bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract PO-249: Prostate screening & patient knowledge on PSA testing among males: Analysis of the 2019 NHIS
Authors: Bumanlag Isabela M. , Nieves-Jimenez Humberto R. , Jaoude Joseph Abi , Ludmir Ethan B. , Taniguchi Cullen M. 
Published: January 2022

Abstract
Intro: Prostate cancer, one of the most common cancers for males, continues to have non-standardized screening with Prostate Specific Antigen (PSA) due to the potential risks and uncertainties that PSA screening can pose. Methods: The purpose of this study is to investigate the knowledge base of participants regarding the advantages and disadvantages of PSA screening. Using the 2019 National Health Interview Survey, we performed descriptive statistics on participant demographics and prostate screening questions. Bivariate and multivariable logistic regression was utilized to highlight variables that were associated with whether or not a doctor explained to a participant the advantages and disadvantages of PSA testing. Results: Overall, we gathered answers from 10,165 respondents aged 40 years or older, from a total of 31,997 participants in the 2019 NHIS survey. Nearly half of respondents (5004, 49.2%) reported that they had undergone a PSA test in the past and 38.6% of respondents reported that a doctor had discussed the advantages of a PSA test. On the other hand, only 25.8% reported that a doctor had discussed possible disadvantages of PSA testing. Our stratified analyses found that Asians were less likely to report that a doctor had discussed the advantages of a PSA test (OR = 0.59, P &lt; 0.05). We also found that the higher the educational status of a participant, the more likely a participant would report that a doctor talked about the advantages of a PSA test (high school graduates, OR = 1.83, P&lt;0.05; college degrees, OR = 2.48, P &lt; 0.05). Those without any form of health insurance coverage were less likely to be told about the advantages of PSA testing (OR = 0.60, P&lt; 0.05). Similar values in each of these covariates were also found to be statistically significant when participants were asked if a doctor had talked to them about the disadvantages of a PSA test. Conclusions: We found disparities of prostate cancer screening education based on social factors, which reinforce concerns of disparate access of information provided by physicians on the advantages and disadvantages of a PSA testing. Our findings support a call for the improvement of adequate patient-doctor discussions that fully address the risks and benefits of PSA testing.
Citation Format: Isabela M. Bumanlag, Humberto R. Nieves-Jimenez, Joseph Abi Jaoude, Ethan B. Ludmir, Cullen M. Taniguchi. Prostate screening & patient knowledge on PSA testing among males: Analysis of the 2019 NHIS [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-249.
Abstract PO-251: Cervical screening in Latinas of 20-24 years old: findings from the Brazilian cervical cancer information system
Authors: Correa Tulio L. , Garcez Valquiria P. , Guelli Mariana S.T.C. , Cruz Carolina C. , Lara Julia P. , e Silva Matheus M.C. , Rodrigues Luana O. , Guglielmelli Isabel C. , Giordani Betina M 
Published: January 2022

Abstract
Introduction: The Brazilian National Cancer Institute attests that cervical cancer screening should be performed once a year in women aged 25 to 64 years, then every three years after two consecutive negative exams. However, the first sexual activity in Latinas usually occurs in late adolescence, between 15 to 19 years old. Therefore, the aim of this study was to evaluate cervical cytopathological changes with suspected malignancy and/or high potential for progression to malignancy in Brazilian women of 20 to 24 years old. Methods: Cross-sectional, descriptive study which evaluated cervical smears with satisfactory sampling obtained in Brazil from 2006 to 2015 using data from the national database (SISCOLO – Brazilian Cervical Cancer Information System). Suspected malignancy or high potential for progression to malignancy was composed of: high-grade indeterminate squamous cell, high-grade indeterminate glandular cell, high-grade cell of indefinite origin, high-grade intraepithelial lesion, intraepithelial lesion with micro-invasion, invasive squamous cell carcinoma, adenocarcinoma in situ, invasive adenocarcinoma, and other neoplasms. Results: During this time period, 86 375 132 cervical screening tests with satisfactory sampling were performed in the country, with 862,875 (1%) having abnormal results suggestive of suspected malignancy or high potential for progression to malignancy. Of the tests with abnormal results, 704,886 (82%) were from the age group of 25 to 64 years and 69,035 (8%) were from the age group of 20 to 24 years. From 2006 to 2015, there was a decrease of 53% in the total number of cervical cancer screening tests performed in Brazil. Conclusion: In our study, a significant percentage of the abnormal test results were from Latinas of 20 to 24 years old. The precociousness of sexual initiation and the multiplicity of sexual partners can expose women to human papillomavirus at a very early age, which may explain the findings reported.
Citation Format: Tulio L. Correa, Valquiria P. Garcez, Mariana S.T.C. Guelli, Carolina C. Cruz, Julia P. Lara, Matheus M.C. e Silva, Luana O. Rodrigues, Isabel C. Guglielmelli, Betina M Giordani. Cervical screening in Latinas of 20-24 years old: findings from the Brazilian cervical cancer information system [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-251.
Abstract PR-17: The role of HMGA2 and CLK3 in prostate cancer health disparities
Authors: Campbell Taaliah , Hawsawi Ohuod , Odero-Marah Valerie 
Published: January 2022

Abstract
African American men (AA) suffer disproportionately from prostate cancer (PCa) displaying higher incidence and mortality rates when compared to Caucasian-American men (CA). Recent studies have shown that high mobility group A2 (HMGA2), a non-histone chromatin binding protein, plays a critical role in promoting metastasis. HMGA2 full-length/wild-type and truncated (lacking the 3'UTR) isoforms are overexpressed in several cancers, however, their distinct roles in PCa have not been reported. Literature has previously revealed a splicing factor, CDC-like kinase 3 (CLK3), that promotes splicing of wild-type HMGA2 to create the truncated HMGA2 isoform. We hypothesize that HMGA2 isoforms may play differential roles to promote PCa progression according to ethnicity. qPCR analysis of patient tissue of varying PCa stages was conducted to look at the mRNA expression of HMGA2 isoforms and CLK3. RNA-Seq was performed on LNCaP prostate cancer cell lines stably overexpressing wild-type or truncated HMGA2 and compared to Neo control. Both wild-type and truncated HMGA2 increased with increased PCa gleason grade. AA when compared to CA, displayed higher levels of truncated HMGA2 and its splicing factor, CLK3. RNA-Seq analysis revealed distinct gene sets regulated by truncated HMGA2 compared to wild-type HMGA2, including upregulation of a distinct set of genes involved in androgen signaling. These results indicate that HMGA2 isoforms are disproportionately expressed in AA and CA and increase with PCa progression. The regulation of differential genes by HMGA2 isoforms suggest that they may use distinct pathways to promote PCa.
Citation Format: Taaliah Campbell, Ohuod Hawsawi, Valerie Odero-Marah. The role of HMGA2 and CLK3 in prostate cancer health disparities [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PR-17.
Dostoïevski face à l’altérité, entre lecture bakhtinienne et interprétation lévinassienne. Notes sur Dostoïevski. La Question de l’autre, de Jacques Rolland
Authors: Colin Yoann 
Published: January 2022

Il s’agit d’examiner le livre de Jacques Rolland Dostoïevski. La Question de l’autre, parce qu’il propose un éclairage original et fécond sur ce qu’il y a de philosophique dans les grands romans dostoïevskiens, sans sombrer sur l’écueil qui consiste à réduire ces romans à des concepts. Il en ressort une analyse précise de l’altérité, questionnement central dans ces romans, où se mêlent les influences de Levinas, Bakhtine, Catteau et du christianisme.
Association of Alcohol Use Diagnostic Codes in Pregnancy and Offspring Conotruncal and Endocardial Cushion Heart Defects
Authors: Harvey Drayton C. , Baer Rebecca J. , Bandoli Gretchen , Chambers Christina D. , Jelliffe‐Pawlowski Laura L. , Kumar S. Ram 
Published: January 2022

Background
The pathogenesis of congenital heart disease (CHD) remains largely unknown, with only a small percentage explained solely by genetic causes. Modifiable environmental risk factors, such as alcohol, are suggested to play an important role in CHD pathogenesis. We sought to evaluate the association between prenatal alcohol exposure and CHD to gain insight into which components of cardiac development may be most vulnerable to the teratogenic effects of alcohol.

Methods and Results

This was a retrospective analysis of hospital discharge records from the California Office of Statewide Health Planning and Development and linked birth certificate records restricted to singleton, live‐born infants from 2005 to 2017. Of the 5 820 961 births included, 16 953 had an alcohol‐related
International Classification of Diseases
, Ninth and Tenth Revisions (ICD‐9; ICD‐10
)
code during pregnancy. Log linear regression was used to calculate risk ratios (RR) for CHD among individuals with an alcohol‐related
ICD
‐9 and ICD10
code during pregnancy versus those without. Three models were created: (1) unadjusted, (2) adjusted for maternal demographic factors, and (3) adjusted for maternal demographic factors and comorbidities. Maternal alcohol‐related code was associated with an increased risk for CHD in all models (RR, 1.33 to 1.84); conotruncal (RR, 1.62 to 2.11) and endocardial cushion (RR, 2.71 to 3.59) defects were individually associated with elevated risk in all models.

Conclusions
Alcohol‐related diagnostic codes in pregnancy were associated with an increased risk of an offspring with a CHD, with a particular risk for endocardial cushion and conotruncal defects. The mechanistic basis for this phenotypic enrichment requires further investigation.
Trends in the Incidence of New‐Onset Hypertensive Disorders of Pregnancy Among Rural and Urban Areas in the United States, 2007 to 2019
Authors: Cameron Natalie A. , Everitt Ian , Seegmiller Laura E. , Yee Lynn M. , Grobman William A. , Khan Sadiya S. 
Published: January 2022

Background
Hypertensive disorders of pregnancy are growing public health problems that contribute to maternal morbidity, mortality, and future risk of cardiovascular disease. Given established rural‐urban differences in maternal cardiovascular health, we described contemporary trends in new‐onset hypertensive disorders of pregnancy in the United States.

Methods and Results
We conducted a serial, cross‐sectional analysis of 51 685 525 live births to individuals aged 15 to 44 years from 2007 to 2019 using the Centers for Disease Control and Prevention Natality Database. We included gestational hypertension and preeclampsia/eclampsia in individuals without chronic hypertension and calculated the age‐adjusted incidence (95% CI) per 1000 live births overall and by urbanization status (rural or urban). We used Joinpoint software to identify inflection points and calculate rate of change. We quantified rate ratios to compare the relative incidence in rural compared with urban areas. Incidence (95% CI) of new‐onset hypertensive disorders of pregnancy increased from 2007 to 2019 in both rural (48.6 [48.0–49.2] to 83.9 [83.1–84.7]) and urban (37.0 [36.8–37.2] to 77.2 [76.8–77.6]) areas. The rate of annual increase in new‐onset hypertensive disorders of pregnancy was more rapid after 2014 with greater acceleration in urban compared with rural areas. Rate ratios (95% CI) comparing incidence of new‐onset hypertensive disorders of pregnancy in rural and urban areas decreased from 1.31 (1.30–1.33) in 2007 to 1.09 (1.08–1.10) in 2019.

Conclusions
Incidence of new‐onset hypertensive disorders of pregnancy doubled from 2007 to 2019 with persistent rural‐urban differences highlighting the need for targeted interventions to improve the health of pregnant individuals and their offspring.
On the Neuronal Dynamics of Aesthetic Experience: Evidence from Electroencephalographic Oscillatory Dynamics
Authors: Strijbosch Wim , Vessel Edward A. , Welke Dominik , Mitas Ondrej , Gelissen John , Bastiaansen Marcel 
Published: January 2022

Abstract
Aesthetic experiences have an influence on many aspects of life. Interest in the neural basis of aesthetic experiences has grown rapidly in the past decade, and fMRI studies have identified several brain systems supporting aesthetic experiences. Work on the rapid neuronal dynamics of aesthetic experience, however, is relatively scarce. This study adds to this field by investigating the experience of being aesthetically moved by means of ERP and time–frequency analysis. Participants' EEG was recorded while they viewed a diverse set of artworks and evaluated the extent to which these artworks moved them. Results show that being aesthetically moved is associated with a sustained increase in gamma activity over centroparietal regions. In addition, alpha power over right frontocentral regions was reduced in high- and low-moving images, compared to artworks given intermediate ratings. We interpret the gamma effect as an indication for sustained savoring processes for aesthetically moving artworks compared to aesthetically less-moving artworks. The alpha effect is interpreted as an indication of increased attention for aesthetically salient images. In contrast to previous works, we observed no significant effects in any of the established ERP components, but we did observe effects at latencies longer than 1 sec. We conclude that EEG time–frequency analysis provides useful information on the neuronal dynamics of aesthetic experience.
Episodic Memory Precision and Reality Monitoring Following Stimulation of Angular Gyrus
Authors: Kwon Simon , Richter Franziska R. , Siena Michael J. , Simons Jon S. 
Published: January 2022

Abstract
The qualities of remembered experiences are often used to inform “reality monitoring” judgments, our ability to distinguish real and imagined events. Previous experiments have tended to investigate only whether reality monitoring decisions are accurate or not, providing little insight into the extent to which reality monitoring may be affected by qualities of the underlying mnemonic representations. We used a continuous-response memory precision task to measure the quality of remembered experiences that underlie two different types of reality monitoring decisions: self/experimenter decisions that distinguish actions performed by participants and the experimenter and imagined/perceived decisions that distinguish imagined and perceived experiences. The data revealed memory precision to be associated with higher accuracy in both self/experimenter and imagined/perceived reality monitoring decisions, with lower precision linked with a tendency to misattribute self-generated experiences to external sources. We then sought to investigate the possible neurocognitive basis of these observed associations by applying brain stimulation to a region that has been implicated in precise recollection of personal events, the left angular gyrus. Stimulation of angular gyrus selectively reduced the association between memory precision and self-referential reality monitoring decisions, relative to control site stimulation. The angular gyrus may, therefore, be important for the mnemonic processes involved in representing remembered experiences that give rise to a sense of self-agency, a key component of “autonoetic consciousness” that characterizes episodic memory.
Demagogues and Demagoguery in Hellenistic Greece
Authors: Simonton Matt 
Published: January 2022

Abstract
This paper introduces scholars of Greek political thought to the continued existence of the phenomenon of demagoguery, or ‘(mis-)leadership of the people’, in the Hellenistic period. After summarizing Classical elite discourse about demagoguery, I explore three areas in which political leaders continued to run afoul of elite norms in Hellenistic democratic poleis: 1) political persecution of the wealthier members of a political community; 2) ‘pandering to’ the people in a way considered infra dignitatem; and 3) stoking bellicosity among the common people. I show that considerable continuities link the Classical and Hellenistic periods and that demagoguery should be approached as a potential window onto ‘popular culture’ in Greek antiquity.
Odd, Idle, and Vicious: Plato’s Use of Public Opinion in His Characterization of the Philosopher in Republic VI
Authors: Silva Trinidad 
Published: January 2022

Abstract
Plato’s characterization of the philosopher often emerges as a way to respond to popular conceptions and representations of the intellectual in Athenian society. In book 6 of the Republic in particular, he articulates his greatest defense of the philosopher against two major charges – that of being vicious and useless. Voicing what appears to be a commonly held view among Athenians, this representation of the philosopher is raised by Adeimantus as an objection to Socrates’ proposal of a philosopher-king. Surprisingly, rather than dismissing the allegations as false, Socrates admits ‘that what they say is true’ (Resp. 6.487d10) and incorporates these criticisms into his argument. This paper proposes that the popular depiction of the philosopher as odd, vicious and idle plays a significant role in Plato’s own characterization of the philosopher, illustrating how Plato diagnoses the philosopher’s alienation from public affairs in a manner that defines and legitimates his own ideas of philosophy.
Gangrenous Cholecystitis From Gallbladder Volvulus With a Hiatal Hernia
Authors: Armistead Charles W. , Favors Lauren E. , Mejia Vincente A. 
Published: January 2022

Gallbladder volvulus is a rare condition involving the rotation of the gallbladder about the cystic duct and vascular pedicle, compromising biliary drainage and blood flow. This report describes a case of gallbladder volvulus presenting in an 88-year-old female with acute onset of right upper quadrant abdominal pain, nausea, and vomiting. Complete work-up included a physical exam, laboratory studies, and computed tomography (CT), which was notable for a markedly distended gallbladder with circumferential wall thickening, pericholecystic fluid, a 12 mm common bile duct, and a hiatal hernia. Given that her initial presentation was consistent with acute cholecystitis, we elected to perform laparoscopic cholecystectomy. The definitive diagnosis of gallbladder volvulus was made intraoperatively after decompression of the gallbladder and visualization of counterclockwise rotation of the gallbladder around the hilum and the infundibulum. This case illustrates the challenge in preoperative diagnosis of gallbladder volvulus, which requires high clinical suspicion to provide prompt surgical intervention.
Are Immigrants Scapegoats? The Reciprocal Relationships Between Subjective Well-Being, Political Distrust, and Anti-immigrant Attitudes in Young Adulthood
Authors: Korol Liliia , Fietzer Alexander W. , Bevelander Pieter , Pasichnyk Ihor 
Published: January 2022

This study examined the impact of native youth’s subjective well-being on exclusionary attitudes toward immigrants, seeking to understand the relationship between subjective well-being, political distrust, and anti-immigrant attitudes over time. Using longitudinal data, we followed three cohorts of native young adults ( N = 1352; Mage = 22.72, SD = 3.1) in Sweden over a period of 2 years. The results showed that subjective well-being did not predict an increase in anti-immigrant attitudes among native youth, but anti-immigrant attitudes had a significant impact on subjective well-being. The data also found bidirectional and mutually reinforcing relationships between subjective well-being and political distrust, and between political distrust and anti-immigrant attitudes. These results highlight that improving young adults’ subjective well-being represents an important basis for preventing the development of political distrust, which in turn could reduce native youth’s susceptibility to adopt hostile attitudes toward immigrants.
Association of Pediatric Hearing Quality and Sports Participation: A Population‐Based Study
Authors: Kozin Elliott D. , Knoll Renata M. , Bhattacharyya Neil 
Published: January 2022

Sports‐related injuries, such as concussion, during childhood may result in considerable morbidity, including a range of negative developmental consequences. Auditory dysfunction is generally recognized to be a possible sequela of sports‐related concussion; however, few epidemiologic studies have quantified the association between hearing quality and sports‐related activity in the pediatric population. The National Health and Nutrition Examination Survey for the 2015‐2016 cycle was utilized to determine the association of sports activities and hearing quality. Subjective abnormal hearing quality was more frequent among children who played football than those that did not (36.5% vs 26.8%; odds ratio, 1.56 [95% CI, 1.23‐2.00]; P =. 001). Other sports, such as basketball and soccer, did not have this association with hearing quality (P =. 496 and P =. 852, respectively). Our findings suggest a notable association between practice of a potentially high concussion sport and hearing quality. Children practicing football are 1.56 times more likely to report abnormal hearing quality.Level of Evidence: 4.
C-reactive protein to albumin ratio provides important long-term prognostic information in patients undergoing endovascular abdominal aortic repair
Authors: Demirci Gökhan , Demir Ali Riza , Uygur Begüm , Bulut Umit , Avci Yalcin , Tükenmez Karakurt Seda , Memiç Sancar Kadriye , Aktemur Tugba , Ersoy Burak , Celik Omer , Erturk Mehmet 
Published: January 2022

Background The prognostic value of C-reactive protein/albumin ratio (CAR) is of import in cardiovascular diseases. Our aim was to evaluate the impact of the CAR in patients with asymptomatic abdominal aortic aneurysm (AAA) undergoing endovascular aneurysm repair (EVAR). Material and Method We retrospectively evaluated 127 consecutive patients who underwent technically successful elective EVAR procedure between December 2014 and September 2020. The optimal CAR cut-off value was determined by using receiver operating characteristic (ROC) curve analysis. Based on the cut-off value, we investigated the association of CAR with long-term all-cause mortality. Results 32 (25.1%) of the patients experienced all-cause mortality during a mean 32.7 ± 21.7 months’ follow-up. In the group with mortality, CAR was significantly higher than in the survivor group (4.63 (2.60–11.88) versus 1.63 (0.72–3.24), p < 0.001). Kaplan–Meier curves showed a higher incidence of all-cause mortality in patients with high CAR compared to patients with low CAR (log-rank test, p < 0.001). Multivariable Cox regression analysis revealed that glucose ≥ 110 mg/dL (HR: 2.740; 95% CI: 1.354–5.542; p = 0.005), creatinine ≥ 0.99 mg/dL (HR: 2.957, 95% CI: 1.282–6.819, p = 0.011) and CAR > 2.05 (HR: 8.190, 95% CI: 1.899–35.320, p = 0.005) were the independent predictors of mortality. Conclusion CAR was associated with a significant increase in postoperative long-term mortality in patients who underwent EVAR. Preoperatively calculated CAR can be used as an important prognostic factor.