bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repensar el Patrimonio Mundial para repercutir en la Humanidad
Authors: Arribas Alonso Silvia 
Published: July 2022

El Patrimonio Mundial en el 50 aniversario de la Convención requiere un examen de conciencia. Por una parte, aquellos bienes inscritos en la Lista del Patrimonio Mundial son más reconocidos y apreciados, más estudiados y reciben mayor atención y recursos que aquellos que no tienen tal consideración. Sin embargo, no son vistos como referentes, son vistos como bienes superiores y no representativos.
La mercantilización del sistema, que penetra en todas las cotas, supone para el Patrimonio Mundial un hándicap importante a superar al verse en la necesidad de depender del turismo y de sus consecuencias más feroces. La espectacularización y la especulación son también graves problemas por solucionar. Es necesario redefinir el Patrimonio Mundial, sus motivaciones, sus objetivos y sus necesidades para que ejerza como eje dinamizador y colabore en el desarrollo sostenible de la humanidad y del planeta tanto en el presente como en el futuro.
KEANEKARAGAMAN HAYATI FLORA DAN FAUNA DI KAWASAN TAMAN NASIONAL BUKIT BARISAN SELATAN (TNBBS) RESORT MERPAS BINTUHAN KABUPATEN KAUR
Authors: Malik Azis Abdul , Prayudha S Joko , Anggreany Ririn , Sari May Wulan , Walid Ahmad 
Published: July 2022

ABSTRAK Taman nasional merupakan salah satu kawasan konservasi terbaik untuk menyaksikan keindahan fenomena alam terutama untuk flora dan fauna endemik, langka dan dilindungi (Kementerian Kehutanan, 2003) sehingga keberadaan taman nasional memiliki arti yang sangat strategis dan penting dalam keanekaragaman hayati tari peles. Taman Nasional Bukit Barisan Selatan memiliki keanekaragaman hayati yang sangat kaya. Oleh UNESCO, taman nasional ini ditetapkan sebagai Klaster Situs Warisan. Pegunungan Hutan Hujan Tropis Sumatera (Pegunungan Hutan Hujan Tropis Warisan Situs Klaster Sumatera) bersama dengan Taman Nasional Kerinci Seblat dan Taman Nasional Gunung Leuser. Penelitian ini dilakukan pada bulan April hingga Mei 2020 di Taman Nasional Bukit Barisan Selatan (TNBBS), Kabupaten Bintuhan, Kabupaten Kaur, Provinsi Bengkulu. Penelitian ini bertujuan untuk memperoleh informasi tentang keanekaragaman hayati flora dan fauna Taman Nasional Bukit Barisan Selatan, khususnya di kawasan taman nasional yang memiliki keanekaragaman flora dan fauna. Hasil penelitian menunjukkan bahwa terdapat banyak jenis flora dan fauna yang memiliki keanekaragaman jenis, ditemukan jenis mamalia dan jenis burung, serta tumbuhan di kawasan TNBBS. Kata Kunci: Keanekaragaman Hayati, Flora dan Fauna, Taman Nasional Bukit Barisan Selatan. ABSTRACT The national park is one of the best conservation areas to witness the beauty of natural phenomena, especially to witness endemic, rare and protected flora and fauna (Ministry of Forestry, 2003), so that the existence of a national park has a very strategic meaning. and important in the biodiversity peles dance. Bukit Barisan Selatan National Park has a very rich biodiversity. By UNESCO, this national park was designated a Cluster Heritage Site. Sumatra Tropical Rainforest Mountains (Mountainous Tropical Rainforest Herritage of Sumatra Cluster Site) along with Kerinci Seblat National Park and Gunung Leuser National Park. This study was conducted in April to May 2020 in the Bukit Barisan Selatan National Park (TNBBS), Bintuhan District, Kaur District, Bengkulu Province. This study aims to obtain information about the biodiversity of flora and fauna of the Bukit Barisan Selatan National Park, especially in the national park area which has a variety of flora and fauna. The results showed that there were many species of flora and fauna that had a diversity of species, found species of mammals and species of birds, and plants in the TNBBS area. Keywords: Biodiversity, Flora and Fauna, Bukit Barisan Selatan National Park.
ANALISIS KEBUTUHAN PENGEMBANGAN PAKET PEMBELAJARAN BERORIENTASI PENDEKATAN KONTEKSTUAL PADA MATERI GELOMBANG TERINTEGRASI MITIGASI GEMPA BUMI UNTUK MEMBEKALKAN PENGUASAAN KONSEP SISWA
Authors: Larasati Cindy , Johan Henny , Purwanto Andik 
Published: July 2022

ABSTRAK Penelitian ini bertujuan mendeskripsikan analisis kebutuhan dari pengembangan paket pembelajaran berorientasi pendekatan kontekstual pada materi gelombang terintegrasi mitigasi gempa bumi untuk membekalkan penguasaan konsep siswa. Penelitian ini menggunakan metode Research and Development (R&D) dengan mengacu pada model 4D yang dimodifikasi menjadi 3D. Pada penelitian ini peneliti membatasi hanya sampai tahap define. Instrumen yang digunakan pada penelitian ini berupa angket analisis kebutuhan guru dan siswa di SMAN Kota Bengkulu. Berdasarkan hasil penelitian yang dilakukan dapat disimpulkan bahwa dibutuhkannya pengembangan paket pembelajaran berorientasi pendekatan kontekstual pada materi gelombang terintegrasi mitigasi gempa bumi untuk membekalkan penguasaan konsep siswa. Hal ini di dasarkan data yang diperoleh berupa 97,7% siswa menjawab “iya” yang termasuk kategori sangat setuju dan 100% guru menjawab “iya” yang termasuk kategori sangat setuju. Kata kunci : Paket pembelajaran, pendekatan kontekstual, penguasaan konsep ABSTRACT This study aims to describe the needs analysis of the development of contextual approach-oriented learning packages on integrated wave material for earthquake mitigation to provide students with mastery of concepts. This study uses the Research and Development (R&D) method with reference to the modified 4D model into 3D. In this research, the researcher limits it only to the define stage. The instrument used in this study was a questionnaire to analyze the needs of teachers and students at SMAN Bengkulu City. Based on the results of the research conducted, it can be concluded that it is necessary to develop a contextual approach-oriented learning package on integrated wave material for earthquake mitigation to provide students with mastery of concepts. This is based on the data obtained in the form of 97.7% of students answered "yes" which is included in the category of strongly agree and 100% of teachers answered "yes" which belongs to the category of strongly agree. Keywords: learning package, contextual approach, concept mastery
IMPLEMENTASI NILAI RELIGIUS SISWA KELAS XI MELALUI PENDIDIKAN AGAMA ISLAM
Authors: Nasution Hambali Alman , Usman Usman 
Published: July 2022

Penelitian ini bertujuan untuk mengetahui implementasi nilai religius siswa melalui pendidikan agama Islam di SMA Negeri 2 Kotapinang yang meliputi bentuk/proses pelaksanaan nilai relgius siswa. Penelitian ini menggunakan metode penelitian lapangan (field research) dengan pendekatan kualitatif. Hasil penelitian ini menunjukkan bahwa nilai religius siswa melalui pendidikan agama Islam di SMA Negeri 2 Kotapinang belum dapat terimplementasikan secara maksimal, praktik peribadatan belum menjadi rutinitas dan pembiasaan. Pelaksanaan pembelajaran dalam membentuk nilai relgius dengan 2 cara yaitu intrakulikuler dan ekstrakulikuler. Peran guru sebagai perencana dalam proses pembelajaran, memberikan pengawasan, hukuman, bimbingan, dan teladan sebagai panutan, dan kebijakan sekolah membuat aturan untuk berjalanya proses belajar yang efektif dan efisein. Foktor pendukung dalam pengimplementasian nilai religius siswa disekolah diantaranya: musholla, alat peraga, perpustakaan dan pengeras suara. Sedangkan faktor penghambatnya antara lain: fasilitas yang kurang memadai diantaranya musholla yang kecil, latar belakang siswa yang berbeda-beda, lingkungan yang kurang mendukung,
A NOTE ON KENMOTSU MANIFOLDS ADMITTING GENERALIZED TANAKA-WEBSTER CONNECTION
Authors: YILDIRIM Mustafa , KAYA Ramazan Çınar 
Published: July 2022

In the present paper, we investigate some tensor conditions of Kenmotsu manifolds with the generalized Tanaka-Webster connection. Using
the Q tensor whose trace is the well-known Z-tensor, we prove the conditions ξ − Q∗ flat, ϕ − Q∗ flat Kenmotsu manifold with respect to the generalized Tanaka-Webster connection.
Seed viability of feathertop Rhodes grass (Chloris virgata Sw.) reduced by silage, digestion, and sheep rumen digestion
Authors: Asaduzzaman Md , Piltz John , Koetz Eric , Hopwood Michael , Shephard Adam , Wu Hanwen 
Published: July 2022

Weed seeds can be spread by different vectors, and seed dispersal is an important mechanism for the weed to persist. Weed seeds passaging through the digestive tract of a ruminant animal is expected to result in reduced viability. Two separate experiments were conducted to determine the germinability and viability of the mature seeds of feathertop Rhodes grass (Chloris virgata Sw.) after exposure to four treatments, that is, 3 months in silage, 48 h in the rumen of steers, silage plus digestion, and passing through the digestive tract of sheep. Our results showed that three different treatments (silage, digestion, and silage plus digestion) can inhibit 90%–100% of the seed germination of feathertop Rhodes grass. Both silage and digestion reduced seed viability by 65%–90%, depending on the population. Silage followed by digestion reduced viability by 80%–97%. The sheep feeding study showed that total viable seeds from the daily recovery of feces for 12 consecutive days after ingestion was only 0.084% and 0.022% in the 2020 and 2021 experiments, respectively. In comparison with the untreated control, the seed viability of feathertop Rhodes grass was reduced by more than 99.9% after feeding through sheep, indicating that the spreading of feathertop Rhodes grass seeds via sheep feces is minimal. These results indicate that silage, digestion, silage followed by digestion, and the ingestion of mature seeds are effective non-chemical weed management options for an integrated weed management package for feathertop Rhodes grass.
Prosthesis-patient mismatch following transcatheter aortic valve replacement for degenerated transcatheter aortic valves: the TRANSIT-PPM international project
Authors: Testa Luca , Casenghi Matteo , Criscione Enrico , Van Mieghem Nicolas M. , Tchétché Didier , Asgar Anita W. , De Backer Ole , Latib Azeem , Reimers Bernhard , Stefanini Giulio , Trani Carlo , Giannini Francesco , Bartorelli Antonio , Wojakowski Wojtek , Dabrowski Maciej , Jagielak Dariusz , Banning Adrian P. , Kharbanda Rajesh , Moreno Raul , Schofer Joachim , Brinkmann Christina , van Royen Niels , Pinto Duane , Serra Antoni , Segev Amit , Giordano Arturo , Brambilla Nedy , Agnifili Mauro , Rubbio Antonio Popolo , Squillace Mattia , Oreglia Jacopo , Tanja Rudolph , McCabe James M. , Abizaid Alexander , Voskuil Michiel , Teles Rui , Zoccai Giuseppe Biondi , Sondergaard Lars , Bedogni Francesco 
Published: July 2022

BackgroundA severe prosthesis-patient mismatch (PPM) is associated with adverse outcomes following transcatheter aortic valve replacement (TAVR) for de novo aortic stenosis or a failed surgical bioprosthesis. The impact of severe PPM in patients undergoing TAV-in-TAVR is unknown.AimWe sought to investigate the incidence and 1-year outcomes of different grades of PPM in patients undergoing TAV-in-TAVR.Materials and methodsThe TRANSIT-PPM is an international registry, including cases of degenerated TAVR treated with a second TAVR. PPM severity, as well as in-hospital, 30-day, and 1-year outcomes were defined according to the Valve Academic Research Consortium-3 (VARC-3) criteria.ResultsAmong 28 centers, 155 patients were included. Severe PPM was found in 6.5% of patients, whereas moderate PPM was found in 14.2% of patients. The rate of severe PPM was higher in patients who underwent TAV-in-TAVR with a second supra-annular self-expanding (S-SE) TAVR (10%, p = 0.04). Specifically, the rate of severe PPM was significantly higher among cases of a SE TAVR implanted into a balloon-expandable (BE) device (19%, p = 0.003). At 1-year follow-up, the rate of all-cause mortality, and the rate of patients in the New York Heart Association (NYHA) class III/IV were significantly higher in the cohort of patients with severe PPM (p = 0.016 and p = 0.0001, respectively). Almost all the patients with a severe PPM after the first TAVR had a failed &lt; 23 mm BE transcatheter heart valve (THV): the treatment with an S-SE resolved the severe PPM in the majority of the cases.ConclusionAfter TAV-in-TAVR, in a fifth of the cases, a moderate or severe PPM occurred. A severe PPM is associated with an increased 1-year all-cause mortality.Clinical trial registration[https://clinicaltrials.gov], identifier [NCT04500964].
A novel signature to guide osteosarcoma prognosis and immune microenvironment: Cuproptosis-related lncRNA
Authors: Yang Mingyi , Zheng Haishi , Xu Ke , Yuan Qiling , Aihaiti Yirixaiti , Cai Yongsong , Xu Peng 
Published: July 2022

ObjectiveOsteosarcoma (OS) is a common bone malignancy with poor prognosis. We aimed to investigate the relationship between cuproptosis-related lncRNAs (CRLncs) and the survival outcomes of patients with OS.MethodsTranscriptome and clinical data of 86 patients with OS were downloaded from The Cancer Genome Atlas (TCGA). The GSE16088 dataset was downloaded from the Gene Expression Omnibus (GEO) database. The 10 cuproptosis-related genes (CRGs) were obtained from a recently published article on cuproptosis in Science. Combined analysis of OS transcriptome data and the GSE16088 dataset identified differentially expressed CRGs related to OS. Next, pathway enrichment analysis was performed. Co-expression analysis obtained CRLncs related to OS. Univariate COX regression analysis and least absolute shrinkage and selection operator (LASSO) regression analysis were used to construct the risk prognostic model of CRLncs. The samples were divided evenly into training and test groups to verify the accuracy of the model. Risk curve, survival, receiver operating characteristic (ROC) curve, and independent prognostic analyses were performed. Next, principal component analysis (PCA) and t-distributed stochastic neighbor embedding (t-SNE) analysis were performed. Single-sample gene set enrichment analysis (ssGSEA) was used to explore the correlation between the risk prognostic models and OS immune microenvironment. Drug sensitivity analysis identified drugs with potential efficacy in OS. Real-time quantitative PCR, Western blotting, and immunohistochemistry analyses verified the expression of CRGs in OS. Real-time quantitative PCR was used to verify the expression of CRLncs in OS.ResultsSix CRLncs that can guide OS prognosis and immune microenvironment were obtained, including three high-risk CRLncs (AL645608.6, AL591767.1, and UNC5B-AS1) and three low-risk CRLncs (CARD8-AS1, AC098487.1, and AC005041.3). Immune cells such as B cells, macrophages, T-helper type 2 (Th2) cells, regulatory T cells (Treg), and immune functions such as APC co-inhibition, checkpoint, and T-cell co-inhibition were significantly downregulated in high-risk groups. In addition, we obtained four drugs with potential efficacy for OS: AUY922, bortezomib, lenalidomide, and Z.LLNle.CHO. The expression of LIPT1, DLAT, and FDX1 at both mRNA and protein levels was significantly elevated in OS cell lines compared with normal osteoblast hFOB1.19. The mRNA expression level of AL591767.1 was decreased in OS, and that of AL645608.6, CARD8-AS1, AC005041.3, AC098487.1, and UNC5B-AS1 was upregulated in OS.ConclusionCRLncs that can guide OS prognosis and the immune microenvironment and drugs that may have a potential curative effect on OS obtained in this study provide a theoretical basis for OS survival research and clinical decision-making.
The cancer-associated fibroblast-related signature predicts prognosis and indicates immune microenvironment infiltration in gastric cancer
Authors: Mak Tsz Kin , Li Xing , Huang Huaping , Wu Kaiming , Huang Zhijian , He Yulong , Zhang Changhua 
Published: July 2022

BackgroundGastric cancer (GC) is one of the most common cancers, with a wide range of symptoms and outcomes. Cancer-associated fibroblasts (CAFs) are newly identified in the tumor microenvironment (TME) and associated with GC progression, prognosis, and treatment response. A novel CAF-associated prognostic model is urgently needed to improve treatment strategies.MethodsThe detailed data of GC samples were downloaded from The Cancer Genome Atlas (TCGA), GSE62254, GSE26253, and GSE84437 datasets, then obtained 18 unique CAF-related genes from the research papers. Eight hundred eight individuals with GC were classified as TCGA or GSE84437 using consensus clustering by the selected CAF-related genes. The difference between the two subtypes revealed in this study was utilized to create the “CAF-related signature score” (CAFS-score) prognostic model and validated with the Gene Expression Omnibus (GEO) database.ResultsWe identified two CAF subtypes characterized by high and low CAFS-score in this study. GC patients in the low CAFS-score group had a better OS than those in the high CAFS-score group, and the cancer-related malignant pathways were more active in the high CAFS-score group, compared to the low CAFS-score group. We found that there was more early TNM stage in the low CAFS-score subgroup, while there was more advanced TNM stage in the high CAFS-score subgroup. The expression of TMB was significantly higher in the low CAFS-score subgroup than in the high CAFS-score subgroup. A low CAFS-score was linked to increased microsatellite instability-high (MSI-H), mutation load, and immunological activation. Furthermore, the CAFS-score was linked to the cancer stem cell (CSC) index as well as chemotherapeutic treatment sensitivity. The patients in the high CAFS-score subgroup had significantly higher proportions of monocytes, M2 macrophages, and resting mast cells, while plasma cells and follicular helper T cells were more abundant in the low-risk subgroup. The CAFS-score was also highly correlated with the sensitivity of chemotherapeutic drugs. The low CAFS-score group was more likely to have an immune response and respond to immunotherapy. We developed a nomogram to improve the CAFS-clinical score’s usefulness.ConclusionThe CAFS-score may have a significant role in the TME, clinicopathological characteristics, prognosis, CSC, MSI, and drug sensitivity, according to our investigation of CAFs in GC. We also analyzed the value of the CAFS-score in immune response and immunotherapy. This work provides a foundation for improving prognosis and responding to immunotherapy in patients with GC.
Human bocavirus 1 is a genuine pathogen for acute respiratory tract infection in pediatric patients determined by nucleic acid, antigen, and serology tests
Authors: De Ri , Zhang Ke-Xiang , Wang Fang , Zhou Yu-Tong , Sun Yu , Chen Dong-Mei , Zhu Ru-Nan , Guo Qi , Liu Shuang , Qu Dong , Qian Yuan , Zhao Lin-Qing 
Published: July 2022

BackgroundHuman bocavirus 1 (HBoV1), first discovered in 2005, was positive in symptomatic and healthy children and co-detected with other respiratory viruses. It is a long journey to decisively demonstrate the unique viral pathogenic function of acute respiratory tract infection (ARTI) in pediatric patients.MethodsRespiratory specimens collected from pediatric patients with ARTI from January 2017 to December 2021 were screened by a capillary electrophoresis-based multiplex PCR (CEMP) assay, then genotyped by PCR and sequencing for HBoV1. For the antigen test, a part of HBoV1 DNA positive nasopharyngeal aspirates (NPAs) was used as an antigen, while a rabbit anti-HBoV1 DR2 specific to HBoV1 was used as an antibody in the indirect-immunofluorescence assay (IFA). Finally, the levels of IgG specific to HBoV1 in acute and convalescent sera selected retrospectively from only HBoV1 DNA-positive patients were evaluated by IFA.ResultsAmong 9,899 specimens, 681 were positive for HBoV1 DNA (6.88%, 681/9899), which included 336 positives only for HBoV1 (49.34%, 336/681) and 345 (50.66%, 345/681) positives also for other pathogens. In the antigen test, there were 37 among 47 NPAs determined as HBoV1 antigen-positive (78.72%, 37/47), including 18 (48.65%, 18/37) positives solely for HBoV1 DNA. Among 4 pediatric patients with both acute and convalescent sera, there was one positive for HBoV1 antigen (D8873) and 2 lack the antigen results (D1474 and D10792), which showed seroconversion with a ≥ 4-fold increase in IgG levels.ConclusionsThe combination results of nucleic acid, antigen, and serology tests answered that HBoV1 is a genuine pathogen for ARTI in pediatric patients.
Neuropsychiatric Symptoms of Alzheimer's Disease and Caregiver Burden
Authors: Iravani Behnam , Abdollahi Elaheh , Eslamdoust-Siahestalkhi Fatemeh , Soleimani Robabeh 
Published: July 2022

Introduction/ObjectivesIn addition to cognitive decline, one of the most important problems for caregivers of patients with Alzheimer's is neuropsychiatric symptoms (NPS). This study aimed to evaluate the NPS in patients with Alzheimer's disease (AD) and investigate its relationship with caregiver burden (CB).MethodsIn a cross-sectional study of 85 patients with AD referred to Shafa Hospital in Rasht and their caregivers in 2020, information was collected using a demographic questionnaire, Neuropsychiatric Inventory Questionnaire (NPI-Q), and the Caregiver Burden Inventory (CBI). Data were analyzed by Spearman correlation, t-test, and linear regression, with SPSS version 22.ResultsThe mean age of the patients and their caregivers were 74.95 ± 8.87 years and 43.98 ± 11.38 years, respectively. The mean total score of NPS in patients with AD was 44.25 (0–144) and the mean CB score was 36.27 (0–96), which was a moderate level. According to the results, 91% of patients had apathy, while happiness/euphoria was reported as the most uncommon symptom. In addition, there was a significant relationship between the score of NPS and CB (r = 0.542, P &lt; 0.0001), as well as all its sub-components, time-dependence burden with more correlation (r = 0.509, P &lt; 0.0001), and social burden with less correlation (r = 0.352, P &lt; 0.001). NPS, hallucination, aberrant motor behavior (AMB), delusion, and depression were most correlated with CB. Also, the mean score of CB was significantly higher in women than in men (P = 0.045). Living in a rural area had a significant relationship with NPS score (P = 0.026). Also, linear regression showed that with increasing 1 year of patients' age, the mean score of patient's NPS decreased by 0.374 (P = 0.048).ConclusionNeuropsychiatric symptoms, especially hallucination, aberrant motor behavior (AMB), delusion, and depression were associated with caregiver burden. Apathy was the most common symptom in patients with AD.