bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bearing fault diagnosis method based on improved Siamese neural network with small sample
Authors: Zhao Xiaoping , Ma Mengyao , Shao Fan 
Published: November 2022

AbstractFault diagnosis of rolling bearings is very important for monitoring the health of rotating machinery. However, in actual industrial production, owing to the constraints of conditions and costs, only a small number of bearing fault samples can be obtained, which leads to an unsatisfactory effect of traditional fault diagnosis models based on data-driven methods. Therefore, this study proposes a small-sample bearing fault diagnosis method based on an improved Siamese neural network (ISNN). This method adds a classification branch to the standard Siamese network and replaces the common Euclidean distance measurement with a network measurement. The model includes three networks: a feature extraction network, a relationship measurement network, and a fault classification network. First, the fault samples were input into the same feature extraction network in pairs, and a long and short-term memory (LSTM) network and convolutional neural network (CNN) were used to map the bearing signal data to the low-dimensional feature space. Then, the extracted sample features were measured for similarity by the relationship measurement network; at the same time, the features were input into the classification network to complete the bearing fault recognition. When the number of training samples was particularly small (training set A, 10 samples), the accuracy of 1D CNN, Prototype net and Siamese net were 49.8%, 60.2% and 58.6% respectively, while the accuracy of the proposed ISNN method was 84.1%. For the 100-sample case of training set D, the accuracy of 1D CNN was improved to 93.4%, which was still higher than that of prototype and Siam network, while the accuracy of ISNN method reached 98.1%.The experimental results show that the method in this study achieved higher fault diagnosis accuracy and better generalization in the case of small samples.
In-depth analysis and open challenges of Mist Computing
Authors: López Escobar Juan José , Díaz Redondo Rebeca P. , Gil-Castiñeira Felipe 
Published: November 2022

AbstractThe advent and consolidation of the Massive Internet of Things (MIoT) comes with a need for new architectures to process the massive amount of generated information. A new approach, Mist Computing, entails a series of changes compared to previous computing paradigms, such as Cloud and Fog Computing, with regard to extremely low latency, local smart processing, high mobility, and massive deployment of heterogeneous devices. Hence, context awareness use cases will be enabled, which will vigorously promote the implementation of advantageous Internet of Things applications. Mist Computing is expected to reach existing fields, such as Industry 4.0, future 6G networks and Big Data problems, and it may be the answer for advanced applications where interaction with the environment is essential and lots of data are managed. Despite the low degree of maturity, it shows plenty of potential for IoT together with Cloud, Fog, and Edge Computing, but it is required to reach a general agreement about its foundations, scope, and fields of action according to the existing early works. In this paper, (i) an extensive review of proposals focused on Mist Computing is done to determine the application fields and network elements that must be developed for certain objectives, besides, (ii) a comparative assessment between Cloud, Fog, Edge, and Mist is completed and (iii) several research challenges are listed for future work. In addition, Mist Computing is the last piece to benefit from the resources of complete network infrastructures in the Fluid Computing paradigm.
Prognostic markers for the clinical course in the blood of patients with SARS-CoV-2 infection
Authors: Fischer Johannes C. , Balz Vera , Jazmati Danny , Bölke Edwin , Freise Noemi F. , Keitel Verena , Feldt Torsten , Jensen Björn-Erik Ole , Bode Johannes , Lüdde Tom , Häussinger Dieter , Adams Ortwin , Schneider E. Marion , Enczmann Jürgen , Rox Jutta M. , Hermsen Derik , Schulze-Bosse Karin , Kindgen-Milles Detlef , Knoefel Wolfram Trudo , van Griensven Martijn , Haussmann Jan , Tamaskovics Balint , Plettenberg Christian , Scheckenbach Kathrin , Corradini Stefanie , Pedoto Alessia , Maas Kitti , Schmidt Livia , Grebe Olaf , Esposito Irene , Ehrhardt Anja , Peiper Matthias , Buhren Bettina Alexandra , Calles Christian , Stöhr Andreas , Gerber Peter Arne , Lichtenberg Artur , Schelzig Hubert , Flaig Yechan , Rezazadeh Amir , Budach Wilfried , Matuschek Christiane 
Published: November 2022

Abstract
Background
The presentation of peptides and the subsequent immune response depend on the MHC characteristics and influence the specificity of the immune response. Several studies have found an association between HLA variants and differential COVID-19 outcomes and have shown that HLA genotypes are associated with differential immune responses against SARS-CoV-2, particularly in severely ill patients. Information, whether HLA haplotypes are associated with the severity or length of the disease in moderately diseased individuals is absent.

Methods
Next-generation sequencing-based HLA typing was performed in 303 female and 231 male non-hospitalized North Rhine Westphalian patients infected with SARS-CoV2 during the first and second wave. For HLA-Class I, we obtained results from 528 patients, and for HLA-Class II from 531. In those patients, who became ill between March 2020 and January 2021, the 22 most common HLA-Class I (HLA-A, -B, -C) or HLA-Class II (HLA –DRB1/3/4, -DQA1, -DQB1) haplotypes were determined. The identified HLA haplotypes as well as the presence of a CCR5Δ32 mutation and number of O and A blood group alleles were associated to disease severity and duration of the disease.

Results
The influence of the HLA haplotypes on disease severity and duration was more pronounced than the influence of age, sex, or ABO blood group. These associations were sex dependent. The presence of mutated CCR5 resulted in a longer recovery period in males.

Conclusion
The existence of certain HLA haplotypes is associated with more severe disease.
Increased risk of COVID-19 mortality rate in IFITM3 rs6598045 G allele carriers infected by SARS-CoV-2 delta variant
Authors: Gholami Melika , Sakhaee Fatemeh , Sotoodehnejadnematalahi Fattah , Zamani Mohammad Saber , Ahmadi Iraj , Anvari Enayat , Fateh Abolfazl 
Published: November 2022

Abstract
Background
The interferon-induced transmembrane-protein 3 (IFITM3) is a vital component of the immune system's defense against viral infection. Variants in the IFITM3 gene have been linked to changes in expression and the risk of severe Coronavirus disease 2019 (COVID-19). This study aimed to investigate whether IFITM3 rs6598045, quantitative polymerase chain reaction (qPCR) cycle threshold (Ct) values, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are associated with an increased mortality rate of COVID-19.

Methods
The genotyping of IFITM3 rs6598045 polymorphism was analyzed using the amplification refractory mutation system-polymerase chain reaction in 1342 recovered and 1149 deceased patients positive for SARS-CoV-2.

Results
In this study, IFITM3 rs6598045 G allele as minor allele frequency was significantly more common in the deceased patients than in the recovered ones. Furthermore, the highest mortality rates were observed in Delta variant and lowest qPCR Ct values. COVID-19 mortality was associated with IFITM3 rs6598045 GG and AG in Delta variant and IFITM3 rs6598045 AG in Alpha variant. A statistically significant difference was observed in the qPCR Ct values between individuals with GG and AG genotypes and those with an AA genotype.

Conclusion
A possible correlation was observed between the mortality rate of COVID-19, the G allele of IFITM3 rs6598045, and SARS-CoV-2 variants. However, large-scale research is still required to validate our results.
A novel workflow for geothermal exploration: 3D seismic interpretation of biohermal buildups (Upper Jurassic, Molasse Basin, Germany)
Authors: Wolpert Philipp , Aigner Thomas , Bendias Daniel , Beichel Kilian , Zosseder Kai 
Published: November 2022

AbstractThe Upper Jurassic carbonates are the prime target for deep geothermal exploration in the Molasse basin, South Germany. The carbonates have a thickness of over 500m (1640 ft) and consist of two major facies: (1) bedded marly limestone and (2) massive limestone and dolostone. The massive limestone facies is composed of sponge-microbial biohermal buildups It is considered the main geothermal reservoir facies. Only this facies type may be (1) karstified, (2) dolomitized, and/or (3) faulted and fractured, and therefore can yield very high flow rates of >100 l/sec = 26 gps. The main data source used in this study is the 3D seismic survey of the Freiham geothermal field in the western part of Munich/Germany. Blended in were cutting logs to describe the lithology from 2 wells and borehole image logs from the two geothermal wells. Lithologies derived from these wells were upscaled in support of the seismic interpretation. The study presents an integrated workflow of 3D seismic attribute analysis to analyze the distribution and quantification of reservoir facies (massive limestone) versus non-reservoir facies (bedded marly limestone) per time slice. The attribute “sum of magnitude” is mapped for 9-time slices based on the vertical resolution of the Freiham 3D cube. The seismic facies interpretation is compared with upscaled borehole image facies associations of two geothermal wells. BHI log data is calibrated with an interpretation of the depositional environment based on cutting analysis Reservoir geometries were derived from an outcrop analog study to better understand the 3D seismic facies interpretation and to construct the conceptual depositional model of the Upper Jurassic carbonates. This technique is commonly used in hydrocarbon exploration but is not yet adapted to geothermal projects, which are often based on little data, smaller company sizes, tight budgets, and limited access to specialized geomodelling software and experience. The approach of using 3D seismic attribute analysis presented in this study provides a quantitative subsurface model of geothermal reservoir facies in the Freiham geothermal field. It is quick and straightforward and can easily be applied in the exploration workflow for similar fields and reservoirs.
Biological control of cabbage head rot (Sclerotinia sclerotiorum) by Coniothyrium minitans
Authors: Sivagnanapazham K. , Karthikeyan M. , Raguchander T. , Swarna Priya R. , Kamalakannan A. 
Published: November 2022

AbstractBackgroundSclerotinia sclerotiorumis the causal agent of white mould, stem and head rot diseases on a wide variety, including cabbage in the field and storage. Control of this pathogen by using commercial disease management methods is extremely difficult. Therefore, this study was performed to identify the potential biological control agent.ResultsThe antagonist fungal isolates, a mycoparasite ofS. sclerotiorum, were isolated and described as KET Cm1, PAL Cm 2 and TDK Cm 3. They were subjected to morphological and microscopic observation. The growth of antagonist fungal isolates on different media revealed that PDA and half-strength Czapek dox agar medium showed the maximum mycelial growth (28.67 and 28.33 mm) and pycnidial production in the PDA medium. The studies on pH and temperature found that growth and sporulation of the antagonist fungal isolates were optimum at pH 5.5 (34 mm) and 20 °C. The molecular confirmation of antagonist fungal isolates was carried out using ITS 1 and ITS 4 primers, which target 18S-28S rRNA gene fragment. The isolates were partially sequenced and showed that more than 99% identity withConiothyrium minitansalready exist in the NCBI database. The accession numbers (MW093134, MW111282 and MW136938) were obtained for all the three isolates and also confirmed using specific primers Cm sp 1F and Cm sp 1R. Among the tested isolates, the antagonistic activity ofC. minitansTDK Cm 3 showed the maximum mycelial growth inhibition of 48.8%S. sclerotiorumand was used for further studies. Penetration and formation of appressoria on the hyphae ofS. sclerotiorumbyC. minitansisolate TDK Cm 3 were observed through the scanning electron microscope. The ethyl acetate fractions of TDK CM 3 isolate were evaluated againstS. sclerotiorumby agar well diffusion assay, paper disc assay and poison food technique in vitro. Through GC–MS analysis, the effective antifungal compounds were identified.ConclusionThe present study focused on the identification and characterization of effectiveConiothyriumisolates as eco-friendly, integrated disease management strategies against cabbage head rot disease.
Outcomes of Immune Checkpoint Inhibitor Administration in Hospitalized Patients With Solid Tumor Malignancies
Authors: Patel Ami K. , Duperreault Megan F. , Pandya Chintan J. , Glotzbecker Brett , Leblebjian Houry , Simmons Justin , Dougherty David 
Published: November 2022

PURPOSE: More oncologists desire to treat their patients with immune checkpoint inhibitors (ICIs) in the inpatient setting as their use has become more widespread for numerous oncologic indications. This is cost-prohibitive to patients and institutions because of high drug cost and lack of reimbursement in the inpatient setting. We sought to examine current practice of inpatient ICI administration to determine if and in which clinical scenarios it may provide significant clinical benefit and therefore be warranted regardless of cost. METHODS: We conducted a retrospective chart review of adult patients who received at least one dose of an ICI for treatment of an active solid tumor malignancy during hospitalization at a single academic medical center between January 2017 and June 2018. Patient, disease, and admission characteristics including mortality data were examined, and cost analysis was performed. RESULTS: Sixty-five doses of ICIs were administered to 58 patients during the study period. Nearly 40% and 80% of patients died within 30 days and 180 days of ICI administration, respectively. There was a trend toward longer overall survival in patients with good prognostic factors including positive programmed death-ligand 1 (PD-L1) expression or microsatellite instability-high (MSI-H) status. Slightly over 70% of patients were discharged within 7 days of ICI administration. The total cost of inpatient ICI administration over the 18-month study period was $615,016 US dollars. CONCLUSION: Inpatient ICI administration is associated with high costs and poor outcomes in acutely ill hospitalized patients with advanced solid tumor malignancies and therefore should largely be avoided. Careful discharge planning to expedite outpatient treatment after discharge will be paramount in ensuring patients with good prognostic features who will benefit most from ICI therapy can be promptly treated in the outpatient setting as treating very close to discharge in the inpatient setting appears to be unnecessary, regardless of tumor features.
Resonances and near field heat transfer of finite structures
Authors: Chui S. T. , Lin Zhifang , Zi Jian 
Published: November 2022

Abstract
We describe a formulation for near field heat transfer for a finite size system so that the heat conductance can be expressed as sums of contributions from the resonances of the combined structure of the “receiver” and the “source”. Our work opens the door to investigating near field heat transfer between finite systems and in particular metamaterials whose resonances have been well studied. We illustrated our results with an analytically tractable example of energy transfer between two split ring resonantors separated by a distance d on top of each other. When the cuts of the two rings are opposite each other, the heat conductance is smaller than when the cuts of the two rings are on top of each other. This result can only come from a finite system calculation.
Cranium growth, patterning and homeostasis
Authors: Ang Phillip S. , Matrongolo Matt J. , Zietowski Maeson L. , Nathan Shelby L. , Reid Russell R. , Tischfield Max A. 
Published: November 2022

ABSTRACT
Craniofacial development requires precise spatiotemporal regulation of multiple signaling pathways that crosstalk to coordinate the growth and patterning of the skull with surrounding tissues. Recent insights into these signaling pathways and previously uncharacterized progenitor cell populations have refined our understanding of skull patterning, bone mineralization and tissue homeostasis. Here, we touch upon classical studies and recent advances with an emphasis on developmental and signaling mechanisms that regulate the osteoblast lineage for the calvaria, which forms the roof of the skull. We highlight studies that illustrate the roles of osteoprogenitor cells and cranial suture-derived stem cells for proper calvarial growth and homeostasis. We also discuss genes and signaling pathways that control suture patency and highlight how perturbing the molecular regulation of these pathways leads to craniosynostosis. Finally, we discuss the recently discovered tissue and signaling interactions that integrate skull and cerebrovascular development, and the potential implications for both cerebrospinal fluid hydrodynamics and brain waste clearance in craniosynostosis.
Development of an emergency airway response system for COVID-19 at a tertiary care hospital in resource limited country
Authors: Shamim Faisal , Khan Muhammad Faisal , Samad Khalid , Latif Asad 
Published: November 2022

The ongoing coronavirus (COVID-19) infection causes severe respiratory dysfunction and has become an emergent issue for worldwide healthcare due to highly transmissible and contagious nature. Aerosol generating procedures such as tracheal intubation is of particularly high risk. This mandates some advice on processes and techniques required to protect staff and uniform approach during airway management. We hereby share our experience in development of an emergency response system to deal with COVID airway management at a frontline hospital which particularly consider the local demands and resources. This includes a change in working dynamics with 24/7 consultant coverage for emergent or urgent tracheal intubation of COVID patients at non-operating room locations. Other steps include prepackaging intubation baskets, availability of videolaryngoscope, standard personal protective equipment including powered air purifying respirator, and use of modified intubation checklist.
doi: https://doi.org/10.12669/pjms.39.1.5689
How to cite this: Shamim F, Khan MF, Samad K, Latif A. Development of an emergency airway response system for COVID-19 at a tertiary care hospital in resource limited country. Pak J Med Sci. 2023;39(1):---------. doi: https://doi.org/10.12669/pjms.39.1.5689
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Knowledge, attitude, and uptake of human papilloma virus vaccine and associated factors among female preparatory school students in Bahir Dar City, Amhara Region, Ethiopia
Authors: Lakneh Etenesh Adela , Mersha Eleni Admassu , Asresie Melash Belachew , Belay Habtamu Gebrehana 
Published: November 2022

Background
The human papillomavirus vaccine is one of the main preventative measures for cervical cancer. However, global vaccine uptake is low; the problem is particularly acute in low and middle-income countries. The purpose of this study is to assess female preparatory school students’ knowledge, attitude, and uptake of the human papillomavirus vaccine and associated factors in Bahir Dar City, Ethiopia.

Methods
Institutional-based cross-sectional study was conducted among 633 female preparatory school students in Bahir Dar city from March 1–30, 2021. Participants were selected using the multistage sampling technique. Data were collected using a structured self-administered questionnaire and entered into Epi-data and exported to SPSS for analysis. Binary and multivariable logistic regression analyses were done using an odds ratio with a 95% confidence interval. Finally-value < 0.05 was considered significant in multivariable analysis.

Result
The proportion of Human Papillomavirus (HPV) vaccine uptake, knowledge of the vaccine, and respondents’ attitudes toward the vaccine were 45.3% (95% CI = 41.6–49.4%), 58.1% (95% CI = 54.4–61.9%), and 16% (95% CI = 13.2–19.5%), respectively. Having a history of sexual contact AOR = 2.80 (95% CI = 1.64–4.76), hearing about HPV infection AOR = 1.59 (95% CI = 1.13–2.24), and having a positive attitude toward HPV vaccine AOR = 1.46 (95% CI = 1.03–2.08) were significantly associated with knowledge about the HPV vaccine. Discussion of reproductive health issues with family AOR = 2.558 (95%CI = 1.800–3.636), and having good knowledge about HPV vaccine AOR = 3.571(95%CI = 2.494–5.113) were associated with a positive attitude toward the HPV vaccine. Good knowledge AOR = 2.36(95%CI = 1.48–3.76) and a positive attitude toward HPV vaccine AOR = 2.87(95%CI = 1.70–4.85) were strongly associated with HPV vaccine utilization.

Conclusion
In this study, there was a very low uptake of HPV vaccination among female students, and only a small proportion of them had good knowledge of the HPV vaccine and a favorable attitude toward the HPV vaccine.
»Die Welt von Blut und Wunden«: Dantes Kriegsdichtung aus der Perspektive Karl Vosslers und Erich Auerbachs
Authors: Bank Jörg Hartwig 
Published: November 2022

Riassunto
I traumi causati dai conflitti bellici ai quali l’autore prese parte in prima persona vengono trattati soprattutto nel canto XXVIII dell’Inferno, nel dialogo tra Dante e Bertran de Born, ›poeta delle armi‹ provenzale. Karl Vossler e Erich Auerbach sono due grandi esegeti danteschi nella Germania della prima metà del Novecento, entrambi sopravvissuti alla Prima guerra mondiale. Nella sua interpretazione della Commedia, Vossler approfondisce la questione dell’influenza stilistica che Born poté avere su Dante ben più di Auerbach, che nel suo libro su Dante include soltanto un breve cenno al troubadour. Nel dipinto »Dante e Virgilio in trincea« del 1915, infine, il pittore tedesco-ucraino-francese Franz Roubaud illustra il canto XXVIII dell’Inferno rivisitando i personaggi di Dante e Virgilio come dei testimoni della Prima guerra mondiale.
Zur deutschen Danteforschung im 19. Jahrhundert
Authors: Bartuschat Johannes 
Published: November 2022

Riassunto
Questo contributo tratta degli studi danteschi in lingua tedesca nel XIX secolo. Anche se tutta l’Europa riscopre Dante con entusiasmo a partire dal 1800, la Germania può essere considerata, insieme all’Italia, come il paese in cui ha inizio la ricerca scientifica sulla sua opera, sulla sua vita e sulla sua epoca e in cui si gettano le basi per gli studi del XX secolo. Attraverso l’analisi di alcuni studi significativi il saggio cerca di illustrare i principali temi e orientamenti della ricerca dantesca del periodo in lingua tedesca. Le ricerche sul contesto storico di Dante e l’analisi del suo pensiero politico si rivelano temi particolarmente importanti, ai quali vengono dedicati numerosi studi approfonditi.