bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clean energy technology pathways from research to commercialization: Policy and practice case studies
Authors: Engel-Cox Jill A. , Merrill Wyatt G. , Mapes Marie K. , McKenney Ben C. , Bouza Antonio M. , DeMeo Edgar , Hubbard Mary , Miller Eric L. , Tusing Richard , Walker Brian J. 
Published: November 2022

Clean energy research and development (R and D) leading to commercial technologies is vital to economic development, technology competitiveness, and reduced environmental impact. Over the past 30 years, such efforts have advanced technology performance and reduced cost by leveraging network effects and economies of scale. After demonstrating promise in applied R and D, successful clean energy and energy efficiency technologies are incorporated into an initial product sold by the private sector. Despite its importance, processes by which first commercialization occurs are difficult to generalize while capturing specific insights from practitioners in markets and technologies. This paper presents a policy-focused qualitative assessment of the first commercialization of four diverse energy technologies: thin film photovoltaics, wind turbine blades, dual-stage refrigeration evaporators, and fuel cells for material handling equipment. Each technology presents distinct value propositions, markets, and regulatory drivers. The case studies indicate three common characteristics of successful first commercialization for new energy technologies: 1) good fit between the technology, R&amp;D infrastructure, and public-private partnership models; 2) high degree of alignment of government regulations and R&amp;D priorities with market forces; and 3) compatibility between time scales required for R&amp;D, product development, and opportunities. These findings may inform energy investment decision-making, maximize benefits from R&amp;D, and advance the transition to a low-emission future.
Source water microorganism assessment in three cities in China: A comparative study
Authors: Liu Yang , Smith Charlotte D. , Li Hongxing , Wang Duochun 
Published: November 2022

Reservoirs, rivers and groundwater are the top three sources of drinking water supplies in China. As microbial contamination of drinking water is still a prominent water quality problem in rural areas, understanding the microbial quality of these sources is important to the public’s health and economic prosperity of communities. In this study, three types of source water samples were collected from three cities in China. Bacterial contamination indicators testing showed that: total coliforms (TCs) and potential E. coli were not detected in groundwater, but both were detected in river and reservoir water. Total bacteria (TB) of rivers and Res-Ⅰ (sampling site Ⅰ of reservoir water) were greater than 100 CFU/ml, while less than 100 CFU/ml from Res-Ⅱ (sampling site Ⅱ of reservoir water) and groundwater. Salmonella spp. were isolated from river water and no pathogenic microorganisms were isolated from the other two types of water sources by selective culture. Microbial communities testing by 16S rRNA gene amplicon sequencing indicated that, there were 14,114 operational taxonomic unit (OTU) of microbial abundance from all 30 samples, and most OTUs were only present in river water (15.17%), reservoir water (10.46%) or groundwater (43.91%), while 1540 OTUs (10.91%) were shared by all three types of water sources. There were significant differences in the microbial communities of the three types of source water (p &lt; 0.05). Based on the Ace, Chao, and Shannon-Weaver, and Simpson indexes, the species diversity of bacteria in groundwater was higher than in river water or reservoir water (p &lt; 0.05), with the reservoir water having the lowest diversity of bacteria. More than seven potential pathogenic bacteria were detected in 30 water samples, for example, E. coli, Staphylococcus aureus, Clostridioides difficile and Bacteroides fragilis were present in all three types of water sources, while other pathogenic bacteria occurred only in some of the water samples. Clostridium perfringens were detected in river water and groundwater. This study adds information on the microbial communities of various drinking water sources in rural China, which is valuable to water treatment and waterborne pathogen studies. In addition, this study supports the idea that 16S rRNA gene amplicon sequencing could be used as a supplementary tool for sources water quality monitoring.
Characterization of pregnancy outcome of women with an offspring with inborn errors of metabolism: A population-based study
Authors: Epstein Weiss Tali , Erez Offer , Hazan Itai , Babiev Amit-Shira , Staretz Chacham Orna 
Published: November 2022

Introduction:Inborn errors of metabolism (IEM) are scarce, and their diagnosis is often made after birth. This has led to the perception that most fetuses affected by these disorders do not become clinically apparent during pregnancy.Our aim was to determine the obstetrical characteristics of women with an offspring affected by IEM.Methods:This population-based retrospective cohort study included all women who delivered at the Soroka University Medical Center (SUMC) from 1988 to 2017 who met the inclusion criteria. Mothers who had an offspring with IEM were included in the study group, and those who had offsprings without IEM comprised the comparison group.Results:A total of 388,813 pregnancies were included in the study, and 184 of them were complicated by a fetus with IEM. The number of Bedouin women was higher in the IEM-affected infant group than in the comparison group (90.8%vs. 53.3%,p&lt; 0.001); women who had a fetus with IEM had a higher rate of polyhydramnios (7.1%vs. 3.2%,p= 0.005), HELLP syndrome (3.3%vs. 1.1%,p= 0.014), and preterm birth (20.7%vs. 10.1%,p&lt; 0.001); neonates with IEM had lower mean birth weight (p&lt; 0.001), lower Apgar scores at 1′ and 5′ minutes (p&lt; 0.001), and a higher rate of fetal growth restriction (FGR) (p&lt; 0.001), postpartum death &lt;28 days (p&lt; 0.001), and neonatal death (p&lt; 0.001) than those in the comparison group. Pregnancies with IEM fetuses were independently associated with preterm birth (OR 2.00; CI 1.4–3), polyhydramnios (OR 2.08; CI 1.17–3.71), and FGR (OR 2.24; CI 1.2–4.19). Each family of metabolic diseases is independently associated with specific pregnancy complications (i.e., mitochondrial diseases are associated with HELLP syndrome (OR 5.6; CI 1.8–17), and lysosomal storage disease are associated with nonimmune hydrops fetalis (OR 26.4; CI 3.39–206).Conclusion:This study reports for the first time, an independent association of IEM with specific complications of pregnancy. This observation has clinical implications, as the identification of specific pregnancy complications in a population at risk for IEM can assist in the prenatal diagnosis of an affected fetus.
Retinoids in cancer chemoprevention and therapy: Meta-analysis of randomized controlled trials
Authors: Chen Shuting , Hu Qinchao , Tao Xiaoan , Xia Juan , Wu Tong , Cheng Bin , Wang Juan 
Published: November 2022

Retinoids, natural and synthetic derivatives of vitamin A, have many regulatory functions in human body, including regulating cellular proliferation, differentiation, apoptosis. Moreover, retinoids have been used successfully for the treatment of certain malignancies, especially acute promyelocytic leukemia (APL) in adults and neuroblastoma in children. However, retinoids have not yet been translated into effective systemic treatments for most solid cancers. Some recent studies have shown that retinoids promote tumorigenesis. Therefore, we performed this meta-analysis to systematically evaluate the efficacy of retinoids in the chemoprevention and treatment of cancers. We performed literature search of several electronic databases, including PubMed, Embase and Cochrane Library from 2000 January to 2021 November. Various outcomes were applied to investigate the potential of retinoids for prevention and treatment of cancers. The primary outcomes in this study were disease recurrence and clinical response. The secondary outcomes included overall survival (OS), cancer development, disease progression and event-free survival. We identified 39 randomized controlled trials with 15,627 patients in this study. Our results showed that lower recurrence rate and better clinical response were obtained in retinoids treated patients with cancer or premalignancy as compared with control. The differences were statistically significant (RR = 0.85, 95% CI = 0.74–0.96, p = 0.01; RR = 1.24, 95% CI = 1.03–1.49, p = 0.02, respectively). Retinoids treatment was not associated with improvement in overall survival, cancer development, disease progression or event-free survival. Subgroup analysis conducted based on cancer type showed that patients benefited from retinoids treatment in APL, renal cell carcinoma, hepatocellular carcinoma, lung cancer, Kaposi sarcoma, and complete hydatidiform mole. No significant therapeutic effect was noted in head and neck cancer, acute myeloid leukemia (AML), melanoma, breast cancer, bladder cancer, cervical intraepithelial neoplasia (CIN) or cervical carcinoma. Subgroup analysis based on tumor classification demonstrated that retinoids group obtained a lower recurrence rate and better clinical response than control group in solid cancers. In conclusion, clinical application of retinoids was associated with reduction in disease recurrence and improvement in clinical response, illustrating that retinoids play a key role in cancer prevention and therapy. Further research is needed to broaden the utility of retinoids in other types of cancers.Systematic Review Registration: PROSPERO, identifier CRD42022296706.
Cold stimuli, hot topic: An updated review on the biological activity of menthol in relation to inflammation
Authors: Cheng Haojin , An Xuemei 
Published: November 2022

BackgroundRising incidence of inflammation-related diseases is an increasing concern nowadays. However, while menthol is a wildly-used and efficacious complementary medicine, its pharmacological mechanism still remains uncertain. Superimposed upon that, the aim of this review is to summarize the contemporary evidence of menthol’s anti-inflammatory activity.MethodsUsing the pharmacopeias and electronic databases, including Web of Science, PubMed, and CNKI, this study analyzed the relevant research articles and review articles from 2002 to 2022 and concluded those results and conjectures to finish this article.ResultsThe decrease in pro-inflammatory cytokines and related inflammatory markers, as well as associated pathway activation, was found to play the greatest role in the protective effects of menthol against inflammatory damage or association with protection against chronic inflammation.ConclusionThis review mainly concludes the progress in menthol’s anti-inflammatory activity. Further studies are needed to establish relationships between the mechanisms of action and to clarify the clinical relevance of any anti-inflammatory effects.
A recombinant Artemisia vulgaris pollen adjuvanted Art v 1 protein-based vaccine treats allergic rhinitis and bronchial asthma using pre- and co-seasonal ultrashort immunotherapy regimens in sensitized mice
Authors: Babayeva Meruert , Tabynov Kairat , Nurpeisov Tair , Fomin Gleb , Renukaradhya Gourapura J. , Petrovsky Nikolai , Tabynov Kaissar 
Published: November 2022

Allergic rhinitis is an important risk factor for bronchial asthma. Allergen-specific immunotherapy (ASIT) is the gold standard for treatment of allergic rhinitis, conjunctivitis, and asthma. A disadvantage of current ASIT methods is the length of therapy which requires numerous allergen administrations. The success of ASIT is determined by its schedule, which, depending on the vaccine and type of allergy, can be pre-seasonal (before the allergy season begins), combined pre/co-seasonal (during the allergy season) etc. The aim of the present study was to evaluate a vaccine based on recombinant Artemisia vulgaris pollen major Art v 1 protein formulated with ISA-51 adjuvant for therapy of allergic rhinitis and bronchial asthma in Artemisia-sensitized mice in an ultrashort (4 subcutaneous injections at weekly intervals) pre- and co-seasonal ASIT regimen.To simulate co-seasonal ASIT in mice, mice were regularly challenged with intranasal and nebulized Artemisia vulgaris pollen extract at the same time as receiving subcutaneous ASIT. For comparison, we used a previous Art v 1 protein vaccine formulated with SWE adjuvant, which in this study was modified by adding CpG oligonucleotide (Th1-biasing synthetic toll-like receptor 9 agonist), and a commercial vaccine containing a modified Artemisia vulgaris extract with aluminum hydroxide adjuvant. The therapeutic potential of Art v 1 based vaccine formulations with different ASIT regimens was evaluated in high and low (10 times lower) dose regimens.The ISA-51-adjuvanted vaccine formulations were the only ones among those studied in the ultrashort pre- and co-seasonal ASIT regimens to provide significant reduction in both signs of allergic rhinitis and bronchial asthma in sensitized mice (vs. positive control). In the ISA-51 adjuvanted group, immune response polarization toward Th1/Treg was observed in pre-seasonal ASIT, as reflected in a significant decrease in the serum level of total and Art v 1-specific IgE and increased ratios of allergen-specific IgG2a/IgG1 and IFN-γ/IL-4. The high dose SWE-CpG-adjuvanted vaccine had similar efficacy to the ISA-51 adjuvanted groups whereas the commercial vaccine showed significantly less effectiveness.The findings support further preclinical safety studies of the Art v 1-based vaccine formulated with ISA-51 adjuvant.
Comparison of macroalgae meadows in warm Atlantic versus cold Arctic regimes in the high-Arctic Svalbard
Authors: Wiktor Józef M. , Tatarek Agnieszka , Kruss Aleksandra , Singh Rakesh Kumar , Wiktor Józef M. , Søreide Janne E. 
Published: November 2022

A warmer Arctic with less sea ice will likely improve macroalgae growth conditions, but observational data to support this hypothesis are scarce. In this study, we combined hydroacoustic and video inspections to compare the depth of growth, density and thickness of macroalgae (&gt;10 cm) meadows in two contrasting climate regimes in Svalbard 1) the warm, ice free, Atlantic influenced West Spitsbergen and 2) the cold, Arctic and seasonal ice covered East Spitsbergen. Both places had similar insolation and comparable turbidity levels. Macroalgae communities at both places were similar and were formed mainly by common north Atlantic kelp species:Saccharina latissima, Alaria esculenta, Laminaria digitataandL. hyperborea. However, the density of the bottom coverage and thalli condition were strikingly different between the two sites. Algae at the warmer site were intact and fully developed and occupied most of the available hard substrate. At the colder site, only patchy macroalgae canopies were found and most thallies were physically damaged and trimmed at a uniform height due to physical ice scouring. These differences in macroalgal density and thalli condition were only found at depths down to 5 m. Deeper, no distinct differences were observed between the warm and cold sites. Sea urchins were only observed at the warm site, but in few numbers with no visible negative top-down control on macroalgae growth.
Remediation of water contaminated with polycyclic aromatic hydrocarbons using liquid phase plasma: Influence of electrical discharge condition
Authors: Kim Ui-Jun , Saito Nagahiro , Lee Seung-Hyo 
Published: November 2022

Although the number of vessels with exhaust gas cleaning systems (EGCSs or scrubbers) has sharply increased to comply with strengthened regulations for marine environment, secondary pollutions are caused by discharged polycyclic aromatic hydrocarbons (PAHs) from scrubber effluent. Here, liquid-phase plasma (LPP) is employed to remediate water contaminated with PAHs. The increased frequency and pulse width enhanced the degradation efficiency, and 93.3, 90.7, 86.0, and 85.4% for naphthalene (Nap), acenaphthene (Ace), fluorene (Flu), and phenanthrene (Phe), respectively, are degraded at a frequency of 30 kHz and pulse width of 3 μs in 10 min. Considering physical condition of the plasma, long pulse width accelerated electrons, leading to increased generation of active species from intensified collision between electrons and surrounding molecules. Conversely, high frequency decelerated electrons due to the excessive changes in the polarity. However, the increased number of plasma discharges results in the generation of numerous active species. Generations of •OH and O radicals are confirmed by optical emission spectrometry and electron paramagnetic resonance. In addition, changes in functional groups which are corresponding to hydroxyl and oxygen groups are identified by Fourier transform infrared spectroscopy. Total PAHs in real scrubber are reduced from 1.1 to 0.4 μgL-1 with degradation efficiency of 63.6% after 10 min of LPP treatment. This study suggests LPP can be a promising method to protect diverse aqueous environments and provides optimal electrical discharge condition for degradation of organic pollutants.
Development of a core outcome set in the clinical trials of traditional Chinese medicine for diabetic foot: A study protocol
Authors: Dai Xin Yue , Zi Ming Jie , Liu Chun Xiang , Wang Yi Ming , Gao Rui 
Published: November 2022

BackgroundDiabetic Foot (DF) is one of the most common complications of diabetes, and it is characterized by high morbidity, disability, lethality and low cure rate. Traditional Chinese medicine treatment has certain characteristics and advantages in diabetic foot. Due to selective reporting bias and heterogeneity of research results, on the one hand, relevant clinical studies are of low quality and poor practicability, and on the other hand, similar studies cannot be included in meta-analysis to form high-quality evidence-based evidence and evaluate the value of studies. Therefore, the development of a core set of outcomes (COS-TCM-DF) for traditional Chinese medicine for the treatment of diabetic foot is an important way to address these issues.MethodsThe COS-TCM-DF project will refer to the developed COS methodology and the steps are divided into four stages: (1) a scoping review and analysis of enrolled research protocols to collect and analyze all existing outcomes that have been used in trials on the prevention or treatment of diabetic foot with Chinese Medicine; (2) qualitative interviews with Diabetic foot patient and attendants to Collect additional outcomes related to them; (3) Gather opinionest and obtain initial consensus from key stakeholders, including patients, clinicians, researchers, and pharmaceutical company staff, through a Delphi survey; (4) a consensus meeting was held to develop the final COS-TCM-DF.DiscussionCurrently, there is no COS on measuring or monitoring diabetic foot with TCM in trials or clinical practice. The COS-TCM-DF will be developed to advance the synthesis of evidence regarding the prevention and treatment of diabetic foot in TCM and to promote the standardized and consistent application of results in future studies in this field.Trial registrationRegistered with the Core Outcome Measures in Effectiveness Trials (COMET) database, December 2019 https://www.comet-initiative.org/Studies/Details/1553.
Pathogenesis, diagnosis and therapy of facial synkinesis: A systematic review and clinical practice recommendations by the international head and neck scientific group
Authors: Guntinas-Lichius Orlando , Prengel Jonas , Cohen Oded , Mäkitie Antti A. , Vander Poorten Vincent , Ronen Ohad , Shaha Ashok , Ferlito Alfio 
Published: November 2022

IntroductionPost-paralytic facial synkinesis after facial nerve injury produces functional disabilities and mimetic deficits, but also cosmetic and non-motor psychosocial impairments for the patients. These patients typically have a high and continuous high motivation for rehabilitation. The aim is to inform the affected patients and their therapeutic professionals (otorhinolaryngologist - head and neck surgeons; oral-maxillofacial surgeons, plastic and reconstructive surgeons, neurosurgeons, neurologists, and mime therapists be it speech and language therapy- or physiotherapy-based) and to provide practical recommendations for diagnostics and a stepwise systematic treatment approach of facial synkinesis.MethodsIn the first phase, a systematic literature search on the topic in PubMed and ScienceDirect starting in 2008 resulted in 132 articles. These were the basis for the review and a comprehensive series of consensus statements on the most important diagnostic tests and treatment options. In the second phase, one consensus article circulated among the membership of the International Head and Neck Scientific Group until a final agreement was reached for all recommendations.ResultsDiagnostics should include a standardized assessment of the degree of synkinesis using validated clinician-graded instruments and synkinesis-specific patient-reported outcome measures. Treatments for facial synkinesis include facial training mainly based on facial biofeedback retraining, chemodenervation with botulinum toxin, selective neurectomy, myectomy, and any combination treatment of these options.ConclusionA basic understanding of the pathomechanisms of synkinesis is essential to understand the treatment strategies. A standardized assessment of the synkinetic symptoms and the individual synkinesis pattern is needed. The first-line treatment is facial training, followed by botulinum toxin. Surgery is reserved for individual cases with unsatisfactory first-line treatment.
Endovascular treatment of an aneurysm associated with fenestration of the supraclinoid internal carotid artery: Case report and review of the literature
Authors: Filep Rareṣ Cristian , Constantin Cristian , Arbǎnaṣi Emil Marian , Mureṣan Adrian Vasile , Russu Eliza , Mǎrginean Lucian 
Published: November 2022

BackgroundFenestrations or divisions of the vascular lumen into separate channels appear to be common anatomical variations in patients with intracranial aneurysms. The most frequent sites of occurrence are the anterior communicating artery (ACom), followed by vertebrobasilar and middle cerebral artery (MCA) locations.Case presentationA 61-year-old female was brought to the emergency department after experiencing severe headache with abrupt onset, nausea, and vomiting. Clinical examination on arrival showed a drowsy patient (GCS 14), with neck stiffness, but no cranial nerve palsies or other neurological deficits (Hunt-Hess 2). Non-contrast head CT and CT angiography revealed subarachnoid and intraventricular hemorrhage (modified Fisher 4) and two saccular aneurysms, one located on the right supraclinoid ICA with peripheral calcifications, measuring 20 × 12 mm, the second on the left MCA bifurcation, 6 × 4 mm. 3D rotational angiography revealed a right ICA fenestration located between the ophthalmic (OA) and posterior communicating artery (PCom). The proximal part of the fenestration harbored a large saccular aneurysm projecting superiorly with the neck engulfing the origin of the fenestration; due to the favorable neck and geometry of the aneurysm, endovascular coil occlusion was chosen as a treatment option without balloon or stent assistance. The decision was taken to clip the MCA aneurysm.ConclusionSupraclinoid ICA fenestrations are rare anatomical variations. Endovascular treatment of supraclinoid ICA fenestration-related aneurysms is feasible and safe, with the notable concern of perforators originating from the limbs.