bluuebunny/crossref_metadata_2025_split huggingface dataset:
Un cube idéal-typique pour l’étude de la plateformisation de la politique
Authors: Li Vigni Fabrizio 
Published: December 2022

Face à la crise de la démocratie représentative, les plateformes participatives en ligne sont de plus en plus mobilisées par des partis au pouvoir pour partager la prise de décision organisationnelle, administrative, législative et budgétaire avec plus de citoyens et de citoyennes. Les technologies de la participation permettent ainsi de renouveler le débat sur la démocratie Internet et d’interroger la manière dont ces outils reconfigurent les pratiques représentatives et participatives. Pour appréhender les relations complexes entre société, logiciels et matérialité, cet article programmatique propose une approche fondée sur la sociologie politique, la sociologie du numérique et les études des infrastructures. Un cube idéal-typique est proposé pour opérationnaliser cette approche à trois dimensions et pour comparer les différentes plateformes (existantes et à venir) avec cet outil.
Latest Advances in Boron Neutron Capture Therapy for Intracranial Glioblastoma
Authors: Chen Yi-Wei , Mu Pei-Fan , Huang Ting-Yu , Lin Ko-Han , Pan Po-Shen , Chen Jen-Kun , Liu Hong-Ming , Wu Meng-Hao , Chou Fong-In 
Published: December 2022

Objective:
Glioblastoma (WHO classification Grade IV) is a highly malignant brain tumor with a high propensity for recurrence even after standard treatments. Patient death is inevitable, as the available methods are largely ineffective for remediation and treatment once recurrence has occurred. This review presents recent advancements in boron neutron capture therapy (BNCT) that have allowed for its clinical use in treating glioblastoma.

Data Sources:
We retrospectively reviewed the results of clinical trials and articles published in the past 30 years worldwide.

Study Selection:
All included studies addressed the use of BNCT to treat high-grade gliomas, including glioblastoma.

Results:
The development of boron-containing agents exhibiting specificity and improvements in technologies that generate neutron sources have led to the clinical use of BNCT for treating tumors. BNCT involves the delivery of a boron-10-containing drug specifically to tumor cells, followed by irradiation with low-energy thermal neutrons to generate two biologically active particles (helium [α particle] and lithium nuclei). Although these particles are highly effective at destroying cells, their field of destruction is limited to the tumor cells. Therefore, BNCT serves as an excellent mode of targeted particle therapy for tumors, particularly those that are infiltrative. The published articles reviewed here demonstrate the gradual refinement of the BNCT technique and prolonged survival for glioma patients compared to conventional treatments.

Conclusion:
With continued improvements, BNCT may become the first-choice treatment for malignant infiltrative glioblastoma in the near future.
Mental Foramen Morphometrics on Cone-Beam Computed Tomography Determines Sexual Dimorphism
Authors: Chanda Satarupa , Manoj Reema , Santosh Vasavi , Shetty Arvind , Waghmare Mandavi , Bhutani Hemant 
Published: December 2022

Introduction:
Identification of humans during a lifetime, as well as acknowledgment even after death, is an inalienable right and forms the core of human dignity. A pivotal step in the identification of human remains is sex determination, as age and stature discernment depends on it. Determination of sex from unknown skeletal remains is extremely challenging, especially when fragmented bony remains are available. Among the various morphological landmarks of the mandible, the mental foramen is considered to be one of the most stable that can be used in sex authentication. Hence, it was used to identify a sexual dimorphism in a mixed Indian population in the present study.

Materials and Methods:
Two-hundred cone-beam computed tomography (CBCT) scans were selected from the archival database and analysed for the present study using morphometric features of the mental foramen i.e., the measurement of: The distance from the superior border of the mental foramen to the inferior border of the mandible (SLM), The distance from the inferior border of the mental foramen to the inferior border of the mandible (ILM) and the distance from the superior border of the mental foramen to the inferior border of the mental foramen (VD).

Results:
Females showed a caudal positioning of mental foramen toward the base of the mandible as compared to males. A statistically significant difference was noted in the dimensions of SLM, ILM and VD, with all the three distances being larger in males when compared to females. Logistic regression analysis showed an overall significance of P < 0.0001 and a prediction score of 89%.

Conclusion:
Mental foramen morphometrics on CBCT enables sex determination in the Indian population with a predictive score of 89%.
Comparative Evaluation of Diagnostic Efficacy of Cell Block Versus Aspiration Cytology
Authors: Chaudhary Nikhil , Das Subhashish , Sinha Snigdha 
Published: December 2022

Introduction:
Fine-needle aspiration cytology (FNAC) has certain disadvantages despite being the most commonly used procedure in the initial diagnosis of any swelling. In such cases, a cell block (CB) study can be a valuable adjunct to smears for establishing a more definitive cytopathological diagnosis. Therefore, this study was conducted to evaluate the efficacy of CB with FNAC and to compare the findings of the CB and FNAC with histopathology as the gold standard.

Materials and Methods:
The study was conducted in the department of pathology at our institute. All the cystic/solid lesions sent for fine-needle aspiration, which yielded sufficient material for the CB, were studied along with detailed clinical history.

Results:
Out of 66 cases of FNAC and CB, 35 cases were sent for histopathology. The mean age of the patients was 41.36 years, and female patients were more in number (73%). Benign lesions (71.4%) were more than malignant ones (29.6%). The CB section had more thyroid lesions (31%). The diagnostic accuracy of FNAC was found to be 94.28%, while that of CB was 97.14%.

Conclusion:
Although FNAC is the first line of investigation for mass lesions, and still, to make the best possible use of an aspirate, smears should be used together with CB preparation to provide the best possible morphological and histological diagnosis.
Primary trabeculectomy with mitomycin C in the treatment of medically uncontrolled inflammatory glaucoma and primary open-angle glaucoma
Authors: Said Maha , Wasfi Ehab I. , Abdelazeem Khaled , Soliman Kamel A. , Masood Imran , Fathalla Ahmed M. 
Published: December 2022

Purpose
The aim of this study was to compare the outcomes of primary trabeculectomy (PT) with mitomycin C (MMC) in uveitic glaucoma (UG) and primary open-angle glaucoma (POAG).

Design
This is a retrospective, case–control study.

Patients and methods
We compared the outcomes of PT with 0.02% MMC for 2 min in 60 adult patients with POAG and 60 adult patients with UG, who underwent surgeries between January 2010 and January 2014 at two major hospitals in Birmingham, UK, and were followed up for 5 years. Trabeculectomy in both groups was performed by fornix-based conjunctival dissection.

Results
The patients’ age was 53.6±5.4 years in POAG patients compared with 48.3±9.45 years in UG patients, with a statistically significant difference (P=0.046). The rates of qualified success, complete success, and failure at the first, third, and fifth year postoperatively did not differ significantly between the two groups (P=0.73, 0.71, and 0.37, respectively). The maximum postoperative intraocular pressure (IOP) reduction was observed in the first year, followed by a slow rise in IOP, and the number of antiglaucoma medications until the fifth year postoperatively. The 5-year postoperative IOP differed significantly between the two groups (18.33±2.98 vs. 19.88±3.41 mmHg in the POAG vs. UG, respectively, P=0.009).

Conclusion
The success rate of PT with MMC in UG was not inferior to that in POAG. One-year posttrabeculectomy with MMC, the qualified success rate mildly increased at the expense of the complete success rate while the failure rate remained largely constant, indicating a constant need for additional antiglaucoma medications.
Novel Microsoft Excel spreadsheet calculator for vector analysis of mass astigmatism data and comparison between Alpins and Thibos methods
Authors: Elkadim Mohamed , El-Shehawy Ahmed 
Published: December 2022

Background
Vector analysis is mandatory for reporting astigmatism and for the evaluation of different refractive procedures.

Aim
The aim of this study was to describe and evaluate a new spreadsheet calculator for vector analysis of mass astigmatism data and to compare between Alpins and Thibos methods.

Patients and methods
Using Microsoft Office Excel 2016, a new astigmatic calculator was designed, based on Alpins and Thibos methods of vector analysis. Mass astigmatic data input involved power in diopters and axis direction in degrees. The calculator was investigated on 20 eyes for which photorefractive keratectomy was performed. Preoperative and postoperative manifest refractions were measured. Comparisons were done between the results of Alpins and Thibos methods of analysis.

Results
The mean surgically induced astigmatism (SIA) was 2.547±0.721 D and the change in astigmatism power vector (ΔAPV) calculated with the Thibos method was 1.27±0.36 D. A perfect positive correlation (r=1; P<0.000) was present between SIA and ΔAPV with SIA=2ΔAPV. A perfect positive correlation (r=1; P<0.000) was also present between the index of success and APV ratio.

Conclusion
Vector analysis of mass astigmatism data could be performed using the new Excel calculator. Alpins and Thibos methods showed interchangeability between their results.
Course and outcome of retinopathy of prematurity in babies of multiple pregnancies
Authors: Gaber Raouf , Serag Yasser R. , Elbedewy Hazem A. 
Published: December 2022

Purpose
The aim of this study was to evaluate the course and outcome of retinopathy of prematurity (ROP) in babies of multiple pregnancies (twin and triplet neonates).

Patients and methods
This is a retrospective study in which we reviewed the records of 128 babies (all twin and triplet neonates), who were admitted to the biggest neonatal ICU in El Mahalla El-Kubra City, Gharbeya province, Egypt over the period between January 1, 2019 and July 1, 2021. The clinical information about perinatal neonates was collected. The main outcome measures were incidence, course, and final outcome of ROP in terms of regression (spontaneous or after treatment) or progression. The relationship of the clinical risk factors and the development of ROP were also analyzed.

Results
The overall incidence of ROP in twins and triplets was 36%, which was statistically higher in triplets (24/36=66.6%) than in twins (22/92=24%) (P<0.001). The overall incidence of type 1 ROP was 28%. In 30 pairs of twins (30/46=65%), the course was symmetrical in both babies, while in 16 (35%) pairs, the course and outcome were asymmetrical. In six triplets (6/12=50%) the course was symmetrical, while in the other six (50%) triplets the course was asymmetrical.

Conclusion
ROP can take asymmetrical course in twins and triplets. Even it can happen only in the heavier baby. Therefore, examination of both babies of twins and all babies of triplets is essential in ROP protocols.
To Evaluate the Prevalence, Risk Factors, and Awareness Associated with Diabetic Retinopathy among Admitted Diabetic Patients at a Tertiary Level Hospital in Bihar
Authors: Kumari Pinki , Poonam  , Sinha Umesh Prasad 
Published: December 2022

Introduction:
Diabetic retinopathy (DR) is an emerging cause of blindness in developing countries.

Objectives:
The study aims to evaluate the prevalence, risk factors, and awareness associated with DR among admitted diabetic patients.

Materials and Methods:
A noninterventional case series study was conducted among diabetic patients referred for ophthalmic consultation. The patients’ detailed demographics, awareness of DR, concurrent systemic problems, and glycemic control status were recorded. DR was graded using the Early Treatment DR Study criteria.

Main Outcome Measures:
The prevalence, risk factors, and awareness of DR among the study participants were analyzed.

Results:
A total of 270 diabetic patients were enrolled in the study. The mean age was 62.20 ± 13.24 years. Only one-third (34.4%) of the cases were admitted for sugar control and newly diagnosed cases comprised 19.63%. Dilated fundus evaluation was done for the first time in 44.8%. DR was found in 41.11% of the cases and was diagnosed in 15% of the new cases. More than four-fifths diabetics patients (88%) had the disease for 16-20 years. Clinically significant macular edema was found in 5.19% and proliferative DR in 2.22%. DR was significantly associated with the duration of diabetes (P = 0.001) and concurrent hypertension (P = 0.004).

Conclusion:
DR is a common problem with diabetics in Bihar. The prevalence of DR was 41% among the admitted diabetic cases and the DR was significantly associated with the duration of diabetes and systemic hypertension. Almost half of the cases had been unaware of DR before referral. This emphasizes the importance of the collaboration of the physician and the ophthalmologist for early DR detection.
Feasibility and safety of a new dedicated biliary stent for EUS-guided hepaticogastrostomy: The FIT study (with video)
Authors: Anderloni Andrea , Fugazza Alessandro , Spadaccini Marco , Colombo Matteo , Capogreco Antonio , Carrara Silvia , Maselli Roberta , Ferrara Elisa Chiara , Galtieri Piera Alessia , Pellegatta Gaia , Repici Alessandro 
Published: December 2022

ABSTRACT

Background and Objectives:
EUS-guided biliary drainage (BD) through hepaticogastrostomy (HGS) is an option in case of ERCP failure. Available data suggest that this procedure may be challenging with possible severe adverse events (AEs) mainly due to stent migration. The aim of our pilot study was to prospectively assess the technical and clinical outcomes of EUS-HGS using a new dedicated partially covered self-expandable metal stent with anti-migratory systems.

Methods:
This is a single-center prospective study enrolling patients with malignant biliary obstruction undergoing EUS-HGS after failed ERCP, between June 2020 and March 2021. The primary endpoint was the technical success rate. Evaluation of specific stent-related technical features as compared with commonly used self-expandable metal stent, clinical success rate, and procedure-related AEs was also assessed.

Results:
Twenty-two patients (15%–68.2%, female; mean age, 66.0 ± 10.0) were enrolled in the study analysis. Different causes of ERCP failure were infiltration of papilla by neoplastic tissue (4, 18.2%), unreachable papilla for duodenal stricture (9, 40.9%), surgically altered anatomy with Roux-en-Y reconstruction (4, 18.2%), and incomplete BD after transpapillary stent placement (5, 22.7%). Technical success was achieved in all patients, in a mean procedural time of 43.3 ± 26.8 min. Technical features were graded as high or medium in all cases. The clinical success rate was 91% (20/22, mean follow-up: 10.8 ± 3.1 months). There were no cases of stent misplacement or stent migration. Three (13.6%) cases of a hepatic abscess requiring percutaneous drainage and systemic antibiotics were reported, with no impact on clinical success and following oncologic treatments. No deaths occurred.

Conclusion:
EUS-HGS with a new dedicated stent with anti-migratory systems is feasible and effective, preventing stent migration, and misplacement. Although the persistent procedural challenges, dedicated devices may contribute to outcomes improvement and procedure diffusion.
Comparative evaluation of efficacy of topical and intra-sulcular application of Co-enzyme Q10 in the non-surgical treatment of periodontal diseases
Authors: Dahiya Parveen , Malhotra Asheema , Pajnoo Anushika , Gupta Rajan , Kamal Reet 
Published: December 2022

Background:
Periodontitis is a ubiquitous and irreversible inflammatory condition that affects the supporting structures of teeth, which could lead to tooth loss as well as contribute to systemic inflammation. During the inflammatory phase, there is a release of superoxide ions and reactive oxygen species, which causes an increase in the oxidative stress. To combat this stress, the use of certain antioxidants has been proposed, which will help in maintaining the harmonious equilibrium.

Aim:
The aim of the present systematic review is to investigate the efficacy of topical and intrasulcular application of coenzyme Q10 in nonsurgical treatment of periodontal disease.

Materials and Methods:
We conducted a systematic review on the clinical studies which compared the use of coenzyme Q10 as an adjunct to nonsurgical periodontal therapy. The studies mentioned in this review were in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and met our inclusion criteria – only randomized control trials in humans and literature published between 2000 and 2020 were included.

Results:
Therapies with coenzyme Q10 as an adjunct to scaling and root planing (SRP) proved to show superior improvement by reduction in the clinical parameters (plaque index, gingival index, bleeding on probing, and clinical attachment loss) when compared to SRP alone.

Conclusions:
Adjunctive therapy with coenzyme Q10 provides longer-lasting therapeutic effects and better results when compared with SRP alone. The possibility to use the gel as a sole agent to support standard treatment procedures in periodontitis is also suggested.
Composite outcome measure (COM) and pocket closure as clinical endpoints following treatment of infra bony defects with Guided tissue regeneration and Open flap debridement
Authors: Thayil Sruthy Tom , Pillai Baiju Radhamoni Madhavan , Nafeesa Raseena Beevi , Kalarikkal Roshna Erumbuzhi 
Published: December 2022

Background:
Clinical outcomes of regenerative periodontal therapy has been traditionally assessed using surrogate markers, primarily clinical attachment level (CAL) gain and probing pocket depth (PPD) reduction. This study tried to assess newer clinical endpoints namely pocket closure and composite outcome measure (COM) apart from CAL gain, PPD reduction and gingival recession in patients who underwent guided tissue regeneration (GTR) and compared the same with open flap debridement (OFD) six months post treatment.

Materials and Methods:
Records of 58 sites in 48 patients who had undergone GTR (28 sites) and OFD (30 sites) for infrabony defects were evaluated for CAL gain, PPD reduction, change in GR, FMBS, and FMPS at baseline and 6 months after surgery. Pocket closure and COM were used to assess the efficacy of both treatments.

Results:
Statistically significant improvements were seen in both the groups except GR from baseline to 6 months. GTR-treated sites showed better improvements with a statistically significant difference in CAL gain after 6 months. Pocket closure and percentage of treatment success and failure in both the groups assessed using a COM were similar and did not differ statistically.

Conclusion:
Treatment of infrabony defects with GTR combined with a xenograft offers better CAL gain after 6 months compared to OFD alone and also found that baseline PPD and FMBS were the factors determining pocket closure.
Effect of periodontal treatment on serum inflammatory parameters and disease activity in patients with systemic lupus erythematosus: A randomized controlled trial
Authors: Maybodi Fahimeh Rashidi , Bashiri Hamidreza , Sezavar Kimiya , Owlia Fatemeh 
Published: December 2022

Background:
Several descriptive studies have shown an association between periodontitis and systemic lupus erythematosus (SLE), but clinical trials evaluating the effect of periodontal treatment on serological inflammatory parameters or disease activity in SLE patients are very limited. The aim of this study was to see how periodontal treatment affects the status of SLE patients.

Materials and Methods:
Ninety patients with active SLE and periodontitis were randomly assigned to one of two groups: case (oral hygiene instructions + scaling and root planning) or control (oral hygiene instructions only). Periodontal parameters, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) and SLE Disease Activity Index (SLEDAI) levels were monitored at baseline and 3 months later.

Results:
Periodontal parameters in the case group were significantly reduced both statistically and clinically after 3 months. However, in the control group, these indices decreased statistically (P < 0.05) but not clinically. The score of SLEDAI in both the groups showed a significant downward trend (P < 0.05) from the start of the study, but the differences in this index between the two groups were not statistically significant (P = 0.894). Although there was a significant decrease in CRP and ESR (P = 0.001) after 3 months in the case group, indicating a positive effect of periodontal treatment on inflammation reduction, there was no significant decrease in CRP and ESR in the control group.

Conclusion:
According to our findings, it appears to be no statistically significant association between periodontal treatment and SLEDAI level. However, this treatment seems to be effective in reducing acute phase biomarkers such as CRP and ESR.
Effect of Frame and Fixation Factors on the Incidence of Pin Site Infections in Circular External Fixation of the Tibia
Authors: Laubscher Maritz , Nieuwoudt Luan , Marais Leonard Charles 
Published: December 2022

Introduction:
Pin site infections (PSIs) are frequent complications encountered with the use of circular external fixators. PSIs range in severity, and the numerous factors have been suggested to affect the incidence. We aim to perform a systematic review of all comparative studies including circular external fixation applied to the tibia diaphysis in adult patients and to explore frame and fixation factors that may be associated with the development of PSI.

Materials and Methods:
We conduct a systematic review of the literature according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to assess the available data with the specific focus on frame factors that might contribute to the development of PSI. A literature search of major electronic databases was conducted to identify journal articles. A scoping review process was adopted due to the expected broad variation of studies in our research topic using the PRISMA for Scoping Reviews guidelines.

Results:
The initial electronic database search produced 360 publications. After a review process, only four publications were retained for final analysis. Type of fixation pins and wires, frame fixation configurations, and reconstructive methods were compared in these studies. There are very few clinical studies comparing the different frame and fixation factors that can influence PSI rates in circular external fixation. The available studies reflect a significant degree of bias and confounding, representing a low level of evidence.

Conclusion:
Further research is needed, and with the present paucity of data, it is not possible to make any firm recommendations. Within the same frame construct, it appears that tensioned wires may carry a lower risk of PSI than half-pins.