bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbes, Histology, Blood Analysis, Enterotoxins, and Cytokines: Findings From the ASERF Systemic Symptoms in Women–Biospecimen Analysis Study: Part 3
Authors: McGuire Patricia , Glicksman Caroline , Wixtrom Roger , Sung C James , Hamilton Robert , Lawrence Marisa , Haws Melinda , Ferenz Sarah , Kadin Marshall 
Published: August 2022

AbstractBackgroundThere has been an increasing need to acquire rigorous scientific data to answer the concerns of physicians, patients, and the FDA regarding the self-reported illness identified as breast implant illness (BII). There are no diagnostic tests or specific laboratory values to explain the reported systemic symptoms described by these patients.ObjectivesThe aim of this study was to determine if there are quantifiable laboratory findings that can be identified in blood, capsule tissue pathology, or microbes that differentiate women with systemic symptoms they attribute to their implants from 2 control groups.MethodsA prospective blinded study enrolled 150 subjects into 3 cohorts: (A) women with systemic symptoms they attribute to implants who requested implant removal; (B) women with breast implants requesting removal or exchange who did not have symptoms attributed to implants; and (C) women undergoing cosmetic mastopexy who have never had any implanted medical device. Capsule tissue underwent detailed analysis and blood was sent from all 3 cohorts to evaluate for markers of inflammation.ResultsNo significant histologic differences were identified between the cohorts, except there were more capsules with synovial metaplasia in the non-BII cohort. There was no statistical difference in thyroid-stimulating hormone, vitamin D levels, or complete blood count with differential between the cohorts. Next-generation sequencing revealed no statistically significant difference in positivity between Cohort A and B. Of the 12 cytokines measured, 3 cytokines, interleukin (IL)-17A, IL-13, and IL-22, were found to be significantly more often elevated in sera of subjects in Cohort A than in Cohorts B or C. The enterotoxin data demonstrated an elevation in immunoglobulin G (IgG) anti–Staphylococcus aureus enterotoxin A in Cohort A. There was no correlation between the presence of IgE or IgG anti-Staphylococcal antibody and a positive next-generation sequencing result.ConclusionsThis study adds to the current literature by demonstrating few identifiable biomedical markers to explain the systemic symptoms self-reported by patients with BII.
Fat Juice: A Novel Approach on the Usage and Preparation of Adipose Tissue By-Products
Authors: Cihantimur Bulent , Moret Gina , Ünal Gökhan 
Published: August 2022

AbstractBackgroundAdipose tissue is considered to be naturally rich in a range of bioactive substances that may be extracted directly for therapeutic use without the need for cell isolation or cultureObjectivesThe aim of this study was to introduce a novel approach that utilizes stromal vascular fraction in conjunction with fat extract, termed “fat juice,” and to perform a comprehensive biochemical analysis in relation to the potential clinical relevance of this new combination.MethodsA total of 11 samples of fat juice from the abdominal lipoaspirate were extracted from 11 healthy patients and analyzed in terms of the quantity and viability of stem cells, the presence and quantification of connective tissue fibers on histopathologic examination, and the levels of interleukin-6, mannose receptor C type 1, and vascular endothelial growth factor measured by enzyme-linked immunosorbent assay.ResultsTotal stem cell amounts ranged from 0.14 × 105 to 1.31 × 105, and cell viability rates varied between 20% and 67.9%. Interleukin-6 protein and vascular endothelial growth factor expressions were highest in Sample 3, while staining intensity was highest in Sample 4. For collagen I, collagen III, and elastin, the highest expressions were observed in Samples 4 and 8, in Sample 3, and in Samples 2 and 4, respectively.ConclusionsFat juice provides an easy-to-inject concentration of adipocyte/preadipocytes, red blood cells, adipose-derived stem cells, endothelial-derived cells, and cell residues. Prepared through an easy isolation process enabling abundant availability, fat juice seems to be an effective skin quality enhancer with potential for widespread use in the fields of plastic surgery, dermatology, and aesthetic/regenerative medicine.
Mosaic adaptive peak shifts underlie body shape diversification in pelagiarian fishes (Acanthomorpha: Percomorpha)
Authors: Collar David C , Tremaine Samantha , Harrington Richard C , Beckett Hermione T , Friedman Matt 
Published: August 2022

Abstract
Extreme body elongation in fishes is a major evolutionary transformation that extends the boundaries of morphological diversity and alters aspects of function, behaviour and ecology. Prior studies have identified features of the cranial and axial skeleton that characterize elongate fishes, but a lack of detailed reconstructions of anatomical evolution has limited inferences about factors that underlie major shifts in body shape. In this study, we fitted multi-peak adaptive (Ornstein–Uhlenbeck) evolutionary models to species body shape and anatomical dimensions in Pelagiaria, a radiation of open-ocean fishes whose species span a continuum from deep bodied to highly elongate. We inferred an ancestral fusiform adaptive peak that is retained by several major pelagiarian lineages (e.g. Scombridae) and found robust support for multiple transitions to deep-bodied optima (in the families Stromateidae, Bramidae and Caristiidae) and elongate-bodied optima (within Trichiuroidei), including two instances of sequential shifts towards increasingly elongate optima that followed distinct paths of anatomical evolution. Within Trichiuridae, initial increases in head length and the number of vertebrae were followed by changes in head and vertebral shape. Within an elongate-bodied subclade of taxa traditionally identified as ‘gempylids’, changes in head and vertebral shape and in the number of precaudal vertebrae preceded an increase in the number of caudal vertebrae. Altogether, this mosaic of anatomical peak shifts suggests that body shape transformations were associated with differing selective demands and developmental changes.
Techne and Teleios: A Christian Perspective on the Incarnation and Human Enhancement Technology
Authors: Cole-Turner Ron 
Published: August 2022

Abstract
Does the idea of human enhancement presuppose a goal or an ideal to direct technological modifications? In the absence of such an agreed ideal in today’s culture, can Christian theology help clarify the goal or the meaning of “perfection” when applied to human beings? A theological perspective rooted in scripture and in the writings of theologians such as Irenaeus, Athanasius, and Gregory of Nyssa suggests that theology instead of offering its own definition of the human ideal, theology rejects the possibility of any defined human goal. An analysis of the biblical word teleios (“mature” or “perfect”), along with Gregory’s view of infinite ascent, leads to the conclusion that the human goal is found in relationship to the triune God and not in any anthropologically-definable status.
Investigating cognitive ability using action-based models of structural brain networks
Authors: Arora Viplove , Amico Enrico , Goñi Joaquín , Ventresca Mario 
Published: August 2022

AbstractRecent developments in network neuroscience have highlighted the importance of developing techniques for analysing and modelling brain networks. A particularly powerful approach for studying complex neural systems is to formulate generative models that use wiring rules to synthesize networks closely resembling the topology of a given connectome. Successful models can highlight the principles by which a network is organized (identify structural features that arise from wiring rules versus those that emerge) and potentially uncover the mechanisms by which it grows and develops. Previous research has shown that such models can validate the effectiveness of spatial embedding and other (non-spatial) wiring rules in shaping the network topology of the human connectome. In this research, we propose variants of the action-based model that combine a variety of generative factors capable of explaining the topology of the human connectome. We test the descriptive validity of our models by evaluating their ability to explain between-subject variability. Our analysis provides evidence that geometric constraints are vital for connectivity between brain regions, and an action-based model relying on both topological and geometric properties can account for between-subject variability in structural network properties. Further, we test correlations between parameters of subject-optimized models and various measures of cognitive ability and find that higher cognitive ability is associated with an individual’s tendency to form long-range or non-local connections.
Chromosomal-level genome of velvet bean (Mucuna pruriens) provides resources for L-DOPA synthetic research and development
Authors: Hao Shijie , Ge Qijin , Shao Yunchang , Tang Benqin , Fan Guangyi , Qiu Canyu , Wu Xue , Li Liangwei , Liu Xiaochuan , Shi Chengcheng , Lee Simon Ming-Yuen 
Published: August 2022

AbstractMucuna pruriens, commonly called velvet bean, is the main natural source of levodopa (L-DOPA), which has been marketed as a psychoactive drug for the clinical management of Parkinson’s disease and dopamine-responsive dystonia. Although velvet bean is a very important plant species for food and pharmaceutical manufacturing, the lack of genetic and genomic information about this species severely hinders further molecular research thereon and biotechnological development. Here, we reported the first velvet bean genome, with a size of 500.49 Mb and 11 chromosomes encoding 28,010 proteins. Genomic comparison among legume species indicated that velvet bean speciated ∼29 Ma from soybean clade, without specific genome duplication. Importantly, we identified 21 polyphenol oxidase coding genes that catalyse l-tyrosine to L-DOPA in velvet bean, and two subfamilies showing tandem expansion on Chr3 and Chr7 after speciation. Interestingly, disease-resistant and anti-pathogen gene families were found contracted in velvet bean, which might be related to the expansion of polyphenol oxidase. Our study generated a high-quality genomic reference for velvet bean, an economically important agricultural and medicinal plant, and the newly reported L-DOPA biosynthetic genes could provide indispensable information for the biotechnological and sustainable development of an environment-friendly L-DOPA biosynthesis processing method.
Landscape Composition and Management History Affect Alfalfa Weevil but not its Parasitoid
Authors: Pellissier Makenzie E , Rand Tatyana A , Murphy Melanie A , Jabbour Randa 
Published: August 2022

Abstract
It is widely recognized that both local and landscape-scale factors can be important drivers of crop pests, natural enemies, and biocontrol services. However, recent syntheses have found that landscape effects are inconsistent across study systems, highlighting the need for system-specific research to guide management decisions. In particular, studies conducted in perennial crops and that examine landscape configuration, not just composition, are especially lacking. We studied the impact of local and landscape factors on alfalfa weevil Hypera postica and its parasitoid Bathyplectes curculionis. Although classical biological control efforts have largely suppressed H. postica in the eastern United States, it remains problematic in the western United States. We sampled 20 production alfalfa fields in southeastern Wyoming to estimate H. postica density, parasitism rates by B. curculionis, and vegetation at local scales. We used remotely sensed imagery to characterize both landscape composition and configuration surrounding each sampled field. We used a hypothesis-driven modeling approach to determine which model was most predictive of H. postica and parasitism rate by B. curculionis. Landscape composition was the best model to predict H. postica densities. Host density was the best predictor of parasitism rates by B. curculionis. Production fields that had received insecticide applications in the last 5 years had higher weevil densities than fields that had not received insecticide applications. Stand age was not associated with weevil density or parasitism rate. In conclusion, we found local, landscape, and management components to be important in this system.
Iatrogenic diversion of inferior vena cava to the left atrium presented as recurrent foetal loss: a case report
Authors: Darwazah Ahmad K , Ibrahim Baraa J , Nairat Moath , Khdour Issa , Madi Hamad 
Published: August 2022

Abstract

Background
Iatrogenic diversion of inferior vena cava (IVC) to the left atrium (LA) after atrial septal defect repair (ASD) is an unusual complication. It rarely occurred nowadays due to trans-oesophageal echocardiography (TEE) check during surgery, but there are still few numbers of patients who survived from an old operation during childhood and reached adulthood undiagnosed.

Case summary
We present a 27-year-old female post ASD repair in childhood with a unique presentation of recurrent abortion in adulthood besides exertional dyspnoea. A full workup of investigations was normal except for haemoglobin of 21 and oxygen saturation of 70%. TEE revealed abnormal drainage of IVC to the LA. Surgical correction was done to release the IVC opening to drain in the right atrium and the oxygen saturation reached 99% after weaning from the bypass machine. The postoperative course was uneventful, and the patient was discharged 5 days later. Two years later, she got pregnant twice and completed her pregnancies to term with well-developed infants.

Discussion
The diversion of the IVC may be either complete or partial. Such complications may result in intraoperative death on the table or may present as early desaturation, shortness of breath, cyanosis, and clubbing, or it may present with such symptoms in adulthood. Rarely, it may present with cerebral stroke. Our case presented with the unexpected presentation of recurrent abortion. So, even if it is rare, echocardiography should be considered as a workup for recurrent abortion in a patient with a history of congenital heart surgery.
Recovering individual haplotypes and a contiguous genome assembly from pooled long-read sequencing of the diamondback moth (Lepidoptera: Plutellidae)
Authors: Whiteford Samuel , van’t Hof Arjen E , Krishna Ritesh , Marubbi Thea , Widdison Stephanie , Saccheri Ilik J , Guest Marcus , Morrison Neil I , Darby Alistair C 
Published: August 2022

Abstract
The assembly of divergent haplotypes using noisy long-read data presents a challenge to the reconstruction of haploid genome assemblies, due to overlapping distributions of technical sequencing error, intralocus genetic variation, and interlocus similarity within these data. Here, we present a comparative analysis of assembly algorithms representing overlap-layout-consensus, repeat graph, and de Bruijn graph methods. We examine how postprocessing strategies attempting to reduce redundant heterozygosity interact with the choice of initial assembly algorithm and ultimately produce a series of chromosome-level assemblies for an agricultural pest, the diamondback moth, Plutella xylostella (L.). We compare evaluation methods and show that BUSCO analyses may overestimate haplotig removal processing in long-read draft genomes, in comparison to a k-mer method. We discuss the trade-offs inherent in assembly algorithm and curation choices and suggest that “best practice” is research question dependent. We demonstrate a link between allelic divergence and allele-derived contig redundancy in final genome assemblies and document the patterns of coding and noncoding diversity between redundant sequences. We also document a link between an excess of nonsynonymous polymorphism and haplotigs that are unresolved by assembly or postassembly algorithms. Finally, we discuss how this phenomenon may have relevance for the usage of noisy long-read genome assemblies in comparative genomics.
Health worker motivation to deliver quality care in western Nigeria
Authors: Okafor Ifeoma P , Dada Adebisi A , Olubodun Tope , Olufunlayo Tolulope F 
Published: August 2022

Abstract

Background
Motivation of health service providers (HSPs) is an important factor for delivering quality services and achieving client satisfaction. Understanding the motivation to perform is therefore important in providing evidence for interventions.

Objective
To assess motivation to deliver quality service among antenatal care service providers in public secondary health facilities in western Nigeria.

Method
A cross-sectional, facility-based study was conducted using a validated, semi-structured self-administered questionnaire. In all, 280 HSPs were recruited using multistage sampling method. Data were analyzed using Epi-info statistical software. Inferential statistics such as chi square and binary regression were applied.

Results
Factors with high mean scores as motivators were those related to individual aspects especially conscientiousness, cooperativeness, timeliness and attendance, and appreciation from patients. Factors with the lowest mean scores were those linked with work organization such as limited resources (insufficient staff and equipment) and poor promotion processes. Overall, only 69 (24.5%) of HSPs reported that they were motivated to deliver quality care. Predictors of motivation were nonphysician cadre and longer years of service. Nurse/midwives, lab scientists/lab technicians, and pharmacist/pharmacy technicians were all more likely to be motivated than physicians. HSPs with more than 10 years experience on their current job were almost 9 times more likely to be motivated than those who had spent a lesser duration [odds ratio (OR), 1.14; 95% CI, 1.06–1.22].

Conclusion
HSPs were not motivated to deliver quality care, especially physicians and those who had spent lesser duration on their current job. Interventions should focus on the provision of adequate resources and improving promotion process.
Helicoverpa zea (Lepidoptera: Noctuidae) Thresholds and Yield Compensation Between Soybeans with Determinate and Indeterminate Growth Habits
Authors: Schug Hayden , Reisig Dominic , Huseth Anders , Thrash Ben , Vann Rachel 
Published: August 2022

Abstract
Soybean (Glycine max L.) is an important row crop in the United States and Helicoverpa zea (Boddie) is one of the most serious insect pests in this system. Economic thresholds for H. zea were developed from soybean varieties with determinate growth habits. However, southern USA farmers have recently planted more soybeans varieties with indeterminate growth habits. Trials were conducted with two determinate and two indeterminate varieties within the same relative maturity group. Levels were compared among groups with differing H. zea pressure (low, medium, high, naturally infested) and manipulated using insecticides. Our objectives were to evaluate yield compensation differences among determinate and indeterminate varieties at these different H. zea pressures and to see if the existing economic threshold should be adjusted between growth habits. Since H. zea larval populations varied across trials, we compared trials with low populations, high populations, and no population. Generally, larval counts did not differ among varieties. We found no yield differences among varieties or between growth habits, regardless of H. zea pressure. In the high population tests, yield was highest in the low population plots, but there was no compensation by the plant in yield components except in number of pods with one seed. In contrast, yield components varied widely across varieties, but these differences were independent of H. zea pressure. These results suggest the economic threshold can be used for determinate and indeterminate growth habits, but more research is needed to confirm this with a larger selection of varieties, planting dates, and maturity groups.
Online, computable and punctual structure theory
Authors: Askes Matthew , Downey Rod 
Published: August 2022

Abstract
Several papers (e.g. [7, 23, 42]) have recently sought to give general frameworks for online structures and algorithms ([4]), and seeking to connect, if only by analogy, online and computable structure theory. These initiatives build on earlier work on online colouring and other combinatorial algorithms by Bean [10], Kierstead, Trotter et al. [48, 54, 57] and others, as we discuss below. In this paper we will look at such frameworks and illustrate them with examples from the first author’s MSc Thesis ([58]). In this thesis, Askes looks at online, adversarial online and strongly online algorithms and structures. Additionally, we prove some new theorems about online algorithms on graphs of bounded pathwidth as well as some new results on punctually 1-decidable structures.
Semi-Strong Factors in Asset Returns
Authors: Connor Gregory , Korajczyk Robert A 
Published: August 2022

Abstract
We refine the approximate factor model of asset returns by distinguishing between strong factors, whose sum of squared factor betas grow at the same rate as the number of assets, and semi-strong factors, whose sum of squared factor betas grow to infinity, but at a slower rate. We develop a test statistic for strength of factors based on the cross-sectional mean-square of regression-estimated betas. We also describe an adjusted version of the test statistic to differentiate semi-strong factors from strong factors. We apply the methodology to daily equity returns to characterize some pre-specified factors as strong or semi-strong.
Developmentally Arrested Basket/Stellate Cells in Postnatal Human Brain as Potential Tumor Cells of Origin for Cerebellar Hemangioblastoma in von Hippel-Lindau Patients
Authors: Shively Sharon Baughman , Edwards Nancy A , MacDonald Tobey J , Johnson Kory R , Diaz-Rodriguez Natalia M , Merrill Marsha J , Vortmeyer Alexander O 
Published: August 2022

Abstractvon Hippel-Lindau (VHL) disease is an autosomal dominant hereditary cancer disorder caused by a germline mutation in the VHL tumor suppressor gene. Loss of the wild-type allele results in VHL deficiency and the potential formation of cerebellar hemangioblastomas, which resemble embryonic hemangioblast proliferation and differentiation processes. Multiple, microscopic, VHL-deficient precursors, termed developmentally arrested structural elements (DASEs), consistently involve the cerebellar molecular layer in VHL patients, indicating the tumor site of origin. Unlike hemangioblastomas, however, cerebellar DASEs do not express brachyury, a mesodermal marker for hemangioblasts. In this study, neuronal progenitors occupying the molecular layer were investigated as tumor cells of origin. By immunohistochemistry, cerebellar DASEs and hemangioblastomas lacked immunoreactivity with antibody ZIC1 (Zic family member 1), a granule cell progenitor marker with concordance from oligonucleotide RNA expression array analyses. Rather, cerebellar DASEs and hemangioblastomas were immunoreactive with antibody PAX2 (paired box 2), a marker of basket/stellate cell progenitors. VHL cerebellar cortices also revealed PAX2-positive cells in Purkinje and molecular layers, resembling the histological and molecular development of basket/stellate cells in postnatal non-VHL mouse and human cerebella. These data suggest that VHL deficiency can result in the developmental arrest of basket/stellate cells in the human cerebellum and that these PAX2-positive, initiated cells await another insult or signal to form DASEs and eventually, tumors.