bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kidney–Urinary Tract Involvement in Intermediate Junctional Epidermolysis Bullosa
Authors: Trefzer Laura , Schwieger-Briel Agnes , Nyström Alexander , Conradt Gregor , Pohl Martin , Miernik Arkadiusz , Has Cristina 
Published: August 2022

ImportanceKidney–urinary tract (KUT) manifestations cause substantial morbidity in patients with junctional epidermolysis bullosa (JEB), but the spectrum of disease severity and the clinical course have been poorly characterized.ObjectiveTo examine in a large cohort of patients with intermediate JEB the KUT manifestations, diagnostic and therapeutic procedures, genotype-phenotype correlations, and outcomes as a basis for recommendations, prognosis, and management.Design, Setting, and ParticipantsIn this retrospective, longitudinal case series study, 99 patients with a diagnosis of JEB based on clinical and genetic findings who were treated in a single dermatology department in Freiburg, Germany, were assessed during an 18-year period (January 1, 2003, to December 31, 2021). Clinical, laboratory, and molecular genetic parameters were extracted from patients’ medical records.Main Outcomes and MeasuresClinical characteristics, natural history, management of KUT manifestations, and genotype-phenotype correlations of intermediate JEB.ResultsOf the 183 patients with JEB, 99 (54%) had intermediate JEB and were included in this cohort. The cohort included 49 female patients and 50 male patients. None of 49 female patients and 15 of 50 male patients had KUT involvement affecting different levels of the urinary tract, resulting in a prevalence of 30% for males; thus, the overall prevalence was 15%. The mean age at onset of KUT manifestations was 6.9 years (range, first weeks of life to 20 years; age was not available for 1 patient). Median follow-up after diagnosis of KUT involvement was 13 years (range, 3 months to 54 years). Patients with laminin 332 or integrin β4 deficiency had at least 1 missense or splice site genetic variant, leading to residual expression of laminin 332 or integrin α6β4, respectively. Severity of KUT complications did not correlate with the extent of skin involvement but with the affected protein.Conclusions and RelevancePhysicians and patients with JEB should be aware of the risk for KUT involvement in intermediate JEB, and physicians should apply interdisciplinary and individualized diagnostic and therapeutic procedures for management of these complications. Because this disorder is so rare, multicenter studies are required to make general recommendations.
Patient‐Reported Outcomes Among Patients Ages Two to Seventeen Years With Polyarticular‐Course Juvenile Idiopathic Arthritis Treated With Subcutaneous Abatacept: Two‐Year Results From an International Phase III Study
Authors: Ruperto Nicolino , Lovell Daniel J. , Berman Alberto , Ávila‐Zapata Francisco , Horneff Gerd , Alessio Maria , Becker Mara L. , Belot Alexandre , Burgos‐Vargas Ruben , Gamir Maria L. , Goldenstein‐Schainberg Claudia , Scheibel Iloite M. , Terreri Maria T. , Zemel Lawrence , Zhuo Joe , Askelson Margarita , Wong Robert , Martini Alberto , Brunner Hermine I. ,   for the Pediatric Rheumatology Collaborative Study Group and the Paediatric Rheumatology International Trials Organisation
Published: August 2022

ObjectiveTo describe longitudinal changes in patient‐reported outcomes (PROs) in children with polyarticular‐course juvenile idiopathic arthritis (pJIA) treated with subcutaneous abatacept.MethodsSecondary analysis of a single‐arm, open‐label 24‐month study of patients ages 6–17 years and 2–5 years. PROs included Childhood Health Assessment Questionnaire‐Disability Index (CHAQ‐DI), parent global assessment of child well‐being (PaGA), pain assessment, and Activity Limitation Questionnaire (ALQ). Clinical outcomes included 50% or greater improvement in JIA American College of Rheumatology (ACR) criteria, clinically inactive disease, and Juvenile Arthritis Disease Activity Score.ResultsFor the 6‐ to 17‐year‐old (n = 173) and 2‐ to 5‐year‐old (n = 46) cohorts, respectively, median (Q1, Q3) changes from baseline in CHAQ‐DI at months 4 and 24 were −0.3 (−0.8, 0.0) and −0.5 (−1.0, −0.1), and −0.4 (−0.8, 0.0) and −0.5 (−1.0–−0.1). Median pain scores were below cutoff threshold for clinically relevant pain (<35 mm) by month 1 (6 to 17 years, 32.3 mm; 2 to 5 years, 25.7 mm), reaching a nadir at month 24 (6 to 17 years, 6.0 mm; 2 to 5 years, 2.0 mm). For the 6‐ to 17‐year‐old and 2‐ to 5‐year‐old cohorts, respectively, median PaGA scores were 47.8 (n = 172) and 42.1 (n = 46) at baseline and 6.3 (n = 107) and 2.0 (n = 37) at month 24. In both cohorts, ALQ components improved from baseline to month 4 and were largely maintained to month 24. Clinical outcomes improved through to month 24.ConclusionEarly and sustained PRO improvements were reported in this phase III, open‐label trial of subcutaneous abatacept in patients with pJIA.
Visible‐Light‐Degradable 3D Microstructures in Aqueous Environments
Authors: Gernhardt Marvin , Truong Vinh X. , Barner‐Kowollik Christopher 
Published: August 2022

AbstractThe additive manufacturing technique direct laser writing (DLW), also known as two‐photon laser lithography, is becoming increasingly established as a technique capable of fabricating functional 3D microstructures. Recently, there has been an increasing effort to impart microstructures fabricated using DLW with advanced functionalities by introducing responsive chemical entities into the underpinning photoresists. Herein, a novel photoresist based on the photochemistry of the bimane group is introduced that can be degraded upon exposure to very mild conditions, requiring only water and visible light (λmax = 415–435 nm) irradiation. The degradation of the microstructures is tracked and quantified using AFM measurements of their height. The influence of the writing parameters as well as the degradation conditions is investigated, unambiguously evidencing effective visible light degradation in aqueous environments. Finally, the utility of the photodegradable resist system is demonstrated by incorporating it into multimaterial 3D microstructures, serving as a model for future applications.
Energy Interplay in Materials: Unlocking Next‐Generation Synchronous Multisource Energy Conversion with Layered 2D Crystals
Authors: Corletto Alexander , Ellis Amanda V. , Shepelin Nick A. , Fronzi Marco , Winkler David A. , Shapter Joseph G. , Sherrell Peter C. 
Published: August 2022

AbstractLayered 2D crystals have unique properties and rich chemical and electronic diversity, with over 6000 2D crystals known and, in principle, millions of different stacked hybrid 2D crystals accessible. This diversity provides unique combinations of properties that can profoundly affect the future of energy conversion and harvesting devices. Notably, this includes catalysts, photovoltaics, superconductors, solar‐fuel generators, and piezoelectric devices that will receive broad commercial uptake in the near future. However, the unique properties of layered 2D crystals are not limited to individual applications and they can achieve exceptional performance in multiple energy conversion applications synchronously. This synchronous multisource energy conversion (SMEC) has yet to be fully realized but offers a real game‐changer in how devices will be produced and utilized in the future. This perspective highlights the energy interplay in materials and its impact on energy conversion, how SMEC devices can be realized, particularly through layered 2D crystals, and provides a vision of the future of effective environmental energy harvesting devices with layered 2D crystals.
Stability of Perovskite Light‐Emitting Diodes: Existing Issues and Mitigation Strategies Related to Both Material and Device Aspects
Authors: Kong Lingmei , Zhang Xiaoyu , Zhang Chengxi , Wang Lin , Wang Sheng , Cao Fan , Zhao Dewei , Rogach Andrey L. , Yang Xuyong 
Published: August 2022

AbstractMetal halide perovskites combine excellent electronic and optical properties, such as defect tolerance and high photoluminescence efficiency, with the benefits of low‐cost, large‐area, solution‐based processing. Composition‐ and dimension‐tunable properties of perovskites have already been utilized in bright and efficient light‐emitting diodes (LEDs). At the same time, there are still great challenges ahead to achieving operational and spectral stability of these devices. In this review, the origins of instability of perovskite materials, and reasons for their degradation in LEDs are considered. Then, strategies for improving the stability of perovskite materials are reviewed, such as compositional engineering, dimensionality control, defect passivation, suitable encapsulation matrices, and fabrication of core/shell perovskite nanocrystals. For improvement of the operational stability of perovskite LEDs, the use of inorganic charge‐transport layers, optimization of charge balance, and proper thermal management are considered. The review is concluded with a detailed account of the current challenges and a perspective on the key approaches and opportunities on how to reach the goal of stable, bright, and efficient perovskite LEDs.
Transparent Thiol‐ene/Acrylate‐Based MicroECoG Devices Used for Concurrent Recording of Fluorescent Calcium Signals and Electrophysiology in Awake Animals
Authors: Szabó Ágnes , Madarász Miklós , Lantos Zsófia , Zátonyi Anita , Danda Vindhya , Spurgin Lisa , Manz Connie , Rózsa Balázs , Fekete Zoltán 
Published: August 2022

AbstractShape memory polymers (SMPs) are suitable substrate materials for soft neural interfaces due to their tunable elastic characteristics. The stability and biocompatibility of intracortical SMP probes are demonstrated. In this work, a SMP‐based cortical implant capable of recording high‐density micro‐electrocorticography is utilized in a multimodal neuroimaging scheme. The transparent nature of thiol‐ene/acrylate substrate is exploited, and the feasibility of measuring intracranial electroencephalogram and fluorescent GCaMP6 signals with two‐photon imaging through the device is presented in mice. The potential influence of the optical properties of the microdevice is investigated using fluorescent microbeads, hippocampal brain slices, and awake animals. It is found that neurites and cell soma can be efficiently detected with sufficient resolution to follow changes in the calcium signal. These chronically implanted devices do not suppress the quality of optical signals exceeding 22 weeks after implantation. These results indicate that thiol‐ene/acrylate ECoG is an appropriate tool to combine electrophysiology with two‐photon imaging while leveraging the inherent tissue‐friendly properties of SMPs.
Cell Membrane Mimetic Coating for Excellent Antifouling, Antibacterial Corrosion, and Self‐Cleaning Separation of Massive Oil–Water Mixtures
Authors: Meng Fan‐Ning , Li Rong , Yao Yao , Qiao Xin‐Yu , Gong Yong‐Kuan 
Published: August 2022

AbstractMassive oil–water mixtures produced from both industries and frequent oil spill incidents have threatened water ecosystems. A highly efficient separation membrane with ultrahigh filtration flux and excellent antifouling performance is created to deal with oil–water mixtures. The filtration membrane is fabricated by anchoring a phosphorylcholine copolymer (PMEN) on polydopamine (PDA)‐precoated stainless steel mesh (SSM) surfaces, forming a durable cell outer membrane mimetic coating. The as‐prepared SSM/PDA/PMEN membranes exhibit superhydrophilicity and high separation efficiency (≥99.98%) for different oil–water mixtures. Furthermore, the water flux of separating 30 v/v% crude oil–water mixture can reach as high as 70 000 L m–2 h–1 and remains higher than 30 000 L m–2 h–1 without any additional washing during 100 cycles of successive separations in a dead‐end filtration device. More importantly, substantial corrosion of stainless steel surfaces by bacteria is prevented on the cell membrane mimetic coating by its excellent antibacterial adhesion performance. These unprecedented underwater anticrude oil‐fouling and antibacterial‐corrosion properties, as well as the ultrahigh flux and high separation efficiency of SSM/PDA/PMEN membranes, are highly promising in the cleanup of massive oily water and oil spills in the near future.
Base‐Catalyzed Domino Reaction Between Aldoxime and N‐Chlorosuccinimide in Alcohol: One‐Pot Synthesis of Alkyl 3‐(3‐Aryl‐1,2,4‐oxadiazol‐5‐yl)propanoates
Authors: Chilaka Sai Krishna , Chellu Ramesh Kumar , Soda Anil Kumar , Kurva Srinivas , Nanubolu Jagadeesh Babu , Madabhushi Sridhar 
Published: August 2022

AbstractA method for preparation of alkyl 3‐aryl‐(1,2,4‐oxadiazol‐5‐yl)propanoates by base‐catalyzed domino reaction of an aryl aldoxime with N‐chlorosuccinimide in alcohol is described. In this reaction, initially aldoxime and N‐chlorosuccinimide react to produce hydroximidoyl chloride and succinimide. The hydroximidoyl chloride and base produces nitrile oxide which undergoes [3+2] annulation with succinimide followed by ring opening reaction with the assistance of alcohol to give alkyl 3‐aryl‐(1,2,4‐oxadiazol‐5‐yl)propanoates in 65–95% yield.magnified image
Iron‐Catalyzed Reductive Cyclization of Alkenyl Vinylogous Carbonates for Stereoselective Synthesis of Substituted Tetrahydrofurans, Tetrahydropyrans, and Chromans
Authors: Gharpure Santosh J. , Chavan Rupali S. , Ardhapure Ajaykumar V. 
Published: August 2022

AbstractA method for the stereoselective synthesis of substituted tetrahydrofurans (THFs), tetrahydropyrans (THPs), as well as chromans using intermolecular hydrogen atom transfer (HAT) followed by intramolecular radical cyclization of alkenyl vinylogous carbonates is described. This Fe(acac)3‐catalyzed reaction uses PhSiH3 as H‐source and works under ambient conditions in HFIP/ethylene glycol (5:1 mixture) as solvent. The methodology developed has broad substrate scope and is amenable to gram‐scale synthesis. The method gives ready access to even hexa‐substituted cyclic ethers containing two quaternary carbons. This strategy is used in the construction of oxaspirocyclic systems. Diastereoselective synthesis of fused bicyclic as well as tricyclic motifs could be achieved. The stereochemistry of the products was assigned using NOE experiments and was further confirmed by single‐crystal X‐ray diffraction studies on two derivatives.magnified image
Cation‐Diffusion‐Based Simultaneous Bulk and Surface Passivations for High Bandgap Inverted Perovskite Solar Cell Producing Record Fill Factor and Efficiency
Authors: Mahmud Md Arafat , Zheng Jianghui , Tang Shi , Wang Guoliang , Bing Jueming , Bui Anh Dinh , Qu Jiangtao , Yang Limei , Liao Chwenhaw , Chen Hongjun , Bremner Stephen P. , Nguyen Hieu T. , Cairney Julie , Ho‐Baillie Anita W. Y. 
Published: August 2022

AbstractHigh bandgap perovskite solar cells are integral to perovskite‐based multi‐junction tandem solar cells with efficiency potentials over 40%. However, at present, high bandgap perovskite devices underperform compared to their mid bandgap counterparts in terms of voltage outputs and fill factors resulting in lower than ideal efficiencies. Here, the low fill factor aspect of high bandgap perovskite is addressed by developing a cation‐diffusion‐based double‐sided interface passivation scheme that simultaneously provides bulk passivation for a 1.75 eV perovskite cell that is also compatible with a p‐i‐n cell architecture. The champion cell achieves a record fill factor of 86.5% and a power conversion efficiency of 20.2%. Results of ionic distribution profiling, Fourier transform infrared spectroscopy, and X‐ray diffraction crystallography reveal evidence of cation diffusion from the surface perovskite passivation layer into bulk. The diffused cations reduce Shockley–Read–Hall recombination in the perovskite bulk and at the surfaces with the latter being more dominant as confirmed by light‐intensity dependent and temperature‐dependent open‐circuit voltage measurements as well as thermal admittance spectroscopy. This concurrent bulk and surface passivation scheme renders record fill factor and efficiency in the double‐side passivated cells. This provides new insights for future passivation strategies based on ionic diffusion of functionalized materials.
Phylogenetic and functional signal in prezygapophyseal articular facet shape of the first post‐transitional vertebra in anthropoids
Authors: Jung Hyunwoo , Simons Evan A. , Holowka Nicholas B. , von Cramon‐Taubadel Noreen 
Published: August 2022

AbstractObjectivesPrevious studies of the prezygapophyseal articular facet (PAF) of the thoracolumbar vertebrae in primates have suggested that the morphology of this feature reflects relative mobility of the lower back, and therefore corresponds to locomotor behavior. Specifically, these studies suggest that the PAF morphology found in cercopithecoids reflects greater mobility of the lower back compared to a stiffer lower back adapted for forelimb‐dominated suspensory behaviors in hominoids. In this study, we sought to re‐examine this question in terms of both locomotor behavior and phylogenetic signal in a broad sample of anthropoid taxa.Materials and MethodsThe study sample consisted of 291 first post‐transitional vertebrae of wild‐caught individuals representing 27 extant anthropoid species (16 genera). Vertebrae were 3D scanned, and 19 landmarks were digitized. PAF shape was tested for the presence of a phylogenetic signal using the multivariate version of the K‐statistic (Kmult), and a chronometric consensus phylogenetic tree was mapped onto the major axes of shape space using species means to produce a phylomorphospace.ResultsResults showed that phylogenetic signal is statistically significant in PAF shape (Kmult = 0.3; p < 0.0001), and phylogenetic separation is apparent in the phylomorphospace, with some exceptions. However, certain aspects of PAF shape also appear to be associated with locomotor behavior within major taxonomic groups, such as hominoids and platyrrhines.DiscussionOur results suggest that both phylogenetic relatedness and function may contribute to PAF shape variation in anthropoids.
Survival, safety and belonging: An ethnographic study of experiences and perceptions of people who inject drugs accessing a supervised injecting Centre
Authors: Rickard Greg , Hart Bethne 
Published: August 2022

AbstractIntroductionThe inclusion of people who use drugs in the design and evaluation of their health services remains a relatively new phenomenon. The aim of the research was to explore the experiences and perceptions of people accessing the Medical Supervised Injecting Centre (MSIC), and Clinic 180, Sydney Australia, and the factors facilitating and inhibiting their participation. The research was undertaken within a framework of critical ethnography.MethodsTwenty‐three participants who inject drugs at the MSIC and five from Clinic 180 who chose not to use the MSIC were interviewed using semi‐structured interviews to hear and raise their experiences and perceptions of these services within their everyday lives.ResultsPeople who accessed the MSIC narrated a sense of personhood, survivor‐hood, community and belonging. The overarching emerging theme was “I’m Human.” People who accessed The Clinic services spoke of the MSIC as reinforcing the stigmatisation of the “users” and increasing the temptation to continue to inject drugs.DiscussionThis research gathered the experiences and perceptions of people accessing MSIC and Clinic 180. This can inform and reinforce public health and harm reduction approaches that embrace trauma informed care and social justice actions. This research also demonstrates the alignment between critical ethnography and the emerging models of co‐design, co‐production and health partnerships, sharing the shifting of power relations.ConclusionThe experiences and perceptions of people who inject drugs, and an understanding of their everyday lives, are essential to the design and evaluation of the services they access.
A 10‐year retrospective cohort study of non‐tubal ectopic pregnancy management outcomes in an Australian tertiary centre
Authors: Loh Wei‐Guo Nicholas , Adno Alan Maurice , Reid Shannon 
Published: August 2022

AbstractIntroductionNon‐tubal ectopic pregnancy (NTEP) is a rare but significant early pregnancy complication which can result in maternal morbidity and mortality. There is however a lack of evidence‐based guidelines for the management of NTEP.PurposeTo evaluate the success rates of expectant, medical and surgical management in the treatment of NTEP at our tertiary centre.MethodsRetrospective cohort study from 2010 to 2020. All NTEP were classified by ectopic sites. Primary management was classified by expectant, medical [systemic methotrexate (Sys‐MTX) and/or local ultrasound‐guided injection of MTX and/or KCl intra‐sac (L‐MTX, L‐MTX/KCl)] or surgical. Primary management was considered successful if no change in intervention was required. Treatment complications were compared.ResultsTwenty‐four NTEP were identified, which included 14 interstitial pregnancies (IP), 9 caesarean scar pregnancies (CSP) and 1 ovarian pregnancy (OP), which gave NTEP an incidence of 7.12% among all EP (4.15% for IP, 2.67% for CSP and 0.30% for OP). The success of primary surgical management was 100% (7/7), primary medical management was 76.9% (10/13) and primary expectant management was 33.3% (1/3). Primary medical management had a non‐statistically significant greater mean time to serum ß‐human Chorionic Gonadotrophin <5 IU/L, mean length of hospitalisation, mean number of follow‐up visits and hospital re‐presentation/readmissions compared to primary surgical management. There was no other difference in complication rates between the treatment management groups.ConclusionSurgery remains the most effective way to manage NTEP. However, medical management can be a safe and effective alternative option in carefully selected cases.
A review: Systematic research approach on toxicity model of liver and kidney in laboratory animals
Authors: Abbasnezhad Abbasali , Salami Fatemeh , Mohebbati Reza 
Published: August 2022

AbstractTherapeutic experiments are commonly performed on laboratory animals to investigate the possible mechanism(s) of action of toxic agents as well as drugs or substances under consideration. The use of toxins in laboratory animal models, including rats, is intended to cause toxicity. This study aimed to investigate different models of hepatotoxicity and nephrotoxicity in laboratory animals to help researchers advance their research goals. The current narrative review used databases such as Medline, Web of Science, Scopus, and Embase and appropriate keywords until June 2021. Nephrotoxicity and hepatotoxicity models derived from some toxic agents such as cisplatin, acetaminophen, doxorubicin, some anticancer drugs, and other materials through various signaling pathways are investigated. To understand the models of renal or hepatotoxicity in laboratory animals, we have provided a list of toxic agents and their toxicity procedures in this review.