bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving The Quality of Students' Learning in Fiqh Subjects of Hajj and Umrah Materials through Cooperative Script Learning Model
Authors: Shobirin Mochammad Syafiuddin , Zulfa Mariatul 
Published: April 2022

The purpose of this research is to fulfill the final task and to find out the improvement of students' learning outcomes through cooperative script learning model in the subjects of fiqh of hajj and umrah materials in MA AL-BAIRUNY sambongdukuh jombang. The stages of researchers to obtain information begins with the presence of researchers to the location directly looking for data sources through observation methods, interviews and documentation. As a data collection step to find out how the learning process in MA AL-BAIRUNY sambongdukuh jombang. Based on the results of research MA AL-BAIRUNY sambongdukuh jombang has not implemented the cooperative script learning model and to improve student learning outcomes is to apply cooperative script learning model in class X in fiqh subjects through the first few stages are planning, implementation and evaluation. For the results of learning students are conducted with pretest and postest assessment based on the results of research obtained learning results through the cooperative script prison model
Development of Communicative-Based Teaching Materials in Aqidah Akhlaq Subjects
Authors: Permatasari Novia Maharani , Shofiyani Amrini 
Published: April 2022

This research entitled "Development of Communicative-Based Teaching Materials in Aqidah Akhlaq Subjects "aims to improve learning by choosing the right strategy, procurement of efficient and interesting teaching materials. Also in order to achieve the learning target in accordance with the provisions set. Therefore, teaching materials are the most important component in learning. One of the main elements or urgent parts of the curriculum is teaching materials.
Therefore the teacher as someone who delivers students to achieve goals or competencies, and must understand the principles in the development of teaching materials. In the new normal some schools use an online system, it is necessary to have communicative teaching materials so that they can be used and learned independently by students. Especially in a class that in fact has just entered junior high school. So it can help students in understanding online learning materials are felt less. Moreover, learning aqidah akhlaq to shape the personality of students in order to have a strong faith and laughter. so that his life is decorated with noble akhlaq.
ASSESSMENT OF AIR QUALITY ACROSS DIFFERENT LAND USES IN GWAGWALADA TOWN, FCT-ABUJA, NIGERIA
Authors: Sunday Ishaya , Omede Emmanuel 
Published: April 2022

This study assessed ambient air quality (NO2, SO2, CO, NH3, H2S and PM10) across four different urban land uses at five points each using Handheld BW Tech GasAlert and Haze Dust Particulate Monitor in Gwagwalada town, FCT, Nigeria. The standard limit of WHO, USEPA and FME were used. CO concentration across the different land use “Abattoir (4.4), Market (0), Motor Park (3.4) and Roadside (6.4)” were within the limit of WHO, USEPA and FME (10, 9, 9 ppm/ug/m3); NO2 and H2S were within the limit of WHO, USEPA and FEME (0.07, 0.02, 0.05 ppm/ug/m3); SO2 concentration across Abattoir (0.34), Market (0.28), Motor Park (0.26) and Roadside (0.32)” were above the limit of WHO and FME (0.01ppm/ug/m3), but falls within the standard of USEPA (0.5ppm/ug/m3); PM10 concentration at Abattoir (142.49), Market (72.54), Motor Park (162.88) and Roadside (148.54) were within the standard of FME (250 ppm/ug/m3) and USEPA (150 ppm/ug/m3) with the exception of PM10 concentration in Motor Park while the PM concentration were above the standard of WHO (50 ppm/ug/m3) across the different land uses. NH3 were not detected in Motor Park and Roadside, but its concentration in Abattoir (0.12) and Market area (0.1) were above the standard of WHO and USEPA (0.07) but commensurate to that of the FME. ANOVA at 0.05% level of significance shows that there is no significant difference in the concentration of pollutants across the different land uses as justified with P ≤ .963. The air quality index rating depicts PM10 and
La Nefrologia incontra il Nursing e la Medicina Narrativa: una ricerca di triangolazione. Un nuovo approccio alla malattia
Authors: Raugei Lapo , Lombardi Marco 
Published: April 2022

Introduction: In the late 20th Century, Kleinman and Good created Narrative Medicine (NM). In the following years, this method made its way in healthcare, reaching the peak in 2009 when R. Charon set up the first academic course of Narrative Medicine. Nevertheless, NM is still not well known and used. The main goal of this survey is attempting to understand the emotions felt by the patient while telling his/her own illness’ experience and then understand whether this approach improves therapy.
Methods: The survey is developed through a methodological triangulation research consisting of a qualitative part, where 24 stories selected from the first two editions of “Quirino Maggiore” National Competition were analysed through the Van Kaam method, and a quantitative research, performed through a questionnaire submitted to patients suffering from chronic kidney disease thanks to the National Association of Hemodialysis Patients (ANED) and to Onlus Santa Maria Annunziata, Bagno a Ripoli, Florence. We received responses from 219 patients between 24 September 2021 and 18 October 2021.
Results: The qualitative research identified 94 expressions grouped in 10 labels in which the most representative themes come to light. Through the questionnaire we can see that most people are not familiar with Nursing and Narrative Medicine, but that they consider the relationship between patients and healthcare workers very important.
Conclusions: Although it’s impossible to generalize the results, we can understand that Nursing and Narrative Medicine should be more integrated into the care pathway. Furthermore, healthcare workers should be trained in a suitable way.
Measuring harvest residue accumulations at New Zealand’s steepland log-making sites
Authors: Harvey Campbell 
Published: April 2022

Background: When harvesting plantation forests of Pinus radiata (D.Don) in New Zealand, large residue piles commonly accumulate on or adjacent to processing sites. While the merchantable volume that is transported to market is carefully measured, little is known of the quantity of the piled, residual material. A working knowledge of residues is becoming more important as it is not only a potentially merchantable product for the bioenergy market, but when stored in perpetuity it can present a risk of self-ignition, and specifically on steep slopes, it presents a mobilisation risk if not stored correctly.
Methods: The area, bulk volume and depth of residue piles at 16 recently harvested steepland sites were measured from a wide geographic spread across New Zealand. Unmanned Aerial Vehicle imagery was used to build georeferenced photogrammetric models of residue piles (94 per cent of the studied volume). Pile area was determined from interpreting boundaries from orthophotos and volumes determined by interpolating the obscured terrain surfaces on duplicate photogrammetric models. The remaining 6 per cent of pile volume was measured with handheld GPS tracking of the perimeters and on-site estimation of average pile depth.
Results: For a mean harvest area of 18.9 ha, there was a mean of 2.4 piles per harvest site, 2600 m3 bulk volume and 2900 m2 of area covered. For every hectare harvested, a bulk volume of 170 m3 is piled at the landing, or alternatively, 0.23 m3 of bulk pile volume per tonne harvested. The manual terrain interpolation methodology was tested against collecting georeferenced pre-harvest terrain surfaces, yielding an average difference of 19% across two sites and six residue piles.
Conclusions: This research demonstrates the ability to investigate the bulk volume and site coverage of landing residue piles with equipment and software tools available to today’s forester. Mean values for pile area and volume are presented to reflect the current state of knowledge and can be a reference point for future initiatives.
FLOUTING MAXIMS IN “FANTASTIC BEASTS: AND WHERE TO FIND THEM” MOVIE
Authors: Erdayani Erdayani , Ambalegin Ambalegin 
Published: April 2022

This descriptive qualitative research purposed at finding the types of flouting maxims uttered by the characters in Fantastic Beasts: and Where to Find Them movie. The data were taken from the utterances contained flouting maxims in the movie. The cooperative principle theory by (Grice, 1975) conducted for analyzing the types of flouting maxims. Observational method and non-participatory technique implemented for collecting the data. Furthermore, pragmatic identity method and pragmatic competence- in equalizing technique employed for analyzing the data. The findings revealed that there were 15 utterances contained flouting maxims uttered by the characters in the movie. There were 9 data of flouting maxim of quantity, 1 data of flouting maxim of relation, 4 data of flouting maxim of relation, and 1 data of flouting maxim of manner. Flouting maxim of quantity became the most uttered because the characters frequently flouted the maxim of quantity in the movie.
The Dictyostelium Model for Mucolipidosis Type IV
Authors: Allan Claire Y. , Fisher Paul R. 
Published: April 2022

Mucolipidosis type IV, a devastating neurological lysosomal disease linked to mutations in the transient receptor potential channel mucolipin 1, TRPML1, a calcium permeable channel in the membranes of vesicles in endolysosomal system. TRPML1 function is still being elucidated and a better understanding of the molecular pathogenesis of Mucolipidosis type IV, may facilitate development of potential treatments. We have created a model to study mucolipin function in the eukaryotic slime mould Dictyostelium discoideum by altering expression of its single mucolipin homologue, mcln. We show that in Dictyostelium mucolipin overexpression contributes significantly to global chemotactic calcium responses in vegetative and differentiated cells. Knockdown of mucolipin also enhances calcium responses in vegetative cells but does not affect responses in 6–7 h developed cells, suggesting that in developed cells mucolipin may help regulate local calcium signals rather than global calcium waves. We found that both knocking down and overexpressing mucolipin often, but not always, presented the same phenotypes. Altering mucolipin expression levels caused an accumulation or increased acidification of Lysosensor Blue stained vesicles in vegetative cells. Nutrient uptake by phagocytosis and macropinocytosis were increased but growth rates were not, suggesting defects in catabolism. Both increasing and decreasing mucolipin expression caused the formation of smaller slugs and larger numbers of fruiting bodies during multicellular development, suggesting that mucolipin is involved in initiation of aggregation centers. The fruiting bodies that formed from these smaller aggregates had proportionately larger basal discs and thickened stalks, consistent with a regulatory role for mucolipin-dependent Ca2+ signalling in the autophagic cell death pathways involved in stalk and basal disk differentiation in Dictyostelium. Thus, we have provided evidence that mucolipin contributes to chemotactic calcium signalling and that Dictyostelium is a useful model to study the molecular mechanisms involved in the cytopathogenesis of Mucolipidosis type IV.
Extreme Point Sort Transformation Combined With a Long Short-Term Memory Network Algorithm for the Raman-Based Identification of Therapeutic Monoclonal Antibodies
Authors: Ling Jin , Zheng Luxia , Xu Mingming , Chen Gang , Wang Xiao , Mao Danzhuo , Shao Hong 
Published: April 2022

Therapeutic monoclonal antibodies (mAbs) are a new generation of protein-based medicines that are usually expensive and thus represent a target for counterfeiters. In the present study, a method based on Raman spectroscopy that combined extreme point sort transformation with a long short-term memory (LSTM) network algorithm was presented for the identification of therapeutic mAbs. A total of 15 therapeutic mAbs were used in this study. An in-house Raman spectrum dataset for model training was created with 1,350 spectra. The characteristic region of the Raman spectrum was reduced in dimension and then transformed through an extreme point sort transformation into a sequence array, which was fitted for the LSTM network. The characteristic array was extracted from the sequence array using a well-trained LSTM network and then compared with standard spectra for identification. To demonstrate whether the present algorithm was better, ThermoFisher OMNIC 8.3 software (Thermo Fisher Scientific Inc., U.S.) with two matching modes was selected for comparison. Finally, the present method was successfully applied to identify 30 samples, including 15 therapeutic mAbs and 15 other injections. The characteristic region was selected from 100 to 1800 cm−1 of the full spectrum. The optimized dimensional values were set from 35 to 53, and the threshold value range was from 0.97 to 0.99 for 15 therapeutic mAbs. The results of the robustness test indicated that the present method had good robustness against spectral peak drift, random noise and fluorescence interference from the measurement. The areas under the curve (AUC) values of the present method that were analysed on the full spectrum and analysed on the characteristic region by the OMNIC 8.3 software’s built-in method were 1.000, 0.678, and 0.613, respectively. The similarity scores for 15 therapeutic mAbs using OMNIC 8.3 software in all groups compared with that of the relative present algorithm group had extremely remarkable differences (p &lt; 0.001). The results suggested that the extreme point sort transformation combined with the LSTM network algorithm enabled the characteristic extraction of the therapeutic mAb Raman spectrum. The present method is a proposed solution to rapidly identify therapeutic mAbs.
Unravelling the Difference Between Men and Women in Post-CABG Survival
Authors: Schmidt Amand F. , Haitjema Saskia , Sartipy Ulrik , Holzmann Martin J. , Malenka David J. , Ross Cathy S. , van Gilst Wiek , Rouleau Jean L. , Meeder Annelijn M. , Baker Robert A. , Shiomi Hiroki , Kimura Takeshi , Tran Lavinia , Smith Julian A. , Reid Christopher M. , Asselbergs Folkert W. , den Ruijter Hester M. 
Published: April 2022

ObjectivesWomen have a worse prognosis after coronary artery bypass grafting (CABG) surgery compared to men. We sought to quantify to what extent this difference in post-CABG survival could be attributed to sex itself, or whether this was mediated by difference between men and women at the time of intervention. Additionally, we explored to what extent these effects were homogenous across patient subgroups.MethodsTime to all-cause mortality was available for 102,263 CABG patients, including 20,988 (21%) women, sourced through an individual participant data meta-analysis of five cohort studies. Difference between men and women in survival duration was assessed using Kaplan–Meier estimates, and Cox’s proportional hazards model.ResultsDuring a median follow-up of 5 years, 13,598 (13%) patients died, with women more likely to die than men: female HR 1.20 (95%CI 1.16; 1.25). We found that differences in patient characteristics at the time of CABG procedure mediated this sex effect, and accounting for these resulted in a neutral female HR 0.98 (95%CI 0.94; 1.02). Next we performed a priori defined subgroup analyses of the five most prominent mediators: age, creatinine, peripheral vascular disease, type 2 diabetes, and heart failure. We found that women without peripheral vascular disease (PVD) or women aged 70+, survived longer than men (interaction p-values 0.04 and 6 × 10–5, respectively), with an effect reversal in younger women.ConclusionSex differences in post-CABG survival were readily explained by difference in patient characteristics and comorbidities. Pre-planned analyses revealed patient subgroups (aged 70+, or without PVD) of women that survived longer than men, and a subgroup of younger women with comparatively poorer survival.
Relationship Between Circulating MicroRNAs and Left Ventricular Hypertrophy in Hypertensive Patients
Authors: Lopes Elisangela C. P. , Paim Layde R. , Carvalho-Romano Luís F. R. S. , Marques Edmilson R. , Minin Eduarda O. Z. , Vegian Camila F. L. , Pio-Magalhães José A. , Velloso Lício A. , Coelho-Filho Otavio R. , Sposito Andrei C. , Matos-Souza José R. , Nadruz Wilson , Schreiber Roberto 
Published: April 2022

ObjectiveLeft ventricular hypertrophy (LVH) is a common complication of hypertension and microRNAs (miRNAs) are considered to play an important role in cardiac hypertrophy development. This study evaluated the relationship between circulating miRNAs and LVH in hypertensive patients.MethodsTwo cohorts [exploratory (n = 42) and validation (n = 297)] of hypertensive patients were evaluated by clinical, laboratory and echocardiography analysis. The serum expression of 754 miRNAs in the exploratory cohort and 6 miRNAs in the validation cohort was evaluated by the TaqMan OpenArray® system and quantitative polymerase chain reaction, respectively.ResultsAmong the 754 analyzed miRNAs, ten miRNAs (miR-30a-5p, miR-let7c, miR-92a, miR-451, miR-145-5p, miR-185, miR-338, miR-296, miR-375, and miR-10) had differential expression between individuals with and without LVH in the exploratory cohort. Results of multivariable regression analysis adjusted for confounding variables showed that three miRNAs (miR-145-5p, miR-451, and miR-let7c) were independently associated with LVH and left ventricular mass index in the validation cohort. Functional enrichment analysis demonstrated that these three miRNAs can regulate various genes and pathways related to cardiac remodeling. Furthermore, in vitro experiments using cardiac myocytes demonstrated that miR-145-5p mimic transfection up-regulated the expression of brain and atrial natriuretic peptide genes, which are markers of cardiac hypertrophy, while anti-miR-145-5p transfection abrogated the expression of these genes in response to norepinephrine stimulus.ConclusionsOur data demonstrated that circulating levels of several miRNAs, in particular miR-145-5p, miR-451, and let7c, were associated with LVH in hypertensive patients, indicating that these miRNAS may be potential circulating biomarkers or involved in hypertension-induced LV remodeling.
Clinical Impact and Prognostic Role of Triglyceride to High-Density Lipoprotein Cholesterol Ratio in Patients With Chronic Coronary Syndromes at Very High Risk: Insights From the START Study
Authors: De Luca Leonardo , Temporelli Pier Luigi , Colivicchi Furio , Gonzini Lucio , Fasano Maria Luisa , Pantaleoni Massimo , Greco Gabriella , Oliva Fabrizio , Gabrielli Domenico , Gulizia Michele Massimo 
Published: April 2022

BackgroundSeveral studies have reported that the combination of high TG and low HDL-C, as simplified by the TG/HDL-C ratio, was a predictor of cardiovascular disease independent of LDL-C level. Nevertheless, poor data are available on the predictive role of TG/HDL-C ratio in very high risk (VHR) patients with chronic coronary syndromes (CCS).MethodsUsing the data from the STable Coronary Artery Diseases RegisTry (START) study, an Italian nationwide registry, we assessed the association between the TG/HDL-C ratio and baseline clinical characteristics, pharmacological treatment, and major adverse cardio-cerebrovascular events (MACCE) at 1 year in a large cohort of CCS patients at VHR.ResultsVHR patients with both TG and HDL-C levels available were grouped in tertiles of TG/HDL-C ratio: low (TG/HDL-C ratio &lt;2, n = 967), middle (TG/HDL-C ratio 2–3.3, n = 1,071) and high (TG/HDL-C ratio &gt;3.3, n = 1,028). At 1 year from enrolment, 232 (7.6%) patients presented a MACCE, with a higher incidence in the higher tertile, even though not statistically significant (6.0, 8.2, and 8.4% in the low, middle and high tertile, respectively; p = 0.08). At multivariable analysis, the TG/HDL-C ratio in tertiles did not result an independent predictor of the MACCE (p = 0.29) at 1-year follow-up (HR: 1.30; 95% CI: 0.93–1.82; p = 0.12 middle vs. lower tertile, and HR: 1.22; 95% CI: 0.87–1.72; p = 0.25 higher vs. lower).ConclusionsIn the present large, nationwide cohort of CCS patients at VHR a high TG/HD ratio did not emerge as independent predictor of MACCE at 1 year. Further studies with a longer follow-up are needed to better define the prognostic role of TG/HDL ratio in CCS.
Thermodynamic Properties of Fe-Bearing Wadsleyite and Determination of the Olivine-Wadsleyite Phase Transition Boundary in (Mg,Fe)2SiO4 System
Authors: Su Chang , Liu Yonggang , Fan Dawei , Song Wei , Jiang Jiyi , Sun Zhenjun , Yang Guang 
Published: April 2022

The self-consistent molar volumes, elastic properties and thermodynamic properties of β-(Mg0.87,Fe0.13)2SiO4wadsleyite have been determined over a wide temperature and pressure range based on an iterative numerical approach and experimental data from the literature. The obtained molar volumes, adiabatic bulk modulus, and shear modulus generally agree with the available experimental and theoretical results. The thermodynamic properties of α-(Mg0.9,Fe0.1)2SiO4were also reinvestigated. Comparisons on thermodynamic properties show that the thermal expansions, heat capacities, and entropies of both β-(Mg0.87,Fe0.13)2SiO4and α-(Mg0.9,Fe0.1)2SiO4exhibit negative and nonlinear behavior with increasing pressure. Besides, the pressure plays a more important role in thermodynamic properties of the α-(Mg0.9,Fe0.1)2SiO4than that of the β-(Mg0.87,Fe0.13)2SiO4. Using the Clausius-Clapeyron equation combined with molar volumes and entropies of both compositions, the phase transition boundary of Fe-bearing olivine and wadsleyite is estimated. The calculated transition pressure shows a nonlinear relationship with increasing temperature, and the value is generally lower than the previous studies on Fe-free olivine and wadsleyite at the same temperature. On the basis of our phase relation, the temperature at the 410 km discontinuity is estimated as 1795 ± 70 K under anhydrous conditions. The results not only confirm the feasibility of the Clausius-Clapeyron equation in obtaining the solid-solid phase transition, but also suggest that the existence of Fe might decrease the transition pressure of olivine-wadsleyite, which would consequently cause a higher temperature at the 410 km discontinuity.