bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Fall and Rise of Cosmic Dust in SN 2018evt
Authors: Wang Lingzhi , Hu Maokai , Wang Lifan , Yang Yi , Yang Jiawen , Gomez Haley , Chen Sijie , Hu Lei , Chen Ting-Wan , Mo Jun , Wang Xiaofeng , Baade Dietrich , Maund Justyn , Hoeflich Peter , Wheeler J. Craig , Pignata Giuliano , Burke Jamison , Hiramatsu Daichi , Howell D. Andrew , McCully Curtis , Pellegrino Craig , Galbany Lluís , Hsiao Eric , Sand David , Zhang Jujia , Uddin Syed , Anderson Joseph , Ashall chris , Cheng Cheng , Gromadzki Mariusz , Inserra Cosimo , Lin Han , Morrell Nidia , Morales-Garoffolo Antonia , M\”uller-Bravo Tom\’as , Nicholl Matt , Gonzalez Este Padilla , Phillips Mark , Pineda-Garcia J. , Sai Hanna , Smith Mat , Shahbandeh Melissa , Srivas Shubham , Stritzinger Maximilian , Yang Sheng , Young David , Yu Lixin , Zhang Xinhan 
Published: December 2022

Abstract
The amount of cosmic dust contributed by stellar sources in galaxies at all cosmic epochs remains a controversial topic, particularly whether or not supernovae (SNe) have an important role to play given the dust-hostile environments provided by SNe. To date, freshly-formed dust has been observed in a handful of core collapse (CC) SNe, both in the ejecta in-situ and in the interactions between the ejecta and circumstellar medium (CSM). As yet, there exists no clear observational evidence for dust formation in Type Ia SNe despite predictions of $3×10^{-4}$- $0.2$ Msun of dust forming per Ia. Here we report evidence of dust formation in the ejecta-CSM interaction in the Type Ia (SNIa) SN2018evt just three years after the explosion, characterized by a staggering rise in the mid-infrared (MIR) flux accompanied by an accelerated decline in the optical. This hypothesis is strengthened by the concurrent evolution of the profiles of the Hα emission lines. A preexisting hydrogen-rich torus which itself may be dusty before the SN explosion, provides a natural explanation of the observed data. SN 2018evt is the first SNIa with clear evidence of both dust destruction and formation in its ejecta and surroundings. The amount of the newly formed dust follows a steep power law rise of index 4 with time after the explosion. This steep rise indicates that the newly formed dust is formed in the SN ejecta, which is compressed by the shock interaction with the CSM.
High sensitivity of photodetection via fermion to boson condensation
Authors: Huang Zhiming , Wu Tuntan , Qiu Qinxi , Li Yongzhen , Zhou Qiangguo , Ma Wanli , Li Jingbo , Jiang Lin , Zhou Wei 
Published: December 2022

Abstract
Boson exhibits neutral charge property and negligible contribution to electrical transport. Therefore, it is very significant to enhance the electrical performance of optoelectronics. However, it is difficult to utilize the bosonic behaviors in photodetection due to its fermionic quantum statistical distribution, which is quite different to that of bosons. Herein, we realize a high sensitivity of photodetection via fermion to boson condensation in layered titanium selenide (TiSe2) under rapid and slow cooling procedures. The bosonic condensation, revealed by creative combination of the temperature-dependent electromagnetic induced well (EIW) effect and the resistance of TiSe2, obviously not only decreases the fermionic carrier concentration but also improves its mobility. The noise equivalent power NEP in terahertz waveband based on EIW effect is 35.45 fW·Hz-1/2, 4.53 fW·Hz-1/2 and 2.25 fW·Hz-1/2 at 0.252 THz, 0.14 THz and 0.027 THz, respectively, which shows one order of magnitude enhancement attributed to the excellent performance increase of electrical transport after bosonic condensation. Moreover, the detectivity D* in visible and infrared bands based on photoconductive effect has threefold improvement compared to no bosonic condensation. Our results provide an approach to realize low noise transport from fermion to boson condensation and pave a way for extremely sensitive photodetection in broad bands.
Are we really targeting and stimulating DLPFC by placing tES electrodes over F3/F4?
Authors: Ekhtiari Hamed , Soleimani Ghazaleh , Kuplicki Rayus , Camchong Jazmin , Opitz Alexander , Paulus Martin , Lim Kelvin 
Published: December 2022

Abstract
Background: Most transcranial electrical stimulation (tES) clinical trials place target electrodes over DLPFC based on the assumption that it would mainly stimulate the underlying brain region. Here, we assessed delivered electric fields (EF) using a symmetric and asymmetric DLPFC stimulation montage to identify additional prefrontal regions that are inadvertently targeted beyond DLPFC.
Methods: Head models were generated from the human connectome project database's T1+T2-weighted MRIs of 80 healthy adults. Two common DLPFC montages (symmetric: F4/F3, asymmetric: F4/Fp1 with 5×7cm electrodes, 2mA intensity) were simulated. Averaged EF was extracted from (1) the center of the target electrode (F4), and (2) the top 1% of voxels that showed the strongest EF in individualized EF maps. Inter-individual variabilities were quantified with standard deviation (SD) of EF peak location and value. These steps were replicated with 66 participants with methamphetamine use disorder (MUD) as an independent clinical population.
Results: In the healthy adults, EFs in the frontopolar area were significantly higher than EF “under” the target electrode in both symmetric (peak:0.41±0.06, F4:0.22±0.04) and asymmetric (peak:0.38±0.04, F4:0.2±0.04) montages (Heges’g>0.7). Group-level location for EF peaks in MNI space was located in the medial-frontopolar cortex, such that individualized EF peaks were placed in a cube with a volume of symmetric/asymmetric: 29cm3/46cm3. Similar results (with slight between-group differences) were found for MUDs that highlighted the role of the medial frontopolar cortex in both healthy and clinical populations.
Conclusions: We highlighted that in common DLPFC tES montages, DLPFC was not maximally targeted and the frontopolar area was the area that received the highest EFs. Considering inter-individual and inter-groups variability, we specifically recommended that the frontopolar role should be considered as a potential mechanism underlying the clinical efficacy of DLPFC stimulation.
Development and assessment of a nomogram for predicting the probability of achieving trifecta in patients with urolithiasis undergoing percutaneous nephrolithotomy
Authors: Luo Shuhang , Wusimanjiang Wumier , Li Pengju , Yang Rui , Huang Bin , Chen Junxing , Zeng Qinsong 
Published: December 2022

Abstract
Background: The trifecta standard is a newly proposed criteria for evaluating the outcome of percutaneous nephrolithotomy, which take into account the capability of different PCNL techniques to fully clear renal stones and patient comfort and quality of life. Our purpose was to develop a novel nomogram to preoperatively predict the outcomes of percutaneous nephrolithotomy (PCNL) based on the new concept, trifecta.
Methods: A total of 201 patients who received PCNL between June 2021 and June 2022 were included. The least absolute shrinkage and section operator (LASSO) method was used to select the optimal predictive features, and multivariable logistic regression analysis was utilized to construct a predictive model by incorporating the factors selected with the LASSO regression model. Discrimination, calibration, and clinical usefulness of the predictive model were assessed using the C-index, calibration plot, and decision curve analysis. Internal validation was assessed using bootstrapping validation.
Result: Factors included in the nomogram were urine culture result, aciduria, maximum cross-sectional area (CSA) of stone, stone amount, stone density, number of affected calices, lower calyx affected, and hydronephrosis degree. The model exhibited promising discrimination with a C-index of 0.781, and internal validation exhibited a C-index value of 0.747. Decision curve analysis showed the nomogram was clinically useful when intervention was decided at the achieving trifecta possibility threshold of 14%.
Conclusion: The nomogram developed exhibits a satisfactory predictive value for predicting the probability of achieving trifecta in patients undergoing PCNL. It may also assist in preoperative management to increase the probability of achieving trifecta.
Trial registration: ChiCTR2200055385, June 2021, retrospectively registered.
Diabetes Mellitus Are Less Likely to Aortic Dissection: A 5-Year Single-Center Analysis on independent risk factors of Aortic Dissection in Diabetes Mellitus Patients
Authors: Yang Xi , Chen Ling , Wu Jiang-bin , Chen Ke-yuan , Li Yu-mei , Chen Liang-wan 
Published: December 2022

Abstract
Background
Diabetes mellitus (DM) is a severe risk factor in most cardiovascular diseases, but is negatively associated with the incidence of acute aortic dissection (AAD). The purpose of this study was to explore the independent risk factors for DM patients who are still with AAD and to establish a nomogram model to predict the risk of AAD in DM patients.
Methods
Clinical data on 364 DM patients who got surgical indications was collected from January 2016 to December 2021. These patients were divided into negative and positive cohorts according to the diagnosis of AAD. The logistic proportional hazards model was used to find out the risk factors related to DM patients with AAD. A nomogram was generated based on the contribution weights of the independent risk factors. AD mice model was constructed to verify related risk factors in vivo.
Results
Among 364 patients, AAD occurred in 25 (6.87%) patients. Multivariable logistic regression analysis showed that, after adjusting for confounders, preoperative LDH, hypertension, BMI, and coronary heart disease (CHD) were all positively associated with the risk of AAD in DM patients. (LDH: OR:1.003, 95% Cl: 1.001–1005, p = 0.002; CHD: OR:3.591, 95% Cl: 1.142–11.289, p = 0.029; Hypertension: OR:2.854, 95% Cl: 1.087–7.494, p = 0.033; BMI: OR:1.184, 95% Cl: 1.029–1362, p = 0.018). Pharmacological inhibition of LDH in AAD mice was able to decrease the incidence of AAD from 43.75–13.33%.
Conclusion
DM patients were negatively associated with AAD, but dysregulated preoperative-LDH、BMI、hypertension and CHD are risk factors for AAD in DM patients.
Additive manufacturing of porous biominerals
Authors: Zhao Ran , Wittig Nina , de Angelis Gaia , Yuan Tianyu , Hirsch Matteo , Birkedal Henrik , Amstad Esther 
Published: December 2022

Abstract
Soft bodies of small creatures are frequently protected with hard shells whereas those of larger creatures are often supported with hard load-bearing structures. Nature usually fabricates these hard functional materials from soft organic scaffolds that are mineralized. To enable an energy-efficient locomotion of these creatures while maintaining the functionality of their protective or load-bearing components, nature minimizes the weight of these materials by making them porous. Unfortunately, methods that offer a similar degree of control over the nanometer up to the centimeter length scale structure of synthetic minerals remain elusive. Here we present a process that combines direct ink writing with emulsion templating to 3D print strong biominerals possessing pores whose diameters range from the 100s of nm up to the mm length scale at ambient temperature. After the structures have been stabilized through a second mineralization step, our samples encompass up to 80 wt% of CaCO3 and display a density and compressive strength close to those of human trabecular bones.
Exploring a new candidate gene, MSH6, related to hepatocellular carcinoma based on bioinformatics
Authors: Zhang Jiayan , Sun Mingbo , Chen Zhigang 
Published: December 2022

Abstract
Background: The expression of MSH6 is generally increased in many tumors, but its role in hepatocellular carcinoma (HCC) is unclear. The purpose of this study was to evaluate the expression of the DNA mismatch repair protein MSH6 in HCC and its impact on the prognosis of HCC patients and to clarify the mechanism by which MSH6 affects the malignant behavior of HCC.
Methods: R (4.2.1) software was used to obtain the expression level and clinical data of MSH6 mRNA in cancer tissues and adjacent tissues of patients with hepatocellular carcinoma from the Cancer Gene Atlas (TCGA) platform.The expression difference of MSH6 mRNA in normal and tumor tissues was compared, and GEO data were used to verify the above results. MSH6-related genes were analyzed by gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and GSEA. Kaplan‒Meier survival analysis, receptor operating characteristic (ROC) curves, and nomograms confirmed the predictive value of MSH6 for the clinical outcome of patients with HCC.
Results: Compared with the adjacent tissues, the expression level of MSH6 mRNA in cancer tissues from HCC patients was significantly higher. MSH6 plays a role in pathways related to digestion, the antimicrobial humoral response, and the G protein-coupled receptor signaling pathway. In HCC samples, high expression of MSH6 tended to have significant relationships with hormone activity, receptor-ligand activity, and G protein-coupled receptor binding. Kaplan‒Meier survival analysis showed that the prognosis of patients with lower MSH6 mRNA expression was significantly better than that of patients with higher MSH6 mRNA expression. The calibration plot shows that the MSH6 model has an effective performance for hepatocellular carcinoma prediction.
Conclusion: MSH6 plays an important role in the pathogenesis and progression of HCC and can be used as an indicator to evaluate and predict the prognosis and survival of hepatocellular carcinoma patients.
Relationship between impacted lower third molars and the mandibular canal: A new classification for radiographic signs in orthopantomographs
Authors: Gomes Ana Cláudia Amorim , Nogueira Daniela Guimarães de Melo , Sales Pedro Henrique da Hora , Vasconcelos Belmiro Cavalcanti do Egito , Leão Jair Carneiro , Frazão Marco Antônio Gomes , Silva Emanuel Dias de Oliveira e 
Published: December 2022

Abstract

Purpose: The aim of the study was to evaluate the increase in nerve damage after surgery of the lower third molar at different stages of rhizogenesis. The association between the existence or absence of a close relationship to the roots of the third molar and the mandibular canal was considered according to sex, age and complicated tooth, as well as the enshrining of a new classification of the types of radiographic signs, which allows to relate the tooth in rhizogenesis with the mandibular canal.
Materials and Methods: The sample consisted of 150 lower third molars impacted in stages 6-10 of the Nolla Classification, with all teeth being fully impacted. In orthopantomography, the type of inclusion was evaluated according to the classification of Winter and Pell and Gregory, the degree of rhizogenesis according to Nolla (1960), the relationship between the roots and the mandibular canal and the type of radiographic signal. All cases were obtained by the same radiologist.
Results: The most frequently encountered types of radiographic sign were darkening of the roots (46%), rhizogenesis (39%) and interruption of the white lines (17%). The type of radiographic sign most frequently associated with nerve lesions was darkening of the roots.
Conclusion: The fact of extracting the impacted lower third molar, in close relationship with the mandibular canal, seems to have an increased risk of nerve damage in the last stages of risogenesis, that is, with fully formed roots. The presence of the closely related radiographic signal found in orthopantomography represents, in most cases, a true relationship, requiring the classification of the type of radiographic signal to avoid nerve damage.
Right atrial lipomatous hypertrophy: A Case Report
Authors: Frieda-Maria Kainz 
Published: December 2022

Abstract
Background
The lipomatous hypertrophy in the atrial septum (LHAS) is a separate non-neoplastic benign cardiac lesion. It presents as a non-encapsulated fat deposit in the epicardium of the septum secundum which spreads excessively in the intraartial septum except the fossa ovalis and shows the typical hourglass-shaped image, with a tendency to bulge into the right atrium which may be related with a thickening of crista terminalis. The septum thickness can reach more than 20 mm and also accumulate in the subepicardium, endocardium, mediastinum and crista terminalis. This is most frequently seen in obese, elderly female patients. Complications of LHAS are severe cardiac arrhythmias (sick sinus syndrome, arrhythmias, changes in P waveform morphology in electrocardiogram (ECG)), vena cava superior syndrome, heart failure, pericardial effusion and sudden cardiac death requiring an urgent cardiovascular surgery.
Case presentation
We report about a 78-year-old female patient with a two-vessel coronary artery disease (CAD) with 50% of the circumflex artery (CX) and 60% stenosis of the right coronary artery (RCA) and a tumor mass in the right atrium with unclear dignity. Also, she had atrial fibrillation and massive supra ventricular extrasysoles.
She received a reduction of the tumor mass with an atrial xenopericardial patch plastic, an enlargement of the superior vena cava and an aorta coronary bypass (ACBP) to the RCA.
Conclusion
The LHAS is a rare and benign mass, possibly causing atrial arrhythmias depending of the location. It can also be quite challenging to access the heart cavities and can cause many complications, like mitral or tricuspid regurgitation, stenosis or septal defects.
Chemotherapy potentiates CD8+ T cell cytotoxicity through stimulating cancer cell-autonomous type I IFN induction via oxidized mtDNA sensing
Authors: Gui Jun , Qiao Wen , Hu Cegui , Ma Jiayi , Dong Xinrui , Dalangood Sumiya , Li Hanjun , Yuan Chenwei , Lu Binbin , Gao Wei-Qiang , Wen Zhenke , Yin Wenjin 
Published: December 2022

Abstract
In addition to the direct tumor cell cytotoxicity, chemotherapy also plays roles in modulating immune response. However, the underlying mechanism is not fully understood. Here we found that chemotherapy enhanced tumor cell antigen presentation to facilitate CD8+ T cell cytotoxic function. Cancer cell-autonomous type I IFN induction stimulated by chemotherapy was critical for CD8+ T cell cytotoxicity. Mechanistically, chemotherapy impaired mitochondrial function and anti-oxidant capacity, which increased reactive oxygen species (ROS) production. ROS triggered oxidized mtDNA accumulation in the cytosol of tumor cells and subsequently activated cGAS-STING signaling to drive type I IFN induction. cGAS-STING-IFN axis increased PD-L1 expression and predicted effective clinical responses to chemoimmunotherapy. Our findings highlight that a suitable dose of chemotherapy activates CD8+ T cell immunity instead of directly inducing intense tumor cell toxicity, which may alleviate the side effects of chemotherapy and potentiate the sensitivity to immune checkpoint inhibitors (ICIs). Screening chemotherapeutic drugs or developing new drugs which can stimulate type I IFN production in the tumor cells efficiently promote anti-tumor immunity and will be beneficial for chemoimmunotherapy. Conversely, antioxidants like N-acetylcysteine which impede type I IFN induction, attenuate the therapeutic efficacy and will be unfavorable for patients that are receiving chemoimmunotherapy.
UCHL1 inhibited by reactive astrocytes facilitates aggregates clearance to promote neural stem cell activation
Authors: Ding Lu , Chu Weiwei , Xia Yu , Shi Ming , Li Tian , Luo Liang , Zhou Feng-Quan , Deng David 
Published: December 2022

Abstract
Activation of the endogenous neural stem cells (NSCs) is critically important for the adult neurogenesis. However, NSC activation is extremely limited in the non-neurogenic spinal cord after spinal cord injury (SCI). Recent evidence suggests that accumulation of protein aggregates impedes quiescent NSC activation. Here, we found that ubiquitin c-terminal hydrolase l-1 (UCHL1), an important deubiquitinating enzyme, functioned to facilitate NSC activation by clearing protein aggregations through ubiquitin-proteasome pathway. Based on protein microarray analysis of SCI cerebrospinal fluid, it is further revealed that C3+ neurotoxic reactive astrocytes negatively regulated UCHL1 and the subsequent protein aggregations clearance to restrict NSC activation via C3/C3aR signaling. Upregulation of UCHL1 and blockade of reactive astrocytes or C3/C3aR pathway efficiently enhanced Nestin+ NSC activation after SCI. Together, this study elucidated a mechanism regulating NSC activation in the adult spinal cord involving the UCHL1-proteasome approach, providing a promising strategy and novel molecular targets for SCI repair.
Rating Wildfire Danger by Big Weather Data and Machine Learning: A Case Study in Eastern China
Authors: Gao Demin , He Cheng , Ma Yunfei , Chen Jie , Huang Xinyan 
Published: December 2022

Abstract
Wildfire, as a natural phenomenon, shapes global ecosystems and threatens human communities. The meteorological conditions of the forest environment is one of the critical factors, which exists obvious effect on the risk of wildfire for a given landscape and fuel type. It is high challenge to predict wildland fire risks owing to the huge amount of meteorological paramenters with volume,variety,value and velocity. Driven by the emerging Artificial Intelligence and Big Data analytics, this work proposes a machine learning model (Fuzzy C-Means algorithm) to assess the probability of wildland fire. By training the historical weather and fire data in Eastern China (Jiangsu Province), the complex relationships between the weather parameter and the rating of wildland fire danger are quantified. The Fire Weather Index system are applied to evaluate the accuracy of predictions and compare them with the standards in the literature. This system further reveals that the spring season is the peak period for wildland fires in Eastern China. Such a prediction is also in accordance with the practice of wildfire occurrence that, in practice, can provide early warning to local residences and forest services.
How Much Do Medical Students Know About Cancer Risk Factors?
Authors: Keten Hamit Sirri , Dogan Guler Gizem , Akbayram Hatice Tuba , Isik Oguz 
Published: December 2022

Abstract
Purpose
In this study, we aimed to determine the knowledge level of medical students regarding cancer risk factors (CRF).
Methods
This study was carried out in Gaziantep University (Gaziantep, Turkey) between February 10 and March 04 of 2022. A total of 532 students at Gaziantep University Faculty of Medicine took part in the study.
Results
Of the students, 270 (50.8%) were female, 262 (49.2%) were male, and the mean age was 22.63 ± 2.66 years. The mean CRF knowledge score of the participants was 23.17 ± 7.20. Knowledge scores of women and men were similar (23.06 ± 7.35 vs 23.32 ± 7.08, respectively p = 0.674).
Conclusions
The most commonly known CRF was smoking and alcohol. It was determined that medical students had serious lack of knowledge about CRF.