bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimicrobial Stewardship Programs in PICU Settings: A Systematic Review
Authors: Chorafa Elisavet , Komatsiouli Vasiliki , Iosifidis Elias , Kourti Maria , Sdougka Maria , Roilides Emmanuel 
Published: August 2022

OBJECTIVES:
Development of antimicrobial stewardship programs (ASPs) is strategy for prevention and management of emergence of antimicrobial-resistant organisms. In this study, we systematically reviewed the literature on antimicrobial stewardship interventions in PICUs and analyzed approaches, structure, implementation, and outcomes of the ASPs.

DATA SOURCES:
PubMed and Scopus databases were systematically searched for studies published from January 1, 2007, to December 31, 2020, reporting interventions on judicious use of antimicrobials in PICUs (last search performed February 28, 2021).

DATA SELECTION:
Studies that evaluated an intervention in a PICU setting or both in PICU and other settings and reported separate results for PICU were eligible for full-text review. Studies that had implemented stewardship in the entire hospital, including the PICU, but without presenting dedicated PICU data were excluded from the analysis.

DATA EXTRACTION:
The strategy of intervention, structure of ASP team, implementation, and outcomes were assessed with a checklist tool for all studies included in the analysis. Risk of bias was assessed with the Cochrane Risk-of-Bias in Nonrandomized studies of Interventions tool.

DATA SYNTHESIS:
Thirteen articles were found: 11 that applied ASP in PICUs, and two at hospital level. All PICU-dedicated ASPs applied a multimodal intervention combining strategies simultaneously; audit with feedback (6/11) and facility-specific clinical practice guidelines (7/11) were the most common strategies. A multidisciplinary team was formulated in all ASPs except for three biomarker-based interventions. Six of 11 studies included techniques to enhance behavior change and one implemented a behavior-based intervention. Antibiotic consumption was evaluated in all ASPs, cost in three of 11, antibiotic resistance in one of 11, length of hospitalization in six of 11, and mortality in eight of 11. All hospital-wide ASPs used audit with feedback in addition to facility-specific clinical practice guidelines and assessed antimicrobial consumption, expenditures, length of stay, and mortality.

CONCLUSIONS:
The prevalence of ASPs in PICUs is limited, and few programs follow all of the currently available recommendations.
Haplotype mining panel for genetic dissection and breeding inEucalyptus
Authors: Candotti Julia , Christie Nanette , Ployet Raphael , Mostert-O’Neill Marja M. , Reynolds S. Melissa , Neves Leandro Gomide , Naidoo Sanushka , Mizrachi Eshchar , Duong Tuan A. , Myburg Alexander A. 
Published: August 2022

SummaryTo improve our understanding of genetic mechanisms underlying complex traits in plants, a comprehensive analysis of gene variants is required.Eucalyptusis an important forest plantation genus that is highly outbred. Trait dissection and molecular breeding in eucalypts currently relies on biallelic SNP markers. These markers fail to capture the large amount of haplotype diversity in these species and thus multi-allelic markers are required. We aimed to develop a gene-based haplotype mining panel forEucalyptusspecies. We generated 17 999 oligonucleotide probe sets for targeted sequencing of selected regions of 6 293 genes implicated in growth and wood properties, pest and disease resistance and abiotic stress responses. We identified and phased 195 834 SNPs using a read-based phasing approach to reveal SNP-based haplotypes. A total of 8 915 target regions (at 4 637 gene loci) passed tests for Mendelian inheritance. We evaluated the haplotype panel in fourEucalyptusspecies (E. grandis,E. urophylla,E. dunniiandE. nitens) to determine its ability to capture diversity across eucalypt species. This revealed an average of 3.13 to 4.52 haplotypes per target region in each species and 33.36% of the identified haplotypes were shared by at least two species. This haplotype mining panel will enable the analysis of haplotype diversity within and between species and provide multi-allelic markers that can be used for genome-wide association studies and gene-based breeding approaches.Significance StatementWe developed a haplotype sequencing panel forEucalyptustargeting 8915 regions at 4637 gene loci associated with growth and wood properties, pest and disease resistance and abiotic stress response providing a genome-wide, multi-allelic, gene centric genotyping resource for eucalypts. We tested the panel in fourEucalyptusspecies (E. grandis,E. dunnii,E. nitensandE. urophylla) and found an average of 3.65 haplotypes per target region per species, and 9.98 across all four species.
Operation of Carbon-Concentrating Mechanisms in Cyanobacteria and Algae requires altered poising of the Calvin-Benson cycle
Authors: Treves Haim , Lucius Stefan , Feil Regina , Stitt Mark , Hagemann Martin , Arrivault Stéphanie 
Published: August 2022

AbstractCyanobacteria and eukaryotic algae make a major contribution to global photosynthetic productivity. To cope with the low availability of CO2 in aqueous systems they deploy inorganic carbon-concentrating mechanisms (CCMs). These concentrate CO2 in microcompartments that contain Rubisco (carboxysomes in cyanobacteria; pyrenoids in green algae). The rest of the Calvin-Benson cycle (CBC) is located outside these microcompartments. We hypothesized that this physical separation requires modified poising of the CBC. Hence, Rubisco is physically separated from the other CBC enzymes outside these microcompartments. To test the hypothesis that this physical separation requires appropriate poising of the CBC, we profiled CBC metabolites under ambient CO2 in the cyanobacterium Synechocystis sp. PCC 6803 and three eukaryotic algae (Chlamydomonas reinhardtii, Chlorella sorokiniana, Chlorella ohadii). Comparison with recently reported profiles for a large set of terrestrial plants revealed that cyanobacteria and green algae have very distinctive CBC metabolite profiles, with low levels of pentose phosphates and, especially, high levels of ribulose 1,5-bisphosphate and 3-phosphoglycerate. We propose that large pools of the substrate and product of Rubisco are required to generate concentration gradients that drive movement into and out of the microcompartments. These observations raise questions about how CBC regulation was modified during the evolution of algal CCMs and their subsequent loss in terrestrial plants, and highlight that operation of CCMs requires co-evolution of the CBC.HighlightCBC metabolite profiles in the cyanobacterium Synechocystis and in three eukaryotic green algae at ambient CO2 concentration are very different to those in terrestrial plants, probably reflecting the operation of a carboxysome- or pyrenoid-based carbon concentrating mechanism.
Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase
Authors: Koudelková Lenka , Brůhová Zuzana , Sztacho Martin , Pavlík Vojtěch , Pánek Dalibor , Gemperle Jakub , Brábek Jan , Rösel Daniel 
Published: August 2022

ABSTRACTThe activation of Src kinase in cells is strictly controlled by intramolecular inhibitory interactions mediated by SH3 and SH2 domains. They impose structural constraints on the kinase domain holding it in a catalytically non-permissive state. The transition between inactive and active conformation is known to be largely regulated by the phosphorylation state of key tyrosines 416 and 527. Here we identified that phosphorylation of tyrosine 90 reduces binding affinity of the SH3 domain to its interacting partners, opens the Src structure, and renders Src catalytically active. This is accompanied by an increased affinity to the plasma membrane, decreased membrane motility and slower diffusion from focal adhesions. Phosphorylation of tyrosine 90 controlling SH3-medited intramolecular inhibitory interaction, analogical to tyrosine 527 regulating SH2-C-terminus bond, enables SH3 and SH2 domains to serve as cooperative but independent regulatory elements. This mechanism allows Src to adopt several distinct conformations of varying catalytic activities and interacting properties, enabling it to operate not as a simple switch but as a tunable regulator functioning as a signaling hub in a variety of cellular processes.
Virtual mentoring and coaching for school leaders participating in virtual professional learning communities
Authors: Irby Beverly J. , Pashmforoosh Roya , Tong Fuhui , Lara-Alecio Rafael , Etchells Matthew J. , Rodriguez Linda , Prickett Christopher , Zhao Yingying 
Published: August 2022

PurposeThis study was conducted in the United States of America to identify what practices virtual mentor-coaches perceived to be effective in virtual mentoring and coaching (VMC) within virtual professional learning communities (VPLCs). The authors also sought to determine the ways in which virtual mentor-coaches provided VMC for school leaders within VPLCs.Design/methodology/approachThe authors used a phenomenological approach in our research, describing the lived experiences of practicing virtual mentor-coaches as they engaged in VMC. Data analysis included video analysis and systematic coding of interview data.FindingsAn in-depth analysis of interview and video data showed that virtual mentor-coaches support school leaders in developing and transforming school leaders' leadership for building teachers' instructional capacity. The authors identified a VMC process model within VPLCs, including four steps as follows: (1) presentation, (2) collaboration, (3) reflection and (4) action plan.Practical implicationsVMC for school leaders participating in VPLCs is regarded as a transformative model which provides encouragement, reflection and support for instructional leadership actions.Originality/valueKey steps and components of an effective VMC highlighted in the current research offer practical guidance for future virtual mentor-coaches in conducting and implementing VMC within VPLCs.
Strengthened rule of law to reduce corruption: evidence from Asia-Pacific countries
Authors: Mohd-Rashid Rasidah , Mehmood Waqas , Ooi Chai-Aun , Che Man Siti Zakiah , Ong Chui Zi 
Published: August 2022

Purpose
Rule of law is essential in reducing corruption in a country. This study aims to investigate the factors contributing to corruption in 41 of the most competitive countries in the Asia-Pacific region by focusing on judicial effectiveness, property rights and government integrity. The moderating role of regulatory quality was also considered in the attempt to explain the association among rule of law and corruption.

Design/methodology/approach
This study used pooled ordinary least squares regression and generalized method of moments-dynamic panel for the robustness test on data of 41 Asia-Pacific countries spanning from 2013 to 2021.

Findings
Property rights and government integrity were found to be negatively significant in explaining corruption. In contrast, the interaction between rule of law and regulatory quality had a significant positive association with corruption. The findings bring to light Asia-Pacific countries’ need for more effective control of corruption.

Practical implications
The authorities should work towards enhancing the countries’ image as corruption-free nations by creating a stable economic and political environment and preserving macroeconomic stability through strengthened rule of law.

Originality/value
Previous research looked at The Association of Southeast Asian Nations and South Asian countries, but little attention was given to Asia-Pacific countries in examining the relationship between rule of law and corruption.
Relationship coordination between successor and top management team in family business under the background of social embeddedness: a case study of trans-generational entrepreneurship
Authors: Wang Fei Fei , Wu Jiong , Gong Xiaoxian 
Published: August 2022

PurposeAiming at the key issue of interpersonal interaction process between successors and top management teams in the context of family business trans-generational entrepreneurship, this paper aims to explore the motivation, action and results of interpersonal conflict between these two subjects mentioned above.Design/methodology/approachThis paper uses grounded theoretical research methods based on the research objects of three family businesses with both inheritance and transformation needs.FindingsMotivation difference, mediation mode and relationship utilization, that is, the successor and top management team take the goal-orientation, interest orientation and rational tendency as the starting point for relationship coordination. Then it mediates the interpersonal conflicts through compromise, collaboration and compliance, and ultimately provide successors with resources, opportunities, capabilities and motivation advantages to promote trans-generational entrepreneurship. Second, the path of relationship coordination comes from the background of social embedding, that is, the motivation difference comes from the embedding of motivation seeking, the mediation mode comes from the embedding of mediation elements and the relationship utilization comes from the embedding of relationship optimization. The research conclusions not only provide a theoretical framework for family businesses to solve the problems of interpersonal conflicts faced by family businesses but also have practical guiding significance for the trans-generational entrepreneurship.Originality/valueThere are two theoretical contributions in this study. First, the research starting point of social embeddedness theory from the perspective of interpersonal relationships at the microlevel is revised. Since Granovetter (Granovetter, 1985) put forward the theory of social embeddedness, its research scope has been gradually expanded, but the mainstream research in the past focused on analyzing the social network embeddedness of enterprises to obtain social capital from the macro- and meso-level (Nahapiet and Ghoshal, 1998). In fact, this may deviate from the essential interpretation of Granovetter’s theory of social embeddedness, while this study returns to the study of interpersonal relationships. Second, a theoretical model of relationship coordination for successors and top management team is put forward in general. On the basis of the motivation, action and result of interpersonal interaction between the successor and top management team, the interpersonal coordination action path and embedded logic during trans-generational entrepreneurship of family businesses are revealed, which enriched the research scope of social embedded theory in family business.
Can individualism/collectivism paradigm explain disparate roles for intermediaries in an organizational justice model of police compliance with agency rules?
Authors: Peacock Robert Patrick , Kutnjak Ivkovich Sanja , Wu Yuning , Sun Ivan , Pavlović Vinogradac Valentina , Vinogradac Marijan 
Published: August 2022

PurposeThis paper examines whether dissimilarities in societal cultures impact the path by which a key component of organizational culture—supervisory procedural justice (SPJ)—influences police officer compliance with police agency rules.Design/methodology/approachThe study utilized structural equation modeling across a data set of 1,189 Croatian and Taiwan police officers to test whether a societal value (individualism/collectivism) impacts the role of three intermediary variables (trust in the public, job satisfaction and pro-organization initiative) in a procedural justice model of officer compliance with the rules.FindingsThe study found that, despite a strong statistical similarity in the individual attitudes of Croatian and Taiwan police officers, the intermediary variables in the model significantly differed between the two countries. Most notably, the role of trust in the public and pro-organization initiative supported past research suggesting that collectivist versus individualistic societal cultures lead to divergent organizational attitudes and policing outcomes.Originality/valueThis is the first empirical study to compare the impact of societal values on a model of SPJ on officer compliance with agency rules.
Glomerular cell cross talk in diabetic kidney diseases
Authors: Dong Ruixue , Xu Youhua 
Published: August 2022

AbstractDiabetic kidney disease (DKD) is a severe microvascular complication of diabetes mellitus. It is the leading inducement of end‐stage renal disease (ESRD), and its global incidence has been increasing at an alarming rate. The strict control of blood pressure and blood glucose can delay the progression of DKD, but intensive treatment is challenging to maintain. Studies to date have failed to find a complete cure. The glomerulus's alterations and injuries play a pivotal role in the initiation and development of DKD. A wealth of data indicates that the interdependent relationship between resident cells in the glomerulus will provide clues to the mechanism of DKD and new ways for therapeutic intervention. This review summarizes the significant findings of glomerular cell cross talk in DKD, focusing on cellular signaling pathways, regulators, and potential novel avenues for treating progressive DKD.
Ageing in place and loneliness of older adults in Shanghai, China
Authors: Yang Fang , Wang Huiguang , Wu Qi , Gao Yourong 
Published: August 2022

AbstractObjectiveThis study examined loneliness experiences of older adults and the relationship between ageing in place and their loneliness from the social resources perspective of social capital in Shanghai, China.MethodsWe used the purposive sampling method and conducted face‐to‐face individual interviews for 21 older adults who were widowed or living alone. A semi‐structured interview was carried out based on a pilot‐tested interview guide, and the interviews were audio recorded and transcribed verbatim.ResultsOlder adults expressed a feeling of ‘lonely pain’, and themes identified included lack of intimacy and companionship, fear of declining health, loss and death, and a sense of disconnection from the external world. In the context of ageing in place, they mobilised the social capital embedded in the community to cope with loneliness by obtaining support, participating in activities and experiencing the trust and reciprocity that results from social networks. However, inadequate ageing in place services cannot fully alleviate the risk of loneliness for older adults, especially for those who are widowed or living alone.ConclusionsThe social capital embedded in the context of ageing in place in Shanghai partially helps older adults deal with loneliness, and future ageing in place policy and services should be improved to make older adults who wish to stay at home or in a familiar community live safely, autonomously and not feel lonely.
Synoptic CT scan reporting of pancreatic adenocarcinoma to align with international consensus guidelines on surgical resectability: a Victorian pilot
Authors: Pilgrim Charles H. C. , Maciejewska Anna , Ayres Nadia , Ellis Sam , Goodwin Mark , Zalcberg John R. , Haydon Andrew 
Published: August 2022

AbstractBackgroundNon‐metastatic pancreatic ductal adenocarcinoma (PDAC) is classified as resectable (R), borderline resectable (BR) or locally advanced (LA). International Consensus Guidelines on these definitions exist, but have not been integrated into everyday Australian practice. The anatomical features on CT imaging lend themselves to synoptic reporting which should enhance completeness, comparability and consistency.MethodsWe developed and tested a synoptic report for PDAC derived from the International Consensus Guidelines at two metropolitan pancreatic cancer services to standardize CT reporting in the region. Consecutive scans with suspected PDAC discussed at multidisciplinary meetings were reported using the template between October 2020 and September 2021. A purpose‐built database captured data regarding resectability and image‐quality parameters.ResultsNinety‐five scans were reviewed, 57.9% (N = 55) of which conformed to high‐quality pancreatic CT protocols. Of suboptimal scans, meaningful synoptic reports were able to be issued for a further 24/40 (due to metastases in 9, and unequivocal resectability status in 15). Of 79 classifiable scans, 20% were metastatic, 51% deemed resectable, 16% locally advanced and 13% borderline resectable.DiscussionPDAC lends itself to synoptic reporting given the specific anatomical considerations that classify resectability. This relies, however, on high‐quality CT imaging and it was surprising that over 40% of scans reviewed were of suboptimal quality. Despite this, resectability status according to the International Consensus Guidelines was designated for 83% of scans. Optimal treatment algorithms for LA, BR and resectable disease vary widely underscoring the critical importance of accurately differentiating these anatomic subtypes of PDAC, and thus support further implementation of a synoptic report of this nature.
The link between nascent entrepreneurs' role identity aspirations and their opportunity exploration and exploitation activities
Authors: Roelandt Jolien , Rijssegem Laurence , Andries Petra 
Published: August 2022

AbstractAlthough nascent entrepreneurs' opportunity exploration and exploitation activities are crucial for later venture evolution and performance, it is unclear why some nascent entrepreneurs engage more in these new venture creation activities than others. Building upon role identity theory, this study advances a nascent entrepreneur's various role identity aspirations as drivers of these activities. In particular, we argue that inventor, founder, and developer role identity aspirations are linked differently to the range of opportunity exploration and exploitation activities nascent entrepreneurs undertake.We use a two‐stage Poisson model with sample selection correction on a random sample of 1582 inhabitants of Flanders, Belgium. The first stage estimates an individual's probability to engage in nascent entrepreneurship. The second stage tests the relationships between an individual's role identity aspirations and the range of exploration and exploitation activities undertaken, conditional on being a nascent entrepreneur, which holds for 162 individuals in our sample. We find that while some role identity aspirations are related to the range of opportunity exploration activities undertaken, others primarily affect the range of exploitation activities. Our findings have important implications for literature on new venture creation and entrepreneurial opportunities, for identity literature, and for nascent entrepreneurs wanting to start a venture.