bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blockchain empowers supply chains: challenges, opportunities and prospects
Authors: Li Yongjian , Chen Ting 
Published: December 2022

Purpose
The advantages of blockchain technology are being widely discussed by academics, the business community and government, because blockchain can promote data sharing, optimise business processes, reduce operation costs, improve collaborative efficiency and build credible systems. The supply chain is becoming a key area for the application of blockchain technology. However, few studies have discussed the effect of such emerging technologies on the supply chain in depth. Therefore, this paper aims to analyse how blockchain empowers supply chain and promotes supply chain management.

Design/methodology/approach
Based on a review of relevant literature and blockchain applications in practice, this paper analyses the development and research status of blockchain technologies. In addition, considering the different operational processes within the supply chain, the authors discuss the opportunities and challenges of blockchain technologies, such as the transparency of supply, intelligent manufacturing, the security of logistics, the platformisation of sales and the ecology of governance.

Findings
The authors find that information sharing, information traceability and trust establishment are the key categories of research achievements and applications of supply chain management. The central issues for blockchain researchers are the authenticity of transaction data, the traceability of long supply chains and the establishment of trust for all participants.

Originality/value
From the practical and theoretical perspectives, this paper shows the development of blockchain technologies to clarify the challenges, opportunities and prospects. This paper elucidates and facilitates the development of emerging interdisciplinary research and the practice of supply chain.
Talent designation as a mixed blessing: Short‐ and long‐term employee reactions to talent status
Authors: Tyskbo Daniel , Wikhamn Wajda 
Published: December 2022

AbstractTalent management (TM) continues to attract considerable attention from both practitioners and academics. Existing research investigating employee reactions to being awarded talent status has not elucidated the processual nature of such reactions. This study extends TM research by providing a nuanced understanding of how employees react to talent designation over time and why. Specifically, it distinguishes between short‐ and long‐term reactions and uses the lenses of psychological contract (PC) theory and social identity theory (SIT) to unpack mechanisms underlying immediate positive, and delayed negative, employee reactions to talent designation. Results from qualitative analysis of interviews with talents in three organizations show how—as time elapsed and no identity‐relevant events occurred—perceptions of “talent emptiness” and “indeterminacy” developed. The study unfolds the complex interaction between SIT and PC (including breach and violation) to explain talents’ evolving reactions over time. As such, it contributes to TM literature by providing a nuanced understanding of the processes underlying employee reactions in exchanges involving socioemotional resources.
Haploid gynogens facilitate disomic marker development in paleotetraploid sturgeons
Authors: Flamio Richard , Swift Dominic G. , Portnoy David S. , Chojnacki Kimberly A. , DeLonay Aaron J. , Powell Jeffrey , Braaten Patrick J. , Heist Edward J. 
Published: December 2022

AbstractAcipenseriformes (sturgeons and paddlefishes) are of substantial conservation concern, and development of genomic resources for these species is difficult due to past whole genome duplication. Development of disomic markers for polyploid organisms can be challenging due to difficulty in resolving alleles at a single locus from those among duplicated loci. In this study, we detail the development of disomic markers for the endangered pallid sturgeon (Scaphirhynchus albus) found in North America. One of the strategies for pallid sturgeon conservation is to stock U.S. rivers with offspring of pure pallid sturgeon, but introgression with the sympatric shovelnose sturgeon (S. platorynchus) threatens pallid sturgeon genetic integrity. Currently, 19 microsatellite loci are used to differentiate between both species and their hybrids, but the markers are insufficient to robustly identify backcrosses. We performed double digest restriction site‐associated DNA sequencing (ddRADseq) on shovelnose sturgeon haploid gynogens to produce a reduced‐representation genomic reference. Contiguous sequences that were heterozygous within a haploid individual were flagged as potentially encompassing multiple loci. Approximately 60 individuals of each species from two management units were sequenced, and reads were mapped to the haploid reference to identify single nucleotide polymorphisms (SNPs) at individual loci. The final data set contained 11,082 microhaplotyped loci which offer at least an order of magnitude greater resolution for species discrimination than the current panel of 19 microsatellites. These markers will be used to examine a larger sample of Scaphirhynchus individuals throughout their ranges to determine the extent and trajectory of hybridization.
Incidental diagnosis of pulmonary cryptococcosis by rebiopsy for epidermal growth factor receptor T790M mutation: A case report
Authors: Kobe Hiroshi , Yokoe Shinya , Ishida Tadashi 
Published: December 2022

AbstractCryptococcosis is an invasive fungal infection that can occur in cancer patients. A case of pulmonary cryptococcosis in a patient treated with erlotinib + ramucirumab for epidermal growth factor receptor (EGFR) L858R point mutation‐positive non‐small cell lung cancer is presented. During chemotherapy, a new pulmonary nodule was found and considered progressive disease. Examination of the biopsy specimen taken to identify EGFR T790M mutation incidentally led to the diagnosis of pulmonary cryptococcosis. Three months after taking fluconazole, chest computed tomography showed that the pulmonary nodule had shrunk. New pulmonary nodules during lung cancer treatment require careful attention, not only because of disease progression, but also because of the possibility of infection in an immunocompromised host.
Burkitt lymphoma after solid‐organ transplant: Treatment and outcomes in the paediatric PTLD collaborative
Authors: Afify Zeinab , Orjuela‐Grimm Manuela , Smith Christine Moore , Dalal Mansi , Ford James B. , Pillai Pallavi , Robles Joanna M. , Reddy Sonika , McCormack Sarah , Ehrhardt Matthew J. , Ureda Tonya , Alperstein Warren , Edington Holly , Miller Tamara P. , Rubinstein Jeremy D. , Kavanaugh Madison , Bukowinski Andrew J. , Friehling Erika , Rivers Julie M. , Chisholm Karen M. , Marks Lianna J. , Mason Clinton C. 
Published: December 2022

SummaryBurkitt lymphoma arising in paediatric post‐solid‐organ transplantation‐Burkitt lymphoma (PSOT‐BL) is a clinically aggressive malignancy and a rare form of post‐transplant lymphoproliferative disorder (PTLD). We evaluated 35 patients diagnosed with PSOT‐BL at 14 paediatric medical centres in the United States. Median age at organ transplantation was 2.0 years (range: 0.1–14) and age at PSOT‐BL diagnosis was 8.0 years (range: 1–17). All but one patient had late onset of PSOT‐BL (≥2 years post‐transplant), with a median interval from transplant to PSOT‐BL diagnosis of 4.0 years (range: 0.4–12). Heart (n = 18 [51.4%]) and liver (n = 13 [37.1%]) were the most frequently transplanted organs. No patients had loss of graft or treatment‐related mortality. A variety of treatment regimens were used, led by intensive Burkitt lymphoma‐specific French–American–British/Lymphomes Malins B (FAB/LMB), n = 13 (37.1%), and a low‐intensity regimen consisting of cyclophosphamide, prednisone and rituximab (CPR) n = 12 (34.3%). Median follow‐up was 6.7 years (range: 0.5–17). Three‐year event‐free and overall survival were 66.2% and 88.0%, respectively. Outcomes of PSOT‐BL patients receiving BL‐specific intensive regimens are comparable to reported BL outcomes in immunocompetent children. Multi‐institutional collaboration is feasible and provides the basis of prospective data collection to determine the optimal treatment regimen for PSOT‐BL.
Trajectories of cough without a cold in early childhood and associations with atopic diseases
Authors: Divaret‐Chauveau Amandine , Mauny Frederic , Hose Alexander , Depner Martin , Dalphin Marie‐Laure , Kaulek Vincent , Barnig Cindy , Schaub Bianca , Schmausser‐Hechfellner Elisabeth , Renz Harald , Riedler Josef , Pekkanen Juha , Karvonen Anne M. , Täubel Martin , Lauener Roger , Roduit Caroline , Vuitton Dominique Angèle , von Mutius Erika , Demoulin‐Alexikova Silvia ,   the PASTURE study group
Published: December 2022

AbstractBackgroundAlthough children can frequently experience a cough that affects their quality of life, few epidemiological studies have explored cough without a cold during childhood.ObjectivesThe objective of the study was to describe the latent class trajectories of cough from one to 10 years old and analyse their association with wheezing, atopy and allergic diseases.MethodsQuestions about cough, wheeze and allergic diseases were asked at 1, 1.5, 2, 3, 4, 5, 6 and 10 years of age in the European prospective cohort of Protection against Allergy: STUdy in Rural Environment (PASTURE). Specific IgE assays were performed at 10 years of age. Questions regarding a cough without a cold were used to build a latent class model of cough over time.ResultsAmong the 961 children included in the study, apart from the never/infrequent trajectory (59.9%), eight trajectories of cough without a cold were identified: five grouped acute transient classes (24.1%), moderate transient (6.8%), late persistent (4.8%) and early persistent (4.4%). Compared with the never/infrequent trajectory, the other trajectories were significantly associated with wheezing, asthma and allergic rhinitis. For asthma, the strongest association was with the early persistent trajectory (ORa = 31.00 [14.03–68.51]), which was inversely associated with farm environment (ORa = 0.39 [0.19–0.77]) and had a high prevalence of cough triggers and unremitting wheeze. Late and early persistent trajectories were also associated with food allergy. Atopic sensitization was only associated with the late persistent trajectory.ConclusionLate and early persistent coughs without a cold are positively associated with atopic respiratory diseases and food allergy. Children having recurrent cough without a cold with night cough and triggers would benefit from an asthma and allergy assessment. Growing up on a farm is associated with reduced early persistent cough.
A comprehensive functional analysis on the pathogenesis of novel TSPAN12 and NDP variants in familial exudative vitreoretinopathy
Authors: Zhao Rulian , Dai Erkuan , Wang Shiyuan , Zhang Xiang , He Yunqi , Peng Li , Zhao Peiquan , Yang Zhenglin , Yang Mu , Li Shujin 
Published: December 2022

AbstractFamilial exudative vitreoretinopathy (FEVR) is an inherited blinding disorder; however, the known FEVR‐associated variants account for approximately only 50% cases. Currently, the pathogenesis of most reported variants is not well studied, we aim to identify novel variants from FEVR‐associated genes and perform a comprehensive functional analysis to uncover the pathogenesis of variants that cause FEVR. Using targeted gene panel and Sanger sequencing, we identified six novel and three known variants in TSPAN12 and NDP. These variants were demonstrated to cause significant inhibition of Norrin/β‐catenin pathway by dual‐luciferase reporter assay and western blot analysis. Structural analysis and co‐immunoprecipitation revealed compromised interactions between missense variants and binding partners in the Norrin/β‐catenin pathway. Immunofluorescence and subcellular protein extraction were performed to reveal the abnormal subcellular trafficking. Additionally, over‐expression of TSPAN12 successfully enhanced the Norrin/β‐catenin signaling activity by strengthening the binding affinity of mutant Norrin with FZD4 or LRP5. Together, these observations expanded the spectrum of FEVR‐associated variants for the genetic counseling and prenatal diagnosis of FEVR, as well providing a potential therapeutic strategy for the treatment of FEVR.
Does board gender diversity reduce workplace sexual harassment?
Authors: Au Shiu‐Yik , Tremblay Andréanne , You Leyuan 
Published: December 2022

AbstractResearch Question/IssueWe contrast the predictions of gender socialization theory and “fem‐power washing” (deceptively positioning as a firm promoting female empowerment without any tangible actions) to investigate whether promoting female directors on the board of directors associates with a reduction in the prevalence of firm‐level workplace sexual harassment (SH).Research Findings/InsightsWe estimate the incidence rate of SH through textual analysis of US employees' job reviews published online during the period 2011–2021. We find that an increase of one female director is associated with a 21.81% decrease in workplace SH and that firms with high board gender diversity synchronize the reduction in SH with improved social policies (e.g., policies to better employee relations, health and safety, or diversity challenges). Our results do not support the fem‐power washing theory but rather imply that nominating female directors may have a profound impact on the firm's ethical culture.Theoretical/Academic ImplicationsThis study validates the ethical dimension of corporate governance: Nominating female directors impacts a firm harassment culture and, by extension, a firm's ethical and corporate culture. This study adds to the governance literature that debates the merits of board gender diversity by highlighting an oft‐ignored channel through which board diversity affects firm value: ethics and corporate culture.Practitioner/Policy ImplicationsFor boards of directors, having more female directors can curb workplace SH, a behavior that is associated with a severe and lasting negative effect on firm value. For practitioners, regulators, and the business community, this study reinforces the merits of aiming towards more gender‐balanced boards.
Ductal differentiation: A rare phenomenon in Merkel cell carcinoma
Authors: Vanderbeck Kaitlin , Cho Woo Cheal , Aung Phyu P. , Ivan Doina , Rothrock Aimi T. , Torres‐Cabala Carlos A. , Prieto Victor G. , Curry Jonathan L. , Nagarajan Priyadharsini 
Published: December 2022

AbstractMerkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma that may occasionally present divergent histopathologic features. We present two cases of MCC demonstrating ductal differentiation, one on the lower lip of an 81‐year‐old man and another on the right forearm of a 67‐year‐old man. The histopathologic features included TTF1‐negative, infiltrative, high‐grade basaloid tumor with paranuclear punctate positivity for cytokeratin (CK) 20 and synaptophysin. Rare luminal structures lined by atypical epithelioid cells positive for CEA and CK19 were noted, confirming the presence of ductal differentiation. Although the ductal differentiation is unusual, other histopathologic features and the immunohistochemical profile supported the diagnosis of MCC. Like most divergent features, ductal differentiation is rare in MCC and typically constitutes a very small proportion of the tumor, and is therefore under‐recognized. Although the clinical significance of this feature is unclear, recognition and documentation of ductal differentiation and distinguishing it from other mimics such as acantholysis within squamous nests and entrapped eccrine ducts is essential to determine its clinical significance. We also discuss the differential diagnoses of cutaneous basaloid neoplasms with ductal differentiation.
Large volcanic eruptions elucidate physiological controls of tree growth and photosynthesis
Authors: Cabon Antoine , Anderegg William R. L. 
Published: December 2022

AbstractForest productivity projections remain highly uncertain, notably because underpinning physiological controls are delicate to disentangle. Transient perturbation of global climate by large volcanic eruptions provides a unique opportunity to retrospectively isolate underlying processes. Here, we use a multi‐proxy dataset of tree‐ring records distributed over the Northern Hemisphere to investigate the effect of eruptions on tree growth and photosynthesis and evaluate CMIP6 models. Tree‐ring isotope records denoted a widespread 2–4 years increase of photosynthesis following eruptions, likely as a result of diffuse light fertilization. We found evidence that enhanced photosynthesis transiently drove ring width, but the latter further exhibited a decadal anomaly that evidenced independent growth and photosynthesis responses. CMIP6 simulations reproduced overall tree growth decline but did not capture observed photosynthesis anomaly, its decoupling from tree growth or the climate sensitivities of either processes, highlighting key disconnects that deserve further attention to improve forest productivity projections under climate change.
Autonomous driving planning and decision making based on game theory and reinforcement learning
Authors: Duan Weiping , Tang Zhongyi , Liu Wei , Zhou Hongbiao 
Published: December 2022

AbstractAutonomous driving technology is one of the important methods that avoid the hidden dangers of traffic safety. Although the existing autonomous driving technology can meet some needs of real traffic scenarios, the ability of multi‐agents to effectively generate autonomous driving strategy in complex traffic environments remains to be improved. Aiming at this problem, the automatic drive model based on game theory and reinforcement learning is proposed by combining these two technologies and applying them in multi‐agent cooperative driving, which enables multi‐agents to carry out strategic reasoning with negotiation in traffic scenarios by extending the game description language, and puts forward the constrained multi‐agents deep deterministic policies gradient algorithm. Finally, the related experiments are conducted through the autonomous driving simulation platform, and the experimental results show that the proposed model can effectively generate driving strategies for multi‐agents in complex traffic environments, which verifies the validity and feasibility of the proposed model, and provides the general research basis for multi‐agents autonomous driving.
“Is intimacy contagious?” Intimate safety with parents as a key to emerging adults' social connectedness
Authors: Yoo David , Córdova James 
Published: December 2022

AbstractObjectivesWe examined whether emerging adults' sense of intimate safety with their parents and their adult attachment style would predict emerging adults' social connectedness. Additionally, we investigated whether their social connectedness would mediate the association between emerging adults' sense of intimate safety with their parents and their rumination and anger expression.BackgroundSocial connectedness is essential to the psychological and relational health of emerging adults, particularly during the renegotiation of their relationships with their parents.MethodTwo hundred sixteen emerging adults (80% female; 61% non‐Hispanic White) completed a survey of close relationship variables.ResultsThe results suggest that emerging adults' adult attachment style mediated the relationship between emerging adults' intimate safety with their parents and social connectedness. Additionally, social connectedness mediated the relationship between emerging adults' intimate safety with their parents and their rumination and anger expression.ConclusionThis research highlights the importance of emerging adults' sense of safety to be their authentic and vulnerable selves in parent–child relationships on emerging adults' development of social connectedness and their mental and relational health.
A critical thermal transition driving spring phenology of Northern Hemisphere conifers
Authors: Huang Jian‐Guo , Zhang Yaling , Wang Minhuang , Yu Xiaohan , Deslauriers Annie , Fonti Patrick , Liang Eryuan , Mäkinen Harri , Oberhuber Walter , Rathgeber Cyrille B. K. , Tognetti Roberto , Treml Václav , Yang Bao , Zhai Lihong , Zhang Jiao‐Lin , Antonucci Serena , Bergeron Yves , Camarero Jesus Julio , Campelo Filipe , Čufar Katarina , Cuny Henri E. , De Luis Martin , Fajstavr Marek , Giovannelli Alessio , Gričar Jožica , Gruber Andreas , Gryc Vladimír , Güney Aylin , Jyske Tuula , Kašpar Jakub , King Gregory , Krause Cornelia , Lemay Audrey , Liu Feng , Lombardi Fabio , del Castillo Edurne Martinez , Morin Hubert , Nabais Cristina , Nöjd Pekka , Peters Richard L. , Prislan Peter , Saracino Antonio , Shishov Vladimir V. , Swidrak Irene , Vavrčík Hanuš , Vieira Joana , Zeng Qiao , Liu Yu , Rossi Sergio 
Published: December 2022

AbstractDespite growing interest in predicting plant phenological shifts, advanced spring phenology by global climate change remains debated. Evidence documenting either small or large advancement of spring phenology to rising temperature over the spatio‐temporal scales implies a potential existence of a thermal threshold in the responses of forests to global warming. We collected a unique data set of xylem cell‐wall‐thickening onset dates in 20 coniferous species covering a broad mean annual temperature (MAT) gradient (−3.05 to 22.9°C) across the Northern Hemisphere (latitudes 23°–66° N). Along the MAT gradient, we identified a threshold temperature (using segmented regression) of 4.9 ± 1.1°C, above which the response of xylem phenology to rising temperatures significantly decline. This threshold separates the Northern Hemisphere conifers into cold and warm thermal niches, with MAT and spring forcing being the primary drivers for the onset dates (estimated by linear and Bayesian mixed‐effect models), respectively. The identified thermal threshold should be integrated into the Earth‐System‐Models for a better understanding of spring phenology in response to global warming and an improved prediction of global climate‐carbon feedbacks.