bluuebunny/crossref_metadata_2025_split huggingface dataset:
A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia
Authors: Ren Zhihong , Kim Arum , Huang Yu-Ting , Pi Wen-Chieh , Gong Weida , Yu Xufen , Qi Jun , Jin Jian , Cai Ling , Roeder Robert G. , Chen Wei-Yi , Wang Gang Greg 
Published: February 2022

SignificanceAcute myeloid leukemias (AMLs) with NUP98-NSD1 or MLL abnormality are generally aggressive, demanding a better understanding of the underlying oncogenic mechanisms. We show that these AMLs rely on a regulatory axis involving PRC2–|Kdm5b–|stemness genes for sustaining an oncogenic program. The H3K27 methylase activity of polycomb repressive complex 2 (PRC2) is crucial for repressing Kdm5b, a corepressor carrying a H3K4me3 reader domain, that antagonizes the AML oncoproteins by directly binding to and down-regulating the AML stemness genes, thereby suppressing acute leukemogenesis. Such an AML-suppressing role of Kdm5b is not dependent on its intrinsic demethylase activity but requires its scaffold and/or chromatin association functions. The findings of this study shall aid in potential therapeutics of the affected AML patients.
Spring triticale yield in mixed crops for sustainable development of the environment
Authors: Mefodyev G A , Alexandrova A N , Yakovleva M I , Eliseeva L V , Shashkarov L G 
Published: February 2022

AbstractSowing spring triticale based on mixtures of varieties may be more promising than sowing monoculture varieties. Four varieties of spring triticale (Ulyana, Rovnya, Saur and Khaikar) were evaluated with two-component (1:1) and three-component (1:1:1) variety mixtures. Studied 6 variants of two-component mixtures and 4 three-component mixtures. The research was carried out on the experimental field of the Chuvash State University in 2018-2020. The effectiveness of the variety mixtures was determined by a comparative analysis of the actual and possible yield. The stability of crops in terms of yield was assessed by the coefficient of variation. In monoculture, the Saur variety had the highest yield. The two-component crops were the highest yielding and stable over the years compared to the one-component and three-component crops. The most promising variety mixtures turned out to be Ulyana/Khaikar, Rovnya/Saur and Saur/Khaikar, which allow increasing yields by 4.7-20.2 100kg/ha.
Probiotic feed preparations for aquaculture facilities to ensure sustainable development and preservation of species biodiversity
Authors: Matrosova I V , Panchishina E M , Politaeva A A , Kornienko N L 
Published: February 2022

Abstract
Under the conditions of an increasing anthropogenic load on marine ecosystems, bottom and pelagic communities can undergo significant changes, and even cardinal rearrangements. To assess coastal waters state and their further changes, information is needed both about individual components and ecosystems as a whole. Some biological characteristics of Far Eastern sea cucumber, gray sea urchin and scallop from different water areas have been investigated. At present, an urgent task is the artificial reproduction of aquatic organisms in order to preserve their number in natural populations by reducing the fishing pressure on them. An effective way of aquatic organisms replenishing natural accumulations and obtaining marketable products is technologies development and implementation for juveniles cultivation in factory conditions using feed preparations. The quality of probiotic supplements was assessed for compliance with regulatory documents requirements, as well as those declared by the manufacturer. This work results will serve as the basis for eco-friendly mariculture enterprises creation for the cultivation of aquatic organisms, taking into account the need for natural resources rational use and environmental protection.
Application of a new generation of growth regulators on winter wheat crops in the conditions of the steppe zone of the RNO-Alania
Authors: Tedeeva A A , Mamiev D M , Tedeeva V V 
Published: February 2022

Abstract
Currently, micronutrients and plant growth regulators, which are used to obtain economically significant effects, are the major focus in the country. Therefore, the main task of scientific research in the field of studying growth regulators is to find and introduce into production environmentally safe, non-harmful effects on both plants and the environment.It is the first time when in the conditions of the steppe zone of the Mozdok district, the Republic of North Ossetia – Alania, in the scientific and production department of the SKNIIGPSKH VNTS RAN “Oktyabrsky” were studied the growth regulators of the new generation Edagum SM and Mers B on two varieties of winter wheat Alekseich and Grom selection of FSBSI Lukyanenko National Grain Centre.As a result of the use of micro-fertilizers, the growth regulator and their tank mixture, one can see the increased density of standing plants of winter wheat. The studied variants had a significant impact on the yield and quality indicators of the winter wheat products obtained. Productivity increased by 0.95-1.45 t/ha. With a maximum yield of 4.82 t/ha in the variant with the use of tank mixture on the Alekseich variety, the conditional net income amounted to 21.87 thousand rubles/ha, at the level of production profitability of 115.00%. In a similar variant with the Grom variety, the yield was 4.62 t/ha with a production profitability level of 105.60%.
Research on the ecologization of agriculture: improvement of crop rotations and biological soil fertility reproduction systems
Authors: Nikitina O V , Nagornaya O V , Dolgopolova N V 
Published: February 2022

Abstract
Currently, the issue of ecological farming is becoming especially acute due to economic and environmental instability in general and in agriculture in particular. Sufficient facts have been accumulated in agricultural science, indicating that long-term unsystematic and uncontrolled use of chemical nutrients leads to a deterioration of the ecological situation, the accumulation of harmful elements in plants, soil, and reservoirs. All this leads to the destabilization of agricultural landscapes, including fauna and flora, and ultimately poses a serious threat to man himself.
Framing regional innovation and technology policies for transformative change
Authors: Solodov S V , Mamai I B , Pronichkin S V 
Published: February 2022

Abstract
The current state of social and economic development of regions requires new approaches to increasing the efficiency of their activities, and above all scientific approaches to forecasting, as one of the main components of the strategy of transformative changes. It is proposed to use an architecture based on neuro-fuzzy networks for forecasting regional development, which is characterized by a high learning rate due to the linear dependence of outputs on adjustable weights. Scientific and methodological approaches are developed to determine the global minimum of the learning criterion, taking into account the decision rules “if-then”.
The results of the application of the ZetaGel technology at the fields of TPE «Kogalymneftegaz»
Authors: Yarkeeva N R , Imangulov D V 
Published: February 2022

Abstract
At present the hydraulic fracturing of formation is the main type of the geological and technical measures in the oilfields of western Siberia. In 2019-2020 the hydrofracturing of formation’s share was 48.6%. The widespread use of hydrofracturing is due to its main advantage - an instant increase in well production, as a result of increasing the permeability of the bottomhole formation zone by several orders. However, water, as a more mobile agent, is ahead of oil and occupies the most permeable channels first, which, as a result, leads to intensive watering of wells. This fact is the main disadvantage of hydrofracturing. The extensive use of this production stimulation’s method and the number of its negative consequences are the cause of the relevance for the hydrofracturing’s technology improvements. The article describes one of the latest and most promising ways to improve its efficiency - the ZetaGel technology consisting of the surface-active agents’ adding to the breakdown agent for further formation of the polymer-free gel system, explores the process of solution preparation, studies its physicochemical properties, and analyzes the geological and field data on the application of ZetaGel technology at the fields of TPE «Kogalymneftegaz» and the advantages of this technology in comparison with the standard operation of hydraulic fracturing. In addition, the authors of the article proposed recommendations for the further use of this system. The use of cross-linked gel has solved the problems related to the bottom water’s breaches, the pore canals’ bridging by the proppant and the damages of the critical area of formation and the edge. The rheological properties of the liquid in turn allow keeping the proppant in suspension and pushing it deep into the formation, thereby increasing the permeability of the proppant pack.
The role of zeolites in increasing the efficiency of fertilizers in the cultivation of agricultural crops and the sustainable development of the environment
Authors: Eliseev I P , Eliseeva L V , Vasiliev O A , Dimitriev V L , Lozhkin A G , Fadeeva N A 
Published: February 2022

Abstract
The paper considers the issues of preserving and expanding the reproduction of soil fertility for obtaining high yields of agricultural crops, identifies ways to solve the problem of ecologizing the agricultural landscape by introducing horny hoofed crumbs as an alternative to the mineral form of nitrogen fertilizer and zeolite-containing tripoli as a sorption-type soil improver, as in direct action, and aftereffect. The results of the study revealed the role of the applied fertilizers in increasing the leaf surface area of potato and fodder beet plants, led to an increase in the biological activity of the soil, contributed to the improvement of the quality indicators of the obtained products (dry matter content, nitrates), increased the productivity of cultivated row crops, as in the year of fertilization and endured, and in the aftereffect on barley. The conducted bioenergetic assessment of the studied fertilizers and zeolite-containing tripoli against the background of phosphorus-potassium mineral fertilizers determined the most effective options with the use of horn-hoofed crumbs and tripoli, both independently and when applied together.
Varietal agrotechnics of perennial grasses in the climate of Central Siberia
Authors: Lipshin Alexey G 
Published: February 2022

Abstract
The article presents the features of varietal agrotechnics of perennial grasses in the climate of Central Siberia. The technological features of cultivation are revealed - the requirements for soils, the main and pre-sowing soil cultivation, the use of fertilizers, the timing and methods of grassing, grass mixtures sowing, care for crops in the grassing year.
Efficiency of agrotechnical methods of cultivation of soybean for grain in different ecological zones of Western Siberia
Authors: Galeev Rinat R , Petrov Dmitrii D , Smirnov Anton E 
Published: February 2022

Abstract
The results of three-year studies (2019-2021) on the study of the effeciencyof growing different varieties of soybean for grain in the ecological zones of Western Siberia (forest-steppe, steppe) are presented. The experiments were carried out on leached chernozem of the Novosibirsk region, gray forest soil of the Novosibirsk region and the Tomsk region and Kulunda steppe of the Novosibirsk region. It has been established that in the forest-steppe of Western Siberia, in the production of soybean grain it is efficient to use varieties Omskaya 4, SibSFI 315, Gorinskaya, Krasnoobskaya, Avanta and Bara, providing a yield level of 2-3.5 t/ha. on leached chernozem and gray forest soil. Photosynthetic parameters (leaf area and Photosynthetic Potential (PSP)) were observed when sowing different varieties of soybeans of the Siberian selection SibSFI 315, Krasnoobskaya, Gorinskaya and Omskaya 4, especially when sowing in the third decade of May and with a seeding rate of 500 thousand pieces of viable seeds per hectare. It was found that the yield of soybean varieties is higher when sown in the third decade of May. It is statistically determined that the yield of soybean grain depended on the technology element by 36%, genotype - 23% and weather conditions - 21%. The efficiency of irrigation is shown at a level of moisture supply of 70-80% of the highest moisture capacity (HMC) in the arid steppe Kulunda zone of Western Siberia: an increase in yield is of 160-190%, the efficiency of fertilizer application against the background of irrigation increases by 45%.
The effect of natural salt with herbicidal activity on the agrochemical properties of soil and Cirsium Arvense
Authors: Ulyanova O A , Kurachenko N L , Vlasenko O A 
Published: February 2022

Abstract
In a field experiment, an assessment of the effect of solutions of natural salt with herbicidal activity on the agrochemical properties of ordinary chernozem and a phytocenosis heavily contaminated with pink thistle (Cirsium Arvense, Asteraceae family) was given. To study the mechanism of action of 20, 30 and 40% solutions of natural salt on the “plant-soil” system and changes in the chemical state of the soil, we used crude natural brines from the Troitsk deposit in the Krasnoyarsk Territory. The results of the research found that the use of various solutions of natural salt as a herbicide determined alkalinization of the soil by 0.2-0.3 units. pH while maintaining the neutral reaction of the soil solution and changing the composition of the salts of the aqueous extract. The control soil contained a high amount of humus. Treatment of plants with natural salt contributed to an increase in the indicator by 6-11%, depending on the concentration of the salt solution used. Common chernozem was characterized by a very low and low supply of mineral forms of nitrogen, a very high supply of exchangeable potassium and an increased and high supply of mobile phosphorus, depending on the variant of the experiment. When processing the pink thistle in the growing season before its flowering with solutions of salts of different concentrations, the biological efficiency of the solution of 20% concentration was 58%, and the treatment of this weed with 30 and 40% concentration of natural salt led to its death by - 82 and 88% to the control, respectively.
Assessment of export potential of the Russian agro-industrial complex
Authors: Dzhancharova G K , Ilyasov R H , Romadikova V M 
Published: February 2022

Abstract
The work is devoted to the assessment of Russian exports of agricultural products at the end of 2020. Record harvests in some segments of the agricultural industry allowed Russia not only to increase the volume of supplies of agricultural products to the world food markets, but also to actually open new promising markets in Africa, Asia and Europe. State programs to support Russian farmers will maximize the stimulation of production and development of this industry, not only in terms of increasing production volumes, but also in terms of creating rural infrastructure. The program to stimulate the export of agricultural products until 2024 allowed Russia to advance in the ranking of world exports to 20th place at the end of 2020. Further advancement of the position in the rating will depend on the structure of exports itself and the increase in the production of the processing industry in it. Forecasts for the growth of exports of the Russian agro-industrial complex are quite optimistic and will depend on a number of objective factors.
The role of morphological adaptation and variability of potato varieties in plants photosynthetic apparatus formation
Authors: Shitikova Aleksandra V , Abiala Aurel A , Povarnitsyna Anastasia V 
Published: February 2022

Abstract
When determining the duration of interphase periods, researchers are faced with a number of difficulties, such as flowering dates absence or delay, a weak correlation between flowering and tuberization, and death of the aboveground part of plants from diseases and pests. In regards to flowering, potatoes are a long-day plant, and according to tuberization - a short one, therefore, photoperiodism significantly affects the development of potato plants. Under conditions of a long day, the normal development of the above-ground plant mass occurs, while a change in photoperiodic conditions until a short day leads to plant’s above cessation growth -ground organs and the onset of enhanced tuberization. The duration of the interfacial periods is influenced by soil and climatic factors, such as heat and moisture supply; under the experimental conditions, the growing season was also determined by varietal characteristics. It should also be noted that the duration of the interphase periods depends on the agrotechnical measures. During the years of research, this indicator varied greatly and had an impact on the yield of the studied varieties. The article presents the results of 3-year studies on the adaptation of potato varieties to changing climatic conditions based on plant architectonics peculiarities research, systematization of new promising potato varieties according to ecological and morphological characteristics, allowing to control crop productivity, is carried out. The most productive in years with contrasting moisture availability were potato varieties, the mid-season variety of the xeromorphic ecomorphic type Kumach (35.7 t/ha), the hygromorphic ultra-early ripening variety Meteor (33.9 t/ha); mesomorphic mid-season varieties Barin (33.9 t/ha) and Resurs (32.3 t/ha). There was a positive correlation between the yield and the atLEAF parameters, the chlorophyll content was higher than the average values for the varieties by 1.8 - 6.2 units.
Sustainable development of organic farming like innovation element in the system of food security of the region
Authors: Kovaleva Irina , Kudinova Margarita , Shevchuk Natalya , Uvarova Elena 
Published: February 2022

Abstract
The ever-increasing interest in organic farming products on the part of consumers stimulates organic producers to expand their product range and search for new markets and distribution channels. Especially demanded organic products in European countries and the United States. Increased requirements for the production of organic matter presupposes the presence of certain conditions in terms of certification of lands, technologies and quality characteristics of organic products. This, in turn, requires a regulatory and legal framework at the state level, a certification system, including the rules and procedure for certification of land and products, organizations with the right to conduct accreditation procedures, pricing and possible preferences for small businesses and the private sector of the population. This will optimize the requirements for the phased passage of the certification procedure and serve as a stimulating element for attracting new producers of organic products. An equally important strategic problem is the organization of effective marketing channels for organic products. The relevance of food security and the availability of food are topical issues in Russia. In the agro-industrial multifaceted, issues related to low profitability of production, preservation of the genetic material of farm animals, and others have not been resolved. The main measures to increase the economic accessibility of food can be implemented through regional programs for sustainable development of country area One of the urgent problems of the world community is the development of organic farming and the formation of markets for organic products. At the same time, commodity differentiation of organic products and geographic segmentation are the main factors influencing the development of organic farming. The producers of organic products in Russia, as a rule, are small businesses. Development of organic farming is of particular importance for cross-border agro-oriented regions, since it contributes to the development of export activities and commodity diversification. For the Altai Territory, the development of organic farming makes it possible to effectively develop new areas of gastronomic and rural tourism.
Development of sustainable systems of food production of chopped semi-finished products
Authors: Alekseeva Y A , Khoroshailo T A , Bachinina K N , Martemyanova A A 
Published: February 2022

Abstract
Currently, the food industry is carried out with the use of food additives. Many world scientists are working on the formation of new nutritional supplements or improving existing supplements. There are nearly two thousand nutritional supplements around the world, and of course, there is a need to improve them. In the meat industry, additives developed according to their own recipe are used in the manufacture of products. The use of such additives depends on the purpose of the manufacturer. Skeptics argue that nutritional supplements are only needed to increase sales. The topic of the introduction of food additives, namely with a high content of vitamins, is very relevant in our time. Today, there is practically no food left, wherever nutritional supplements are used.
Intellectual assessment of staff sufficiency for innovative development of the sustainable regional agro-industrial complex
Authors: Lomazov V A , Yu Evsyukov D , Lomazova V A , Prokushev Ya E , Nesterova E V 
Published: February 2022

Abstract
The paper is devoted to the problems of assessment of staff sufficiency for regional economy agroindustrial sector’s innovative development. The proposed approach is based on the application of models and methods of expert assessment and digital intelligent technologies. The share of employees who are ready (professionally) to use innovations from the total number of employees was chosen as the main evaluation characteristic. At the same time, the indicators of staff sufficiency of subsystems and the sustainable regional agro-industrial complex as a whole are formed on the basis of statistical data provided by enterprises, expert judgments and knowledge about the subject area represented by a system of fuzzy production rules. The developed hierarchy of indicators reflects the structure of the regional agro-industrial complex (subcomplexes, reproduction and functional components, categories of enterprises). The transition to indicators of a higher tier of the hierarchy is realized based on the indicators of the previous tier, using weighted summation and/or fuzzy logical inference, which allows taking into account not only the relative importance of individual subsystems (components), but also the high level of uncertainty characteristic of the agro-industrial economy. At the same time, evaluation indicators of various tiers of the hierarchy can be used to make managerial decisions. Preliminary results of the application of the developed hierarchy of evaluation indicators of staffing of the sustainable regional agro-industrial complex and the proposed procedure for determining the values of these indicators may indicate the effectiveness of the proposed approach.