bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selection of wheat (Triticum aestivum) lines for the high altitude of Indonesia based on single- and multi-character adaptation
Authors: WAHYU YUDIWANTI , NURAENI ELIS , TRIKOESOEMANINGTYAS TRIKOESOEMANINGTYAS 
Published: February 2022

Abstract. Nuraeni E, Wahyu Y, Trikoesoemaningtyas. 2021. Selection of wheat (Triticum aestivum) lines for the high altitude of Indonesia based on single- and multi-character adaptation. Biodiversitas 22: 5530-5535. The high demand for wheat in Indonesia encourages the assembly of wheat varieties adaptive to the tropical environment. The increase in wheat diversity has been carried out through the crossing process, and it is necessary to evaluate the adaptability of the genotypes resulting from the cross. This study aims to obtain information on the adaptation classes of the F5 population and the differential of agronomic character selection in single and multi-character selection. The study was conducted at the BB Biogen Experimental Garden, Ciwalen (925 masl), in August-December 2020. The F5 of HP1744/Selayar population was used as genetic material with two comparison varieties, namely Guri 1 and Guri 3. The adaptation class for a single character was determined based on seed weight per plant, while for multi-character based on the characters with a wedge between the high category heritability value and the correlation coefficient ?0.5. The result showed that the number of florets, seed weight per plant, number of tillers, number of productive tillers, and weight of seeds in the main panicle were selected as a reference for multi-character selection. The t-test showed that the adaptive and highly adaptive classes genotypes had higher yields than the comparison varieties. The selection differential shows an increase in the mean value for all reference characters. The adaptation class based on a single character resulted in a higher average value of seed weight in all classes compared to selection based on multi-character.
Patient preferences for long-term follow-up after hip replacement
Authors: Smith LK , Turner E , Dures E 
Published: February 2022

Background Reports of surgical training and experiences vary across the 16 UK foundation schools. Little is known about whether foundation school choice is associated with later performance in surgical training. We investigated choice of school in relation to performance in the MRCS Part A. Materials and methods A retrospective cohort study of foundation programme trainees who attempted MRCS Part A between 2017 and 2020 (n = 553). Chi-square tests examined associations between foundation programme school and first–attempt MRCS Part A performance. Multinomial regression models identified the likelihood of MRCS part A success depending on foundation school. Results A statistically significant association was found between MRCS Part A first attempt pass rates and foundation school (P < 0.001). Mean Part A pass rates ranged from 23.8% to 81.8% between schools. Two foundation schools – Thames Valley and North, Central and East London – were found to be independent predictors of success at MRCS Part A at first attempt after adjusting for age, gender and ethnicity (P < 0.05). There was no significant correlation between MRCS Part A performance and subjective reports of training quality (the National Training Survey training satisfaction scores; P =0.256). Conclusions MRCS success is associated with foundation school but not subjective reports of training quality. Given that more competitive foundation schools attract the highest-achieving applicants, Occam's razor suggests this pattern is most likely due to individual differences such as innate academic ability rather than foundation school training experiences.
Impact of the COVID-19 pandemic on dental students: a cross-sectional study across UK universities
Authors: Al-Attar Sumaya , Jiagbogu Miriam , O’Malley Lucy , Lin Yin-Ling 
Published: February 2022

INTRODUCTION The COVID-19 pandemic led to closure of the 16 UK dental schools and a shift to remote learning. The aim of this study was to explore the impact on the teaching and learning experiences of undergraduate dental students, including their clinical confidence and mental health. METHODS An online survey was distributed to students enrolled at UK dental schools during the time of closure. Paired samples t-tests were employed to analyse the results. RESULTS A total of 312 students responded to the survey. Eighty-five per cent felt that the university closure had a negative impact on their overall learning. Ninety-seven per cent thought their clinical skills would be affected; perceived confidence in treating patients decreased by 27%. The mental health of all respondents was negatively affected although their stress about their studies was not affected. Positive aspects of closure included remote learning and online examinations. CONCLUSIONS The pandemic had both negative and positive impacts on dental students’ education. Universities should adapt their response to future crises and incorporate the positive impacts in future curriculums. Further studies could explore the long-term impact on students’ mental health and clinical skills.
DMF (different, missed, forgotten): oral health inequalities experienced by people with severe mental illness
Authors: Browne Maeve , Beenstock Jane 
Published: February 2022

In England, there are over half a million people living with severe mental illness (SMI) such as schizophrenia and bipolar disorder. These people die on average up to 20 years earlier than the general population and 2 in 3 deaths are from physical illnesses that can be prevented. Recent government publications such as the NHS Long Term Plan and NHS England's mental health implementation plan have highlighted the need to address the physical health needs of people with SMI in order to reduce the serious inequality of health outcomes experienced. Disappointingly, however, neither document mentions the poor oral health experienced by this cohort of the population, nor do they recognise the link between poor oral health and poor general health. This article examines the available literature and results from a recent survey that explored the oral health behaviours of service users at a secure mental health facility to raise awareness of the oral health needs of this population. Oral health is an integral aspect of general health and can positively influence wellbeing. A healthy mouth ensures individuals can eat, speak and interact socially, free from pain and embarrassment. Poor oral health can therefore not only have a profound impact on a person's quality of life (QoL) but it can also have wider implications for systemic disease.
Delivering a remote induction programme for dental core trainees: an innovative learner-centric approach during the COVID-19 pandemic
Authors: Payne Karl , Tahim Arpan , Goodson Alexander , O'Connor Rory , Ahmed Nabeela , Evans Martin , Gruber Elizabeth , Gallagher James , Sharp Ian , Dickenson Andrew 
Published: February 2022

The absence of face-to-face teaching during the COVID-19 pandemic has created particular challenges for clinical postgraduate educators. Induction for dental core trainees (DCTs) entering secondary care posts for the first time is of prime importance, with the aim of delivering a comprehensive course covering core topics, fundamental to patient safety. This paper describes the adaptation and delivery of a remote DCT induction programme for the Midlands and East of England area. Using a 'flipped classroom' approach, prior induction content was adapted to provide online pre-recorded lectures and learning resources to prepare for web-based video conferencing case-based discussions. In order to assess the quality of teaching and success of the course, participants completed three questionnaires: identical assessments before and after the course to evaluate a change in knowledge and confidence, and a course evaluation survey. In total, 126 DCTs attended the induction course, with response rates of 82%, 75% and 61% for the 3 questionnaires respectively. Comparing DCT knowledge and confidence in treating patients before and after the course, there was a statistically significant increase in 13 of 14 domains. Despite being a web-based course, 100% of participants described the case-based small group discussions as ‘interactive and enjoyable’, with overall positive feedback for the delivery of a remote induction course We demonstrate how a remote web-based induction course for DCTs is achievable and has potential advantages with regard to pooling of resources and faculty. Several key learning points are discussed, in addition to the potential for a standardised framework for national DCT induction.
High-performance dual-band radio-over-fiber link for future 5G radio access applications
Authors: Shi Fangjing , Fan Yangyu , Wang Xinyuan , Zhang Wu , Gao Yongsheng 
Published: February 2022

For the fronthaul between the baseband unit and the remote radio unit (RRU), radio over fiber (RoF) is promising to replace the Common Public Radio Interface in beyond fifth-generation and the sixth-generation wireless communication systems. The weight, size, and power consumption of the RRU can be greatly reduced, along with easy support for the millimeter-wave band. In this paper, a dual-band RoF link is proposed, where flexible switching between high-frequency (28 GHz) and low-frequency (3.5 GHz) RF channels is realized through polarization control. Single-sideband modulation is performed on 28 GHz signals to avoid periodic power fading during long-distance fiber transmission. By adjusting the DC bias, the third-order intermodulation distortion component in the 3.5 GHz signal is suppressed, and the spur-free dynamic range (SFDR) is improved. Experimental results show a channel isolation of above 43 dB. The link gain of the 28 GHz signal channel is flat, and the SFDR of the 3.5 GHz signal channel can reach

118.6

d
B
⋅
H

z

4

/

5

. In the case of RF vector signal transmission, the adjacent channel power ratio of the 3.5 GHz signal channel is optimally up to 48 dB, and the error vector magnitude is 2.9%.
Toward higher-radix switches with co-packaged optics for improved network locality in data center and HPC networks [Invited]
Authors: Maniotis Pavlos , Schares Laurent , Kuchta Daniel M. , Karacali Bengi 
Published: February 2022

We study the network locality improvements that can be achieved by using co-packaged optics in data center and high-performance computing (HPC) networks. The increased escape bandwidth offered by co-packaged optics can enable switches with speeds of 51.2 Tb/s and beyond. From a network architecture perspective, the key advantages of introducing co-packaged optics at the switch points include the implementation of large-scale topologies of

>

12,000

end points with

4
×

higher bisection bandwidth and the reduction of the required number of switches by

>

40

%

compared with state-of-the-art approaches. From a network operation perspective, improved network locality and faster operation can be achieved since the higher-radix switches can mitigate the impact of network contention. Placing applications under fewer leaf switches reduces the number of packets that cross the spine switches in a leaf-spine topology. The proposed scheme is evaluated via discrete-event simulations: we initially evaluate the network locality properties of the system by using virtual-machine traces from a production data center, and we subsequently quantify the performance improvements by simulating an all-to-all pattern for a variety of message sizes over a number of nodes. The results suggest that co-packaged optics form a promising solution for keeping up with bandwidth scaling in future networks. The virtual-machine analysis shows that large-scale applications can be placed under up to 50% fewer first-level switches, while the network analysis shows speedups of up to 7.1, which translates to execution time reductions of up to 26% and 42.7% for applications with communication ratios of 0.3 and 0.5, respectively.
Cell-free tumor DNA, CA125 and HE4 for the objective assessment of tumor burden in patients with advanced high-grade serous ovarian cancer
Authors: Heitz Florian , Lakis Sotirios , Harter Philipp , Heikaus Sebastian , Sehouli Jalid , Talwar Jatin , Menon Roopika , Ataseven Beyhan , Bertrand Miriam , Schneider Stephanie , Mariotti Erika , Bommert Mareike , Müller Judith N. , Prader Sonia , Leenders Frauke , Hengsbach Alexandra , Gloeckner Christian , Braicu Elena Ioana , Heukamp Lukas C. , du Bois Andreas , Heuckmann Johannes M. 
Published: February 2022

Background
The present prospective study aimed at determining the impact of cell-free tumor DNA (ct-DNA), CA125 and HE4 from blood and ascites for quantification of tumor burden in patients with advanced high-grade serous epithelial ovarian cancer (EOC).

Methods
Genomic DNA was extracted from tumor FFPE and ct-DNA from plasma before surgery and on subsequent post-surgical days. Extracted DNA was subjected to hybrid-capture based next generation sequencing. Blood and ascites were sampled before surgery and on subsequent post-surgical days. 20 patients (10 undergoing complete resection (TR0), 10 undergoing incomplete resection (TR>0)) were included.

Results
The minor allele frequency (MAF) of TP53 mutations in ct-DNA of all patients with TR0 decreased significantly, compared to only one patient with TR>0. It was not possible to distinguish between patients with TR0 and patients with TR>0, using CA125 and HE4 from blood and ascites.

Conclusions
Based upon the present findings, ct-DNA assessment in patients with high-grade serous EOC might help to better determine disease burden compared to standard tumor markers. Further studies should prospectively evaluate whether this enhancement of accuracy can help to optimize management of patients with EOC.
A prospective registry-based cohort study of the diagnosis and management of acute leukaemia in pregnancy: Study protocol
Authors: Northgraves Matthew , Allsup David , Cohen Judith , Huang Chao , Turgoose John , Ali Sahra 
Published: February 2022

Background
Acute leukaemias (AL) are aggressive but potentially curable blood cancers that can potentially affect women of childbearing age. When a pregnancy is complicated by a diagnosis of AL, clinicians face a complex dilemma: to balance risking the mother’s survival through delayed AL treatment, against the potential harm to the foetus through exposure to anti-cancer drugs. Up until now, all guidance and advice regarding the management of AL in pregnancy, have been based on expert opinion and small case studies. There is a pressing need for more studies in the subject to address this evidence gap.

Methods and analysis
This study is a registry-based observational cohort study which aims to monitor and record the treatment outcomes of patients diagnosed with AL during pregnancy. Additionally, the study aims to assess pregnancy outcomes in patients who become pregnant following successful treatment. Prospective and historical cases from August 2009 onwards will be identified from AL treating haematology units within the UK. Details of diagnosis, AL treatment delivered, antenatal and postnatal outcomes for mother and neonate will be collected. This study will establish a new research database for Leukaemia in Pregnancy.

Trial registration
The study was registered on Clinicaltrials.gov (NCT04182074) on the 2nd December 2019.
Implementing and optimizing a communication curriculum in medical teaching: Stakeholders’ perspectives
Authors: Brünahl Christian Andreas , Hinding Barbara , Eilers Leonie , Höck Jennifer , Hollinderbäumer Anke , Buggenhagen Holger , Reschke Kirsten , Schultz Jobst-Hendrik , Jünger Jana 
Published: February 2022

Objective
The relevance of communication in medical education is continuously increasing. At the Medical Faculty of Hamburg, the communication curriculum was further developed and optimized during this project. This article aims to describe the stakeholders’ perceived challenges and supporting factors in the implementation and optimization processes.

Methods
The initial communication curriculum and its development after a one-year optimization process were assessed with a curricular mapping. A SWOT analysis and group discussions were carried out to provide information on the need for optimization and on challenges the different stakeholders faced.

Results
The curricular mapping showed that the communication curriculum is comprehensive, coherent, integrated and longitudinal. In both the implementation and the project-related optimization processes, support from the dean, cooperation among all stakeholders and structural prerequisites were deemed the most critical factors for successfully integrating communication content into the curriculum.

Conclusion
The initiative and support of all stakeholders, including the dean, teachers and students, were crucial for the project’s success.

Practice implications
Although the implementation of a communication curriculum is recommended for all medical faculties, their actual implementation processes may differ. In a “top-down” and “bottom-up” approach, all stakeholders should be continuously involved in the process to ensure successful integration.
Psychosocial and environmental determinants of physical activity in a Brazilian public university employees - ELDAF: A prospective cohort study protocol
Authors: Oliveira Aldair J. , Lopes Claudia S. , Maranhão Neto Geraldo de Albuquerque , de Sousa Gustavo Mota , Paravidino Vitor , Rostila Mikael , Felippe Felix Mediano Mauro , Griep Rosane Harter , do Vale Wesley Souza , Frota da Rocha Morgado Fabiane 
Published: February 2022

Background
Increased physical activity levels and their determinations are essential issues worldwide. The Longitudinal Study of Physical Activity Determinants (ELDAF) aims to understand the roles of psychosocial and environmental factors in workers’ physical activity levels.

Methods
A prospective cohort study of non-faculty civil servants from a public university (approximately 1,200 individuals) will start in 2022 (baseline). The primary measurements will be accelerometer- and questionnaire-based physical activity, social support, social network, socioeconomic status, bereavement, job stress, body image, common mental disorders, depression, and neighborhood satisfaction. Additional measurements will include necessary sociodemographic, physical morbidity, lifestyle and anthropometric information. Participants’ places of residence will be geocoded using complete addresses. All participants will furnish written, informed consent before the beginning of the study. Pilot studies were performed to identify and correct potential problems in the data collection instruments and procedures. ELDAF will be the first cohort study conducted in Latin America to investigate physical activity and its determinants.
Effect of osteoporosis-related reduction in the mechanical properties of bone on the acetabular fracture during a sideways fall: A parametric finite element approach
Authors: Khakpour Shahab , Esrafilian Amir , Tanska Petri , Mononen Mika E. , Korhonen Rami K. , Jämsä Timo 
Published: February 2022

Purpose
The incidence of acetabular fractures due to low-energy falls is increasing among the geriatric population. Studies have shown that several biomechanical factors such as body configuration, impact velocity, and trochanteric soft-tissue thickness contribute to the severity and type of acetabular fracture. The effect of reduction in apparent density and elastic modulus of bone as well as other bone mechanical properties due to osteoporosis on low-energy acetabular fractures has not been investigated.

Methods
The current comprehensive finite element study aimed to study the effect of reduction in bone mechanical properties (trabecular, cortical, and trabecular + cortical) on the risk and type of acetabular fracture. Also, the effect of reduction in the mechanical properties of bone on the load-transferring mechanism within the pelvic girdle was examined.

Results
We observed that while the reduction in the mechanical properties of trabecular bone considerably affects the severity and area of trabecular bone failure, reduction in mechanical properties of cortical bone moderately influences both cortical and trabecular bone failure. The results also indicated that by reducing bone mechanical properties, the type of acetabular fracture turns from elementary to associated, which requires a more extensive intervention and rehabilitation period. Finally, we observed that the cortical bone plays a substantial role in load transfer, and by increasing reduction in the mechanical properties of cortical bone, a greater share of load is transmitted toward the pubic symphysis.

Conclusion
This study increases our understanding of the effect of osteoporosis progression on the incidence of low-energy acetabular fractures. The osteoporosis-related reduction in the mechanical properties of cortical bone appears to affect both the cortical and trabecular bones. Also, during the extreme reduction in the mechanical properties of bone, the acetabular fracture type will be more complicated. Finally, during the final stages of osteoporosis (high reduction in mechanical properties of bone) a smaller share of impact load is transferred by impact-side hemipelvis to the sacrum, therefore, an osteoporotic pelvis might mitigate the risk of sacral fracture.
Value of C-11 methionine PET/CT in patients with intracranial germinoma
Authors: Park Yong-Jin , Lee Ji Won , Cho Hee Won , Choe Yearn Seong , Lee Kyung-Han , Choi Joon Young , Sung Ki Woong , Moon Seung Hwan 
Published: February 2022

Purpose
The purpose of this study was to investigate the value of C-11 methionine (MET) positron emission tomography (PET)/computed tomography (CT) in patients with intracranial germinoma (IG).

Material and methods
We conducted a retrospective analysis of 21 consecutive patients with pathologically confirmed IGs and eight patients with intracranial non-germinomas (INGs) located in a similar region. Clinical characteristics, imaging findings, and tumor markers such as α-fetoprotein (AFP) and β-human chorionic gonadotropin (HCG) were used as clinical variables. Maximum standardized uptake value (SUVmax), tumor-to-normal tissue (T/N) ratio, and visual scoring of tumor were used as MET PET parameters.

Results
All IGs were well visualized on MET PET with a three-grade visual scoring system. In addition, SUVmax of IGs was higher than that of INGs (P = 0.005). Pre-treatment (Pre-Tx) T/N ratio was significantly correlated with pre-Tx serum HCG (P = 0.031). Moreover, MET PET parameters showed significant associations with tumor location, sex, KRAS variant, and symptoms.

Conclusion
MET PET/CT could be a useful diagnostic tool in patients suspected of having IGs. In addition, the MET avidity of tumor is a potential surrogate biomarker of HCG, which has been used as a diagnostic marker for IGs. Tumor MET parameters also had significant differences according to tumor locations, sex, symptoms, and KRAS mutation. However, MET avidity of tumors had no significant prognostic value.