bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maxillary sinus floor augmentation comparing bovine versus porcine bone xenografts mixed with autogenous bone graft. A split‐mouth randomized controlled trial
Authors: Galindo‐Moreno Pablo , Abril‐García Dario , Carrillo‐Galvez Ana Belen , Zurita Federico , Martín‐Morales Natividad , O’Valle Francisco , Padial‐Molina Miguel 
Published: February 2022

AbstractAimTo compare the effectiveness of two xenografts for maxillary sinus floor augmentation in terms of clinical, radiographical, histologic, and molecular outcomes.Materials and methodsA split‐mouth randomized clinical trial was conducted at the University of Granada. Ten consecutive patients in need of bilateral two‐staged maxillary sinus floor augmentation were included. Each patient received both biomaterials (porcine bone mineral and anorganic bovine bone), which were randomly assigned for bilateral sinus augmentation. The maxillary autogenous bone scraped from the sinus access window was mixed with each xenograft at a 20:80 ratio. After a healing period of 6 months, bone biopsies were collected with a trephine during the implant placement in the regenerated area. Histologic, histomorphometrical, immunohistochemical, and molecular outcomes were analyzed. Clinical and radiographical data throughout the treatment phases were also evaluated.ResultsThe resulting anatomic features were similar between both groups. After six months of graft consolidation, the graft resorption rates were similar between both biomaterials. The histologic, histomorphometrical, and immunohistochemical results showed no statistical differences between groups.ConclusionAnorganic bovine bone and porcine bone mineral combined with maxillary autogenous cortical bone show similar biologic and radiologic features in terms of biomaterial resorption, osteoconduction, and osteogenesis when used for maxillary sinus floor augmentation.
High cutaneous amphiregulin expression predicts fatal acute graft‐versus‐host disease
Authors: Schultz Brittney , Miller Daniel D. , DeFor Todd , Blazar Bruce R. , Panoskaltsis‐Mortari Angela , Betts Brian C. , MacMillan Margaret L. , Weisdorf Daniel J. , Holtan Shernan G. 
Published: February 2022

AbstractBackgroundAmphiregulin (AREG) is increased in circulation in acute graft‐versus‐host disease (aGVHD) and is associated with poor steroid response and lower survival. The expression of AREG in aGVHD target organs and its association with clinical outcomes are unknown.MethodsWe performed AREG immunohistochemical staining on skin specimens from 67 patients with aGVHD between the years 2010 and 2015. Two blinded reviewers assessed AREG expression and scored specimens with a semiquantitative scale ranging from 0 (absent) to 4 (most intense).ResultsMedian AREG score of aGVHD cases was 3. Sixteen of 67 (23.9%) aGVHD cases had an AREG >3. High skin AREG expression (>3 vs. ≤3) was associated with increased overall clinical grade of aGVHD (52.9% vs. 33.4% clinical grade III‐IV, p = 0.02), reduced 3‐year overall survival (OS; 13% vs. 61%, p < 0.01), and increased 3‐year non‐relapse mortality (NRM; 56% vs. 20%, p = 0.05).ConclusionHigh skin AREG immunohistochemical expression is associated with high clinical grade aGVHD, poor OS, and increased NRM.
Continous somatosensory evoked potentials and brain injury in neonatal hypoxic‐ischaemic encephalopathy treated with hypothermia
Authors: Lori Silvia , Bertini Giovanna , Bastianelli Maria Elena , Gabbanini Simonetta , Cossu Cesarina , Mortilla Marzia , Dani Carlo 
Published: February 2022

AimTo explore whether continuous somatosensory evoked potentials (SEPs) monitoring and video electroencephalograms (VEEG) accurately predict lesions observed on brain magnetic resonance imaging (MRI) in neonates with hypoxic‐ischaemic encephalopathy (HIE) receiving therapeutic hypothermia.MethodThis prospective study included 31 neonates (16 males, 15 females; mean [SD] gestational age 39 weeks [1.67]) who received therapeutic hypothermia for HIE. Therapeutic hypothermia was provided for 72 hours, with a target temperature of 33.0°C to 34.0°C and this was followed by a rewarming rate of approximately 0.5°C per hour, up to 36.5°C. SEPs and VEEG were evaluated simultaneously and continuously for 1 hour under normothermic conditions. MRI was carried out at a mean (SD) age of 6 (2) days.ResultsOur results showed a statistically significant correlation between continuous SEP and MRI scores (r=0.37, p=0.03), but not between the VEEG and MRI scores (r=0.30, p=0.09). Receiver operating characteristic analysis confirmed that continuous SEPs were highly specific and sensitive at predicting MRI abnormalities, whereas the VEEG had high specificity but low sensitivity.InterpretationContinuous monitoring of SEPs could provide early and important prognostic information in neonates with HIE.What this paper adds

Early continuous somatosensory evoked potential (SEP) monitoring is correlated with hypoxic‐ischaemic encephalopathy (HIE) lesions.

Video electroencephalograms (VEEGs) are associated with lesions diagnosed after magnetic resonance imaging.

Both showed high specificity, but VEEGs did not show high sensitivity.

Continuously monitoring SEPs provides important information about HIE.
Association between preoperative diastolic dysfunction and early allograft dysfunction after orthotopic liver transplantation: An observational study
Authors: Vetrugno Luigi , Cherchi Vittorio , Zanini Victor , Cotrozzi Silvia , Ventin Marco , Terrosu Giovanni , Baccarani Umberto , Bove Tiziana 
Published: February 2022

AbstractObjectives: To investigate the association between the grade of diastolic dysfunction (DD) and the occurrence of early allograft dysfunction (EAD) in liver transplant patients following the new 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging (ASE/EACVI) guidelines.Methods: From January 2015 to December 2019, we retrospectively analyzed 83 patients who underwent orthotopic liver transplantation (OLTx) and their susceptibility to develop EAD according to the grade of preoperative DD. EAD was defined according to the criteria proposed by Olfhoff et al.; DD was defined with four parameters: E/A, e/e’, Left Atrium volume, and Tricuspid Regurgitation velocity.Results: According to the ASE/EACVI guidelines grade II DD was detected in 20 patients (24.1%) undergoing OLTx. A statistically significant association was found between grade II DD and the occurrence of EAD (p‐value < 0.003). The Kaplan‐Meier analysis failed to find any significant difference between the survival probability, nevertheless at the end of a 90‐day follow‐up period, mortality showed a different trend in classes with more severe diastolic dysfunction.Conclusion: According to the ASE/EACVI guidelines from 2016, patients with grade II DD seem to have a higher propensity to develop early allograft dysfunction EAD after OLTx. Our study advises a need for an urgent prospective multicenter study to elucidate the long‐term outcomes of liver transplants patients with diastolic dysfunction.
A comprehensive review of adverse events to drugs used in COVID‐19 patients: Recent clinical evidence
Authors: Ferreira‐da‐Silva Renato , Ribeiro‐Vaz Inês , Morato Manuela , Junqueira Polónia Jorge 
Published: February 2022

AbstractBackgroundSince the breakthrough of the pandemic, several drugs have been used to treat COVID‐19 patients. This review aims to gather information on adverse events (AE) related to most drugs used in this context.MethodsWe performed a literature search to find articles that contained information about AE in COVID‐19 patients. We analysed and reviewed the most relevant studies in the Medline (via PubMed), Scopus and Web of Science. The most frequent AE identified were grouped in our qualitative analysis by System Organ Class (SOC), the highest level of the MedDRA medical terminology for each of the drugs studied.ResultsThe most frequent SOCs among the included drugs are investigations (n = 7 drugs); skin and subcutaneous tissue disorders (n = 5 drugs); and nervous system disorders, infections and infestations, gastrointestinal disorders, hepatobiliary disorders, and metabolism and nutrition disorders (n = 4 drugs). Other SOCs also emerged, such as general disorders and administration site conditions, renal and urinary disorders, vascular disorders and cardiac disorders (n = 3 drugs). Less frequent SOC were eye disorders, respiratory, thoracic and mediastinal disorders, musculoskeletal and connective tissue disorders, and immune system disorders (n = 2 drugs). Psychiatric disorders, and injury, poisoning and procedural complications were also reported (n = 1 drug).ConclusionsSome SOCs seem to be more frequent than others among the COVID‐19 drugs included, although neither of the studies included reported causality analysis. For that purpose, further clinical studies with robust methodologies, as randomised controlled trials, should be designed and performed.
Time dependence of hydraulic parameters estimation from transient analysis of mini disc infiltrometer measurements
Authors: Naik Aparimita Priyadarshini , Pekkat Sreeja 
Published: February 2022

AbstractThe transient analysis of mini disc infiltrometer (MDI) measurements is an established method for characterising near‐surface hydraulic characteristics of soils. The reliability of hydraulic characteristics obtained from transient analysis depends on the (1) adequacy of model, (2) adequacy of data, (3) measurement time and (4) measurement footprint. The measurement time dependence recommendations are reported only for a few soil textures, initially wet samples and tension infiltrometer (TI) with a higher measurement footprint than the MDI. This study investigated the adequacy of infiltration data (using cumulative linearization [CL] and differentiated linearization [DL]) and measurement time influence on the hydraulic parameters determined from the transient analysis of MDI measurements for six soil textures. The objective of the study is to identify suitable MDI measurement durations for different soil textures for the initially dry state, considering both adequacy of data and time fractionation (measurement time influence). The data adequacy time obtained from the DL (TDL) was found to be 0.8 times less than the value obtained from CL (TCL). The marginal difference in TDL and TCL had a significant influence on the determination of infiltration equation coefficient C1 and negligible influence on coefficient C2. The time fractionation procedure adopted for identifying adequate MDI measurement time (Tm) was found to be comparable based on sorptivity (S0) and hydraulic conductivity (K0). The average Tm was also comparable with TDL and TCL with a strong positive correlation. The C2 values obtained based on Tm, TDL, and TCL were in better agreement than the corresponding C1 values. The adequate MDI measurement times identified by considering Tm, TDL, and TCL were texture dependent, ranging from 45 min for silt to 120 min for silt loam and silty clay loam. For loamy sand, it was 50 min; for sand, it was 70 min, followed by 60 min for loam.
Is there a correlation between MOG‐associated disorder and SARS‐CoV‐2 infection?
Authors: Mariotto Sara , Carta Sara , Dinoto Alessandro , Lippi Giuseppe , Salvagno Gian Luca , Masin Laura , Alberti Daniela , Marignier Romain , Ferrari Sergio 
Published: February 2022

AbstractBackground and purposeAnti‐myelin oligodendrocyte glycoprotein antibodies (MOG‐Abs) distinguish a group of inflammatory disorders which can be preceded by specific or non‐specific infections. A few single cases have been reported in association with SARS‐CoV‐2 infection, but a specific study on the correlation between COVID‐19 and myelin oligodendrocyte glycoprotein (MOG)‐associated disorder (MOGAD) has not yet been performed. The aim of this study was to determine the impact of the pandemic on this condition.MethodsWe analysed SARS‐CoV‐2 serology in patients newly diagnosed with MOGAD (1 August 2020 to 31 May 2021). MOG‐Ab‐seronegative age‐ and time‐matched subjects were used as controls. SARS‐CoV‐2 immunoglobulin G (IgG) levels were analysed using an anti‐SARS‐CoV‐2 US Food and Drug Administration‐approved ELISA assay and confirmed with a trimeric anti‐SARS‐CoV‐2 S1/S2 IgG immunochemiluminescent test, concomitantly assaying the anti‐receptor binding domain (RBD) of spike protein IgG and anti‐RBD total Ig. We actually compared the number of cases referred in each of the last 3 years.ResultsPresence of SARS‐CoV‐2 IgG antibodies was more common (12/30, 40%) in MOGAD patients than in controls (6/30, 20%), although the difference was not significant (p = 0.16; odds ratio 2.67, 95% confidence interval 0.85–9.17). The most common clinical presentations of MOGAD SARS‐CoV‐2‐seropositive patients included optic neuritis (n = 6) and myelitis (n = 3). The number of diagnosed cases increased over the last 3 years, in particular, when including cases referred to us before the COVID‐19 pandemic, in the initial phase of the first wave and in the late phase of the second wave (n = 9, rate 10.6% in 2019; n = 13, rate 12.3% in 2020; n = 15, rate 14.7% in 2021).ConclusionOur findings provide preliminary data on SARS‐CoV‐2 as a potential trigger of MOGAD.
Autotrophs are important contributors to benthic macroinvertebrate food webs in two tropical first‐order forest streams
Authors: Cortés‐Guzmán Daniela , Alcocer Javier , Planas Dolors 
Published: February 2022

Abstract

In tropical first‐order streams, the availability of basal resources changes according to tropical seasonality, i.e., dry and rainy seasons, with consequences for the food web structure. However, the seasonal variation in autotrophic and detrital pathways remains unclear. In this study, we aimed to establish whether the dominant pathway of the benthic macroinvertebrate food web in two tropical first‐order streams in the Lacandona rainforest, Mexico, relies on autotrophic or detrital food resources.

We evaluated the assimilation of autotrophic and detrital food resources through carbon and nitrogen stable isotope (δ13C and δ15N) analysis. We included the biomass of the macroinvertebrates sustained by the autotrophic and detrital pathways and the food web structure—trophic position, size structure, and degree of omnivory.

The biomass sustained by the detrital pathway remained similar throughout the year in both streams. In contrast, the biomass sustained by the autotrophic pathway was higher in the dry season than in the rainy season. The benthic macroinvertebrate food web had four levels, a poorly developed size structure, and an important degree of omnivory in both streams and in both seasons. It is likely that omnivory was a response to high resource variability and a strategy to reduce intraguild competition.

Autotrophs had a relatively higher importance than detritus since a much lower algae biomass sustained an equal or higher macroinvertebrate biomass, particularly in the dry season when the biomass of autotrophs increased. Seasonality influenced the macroinvertebrate food web by modifying the food resource availability and transference to higher trophic levels. However, the high frequency of omnivory reduced the seasonal changes in the food web structure.

Our results suggest that the autotrophic pathway plays an important role in maintaining the benthic macroinvertebrate food web in tropical streams. The relative importance of autotrophs in the macroinvertebrate food web is associated with seasonality, the rainfall pattern, and its effect on the stream hydrology.
Remote schooling during a pandemic: Visibly Muslim mothering and the entanglement of personal and political
Authors: Özdemir Şeyma 
Published: February 2022

AbstractThis experimental double‐conscious autoethnography narrates my navigation of remote learning after the COVID‐19 outbreak between mid‐March and early June 2020 as an apparent Muslim mother at a public school in upstate New York. To this end, using handwritten notes in a daily journal, I first delineated the process of becoming a visibly Muslim mother, which started earlier and reached a head after moving to the United States in 2018. In this way, using an autoethnographic style based on my experience of remote learning as a Muslim mother, I will present a dialog with feminist insights to reiterate that personal experience and cultural experience are incapable of being disentangled, that personal experience matters, and that all experience, however personal or private, is structured in a broader political and historical context.
Aerobic exercise in patients with haemophilia: A systematic review on safety, feasibility and health effects
Authors: Tomschi Fabian , Ransmann Pia , Hilberg Thomas 
Published: February 2022

AbstractBackgroundHaemophilia is a congenital bleeding disorder going along with disease‐specific joint complications and general health implications attributed to the lack of daily movement. Recent guidelines recommend physical activity for people with haemophilia (PwH). Yet, aerobic exercise in PwH is little studied and seldomly prescribed by clinicans.AimThe aim of this systematic review is to investigate the safety, feasibility and health‐related efficiency of AE in PwH.MethodsA systematic literature search according to the PRISMA guidelines was conducted (PubMed, Web of Science). Inclusion criteria were defined using PICOS. Methodological quality was assessed via TESTEX.ResultsOut of 789 studies identified, seven studies (three randomized controlled, two controlled, two single‐group prospective trails) were included. The TESTEX mean score was 8.1 (±3.8). AE was realized as aquatic exercise, nordic walking, treadmill running, bicycle riding and swimming. Neither bleeding rates nor the factor amount increased and AE led to diverse health‐related improvements.ConclusionsLittle research has been conducted evaluating AE in PwH. Yet, AE can be considered as safe and feasible when being supervised by experts. However, disease‐specific recommendations for AE are difficult to provide. Therefore, experts can currently only back AE recommendations on experience and nonhaemophilia‐specific general guidelines.
Comparative evaluation of complete and partial pulpotomy in mature permanent teeth with symptomatic irreversible pulpitis: A randomized clinical trial
Authors: Ramani Ankita , Sangwan Pankaj , Tewari Sanjay , Duhan Jigyasa , Mittal Shweta , Kumar Vinay 
Published: February 2022

AbstractAimThe study aimed to compare the outcome of complete pulpotomy (CP) and partial pulpotomy (PP) techniques when utilised for the management of mature permanent teeth with carious pulpal exposure and symptomatic irreversible pulpitis (SIP).MethodologyThe study protocol was registered with ClinicalTrials.gov (NCT04397315). One hundred and six permanent mandibular molars with carious pulpal exposure and clinical diagnosis of SIP with periapical index ≤2, from patients aged between 18 and 40 years were randomly allocated in equal proportion to either CP or PP group. Allocated procedures were performed using standardised protocols. The allocated procedure was abandoned in cases where pulpal bleeding could not be controlled within 6 min using cotton pellets soaked in 3% sodium hypochlorite. MTA was used as a pulpotomy agent and teeth were restored using a base of glass ionomer followed by composite restoration. The pain was recorded by the patient preoperatively before administration of local anaesthesia and postoperatively every 24 h for 1 week using visual analogue scale. Success was analysed at 12 months based on clinical and radiographic examination. Mann–Whitney U test was used to compare age, pain scores and mean analgesic consumption between the groups. Categorical data were analysed using chi‐square test. Fisher's exact test was used to assess the clinical and radiographic success and incidence of pain. Kaplan–Meier analysis was used to assess the survival of teeth. A p‐value <.05 was considered as statistically significant.ResultsOne hundred and one patients were analysed at follow up. Higher success was observed in CP (89.8%) in comparison to PP group (80.8%), but the difference was non‐significant statistically (p = .202). Although no significant difference was observed in pain incidence between the groups at 24 h (p = .496), a significant difference in pain intensities was observed between groups at all the tested time intervals, with lower values reported in CP group (p < .05).ConclusionsBoth CP and PP resulted in favourable outcomes in the management of cariously exposed permanent teeth with signs indicative of SIP. Given the more conservative nature of PP, it may be attempted first before proceeding to CP in such cases.
Angiogenesis in patient‐derived xenografts of odontogenic myxoma
Authors: Souza Juliana Cristina de , Bastos Victor Coutinho , Pereira Núbia Braga , Dias Adriana Abalen Martins , Avelar Gleide Fernandes de , Gomez Ricardo Santiago , Gomes Carolina Cavaliéri 
Published: February 2022

AbstractPreviously, by employing 3D organotypic tissue culture and patient‐derived xenograft (PDX) model, oral myxoma response to a MAPK/MEK inhibitor was observed. Gross examination of the tumour fragments obtained after 55 days of PDX grafting revealed increased capsule vascularization. Microscopic analyses showed blood capillaries intermixed with myxoma cells, but the origin of these capillaries, from mice or humans, was not established. This study aimed to investigate whether the endothelial cells observed in the myxoma PDX model are derived from the mouse or from the primary human tumour. Immunohistochemistry was performed on five tumour fragments from the PDX of myxoma after 55 days of implantation in mice. Immunopositivity for antibodies against human (HLA‐ABC) and mouse (H2 Db/H2‐D1) major histocompatibility complex class I (MHCI) was assessed in the endothelial cells. The endothelial cells in the PDX fragments revealed a membrane staining for the human MHCI protein in the PDX tumour and adjacent connective tissue capsule, indicating that capillaries were derived from the human tumour fragment. Considering the probable human origin of the endothelial cells from capillary blood vessels in the myxoma PDX, we conclude that this PDX model is an interesting model to study myxoma angiogenesis.
COVID‐19 and threats to irregular migrants in Kuwait and the Gulf
Authors: Shah Nasra M. , Alkazi Lubna 
Published: February 2022

AbstractPrior to the COVID‐19 Pandemic, the Gulf region was home to ~29 million foreign residents, an estimated 20–40% of whom were residing there in an irregular status. Most of them had skilfully devised strategies to survive in this irregular situation, with friends and relatives acting as essential support networks. The COVID‐19 Pandemic suddenly disrupted this well‐established social order. This article outlines the lived experiences of 26 irregular migrants residing in Kuwait when the Pandemic occurred. Twelve of our interviewees were planning to leave in response to the amnesty declared on 1 April, while 14 were planning to stay or were uncertain. Network support continued to provide an essential element in enabling their survival. Intermediaries such as kafeels (sponsors) were often unavailable or unwilling to provide assistance. The health and welfare of irregular migrants require special policy attention since they now face an enhanced risk of being apprehended and deported.