bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptomic analysis of lignocellulose degradation by Streptomyces coelicolor A3(2) and elicitation of secondary metabolites production
Authors: Besaury Ludovic , Fromentin Jean , Detain Julian , Rodrigues Carine Machado , Harakat Dominique , Rémond Caroline 
Published: October 2022

Abstract
Streptomyces coelicolor A3(2) is considered as the model strain among the Streptomyces and has the capacity to produce several natural molecules. Our hypothesis was that cultivation of the strain onto a complex carbon source such as wheat bran (WB) would induce the production of various secondary metabolites due to the presence of complex polysaccharides. A multiapproach has been performed in order to investigate: (1) whether that strain could degrade lignocellulose; (2) which enzymatic and metabolic pathways secondary were over-expressed when grown on WB. The transcriptomic approach showed the expression of several CAZymes significantly expressed when grown on WB such as endoglucanases (encoding for GH74, GH5_8, and GH12) and xylanases (GH11 and CE4 encoding for respectively endo-1,4-beta-xylanase and an acetyl-xylan esterase). Enzymatic activities showed an expression of xylanase (115.3 ± 32.2 mUI/ml) and laccase–peroxidase (101.5 ± 10.9 mUI/ml) during WB degradation by S. coelicolor A3(2). Metabolomics showed that the production of secondary metabolites differed between growth on either glucose or WB as carbon source, which may be correlated to the complexity of carbon compounds within WB, which are similar to the ones encountered in soils and should represent more the in situ carbon conditions which Streptomyces might face off. This opens opportunities for the bioproduction of molecules of interest from WB.
Stability for Serrin’s Problem and Alexandroff’s Theorem in Warped Product Manifolds
Authors: Scheuer Julian , Xia Chao 
Published: October 2022

Abstract
We prove quantitative versions for several results from geometric partial differential equations. Firstly, we obtain a double stability theorem for Serrin’s overdetermined problem in spaceforms. Secondly, we prove stability theorems for Brendle’s Heintze–Karcher inequality respectively constant mean curvature classification in a class of warped product spaces. The key tool is the first author’s recent development of stability for level sets of a function under smallness of the traceless Hessian thereof.
Abdominal surgical trajectories associated with failure to rescue. A nationwide analysis
Authors: Skyrud Katrine , Helgeland Jon , Lindahl Anne Karin , Augestad Knut Magne 
Published: October 2022

Abstract

Objective
The ability to detect and treat complications of surgery early is essential for optimal patient outcomes. The failure-to-rescue (FTR) rate is defined as the death rate among patients who develop at least one complication after the surgical procedure and may be used to monitor a hospital’s quality of surgical care. The aim of this observational study was to explore FTR in Norway and to see if we could identify surgical trajectories associated with high FTR.

Method
Data on all abdominal surgeries in Norwegian hospitals from 2011 to 2017 were obtained from the Norwegian Patient Registry and linked with the National Population Register. Surgical and other postoperative complication rates and FTR within 30 days (deaths occurring in and out of the hospital) were assessed. We identified surgical trajectories (type of procedures—type of complication—dead/alive at 30 days after operation) associated with the highest volume of deaths (high volume of FTR [FTR-V]) and highest risk of death after a postoperative complication.

Results
Of the total 626 052 primary abdominal procedures, 224 871 (35.8%) had at least one complication, which includes 83 037 patients. The most common postoperative complications were sepsis (N = 14 331) and respiratory failure (N = 7970). The high-volume trajectories (FTR-V) were endoscopic retrograde cholangiopancreatography—sepsis—death (N = 294, 13.8%); open colon resections—sepsis—death (N = 279, 28.1%) and procedures with stoma formation—sepsis—death (N = 272, 27%). Similarly, patients operated with embolectomy of the visceral arteries and experiencing postoperative sepsis were associated with an extremely high risk of 30-day FTR of 81.5%. In general, an FTR patient had a higher mean age, an increased rate of emergency surgery and more comorbidity. Hospital size was not associated with FTR.

Conclusion
At a national level, there exist high-volume and high-risk surgical trajectories associated with FTR. These trajectories represent major targets for quality improvement initiatives.
Accelerating improvement: The Pediatric Acute Care Cardiology Collaborative data timeliness project
Authors: Graupe Margaret , Tignor Ashlin , Veneziale Kelly , Jensen Megan , Khadr Lara , Beckstrom Heather , Gister Martin , Hendricks Karen , Madsen Nicolas L , Roberts Frederick , Youngberg Sarah , Schachtner Susan 
Published: October 2022

Abstract

Background
The Pediatric Acute Care Cardiology Collaborative (PAC3) is a learning network focused on improving acute care cardiology patient outcomes. Data submission timeliness is a vulnerability for PAC3 and most clinical registries, directly affecting collaborative benchmarking, quality improvement (QI) and research projects.

Objective
PAC3 conducted a collaborative-wide QI project addressing data timeliness and efficiency. Data analysis of submitted cases from September 2019 to February 2020 revealed nine ‘High Performer’ centers who submitted cases within 67 days of hospital discharge (the limit for timeliness) &gt;90% of the time and eight ‘High Potential’ sites who submitted timely cases &lt;75% of the time. The primary aim was to increase case submission timeliness in ‘High Potential’ centers from 41% to 80% by December 2020. The secondary aim was to maintain timeliness in ‘High Performer’ sites.

Method
During the intervention phase (March–December 2020), plan-do-study-act (PDSA) cycles included webinars, facilitated exploratory conversations, data review and development of a best practice guide (‘Getting Started Toolkit’). On-boarded ‘New Centers’ starting in 2020 were also invited to test intervention effectiveness. Balancing measures included data collector job satisfaction and stress and resubmission rates.

Results
‘High Performer’ and ‘High Potential’ centers submitted 11 358 cases from November 2019 to December 2020. Timely submission rates for ‘High Potential’ centers improved from 40.6% to 74.6% and were maintained at &gt;90% for ‘High Performer’ centers. ‘New Centers’ averaged 92.6% timely case submissions during their first 6 months. Data collector job satisfaction and stress were not impacted, and the resubmission rates did not increase.

Conclusion
PAC3’s multicenter QI project increased data submission timeliness in a large pediatric subspecialty registry. The lessons learned and the Toolkit developed can be applied in other registries to improve data submission efficiency, with resultant improvement in benchmarking, QI, research, length of stay and outcomes.
The Potential of Meta-ethnography in the Study of Public Administration: A Worked Example on Social Security Encounters in Advanced Liberal Democracies
Authors: Boswell John , Smedley Stuart 
Published: October 2022

Abstract
The purpose of this article is to highlight meta-ethnography—the interpretive synthesis of ethnographic studies on a given theme—as a useful tool in the study of social policy and public administration. We claim this approach can maximize the impact of rich idiographic research to enable theory-refining and evidence-building efforts in the field. We illustrate these benefits through reference to a worked example focused on public encounters with social security in advanced liberal democracies. We show how we drew together 49 ethnographic studies from a variety of disciplines to identify repertoires of response that citizens exercise in their encounters with the contemporary welfare state. Through this analysis, we demonstrate how meta-ethnography can shed new light on topical contemporary debates about administrative burden. We conclude by reflecting on the prospects and limits of this technique for broader use in the field.
Successful functional salvage of a hindfoot injury with isolated soft tissue reconstruction: a case report
Authors: Alammar Alwaleed K , Alqumber Nedhal A , Alsahabi Abdulrahman , Almadani Jamal , Alsubhi Fatema , Alfaqeeh Faisal A 
Published: October 2022

Abstract
Calcaneus has an important functional role in walking, running, gait and transferring 80% of total weight. Due to the paramount role of the calcaneus in function, there is a trend toward ‘below knee amputation’ for such heel injuries, associated with complete loss of calcaneus. Complex calcaneal defects represent a reconstructive challenge, due to few reported cases in the literatures, limited surgical options, and lack of long-term outcomes. We present a young patient regaining near normal function, weight bearing and independent walking after sustaining complex hindfoot defect that resulted in total loss of the calcaneus secondary to a landmine blast injury managed by soft tissue reconstruction only without skeletal reconstruction.
Avoiding Pragmatic Oddity: a bottom-up Defeasible Deontic Logic
Authors: Governatori Guido , Colombo Tosatto Silvano , Rotolo Antonino 
Published: October 2022

Abstract
This paper presents an extension of Defeasible Deontic Logic to deal with the Pragmatic Oddity problem. The logic applies three general principles: (i) the Pragmatic Oddity problem must be solved within a general logical treatment of contrary-to-duty (CTD) reasoning; (ii) non-monotonic methods must be adopted to handle CTD reasoning; (iii) logical models of CTD reasoning must be computationally feasible and, if possible, efficient. The proposed extension of Defeasible Deontic Logic elaborates a preliminary version of the model proposed by Governatori and Rotolo [15]. The previous solution was based on particular characteristics of the (constructive, top-down) proof theory of the logic. However, that method introduces some degree of non-determinism. To avoid the problem, we provide a bottom-up characterization of the logic. The new characterization offers insights for the efficient implementation of the logic and allows us to establish the computational complexity of the problem.
A massive, energetic model for the luminous transitional Type Ib/IIb SN 2020cpg
Authors: Teffs J , Mazzali P A , Medler K , Hachinger S 
Published: October 2022

ABSTRACT
Using a combined spectral and light-curve modelling approach, we fit a massive and energetic explosion model to the luminous Type Ib/IIb SN 2020cpg. This model has an ejected mass of ∼(7 ± 2) M⊙ with a final explosion energy of ∼(6 ± 1) × 1051 erg with MNi = 0.27 ± 0.05 M⊙. The early spectra are hot and blue with weak He i lines, and a complicated Hα region suggested to be a multicomponent feature. Modelling the spectra required ∼0.08 M⊙ of H at velocities &gt;11 000 km s−1 and a total He mass of ∼1.0 M⊙ at velocities &gt;9500 km s−1 above CO-rich ejecta. This model has a ratio of kinetic energy and ejected mass of 0.85$_{-0.3}^{+0.5}$ foe M⊙−1. The high luminosity and explosion energy results in a broadened Hα line that is blended with Si ii, C ii, and He i, which led to the initial classification of SN 2020cpg as a Type Ib. We instead classify SN 2020cpg as a bright transitional event between the Type Ib and Type IIb classes. Comparing our model parameters to stellar evolution models, a progenitor mass of 25–30 M⊙, i.e. stripped of most of the hydrogen shell and of some of the helium shell prior to collapse produces a He core of comparable mass. The excess 56Ni production in SN 2020cpg as compared to objects of similar ejected mass may suggest evidence of additional energy sources such as a failed GRB or weak magnetar energy injection, or a smaller remnant mass.
Police relational accountabilities: The paralysis of police accountability?
Authors: Cooper Simon 
Published: October 2022

Abstract
This article examines the new relational accountabilities of Chief Constables, Police, and Crime Commissioners (PCCs) and Police and Crime Panels (PCPs) in England and Wales. Referring to a number of recent reports and reviews, the discussion initially focuses on the effectiveness of these relationships and, in particular, the inefficiency of PCPs. Using new empirical data obtained through interviews with senior stakeholders in policing at regional and national levels, and relevant persons in Government, this research shows PCPs are impotent and ineffective. This article develops current understanding, showing that PCPs may cause a new unforeseen consequence. Namely, the exercise of accountability and the governance of policing may be unusually reactive to the ‘one-to-one’ accountability relationship between PCCs and Chief Constables. This research is all the more important in light of Her Majesty’s Inspector of Constabulary and Fire & Rescue Services finding in 2022 that there is an ‘atmosphere of mistrust and fear’ between PCCs and Chief Constables and The Police Foundation reporting ‘a crisis of confidence’, recommending ‘root and branch reform’ (Her Majesty’s Inspectorate of Constabulary and Fire & Rescue Services 2022). Such recommendations are made to strengthen the exercise of accountability and the governance of policing. Specifically, the Home Secretary is encouraged to review the Policing Protocol Order (2011) and issue a Memorandum of Understanding to ensure ‘effective, constructive working relationships’ are not just a quixotic pursuit but a practical reality that safeguards the governance of policing.
Toward a modular evaluation approach of real-world laboratories: Findings from a literature review
Authors: Kampfmann Teresa , Bernert Philip , Lang Daniel J 
Published: October 2022

Abstract
The number of real-world laboratories (RwLs) as research settings to address sustainability problems by using collaborative and experimental approaches has been growing steadily over the past years. RwLs are widely considered promising settings for the production of action-orientated knowledge in order to contribute solving wicked real-world problems such as climate change. However, empirically tested evaluative approaches are rare. We argue that evaluations within RwLs are crucial for ensuring high-quality and impactful research, amplifying tested solution approaches, and driving innovative forms of transdisciplinary collaboration. At the same time, evaluations within RwLs seem difficult due to the multilayered structure of RwLs. In order to provide guidance regarding the evaluation in RwLs- for researchers and practitioners, we conduct a scoping literature review that encompasses a comprehensive understanding of RwLs. We identify studies in which the specific components of RwLs lab context, experiments, and interventions—are empirically evaluated. Drawing on our findings, we derive different types of approaches that can be used for evaluating RwLs in practice. Based on how labs, experiments, and interventions in real-world settings have been evaluated in practice so far, we suggest to design evaluation approaches depending on (1) what should exactly be evaluated in the specific RwL, (2) for which purpose, and (3) by whom. We hope this targeted, modular evaluation approach based on evaluation types found in literature will help actors engaged in RwLs to make evaluations more feasible and impactful.
Pathway profiles: Learning from five main approaches to assessing interdisciplinarity
Authors: Laursen Bethany K , Motzer Nicole , Anderson Kelly J 
Published: October 2022

Abstract
Monitoring and evaluating interdisciplinarity is crucial for informing decisions about interdisciplinary (ID) policies, funding, and work. Yet, the recent explosion of ID assessment approaches represents an overwhelming buffet of options that has produced little consensus, limited guidance, and minimal insights into interdisciplinarity and its value to society. This article extends findings from a companion study that systematically reviewed the ID assessment field from 2000 to 2019. Engaging with the same extensive dataset but in a new way, we employ typological analysis and condense 1,006 published assessment designs into just five main assessment approaches called Pathway Profiles. We then tailor assessment guidance to each Pathway Profile, including potential settings in which each could be most useful and ways each could be modified to reduce challenges and increase rigor. Our goal in defining and interacting with the core of the ID assessment field in this way is not only to clarify activity in this vast and disjointed space but also to simplify and facilitate processes of understanding, choosing from, and strategically developing this diverse landscape. Pathway Profiles can be used as heuristic gateways to the ID assessment field, particularly when it comes to finding relevant examples, adapting designs to situations, and ultimately uncovering the true outcomes of interdisciplinarity.
Social goals in girls transitioning to adolescence: associations with psychopathology and brain network connectivity
Authors: Pelletier-Baldelli Andrea , Sheridan Margaret A , Glier Sarah , Rodriguez-Thompson Anais , Gates Kathleen M , Martin Sophia , Dichter Gabriel S , Patel Kinjal K , Bonar Adrienne S , Giletta Matteo , Hastings Paul D , Nock Matthew K , Slavich George M , Rudolph Karen D , Prinstein Mitchell J , Miller Adam Bryant 
Published: October 2022

AbstractThe motivation to socially connect with peers increases during adolescence in parallel with changes in neurodevelopment. These changes in social motivation create opportunities for experiences that can impact risk for psychopathology, but the specific motivational presentations that confer greater psychopathology risk are not fully understood. To address this issue, we used a latent profile analysis to identify the multidimensional presentations of self-reported social goals in a sample of 220 girls (9–15 years old, M = 11.81, SD = 1.81) that was enriched for internalizing symptoms, and tested the association between social goal profiles and psychopathology. Associations between social goals and brain network connectivity were also examined in a subsample of 138 youth. Preregistered analyses revealed four unique profiles of social goal presentations in these girls. Greater psychopathology was associated with heightened social goals such that higher clinical symptoms were related to a greater desire to attain social competence, avoid negative feedback and gain positive feedback from peers. The profiles endorsing these excessive social goals were characterized by denser connections among social-affective and cognitive control brain regions. These findings thus provide preliminary support for adolescent-onset changes in motivating factors supporting social engagement that may contribute to risk for psychopathology in vulnerable girls.
Visceral leishmaniasis in the COVID-19 pandemic era
Authors: Paul Anindita , Singh Sushma 
Published: October 2022

Abstract
Visceral l eishmaniasis (VL), also known as kala-azar, had once been targeted for elimination in 2020, which now has been shifted to 2030. The year 2020 was also the year in which the world was gripped by the coronavirus disease 2019 (COVID-19) pandemic. This review sheds light on the impact of COVID-19 on VL elimination programmes and the increasing incidences of COVID-19/VL cases. Lockdowns were imposed worldwide that led to the suspension of surveys, active case finding and mass drug administration, which are important activities to manage neglected tropical diseases. Healthcare machinery was redirected to control the pandemic and acute resource shortages were seen. Budget cuts from funding agencies and donors also came as a severe blow. Priority changes for manufacturers of drugs and diagnostic kits have also exacerbated the situation. Cases where patients were co-infected with VL and COVID-19 were reported across various settings and in people of various age groups, posing unprecedented challenges in diagnosis and treatment. Concerted efforts from all stakeholders are required to understand and deal with the impact that this pandemic has had on VL.
Nonsurgical treatment options for basal cell carcinoma
Authors: Rao Himanshu , Cartron Alexander , Khachemoune Amor 
Published: October 2022

ABSTRACT
Basal cell carcinoma (BCC) is the most common form of nonmelanoma skin cancer. Surgery, including Mohs micrographic surgery, is considered the gold standard for the management of BCC, yet some patients may be unable to undergo surgery. This article describes effective nonsurgical options for treating superficial BCCs as well as some nodular and infiltrative BCCs.
Nailfold video-capillaroscopy in the study of cardiovascular disease: a systematic review
Authors: Lim Matthew W.S. , Setjiadi Dellaneira , Dobbin Stephen J.H. , Lang Ninian N. , Delles Christian , Connelly Paul J. 
Published: October 2022

Objectives
Nailfold video-capillaroscopy (NVC) is an inexpensive method of assessing microcirculation. We reviewed the literature to assess whether changes to the nailfold capillaries exist in patients with cardiovascular disease (CVD).

Methods
We searched PubMed, Scopus and Cochrane Library databases for original research articles relating to the use of noninvasive microvascular assessment in patients with CVD. Methodological quality was assessed with the ‘Quality Assessment Tool for Observational Cohort and Cross-sectional Studies.’ The results obtained from NVC were analysed qualitatively and compared with other forms of microvascular assessment.

Results
In total 2759 articles were screened, of which 22 studies involving 562 patients (~40% women) with CVD were included. Mean age ranged between 3.7–68.4 years (cases) and 4.0–58.0 years (controls). Reduced capillary density and increased capillary dimensions were seen in patients with pulmonary arterial hypertension (PAH). Among patients with systemic sclerosis, advanced scleroderma patterns can be used to identify patients with or at risk of developing PAH. Functional nailfold changes precede structural changes in patients with hypertension. However, the studies were heterogeneous in the diagnosis of disease and the measurement of nailfold parameters. Most studies did not exclude conditions with altered nailfold features, and only one study performed a power calculation. Furthermore, abnormal nailfold findings are present in patients without systemic disease.

Conclusions
Structural and functional changes to the nailfold are a feature of established CVD and precede the development of PAH. However, heterogeneity in measurement and abnormal findings in healthy participants limit their use in the wider population.