bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Nocebo Response in Pharmacologic Treatments of Primary Headache: A Systematic Review and Meta‐Analysis
Authors: Zhang Yu , Xu Yingying , Liu Shuping , Liang Jingjing , Fan Shanghua , Ding Man , Wang Juan , Xiao Zheman 
Published: May 2022

AbstractThe nature and magnitude of nocebo responses in primary headache disorders are still unknown. To assess the distribution and possible predictors of nocebo responses in primary headache treatments, databases, including PubMed, EMBASE, and Cochrane Library were searched from 1988 to December 31, 2020, for parallel‐group, double‐blind, randomized placebo‐controlled trials of pharmacologic treatments of primary headaches. The nocebo responses were calculated using a random effects meta‐analysis model. Subgroup and metaregression analyses were performed to determine the associations of study design and demographic characteristics with nocebo responses. A total of 178 randomized controlled trials that satisfied the inclusion criteria were included. Prophylactic treatments elicited stronger nocebo responses than acute treatments. The majority of nocebo adverse events were mild to moderate in severity, with the nervous and digestive systems being the most commonly affected. There was a strong correlation between the active medication and control groups in terms of adverse events, both quantitatively and qualitatively. Long treatment duration, a high proportion of subjects receiving active medications, multicenter design, North America, high body mass index, women, previous treatment experiences, and a high proportion of patients with migraine headache with aura were all found to be significant positive predictors of nocebo responses, whereas the year of publication was found to be inversely related to them. Nocebo effects should be noticed for their contribution to discontinuation of or lack of adherence to active treatments. Clarifying these nocebo‐related risk factors can aid in their clinical prevention and management.
Biocompatible enhancement of poly(ethylene terephthalate) (PET) waste films by cold plasma aminolysis
Authors: Mora‐Cortes Luis F , Rivas‐Muñoz Areli N , Neira‐Velázquez María G , Contreras‐Esquivel Juan C , Roger Philippe , Mora‐Cura Yesica N , Soria‐Arguello Gustavo , Bolaina‐Lorenzo Ena D , Reyna‐Martínez Ricardo , Zugasti‐Cruz Alejandro , Narro‐Céspedes Rosa I 
Published: May 2022

AbstractBACKGROUNDPoly(ethylene terephthalate) (PET) waste films were treated by cold plasma aminolysis to graft primary amino groups (‐NH2) and the surface biocompatibility of the polymer was improved. Aminated PET waste films were obtained by applying radiofrequency (RF) plasma treatment of either diethylenetriamine (DTA) or ethylenediamine (EDA). Aminolysis was applied during 5, 10 and 15 min at plasma power levels of 150, 175 and 200 W.RESULTSWater contact angle study revealed that the surface of PET waste films became more hydrophilic after plasma treatment, the contact angles decreased as exposure time or plasma power increased. Also, X‐ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR) detected signals related to ‐NH2 functional groups at the surface of treated PET films. In relation to the biocompatibility properties of the aminated PET waste films, most of them, do not present hemolytic problems, but those treated with DTA at 150 W for 10 min (PET‐DTA/150 W‐10 min) showed the least hemolytic effect. On the other hand, it was proved that plasma treatment of PET waste films conferred a sterilization effect against Pseudomonas aeruginosa bacteria.CONCLUSIONSThe biocompatible properties of PET were improved while the material was sterilized due to the ultraviolet radiation and free electrons generated during plasma treatment. These results suggest that aminated PET waste films have the potential to be used in biological or biomedical applications by taking advantage of ecofriendly technology such as cold plasma and the reuse of waste polymers such as PET from purified water bottles. © 2022 Society of Chemical Industry (SCI).
The association of acute COVID‐19 infection with Patient Safety Indicator‐12 events in a multisite healthcare system
Authors: Bhakta Shivang , Pollock Benjamin D. , Erben Young M. , Edwards Michael A. , Noe Katherine H. , Dowdy Sean C. , Moreno Franco Pablo , Cowart Jennifer B. 
Published: May 2022

AbstractBackgroundPatient Safety Indicator (PSI)‐12, a hospital quality measure designed by Agency for Healthcare Research and Quality (AHRQ) to capture potentially preventable adverse events, captures perioperative venous thromboembolism (VTE). It is unclear how COVID‐19 has affected PSI‐12 performance.ObjectiveWe sought to compare the cumulative incidence of PSI‐12 in patients with and without acute COVID‐19 infection.Design, Setting, and ParticipantsThis was a retrospective cohort study including PSI‐12‐eligible events at three Mayo Clinic medical centers (4/1/2020‐10/5/2021).Exposure, Main Outcomes, and MeasuresWe compared the unadjusted rate and adjusted risk ratio (aRR) for PSI‐12 events among patients with and without COVID‐19 infection using Fisher's exact χ2 test and the AHRQ risk‐adjustment software, respectively. We summarized the clinical outcomes of COVID‐19 patients with a PSI‐12 event.ResultsOur cohort included 50,400 consecutive hospitalizations. Rates of PSI‐12 events were significantly higher among patients with acute COVID‐19 infection (8/257 [3.11%; 95% confidence interval {CI}, 1.35%–6.04%]) compared to patients without COVID‐19 (210/50,143 [0.42%; 95% CI, 0.36%–0.48%]) with a PSI‐12 event during the encounter (p < .001). The risk‐adjusted rate of PSI‐12 was significantly higher in patients with acute COVID‐19 infection (1.50% vs. 0.38%; aRR, 3.90; 95% CI, 2.12–7.17; p < .001). All COVID‐19 patients with PSI‐12 events had severe disease and 4 died. The most common procedure was tracheostomy (75%); the mean (SD) days from surgical procedure to VTE were 0.12 (7.32) days.ConclusionPatients with acute COVID‐19 infection are at higher risk for PSI‐12. The present definition of PSI‐12 does not account for COVID‐19. This may impact hospitals' quality performance if COVID‐19 infection is not accounted for by exclusion or risk adjustment.
妊娠中に併発した縦隔原発B細胞性リンパ腫による気道狭窄症のために緊急帝王切開術を行い，ECMOを導入して救命した1例(A case report of fatal airway obstruction due to primary mediastinal B–cell lymphoma during pregnancy requiring cesarian section and ECMO)
Authors: (Kazuaki Shigemitsu) 重光 胤明 , (Aisa Matoi) 的井 愛紗 , (Yosuke Nakaya) 中舎 洋輔 , (Tomoya Yamashita) 山下 智也 , (Ayumu Tsuruoka) 鶴岡 歩 , (Yoshiki Hayashi) 林 良樹 , (Hiroshi Rinka) 林下 浩士 
Published: May 2022

要旨妊娠33週の30歳女性。6週間前から咳嗽が出現し数日前から臥位になれず近医を受診したところ，胸部CTで前縦隔腫瘍が気管と右主気管支とを圧排していたため同日転院となった。搬送時，起坐呼吸で頻脈があった。顔面の浮腫と頸静脈怒張があり，縦隔腫瘍による気道狭窄症と上大静脈症候群と診断した。呼吸苦は急速に進行しており気管挿管と陽圧換気が必要であった。妊娠継続は母体にとってリスクが高いと判断し緊急帝王切開術の方針としたが，術中に換気不全に陥る危険性があったためextra–corporeal membrane oxygenation（ECMO）を待機して手術を開始した。麻酔の導入から児の娩出までは問題なかったが，閉腹の際に換気量を保てず，veno–venous ECMOを導入した。第2病日に生検を行い，迅速病理検査で悪性リンパ腫と診断し化学療法を開始した。第6病日には胸部X線写真で肺野の透過性が改善して従圧式補助調節換気での一回換気量も増加したため，第8病日にECMOを離脱した。その後も化学療法を継続し，第35病日に人工呼吸器を離脱，第85病日に独歩退院となった。初診から3年8か月が経過した現在，再発はない。妊婦が縦隔腫瘍により重篤な呼吸不全を来すことは稀である。救命のためには，緊急帝王切開術の迅速な決断，必要なタイミングでECMOを導入したこと，迅速な病理診断と早期の治療開始が重要であった。
救急外来におけるサーフィン外傷の特徴(Characteristics of surfing injuries at the emergency department)
Authors: (Yusuke Tokida) 時田 裕介 , (Hiroshi Yamagami) 山上 浩 , (Ichiro Sekine) 関根 一朗 , (Kiyomitsu Fukaguchi) 鱶口 清満 , (Hiroyuki Fukui) 福井 浩之 
Published: May 2022

要旨【目的】サーフィン外傷についての報告は諸外国からあるも限られており，傷害予防を実践するに至っていない。また国による海洋条件の違いが，受傷機転や外傷形態に違いがあると予測されるが，我が国での報告は少なく明らかではない。そこで，多くのサーフィン外傷の受診がある当院で受傷機転・部位，傷害形態などの特徴を明らかにし，傷害予防策を検討することとした。【方法】2018年から2019年の2年間にサーフィン中に受傷し当院救急外来を受診した患者の診療録と電話聞き取りから調査を行った。【結果】対象患者は119人，受傷機転はサーフボード接触型88人，非接触型28人，不明3人であった。接触型では鋭利なフィンやノーズが，露出部位である頭部・顔面，四肢へ接触した皮膚損傷が最も多く約6割を占め，過去の諸外国の報告と同様な受傷機転・受傷部位・外傷形態であった。非接触型では着地時の下肢骨折が多く，手術・入院を要する傾向にあった。傷害予防策として，露出部位を最小限としたウェットスーツやヘッドギアの装着，安全性の高いサーフボードの製品導入が望まれる。【結語】鋭利なフィンやノーズが露出部位である頭部・顔面，四肢へ接触した皮膚損傷が最も多く，これまでの報告と同様な受傷機転/部位・外傷形態であった。傷害予防策や軽減化のためのサーフィン関連製品の導入が望まれる。
Form and function in the avian pelvis
Authors: Frank Tanner M. , Dodson Peter , Hedrick Brandon P. 
Published: May 2022

AbstractThe avian pelvis plays a critical role in the hindlimb function of birds, connecting the hindlimb and axial skeleton and serving as the major attachment site for proximal hindlimb musculature. To assess how diversification of locomotor modes in birds has impacted the evolution of avian pelvic morphology, we conducted a two‐dimensional geometric morphometric analysis of bird pelves in dorsal and lateral views from 163 species (n = 261) across Aves. We investigated the relationships among pelvic shape and ecology, phylogeny, and allometry, and conducted disparity analyses to understand how pelvic morphospace has been explored through the diversification of Aves. We found that while phylogeny was correlated with shape, locomotor categories were significantly discriminated in morphospace in phylogenetically corrected analyses, as was pelvic size. Major shape trends across Aves distinguishing locomotor categories included the relative area of the preacetabular versus postacetabular ilium, how squat or narrow the pelvis is, and the extent of the caudal pelvic border. Birds adapted for hind limb‐propelled swimming had particularly distinctive pelves, with narrow, elongated ilia likely useful for holding the hindlimbs close to the body midline and reducing drag. However, ecology and allometry only account for a small proportion of morphological variation, and in general locomotor groups overlapped substantially in morphospace. These results, alongside disparity through time analyses showing widespread convergence in pelvic morphology throughout the Cenozoic, suggest that avian lineages and ecotypes have extensively explored pelvic morphospace, perhaps aided by a loosening of evolutionary constraints following the evolution of forelimb‐powered flight.
Neural network based heuristic fractional order adaptive PID‐controller for eliminating communication time delay in multi‐area LFC
Authors: Saka Mustafa , Gozde Haluk , Eke Ibrahim , Taplamacioglu M. Cengiz 
Published: May 2022

AbstractCommunication of interconnected power system components with each other and with control centers is provided by using various communication links. However, these links can cause significant time delays (TD) depending on the types, distance and conditions of the communication channel. In addition to temporary time delays caused by the time constants of the components due to system failures, this article draws attention to the negative effects that may be caused by permanent communication time delays in particular, as different from the literature. The communication time delays can disrupt the stable operation of power systems and even cause the whole system to breakdown by making it unstable, when combining with other delays. In the study, the fiber‐optic (F/O) links are assumed to commonly use in supervisory control and data acquisition (SCADA) systems and the communication time delays are calculated based on this scenario. However, it is no doubt that less used radio frequency (RF)‐links will create more time delays. Moreover, to eliminate the negative effects of these types of time delays, a novel neural network based‐heuristic fractional order hybrid adaptive proportional‐integral‐derivative (ML‐H‐PIλDμ) controller for multi area load frequency control (LFC) scheme is developed and analyzed.
Organic materials with high P and low C:P ratio improve P availability for lowland rice in highly weathered soils: Pot and incubation experiments
Authors: Rinasoa Seheno , Nishigaki Tomohiro , Rabeharisoa Lilia , Tsujimoto Yasuhiro , Rakotoson Tovohery 
Published: May 2022

AbstractBackgroundPhosphorus (P) deficiency remains a serious problem for lowland rice cultivation in Sub‐Saharan Africa. Locally available organic materials (OM) are potential amendment resources, but they vary widely in nutrient composition. How different OM affect P availability and rice production under different soil types remains poorly understood.AimsWe aimed to determine soil responses to OM application varying in carbon (C) and P contents on P uptake, rice production, and P availability.MethodsA pot experiment with eight different soils from lowland rice fields amended with four different farmer‐produced OM at an equal dose of 7.5 g kg–1 soil; and an incubation experiment with six soils amended with cellulose and two OM applied at the same C dose were conducted.ResultsAn OM associated with high P and low C:P ratio increased shoot biomass and P uptake of rice in all soils by two‐ and threefold, respectively, compared to the control treatment. Low P saturation in soils (low P:Fe in oxalate extract) produced greater OM effects. Shoot biomass and P uptake decreased significantly in one soil with a high P saturation following application of the other three OM. Although increased soil P solubilization was observed with the addition of fresh C, OM effects on P availability were mostly attributed to their direct P supply.ConclusionOM with high P and low C:P ratio is effective in improving P availability for rice in P‐deficient lowland rice soils.
Use of traditional knowledge in weather prediction and averting climate risks: A case study in livestock‐based smallholder farming systems in Sri Lanka
Authors: Siriwardana Amila Nuwan , Samarakone Thusith Semini , Silva Gamameda Liyanage Lalanie Pradeepa , Dematawewa Chandrarathne Mahinda Bandara , Punyawardena Batugedara Vidanalage Ranjith , Marambe Buddhi , Nidumolu Uday , Howden Mark 
Published: May 2022

AbstractBackgroundIntegration of traditional knowledge (TK) to decision making in agriculture is a continued practice of the smallholder farmers in the tropics. There is a knowledge gap in the use of TK in weather or climate prediction by farmers to minimize climate risks. Hence, a field survey was conducted using a pre‐tested questionnaire coupled with key informant discussions. The study focused on the farmers practicing livestock‐based farming systems in Thabbowa village of the north‐western province of Sri Lanka.ResultsAbout 94% of farmers had access to national level weather forecasting (WF); however, 54% were not confident enough of the accuracy of the WF. Only elderly farmers had confidence in predicting the weather using TK. While using the outcome of the production, those elderly have passed the outcome of the TK‐based weather predictions (WP) to the rest of the farmers where 46% of the study sample used such information at some level of decision making in agriculture. However, it was evident that the farmers used TK‐based WP combined with the national level WF for deciding on agricultural operations. Plant phenology, animal behavior and astronomical evidence were the commonly used biotic and abiotic factors in TK for WP. The behavior of birds was the prominent TK‐based animal indicator for short to medium range and seasonal WP.ConclusionThe smallholder farmers need to be strengthened to use national WF with the correct application of TK‐based WP to fulfill the gaps in deciding climate‐adaptation strategies in mixed‐farming systems.
Feasibility of machine‐delivered sequential massage for the management of lymphedema in the head and neck cancer survivor
Authors: Shires Courtney Brooke , Harris Patricia , Dewan Karuna 
Published: May 2022

AbstractBackgroundLymphedema after treatment for head and neck cancer negatively impacts the quality of life and can produce neck tissue stiffness, dysphagia, pain, and swelling. One form of treatment for lymphedema is machine‐delivered sequential lymphedema massage, which is home based and self administered. This study was undertaken to determine economic and system access to home‐based lymphedema therapy and to measure patient‐reported outcomes among those able to access therapy.MethodsThis study is a retrospective cohort study of 84 head and neck cancer patients who met the criteria for referral for home‐based lymphedema treatment. Patients who were able to access lymphedema therapy were surveyed prior to initiation of therapy and again after therapy.ResultsThirty‐five out of 84 patients were approved for home‐based therapy and received the equipment. Medicare denial of coverage (21/84) was the most common cause of the inability to access therapy. Of the 35 patients who accessed therapy, presenting complaints included: stiffness (31), pain (29), dysphagia (20), and swelling (19). The average time from completion of cancer treatment to initiation of lymphedema therapy was 9 months. Thirty‐four (97%) reported compliance with prescribed therapy, 33 (94%) reported reduced fibrosis, and 30 (89%) reported improvement in activities of daily living. All reported symptoms improved with therapy in 30 (86%) patients. Thirty‐two (91%) reported overall satisfaction with home‐based lymphedema treatment.ConclusionsStiffness and pain were the most common complaints of our patients with head and neck lymphedema. Forty‐two percent of patients who were recommended home lymphedema machine use were able to obtain this with cost coverage by their insurance company or by donation from the company. We found a high compliance rate and a highly reported improvement in symptoms with the machine. The only identifiable factor for the patients with less improvement in symptoms was a greater time gap between treatment and initiation of use of home lymphedema machine.Level of evidence2 Retrospective cohort analysis.
Sex Differences for Clinical Correlates of Alzheimer's Pathology in People with Lewy Body Pathology
Authors: Bayram Ece , Coughlin David G. , Litvan Irene 
Published: May 2022

ABSTRACTBackgroundLewy body (LB) dementias have limited clinical diagnostic accuracy because of frequent copathologies contributing to clinical heterogeneity. Although sex differences in clinical prevalence and frequency of pure LB pathology were shown, differences for clinicopathological correlations are less known.ObjectiveThe aim of this study was to determine sex differences for clinical associations of Alzheimer's disease (AD) copathology in those with LB pathology.MethodsData were from National Alzheimer's Coordinating Center for 223 women and 468 men with limbic or neocortical LB, separated into two groups as those with high likelihood and low/intermediate likelihood for LB clinical phenotype based on pathology. Clinical associations of sex and interaction of sex and pathology for the clinical phenotype were analyzed.ResultsMore severe AD copathology was associated with worse cognitive decline and lower likelihood of LB disease clinical phenotype. Women with more severe AD copathology and tau had worse cognitive decline and higher likelihood of AD clinical phenotype than men. Men with more severe AD copathology had lower likelihood of LB clinical phenotype than women. Interaction of sex and pathology was more pronounced in those aged between 70 and 80 years.ConclusionsAD copathology reduces the likelihood of LB clinical phenotype for both women and men; however, men may be at higher risk for LB disease underdiagnosis and women at higher risk for dementia. The use of both LB and AD biomarkers, even when LB or AD pathology is not clinically expected, is necessary for the accurate clinical diagnosis of both LB diseases and AD. © 2022 International Parkinson and Movement Disorder Society.
An x‐band coplanar magic‐T with high power handing
Authors: Guo Long , Shi Yiping , Wang Guangming , Tian Yin 
Published: May 2022

AbstractAn x‐band coplanar magic‐T with high power handing is proposed by combining an H‐plane power divider and an iris for matching in E‐plane. The proposed magic‐T has −15 dB impedance bandwidth in experiment, which is about 23% covering form 8.9 to 11.2 GHz. Furthermore, the isolation is better than 46.2 dB with the typical insertion loss of 0.15 dB in the whole bandwidth with the contribute of the symmetrical structure. Herein, the average power‐handling capability (APHC) could be estimated at 865 W by simulated analysis, since the structure is all‐metal. Excellent correspondence between the simulated and measured results is demonstrated.
Cancer‐associated fibroblasts in pancreatic cancer: new subtypes, new markers, new targets
Authors: Menezes Shinelle , Okail Mohamed Hazem , Jalil Siti Munira Abd , Kocher Hemant M , Cameron Angus J M 
Published: May 2022

AbstractCancer‐associated fibroblasts (CAFs) have conflicting roles in the suppression and promotion of cancer. Current research focuses on targeting the undesirable properties of CAFs, while attempting to maintain tumour‐suppressive roles. CAFs have been widely associated with primary or secondary therapeutic resistance, and strategies to modify CAF function have therefore largely focussed on their combination with existing therapies. Despite significant progress in preclinical studies, clinical translation of CAF targeted therapies has achieved limited success. Here we will review our emerging understanding of heterogeneous CAF populations in tumour biology and use examples from pancreatic ductal adenocarcinoma to explore why successful clinical targeting of protumourigenic CAF functions remains elusive. Single‐cell technologies have allowed the identification of CAF subtypes with a differential impact on prognosis and response to therapy, but currently without clear consensus. Identification and pharmacological targeting of CAF subtypes associated with immunotherapy response offers new hope to expand clinical options for pancreatic cancer. Various CAF subtype markers may represent biomarkers for patient stratification, to obtain enhanced response with existing and emerging combinatorial therapeutic strategies. Thus, CAF subtyping is the next frontier in understanding and exploiting the tumour microenvironment for therapeutic benefit. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Synchronously improved ozone aging resistance and tribological performance of self‐lubricating fabric composites via 2‐mercaptobenzimidazole
Authors: Li Peilong , Zhang Zhaozhu , Chen Zujun , Yang Mingming , Yuan Junya , Jiang Wei 
Published: May 2022

AbstractSelf‐lubricating fabric composite can be used as liner material in plain bearings of aeronautical aircraft. The concentration of ozone in the cruising altitude of aircraft is relatively high and the oxidation of ozone will reduce the tribological property and service life of the self‐lubricating fabric composites. In present work, 2‐mercaptobenzimidazole (MB) was chosen and filled into self‐lubricating fabric composites to improve their ozone aging resistance and wear resistance performance. Characterizations demonstrated that the optimum filling ratio of MB was 4 wt%. The glass transition temperature of resin and decomposition temperature of the composite filled with 4 wt% MB were 96.3 s and 475°C, which increased by 12.6% and 6.7% compared with that of resin and composites without filling MB, respectively. The tribological performance and ozone aging resistance performance of MB reinforced self‐lubricating fabric composites acquired obviously enhancement. The wear rate of MB reinforced self‐lubricating fabric composites after different ozone aging time decreased by 42.4%–61.8% compared with that of composites without filling MB owing to that the addition of MB improved the oxidation resistance and thermal stability of self‐lubricating composites.