bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-Metastatic Potential of Pakistani Spice Box
Authors: Wajahat Jariya , Naeem Sadaf 
Published: October 2022

Inhibition of vascular endothelial growth factor 2 (VEGFR2), cyclooxygenase-2 (COX-2), NFkB inhibiting kinase1 (NIK) and hypoxia inducible factor-2 α(HIF-2 α) nexus can block cancer spread. This study aimed at findingphytochemicals in spices for inhibition of above mentioned target proteins in order to prevent/ treat cancer.The crystal structures for VEGFR2, COX-2, NIK and HIF-2α were downloaded from RCSB protein data bank withPDB IDs of 3VHE, 5IKQ, 4IDT& 4XT2 respectively. (The chemical constituents of the spices: nutmeg, cinnamon,black pepper, red chili, clove, black caraway seed, fennel, star anise, turmeric and coriander were collectedfrom Dr. Duke's phytochemical and ethnobotanical databases. Next the 3D structures of the chemicals weredownloaded from PubChem. These chemicals were then docked against crystal structures of the target proteins using Glide docking software from Schrodinger. The chemicals that docked successfully against 3VHE ( vascular endothelial growth factor receptor 2) included : Apiin, kaempferol, quercetin, cymaroside and capsorubin from red chili with dock scores of (-11.301,-11.076,-10.990,-10.196,-9.82)kcal/mol respectively, quercetin and trichostachine from black pepper with dock scores -11.546 kcal/mol and -9.017 kcal/mol, curcumin from turmeric with -9.019kcal/mol score, quercetin, isokaemferide, rhamnetin and apigetrin from coriander with dock scores of -11.574kcal/mol, -10.894cal/mol, -10.484, -10.364 cal/mol; foeniculoside ii from fennel with dock score -9.065 kcal/mol, procyanidin B-2 from cinnamon with dock score of -9.218 kcal/mol and kaempferide, rhamnocitrin, myricetin, rhamnetin from clove with dock scores of -10.927cal/mol, -10.593cal/mol, -10.467cal/mol, - 9.931cal/mol - 10.59cal/mol respectively. For cyclooxygenase-2 (5IKQ), Rhamnetin 3, 3', 4'-triglucoside from black pepper and procyanidin from cinnamon showed successful docking. For NFkB-inducing kinase (4IDT), cubebin from black pepper and riboflavin from coriander showed successful docking. Successfully docked compounds against 4XT2(hypoxia inducible factor-2) included AC1NQWCK [tert-butyl N-[(2S)-1-[(2S,4R)-2-[[1-(cyclopropylsulfonylcarbamoyl) cyclobutyl]carbamoyl]-4-(7-methoxy-2-phenylquinolin-4 yl)oxypyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate ] from red chili and catechin from cinnamon. Because of successful in-silico docking with the target proteins, these spices can be predicted as cancer curbing agents. In future these compounds can be tested in vitro and in vivo for their potential inhibitory activity.
How to cite this: Kalsoom J, Naeem S. Anti-Metastatic Potential of Pakistani Spice Box. Life and Science. 2022; 3(4): 206-206. doi: http://doi.org/10.37185/LnS.1.1.258
Protective Effect of Pyridoxine on Lead Nitrate Induced Histomorphological Changes in Rat Liver
Authors: Abbasi Sumaira , Khan Huma Musarrat , Khan Muhammad Yunus 
Published: October 2022

Objective: To study the effects of Pyridoxine on lead nitrate generated histological and morphological changesin rat liver.Study Design: It was an experimental study.Place and Duration of Study: The study was carried out at Anatomy Department of College of Physicians andrd st Surgeons, Islamabad, Pakistan from 03rd September, 2019 to 31st December, 2020.Materials and Methods: In this study 90 male rats were used and divided into three groups. Control group Awas kept on normal diet. Experimental group B1 was given lead nitrate and B2 was given lead nitrate andpyridoxine by oral gavage for a period of 2 weeks. All rats were sacrificed after 2 weeks. Results of quantitativevariables such as inflammatory and Kupffer cells were expressed in mean ± S.D. To detect significant differenceamong the groups, ANOVA accompanied by Post Hoc Tukey test was applied and qualitative data such as central vein congestion, steatosis, and necrosis were expressed in percentages and Chi Square test.Results: Exposure to pyridoxine reduces the degenerative changes caused by lead nitrate such as increase inthe number of Kupffer and inflammatory cells. Central vein congestion, steatosis and necrotic foci were alsoreduced with a significant p-value.Conclusion: An ameliorative effect of pyridoxine on the degenerative changes in the liver induced by leadnitrate was proven through a decrease in the number of kupffer and inflammatory cells. Central veincongestion, steatosis and necrotic foci were also reduced significantly.
How to cite this: Abbasi S, Khan HM, Khan MY. Protective Effect of Pyridoxine on Lead Nitrate Induced Histomorphological Changes in Rat Liver. Life and Science. 2022; 3(4): 163-167. doi: http://doi.org/10.37185/LnS.1.1.269
Choreiform-Ballistic Movements Due to Endocrine Deficiencies
Authors: Haroon Maryam 
Published: October 2022

Choreiform-ballistic movements are often associated with lesions in the basal ganglia and subthalamicnucleus. For a patient with dancing movements, hyperglycemia might be an initial presentation. We herebypresent a case of a young 19 years old girl already on insulin and presented with the sub-acute onset ofabnormal movements. The purpose of this case report was to elaborate the possibility of choreiformmovements as a rare presentation of endocrine deficiencies like type I diabetes in association withpseudohypoparathyroidism as well as the role of insulin, calcium, and vitamin D analogues in reducing thefrequency and severity of these movements. Literature review showed a similar presentation with hyperosmolarnon-ketotic coma / hyper-osmolar hyperglycemic state (HONK/HHS) secondary to type 2 diabetesmellitus in middle and old-aged patients but not reported so far in young patients having type I diabetesmellitus with other underlying endocrine abnormalities.How to cite this: Haroon M. Choreiform-Ballistic Movements Due to Endocrine Deficiencies. Life and Science. 2022; 3(4): 203-205. doi: http://doi.org/10.37185/LnS.1.1.274
O corpo-vivente: centro de orientação eu-mundo-outro
Authors: Maria Aparecida Viggiani Bicudo  
Published: October 2022

Este artigo tem como pergunta norteadora: "como e por que o corpo vivente é assumido na fenomenologia husserliana enquanto centro orientador eu-mundo-outro?". No intuito de perseguir a direção por ela indicada, toma-se por base os Capítulos Terceiro e Quarto do "Idee per uma Fenomenologia pura e per uma filosofia fenomenológica" volume II (Husserl, 2002, 2005), do parágrafo 35 ao 47. Entende-se que o estudo desse texto viabiliza a exposição das ideias que esse autor apresenta sobre o corpo-vivente, as quais abordam questões concernentes à fisicalidade do corpo, às suas dimensões psicofísicas, à constituição de valores, à constituição da intersubjetividade.
Analisis Stabilitas Tanggul Penahan Tanah Pedestrian Zona II Situ Bagendit
Authors: Nurhuda Tiara 
Published: October 2022

Abstract: Situ Bagendit is one of the natural tourism areas in Garut Regency with an area of 124 Ha. Besides being a tourist attraction, Bagendit Lake is also a suggestion for irrigation in the surrounding area. In addition to channeling irrigation, earth retaining embankments built together with pedestrians must also meet the safety requirements of stability. This study aims to determine the value of the safety factor of the Situ Bagendit embankment against slipping and overturning. To determine the value of stability, the forces and moments acting on the embankment and water are analyzed. The value of slip or shear stability is 1.73 and the value of rolling stability is 2.1, where the value is categorized as safe because it is more than 1.25. It was concluded that the Situ Bagendit II embankment was categorized as safe against sliding and overturning
Abstrak: Situ Bagendit merupakan salah satu kawasan wisata alam di Kabupaten Garut dengan luas 124 Ha. Selain menjadi objek wisata, situ Bagendit juga sebagai saran irigasi di daerah sekitar. Disamping untuk menyalur irigasu, tanggul penahan tanah dibangun bersamaan dengan pedestrian juga harus memenuhi persyaraytan aman dari stabilitas. Penelitian ini bertujuan untuk mengetahui nilai faktor aman tanggul Situ Bagendit terhadap gelincir dan guling. Untuk mengetahui nilai stabilitas maka dianalisis gaya-gaya dan momen yang bekerja pada tanggul dan air. Nilai stabilitas gelincir atau geser adalah 1,73 dan nilai stabilitas guling adalah 2,1, dimana nilai tersebut dikategorikan aman karena lebih dari 1,25. Dissipulkan bahwa tanggul Situ Bagendit II dikategorikan aman terhadap geser maupun guling
The relationship between ulcerative colitis activity and vitamin D, mean platelet volume and platelet distribution width
Authors: KAYA Mehmet Nur , YILDIZ Ayla 
Published: October 2022

Aim: In our study, we aimed to show the relationship between ulcerative colitis activity and vitamin D, platelet distribution width, and mean platelet volume.
Material and Method: Our study was conducted at the Internal Medicine Clinic. We planned to cross-sectionally investigate the severity of ulcerative colitis activity, vitamin D level, mean platelet volume, platelet distribution width and other laboratory parameters of patients admitted to the hospital. The Truelove and Witts’ severity index was used to determine ulcerative colitis activity. In accordance with the guidelines, serum 25-OH vitamin D levels of >30 ng/ml were considered as sufficient vitamin D, 20-30 ng/ml as vitamin D insufficiency,
Ambipolar Diffusion in the Lower Solar Atmosphere: Magnetohydrodynamic Simulations of a Sunspot
Authors: MacBride Conor D. , Jess David B. , Khomenko Elena , Grant Samuel D. T. 
Published: October 2022

Abstract
Magnetohydrodynamic (MHD) simulations of the solar atmosphere are often performed under the assumption that the plasma is fully ionized. However, in the lower solar atmosphere a reduced temperature often results in only the partial ionization of the plasma. The interaction between the decoupled neutral and ionized components of such a partially ionized plasma produces ambipolar diffusion. To investigate the role of ambipolar diffusion in propagating wave characteristics in the photosphere and chromosphere, we employ the Mancha3D numerical code to model magnetoacoustic waves propagating through the atmosphere immediately above the umbra of a sunspot. We solve the nonideal MHD equations for data-driven perturbations to the magnetostatic equilibrium and the effect of ambipolar diffusion is investigated by varying the simulation to include additional terms in the MHD equations that account for this process. Analyzing the energy spectral densities for simulations with/without ambipolar diffusion, we find evidence to suggest that ambipolar diffusion plays a pivotal role in wave characteristics in the weakly ionized low density regions, hence maximizing the local ambipolar diffusion coefficient. As a result, we propose that ambipolar diffusion is an important mechanism that requires careful consideration into whether it should be included in simulations, and whether it should be utilized in the analysis and interpretation of particular observations of the lower solar atmosphere.
La modélisation cartographique des controverses, un outil au service de l’esprit critique ?
Authors: Desfriches Doria Orélie 
Published: October 2022

L’objet de l’article vise à présenter un retour réflexif sur les acquisitions des étudiants, en matière d’esprit critique, lors d’expérimentations pédagogiques autour d’enseignements sur l’analyse des controverses. Nous abordons les apports des SIC à ce champ de recherches, notamment sur la considération du rôle des médias et des publics dans l’étude des controverses et la diversification des objectifs des enseignements de controverses. Nous décrivons notre cadre théorique d’appréhension de l’objet « controverse » et notre approche originale d’analyse des controverses (MASCO). Un focus est ensuite proposé sur les liens entre cartographie et modélisation dans l’optique de préciser un autre apport des SIC aux études de controverses. Par la suite, nous présentons l’analyse de résultats partiels de l’évaluation de l’enseignement expérimental que nous dispensons. Nous terminons en discutant les méthodologies d’évaluation de ces enseignements de l’esprit critique par les controverses.
Les signes à l’épreuve des systèmes de croyance
Authors: Saemmer Alexandra , Tréhondart Nolwenn 
Published: October 2022

Suivant l’idée que l’éducation aux médias et à l’information constitue à la fois un champ de recherche théorique et une praxis pédagogique, nous présentons, dans cet article, une démarche critique en sémiotique sociale que nous développons sur différents terrains depuis plusieurs années (photographies d’actualité, sites de presse en ligne, séries, livres numériques, plateformes sociales). Après un rapide état de l’art consacré aux conceptualisations de la « réflexivité », nous nous pencherons sur deux objets centraux actuellement dans l’éducation aux médias — les réseaux sociaux et l’image d’actualité — en montrant comment cette démarche de recherche transposée en contexte pédagogique permet d’engager l’apprenant.e et l’enseignant.e dans un processus de co-construction réflexif des significations, qui permet de compléter les méthodes de décryptage classique par une prise de conscience quant au rôle joué par les habitudes, normes, allants de soi et croyances dans la production du sens.
Carnet de controverses en temps de Covid : pour une autre communication de crise en santé
Authors: Zacklad Manuel 
Published: October 2022

Dans cet article nous présentons une enquête qui croise ethnographie en ligne et ethnographie engagée sur le réseau LinkedIn. Nous commençons par présenter une typologie « anthropo-épistémique » des postures de recherche pour préciser l’approche qui est la nôtre dans l’étude des groupes subalternes que nous avons observés sur ce réseau social. Nous décrivons ensuite quatre espaces de controverses actifs liés à la gestion de la crise du Covid-19 et à la communication à son égard : controverses liées à l’importance de l’épidémie, à l’interdiction des traitements, à la pertinence des mesures sociales telles que confinement national et couvre-feux et enfin, l’imposition des passes sanitaire et vaccinal. L’analyse de ces controverses, dont les protagonistes sont souvent des experts du domaine sans rapport avec la vision caricaturale du complotiste ignare et malfaisant, montre que les méthodes classiques de communication en santé, basées sur des méthodes persuasives, sont inopérantes et tendent même à produire l’effet inverse de celui recherché. Nous plaidons pour une « communication de crise épistémique » fondée sur l’intelligence coopérative du public, des médiateurs, des spécialistes et des scientifiques, qui ouvre des espaces d’expérimentation et de débat à toutes les échelles où les échanges sont possibles.
Les petits bardes du carnage : la chanson de guerre française pour enfants (1914-1918)
Authors: Parenteau Olivier 
Published: October 2022

Cet article est consacré à l’étude de chansons patriotiques françaises destinées à être entonnées par les enfants ayant grandi tandis que la Première Guerre mondiale faisait rage. Les comptines analysées, tirées de recueils parus en 1915 et en 1916, attestent d’une volonté d’embrigader l’enfance et d’imprégner les jeunes d’un discours propagandiste manichéen, volontiers violent, rappelant que la France sortira victorieuse du conflit qu’elle mène au nom de la Civilisation contre la Barbarie. Si l’étude détaillée de ces chansons permet de révéler les « stratégies » poétique et rhétorique mises en place par leur auteur – lesquelles sont d’ailleurs très similaires à celles qui peuvent être observées dans les chansons pour adultes –, elle révèle aussi qu’il arrive à ces comptines d’ébranler la doxa militariste.
Efficacy and safety of FLOT regimen vs DCF, FOLFOX, and ECF regimens as perioperative chemotherapy treatments for resectable gastric cancer patients; a report from the middle east
Authors: Farrokhi Pegah , Sadeghi Alireza , Sharifi Mehran , Riechelmann Rachel , Moghaddas Azadeh 
Published: October 2022

Background and purpose:
This study aimed to compare the efficacy and toxicity of perioperative chemotherapy regimens including epirubicin, cisplatin, 5-fluorouracil (ECF), docetaxel, cisplatin, 5-fluorouracil (DCF), leucovorin, 5-fluorouracil, oxaliplatin (FOLFOX), and 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) to identify the most effective chemotherapy regimen with less toxicity.

Experimental approach:
This retrospective cohort study (2014-2021) was based on 152 eligible resectable gastric cancer patients who had received one of the perioperative mentioned chemotherapy regimens and followed for at least two years. The primary endpoint of this study was overall survival (OS), progression-free survival (PFS), overall response rate (ORR), and R0 resection.

Findings / Results:
Of included patients, 21%, 33.7%, 24.3%, and 21% had received ECF, DCF, FOLFOX and FLOT, respectively. After the median 30-month follow-ups, OS was higher with the FLOT regimen in comparison with other regimens (hazard ratio = 0. 276). The median OS of the FLOT regimen was 39 months. Besides, the median OS was 28, 25, and 21 months for DCF, FOLOFX, and ECF regimens, respectively. Moreover, a median PFS of 24, 18, 17, and 14 months was observed for FLOT, DCF, FOLFOX, and ECF regimens, respectively (Log-rank < 0.001). FLOT regimen showed 84. 4% ORR which was notably higher than other groups.

Conclusions and implications:
For resectable gastric cancer patients, the perioperative FLOT regimen led to a significant improvement in patients’ OS and PFS versus ECF, DCF, and FOLFOX regimens. As such, the FLOT regimen could be considered the optimal option for managing resectable gastric cancer patients.
SUBSTANTIATION OF THE ARRANGEMENT AND OPERATION OF THE MOZYR UNDERGROUND GAS STORAGE FACILITY
Authors: Mayorov V. V. , Ausev V. G. , Parfenov K. V. , Lugovski N. N. , Krasnovski S. V. , Mashezau A. A. , Lukashevich A. A. 
Published: October 2022

The relevance and importance of underground gas storages for the energy security of the Republic of Belarus is denoted. The types of underground gas storage facilities in operation on the territory of the republic are indicated.
The geological conditions of the Mozyr salt massif in the area of the mine workings are given. The features of the structure of the Mozyr salt dome are considered. Information about the rock salt deposits of the Zalessky layers suitable for creating caverns is given. Mining and geological conditions are described and favorable factors of an underground gas storage creation in rock salt deposits under the conditions of the Mozyr salt dome are denoted. Information about the screening effect of the roof strata is given. Mathematical modeling was carried out and the assessment of the suitability of the existing
salt caverns is given. During the conversion of existing and the creation of new caverns, as well as in the process of their operation (injection-storage-selection) long-term sustainability to the effects of pressures emerging has been confirmed.
Formulas for determination the maximum gas pressure limit, the permissible maximum and minimum operating pressure as well as the required span of the cavern are given. The test pressure range for determining the tightness of the caverns is indicated. The conditions for choosing the minimum operating pressure in the cavern as well as the safety margin factor in relation to specific conditions are determined. In fact, the suitability and prospects of creating underground gas storage facilities in the salt domes of the Pripyat trough have been confirmed.
Strategic Role of Huduma Centre Initiatives on Public Service Delivery among Residents of Kapsabet Town, Nandi County, Kenya
Authors: Sawe Maxrine Jebet , Kwasira Josphat 
Published: October 2022

Purpose: The current study sought to assess the strategic role of Huduma centres on public service delivery among residents of Kapsabet town, Nandi County, Kenya. The specific objectives of the study included; to determine the role of change management, strategic communication, strategic leadership and strategic decision making on public service delivery among residents of Kapsabet town, Nandi County, Kenya. The study was anchored on the following theories; the Kurt Lewin’s change management theory, theory of cybernetic, strategic leadership theory and the rational decision making theory.
Methodology: The study adopted an explanatory research design. The study target population was 750 customers who access Huduma services daily at the Huduma center in Kapsabet town. The sample size was 261 customers. Simple random sampling technique was used to select the respondents. Questionnaires were used to collect data in this study. Pilot testing was undertaken at Eldoret Huduma center. This study adopted content validity. Cronbach’s alpha was used to measure reliability of the research instrument. The data collected was analyzed using both descriptive and inferential statistics.
Findings: The study findings indicated that change management has a positive and significant role on public service delivery (β=0.016, p < 0.05), strategic communication has a positive and significant role on public service delivery (β=0.246, p < 0.05), strategic leadership has a positive and significant role on public service delivery (β=0.075, p < 0.05), strategic decision making has a positive and significant role on public service delivery (β=0.519, p<0.05).
Unique contribution to theory, practice and policy: This study concludes that change management, strategic communication, strategic leadership and strategic decision making have a significant role on public service delivery. The study recommends that the management of Kapsabet Huduma center should have a policy on stakeholder’s engagement in decision making at the facility. They should implement a policy on information sharing among the target audience of the facility. A policy on human resource development should continue to exist at the facility and also there should be a policy that will operationalize strategic teaming by the top level managers at the facility. The study contributed to existing body of knowledge by forming basis for further research in the area of strategic role of Huduma centers’ and public service delivery.
LAS FUNCIONES QUE RIGEN LA MOVILIDAD EN LA ZONA METROPOLITANA DE LA CIUDAD DE MÉXICO
Authors: Luna Gómez Luis Alberto 
Published: October 2022

AS FUNÇÕES QUE REGEM A MOBILIDADE NA ÁREA METROPOLITANA DA CIDADE DO MÉXICO
O Área Metropolitana da Cidade do México é um espaço de especulação financeira através do mercado imobiliário, que aproveita a oportunidade para executar rodovias e obras, concentrando receitas. As viagens ao centro da cidade aumentaram para fins de compras e entretenimento, por meio de aplicativos eletrônicos que acessam uma densidade compactada de imagens e luzes. Condições que reciclam a crise, ou seja, a queda da renda familiar que se delineia nos primeiros resultados do Censo 2020 elaborado pelo Instituto Nacional de Estatística, Geografia e Informática.