bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconstructing the epidermal proteolytic cascades in health and disease
Authors: Sotiropoulou Georgia , Zingkou Eleni , Pampalakis Georgios 
Published: February 2022

AbstractThe epidermis is the outer stratified epithelium of the skin, forming the physical barrier that is indispensable for homeostasis. Epidermal proteolysis, mainly but not exclusively executed by kallikrein‐related peptidases (KLKs), is tightly regulated to ensure maintenance of physiological skin renewal and an intact skin barrier. Perturbation of epidermal proteolytic networks is implicated in a wide array of rare and common skin pathologies of diverse genetic backgrounds. Recent studies of monogenic human skin diseases and newly developed animal models have revealed new mechanisms of regulation of proteolytic pathways in epidermal physiology and in disease states. These new data have challenged some accepted views, for example the role of matriptase in epidermal desquamation, which turned out to be restricted to mouse skin. The significance of PAR2 signaling in skin inflammation should also be reconsidered in the face of recent findings. Cumulatively, recent studies necessitate a sophisticated redefinition of the proteolytic and signaling pathways that operate in human skin. We elaborate how epidermal proteolysis is finely regulated at multiple levels, and in a spatial manner that has not been taken into consideration so far, in which specific proteases are confined to distinct epidermal sublayers. Of interest, transglutaminases have emerged as regulators of epidermal proteolysis and desquamation by spatially fixing endogenous protease inhibitors, constituting regulatory factors that were not recognized before. Furthermore, new evidence suggests a link between proteolysis and lipid metabolism. By synthesis of established notions and recent discoveries, we provide an up‐to‐date critical evaluation and synthesis of current knowledge and the extended complexity of proteolysis regulation and signaling pathways in skin. © 2022 The Pathological Society of Great Britain and Ireland.
High‐strength wood‐based composites via laminated delignified wood veneers with different adhesive contents for structural applications
Authors: Zou Miao , Tang Qiheng , Guo Wenjing 
Published: February 2022

AbstractThe processing of natural wood into a high‐performance wood‐based composite to broaden the potential applications of wood can be achieved by various techniques using bulk wood as a raw material. However, attention has seldom been paid to the use of wood veneers for preparing high‐performance structural materials. In this study, delignified birch veneers are used as raw materials to fabricate high‐strength delignified wood‐based laminated composites (DWLCs) with phenol‐formaldehyde (PF) resin as adhesive. The DWLCs with a PF resin content of 40% had high mechanical properties and displayed flexural and tensile stress of 405.8 and 324.4 MPa, respectively. The flexural and tensile stress are 1.24 and 1.21 times higher than those of natural wood‐based laminated composites (WLCs). And we confirmed that partial delignification could contribute to enhancing the mechanical properties of high‐strength wood‐based composites. By using scanning electron microscopy (SEM), and energy‐dispersive spectroscopy (EDS), the strengthening mechanisms of the high‐performance DWLCs were investigated. Due to both the surface of the cell lumen and cell walls being filled with PF resin, the wood microstructure was cured under high pressure so that the DWLCs were enhanced.
Prediction of enantioselectivity in thiol addition to imines catalyzed by chiral phosphoric acids
Authors: Yu Xinliang 
Published: February 2022

AbstractPredicting enantioselectivities in asymmetric catalytic reactions through chemometric approach is a challenging area. In this paper, quantitative structure−selectivity relationship (QSSR) models were successfully developed for thiol addition to N‐acylimines catalyzed by chiral phosphoric acids. Ten Dragon molecular descriptors calculated from thiols and phosphoric acid catalysts were used to correlate with 1075 enantioselectivities ΔΔG. Machine learning algorithms, support vector machine (SVM) and random forest (RF), were adopted to build QSSRs after descriptor subset selection based on the multiple linear regression technique. The SVM and RF models, respectively, have coefficient of determination R2 of 0.925 and 0.944 for the training set, and of 0.837 and 0.851 for the test set. Both SVM and RF models were subjected to internal and external validation and estimation in prediction ability and systematic error.
Impact of the family communication environment on burden and clinical communication in blood cancer caregiving
Authors: Campbell‐Salome Gemme , Fisher Carla L. , Wright Kevin B. , Lincoln Greg , Applebaum Allison J. , Sae‐Hau Maria , Weiss Elisa S. , Bylund Carma L. 
Published: February 2022

AbstractObjectiveWe examined the effects of the family communication environment (conversation orientation) on adult child caregivers' burden and clinical interactions and if the effects are mediated by openness to communicate about cancer, avoidant cancer communication, and social support (SS).MethodCaregivers of a parent diagnosed with a blood cancer (N = 121) completed an online survey of validated measures of conversation orientation (i.e., the extent to which families openly communicate), SS, cancer openness, avoidance, caregiver burden, clinical communication skills, and quality of clinical interactions (QCI).ResultsConversation orientation had significant indirect effects on caregiver burden, mediated by SS (β = −0.11, p < 0.001), as well as cancer openness and avoidance (β = −0.07, p < 0.001). Conversation orientation also had significant indirect effects on caregivers' communication skills with a parent's clinician, mediated by avoidance (β = 0.08, p < 0.01) and SS (β = 0.06, p < 0.001). Finally, conversation orientation had significant indirect effects on caregivers' QCI mediated by avoidance (β = 0.71, p < 0.05).ConclusionsAdult child caregivers whose families communicate more openly exhibit less caregiver burden and report better clinical interaction skills and perceived quality of the clinical interaction. Avoidance emerged as a key mediating factor. Caregivers from less open communication environments may benefit from interventions that help them navigate challenging but critical caregiving conversations.
The impact of cancer on the mental health of patients parenting minor children: A systematic review of quantitative evidence
Authors: Johannsen Lene , Brandt Maja , Frerichs Wiebke , Inhestern Laura , Bergelt Corinna 
Published: February 2022

AbstractObjectiveTo provide an overview of quantitative data on the impact of cancer on the mental health of patients parenting minor children. We focused on mental health outcomes, their levels and prevalence, and applied measurement tools.MethodsMEDLINE, CINAHL, PsycInfo and Web of Science were searched up to March 2021. We included quantitative studies, published in a peer‐reviewed journal and reporting outcomes on the mental health (e.g., depression, anxiety) of cancer patients parenting minor children (≤ 21 years). Study quality was assessed based on the National Institute for Health assessment tool for observational studies. This study is registered on PROSPERO (CRD42019141954).ResultsA total of 54 articles based on 36 different studies were included in this systematic review. Studies differ markedly regarding study and sample characteristics (e.g., outcome measures, sample size, parental health status). Depression and anxiety levels range from normal to abnormal, according to applied measurement tools. 7%–83% of parents with cancer have depression scores indicating probable depression and 19%–88% have anxiety scores indicating anxiety disorder.ConclusionsThis review reveals the dimension of mental burden affecting cancer patients parenting minor children. To identify, address and timely treat potentially arising mental health problems and support needs, affected parents should be closely monitored by healthcare professionals and referred to specialized support offers, if necessary. In the context of a comprehensive patient‐ and family‐oriented care, it is highly relevant to integrate mental health (including parental) issues routinely into oncological care by proactively asking for the patient's psychosocial situation and the family status.
Coefficient of Thermal Expansion Evolution during Ratchet Growth of PBX 9502 and Neat TATB
Authors: Woznick Caitlin S. , Graff Thompson Darla , Scott Sidney J. 
Published: February 2022

AbstractThe Plastic‐Bonded Explosive (PBX) 9502 is comprised of the insensitive high explosive TATB (triamino trinitrobenzine) crystals coated in FK‐800 polymer binder and isostatically pressed. The TATB crystals have a graphitic, plate‐like morphology and possess significant thermal and mechanical anisotropy. Compactions of neat TATB or TATB‐based composites (like PBX 9502) have been shown to have TATB crystals that are oriented during the pressing process giving rise to TATB texture and resulting in micro‐ and macro‐scale anisotropy of the compaction. Thermal cycling of the compactions results in irreversible volume expansion (or ratchet growth) likely by creating stress points on the microscale. However, the actual mechanism behind this expansion is not fully understood. Previous characterization of the ratchet growth phenomenon has focused on the magnitude of the irreversible strain as measured before and after a thermal cycle. In the work presented here, we analyze the evolving thermal expansion behavior during the ascending and descending temperature ramps and compare differences observed due to the presence/absence of binder in the compaction.
Androgen deprivation therapy for prostate cancer and the risk of thyroid diseases
Authors: Liu Jui‐Ming , Chen Yu‐Tang , Wu Chun‐Te , Hsu Wen‐Lin , Hsu Ren‐Jun 
Published: February 2022

AbstractBackgroundAndrogen deprivation therapy (ADT) is the major treatment for metastatic prostate cancer (PCa), but few studies have investigated the effects of ADT on thyroid diseases.MethodsThis population‐based, nationwide cohort study utilized the Taiwan National Health Insurance Research Database (NHIRD) with 17,192 PCa patients between 1997 and 2013. We used the Cox proportional hazards models and propensity score‐matched analysis to analyze the association between ADT and the development of thyroid diseases.ResultsA total of 17,192 newly diagnosed men with PCa were selected from the NHIRD. There were 6200 ADT users and 6200 non‐ADT users after 1:1 propensity score matching. There was a significantly decreased risk of thyroid diseases among ADT users compared with non‐ADT users (adjusted hazard ratio (aHR): 0.79, 95% confidence interval (CI): 0.65–0.95, p < 0.001). Further analysis showed a significantly decreased risk of thyroid diseases with increasing ADT duration (p < 0.001).ConclusionsThe result showed that ADT use in men with PCa was associated with a decreased risk of thyroid disease development.
Nonsteroidal anti‐inflammatory drugs in acute viral respiratory tract infections: An updated systematic review
Authors: Azh Nima , Barzkar Farzaneh , Motamed‐Gorji Nogol , Pourvali‐Talatappeh Parmida , Moradi Yousef , Vesal Azad Roya , Ranjbar Mitra , Baradaran Hamid Reza 
Published: February 2022

AbstractIn this systematic review, we aimed to assess the efficacy and safety of nonsteroidal anti‐inflammatory drugs (NSAIDs) in treating respiratory tract infections in adults and children. PubMed, Scopus, Web of Science, Cochrane, and Embase databases were searched. A total of 34 randomized clinical trials were included in this systematic review. We assessed the risk of bias of all included studies using the Cochrane tool for risk of bias assessment. The evidence on ibuprofen, naproxen, aspirin, diclofenac, and other NSAIDs were rated for degree of uncertainty for each of the study outcomes and summarized using the grading of recommendations assessment, development, and evaluation (GRADE) approach. Our findings suggest that high‐quality evidence supports the use of NSAIDs to reduce fever in both adults and children. However, the evidence was uncertain for the use of NSAIDs to reduce cough. Most studies showed that NSAIDs significantly relieved sore throat. The evidence for mortality and oxygenation is limited. Regarding the adverse events, gastrointestinal discomfort was more frequently reported in children. For adults, our overall certainty in effect estimates was low and the increase in gastrointestinal adverse events was not clinically significant. In conclusion, NSAIDs seem to be beneficial in the outpatient management of fever and sore throat in adults and children. Although the evidence does not support their use to decrease mortality nor improve oxygenation in inpatient settings, the use of NSAIDs did not increase the rate of death or the need for ventilation in patients with respiratory tract infections. Further studies with a robust methodology and larger sample sizes are recommended.
Spatial–temporal distribution of Dalbulus maidis (Hemiptera: Cicadellidae) and factors affecting its abundance in Brazil corn
Authors: Foresti Josemar , Pereira Renata R , Santana Paulo A , das Neves Taline NC , da Silva Paulo R , Rosseto Jaédino , Novais Istchuk Ademar , Ishizuka Tamylin K , Harter Wagner , Schwertner Matheus H , Picanço Marcelo C 
Published: February 2022

AbstractBACKGROUNDSince the last decade, Dalbulus maidis has become the primary pest in cornfields, particularly due to its ability to transmit plant pathogens. Dalbulus maidis is the main vector of the corn stunt spiroplasma and maize bushy stunt phytoplasma. However, there is little information available on this pest. Understanding its spatial dynamics may allow us to determine how its infestations begin and to identify its colonization patterns, dispersal, and the role of landscape structure on D. maidis dynamics. Thus, this study aimed to investigate within‐field spatial distribution and the factors associated with D. maidis abundance in five commercial fields.RESULTSIn all fields, higher infestations occurred at the boundaries of the central pivot, showing a clear edge‐biased distribution. Ranges varied from 100.4 to 611.8 m, and our models' overall fit indicated strong to moderate spatial dependency. Additionally, correlation analyses indicated a positive effect of air temperature on the population of D. maidis. Conversely, rainfall negatively affected D. maidis.CONCLUSIONThis study provides essential guidance for improving D. maidis integrated pest management at regional and local scales. Based on its high dispersal ability, our study suggests the need for a legislative or regulatory method of control for D. maidis, especially in regions where corn has more than one growing season. © 2022 Society of Chemical Industry.
The impact of a preparatory science of learning intervention in secondary schools contexts in Australia
Authors: Byers Terry , Leighton Vicky , Leggett Jack , Krzensk Alex , Adamson Rebecca , Pollock Christopher , MacMahon Stephanie 
Published: February 2022

AbstractIt is well documented that students of all ages tend to rely on inefficient study strategies. In a departure from the accustomed reactive strategy‐training approach found in university settings, this study took a novel approach focusing on students at an earlier stage in their education. The aim was to evaluate the efficacy of early preparatory and applied instructional training interventions on secondary school‐age student learner behaviours (metacognition and self‐regulation) and study strategies (knowledge of, belief in and commitment in use) in their schooling contexts. It applied a single‐subject research design (SSRD) through a repeated measures approach in two Australian secondary schools, aided by a partnership with the University of Queensland. The study unpacked the impact, barriers and challenges of a preparatory study strategy training and instruction methodology. When the instruction focused on improving students’ knowledge of effective strategies, many appeared ambivalent with little change. However, when the study strategy training was integrated into subject curricula and assessments, this approach significantly increased students’ knowledge about them, belief in their efficacy and commitment to using them. These altered strategy preferences and use correlated with changes to learner behaviours associated with metacognitive knowledge, self‐efficacy and self‐regulation. Furthermore, teachers coached in integrating, applying and teaching the strategies reported similar increases in their knowledge, belief, and commitment to their use to suit their subjects’ curricular and assessment requirements. These initial findings highlight the ingredients to effectively instruct secondary students to translate the science of learning into their study plans.
Optimized data rate allocation for dynamic sensor fusion over resource constrained communication networks
Authors: Jung Hyunho , Pedram Ali Reza , Cuvelier Travis C. , Tanaka Takashi 
Published: February 2022

AbstractThis article presents a new method to solve a dynamic sensor fusion problem. We consider a large number of remote sensors which measure a common Gauss–Markov process. Each sensor encodes and transmits its measurement to a data fusion center through a resource restricted communication network. The communication cost incurred by a given sensor is quantified as the expected bitrate from the sensor to the fusion center. We propose an approach that attempts to minimize a weighted sum of these communication costs subject to a constraint on the state estimation error at the fusion center. We formulate the problem as a difference‐of‐convex program and apply the convex‐concave procedure (CCP) to obtain a heuristic solution. We consider a 1D heat transfer model and a model for 2D target tracking by a drone swarm for numerical studies. Through these simulations, we observe that our proposed approach has a tendency to assign zero data rate to unnecessary sensors indicating that our approach is sparsity‐promoting, and an effective sensor selection heuristic.
A fast manhattan frame estimation method based on normal vectors
Authors: Zhang Yutong , Ding Yan , Song Jianmei , Li Jiaxin , Wei Hua‐Liang 
Published: February 2022

AbstractIn most human made scenes, such as high‐rise urban city or indoor environment, the surface normal vectors or direction vectors are concentrated in three orthogonal principal directions. The scene of such a pattern is called Manhattan World (MW), and the coordinate frame formed by the three principal directions is called Manhattan Frame (MF). MF estimation methods have been applied to many different fields, such as scene reconstruction, Visual based Simultaneous Localization And Mapping (V‐SLAM) and camera calibration. In this paper, we propose a novel MF estimation method based on a set of normal vectors. A cost function of normal vectors and MF axes is introduced based on the trigonometric function. For computational purpose, the cost function is significantly simplified by making use of vector dot and cross products, and the reduced cost function only involves 14 scalar parameters that need to be computed with O(n) complexity. The experimental results show that the proposed MF estimation method has excellent real‐time performance and gives high accuracy on both the virtual and real‐world benchmark datasets of different sizes.
Communication frames and beneficiary engagement in corporate social initiatives: Evidence from a randomized controlled trial in France
Authors: Durand Rodolphe , Huysentruyt Marieke 
Published: February 2022

AbstractResearch SummaryThis article asks how distinct communication frames used by corporate social initiatives (CSIs) affect beneficiary engagement, specifically their reach vis‐à‐vis disadvantaged groups. Through a unique randomized field experiment in France, we assess the effectiveness of a series of communication frames on beneficiaries' decisions to enroll and use the social goods provided. Our results show that empathy‐ and simplicity‐oriented frames significantly increase program enrollment and utilization rates relative to other strategies, notably the widely used charity frame. We find that none of the tested communication frames raised take‐up by nonnative French beneficiaries, and only the empathy frame augmented the response of the very poor. Our work opens new research directions for strategic management studies on CSIs, communication frames, inclusion and social outcomes.Managerial SummaryMany corporate social initiatives (CSIs) launch large information campaigns to raise awareness about the social goods they provide. Findings from a field experiment reveal that the communication frames that CSIs deploy matters. Communication that expresses empathy (how the CSI understands and cares about its target beneficiaries) or presents simple information (what the CSI does) is far more effective at raising take‐up than communication frames that emphasize what for (why) and the charitable identity (who) about the CSI. However, results also reveal that foreigners and the economically most disadvantaged beneficiaries responded the least to these communication frames. This suggests that more is needed to effectively raise take‐up by these subgroups. Our work speaks to strategy researchers and practitioners interested in CSIs, communication frames, and social inclusion.
Progress of GaN‐Based Optoelectronic Devices Integrated with Optical Resonances
Authors: Zhao Lixia , Liu Chang , Wang Kaiyou 
Published: February 2022

AbstractBeing direct wide bandgap, III‐nitride (III‐N) semiconductors have many applications in optoelectronics, including light‐emitting diodes, lasers, detectors, photocatalysis, etc. Incorporation of III‐N semiconductors with high‐efficiency optical resonances including surface plasmons, distributed Bragg reflectors and micro cavities, has attracted considerable interests for upgrading their performance, which can not only reveal the new coupling mechanisms between optical resonances and quasiparticles, but also unveil the shield of novel optoelectronic devices with superior performances. In this review, the content covers the recent progress of GaN‐based optoelectronic devices integrated with plasmonics and/or micro resonators, including the LEDs, photodetectors, solar cells, and light photocatalysis. The authors aim to provide an inspiring insight of recent remarkable progress and breakthroughs, as well as a promising prospect for the future highly‐integrated, high speed, and efficient GaN‐based optoelectronic devices.