bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Domestic Investment Matter? A Multivariate Time Series Analysis of Energy-CO2 Emission-Growth Nexus in Ghana
Authors: Bekoe Bernard Boamah , Chen Junfei , Tougem Tasinda Odette , Nketiah Emmanuel , Sakuwunda Kulena 
Published: November 2022

Abstract
The economic cost of Greenhouse gas (GHG) emissions to African economies have increased. Therefore, the GHG emissions and their concomitant effect on the environment are fast becoming costly to emerging economies like Ghana. Hence, the justification for the growing literature on the subject. This study employed the Autoregressive Distributive lag (ARDL) bounds test and Granger causality techniques with data from 1983 to 2014. The study examines the dynamic relationship between income growth, power consumption, and carbon dioxide (CO2) emissions in Ghana, capturing the role of domestic investment and foreign direct investment (FDI) in the nexus. All variables were found to be cointegrated in the long run based on the bounds test. The Granger causality test indicates a unidirectional causality from energy consumption to CO2 emissions and economic growth. Further, a unidirectional causality from CO2 to economic growth was found in Ghana. Due to the significant effect of domestic investments on CO2 emissions reduction in both the short run and long run, the study recommends policymakers to adopt policies that may increase domestic capital in place of FDI, which has been proven to exacerbate environmental degradation in host countries.
Virulence of Beauveria sp. and Metarhizium sp. fungi towards Fall armyworm (Spodoptera frugiperda)
Authors: Apirajkamol Nonthakorn (Beatrice) , Hogarty Timothy Michael , Mainali Bishwo , Taylor Phillip Warren , Walsh Thomas Kieran , Tay Wee Tek 
Published: November 2022

Abstract
Since 2016, the fall armyworm (Spodoptera frugiperda, J.E. Smith) has spread from the Americas to invade many regions of the world, including Australia in early 2020. The development of effective pest management strategies for S. frugiperda is a high priority for crop protection. In the invasive range, the degree to which endemic biological control agents can constrain S. frugiperda remains sparsely investigated. This study examines 11 isolates of fungi including six Beauveria isolates and five Metarhizium isolates from Oceania for their potential as S. frugiperda biocontrol. Two Beauveria isolates (B-0571, B-1311) exhibited high virulence toward S. frugiperda caterpillars and adults. The overall mortalities over seven days in 3rd and 6th instar caterpillars and moths (respectively) for B-0571 was 82.81 ± 5.75, 61.46 ± 6.83, and 93.75 ± 3.61, and for B-1311 was 73.72 ± 2.51, 71.88 ± 5.41, and 97.92 ± 2.08%. The majority of deaths in the caterpillars occurred within the first 24 hours (3rd instar control 0.74 ± 0.33%, B-0571 73.96 ± 7.85 and B-1311 62.08 ± 3.67%; 6th instar control 0%, B-0571 66.67 ± 11.02% and B-1311 62.5 ± 9.55%). Infection from both isolates fully prevented reproduction in surviving S. frugiperda females. The two isolates, however, cause a significantly lower mortality in a native noctuidae species: Helicoverpa armigera (3rd instar B-0571 44.79 ± 4.54% and B-1311 19.80 ± 7.51%). The discovery of two fungal isolates with high virulence to S. frugiperda caterpillars and adults opens new avenues for the development of biological control tools for this invasive moth pest. Such tools may also provide additional options for control of native pest lepidoptera, and reduce selection pressure for resistance to Bt and synthetic insecticides.
A preliminary study of real-time imaging for MR guided vascular intervention and image quality assessment
Authors: Liu Kunkun , Dai Weibin , Peng Yueyou , Shi Tianfeng , Liu Tingting , Song Ningning , Jiang Yueluan , Kang Yunhui , Meng Yanfeng 
Published: November 2022

Abstract
Background
Real-time MRI provides radiation-free alternative to X-ray guided interventions, enables superb tissue imaging without administration of contrast agents. In this study, we proposed an 3T MRI system, and evaluated the image quality of real-time sequences for MR compatible guidewire and balloon.
Methods
MR guided intervention system were setup with 3T MR scanner and MR compatible monitor. Real-time sequences (FLASH and TrueFISP) were optimized and evaluated in the interventional procedure with a 3D printing aortic phantom, MR compatible guidewire and balloon catheter. After the images were obtained, the image quality was evaluated objectively, and subjectively. T tests was used to analyse the results.
Results
The temporal resolution of both sequences were 2 frames/s and spatial resolution was 1.1mm×1.1mm×10mm. For objective assessment, the TrueFISP sequence showed higher SNR and CNR than the FLASH sequence. Image uniformity and geometric distortion did not show significant difference. The subjective scores showed FLASH was higher than TrueFISP, because of moderate artefacts of guidewire and good visualization of balloon catheter.
Conclusions
In conclusion, the study demonstrates the MR real-time imaging, FLAH sequence, is feasible of guiding cardiovascular interventions.
Quantum metrology with ultracold chemical reactions
Authors: Fischer Uwe 
Published: November 2022

Abstract
Chemical chain reactions are known to enable extremely sensitive detection schemes in chemical, biological, and medical analysis, and have even been used in the search for dark matter. Here we show that coherent, ultracold chemical reactions harbor great potential for quantum metrology: In an atom-molecule Bose-Einstein condensate (BEC), a weak external perturbation can modify the reaction dynamics and lead to the coherent creation of molecules in an atom-dominant regime which can be selectively detected with modern spectroscopic techniques. This
promises to substantially improve the viability of
previously proposed BEC-based
sensors for acceleration, gravitational waves, and other physical quantities, including the detection of dark matter,
that so far relied on the detection of the tiny density modulations caused by the creation of single phonons.
Diagnostic value of GDF10 for the tumorigenesis and progression in lung squamous cell carcinoma
Authors: Mei Peiyuan , Chen Jiaping , Meng Wangyang , Wang Yangwei , Meng Yunchong , Zhao Rong , Lin Wei , Liao Yongde , Xiao Han 
Published: November 2022

AbstractBackground Lung squamous cell carcinoma (LUSC) remains a poor survival rate, calling for a novel molecular with diagnostic and treatment value. Accumulative evidence found bone morphogenetic proteins (BMPs) and their receptors (BMPRs) play important roles in tumorigenesis and progression, however, was lack of comprehensive analysis of their expression in LUSC. Methods . R/Limma package was performed to analyze the differential expression of BMPs/BMPRs in combination of TCGA and GTEx, and explore their expression characteristics with LUSC tumorigenesis in GSE33479. Meanwhile, survminer packages were performed to explore their prognostic value and correlation of clinical features in LUSC. Then, the potential diagnostic biomarkers and mechanisms associated with LUSC progression were further explored through weight gene correlation network analysis (WGCNA). At the same time, LASSO analysis was performed to construct a prognostic risk model for LUSC with the differential expression of BMPs/BMPRs as the core. Finally, the specimens were collected from 33 patients with LUSC and detected by IHC to confirm the relationship between protein levels of the above diagnostic BMPs/BMPRs and progression of LUSC. Results On the whole, 2 upregulated genes (BMP8A, BMP7) and 8 downregulated genes (BMP2, BMP5, BMP6, GDF5, GDF7, GDF10, ACVRL1 and BMPR2) were identified differentially expressed genes in LUSC. In these differentially expressed genes, GDF10 was only a significant correlation with pathological T stage of LUSC (p < 0.001). The co-expressed network showed that the positively related magenta module (Coefficient:0.93, p = 1.4e-70 < 0.001) and the negatively correlated turquoise module (Coefficient:0.89, p = 1e-200) are significantly associated with GDF10. Meanwhile, combining 72 significantly down-regulated genes in magenta module and 351 significantly up-regulated genes in turquoise module together, a prognostic risk model was constructed with GDF10 as the core gene and 5 hub genes (HRASLS, HIST1H2BH, FLRT3, CHEK2 and ALPL) (HR:1.73, 95%CI:1.32–2.28, p = 1e-04 < 0.001). At last, immunohistochemical results verified that the protein expression level of GDF10 decreased with the tumorigenesis and progression of LUSC. Conclusion Both mRNA and protein expression levels of GDF10 acted as an independent protective factor in the tumorigenesis and progression of lung squamous cell carcinoma. As a result, it may be a potential diagnostic biomarker and a new therapeutic target for LUSC.
Analysis of mental health status and influencing factors of medical staff during static management of the COVID-19 epidemic: a cross-sectional study
Authors: Liu Jiawei , Zhou Xiaoli , Chen Hui 
Published: November 2022

Abstract
Objective
To assess the mental health of medical staff as the COVID-19 pandemic is being managed statically.
Methods
By a convenience sampling method, 560 medical personnel who worked in a certain region of China throughout the static management period were chosen as the research objects. To obtain information, the basic data questionnaire, the COVID-19 epidemic perception questionnaire, the psychological questionnaire for public health emergencies, the psychological resilience scale, and the social support scale were all implemented.
Results
The psychological questionnaire for public health emergencies of medical staff had a total score of 2.03 (0.87, 2.77), with scores for each dimension of depression, neurasthenia, fear, anxiety, and hypochondriasis being 0.56 (0,0.833), 0.425 (0.2,0.6), 0.57 (0.17,0.83), and 0.207 (0,0.4), respectively. Multivariate linear regression analysis demonstrated that monthly salary, whether there was physical disease in the past, apartment, whether to work in the isolation area, attitude toward static management, psychological resilience score, social support score, and emotional knowledge score entered the influencing factor model of mental health of medical personnel (F = 4.759, P < 0.001), which could independently explain 33.8% of the total variation.
Conclusion
With static administration, the level of psychological stress experienced by medical workers during public health emergencies is excessive. To safeguard the physical and emotional health of medical workers, managers should improve the management of public health emergencies, establish a scientific and coordinated training program, and provide psychological assistance in a timely manner.
Posterior corneal elevation changes after small incision lenticule extraction
Authors: Liu Ming , Song Wenting , Chen Yuanyuan , Pan Hongbiao , Luo Dan , shi Lei 
Published: November 2022

Abstract
Background: To investigate posterior corneal surface (PCS) elevation changes and influencing factors after SMILE.
Methods: A total of 285 patients (559 eyes) were analyzed. The PCS elevation before the operation, 1 day, 1 week and 1 month after the operation were recorded, including cornea apex and the 2 mm, 4 mm, and 6 mm circle. Analyzed the correlation between the changes with age, equivalent spherical refraction, corneal thickness, lenticule thickness, corneal cap thickness, lenticule diameter, residual corneal thickness, corneal cap thickness/corneal thickness, lenticule thickness/corneal thickness and PCS curvature.
Results: There were significant differences in the PCS elevation of the center and 2 mm, 4 mm, and 6 mm circles at 1 day, 1 week and 1 month postoperation (P<0.0001) comparing to preoperation. There were no significant changes after 1 day (P>0.05). At the center and 2 mm circle, the PCS moved backward after the operation, which were positively correlated with preoperative values of K1, K2 and Km on the PCS (r>0, P<0.05). At the 4 mm and 6 mm circles, the PCS moved forward after the operation, while it was negatively correlated with the preoperative K1, K2 and Km of the PCS (r<0, P<0.05). There was no other influencing factors.
Conclusions: The PCS elevation changed significantly on the first day after SMILE surgery and then stayed stable. Within the safe range, the possibility of PCS expansion after SMILE is rare. SMILE surgery should be carefully selected for patients with excessive or excessively small PCS curvature.
Inference of fixed bias probe measurements - A machine learning approach
Authors: Olowookere Akinola , Marchand Richard , Buchert Stephan C 
Published: November 2022

Abstract
A new approach is presented to improve inferences made with Langmuir probe measurements in plasma while providing estimates of uncertainties.
The technique makes use of a combination of computer simulations, analytic approximations, and multivariate regressions.
It involves training inference models using currents collected by two probes, biased at different fixed potentials relative to a satellite.
An advantage with fixed bias probes is their higher temporal and spatial resolution, compared to the more standard mode operation where bias voltages are swept in time.
Synthetic data used to train models are constructed from kinetic simulations with assumed satellite and plasma parameters relevant to satellites in Low Earth Orbit (LEO).
Simulations are made assuming a truncated Swarm geometry, the two Electric Field Instruments (EFI) Langmuir probes, and different satellite
potentials in the range [-3, 0] V.
Models are constructed using two approaches, with two-tuples of currents as independent variables. Inference skills are assessed with different metrics, from comparisons between inferred plasma and satellite parameters, and known values used as input in the simulations.
The models are then applied to infer the same physical parameters, using Swarm A in situ measured currents, and comparing them with values reported on the Swarm data portal.
Inferences are consistent with values reported on the Swarm data portal, although it is not possible at this point to determine if, and if so, to what extent, the simulation-regression approach leads to better inferences.
Characterization and identification of the powdery mildew resistance gene in wheat breeding line ShiCG15-009
Authors: Zhang Wenjing , Yu Ziyang , Wang Dongmei , Xiao Luning , Su Fuyu , Mu Yanjun , Zheng Jianpeng , Li Linzhi , Yin Yan , Jin Yuli , Yu Tianying , Ma Pengtao 
Published: November 2022

Abstract
Powdery mildew, caused by Blumeria graminis f. sp. tritici (Bgt), is a serious fungal disease that critically threatens the yield and quality of wheat. Utilization of host resistance is the most effective and economical method to control this disease. In our study, a wheat breeding line ShiCG15-009, released from Hebei Province, was highly resistant to powdery mildew at all stages. To dissect its genetic basis, ShiCG15-009 was crossed with the susceptible cultivar Yannong 21 to produce F1, F2 and F2:3 progenies. After genetic analysis, a single dominant gene, tentatively designated PmCG15-009, was proved to confer resistance to Bgt isolate E09. Further molecular markers analysis showed that PmCG15-009 was located on chromosome 2BL and flanked by markers XCINAU130 and XCINAU143 with the genetic distances 0.2 and 0.4 cM, respectively, corresponding to a physic interval of 705.14-723.48 Mb referred to the Chinese Spring reference genome sequence v2.1. PmCG15-009 was most likely a new gene differed from the documented Pm genes on chromosome 2BL since its different origin, genetic diversity, and physical position. To analyze and identify the candidate genes, six genes associated with disease resistance in the candidate interval were confirmed to be associated with PmCG15-009 via qRT-PCR analysis using the parents ShiCG15-009 and Yannong 21 and time-course analysis post-inoculation with Bgt isolate E09. To transfer PmCG15-009 using marker-assisted selection (MAS), 18 closely or co-segregated markers were evaluated and confirmed to be suitable for tracing PmCG15-009, when it was transferred into different wheat cultivars via conventional hybridization.
Analyses of phylogeny and genetic evolution of Capripoxvirus in North and Northwest of China
Authors: Wu jinyan , Sun Jianfei , Du Guoyu , Zhang Cheng , Cao Xiaoan , Li Lingxia , Lan Xi , He Jijun , shang youjun 
Published: November 2022

Abstract
Capripoxviruses (CaPVs) mainly infect sheep, goats, and cattle, which cause rashes or knots, fever, and systemic papillae in flocks and herds. It is a highly infectious disease of major economic concern to the animal husbandry industry. This disease is widely spread all over the world, including China. In this study, we collected the tissue samples from goats, sheep, and cattle in the Northern and Northwestern of China, where the flocks and herds industries gather. Sequence alignment and phylogenetic tree analysis of GPCR, P32, and RPO30 showed that the two SPPV (Sheep poxvirus), two GTPV (Goat poxvirus), and one LSDV (Lumpy skin disease virus) strains were isolated in our works, respectively. Data of recombination analysis showed that SPPV strains usually has a recombination event in the GPCR gene. Except for GPCR genes, analysis of codon usage bias indicated that greater mutation pressure was found in GTPV and LSDV strains, and other genes were mainly affected by natural selection pressure in the evolutionary process. Selection pressure analysis also showed that SPPV, GTPV, and LSDV strains had a tendency to evolve toward adaptability. Taken together, this study shows how CaPVs have changed over time at the molecular and genetic levels in the North and Northwest of China. It also serves as a reference for future clinical and molecular research on CaPVs.
Evaluation of the Effects of Curcumin and its Two Nanoforms on the Cancerous and Normal Cell Lines in the Presence of Radiation
Authors: Toossi Mohammad Taghi Bahreyni , Vaziri Fereshteh , Gholamhoseinian Hamid , Azimian Hosein , Jaafari Mahmoud Reza , Negah Sajjad Sahab , Dolat Elham 
Published: November 2022

Abstract

The medicinal properties of herbs attract the public and the medical community’s attention. Turmeric is considered a natural substance with many health effects, and curcumin, as effective component of turmeric, is known to have several usefulness for human health. The dual effect of the curcumin in the presence of radiation as a radiosensitizer and radioprotector for tumor and normal cells, respectively, increases treatment efficacy. In this study we have investigated the effect of X-ray radiation (6 MV) and bulk curcumin, nano micelles, and nanoniosome of curcumin on two colorectal cancer cell lines and human fibroblast cells using MTT, colonogenic assay, and annexin-PI test. Based on the results, curcumin and the two formulations used decreased the viability of both cell lines, however the final results depend on the curcumin concentration. The results of the dose-response curve displayed that the survival fraction in the presence of nanomicelles had a dual function on cancerous and normal cells due to a radiosensitivity and radioprotective effects on cancerous and normal cells, respectively. However, these effects were not shown in the presence of nanoniosome of curcumin. Curcumin in all 3 forms increased apoptotic cells in both cell lines without any radiation. However, the apoptotic cells increased in exposed cancerous cells for all forms of curcumin, the apoptotic HFF cells decreased after radiation in presence of them. In conclusion, curcumin is considered a radiosensitizer in tumor cells, and its radioprotection properties need more studies.
Comparison of efficacy and safety between third-dose triple and third-dose dual antihypertensive combination therapies in patients with hypertension
Authors: Sung Ki-Chul , Hong Soon Jun , Rhee Moo-Yong , Jeong Myung-Ho , Kim Dae-Hee , Lim Sang-Wook , Park Kyungil , Lee Jin Bae , Kim Seok-Yeon , Cho Jin-Man , Cho Goo-Yeong , Heo Jung-Ho , Kim Sang-Hyun , Lee Hae-Young , Kim Weon , Cho Deok-Kyu , Park Sungha , Shin Jinho , Pyun Wook-Bum , Kwon Kihwan , Rha Seung-Woon , Jung Jin-A 
Published: November 2022

Abstract
Purpose

We compared the efficacy and safety of third-standard-dose triple and third-standard-dose dual antihypertensive combination therapies in patients with mild to moderate hypertension.

Methods

This was a phase II multicenter, randomized, double-blind, parallel-group trial. After a 4-week placebo run-in period, 245 participants were randomized to the third-dose triple combination (ALC group; amlodipine 1.67 mg + losartan potassium 16.67 mg + chlorthalidone 4.17 mg) or third-dose dual combination (AL group; amlodipine 1.67 mg + losartan potassium 16.67 mg, LC group; losartan potassium 16.67 mg + chlorthalidone 4.17 mg, AC group; amlodipine 1.67 mg + chlorthalidone 4.17 mg) therapy groups and followed up after 8 weeks.

Results

The mean systolic blood pressure (BP) reduction was − 18.3 ± 13.2, -13.0 ± 13.3, -16.3 ± 12.4, and − 13.8 ± 13.2 mmHg in the ALC, AL, LC, and AC groups, respectively. The ALC group showed significant systolic BP reduction compared to the AL and AC groups at weeks 4 (p = 0.010 and p = 0.018, respectively) and 8 (p = 0.017 and p = 0.036, respectively). The proportion of systolic BP responders was significantly higher in the ALC group (42.6%) than in the AL (22.0%), LC (23.3%), and AC (27.1%) groups (p = 0.013, p = 0.021 and p = 0.045, respectively) at week 4. The proportion of systolic and diastolic BP responders was significantly higher in the ALC group (59.7%) than in the AL (39.3%) and AC (42.4%) groups (p = 0.022 and p = 0.049, respectively) at week 8.

Conclusion

Third-standard-dose triple antihypertensive combination therapy demonstrated early effective BP control compared to third-standard-dose dual combination therapies, without increasing adverse drug reactions in patients with mild-to-moderate hypertension.

Trial Registration

NCT04959305
Out-of-plane electrokinetics via pumping potential achieved by 100 nm-thin polyethylene nanomembranes
Authors: Sun Weilong , Wang Zirui , Yang Kailin , Chen Jingyu , Wu Kai , Zhang Qin , Li Faming , Liu Mingzhen , Li Runlai , Fu Qiang 
Published: November 2022

Abstract
Droplet-induced electricity generation, as one of the most emerging environmental energy harvesting technologies, has been extensively investigated for nearly a decade. Its interaction between ions (in droplets), electrons (in conductors, e.g. graphene), and charges (on the substrate surface) is the key to electricity generation. However, the indirect interaction between ions and charges due to the shielding effect from conductors, inevitably suppresses device performance and limits conductor selection. Here, we addressed above issues by proposing an out-of-plane electrokinetic effect based on a 100 nm-thick negatively charged polyethylene nanomembrane, providing direct interactions between ions and charges, with the shielding effect of conductors eliminated. This new paradigm of electrokinetics could induce a persistent potential for 6 hours (first enduring DEG) and a specific power of 177.2 nW/µL (highest droplet-induced electrokinetics). With new device topologies and extensive conductor materials unlocked, this work is expected to elucidate more physical picture of electrokinetics.