bluuebunny/crossref_metadata_2025_split huggingface dataset:
Still disease with persistent atypical dermatomyositis-like skin eruption: two cases associated with macrophage activation syndrome
Authors: Fernández Camporro Ángel , Rodriguez Diaz Eloy , Beteta Gorriti Valia , Gonzalvo Rodríguez Pablo , Alvarez-Cuesta César 
Published: June 2022

Abstract
The typical rash of Still disease is an asymptomatic, salmon-coloured, macular, or maculopapular eruption that appears along with the fever spikes and fades when the body temperature drops. Although not included in the diagnostic criteria, there are other frequent, persistent, pruritic and polymorphic skin manifestations of Still disease that have distinctive clinical features and specific histological findings. Among these atypical persistent pruritic eruptions (PPEs), periorbital erythema and linear flagellate papules and plaques can resemble the cutaneous manifestations of dermatomyositis (DM). The presence of these lesions in adult-onset Still disease has been associated with worse prognosis and higher mortality rates, perhaps due to the development of a secondary macrophage activation syndrome (MAS). We report two cases of Still disease with persistent atypical DM-like eruption, one in a paediatric patient (a very underreported finding) and the other in an adult. Both cases developed a secondary MAS.
The magic in the (extra)ordinary: Intensive validation to recalibrate the life‐worlds of adolescents exposed to abuse
Authors: Kolb Helen , Dovran Anders , Fernee Carina Ribe , Bøe Tore Dag 
Published: June 2022

AbstractThis qualitative case study aimed to explore environmental circumstances and interactional processes that appeared to be relevant for the dynamics of resilience in adolescents exposed to child abuse. Fieldwork at a learning and coping centre for children and their families was combined with semi‐structured interviews with adolescent participants aged 12 to 18 years. A critical realist approach was used to unpack what has been called the ‘ordinary magic’ of resilience. We found that intensively validating qualities of both the environment and relationships seemed to be driving components for resilience. Borrowing ideas from the sociometer theory, we propose that particularly the consistent intensiveness may offer a recalibration of the adolescents' immediate life‐worlds, in terms of how they perceive the people they meet and the environments they step into. In keeping with the transactional‐ecological model of resilience, we suggest that such a recalibration leads to altered social agency that becomes visible through their immediate social participation.
Microsecretory adenocarcinoma of the skin harboring recurrent SS18 fusions: A cutaneous analog to a newly described salivary gland tumor
Authors: Bishop Justin A. , Williams Erik A. , McLean Anne C. , Gagan Jeffrey , Rooper Lisa M. , Jordan Richard C. K. , LeBoit Philip E. 
Published: June 2022

AbstractBackgroundMicrosecretory adenocarcinoma (MSA) is a newly described salivary gland neoplasm characterized by MEF2C::SS18 fusions. MSA was previously thought to occur exclusively in salivary glands. Here, we expand the spectrum of known primary sites of this tumor by describing a series of cutaneous tumors with analogous findings.MethodsWe identified four cutaneous primary tumors with histopathologic features identical to MSA of the salivary glands. These cases were evaluated by immunohistochemistry, fluorescence in situ hybridization (FISH) for SS18 rearrangement and targeted RNA‐sequencing. We also queried a pan‐tumor database of advanced carcinomas for MEF2C::SS18.ResultsThe cases occurred in men ranging from 61 to 74 years (mean, 68). They arose from the skin of the nose, chin, scalp, and external auditory canal. All included cords/microcysts of eosinophilic cells with bland oval nuclei and bluish mucin within fibromyxoid stroma. The scalp tumor also exhibited high‐grade transformation (marked atypia, elevated mitotic rate, and necrosis), a feature unreported in salivary MSA. By immunohistochemistry, all cases were positive for S100. Two showed a myoepithelial component positive for p40 and smooth muscle actin or calponin. Three cases harbored MEF2C::SS18 by RNA sequencing, while one with limited tissue had SS18 rearrangement via FISH. Two patients had no evidence of recurrence or metastasis in limited follow‐up (3 and 6 months). The pan‐tumor database query also did not identify MEF2C::SS18 in any advanced cutaneous carcinomas.ConclusionThis report expands the sites that can be involved by MSA. Similar to salivary cases, MEF2C::SS18 represents a recurrent fusion in MSA of the skin. Unusual features in cutaneous cases not seen in salivary MSA include one case with high‐grade transformation and two cases with a myoepithelial cell component. Identification of this fusion expands the spectrum of salivary‐analog cutaneous tumors and aids in precise tumor classification.
Can disorders of subjective time inform the differential diagnosis of psychiatric disorders? A transdiagnostic taxonomy of time
Authors: Kent Lachlan , Nelson Barnaby , Northoff Georg 
Published: June 2022

AbstractAimTime is a core aspect of psychopathology with potential for clinical use and early intervention. Temporal experience, perception, judgement and processing are distorted in various psychiatric disorders such as mood (depression and mania), anxiety, autistic, impulse‐control, dissociative and attention‐deficit/hyperactivity disorders. Can these disorders of time be used as early diagnostic or predictive markers? To answer this question, we develop a Transdiagnostic Taxonomy of (disordered) Time (TTT) that maps on to the symptomatological, phenomenal, perceptual and functional descriptions of each underlying disorder in a 2 × 2 × 2 state space. Temporal distortions may precede functional decline, and so assist efforts at early detection and intervention in at‐risk groups.MethodFirstly, this article integrates a psychological model of how time is processed with a subjective or phenomenological model of how time is experienced or perceived. Secondly, the integrated combined model of time is then used to heuristically map major psychiatric disorders on to the basic elements of temporal flow and integration.ResultsThe TTT systematically describes the basic temporal nature of eight diagnostic categories of psychiatric illness. It differentiates between diagnoses primarily associated with distorted “macro‐level” phenomenal temporal experiences (i.e. anxiety, dissociation/PTSD, depression, and mania) from those primarily related to distorted ‘micro‐level’ temporal processing (i.e. psychotic, impulse‐control, autistic and attention‐deficit/hyperactivity disorders).ConclusionsThe TTT allows differential diagnostic classification of various psychiatric disorders in terms of a possible underlying time disorder, making it useful for future diagnostic and predictive purposes using novel techniques of temporal processing, time perception, passage of time, and time perspective.
Assessment of agreement between EXTEM and NATEM thromboelastometry measurement assays in critically ill neonates
Authors: Tsantes Andreas G. , Konstantinidi Aikaterini , Parastatidou Stavroula , Ioakeimidis Georgios , Tsante Konstantina A. , Mantzios Petros G. , Kriebardis Anastasios G. , Gialeraki Argyri , Houhoula Dimitra , Iacovidou Nicoletta , Piovani Daniele , Bonovas Stefanos , Tsantes Argirios E. , Sokou Rozeta 
Published: June 2022

AbstractObjectivesTo investigate the agreement between the EXTEM and NATEM measurements.MethodsIn this retrospective observational study, EXTEM and NATEM analyses were performed on blood samples from 162 ill neonates, providing 324 paired measurements. The agreement between EXTEM and NATEM measurements was evaluated by the nonparametric spearman's rank correlation to assess the correlation between the paired measurements, by the Bland–Altman analysis for the graphical presentation of the agreement, and by the Deming regression model to assess the significance of the agreement. The agreement between the two methods for the detection of bleeding events was determined by kappa statistic.ResultsStrong correlations were found between EXTEM and NATEM measurements for A10, MCF. The Bland–Altman plots showed good agreement for A10, MCF, LI60, and alpha angle parameters, while CT showed a nearly linear slope indicating that bias increased with the mean. The highest agreement for bleeding events was found for the A10 parameter (κ = 0.70, p < .001), while the lowest for the CT parameter (κ = 0.36, p = .94).ConclusionsNATEM parameters that reflect clot firmness and fibrinolytic activity are strongly correlated with the corresponding EXTEM measurements with a good agreement between them, indicating that these two methods could be used interchangeably.
Random mating for body size despite fitness benefits of size‐assortative mating in a treefrog
Authors: Höbel Gerlinde , Feagles Olivia , Moore Abigail , Reichert Michael , Stratman Kane 
Published: June 2022

AbstractSize‐assortative mating in frogs and toads should increase fitness, because pairs consisting of partners well matched for size should also have a higher proportion of fertilized eggs. We examined whether the size ratios of mated males and females had an effect on fertilization success in Eastern Gray Treefrogs and tested whether the naturally observed size ratios could be attributed to female preferences or stochastic effects (male availability). We show that in this species, mating with a roughly size‐matched partner (m/f size ratios between 0.9 and 1.1) provides direct benefits by increasing fertilization success. Although the frequency of male advertisement calls would provide females with a cue by which to estimate the body size of a potential partner, the female call frequency preferences are not size‐dependent. Call frequency preferences are therefore unlikely to result in the choice of a well‐matched partner. The size distributions of males and females available at the breeding site appear to result in the distribution of male/female size ratios and the weak pattern of size‐assortative mating we observed in nature, despite apparently random mating with respect to body size.
Infection influences vibratory signal components in a wolf spider
Authors: Gilbert Rachel , Uetz George W. 
Published: June 2022

AbstractWhile most research on sexual signals as indicators of health status and infection has been focused on communication by visual (color), airborne acoustic (song structure, amplitude, frequency, and pattern), or chemical means, new evidence suggests that substrate‐borne vibratory signals can also be a reliable indicator of male quality and possibly infection history. In this study, we investigated the ability of the vibratory cues in multimodal sexual signals of Schizocosa ocreata wolf spiders to convey male health information to a female, and whether females adjust their mate choice decisions based on these cues. Individual components of the complete vibratory signal, including stridulatory pulse rate, mean amplitude, and peak amplitude, were all significant predictors of mating success in live trials. Males infected as a juvenile (during the penultimate molt) had significantly lower stridulatory rate and peak amplitude than control males. There were no significant differences in any of the vibratory signal components between control males and males infected as adults (1 h prior to mating trials). This suggests that the vibratory cues in this species may be altered when infection occurs during development, allowing females to avoid males that have been immunocompromised in the past. However, these cues are not reliable indicators of whether a male is actively infected, which means that the evaluation of these cues will not help a female avoid contact with infected individuals. Taken together, these results suggest that vibratory signals may convey honest information about male quality and past health, allowing females to choose mates that have not been compromised during development.
Cooperative robust adaptive control of multiple trains based on RBFNN position output constraints
Authors: Yang Junxia , Zhang Youpeng , Jin Yuxiang 
Published: June 2022

AbstractThe stability of each train, high control accuracy, and minimum safe separation distance are important indexes to measure the performance of the cooperative control system of multiple trains. In this article, aiming at the problem of low accuracy of multiple trains cooperative control with nonlinear running resistance and external disturbance, the distributed cooperative robust adaptive control scheme for multiple trains with RBFNN position output constraints based on train running curve tracking is proposed. Multiple different control techniques are offered for different trains, and that they are based on local knowledge of position, speed, and acceleration. The leading train's speed and position precisely match the planned operation curve, while the following train keeps the tracking interval at the minimum safe distance between two trains. In order to reduce the influence of the uncertainty of basic resistance parameters and external interference on the cooperative control of multiple trains, the parameter uncertainties are compensated by adding a robust adaptive law to the multiple trains control based on position output constraints. The lumped exogenous disturbances (additional resistance, external interference, measurement noise, etc.) are estimated using an RBFNN approximator for the unknown term of the cooperative system. The stability of the cooperative operation of multiple trains is confirmed using the Lyapunov stability theorem. The performance of the proposed scheme was evaluated by the cooperative control system of multiple trains in predecessor following (PF) and bidirectional control (BC) modes.
Molecular characterization of insulin receptor (IR) in oriental fruit moth, Grapholita molesta (Lepidoptera: Tortricidae), and elucidation of its regulatory roles in glucolipid homeostasis and metamorphosis through interaction with miR‐982490
Authors: Fang Haibo , Wang Xiu , Liu Xiaoxia , Michaud J. P. , Wu Yanan , Zhang Huaijiang , Li Yisong , Li Zhen 
Published: June 2022

AbstractAs an intermediate molecule in the Insulin/Insulin‐like growth factor signalling pathway (IIS), the insulin receptor (IR) plays vital roles linking nutritional signals to the downstream regulation of metabolic homeostasis, development, metamorphosis, reproduction and stress responses. In the present study, we describe the molecular characteristics of IR in the cosmopolitan fruit boring pest, Grapholita molesta, and its predicted posttranscription regulator miR‐982490, and elucidate its regulatory roles in glucolipid homeostasis and metamorphosis. Phylogenetic and domain analyses indicate that lepidopteran IRs normally cluster within families, and that four main domains are conserved in GmIR and those of other Lepidoptera. Bio‐informatic prediction, synchronic expression profile evaluation and dual luciferase reporter assays indicated negative regulation of GmIR by miR‐982490. Injection of miR‐982490 agomir into fifth instar larvae yielded effects similar to dsGmIR injection, resulting in enhanced levels of trehalose and triglyceride in haemolymph, and reduced pupation success and pupal weight, both of which could be rescued by co‐injection of dsGmIR and miR‐982490 antagomir. We infer that GmIR regulates glucolipid homeostasis and affects G. molesta metamorphosis via interactions with its posttranscriptional regulator miR‐982490. This study expands our understanding of the regulatory network of IIS in insect nutritional homeostasis and development.
miR‐218 affects the ECM composition and cell biomechanical properties of glioblastoma cells
Authors: Grabowska Małgorzata , Kuczyński Konrad , Piwecka Monika , Rabiasz Alicja , Zemła Joanna , Głodowicz Paweł , Wawrzyniak Dariusz , Lekka Małgorzata , Rolle Katarzyna 
Published: June 2022

AbstractGlioblastoma (GBM) is the most common malignant brain tumour. GBM cells have the ability to infiltrate into the surrounding brain tissue, which results in a significant decrease in the patient’s survival rate. Infiltration is a consequence of the low adhesion and high migration of the tumour cells, two features being associated with the highly remodelled extracellular matrix (ECM). In this study, we report that ECM composition is partially regulated at the post‐transcriptional level by miRNA. Particularly, we show that miR‐218, a well‐known miRNA suppressor, is involved in the direct regulation of ECM components, tenascin‐C (TN‐C) and syndecan‐2 (SDC‐2). We demonstrated that the overexpression of miR‐218 reduces the mRNA and protein expression levels of TN‐C and SDC‐2, and subsequently influences biomechanical properties of GBM cells. Atomic force microscopy (AFM) and real‐time migration analysis revealed that miR‐218 overexpression impairs the migration potential and enhances the adhesive properties of cells. AFM analysis followed by F‐actin staining demonstrated that the expression level of miR‐218 has an impact on cell stiffness and cytoskeletal reorganization. Global gene expression analysis showed deregulation of a number of genes involved in tumour cell motility and adhesion or ECM remodelling upon miR‐218 treatment, suggesting further indirect interactions between the cells and ECM. The results demonstrated a direct impact of miR‐218 reduction in GBM tumours on the qualitative ECM content, leading to changes in the rigidity of the ECM and GBM cells being conducive to increased invasiveness of GBM.
Combined anticancer therapy with imidazoacridinone analogue C‐1305 and paclitaxel in human lung and colon cancer xenografts—Modulation of tumour angiogenesis
Authors: Świtalska Marta , Filip‐Psurska Beata , Milczarek Magdalena , Psurski Mateusz , Moszyńska Adrianna , Dąbrowska Aleksandra M. , Gawrońska Małgorzata , Krzymiński Karol , Bagiński Maciej , Bartoszewski Rafał , Wietrzyk Joanna 
Published: June 2022

AbstractThe acridanone derivative 5‐dimethylaminopropylamino‐8‐hydroxytriazoloacridinone (C‐1305) has been described as a potent inhibitor of cancer cell growth. Its mechanism of action in in vitro conditions was attributed, among others, to its ability to bind and stabilize the microtubule network and subsequently exhibit its tumour‐suppressive effects in synergy with paclitaxel (PTX). Therefore, the objective of the present study was to analyse the effects of the combined treatment of C‐1305 and PTX in vivo. In addition, considering the results of previous genomic analyses, particular attention was given to the effects of this treatment on tumour angiogenesis. Treatment with C‐1305 revealed antitumor effect in A549 lung cancer cells, and combined treatment with PTX showed tendency to anticancer activity in HCT116 colon cancer xenografts. It also improved tumour blood perfusion in both tumour models. The plasma level of CCL2 was increased and that of PDGF was decreased after combined treatment with C‐1305 and PTX. The experimental results showed that the levels of FGF1, TGF‐β and Ang‐4 decreased, whereas the levels of ERK1/2 and Akt phosphorylation increased in HCT116 tumour tissue following combined treatment with both drugs. The results of in vitro capillary‐like structure formation assay demonstrated the inhibiting effect of C‐1305 on this process. Although previous in vitro and in vivo studies suggested a positive effect of C‐1305 on cancer cells, combined treatment of HCT116 human colon and A549 lung cancer cells with both PTX and C‐1305 in vivo showed that the antitumor activity was restricted and associated with the modulation of tumour angiogenesis.
Optimizing Implementation of Artificial‐Intelligence‐Based Automated Scoring: An Evidence Centered Design Approach for Designing Assessments for AI‐based Scoring
Authors: Ercikan Kadriye , McCaffrey Daniel F. 
Published: June 2022

AbstractArtificial‐intelligence‐based automated scoring is often an afterthought and is considered after assessments have been developed, resulting in nonoptimal possibility of implementing automated scoring solutions. In this article, we provide a review of Artificial intelligence (AI)‐based methodologies for scoring in educational assessments. We then propose an evidence‐centered design framework for developing assessments to align conceptualization, scoring, and ultimate assessment interpretation and use with the advantages and limitations of AI‐based scoring in mind. We provide recommendations for defining construct, task, and evidence models to guide task and assessment design that optimize the development and implementation of AI‐based automated scoring of constructed response items and support the validity of inferences from and uses of scores.
Does diet influence aging? Evidence from animal studies
Authors: Le Couteur David G. , Raubenheimer David , Solon‐Biet Samantha , de Cabo Rafael , Simpson Stephen J. 
Published: June 2022

AbstractNutrition profoundly influences the risk for many age‐related diseases. Whether nutrition influences human aging biology directly is less clear. Studies in different animal species indicate that reducing food intake (“caloric restriction” [CR]) can increase lifespan and delay the onset of diseases and the biological hallmarks of aging. Obesity has been described as “accelerated aging” and therefore the lifespan and health benefits generated by CR in both aging and obesity may occur via similar mechanisms. Beyond calorie intake, studies based on nutritional geometry have shown that protein intake and the interaction between dietary protein and carbohydrates influence age‐related health and lifespan. Studies where animals are calorically restricted by providing free access to diluted diets have had less impact on lifespan than those studies where animals are given a reduced aliquot of food each day and are fasting between meals. This has drawn attention to the role of fasting in health and aging, and exploration of the health effects of various fasting regimes. Although definitive human clinical trials of nutrition and aging would need to be unfeasibly long and unrealistically controlled, there is good evidence from animal experiments that some nutritional interventions based on CR, manipulating dietary macronutrients, and fasting can influence aging biology and lifespan.
“It's Not the Stereotypical 80s Movie Bullying”: A Qualitative Study on the High School Environment, Body Image, and Weight Stigma
Authors: Plummer Rachel S. , Alter Zanny , Lee Rebekka M. , Gordon Allegra R. , Cory Hannah , Brion‐Meisels Gretchen , Reiner Jennifer , Topping Kimm , Kenney Erica L. 
Published: June 2022

ABSTRACTBackgroundSchools are crucial for preventing negative health outcomes in youth and are an ideal setting to address weight stigma and poor body image. The current study sought to examine and describe the nature of weight stigma and body image in adolescents, ascertain aspects of the school environment that affect body image, and identify recommendations for schools.MethodsWe conducted 24 semi‐structured interviews with students at 2 high schools in 2020. Qualitative data were analyzed using inductive coding and an immersion/crystallization approach.ResultsStudents did not report weight discrimination or harmful body image messaging from teachers or administrators. Physical education (PE) class and dress codes were 2 instances where covert weight stigma appeared. The most common forms of peer weight stigma reported were weight‐based teasing and self‐directed appearance critiques. Students recommended that schools eliminate dress codes, diversify PE activities, address body image issues in school, and be cognizant of teasing within friend groups.ConclusionsWeight stigma presents itself in unique ways in high school settings. Schools can play a role in reducing experiences of weight stigma and negative body image. Weight‐related teasing within friend groups was common and may not be captured in traditional assessments of bullying. More nuanced survey instruments may be needed.