bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental observation of periodic Korteweg-de Vries solitons along a torus of fluid
Authors: Novkoski Filip , Pham Chi-Tuong , Falcon Eric 
Published: August 2022

Abstract
We report on the experimental observation of solitons propagating along a torus of fluid. We show that such a periodic system leads to significant differences compared to the classical plane geometry. In particular, we highlight the observation of subsonic elevation solitons, and a nonlinear dependence of the soliton velocity on its amplitude. The soliton profile, velocity, collision, and dissipation are characterized using high-resolution space-time measurements. By imposing periodic boundary conditions onto the Korteweg-de Vries (KdV) equation, we recover these observations. A nonlinear spectral analysis of solitons (periodic inverse scattering transform) is also implemented and experimentally validated in this periodic geometry. Our work thus reveals the importance of periodicity for studying solitons and could be applied to other fields involving periodic systems governed by a KdV equation.
MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons
Authors: Tang Elizabeth I , Cheng C Yan 
Published: August 2022

Abstract
Microtubule affinity-regulating kinases (MARKs) are nonreceptor Ser/Thr protein kinases known to regulate cell polarity and microtubule dynamics in Caenorhabditis elegans, Drosophila, invertebrates, vertebrates, and mammals. An earlier study has shown that MARK4 is present at the ectoplasmic specialization and blood-testis barrier (BTB) in the seminiferous epithelium of adult rat testes. Here, we report the function of MARK4 and another isoform MARK2 in Sertoli cells at the BTB. Knockdown of MARK2, MARK4, or MARK2 and MARK4 by RNAi using the corresponding siRNA duplexes without apparent off-target effects was shown to impair tight junction (TJ)-permeability barrier at the Sertoli cell BTB. It also disrupted microtubule (MT)- and actin-based cytoskeletal organization within Sertoli cells. Although MARK2 and MARK4 were shown to share sequence homology, they likely regulated the Sertoli cell BTB and MT cytoskeleton differently. Disruption of the TJ-permeability barrier following knockdown of MARK4 was considerably more severe than loss of MARK2, though both perturbed the barrier. Similarly, loss of MARK2 affected MT organization in a different manner than the loss of MARK4. Knockdown of MARK2 caused MT bundles to be arranged around the cell periphery, whereas knockdown of MARK4 caused MTs to retract from the cell edge. These differences in effects on the TJ-permeability barrier are likely from the unique roles of MARK2 and MARK4 in regulating the MT cytoskeleton of the Sertoli cell.
Extracranial-to-Intracranial Bypass for Distal Internal Carotid Artery and/or Proximal Middle Cerebral Artery Steno-Occlusive Disease: A Case Series of Clinical Outcomes at a Single, High-Volume Cerebrovascular Center
Authors: Housley Steven B. , Vakharia Kunal , Gong Andrew D. , Waqas Muhammad , Rho Kyungduk , Levy Elad I. , Davies Jason M. , Siddiqui Adnan H. 
Published: August 2022

BACKGROUND:
Extracranial-to-intracranial (EC–IC) bypass was first described by Yasargil in the 1960s for treatment of symptomatic distal internal carotid artery (ICA) and/or proximal middle cerebral artery (MCA) steno-occlusive disease through direct anastomosis. Subsequent bypass trials failed to demonstrate benefit for overall outcomes and stroke rates compared with best medical therapy. However, the procedure remained in the neurosurgeon's armament, with studies showing benefits in select patient populations. With advancements in technology, patient selection has become more comprehensive.

OBJECTIVE:
To provide a contemporary evaluation of EC–IC bypass from our high-volume cerebrovascular center, focusing on associated clinical outcomes.

METHODS:
Consecutive patients who underwent direct EC–IC bypass surgeries for symptomatic distal ICA and/or proximal MCA steno-occlusive disease between April 2015 and September 2019 were identified retrospectively. Medical records were reviewed to collect demographics, clinical presentation, computed tomography perfusion imaging findings, transcranial Doppler results, procedure indication, donor vessel types, anastomosis site, bypass patency, periprocedural complications, postprocedural complications, symptom recrudescence, repeat or new interventions, subjective improvements, and modified Rankin Scale scores.

RESULTS:
We identified 27 patients who underwent 32 EC–IC bypass procedures. The rate of ipsilateral stroke was 9.4%, with a median follow-up of 8 months (IQR, 4-13 months). Patients experienced a 22.3% improvement in modified Rankin Scale scores, and 70.3% of patients reported subjective improvement and satisfaction at follow-up.

CONCLUSION:
Direct EC–IC bypass remains a viable option for revascularization in symptomatic patients with distal ICA and/or proximal MCA steno-occlusive disease.
Novel Use of the Aurora Surgiscope System for Minimally Invasive Resection of Intraparenchymal Lesions: A Case Series
Authors: Achey Rebecca L. , Soni Pranay , Kashkoush Ahmed , Davison Mark , Kondylis Efstathios , Moore Nina , Bain Mark 
Published: August 2022

BACKGROUND:
Minimally invasive surgery (MIS) for intracranial pathology minimizes surgical morbidity but can come at the cost of operator ergonomics and technical surgical success. Here, the authors present a case series to report the first use of a novel 15-mm tubular retraction system with integrated lighting and visualization capabilities for MIS access to intracranial lesions.

OBJECTIVE:
To demonstrate feasibility and effectiveness of the 15-mm Aurora Surgiscope (Integra Lifesciences) for intracranial MIS approaches.

METHODS:
The 15-mm Aurora Surgiscope facilitated MIS approach to gain access to intraparenchymal pathologies. The device consists of a tubular access system with integrated light source and a reusable control unit that modifies video parameters. The port was inserted along a preplanned trajectory through a mini-craniotomy. Bimanual access allowed the surgeon to comfortably dissect/resect lesional tissue using high-quality video.

RESULTS:
Four patients are presented. In cases 1 and 2, the authors evacuated acute intracerebral hemorrhages. Both had <15 cc hemorrhage with improved or stable neurological examination. In case 3, the authors performed gross total resection of a cerebellar pilocytic astrocytoma. In case 4, the authors resected a mesial posterior temporal cavernoma. No perioperative/technical complications were noted.

CONCLUSION:
The Aurora Surgiscope system is a novel integrated tubular retraction, lighting, and visualization system that allows access to a wide variety of pathologies using a MIS approach. The Surgiscope allows the surgeon to use bimanual dexterity through a small access port while limiting the need for additional equipment such as microscope, exoscope, or endoscope.
Clonal behaviour of myogenic precursor cells throughout the vertebrate lifespan
Authors: Hughes Simon M. , Escaleira Roberta C. , Wanders Kees , Koth Jana , Wilkinson David G. , Xu Qiling 
Published: August 2022

ABSTRACT
To address questions of stem cell diversity during skeletal myogenesis, a Brainbow-like genetic cell lineage tracing method, dubbed Musclebow2, was derived by enhancer trapping in zebrafish. It is shown that, after initial formation of the primary myotome, at least 15 muscle precursor cells (mpcs) seed each somite, where they proliferate but contribute little to muscle growth prior to hatching. Thereafter, dermomyotome-derived mpc clones rapidly expand while some progeny undergo terminal differentiation, leading to stochastic clonal drift within the mpc pool. No evidence of cell-lineage-based clonal fate diversity was obtained. Neither fibre nor mpc death was observed in uninjured animals. Individual marked muscle fibres persist across much of the lifespan indicating low rates of nuclear turnover. In adulthood, early-marked mpc clones label stable blocks of tissue comprising a significant fraction of either epaxial or hypaxial somite. Fusion of cells from separate early-marked clones occurs in regions of clone overlap. Wounds are regenerated from several local mpcs; no evidence for specialised stem mpcs was obtained. In conclusion, our data indicate that most mpcs in muscle tissue contribute to local growth and repair and suggest that cellular turnover is low in the absence of trauma.
Mechanical role of the submembrane spectrin scaffold in red blood cells and neurons
Authors: Leterrier Christophe , Pullarkat Pramod A. 
Published: August 2022

ABSTRACT
Spectrins are large, evolutionarily well-conserved proteins that form highly organized scaffolds on the inner surface of eukaryotic cells. Their organization in different cell types or cellular compartments helps cells withstand mechanical challenges with unique strategies depending on the cell type. This Review discusses our understanding of the mechanical properties of spectrins, their very distinct organization in red blood cells and neurons as two examples, and the contribution of the scaffolds they form to the mechanical properties of these cells.
Hobotnica: exploring molecular signature quality
Authors: Stupnikov Alexey , Sizykh Alexey , Budkina Anna , Favorov Alexander , Afsari Bahman , Wheelan Sarah , Marchionni Luigi , Medvedeva Yulia 
Published: August 2022

A Molecular Features Set (MFS), is a result of a vast diversity of bioinformatics pipelines. The lack of a “gold standard” for most experimental data modalities makes it difficult to provide valid estimation for a particular MFS's quality. Yet, this goal can partially be achieved by analyzing inner-sample Distance Matrices (DM) and their power to distinguish between phenotypes.The quality of a DM can be assessed by summarizing its power to quantify the differences of inner-phenotype and outer-phenotype distances. This estimation of the DM quality can be construed as a measure of the MFS's quality. Here we propose Hobotnica, an approach to estimate MFSs quality by their ability to stratify data, and assign them significance scores, that allow for collating various signatures and comparing their quality for contrasting groups.
Tracking human interactions with a commercially-available robot over multiple days
Authors: Hortensius Ruud , Chaudhury Bishakha , Hoffmann Martin , Cross Emily 
Published: August 2022

Background: As research examining human-robot interaction moves from the laboratory to the real world, studies seeking to examine how people interact with robots face the question of which robotic platform to employ to collect data in situ. To facilitate the study of a broad range of individuals, from children to clinical populations, across diverse environments, from homes to schools, a robust, reproducible, low-cost and easy-to-use robotic platform is needed. Methods: We describe how a commercially available off-the-shelf robot, Cozmo, can be used to study embodied human-robot interactions in a wide variety of settings, including the user’s home. We describe the steps required to use this affordable and flexible platform for longitudinal human-robot interaction studies. First, we outline the technical specifications and requirements of this platform and accessories. We then show how log files containing detailed data on the human-robot interaction can be collected and extracted. Finally, we detail the types of information that can be retrieved from these data. Results: We present findings from a validation that mapped the behavioural repertoire of the Cozmo robot and introduce an accompanying interactive emotion classification tool to use with this robot. This tool combined with the data extracted from the log files can provide the necessary details to understand the psychological consequences of long-term interactions. Conclusions: This low-cost robotic platform has the potential to provide the field with a variety of valuable new possibilities to study the social cognitive processes underlying human-robot interactions within and beyond the research laboratory, which are user-driven and unconstrained in both time and place.
High-precision whispering gallery microsensors with ergodic spectra empowered by machine learning
Authors: Duan Bing , Zou Hanying , Chen Jin-Hui , Ma Chun Hui , Zhao Xingyun , Zheng Xiaolong , Wang Chuan , Liu Liang , Yang Daquan 
Published: August 2022

Whispering gallery mode (WGM) microcavities provide increasing opportunities for precision measurement due to their ultrahigh sensitivity, compact size, and fast response. However, the conventional WGM sensors rely on monitoring the changes of a single mode, and the abundant sensing information in WGM transmission spectra has not been fully utilized. Here, empowered by machine learning (ML), we propose and demonstrate an ergodic spectra sensing method in an optofluidic microcavity for high-precision pressure measurement. The developed ML method realizes the analysis of the full features of optical spectra. The prediction accuracy of 99.97% is obtained with the average error as low as 0.32 kPa in the pressure range of 100 kPa via the training and testing stages. We further achieve the real-time readout of arbitrary unknown pressure within the range of measurement, and a prediction accuracy of 99.51% is obtained. Moreover, we demonstrate that the ergodic spectra sensing accuracy is∼11.5%higher than that of simply extracting resonating modes’ wavelength. With the high sensitivity and prediction accuracy, this work opens up a new avenue for integrated intelligent optical sensing.
The potential role of serum expression profile of long non coding RNAs, Cox2 and HOTAIR as novel diagnostic biomarkers in systemic lupus erythematosus
Authors: Mahmoud Rania H. , Fouad Nermeen A. , Hefzy Enas M. , Shaker Olfat G. , Ahmed Tarek I. , Hussein Hoda A. , Nasr Maha H. , Zaki Othman M. , Abdelghaffar Noha K. , Abdelaleem Omayma O. 
Published: August 2022

Background
The role of the long non-coding RNAs (lncRNAs) in the pathogenesis of systemic lupus erythematosus (SLE) is mostly unknown, despite increasing evidence that lncRNAs extensively participate in physiological and pathological conditions.

Aim
To detect the level of lncRNA-Cox2, HOTAIR, IL-6, and MMP-9 in the serum of SLE patients and to correlate these levels with disease activity and patients’ clinical and laboratory data to evaluate the value of these biomarkers for SLE diagnosis and assessment of disease activity.

Methods
Blood samples from 58 SLE patients, and 60 healthy controls (HCs) were used for detection of lncRNAs-Cox2 and HOTAIR expression levels by real-time polymerase chain reaction. Both IL-6 and MMP-9 serum levels were assayed by enzyme-linked immunosorbent assay. Lupus activity was assessed with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI).

Results
The serum expression levels of lncRNA-Cox2 and HOTAIR were significantly up-regulated in SLE patients vs HCs (fold change [median (IQR) was 1.29(0.81–1.71, P<0.0001) and 2.68(0.95–3.67), P = 0.038) for lncRNA-Cox2 and HOTAIR, respectively. Serum levels of both IL-6 and MMP-9 were significantly high in SLE patients compared with HCs (P≤0.001 for each). The up-regulated lncRNA-Cox2 was positively associated with the presence of neurological manifestations in SLE patients (P = 0.007). Furthermore, HOTAIR expression level had significantly positive correlation with IL-6 (r = 0.578, P<0.0001), MMP-9 level (r = 0.762, P<0.0001), nephritis grades (r = 0.296, P = 0.024) and proteinuria (r = 0.287, P = 0.035). LncRNA-Cox2 showed sensitivity and specificity 72.4%, and 100.0% respectively. HOTAIR sensitivity was 60.3%, and specificity was 100.0%. By multiple logistic regression analysis, lncRNA-Cox2 and HOTAIR were found as SLE independent predictors.

Conclusion
LncRNA-COX2 and HOTAIR can be used as new non-invasive biomarkers for the diagnosis of SLE.
A prospective follow-up study on how long newborns are fasting in Debre Markos Comprehensive Specialized Hospital, Ethiopia, 2020
Authors: Kassie Bekalu , Wube Tejitu , Jara Dube , Teshome Muluken , Shiferaw Aster , Getaneh Sefinew , Desta Melaku 
Published: August 2022

Background
At birth, continuous flow of nutrients to the fetus in utero interrupted due to cut of the route /umbilical cord/. Instead of the cord, breast-mouth connection will be the next route in the extra uterine life. Nevertheless, limited data in our locality show the duration for how long immediate newborns are fasting.

Objective
This study aimed to assess time to initiation of breastfeeding and its predictors among postnatal mothers within 12 hours of birth in Debre Markos Comprehensive Specialized Hospital, North West Ethiopia, 2020.

Methods
A Facility based prospective follow-up study was conducted among 475 participants who were selected using systematic random sampling techniques. To collect the data, techniques including interview, chart review and observation were used. Data was entered to Epi-data version 3.1 and analyzed by STATA 14 software. A cox proportional hazards regression model was fitted to identify predictors for survival time. Results of the final model were expressed in terms of adjusted hazard ratio (AHR) with 95% confidence interval, statistical significance was declared with P-value is less than 0.05.

Results
Newborns were fasting breast-milk for the median time of 2 hours. In this study, 25% of participants initiated breastfeeding within 1 hour, pre-lacteal while 75% initiated within 3 hours. Gave birth to multiple babies (AHR 0.37, 95% CI (0.19, 0.69)), operative delivery (AHR 0.77, 95% CI (0.62, 0.96)), got advice on timely initiation of breastfeeding immediately after delivery (AHR 0.79, 95% CI (0.63, 0.97)), pre-lacteal feeding initiation (AHR 10.41, 95% CI (2.82, 38.47)) and neonatal sickness (AHR 0.08, 95% CI (0.03–0.19)) were statistically significant predictors for time to initiation of breastfeeding.

Conclusion
Fifty percent of mothers initiated breastfeeding within 2 hours. Most of them didn’t initiate breastfeeding based on world health organization’s recommendation, within one hour after delivery. Multiple birth, operative delivery, getting advice on timely initiation of breastfeeding immediately after delivery, giving pre-lacteal feeding and neonatal sickness were found to be predictors of time to initiation of breastfeeding.
Improvement on dimensional stability and mold resistance of wood modified by tannin acid and tung oil
Authors: Wang Yujiao , Zhang Runhua , Yang Mengqi , Peng Yao , Cao Jinzhen 
Published: August 2022

Abstract
In this study, two plant derived compounds, namely tannin acid (TA) and tung oil (TO) were used to modify southern yellow pine wood (Pinus spp.) to enhance its durability. Wood samples were firstly impregnated with aqueous TA solutions at 5, 10 and 15%, respectively, and then impregnated with TO. Samples treated by TA or TO alone were also prepared. The dimensional stability, hydrophobicity, mold resistance, and thermal stability of both treated and untreated wood were evaluated. The results showed that the dimensional stability and hydrophobicity of wood treated with 10% TA and TO (T10+TO group) improved significantly. Compared with control group, the water absorption of T10+TO group decreased by 80.0% after 192 h immersion, and the antiswelling efficiency reached up to 90.7%, with the contact angle of 118° at 50 s. The mold resistance of wood after 5% TA and TO treatment presented an effectiveness of 87.5%. Meanwhile, T10+TO group presented better thermal stability. Overall, this study revealed that wood impregnated by TA and TO exhibited excellent dimensional stability and anti-mold properties, which could be applicable to indoor environment.
Underwater wireless optical communications links: perspectives, challenges and recent trends
Authors: Mohammed Aisha S. , Adnan Salah A. , Ali Mazin Ali A. , Al-Azzawi Waleed Khalid 
Published: August 2022

Abstract
Underwater wireless optical communication (UOWC) systems have lately garnered a significant amount of attention for both academic purposes and trial applications. Although the idea is not new, the fact that seawater has a smaller window of absorption for blue-green light has reawakened interest in it, and it has grown an essential attraction because of its high bandwidth, it can cover a wide variety of underwater activities as compared to radio frequency and acoustic technologies. To monitor pollution, maintain oil pipelines, monitor climate change, conduct offshore investigations, and conduct oceanography research, the wireless transmission of information underwater technology is of importance to the military, industrial, and scientific organizations all around the world. The use of wavelengths of visible light to transmit secure data across point-to-point connections in underwater optical wireless communication (UOWC) compares well with the usage of free-space optical (FSO) communications. However, UWOC systems also have a huge amount of absorption and scattering introduced by the aquatic channels. Different from standard terrestrial free-space optical communication, many unique system design strategies have been investigated in recent years to solve these technological issues. This article presents a vision as well as various obstacles in the domain of underwater optical wireless communication, a detailed overview, and comparison of underwater communications techniques (UOWC) links, basic modulation technique techniques, and c pursuits on UWOC.
“I want her to be able to think in English”: challenges to heritage language maintenance in a monolingual society
Authors: Lising Loy 
Published: August 2022

AbstractFilipino migrants are the fifth largest migrant community in Australia. Filipino migration to the country has been driven by socioeconomic and political factors in both the Philippines and Australia. Against this context, this paper investigates heritage language maintenance practices of Filipino migrant families by using a 2019 interview-based research study with five Filipino migrant families residing in Sydney. The five families were selected based on two criteria: the region in the Philippines where they came from and having a focal child in primary school. The first criterion captured participants from different Philippine linguistic background, while the second ensured a common denominator across the five families that impacts on heritage language practices. Employing Family Language Policy (FLP) as a lens for analysis, the study shows three key findings: (1) the families came to Australia with multilingual repertoires; (2) the parents’ language beliefs, mostly motivated by economic and social pressures attached to their ability to speak English well, dictated the family language practices in the home; and (3) their understanding of language learning plays a significant role in their FLP. This research is significant in terms of its contribution to advocacy and sociolinguistic research on heritage language maintenance among Filipino migrants (199).