bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of classical and novel integrated machine learning models to predict sediment discharge during free-flow flushing
Authors: Javadi Fahime , Qaderi Kourosh , Ahmadi Mohammad Mehdi , Rahimpour Majid , Madadi Mohamad Reza , Mahdavi-Meymand Amin 
Published: November 2022

AbstractIn this study, the capabilities of classical and novel integrated machine learning models were investigated to predict sediment discharge (Qs) in free-flow flushing. Developed models include Multivariate Linear Regression (MLR), Artificial Neural Network (ANN), Adaptive Neuro-Fuzzy Inference System (ANFIS), Group Method of Data Handling (GMDH), and four hybrid forms of GMDH and Support Vector Regression (SVR) in combination with Henry Gas Solubility Optimization (HGSO) and Equilibrium Optimizer (EO) algorithms. The number of 160 datasets that were applied to assess these models was extracted from the Janssen (PhD’s Thesis, Engineering, Civil and Environmental Engineering. University of California, 1999) experimental study. Input parameters to predict Qs included the water level in the reservoir (hw), bed level in the flushing channel (hb), outflow (Qout), inflow (Qin), and elapsed time of flushing (T). The performance of all models was evaluated by four statistical indices of root mean square error (RMSE), mean absolute error (MAE), correlation coefficient (R2), and Mean absolute relative error (MARE). Evaluation of results demonstrated that the HGSO and EO algorithms could enhance the accuracy of the GMDH model (up to 26% and 22% in terms of RMSE), respectively. According to statistical criteria, the SVR-EO and SVR-HGSO provided the highest accuracy in both training (R2 = 0.98) and validation phases (R2 = 0.96). Moreover, among the developed models, the GMDH-HGSO algorithm provided excellent fitness to the observed data (R2 = 0.96, RMSE = 22.37, MAE = 15.65, and MARE = 0.26). The results indicated the high efficiency of the HGSO and EO algorithms in improving the accuracy of the GMDH and SVR models. However, among the developed models, the GMDH-HGSO is the most accurate model and is recommended for sediment transport modelling.
Normative cognition and the effects of a probiotic food intervention in first grade children in Côte d’Ivoire
Authors: Brett Bonnie E. , Doumbia Habib O. Y. , Koko Bruno K. , Koffi Frédéric Kouadio , Assa Savorgnan E. , Zahé Kollet Y. A. S. , Kort Remco , Sybesma Wilbert , Reid Gregor , de Weerth Carolina 
Published: November 2022

AbstractThe cognitive skills critical for success have largely been studied in Western populations, despite the fact that children in low- and middle-income countries are at risk to not reach their full developmental potential. Moreover, scientists should leverage recent discovery to explore means of boosting cognition in at-risk populations. This semi-randomized controlled trial examined normative cognitive development and whether it could be enhanced by consumption of a probiotic food in a sample of 251 4- to 7-year-old children in urban schools in Côte d’Ivoire. Participants completed executive functioning measures at baseline (T1) and 5 months later (T2). After T1, children in one school received a probiotic (N = 74) or placebo (N = 79) fermented dairy food every day they were in school for one semester; children in the other school (N = 98) continued their diet as usual. Children improved on all tests across time (Cohen’s d = 0.08–0.30). The effects of probiotic ingestion were inconclusive and are interpreted with caution due to socio-political factors affecting daily administration. Given the general feasibility of the study, we hope that it will serve as an inspiration for future research into child development and sustainable (health-promoting) interventions for school children in developing nations.
Hindcasting injection-induced aseismic slip and microseismicity at the Cooper Basin Enhanced Geothermal Systems Project
Authors: Wang Taiyi A. , Dunham Eric M. 
Published: November 2022

AbstractThere is a growing recognition that subsurface fluid injection can produce not only earthquakes, but also aseismic slip on faults. A major challenge in understanding interactions between injection-related aseismic and seismic slip on faults is identifying aseismic slip on the field scale, given that most monitored fields are only equipped with seismic arrays. We present a modeling workflow for evaluating the possibility of aseismic slip, given observational constraints on the spatial-temporal distribution of microseismicity, injection rate, and wellhead pressure. Our numerical model simultaneously simulates discrete off-fault microseismic events and aseismic slip on a main fault during fluid injection. We apply the workflow to the 2012 Enhanced Geothermal System injection episode at Cooper Basin, Australia, which aimed to stimulate a water-saturated granitic reservoir containing a highly permeable ($$k = 10^{-13} - 10^{-12}$$k=10-13-10-12$$\hbox {m}{^2}$$m2) fault zone. We find that aseismic slip likely contributed to half of the total moment release. In addition, fault weakening from pore pressure changes, not elastic stress transfer from aseismic slip, induces the majority of observed microseismic events, given the inferred stress state. We derive a theoretical model to better estimate the time-dependent spatial extent of seismicity triggered by increases in pore pressure. To our knowledge, this is the first time injection-induced aseismic slip in a granitic reservoir has been inferred, suggesting that aseismic slip could be widespread across a range of lithologies.
Nationally representative results on SARS-CoV-2 seroprevalence and testing in Germany at the end of 2020
Authors: Neuhauser Hannelore , Rosario Angelika Schaffrath , Butschalowsky Hans , Haller Sebastian , Hoebel Jens , Michel Janine , Nitsche Andreas , Poethko-Müller Christina , Prütz Franziska , Schlaud Martin , Steinhauer Hans W. , Wilking Hendrik , Wieler Lothar H. , Schaade Lars , Liebig Stefan , Gößwald Antje , Grabka Markus M. , Zinn Sabine , Ziese Thomas 
Published: November 2022

AbstractPre-vaccine SARS-CoV-2 seroprevalence data from Germany are scarce outside hotspots, and socioeconomic disparities remained largely unexplored. The nationwide representative RKI-SOEP study (15,122 participants, 18–99 years, 54% women) investigated seroprevalence and testing in a supplementary wave of the Socio-Economic-Panel conducted predominantly in October–November 2020. Self-collected oral-nasal swabs were PCR-positive in 0.4% and Euroimmun anti-SARS-CoV-2-S1-IgG ELISA from dry-capillary-blood antibody-positive in 1.3% (95% CI 0.9–1.7%, population-weighted, corrected for sensitivity = 0.811, specificity = 0.997). Seroprevalence was 1.7% (95% CI 1.2–2.3%) when additionally correcting for antibody decay. Overall infection prevalence including self-reports was 2.1%. We estimate 45% (95% CI 21–60%) undetected cases and lower detection in socioeconomically deprived districts. Prior SARS-CoV-2 testing was reported by 18% from the lower educational group vs. 25% and 26% from the medium and high educational group (p < 0.001, global test over three categories). Symptom-triggered test frequency was similar across educational groups. Routine testing was more common in low-educated adults, whereas travel-related testing and testing after contact with infected persons was more common in highly educated groups. This countrywide very low pre-vaccine seroprevalence in Germany at the end of 2020 can serve to evaluate the containment strategy. Our findings on social disparities indicate improvement potential in pandemic planning for people in socially disadvantaged circumstances.
Plant-produced recombinant cytokines IL-37b and IL-38 modulate inflammatory response from stimulated human PBMCs
Authors: Kolotilin Igor 
Published: November 2022

AbstractAffordable therapeutics are vitally needed for humans worldwide. Plant-based production of recombinant proteins can potentially enhance, back-up, or even substitute for the manufacturing capacity of the conventional, fermenter-based technologies. We plastome-engineered a tobacco cultivar to express high levels of two “plantakines” — recombinant human cytokines, interleukins IL-37b and IL-38, and confirmed their native conformation and folding. Assessment of their biological functionality was performed ex vivo by analyzing the effects exerted by the plantakines on levels of 11 cytokines secreted from human peripheral blood mononuclear cells (PBMCs) challenged with an inflammatory agent. Application of the plant-produced IL-37b and IL-38 in PBMCs stimulated with Lipopolysaccharide or Phytohaemagglutinin resulted in significant, and in particular cases—dose-dependent modulation of pro-inflammatory cytokines secretion, showing attenuation in two-thirds of significant level modulations observed. Plantakine treatments that increased inflammatory responses were associated with the higher dosage. Our results demonstrate feasibility of manufacturing functional recombinant human proteins using scalable, cost-effective and eco-friendly plant-based bioreactors.
Long non-coding RNAs as novel prognostic biomarkers for breast cancer in Egyptian women
Authors: El-Helkan Basma , Emam Manal , Mohanad Marwa , Fathy Shadia , Zekri Abdel Rahman , Ahmed Ola S. 
Published: November 2022

AbstractBreast cancer (BC), the most common type of malignant tumor, is the leading cause of death, having the highest incidence rate among women. The lack of early diagnostic tools is one of the clinical obstacles for BC treatment. The current study was designed to evaluate a panel of long non-coding RNAs (lncRNAs) BC040587, HOTAIR, MALAT1, CCAT1, CCAT2, PVT1, UCA1, SPRY4-IT1, PANDAR, and AK058003—and two mRNAs (SNCG, BDNF) as novel prognostic biomarkers for BC. This study was ethically approved by the Institutional Review Board of the National Cancer Institute, Cairo University. Our study included 75 women recently diagnosed with BC and 25 healthy women as normal controls. Patients were divided into three groups: 24 with benign breast diseases, 28 with metastatic breast cancer (MBC, stage IV), and 23 with non-metastatic breast cancer (NMBC, stage III). LncRNA and mRNA expression levels were measured in patient plasma using quantitative real-time PCR. We found that 10 lncRNAs (BCO40587, HOTAIR, PVT1, CCAT2, PANDAR, CCAT1, UCA1, SPRY4-IT1, AK058003, and MALAT1) and both mRNAs demonstrated at least a 2-fold change in expression with a more than 95% probability of significance. BCO40587 and SNCG were significantly up-regulated in MBC and NMBC patients (3.2- and 4-fold, respectively) compared with normal controls. The expression of UCA1 was repressed by 1.78-fold in MBC and NMBC patients compared with those with benign diseases. SPRY4-IT1 was down-regulated by 1.45-fold in MBC patients compared with NMBC and benign disease patients. Up-regulation of lncRNAs plays an important role in BC development. SNCG and BCO40587 may be potential prognostic markers for BC.The organization number is IORG0003381 (IRB No: IRB00004025).
An optical and electrochemical sensor based on l-arginine functionalized reduced graphene oxide
Authors: Ghanbari Sanaz , Ahour Fatemeh , Keshipour Sajjad 
Published: November 2022

AbstractThe electrochemical and photochemical properties of graphene derivatives could be significantly improved by modifications in the chemical structure. Herein, reduced graphene oxide (RGO) was functionalized with l-arginine (l-Arg) by an amidation reaction between the support and amino acid. Deposition of a powerful ligand, l-Arg, on the optically active support generated an effective optical chemosensor for the determination of Cd(II), Co(II), Pb(II), and Cu(II). In addition, l-Arg-RGO was used as an electrode modifier to fabricate l-Arg-RGO modified glassy-carbon electrode (l-Arg-RGO/GCE) to be employed in the selective detection of Pb(II) ions by differential pulse anodic stripping voltammetry (DP-ASV). l-Arg-RGO/GCE afforded better results than the bare GCE, RGO/GCE, and l-Arg functionalized graphene quantum dot modified GCE. The nanostructure of RGO, modification by l-Arg, and homogeneous immobilization of resultant nanoparticles at the electrode surface are the reasons for outstanding results. The proposed electrochemical sensor has a wide linear range with a limit of detection equal to 0.06 nM, leading to the easy detection of Pb(II) in the presence of other cations. This research highlighted that RGO as a promising support of optical, and electrochemical sensors could be used in the selective, and sensitive determination of transition metals depends on the nature of the modifier. Moreover, l-Arg as an abundant amino acid deserves to perch on the support for optical, and electrochemical determination of transition metals.
Device modeling of two-steps oxygen anneal-based submicron InGaZnO back-end-of-line field-effect transistor enabling short-channel effects suppression
Authors: Kim Donguk , Kim Je-Hyuk , Choi Woo Sik , Yang Tae Jun , Jang Jun Tae , Belmonte Attilio , Rassoul Nouredine , Subhechha Subhali , Delhougne Romain , Kar Gouri Sankar , Lee Wonsok , Cho Min Hee , Ha Daewon , Kim Dae Hwan 
Published: November 2022

AbstractAmorphous oxide semiconductor (AOS) field-effect transistors (FETs) have been integrated with complementary metal-oxide-semiconductor (CMOS) circuitry in the back end of line (BEOL) CMOS process; they are promising devices creating new and various functionalities. Therefore, it is urgent to understand the physics determining their scalability and establish a physics-based model for a robust device design of AOS BEOL FETs. However, the advantage emphasized to date has been mainly an ultralow leakage current of these devices. A device modeling that comprehensively optimizes the threshold voltage (VT), the short-channel effect (SCE), the subthreshold swing (SS), and the field-effect mobility (µFE) of short-channel AOS FETs has been rarely reported. In this study, the device modeling of two-steps oxygen anneal-based submicron indium-gallium-zinc-oxide (IGZO) BEOL FET enabling short-channel effects suppression is proposed and experimentally demonstrated. Both the process parameters determining the SCE and the device physics related to the SCE are elucidated through our modeling and a technology computer-aided design (TCAD) simulation. In addition, the procedure of extracting the model parameters is concretely supplied. Noticeably, the proposed device model and simulation framework reproduce all of the measured current–voltage (I–V),VTroll-off, and drain-induced barrier lowering (DIBL) characteristics according to the changes in the oxygen (O) partial pressure during the deposition of IGZO film, device structure, and channel length. Moreover, the results of an analysis based on the proposed model and the extracted parameters indicate that the SCE of submicron AOS FETs is effectively suppressed when the locally high oxygen-concentration region is used. Applying the two-step oxygen annealing to the double-gate (DG) FET can form this region, the beneficial effect of which is also proven through experimental results; the immunity to SCE is improved as the O-content controlled according to the partial O pressure during oxygen annealing increases. Furthermore, it is found that the essential factors in the device optimization are the subgap density of states (DOS), the oxygen content-dependent diffusion length of either the oxygen vacancy (VO) or O, and the separation between the top-gate edge and the source-drain contact hole. Our modeling and simulation results make it feasible to comprehensively optimize the device characteristic parameters, such asVT, SCE, SS, and µFE, of the submicron AOS BEOL FETs by independently controlling the lateral profile of the concentrations ofVOand O in two-step oxygen anneal process.
Skate, overtravel, and contact force of tilted triangular cantilevers for microcantilever-based MEMS probe technologies
Authors: Arscott Steve 
Published: November 2022

AbstractMicrofabricated chip-edge microcantilevers are commonly used as surface probes, e.g. in near-field microscopy. Such probes normally function in the low-deflection regime, where their behaviour is very well understood and documented. In contrast, when microcantilevers are used for applications such as electrical testing probes, their deflection can be somewhat higher, taking them into the less well understood high-deflection regime of microelectromechanical systems (MEMS). Here, a scalable model for the relationship between the skate, overtravel, and resulting tip contact force in tilted triangular cantilevers—which are bending with high deflection and in contact with a flat surface—is presented. The model is tested experimentally using macroscopic triangular cantilevers—the experimental results agree well with the proposed model. The findings enable a practical solution for zero-skate in tapered MEMS probes to be suggested. It is hoped that the findings may be of use for probe engineers involved with on-wafer testing and designers of emerging MEMS micro cantilever-based probes.
The impact of the COVID-19 pandemic-related quarantine on female sexual behavior: a cross-sectional study in China
Authors: Li Guangyong , Yu Puguang , Zhang Fen , Xu Yanlong , Zhou Gaiyan , Zhan Xuekang , Gao Yu , Du Xiaoli , Liu Hetao , He Rui 
Published: November 2022

AbstractTo investigate the impact and factors of home quarantine life on women’s sexual lives and behaviors in different areas of China and analyze the prevalence of female sexual dysfunction (FSD) during the COVID-19 pandemic. We surveyed adult women who had a regular sexual life (including regular masturbation) and had been isolated at home for at least one month during the COVID-19 outbreak using online questionnaires. This survey recovered 678 complete questionnaires after screening. According to the findings, the overall score of the Female Sexual Function Inventory (FSFI) during the pandemic was 21.98 ± 6.38, the frequency of FSD was 61.9%, and the frequencies of FSD in Shanghai, Nanjing, and Ningxia were 60.6%, 75.2%, and 52.2%, respectively. The frequency of FSFI scores and other specific items (Desire, Arousal, Lubrication, Orgasm, Satisfaction, and Pain) varied significantly across the three regions (P < 0.05). The overall frequency of FSD in the masturbation population was 34.4%, which was lower than the frequency of FSD in women having paired sexual intercourse (60.1%) (p < 0.05). Further analysis revealed that the occurrence of FSD during the pandemic was related to different age stages, menopause, mode of delivery, level of anxiety and depression, and sexual lifestyles. The COVID-19 pandemic has had a great impact on people’s spiritual and sexual lives, which are caused by multiple different variables related to both the individual and the environment. We should emphasize the importance of sexual health in epidemics, and having a harmonious and stable sex life will help us survive the boring life of isolation.
Characterization of antibiotic-resistance traits in Akkermansia muciniphila strains of human origin
Authors: Filardi Rossella , Gargari Giorgio , Mora Diego , Arioli Stefania 
Published: November 2022

AbstractAkkermansia muciniphila, a commensal bacterium commonly found in healthy gut microbiota, is widely considered a next-generation beneficial bacterium candidate to improve metabolic and inflammatory disorders. Recently the EFSA’s Panel on Nutrition, Novel food, and Food Allergens has declared that pasteurized A. muciniphila DSM 22959T (also MucT, ATCC BAA-835) can be considered safe as a novel food, opening the door to its commercialization as a food supplement. Despite its recognized health benefits, there is still little information regarding the antimicrobial susceptibility of this species and reference cut-off values to distinguish strains with intrinsic or acquired resistance from susceptible strains. In this study, we combined a genomic approach with the evaluation of the antibiotic susceptibility in five human A. muciniphila isolates. Genomic mining for antimicrobial resistance genes and MICs determinations revealed that only one strain harboring tetW gene showed resistance to tetracycline, whereas all A. muciniphila strains showed low sensitivity to ciprofloxacin and aminoglycosides with no genotypic correlation. Although all strains harbor the gene adeF, encoding for a subunit of the resistance-nodulation-cell division efflux pump system, potentially involved in ciprofloxacin resistance, the susceptibility towards ciprofloxacin determined in presence of efflux pump inhibitors was not affected. Overall, our outcomes revealed the importance to extend the antibiotic susceptibility test to a larger number of new isolates of A. muciniphila to better assess the safety aspects of this species.
Results from Canton Grisons of Switzerland suggest repetitive testing reduces SARS-CoV-2 incidence (February–March 2021)
Authors: Gorji Hossein , Lunati Ivan , Rudolf Fabian , Vidondo Beatriz , Hardt Wolf-Dietrich , Jenny Patrick , Engel Doortje , Schneider Jörg , Jamnicki Marina , Leuthold Rudolf , Risch Lorenz , Risch Martin , Bühler Martin , Sommer Adrian , Caduff Alexa 
Published: November 2022

AbstractIn February 2021, in response to emergence of more transmissible SARS-CoV-2 virus variants, the Canton Grisons launched a unique RNA mass testing program targeting the labour force in local businesses. Employees were offered weekly tests free of charge and on a voluntary basis. If tested positive, they were required to self-isolate for ten days and their contacts were subjected to daily testing at work. Thereby, the quarantine of contact persons could be waved.Here, we evaluate the effects of the testing program on the tested cohorts. We examined 121,364 test results from 27,514 participants during February–March 2021. By distinguishing different cohorts of employees, we observe a noticeable decrease in the test positivity rate and a statistically significant reduction in the associated incidence rate over the considered period. The reduction in the latter ranges between 18 and 50%. The variability is partly explained by different exposures to exogenous infection sources (e.g., contacts with visiting tourists or cross-border commuters). Our analysis provides the first empirical evidence that applying repetitive mass testing to a real population over an extended period of time can prevent spread of COVID-19 pandemic. However, to overcome logistic, uptake, and adherence challenges it is important that the program is carefully designed and that disease incursion from the population outside of the program is considered and controlled.