bluuebunny/crossref_metadata_2025_split huggingface dataset:
Question storming: The power of Questions—A method to increase options for action in uncertainty
Authors: Mennin Stewart , Eoyang Glenda H. 
Published: May 2022

AbstractRationaleQuestion Storming offers a method that enables one to hold the condition of uncertainty in reflection without the need for resolution. Global interdependencies and unprecedented access to information, social media and multiple forms of communications challenge our ability to see, understand and influence change effectively and efficiently. The tension and need to cope effectively with massive uncertainties cannot be resolved with current methods leading to a necessity for people to seek new ways to transform their understanding and explore new options for action. Problem‐solving and facilitation of the past are not flexible or rapid enough to meet the current demands of decision making and action taking in the face of massive uncertainties. As a result, people face ‘wicked unsolvable’ issues in their personal and professional lives.Aims and ObjectivesAn international group of scholar‐practitioners has adapted and tested an enquiry process. Question Storming—The Power of Questions is based on principles of complex adaptive systems, human systems dynamics, and self‐organization.MethodA three‐step method of inquiry and reflection opens new possibilities.Results and ConclusionsQuestion Storming has helped people see their wicked issues from new perspectives, understand them in useful ways and generate new options for action. This paper introduces Question Storming—the Power of Questions as a practical method for group inquiry in the presence of individual and group uncertainties/wicked issues. The Container, Difference, Exchange (CDE) model and Pattern Logic are presented to explain the paradigm‐shifting dynamics experienced by participants, both individuals and members of the group. It concludes with emerging questions for future consideration. Question Storming generates a divergent problem space that decreases constraint and increases degrees of freedom to allow practical exploration of new and often surprising options for action.
Minor traumatic injuries in the emergency department pre‐ and post‐implementation of an emergency care access point
Authors: van der Baaren Rens , Barten Dennis G. , van Osch Frits , van Barneveld Kevin W. Y. , Janzing Heinrich M. J. , Cals Jochen W. L. 
Published: May 2022

AbstractObjectiveIn the Netherlands, out‐of‐hours General Practice Cooperatives (GPCs) increasingly collaborate with Emergency Departments (EDs) to form an Emergency Care Access Point (ECAP). ECAPs aim to decrease the number of low‐urgent ED attendances, of which many compromise minor traumatic injuries. In this study, we evaluated the impact of ECAP implementation on the incidence of minor traumatic injuries in the ED.MethodsWe evaluated a total of 2772 ED patients who presented with a minor traumatic injury (categorized into traumatic wounds and isolated extremity injuries) 1 year before and 1 year after ECAP implementation. We compared patient characteristics, throughput, diagnosis, treatment and follow‐up before and after ECAP implementation.ResultsECAP implementation was associated with a reduction in ED volume for minor traumatic injuries: −12.4% for isolated extremity injuries (1249 vs. 1094) and −74.6% for traumatic wounds (342 vs. 87). Multivariable logistic regression analysis controlling for patient characteristics showed that ECAP implementation was associated with higher rates of substantial injuries in the ED (OR 1.20, 95% CI = 1.01–1.43), and more patients requiring outpatient follow‐up.ConclusionImplementation of an ECAP was associated with a reduction of ED utilization by patients with minor traumatic injuries, traumatic wounds in particular. This healthcare intervention may therefore help to reduce ED utilization for low‐urgent complaints.
The effect of different application modes of a 1‐step self‐etch adhesive on the clinical performance of Class I composite restorations: A randomized controlled clinical trial
Authors: Demirci Mustafa , Tuncer Safa , Tekçe Neslihan , Baydemir Canan 
Published: May 2022

AbstractObjectiveTo evaluate the clinical performance of a 1‐step self‐etch dentin adhesive that was applied according to the manufacturers' recommendations, doubling the adhesive application time and layer in Class I cavities with a composite resin.Materials and MethodsA total of 39 patients aged between 14 and 43 (mean age: 19.1) years were enrolled in the study. Each patient received three restorations. In these three restorations, a 1‐step self‐etch adhesive was applied according to the manufacturer's recommendations (control group), by doubling the adhesive application time, and with double layers. The restorations were evaluated according to modified USPHS criteria at baseline, and 1, 2, 3, and 4‐year recalls.ResultsAfter 4 years, the success rate was 100% for restorations with the adhesive applied according to the manufacturers' recommendations, 96.9% for restorations applied by doubling the adhesive application time, and 93.8% for restorations applied with double adhesive layers. There was no significant difference between the three application methods among all the evaluation periods regarding the evaluation criteria.ConclusionsThe 4‐year success rates of a 1‐step self‐etch dentin adhesive that was applied according to the manufacturers' recommendation, by doubling the adhesive application time, and with double layers were excellent.Clinical SignificanceIt is not recommended to double the adhesive application time nor apply a double layer of a 1‐step self‐etch adhesive because it does not improve the clinical performance of Class I composite restorations.
Treated together–changed together: The application of dyadic analyses to understand the reciprocal nature of alliances and couple satisfaction over time
Authors: Whittaker Kristoffer J. , Johnson Sverre Urnes , Solbakken Ole André , Tilden Terje 
Published: May 2022

AbstractIn a Norwegian study of 73 couples attending a residential couple therapy program lasting between 6 and 12 weeks, weekly self‐report data on therapy alliance and couple satisfaction were collected using routine outcome monitoring (ROM). The aim was to show how dyadic analyses could be applied to examine the predictive association between alliances and couple satisfaction. Results showed that improved alliance between dyad members and their couple therapist predicted their spouses' couple satisfaction. Furthermore, improved couple satisfaction predicted improvement in spouse's alliance. The clinical implication of these findings should heighten awareness to the importance of establishing and maintaining the alliance of male partners in couple therapy, something that predicts their spouses' couple satisfaction. These findings help nuance the already existing literature on the working alliance. Furthermore, we propose that dyadic analyses should be widely used in any psychotherapeutic research that aims to understand the reciprocal effects of dyads.
Perinatal and neonatal outcomes of women with very early preterm premature rupture of membranes treated via serial transabdominal amnioinfusion and expectant management: Experience of a tertiary referral center in Turkey
Authors: Melekoglu Rauf , Celik Ebru 
Published: May 2022

AbstractAimWe compared the outcomes of serial transabdominal amnioinfusion and expectant management on the perinatal and neonatal outcomes of pregnancies complicated with very early preterm premature rupture of membranes (PPROM).MethodsWe retrospectively reviewed the records of patients with very early PPROM admitted to the University of Inonu School of Medicine from 2014 to 2019. All such patients received comprehensive counseling on the possible prognoses; all were offered pregnancy termination, expectant management, and serial transabdominal infusion.ResultsSixty‐three women met the inclusion criteria; 36 were assigned to the expectant management group and 27 were assigned to the amnioinfusion group. The median delivery latency and the gestational age at delivery were significantly higher in the amnioinfusion than the expectant management group [35 (11–90), 14 (7–48), p < 0.001; 27.6 (22.1–34.0), 22.3 (19.0–26.5), p < 0.001, respectively]. Serial transabdominal amnioinfusion was associated with significantly less neonatal mortality than expectant management (29.6 vs 83.3%, p < 0.001). Multivariate binary logistic regression showed that the odds of neonatal mortality were 6.12 times higher among neonates in the expectant management group compared to that of the serial transabdominal amnioinfusion group after adjusting for potential confounders. Severe neonatal morbidities were significantly more common in the expectant management group than in the amnioinfusion group (p = 0.011).ConclusionThe present study has demonstrated a significant positive effect of serial transabdominal amnioinfusion procedure on latency period and neonatal morbidity and mortality in pregnant women complicated with very early PPROM.
Application of precision medicine in clinical routine in haematology—Challenges and opportunities
Authors: Wästerlid Tove , Cavelier Lucia , Haferlach Claudia , Konopleva Marina , Fröhling Stefan , Östling Päivi , Bullinger Lars , Fioretos Thoas , Smedby Karin E. 
Published: May 2022

AbstractPrecision medicine is revolutionising patient care in cancer. As more knowledge is gained about the impact of specific genetic lesions on diagnosis, prognosis and treatment response, diagnostic precision and the possibility for optimal individual treatment choice have improved. Identification of hallmark genetic aberrations such as the BCR::ABL1 gene fusion in chronic myeloid leukaemia (CML) led to the rapid development of efficient targeted therapy and molecular follow‐up, vastly improving survival for patients with CML during recent decades. The assessment of translocations, copy number changes and point mutations are crucial for the diagnosis and risk stratification of acute myeloid leukaemia and myelodysplastic syndromes. Still, the often heterogeneous and complex genetic landscape of haematological malignancies presents several challenges for the implementation of precision medicine to guide diagnosis, prognosis and treatment choice. This review provides an introduction and overview of the important molecular characteristics and methods currently applied in clinical practice to guide clinical decision making in haematological malignancies of myeloid and lymphoid origin. Further, experimental ways to guide the choice of targeted therapy for refractory patients are reviewed, such as functional precision medicine using drug profiling. An example of the use of pipeline studies where the treatment is chosen according to the molecular characteristics in rare solid malignancies is also provided. Finally, the future opportunities and remaining challenges of precision medicine in the real world are discussed.
Night‐to‐night associations between light exposure and sleep health
Authors: Mead Michael P. , Reid Kathryn J. , Knutson Kristen L. 
Published: May 2022

SummaryPrevious research has demonstrated that exposure to light preceding and during sleep is associated with poor sleep, but most research to date has utilized either experimental or cross‐sectional designs. The current study expands upon prior studies by using a microlongitudinal design that examines the night‐to‐night associations between light and sleep health in a diverse sample of adults (pre‐registered at osf.io/k5zgv). US adults aged 18–87 years from two parent studies (N = 124) wore an actiwatch for up to 10 nights. Light variables estimated from actigraphy include both average exposure and time above light threshold of 10 (TALT10) and 40 (TALT40) lux both during sleep and for the 1‐hr preceding sleep. Actigraphy‐based sleep variables included sleep offset, duration, percentage and fragmentation index. Higher average light exposure during sleep was associated with a later sleep‐offset time, lower sleep percentage and higher fragmentation index (all p < 0.01). More minutes of TALT10 during sleep was associated with later sleep timing, lower sleep percentage and higher fragmentation index (all p < 0.01), and greater TALT40 during sleep was associated with lower sleep percentage. Light exposure was not related to sleep duration. In summary, greater light exposure during sleep was related to poorer sleep continuity and later wake time. The lack of association between light and sleep duration may be the result of compensating for sleep disruption by delaying wake time. Multi‐level interventions to consistently reduce light levels during sleep should be considered.
Integrating experiments to predict interactive cue effects on spring phenology with warming
Authors: Wolkovich E. M. , Chamberlain C. J. , Buonaiuto D. M. , Ettinger A. K. , Morales‐Castilla I. 
Published: May 2022

SummaryClimate change has advanced plant phenology globally 4–6 d °C−1 on average. Such shifts are some of the most reported and predictable biological impacts of rising temperatures. Yet as climate change has marched on, phenological shifts have appeared muted over recent decades – failing to match simple predictions of an advancing spring with continued warming. The main hypothesis for these changing trends is that interactions between spring phenological cues – long‐documented in laboratory environments – are playing a greater role in natural environments due to climate change. Here, we argue that accurately linking shifts observed in long‐term data to underlying phenological cues is slowed by biases in observational studies and limited integration of insights from laboratory studies. We synthesize seven decades of laboratory experiments to quantify how phenological cue‐space has been studied and how treatments compare with shifts caused by climate change. Most studies focus on one cue, limiting our ability to make accurate predictions, but some well‐studied forest species offer opportunities to advance forecasting. We outline how greater integration of controlled‐environment studies with long‐term data could drive a new generation of laboratory experiments, built on physiological insights, that would transform our fundamental understanding of phenology and improve predictions.
The effects of combined microwave ablation and open surgery for the treatment of lung cancer‐derived thoracolumbar metastases
Authors: Zhong Guoqing , Zeng Longhui , He Yue , Zeng Xiaolong , Huang Wenhan , Yang Tao , Chu Xiao , Xiao Jin , Yin Dong , Chang Yunbing , Cheng Shi , Zhang Yu 
Published: May 2022

ObjectiveTo investigate the clinical effects of microwave ablation (MWA) in addition to open surgery for the treatment of lung cancer‐derived thoracolumbar metastases.MethodsThis was a single‐institution, retrospective, cohort study. From January 2019 to December 2020, a total of 47 patients with lung cancer‐derived thoracolumbar metastases underwent posterior spinal canal decompression and fixation surgery in our hospital. Two independent surgical teams treated these patients. One group underwent open surgery combined with MWA therapy, while the other had open surgery only (control). The pre‐ and post‐operative visual analog scale (VAS) scores and the overall survival (OS) were compared between the MWA and control groups. The Frankel Grade classification was applied for the evaluation of the post‐surgical spinal cord function. Improvement was defined as an increase of at least one rank from the pre‐operative scores. Each patient was evaluated pre‐ and post‐operatively at 48 h, 1 month, and 3‐month intervals. Data on surgical‐related complications were recorded.ResultsThirty men and 17 women were included, with an average age of 57.9 ± 11.4 years (range, 26–81 years). Twenty‐eight patients underwent MWA and were in the MWA group, and 19 patients were included in the control group. Post‐operatively all patients were followed up regularly; the median follow‐up time was 12 months (range, 3–24 months), and their median OS was 14 months. Patients in the MWA group had a lower VAS score than those in the control group at the 48‐h (1.75 ± 1.01 vs 2.47 ± 0.96, P = 0.01) and 1‐month (1.79 ± 0.92 vs 2.53 ± 1.35, P = 0.048) check‐ups. At the 3‐month evaluation, the VAS score differences between the two groups were not significant (P = 0.133). After surgery, spinal cord function improvement was not significantly different between the MWA and control groups (P = 0.515). MWA therapy combined with open surgery was not associated with increased OS compared with the control group (P = 0.492).ConclusionMWA can be an effective and safe pain‐relief method but may not extend the OS of patients with lung cancer.
A Comparative Study of a New Retractor‐Assisted WILTSE TLIF, MIS‐TLIF, and Traditional PLIF for Treatment of Single‐Level Lumbar Degenerative Diseases
Authors: Liu Huanan , Li Jiaqi , Sun Yapeng , Wang Xianzheng , Wang WeiJian , Guo Lei , Zhang Fei , Zhang Peng , Zhang Wei 
Published: May 2022

ObjectivesTo compare the clinical efficacy of a new retractor‐assisted Wiltse transforaminal lumbar interbody fusion (TLIF), minimally invasive TLIF (MIS‐TLIF), and traditional posterior lumbar interbody fusion (PLIF) in treating single‐level lumbar degenerative diseases.MethodsA retrospective study was conducted by analyzing the clinical and imaging data of consecutive patients with single‐level lumbar degenerative diseases who underwent the new retractor‐assisted Wiltse TLIF, MIS‐TLIF, or traditional PLIF. This study enrolled 87 concurrent patients between June 2016 and December 2019 (Wiltse TLIF 29 cases; MIS‐TLIF 28 cases; PLIF 30 cases). The three groups were compared for perioperative indicators (including intraoperative blood loss, postoperative drainage volume, operation time, intraoperative fluoroscopy time, bedridden time), creatine kinase (CK), visual analog score (VAS), Oswestry disability index (ODI), Japanese Orthopaedic Association (JOA) score, intervertebral fusion rate, muscle atrophy, and fatty infiltration (including ratio of multifidus atrophy and ratio of lean‐to‐total cross‐sectional area [CSA]).ResultsIntraoperative blood loss (F = 62.628, p < 0.001), postoperative drainage volume (F = 72.048, p < 0.001), and bedridden time (χ2 = 62.289, p < 0.001) were significantly lower in the MIS‐TLIF and Wiltse groups than in the PLIF group. The operative and intraoperative radiation times of the MIS‐TLIF group were significantly longer than those of the Wiltse and PLIF groups. The CK concentration in the Wiltse and MIS‐TLIF groups were significantly lower than those in the PLIF group 1 day (F = 9.331, p < 0.001) and 3 days after surgery (F = 15.967, p < 0.001). The PLIF group's back pain VAS score was higher than those of the Wiltse and MIS‐TLIF groups. The PLIF group had a higher ODI 6 months (F = 3.282, p = 0.042) and 12 months (F = 5.316, p = 0.007) after surgery and a lower JOA score than the Wiltse and MIS‐TLIF groups 6 months (F = 3.234, p = 0.044) and 12 months (F = 3.874, p = 0.025) after surgery. The ratio of multifidus atrophy in the PLIF group (41.70 ± 8.84%) was significantly higher than those of the Wiltse group (24.13 ± 6.82%) and the MIS‐TLIF group (22.35 ± 5.03%). The ratio of lean‐to‐total CSA in the PLIF group was lower than those of the Wiltse and MIS‐TLIF groups after surgery (F = 8.852, p < 0.001). MIS‐TLIF group showed longer operation time (169.11 ± 29.38 min) and intraoperative fluoroscopy time (87.61 ± 3.13 s) than the Wiltse group.ConclusionWiltse TLIF assisted by the new retractor is a more convenient and minimally invasive surgical method than the traditional PLIF and MIS‐TLIF methods, which are linked to a long learning curve and long operation and fluoroscopy time.
Practice what you teach: An approach to integrate airway education for experienced anesthesia clinicians
Authors: Daly Guris Rodrigo J. , Toy Serkan , Bruins Benjamin B. , Hu Paula , Laverriere Elizabeth K. , Oke Ayodele , Sequera‐Ramos Luis , Struyk Brian P. , Ward Christopher G. , Fiadjoe John E. , Garcia‐Marcinkiewicz Annery G. 
Published: May 2022

AbstractBackgroundThe COVID‐19 pandemic has disrupted clinician education. To address this challenge, our divisional difficult airway program (AirEquip) designed and implemented small‐group educational workshops for experienced clinicians. Our primary aim was to test the feasibility and acceptability of a small‐group, flexible‐curriculum skills workshop conducted during the clinical workday. Secondary objectives were to evaluate whether our workshop increased confidence in performing relevant skills and to assess the work‐effort required for the new program.MethodsWe implemented a 1:1 and 2:1 (participant to facilitator ratio) airway skills workshop for experienced clinicians during the workday. A member of the AirEquip team temporarily relieved the attendee of clinical duties to facilitate participation. Attendance was encouraged but not required. Feasibility was assessed by clinician attendance, and acceptability was assessed using three Likert scale questions and derived from free‐response feedback. Participants completed pre and postworkshop surveys to assess familiarity and comfort with various aspects of airway management. A work‐effort analysis was conducted and compared to the effort to run a previously held larger‐format difficult airway conference.ResultsFifteen workshops were conducted over 7 weeks; members of AirEquip were able to temporarily assume participants' clinical duties. Forty‐seven attending anesthesiologists and 17 CRNAs attended the workshops, compared with six attending anesthesiologists and five CRNAs who attended the most recent larger‐format conference. There was no change in confidence after workshop participation, but participants overwhelmingly expressed enthusiasm and satisfaction with the workshops. The number of facilitator person‐hours required to operate the workshops (105 h) was similar to that required to run a single all‐day larger‐format conference (104.5 h).ConclusionIt is feasible and acceptable to incorporate expert‐led skills training into the clinical workday. Alongside conferences and large‐format instruction, this modality enhances the way we are able to share knowledge with our colleagues. This concept can likely be applied to other skills in various clinical settings.
Molecular cytogenetic identification of a new synthetic amphiploid (Triticum timococcum, AtAtGGAmAm) with a seed setting rate comparable with that of natural Triticum zhukovskyi
Authors: Liu Xiaojuan , Yang Hang , Zhang Minghu , Liu Xin , Peng Ting , Hao Ming , Jiang Bo , Huang Lin , Ning Shunzong , Yuan Zhongwei , Chen Xuejiao , Chen Xue , Liu Dengcai , Zhang Lianquan 
Published: May 2022

AbstractTriticum timopheevii (AtAtGG) was previously cultivated in western Georgia, and Triticum zhukovskyi (AtAtGGAmAm) is a natural allohexaploid originating from hybridization of T. timopheevii and Triticum monococcum (AmAm). In this study, two synthetic amphiploids (Triticum timococcum, AtAtGGAmAm), Syn‐AtGAm‐20 and Syn‐AtGAm‐21, were developed by chromosome doubling of F1 hybrids between T. timopheevii and T. monococcum. Chromosomes of these two amphiploids were identified by fluorescence in situ hybridization (FISH) utilizing oligonucleotide probes Oligo‐pSc119.2‐1, Oligo‐pTa535‐1, Oligo‐pTa71‐2 and Oligo‐(AAC)7. Each amphiploid had 42 chromosomes derived from its parents, but the Glu‐A1mx subunits from einkorn were both not expressed. Syn‐AtGAm‐20 had low average seed setting rates of 19.86% and 20.50% in two different years, with abnormal spikes similar to those reported before. Syn‐AtGAm‐21 had normal spikes with average seed setting rates of 65.88% and 61.56% in two different years, comparable with those of natural T. zhukovskyi. However, the relationship between Syn‐AtGAm‐21 and natural T. zhukovskyi requires further study. This research provides new materials for studying the origin of T. zhukovskyi.