bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge Retention and Changes in Licensed Chainsaw Workers’ risk awareness
Authors: Häggström Carola , Edlund Björn 
Published: April 2022

AbstractWork with chainsaws is hazardous and felling trees is the activity with the highest risks for injuries and fatalities. While industrial forestry is increasingly mechanized, manual felling is still the main work method for private, small-scale forest owners. During this work, the workers’ safety heavily depends on their skill and safe practice, so training is presumably important for preventing injuries and reducing fatalities. Unfortunately, private forest owners have been difficult to reach with this kind of safety intervention. Moreover, target chainsaw users are not likely to repeat the training very frequently. Hence, the training must both be effective and be so for many years to come. This paper addresses the knowledge retention and self-reported changes in behaviour of 682 chainsaw users who passed the exam for the Swedish chainsaw licence 1, 3, 5, 7 or 9 years previously. Acquisition of the licence resulted in a strong increase in 98% of the participants’ risk awareness and safe work practices. Less than half (45%) of the participants passed a re-test equivalent to the theoretical examination for the chainsaw licence. Private forest owners performed somewhat better than employees did. The main indicator of retained knowledge of safe chainsaw handling was frequency of practice the previous year. After one year, the test results did not deteriorate with additional time. Based on those results, the best practice is to ensure regular usage of the chainsaw and refresher training when the chainsaw has not been used for a year.
Triplet Therapy in Melanoma — Combined BRAF/MEK Inhibitors and Anti-PD-(L)1 Antibodies
Authors: Dixon-Douglas Julia R. , Patel Riyaben P. , Somasundram Pretashini M. , McArthur Grant A. 
Published: April 2022

Abstract

Purpose of Review
We provide an updated review of clinical trials evaluating the combination of BRAF/MEK inhibitors with anti-PD-(L)1 therapy (triplet therapy) for patients with advanced BRAF-mutant melanoma, accompanied by a summary of the biological evidence supporting this combination.

Recent Findings
Resistance to BRAF/MEK inhibition and comparatively low response rates to immune checkpoint inhibitors remain clinical challenges in the treatment of melanoma. Preclinical data demonstrates that targeted therapy is immune-modulatory and synergises with immune checkpoint inhibition. Several randomised controlled trials have evaluated the combination of targeted therapy with immune checkpoint inhibition.

Summary
Triplet therapy has shown improvements in progression-free survival and durability of response compared to BRAF/MEK inhibition alone; however, questions remain regarding the best clinical scenario for implementation of this regimen in the era of front-line immunotherapy.
Antifungal Activity of Endophytic Aspergillus terreus Extract Against Some Fungi Causing Mucormycosis: Ultrastructural Study
Authors: Hashem Amr H. , Shehabeldine Amr M. , Abdelaziz Amer M. , Amin Basma H. , Sharaf Mohamed H. 
Published: April 2022

AbstractEndophytes fungi are applied as favorable safe antifungal agents as well as natural bioactive compounds reservoir. In the current study, the inhibitory effect of endophytic fungus was explained by direct antifungal activity against fungi causing mucormycosis, ultrastructural, and determination of active compounds in fungal extract. EndophyticAspergillus terreuswas isolated from healthyMoringa oleiferaleaves and identified morphologically and genetically, and was recorded in gene bank with accession number MW444551.1. Phytochemical analysis and gas chromatography-mass spectroscopy (GC–MS) of ethyl acetate crude extract (EACE) ofA. terreuswere performed. GC–MS results of EACE ofA. terreusrevealed that fungal extract contains 16 major bioactive compounds with extensive pharmaceutical activities. Furthermore, EACE ofA. terreusrevealed a promising antifungal activity against fungi causing mucormycosis asRhizopus oryzae,Mucor racemosus,and Syncephalastrum racemosum, where inhibition zones of EACE (10 mg/ml) were 20, 37, and 18 mm, respectively. Minimum inhibitory concentration (MIC) of EACE was 0.3125 towardM. racemosus, while 1.25 and 2.5 mg/ml againstR. oryzae and S. racemosum, respectively. In the same context, treatedR. oryzae,M. racemosus,and S. racemosumwith EACE ofA. terreusrevealed elevation of membrane lipid peroxidation which approves membrane leakage. Furthermore, ultrastructure changes were observed which established alteration in both sporangium and hyphal structures; cell membrane and cytoplasm leakage. In conclusion, endophyticA. terreushas an outstanding antifungal activity against fungi causing mucormycosis.
Research on fish identification in tropical waters under unconstrained environment based on transfer learning
Authors: Zhang Shan , Liu Weifang , Zhu Yupeng , Han Wei , Huang Yi , Li Jianqiang 
Published: April 2022

AbstractSeafloor unconstrained environment video is shot in uncontrolled open sea area. There are multiple backgrounds, complex illumination and weather changes, and rapid growth of algae and attached lenses, which affect the stability of video shooting quality, resulting in difficulty in image recognition. At present, there is still no algorithm that is superior to other methods generally, and it is necessary to build a model combined with specific scenes and applications. In this paper, a fish identification method in tropical waters based on transfer learning under unconstrained environment is proposed. Firstly, the image is pre-processed by affine transformation to realize data enhancement. Furthermore, RestNet50 deep convolutional neural network is constructed based on transfer learning to compare the effect of fish recognition before and after transfer learning. The results show that, the accuracy and loss indicators are better than those of non-transfer learning when the trained model of imagenet is introduced as the initial weight of the network. When the model is trained to 150 epochs, the indicators begin to converge, which can better complete the fish identification task in tropical waters under unconstrained environment.
Successful storage of Trichomonas gallinae on Whatman FTA cards following culture
Authors: Thomas Rebecca C. , Dunn Jenny C. , Orsman Chris J. , Morris Antony J. , Hipperson Helen , Grice Philip V. , Hamer Keith C. , Goodman Simon J. 
Published: April 2022

AbstractLogistical constraints concerning parasite sample storage can hinder progress with the discovery of genetic variation on a global scale. New storage methods are being developed to address this, but require testing in order to understand how widely applicable these methods are. Whatman FTA cards have been tested previously under laboratory conditions for storing low-concentration Trichomonas gallinae isolates with the conclusion that they are not suitable, but have not been tested under field conditions. Here, we conducted a field-test, comparing FTA cards with storage in ethanol for T. gallinae samples collected and cultured from wild Columbiformes in Africa using standard field methods, before transportation to the UK. After 6 months storage, both methods resulted in an overall prevalence of 100% following PCR amplification (n = 59), suggesting that FTA cards are suitable for estimation of T. gallinae prevalence. However, samples stored in ethanol produced more, and longer, sequences than those stored on FTA cards. These data suggest storage in ethanol is preferable for the acquisition of high quality genetic strain data, but that FTA cards can be used successfully to ascertain infection prevalence and identify parasite strains under field conditions.
An Ambiguous Role for Fever in Worsening Outcome After Intracerebral Hemorrhage
Authors: Liddle Lane J. , Dirks Christine A. , Almekhlafi Mohammed , Colbourne Frederick 
Published: April 2022

Abstract
Intracerebral hemorrhage (ICH) accounts for 10–15% of all strokes and leaves most survivors with impairments. Fever, a rise in the thermoregulatory set point, complicates ICH. This review summarizes ICH fever studies and employs meta-analytic techniques to explore the relationship between fever and ICH. We discuss methodological considerations for future studies and provide an overview of mechanisms by which fever, and its treatment, may impact ICH. We searched the PubMed database using the following terms: ((fever OR hyperthermia) AND (intracerebral hemorrhage OR intraparenchymal hemorrhage OR intracerebral haemorrhage OR intraparenchymal haemorrhage)). Our search returned 727 studies, of which 21 were included in our final analysis, consisting of 19 clinical, and two preclinical, studies. We conducted a meta-analysis on the clinical data to quantify how fever is related to mortality, functional outcomes, and intraventricular hemorrhage. Analysis of clinical studies suggested that fever causes an increased risk of mortality but does not appear to be associated with poor outcomes among survivors, making it difficult to ascertain the extent of harm caused by post-ICH fever or the benefits of its treatment. Perhaps these inconsistencies stem from variable fever definitions, and temperature measurement and fever treatment protocols. Additionally, the lack of mechanistic data in clinical studies coupled with preclinical studies showing no harmful effects of moderate bouts of hyperthermia raise concerns about the direct contribution of hyperthermia and fever in post ICH outcome. Overall, the significance of temperature increases after ICH is unclear, making this an important area for future research.
Efficient use of data for LSTM mortality forecasting
Authors: Lindholm M. , Palmborg L. 
Published: April 2022

AbstractWe consider a simple long short-term memory (LSTM) neural network extension of the Poisson Lee-Carter model, with a particular focus on different procedures for how to use training data efficiently, combined with ensembling to stabilise the predictive performance. We compare the standard approach of withholding the last fraction of observations for validation, with two other approaches: sampling a fraction of observations randomly in time; and splitting the population into two parts by sampling individual life histories. We provide empirical and theoretical support for using these alternative approaches. Furthermore, to improve the stability of long-term predictions, we consider boosted versions of the Poisson Lee-Carter LSTM. In the numerical illustrations it is seen that even in situations where mortality rates are essentially log-linear as a function of calendar time, the boosted model does not perform significantly worse than a simple random walk with drift, and when non-linearities are present the predictive performance is improved. Moreover, boosting allows us to obtain reasonable model calibrations based on as few data points as 20 years.
Indole alkaloids of Alstonia scholaris (L.) R. Br. alleviated nonalcoholic fatty liver disease in mice fed with high-fat diet
Authors: Sun Shui-Fen , Zhong Hui-Jie , Zhao Yun-Li , Ma Xiu-Ying , Luo Jin-Bo , Zhu Ling , Zhang Yu-Ting , Wang Wen-Xue , Luo Xiao-Dong , Geng Jia-Wei 
Published: April 2022

AbstractAlstonia scholaris (L.) R. Br (Apocynaceae) is a well-documented medicinal plant for treating respiratory diseases, liver diseases and diabetes traditionally. The current study aimed to investigate the effects of TA on non-alcoholic fatty liver disease (NAFLD). A NAFLD model was established using mice fed a high-fat diet (HFD) and administered with TA (7.5, 15 and 30 mg/kg) orally for 6 weeks. The biochemical parameters, expressions of lipid metabolism-related genes or proteins were analyzed. Furthermore, histopathological examinations were evaluated with Hematoxylin–Eosin and MASSON staining. TA treatment significantly decreased the bodyweight of HFD mice. The concentrations of low-density lipoprotein (LDL), triglyceride (TG), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were also decreased significantly in TA-treated mice group, accompanied by an increase in high-density lipoprotein (HDL). Furthermore, TA alleviated hepatic steatosis injury and lipid droplet accumulation of liver tissues. The liver mRNA levels involved in hepatic lipid synthesis such as sterol regulatory element-binding protein 1C (SREBP-1C), regulators of liver X receptor α (LXRα), peroxisome proliferator activated receptor (PPAR)γ, acetyl-CoA carboxylase (ACC1) and stearyl coenzyme A dehydrogenase-1 (SCD1), were markedly decreased, while the expressions involved in the regulation of fatty acid oxidation, PPARα, carnitine palmitoyl transterase 1 (CPT1A), and acyl coenzyme A oxidase 1 (ACOX1) were increased in TA-treated mice. TA might attenuate NAFLD by regulating hepatic lipogenesis and fatty acid oxidation.
Insights on Chemical and Natech Risk Management in Japan and South Korea: A Review of Current Practices
Authors: Park Hyejeong , Cruz Ana Maria 
Published: April 2022

AbstractA growing number of natural hazard-triggered technological accidents (Natech) has been reported by several researchers, and this trend is expected to continue due to climate change. As a result, some governments have initiated direct efforts to manage Natech risks, particularly in the United States and Europe. However, two surveys conducted by the Organisation for Economic Co-operation and Development (OECD) in 2009 and 2017 found that there was a lack of proper risk management and risk governance for Natech among OECD member states, including Japan and South Korea. This study aimed to identify relevant regulations and practical considerations for chemical and Natech risk management from government perspectives in Japan and South Korea. The article provides a review of the current state of risk management, emergency response, and risk communication on chemical and Natech risk management in the two countries, and concludes with a discussion of some of the issues that require improvement of the current chemical risk management. Current practices for chemical risk management in Japan and South Korea point to the possibility of improvements in dealing with the Natech risks. These practical lessons will be valuable for improving the capacity for dealing with challenges in chemical and Natech risk management.
Synthesis and property characterization of ternary laminar Zr2SB ceramic
Authors: Zhang Qiqiang , Fu Shuai , Wan Detian , Bao Yiwang , Feng Qingguo , Grasso Salvatore , Hu Chunfeng 
Published: April 2022

AbstractIn this paper, Zr2SB ceramic with purity of 82.95 wt% (containing 8.96 wt% ZrB2 and 8.09 wt% zirconium) and high relative density (99.03%) was successfully synthesized from ZrH2, sublimated sulfur, and boron powders by spark plasma sintering (SPS) at 1300 °C. The reaction process, microstructure, and physical and mechanical properties of Zr2SB ceramic were systematically studied. The results show that the optimum molar ratio to synthesize Zr2SB is n(ZrH2):n(S):n(B) = 1.4:1.6:0.7. The average grain size of Zr2SB is 12.46 µm in length and 5.12 µm in width, and the mean grain sizes of ZrB2 and zirconium impurities are about 300 nm. In terms of physical properties, the measured thermal expansion coefficient (TEC) is 7.64×10−6 K−1 from room temperature to 1200 °C, and the thermal capacity and thermal conductivity at room temperature are 0.39 J·g−1·K−1 and 12.01 W·m−1·K−1, respectively. The room temperature electrical conductivity of Zr2SB ceramic is measured to be 1.74×106 Ω−1·m−1. In terms of mechanical properties, Vickers hardness is 9.86±0.63 GPa under 200 N load, and the measured flexural strength, fracture toughness, and compressive strength are 269±12.7 MPa, 3.94±0.63 MPa·m1/2, and 2166.74±291.34 MPa, respectively.
Adsorption of 4-Nitrophenol onto Iron Oxide Bentonite Nanocomposite: Process Optimization, Kinetics, Isotherms and Mechanism
Authors: Ewis Dina , Ba-Abbad Muneer M. , Benamor Abdelbaki , Mahmud Nafis , Nasser Mustafa , El-Naas Muftah , Mohammad Abdul Wahab 
Published: April 2022

AbstractDespite its importance in chemical industry, 4-Nitrophenol (4-NP) is a persistent organic pollutant that has serious effects on the ecosystem. In the present study, Box–Behnken design in response surface methodology was used to optimize the adsorption process parameters for the maximum 4-NP removal at 30 ℃ using Fe3O4/Bt NC. The regression model results suggested that the optimum adsorbent dosage, initial concentration, pH and contact time were 0.3182 g, 85 mg/L, 11 and 137.2 min, respectively. The regression model showed an optimum removal of 100%, while 99.5% removal was obtained from batch experiments at the optimum conditions suggested by the regression model, which confirm the model validity. The adsorption data best fitted to Freundlich isotherm model and Pseudo second-order kinetic model suggesting the existence of physical and chemical interaction between the fabricated composite and 4-NP. FTIR analysis suggested that the adsorption mechanism included an electrostatic attraction and the formation of new chemical bonds. Obtained results suggest that Fe3O4/Bt NC can be an effective adsorbent for complete 4-NP removal at the indicated optimum conditions.
Graphical Abstract
An Entangled Pedagogy: Looking Beyond the Pedagogy—Technology Dichotomy
Authors: Fawns Tim 
Published: April 2022

Abstract‘Pedagogy first’ has become a mantra for educators, supported by the metaphor of the ‘pedagogical horse’ driving the ‘technological cart’. Yet putting technology firstorlast separates it from pedagogy, making us susceptible to technological or pedagogical determinism (i.e. where technology is seen either as the driving force of change or as a set of neutral tools). In this paper, I present a model of entangled pedagogy that encapsulates the mutual shaping of technology, teaching methods, purposes, values and context. Entangled pedagogy is collective, and agency is negotiated between teachers, students and other stakeholders. Outcomes are contingent on complex relations and cannot be determined in advance. I then outline an aspirational view of how teachers, students and others can collaborate whilst embracing uncertainty, imperfection, openness and honesty, and developing pedagogical knowledge that is collective, responsive and ethical. Finally, I discuss implications for evaluation and research, arguing that we must look beyond isolated ideas of technologies or teaching methods, to the situated, entangled combinations of diverse elements involved in educational activity.
The NJ Alliance for Clinical and Translational Science (NJ ACTS) experience: Responding at “warp speed” to COVID-19
Authors: Thaman Pragya , Tafuto Barbara , Gélinas Céline , Gaur Sunanda , Neubauer Judith A. 
Published: April 2022

Abstract

Introduction:
The COVID-19 pandemic’s need for life-saving treatments and a "warp speed" vaccine challenged the National Institutes of Health’s Clinical and Translational Science Award (CTSA) recipients to improve their methods and processes in conducting clinical research. While CTSA recipient, New Jersey Alliance for Clinical and Translational Science (NJ ACTS), responded to this call to action with significant clinical research milestones, a comprehensive understanding of regulatory metrics during the COVID-19 pandemic is uncertain. The objective of this research is to identify, compare, and contrast metrics that illustrate the effectiveness of NJ ACTS’s research mobilization efforts during COVID-19.

Methods:
Data were collected from the Institutional Review Board (IRB), the Clinical Research Units (CRUs), and the Office of Research and Sponsored Programs (ORSP). IRB data detailed the volume and types of protocols approved and turnaround time (TAT) for approval in 2020 vs. 2019. CRU data examined study metrics of adult and pediatric clinical trials across 2018-2020. ORSP data documented awards received in 2019 and 2020

Results:
Analysis revealed a 95% increase in IRB-approved studies in 2020, with a significant decrease in TAT for COVID-19 studies. All CRUs observed a median 5.2-fold increase in the enrollment of adult and pediatric participants for COVID-19-related research. Study income was 106% and 196% greater than 2019 and 2018, respectively, with more than half funded through federal sponsors and 89% for COVID-19 trials. ORSP data revealed that 9% of awards and 26% of 2020 funding were COVID-19 studies.

Conclusion:
This study demonstrates that NJACTS effectively responded to challenges posed by the pandemic
Cancer mutation profiles predict ICIs efficacy in patients with non-small cell lung cancer
Authors: Zhu Liping , Ye Dafu , Lei Tianyu , Wu Jie , Wang Wei , Xu Bin 
Published: April 2022

Abstract
Although immune checkpoint inhibitors (ICIs) have produced remarkable responses in non-small cell lung cancer (NSCLC) patients, receivers still have a relatively low response rate. Initial response assessment by conventional imaging and evaluation criteria is often unable to identify whether patients can achieve durable clinical benefit from ICIs. Overall, there are sparse effective biomarkers identified to screen NSCLC patients responding to this therapy. A lot of studies have reported that patients with specific gene mutations may benefit from or resist to immunotherapy. However, the single gene mutation may be not effective enough to predict the benefit from immunotherapy for patients. With the advancement in sequencing technology, further studies indicate that many mutations often co-occur and suggest a drastic transformation of tumour microenvironment phenotype. Moreover, co-mutation events have been reported to synergise to activate or suppress signalling pathways of anti-tumour immune response, which also indicates a potential target for combining intervention. Thus, the different mutation profile (especially co-mutation) of patients may be an important concern for predicting or promoting the efficacy of ICIs. However, there is a lack of comprehensive knowledge of this field until now. Therefore, in this study, we reviewed and elaborated the value of cancer mutation profile in predicting the efficacy of immunotherapy and analysed the underlying mechanisms, to provide an alternative way for screening dominant groups, and thereby, optimising individualised therapy for NSCLC patients.
Boundaries and Belonging Among Settled Minorities and Refugees in Bulgaria
Authors: Carlsson Nina 
Published: April 2022

AbstractThe importance of settled minorities for facilitating refugee belonging is seldom discussed in research on refugee integration. Drawing on scholarship on belonging, boundary-making, and bordering, this study investigates how boundaries are drawn between settled minorities and refugees in Bulgaria. Based on interviews with integration workers and organizations of settled minorities in a state with the largest historically present Muslim minority in the EU, an Arabic-speaking diaspora settled decades ago, and with minimal state involvement in refugee integration, the study shows how spatial, linguistic, and religious boundaries separate settled minorities from newly arrived refugees. Arabic-speaking diasporas are nevertheless witnessed to overcome the boundaries through geographical proximity, a shared language, and shared countries of origin, whereby they have functioned as facilitators of refugee belonging and inclusion. Furthermore, Muslim institutions led by Bulgarian Turks have functioned as spaces for refugee belonging. The study finds that settled minority communities have, despite multiple boundaries and some assimilatory discourses, contributed to refugee belonging in ways that in part has compensated for the state absence. The study calls for further research investigating the role of settled minorities in inclusionary processes in society.