bluuebunny/crossref_metadata_2025_split huggingface dataset:
El Plan de Marketing Territorial: un instrumento para la gestión pública provincial (Ourense, España) / / / \ \ \ The Territorial Marketing Plan: an instrument for provincial public management (Ourense, Spain)
Authors: Del-Campo-Villares Manuel Octavio , Jardón-Ferreiro Eladio , Miguéns-Refojo Vanessa , Ferreiro-Seoane Francisco Jesús 
Published: January 2022

Resumen: Este trabajo se sitúa entre el marketing territorial y el desarrollo local aplicado a la provincia de Ourense (Galicia, España). Su objeto es identificar aquellas áreas de trabajo donde es necesario hacer un mayor hincapié? para facilitar el crecimiento y desarrollo de la provincia, y de esta forma mejorar la calidad de vida de sus ciudadanos. Para ello, se llevó a cabo un análisis en dos fases: en la primera, se diagnosticó el estado y la estructura general de la provincia mediante un amplio trabajo de campo, y el uso de distintas técnicas de recogida de datos. Todo ello permitió el reconocimiento de los puntos fuertes y débiles, que definen la identidad provincial; en la segunda fase, se diseñó el Plan de Marketing Territorial adecuado para mejorar la imagen y el posicionamiento de Ourense provincia. Ello concluyó con la identificación de cuatro ejes o grandes áreas de trabajo: economía, servicios, infraestructuras e imagen exterior e institucionalismo, las cuales dieron lugar a veinte objetivos estratégicos, que finalmente se plasmaron en veinticinco acciones específicas.

Palabras clave: Análisis DAFO, Diagnóstico Territorial, Estrategia, Políticas Publicas, Desarrollo Local.

Abstract: This work is situated between territorial marketing and local development applied to the province of Ourense (Galicia, Spain). The main objective is to identify those areas of work, where it is necessary to place greater emphasis to facilitate the development and growth of the province and therefore improve the quality of life of its citizens. For this, a two-phase analysis was carried out: in the first, the state and general structure of the province was diagnosed through extensive fieldwork and the use of different data collection techniques, which was based on the recognition of the strengths and weaknesses that define the provincial identity. In the second, a proposal of Territorial Marketing Plan was provided, in order to improve the brand positioning of Ourense. This concluded with the identification of four large areas of work: economy, services, infrastructures and foreign image and institutionalism, which derived in twenty strategic objectives, that finally culminated in twenty-five specific actions.

Key words: SWOT Analysis, Territorial Diagnosis, Strategy, Public Policies, Local Development.
Ruptura Urbana. Las relaciones entre la morfología urbana y la estructura social de L’Hospitalet de Llobregat (Barcelona, España)
Authors: Caamaño López Alejandro 
Published: January 2022

Resumen: L’Hospitalet de Llobregat continúa afrontando proyectos urbanísticos de grandes dimensiones, como la segunda fase del Plan de Dirección Urbanística Gran Vía -PDU Gran Vía-, con una inversión pública prevista de 150 millones; la configuración de Santa Eulàlia Avenue; y la proliferación de HUTs alrededor de toda la ciudad en los últimos años, o la creación del Plan de Distrito Cultural de perímetro abierto. La aparición de grandes inversiones urbanísticas y grandes cambios que ha afrontado la ciudad, generando una gran dualidad entre las zonas de Collblanc-La Torrasa, Florida-Les Planes o Pubilla Cases como eje norte de la ciudad en relación a la zona sur en la que se concentran gran parte de estos nuevos procesos urbanísticos, obliga a plantearse la distribución de la población en la ciudad según niveles de renta mediante procesos de migración forzosa y selectiva intramunicipales y extramunicipales. Examinando este caso podemos observar el aumento de la segregación residencial socioeconómica en relación al aumento del precio del alquiler y suelo e identificar los factores que explican las pautas de estructuración socioresidencial durante este periodo mediante un proceso de sistematización bibliográfica y fuentes secundarias junto un análisis cualitativo de observación directa y entrevistas a los diversos actores implicados en la ciudad.

Palabras clave: L’Hospitalet de Llobregat; ruptura urbana; migración; morfologia urbana.

Abstract: L'Hospitalet de Llobregat continues to face large-scale town projects, such as the second phase of the Gran Vía Urban Planning Plan -PDU Gran Vía-, with a planned public investment of 150 million; the configuration of Santa Eulàlia Avenue; and the proliferation of HUTs around the city in recent years, or the creation of the Cultural District Plan with open perimeter. The emergence of big urban investments and big changes that the city has faced, generating a great duality between the areas of Collblanc-La Torrasa, Florida-Les Planes or Pubilla Cases as the north axis of the city in relation to the southern area in which most of these new urban processes are concentrated, forces us to consider the distribution of the population in the city according to income levels through forced and selective migration processes intra-municipal and extra-municipal. Examining this case, we can observe the increase in socioeconomic residential segregation in relation to the increase in the price of rent and land and identify the factors that explain the patterns of the socio-residential structuring during this period through a process of bibliographic systematization and secondary sources together with a qualitative analysis of direct observation and interviews with the various actors involved in the city.

Key words: L’Hospitalet de Llobregat; urban disruption; migration; urban morphology.
Reseña. Antropoceno, reproducción de capital y comunismo
Authors: Bergua Jorge 
Published: January 2022

Resumen. Al comienzo de la presente obra, el autor conceptualiza el término Antropoceno desde la premisa de una nueva época geológica en la historia de la Tierra. En ella, sostiene, interaccionan diversas crisis desde dentro del sistema capitalista, fundamentalmente; la crisis secular de valorización del capital. Esta crisis, expone, nos coloca en una situación de emergencia planetaria (afecta simultáneamente a todas las geosferas terrestres), y tiene su origen en el modo de desarrollo y producción extractivista y fosilista, que convulsiona por la mercantilización y la reproducción de capital. Por último, apoyado en el análisis sociometabólico de reproducción del modo capitalista, propone la posibilidad de superar esta crisis a través de la organización de las sociedades que, conscientes de la coyuntura histórica, logren resolver las contradicciones en un planeta que se fractura.

Palabras clave: crisis sistémica, Antropoceno, capitalismo, reproducción de capital, comunismo.
Observatorio Territorial Turístico de Cullera (Valencia, España). Una herramienta de transferencia de información territorial
Authors: García Cardona Cristina , Ferrandis Martínez Adrián , Sánchez Cabrera José Vicente , Pérez Cosín Josep Vicent 
Published: January 2022

Resumen: La gestión local de los municipios debe velar por el interés general de todos sus ciudadanos y ciudadanas. Las ciudades afrontan importantes retos que hacen necesario un amplio conocimiento de su realidad social, económica y territorial, para tomar las decisiones estratégicas más adecuadas desde sus equipos de gobierno. El Observatorio Territorial Turístico de Cullera, que nace en el seno de la Càtedra Ciutat de Cullera, es una herramienta de transferencia de información territorial del municipio que ayuda a establecer un vínculo entre la ciudadanía y el territorio.

Palabras clave: Observatorio Territorial Turístico, Transferencia de información, Gestión Local, planificación estratégica, desarrollo local.
Economía circular de la aceituna. Proyecto de Cooperación Leader en la Comunidad Valenciana (España)
Authors: Maestrat Plana Alta GAL 
Published: January 2022

Resumen: Siete Grupos de Acción Local (GAL) de la Comunitat Valenciana se han unido para dar vida al Proyecto de Cooperación Leader “Economía Circular de la Aceituna. Aprovechamiento de subproductos de la producción de aceite de oliva”, con el fin de investigar todos los factores que hagan posible la utilización del alperujo como alimento para la cabaña de extensivo del medio rural valenciano, algo que supondría una solución más económica y adecuada que la utilización directa de piensos, y la mejora de la economía de las zonas rurales de la Comunitat Valenciana. Para ello se han desarrollado dos bloques de actuaciones, globales y zonificadas. Las actuaciones globales son aquellas que afectan a los siete GAL participantes, y las zonificadas son las que afectan solo a algunos de los GAL participantes. Entre las primeras, encontramos acciones de formación, difusión y marketing, y elaboración de documentos estratégicos. Entre las segundas, acciones concretas bien para fomentar el uso del alperujo en alimentación animal: evaluación de limitantes y alternativas de gestión, bien para el diseño de raciones con alperujo específicas para rumiantes en extensivo. Este proyecto evidencia la necesidad de concretar unos planes de viabilidad reales y locales del uso del alperujo que puedan estar avalados por el compromiso de los actores clave y que, además, puedan contar con el apoyo de las administraciones públicas.

Palabras clave: espacios rurales, desarrollo territorial, economía circular, despoblación, cooperación, LEADER.
Effects of IFIH1 rs1990760 variants on systemic inflammation and outcome in critically ill COVID-19 patients in an observational translational study
Authors: Amado-Rodríguez Laura , Salgado del Riego Estefania , Gomez de Ona Juan , López Alonso Inés , Gil-Pena Helena , López-Martínez Cecilia , Martín-Vicente Paula , Lopez-Vazquez Antonio , Gonzalez Lopez Adrian , Cuesta-Llavona Elias , Rodriguez-Garcia Raquel , Boga Jose Antonio , Elena alvarez-Arguelles Marta , Mayordomo-Colunga Juan , Vidal-Castineira Jose Ramon , Crespo Irene , Fernandez Margarita , Criado Loreto , Salvadores Victoria , Jimeno-Demuth Francisco Jose , Blanch Lluis , Prieto Belen , Fernandez-Fernandez Alejandra , Lopez-Larrea Carlos , Coto Eliecer , Albaiceta Guillermo M 
Published: January 2022

Background:Variants in IFIH1, a gene coding the cytoplasmatic RNA sensor MDA5, regulate the response to viral infections. We hypothesized that IFIH1 rs199076 variants would modulate host response and outcome after severe COVID-19.Methods:Patients admitted to an intensive care unit (ICU) with confirmed COVID-19 were prospectively studied and rs1990760 variants determined. Peripheral blood gene expression, cell populations, and immune mediators were measured. Peripheral blood mononuclear cells from healthy volunteers were exposed to an MDA5 agonist and dexamethasone ex-vivo, and changes in gene expression assessed. ICU discharge and hospital death were modeled using rs1990760 variants and dexamethasone as factors in this cohort and in-silico clinical trials.Results:About 227 patients were studied. Patients with the IFIH1 rs1990760 TT variant showed a lower expression of inflammation-related pathways, an anti-inflammatory cell profile, and lower concentrations of pro-inflammatory mediators. Cells with TT variant exposed to an MDA5 agonist showed an increase in IL6 expression after dexamethasone treatment. All patients with the TT variant not treated with steroids survived their ICU stay (hazard ratio [HR]: 2.49, 95% confidence interval [CI]: 1.29–4.79). Patients with a TT variant treated with dexamethasone showed an increased hospital mortality (HR: 2.19, 95% CI: 1.01–4.87) and serum IL-6. In-silico clinical trials supported these findings.Conclusions:COVID-19 patients with the IFIH1 rs1990760 TT variant show an attenuated inflammatory response and better outcomes. Dexamethasone may reverse this anti-inflammatory phenotype.Funding:Centro de Investigación Biomédica en Red (CB17/06/00021), Instituto de Salud Carlos III (PI19/00184 and PI20/01360), and Fundació La Marató de TV3 (413/C/2021).
Identification and validation of an epithelial mesenchymal transition-related gene pairs signature for prediction of overall survival in patients with skin cutaneous melanoma
Authors: Shi Yucang , Li Zhanpeng , Zhou Zhihong , Liao Simu , Wu Zhiyuan , Li Jie , Yin Jiasheng , Wang Meng , Weng Meilan 
Published: January 2022

Background
We aimed to construct a novel epithelial-mesenchymal transition (EMT)-related gene pairs (ERGPs) signature to predict overall survival (OS) in skin cutaneous melanoma (CM) patients.

Methods
Expression data of the relevant genes, corresponding clinicopathological parameters, and follow-up data were obtained from The Cancer Genome Atlas database. Univariate Cox regression analysis was utilized to identify ERGPs significantly associated with OS, and LASSO analysis was used to identify the genes used for the construction of the ERGPs signature. The optimal cutoff value determined by the receiver operating characteristic curve was used to classify patients into high-risk and low-risk groups. Survival curves were generated using the Kaplan–Meier method, and differences between the two groups were estimated using the log-rank test. The independent external datasets GSE65904 and GSE19234 were used to verify the performance of the ERGPs signature using the area under the curve (AUC) values. In addition, we also integrated clinicopathological parameters and risk scores to develop a nomogram that can individually predict the prognosis of patients with CM.

Results
A total of 104 ERGPs related to OS were obtained, of which 21 ERGPs were selected for the construction of the signature. All CM patients were stratified into high-and low-risk groups based on an optimal risk score cutoff value of 0.281. According to the Kaplan–Meier analysis, the mortality rate in the low-risk group was lower than that in the high-risk group in the TCGA cohort (P < 0.001), GSE65904 cohort (P = 0.006), and GSE19234 cohort (P = 0.002). Multivariate Cox regression analysis indicated that our ERGP signature was an independent risk factor for OS in CM patients in the three cohorts (for TCGA: HR, 2.560; 95% CI [1.907–3.436]; P < 0.001; for GSE65904: HR = 2.235, 95% CI [1.492–3.347], P < 0.001; for GSE19234: HR = 2.458, 95% CI [1.065–5.669], P = 0.035). The AUC value for predicting the 5-year survival rate of patients with CM of our developed model was higher than that of two previously established prognostic signatures. Both the calibration curve and the C-index (0.752, 95% CI [0.678–0.826]) indicated that the developed nomogram was highly accurate. Most importantly, the decision curve analysis results showed that the nomogram had a higher net benefit than that of the American Joint Committee on Cancer stage system.

Conclusion
Our study established an ERGPs signature that could be potentially used in a clinical setting as a genetic biomarker for risk stratification of CM patients. In addition, the ERGPs signature could also predict which CM patients will benefit from PD-1 and PD-L1 inhibitors.
Toxic clozapine level as first indication of severe, acute infection
Authors: Davis Erica A. K. , Hightower Tyler , Cinnamon Katherine Ann 
Published: January 2022

Abstract

Background
Clozapine levels can be influenced by many factors, including pharmacogenomic variability, pharmacokinetic drug interactions, and infection/inflammation. The concentration-to-dose ratio (C/D), a measure of a medication's rate of metabolism and clearance, may increase during an acute infection due to decreased medication metabolism and clearance.

Case Report
A 56-year-old White man was restarted on clozapine and titrated up to 350 mg/d with therapeutic steady-state levels (C/D 1.11) on hospital day (HD) 69. At this time, he was also being treated for COPD exacerbation. For the next month, he continued to complain of cough, but vital signs and chest x-ray remained normal. Labs were unremarkable except for occasional leukocytosis that would resolve on repeat evaluation. A routine clozapine level drawn on HD 104, resulted on day 108 and showed clozapine toxicity with C/D 4.05, although the patient was asymptomatic. After receipt of labs on day 109, showing elevated WBC count, he was immediately sent to the emergency room where he was admitted for treatment of pneumonia. On return to the state hospital, the patient was continued on 100 mg clozapine and titrated to 200 mg/d based on low drug levels. He continued to do well on 200 mg/d clozapine with C/D averaging 1.13 (range, 0.75-1.52).

Discussion
Acute infection and illness can lead to significantly increased clozapine levels and toxicity, even if symptoms of toxicity are minimal or absent. This appears to be the first report of a toxic level being the first indication of severe medical illness.
Impact on hospital-wide antipsychotic prescribing practices through physician peer comparison letters
Authors: Davis Erica A. K. 
Published: January 2022

Abstract
Peer comparison is a behavioral strategy that provides feedback to individuals on how they compare with others. It is used to improve health care quality, reduce inappropriate prescribing, and improve physician performance. There is very little data on peer comparison and the impact on system-wide prescribing practices, particularly with antipsychotics. To that end, the Maryland statewide pharmacy and therapeutics committee reviews hospital-level antipsychotic data for 5 facilities on a quarterly basis, including high doses and polypharmacy. One facility, Springfield Hospital Center, consistently stood out in 2016 as having higher rates of high doses of haloperidol, olanzapine, and quetiapine as well as patients receiving 3 or more antipsychotics. The pharmacist began to send out individual letters to the psychiatrists detailing their prescribing habits in these areas compared with other psychiatrists and the other state facilities. Over the course of 4 years, the percentage of patients on high doses of 3 antipsychotics substantially decreased. The percentage of patients on polypharmacy in the facility decreased, but not at the same rate as the other hospitals, leaving the facility even higher than the state average at the end of the 4-year period. Pharmacist-initiated physician peer comparison letters were associated with a considerable decrease in the prevalence of high-dose olanzapine, haloperidol, and quetiapine but did not appear to impact antipsychotic polypharmacy. This type of communication may be beneficial for stimulating system-wide changes in prescribing practices for high doses of antipsychotics; however, more individualized interventions are likely needed to reduce antipsychotic polypharmacy.
Chemistry and Nanotechnology‐Oriented Strategies toward Nanocellulose for Human Water Treatment
Authors: Zha Ruhua , Shi Tuo , He Liu , Zhang Min 
Published: January 2022

AbstractThere is an emerging quest for sustainable materials with good mechanical properties and economic production, while still being functionalizable. Nanocellulose stands out as a promising renewable and biocompatible nanomaterial owing to its natural abundance, and unique architectural properties. Here the current state‐of‐the‐art of the nanocellulose‐oriented self‐assembly and advanced environmental remediation is reviewed. Various construction technologies are described in detail, to present new opportunities and approaches for the application of chemistry and nanotechnology to enhance the efficiency and affordability of water treatment and wastewater reuse. Finally, several challenges and issues that need further exploration in the future are highlighted.
Releasing the Bubbles: Nanotopographical Electrocatalyst Design for Efficient Photoelectrochemical Hydrogen Production in Microgravity Environment
Authors: Akay Ömer , Poon Jeffrey , Robertson Craig , Abdi Fatwa Firdaus , Cuenya Beatriz Roldan , Giersig Michael , Brinkert Katharina 
Published: January 2022

AbstractPhotoelectrochemical devices integrate the processes of light absorption, charge separation, and catalysis for chemical synthesis. The monolithic design is interesting for space applications, where weight and volume constraints predominate. Hindered gas bubble desorption and the lack of macroconvection processes in reduced gravitation, however, limit its application in space. Physico‐chemical modifications of the electrode surface are required to induce gas bubble desorption and ensure continuous device operation. A detailed investigation of the electrocatalyst nanostructure design for light‐assisted hydrogen production in microgravity environment is described. p‐InP coated with a rhodium (Rh) electrocatalyst layer fabricated by shadow nanosphere lithography is used as a model device. Rh is deposited via physical vapor deposition (PVD) or photoelectrodeposition through a mask of polystyrene (PS) particles. It is observed that the PS sphere size and electrocatalyst deposition technique alter the electrode surface wettability significantly, controlling hydrogen gas bubble detachment and photocurrent–voltage characteristics. The highest, most stable current density of 37.8 mA cm−2 is achieved by depositing Rh via PVD through 784 nm sized PS particles. The increased hydrophilicity of the photoelectrode results in small gas bubble contact angles and weak frictional forces at the solid–gas interface which cause enhanced gas bubble detachment and enhanced device efficiency.
Visible‐Light‐Driven and Singlet Oxygen‐Mediated Synthesis of Biologically Relevant 2‐Hydroxyphenylated‐α‐Ketoamides Through Decarboxylative Amidation of 4‐Hydroxycoumarins
Authors: Brahmachari Goutam , Karmakar Indrajit 
Published: January 2022

AbstractA new synthetic strategy for accessing a diverse series of 2‐hydroxyphenylated α‐ketoamides has been achieved based on visible light (white LED/direct sunlight)‐driven photocatalytic decarboxylative amidation of 4‐hydroxycoumarins. Advantages of this new protocol include mild and energy‐efficient reaction conditions, the use of dioxygen as a reactant, and avoidance of metal catalysts. In addition, this method offers a pathway to install a biologically potent hydroxy group at C‐2 position of the phenyl ring of α‐ketoamide skeleton.
Iron‐Catalyzed Ring‐Opening/Allylation of Cycloalkyl Hydroperoxides with Allylic Sulfones
Authors: Wang Ming‐Hua , Tao Jing‐Qi , Yang Fan , Xin Hong , Gao Shu‐Xin , Guo Li‐Na , Gao Pin 
Published: January 2022

AbstractAn efficient iron‐catalyzed allylation of cycloalkyl hydroperoxides with allylic sulfones via C−C bond cleavage is presented. This protocol provides an efficient approach to a wide range of distally allylated ketones with good functional group tolerance and high regioselectivity under redox‐neutral conditions. Preliminary mechanistic study implies a radical process might be involved in this reaction.
Polarization dependence of the resonant two‐photon ionization spectra of jet‐cooled (1R,2R)‐(−)‐pseudoephedrine
Authors: Jeong Changseop , Mishra Kamal K. , Yun Jiyeon , Heo Jiyoung , Kim Nam Joon 
Published: January 2022

AbstractThe polarization dependence of the resonant two‐photon ionization (R2PI) spectra of jet‐cooled (1R,2R)‐(−)‐pseudoephedrine was investigated near the origin bands of three conformers. To obtain the difference R2PI spectra of the origin bands, R2PI signals produced by circularly polarized light (CP) were subtracted from those produced by linearly polarized light (LP), which revealed positive values for the P and R branches of the origin bands and negative values for the Q branch. To understand the different polarization behaviors of the P, Q, and R branches, expressions were derived to predict the transition probabilities of symmetric top molecules in a parallel transition. The transition probabilities varied depending on the direction of the total angular momentum J with respect to the light propagation vector. The different polarization behaviors of the rotational branches may arise from the differences in the angular distributions of the J vectors that are preferentially excited by LP and CP.