bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proton pump inhibitors‐related subacute cutaneous lupus erythematosus: Clinical characteristics, management, and outcome
Authors: Deng Zhenzhen , Guo Aiyuan , Wu Cuifang , Wang Chunjiang 
Published: October 2022

AbstractPurposePrevious knowledge about the association between proton pump inhibitors (PPIs) exposure and subacute cutaneous lupus erythematosus (SCLE) was mainly based on limited case reports or few review studies. We aim to evaluate the clinical characteristics, management, and outcome in patients with PPIs‐induced SCLE.MethodsCase reports and case series from 2000 to December 31, 2021, on SCLE induced by PPIs were collected and retrospectively analyzed.ResultsA total of 29 patients (6 male and 23 female) were included from 19 studies, the median age was 61 years (range 19–85), and 65.5% of patients were ≥60 years old. 37.9% of patients had the history of autoimmune diseases. The incubation period of PPIs intro to SCLE was 6 weeks for PPI‐naive patients and 2 weeks for those re‐administration of PPIs. The most common symptoms were annular and polycyclic erythematous (74.1%), rash or maculopapular (48.1%), and scaly plaques (40.7%). Trunk (69.2%), extremities (69.2%), face (26.9%), chest (26.9%), and back (26.9%) were common involved locations. Antinuclear antibodies, anti‐Ro/SSA antibodies, and anti‐La/SSB antibodies were positive in 24 patients (82.8%), 24 patients (82.8%), and 6 patients (20.7%), respectively. Direct immunofluorescence was positive in 50% of cases. Complete clinical remission (92.6%) was observed (median time: 4 weeks) with discontinuation of PPIs and treatment of oral corticosteroids (61.1%), hydroxychloroquine (44.4%), or topical steroids (16.7%).ConclusionPPIs‐related SCLE is a rare adverse reaction based on clinical manifestations associated with immunological abnormalities and suggestive histological findings. PPIs should be suspected when considering possible culprits for drug‐related SCLE.
Significance of positive peritoneal cytology for recurrence and survival in patients with endometrial cancer
Authors: Ueno Yuta , Toyoshima Masafumi , Shigemi Daisuke , Yumori Asuna , Wakabayashi Reina , Kitagawa Masakazu , Konnai Katsuyuki , Onose Ryo , Suzuki Shunji , Kato Hisamori 
Published: October 2022

AbstractAimThis study aims to examine the association between malignant peritoneal cytology and prognosis in women with endometrial cancer.MethodsWe retrospectively analyzed the records of patients with endometrial cancer who underwent surgery with intraoperative peritoneal cytology at our hospital between January 1988 and December 2012. All results were reclassified according to the 2009 International Federation of Gynecology and Obstetrics (FIGO) system, and the relation between intraoperative peritoneal cytology results and recurrence and prognosis was examined.ResultsOf the 908 patients analyzed, 205 (22.6%) had positive peritoneal cytology. Patients with positive peritoneal cytology had significantly lower rates of recurrence‐free survival (RFS) and overall survival (OS) than those in the negative cytology group (both p < 0.001). Subgroup analysis of patients with FIGO stage I/II showed significantly lower RFS in the positive‐cytology group (p = 0.005), but there was no significant difference in OS (p = 0.637). In the patients with FIGO stage III/IV or patients classified as “high risk,” the RFS and OS were significantly lower in the positive‐cytology group (both p < 0.001). Cox regression analysis identified positive peritoneal cytology as a significant predictor of recurrence in patients with FIGO stage I/II disease.ConclusionsPatients with positive peritoneal cytology for endometrial cancer have a high risk of recurrence, regardless of histopathologic type or FIGO stage. Peritoneal cytology has already been removed from the 2009 FIGO classification of endometrial cancer, but it may deserve reconsideration.
Second Language Learning via Syntactic Priming: Investigating the Role of Modality, Attention, and Motivation
Authors: Coumel Marion , Ushioda Ema , Messenger Katherine 
Published: October 2022

AbstractWe examined whether input modality and individual differences in attention and motivation influence second language (L2) learning via syntactic priming. In an online study, we compared the primed production of English passives by 235 L2 and native English speakers in reading‐to‐writing versus listening‐to‐writing conditions. We measured immediate priming (producing passives immediately after exposure to passives) and short‐ and long‐term learning (producing more passives in immediate and 1‐week delayed posttests relative to pretests). Both groups showed immediate priming and short‐ and long‐term learning, although L2 speakers produced more passives with immediate priming and showed greater long‐term learning. Learning was unaffected by modality, but immediate priming was greatest in the listening‐to‐writing condition across groups. Individual differences in attention and motivation did not influence priming or learning. Thus, syntactic priming fosters long‐term L2 learning regardless of input modality, but participants may be sensitive to the frequency of passives in spoken versus written language during immediate priming.
Disruption of plant plasma membrane by Nep1‐like proteins in pathogen–plant interactions
Authors: Pirc Katja , Albert Isabell , Nürnberger Thorsten , Anderluh Gregor 
Published: October 2022

SummaryLipid membrane destruction by microbial pore‐forming toxins (PFTs) is a ubiquitous mechanism of damage to animal cells, but is less prominent in plants. Nep1‐like proteins (NLPs) secreted by phytopathogens that cause devastating crop diseases, such as potato late blight, represent the only family of microbial PFTs that effectively damage plant cells by disrupting the integrity of the plant plasma membrane. Recent research has elucidated the molecular mechanism of NLP‐mediated membrane damage, which is unique among microbial PFTs and highly adapted to the plant membrane environment. In this review, we cover recent insight into how NLP cytolysins damage plant membranes and cause cell death.
hsa_circ_0000264 promotes tumor progression via the hsa‐let‐7b‐5p/HMGA2 axis in head and neck squamous cell carcinoma
Authors: Xue Feifei , Feng Hongjie , Wang Tianxiao , Feng Guanying , Ni Nan , Wang Ruixia , Yuan Hua 
Published: October 2022

AbstractObjectiveCircular RNAs (CircRNAs) are involved in various tumors. However, their role in head and neck squamous cell carcinoma (HNSCC) is unknown. CircRNA sequencing data showed that hsa_circ_0000264 is significantly upregulated in HNSCC tissues. In this study, we aimed to investigate the role of hsa_circ_0000264 in HNSCC and elucidate its underlying regulation mechanism.Materials and MethodsRNase R treatment was performed to confirm the loop structure of hsa_circ_0000264. Fluorescence in situ hybridization was performed to show the subcellular localization of hsa_circ_0000264. We then performed wound healing assay, Transwell assay, Western blot, and in vivo experiments to determine the effect of alterations in hsa_circ_0000264 expression. We performed RNA pull‐down and dual luciferase reporter assay to identify and confirm the binding sites in RNAs.Resultshsa_circ_0000264 was upregulated in HNSCC tissues and cells, and its loop structure was confirmed. Knockdown of hsa_circ_0000264 inhibited the migration, invasion, and epithelial‐to‐mesenchymal transition of HNSCC cells in vivo and in vitro. Mechanistically, hsa_circ_000026 upregulation can upregulate the expression of high mobility group AT‐hook 2 (HMGA2) by sponging hsa‐let‐7b‐5p, which in turn promotes HNSCC progression.ConclusionOur results showed that hsa_circ_0000264 promotes HNSCC progression via the hsa‐let‐7b‐5p/HMGA2 axis, and hsa_circ_0000264 can serve as a potential target for HNSCC treatment.
Subcutaneous versus transvenous implantable cardioverter defibrillators in children and young adults: A meta‐analysis
Authors: Vetta Giampaolo , Parlavecchio Antonio , Magnocavallo Michele , Valente Debora , Caminiti Rodolfo , Polselli Marco , Vetta Francesco , Cirone Donatello , Cauti Filippo Maria , Crea Pasquale , Rossi Pietro , Chierchia Gian Battista , Bianchi Stefano , de Asmundis Carlo , Natale Andrea , Della Rocca Domenico Giovanni 
Published: October 2022

AbstractIntroductionThe implantable cardioverter defibrillator (ICD) has been demonstrated to successfully prevent sudden cardiac death (SCD) in children and young adults. A wide range of device‐related complications/malfunctions have been described, which depend on the intrinsic design of the defibrillation system (transvenous‐implantable cardioverter defibrillator [TV‐ICD] vs. subcutaneous‐implantable cardioverter defibrillator [S‐ICD]).ObjectiveTo compare the device‐related complications and inappropriate shocks with TV‐ICD versus S‐ICD.Methods and ResultsElectronic databases were queried for studies focusing on the prevention of SCD in children and young adults with TV‐ICD or S‐ICD. The effect size was estimated using a random‐effect model as odds ratio (OR) and relative 95% confidence interval (CI). The primary endpoint was a composite of any device‐related complications and inappropriate shocks. We identified a total of five studies including 236 patients (Group S‐ICD: 76 patients; Group TV‐ICD: 160 patients) with a mean follow‐up time of 54.2 ± 24.9 months. S‐ICD implantation contributed to a significant reduction in the risk of the primary endpoint of any device‐related complications and inappropriate shocks (OR: 0.18; 95% CI: 0.05–0.73; p = .02). S‐ICD was also associated with a significantly lower incidence of inappropriate shocks (OR: 0.28; 95% CI: 0.11–0.74; p = .01) and lead‐related complications (OR: 0.18; 95% CI: 0.05–0.66; p = .01). A trend toward a higher risk of pocket complications (OR: 5.91; 95% CI: 0.98–35.63; p = .05) was recorded in patients with S‐ICD.ConclusionChildren and young adults undergoing S‐ICD implantation may have a lower risk of a composite of device‐related complications and inappropriate shocks, compared to TV‐ICD patients.
Prenatal, perinatal, postnatal risk factors, and excess screen time in autism spectrum disorder
Authors: Güneş Hatice , Tanıdır Canan , Doktur Hilal , Yılmaz Seheryeli , Yıldız Deniz , Özbek Fatih , Bozbey Sema , Özşirin Gülşah 
Published: October 2022

AbstractBackgroundThe aim of this study was to investigate pre‐, peri‐, and postnatal factors, screen time in a group of patients with autism spectrum disorder (ASD) and age and sex‐matched clinical controls to evaluate risk factors specific to ASD.MethodsThe study included 211 ASD patients (177 boys, 34 girls; mean age 44.3 ± 13.0 months) and 241 (190 boys, 51 girls; mean age 44.6 ± 14.1 months) age and sex group matched clinical controls. Non‐ASD diagnoses were expressive language disorder (n = 135, 56.0%), intellectual disability (n = 15, 6.2%), attention deficit‐hyperactivity disorder (n = 6, 2.4%), oppositional disorder (n = 6, 2.4%), and other behavioral or emotional problems (no diagnosis; n = 79, 32.8%). A sociodemographic data form was used to collect data regarding pre‐, peri‐, and postnatal factors and total daily screen exposure.ResultsAccording to our findings, maternal severe psychological stress and depression during pregnancy, and maternal postpartum depression were more frequent in the ASD group (p = 0.005, p = 0.035, and p = 0.001 respectively). There was a statistically significant difference between groups with regards to maternal any medication use during pregnancy (p = 0.004). The mean duration of daily screen exposure was higher in the ASD group (9.90 ± 5.10 h) compared to non‐ASD children (4.46 ± 3.40 h; p < 0.001). A ROC curve showed that 8.5 h and above total daily screen exposure (AUC = 0.808 [95% CI: 0.769–0.848], p < 0.001; 55% sensitivity, 90.5% specificity) is likely to be associated with increased risk for ASD.ConclusionOur study suggests that prenatal maternal psychological stress, prenatal and postpartum depression, and excess exposure to screen might be related to an increased risk for ASD.
Implications of refrigerator management on subjective memory complaints among Japanese community‐dwelling older adults
Authors: Ikeda Yuriko , Maruta Michio , Han Gwanghee , Miyata Hironori , Nakamura Atsushi , Shimokihara Suguru , Tabira Takayuki 
Published: October 2022

AbstractAimOlder adults with subjective memory complaints (SMC) may experience very minor difficulties in daily activities. Although caregivers and occupational therapists who support community‐dwelling older adults are aware of the existence of characteristic behaviours related to refrigerator management, no specific studies have been conducted. This study aimed to examine the implications of refrigerator management for older adults with SMC.MethodsA self‐administered questionnaire was sent to 3000 randomly selected members of Consumer's Co‐operative Kagoshima. Of the returned responses, a total of 282 older adults were analyzed. Analyzed subjects were divided into two groups: SMC (+) group (n = 74) and SMC (−) group (n = 192). A questionnaire was created by four occupational therapists and used to assess the characteristics of analyzed subjects and their abilities to manage the refrigerator. The observation list for early signs of dementia was also utilised. A multiple logistic analysis was performed to examine the association between SMC and refrigerator management.ResultsThe SMC (+) group had a significantly higher number of refrigerator management errors than the SMC (−) group (P = 0.008). The SMC (+) group had more errors than the SMC (−) group in the following four items regarding refrigerator management; the refrigerator has a lot of the same foods / expired food, the person does not know what's in the refrigerator, the person cannot find what he/she needs in the refrigerator. Moreover, SMC was associated with the item ‘the person does not know what is in the refrigerator’ (odds ratio 7.44, 95% CI 1.51–43.8, P = 0.02).ConclusionsOur results showed that older adults with SMC had several problems regarding refrigerator management. Evaluating refrigerator management among older adults with SMC may help consider multifaceted support.
Comparison the effects of 5‐Aza‐2′‐deoxycytidine and zebularine on the in vitro development, blastocyst quality, methylation pattern and conception rate on handmade cloned buffalo embryos
Authors: Saha Ambikaprasanna , Chauhan Manmohan S. , Manik Radhey S. , Palta Prabhat , Singla Suresh K. 
Published: October 2022

AbstractIn this study we treated the handmade cloned (HMC) buffalo embryos with the DNA methylation inhibitors; 5‐aza‐2′‐deoxycytidine (AzadC) or Zebularine individually after post‐fusion and during in vitro culture till eighth day. The blastocysts production rate significantly improved (p < .01) after treating embryos independently with 5 nM AzadC and 5 nM zebularine compared with 2 and 10 nM AzadC or zebularine groups, respectively. The highest cleavage rates were obtained for 5 nM treatment of AzadC and zebularine compared with other treatments and untreated control group. Quality of blastocysts were evaluated using total cell number (TCN) and the ratio of number of inner cell mass (ICM) cells/total cell number (ICM/TCN). Zebularine treatments (2/5/10 nM) significantly improved both TCN and ICM/TCN ratio compared with AzadC treatments (2/5/10 nM); however, control group TCN and ICM/TCN ratio was found lower. The methylation percentage of pDS4.1 and B. bubalis satellite DNA were comparatively more attenuated with 5 nM zebularine than 5 nM AzadC treatment. The increased in vitro development rates of the treated embryos were correlated with the decreased level of DNA methylation and the improved blastocyst quality. Following transfer of 5 nM zebularine treated embryos to 6 recipients, 4 were found to be pregnant, though the pregnancies were not carried to full term.
The cumulative effect of methacholine on large and small airways when deep inspirations are avoided
Authors: Henry Cyndi , Boucher Magali , Boulay Marie‐Ève , Côté Andréanne , Boulet Louis‐Philippe , Bossé Ynuk 
Published: October 2022

AbstractBackground and ObjectiveThe effect of serial incremental concentrations of methacholine is only slightly cumulative when assessed by spirometry. This limited cumulative effect may be attributed to the bronchodilator effect of deep inspirations that are required between concentrations to measure lung function. Using oscillometry, the response to methacholine can be measured without deep inspirations. Conveniently, oscillometry can also dissociate the contribution of large versus small airways. Herein, oscillometry was used to assess the cumulative effect of methacholine in the absence of deep inspirations on large and small airways.MethodsHealthy and asthmatic volunteers underwent a multiple‐concentration methacholine challenge on visit 1 and a single‐concentration challenge on visit 2 using the highest concentration of visit 1. The maximal response was compared between visits to assess the cumulative effect of methacholine. The lung volume was also measured after the final concentration to assess hyperinflation.ResultsIn both healthy and asthmatic subjects, increases in resistance at 19 Hz (Rrs19), reflecting large airway narrowing, did not differ between the multiple‐ and the single‐concentration challenge. However, increases in resistance at 5 Hz (Rrs5) minus Rrs19, reflecting small airway narrowing, were 117 and 270% greater in the multiple‐ than the single‐concentration challenge in healthy (p = 0.006) and asthmatic (p < 0.0001) subjects, respectively. Hyperinflation occurred with both challenges and was greater in the multiple‐ than the single‐concentration challenge in both groups.ConclusionWithout deep inspirations, the effect of methacholine is cumulative on small airways but not on large airways. Lung hyperinflation and derecruitment may partially explain these different responses.
Social Network‐Based Induced Abortion Incidence Estimation in Burkina Faso: Examining the Impact of the Network Generating Question
Authors: Bell Suzanne O. , Guiella Georges , Anjur‐Dietrich Selena , Bazie Fiacre , Onadja Yentema , Ahmed Saifuddin , Moreau Caroline 
Published: October 2022

AbstractSocial network‐based methods are increasingly used to estimate induced abortion incidence and investigate correlates. Approaches differ in the social tie definitions used to identify which social network members’ abortion experiences respondents will report. This study compares the effect of using the “best friend” (closest female friend) versus “confidante” (specifying mutual sharing of personal information) definition on abortion incidence estimation. We use data from a nationally representative survey of women aged 15–49 in Burkina Faso (conducted in 2020–2021) where respondents were randomized into two versions of an abortion module, using different friend definitions. We computed abortion rate estimates by friend definition and adjusted for assumption violations (transmission bias, surrogate sample selection bias). Unadjusted incidence rates varied from 11.7 [4.1–19.2] abortions per 1,000 women to 15.6 [9.7–21.4], depending on friend definition. The confidante definition yielded higher adjusted estimates (36.2 [25.1–47.2]) than the best friend definition (17.0 [8.7–25.3]) due to greater transmission bias adjustment. Both estimates exceeded the respondent self‐reported abortion incidence (4.0 [2.2–5.9]). Our results indicate that either friend definition produces higher incidence estimates than self‐report but suggest a potential advantage for the “best friend” over the “confidante” definition given lower transmission bias. Further research should assess generalizability of these findings in other contexts.
The Importance of Communication During a Bike Fit: A Call for Research
Authors: Smethurst Alex Jane , Findlay Iain Stuart 
Published: October 2022

Bike fitting is a rapidly developing profession in the field of sport and well-being. The profession is governed by the International Bike Fitting Institute, which recently announced the creation of a common education syllabus. Although this is a positive step forward, to ensure the integrity of the profession, it is important that the content of the syllabus be evidence based. This, however, may prove challenging as there is currently a paucity of research regarding certain aspects of the bike-fitting role. One area that appears to have been largely neglected is the relationship and importance of communication between the bike fitter and client. This scholarly commentary presents research from other professions that demonstrates both the importance of this omission and the necessity to include training on communication and interpersonal skills in the International Bike Fitting Institute’s proposed education provision.
Reliability of the 3-Component Model of Aerobic, Anaerobic Lactic, and Anaerobic Alactic Energy Distribution (PCr-LA-O2) for Energetic Profiling of Continuous and Intermittent Exercise
Authors: Kaufmann Sebastian , Latzel Richard , Beneke Ralph , Hoos Olaf 
Published: October 2022

Purpose: To assess the test–retest reliability of the continuous (PCr-LA-O2) and intermittent (PCr-LA-O2int) version of the 3-component model of energy distribution in an applied setting. Methods: Sixteen male handball players (age 23 [3] y, height 185 [7] cm, weight 85 [14] kg) completed the 30–15 Intermittent Fitness Test (30–15IFT) twice. Performance was assessed by peak speed (speed of the last successfully completed stage of the 30–15IFT [VIFT], in kilometers per hour) and time to exhaustion (in seconds). Oxygen uptake (in milliliters per kilogram per minute) and blood lactate concentrations (in millimoles per liter) were obtained before, during, and until 15 minutes after exercise. Total metabolic energy (in joules per kilogram), total metabolic power (in watts per kilogram), and energy shares (in joules per kilogram and percentage) of the aerobic (energy contribution of the aerobic system [WAERint]), anaerobic lactic, and anaerobic alactic (anaerobic alactic energy [WPCrint]) systems were calculated using both model versions, respectively. Results: Test–retest reliability was very good for VIFT (limits of agreement [LoA]: −1.13 to 0.63 km·h−1, coefficient of variation [CV%] 1.68), time to exhaustion (LoA: −101 to 38 s, CV% 2.92), peak oxygen uptake (LoA: −2.68 to 4.04 mL·min−1·kg−1, CV% 1.48), and peak heart rate (−6.9 to 7.7 beats·min−1, CV% 1.1), but moderate for change in blood lactate concentration (LoA: −3.84 to 4.07 mmol·L−1, CV% 11.43). Reliability of the modeled total energy and its fractions were high for total metabolic energy (LoA: −1489 to 1177 J·kg−1, CV% 2.88), total metabolic power (LoA: −2.0 to 1.9 W·kg−1, CV% 3.58), contribution of aerobic (LoA: −1673 to 1283 J·kg−1, CV% 3.62), WAERint (LoA: −1760 to 2160 J·kg−1, CV% 6.04), and moderate for anaerobic alactic (LoA: −368 to 439 J·kg−1, CV% 14.85), WPCrint (LoA: −1707 to 988 J·kg−1, CV% 9.98), and energy share of anaerobic lactic concentration (LoA: −229 to 235 J·kg−1, CV% 11.43). Conclusion: Considering the inherent fluctuations of the underlying energetics, the reliabilities of both versions of the 3-component model of energy distribution are acceptable for applied settings.