bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sick or Sad? A Qualitative Study on How Dutch GPs Deal With Sadness Complaints Among Young Adults
Authors: van Dijk Eva L. , van Tol Donald G. , Diemers Agnes D. , Wienen Albert W. , Batstra Laura 
Published: January 2022

Feelings of sadness among young adults related to a certain phase of life or to societal factors run the risk of being interpreted as an individual medical problem. Therefore, healthcare professionals should more often widen their perspective and consider de-medicalization as being part of their professional responsibility too. This article presents results from a qualitative interview conducted with 13 GPs in different phases of their career to get more insight into the way they deal with complaints of sadness among young adults. All participants acted proactively but in different ways. Based on the interviews, a typology of three types of general practitioners has been created: the fast referrer, the expert, and the societal GP. There seems to be a paradox in the way GPs think about de-medicalization on a macro level and the way they act on a micro level. Elaborating on Parsons’(1951) classical concept of the sick role, this study introduces the term semi-legitimized sick role to clarify this paradox. The third type, “the societal GP”, appears to be the most able to show a more multifactorial view on complaints of sadness. Therefore, this type connects the most to a course of de-medicalization.
Impact on Quality of Life of Seton Placing in Perianal Crohn's Disease
Authors: Angriman Imerio , Tomassi Monica , Ruffolo Cesare , Bordignon Giovanni , Saadeh Luca , Gruppo Mario , Pucciarelli Salvatore , Bardini Romeo , Scarpa Marco 
Published: January 2022

IntroductionOften, in perineal Crohn's disease (CD), a seton is placed to guarantee a constant drainage and prevent septic complication while biologic therapy is ongoing. This study aimed to assess the long-term quality of life after surgery for perineal CD in relation to seton placing.Patients and MethodsData of 65 consecutive patients with CD and non-CD operated on from 2014 to 2019 for perianal fistula or abscess were retrieved. Forty-three had CD and 14 of them had a seton placed during surgery and they kept it on while they had anti-TNF-alpha therapy. Patients were interviewed with the Cleveland Global Quality of Life (CGQL) and SF-12 quality of life questionnaires. Disease activity was defined as Harvey-Bradshaw Index (HBI) and Perianal Disease Activity Index (PDAI). Comparisons between groups were carried out with the nonparametric tests, and multiple regression models were used to assess predictors of quality of life.ResultsThe total CGQL score and SF-12 mental component score (MCS) were significantly higher (and thus better) in the seton group than in patients treated without seton. On the contrary, SF-12 physical component score (PCS) was not different between the two groups. HBI was significantly better in patients in the seton group. At multivariate analysis, seton placement and HBI were confirmed to be independent predictors of long-term SF-12 MCS whereas only HBI confirmed to be a predictor of total CGQL score.ConclusionsSeton placing during anti-TNF-alpha therapy is independently associated with a better MCS. Unexpectedly, this device, instead of to cause psychological distress, seems to assure patients during their biologic therapy providing psychological benefit beyond the mere medical effect.
Incidence and Predictors of Synchronous Bone Metastasis in Newly Diagnosed Differentiated Thyroid Cancer: A Real-World Population-Based Study
Authors: Qi Lin , Zhang Wenchao , Ren Xiaolei , Xu Ruiling , Liu Chaoqian , Tu Chao , Li Zhihong 
Published: January 2022

BackgroundClinical and sociodemographic characteristics of differentiated thyroid cancer (DTC) patients with synchronous bone metastasis (SBM) remain unclear. This real-world study aimed to elucidate the incidence and prognosis of DTC patients with SBM using population-based data.MethodsData of patients with newly diagnosed DTC from 2010 to 2016 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. Multivariable logistic regression analysis was utilized to identify predictors of developing SBM in patients with DTC and was further evaluated by receiver operator characteristics (ROC) analysis. Multivariable Cox regression was applied to identify prognostic factors associated with overall survival (OS) and cancer-specific survival (CSS).ResultsA total of 67,176 patients with DTC were screened from the database, with 0.36% (244/67,176) developed SBM. The age-adjusted incidence of SBM in patients with DTC was relatively stable during the study period with an average annual percentage change (AAPC) of 2.52. Multivariable logistic regression analysis recognized seven factors (older age, male gender, black race, other races, follicular histology, the American Joint Committee on Cancer (AJCC) T2, T3, T4 staging, and N1 staging) as predictors of developing SBM among the entire cohort, with the value of area under the curve (AUC) of 0.931 (95% CI: 0.915–0.947). The median survival time of DTC patients with SBM was 22 months (interquartile range, 7–47 months). The multivariable Cox regression analysis indicated multiple metastatic sites, surgical procedures, and chemotherapy as predictors for the survival of patients.ConclusionsPredictors and prognostic factors of SBM in patients with DTC were identified in this study. Patients with risk factors should be given more attention in clinical practice.
On Farm Emergency Slaughter and Emergency Killing of Acutely Injured Cattle: Analysis of Guidelines From Five Jurisdictions
Authors: McDermott Paul , McKevitt Aideen , Hanlon Alison 
Published: January 2022

BackgroundIn July 2009, the Farm Animal Welfare Advisory Council (FAWAC) in the Republic of Ireland published Animal Welfare Guidelines for the Management of Acutely Injured Animals on Farm in support of a new Irish regulation designed to permit on-farm emergency slaughter (OFES) of cattle. The purpose of this study was to evaluate the FAWAC guidelines, to determine if they remain fit for purpose by comparing them with five guidelines on the management of acutely injured cattle from four jurisdictions purposively selected because of their relevance to OFES, and to represent geographical and organisational diversity; The United Kingdom, Australia, New Zealand and British Columbia/Canada.MethodologyContent and Thematic Analysis were used to compare the incidence and frequency of themes in the six guidelines using NVIVO 12.ResultsHumane killing and slaughter of animals and the prevention of unnecessary suffering at time of killing were emphasised in all guidelines. Thematic Analysis identified seven primary themes (“parent nodes”): animal welfare; decision tree; certification; legislation; stakeholders; transport and; veterinary ethics. Parent nodes encompassed 26 secondary themes (“child nodes”) including casualty slaughter, on-farm emergency slaughter, euthanasia, unnecessary suffering, animal owner, private veterinary practitioner, official veterinarian and fitness for transport. Guidelines outlined stakeholders' roles in relation to all aspects of managing acutely injured cattle. Results showed similarities between FAWAC, the British Cattle Veterinary Association and the British Columbian/Canadian guidelines in relation to OFES as a method to address acutely injured cattle. OFES is not allowed in Australia or New Zealand as a method of managing acutely injured cattle.ConclusionsAnimal welfare guidelines play a pivotal role in informing all stakeholders involved in the management of acutely injured cattle. Guidelines vary from prescriptive standard operating procedures on actions that should be undertaken for food safety reasons, to descriptive guidance upholding practicalities in relation to equipment and methods to be used in managing acutely injured cattle not meant for human consumption. The FAWAC guidelines remain substantially relevant today and consistent with other welfare guidelines published in the jurisdictions that formed part of the study. However, they need to be reviewed to align with current regulations.
Should We Delay the Second COVID-19 Vaccine Dose in Order to Optimize Rollout? A Mathematical Perspective
Authors: Berkane Soulaimane , Harizi Intissar , Tayebi Abdelhamid , Silverman Michael S. , Stranges Saverio 
Published: January 2022

Objectives: With vaccination shortage persisting in many countries, adopting an optimal vaccination program is of crucial importance. Given the slow pace of vaccination campaigns globally, a very relevant and burning public health question is whether it is better to delay the second COVID-19 vaccine shot until all priority group people have received at least one shot. Currently, many countries are looking to administer a third dose (booster shot), which raises the question of how to distribute the available daily doses to maximize the effectively vaccinated population.Methods: We formulate a generalized optimization problem with a total of uT=∑i=1nui vaccine doses, that have to be optimally distributed between n different sub-populations, where sub-population ui represents people receiving the ith dose of the vaccine with efficacy αi. The particular case where n = 2 is solved first, followed by the general case of n dose regimen.Results: In the case of a two dose regimen, if the efficacy of the second dose is less than (or equal to) twice the efficacy of the first dose, the optimal strategy to maximize the number of effectively vaccinated people is to delay the second vaccine as much as possible. Otherwise, the optimal strategy would consist of administering the second dose as quickly as possible. In the general case, the optimal vaccination strategy would be to administer the k − th dose corresponding to the index providing the maximum inter-dose efficacy difference (αi − αi−1) for all possible values of i ∈ {1, … , n}, with α0 = 0.Conclusion: Our results suggest that although extending the interval between doses beyond 12 weeks was likely optimal earlier in the pandemic, the reduced single dose efficacy of vaccines against the delta variant make this approach no longer viable.
Impact of Different Anthropogenic Environments on Ticks and Tick-Associated Pathogens in Alsace, a French Region Highly Endemic for Tick-Borne Diseases
Authors: Boyer Pierre H. , Barthel Cathy , Mohseni-Zadeh Mahsa , Talagrand-Reboul Emilie , Frickert Mathieu , Jaulhac Benoit , Boulanger Nathalie 
Published: January 2022

Ticks and tick-borne diseases have spread over the last decades. In parallel, the incidence in humans, accidental hosts for most of these zoonotic diseases, has increased. This epidemiological intensification can be associated with anthropogenic alterations of forest ecosystems and animal biodiversity, but also with socioeconomic changes. Their proliferation is largely due to human-induced effects on the factors that favor the circulation of these infectious agents. We selected different types of anthropogenic environments in Alsace, a region endemic for tick-borne diseases in France, to better understand the impact of human interventions on tick populations and tick-borne disease incidence. Ticks were collected in one golf course, three urban parks, one mid-mountain forest, and one alluvial forest that is currently part of a protected natural area. Ixodes ricinus was found primarily in humid vegetation, which is favorable for tick survival, such as grounds populated with trees and covered with leaf litter. We also observed that reforestation and high animal biodiversity in a protected area such as the alluvial forest led to a greater number of ticks, including both Ixodes ricinus and Dermacentor reticulatus, as well as to a higher prevalence of pathogens such as Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum, Borrelia miyamotoi, and Rickettsia raoulti.
First Outbreak of NDM-1-Producing Klebsiella pneumoniae ST11 in a Portuguese Hospital Centre during the COVID-19 Pandemic
Authors: Mendes Gabriel , Ramalho João F. , Duarte Aida , Pedrosa Adriana , Silva Ana Cristina , Méndez Lucía , Caneiras Cátia 
Published: January 2022

New Delhi metallo-β-lactamase (NDM) carbapenemase has been considered a global threat due to its worldwide widespread in recent years. In Portugal, a very low number of infections with NDM-producing Enterobacterales has been reported. A total of 52 strains from 40 patients and 1 environmental sample isolated during COVID-19 pandemic were included in this study. Wholegenome sequencing (WGS) was performed on 20 carbapenemase-producing strains, including 17 NDM-1-producing Klebsiella pneumoniae ST11-KL105 lineage strains, one NDM-1-producing Escherichia coli ST58 strain and one KPC-3-producing K. pneumoniae ST147 strain, recovered from a total of 19 patients. Of interest, also one NDM-1-producing K. pneumoniae ST11-KL105 was collected from the hospital environment. Genome-wide phylogenetic analysis revealed an ongoing dissemination of NDM-1-producing K. pneumoniae ST11 strains (n = 18) with the same genetic features seen across multiple wards. Furthermore, the ST58 E. coli strain, collected from a patient rectal swab that was also colonised with a K. pneumoniae strain, also showed the IncFIA plasmid replicon and the blaNDM-1 gene (preceded by IS30 and followed by genes bleMBL, trpF, dsbC, cutA, groES and groEL). The blaNDM-1 is part of Tn125-like identical to those reported in Poland, Italy and India. The blaKPC-3 K. pneumoniae ST147-KL64 strain has the genetic environment Tn4401d isoform. In conclusion, herein we report the molecular epidemiology, resistome, virulome and mobilome of the first NDM-1 carbapenemase outbreak caused by K. pneumoniae ST11-KL105 lineage during the COVID-19 pandemic in Portugal. Moreover, the outbreak strains characterised included seventeen different patients (infected and colonised) and one environmental sample which also emphasises the role of commensal and hospital environment strains in the dissemination of the outbreak.
HUBUNGAN PERSEPSI DUKUNGAN ORANG TUA DENGAN PENGUASAAN KOSAKATA ANAK USIA 6-7 TAHUN
Authors: Amelia Zahrina 
Published: January 2022

--- Penelitian korelasional ini bertujuan untuk melihat hubungan persepsi dukungan orangtua sosial terhadap penguasaan kosakata usia 6-7 tahun di Wilayah Jakarta Selatan. Metode penelitian yang digunakan adalah penelitian korelasional, dengan subjek penelitian ini di wilayah Jakarta Selatan dengan sampel 120 anak. Penelitian dilakukan dengan teknik pengumpulan data melalui teknik survey dengan bantuan kuisioner. Penguasaan kosakata anak mencangkup kosakata (1) aktif-produktif yaitu menggunakan kata, dan (2) pasif-reseptif yaitu memahami makna kata. Persepsi terhadap Dukungan Orangtua adalah pandangan anak pada bantuan atau dukungan sosial yang diberikan orangtua kepada anak, meliputi (1) dukungan emosional, (2) dukungan informational, (3) instrumental.Teknik analisis data dalam penelitan ini adalah analisis data kuantitatif. Hasil Menunjukkan bahwa terdapat hubungan signifikan antara persepsi dukungan orangtua dengan penguasaan kosakata dengan nilai koefisien determinasi 71%, Hasil tersebut memberikan implikasi bahwa terdapat hubungan persepsi dukungan orangtua terhadap penguasaan kosakata.
BAGAIMANA KUALITAS KEHIDUPAN KERJA BERPENGARUH TERHADAP MOTIVASI KERJA KARYAWAN
Authors: Goh Jennifer , Sihombing Sriwindany , Zebua Yufan , Rosemaria Gissele , Khairany Tengku , Hartini Sri 
Published: January 2022

Abstrak---Penelitian ini memiliki tujuan agar dapat mencari tahu ada tidaknya hubungan antara kualitas kehidupan kerja dan motivasi kerja pada karyawan PT. Clipan Finance Indonesia Tbk. Medan, Sumatera Utara. Hipotesis yang diajukan ialah adanya hubungan positif antara kualitas kehidupan kerja dan motivasi kerja pada karyawan PT. Clipan Finance Indonesia Tbk. Populasi pada penelitian ini berjumlah 127 karyawan. Sampel penelitian adalah 109 orang. Penelitian ini menggunakan teknik sampling Purposive Sampling. Metode yang digunakan adalah metode kuantitatif. Data penelitian dikumpulkan menggunakan skala kualitas kehidupan kerja dengan 44 butir aitem dan skala motivasi kerja dengan 26 butir aitem. Data yang berhasil dikumpulkan kemudian dilakukan uji asumsi yang terdiri dari uji normalitas dan linearitas. Setelah memenuhi syarat kemudian dilakukan analisis korelasi Product Moment yang dibantu dengan program SPSS 21 untuk Windows. Hasil penelitian yang diperoleh adalah terdapat hubungan positif antara variabel kualitas kehidupan kerja dan motivasi kerja pada karyawan PT. Clipan Finance Indonesia, Tbk. Nilai korelasi Product Moment yang diperoleh adalah r = 0,684 dengan sig. 0,000 (p < 0,05). Nilai sumbangan efektif variabel kualitas kehidupan kerja terhadap motivasi kerja adalah 46,8 persen, sisanya 53,2 persen dipengaruhi hal-hal lain yang tidak diteliti.

Abstract---This study aims to find out whether there is a relationship between the quality of life and work motivation of the employees of PT. Clipan Finance Indonesia Tbk. Medan, North Sumatra. The hypothesis proposed that there is a positive relationship between the quality of work life and work motivation of employees of PT. Clipan Finance Indonesia Tbk. The population in this study are 127 employees. The sample used was 109 people. The sampling technique used was purposive sampling. The method used is a quantitative method. The research data were collected using a quality of life scale with 44 items and a work motivation scale with 26 items. The data collected was then performed an assumption test consisting of normality and linearity tests. After fulfilling the requirements, a Product Moment analysis is carried out with the help of the SPSS 21 program for Windows. The results obtained are that there is a positive relationship between the variables of the quality of work life and work motivation of the employees of PT. Clipan Finance Indonesia, Tbk. The product moment value obtained is r = 0,684 with sig. 0.000 (p <0.05). The value of the effective contribution of the quality of work life variable to work motivation is 46,8 percent, the remaining 53,2 percent was inflluenced by other things that are not examined.
STUDI KEMAMPUAN EKSTRAK ETANOL UMBI BAWANG LANANG HITAM (Allium sativum L.) SEBAGAI ANTIDIABETES
Authors: Wisnu Kusuma Eka , Ingrid Anggraini Devina , Putri Pancawati Desty 
Published: January 2022

Diabetes melitus salah satu penyakit komorbid yang paling beresiko dan memperburuk orang yang terinfeksi COVID-19. Kontrol gula darah sangat penting untuk menjaga sistem imun tubuh. Pengobatan bahan alam untuk antidiabetes lebih digemari masyarakat. Penelitian ini dilakukan untuk mengetahui kemampuan ekstrak etanol umbi bawang lanang hitam (Allium sativum L.) dalam menurunkan kadar glukosa sebesar 50 %. Ekstrak umbi bawang lanang hitam (Allium sativum L.) diperoleh dengan maserasi menggunakan etanol 70%. Skrining fitokimia menunjukkan bahwa umbi bawang lanang hitam mengandung senyawa flavonoid, polifenol dan saponin. Uji aktivitas anti diabetes dengan reagen Nelson-Somogy dianalisis menggunakan Spektrofotometer UV-Vis dengan operating time selama 25 menit dan panjang gelombang maksimum 746 nm. Pengukuran penurunan kadar glukosa dilakukan dengan lima variasi konsentrasi yaitu 1 ppm, 2 ppm, 3 ppm, 4 ppm dan 5 ppm. Hasil penelitian menunjukkan ekstrak etanol umbi bawang lanang hitam (Allium sativum L.) memiliki kemampuan menurunkan kadar glukosa sangat kuat dengan nilai EC50 3,8790 ppm dan %KV sebesar 0,6368%.
Diabetes melitus is one of the riskiest comorbid diseases and worsens the infected person COVID-19. Blood sugar control is very important to maintain the body's immune system. Natural medicine for anti-diabetes is more popular with the public.This research was conducted to determine the ethanol extract of black lanang onion tubers (Allium sativum L.) has the ability to reduce glucose levels by 50%.Black lanang onion tubers (Allium sativum L.) macerated with 70% ethanol. The results showed that black lanang onion tubers contained flavonoids, polyphenols and saponins. The study of antidiabetic activity used the Nelson-Somogy method using a UV-Vis spectrophotometer instrument with operating time after heating for 25 minutes and a wavelength of 746 nm. Measurement of the decrease in glucose levels using five concentrations of 1 ppm, 2 ppm, 3 ppm, 4 ppm, 5 ppm. The results showed ethanol extract of black lanang onion tubers (Allium sativum L.) has a very strong ability to reduce glucose levels with an EC value of 3.8790 ppm and %KV of 0.6368%.
Chirality-controlled enantiopure crystal growth of a transition metal monosilicide by a floating zone method
Authors: Kousaka Yusuke , Iwasaki Satoshi , Sayo Taisei , Tanida Hiroshi , Matsumura Takeshi , Araki Shingo , Akimitsu Jun , Togawa Yoshihiko 
Published: January 2022

Abstract
We performed a crystal growth to obtain chirality-controlled enantiopure crystals using a laser-diode-heated floating zone (LDFZ) method with a composition-gradient feed rod. It has been argued that the crystal handedness of TSi (T : transition metal) is fixed depending on T in the case of the ones grown by the conventional methods. We found that right-handed single crystals of CoSi and MnSi were grown from the composition-gradient feed rods that consist of FeSi–CoSi and FeSi–MnSi, respectively. The obtained CoSi and MnSi crystals inherit the chirality from the seed part of FeSi, which grows in a right-handed structure, and thus has the chirality opposite to that for the crystals in the literature. The LDFZ method with the feed rods with various combinations of TSi compounds enables flexible control of the chirality of TSi and will be useful for clarifying the interplay between crystalline chirality and chirality-induced physical responses.
Optical properties of copper naphthalocyanine nanoparticles prepared by laser ablation in liquid
Authors: Omura Keita , Kitamoto Yoshitaka , Hara Masahiko , Wada Hiroyuki 
Published: January 2022

Abstract
Copper naphthalocyanine nanoparticles were successfully prepared by laser ablation in liquid. Micron-size copper naphthalocyanine powders were used as the raw material in water and were irradiated with a laser beam (Nd:YAG, SHG) to obtain nanoparticles. Nanoparticles were examined by scanning electron microscopy, dynamic light scattering, a spectrophotometer, and Raman spectroscopy. Even in the case of irradiation at low laser fluence and for short irradiation times, nanoparticles were obtained owing to the comparatively low threshold of laser ablation. Laser irradiation changed the crystal structure, but the composition of the nanoparticles was not altered by laser irradiation. The dispersion stability of nanoparticle solution was very high, and absorbance of the solution was almost constant without precipitation. The conversion rate from raw material to nanoparticle was 85.5%. The Grüneisen coefficient for the copper naphthalocyanine nanoparticles was also high; therefore, the produced copper naphthalocyanine nanoparticles were suitable as a contrast agent for photoacoustic imaging.
Structural manipulation for solid electrolyte Na3OBr by sulfur ions doping
Authors: Asakawa Hiroaki , Shi Wei , Murayama Mariko , Zhao Xinwei 
Published: January 2022

Abstract
The ionic conductivity of a solid electrolyte for sodium-ion batteries is a hot topic nowadays. The lattice distortion introduced into the solid electrolyte produces high ionic conductivity. We attempted to introduce lattice distortion into Na3OBr, a solid electrolyte for the sodium-ion batteries, by synthesizing Na3O1−a
S
a
Br in which the oxygen ions are partially replaced by sulfur ions. The solid electrolyte Na3OBr has anti-perovskite structure, which makes it easy to manipulate the crystal structure. We have succeeded in synthesizing high purity Na3O1−a
S
a
Br

a
=
0
,
0.05
,
0.1
,
0.15
,
0.2

.

The lattice distortions have been introduced to Na3OBr.