bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic compression locking system vs. dynamic hip screw in the treatment of femoral neck fractures: A comparative study
Authors: Chang Jian-Zhong , Xiao Ya-Ping , Li Ling , Bei Ming-Jian 
Published: March 2022

Abstract
Background: There is still a lack of consensus on which internal fixation method can better maintain the stability of femoral neck fractures (FNF), promote fracture healing, and avoid and reduce postoperative complications such as femoral head necrosis and nonunion. Therefore, the purpose of this study was to evaluate the clinical efficacy of the novel dynamic compression locking system (DCLS) versus dynamic hip screw (DHS) in the treatment of FNF.Methods: Fifty cases of FNF admitted from July 2018 to December 2020 were retrospectively analyzed. According to different treatment methods, they were divided into DCLS group (26 cases) and DHS group (24 cases). Baseline data, intraoperative and postoperative clinical data, complications, and Harris score were collected to evaluate the clinical efficacy. Results: All patients were followed up for 24 months, all of which were caused by falls. The baseline data of the two groups were comparable (P>0.05). There were not significant differences in the length of hospital stay and mobility between the two groups (P>0.05). The operation time, blood loss, incision length, fluoroscopy times and the degree of femoral neck shortening in the DCLS group were significantly less than those in the DHS group (all P<0.05). Harris score in the DCLS group was significantly higher than that in the DHS group (P<0.05). Complications of femoral head necrosis and nonunion in the DHS group were slightly higher than those in the DCLS group, but there was not statistical significance (P>0.05). Conclusion: DCLS is superior to DHS in the treatment of FNF, with advantages of less surgical trauma, simplified surgical procedures, lower radiation exposure dose for patients, good stability of internal fixation and better control of femoral neck shortening. However, there is not significant difference in fracture healing complications, which requires further study.
Association of mutation in the PRKAG2 with familial left ventricular non-compaction cardiomyopathy
Authors: Zhang Jing , Han Xiu , Lu Qun , Ma Aiqun , Wang Tingzhong 
Published: March 2022

Abstract
Left ventricular non-compaction cardiomyopathy (LVNC) is one of the most common inherited cardiovascular diseases. The genetic backgrounds of most LVNC patients are not fully understood. We collected clinical data, family histories, and blood samples and performed genetic analysis using next-generation sequencing (NGS) from a Chinese family of 15 subjects. Clinically LVNC affected subjects showed marked cardiac phenotype heterogeneity. We found that these subjects with LVNC carried a missense heterozygous genetic mutation c.905G༞A(p. R302Q) in γ2 subunit of AMP-activated protein kinase (PRKAG2) gene through NGS. Individuals without this mutation showed no symptoms or cardiac structural abnormalities related to LVNC. One subject was the victim of sudden cardiac death. To sum up, PRKAG2 mutation [c.905G༞A (p. R302Q)] caused familial LVNC. Our results described a potentially pathogenic mutation associated with LVNC, which may further extend the spectrum of LVNC phenotypes related to PRKAG2 gene mutations.
Monitoring hemoglobin levels in human blood samples using an MXene-ZnO-graphene based Surface plasmon resonance biosensor
Authors: Manavalan Balamurugan Alagar , Kuppusamy Peramandai Govindasamy , Uniyal Arun , Pal Amrindra , Karki Bhishma 
Published: March 2022

Abstract
The main aim of our present study is to propose a surface plasmon resonance-based biosensor design for hemoglobin concentration monitoring in human blood samples. The proposed SPR sensor is based upon the Kretschmann configuration with silver metal, MXene, ZnO, and graphene nanolayers, with a BK7 coupling prism. A He-Ne laser optical input source with a 633 nm wavelength is used following the attenuated total reflection (ATR) principle. After employing the MXene, ZnO, and graphene layers over the conventional sensor setup, an investigation is done. With the optimized structure, our main aim is to detect the presence of hemoglobin concentration in the human blood with its refractive index variation. The calculated highest sensitivity of the proposed configuration is 154 \(Degree/RIU\) with the other parameters calculated as FWHM near \(3.69 Degree\), SNR of 0.5051 \({\text{D}\text{e}\text{g}\text{r}\text{e}\text{e}}^{-1}\) and quality factor of 41.58 \({RIU}^{-1}\).
Control of dumbbell satellite orbits using moving mass actuators
Authors: Pilipchuk Valery , Shaw Steve , Chalhoub Nabil 
Published: March 2022

Abstract
Possible principles of a moving mass control of the orbital parameters of an artificial satellite are discussed in the present paper. The satellite is assumed to have a dumbbell shape such that both massive parts can spin and change their relative distance upon the orbital angle according to the suggested control strategy. The latter aims at maintaining a desired satellite size and orientation with respect to the orbital radius in order to take advantage of the variations in the gravitational field along the elliptical orbit. The eccentricity of the orbit along with the energy and angular momentum of the satellite can be shown to gradually vary in an adiabatic way. In particular, the results demonstrate that the parameter of total orbital energy can follow a prescribed temporal profile by controlling the satellite orientation on the orbit to accurately track its desired target. The results from both analytical estimates and numerical integration appear to be in sufficient agreement.
A Golden Thread approach to transforming Maternal and Child Health in Singapore
Authors: Yap Fabian , Loy See Ling , Ku Chee Wai , Chua Mei Chien , Godfrey Keith M. , Chan Jerry Kok Yen 
Published: March 2022

Abstract
Maternal and child health (MCH) in Singapore is currently entering a new phase, with challenges different to those faced 50 years ago. The advancement of medical technologies and access to MCH resources have led to a dramatic fall in maternal and infant mortality rates. However, there has been a steep rise in the rates of obesity and related metabolic diseases. Alongside this is an emerging mental wellness challenge, with one in ten women experience depression across pre-, during and post-pregnancy. Maternal obesity and mental disorders before and during pregnancy not only increase a woman’s risk of pregnancy complications, but also program increased risks in the offspring of childhood obesity, behavioral disorders and later life metabolic disease, catalyzing vicious cycles of disease. Thus, there is a pressing need to transform the current MCH system to address a burgeoning metabolic and mental health challenge for Singapore. Initiating interventions during preconception and continuing into the postpartum has the potential to confer long-term maternal-child benefits, promoting virtuous cycles of health. However, the current MCH system emphasizes antenatal care and lacks focus on the equally, if not more important, preconception, postpartum and inter-pregnancy stages. We describe a new model-of-care framework that integrates a life-course approach to health across preconception, pregnancy and postpartum phases, with the social-ecological model comprising individual, interpersonal, institutional, community and policy as the major targets for health promotion interventions. This “golden thread” approach is being established at the Singapore KK Women’s and Children’s Hospital (KKH), to address both metabolic and mental health challenges to achieve the goal of a thriving, healthy nation. This new model-of-care is set up in KKH as a pilot program known as Healthy Early Life Moments in Singapore (HELMS). HELMS will reach out to women planning to conceive through coordinated interventions across preconception, pregnancy and postpartum periods. A mobile health platform is being developed to facilitate interventions and engage participants in the program through a digital, personalized and interactive approach. This new model-of-care is designed to secure a population with healthy life cycles, by influencing each life-course, early-in-life, to provide the best start for generations to come.
Lrg1 inhibits the activation of hepatic macrophages to alleviate NAFLD by enhancing TGF-β1 signaling
Authors: XU LONGFEI , HAN JING , YANG ZHE , YANG YANPING , CHEN JINHUI , WU XIJUN , HONG YAN , Wang Qi 
Published: March 2022

Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is caused by excessive hepatic lipid deposition, and is characterized by hepatocyte steatosis, the accumulation of immune cells and the increased expression of inflammatory factors. Hepatic macrophages are the main hepatic immune cells, which play a decisive role in NAFLD. The inhibition of the M1 polarization of hepatic macrophages or the depletion of hepatic macrophages can alleviate hepatic steatosis and inflammation.Methods and Results: NAFLD mouse model was established by feeding high fat diet (HFD) for 16 weeks, the expression of Lrg1 in liver tissues was detected by Real-time PCR and Western blot. Then expression of Lrg1 in steatotic hepatocytes was detected by Real-time PCR and Western blot. Finally, Western-blot analysis, Real-time PCR, HE staining and immumohistochemical staining were performed to confirm the Lrg1 inhibits the activation of hepatic macrophages to alleviate NAFLD by enhancing TGF-β1 signaling. The results of present study demonstrated that Lrg1 inhibited the polarization of M1 liver macrophages induced by steatotic hepatocyte-derived conditioned medium by enhancing TGF-β1 signaling, and Lrg1 also alleviated liver inflammation induced by a high-fat diet (HFD) via TGF-β1 signaling. In addition, the expression level of Lrg1 was significantly decreased in liver tissues from mice with HFD-induced steatosis. Conclusion: Our findings identify that HFD-induced hepatic expression of Lrg1 was significantly downregulated，Lrg1 inhibits the infiltration of hepatic macrophages to alleviates fatty liver inflammation through enhancing TGF-β1 signaling.
Quinolinic acid induces alterations in neuronal subcellular compartments, blocks autophagy flux and activates necroptosis and apoptosis in rat striatum.
Authors: Silva-Islas Carlos Alfredo , Santana-Martinez Ricardo Alberto , León-Contreras Juan Carlos , Barrera-Oviedo Diana , Pedraza-Chaverri Jose , Hernandez-Pando Rogelio , Maldonado Perla 
Published: March 2022

Abstract
Quinolinic acid (QUIN) is an agonist of N-methyl-D-aspartate receptor (NMDAr) used to study excitotoxicity in animal models. Striatal QUIN administration increases intracellular Ca2+ and oxidative stress, induces cellular damage and activates different mechanisms of cellular death. There is evidence indicating that impairment in autophagy at early times contributes to cellular damage in excitotoxicity; however, the status of autophagy in QUIN model at 7 days remain unexplored. In this study, the ultrastructural analysis of subcellular compartments and the status of autophagy in the striatum of rats administered with QUIN (120 and 240 nmol) was performed at 7 days. QUIN induced motor behavior impairment, tissue neurodegeneration and cellular damage; moreover, promoted swollen mitochondrial crests, spherical-like morphology and mitochondrial fragmentation. QUIN decreased ribosomal density in the rough endoplasmic reticulum and myelin sheaths discontinuity in axons with separation of the compact lamellae. Furthermore, QUIN induced increase and decrease in ULK1 and p-70-S6K phosphorylation, respectively, suggesting autophagy activation; however, the increased microtubule-associated protein 1A/1B-light chain 3-II (LC3-II) and sequestosome-1/p62 (SQSTM1/p62), and decreased in Beclin 1 and mature cathepsin D also indicates a blockage in autophagy flux. Additionally, QUIN administration increased tumor necrosis factor alpha (TNFα) and receptor-interacting protein kinase 3 (RIPK3) as well as decreased B-cell lymphoma 2 (Bcl-2) and increased in Bcl-2-associated X protein (Bax) levels and c-Jun N-terminal kinase (JNK) phosphorylation, suggesting an activation of necroptosis and apoptosis, respectively. These results indicate that QUIN caused subcellular compartments alteration, a blockage autophagy flux and activated necroptosis and apoptosis at 7 days.
Prediction of ALRTI caused by HRSV infection in Zhengzhou area in seasonal ARIMA model
Authors: Zhang Guang-chao , Sun Xiao-min , Chen Dan , Guo Qing , Ren Yanhong 
Published: March 2022

Abstract
Objective The seasonal trend of ARIMA product was used to predict the incidence of HRSV infection in Zhengzhou area and to explore the application of the model in predicting the incidence rate of ALRTI caused by HRSV infection in ARIMA.Methods Based on the time series construction model of ALRTI incidence rate from January 2018 to January 2020, the incidence rate of ALRTI caused by HRSV infection from January 2021 to January 2022 was verified by HRSV, and the results were validated.Results Model of ALRTI (1,0,1) (0,1,1) 12 is the best model, with BIC = 8.319, Ljung-Box = 20.787, P = 0.160. The average relative error of predicted and actual values of ALRTI incidence rate from March 2021 to January 2022 is 339.33%, and the actual value is within 95% confidence interval of the predicted value.Conclusion In predicting ALRTI caused by HRSV infection, ARIMA model can better predict the trend of incidence, and its effect needs to be further optimized.
Knowledge of the public about the role of lumbar puncture in the diagnosis of Alzheimer's disease in China
Authors: Guo Xiaojuan , Gao Ling , Jin Jiaoting , Liu Jie , Lu Wenhui , Wang Jin , Qu Qiumin 
Published: March 2022

Abstract
Background: Lumbar puncture for cerebrospinal fluid (CSF) detection has not been widely used in clinical practice in China. The aim of this study was to investigate the knowledge of the public about the role of lumbar puncture in the diagnosis of Alzheimer's disease (AD).Methods: A questionnaire survey was conducted using the "Sojump" application. The participants followed the instruction to answer the questionnaire on mobile phone. The survey included the demographic data of the participants, the knowledge about the role of lumbar puncture in the diagnosis of AD, the reasons to decide to undergo lumbar puncture examination. Univariate analysis and multivariate logistic regression analysis were used to investigate the factors associated with the decision. Results: A total of 1050 valid questionnaires were collected, including 403 (38.4%) non-medical staff and 647 (61.6%) medical staff. A total of 862 participants (82.1%) were willing to undergo lumbar puncture, of whom 508 (58.9%) considered that it was helpful to confirm the diagnosis. Multivariate analysis showed that the factors associated with willingness in non-medical staff included: age (OR=0.963, P=0.003, 95% CI: 0.939-0.987), education level (OR=2.073, P=0.037, 95% CI: 1.044-4.114), monthly income (OR=1.340, P=0.031, 95% CI: 1.028-1.748), and occupation type (OR=1.569, P=0.038, 95% CI: 1.026-2.400). The factors associated with willingness in medical staff included: residence (OR=9.182, P=0.036, 95% CI: 1.151-73.238), monthly income (OR=4.008, P=0.002, 95% CI: 1.689-9.511), and hospital Level (OR=38.311, P<0.001, 95% CI: 14.323-102.478).Conclusions: In the general population, more than 80% of people were willing to undergo lumbar puncture for AD diagnosis. However, the desire for the lumbar puncture depends on age, education level, economic status and occupation type.
The association between wheelchair sports participation and quality of life in individuals with physical disabilities
Authors: Bochkezanian Vanesa , Hill Mitchell G , Pederick Katarina , Ledger Sean J 
Published: March 2022

Abstract
Purpose: To investigate the association between wheelchair sports and quality of life among individuals with physical disabilities living in Australia. Methods: 54 participants aged 18-65 years with physical disabilities completed an online survey. The survey contained the WHOQOL-BREF as the primary outcome measure to assess the quality of life in participants.Results: Participants consisted of 16 females (30%), 37 males (69%) and one who identified as other (1%). Of the 54 participants, 31 (57%) lived in a metropolitan area and 23 (43%) lived in a non- metropolitan area. The total number of participants who actively participated in wheelchair sports (Group 1) was 31 (57%), whilst 23 (43%) did not actively participate in any wheelchair sport (Group 2). Of the 54 participants, 42 (78%) had reported barriers to participation. There was a higher, but non-significant difference (6.9, 95%CI -3.8, 17.6, p=0.20) in quality of life scores between those participating in wheelchair sport (61.1±16.9) and those who did not (54.2±20.8). Discussion: This study showed that there was a positive relationship between participation in wheelchair sports and improved quality of life. The findings of this study were consistent with previous research that concluded that regular physical activity had a positive influence on an individual’s quality of life. Scores were higher in those who actively participates in wheelchair sports. Overall, the results from this study found a positive association between participation in wheelchair sports and increased quality of life.
Factors Influencing Organic Food Purchase of Young Indian Consumers
Authors: Mahongnao Mirinchonme , Varah Franky , Varah Sophayo Khamrang 
Published: March 2022

Abstract
As organic food consumption rises throughout the world, there is a greater need for study on the factors that influence organic food consumption. Previous research yielded mixed results and failed to present a complete picture of organic food consumers in India. The goal of this study is to figure out what factors influence young Indian consumers' desire to buy organic foods. A comprehensive questionnaire study of Indian young consumers aged 15 to 30 years old was created in order to examine the relationship between the established key factors. Data was acquired from 289 young Indian customers in New Delhi, India, using a self-administered structured questionnaire. The findings show that young consumers’ organic food purchase intention is largely determined by their environmental concern, product quality, and social pressure. However, the impact of health consciousness, fear, trust, and price, on organic food purchase intention has been found insignificant. The findings have ramifications for organic food producers, marketers, and policymakers in India who are working to increase organic food consumption.
Visual oscillation effects on dynamic balance control in people with multiple sclerosis
Authors: Riem Lara , Beardsley Scott A. , Obeidat Ahmed Z. , Schmit Brian D. 
Published: March 2022

Abstract
Background: People with multiple sclerosis (PwMS) have balance deficits while ambulating through environments that contain moving objects or visual manipulations to perceived self-motion. However, their ability to parse object from self-movement has not been explored. The purpose of this research was to examine the effect of medial-lateral oscillations of the visual field and of objects within the scene on gait in PwMS and healthy age-matched controls using virtual reality (VR).Methods: Fourteen PwMS (mean age 49 ± 11 years) and eleven healthy controls (mean age: 53 ± 12 years) participated in this study. Dynamic balance control was assessed while participants walked on a treadmill at a self-selected speed while wearing a VR headset that projected an immersive forest scene. Visual conditions consisted of (1) no visual manipulations (speed-matched anterior/posterior optical flow), (2) 0.175 meter mediolateral translational oscillations of the scene that consisted of low pairing (0.1 and 0.31 Hz) or (3) high pairing (0.15 and 0.465 Hz) frequencies, (4) 5 degree medial-lateral rotational oscillations of virtual trees at a low frequency pairing (0.1 and 0.31 Hz), and (5) a combination of the tree and scene movements in (3) and (4).Results: We found that both PwMS and controls exhibited greater instability and visuomotor entrainment to simulated mediolateral translation of the visual field (scene) during treadmill walking. This was demonstrated by significant (p<0.05) increases in mean step width and variability and center of mass sway. Visuomotor entrainment was demonstrated by high coherence between center of mass sway and visual motion (magnitude square coherence = ~ 0.5 to 0.8). Only PwMS exhibited significantly greater instability (higher step width variability and center of mass sway) when objects moved within the scene (i.e., swaying trees).Conclusion: Results suggest the presence of visual motion processing errors in PwMS that reduced dynamic stability. Specifically, object motion (via tree sway) was not effectively parsed from the observer’s self-motion. Identifying this distinction between visual object motion and self-motion detection in MS provides insight regarding stability control in environments with excessive external movement, such as those encountered in daily life.
Biomineralized Ferroptosis-Inducing Nanovaccine Based on Combination of Photothermal Therapy and Checkpoint Blockade for Melanoma
Authors: Ma Siyu , Yang Jie , Fang Tianxu , Zhang Jun , Pan Xiuhua , Wei Yawen , Yang Ning , Liu Zengyi , Shen Qi 
Published: March 2022

Abstract
Background: Until now, treatment of refractory tumors and uncontrolled metastasis has not yet achieved satisfactory therapeutic results due to the immunosuppressive tumor microenvironment. The crucial point is inadequate in vivo immune response after tumor initial cure ablation. Here, we proposed the construction of a photothermal nanovaccine based on biomineralized ovalbumin induced ferroptosis after near-infrared triggering. Fe3+ were chelated inside exogenous antigen ovalbumin by biomineralization, and photosensitizer IR820 was loaded on the outer layer by electrostatic incorporation. Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) checkpoint blockade was combined to offer incomparable opportunities for high-effcient synergistic therapy which consists of ferroptosis, photothermal therapy and cancer immunotherapy.Results: After injection treatment, Fe3+ in the vaccine consumed glutathione (GSH) in cells, affected the expression of GPX4 and initiated Fenton reaction, resulting in ferroptosis, which promoted the immunogenic cell death (ICD). After ICD initiation, released tumor endogenous antigens aroused immune cells activation together with ovalbumin. T cells were successfully recruited and infiltrated into tumor, promising the primary tumor received direct therapy and was effectively suppressed. The photothermal effect was triggered by near-infrared irradiation. Photothermal effect of nanovaccine effectively amplified mild immune response by ferroptosis. With combining with CTLA-4 checkpoint blockade, the related cytokines and other immune indicators all showed increasing levels, which had a significant inhibition effect on distal simulated metastases growth. Conclusion:Fe@OVA-IR820 nanovaccine successfully treated primary and metastatic melanoma with combination therapy. Therefore, we could propose Fe@OVA-IR820 nanovaccine combined checkpoint blockade as a potential therapeutic strategy for melanoma treatment in the future.