bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lidocaine infusions for refractory chronic migraine: a retrospective analysis
Authors: Schwenk Eric S , Walter Aaron , Torjman Marc C , Mukhtar Sarah , Patel Harsh T , Nardone Bryan , Sun George , Thota Bhavana , Lauritsen Clinton G , Silberstein Stephen D 
Published: May 2022

IntroductionPatients with refractory chronic migraine have poor quality of life. Intravenous infusions are indicated to rapidly ‘break the cycle’ of pain. Lidocaine infusions may be effective but evidence is limited.MethodsThe records of 832 hospital admissions involving continuous multiday lidocaine infusions for migraine were reviewed. All patients met criteria for refractory chronic migraine. During hospitalization, patients received additional migraine medications including ketorolac, magnesium, dihydroergotamine, methylprednisolone, and neuroleptics. The primary outcome was change in headache pain from baseline to hospital discharge. Secondary outcomes measured at the post-discharge office visit (25–65 days after treatment) included headache pain and the number of headache days, and percentage of sustained responders. Percentage of acute responders, plasma lidocaine levels, and adverse drug effects were also determined.ResultsIn total, 609 patient admissions met criteria. The mean age was 46±14 years; 81.1% were female. Median pain rating decreased from baseline of 7.0 (5.0–8.0) to 1.0 (0.0–3.0) at end of hospitalization (p<0.001); 87.8% of patients were acute responders. Average pain (N=261) remained below baseline at office visit 1 (5.5 (4.0–7.0); p<0.001). Forty-three percent of patients were sustained responders at 1 month. Headache days (N=266) decreased from 26.8±3.9 at baseline to 22.5±8.3 at the post-discharge office visit (p<0.001). Nausea and vomiting were the most common adverse drug effects and all were mild.ConclusionLidocaine infusions may be associated with short-term and medium-term pain relief in refractory chronic migraine. Prospective studies should confirm these results.
Healthcare utilisation and expenditures attributable to current e-cigarette use among US adults
Authors: Wang Yingning , Sung Hai-Yen , Lightwood James , Yao Tingting , Max Wendy B 
Published: May 2022

AimsThis study estimated annual healthcare expenditures attributable to current e-cigarette use among US adults, including current exclusive and dual/poly e-cigarette use.MethodsAnalysing the 2015–2018 National Health Interview Survey data, we estimated the impacts of e-cigarette use on healthcare utilisation among adults aged 18+ years. Healthcare utilisation outcomes were hospital nights, emergency room (ER) visits, doctor visits and home visits. Current e-cigarette use was categorised as exclusive and dual/poly e-cigarette use. The econometric model included two equations: health status as a function of e-cigarette use and other independent variables, and healthcare utilisation as a function of health status, e-cigarette use, and other independent variables. Using an ‘excess utilisation’ approach, we multiplied the e-cigarette-attributable fraction derived from the model by annual health expenditures to calculate healthcare expenditures attributable to current exclusive and dual/poly e-cigarette use, the sum of which were expenditures attributable to all current e-cigarette use.ResultsCurrent exclusive and dual/poly e-cigarette use, with 0.2% and 3.5% prevalence in 2015–2018, were associated with higher odds of reporting poor health status than never tobacco users. Poor health status was associated with higher odds of using the four healthcare services and a greater number of ER and doctor visits. Annual healthcare expenditures attributable to all current e-cigarette use was $15.1 billion ($2024 per user) in 2018, including $1.3 billion attributable to exclusive e-cigarette use ($1796 per user) and $13.8 billion attributable to dual/poly e-cigarette use ($2050 per user).ConclusionAdult current e-cigarette use was associated with substantial excess healthcare utilisation and expenditures.
Scaling behaviour of braided active channels: a Taylor’s power law approach
Authors: De Bartolo Samuele , Rizzello Stefano , Ferrari Ennio , Frega Ferdinando , Napoli Gaetano , Vitolo Raffaele , Scaraggi Michele , Fallico Carmine , Severino Gerardo 
Published: May 2022

AbstractAt a channel (reach) scale, braided channels are fluvial, geomorphological, complex systems that are characterized by a shift of bars during flood events. In such events water flows are channeled in multiple and mobile channels across a gravel floodplain that remain in unmodified conditions. From a geometrical point of view, braided patterns of the active hydraulic channels are characterized by multicursal nature with structures that are spatially developed by either simple- and multi-scaling behavior. Since current studies do not take into account a general procedure concerning scale measurements, the latter behavior is still not well understood. The aim of our investigation is to analyze directly, through a general procedure, the scaling behavior of hydraulically active channels per transect and per reach analyzed. Our generalized stochastic approach is based on Taylor’s law, and the theory of exponential dispersion distributions. In particular, we make use of a power law, based on the variance and mean of the active channel fluctuations. In this way we demonstrate that the number of such fluctuations with respect to the unicursal behavior of the braided rivers, follows a jump-process of Poisson and compound Poisson–Gamma distributions. Furthermore, a correlation is also provided between the scaling fractal exponents obtained by Taylor’s law and the Hurst exponents.
Oxidative Potential and Nanoantioxidant Activity of Flavonoids and Phenolic Acids in Sophora flavescens
Authors: Zhu Yujie , Wang Wenle , Ruan Renyu , Chen Jinquan 
Published: May 2022

In order to further develop and utilize the rutin from Sophora japonica, the contents of total phenolic acids and flavonoids in rutin extracts from different parts of Sophora flavescens were determined, and their antioxidant activities were compared, and the basis of antioxidative activity of Sophora flavescens nanometers was discussed. The experiment found that the total flavonoid content of each extract of Huai Mi was in the range of 5.70–61.55 mg/g, the total phenolic acid content was in the range of 4.07–19.10 mg/g, and the total flavonoid and phenolic acid content of the ethyl acetate extract was significantly higher than other extracts. Its reducing power, light free radicals, DPPH, ABTS+, and scavenging rate are also significantly higher than n-butanol, petroleum ether, and aqueous extracts.

∗

The cleaning ability IC50 values of DPPH· are (0.321

±

0.0026), (0.213

±

0.0010), and (0.169

±

0.0014) mg/mL. The effective components of Sophora japonica are initially separated after the solvent extraction of each phase. The relative content and nanoantioxidant activity of total flavonoids and phenolic acids in the ethyl acetate phase extraction part were significantly stronger than those in the total extract and other extraction parts, and the antioxidant capacity was effectively related to the dose. The flavonoids and phenolic acids in Sophora japonica are closely related to its antioxidant capacity.
The Impact of a Multimodal Sport Science-Based Prehabilitation Program on Clinical Outcomes in Abdominal Cancer Patients: A Cohort Study
Authors: Wooten Savannah V. , Wolf J. Stuart , Mendoza Diana , Bartholomew John B. , Stanforth Philip R. , Stanforth Dixie , Tanaka Hirofumi , Fleming R.Y. Declan 
Published: May 2022

Background The potential for prehabilitation programs to impact clinical outcomes is uncertain in abdominal cancer patients due to the short window of time to intervene and the weakened state of the patients. To improve the effectiveness of prehabilitation intervention, a multimodal sports science approach was implemented. Methods Prior to cancer-related surgery, 21 patients participated in a 4-week exercise and nutrition prehabilitation program comprised of blood flow restriction exercise (BFR) and a sports nutrition supplement. Retrospective data of 71 abdominal cancer patients who underwent usual preoperative care was used as a comparator control group (CON). At 90 days post-surgery, clinical outcomes were quantified. Results Prehabilitation was associated with a shorter length of hospital stay ( P = .02) with 5.5 fewer days (4.7 ± 2.1 vs 10.2 ± 1.2 days in CON) and decreased incidence of any complications ( P = .03). Prehabilitation was not related to incidence of serious complications ( P = .17) or readmission rate ( P = .59). The prehabilitation group recorded 58% more steps on day 5 after surgery ( P = .043). Discussion A 4-week home-based prehabilitation program composed of BFR training and sports nutrition supplementation was effective in reducing postoperative complications and length of hospital stay in older patients with abdominal cancer. ClinicalTrials.gov Identifier: NCT04073381.
When “Stay” Sutures Stay
Authors: Stanisce Luke , Solomon Donald H. , Koshkareva Yekaterina 
Published: May 2022

Chronic airway foreign bodies represent a rare and challenging entity faced by otolaryngologists. Herein, we describe the case of an adult woman found to have a 17 cm-long internalized tracheostomy stay suture retained 2 years after decannulation. Thorough evaluation and contingency planning allowed for safe and successful removal of this novel airway foreign body. The selective use of stay sutures in adult tracheostomies and proper peri-operative care may have prevented its incidence.
Demography as Destiny: Explaining the Turnover of Alternatively Certified Mathematics Teachers in Hard-to-Staff Schools
Authors: Grant Ashley A. , Brantlinger Andrew M. 
Published: May 2022

Background: To stem the tide of teacher turnover and prevent shortages, teacher turnover interventions and policies often focus on new and novice teachers because evidence suggests that teacher turnover is particularly high among these teachers. In addition, researchers continue to investigate the root causes of the high teacher turnover observed in many low-income, high-minority schools and whether this is due more to school demographics or poor working conditions. Purpose: This article examines New York City Teaching Fellows (NYCTF) teachers’ risk of leaving their first school in their first 9 years. It both describes the patterns in leaving and examines how school demographics and school climate predict these leaving patterns. Participants: The study follows 608 teachers: two cohorts of secondary mathematics NYCTF teachers who entered the classroom in New York City in 2006 or 2007. Research Design: This is a quantitative study of survey and retention data that were collected as part of a longitudinal research project on NYCTF mathematics teachers. Data Analysis: We use an event history analysis (including a life table and hazard function graphs) to describe patterns in teachers’ timing of leaving their first school. We also use a discrete time hazard model to estimate the relative relationships between the predictors of interest (school demographics and school climate) and teacher turnover. Results: The findings from this study provide evidence against the general hypothesis in the field that teachers leave their first schools at the highest rate during their first 1 to 3 years. Second, we also found that the turnover of alternatively certified teachers who began in low-income, high-minority urban schools was driven by both student demographics and school climate conditions, including teacher collegiality and student behavior. Third, we found evidence to support our hypothesis that teachers’ individual perceptions of their school environment are stronger drivers of their turnover compared with the perceptions of their colleagues. Conclusion: The results from this study add to our understanding about the timing of teacher turnover among secondary mathematics NYCTF teachers, illustrating that teacher turnover may remain higher later in beginning teachers’ careers than currently assumed. This suggests that teachers in Years 3 to 5 in their careers may be good targets for supports. Our findings support the theory that improving school climate can help retain teachers but also provide a cautionary tale for a complete focus on school climate; stemming teacher turnover may require addressing larger economic forces (e.g., the global trend toward temporary work) and more insidious social forces, such as structural racism and inequality.
Walking the Talk: Employing Culturally Relevant Pedagogy in Teacher Education
Authors: Kondo Chelda Smith 
Published: May 2022

Background: Teacher education programs (TEPs) have a mandate to prepare teachers qualified to educate culturally and linguistically diverse student populations. In addition, the demographic imperative compels TEPs to recruit preservice teachers from underrepresented communities; yet, just as youth of color are marginalized in schools, so too are teacher candidates of color (TCCs) marginalized in TEPs. Just as conventional TEP curriculums fail to decenter dominant social groups, so too do many teacher educators fail to enact asset-based pedagogy. A teacher quality gap and culturally rooted disenfranchisement persist. Purpose: I examine how TCCs are prepared to teach critically in demographically pluralistic schools and how one teacher educator of color attempts to close the teacher quality gap with a diverse preservice teacher cohort through the application of culturally relevant pedagogy (CRP). Although asset pedagogies are widely accepted as best practice in P–12 classrooms, there exists a dearth of research on their impact on postsecondary spaces. Moreover, multicultural education scholarship focused on the experiences of TCCs is limited. Research Design: Drawing from a larger critical ethnographic study of two diversity courses in an urban TEP, this article explicates one teacher educator’s application of CRP. I utilize the core tenets of CRP—academic achievement, cultural competence, and sociopolitical consciousness—to bridge the gap between theory and practice through illustrations of intentional critical pedagogy. Data were analyzed from field notes, interviews of students and faculty, course assignments, readings, syllabi, evaluations, and other relevant artifacts. Results: Findings indicate that modeling CRP is paramount to developing culturally relevant pedagogues and that making known the interdependence of CRP’s three fundamental pillars is central to transformative learning experiences for preservice teachers. Although challenging, CRP at the postsecondary level is an achievable endeavor that requires increased faculty innovation, reflexivity, and humility. Conclusion: The project offers practical applications of CRP that are adaptable to most teacher preparation courses. Recommendations include a call for more studies that examine the use of asset-based pedagogies in higher education, especially in TEPs.
A Machine-Learning Approach for Estimating Subgroup- and Individual-Level Treatment Effects: An Illustration Using the 65 Trial
Authors: Sadique Zia , Grieve Richard , Diaz-Ordaz Karla , Mouncey Paul , Lamontagne Francois , O’Neill Stephen 
Published: May 2022

Personalizing treatment recommendations or guidelines requires evidence about the heterogeneity of treatment effects (HTE). Machine-learning (ML) approaches can explore HTE by considering many covariates, including complex interactions between them. Causal ML approaches can avoid overfitting, which arises when the same dataset is used to select covariate by treatment interaction terms as to make inferences and reduce reliance on the correct specification of fixed parametric models. We investigate causal forests (CF), a ML method based on modified decision trees that can estimate subgroup- and individual-level treatment effects, without requiring correct prespecification of the effect model. We consider CF alongside parametric approaches for estimating HTE, within the 65 Trial, which evaluates the effect of a permissive hypotension strategy versus usual care on 90-d mortality for critically ill patients aged 65 y or older with vasodilatory hypotension. Here, the CF approach provides similar estimates of treatment effectiveness for prespecified and post hoc subgroups to the parametric approach, and the results of a test for overall HTE show weak evidence of heterogeneity. The CF estimates of individual-level treatment effects, the expected effects of treatment for individuals in subpopulations defined by their covariates, suggest that the permissive hypotension strategy is expected to reduce 90-d mortality for 98.7% of patients but with 95% confidence intervals that include zero for 71.6% of patients. A ML approach is then used to assess the patient characteristics associated with these individual-level effects, and to help target future research that can identify those patient subgroups for whom the intervention is most effective. Highlights This article examines a causal machine-learning approach, causal forests (CF), for exploring the heterogeneity of treatment effects, without prespecifying a specific functional form. The CF approach is considered in the reanalysis of the 65 Trial and was found to provide similar estimates of subgroup effects to using a fixed parametric model. The CF approach also provides estimates of individual-level treatment effects that suggest that for most patients in the 65 Trial, the intervention is expected to reduce 90-d mortality but with wide levels of statistical uncertainty. The study illustrates how individual-level treatment effect estimates can be analyzed to generate hypotheses for further research about those patients who are likely to benefit most from an intervention.
Reproducibility of MRI in the diagnosis of meniscal ramp lesions: an inter-observer study
Authors: Menéndez Sara Escoda , González Pedro García , Morís Ana Rosa Meana , Soto Miguel del Valle , Fernández Antonio Maestro 
Published: May 2022

Background Meniscal ramp lesions have gained much prominence in recent years due to a significant increase in their diagnosis and their important biomechanical involvement in the knee. A new proposed classification of these lesions has recently been published. Purpose To evaluate the reproducibility of the new classification of meniscal ramp lesions recently published using magnetic resonance imaging (MRI). Material and Methods A total of 249 post-traumatic knee MRI studies were evaluated by three musculoskeletal radiologists independently. Patients with an anterior cruciate ligament (ACL) tear on MRI in addition to a recent history of trauma to the knee for <12 months were included in the study, for a total of 95. We carried out an inter-observer concordance study to analyze whether the new classification is reproducible to detect meniscal ramp lesions and to classify them into their different types. Results Among our study cohort of 95 patients, we found 47 (49.5%) ramp lesions. In the inter-observer study, we obtained a good concordance (k = 0.733) in the detection of these lesions and an excellent one (k = 0.843) when the type of lesion is described. Conclusion This study demonstrates that the new classification of meniscal ramp lesions has good reproducibility on MRI.
Social-Ecological Correlates of Social Isolation as a Structural Indicator of Social Connectedness Among Young Adult U.S. Males
Authors: Rovito Kathy E. , Herring R. Patti , Beeson W. Lawrence , Gamboa-Maldonado Thelma , Lee Jerry W. 
Published: May 2022

Purpose We examined the intrapersonal, interpersonal, community, and societal correlates of a structural indicator of social connectedness (ie, social isolation) among a sample of young adult U.S. males Design Cross-sectional. Setting: Online survey. Subjects Males (n = 495) aged 18-25 years residing in the U.S. Measures Social isolation was assessed as an index measure of social integration (inverse scored). The correlates consisted of the following variables: 1) intrapersonal (eg, social-demographic characteristics), 2) interpersonal (eg, adverse childhood experiences; marital status), 3) community (eg, county-level mental distress rates), and 4) societal (eg, how powerful is society’s image of the ‘masculine man’). Analysis Four-block hierarchical regression. Results The intra- and interpersonal variables significantly shared 17% and an incremental 5%, respectively, of the explained variance in social isolation. Several intra- (eg, financial vulnerability β = -2.76, [95% CI: -4.40, -1.13]) and inter-personal (ie, childhood household dysfunction β = -.66, [95% CI: -1.18, -.14]) factors were significantly associated with greater social isolation. Four intrapersonal factors (eg, gay or bisexual β = 2.31, [95% CI: .29, 4.33]) were significantly associated with lower social isolation. Conclusions The current study’s findings have important implications for understanding and shaping social connectedness in young adult U.S. males, with micro-level influences potentially being most important in predicting social isolation in this population.
Penetration resistance properties of glass fiber reinforced polypropylene composites with different ply angles
Authors: Zou Guangping , Wu Songyang , Chang Zhongliang , Liu Yuhang , Wang Xuan 
Published: May 2022

This paper mainly studies the dynamic response of composites with glass fiber as reinforcement and polypropylene resin as matrix under high-speed projectile penetration. The penetration effects of fiber unidirectional ply cross-ply and quasi-isotropic ply laminate were studied by using penetration velocities of 100–500 m/s. The effects of ply angle on ballistic limit velocity, target energy absorption rate and corresponding failure mode are analyzed. The correctness of the simulation model is verified by comparative experiments, and the ply angle of glass fiber reinforced polypropylene (GF/PP) composites is optimized. The results show that the energy absorption efficiency of the three kinds of laminated plates gradually decreases with the increase of the projectile incident velocity, and with the increase of the velocity, the absorption rate of the target plate gradually decreases tends to the same constant. The laminated plates with complex ply angles are simulated and analyzed, and the optimization results show that the ballistic limit velocity of fiber-reinforced composite laminates with ply angle of 30° is the highest.
Fluctuating Voriconazole Concentrations during Extracorporeal Membrane Oxygenation
Authors: Vu Truong , Feih Joel , Juul Janelle 
Published: May 2022

Background Patients requiring extracorporeal membrane oxygenation (ECMO) demonstrate complex drug pharmacokinetics due to alterations in clearance and volume of distribution, necessitating close therapeutic drug monitoring. Case Report: A 19-year-old Caucasian female with no past medical history was transferred from an outside hospital and admitted to the intensive care unit for acute respiratory distress syndrome secondary to a fresh water drowning event. The patient decompensated, requiring veno-arterial ECMO, which was subsequently changed to veno-venous ECMO. She was diagnosed with a Scedosporium apiospermum fungal pneumonia and was started on voriconazole. Throughout the course of antifungal therapy, the patient’s voriconazole concentrations were labile, ranging from subtherapeutic, requiring dose increases to twice the labeled therapeutic dose, followed by subsequent supratherapeutic concentrations, requiring dose reductions. Conclusion: Our findings demonstrate how voriconazole drug concentrations can be unpredictable when administered during ECMO and the importance of close monitoring of drug concentrations. More studies are needed to provide sufficient guidance on administering voriconazole in critically ill patients receiving ECMO.