bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of Surgical Apgar Score for clinical outcomes and complications in the patients treated with single- level posterior lumbar interbody fusion
Authors: Shinohara Kensuke , Yokoo Suguru , Yamane Kentaro , Takao Shinichiro , Nakahara Shinnosuke , Takeuchi Kazuhiro 
Published: November 2022

Abstract
Background.
The Surgical Apgar Score (SAS) has effectively prognosticated major complications in several surgeries including spine surgery. However, whether SAS can predict complications and patient reported outcomes after posterior lumbar interbody fusion (PLIF) has not been evaluated. The aim of this study was to analyze the relationship between SAS and clinical outcomes after PLIF.
Methods.
This research was retrospective clinical study. All patients who underwent a PLIF with singe-level, planned surgery from 2010 to 2022 were enrolled. Multilevel, revision, and unplanned PLIFs were excluded. Operative notes and anesthesia records were reviewed for estimated blood loss, lowest mean arterial pressure, and lowest heart rate. Japanese Orthopaedic Association (JOA) lumbar score and JOA improvement rate were recorded. Patients were divided into four groups by SAS (0–4, 5–6, 7–8, 9–10) and associated complications in each group were reviewed. A correlation coefficient between SAS and JOA improvement rate was also calculated. The receiver operating characteristic (ROC) analysis was used to evaluate the discriminatory power of SAS.
Results.
A total of 815 patients met study criteria. Major complications were reported for 33 patients. The incident rate of complications was 53.8% with SAS 0–4, 7% with SAS 5–6, 2.6% with SAS 7–8 and 0% with SAS 9–10, respectively. There were no reported deaths. Peripheral vascular disease (p = 0.01), moderate or severe renal disease (p = < 0.0001), diabetes with end organ damage (p = 0.01) and lymphoma (p = 0.02) were significantly more common in patients with major complications. The SAS and complications ROC reported an area under the curve of 0.73. The correlation coefficient between SAS and JOA improvement rate was weakly positive (r = 0.25).
Conclusion.
The data on this study shows SAS demonstrates good discriminatory power to predict post-operative complications. The relationship between SAS and JOA improvement rate is weakly positive.
Causal relationships between DNA methylation、Golgi membrane proteins、endoplasmic reticulum aminopeptidase and abnormal spermatozoa: a two sample Mendelian randomization study
Authors: Pang Lei , Ding Zijun , Chai Hongqiang , Li Fei , Wu Ming , Shuang Weibing 
Published: November 2022

Abstract
To explore the causal relationship between DNA methylation, Golgi membrane protein, endoplasmic reticulum aminopeptidase, ADP-ribose pyrophosphatase, mitochondrialon abnormal spermatozoa by two-sample Mendelian randomization (TSMR) method.Genetic loci closely related to DNA methylation PhenoAge acceleration, Golgi membrane protein 1, endoplasmic reticulum aminopeptidase 1, endoplasmic reticulum aminopeptidase 2, ADP-ribose pyrophosphatase, mitochondrial were selected as instrumental variables, andTSMR was performed by the inverse variance weighted method, MREgger regression, and weighted median method respectively. Sensitivity analysis was conducted to evaluate the robustness of the MR results.IVW showed that the DNA methylation PhenoAge acceleration(OR = 1.12, 95% CI: 1.01–1.23), Golgi membrane protein 1(OR = 1.22, 95% CI: 1.04–1.44), and endoplasmic reticulum aminopeptidase 2(OR = 1.13, 95% CI: 1.04–1.24) were associated with an increased risk of abnormal spermatozoa. However, there was no evidence of the association between ADP-ribose pyrophosphatase, mitochondrial (IVW OR = 1.25, 95% CI: 0.95–1.63), endoplasmic reticulum aminopeptidase 1 (IVW OR = 1.01, 95% CI: 0.90–1.12) and abnormal spermatozoa. Sensitivity analysis detected little evidence of pleiotropy in the current study.There is a positive causal relationship between DNA methylation PhenoAge acceleration, Golgi membrane protein 1, and endoplasmic reticulum aminopeptidase 2 on abnormal spermatozoa.
The therapeutic effect of larval saliva and hemolymph of Lucilia sericata on the treatment of Leishmania major lesion in BALB/c mice
Authors: Rahimi Sara , Rafinejad Javad , Akhavan Amir Ahmad , Ahmadkhaniha Reza , Bakhtiyari Mahmood , khamesipour Ali , Akbarzadeh Kamran 
Published: November 2022

Abstract
Background
Treatment of Cutaneous Leishmaniasis (CL) remains a major challenge for the public health and medical community. Natural compounds such as larval products of Lucilia sericata flies have Leishmanicidal effects against some species of Leishmania. The present study aimed at assessing the in vitro effects larval products against the promastigote and intracellular amastigote forms of Leishmania major. Also, the therapeutic effect of larval products on lesions induced by L. major infection was evaluated in BALB/c mice models.
Methods
The parasites and cells were treated with concentration of larval products ranging from 75-750ug/mL for 24-120h. Lesion progression and parasite load were investigated in the models for assessing the therapeutic effects of the products.
Results
The larval saliva and hemolymph showed highly cytotoxic effect against L. major promastigotes with IC50 values of 100.6 and 37.96ug/mL, respectively compared to Glucantime with 9.480ug/mL. Also, the results indicated that the larval products of L. sericata had greater cytotoxic effects on the promastigotes of L. major than on the macrophage cells (P < 0.05). Treatment with larval products decreased the infection rate and the number of amastigotes per host cell at all concentrations. The in vivo results showed a significantly (p < 0.0001) smaller lesion size in the groups of treated mice compared with the untreated control group. The average parasite burden groups of treated mice (1.81 ± 0.74, 1.03 ± 0.45 and 3.37 ± 0.41) were significantly lower (p = 0.0001) than untreated control group (6.72 ± 2.37), and was similar to the group treated with daily injection of Glucantime (1.77 ± 0.99).
Conclusion
The results suggested that L. sericata larval products are effective L. major in vivo and in vitro. However, more clinical trial studies are recommended to appraise the effects of these larval products in human subjects.
Fast Long-Term Tracking via Probabilistic Regression and Target Center Regression
Authors: Han Yongbo , Liang Yitao , Li Lei 
Published: November 2022

Abstract
The difficulty of long-term tracking mainly lies in the tracking failure caused by out-of-view, occlusion, and intra-class distractors. To deal with these difficulties, existing methods divide the tracking process into two parts, local tracking and global re-detection, and focus on designing robust distractor awareness mechanisms and global re-detection strategies. However, most state-of-the-art long-term trackers ignore the efficient design of the model and therefore may either be inefficiency or time-consuming. In this work, a real-time Long-term Tracking framework based on a local-global switching strategy is proposed, which utilizes Probabilistic regression and Target center regression to accelerate the long-term tracking process (named LTPT). To achieve reliable interaction between the local tracker and the global re-detector, LTPT introduces a probabilistic perspective to interpret the output of the local tracker. Additionally, this probabilistic regression approach benefits from the complementary use of attention mechanisms and deep cross-correlation to emphasize multiple hypotheses in the search region. To achieve fast re-detection, LTPT uses a rough target center regression to obtain a search region that may contain the target, and then refines the target position through a local tracker. Experiments on several datasets demonstrate that the method achieves comparable performance to the state-of-the-art algorithms.
Recurrence rates following ileo-colic resection in pediatric patients with Crohn’s disease
Authors: Dreznik Yael , Samuk Inbal , Shouval Dror S. , Paran Maya , Matar Manar , Shamir Raanan , Totah Moussa , Kravarusic Dragan 
Published: November 2022

Abstract
Background: Ileo-colic resection (ICR) is an important therapeutic option for Crohn’s disease (CD) patients. There is limited updated data of clinical and endoscopic post-operative recurrence (POR) in pediatric patients with CD for the long run. We aimed to determine recurrence rates following ICR over an extended period of time and asses its risk factors.
Methods: This is a single-center retrospective review of 35 patients with CD between the ages of 6 to 17.9 years who required ICR between 2003 and 2021at Schneider Children Medical Center of Israel. Medical charts were reviewed at different time-points post-ICR.
Results:
Clinical recurrence following ICR was demonstrated in only 11.4% and 28.6% (n=4, n=10) in the first two and five years- much lower rates than what was reported so far. We found no specific risk factor that correlated with clinical recurrence, although patients that were treated with early prophylaxis of anti TNF medications following ICR tend to have less recurrence.
Conclusions:
We found lower POR following ICR, especially in the first years after surgery- which can be attributed to close surveillance and early medical treatment. Such surveillance seem to improve recurrence rates in the first years following ICR.
Cryogenic Treatment to tailor the Interface of Impact Modified PET/PBT Blends
Authors: Pande Kavita , Chopra Swamini , Deshmukh Abhay , Kumar Anupama , Peshwe Dilip 
Published: November 2022

Abstract
Cryogenic treatment of polymers is a well-known area of research these days. Many reports confirm the fact that similar to metals, polymeric materials also undergo some structural changes which ultimately enhances mechanical properties like wear performance, tensile strength, impact strength, elongation, hardness, etc. The cryogenic treatment has proven an advantage for improving the properties of both virgin polymers and polymer micro-/nano-composites. The present study, first of its kind, reports the effect of cryogenic treatment on polymeric blends. An attempt is made to explore the effect of the treatment parameters, like temperature and time, on impact modified and unmodified PET/PBT blends. Similar to the polymers and composites, the blend systems studied here reflect significant improvement by ~ 50% in wear performance, ~ 16–19% in tensile strength and ~ 9% in impact strength after cryogenic treatment. Thus, after extensive analysis of the material properties, structure and thermal behavior, cryogenic treatment of PET/PBT blends, both impact modified and unmodified, is advocated as an effective tool for improving the performance.
CAPTAIN JOHN SMITH IN HUNGARY AND TRANSYLVANIA
Authors: Серегина А.Ю. 
Published: November 2022

Английский путешественник Джон Смит прославился как основатель первого английского поселения в Новом Свете и исследователь Америки. Однако большую часть жизни он провел в Старом Свете. Предлагаемая читателю публикация представляет комментированный русский перевод глав 1–17 автобиографического памфлета Джона Смита, посвященного его юности (1593–1604). В то время Смит был солдатом и воевал во Франции, Нидерландах, Венгрии и Трансильвании. Центральную часть его повествования занимают события Долгой войны Габсбургов с Османской империей. В статье показано, что венгерские события стали основой представления Смита о себе как о христианском рыцаре, достойном дворянского звания.
The name of John Smith, an English traveler and pamphleteer, is usually associated with the propaganda of European exploration of the New World. However, his reputation of a soldier and a man of the world was based on his fighting in European military campaigns, and especially — those that took part in Hungary and Transylvania in the course of the Long Turkish War (1593–1606). In his autobiographical pamphlet, extracts from which are published in Russian translation here, John Smith focused the major part of the text on a relatively short period (1600–1603) that he spent in Central and Eastern Europe. It will be argued that his Hungarian experience provided a basis for Smith’s self-image of a Christian soldier worthy of noble status.
Pengaruh Latar Belakang Pendidikan terhadap Kompetensi Pedagogik Guru Taman Kanak-kanak di Kabupaten Bengkalis
Authors: Selian Nurhaida , Khodijah Siti 
Published: November 2022

Penelitian ini bertujuan untuk mengetahui pengaruh latarbelakang pendidikan terhadap kompetensi pedagogik guru di TK gugus 3 kenanga kecamatan bantan kabupaten bengkalis. Hasil penilaian menunjukkan bahwa ada pengaruh latar belakang pendidikan terhadap kompetensi pedagogik guru TK. Besarnya kontribusi latar belakang pendidikan terhadap kompetensi pedagogik guru TK sebesar 19,8% sisanya 80,2% dipengaruhi oleh faktor lain yang tidak dibahas dalam penelitian ini. Dengan demikian analisis pengaruhnya adalah positif dan dibuktikan dengan nilai fhitung 7,657 f tabel4,16. Sehingga dapat disimpulkan bahwa Ha diterima dan Ho ditolak.
Fuzzy solution of nonlinear Boussinesq equation
Authors: Tzimopoulos Christos , Papadopoulos Kyriakos , Papadopoulos Basil , Samarinas Nikiforos , Evangelides Christos 
Published: November 2022

Abstract
In this paper, the solution of the one-dimensional second-order unsteady nonlinear fuzzy partial differential Boussinesq equation is examined. The physical problem concerns unsteady flow in a semi-infinite unconfined aquifer bordering a lake. In the examined problem, there is a sudden rise and subsequent stabilization of the lake's water level, thus the aquifer is recharging from the lake. The aquifer boundary conditions are considered fuzzy and, therefore, ambiguities are created to the solution of the overall physical problem. Then, the fuzzy problem is translated to a system of crisp boundary value problems. By using a Boltzmann transformation, the crisp problem is transformed into an integro-differential equation and solved with the help of a special numerical method. This method has a simple iterative procedure, which converges rapidly and is proven very accurate in comparison with other analytical methods. Additionally, the algebraic equation estimates very close to the storage coefficient, the flux at the stream-aquifer origin, and the water stored volume with respect to other exact solutions. This method is very useful for practical cases (artificial recharge problems, irrigation, and drainage projects), giving the possibility to decision-makers to take the right decision.
Introduced flow variability and its propagation downstream of hydropower stations in Sweden
Authors: Elenius Maria Teres , Lindström Göran 
Published: November 2022

Abstract
Hydropower regulations may increase flow variability when compared with the natural hydrological regime, with detrimental impacts on river habitats. Attenuation of the variability improves ecological status at some distance downstream of the introduced variability, and being able to accurately estimate this distance is critical for the evaluation of ecological status. The attenuation has only been studied previously for specific rivers, and the dominant mechanisms have not been analyzed in detail. In this work, the attenuation and its important drivers are studied for regulated rivers in all of Sweden by comparing Fourier components and their attenuation based on hydrological and hydraulic models and observations, with comparisons also to lake attenuation. In many rivers, weekly flow variability is dominant among periods up to 1 month, and variability with periodicity days to months attenuates with an exponential rate that is largest for short periods. This is mainly driven by instream processes. Furthermore, regulated systems often resemble cascades with low-gradient river stretches between the dams. The associated attenuation can be described by hydrological models using a linear channel and linear reservoir. In contrast, the sometimes-used diffusion wave equation is often unable to replicate the observed attenuation here. Lakes may contribute significantly to attenuation.
Investigating the influences of concave depths on stormwater runoff and pollution retention of urban grasslands
Authors: Liu Wen , Lu Zhixiang 
Published: November 2022

Abstract
In this study, scale-based runoff plots of concave grasslands were designed and simulated rainfall experiments were conducted to investigate their retention effectiveness for runoff volume and pollutant loads, and to analyze the influences of concave depths on runoff and pollution retention of grasslands. Results showed that mean time to runoff of concave grasslands was 88.5 minutes, which was 5.3 times than that of flat grassland. Average peak flow rate of concave grasslands was reduced by 36.2% compared with flat grassland. Concaved grasslands averagely retained 58.2% of stormwater runoff. Deeper concave depths significantly increased runoff detention and retention performance of grasslands. Total suspended solids (TSS) load reduction rates of concave grasslands were ranged from 50.8% to 97.3%. Total nitrogen (TN) load reduction rate was 49.8% for concave depth of 10 cm. Total phosphorus (TP) load reduction rates were 45.0% and 93.9% for grasslands with 5 cm and 10 cm concave depths, respectively. Pollution load reduction rates of TSS, TN and TP enhanced along with the increase in concave depths. The estimated minimum area ratios of upslope impervious surface to grasslands of 5 cm and 10 cm concave depths were approximately 1:1 under 20 mm rainfall events, and 38:1 under 5 mm rainfalls, respectively.
Analysis of the chloride ion removal mechanism from simulated wastewater by discarded vitamin tablets
Authors: Wang Xing , Gao Kangning , Ma Jingyi , Liu Feihong , Wang Xi , Li Dengxin , Yang Ming 
Published: November 2022

Abstract
Vitamin (VM) tablets are often discarded or incinerated as medical waste, and untreated highly chlorinated wastewater is discharged, polluting the environment. In this study, Cu2+ was reduced by vitamin C (VC, a component of VM), and the precipitate formed by the reaction of its product with Cl− in water was used to remove Cl− from simulated wastewater. This allows for the resourceful use of waste VM, while also achieving the goal of dechlorinating wastewater. Meanwhile, the effect of various parameters on dechlorination was studied, and the dechlorination mechanism was analyzed. According to the results, the removal rate of Cl− increased first and then decreased with pH, removal time and reaction temperature. Using VC in VM to dechlorinate simulated wastewater, the removal rate of Cl− was 94.31% under optimum conditions: pH 2.5, temperature 30 °C and reaction time 10 minutes. According to the dechlorination process, it can be inferred that Cu2+ is reduced to Cu+ by VC, and Cu+ and Cl− coprecipitate to remove Cl−. Therefore, it is feasible to use discarded VM to treat high concentration chlorine-containing wastewater.
Heterogeneous multi-population competitive algorithm and its application in ASM1 parameter estimation
Authors: Du Xianjun , Peng Yu 
Published: November 2022

Abstract
Activated sludge model 1 (ASM1) is a biokinetic model of the activated sludge wastewater treatment process, which has several uncertain parameters and complex chemical reaction processes. This model is often used in simulations to assess whether the effluent quality of wastewater meets discharge standards. Accurate and rapid estimation of the parameters of ASM1 is a necessary prerequisite for its successful application in industrial practice. However, ASM1-based parameter estimation is difficult to implement in practical operations due to the slow convergence rate and low convergence accuracy of most parameter estimation algorithms as well as the non-uniqueness of parameter estimation. In view of this, a novel metaheuristic optimization algorithm combining Legendre function network and dynamic partitioning strategy, named heterogeneous multi-group competitive algorithm (HMCA), is proposed to overcome the problem of low algorithmic efficiency and poor practicality in parameter estimation. The performance of the algorithm in terms of convergence speed, convergence accuracy and applicability is verified by two sets of test functions and eight state-of-the-art comparison algorithms. The superior performance of the algorithm in parameter estimation is then validated in conjunction with Benchmark Simulation Model no. 1 (BSM1) and four sets of operational data.
Identification of a Peptide Binding To the Hiv-1 Nucleocapsid Protein (Ncp7)
Authors: Calogero Raffaele A. , Lener Daniela , Antico Gianni , del Gaudio Rosanna , Aulicino Anna , Geraci Giuseppe 
Published: November 2022

Abstract:
In HIV-1 the nucleocapsid protein (NC) is essential in the virion assembly process. The discovery of substances able to interfere with the HIV-1 NC functions could be a starting point for the design of new drugs that might inhibit the HIV-1 viral infectivity. A single peptide sequence binding to the NC was isolated using a conformationally homogeneous phage displayed-peptide library. The minimal requirement for the NCp7/peptide interaction was the NCp7 region encompassing the second zinc finger.
The Use of MALDI-TOF Mass Spectrometry In Quantification of the Stability of Prolyl Endopeptidase Inhibitors
Authors: Demuth Hans-Uirich , Schmidt Jorn , Wermann Michael , Rosche Fred 
Published: November 2022

Abstract:
Z-Phe-Pro-(isonicotinic acid methylester) methylketone is a highly potent inhibitor (Ki*= 18 nM) of prolyl
endopeptidase from Flavobacterium meningosepticum. It acts as a slow-binding inhibitor and decomposes to compounds still possessing inhibitory activity.The pathway of decomposition was analyzed qualitatively and quantitatively applying MALDI-TOF mass spectrometry.
Semi-parametric Model to Study the Risk Factors of Tuberculosis among Adult men in South Africa
Authors: Mlondo Muziwandile Nhlakanipho , Melesse Sileshi Fanta , Mwambi Henry G. 
Published: November 2022

Background:Understanding the relationship between tuberculosis and the risk factors of tuberculosis is vital to be able to address them. Even though tuberculosis is curable and preventable, it remains a public threat, especially in low- and middle-income countries. There are more cases of men infected with tuberculosis compared to women.Methods:This study determines the risk factors that influence TB infection among adult men in South Africa. The Generalized Additive Mixed Models that incorporate a nonparametric smooth additive function were used to analyze the 2016 South African Demographic Health Survey. The Generalized Additive Model and Generalized Additive Mixed Model were compared to find the most suitable model.Results:The finding reveals that the significant determinates associated with tuberculosis were: region, primary education compared to secondary, race, health, weight, and wealth index, which were modeled parametrically. The conclusion is that only the interaction effect of age and number of times away from home were significant in variables modeled non-parametrically.Conclusion:In conclusion, the South African government needs to intervene on men living in Western Cape, Eastern Cape, Northern Cape, Free State, and men with poor health - to reduce South Africa’s infections. The government should also implement programs that will teach and discourage lower body mass index. Thus, targeting the factors that have a positive significant effect among adult men can help to reduce the risk of having tuberculosis.