with irregular, splintery fracture. The density measured by flotation in a mixture of methylene iodide and toluene is 3.31 g⋅cm–3; the calculated density is 3.298 g⋅cm–3 for the empirical formula and 3.330 g⋅cm–3 for the ideal formula. Oldsite is biaxial (+), with α = 1.552(2), β = 1.556(2) and γ = 1.588(2) (measured in white light). The 2V measured directly on a spindle stage is 37(1)°; the calculated 2V is 39.6°. Dispersion is r < v, moderate. The optical orientation is X = b, Y = a and Z = c. The mineral is non-pleochroic. The empirical formula of oldsite (on the basis of 28 O apfu) is K1.93(Fe2+0.53Zn0.31V3+0.09Mg0.08)Σ1.02[(U0.98O2)(S1.01O4)2]2(H2O)8. The Raman spectrum is dominated by the vibrations of SO42– and UO22+ units. Oldsite is orthorhombic, Pmn21, a = 12.893(3), b = 8.276(2), c = 11.239(2) Å, V = 1199.2(5) Å3 and Z = 2. The five strongest powder X-ray diffraction lines are [dobs, Å (I, %) (hkl) ]: 8.29 (59) (010), 6.47 (82) (200), 5.10 (62) (210), 4.65 (100) (012, 211) and 3.332 (55) (022, 221). The crystal structure of oldsite was refined from single-crystal X-ray data to R = 0.0258 for 2676 independent observed reflections, with Iobs > 3σ(I). Oldsite is an Fe2+ analogue of svornostite; its crystal structure is based upon infinite chains of uranyl-sulfate polyhedra, which comprises pentagonal UO7 bipyramids sharing four of their equatorial vertices with sulfate tetrahedra such that each tetrahedron is linked to two uranyl bipyramids to form an infinite chain (the free, non-linking equatorial vertex of the uranyl bipyramid is an H2O group). The broader discussion on the origin and composition of uranyl sulfate minerals is made. The new mineral name honours American mineralogist, Dr. Travis A. Olds for his contribution to uranium mineralogy.
Identification and characterization of miRNAs and PHAS loci related to the early development of the embryo and endosperm in Fragaria × ananassa
Authors: Jing Xiaotong , Zhang Hong , Huai Xinjia , An Qi , Qiao Yushan 
Published: September 2022

Abstract
Background
The strawberry fleshy fruit is actually enlarged receptacle tissue, and the successful development of the embryo and endosperm is essential for receptacle fruit set. MicroRNAs (miRNAs) and phased small interfering RNAs (phasiRNAs) play indispensable regulatory roles in plant growth and development. However, miRNAs and phasiRNAs participating in the regulation of strawberry embryo and endosperm development have yet to be explored.

Results
Here, we performed genome-wide identification of miRNA and phasiRNA-producing loci (PHAS) in strawberry seeds with a focus on those involved in the development of the early embryo and endosperm. We found that embryos and endosperm have different levels of small RNAs. After bioinformatics analysis, the results showed that a total of 404 miRNAs (352 known and 52 novel) and 156 PHAS genes (81 21-nt and 75 24-nt genes) could be found in strawberry seed-related tissues, of which four and nine conserved miRNA families displayed conserved expression in the endosperm and embryo, respectively. Based on refined putative annotation of PHAS loci, some auxin signal-related genes, such as CM3, TAR2, AFB2, ASA1, NAC and TAS3, were found, which demonstrates that IAA biosynthesis is important for endosperm and embryo development during early fruit growth. Additionally, some auxin signal-related conserved (miR390-TAS3) and novel (miR156-ASA1) trigger-PHAS pairs were identified.

Conclusions
Taken together, these results expand our understanding of sRNAs in strawberry embryo and endosperm development and provide a genomic resource for early-stage fruit development.
Caregiver perceptions of in-home COVID-19 testing for children with medical complexity: a qualitative study
Authors: Jolliff Anna , Werner Nicole E. , Barton Hanna J. , Howell Kristina Devi , Kelly Michelle M. , Morgen Makenzie , Ehlenbach Mary , Warner Gemma , Katz Barbara , Kieren Madeline , DeMuri Gregory , Coller Ryan J. 
Published: September 2022

AbstractBackgroundIn-home direct antigen rapid testing (DART) plays a major role in COVID-19 mitigation and policy. However, perceptions of DART within high-risk, intellectually impaired child populations are unknown. This lack of research could negatively influence DART uptake and utility among those who stand to benefit most from DART. The purpose of this study was to describe caregivers’ perceptions of an in-home COVID-19 DART regimen in children with medical complexity, including the benefits and limitations of DART use.MethodsThis qualitative study was a subproject of the NIH Rapid Acceleration of Diagnostics Underserved Populations research program at the University of Wisconsin. We combined survey data and the thematic analysis of semi-structured interview data to understand caregivers’ perceptions of in-home COVID-19 testing and motivators to perform testing. Caregivers of children with medical complexity were recruited from the Pediatric Complex Care Program at the University of Wisconsin (PCCP). Data were collected between May and August 2021.ResultsAmongn = 20 caregivers, 16/20 (80%) of their children had neurologic conditions and 12/20 (60%) used home oxygen. Survey data revealed that the largest caregiver motivators to test their child were to get early treatment if positive (18/20 [90%] of respondents agreed) and to let the child’s school know if the child was safe to attend (17/20 [85%] agreed). Demotivators to testing included that the child could still get COVID-19 later (7/20 [35%] agreed), and the need for officials to reach out to close contacts (6/20 [30%] agreed). From interview data, four overarching themes described perceptions of in-home COVID-19 testing: Caregivers perceived DART on a spectrum of 1) benign to traumatic and 2) simple to complex. Caregivers varied in the 3) extent to which DART contributed to their peace of mind and 4) implications of test results for their child.ConclusionsAlthough participants often described DART as easy to administer and contributing to peace of mind, they also faced critical challenges and limitations using DART. Future research should investigate how to minimize the complexity of DART within high-risk populations, while leveraging DART to facilitate safe school attendance for children with medical complexity and reduce caregiver burden.
Advantages and challenges of fostering cognitive integration through virtual collaborative learning: a qualitative study
Authors: Ignacio Jeanette , Chen Hui-Chen , Roy Tanushri 
Published: September 2022

Abstract
Background
The drastic shift from face-to-face classes to online learning due to the COVID-19 pandemic has enabled educators to ensure the continuity of learning for health professions students in higher education. Collaborative learning, a pedagogy used to facilitate knowledge integration by helping students translate theory from basic sciences to clinical application and practice, has thus been transformed from a face-to-face to a virtual strategy to achieve the learning objectives of a multi-disciplinary and integrated module.

Objectives
This study aimed to describe and evaluate, through focus group discussions, a virtual collaborative learning activity implemented to assist first year undergraduate nursing students to develop cognitive integration in a module consisting of pathophysiology, pharmacology, and nursing practice.

Methods
Fourteen first year undergraduate students and four faculty involved in facilitating the virtual collaboration participated in the study. Focus group discussions were conducted to elicit the perceptions of students and staff on the virtual collaborative learning session conducted at the end of the semester.

Results
Three themes were generated from the thematic analysis of the students’ focus group scripts. These were: (1) achieving engagement and interaction, (2) supporting the collaborative process, and (3) considering practical nuances. The three themes were further subdivided into subthemes to highlight noteworthy elements captured during focus group discussions. Three themes also emerged from the focus group discussion scripts of faculty participants: (1) learning to effectively manage, (2) facing engagement constraints, and (3) achieving integration. These themes were further sectioned into salient subthemes.

Conclusion
The virtual collaborative learning pedagogy is valuable in fostering cognitive integration. However, meticulous planning considering various variables prior to implementation is needed. With better planning directed at addressing the learners’ needs and the faculty’s capabilities and readiness for online learning pedagogies, and with a strong institutional support to help mitigate the identified constraints of virtual collaborative learning, students and faculty will benefit.