bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of An Aloe-Based Polyherbal Formulation in Adults with Functional Constipation: A Randomized, Double-Blind, Placebo-Controlled, Six-Months Clinical Follow-up Trial
Authors: Ghayour Razmgah Gholam Reza , Hosseini Seyed Mousal-Reza , Hajimehdipoor Homa , Saberi Firoozi Mehdi , Kashafroodi Haniye , Ghahremani Zeinab , Sadeghi Seid Mohammad Hasan , Choopani Rasool 
Published: January 2022

The most common functional gastrointestinal problem in the world is functional constipation. "Ayarij-e-Faiqra (AF)" is a polyherbal formula that has been recommended by Persian Medicine as an efficent purgative agent . The purpose of this study was to evaluate the effect of AF on functional constipation using a double-blind, placebo-controlled clinical trial. According to the Rome III classification, 79 adults with functional constipation were included in this trial. The diagnostic criteria were according to the Rome III classification. Patients with constipation symptoms who referred to the traditional medicine clinic of Shahid Beheshti University of Medical Sciences from April 2014 to September 2016 were randomly allocated to the AF and placebo groups. The AF and placebo groups received AF and placebo for three months, respectively and followed up for another three months. During the study, the treatment efficacy was assessed by a questionnaire. AF treatment significantly decreased most of the symptoms by 84% at the end of the first month (p < 0.05) and by 90% at the end of the third month in comparison to placbo group (p < 0.001). However, three months after the end of the intervention, the frequency of constipation symptoms in both groups was not statistically significant. Based on the satisfaction questionnaire, the treatment satisfaction score during the intervention was increased to 9 in the AF group, but no significant difference was found between the two groups three months after the intervention (p > 0.005). Although AF could be beneficial for treating functional constipation without significant side effects, changing patients’ lifestyles has great importance in this process.
NEURODIDÁTICA: NEUROCIÊNCIA PEDAGÓGICA APLICADA AO ATO DE ENSINAR
Authors: Ghedin Evandro Luiz , Montanho da Silva Artemison , Oliveira Peixoto Karolayne Endrea 
Published: January 2022

Este trabalho apresenta uma resenha da obra: CODEA, André. Neurodidática: fundamentos e princípios. Rio de Janeiro: Wak Editora, 2019.
Modern methods for radionuclide diagnosis of tumors and non-tumor pathologies of the brain
Authors: Zelchan R. V. , Medvedeva A. A. , Bragina O. D. , Ribina A. N. , Ryabova A. I. , Chernov V. I. , Choynzonov E. L. 
Published: January 2022

The review analyzes the global experience in the application of nuclear medicine techniques for diagnosis of tumors and non-tumor pathologies of the brain. The main groups of radiopharmaceuticals currently used for imaging of malignant brain tumors and diagnosis of cognitive impairments and neurotransmitter system disturbances by means of single-photon emission computed tomography and positron emission tomography are described.Modern approaches to the application of methods for radionuclide diagnosis in neuro-oncology and neurology are compared, and the main trends in production of new, more specific radiopharmaceuticals for visualizing brain tumors of various degrees of malignancy and diagnosing non-tumor pathologies of the brain are described. The review discusses the advantages and disadvantages of currently used techniques and radiopharmaceuticals for imaging of central nervous system disorders, depending on the clinical situation and specific diagnostic tasks.In addition, the review presents consolidated recommendations of the leading scientific schools in neuro-oncology on the use of nuclear medicine techniques in patients with brain tumors at the stages of treatment and follow-up. The presented article examines the experience of domestic scientific schools in the development of radiopharmaceuticals for neuro-oncology. The features of the development and use of new radiopharmaceuticals in patients with brain tumors and neurodegenerative diseases are highlighted. The review is based on the analysis of literature included in the Scopus, Web of Science, MedLine, The Cochrane Library, EMBASE, Global Health, and RSCI databases.
Effectiveness of antimicrobial therapy for community-acquired pneumonia in real clinical practice
Authors: Uryasev O. M. , Shakhanov A. V. , Korshunova L. V. 
Published: January 2022

Background. Community-acquired pneumonia (CAP) remains one of the most common infectious diseases, occupying an important place in the structure of mortality worldwide.Aim. To evaluate the effectiveness of antimicrobial therapy for community-acquired pneumonia in hospitalized patients in real clinical practice.Materials and methods. A retrospective, observational study was conducted, which included 236 patients hospitalized for community-acquired pneumonia at the Regional Clinical Hospital in Ryazan in 2019. Based on these case histories, an analysis of the effectiveness of the initial empiric antimicrobial therapy was performed.Results. The initial empiric antimicrobial therapy in 73% of cases included administration of ceftriaxone, in 45% of cases – levofloxacin, in 14% of cases – azithromycin. It was found that initial antimicrobial therapy was effective in 58% of patients who did not require replacement for the antibiotic. A need for a change in the treatment regimen was significantly associated with an increase in the length of hospitalization (p < 0.001), heart rate upon admission (p = 0.032), myelocyte count in the complete blood count (p < 0.001), and urea and blood creatinine levels (p = 0.004 and p = 0.044, respectively). The selected antimicrobial therapy regimen was significantly associated with the expected treatment effectiveness (p = 0.039). The choice of levofloxacin in monotherapy or in combination with ceftriaxone was accompanied by a decrease in the relative risk of replacing the antimicrobial, compared with other treatment regimens (odds ratio (OR) = 0.86 (95% confidence interval (CI): 0.55–1.34) and OR = 0.57 (95% CI: 0.37–0.87), respectively).Conclusion. Empiric antimicrobial therapy for community-acquired pneumonia in real clinical practice complies with current recommendations, however, at the same time, its ineffectiveness persists. Respiratory fluoroquinolones are most effective in treating pneumonia in hospitalized patients.
Clinical, radiologic, and morphological diagnosis of hypersensitivity pneumonitis
Authors: Cherniaev A. L. , Kusraeva E. V. , Samsonova M. V. , Avdeev S. N. , Trushenko N. V. , Tumanova E. L. 
Published: January 2022

Aim. To study the relationship between clinical, radiologic, and morphological features in nonfibrotic and fibrotic hypersensitivity pneumonitis.Materials and methods. Clinical symptoms, data of high-resolution computed tomography, parameters of external respiration, and histological changes in the lung tissue obtained via open and transbronchial biopsies were studied retrospectively in 175 patients with hypersensitivity pneumonitis (HP). Statistical analysis was performed using the Statistica software.Results. We found that the clinical error rate in the diagnosis of HP was 84.5%, among pathologists – 92%. Among all the variants of HP, the most common was fibrotic HP. It was shown that non-necrotizing granulomas and giant cells in the cavities of the alveoli, microcells, and interalveolar septa were more typical of nonfibrotic HP. In fibrotic HP, peribronchial fibrosis, smooth muscle metaplasia in fibrotic areas, and the presence of fibroblastic foci in the walls of terminal bronchioles are signs of differential diagnosis with usual interstitial pneumonia. The classical triad of histological signs was observed in 19.2% of patients with nonfibrotic HP and in 5.6% of patients with fibrotic HP.Conclusion. Diagnosis of HP is complex and should be based on a multidisciplinary approach involving clinicians (pulmonologists), radiologists, functional diagnostics specialists, and pathologists. In this case, it is imperative to take into account and identify factors causing development of the disease, as well as the age of patients.
Determination of the Near-Wellbore Pressure Drop for Dual Casing in Hydraulic Fracturing and Refracturing Applications
Authors: Loehken Joern , Yosefnejad Davood , McNelis Liam , Fricke Bernd 
Published: January 2022

Abstract
Due to the increases in completion costs demand for production improvements, fracturing through double casing in upper reservoirs for mature wells and refracturing early stimulated wells to change the completion design, has become more and more popular. One of the most common technologies used to re-stimulate previously fracked wells, is to run a second, smaller casing or tubular inside of the existing and already perforated pipes of the completed well. The new inner and old outer casing are isolated from each other by a cement layer, which prevents any hydraulic communication between the pre-existing and new perforations, as well as between adjacent new perforations.
For these smaller inner casing diameters, specially tailored and designed re-fracturing perforation systems are deployed, which can shoot casing entrance holes of very similar size through both casings, nearly independent of the phasing and still capable of creating tunnels reaching beyond the cement layer into the natural rock formation.
Although discussing on the API RP-19B section VII test format has recently been initiated and many companies have started to test multiple casing scenarios and charge performance, not much is known about the complex flow through two radially aligned holes in dual casings.
In the paper we will look in detail at the parameters which influence the flow, especially the Coefficient of Discharge of such a dual casing setup. We will evaluate how much the near wellbore pressure drop is affected by the hole's sizes in the first and second casing, respectively the difference between them and investigate how the cement layer is influenced by turbulences, which might build up in the annulus.
The results will enhance the design and provide a better understanding of fracturing or refracturing through double casings for hydraulic fracturing specialists and both operation and services companies.
Supervised Learning Predictive Models for Automated Fracturing Treatment Design: A Workflow Based on Algorithm Comparison and Multiphysics Model Validation
Authors: Khan Abdul Muqtadir , BinZiad Abdullah , Al Subaii Abdullah , Alqarni Turki , Jelassi Mohamed Yassine , Najmi Asim 
Published: January 2022

Abstract
Diagnostic pumping techniques are used routinely in proppant fracturing design. The pumping process can be time consuming; however, it yields technical confidence in treatment and productivity optimization. Recent developments in data analytics and machine learning can aid in shortening operational workflows and enhance project economics. Supervised learning was applied to an existing database to streamline the process and affect the design framework.
Five classification algorithms were used for this study. The database was constructed through heterogeneous reservoir plays from the injection/falloff outputs. The algorithms used were support vector machine, decision tree, random forest, multinomial, and XGBoost. The number of classes was sensitized to establish a balance between model accuracy and prediction granularity. Fifteen cases were developed for a comprehensive comparison. A complete machine learning framework was constructed to work through each case set along with hyperparameter tuning to maximize accuracy. After the model was finalized, an extensive field validation workflow was deployed.
The target outputs selected for the model were crosslinked fluid efficiency, total proppant mass, and maximum proppant concentration. The unsupervised clustering technique with t-SNE algorithm that was used first lacked accuracy. Supervised classification models showed better predictions. Cross-validation techniques showed an increasing trend of prediction accuracy. Feature selection was done using one-variable-at-a-time (OVAT) and a simple feature correlation study. Because the number of features and the dataset size were small, no features were eliminated from the final model building. Accuracy and F1 score calculations were used from the confusion matrix for evaluation, XGBoost showed excellent results with an accuracy of 74 to 95% for the output parameters. Fluid efficiency was categorized into three classes and yielded an accuracy of 96%. Proppant concentration and proppant mass predictions showed 77% and 86% accuracy, respectively, for the six-class case. The combination of high accuracy and fine granularity confirmed the potential application of machine learning models. The ratio of training to testing (holdout) across all cases ranged from 80:20 to 70:30. Model validations were done through an inverse problem of predicting and matching the fracture geometry and treatment pressures from the machine learning model design and the actual net pressure match. The simulations were conducted using advanced multiphysics simulations.
The advantages of this innovative design approach showed four areas of improvement: reduction in polymer consumption by 30%, reduction of the flowback time by 25%, reduction of water usage by 30%, and enhanced operational efficiency by 60 to 65%.
A crosscorrelation methodology for in vivo pharmacokinetic study by the trans-scale fluorescent system
Authors: Gu Yueqing , Li Siwen , Lin Qiao , Ma Yi , Qian Lu , Wang Lijun , Wang Xin , Wang Feilong , Zhao Yixin , He Hua , Zhou Fang , Peng Ying , Liu Liwei , Qu Junle , Wang Zhaohui 
Published: January 2022

Abstract

Conventional single-organ-isolation-based pharmacokinetics study is short of time-course information and exists considerable inaccuracy due to the inter-individual differences and characteristic imparities between in vivo and ex vivo tissues/cells. The in vivo time-course and multi-organs study of model drugs in living subjects could afford precise spatio-temporal correlation. Herein, a revolutionized trans-dimensional fluorescence system was home built, with the macro-level detection part for simultaneous pharmacokinetic study in different organs, and one confocal imaging needle for micro-level visualizing cellular uptake of drugs with super-high resolution (0.472 μm). Correlating these simultaneous acquired trans-scale data, an innovative physiologically-based pharmacokinetics (PBPK) model was firstly created for predicting drug disposition in other species. Its accuracy and reliability was firmly supported by the high consistent predicted-data with the real-measured data in mice and in human, respectively. This study provides an innovative methodology and revolutionized instrument for in vivo real-time advancing assessment of druggability.
Parenting Experiences of Cancer Patients with Minor Children and Their Conversations About the Possibility of Death: A Cross-Sectional Web-Based Survey for an Online Cancer Community
Authors: Usui Yuko , Kosugi Kazuhiro , Nishiguchi Yohei , Miura Tomofumi , Fujisawa Daisuke , Uehara Yuko , Kawaguchi Takashi , Izumi Kayo , Takehana Jun , Matsumoto Yoshihisa 
Published: January 2022

Abstract
Purpose
Many cancer patients with minor children experience difficulty when talking about their illness with their children. The aim of this study is to investigate the parenting experiences of cancer patients with minor children and their conversations about the possibility of death.
Methods
A cross-sectional web-based survey was conducted between April and May 2019. Cancer patients with minor children were recruited from among an online peer support group called “Cancer Parents”. The participants were asked to complete a questionnaire about their experiences talking about their illness with their children. The participants were classified into those who disclosed their cancer to their children (“disclosed group”), and those who didn’t disclose (“undisclosed group”). The association between whether they talked with their children about their cancer and their conversations about the possibility of death were examined.
Results
A total of 370 participants were analyzed (80.8% female, median age 43.0 years). The disclosed group (n = 274, 74.1%) wanted to know what their child felt than the undisclosed group (p < 0.001). The undisclosed group didn’t want their children to see their suffering (p = 0.002) and didn’t know how to explain their disease condition ( p < 0.002). Both the disclosed (42.1%) and undisclosed (6.5%) groups told their children about the possibility of death.
Conclusion
This study showed the disclosed group wanted to know their children’s feelings and they tended to have a conversation about the possibility of death with their children, compared to the undisclosed group.
Skeletal and Alveolar Changes in Conventional Rapid Palatal Expansion (RPE) and Miniscrew-assisted RPE(MARPE): a Prospective Randomized Clinical Trial Using Low-dose CBCT
Authors: Chun Joo-Hee , Castro Amanda Cunha Regal , Oh Sunmee , Kim Kyung-Ho , Choi Sung-Hwan , Nojima Lincoln Issamu , Nojima Matilde da Cunha Gonçalves , Lee Kee-Joon 
Published: January 2022

Abstract
Background: This prospective randomized clinical trial aimed to evaluate the short-term effects of rapid palatal expansion (RPE) and miniscrew-assisted RPE (MARPE) on skeletal, dentoalveolar, and periodontal structures in adolescent and young adult patients. Methods: Thirty-six patients (12 men and 24 women) requiring maxillary expansion were randomly allocated to RPE (n=17) or MARPE (n=19) groups. Upon identical (35 turns) amount of expansion, low-dose cone-beam computed tomography images were taken before treatment (T0), immediately after expansion (T1), and after a 3-month consolidation period (T2). Skeletal, dentoalveolar, and periodontal measurements were performed at each time point. Results: A greater increase in nasal width in the molar region (M-NW) and greater palatine foramen (GPF) was observed immediately after expansion (T1-T0) and consolidation periods (T2-T0) in MARPE group (P<0.05). MARPE and RPE groups showed similar dentoalveolar changes except for the maxillary width (PM-MW, M-MW) (P<0.05). Through the expansion and consolidation periods (T2-T0), lesser buccal displacement of the anchor teeth was observed in the MARPE group (PM-BBPT, PM-PBPT, M-BBPT [mesial and distal roots], and M-PBPT) (P<0.05).Conclusions: Both RPE and MARPE groups exhibited significant triangular basal bone expansion and skeletal relapse during consolidation. Under identical amounts of expansion, the MARPE group showed lower decrease in the skeletal, dentoalveolar and periodontal variables after consolidation. The reinforcement of RPE with miniscrews contributes to the maintenance of the basal bone during consolidation period. This evidence can help clinicians decide the appliance design for maxillary expansion, while preventing periodontal side effects, such as buccal bone dehiscence Trial registration: WHO Institutional Clinical Trials Registry Platform (IRB No. KCT0006871 / Registration Date 27/12/2021)
Adding Rituximab to Chemotherapy for Diffuse Large B-Cell Lymphoma Patients in Indonesia: A Cost Utility and Budget Impact Analysis
Authors: Putri Septiara , Setiawan Ery , Saldi Siti Rizny F. , Chandra Levina , Sari Euis Ratna , Megraini Amila , Nadjib Mardiati , Sastroasmoro Sudigdo , Armansyah Armansyah 
Published: January 2022

Abstract
Background
This study aims to estimate the cost-effectiveness and budget impact of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) compared to CHOP for the treatment of patients with diffuse large B-cell lymphoma (DLBCL) in Indonesia.
Methods
We conducted a cost utility analysis using Markov model over a lifetime horizon, from a societal perspective. Clinical evidence was derived from published clinical trials. Direct medical costs were gathered from hospital data. Direct non-medical costs, indirect costs, and utility data were primarily gathered by interviewing the patients. We applied 3% discount rate for both costs and effect. All monetary data are converted into USD (1 USD = IDR 14,000, 2019). Probabilistic sensitivity analysis was performed. In addition, from a payer perspective, budget impact analysis was estimated using price reduction scenarios.
Results
The incremental cost-effectiveness ratio (ICER) of R-CHOP was USD 4,674/LYG and 9,280/QALY. If we refer to the threshold three times the GDP per capita (USD 11,538), R-CHOP could thus be determined as a cost-effective therapy. Its significant health benefit has contributed to the considerable ICER result. Although the R-CHOP has been considered a cost-effective intervention, the financial consequence of R-CHOP if remain in benefit package under National Health Insurance (NHI) system in Indonesia is considerably substantial, approximately USD 66 million with 75% price reduction scenario.
Conclusions
As a favorable treatment for DLBCL, R-CHOP ensures value for money in Indonesia. Budget impact analysis provides results which can be used as further consideration for decision-makers in matters related to benefit packages.
FBLN5 Is an Underlying Common Tumor Suppressor in Breast Cancer and Thyroid Cancer
Authors: XIE Zhao-min , XIAO Ying-sheng , XU Chun-yan , XIE Qin , WANG Wen-de , WANG Zheng-hao , LIANG Yuan-ke , LIN Hao-yu , ZENG De 
Published: January 2022

Abstract
Background: Breast cancer (BC) patients have a greater risk of developing thyroid cancer (TC) than the general population. Similarly, TC patients are more likely to develop BC, suggesting an underlying common etiology. In this study, we sought to identify the potential cross-talking pathway and related molecular mechanisms conferring to the sequential development of BC and TC.Methods: We first used Multiple Primary-Standardized Incidence Ratios (MP-SIR) Program of SEER*Stat to calculate SIR to confirm the relationship between BC and TC. Then the RNA-seq was downloaded from The Cancer Genome Atlas (TCGA). And we built a co-expression network via Weighted Gene Co-expression Network Analysis (WGCNA) and obtained the most significant modules. The key genes were obtained by differential gene expression (DGE) analysis and WGCNA analysis. Furthermore, String database and Cytoscape software were used to construct protein-protein interactions (PPI), and defined the maximum Maximal Clique Centrality (MCC) value as hub gene.Then we performed prognosis analysis on the hub genes and obtained the prognostic genes of BC and TC. Finally, gene set enrichment analysis (GSEA) was used to investigate the molecular pathways associated with prognostic gene expressed both in BC and TC.Results: From the SEER database, we found that the risk of developing BC in TC patients was SIR 1.12, 95% CI [1.07, 1.18], and the risk of developing BC in TC patients was SIR 1.29, 95% CI [1.23, 1.26]. Fifty-nine key genes obtained by differential expression analysis and WGCNA identify that PI3K/AKT was the most enriched pathway in BC and TC. In addition, the Recombinant Fibulin 5 (FBLN5) was shown to be of significant prognostic value for both BC and TC and was down-regulated in BC and TC tissues. GSEA demonstrated that FBLN5 enrichment pathways associated with BC and TC mainly included: B cell receptor signaling pathway, steroid hormone biosynthesis, and pathways in cancer.Conclusions: The PI3K/AKT signaling is most co-enriched pathway in BC and TC. FBLN5 is the most relevant prognostic gene and an underlying common tumor suppressor in both BC and TC, with down-stream pathways involving immunity, hormone biosynthesis and carcinogenesis.