bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scaphometacarpal Stabilization Technique for Repairable Scapholunate Injury
Authors: Pajares S. , Gómez-Álvarez J. , Sola-Mallo X 
Published: June 2022

AbstractDespite the numerous techniques (both arthroscopic and open) for the treatment of acute scapholunate instability, there is no consensus on which one results in better healing of the ligaments. In the present work, we describe a new surgical technique to achieve stability of the scaphoid that enables the reduction inflexion and pronation of this bone when dissociation is produced. Using a high-strength suture wire with double cortical button anchor (Mini TightRope, Arthrex, Naples, FL, US, or MicroLink, Conmed, Largo, FL, US) stabilization of the scaphoid is achieved to protect ligament healing without the need for postoperative immobilization.
Congenital Radial Dysplasia
Authors: Becerra Manuel Méndez , D'Angelo Pamela Escalona , Pérez Magdalena Méndez 
Published: June 2022

AbstractRadial dysplasia (RD) is a congenital condition which can affect the entire upper limb, compromising multiple tissues, and it always features alterations in the thumb. It can be uni- or bilateral condition, the latter being very disabling. Treatment with manipulations, casts and/or orthoses is recommended for the least severe presentations of this disease. The surgical treatment is reserved for the most severe cases, and carpal centralization is the treatment of choice today. The most frequent complication of this intervention is the recurrence of the deformity. The patients submitted to the surgical treatment report a significant improvement in the cosmetic aspect of the extremity. The current challenge is to improve the follow-up and the use of functional assessment tools regarding the results.
Dorsal Wrist Ganglia: Influence of Arthroscopic Dorsal Capsulodesis – A Pilot Study
Authors: Ribau Melanie , Ribeiro Elisabete Fernanda Magalhães , Barros Cecília Alexandra Sá , Ribeiro Juvenália Martins , Varanda Pedro Miguel Sousa , Rodrigues Luis Filipe Pacheco 
Published: June 2022

Abstract
Background Dorsal wrist ganglia are the commonest soft tissue tumor in the upper extremity. Management with arthroscopic excision yields good results and few complications, but recurrence is still a matter of concern.
Purpose To address the influence of dorsal capsulodesis in postoperative results.
Patients and Methods Two groups with eight patients each were evaluated: group A – simple arthroscopic resection (SAR), and group B – arthroscopic resection combined with dorsal capsulodesis (ARDC).
Results The mean age of group A was of 36.10 ±  7.96 (range: 28–53) years, and that of group B was of 34.17 ±  29.60 (range 18–44) years. The duration of the follow-up was of 30.67 ±  13.90 (range: 13.45–53.55) months and 29.60 ±  16.80 (range 12.68–62.13) months, respectively. Both groups achieved a a significant decrease in the postoperative score on the Visual Analog Scale (VAS) (of around 2/10), and the scores on the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire were below 5/100. All the functional parameters (range of motion and strength) were above 80% on the contralateral side, with no differences between groups. More than 75% of the patients were completely satisfied. Group A (37.5%) had a significantly higher recurrence rate than that of group B (12.5%).
Conclusions In conclusion, SAR and ARDC provided good clinical results, with no significant differences. Dorsal capsulodesis resulted in an important decrease in the recurrence rate.
Level of Evidence Level III (Retrospective Comparative Study).
Composite Free Tissue Transfer for Reconstruction of Lower Extremity Tendon Injuries: A Systematic Review
Authors: Sayyed Adaah A. , Bekeny Jenna C. , Day Jonathan , Attinger Christopher E. , Fan Kenneth L. , Evans Karen K. 
Published: June 2022

Abstract
Background Tendon rupture with extensive soft tissue loss has few reconstructive options. Composite free tissue transfers including skin and tendon offer an attractive reconstructive approach. Unfortunately, most studies discussing them come from sparse case reports. We systematically assess evidence supporting composite flap use in single-stage reconstruction of lower extremity tendon and soft tissue defects.
Methods A systematic review was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. OvidMEDLINEqueried for records pertaining to the study question using Medical Subject Heading (MeSH) terms such as “lower extremity,” “tendon,” and “composite flap.” No limitations were placed on the year of publication, country of origin, or study size. Study characteristics and patient demographics were collected. Primary outcomes included:(1) defect location, composite flap characteristics;(2) return to ambulation;(3) joint range of motion;(4) patient satisfaction, and (5) complications.
Results In total, 29 articles examining 173 patients with lower extremity tendon defects and soft tissue loss were identified. Average age was 44.3 years (SD 17.5); most patients were male (n = 110, 66.3%). Achilles defect was mostly reported (n = 151, 86.8%), followed by patellar (n = 17, 9.8%) and other tendon defects (n = 6, 3.4%). Average tendon defect size was 8.4 cm (SD 4.0), average soft tissue loss was 80.2 cm2 (SD 40.0). Most employed composite flap was anterolateral thigh and fascia lata (ALT + FL) (n = 101, 58.0%). Most patients (n = 134, 99.3%) returned to ambulation in an average 123.1 days (SD 78.3). Average reconstructive joint degree of motion was 62.1 degrees compared with normal degree of motion 62.3 degrees. Patient-reported outcomes demonstrated increased satisfaction after reconstruction.
Conclusion Composite flaps effectively reconstruct a variety of tendon and soft tissue defects; the most reported flap is ALT + FL, which provides large flap territories and rapid healing in Achilles, patellar, and other tendon defects. In this review, patients with composite flaps demonstrated return to ambulation, minimal impairment in range of motion, and notable postoperative satisfaction.
Platelet Activation and Thrombosis in COVID-19
Authors: Iba Toshiaki , Wada Hideo , Levy Jerrold H. 
Published: June 2022

AbstractAlthough thrombosis frequently occurs in infectious diseases, the coagulopathy associated with COVID-19 has unique characteristics. Compared with bacterial sepsis, COVID-19-associated coagulopathy presents with minimal changes in platelet counts, normal prothrombin times, and increased D-dimer and fibrinogen levels. These differences can be explained by the distinct pathophysiology of the thromboinflammatory responses. In sepsis-induced coagulopathy, leukocytes are primarily responsible for the coagulopathy by expressing tissue factor, releasing neutrophil extracellular traps, multiple procoagulant substances, and systemic endothelial injury that is often associated with vasoplegia and shock. In COVID-19-associated coagulopathy, platelet activation is a major driver of inflammation/thrombogenesis and von Willebrand factor and platelet factor 4 are deeply involved in the pathogenesis. Although the initial responses are localized to the lung, they can spread systemically if the disease is severe. Since the platelets play major roles, arterial thrombosis is not uncommon in COVID-19. Despite platelet activation, platelet count is usually normal at presentation, but sensitive biomarkers including von Willebrand factor activity, soluble P-selectin, and soluble C-type lectin-like receptor-2 are elevated, and they increase as the disease progresses. Although the role of antiplatelet therapy is still unproven, current studies are ongoing to determine its potential effects.
Mother to Newborn Transmission of SARS-CoV-2 Infection: Evolution of Evidence in 1.5 Years of COVID-19 Pandemic
Authors: Gupta Arpit , Kamity Ranjith , Sharma Rishika , Caprio Martha , Mally Pradeep , Verma Sourabh 
Published: June 2022

Coronavirus disease 2019 (COVID-19) pandemic caused significant mortality and morbidity in people of all age groups worldwide. Given the uncertainty regarding the mode of transmission and potential effects of COVID-19 on pregnant mothers and their newborns, guidelines for taking care of maternal–newborn dyads have evolved tremendously since the pandemic began. There has been an enormous influx of published materials regarding the outcomes of mothers and newborns. Still, multiple knowledge gaps regarding comprehensive information about risk to the mothers and newborns exist, which need to be addressed. Current evidence suggests that mothers with symptomatic COVID-19 infection are at increased risk of severe illness during pregnancy, with a higher need for respiratory support and premature deliveries. Neonates born to mothers with COVID-19 are at increased risk of needing intensive care; however, most newborns do well after birth. As new mutant variants arise, we need to be cautious while proactively understanding any new evolving patterns. All leading health authorities strongly recommend COVID-19 vaccination before or during pregnancy to reduce the risk of maternal morbidities and benefit from passing antibodies to newborns prenatally and via breastmilk. Additionally, there are racial, ethnic, and socioeconomic disparities in outcomes and vaccination coverage for pregnant women. This article summarizes the rapidly evolving evidence for the last 1.5 years and aims to help health care professionals care for mothers with COVID-19 and their newborns.
Key Points
Design and research on tuning fork piezoelectric actuator based on stick-slip effect
Authors: Ji Hua-wei , Lv Bo , Li Yu-hui , Yang Fan , Qi An-qi , Wu Xin , Ni Jing 
Published: June 2022

Aiming at the problems of low output speed, large size, and difficult miniaturization of stacked and sandwich piezoelectric actuators, a patch-type tuning fork piezoelectric actuator model based on the stick-slip effect was designed, in which the dynamic theoretical analysis, the simulation optimization to determine the stator structure parameters, and the experimental research were carried out to obtain the stator structure parameters. The externally applied conditions (the influence model of excitation voltage, excitation frequency, and pre-pressure) on the performance output of piezoelectric actuators will promote the miniaturization and industrialization of tuning fork piezoelectric actuators in the next step. The simulation results show that the integrated output performance of the piezoelectric actuator is best when the angle of the tuning fork is 15°. After optimizing the stator chamfer to 2.5 and 4.5 mm, the tangential amplitude difference of the 15° tuning fork angle actuator is the smallest. The experimental results show that the output speed of the actuator is positively linearly related to the excitation voltage, the maximum output thrust is 8 N when the excitation voltage is 100 V, the excitation frequency is 20.1 kHz, the pre-pressure is 7.5 N, the phase difference of the excitation signal is π/2, and the output speed of the actuator can reach 116 mm/s.
Highly efficient A-site cation exchange in perovskite quantum dot for solar cells
Authors: Zhao Chenyu , Zhang Xuliang , Huang Hehe , Yuan Jianyu 
Published: June 2022

The mixed cation colloidal Cs1−XFAXPbI3 perovskite quantum dots (PQDs) obtained by cation exchange between CsPbI3 and FAPbI3 PQDs have been reported to exhibit enhanced photovoltaic performance. However, the cation exchange mechanism requires further in-depth investigation in terms of both material properties and device application. In this work, the impact of PQD weight ratio, PQD concentration, and host solvent polarity during cation exchange is comprehensively investigated for the first time. In addition, the whole exchange process under varying conditions is monitored by photoluminescence spectroscopy. As a result, we observe extremely fast cation exchange (∼20 min) under a condition at a CsPbI3/FAPbI3 PQD weight ratio of 1:1, a concentration of 70 mg/ml, and a host solvent using toluene. Moreover, we directly fabricate a PQD solar cell device using these obtained mixed cation Cs0.5FA0.5PbI3 PQDs and achieved an enhanced power conversion efficiency of 14.58%. We believe that these results would provide more insights into the cation exchange in emerging PQDs toward efficient photovoltaic fabrication and application.
A community-based organisation-led HIV self-testing program among men who have sex with men in China is cheaper and more effective than facility-based HIV testing: an economic evaluation
Authors: Huang Shanzi , Ong Jason J. , Dai Wencan , He Xi , Zhou Yi , Li Xiaofeng , Huang Liqun , Tang Weiming 
Published: June 2022

Background HIV self-testing (HIVST) is effective in improving the uptake of HIV testing among key populations. Complementary data on the economic evaluation of HIVST is critical for planning and scaling up HIVST. This study aimed to evaluate the cost of a community-based organisation (CBO)-led HIVST model implemented in China. Methods An economic evaluation was conducted by comparing a CBO-led HIVST model with a CBO-led facility-based HIV rapid diagnostics testing (HIV-RDT) model. The full economic cost, including fixed and variable cost, from a health provider perspective using a micro costing approach was estimated. We determined the incremental cost-effectiveness ratios of these two HIV testing models over a 2-year time horizon (i.e. duration of the programs), and reported costs using US dollars (2021). Results From January 2017 to December 2018, a total of 4633 men were tested in the HIVST model, and 1780 men were tested in the HIV-RDT model. The total number of new diagnoses was 155 for HIVST and 126 for the HIV-RDT model; the HIV test positivity was 3.3% (95% confidence interval (CI): 2.8–3.9) for the HIVST model and 7.1% (95% CI: 5.9–8.4) for the HIV-RDT model. The mean cost per person tested was USD10.38 for HIVST and USD41.45 for HIV-RDT. The mean cost per diagnosed person was USD310.12 for HIVST compared with USD585.58 for HIV-RDT. Conclusion Compared to facility-based HIV-RDT, a CBO-led HIVST program is cheaper and more effective among MSM living in China.
Passage of exogeneous fine particles from the lung into the brain in humans and animals
Authors: Qi Yu , Wei Shuting , Xin Tao , Huang Chuanjiang , Pu Yichen , Ma Jinzhu , Zhang Changbin , Liu Yajun , Lynch Iseult , Liu Sijin 
Published: June 2022

There are still significant knowledge gaps in understanding the intrusion and retention of exogeneous particles into the central nervous system (CNS). Here, we uncovered various exogeneous fine particles in human cerebrospinal fluids (CSFs) and identified the ambient environmental or occupational exposure sources of these particles, including commonly found particles (e.g., Fe- and Ca-containing ones) and other compositions that have not been reported previously (such as malayaite and anatase TiO
2
), by mapping their chemical and structural fingerprints. Furthermore, using mouse and in vitro models, we unveiled a possible translocation pathway of various inhaled fine particles from the lung to the brain through blood circulation (via dedicated biodistribution and mechanistic studies). Importantly, with the aid of isotope labeling, we obtained the retention kinetics of inhaled fine particles in mice, indicating a much slower clearance rate of localized exogenous particles from the brain than from other main metabolic organs. Collectively, our results provide a piece of evidence on the intrusion of exogeneous particles into the CNS and support the association between the inhalation of exogenous particles and their transport into the brain tissues. This work thus provides additional insights for the continued investigation of the adverse effects of air pollution on the brain.
FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis
Authors: Zhu Xiaolong , Qiu Cong , Wang Yiran , Jiang Yuanqing , Chen Yefeng , Fan Linge , Ren Ruizhe , Wang Yunyun , Chen Yu , Feng Yanzhi , Zhou Xiaofei , Zhu Yunhui , Ge Zhen , Lai Dongwu , Qin Lingfeng , Simons Michael , Yu Luyang 
Published: June 2022

Angiogenesis contributes fundamentally to embryonic development, tissue homeostasis, and wound healing. Basic fibroblast growth factor (FGF2) is recognized as the first proangiogenic molecule discovered, and it facilitates angiogenesis by activating FGF receptor 1 (FGFR1) signaling in endothelial cells. However, the precise roles of FGFR and the FGF/FGFR signaling axis in angiogenesis remain unclear, especially because of the contradictory phenotypes of in vivo FGF and FGFR gene deficiency models. Our previous study results suggested a potential role of posttranslational small ubiquitin-like modifier modification (SUMOylation), with highly dynamic regulatory features, in vascular development and disorder. Here, we identified SENP1-regulated endothelial FGFR1 SUMOylation at conserved lysines responding to proangiogenic stimuli, while SENP1 functioned as the deSUMOylase. Hypoxia-enhanced FGFR1 SUMOylation restricted the tyrosine kinase activation of FGFR1 by modulating the dimerization of FGFR1 and FGFR1 binding with its phosphatase PTPRG. Consequently, it facilitated the recruitment of FRS2α to VEGFR2 but limited additional recruitment of FRS2α to FGFR1, supporting the activation of VEGFA/VEGFR2 signaling in endothelial cells. Furthermore, SUMOylation-defective mutation of FGFR1 resulted in exaggerated FGF2/FGFR1 signaling but suppressed VEGFA/VEGFR2 signaling and the angiogenic capabilities of endothelial cells, which were rescued by FRS2α overexpression. Reduced angiogenesis and endothelial sprouting in mice bearing an endothelial-specific, FGFR1 SUMOylation-defective mutant confirmed the functional significance of endothelial FGFR1 SUMOylation in vivo. Our findings identify the reversible SUMOylation of FGFR1 as an intrinsic fine-tuned mechanism in coordinating endothelial angiogenic signaling during neovascularization; SENP1-regulated FGFR1 SUMOylation and deSUMOylation controls the competitive recruitment of FRS2α by FGFR1 and VEGFR2 to switch receptor-complex formation responding to hypoxia and normoxia angiogenic environments.
Clean room, uncomfortable bed
Authors: Smirnova Elizaveta 
Published: June 2022

AbstractOnline customer reviews, being an essential factor that determines success or failure in business, in particular in the tourism industry, demand close attention since the investigation of this type of discourse might bear some implications both for language specialists and for hotel managers. This paper is a quantitative and qualitative study of evaluation devices occurring in the corpus of hotel reviews fromBooking.com. The analysis is based on methods associated with corpus linguistics and Systemic Functional Linguistics (Halliday 1994;Eggins 2004), specifically, the Appraisal framework (Martin & White 2005), which is applied here to a new type of discourse, that of hotel ratings. The study focuses on the categories of Attitude, Graduation and Engagement suggested by Martin and White and investigates inscribed and invoked evaluation. In order to adapt the Attitude dimensions to the corpus under study, new subcategories were created as a contribution to evaluation theory. The practical result of the study is a list of evaluation devices employed in hotel reviews; the list may be useful for further corpus analyses and for designing systems for automated analysis of customer evaluation. Since online customer reviews are commonly used by hotels as a benchmark of their guests’ satisfaction and a valuable information source of features and services that need to be improved, the present study is also likely to make an important contribution to the industry.
Investigation of support transducer enabled higher-order radial bulk mode MEMS resonator and low phase noise oscillator
Authors: Sharma Kongbrailatpam Sandeep , Jen Hsin-Tung , Li Sheng-Shian , Pillai Gayathri 
Published: June 2022

Abstract
This work reports the successful excitation of a novel bulk acoustic mode whose actuation and sensing are facilitated by the support transducer topology (STT). The design methodology concurrently supports low motional impedance and high energy confinement features which are crucial for frequency reference components in Radio Frequency communication. A conventional bulk mode operating in the width extension (WE) mode is deployed to efficiently excite the higher-order radial mode using the STT design feature of resonant frequency matching. The thin-film piezoelectric on substrate support transducers excited in a WE mode is mechanically coupled to the bulk silicon allowing the acoustic energy of the MEMS resonator to be stored maximally in the high-quality factor (Q) resonant tank, thereby alleviating the overall losses due to low-Q of the piezoelectric thin film and electrode material. The resonator exhibits a Q of 19 728 at 63.56 MHz resonant frequency with a motional resistance (R
m) of 368 Ω when measured in vacuum at a power level of 0 dBm. Under cryogenic measurement conditions, the device recorded a Q of 24 153 at 15 K. A standalone WE resonator is studied to put a spotlight on the quality factor enhancement technique using the STT. The STT enabled novel bulk mode enhances the overall Q by 320% and halves the R
m. When implemented as an oscillator, its performance exceeds the Global System for Mobile communication standards phase noise (PN) requirements. PN of −136.95 dBc Hz−1 and −161.52 dBc Hz−1 at 1 kHz and 1 MHz offset, respectively, were recorded when normalized to a carrier frequency of 13 MHz.
Nanoparticle-enhanced multifunctional nanocarbons—recent advances on electrochemical energy storage applications
Authors: Ghosh Subrata , Polaki S R , Macrelli Andrea , Casari Carlo S , Barg Suelen , Jeong Sang Mun , Ostrikov Kostya (Ken) 
Published: June 2022

Abstract
As renewable energy is becoming a crucial energy source to meet the global demand, electrochemical energy storage devices become indispensable for efficient energy storage and reliable supply. The electrode material is the key factor determining the energy storage capacity and the power delivery of the devices. Carbon-based materials, specifically graphite, activated carbons etc, are extensively used as electrodes, yet their low energy densities impede the development of advanced energy storage materials. Decoration by nanoparticles of metals, metal oxides, nitrides, carbides, phosphides, chalcogenides and bimetallic components is one of the most promising and easy-to-implement strategies to significantly enhance the structural and electronic properties, pore refinement, charge storage and charge-transfer kinetics of both pristine and doped carbon structures, thereby making their performance promising for next-generation energy storage devices. Structuring the materials at nanoscale is another probable route for better rate performance and charge-transfer kinetics. This review covers the state-of-art nanoparticle decorated nanocarbons (NCs) as materials for battery anode, metal-ion capacitor anode and supercapacitor electrode. A critical analysis of the elemental composition, structure, associated physico-chemical properties and performance relationships of nanoparticle-decorated NC electrodes is provided as well to inform the future development of the next-generation advanced energy storage materials and devices.