bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation Education in a Modern Multidisciplinary Clinical Medical Center
Authors: Абельская И.С. , Каминская Т.В. , Борушко О.С. 
Published: February 2022

Публикация посвящена опыту организации и применения симуляционного обучения в медицине на базе высокотехнологичного многопрофильного клинического медицинского центра. Авторами отмечены современные подходы и темпы развития технологий в медицине, требующие от медицинского персонала быстрого и качественного приобретения мануальных навыков и развития клинического мышления с минимизацией лечебно-диагностических ошибок и безопасности для пациента. Подробно описана структура, оснащение симуляционного центра, реализуемые образовательные программы повышения квалификации и обучающих курсов, в том числе эксклюзивные, не имеющие аналогов в Республике Беларусь. Представленная модель образовательного симуляционного центра в высокотехнологичной, многопрофильной клинике позволяет признать ее эффективной и использовать при реализации программы модернизации системы здравоохранения и трансформирования постдипломного образования в Республике Беларусь.
The publication is devoted to the experience of organizing and applying the simulation training in medicine on the base of modern multidisciplinary clinical medical center. The authors distinguished modern approaches and rates of development of technologies in medicine, which requires medical personnel to acquire manual skills quickly and efficiently and develop clinical thinking with minimization of treatment and diagnostic errors providing safety for the patient. The structure is described in detail: equipment of the simulation center, educational programs for advanced training and training courses, including exclusive ones that have no analogues in the Republic of Belarus. The presented model of the educational simulation center in a modern multidisciplinary clinic allows us to recognize its efficiency and to use it in the implementation of the program of modernization of the healthcare system and transformation of postgraduate education in the Republic of Belarus.
Features of Skin Pathology in Liver Transplant Recipients
Authors: Музыченко А.П. , Руммо О.О. 
Published: February 2022

Пациенты, перенесшие трансплантацию печени, подвержены высокому риску развития дерматологических осложнений по сравнению с общей популяцией в результате продолжительной иммуносупрессивной терапии. Ранняя диагностика и соответствующее лечение кожной патологии - важная составляющая клинического ведения реципиентов печеночного трансплантата.
Patients undergoing liver transplantation are at a high risk of dermatological complications compared to the general population as a result of long-term use of immunosuppressant. Their early recognition and appropriate treatment is an important component of the clinical management of liver transplant recipients.
Possibilities and Prospects for Using Calcipotriol in Dermatological Practice for Local Treatment of Psoriasis
Authors: Панкратов О.В. 
Published: February 2022

Приведены данные о патогенезе псориаза и возможных направлениях его наружного лечения. Проведен анализ современного международного опыта использования кальципотриола - синтетического аналога 1,25-дигидрооксихолекальциферола - наиболее активного метаболита витамина D3 для местного лечения пациентов с вульгарным псориазом. Обсуждены возможности применения лекарственных средств кальципотриола в виде раствора, мази, а также комбинации кальципотриола и бетаметазона при местном лечении вульгарного псориаза. Предложено более широкое использование лекарственных средств на основе кальципотриола для местного лечения пациентов с вульгарным псориазом как в виде монотерапии, так и в комбинации с бетаметазоном, что позволит обеспечить высокую эффективность и безопасность терапии, повысить качество жизни пациентов, комплаентность лечения с более благоприятными фармакоэкономическими показателями.
The data on the pathogenesis of psoriasis and possible directions of its external treatment are presented. The analysis of modern international experience of using calcipotriol - a synthetic analogue of 1.25-dihydrooxycholecalciferol - the most active metabolite of vitamin D3 for local treatment of patients with psoriasis vulgaris was carried out. The possibilities of using calcipotriol drugs in the form of a solution, ointment, as well as a combination of calcipotriol and betamethasone in the local treatment of psoriasis vulgaris are discussed. A wider use of drugs based on calcipotriol for local treatment of patients with psoriasis vulgaris, both in the form of monotherapy and in combination with betamethasone, has been proposed, which will ensure high efficacy and safety of therapy, improve the quality of life of patients, and treatment compliance with more favorable pharmacoeconomic indicators.
Myelodysplastic Syndrome on the Background of Severe Hypothyroidism: Case Report and Literature Review
Authors: Песоцкая Л.А. , Щукина Е.С. , Опрятная Т.О. 
Published: February 2022

Миелодиспластический синдром (МДС) - гетерогенная группа клональных заболеваний системы крови, возникающих вследствие мутации гемопоэтической стволовой клетки и характеризующихся цитопенией, как результатом неэффективного гемопоэза, признаками дисмиелопоэза и высоким риском трансформации в острый лейкоз. Более 80% пациентов c МДС - это люди старше 60 лет. В целом в Европе ежегодно диагностируют примерно 25 тыс. новых случаев. Учитывая неуклонное «старение» населения Европы, полагают, что число пациентов с МДС будет в ближайшие десятилетия лишь возрастать. Кроме того, признаки миелодисплазии могут выявляться в костном мозге или периферической крови не только при МДС, но и при других заболеваниях неклонального характера. Известна роль в гемопоэзе гормонов щитовидной железы, что не исключает развития дисмиелопоэза при гипотиреозе. Встатье приводятся классификация, клиника первичного МДС и клинический случай развития заболевания на фоне тяжелого гипотиреоза с особенностями течения МДС.
Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal diseases of the blood system arising from mutation of the hematopoietic stem cell and characterized by cytopenia as a result of ineffective hematopoiesis, the signs of dysmyelopoiesis, and a high risk of transformation into acute leukemia. More than 80% of MDS patients are over 60 years old. Approximately 25,000 new cases are diagnosed annually in Europe. Taking into account the aging of the European population, it is believed that the number of patients with MDS will only increase in the coming decades. Additionally, the signs of myelodysplasia can be detected in the bone marrow or peripheral blood, not only in MDS, but also in other non-clonal diseases. The role of thyroid hormones in hematopoiesis is known, which does not exclude the development of dysmyelopoiesis in hypothyroidism. The article presents the classification, the clinic of primary MDS, and the clinical case of the development of disease on the background of severe hypothyroidism with the features of the course of MDS.
The Role of Genetic Disorders of the RB1 Gene in the Pathogenesis of Retinoblastoma
Authors: Гурьянова И.Е. , Макаревич О.О. , Литвинова Д.Ю. , Мигас А.А. , Конопля Н.Е. 
Published: February 2022

Введение. Ретинобластома - это злокачественная внутриглазная нейроэктодермальная опухоль (внутренней оболочки глаза), чаще поражающая детей в возрасте от 0 до 9 лет. 90% случаев диагностируются в возрасте до 5 лет, из них две трети - в возрасте до 2 лет. Ретинобластома представлена двумя различными клиническими формами: наследственной формой (40% случаев), при которой опухоли двусторонние и мультифокальные, проявляющиеся вболее раннем возрасте; и ненаследственной формой (60% случаев), при которой опухоли односторонние и унифокальные, проявляющиеся в более позднем возрасте. Этиология формирования ретинобластомы обусловлена возникновением мутаций в онкосупрессорном гене RB1. Ген RB1 кодирует ядерный фосфопротеин pRb, который играет важную роль в регуляции клеточного цикла. Целью написания данной статьи было повышение осведомленности о клинической картине ретинобластомы и обоснование важности внедрения молекулярно-генетического исследования гена RB1 в диагностический процесс. Заключение. Своевременная клиническая диагностика позволяет раньше начать лечение, снизить риск развития тяжелого течения заболевания и сохранить глазное яблоко и зрительные функции пациентов с ретинобластомой. Молекулярная диагностика генетических нарушений гена RB1 помогает дифференцировать врожденную и соматическую формы ретинобластомы, дает возможность пациентам и их кровным родственникам принимать информированные решения в области планирования семьи, проводить прогностическую оценку в семьях с низкой пенетрантностью.
Introduction. Retinoblastoma is a malignant intraocular neuroectodermal tumor (inner lining of the eye) that most commonly affects children aged from 0 to 9 years. Two-thirds of cases are diagnosed before the age of 2 years, and 90% of cases are diagnosed before the age of 5 years. Retinoblastoma presents in two distinct clinical forms: a heritable form (40% of cases), in which tumors are bilateral and multifocal, presenting at an earlier age; a non-heritable form (60% of cases), in which tumors are unilateral and unifocal, presenting at a later age. The etiology of retinoblastoma formation is caused by the occurrence of mutations in the tumor suppressor gene (RB1). The RB1 gene encodes a nuclear phosphoprotein (pRB) that is found in a mutated form in a wide range of human tumors. Purpose. To raise awareness of the clinical picture of retinoblastoma and demonstrate the importance of including molecular genetic analysis into the diagnostic process. Conclusion. Timely clinical diagnostics lets to conduct early treatment, reduces the risk of development of severe course of disease, and improves eyeball condition in patients with retinoblastoma. Genetic diagnostics helps to distinguish hereditary and somatic forms of retinoblastoma, enables patients and their relatives to make informed reproductive choices regarding subsequent pregnancies and to conduct prognostic assessment in families with low penetrance.
Propuesta de contenidos en plan de capacitación administrativa para emprendimientos en Quito
Authors: Arias Ronquillo Carlos José , Jaramillo Bayas Carolina Paola , Muquis Tituaña Lorena Elizabeth 
Published: February 2022

La academia, dentro del entono de vinculación con la sociedad, se ve cada vez más enlazada con establecer formas de apoyo a los sectores vulnerables. En este caso se trata de los emprendedores del Distrito Metropolitano de Quito, pues la actividad empresarial presenta problemas al iniciar el negocio y luego al comercializar sus productos. Existe incertidumbre, porque en los emprendimientos, las necesidades económicas que se presentan ayudan a tomar decisiones erróneas sobre el manejo de su negocio, ya que el escaso conocimiento en algunos temas administrativos y comerciales puede llevar al declive del emprendedor.
El presente trabajo de investigación plantea como objetivo diseñar una malla curricular con contenidos temáticos, requeridos por los emprendedores en el área administrativa y comercial, dentro de un plan de capacitación, para lo cual se aplicó una metodología cuantitativa, basada en el criterio de expertos de instituciones involucradas en procesos de capacitación a emprendedores, así como con base en los resultados de investigaciones previas realizadas dentro de la propia universidad, y de cuyos resultados se pudo establecer las áreas temáticas administrativa, comercial y financiera contable, cuyos principales contenidos se organizaron en tres niveles en un plan de capacitaciones para emprendimientos, establecidos en el presente estudio.
Pencegahan Fraud Dalam Pelaporan Keuangan: Pendekatan Faktor Individu
Authors: Rosari Renya , Zacharias Jems , Pono Mefibosed Radjah 
Published: February 2022

This study aims to find empirical evidence of the effect of morality, integrity and religiosity on fraud prevention in regional financial management. This research is an explanatory research, the approach used in this research is survey method. The population of this study were all employees at BPKAD Kota and Kabupaten Kupang. The sample in this study were 46 respondents of BPKD employees in the accounting and reporting divisions and regional assets. The data analysis technique used PLS Regression (Partial Last Square) path analysis using SmartPLS 3.0 software. This test is carried out in 3 stages, namely evaluating the outer model, 2) inner model, and Â 3) Hypothesis testing. The results of the study show that morality has an effect on fraud prevention, religiosity and integrity have no effect on fraud prevention in regional financial management.
Visualization of depletion layer in AlGaN homojunction p–n junction
Authors: Nagata Kengo , Anada Satoshi , Saito Yoshiki , Kushimoto Maki , Honda Yoshio , Takeuchi Tetsuya , Yamamoto Kazuo , Hirayama Tsukasa , Amano Hiroshi 
Published: February 2022

Abstract
We analyzed the p–n junction of an aluminum gallium nitride (AlGaN) homojunction tunnel junction (TJ) deep-ultraviolet light-emitting diode by phase-shifting electron holography. We clearly obtained a phase image reflecting the band alinement of the p–n homojunction and derived a depletion layer width of approximately 10 nm. In addition, the observed depletion layer width for the AlGaN TJ was in good agreement with the simulated one reflecting the diffusion profile of Mg and Si, thus enabling a discussion on the electrical conduction mechanism for an AlGaN p–n junction.
Il voto differenziale nelle elezioni per la Camera dei Deputati del 1996 e del 2001 - Una analisi descrittiva e casuale
Authors: Venturino Fulvio 
Published: February 2022

Una forma di voto sofisticato.
Coalizioni elettorali e voto differenziato in Italia, 1996 e 2001.
Gradimento dei candidati premier e voto differenziato.
Collocazione spaziale e voto differenziato.
Candidati premier e collocazione spaziale: che cosa conta di più?
Conclusioni.
La transizione nella Russia postcomunista: il ciclo elettorale 1993-1999
Authors: Morini Mara 
Published: February 2022

Le elezioni sovietiche del 1989.
Dalla dissoluzione del PCUS alla nascita della Federazione Russa.
Sistema elettorale e legislazione di contorno.
L'offerta politica e i risultati delle elezioni del 12 dicembre 1993.
Gli avvenimenti politici nel biennio 1993-1995 e la riforma elettorale.
Le elezioni politiche del 17 dicembre 1995.
Le elezioni politiche del 1999: strategie e risultati.
La strutturazione del voto nella Russia postcomunista: alcune considerazioni conclusive.
La Toscana è ancora una regione rossa? Note e riflessioni sulle elezioni regionali del 16 aprile 2000
Authors: Floridia Antonio 
Published: February 2022

In questo lavoro presenteremo alcune elaborazioni e riflessioni sulle elezioni regionali toscane del 16 aprile 2000, muovendo da un duplice punto di vista: da una parte, cercheremo di mettere a fuoco alcuni aspetti legati alle trasformazioni del sistema politico regionale, ai mutamenti istituzionali, agli effetti indotti dalle nuove regole elettorali. Dall’altra parte, guarderemo ai risultati elettorali e ne analizzeremo in particolare la dimensione territoriale, prospettando infine alcune ipotesi sulle possibili connessioni tra la geografia del voto e le caratteristiche sociali ed economiche dei diversi sistemi locali della Toscana.
L'elettorato austriaco e l'ascesa di Jörg Haider
Authors: Pallaver Günther 
Published: February 2022

La "deaustrificazione" dell'Austria.
Il sistema elettorale.
La trasformazione del sistema partitico.
Il comportamento elettorale.
I mutamenti nella composizione sociale degli elettorati dei vari partiti.
Il terzo polo: i liberali dalla Prima Repubblica al 1986.
Il populismo di Haider e l'impetuosa crescita della FPÖ.
L'elettorato della FPÖ: le sue motivazioni e le sue caratteristiche.
Guardando al futuro.
Fra elezioni regionali e elezioni politiche: l'interludio amministrativo e referendario del 2000
Authors: Di Virgilio Aldo 
Published: February 2022

Assieme alle elezioni regionali – l’evento elettorale più importante dell’anno sul quale si rimanda al precedente numero dei Quaderni - il 16 aprile 2000 si sono svolte 6 elezioni provinciali e 490 elezioni comunali (79 in comuni con oltre 15.000 abitanti, fra i quali 10 capoluoghi di provincia; 471 in comuni minori). In cinque delle sei province e in 53 dei 79 comuni con oltre 15.000 abitanti (fra i quali 9 comuni capoluogo di provincia) si è tornati alle urne due settimane più tardi per eleggere al ballottaggio presidenti di provincia e sindaci.
Il 21 maggio l’intero corpo elettorale è stato invece convocato per rispondere con un “Sì” o con un “No” a sette quesiti abrogativi relativi a temi di carattere elettorale (rimborso spese elettorali; sistema elettorale per la Camera; sistema elettorale per il Consiglio Superiore della Magistratura), giudiziario (ordinamento giudiziario; incarichi extragiudiziari dei magistrati) e giuslavoristico (disciplina dei licenziamenti; trattenute associative e sindacali tramite gli enti previdenziali).
Altre tornate di voto, più circoscritte per numero di unità amministrative e ambito territoriale, si sono svolte in maggio e in novembre. Il 7 maggio si è votato nei 68 comuni valdostani, capoluogo compreso; il 14 maggio in 321 comuni trentini ed alto-atesini, tra i quali Bolzano; il 12 novembre in 4 piccoli comuni trentini; il 26 novembre in 19 comuni siciliani, tra i quali Enna.
Una città e due elettorati. Il voto a Lecce nel 1999 e nel 2000
Authors: Giaffreda Marco 
Published: February 2022

Il voto a Lecce dal 1946 al 1996.
Dopo il 1993: il centro ancora arbitro.
Un affollato giugno elettorale.
L'analisi del voto: tra personalizzazione e astensionismo.
Il voto regionale del 2000: l'esaltante primavera di Forza Italia.
Conclusioni.
STRATEGI KESANTUNAN BERBAHASA DALAM TALK SHOW Q&A DAN RELEVANSINYA TERHADAP PEMBELAJARAN BAHASA INDONESIA TINGKAT SMP
Authors: Tri Indrayanti  
Published: February 2022

Abstract
The purpose of this study to describe the politeness strategies of Brown and Levinson in the Q&A talk show and describe the relevance of politeness-language strategies towards learning Indonesian at the Middle School level. The theory used to solve the problem in this study is the theory of Brown and Levinson. While the approach used is descriptive qualitative approach with data collection techniques namely documentation techniques. The results of this study indicate that the forms of Brown and Levinson's politeness strategy that occurred in the Q & A talk show in August 2018 consisted of Brown and Levinson's first politeness strategy, namely without strategies found that included speech without strategy. The second strategy of brown politeness and Levinson's positive politeness strategy is found to pay attention to the opponent's speech, exaggerate attention, agreement, and sympathy, intensify the opponent's attention by dramatizing facts, intensify using group identity markers, request approval with general topics or repeat part or all, avoiding disagreement by pretending to agree, using jokes, expressing understanding of the wishes of speakers, giving offers or promises, showing optimism, involving speakers in activities, giving questions asking for approval, giving gifts. Where negative politeness strategies are found to be pessimistic, minimize coercion, and apologize. Finally, the Off Record strategy was found which was included in the strategy. The relevance of the results of the study can be applied in learning Indonesian in junior high school class IX 3.9-4.10.
KARAKTERISTIK PUISI KARYA-KARYA W.S RENDRA
Authors: Mariam Ulfa  , Fatmawati Fatmawati , Fatmasari Ria Kristia 
Published: February 2022

Puisi memiliki karakteristik yang berbeda satu sama lain, adanya sebuah karakteristik dikarenakan ada faktor pembeda. Karakteristik puisi adalah ciri khas yang terdapat didalam puisi. Karakteristik puisi memiliki peranan penting dalam suatu pembelajaran, biasanya menggunakan bahasa yang singkat dan dirangkai dalam bentuk bait-bait serta memiliki sifat sesuai dengan kenyataan sebuah puisi.
Tujuan penelitian ini untuk (1) mendeskripsikan cinta libidinal dalam kumpulan puisi karya-karya W.S Rendra (2) mendeskripsikan cinta humanisme dalam kumpulan puisi karya-karya W.S Rendra (3) mendeskripsikan cinta sufisme dalam kumpulan puisi karya-karya W.S Rendra. Penelitian ini menggunakan metode kualitatif deskriptif. sember data penelitian adalah menggunakan tiga buku puisi karya-karya W.S Rendra yang buku pertama berjudul Doa Untuk Anak Cucu diambil 20 data dari 61 puisi. Judul buku kedua Stanza dan Blues diambil 20 data dari 81 puisi dan buku ketiga berjudul Puisi-Puisi Cinta diambil 20 data dari 68 puisi. Pengumpulan data dilakukan dengan cara mencari data mengenai hal-hal yang berkaitan dengan fokus kajian permasalahan. Hasil penelitian ini menunjukkan bahwa karakteristik puisi karya-karya W.S Rendra memiliki karakteristik tersendiri seperti cinta libidinal membahas tentang suatu kecintaannya terhadap kekasih yang saling mencintai satu sama lain, cinta humanisme membahas tentang suatu kecintaanhya terhadap sesama manusia atau sosial kemasyarakatan dan cinta sufisme membahas tentang suatu kecintaannya terhadap sebuah agama.
P PELATIHAN PEMBUKUAN DAN PEMASARAN ONLINE UMKM MAKANAN DAN MINUMAN MANGGARSARI KECAMATAN TAMBAKSARI KOTA SURABAYA
Authors: Susanti Susanti 
Published: February 2022

Usaha Mikro Kecil Menengah (UMKM) mempunyai potensi yang masih dapat dikembangkan, baik dalam produktivitas maupun daya saing. Selain itu UMKM juga sangat bermanfaat bagi pelaku usaha karena dapat meningkatkan kemakmuran hidupnya. Dalam prosesnya, ada beberapa UMKM MANGGARSARI yang memproduksi makanan dan minuman di Kecamatan Tambak Sari Kota Surabaya yang dapat berkembang dan kemudian menjadi sukses, namun tak sedikit yang mengalami hambatan. Faktor pendukung dan penghambat yang ada di UMKM MANGGARSARI dipengaruhi oleh beberapa faktor diantaranya masalah pemasaran dan teknologi, ketangguhan pelaku usaha, korespondensi, harga dan kualitas produk, kemasan/packaging serta modal. Oleh karena itu, pada bidang pembukuan sederhana tim melakukan pelatihan dalam menyusun laporan keuangan minimal laporan aliran kas dan penyusunan laporan produksi. Di bidang pemasaran tim memberikan pelatihan pemasaran on line dan membuat e-poster sebagai sarana untuk mendukung berjalannya pemasaran online tersebut. Pelaku usaha di UMKM MANGGARSARI diharapkan tetap tangguh dalam menjalani usahanya mengikuti perkembangan jaman serta dapat menyusun laporan keuangan dan menentukan harga jual produknya sesuai dengan biaya. Hal tersebut dapat menjaga memperkuat pelaku usaha UMKM Manggarsari dalam menjalakan kegiatan operasional usahanya.
Kata Kunci: pembukuan sederhana, Laporan Biaya Produksi, Pemasaran on-line, flyer
Micro, Small and Medium Enterprises (MSMEs) have potential that can still be developed, both in terms of productivity and competitiveness. In addition, MSMEs are also very useful for business actors because they can increase their prosperity. In the process, there are several MANGGARSARI MSMEs that produce food and beverages in Tambak Sari District, Surabaya City which can develop and then become successful, but not a few have encountered obstacles. The supporting and inhibiting factors in MANGGARSARI MSMEs are influenced by several factors including marketing and technology problems, business actor resilience, correspondence, product price and quality, packaging/packaging and capital. Therefore, in the field of simple bookkeeping, the team conducts training in preparing financial reports, at least cash flow reports and preparing production reports. In the field of marketing, the team provides online marketing training and makes e-posters as a means to support the online marketing. Business actors in MANGGARSARI MSMEs are expected to remain strong in carrying out their business to keep up with the times and be able to compile financial reports and determine the selling price of their products according to cost. This can maintain strengthening the Manggarsari MSME business actors in carrying out their business operations.
Keywords: simple bookkeeping, Production Cost Report, on-line marketing, flyer