bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does sternal body shape reflect family relationships? A study on a genealogically documented Central European osteological sample (19th–20th centuries)
Authors: Cvrček Jan , Kuběna Aleš Antonín , Jor Tomáš , Naňka Ondřej , Drtikolová Kaupová Sylva , Velemínský Petr 
Published: September 2022

AbstractIn forensic contexts, sternal anatomical varieties represent useful tools for the identification of an individual, either by comparison of ante‐mortem and post‐mortem data, or by potential comparison of data from biologically related individuals. Sternal body variation is also used to detect the biological affinity of individuals in bioarchaeology. However, no study has been made available to date on the degree to which the overall shape of the sternal body reflects the degree of biological relatedness. We, therefore, analyzed the sternal body shape of 10 individuals with known genealogical data, members of one family over three generations including inbred individuals (19th–20th centuries, Bohemia, Czech Republic), and a control sample of 12 biologically unrelated individuals. First, closely biologically related individuals were compared with unrelated individuals based on 10 variables expressing the morphological characteristics of the sternum, and then all individuals were compared based on Fourier analysis depending on their degree of relationship. The results showed that there is a greater degree of shape similarity in biologically related individuals than in unrelated individuals, and variability decreases with an increasing degree of relatedness. Inbred individuals showed the lowest sternum‐shape distances and degree of variability, while unrelated individuals, showed the highest distances and variability. Moreover, in some cases, the documented relationships were also supported by a similar morphology of the ossified and fused xiphoid process. Thus, sternal shape analysis expands the possibilities for individual identification and the detection of the biological affinity of individuals for both the forensic sciences and bioarchaeology.
Atmospheric heat source/sink response to the snow depth over the Tibetan plateau in melting season: A modeling study
Authors: Xiao Zhixiang , Wang Ziqian 
Published: September 2022

AbstractAtmospheric heat source/sink (AHS) of the Tibetan Plateau (TP) is strongly linked to the local snow depth. Based on the numerical simulations with Weather Research and Forecasting (WRF) model, connections between snow depth and the AHS across the TP in melting season (May–August) are investigated. Compared with the derived AHS from reanalysis data, spatial patterns and monthly evolution of the AHS are reasonably reproduced by the WRF model. The AHS can be significantly reduced (~80 W m−2) by snow over both the western and southeastern TP in early May, which is mainly ascribed to the weakened surface sensible heat (SH) and atmospheric latent heat. Obvious cooling effect of snow on the AHS is still found over the western TP even in mid‐summer. However, the cooling strength in late summer has declined to one‐fifth that of May and it is totally dominated by the reduced surface SH. As to the southeastern TP, snow is thin and scattered since June, resulting that the AHS response to snow depth declines significantly and even vanishes in mid‐summer. It is further clarified that there is no elevation‐dependent relationship between the AHS and snow over the TP, while the cooling amplitudes of the AHS varied with altitude are mainly determined by the corresponding snow depth.
Dauerhafter Schutz vor Korrosion – Glasfaserverbundwerkstoff als Bewehrung von Bodenplatten in Tiefgaragen
Authors: Krämer Jonas , Weber André 
Published: September 2022

AbstractKorrosionsschäden bei Parkdecks und Tiefgaragen sind für die Betreiber ein teures und unerfreuliches Dauerthema. Wenn in den Stahlbetonbauteilen Wasser und Luft durch Risse im Beton bis zum Bewehrungsstahl vordringen, beginnt dieser zu korrodieren. Die in fast jedem Parkbauwerk vorhandenen Chlorideinträge, bspw. durch Tausalz im Winter, verstärken und/oder initiieren die Korrosion. Am häufigsten sind Bodenplatten betroffen, da hier eine besonders hohe mechanische Beanspruchung besteht. Konventionell und präventiv werden solche Bauten durch instandhaltungsintensive Oberflächenbeschichtungen vor Korrosionsschäden geschützt. Als langlebige und wirtschaftliche Lösung bietet sich eine Bewehrung aus Glasfaserverbundwerkstoff an. Dieser ist hochfest, chemisch beständig und korrosionsresistent, wodurch hohe Instandhaltungskosten vermieden werden.
Victim reactions to being stalked: Examining the effects of perceived offender characteristics and motivations
Authors: Randa Ryan , Reyns Bradford W. , Fansher Ashley 
Published: September 2022

AbstractThe current research utilized the National Crime Victimization Survey Supplemental Victimization Survey to investigate stalking in the United States. These data, collected from stalking victims, address the relationship between victims' perceptions of the stalker's motives on two post‐victimization outcomes. Specifically, we examined the relationship between the victim's assessment of motive and the degree of harm they reported, along with exploring the relationship between harm and the likelihoods of engaging in self‐protective behaviors. Here, harm was measured through an index of specific fears, concerns, and emotional distresses. We found that the frequency of stalking behaviors, the duration of the stalking experience, and the overall invasiveness of the victimization, in addition to certain motives, were positively correlated with harm. Furthermore, we found that harm was positively correlated with a number of protective actions. For researchers, this work may serve to provide entry points in the development of new grounded theory. For practitioners in law enforcement, this work may provide insights into the invasive nature of stalking and the fear and harm caused to the victim.
Polymerization increasing the capacitive charge storage for better rate performance: A case study of electrodes in aqueous sodium‐ion capacitors
Authors: Gu Chengjun , Liu Zhihao , Gao Xiang , Zhang Qi , Zhang Zhanhui , Liu Zhitian , Wang Chengliang 
Published: September 2022

AbstractOrganic molecules and polymers have been widely used in aqueous sodium‐ion capacitors. However, the difference in the reaction kinetics of the electroactive polymer and its monomer has been overlooked. In this study, a comparative study of the sodium‐ion storage performance and the reaction kinetics is performed. The poly(perylene diimides) which is named EDP exhibits decreased crystallinity, smaller particle size with a rough surface, higher specific capacitance, lower reduction potential, better cycling stability, and rate performance, compared with its monomer 3,4,9,10‐perylenetetracarboxylic dianhydride. The reaction kinetics study proves that the EDP shows faster sodium‐ion diffusion and more capacitive charge storage, which are responsible for the high‐rate capability.
Identification of a pyroptosis‐based model for predicting clinical outcomes from immunotherapy in patients with metastatic melanoma
Authors: Wu Guanghao , Chen Biying , Jiang Junjie , Chen Yiran , Chen Yanyan , Wang Haiyong 
Published: September 2022

AbstractImmunotherapy has greatly improved outcomes for patients with advanced melanoma, but good predictive biomarkers remain lacking in clinical practice. Although increasing evidence has revealed a vital role of pyroptosis in the tumor microenvironment (TME), it remains unclear for pyroptosis as a predictive biomarker for immunotherapy in melanoma. RNA sequencing data and annotated clinical information of melanoma patients were obtained from four published immunotherapy datasets. LASSO regression analysis was conducted to develop a pyroptosis‐based model for quantifying a pyroptosis score in each tumor. Based on four clinical cohorts, we evaluated the predictive capability of the model using multiple immunotherapeutic outcomes, including clinical benefits, overall survival (OS), and progression‐free survival (PFS). Furthermore, we depicted the distinctive TME features associated with pyroptosis. Compared with the group with low pyroptosis scores, the group with high pyroptosis scores consistently achieved better durable clinical benefits in four independent cohorts and the meta‐cohort. ROC analysis validated that the pyroptosis‐based model was a reliable biomarker for predicting clinical benefits from immunotherapy in melanoma. Survival analyses showed that the group with high pyroptosis scores harbored more favorable OS and PFS than those with low pyroptosis scores. Molecular analysis revealed that tumors with high pyroptosis scores displayed a typical immune‐inflamed phenotype in TME, including enrichment of immunostimulatory pathways, increased level of tumor‐infiltrating lymphocytes, upregulation of immune effectors, and activation of the antitumor immune response. Our findings suggested that the pyroptosis‐related model associated with multiple immune‐inflamed characteristics might be a reliable tool for predicting clinical benefit and survival outcomes from immunotherapy in melanoma.
Duration of frontline therapy and impact on clinical outcomes in newly diagnosed multiple myeloma patients not receiving frontline stem cell transplant
Authors: Ailawadhi Sikander , Ogbonnaya Augustina , Murty Sharanya , Cherepanov Dasha , Schroader Bridgette Kanz , Romanus Dorothy , Farrelly Eileen , Chari Ajai 
Published: September 2022

AbstractBackgroundExtended first‐line therapy (1LT) has improved clinical outcomes in newly diagnosed multiple myeloma (NDMM). This retrospective study of NDMM patients evaluated the relationship between dose‐attenuation of 1LT and duration of therapy (DOT) and DOT on outcomes.MethodsAdults with NDMM not undergoing stem cell transplant (SCT) from January 1, 2012 toMarch 31, 2018 from the Integrated Oncology Network were included; 300 were randomly selected for chart review. 1LT DOT, time to next treatment (TTNT), progression‐free survival (PFS), and overall survival (OS) were estimated using Kaplan–Meier analysis. Marginal structural models evaluated relationships between DOT and TTNT, PFS, and OS at 2 years accounting for confounders and survival bias from the time‐dependent nature of DOT.ResultsOf 300 chart‐reviewed patients, 93 were excluded for incomplete data or meeting exclusion criteria. Among 207 NDMM patients, median age was 74 years; 146 (70.5%) did not receive dose‐attenuation during 1LT. Patients with short DOT were older, frailer, with a higher comorbidity burden, and a significantly lower proportion had an Eastern Cooperative Oncology Group PS = 0. As DOT increased, more patients underwent dose‐attenuation (p < 0.0001). The median 1LT DOT was 20.9 (95% confidence interval [CI]: 13.9, 26.4) versus 4.2 months (95% CI: 3.2, 4.9) for patients receiving versus not receiving dose‐attenuation, respectively (p < 0.0001). After accounting for survival bias, confounder‐adjusted TTNT was prolonged with each additional month of 1LT (odds ratio [OR]: 0.76 [95% CI: 0.75, 0.78]); likelihoods of risks of disease progression (OR: 0.87 [95% CI: 0.86, 0.88]) and death at 2 years (OR: 0.72 [95% CI: 0.70, 0.74]) were reduced with each month of 1LT (p < 0.0001 for all outcomes).ConclusionsDose‐attenuated 1LT was associated with longer DOT among patients with non‐SCT NDMM. Each additional month of 1LT was associated with a reduced adjusted likelihood of disease progression and death at 2 years. Dose‐attenuation of 1LT can extend DOT; longer DOT may improve clinical outcomes.
Deep molecular response in patients with chronic phase chronic myeloid leukemia treated with the plasminogen activator inhibitor‐1 inhibitor TM5614 combined with a tyrosine kinase inhibitor
Authors: Takahashi Naoto , Kameoka Yoshihiro , Onizuka Makoto , Onishi Yasushi , Takahashi Fumiaki , Dan Takashi , Miyata Toshio , Ando Kiyoshi , Harigae Hideo 
Published: September 2022

AbstractBackgroundWe recently showed that pharmacological inhibition of plasminogen activator inhibitor‐1 (PAI‐1) activity, based on TM5614, increases cell motility and induces the detachment of hematopoietic stem cells from their niches. In this TM5614 phase II clinical trial, we investigated whether the combination of a PAI‐1 inhibitor and tyrosine kinase inhibitors (TKIs) would induce a deep molecular response (DMR) in patients affected by chronic myeloid leukemia (CML) by quantifying BCR‐ABL1 transcripts.MethodsPatients with chronic phase CML treated with a stable daily dose of TKIs for at least 1 year and yielding a major molecular response (MMR) but not achieving MR4.5 were eligible for this study. After inclusion, patients began to receive TM5614 as well as a TKI. The primary objective was an evaluation of the cumulative incidence of patient progression from an MMR/MR4 to MR4.5 by 12 months.ResultsThirty‐three patients were enrolled in the study. The median age was 59.0 years and 58% were male. No Sokal high‐risk patients were enrolled in this trial. The median TKI treatment duration was 4.8 years. At the start of this study, seven patients and 26 patients received imatinib and second‐generation TKIs, respectively. The cumulative MR4.5 incidence by 12 months was 33.3% (95% confidence interval, 18.0%–51.8%). The cumulative MR4.5 spontaneous conversion over 12 months was estimated as 8% with TKIs alone based on historical controls. The halving time of BCR‐ABL1 at 2 months was significantly shorter for patients who achieved an MR4.5, by 12 months than for the other patients (cutoff value: 48 days; sensitivity: 0.80; specificity: 0.91; ROC‐AUC: 0.83). During this study, bleeding events and abnormal coagulation related to the drug were not reported, and TM5614 was found to be highly safe.ConclusionTM5614 combined with TKI was well tolerated and induced MR4.5 in more patients than stand‐alone TKI treatment.
Retrospective evaluation of the role of gemcitabine‐docetaxel in well‐differentiated and dedifferentiated liposarcoma
Authors: Thirasastr Prapassorn , Lin Heather , Amini Behrang , Wang Wei‐Lien , Cloutier Jeffrey M. , Nassif Elise F. , Keung Emily Z. , Roland Christina L. , Feig Barry , Araujo Dejka , Benjamin Robert S. , Conley Anthony P. , Livingston John A. , Ludwig Joseph , Patel Shreyaskumar , Ratan Ravin , Ravi Vinod , Zarzour Maria Alejandra , Zhou Xiao , Somaiah Neeta 
Published: September 2022

AbstractObjectiveWell‐differentiated (WDLPS) and dedifferentiated liposarcoma (DDLPS) account for the majority of liposarcomas. Although gemcitabine‐docetaxel is used as second‐line treatment in soft tissue sarcomas, its efficacy in WDLPS/DDLPS is not established. This study retrospectively analyzed the efficacy of gemcitabine regimens in WDLPS/DDLPS.MethodsAll patients with WDLPS or DDLPS who received gemcitabine‐based chemotherapy at our institution between September 2002 and January 2021 were included. Response was evaluated by an independent radiologist using RECIST 1.1. The Kaplan–Meier method was used to estimate distributions of survival outcomes and log‐rank tests were used to compare survival outcomes between subgroups.ResultsSixty‐five WDLPS/DDLPS patients were included. Seven patients (10.8%) received a gemcitabine‐based regimen more than once, totaling 72 treatments. The median age at the start of treatment was 66 years (range 32–80 years). Sixty‐five (90.3%) regimens were gemcitabine‐docetaxel, and 7 (9.7%) were gemcitabine alone. Majorities of treatments were for disease that was recurrent/metastatic (86.1%), was abdominal/retroperitoneal (83.3%), and had DDLPS components (88.9%), while 25.0% of treatments were for multifocal disease. The overall response rate was 9.7% (7/72). All responses were in patients with documented DDLPS. The median time to progression was 9.2 months (95% CI 5.3–12.3 months). The median overall survival from the start of therapy was 18.8 months (95% CI 13.1–32.4 months).ConclusionGemcitabine‐docetaxel is an efficacious second‐line treatment for DDLPS. Though cross study comparisons are not advisable, response to gemcitabine‐docetaxel compares favorably to current standard options trabectedin and eribulin. This combination is a valid comparator arm for future second‐line trials in DDLPS.
A Computational Insight on the Inhibitory Potential of 8‐Hydroxydihydrosanguinarine (8‐HDS), a Pyridone Containing Analog of Sanguinarine, against SARS CoV2**
Authors: Jena Atala Bihari , Kanungo Namrata , Chainy Gagan Bihari Nityananda , Devaraji Vinod , Das Sudipta Kumar , Dandapat Jagneshwar 
Published: September 2022

AbstractThe unprecedented global pandemic of COVID‐19 has created a daunting scenario urging an immediate generation of therapeutic strategy. Interventions to curb the spread of viral infection primarily include setting targets against the virus. Here in this study we target S protein to obstruct the viral attachment and entry and also the M pro to prevent the viral replication. For this purpose, the interaction of S protein and M pro with phytocompounds, sanguinarine and eugenol, and their derivatives were studied using computational tools. Docking studies gave evidence that 8‐hydroxydihydrosanguinarine (8‐HDS), a derivative of sanguinarine, showed maximum binding affinity with both the targets. The binding energies of the ligand with S protein and M pro scored to be ΔGb −9.4 Kcal/mol and ΔGb −10.3 Kcal/mol, respectively. MD simulation studies depict that the phytocompound could effectively cause structural perturbations in the targets which would affect their functions. 8‐Hydroxydihydrosanguinarine distorts the α‐helix in the secondary structure of M pro and RBD site of S protein. Protein‐protein interaction study in presence of 8‐hydroxydihydrosanguinarine also corroborate the above findings which indicate that this polyphenol interferes in the coupling of S protein and ACE2. The alterations in protonation of M pro suggest that the protein structure undergoes significant structural changes at neutral pH. ADME property of 8‐hydroxydihydrosanguinarine indicates this could be a potential drug. This makes the phyto‐alkaloid a possible therapeutic molecule for anti COVID‐19 drug design.
49,XXXXY syndrome: A case study and a systematic review of clinical features among the Iranian population
Authors: Rajabzadeh Mahboubeh , Taheri Nafiseh , Jazayeri Omid 
Published: September 2022

AbstractThe present study describes the clinical, biochemical, hormonal, and developmental characteristics of a patient affected 49,XXXXY syndrome with routine Fraccaro syndrome features accompanied by sexual masturbation behavior. This study summarized the clinical features and also maternal age on birth time of so far 49,XXXXY reported patients among the Iranian population.
Electrochemical Capacitor Based on Reduced Graphene Oxide/NiS2 Composite
Authors: Kachmar Andrii , Tobis Maciej , Frąckowiak Elżbieta 
Published: September 2022

AbstractThe use of a pyrite‐like structure transition metal dichalcogenides (TMDs) such as NiS2 is not reported as frequently as layered structured TMDs in electrochemical capacitors. Our study shows a reduced graphene oxide (rGO) preparation and its further use as a substrate for the deposition of NiS2 during the hydrothermal reaction. The influence of pH for the GO solution on the structural and textural properties of the resultant rGO was explained in detail by using Raman spectroscopy, UV, X‐ray diffraction (XRD), scanning electron microscopy (SEM) and nitrogen sorption at 77 K. The electrochemical response of the rGO samples obtained from various pH solutions was studied and compared in symmetric two electrode Swagelok® cells. As a result, rGO pH 12 was chosen for further modification with NiS2. The average size of the crystallites, and electronic structure of the rGO/NiS2 composite have been determined. The effect of the NiS2 content in the composite on the electrochemical results was further investigated. It occurred that 5 wt % NiS2 in the composite was sufficient for a significant improvement of the capacitive response. Interestingly, an asymmetric cell with rGO/5 wt % NiS2 working as a positive electrode and rGO pH 12 as a negative electrode was able to reach a high capacitance of 165 F g−1 at 0.2 A g−1 with 92 % coulombic and 79 % energetic efficiency.
A Study of Cu‐Rh Electrodeposition**
Authors: Anastasiadou Dimitra , Janssen Jasmijn T. D. , Hensen Emiel J. M. , Figueiredo Marta Costa 
Published: September 2022

AbstractThis manuscript reports the simultaneous electrodeposition of Cu and Rh from an aqueous nitrate solution. The early stages of nucleation and growth of the bimetallic layer were explored using techniques such as cyclic voltammetry and current transients. Non‐dimensional Scharifker‐Hills graphs showed the occurrence of diffusion‐controlled three‐dimensional nucleation and growth best described by the Volmer‐Weber mechanism. Additionally, different ratios of Cu−Rh electrodes were synthesized by varying the potential of deposition and the Rh content in the deposition bath. Characterization techniques including electron microscopy, x‐ray diffraction, and x‐ray photoelectron spectroscopy were employed to investigate the chemical composition and structure of the deposits. The results showed a higher amount of Cu2+species in the layer than Cu+/Cu0when a more negative potential was applied, and when Rh was present in high amounts in the deposition bath. The final morphology of the obtained material proved to be dependent on the deposition potentials and the Cu : Rh content, showing interdependency between the metals.
Metal Nodes of Metal‐Organic Frameworks can Activate Molecular Hydrogen
Authors: Melillo Arianna , Franconetti Antonio , Alvaro Mercedes , Ferrer Belen , Garcia Hermenegildo 
Published: September 2022

AbstractHydrogenation of multiple bonds are among the most general and important organic reactions. Typical heterogeneous catalysts are based on transition metal nanoparticles, including noble metals. Data are presented here showing that metal nodes of MIL‐101(Cr) and UiO‐66 in the absence of occluded metal nanoparticles can promote hydrogenation of polarized X=Y double bonds of nitro and carbonyl groups. The catalytic activity is a function of the composition of the metal node and the organic linker. It is proposed that the reaction mechanism is based on the operation of frustrated Lewis acid/base pairs.