bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-speed rail opening and environmental pollution in China-- Test based on multi-point DID model
Authors: Wang Shijin , Qiu Jie 
Published: November 2022

Abstract
In recent years, environmental problems have attracted attention at home and abroad, so exploring the causes of environmental pollution has become the research content of scholars .The opening of high-speed railway has improved the level of economic development in China's Yangtze River Delta, and with the economic growth, the construction of high-speed railway has also led to the environmental pollution in China's Yangtze River Delta.Therefore, the panel data of 41 prefecture-level cities in China's Yangtze River Delta from 2003 to 2018 were used to construct a multi-time point DID model, and the environmental pollution comprehensive index was calculated by factor analysis method to calculate the impact of high-speed railway construction on environmental pollution China's Yangtze River Delta. The conclusion is as follows: the opening of high-speed railway significantly reduces the overall pollution level in China's Yangtze River Delta.The opening of high-speed rail has played a role in restraining the environmental pollution of the first and second tier cities and the third and fourth tier cities, but the pollution level of the third and fourth tier cities has decreased significantly.
Gamma-band (30-40 Hz) connectivity during hypnosis in individuals with equal high hypnotizability but different dissociative experiences: a preliminary study
Authors: Taghilou Hoda , Rezaei Mazaher , Nazari Mohammad Ali , Valizadeh Alireza 
Published: November 2022

Abstract
Background
Most electrophysiological studies in hypnosis have divided individuals into two groups with high and low hypnotizability. However, this classification has been subjected to considerable criticism. The most important of these criticisms is that highly hypnotizable individuals can be divided into different groups due to their heterogeneity.
Methods
We selected 20 people with a score of eight or higher on the Stanford Hypnotic Susceptibility Scale C (SHSSC). We recorded the 19-channel EEG activity of the subjects in pre-hypnosis (baseline) and hypnosis conditions. We performed Dissociative Experiences Scales (DES) on them. We divided the subjects based on their DES score into two groups as high dissociative (HD) and low dissociative (LD). We predict that the two groups will have different gamma-band (30–40 Hz) connectivity despite equal hypnotizability.
Results
We found that both highly hypnotizable groups had reduced gamma connectivity during hypnosis. However, the characteristic gamma connectivity changes in the LD group decreased in the interhemispheric medial frontal cortex (MPFC). Furthermore, the HD group showed reduced gamma connectivity in the left frontotemporal network.
Conclusions
Indeed, the LD group showed reduced gamma in the "default mode network" and the HD group in the "executive control network".
Translumental Nd:YAG Laser Embolysis for the Treatment of Branch Retinal Artery Occlusion
Authors: Zhao Jie , Liu Xiuduo , Xu Huidi , Wang Qian , Lu Qing 
Published: November 2022

Abstract
Objective
To investigate the clinical effect of translumental Nd:YAG laser embolysis(TYE) in the treatment of branch retinal artery occlusion(BRAO) for the patients with initial best corrected visual acuity(BCVA) no more than 20/100 and more than 24 hours from onset to visit.
Material and Methods
In this study, a total of 8 affected eyes(8 patients, 5 male and 3 female)with sight-threating BRAO received TYE therapy. All patients had a visible embolus within the affected eye. The mean age of the patients was 75.4 ± 6.3 years (range, 66–85 years). All the time from onset to initial visit to our hospital was more than 24 hours. The mean treatment time from onset were 7.4 ± 4.1 days (range, 2–14 days). Before the TYE treatment, the BCVA of all affected eyes was 20/100 or worse. All patients underwent BCVA test, fundus photography, optical coherence tomography(OCT), and central visual field(CVF) examination from the first to final visit.
Results
After the TYE treatment, all the cases showed immediate recovery of blood flow in the occluded branch retinal artery. The reperfusion of the blocked artery was observed in all affected eyes by fundus examination and fundus photography. The diameter of the affected branch retinal arteries increased significantly. The BCVA improved significantly by a average of 5.7 lines(rang 1–11 lines) in all patients. The BCVA of the affected eyes at the last follow-up were significantly improved compared before TYE treatment(P < 0.01). Before treatment the average MS was 11.2 ± 2.51, the average MS at the last follow-up time was 11.7 ± 3.55. There was no statistically significant difference in mean MS between pretreatment and at the last follow-up(P > 0.05). During the TYE treatment, mild retinal and vitreous hemorrhage usually happened which gradually absorbed in no more than 2 weeks.
Conclusion
Translumental Nd:YAG laser embolysis may be a safe and effective method to significantly improve the prognosis of BRAO in patients with initial BCVA no more than 20/100 and more than 24 hours from onset to visit.
Bioorganic Two-Photon Nanoprobes with a Photo-Oxidation Enhanced Emission Mechanism
Authors: Yan Xuehai , Li Shukun , Zhao Luyang , Xing Ruirui , Hest Jan C.M. van 
Published: November 2022

Abstract
Two-photon absorption (TPA) fluorescence imaging holds great promise in diagnostics and biomedicine owing to its unparalleled spatiotemporal resolution. However, the adaptability and applicability of currently available TPA probes, which act as a critical element for determining the imaging contrast effect, is severely challenged by limited photoluminescence in vivo. This is particularly a result of uncontrollable aggregation that causes fluorescence quenching, and inevitable photo-oxidation in harsh physiological milieu, which normally leads to bleaching of the dye. Herein, we describe the remarkably enhanced TPA fluorescence imaging capacity of self-assembled near-infrared cyanine dye-based nanoprobes (NPs), which can be explained by a photo-oxidation enhanced emission mechanism. Singlet oxygen generated during photo-oxidation enables chromophore dimerization to form TPA intermediates responsible for enhanced TPA fluorescence emission. The resulting NPs possess uniform size distribution, excellent stability and a more favorable TPA cross-section than a widely-used TPA probe rhodamine B. These properties of cyanine dye-based TPA NPs promote their applications in visualizing blood circulation and tumoral accumulation in real-time, even to cellular imaging in vivo. The unprecedented photo-oxidation enhanced emission mechanism observed in these near-infrared cyanine dye-based nanoaggregates opens an avenue for design and development of more advanced TPA fluorescence probes.
Diversity and molecular characterization of Insect - specific Flavivirus in mosquitoes (Diptera: Culicidae) collected in Central and Northern Argentina.
Authors: Farias Adrian Alejandro , Laberdolive Victoria , Stein Marina , Juri María Julia Dantur , Visintin Andrés , Almirón Walter R. , Contigiani Marta S. , Re Viviana E. , Diaz Adrián 
Published: November 2022

Abstract
In order to study the diversity and phylogenetic relationships among insect-specific flaviviruses circulating in the central and northern regions of Argentina we performed molecular detection and characterization of the NS5 protein gene in mosquitoes collected in Córdoba, Chaco and Tucumán provinces between 2001 and 2012, Sixty eight out of 1776 pools were positive. The KRV, CFA and CxFV viruses were detected by the generic PCR method, achieving the analysis of the existing phylogenetic relationships in the Flavivirus genus and the characterization of circulating CxFV in Argentina. It has also been possible to detect, for the first time, the CxFV virus in the mosquito species Haemagogus spegazzini.
Down syndrome markers classification via dense neural network in ultrasound foetal image
Authors: Pregitha Evelin , Kumar R. S. Vinod , Kumar C. Ebbie Selva 
Published: November 2022

Abstract
Down syndrome is a genetically born disorder among infants that occurs during the development of the foetus. Trisomy 21, a chromosome imbalance disorder is a leading cause of the Down syndrome. Numerous Machine Learning (ML) models have been used to identify Down syndrome in ultrasound images of foetuses, but the development of Deep Learning (DL), offers an enormous advantage over ML models in accuracy. However, the existing models have focused on Down syndrome as a Nasal bone length or Nuchal translucency. In this paper, an Automatic dense convolution neural network (DConN) is proposed to isolate and measure the Down syndrome marker particularly Nasal bone length and Nuchal translucency. It is necessary to extract texture features precisely from ultrasound images to classify them accurately. Initially, the test image is processed using an Anisotropic Diffusion Filter (ADF) to remove the noise. Then the ROI region is segmented and classified using a dense convolution neural network. The parameters namely sensitivity, accuracy, specificity, F1 score, and precision are considered for validating the effectiveness of the proposed model. The proposed method improves the overall accuracy of 3.9%, 1.6% and 0.41% better than cascaded ML, SIFT+GRNN and Modified AdaBoost respectively.
Utilization of durian seed for Monascus fermentation and its application as a functional ingredient in yogurt
Authors: Sria Ignatius , Kuswardani Indah , Ristiarini Susana , Kusumawati Netty , Godelive Laura , Nugerahani Ira 
Published: November 2022

Abstract
As a widely consumed fermented milk product, yogurt undergoes constant development to increase its functional properties. Monascus purpureus-fermented durian seed, which has been proven to possess antioxidative properties, has the potential to improve on yogurt properties. The purpose of this study was to analyze the use of Monascus-fermented durian seed (MFDS) as a functional ingredient on yogurt and its effect on physicochemical properties, lactic acid bacteria (LAB) count, antioxidative properties, and consumer acceptability of set-type yogurt during refrigeration. Changes in physicochemical properties, including color, pH, titratable acidity, and syneresis, LAB count, total phenolic content (TPC), and antioxidant activity were evaluated at 7-day intervals during 14 days of refrigerated storage (4⁰C). Sensory evaluation were carried out for freshly made samples and after 7 days of storage. Results showed that the addition of MFDS to yogurt gave significant effects to some of the parameters measured. Yogurt with added MFDS powder produced a more red color (L = 88.55 ± 1.28, a* = 2.63 ± 0.17, b* = 11.45 ± 1.15, c = 11.75 ± 1.15, H = 77.00 ± 0.64), reached the highest TPC (2.21 ± 0.46 mg/GAE g), antioxidant activity (0.0125 ± 0.0032 mg GAE/g), and syneresis (5.24 ± 0.51%) throughout 14 days of storage. Addition of MFDS only gave a slight difference to pH and titratable acidity, while no significant difference was made for LAB count. For sensory evaluation, addition of MFDS, particularly the ethanol extract, to yogurt was well liked by panelists. Overall, addition of MFDS has a high potential of improving properties of yogurt, particularly its antioxidative properties.
Motivational components involved in the metamotivational monitoring in medical students
Authors: Norouzi Ali , Parmelee Dean , Shariati Mohammad , Norouzi Saiideh , Alizadeh Maryam 
Published: November 2022

Abstract
Background: Theoretical implications of self-regulated learning emphasize that self-regulation of motivation (metamotivation) plays an important role in learning, effort, perseverance, and academic success in general. Metamotivation is how people monitor and control their motivational states to achieve their goals. Researchers believe that metamotivation includes two reciprocal processes: metamotivational monitoring, evaluating whether the person has selected the proper level (quantity) and type (quality) of motivation to perform his tasks; and metamotivational control, using the results of the monitoring phase and applying suitable strategies for adapting or changing the motivation. In metamotivational monitoring, students try to identify the declined motivational component in order to regulate its quantity and quality using motivational regulation strategies. In this field, two important questions arise: How can identify and measure the motivational components involved in metamotivational monitoring? and: Which motivational component is targeted by the medical students when they use every motivational regulation strategy?
Methods: Applying a multi-stage study, motivational components involved in metamotivational monitoring were characterized and a questionnaire developed. Then, using Structural Equation Modeling, predictive relationships between motivational components and motivational regulation strategies were investigated.
Results: The Motivational Components Questionnaire (MCQ) showed acceptable evidence of validity and reliability. In the Exploratory Factor Analysis, 6 factors were discovered that explained 74% of the total variance. In examining the predictive relationships, each of the four components of self-efficacy, intrinsic value, self-relevant value and promotion value were specifically predicted by two motivational regulation strategies.
Conclusions: Evidence of validity and reliability of the MCQ indicates that this questionnaire can be used in medical education contexts. Health Profession Educators can improve the academic motivation of students by identifying one or more declined motivational component and teaching specific motivational regulation strategies. It is recommended to hold training courses on motivational regulation strategies for medical school faculty, study-skills advisors, and students.
Survival benefit of neoadjuvant hepatic arterial infusion chemotherapy followed by hepatectomy for hepatocellular carcinoma with portal vein tumor thrombus
Authors: Hu Zili , Yang Zhenyun , Wang Jiongliang , Fu Yizhen , Hu Zhiwen , Zhou Zhongguo , Chen Minshan , Zhang Yaojun 
Published: November 2022

Abstract
background/purpose: The prognosis of hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) is generally poor and hepatectomy is optional for these patients. This study aims to explore the survival benefits of neoadjuvant hepatic arterial infusion chemotherapy (HAIC) for resectable HCC with PVTT.
Methods: This retrospective study included 120 consecutive HCC patients with PVTT who underwent hepatectomy, from January 2017 to January 2021 at Sun Yat-sen University Cancer Center. Of these patients, the overall survival (OS) and recurrence-free survival (RFS) of 55 patients who received hepatectomy alone (Surgery group) and 65 patients who received neoadjuvant HAIC followed by hepatectomy (HAIC-Surgery group) were compared. Logistic regression analysis was conducted to develop a model predicting the response to neoadjuvant HAIC.
Results: The OS rates for the HAIC-Surgery group at 1, 3, and 5 years were 94.9%, 78% and 66.4%, respectively, compared with 84.6%, 47.6% and 37.2% in the Surgery group (P < 0.001). The RFS rates were 88.7%, 56.2% and 38.6% versus 84.9%, 38.3% and 22.6% (P = 0.002). The subgroup analysis revealed that the survival benefit of neoadjuvant HAIC was limited to patients who responded to it. The logistic model, consisting of AFP and CRP, that predicted the response to neoadjuvant HAIC performed well, with an area under the ROC curve (AUC) of 0.756.
Conclusion: Neoadjuvant HAIC followed by hepatectomy is associated with a longer survival outcome than hepatectomy alone for HCC patients with PVTT and the survival benefit is limited to patients who respond to neoadjuvant FOLFOX-HAIC.
Association between Geriatric Nutritional Risk Index and Invasive Candidiasis in Critical Care
Authors: Tao Heqing , Ni Ziyan , He Shuying , Chen Kequan , Yang Zhandong , Peng Liang , Chen Xueqing 
Published: November 2022

AbstractBackground Invasive candidiasis is a common infectious complication in geriatric critical care patients, which is thought to be related to malnutrition. The geriatric nutritional risk index (GNRI) score is an integrative and convenient tool to dynamically and comprehensively assess a patient’s current nutritional status. Thus, this study aims to assess the association between GNRI scores and invasive candidiasis in geriatric critical care patients. Methods A total of 5390 patients from the MIMIC-IV database were included in the training cohort to develop disease prediction models by logistic regression, Gradient Boosting Machine (GBM), eXtreme Gradient Boosting (XGBoost), Light Gradient Boosting Machine (LightGBM), and Random Forest (Rf) model. Developed models were validated in the test cohort consisting of 2766 patients from the MIMIC-III database. The area under the receiver operating curve (AUC) is used to represent the predictive performance of the different models. Results A decreased GNRI was significantly associated with invasive candidiasis in geriatric critical care patients (P < 0.001). The AUCs for the Rf model and GBM model were not significantly different than that of the logistic regression model (0.7093 versus 0.683;P = 0.4562; 0.6874 versus 0.683;P = 0.9178) in test cohort. The AUCs for the XGBoost model and LightGBM model were significantly lower than that of the logistic regression model (0.511 versus 0.683;P < 0.001; 0.6874 versus 0.592;P < 0.001) in the test cohort. Further analysis showed that GNRI as a continuous variable rather than a categorical variable is more valuable for predicting invasive candidiasis in our cohort. Conclusion Lower GNRI score was significantly associated with an increased risk of invasive candidiasis in geriatric ICU patients. Machine learning, particularly the GBM model and Rf model, can help in the prediction of invasive candidiasis.
Dissect high-resolution genetic architecture of complex phenotypes by accurately estimating gene-based conditional heritability
Authors: Li Miaoxin , Jiang Lin , Miao Lin , Tang Bin , Sham Pak 
Published: November 2022

Abstract
Despite many methodological studies on the global heritability estimation of complex traits, very few methods have been designed to dissect local heritability accurately. A precise local heritability would provide a high-resolution map for precision medicine. We report an effective heritability estimator (EHE) for local heritability estimation using p values from genome-wide association studies (GWAS). With a directly converting marginal heritability to the effective one, EHE shows higher accuracy and is the only method correctly calculating standard errors of local heritability estimation among the four compared methods. Importantly, EHE can be directly used to estimate the conditional heritability of nearby regions or genes in which the redundant heritability can be cleaned. The conditional heritability estimation procedure can be supervised by tissue-specific expression profiles to prioritize and quantify functionally more important genes of complex phenotypes. Applying EHE to 42 complex traits from the UK biobank, we found that heritability density in lncRNA genes tends to be higher than protein-coding genes, and genes pleiotropic to more phenotypes are not enriched for more heritability among candidate susceptibility genes. EHE provides an efficient way to finely and precisely dissect the genetic architecture of complex phenotypes.
Light use in the plant factory: changes in chlorphyll fluorescence and gas exchange parameters of two lettuce cultivars at LED spectra in floating hydroponics
Authors: Roosta Hamid Reza , Soufi Hamid Reza , Kalaji Hazem M. , Malekzadeh Khalil , Hamidpour Mohsen 
Published: November 2022

Abstract

Artificial light source is one of the most important factors for high quality and quantity vegetable production in plant factory. With the aim of investigating the role of light spectra on chlorophyll fluorescence, photosynthesis, and stomata parameters in lettuce plants grown in plant factory, a factorial experiment was conducted based on a completely randomized design with two lettuce cultivars (Rossa and Bionda) and four spectra LED illumination red (656 nm), red/blue (3:1) (656 nm), blue (450 nm), and white (449 nm). The results showed that blue and white LED light had the most significant effect on chlorophyll fluorescence parameters Fo, Fm, Fv, Area and PIabs in both lettuce cultivars compared to the other light treatments. The results also showed that the combination of red and blue LED light had the highest effect on stomatal conductance (gs), number of stomata, length and width of stomata in both lettuce cultivars. On the other hand, the maximum substomatal CO2 concentration (Ci) was observed in both lettuce cultivars when treated with red LED light. Also, transpiration rate (E) increased with the combination of red and blue LED in Rossa cultivar and red LED in Bionda cultivar. The results also showed that the maximum CO2 assimilation rate (A) was observed in Rossa cultivar under white LED and in Bionda cultivar under blue LED light. It is concluded that chlorophyll fluorescence characteristics and photosynthetic and stomatal properties can be affected by different spectra and cultivars of lettuce.
Intraoral Occlusal Adjustment Time and Volume Required for CAD/CAM Crowns Fabricated Using Different Virtual Mounting Methods (A Randomized Clinical Trial)
Authors: Elkady Aly , Ameen Shereen , Sami Rasha 
Published: November 2022

Abstract
OBJECTIVE: To measure the required clinical time and volume of occlusal adjustment when the maxillary cast in a virtual articulator is set using one of three methods: a face scan, average value alignment and digitization of a conventionally mounted articulator.
MATERIALS AND METHODS: In this randomised, triple blind, crossover trial; 11 molars requiring a single crown restoration were enrolled. Three crowns were designed and milled for every participant molar. Each of the three crowns was fabricated with the participant’s casts virtually mounted utilizing a different virtual mounting method. An impression was taken of the crown in place prior to occlusal adjustment. Occlusal adjustment was then performed and timed. After the occlusal adjustment, an impression of the adjusted crown was taken. The pre-adjustment and post-adjustment impression were superimposed and volumetrically analyzed to determine the volume of occlusal adjustment performed. Kruskal-Wallis test was used to compare between the groups.
RESULTS: No statistically significant difference in occlusal adjustment time or volume was found between crowns fabricated with different virtual mounting methods.
CONCLUSIONS: A simplified approach in virtual articulator mounting appears to be justified in construction of single full coverage prosthesis. Added labor, time and cost of more elaborate virtual mounting methods seem to be counterproductive.