bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multimorbidity and overall survival among women with breast cancer: Results from the South African breast cancer and HIV outcomes study
Authors: Ayeni Oluwatosin A. , Joffe Maureen , Mapanga Witness , Chen Wenlong Carl , O’Neil Daniel S. , Phakathi Boitumelo , Nietz Sarah , Buccimazza Ines , Čačala Sharon , Stopforth Laura W. , Jacobson Judith S. , Crew Katherine D. , Neugut Alfred I. , Ramiah Duvern , Ruff Paul , Cubasch Herbert , Chirwa Tobias , McCormack Valerie , Micklesfield Lisa K. , Norris Shane A. 
Published: April 2022

Abstract
Background
Breast cancer survival in sub-Saharan Africa (SSA) is low, but when diagnosed with breast cancer, many women in SSA also have other chronic conditions. We investigated the impact of multimorbidity (≥ 2 other chronic conditions) on overall survival among women with breast cancer in South Africa.
Methods
Between July 1, 2015 and December 31, 2019, we enrolled women newly diagnosed with breast cancer at six public hospitals participating in the South African Breast Cancer and HIV Outcomes (SABCHO) Study. We examined seven chronic conditions (obesity, hypertension, diabetes, HIV, cerebrovascular diseases (CVD), asthma/chronic obstructive pulmonary disease, and tuberculosis), and we compared socio-demographic, clinical, and treatment factors between patients with and without each condition, and with and without multimorbidity. We investigated the association of multimorbidity with overall survival using multivariable Cox proportional hazard models.
Results
Of 3,261 women included in the analysis, 45% had multimorbidity; obesity (53%), hypertension (41%), HIV (22%), and diabetes (13%) were the most common individual conditions. Women with multimorbidity had poorer overall survival at 3 years than women without multimorbidity in both the full cohort (60.8% vs. 64.3%, P = 0.036) and stage groups: stages I-II, 80.7% vs. 86.3% (p = 0.005), and in stage III, 53.0% vs. 59.4% (p = 0.024). In an adjusted model, women with diabetes (hazard ratio (HR) = 1.20, 95% confidence interval (CI) = 1.03–1.41), CVD (HR = 1.43, 95% CI = 1.17–1.76), HIV (HR = 1.21, 95% CI = 1.06–1.38), obesity + HIV (HR = 1.24 95% CI = 1.04–1.48), and multimorbidity (HR = 1.26, 95% CI = 1.13–1.40) had poorer overall survival than women without these conditions.
Conclusions
Irrespective of stage, multimorbidity at breast cancer diagnosis was an important prognostic factor for survival in our SABCHO cohort. The high prevalence of multimorbidity in our cohort calls for more comprehensive care to improve outcomes for South African women with breast cancer.
Mesenteric adipose tissue-derived Klebsiella variicola disrupts intestinal barrier and promotes colitis by type VI secretion system
Authors: Gong Junli , Yin Shengmei , Wu Jinjie , Liu Chen , Luo Zhanhao , Cheng Wai Ming , Yu Jing , He Zhen , Lan Ping 
Published: April 2022

Abstract
Background:
Mesenteric adipose tissue (MAT) in Crohn’s disease (CD) is associated with transmural inflammation. Extended mesenteric excision can reduce surgical recurrence and improve long-term outcomes. These findings indicate that MAT plays an important role in the pathogenesis of CD. Bacterial translocation has been reported to occur in CD-MAT, but the mechanisms by which translocated bacteria lead to intestinal colitis remain unclear. This study aimed to characterize CD-MAT-specific bacteria and explore their roles in promoting intestinal inflammation.
Methods
We utilized 16S rRNA gene sequencing and culture-omics to characterize the translocated viable bacteria in MAT from CD. The pro-inflammatory role of the identified candidate bacteria was examined using a co-culture assay in vitro and in a colitis mouse model in vivo. The type VI secretion system (T6SS) is thought to promote the pro-inflammatory effect, and a CRISPR interference system was employed to knockdown a core gene expression in T6SS.
Results
We report that members of Enterobacteriaceae were enriched in CD-MAT compared with non-CD controls. Viable Klebsiella variicola in Enterobacteriaceae was identified exclusively in CD-MAT, which induces a pro-inflammatory response in vitro and exacerbates colitis in mice. This is the first evidence that colitogenic K. variicola exists in the mesenteric tissue. Active T6SS was found in the K. variicola genome, which could impair the intestinal barrier by inhibiting the ZO-1 expression. Dysfunction of T6SS alleviated the inhibitory effect of K. variicola on ZO-1 expression and attenuated colitis in mice. Importantly, we validated that K. variicola and T6SS were enriched in the gut microbiome of patients with CD, further confirming that they are closely related to the occurrence of CD.
Conclusions
CD mesenteric adipose tissue-derived K. variicola can disrupt the intestinal barrier and promote intestinal colitis induced by T6SS.
Dynamic reconstruction of anal sphincter with camera shutter style double-opposing gracilis flaps and biofeedback training
Authors: Wong Allen Wei-Jian , Tan Grace Hui-Min , Feng Jiajun , Kok Yee Onn , Koh Frederick Hong-Xiang , Chew Min Hoe 
Published: April 2022

Abstract
Purpose Fournier’s gangrene is a life-threatening infection which require prompt recognition, early surgical debridement of unhealthy tissue, and initiation of broad-spectrum antibiotics. Relook debridement are usually performed until all the devitalized tissue has been removed. Involvement of the anal sphincter may result in significant morbidity such as permanent incontinence. Dynamic reconstruction of the anal sphincter has always been one of the holy grails in the field of pelvic reconstruction. Method We demonstrate a new method of camera shutter style double-opposing gracilis muscle flaps that allows dynamic sphincteric function without the need for electrostimulation. With biofeedback training, the patient is able to regain dynamic continence, and return to function without a stoma.Results The patient was able to reverse his stoma 13 months after the initial insult and reconstruction with biofeedback training without the use of electrostimulation. ConclusionWith the inset of bilateral gracilis muscle flap in a double opposing, camera shutter fashion around the anus, reconstruction of anal sphincter can be successful without the use of electrostimulation. Intensive biofeedback training is required after surgery to achieve an acceptable anal resting and squeeze pressure before the reversal of stoma.
Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer’s disease
Authors: Muñoz-Moreno Emma , Simões Rui Vasco , Tudela Raul , López-Gil Xavier , Soria Guadalupe 
Published: April 2022

Abstract
Background: Brain damage associated with Alzheimer's disease (AD) occurs even decades before the symptomatic onset, raising the need to investigate its progression from prodromal stages. In this context, animal models that progressively display AD pathological hallmarks (e.g. TgF344-AD) become crucial. Translational technologies, such as magnetic resonance spectroscopy (MRS), enable the longitudinal metabolic characterization of this disease. However, an integrative approach is required to unravel the complex metabolic changes underlying AD progression, from early to advanced stages.Methods: TgF344-AD and wild-type (WT) rats were studied in vivo on a 7 Tesla MRI scanner, for longitudinal quantitative assessment of brain metabolic profile changes using MRS. Disease progression was investigated at 4 time points, from 9 to 18 months of age, and in 4 regions: cortex, hippocampus, striatum, and thalamus.Results: Compared to WT, TgF344-AD rats replicated common findings in AD patients, including decreased N-acetylaspartate in the cortex, hippocampus and thalamus, and decreased glutamate in the thalamus and striatum. Different longitudinal evolution of metabolic concentration was observed between TgF344-AD and WT groups. Namely, age-dependent trajectories differed between groups for creatine in the cortex and thalamus and for taurine in cortex, with significant decreases in Tg344-AD animals; whereas myo-inositol in the thalamus and striatum showed greater increase along time in the WT group.Additional analysis revealed divergent intra- and inter-regional metabolic coupling in each group. Thus, in cortex, strong couplings of N-acetylaspartate and creatine with myo-inositol in WT, but with taurine in TgF344-AD rats were observed; whereas in the hippocampus, myo-inositol, taurine and choline compounds levels were highly correlated in WT but not in TgF344-AD animals. Furthermore, specific cortex-hippocampus-striatum metabolic crosstalks were found for for taurine levels in the WT group but for myo-inositol levels in the TgF344-AD rats.Conclusion: With a systems biology perspective of metabolic changes in AD pathology, our results shed light into the complex spatio-temporal metabolic rewiring in this disease, reported here for the first time. Age- and tissue-dependent imbalances between myo-inositol, taurine and other metabolites, such as creatine, unveil their role in disease progression, while pointing to the inadequacy of the latter as an internal reference for quantification.
Lumbar ossification of the ligamentum flavum is associated with the spread of ossification to the entire spinal ligament
Authors: Nakabachi Kazuha , Endo Tsutomu , Takahata Masahiko , Fujita Ryo , Koike Yoshinao , Suzuki Ryota , Hasegawa Yuichi , Murakami Toshifumi , Yamada Katsuhisa , Sudo Hideki , Terkawi Mohamad Alaa , Kadoya Ken , Iwasaki Norimasa 
Published: April 2022

Abstract
Patients with ossification of the ligamentum flavum (OLF) in the lumbar spine may be at high risk of developing concomitant ossification of the entire spinal ligament, but the etiology remains unclear. We investigated the propensity for spinal ligament ossification in asymptomatic subjects with lumbar OLF using the data of 595 Japanese individuals receiving medical check-ups, including computed tomography (CT) scanning. The severity of OLF (total number of intervertebral segments with OLF) of the entire spine on CT was quantified using an OLF index. Subjects with OLF were grouped according to this index: localized OLF (n = 138), intermediate OLF (n = 70), and extensive OLF (n = 31). The proportion of subjects with lumbar OLF increased with increasing OLF index (localized 13.7%, intermediate 41.4%, and extensive 70.9%). Multiple regression analysis found that lumbar OLF index was associated with thoracic OLF index, and co-existence of ossification of the posterior longitudinal ligament (OPLL) of the thoracic and lumbar spine. This study showed that subjects with more multilevel lumbar OLF were more likely to develop multilevel thoracic OLF and to have coexisting OPLL. Patients with lumbar OLF may be a distinctive subgroup with a strong tendency to ossification of the entire spinal ligament.
Response to bridge phase treatment in Medication Overuse Headache
Authors: Togha Mansoureh , Martami Fahimeh , Alikhani Reyhaneh , Saatchi Mohammad , Fattahi Mohammad-Reza 
Published: April 2022

Abstract
Objective: Withdrawal of the overused drugs in medication overuse headache (MOH) can contribute to severe rebound headache and many other symptoms. In this regard, some centers perform bridge therapy during the days of withdrawal to manage the rebound headache and withdrawal symptoms resulting from the discontinuation of the offending drug. To investigate the response to treatment during bridge therapy and the association between different risk factors and response to therapy in patients with MOH.Method: A total of 178 MOH patients with a mean age of 43.29 years and at least one failed outpatient course of treatment was evaluated in the current retrospective cross-sectional study. We investigate the effectiveness of different medications administered during the bridge phase as well as the association between response to treatment and several risk factors. Response to treatment was defined as an improvement of more than 50% in attack duration or intensity 72 hours after receiving treatment.Results: In our MOH series, all patients who received methylprednisolone and about 70% of those who were treated with celecoxib during bridge therapy, had a response rate of more than 50%. Additionally, MOH duration was significantly shorter in patients with a high response to treatment compared to a low response group.Conclusion: Our finding suggests that methylprednisolone and celecoxib with high response rates could be good choices as bridge phase therapy in MOH patients. The inverse relationship between the duration of MOH and response to treatment also emphasizes the importance of early diagnosis and treatment of MOH.
KHIYAR AL-RU’YAH ON ONLINE TRANSACTIONS; AN ANALYSIS CONTEMPORARY MUAMALAH MALIYAH
Authors: Syaichoni Ahmad , Setiawan Didik 
Published: April 2022

This research is backed by the phenomenon of online transactions conducted by the people of the modern era. Online transactions emerge due to the development of technology and information that can help human beings buy and sell transactions efficiently. However, online transactions pose an individual problem as fraud. Islam governs that every transaction should prioritize a mutual attitude so that no party is harmed. Islam guarantees that all forms of transactions must be free from anything that could harm either party. This article will discuss Islam's concept to protect the parties in the transaction, especially in online transactions. This research is a research library with a normative juridical approach. The data analysis used is content analysis and critic analysis. This research can conclude that al-ru'yah may be applied to online transactions as a form of collateral protection provided to the consumer. Khiyar al-ru'yah attempts to ensure that the consumer knows the goods are transacted so that no party is harmed.
A new concept of a rotating hollow fibre membrane module:impact of rotation on fine-bubble aeration
Authors: Mahdariza Fathul , Domingo Rimoldi Ignacio , Henkel Jochen , Morck Tobias 
Published: April 2022

Abstract
A new concept of a rotating membrane module in a membrane bioreactor (MBR) system was tested for its effect on oxygen transfer in clean water and wastewater. The membrane module consists of horizontally aligned hollow fibres connected to the vertically positioned permeate tube which rotates. The results indicated that oxygen transfer can be improved by up to 50% at the highest applied rotational speed (50 rpm) and that the additional energy demand required for the rotation can be compensated by the enhanced oxygen transfer. However, at the highest rotational speed (50 rpm), the fine bubbles bypassed the MBR module, and, consequently, could not contribute to any cleaning effect. The α-factors at different rotational speeds showed similar results. This indicates that the depletion was caused neither by surfactants nor by viscosity phenomena but rather by the floc/solid holdup of the sludge.
Cadeia Curta Agroalimentar Sustentável do Feijão: Sob a Ótica do Movimento Slow Food
Authors: Brusamolin Jr Leonardo Afonso , Sampaio Carlos Alberto Cioce , Santos Luciane Cristina Ribeiro dos 
Published: April 2022

O presente artigo tem por objetivo analisar a cadeia curta agroalimentar sustentável do feijão, produto consumido/comercializado no restaurante Quintana (Curitiba, Brasil). A pesquisa classifica-se como exploratória, de viés qualitativo e cunho descritivo a partir de um estudo de caso. Os resultados apontam que a cadeia curta agroalimentar do feijão, no tocante à sustentabilidade, se apresenta com características diferentes e próprias em cada elo da cadeia. Os princípios do Slow Food no que se refere a garantir um alimento “bom”, “limpo”, “justo”, possui relação direta com os impactos positivos em relação à sustentabilidade ambiental, econômica, social, espacial e cultural. Do mesmo modo, a cadeia se comporta como arranjo socioprodutivo, conforme estabelecidos nas experiências de ecossocioeconomias, e apresenta-se como estratégia para garantir sua governança. Como conclusão, os princípios e valores do movimento Slow Food, foram identificados e demonstrados como suporte para a operação do Restaurante Quintana e o desenvolvimento da ecogastronomia.
Antimicrobial Activity an Physicochemical Characterization of Extracts and Fractions of Rosmarinus officinalis and Origanum vulgare
Authors: Chaul Luiza Toubas , Alves Virgínia Farias , Sá Stone de , Oliveira Leandra de Almeida Ribeiro , Fiuza Tatiana de Sousa , Torres Ieda Maria Sapateiro , Conceição Edemilson Cardoso da , Paula José Realino de 
Published: April 2022

Rosmarinus officinalis L. (Lamiaceae) is a shrubby woody with bittersweet taste, used in chips, broths, desserts, cookies, jams, fruit salads, and marmalades. Origanum vulgare L. (Lamiaceae) is a small plant used in meats, salads, soups, rice, potatoes and boiled eggs, as well as for perfuming and flavoring oils. Both have medicinal and aromatic properties. The aims of this study were: characterize, standardize herbal drugs, crude ethanol extracts and concentrated extracts of R. officinalis and O. vulgare, determine the polyphenols, tannins, flavonoids content; quantify the rosmarinic acid; evaluate the antimicrobial activity of rosmarinic acid, extracts, fractions of R. officinalis and O. vulgare against foodborne and clinical strains. The antimicrobial activity was evaluated by the broth microdilution method. The hexane and dichloromethane fractions of R. officinalis and O. vulgare and rosmarinic acid exhibited good inhibitory activity against some Gram-positive bacteria and food isolates. Ethyl acetate fraction of R. officinalis, concentrated extract, and fractions of O. vulgare and rosmarinic acid presented good inhibitory activity against Cryptococcus. These fractions have promising potential in the control of food pathogens and they can be used in the future as an alternative natural preservative in the industry.
Demographic, Clinical, and Investigational Characteristics of COVID-19-
related Guillain-Barré Syndrome with Differences from Typical and
Another Virus-related Guillain-Barré Syndrome
Authors: Singh Jitendra , Kumar Nilesh , Dinkar Anju 
Published: April 2022

Backgrounds:
SARS-CoV-2 infection typically presents with fever and respiratory symptoms.
Besides this, COVID-19-related central and peripheral nervous system manifestations are emerging.

Objectives:
This study summarises the demographics, clinical profiles, laboratory findings, management
strategies, and outcomes in a large number of patients with COVID-19-related GBS and its variants.
We also compared its clinical profile with Zika and dengue virus-related GBS.

Methods:
The authors carried out a literature search up to Dec 31, 2020, in MEDLINE, PubMed,
SCOPUS, Cochrane database, and Google Scholar for all published articles.

Results:
The study identified 54 different types of articles consisting of 70 cases from 17 countries
worldwide. A maximum of 15 cases (21.4 %) were identified from Italy, followed by the USA (12;
17.1 %), Spain (11; 15.7 %), and Iran (10; 14.3 %). The age group that was more than 60 years had the
most cases, i.e., 32 (45.7 %), followed by the age group 40-60 with 25 cases (35.7 %) with a male to
female ratio of 2. Maximum cases were treated with IVIG infusion 58 (82.9 %), followed by Plasma
exchange 13 (18.6 %) cases. Out of 70 cases, 7 (10 %) cases were manifested as Miller-Fisher syndrome.
The most predominant electrodiagnostic variant was demyelinating neuropathy in 41 (73.21 %)
cases. The outcome reported in 67 cases was survival in 63 (90 %) cases and death in 4 (5.7 %) cases.

Conclusion:
Covid-19-related GBS were reported worldwide with a better outcome. Both postinfectious
and parainfectious patterns were reported. Early recognition with prompt management of GBS
can prevent further severe morbidity and mortality.
Social Networking Service, Patient-Generated Health Data, and Population Health Informatics: National Cross-sectional Study of Patterns and Implications of Leveraging Digital Technologies to Support Mental Health and Well-being
Authors: Ye Jiancheng , Wang Zidan , Hai Jiarui 
Published: April 2022

Background
The emerging health technologies and digital services provide effective ways of collecting health information and gathering patient-generated health data (PGHD), which provide a more holistic view of a patient’s health and quality of life over time, increase visibility into a patient’s adherence to a treatment plan or study protocol, and enable timely intervention before a costly care episode.

Objective
Through a national cross-sectional survey in the United States, we aimed to describe and compare the characteristics of populations with and without mental health issues (depression or anxiety disorders), including physical health, sleep, and alcohol use. We also examined the patterns of social networking service use, PGHD, and attitudes toward health information sharing and activities among the participants, which provided nationally representative estimates.

Methods
We drew data from the 2019 Health Information National Trends Survey of the National Cancer Institute. The participants were divided into 2 groups according to mental health status. Then, we described and compared the characteristics of the social determinants of health, health status, sleeping and drinking behaviors, and patterns of social networking service use and health information data sharing between the 2 groups. Multivariable logistic regression models were applied to assess the predictors of mental health. All the analyses were weighted to provide nationally representative estimates.

Results
Participants with mental health issues were significantly more likely to be younger, White, female, and lower-income; have a history of chronic diseases; and be less capable of taking care of their own health. Regarding behavioral health, they slept <6 hours on average, had worse sleep quality, and consumed more alcohol. In addition, they were more likely to visit and share health information on social networking sites, write online diary blogs, participate in online forums or support groups, and watch health-related videos.

Conclusions
This study illustrates that individuals with mental health issues have inequitable social determinants of health, poor physical health, and poor behavioral health. However, they are more likely to use social networking platforms and services, share their health information, and actively engage with PGHD. Leveraging these digital technologies and services could be beneficial for developing tailored and effective strategies for self-monitoring and self-management.