bluuebunny/crossref_metadata_2025_split huggingface dataset:
The cervical sagittal curvature change in patients with or without PCSM after laminoplasty
Authors: Qian Shengjun , Wang Zhan , Ren Ying , Chew Ian , Jiang Guangyao , Li Wanli , Chen Weishan 
Published: August 2022

ObjectiveAfter laminoplasty, the cervical sagittal curvature of some patients tend to be lordotic, this phenomenon cannot be explained by the theory of laminoplasty, and the reason remains unknown. We explored the possible role played by pinching cervical spondylotic myelopathy (PCSM) in the cervical sagittal curvature change in patients after laminoplasty.MethodsFrom April 2017 to May 2019, we studied 122 patients undergoing laminoplasty with cervical spondylotic myelopathy (CSM). All patients were divided into Group A (anterior compression only, without PCSM) and Group B (both anterior and posterior compression, with PCSM). The visual analogue scale (VAS) was used to measure pain, and modiﬁed Japanese Orthopedic Association (mJOA) score was derived. The cervical global angle (CGA) and the range of cervical motion (ROM) were compared. The clinical and imaging results were compared between Group A and Group B.ResultsAfter laminoplasty, both the mean VAS and mJOA scores improved significantly in Group A and Group B, the mJOA recovery rate of Group B was better than that of Group A (P &lt; 0.05). The mean CGA and ROM decreased in Group A, but increased in Group B. MRI revealed that the ligamentum flavum of Group A was significantly thinner than that of Group B (P &lt; 0.05).ConclusionsBecause of the hypertrophic and folded ligamentum flavum compressing the dorsal spinal cord, patients with PCSM may maintain a compulsive kyphotic posture. After laminoplasty, the cervical sagittal curvature of these patients tend to be lordotic due to the release of dorsal spinal cord compression.
Case report: A 3-year follow-up study of simultaneous bilateral total hip arthroplasty for Femoral head necrosis in a patient with Kashin-Beck Disease
Authors: Chen Xiangyu , Liu Haibin , Wang Houqing , Zheng Liqiang , Li Jiayu , Yan Lianqi 
Published: August 2022

IntroductionKashin-Beck Disease (KBD) is an endemic disease predominantly affecting joint and skeletal muscle, predisposing the articular cartilage to degeneration and necrosis. Currently,staged total hip arthroplasty is a common surgical method for advanced femoral head necrosis from KBD, but there are no reports in the literature on simultaneous bilateral total hip arthroplasty (SB-THA) for patients with KBD.Case presentationA 42-year-old male from Shaanxi Province, an endemic area, had bilateral hip pain for 4 years, with hips inversion and a crossed gait. After preoperative preparation, a SB-THA was performed by a posterolateral approach. Postoperative medication and functional exercises were administered and the patient was followed up for at least 3 years after discharge. The patient's hip mobility, hip scores and quality of life scores were recorded in detail during the follow-up.ResultThe patient stopped antibiotic treatment on the postoperative day-2, and all inflammatory indicators showed normal and started appropriate exercise, and the pain score decreased significantly. On the postoperative day-7, the patient had gradually adapted to various forms of rehabilitation exercises. He was discharged from the hospital on the postoperative day-10 and continued to be followed up. From the preoperative period to the last follow-up, the patient's bilateral hip mobility and functional scores improved significantly, and no adverse events such as hip pain, prosthesis loosening or dislocation were found at the last follow-up.ConclusionThe patient's performance was satisfactory both intraoperatively and in the early postoperative period, but the hip scores and quality of life scores began to plateau or even decline from the third year after surgery to the last follow-up, probably due to the influence of further damage to articular cartilage in other parts of the body.
Assessment of Two Streamline Curvature Correction Methods for an Elliptic Blending Turbulence Model
Authors: Yang Xianglong , Liao Zhenhao , Yang Lei 
Published: August 2022

Using two different methods, a previously developed elliptic blending model (the original STT k-ω-φ-α model) is modified for sensitization to streamline curvature. One method involves modifying the dissipation term in the turbulent dissipation equation, while the other constructs a new formulation for the turbulent kinetic energy production term based on an explicit algebraic stress model. The capabilities of the proposed models are evaluated by applying them to three flows with curved surfaces; namely, the two-dimensional (2D) infinite serpentine passage flow, the 2D U-turn duct flow, and the 2D periodic hill flow. The STT k-ω model with rotation and curvature correction (the STT k-ω-CC model) is also used for comparison. The computed results are compared with the relevant direct numerical simulation, experimental, and large eddy simulation data from the literature. It is found that the two proposed models significantly improve upon the original STT k-ω-φ-α model. Compared with the STT k-ω-CC model, the two proposed models produce better results in the 2D infinite serpentine passage flow and the 2D periodic hill flow. The proposed models are similarly competitive with the STT k-ω-CC model in the 2D U-turn duct flow.
PD-L1/pS6 in Circulating Tumor Cells (CTCs) during Osimertinib Treatment in Patients with Non-Small Cell Lung Cancer (NSCLC)
Authors: Pantazaka Evangelia , Ntzifa Aliki , Roumeliotou Argyro , Lianidou Evi , Georgoulias Vassilis , Kotsakis Athanasios , Kallergi Galatea 
Published: August 2022

The PD-1/PD-L1 axis provides CTCs an escape route from the immune system. Phosphorylation of the ribosomal protein S6 is implicated in the same pathway, following mTOR activation. The aim of the study was to investigate the expression of PD-L1 and pS6 in CTCs from NSCLC patients under Osimertinib treatment at a single cell level. CTCs were isolated using ISET from NSCLC patients’ blood [37 at baseline, 25 after the 1st cycle, and 23 at the end of treatment (EOT)]. Staining was performed using immunofluorescence. Cytokeratin-positive (CK+) CTCs were detected in 62% of patients. CK+PD-L1+CD45− and CK+pS6+ phenotypes were detected in 38% and 41% of the patients at baseline, in 28% and 32% after 1st cycle, and in 30% and 35% at EOT, respectively. Spearman’s analysis revealed statistically significant correlations between PD-L1 and pS6 phenotypes at all time points. Survival analysis revealed that CK+pS6+ (p = 0.003) and CKlowpS6+ (p = 0.021) phenotypes after 1st cycle were related to significantly decreased one-year progression-free survival (PFS12m) and PFS, respectively. CK+PD-L1+CD45−phenotype at baseline and after 1st cycle showed a trend for decreased PFS12m. Increased expression of PD-L1/pS6 in CTCs of Osimertinib-treated NSCLC patients implies the activation of the corresponding pathway, which is potentially associated with poor clinical outcomes.
Two New Species and a New Combination of the Subfamily Erythraeinae Based on Larval Stage (Acari: Trombidiformes: Erythraeidae) from China
Authors: Xu Si-Yuan , Yi Tian-Ci , Guo Jian-Jun , Jin Dao-Chao 
Published: August 2022

The species Eatoniana yangshuonicus (Haitlinger) comb. nov. is transferred from the genus Erythraeus to Eatoniana based on the basifemoral setal formula 2-2-1. Two new species, Eatoniana nanlingensis Xu and Jin sp. nov. and Erythraeus (Erythraeus) kunyuensis Xu and Jin sp. nov. are described and illustrated based on larvae. Eatoniana nanlingensis sp. nov. from the Oriental region (Guangdong Province), Er. (Er.) kunyuensis sp. nov. from the Palaearctic region (Shandong Province). An updated key to larval species of the genus Eatoniana of the world is presented.
Biofilm - forming characteristics of vancomycin - resistant <em>Enterococcus faecium vanA</em> of the epidemic clonal complex 17 isolated in a university hospital of southern Brazil
Authors: Thihara Isabella Ramos Trevizani , Gomes Ludmila Vilela Pereira , Cardoso Juscélio Donizete , Perugini Márcia Regina Eches , Tavares Eliandro Reis , Morey Alexandre Tadachi , Yamauchi Lucy Megumi , Yamada-Ogatta Sueli Fumie 
Published: August 2022

Vancomycin-resistant Enterococcus faecium (VREfm) is an important etiologic agent of healthcare-associated infections worldwide. The present study aimed to characterize the vanA-carrying VREfm isolates according to their genetic relatedness, multilocus sequence typing (MLST), biofilm-forming characteristics, and the occurrence of putative genes involved in adhesion, biofilm formation, and pili assembly. High genetic diversity among the ten vanA VREfm isolated from inpatients was observed using the rep-PCR analysis. According to the MLST analyses, four different STs were detected among the vanA VREfm isolates, with ST 412 being the most prevalent. Most of the STs detected in this study belong to Clonal Complex 17 (CC 17), a high-risk clone adapted to the hospital environment. All VREfm were capable of forming biofilm on a polystyrene surface. However, significant differences in biofilm biomass were observed among the different isolates, including those with the same ST. Scanning electron microscopy analyses of the 24-h biofilms revealed the presence of sessile cells surrounded by an extracellular polymeric substance. All VREfm harbored the atlA gene, and nine were positive for the ecbA gene. The acm, scm, and ebpC genes were detected in six isolates. Finally, the fms21/pilA gene was detected in seven isolates.
A retenção de pagamentos pela perda superveniente da regularidade fiscal e trabalhista nos contratos administrativos
Authors: Teixeira Fernando Julio 
Published: August 2022

Este artigo apresenta uma discussão hipotético-dedutiva, a partir de pesquisa bibliográfica e jurisprudencial, sobre a existência ou não em nosso sistema jurídico de permissivo legal para a Administração Pública realizar a retenção de pagamentos devidos à empresa licitante na ocorrência da perda superveniente da regularidade fiscal e trabalhista nos contratos administrativos regidos pela Lei Federal nº 8.666/93, antiga e ainda vigente Lei de Licitações e Contratos, tecendo-se também um paralelo sobre as alterações legislativas nesta temática trazidas pela nova Lei de Licitações e Contratos Administrativos (Lei Federal nº 14.133/2021). O trabalho encontra-se dividido em três partes: a primeira versa sobre o processo licitatório, princípios e regramentos, a segunda sobre perda superveniente da regularidade fiscal e trabalhista e a aplicação da retenção dos pagamentos e a terceira sobre as alterações legislativas implantadas pela nova Lei de Licitações e Contratos Administrativos. Em conclusão, chegamos ao entendimento pela impossibilidade de retenção de pagamentos pela perda superveniente da regularidade fiscal e trabalhista no curso da execução contratual sob pena de enriquecimento ilícito pela Administração Pública em razão da percepção efetiva dos produtos e/ou serviços sem a devida contraprestação pecuniária.
Biofilm formation, interaction and survival within A549 pneumocytes of Klebsiella pneumoniae clinical strains: identification of pulsotypes, multidrug-resistance and genes coding for adhesins
Authors: Nogueira Barbara Araújo , Olivella Julianna Giordano Botelho , Sued-Karam Bruna Ribeirob , Ribeiro Paula Marcele Afonso Pereira , Neves Felipe Piedade Gonçalves , Fracalanzza Sérgio Eduardo Longo , Ignácio Ana Cláudia de Paula Rosa , Guaraldi Ana Luíza de Mattos 
Published: August 2022

Klebsiella pneumoniaehas become one of the major causes of hospital-acquired infections over decades due to the spread of virulent clones harboring resistant genes to multiple antimicrobial agents. The aim of this study was to investigate phenotypic and genotypic features of virulence mechanism expressed by K. pneumoniae clinical isolates of different PFGE types, including biofilm formation, interaction with pneumocytes A549 lineage and experimental infection by using C. elegans nematodes. A total of 17 K. pneumoniae strains were isolated from different clinical specimens including blood, urine and respiratory infections. In this present study, 11 strains presented a varied multidrug-resistance profile harboring resistance genes coding for betalactams, aminoglicosydes, fluorquinolones and carbapenemases. PFGE analysis demonstrated the presence of four distinct pulsotypes among K. pneumoniae strains harboring virulence genes for siderophores and fimbiae type 1 and type 3. High adherence and biofilm formation were positively correlated for both polystyrene and glass surfaces in all K. pneumoniae strains analyzed. K. pneumoniae clinical strains showed the ability of adherence, internalization and persistence within human pulmonary epithelial A549 cell line, at different levels. Respiratory infections demonstrated a higher heterogeneity of PFGE types and levels of adherence, intracellular survival and persistence.K. pneumoniae strains were also submitted to Carnohabidits elegans in vivo infection model and data showed that after 24 hr almost 10% of urine-culture isolates worms were dead evidencing virulence profile. Notably, K. pneumoniae strains, presenting virulence genes, was significantly more virulent than those who did not presented any virulence gene after 5 days (survival >60% and >40%).
Avaliação da germinação de semente de coentro (Coriandrum sativum L.) Em laboratório e bandeja
Authors: Brandão Gustavo Rezende , Souza Breno Hilário de , Martins Matheus Ribeiro , Souza Yasmin Gomes de , Moraes Maria Joselma de , Barros Ruth Ribeiro Naves 
Published: August 2022

O coentro (Coriandrum sativum L.) é uma hortaliça herbácea anual pertencente à família Apiaceae, considerada cultura de fundo de quintal, mas é cultura de grande importância socio econômica. Em razão disso, objetivou-se nesse trabalho comparar taxa de germinação, em bandeja e em laboratório, com os valores apresentados comercialmente na embalagem das sementes. Realizou-se o teste padrão de germinação conforme a Regra de Análises de Sementes com 4 repetições e 50 sementes, e a germinação em bandeja de plástico foram usadas 4 bandejas com 50 células onde foram preenchidas com substrato que era uma mistura de turfa, vermiculita e calcário em proporções iguais, sendo que a germinação foi realizada manualmente com uma semente por célula. Tanto a germinação pelo método padrão de laboratório quanto a germinação em bandejas não atingiram a germinação informada no rotulo da embalagem comercial das sementes.
Evidências sobre o uso de leite materno no tratamento dermatológico da pele do recém-nascido
Authors: Pissolatto Gabrielle Grecov , Toqueton Tainá Rodrigues , Mendes Filho Edivaldo Bezerra , Zanoni Rodrigo Daniel , Pacheco Amanda Mota , Borges Isabela Costa , Gonçalves Ildiane Aparecida , Yonemoto Ana Cláudia Ferreira , Araujo e Sá Gonçalves Hélida Suzana Batista , Santos Maria Yuska Nathielly Almeida , Lima Ariel Ferreira , Kador e Silva Caio Livio , Melo Lucas Benício Lourenço , Malta Cindy Lima Vidigal , Lemos Pedro Negreiros , De Vasconcelos Fabiola Monteiro , Mendonça Marina Resende , Savoi Ana Paula Magalhães Teixeira , Rodrigues Thays Silva , Meneghetti Felipe Dias , Dias Henrique Carmelo , Baldini João Carlos , Drummond Júnior Délio Guerra , Bezerra Geovana Christina Isidoro , Rodrigues Carolyna Gonçalves , Bezerra Luiza Cristina Pereira Bezerra , Farias Renata Gabriela Torres , Quintana Eylen Naivis Blanco 
Published: August 2022

O presente estudo tem como objetivo analisar as evidências sobre o uso de leite materno no tratamento dermatológico da pele do recém-nascido. A pesquisa foi desenvolvida com base em uma Revisão Sistemática da Literatura (RSL). A pesquisa foi realizada na Biblioteca Virtual do Ministério da Saúde (BVS) que indexa artigos de diferentes bases de dados como Scielo, Lilacs e MedLine e na PubMed. Como critérios de inclusão foi considerado ser disponível em formato completo e publicado nos últimos dez anos (2012-2022). Foram excluídos estudos que não respondessem o tema de pesquisa ou que estivessem duplicados nas bases de dados. O uso do leite materno como tratamento dermatológico de pele é potencial, porém, os estudos ainda são escassos e inconclusivos, fazendo-se importante que estudos sejam realizados para que se possa sanar dúvidas sobre o uso do leite materno, considerando ser um tratamento natural e de baixo custo.
Filiação multiparental
Authors: Azevedo Flávia Regina Porto , Alencar Ana Cláudia Gean de , Teixeira Enne Juliane , Carvalho Isabel Marques de , Corrêa Jhennyfer Beatriz da Silva , Nascimento Lucas Meireles do , Corrêa Roberto Mayco Siqueira , Amorim Roberto Vinicius Viana 
Published: August 2022

O presente artigo tem como objetivo geral apresentar aspectos gerais da socioafetividade, princípio da afetividade e filiação multiparental. Esta pesquisa parte da análise do reconhecimento jurídico da possibilita que um indivíduo tenha dupla maternidade ou paternidade, visando legitimar a relação entre pais e filhos que não são consanguíneos, mas fundado na convivência consagrada pelas ligações afetivas. A metodologia utilizada é de pesquisa qualitativa, através da revisão bibliográfica e mapeamento documental, seguida da abordagem descritiva analítica que traçará a evolução histórico-jurídica de filiação, sendo apontados os principais avanços legislativos e jurisprudenciais alcançados. Por fim, conclui-se que o artigo alcançou o objetivo geral, tendo discorrido sobre o reconhecimento da filiação multiparental, o instituto da socioafetividade e o valor jurídico do princípio da afetivade no direito de família contemporâneo.
Marketing strategies of business systems in global environment
Authors: Parkhomenko Nataliia 
Published: August 2022

Introduction. The operation and development of business systems in international markets under pressure from competitors requires the application of strategic approaches to marketing management. The lack of a sound marketing strategy in the global environment leads to the loss of competitive positions, financial problems, unprofitable activities, etc. in domestic and foreign markets. Given the fact that in 2021 export and import operations were carried out with 166 partner countries (according to Ukrstat), the validity of the choice of marketing strategy in foreign markets is a very important issue and needs research. The purpose of the article is the process of formation and implementation of marketing strategies of the business systems in a global environment.Methods. In the process of research for the validity of the provisions presented in the article, a set of general scientific and special methods was used, in particular: historical and logical - in the process of studying the theoretical foundations of marketing strategy; analysis and synthesis - to determine the dependence of marketing strategy on the type of market and export products, to determine the relationship between marketing strategy and the degree of coverage of the international market in the global environment; matrix analysis to build a matrix of marketing strategies to enter international markets; process approach - in determining the stages of development and implementation of marketing strategy of business systems in the global environment and the formation of the algorithm of marketing activities in the formation and implementation of marketing strategy of business systems: graphical method - to visualize the results of analytical research; abstract-logical- for theoretical generalization and formulation of conclusions.Results. The article specifies the essence of the concept of «marketing strategy of business systems», considers the dependence of marketing strategy on the type of market and export products. The characteristic of marketing strategies of entering international markets is presented. The relationship between marketing strategy and the degree of coverage of the international market in the global environment is identified. The advantages and disadvantages of marketing strategies to enter international markets are described. The process of development and implementation of marketing strategy of business systems in the global environment is formed. The algorithm of marketing measures in the process of formation and implementation of marketing strategy of business systems is presented.Perspectives. The conducted research creates a basis for further improvement of the methodology of evaluation of strategic marketing alternatives in the implementation of international activities by enterprises.
Accounting and audit of electronic transactions in metaverses
Authors: Muravskyi Volodymyr , Denchuk Pavlo , Reveha Oleh 
Published: August 2022

Introduction. The latest stage in the development of the Internet is the active use of VR and AR technologies, which in the context of virtualization of information processes leads to the spread of meta-environments. The functioning of metaverses, which are integrated information environments of virtual communications, is associated with the emergence and circulation of intangible objects, which requires the improvement of their accounting and auditing. The fundamental basis of financial and economic activities in the metaverses are electronic transactions, so it is important to improve their accounting and control in the management of enterprises. The main aim is to research the prospects for improving the accounting and auditing of electronic transactions, which provide for the formation of contractual relationships, their implementation and payment using cryptocurrencies in the metaverses.Methods.In the process of the article purpose realization the system, innovative, institutional approaches and methods of economic and mathematical modeling, bibliographic and comparative analysis are used.Results. The influence of the peculiarities of financial and economic activity in metaverses on the method of accounting is investigated. Recognition of NFT as an accounting object using variable methods of their estimation in metaverses is determined: initial value according to past identification of cost components, fair value through current valuation, market value according to market value and prospective value.The necessity of using audit control methods to ensure the trust of participants in electronic transactions in meta-environments, as well as to confirm the accuracy of their reporting and other accounting information. A method of identifying electronic transactions has been developed, which has the following features: trade scams; legalization of money obtained illegally; use by attackers. The method of auditing the enterprises activities in the metaverses has been improved: introduction of accounting outsourcing in the field of financial accounting of electronic transactions; separation of information flows, which relate only to virtual financial and economic operations in metaverses; research of the internal control service of enterprises, assessment of current experience and training of staff to work with specific virtual accounting objects; formation of financial statements reflecting intangible assets related to the functioning of meta-environments.Perspectives. It is determined that further research is needed to improve the taxonomy of standard financial reporting to fully and accurately reflect the new accounting objects of the metaverses.