bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between vitamin D supplementation and fracture incidence in community-dwelling older adults: an updated systematic review and meta-analysis of randomized controlled trials
Authors: Tu Hengjia , Zhang Yuzhuo , You Zhixuan , Zhang Xintian 
Published: November 2022

Abstract
Previous studies have reached different conclusions regarding the effect of vitamin D supplementation and the incidence of fractures in the elderly. As more and more high-quality studies are published, an updated Meta-analysis is needed. We searched the PubMed, Cochrane Library, Embase, and Web of Science databases (from creation date to September 10, 2022) using the keywords vitamin D and fracture. We also searched at https://clinicaltrials.gov/ to search for unpublished clinical studies. Randomized clinical trials comparing vitamin D supplements with a placebo or no treatment for fracture incidence in community-dwelling adults older than 50 years was included. Hip fracture was defined as the primary outcome. Secondary outcomes were total fracture, vertebral fracture, and nonvertebral fracture. The protocol is available in PROSPERO (ID: CRD42022360619). A total of 15 randomized trials involving 53291 participants fulfilled the inclusion criteria. Supplementing with vitamin D had no significant effect on reducing the incidence of hip fracture (RR = 1.18, [95% CI, 0.99 − 0.41]), total fracture (RR = 1.01, [95% CI, 0.92–1.11]), vertebral fracture (RR = 0.97, [95% CI, 0.54–1.77]), or non-vertebral fracture (RR = 1.04, [95% CI, 0.97–1.12]). On the contrary, taking high doses of vitamin D once a year may increase the incidence of hip fractures (OR = 1.44, [95% CI, 1.03–2.02]). Besides, being in a low-light environment increased the incidence of hip fractures (OR = 1.25, [95% CI, 1.01–1.55]). There were no significant findings from subgroup analyses based on sex, fracture history, calcium consumption, baseline 25-hydroxyvitamin levels, or trial durations. Vitamin D use in community-dwelling older adults does not reduce the risk of fracture. High doses of vitamin D at one-year intervals may even increase the risk of fracture. In addition, older adults in low sunlight exposure areas had a higher risk of fracture regardless of vitamin D use.
Cellular population dynamics shape the route to human pluripotency
Authors: Elvassore Nicola , Gagliano Onelia , Panariello Francesco , Luni Camilla , Grimaldi Antonio , Angiolillo Silvia , Qin Wei , Manfredi Anna , Annunziata Patrizia , Slovin Shaked , Vaccaro Lorenzo , Riccardo Sara , Bouche Valentina , Dionisi Manuela , Salvi Marcello , Martewicz Sebastian , Hu Manli , Cui Meihua , Stuart Hannah , Laterza Cecilia , Baruzzo Giacomo , Schiebinger Geoffrey , Camillo Barbara Di , Cacchiarelli Davide 
Published: November 2022

Abstract
Human cellular reprogramming to induced pluripotency is still an inefficient process and this has long hindered the study of the role of critical intermediate stages. We take advantage of high efficiency reprogramming in microfluidics and temporal multi-omics to identify and resolve distinct sub-populations and their interactions. The combination of secretome analysis and single-cell transcriptomics shows functional extrinsic pathways of protein communication between reprogramming sub-populations and the re-shaping of a permissive extracellular environment.
We pinpointed the HGF/MET/STAT3 axis as a potent enhancer of reprogramming, which acts via HGF accumulation within the confined system of microfluidics, and in conventional dishes needs to be supplied exogenously to enhance efficiency.
Our data integrate the notion of human cellular reprogramming as a transcription factor-driven process, with the concept that it is deeply dependent on extracellular context and cell population determinants.
Jointly Optimize Energy Harvest Time and Device Pairing for D2D Communications underlaying Cellular Network
Authors: Wang Chaochao , Yang Kun , Hu Jie , Mei Haibo , Wang Ping 
Published: November 2022

Abstract

Nowadays, to realize device sustainability and prolong device working time, energy harvest (EH) has been introduced into D2D communication networks that allow each D2D equipment (DUE) to harvest the radio frequency (RF) energy from the facilities in proximity. However, in such an EH-enabled D2D network, it is challenging to integrate EH with the device pairing mechanism that is critical to the performance of the network. To this problem, we propose an optimization algorithm in this paper that jointly optimizes the energy harvesting time and the pairing for each DUE in a close-form to obtain the maximum throughput of the EH-enabled D2D network. In the proposed algorithm, each DUE will go through two mutually influenced stages, i.e., EH stage and information transmit stage, in which the device pairing will take the energy status of the candidate DUEs into consideration. The numerical results demonstrate that the joint optimization algorithm has a significant increased throughput for the EH-enabled D2D network, compared with other benchmark solutions.
Optimization of convergent angle of the Venturi meter for best coefficient of discharge
Authors: Khan Zohaib Ahmed , Jain Naman , Anbu Kumar S. 
Published: November 2022

Abstract
Computational fluid dynamics is a compelling apparatus for getting stream flow and anticipating how this flow will react to various limiting boundary conditions. With this learning, the focal point of this research is applying computational fluid elements such as CFD to issues dealing with stream flow measurement/estimation in closed conduits such as pipes utilizing differential stream meters like the Venturi meter. After thorough research from the existing literature, it was determined that the convergent angle (CA) of a standard Venturi meter has not been optimized yet. The range given for a standard ASME Venturi CA is 20–22°. More than 50 models were created and run in ANSYS FLUENT, which was used as a CFD tool. Three β-ratios are taken into consideration here, which are 0.4, 0.5 and 0.6. An optimum value of CA, corresponding to each β, is obtained by finding out the best coefficient of discharge (closest to 0.99) for each test value of CA. Another aspect explored in this research is the relationship between Reynolds number and coefficient of discharge. This is done with the integration of ANSYS FLUENT and laboratory results. The results of this study yield a definite value of CA for each β.
La cadena medieval de la iglesia de Santa María de Laredo (Cantabria)
Authors: BRÍGIDO GABIOLA Baldomero , CRIADO PORTAL Antonio José 
Published: November 2022

Se estudia la cadena de hierro conservada en la iglesia de Laredo y los acontecimientos de la conquista de Sevilla. Con el apoyo de un análisis metalográfico se analiza el hierro mediante microscopia óptica y electrónica de barrido complementado con un estudio de la variación de la dureza de la ferrita frente a un acero al carbono normalizado que certifican una cronología del siglo XIII gracias a los cambios microestructurales y su implicación en las propiedades mecánicas del hierro. Se propone que la cadena conservada se corresponde con la que se trajo por los marineros de Laredo tras la toma de Sevilla en 1248.
KAJIAN KERUSAKAN JALAN DENGAN MENGGUNAKAN METODE PAVEMENT CONDITION INDEX (PCI), PADA RUAS JALAN SIRAH PULAU PADANG – PAMPANGAN KM. 17+800 – KM. 19+200, KABUPATEN OGAN KOMERING ILIR
Authors: Wardono Herry , Widiatmoko Laksi , Widyawati Ratna 
Published: November 2022

Dalam perencanaan jalan usia pelayanan merupakan satu komponen yang sangat penting, dikarenakan lalu lintas jalan raya harus terus terlayani dengan kondisi terbaik. Untuk mencapai tujuan tersebut diperlukan adanya pemeliharaan jalan raya dengan manajemen asset. Dalam rangka pemeliharaan dan untuk mengetahui usia pemeliharaan tersebut diperlukan suatu system evaluasi kondisi perkerasan jalan. Pavement Condition Index (PCI) merupakan salah satu metode evaluasi perkerasan jalan yang telah diadaptasi secara luas dalam pemeliharaan jalan, jalan lapangan terbang dan juga perkerasan lahan parkir (Shahin, 2005). Dalam artikel ini objek penelitian dengan metode evaluasi PCI berlokasi di Jalan Sirah Pulau Padang dengan Pampangan KM. 17+800 – KM. 19+200 sepanjang 1400 meter, di Kabupaten Ogan Komering Ilir, Sumatera Selatan. Metode yang digunakan untuk mendapatkan nilai PCI akhir ruas jalan tersebut adalah dengan pengumpulan data melalui survey dan pengamatan visual, yang didata menggunakan format formulir data unit sample jalan yang mengacu pada standar ASTM International. Dari pengumpulan data tersebut selanjutnya akan didapati identifikasi tipe kerusakan, tingkat kerusakan (severity) dan juga kuantitas kerusakan. Tujuan penelitian ini adalah untuk mengkaji kondisi perkerasan jalan ruas Sirah Pulau Padang-Pampangan Kabupaten Ogan Komering Ilir dengan metode PCI. Dengan sampel KM. 17+800 – KM. 19-200 per 200-meter sepanjang 1400 m dengan jenis perkerasan aspal, sehingga didapati perolehan usulan penanganan yang lebih detail dan tenggat waktu pemeliharaan. Hasil akhir yang didapatkan melalui sampel yang diambil ini adalah 59,57% dimana nilai kondisi rata-rata jalan sepanjang 1400 meter yang dimulai dari KM. 17+800 – KM. 19+200 tersebut adalah Fair atau Sedang. Melalui metode PCI ini pula dapat diidentifikasi kerusakan spesifik yang perlu perhatian khusus agar tindakan perbaikan yang tepat dan efisien dapat diambil.
Factors Associated with Premenstrual Syndrome: A Cross-Sectional Study of Female Adolescents (Morocco)
Authors: Lghoul Siham , Loukid Mohamed , Benksim Abdelhafid , Hilali Mohamed Kamal 
Published: November 2022

Background: Premenstrual syndrome (PMS) is a heterogeneous disorder which includes physical and affective symptoms that most females of reproductive age experience during the luteal phase of their menstrual cycle. Objective: This study aims to investigate the factors associated with PMS among adolescent schoolgirls and to assess the severity of PMS. Methods: A cross sectional study conducted among 102 adolescents representing Marrakesh city. A structured questionnaire was used. Data analysis was done with SPSS version 26. Results: The rate of mild to severe PMS were 52.9 %, 25.5 % and 21.6 % respectively. The most common physical symptoms were backache (52.9%) and breast tenderness (36.3%), while the most common affective symptoms were irritability (49 %), anxiety (46.1 %) and mood swelling (45.1 %). Significant differences were observed between PMS group and non-PMS group in level of education (p< 0.05), sweets consumption (p< 0.05) and family’s status (p< 0.05). There was no significant association between PMS and BMI. Conclusion: Based on the findings, it seems that the occurrence of PMS is associated with sweet consumption frequency. This study showed also that the most common PMS symptoms were irritability and backache.
The Presentation of Interest Scale on Reflective Thinking and its Internal and External Validity
Authors: Gomes Cristiano M. A. , Jelihovschi Enio G. , De Araujo Jhonys 
Published: November 2022

Studies on prediction recognize the presence of a large number of predictors of school-academic performance, as well as the existence of well-established predictors, nevertheless some psychoeducational variables remain little explored, even though their great potential. One of these is reflective thinking. The Laboratory for Research on Cognitive Architecture (LAICO) at the Federal University of Minas Gerais brought forth a contribution to reflective thinking. This is the development of the Interest Scale on Reflective Thinking which measures the interest of people in thinking reflectively. In this paper we present the Interest Scale on Reflective Thinking where it is shown in detail its structure and content. We also show evidence of structural validity, external validity and reliability of the scale.
Histopathologic findings and survival outcomes of dogs undergoing liver lobectomy as treatment for spontaneous hemoabdomen secondary to a ruptured liver mass: retrospective analysis of 200 cases (2012–2020)
Authors: Reist Alexandra M. , Reagan Jennifer K. , Fujita Shawna K. , Walny Alexis M. 
Published: November 2022

Abstract

OBJECTIVE
To describe the distribution of histopathologic diagnoses in a large population of dogs undergoing surgical treatment for spontaneous hemoperitoneum secondary to a ruptured liver mass. Additionally, to describe survival outcomes and assess for prognostic factors for overall survival time in this population.

ANIMALS
200 client-owned dogs with spontaneous hemoperitoneum resulting from a liver mass.

PROCEDURES
Medical records from 19 veterinary referral hospitals were reviewed. Data collected included signalment, clinical signs, blood work, radiographic and ultrasonographic findings, surgical methods, intraoperative and postoperative complications, outcomes, and histopathologic findings. Follow-up information was obtained by contacting the referring veterinarian or owner.

RESULTS
Well-differentiated hepatocellular carcinoma, benign masses, hemangiosarcoma, and other malignant tumors accounted for 36% (72/200), 27.5% (55/200), 25.5% (51/200), and 11% (22/200) of cases, respectively. Overall survival time for all dogs was 356 days and for the above categories was 897 days, 905 days, 45 days, and 109 days, respectively. Prognostic factors for survival included diagnosis, increased ALT, anemia, and whether a transfusion was received. Overall survival time in dogs with increased ALT was 644 versus 63 days with normal values.

CLINICAL RELEVANCE
The majority of dogs (63.5%) were diagnosed with well-differentiated hepatocellular carcinoma or a benign process, resulting in favorable long-term survival. The distribution of histopathology for ruptured liver masses resulting in hemoperitoneum has not been previously reported and may be useful for client discussions prior to surgery.
Proteomic analysis of tear film in canine diabetic patients with and without retinopathy
Authors: Winiarczyk Dagmara , Winiarczyk Mateusz , Balicki Ireneusz , Szadkowski Mateusz , Michalak Katarzyna , Winiarczyk Stanisław , Adaszek Łukasz 
Published: November 2022

Abstract

Introduction
Diabetic retinopathy (DR) is the leading cause of blindness in human and animal patients. Early detection and treatment of the disease are important and can be facilitated by proteomic approaches providing biomarkers.

Material and Methods
Tear films were collected on Schirmer strips from 32 canine patients (12 diabetic dogs without changes in the retina, 8 diabetic dogs with signs of DR, and 12 control dogs). Two-dimensional electrophoresis was used to separate tear film proteins prior to their identification with matrix-assisted laser desorption/ionisation–tandem time-of-flight mass spectrometry and interrogation of protein function databases to find matches.

Results
Five significantly differentially expressed proteins were identified; of those, one was downregulated (2ʹ-5ʹ-oligoadenylate synthase 3) and four were upregulated in the tear film of two diabetic groups (Ras-related protein RAB-13; aldo-keto-reductase family 1 member C3; 28S ribosomal protein S31, mitochondrial; and 60S ribosomal protein L5). The differentially expressed proteins identified in the tear film were involved in signalling pathways associated with impaired protein clearance, persistent inflammation and oxidative stress.

Conclusion
The results of our study confirm that the pathological process in the retina in the course of diabetes mellitus causes changes in the tear film proteome.
Lessons Learned From Teaching System Thinking To Engineering Students
Authors: Azad Amin , Moore Emily 
Published: November 2022

There are frequent calls for engineers to build integrated approaches to complex social and environmental problems. However, engineering education provides little opportunity to explore these "wicked problems".
Given the complexity of the challenges, engineers face upon graduation, introducing students to systems thinking approaches and wicked problems could greatly benefit their ability to deal with complex challenges in the real world. At the University of Toronto, we have been taking part in the initiative to design a course with the primary topic of Systems Thinking targeted towards upper-year students from all disciplines. The objective of this course is not for student teams to get to a solution, but more so to develop an understanding of the wicked problem they are working on while educating them to leverage system thinking tools for visualizing their problem space and system mapping techniques to look at open systems.
This presentation will share our observations of the interactions, lessons learned, and challenges we faced during our first iteration of this course. The objective of this paper is to start an ongoing thread about the progress of teaching systems thinking concepts to engineering students throughout the upcoming years, along with the learning outcomes established from this course. In the future, we want to extract the data gathered from this course and research systems thinking principles and their benefits in approaching wicked problems.
Multi-Disciplinary Design Activity for Undergraduate and Graduate Engineering Students
Authors: Gryguc Andrew , Rennick Chris , Roufail Reem , Bedi Sanjeev 
Published: November 2022

This paper describes a project with common equipment that was adapted and offered to both an undergraduate and a graduate-level course with learning outcomes tailored specifically to each group of students. This project is an immersive, multi-disciplinary engineering design activity with a focus on materials, solid mechanics, and instrumentation. The activity incorporates aspects of fundamental engineering theory, virtual predictive simulation, as well as physical testing and data collection. All of this was done in the context of a material selection and failure analysis of a piece of furniture (cantilever chair) which is a simplistic and recognizable device by the students.
The project focusses on structural analysis of the chair under a variety of loading conditions, coupled with a virtual simulation model using Finite Element Analysis (FEA). FEA is utilized to identify critical regions of the structure which are prone to failure. The complexity, constraints, and provided resources of the model varied, depending on the specific implementation of the course. Finally, a physical test apparatus was constructed and used to generate experimental responses that the students were able to use to calibrate their predictive model and theoretical hand calculations.
This activity was created initially for in-person instruction but was adapted for remote delivery during the pandemic. Both qualitative and quantitative data collected from 2nd year and graduate students indicated that the activity was effective in improving several forms of knowledge acquisition. This paper will discuss in detail how a common project platform was adapted for the two academic levels with evidence of its efficacy
Pre-Production of a Gamified Experience for Creating New Design Thinking Mindset
Authors: Ebrahimi Shelir , Yazdanpanah Reza , Taghvaei Armaghan 
Published: November 2022

In a rapidly changing world, Canadian Universities are preparing students by developing learner-centered experiential learning programs. Most of these programs within Engineering are mainly project-based courses to provide an opportunity for students to practice design-thinking process along with other technical skills. Engineering students are usually competent with the technical aspects of the design-thinking process, but they struggle to grasp the importance of the early steps that focus on understanding the challenge and generating ideas.
A team of educators have come together to create gamified experiences to guide students through idea generation process. This mini-project is part of a larger work that focuses on the design and the development of a multi-component online course to train students in creating new engineering design thinking mindset.
This paper that is a small piece of an on-going effort, focuses on the design and the test run of a gamified experience based on the concept of “what if?” question to help students to generate more ideas.
Using online to enhance student engagement of design reviews and lessons learned experiences
Authors: Harvel Glenn 
Published: November 2022

This paper is about using the online environment to increase engagement in design and instilling a recognition of the importance of life long learning. The work assesses changes in the delivery of a 4th year nuclear engineering design course and evaluates changes in the delivery of the course as it migrated from face to face to hybrid to online. In particular, the design review process was used to enhance engagement of the student body and a lessons learned exercise was used to enhance reflection on life long learning. The engagement is assessed in terms of class attendance, activity within the learning management system, and direct engagement in the design review process. The design review process requires each student to both present a design and to critique another group’s design. The design work is done as a team but the critique is done as an individual paralleling the industry process currently in use for the nuclear sector. In addition to the technical details, the performance of each student with respect to their soft skills is also assessed. This includes the number of students that actively engage or passively engage during both presentation and critique stages. Following the design review process, the students then engage in a lessons learned activity similar to what is done in the industry but simplified to focus on their experience. The activity also included an opportunity to reflect on themselves and establish a life long learning plan to address their personal findings. Note the paper will not discuss the personal findings specifically but instead will comment on the engagement of the students. Before using online approaches, the students fell into two distinct groups. One set was strongly active in the design review process and the other set was strongly resistive to participation and did the minimum necessary to get through the exercise. It was very clear that many students felt uncomfortable speaking openly in front of others. This changed significantly with the use of online technology. There was a significant increase in the number of students that engaged or at least felt comfortable to speak in the online setting. Some students displayed perhaps too much comfort in working from their personal environment space. This observation was also noted in the lessons learned exercise where the students went from saying the minimum necessary to having a large amount of insightful comments to make. The results suggest that allowing online participation in the experience has encouraged engagement of students that would resist a face to face experience.