bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneously Integrate Iron Single Atom and Nanocluster Triggered Tandem Effect for Boosting Oxygen Electroreduction
Authors: Zhai Weijuan , Huang Senhe , Lu Chenbao , Tang Xiannong , Li Longbin , Huang Bingyu , Hu Ting , Yuan Kai , Zhuang Xiaodong , Chen Yiwang 
Published: February 2022

AbstractAtomically nitrogen‐coordinated iron atoms on carbon (FeNC) catalysts are emerging as attractive materials to substitute precious‐metal‐based catalysts for the oxygen reduction reaction (ORR). However, FeNC usually suffers from unsatisfactory performance due to the symmetrical charge distribution around the iron site. Elaborately regulating the microenvironment of the central Fe atom can substantially improve the catalytic activity of FeNC, which remains challenging. Herein, N/S co‐doped porous carbons are rationally prepared and are verified with rich Fe‐active sites, including atomically dispersed FeN4 and Fe nanoclusters (FeSA‐FeNC@NSC), according to systematically synchrotron X‐ray absorption spectroscopy analysis. Theoretical calculation verifies that the contiguous S atoms and Fe nanoclusters can break the symmetric electronic structure of FeN4 and synergistically optimize 3d orbitals of Fe centers, thus accelerating OO bond cleavage in OOH* for improving ORR activity. The FeSA‐FeNC@NSC delivers an impressive ORR activity with half‐wave‐potential of 0.90 V, which exceeds that of state‐of‐the‐art Pt/C (0.87 V). Furthermore, FeSA‐FeNC@NSC‐based Zn‐air batteries deliver excellent power densities of 259.88 and 55.86 mW cm–2 in liquid and all‐solid‐state flexible configurations, respectively. This work presents an effective strategy to modulate the microenvironment of single atomic centers and boost the catalytic activity of single‐atom catalysts by tandem effect.
Single Virus Detection on Silicon Photonic Crystal Random Cavities
Authors: Watanabe Keisuke , Wu Hsin‐Yu , Xavier Jolly , Joshi Lovleen Tina , Vollmer Frank 
Published: February 2022

AbstractOn‐chip silicon microcavity sensors are advantageous for the detection of virus and biomolecules due to their compactness and the enhanced light–matter interaction with the analyte. While their theoretical sensitivity is at the single‐molecule level, the fabrication of high quality (Q) factor silicon cavities and their integration with optical couplers remain as major hurdles in applications such as single virus detection. Here, label‐free single virus detection using silicon photonic crystal random cavities is proposed and demonstrated. The sensor chips consist of free‐standing silicon photonic crystal waveguides and do not require pre‐fabricated defect cavities or optical couplers. Residual fabrication disorder results in Anderson‐localized cavity modes which are excited by a free space beam. The Q ≈105 is sufficient for observing discrete step‐changes in resonance wavelength for the binding of single adenoviruses (≈50 nm radius). The authors’ findings point to future applications of CMOS‐compatible silicon sensor chips supporting Anderson‐localized modes that have detection capabilities at the level of single nanoparticles and molecules.
Minimum thickness of solid concrete floor slab with column line beams to avoid walking vibration discomfort
Authors: Zahid Tazwar Bakhtiyar , Amanat Khan Mahmud 
Published: February 2022

AbstractIn this study, an attempt has been made to evaluate the minimum slab thickness of reinforced concrete (RC) solid floor slab with column‐line beams to minimize vibration discomfort when subjected to human walking‐induced excitation. An elastic time history finite element analysis methodology has been adopted for the study. An intermediate floor panel of a multistory building has been modeled using appropriate material properties, element dimensioning and stiffness modifiers. The developed model was subjected to a walking excitation using a time history function. The finite element modeling and time history analysis scheme has been validated against experimental study described in the design guide by Fanella and Mota. The study was then focused on studying the walking‐induced vibration characteristics of the floor slab using the span length and slab thickness as the study parameters. The acceleration data obtained for the central point of the slab was subjected to fast fourier transform (FFT) to convert the response to the frequency domain. Comparisons were then made to obtain the minimum slab thickness for each span length using both frequency and acceleration criteria following ACI serviceability limit and the design guide limit by Fanella and Mota. It was observed that a combination of the two limits were needed to determine the minimum slab thickness. The findings will help engineers to design slabs with adequate thickness to minimize human walking‐induced vibration related discomfort.
Bisphenol F exposure affects mouse oocyte in vitro maturation through inducing oxidative stress and DNA damage
Authors: Ding Zhi‐Ming , Chen Yang‐Wu , Ahmad Muhammad Jamil , Wang Yong‐Sheng , Yang Sheng‐Ji , Duan Ze‐Qun , Liu Ming , Yang Cai‐Xia , Liang Ai‐Xin , Hua Guo‐Hua , Huo Li‐Jun 
Published: February 2022

AbstractBisphenol F (BPF), a substitute for bisphenol A (BPA), is progressively used to manufacture various consumer products. Despite the established reproductive toxicity of BPF, the underlying mechanisms remain to elucidate. This in‐vitro study deep in sighted the BPF toxicity on mouse oocyte meiotic maturation and quality. After treating oocytes with BPF (300 μM), the oocyte meiotic progression was blocked, accentuated by a reduced rate in the first polar body extrusion (PBE). Next, we illustrated that BPF induced α‐tubulin hyper‐acetylation disrupted the spindle assembly and chromosome alignment. Concurrently, BPF resulted in severe oxidative stress and DNA damage, which triggered the early apoptosis in mouse oocytes. Further, altered epigenetic modifications following BPF exposure were proved by increased H3K27me3 levels. Concerning the toxic effects on spindle structure, oxidative stress, and DNA damage in mouse oocytes, BPF toxicity was less severe to oocyte maturation and spindle structure than BPA and induced low oxidative stress. However, compared with BPA, oocytes treated with BPF were more prone to DNA damage, indicating not less intense or even more severe toxic effects of BPF than BPA on some aspects of oocytes maturation. In brief, the present study established that like wise to BPA, BPF could inhibit meiotic maturation and reduce oocyte quality, suggesting it is not a safe substitute for BPA.
Building on Linguistic Strengths: Tenets of a Culturally Sustaining Teacher
Authors: Dunham Heather , Murdter‐Atkinson Jessica , Nash Brady , Wetzel Melissa Mosley 
Published: February 2022

AbstractChanges in the U.S. demographics over the past few decades reflect the growing diversity in American classrooms as more students come to school speaking, reading, or writing two or more languages. By building on students’ full repertoire of linguistic and cultural resources, educators have the potential to transform literacy instruction in multilingual classrooms. This article showcases four tenets of culturally sustaining teaching and details how preservice teachers in a reading practicum enacted these four tenets by recognizing and building on bi/multilingual students’ linguistic and cultural strengths. The article concludes with a discussion of how these enactments suggest new possibilities for literacy educators in similar contexts.
Ultrasonography of the cranial part of the thorax is a quick and sensitive technique to detect lung consolidation in veal calves
Authors: Masset Nicolas , Assié Sébastien , Herman Nicolas , Jozan Thibault , Herry Vincent 
Published: February 2022

AbstractBackgroundIn the veal calf industry, bovine respiratory disease is the main cause of morbidity and mortality. Lung ultrasonography (LUS) is an accurate technique to diagnose bronchopneumonia in calves. Due to the economic constraints faced by the industry, a screening technique able to rapidly examine large numbers of calves is required.ObjectiveTo determine if lung ultrasonography focusing on the cranial part of the thorax (1st to 2nd intercostal space (ICS) on the right and 2nd to 3rd on the left) and/or on the middle part of the thorax (3rd to 5th ICS on the right and 4th to 5th on the left) (alternative techniques) are rapid screening techniques as sensitive as LUS of the entire lung (reference technique) to identify calves with lung consolidation lesions.MethodsData on 300 veal calves aged 33.1 ± 8.0 days and weighing on average 67.5 ± 4.0 kg at LUS from two farms were analysed. Systematic LUS of the entire lung was performed on all calves and a lung consolidation score was given to different parts of the thorax. Agreements between the alternative and the reference techniques were measured by Cohen's κ, McNemar's test and weighted κ.ResultsAgreement between LUS focusing on the cranial + middle part or on the cranial part only of the thorax and the reference technique were almost perfect with a cutoff of 1 cm. The relative sensitivity of these two alternative techniques was high (> 93%).ConclusionLung ultrasonography of the cranial + middle part or on the cranial part only of the thorax are quick and sensitive techniques to identify veal calves with lung consolidation lesions shortly after arrival at the facility.
Ultrasound‐ and nerve stimulation‐guided sciatic and saphenous nerve blocks in a pet rabbit (Oryctolagus cuniculus) undergoing calcaneal fracture repair
Authors: Felisberto Ricardo , Flaherty Derek , Tayari Hamaseh 
Published: February 2022

AbstractThe beneficial effects of performing regional anaesthesia techniques as part of a pre‐emptive analgesic strategy are to improve perioperative analgesia and reduce opioid and general anaesthetic drug requirements. In prey species, an early recovery of voluntary motor function, especially after a regional anaesthesia, is essential for the animal's health and welfare. To reduce motor paralysis, a low volume and concentration of local anaesthetic should be administered close to the targeted nerve. This is the first report of an ultrasound (14 MHz linear probe)‐ and nerve stimulation (0.2 mA; 0.3 second; 2 Hz)‐guided saphenous and sciatic nerve blocks using bupivacaine (0.125%; 0.2 mL/kg per nerve) in a rabbit. Drug consumption, physiological response to surgery and postoperative pain scoring were used to determine block success. The ultrasound‐ and nerve stimulation‐guided sciatic and saphenous nerve blocks could be recommended as part of multimodal pain management in rabbits undergoing appropriate pelvic limb orthopaedic surgeries.
Application of nucleoside or nucleotide analogues in RNA dynamics and RNA‐binding protein analysis
Authors: Zheng Meifeng , Lin Yingying , Wang Wei , Zhao Yu , Bao Xichen 
Published: February 2022

AbstractCellular RNAs undergo dynamic changes during RNA biological processes, which are tightly orchestrated by RNA‐binding proteins (RBPs). Yet, the investigation of RNA dynamics is hurdled by highly abundant steady‐state RNAs, which make the signals of dynamic RNAs less detectable. Notably, the exert of nucleoside or nucleotide analogue‐based RNA technologies has provided a remarkable platform for RNA dynamics research, revealing diverse unnoticed features in RNA metabolism. In this review, we focus on the application of two types of analogue‐based RNA sequencing, antigen‐/antibody‐ and click chemistry‐based methodologies, and summarize the RNA dynamics features revealed. Moreover, we discuss emerging single‐cell newly transcribed RNA sequencing methodologies based on nucleoside analogue labeling, which provides novel insights into RNA dynamics regulation at single‐cell resolution. On the other hand, we also emphasize the identification of RBPs that interact with polyA, non‐polyA RNAs, or newly transcribed RNAs and also their associated RNA‐binding domains at genomewide level through ultraviolet crosslinking and mass spectrometry in different contexts. We anticipated that further modification and development of these analogue‐based RNA and RBP capture technologies will aid in obtaining an unprecedented understanding of RNA biology.This article is categorized under:
RNA Interactions with Proteins and Other Molecules > Protein‐RNA Recognition
RNA Structure and Dynamics > RNA Structure, Dynamics and Chemistry
RNA Methods > RNA Analyses in Cells
On the response of anisotropic elastic bodies described by implicit constitutive relations
Authors: Bustamante Roger , Rajagopal Kumbakonam R. 
Published: February 2022

AbstractIn this short note we derive constitutive relations for the response of elastic solids, which are transversely isotropic and those that have two preferred directions of symmetry wherein the material moduli of the body depend on its density, undergoing small deformations. Such constitutive relations have relevance to the response of rocks, concrete, ceramics, bones, and porous metals. The constitutive relations that we develop reduce appropriately to the classical linearized elastic constitutive relation, when appropriate material moduli are set to zero. The new constitutive relations, when restricted to those that are linear in both the stress and the linearized strain, have terms in addition to those for a classical linearized elastic body, and it would be interesting to investigate the consequence of these additional terms with regard to the response of the body.
Production and decay of the Higgs boson in association with top quarks
Authors: Stremmer Daniel , Worek Malgorzata 
Published: February 2022

Abstract
We report on the calculation of the next-lo-leading order QCD corrections to Higgs boson production and decay in association with top quarks. We consider leptonic decays of top quarks leading to the hadronic process pp → e+νeμ−$$ \overline{\nu} $$

ν
¯

μb$$ \overline{b} $$

b
¯

H(H → X) at the LHC with $$ \sqrt{s} $$

s

= 13 TeV. All resonant as well as non-resonant Feynman diagrams, interferences and off-shell effects are included for the top quark and W gauge boson. Decays of the Higgs boson, on the other hand, are included in the narrow-width approximation. Specifically, we consider Higgs boson decays into b$$ \overline{b} $$

b
¯

, τ+τ−, γγ and e+e−e+e−. Numerical results are given at the integrated and differential fiducial level for various factorisation and renormalisation scale choices and different PDF sets. We study the main theoretical uncertainties that are associated with neglected higher order terms in the perturbative expansion and with different parametrisations of the PDFs. Furthermore, we examine the size of the off-shell effects by an explicit comparison to the calculation in the full narrow-width approximation. Finally, the impact of the contributions induced by the bottom-quark parton density is investigated.
Organoids from human tooth showing epithelial stemness phenotype and differentiation potential
Authors: Hemeryck Lara , Hermans Florian , Chappell Joel , Kobayashi Hiroto , Lambrechts Diether , Lambrichts Ivo , Bronckaers Annelies , Vankelecom Hugo 
Published: February 2022

AbstractInsight into human tooth epithelial stem cells and their biology is sparse. Tissue-derived organoid models typically replicate the tissue’s epithelial stem cell compartment. Here, we developed a first-in-time epithelial organoid model starting from human tooth. Dental follicle (DF) tissue, isolated from unerupted wisdom teeth, efficiently generated epithelial organoids that were long-term expandable. The organoids displayed a tooth epithelial stemness phenotype similar to the DF’s epithelial cell rests of Malassez (ERM), a compartment containing dental epithelial stem cells. Single-cell transcriptomics reinforced this organoid-ERM congruence, and uncovered novel, mouse-mirroring stem cell features. Exposure of the organoids to epidermal growth factor induced transient proliferation and eventual epithelial-mesenchymal transition, highly mimicking events taking place in the ERM in vivo. Moreover, the ERM stemness organoids were able to unfold an ameloblast differentiation process, further enhanced by transforming growth factor-β (TGFβ) and abrogated by TGFβ receptor inhibition, thereby reproducing TGFβ's known key position in amelogenesis. Interestingly, by creating a mesenchymal-epithelial composite organoid (assembloid) model, we demonstrated that the presence of dental mesenchymal cells (i.e. pulp stem cells) triggered ameloblast differentiation in the epithelial stem cells, thus replicating the known importance of mesenchyme-epithelium interaction in tooth development and amelogenesis. Also here, differentiation was abrogated by TGFβ receptor inhibition. Together, we developed novel organoid models empowering the exploration of human tooth epithelial stem cell biology and function as well as their interplay with dental mesenchyme, all at present only poorly defined in humans. Moreover, the new models may pave the way to future tooth-regenerative perspectives.
Olfactomedin-4 improves cutaneous wound healing by promoting skin cell proliferation and migration through POU5F1/OCT4 and ESR1 signalling cascades
Authors: Klaas Mariliis , Mäemets-Allas Kristina , Heinmäe Elizabeth , Lagus Heli , Arak Terje , Eller Mart , Kingo Külli , Kankuri Esko , Jaks Viljar 
Published: February 2022

AbstractOlfactomedin-4 (OLFM4) is an olfactomedin-domain-containing glycoprotein, which regulates cell adhesion, proliferation, gastrointestinal inflammation, innate immunity and cancer metastasis. In the present study we investigated its role in skin regeneration. We found that OLFM4 expression is transiently upregulated in the proliferative phase of cutaneous wound healing in humans as well as in mice. Moreover, a significant increase in OLFM4 expression was detected in the skin of lesional psoriasis, a chronic inflammatory disease characterized by keratinocyte hyperproliferation. In vitro experiments demonstrated that OLFM4 selectively stimulated keratinocyte proliferation and increased both keratinocyte and fibroblast migration. Using proteotranscriptomic pathway analysis we revealed that transcription factors POU5F1/OCT4 and ESR1 acted as hubs for OLFM4-induced signalling in keratinocytes. In vivo experiments utilizing mouse splinted full-thickness cutaneous wound healing model showed that application of recombinant OLFM4 protein can significantly improve wound healing efficacy. Taken together, our results suggest that OLFM4 acts as a transiently upregulated inflammatory signal that promotes wound healing by regulating both dermal and epidermal cell compartments of the skin.
Vibration of an Incompressible viscoelastic shell of rate type
Authors: Farina Angiolo , Fusi Lorenzo , Rosso Fabio , Saccomandi Giuseppe 
Published: February 2022

AbstractWe study the oscillations of a spherical shell of a rate-type viscoelastic solid subject to a pressure difference between the inner and the outer surface. The stable equilibrium configurations, in the class of spherically symmetric deformations, correspond to the minima of the elastic energy function. Numerical simulations indicate that the way in which the equilibrium state is reached, strongly depends on the material parameters.
Social cognitive mechanisms in healthcare worker resilience across time during the pandemic
Authors: Smith Andrew J. , Shoji Kotaro , Griffin Brandon J. , Sippel Lauren M. , Dworkin Emily R. , Wright Hannah M. , Morrow Ellen , Locke Amy , Love Tiffany M. , Harris J. Irene , Kaniasty Krzysztof , Langenecker Scott A. , Benight Charles C. 
Published: February 2022

Abstract
Purpose
Healthcare workers are at increased risk for mental health problems during disasters such as the COVID-19 pandemic. Identifying resilience mechanisms can inform development of interventions for this population. The current study examined pathways that may support healthcare worker resilience, specifically testing enabling (social support enabled self-efficacy) and cultivation (self-efficacy cultivating support) models.

Methods
Healthcare workers (N = 828) in the Rocky Mountain West completed self-report measures at four time points (once per month from April to July of 2020). We estimated structural equation models to explore the potential mediating effects that received social support and coping self-efficacy had (at time 2 and time 3) between traumatic stress symptom severity (at time 1 and time 4). Models included covariates gender, age, minority status, and time lagged co-variations between the proposed mediators (social support and coping self-efficacy).

Results
The full model fit the data well, CFI = .993, SRMR = .027, RMSEA = .036 [90% CIs (0.013, 0.057)]. Tests of sequential mediation supported enabling model dynamics. Specifically, the effects of time 1 traumatic stress severity were mediated through received social support at time 2 and time 3 coping self-efficacy, in sequential order to reduce time 4 traumatic stress severity.

Conclusions
Findings show the importance of received social support and coping self-efficacy in mitigating psychopathology risk. Interventions can support mental health by focusing on social resource engagement that facilitates coping empowerment, which may decrease risk for mental health job-related problems among frontline healthcare workers exposed to highly stressful events.
Effect of electroacupuncture on the degradation of collagen in pelvic floor supporting tissue of stress urinary incontinence rats
Authors: Li Chaonan , Yang Mengyi , Qu Zhiyu , Ruan Shuoquan , Chen Bingli , Ran Jinchuan , Shu Wen , Chen Yuelai , Hou Wenguang 
Published: February 2022

Abstract
Introduction and hypothesis
To examine the changes induced by electroacupuncture in stress urinary incontinence (SUI) rats, including the urodynamics and collagen degradation-related cytokine molecular biological expression changes, and to explore the effect and mechanism of EA treatment in SUI.

Methods
Female SPF Sprague-Dawley rats were randomly assigned to five groups (n = 10): sham, model, electroacupuncture control, electroacupuncture, and blocker. The leak point pressure (LPP) and maximum bladder capacity (MBC) were measured for each group of rats, and collagen I, collagen III, matrix metalloproteinases (MMPs), and tissue inhibitor of metalloproteinase (TIMPs) in the anterior vaginal wall of rats in each group were determined by reverse transcription-polymerase chain reaction and western blotting. The data were analyzed by one-way analysis of variance or Kruskal-Wallis test.

Results
Electroacupuncture Shenshu (BL23) and Huiyang (BL35) increased the LPP and MBC in SUI rats (P < 0.05). Electroacupuncture treatment significantly increased the protein expression of collagen I and collagen III in the anterior vaginal wall of SUI rats (P < 0.05) and significantly reduced the protein expression of MMP1, MMP2, and MMP9 (P < 0.05).

Conclusions
Electroacupuncture stimulation can alleviate the signs of SUI, and its mechanism is related to the degradation of collagen in the anterior vaginal wall.