bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-Life Disease Monitoring in Follicular Lymphoma Patients Using Liquid Biopsy Ultra-Deep Sequencing and PET/CT
Authors: Jiménez-Ubieto Ana , Poza Maria , Martin Alejandro , Ruiz-Heredia Yanira , Dorado Sara , Figaredo Gloria , Rosa-Rosa Juan Manuel , Rodriguez Antonia , Barcena Carmen , Parrilla-Navamuel Laura , Carrillo Jaime , Perez Ricardo Sanchez , Rufian Laura , Juarez Alexandra , Rodriguez Margarita , Wang Chonwu , de Toledo Paula , Grande Carlos , Mollejo Manuela , Casado Luis , CALBACHO Maria , Baumann Tycho , Rapado Inmaculada , Gallardo Miguel , Sarandeses Pilar , Ayala Rosa , Martínez-López Joaquín , Barrio Santiago 
Published: August 2022

Abstract
In the present study, we screened 84 Follicular Lymphoma patients for somatic mutations suitable as liquid biopsy MRD biomarkers using a targeted next-generation sequencing (NGS) panel. We found trackable mutations in 95% of the lymph node samples and 80% of the liquid biopsy baseline samples. Then, we use an ultra-deep sequencing approach with 2 · 10− 4 sensitivity (LiqBio-MRD) to track those mutations on 156 follow-up liquid biopsy samples from 55 treated patients. Positive LiqBio-MRD correlated with a higher risk of progression both at the interim evaluation (HR 13.0, 95% CI 2.70–63.4, p < 0.001) and at the end of treatment (EOT, HR 14.3, 95% CI 4.4–46.4, p < 0.001). Similar results were observed by PET/CT Deauville score, with a median PFS of 19 months vs. NR (p < 0.001) at the interim and 13 months vs. NR (p < 0.001) at EOT. LiqBio-MRD and PET/CT combined identified the patients that progressed in less than two years with 89% sensitivity and 100% specificity. Our results demonstrate that LiqBio-MRD is a robust and non-invasive approach, complementary to metabolic imaging, for identifying FL patients at high risk of failure during the treatment and should be considered in future response-adapted clinical trials.
Prevalence and Risk Factors of Binge-eating Disorder among Bahraini Youth and Young Adults: a cross-sectional study
Authors: Abdulla Zahraa A.rasool Abbas , Almahmood Hend Omar , Alghasra Razan Raed , Alherz Zahra Abdulameer Sadeq , Alsharifa Husain A.Ghaffar , Qamber Seham Jamal , Alomar Nadia Aaref , Almajed Fatema Ebrahim , Almahroos Taher Reyadh , Alnajjas Zainab Ali , Alsayyad Adel Salman 
Published: August 2022

Abstract
Background Binge-eating disorder (BED) is defined as recurrent abnormal ingestion of large amount of food in a discrete period of time. BED has the highest prevalence of all eating disorders (EDs). Studies have shown strong relationship between BED and both physical and psychological factors such as obesity, depression and anxiety. This research aimed to highlight the significance and predisposing factors of BED among Bahrainis (aged 15-30).Methods959 participants (aged 15–30 years) completed self-administered online questionnaires. BED was measured using the binge eating disorder screener-7 (BEDS-7). The questionnaire also included the Patient health questionnaire -9 (PHQ-9) And general anxiety disorder -7 (GAD -7) to measure depression and anxiety, respectively. Results Out of all participants, 21.2% had binge eating symptoms. Higher BMI, restrictive diet, depression and anxiety were associated with higher binge eating. Out of all risk factors, depression had the strongest association with a value of (p<0.0001, r=0.371) . However, sociodemographic variables including age and other medical conditions showed no statistical significance. Conclusion In conclusion, the prevalence of binge-eating disorder symptoms was significantly high among the study participants. The results point out the crucial role of awareness of the interaction between obesity, depression and anxiety as potential risk factors for binge eating tendencies. Further research should seek to examine their relationship with BED.
A Longitudinal Retrospective Study of a Wearable Neuromuscular Electrical Stimulation (NMES) System Shows Significant Improvement of Arm Usage in Hemiparetic and Hemiplegic Patients
Authors: Muccio Philip , Salama Rafik , Chopra Nipun , Scheuller Josh , Durrant David , Dabrowski Edward 
Published: August 2022

Abstract
Background
Hemiparesis and hemiplegia are commonly observed motor consequences of brain injury and infarction. Brain disorders such as traumatic brain injury (TBI), stroke (cerebrovascular accident, or CVA), and cerebral palsy (CP), as well as surgical interventions, can result in aberrant motor function in the contralateral upper and lower limbs, resulting in paralysis, weakness and/or spasticity in the arm and leg. NMES has been previously used to stimulate affected muscle groups and to increase arm mobility in a variety of brain and spinal cord diseases, yet there remains a paucity of longitudinal evidence examining NMES-mediated improvements in arm usage after brain compromise.
Methods
In this retrospective cohort study (n = 38), we examined longitudinal (up to 10 years) self-reported arm usage in patients with 1) TBI, 2) stroke, 3) prior hemispherectomy, or 4) cerebral palsy who wore an NMES device, Axiobionics’ BioSleeve, and we compared this to arm usage achieved from years of conventional therapy (physical and occupational therapy) prior to use of the wearable NMES device in this study.
Results
We found that the patients saw an average increase in arm usage from 9.9–43.5% by the end of the study. This result was well represented across age groups and genders, with varying degrees across different diagnoses. Specifically, the TBI subcohort had a consistent increase in arm usage of 5.5% per year over the term of treatment.
Conclusion
This study supports the literature identifying NMES as a therapeutic intervention and complements the literature suggesting that NMES application can be used as a long-term method to increase arm usage in hemiplegic patients.
Dietary pattern and risk of dyslipidemia among pregnant women attending antenatal clinics in Kaduna South LGA, Kaduna State, Nigeria
Authors: Adeniran Sherifat Misbah , Adepoju Oluwafemi Abiodun , Anjuwon Tayo Micheal , Forcados Gilead Ebiegberi , Okola Ijeoma , James Dorcas Bolanle 
Published: August 2022

Abstract
BackgroundMaternal nutrition plays a major role in the outcome of pregnancy. Nutrition and metabolism in pregnancy determine the intrauterine environment, which influences the development of the fetus and a child's health from birth to death. Although dyslipidemia during pregnancy has long-term effects on mother and child, routine antenatal clinic examinations rarely include lipid profile checks. In the present study, we did a cross-sectional investigation on the risk of dyslipidemia and the possible contribution of diet in 130 pregnant women attending antenatal clinics in selected heath facilities in Kaduna South LGA, Kaduna State Nigeria. Both quantitative and qualitative data were collected to assess the risk of dyslipidemia among the pregnant women.ResultsThe pregnant women in this study were between the ages of 16 - 40, 77 % of which had a secondary school education, while 67 % lived on a monthly income of N5,000 - N10,000 (12.05 USD - 24.10 USD). Their diet consisted mainly of fats, oils, and milk and milk products. Indices of dyslipidemia showed that the mean total cholesterol concentration of all the pregnant women (5.73 ± 1.13 mmol/L) was above the optimal range (< 5.20 mmol/L), while more than 10 % of them were above the optimal range for low-density lipoprotein cholesterol, 40.8 % and 35.4 % were at the borderline (1.93 ± 0.14 mmol/L) and high triglycerides (2.74 ± 0.45 mmol/L) concentrations respectively. Only milk and milk products showed a positive relationship with high-density lipoprotein cholesterol (r = 0.999, p = 0.001).ConclusionsThe lipid profiles of pregnant women in our study showed that they were at risk of dyslipidemia. Therefore, routine screening of lipid profiles during antenatal care is important to provide dietitians and caregivers with valuable information on how to provide optimal nutritional care to pregnant women.
Human cytokine receptor CRLF3 is a receptor for the neuroprotective erythropoietin splice variant EV-3
Authors: Knorr Debbra Y , Polo Ignacio Rodriguez , Pies Hanna S , Schwedhelm-Domeyer Nicola , Pauls Stephanie , Behr Rüdiger , Heinrich Ralf 
Published: August 2022

Abstract

Cytokine receptor like factor 3 (CRLF3) is a conserved cytokine receptor present in all major eumetazoan taxa. Though vertebrate CRLF3 has recently been implied in the regulation of hematopoiesis, its ligand remained unidentified. CRLF3 shares structural similarity with receptors for other hematopoietic growth factors including erythropoietin, thrombopoietin and granulocyte colony-stimulating factor. Besides hematopoietic organs, these established hematopoietic cytokines and their receptors are also widely expressed in other tissues including the nervous system, where they regulate proliferation, differentiation, cell survival and other homeostatic processes. Previous studies identified insect CRLF3 as a neuroprotective receptor that can be activated by human recombinant erythropoietin, a widely accepted protective cytokine in vertebrate nervous systems. Epo’s erythropoietic functions mediated by classical Epo receptor are understood in great detail whereas Epo-mediated cytoprotective mechanisms are more complex due to involvement of additional Epo receptors and a splice variant (EV-3) with selectivity for certain unidentified receptors. In the present study, we show that human CRLF3 mediates neuroprotection upon activation with the natural Epo splice variant EV-3. We generated CRLF3 knock out iPSC lines and differentiated them towards the neuronal lineage. While apoptotic death of rotenone-challenged wild type iPSC-derived neurons was prevented by EV-3, EV-3-mediated neuroprotection was absent in CRLF3 knock out neurons. Rotenone-induced apoptosis and EV-3-mediated neuroprotection were associated with differential expression of pro- and anti-apoptotic genes. Our data characterize human CRLF3 as a receptor involved in Epo-mediated neuroprotection and identify CRLF3 as the first known receptor for EV-3.
Social Responsibility Communication In The Context Of The Socialization Function of the Media: An Examination On The Case Of The “Good Stories” Television Program
Authors: KAYA İLHAN Çağla 
Published: July 2022

İletişim teknolojilerindeki gelişmelerle birlikte birçok alanda olduğu gibi Kurumsal Sosyal Sorumluluk iletişimi de farklı bir boyut kazanmıştır. Özellikle son yıllarda televizyon programlarında sosyal medya aracılığıyla izleyici ile etkileşimli bir yayın anlayışının kazandığı görünmektedir. Bu durum Kurumsal Sosyal Sorumluluk İletişiminde halkla ilişkiler uygulamalarının televizyona yönelmesine ve yürütülen sosyal sorumluluk faaliyetlerinin geniş kitlelere yayılmasına neden olmuştur. Aynı zamanda toplumda sosyal sorumluluk anlayışının da yaygınlaşmasına neden olan bu gelişmelerle birlikte çeşitli sivil toplum kuruluşları da sosyal sorumluluk faaliyetlerine destek bulabilme fırsatı elde etmektedirler.
Bu kapsamda, çalışmanın temel amacı medyanın kurumsal sosyal sorumluluk iletişimindeki rolünü ortaya koymaktır. Bu amaçla çalışmanın ilk bölümünde tarihsel süreç içerisinde yaşanan sosyal, ekonomik ve toplumsal gelişmelerin kurumsal sosyal sorumluluk kavramının gelişimindeki etkileri ve kurumsal sosyal sorumluluk iletişiminin halkla ilişkiler açısından önemi ele alınmaktadır. Çalışmanın analiz bölümünde ise NTV’de Aralık 2019 ve Mart 2021 arasında yayınlanan “İyi Hikayeler” programı ele alınmaktadır. Bu yolla, KSS uygulamalarının televizyon programlarında işlenmesinin KSS iletişimi açısından sonuçları tartışılmaktadır.
Safeviler’de Dönüşüm Sembolü Olarak Başkentler: Kazvin ve İsfahan
Authors: BAHARLU İlgar 
Published: July 2022

Safevi Devleti’nin yaklaşık iki buçuk asırlık ömrü boyunca, manevi başkenti mahiyetinde olan Erdebil dışında üç şehir bu devlete başkentlik etmiştir. Bu şehirlerden Tebriz ve Kazvin tarihî Azerbaycan sınırları içerisindeyken, üçüncü başkent yani İsfahan ise Acem bölgesinde yer almıştır. Bu başkentlerin seçiminde dönemin siyasî, itikadî, sosyokültürel ve ekonomik şartlar belirleyici olmuştur. Devletin sınırları ve bu sınırlara göre rakip veya düşman olan komşulara yakınlığı, bölgedeki nüfus ağırlığı ve bu nüfusun etnik, itikadî ve kültürel özellikleri, dönemin ekonomik şartları ve ticaret rotaları başkentlerin seçilmesi veya değiştirilmesinde önemli rol oynamıştır.
Bu çalışmada Kazvin’in Şah Tahmasb tarafından başkent seçilmesi ve ardından I. Şah Abbas (1587-1629) döneminde başkentin Kazvin’den İsfahan’a taşınmasının nedenlerini ele alınmaktadır. Bu doğrultuda, kronikler ve seyahatnameler eşliğinde ve ayrıca konu ile ilgili çalışma yapan muasır araştırmacıların fikir ve çıkarımlarına yer verilerek Kazvin’in Tebriz’e göre avantajları ve Tebriz’in söz konusu dönemde dezavantajları ele alınmış, devamında ise Safevi Devleti’nin son başkenti olan İsfahan, aynı yöntemle mütalaaya konu edinilmiştir.
Çalışma sonucunda görülen şu ki söz konusu iki başkentin seçiminde siyasî, ekonomik, coğrafi şartlar, askeri gerekçeler ve tabi sultanların şahsî hassasiyetleri önemli rol oynamaktadır. Bunun yanı sıra her iki sultanın -Tahmasb ve I. Şah Abbas- bu kararlarında, Kızılbaşlar ve elbette bu zümrelerin inancı ve bu inanca mensup zümrelerin ülkedeki tutum, davranış ve gücü de önemli faktörlerden olmuştur. Başka bir deyimle yukarda zikredilen sebeplerin yanı sıra dönemin itikadî özellikleri ve bu itikadın temsilcilerinin devlette oynadıkları rolün de göz önünde bulundurulması gerekmektedir.
Sursat Obligation in Ayntâb Sanjak in the 17th Century
Authors: ARSLAN Hasan 
Published: July 2022

Bu tetkik, Osmanlı Devleti’nin bir değişim ve dönüşüm asrı kabul edilen 17. yüzyılda ülkenin mütevazı bir san-cağı olan Ayntab’da sürsat mükellefiyetini konu almıştır. Sürsat olağanüstü durumlarda harp ihtiyaçları kap-samında talep edilen bir yükümlülüktü. Bu yükümlülük, mahiyeti itibariyle tam bir vergi olmayıp miktarı ve fiyatı merkezî idarece belirlenen arpa, un/ekmek, koyun, sadeyağ, bal ve odun/saman gibi ürünlerin reaya tarafından tayin edilen menzillerde nakledilerek orada askerlere akçe karşılığında satılmasıdır.
Ayntab, tetkik edilen dönemde Maraş eyaletine bağlı bir sancak merkeziydi ve Ayntab ve Telbaşer kazaların-dan oluşuyordu. Liva halkı, sürsat yükümlülüğünü, doğu seferleri sırasında ekseriyetle aynen, batı yönündeki seferler esnasında da nakden yerine getirmiştir. Bu tetkikte başlıca kaynak olarak, T.C. Cumhurbaşkanlığı Devlet Arşivleri Başkanlığı bünyesindeki Osmanlı Arşivi’nin çeşitli fonlarında kayıtlı döneme ait onlarca Sürsat Zahiresi/Bedeli Defteri, Mevkufat Defteri ile Ayntab Şer’iyye Sicillerinin yanı sıra çok sayıda vesika kullanılmıştır. Kaynakların elverdiği ölçüde 17. yüzyılda Ayntab sancağı/kazası özelinde sürsat yükümlülüğünün mahiyeti/kimliği, zaman içindeki seyri ve tarh-tahsil sürecindeki işleyişi takip edilmiş. Bu süreçte dönem boyunca ortaya çıkan kimi zaman radikal kimi zaman da yavaş ancak istikralı bir tarzda arızilikten daimiliğe; aynîlikten nakdiliğe doğru olan değişim/dönüşümü gözlemlenmiş. İlk başlarda aynen talep edilen akdî ve ivazlı bu mükellefiyetin zamanla tam bir vergiye nasıl dönüştürüldüğü izlenmiştir. Bu araştırma, dönemin ve bölgenin mali/iktisadi ve içtimai hatta idari vaziyetini biraz daha aydınlatmıştır.
Regulation of urban stormwater management is not a matter of choice, but performance
Authors: Novaes Carlos Augusto Furtado de Oliveira , Marques Rui Cunha 
Published: August 2022

Abstract
Public services regulation is not a new subject and neither is its application to urban water services. Regulation is part of the set of instruments available for running public policies but does not occur alone, i.e., without institutions, the rules governing interactions between actors. However, when it comes to stormwater management, regulation is not always present, either in a soft form, through best practice guides, or in harder forms, such as command-and-control mechanisms. Literature and practice show that their absence hinders the desired provision of stormwater services. This paper seeks to present and discuss aspects related to the subject of regulation focusing not only on the need for regulation but also on the alignment between policies, institutions, and regulation (PIR) around the goal of achieving performance in delivery services. The objective and novelty of the reflections presented here consist in contributing to creating a new mentality on the need for this alignment. Aligning regulation issues within the PIR context creates opportunities to save resources and to bring better performance. This is not few and nor a matter of choice, but of the need to improve performance to face urban demographic increase, aging and obsolescence of infrastructure, and climate change challenges.
Quantifying Diyala River basin rainfall-runoff models for normal and extreme weather events
Authors: Naqi Noor Mahdi , Al-Madhhachi Abdul-Sahib T. , Al-Jiboori Monim H. 
Published: August 2022

Abstract
A variety of methods, including both modeling and non-modeling water balance techniques, are used in this study to estimate water availability allocated for different demands. The area under investigation is the shared Diyala River basin between Iraq and Iran, which is vulnerable to climate change impact and upstream control and aims to enhance watershed management. Two rainfall-runoff models were applied, the Tanh curve model and the modified Tanh curve model for runoff simulation at the Derbendkhan and Hemmrin hydrometric stations. Data from two meteorological stations in Iraq (Khanakin and Sulymania) and one in Iran (Sanandaj) for 20 hydrological years (2000–2020) was used. Some goodness of fit indicators were used to evaluate the reliability of the model outcomes, including the correlation coefficient, the root mean squared error, the mean absolute error, the deviation of runoff volume, and the index of agreement. Statistical analysis shows no statistically significant difference between observed and predicted runoff at all stations in winter, spring, and annual time scales when using the Tanh curve model, or for monthly and extreme wet events when using the modified Tanh curve method. The modified Tanh curve model was more accurate than the Tanh model and applied only to Sulymania and Sanandaj stations, as it required a considerable amount of precipitation in at least semi-humid areas.
Evaluating Sustainable Transport Indicators for Metropolitan Areas in Developing Countries: The Case of Greater Jakarta
Authors: Shiddiqi Alfa Adib Ash , Sutjiningsih Dwita , Tjahjono Tri , Darmajanti Linda , Suprayoga Gede B. 
Published: August 2022

Background:
Sustainable transport is fundamental to progress in realising the agenda of sustainable development, as a quarter of energy-related global greenhouse gas emissions come from the transport sector. In developing countries, metropolitan areas have adopted the agenda to better serve the urban population with safe, affordable, and environmentally-friendly transport systems. However, this drive must include relevant indicators and how their operationalisation can deal with institutional barriers, such as challenges to cross-sectoral coordination.

Objective:
This study aims to explore context-specific indicators for developing countries, focusing on the case of the Jakarta metropolitan area.

Methods:
Expert judgement was used to assess the selection criteria. The participants were experts from government institutions, non-government organisations, and universities.

Results:
The findings show that safety, public transport quality, transport cost, air pollution, and accessibility are contextual indicators for application in developing countries. Similarities are shown with the research results from other indexes/sets of indicators for developing countries, for example, the Sustainable Urban Transport Index (SUTI) of UN ESCAP. However, some of these indicators leave room for improvement, such as the balance between strategic and operational levels of application.

Conclusion:
Therefore, this research suggests that global sets of indicators should be adjusted before being implemented in particular developing country contexts.
Adductor Canal Block (ACB) provides Adequate Postoperative Analgesia in Patients Undergoing Total Knee Arthroplasty (TKA): Case Report
Authors: Ahmad Muhammad Ramli , Datu Madonna Damayanthie , Hardiyanti Rezki , Prasetyadhi Jokevin 
Published: August 2022

Background:
Effective postoperative multimodal analgesia facilitates early physical rehabilitation to maximize the postoperative range of motion and prevent joint adhesions following total knee arthroplasty (TKA). Adductor canal block has been reported as a supplement to multimodal analgesia protocols in patients undergoing TKA. The use of ultrasound (US) guidance has improved the success rates of the blocks compared with blind approaches.

Case Presentation:
This report described two elderly patients undergoing TKA with ACB as postoperative pain management, resulting in adequate pain control during the postoperative period.

Conclusion:
Adductor canal block can be used to optimize multimodal analgesia by reducing opioid requirements and enhancing recovery after TKA.
Influence of Digital Intervention Messaging on Influenza Vaccination Rates Among Adults With Cardiovascular Disease in the United States: Decentralized Randomized Controlled Trial
Authors: Marshall Nell J , Lee Jennifer L , Schroeder Jessica , Lee Wei-Nchih , See Jermyn , Madjid Mohammad , Munagala Mrudula R , Piette John D , Tan Litjen , Vardeny Orly , Greenberg Michael , Liska Jan , Mercer Monica , Samson Sandrine 
Published: July 2022

Background
Seasonal influenza affects 5% to 15% of Americans annually, resulting in preventable deaths and substantial economic impact. Influenza infection is particularly dangerous for people with cardiovascular disease, who therefore represent a priority group for vaccination campaigns.

Objective
We aimed to assess the effects of digital intervention messaging on self-reported rates of seasonal influenza vaccination.

Methods
This was a randomized, controlled, single-blind, and decentralized trial conducted at individual locations throughout the United States over the 2020-2021 influenza season. Adults with self-reported cardiovascular disease who were members of the Achievement mobile platform were randomized to receive or not receive a series of 6 patient-centered digital intervention messages promoting influenza vaccination. The primary end point was the between-group difference in self-reported vaccination rates at 6 months after randomization. Secondary outcomes included the levels of engagement with the messages and the relationship between vaccination rates and engagement with the messages. Subgroup analyses examined variation in intervention effects by race. Controlling for randomization group, we examined the impact of other predictors of vaccination status, including cardiovascular condition type, vaccine drivers or barriers, and vaccine knowledge.

Results
Of the 49,138 randomized participants, responses on the primary end point were available for 11,237 (22.87%; 5575 in the intervention group and 5662 in the control group) participants. The vaccination rate was significantly higher in the intervention group (3418/5575, 61.31%) than the control group (3355/5662, 59.25%; relative risk 1.03, 95% CI 1.004-1.066; P=.03). Participants who were older, more educated, and White or Asian were more likely to report being vaccinated. The intervention was effective among White participants (P=.004) but not among people of color (P=.42). The vaccination rate was 13 percentage points higher among participants who completed all 6 intervention messages versus none, and at least 2 completed messages appeared to be needed for effectiveness. Participants who reported a diagnosis of COVID-19 were more likely to be vaccinated for influenza regardless of treatment assignment.

Conclusions
This personalized, evidence-based digital intervention was effective in increasing vaccination rates in this population of high-risk people with cardiovascular disease.

Trial Registration
ClinicalTrials.gov NCT04584645; https://clinicaltrials.gov/ct2/show/NCT04584645