bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of advanced endoscopic technology for optical characterization of neoplasia in patients with ulcerative colitis: Systematic review
Authors: Maeda Yasuharu , Kudo Shin‐ei , Ogata Noriyuki , Kuroki Takanori , Takashina Yuki , Takishima Kazumi , Ogawa Yushi , Ichimasa Katsuro , Mori Yuichi , Kudo Toyoki , Hayashi Takemasa , Miyachi Hideyuki , Ishida Fumio , Nemoto Tetsuo , Ohtsuka Kazuo , Misawa Masashi 
Published: April 2022

ObjectivesAdvances in endoscopic technology, including magnifying and image‐enhanced techniques, have been attracting increasing attention for the optical characterization of colorectal lesions. These techniques are being implemented into clinical practice as cost‐effective and real‐time approaches. Additionally, with the recent progress in endoscopic interventions, endoscopic resection is gaining acceptance as a treatment option in patients with ulcerative colitis (UC). Therefore, accurate preoperative characterization of lesions is now required. However, lesion characterization in patients with UC may be difficult because UC is often affected by inflammation, and it may be characterized by a distinct “bottom‐up” growth pattern, and even expert endoscopists have relatively little experience with such cases. In this systematic review, we assessed the current status and limitations of the use of optical characterization of lesions in patients with UC.MethodsA literature search of online databases (MEDLINE via PubMed and CENTRAL via the Cochrane Library) was performed from 1 January 2000 to 30 November 2021.ResultsThe database search initially identified 748 unique articles. Finally, 25 studies were included in the systematic review: 23 focused on differentiation of neoplasia from non‐neoplasia, one focused on differentiation of UC‐associated neoplasia from sporadic neoplasia, and one focused on differentiation of low‐grade dysplasia from high‐grade dysplasia and cancer.ConclusionsOptical characterization of neoplasia in patients with UC, even using advanced endoscopic technology, is still challenging and several issues remain to be addressed. We believe that the information revealed in this review will encourage researchers to commit to the improvement of optical diagnostics for UC‐associated lesions.
A giant right atrial appendage aneurysm in an infant: A case report
Authors: Yue Jianming , Wang Qi , Liu Bin , Zhou Leng 
Published: April 2022

AbstractRight atrial appendage aneurysms (RAAAs) are extremely rare in cardiac anomalies. According to the literature, a few dozen cases have been reported thus far, among which only four cases were infants or neonates. Here, we report an infant with a giant RAAA and severe symptoms. The RAAA was diagnosed by echocardiography and surgically resected under cardiopulmonary bypass (CPB). The role of transesophageal echocardiography was very important during aneurysm resection surgery, which helped surgeons to plan surgical procedures during surgery and evaluate the surgical effect postoperatively.
Diet‐mediated immune response to parasitoid attacks on a caterpillar with a broad diet breadth
Authors: Vyas Dhaval K. , Murphy Shannon M. 
Published: April 2022

Abstract
Bottom‐up (plant) and top‐down (natural enemy) trophic factors can interact to have significant influence on the diet breadth of herbivores. For herbivorous insects that are victim to parasitoid attacks, diet composition can modulate insect immune responses against the parasitoid. However, immune responses are costly and insect herbivores experience a trade‐off between investment in immune defences and other physiological processes.
We used a split‐brood laboratory experiment to explore how the diet of the fall webworm (Hyphantria cunea), a species that eats over 400 plant species, affects larval growth and fitness and cellular immune response to attacks from a parasitic wasp. We reared larvae on four different plant diets (apple, alder, chokecherry, cottonwood) and then exposed them to an immune challenge from a parasitoid attack.
We found that diet influenced larval development as well as parameters indicative of immune response. Larvae reared on the plant that led to the poorest development also had the fewest granulocytes and the highest odds of containing a parasitoid larva. However, larval growth was not a predictor of immune response.
Overall, we show that the bottom‐up effect of diet variability has significant impacts on insect immune response such that larval fitness varies considerably when fed different dietary plant species. Broad diet ranges may offer herbivorous insects the opportunity to exploit a different set of resources depending on the severity of top‐down pressures. Here, we show that this variability in plant quality also has significant impacts on larval immune response.
The spectrum and frequency of histopathological diagnosis of oral diseases in Oslo: Implications to oral pathology syllabus
Authors: Sofizadeh Narmin , Bjerkehagen Bodil , Solheim Tore , Sapkota Dipak , Søland Tine M. 
Published: April 2022

AbstractIntroductionTo assure knowledge and skills in diagnostic work of oral diseases a continuously updated curriculum is essential. The first aim of the present study was to evaluate the spectrum and frequency of oral histopathological diagnoses signed out by oral pathologists at the Department of Pathology, Oslo University Hospital (OUS), Norway during a two‐year period. The second aim was to compare the spectrum of histopathological diagnoses with the content of the current syllabus in oral pathology at the Faculty of Dentistry, University of Oslo (UiO).Materials and MethodsIn this retrospective cross‐sectional study, all histological diagnosis signed out during 2015 and 2016 were included. All histopathological reports were analysed with regard to clinical information and histopathological diagnosis. The spectrum of histopathological diagnoses was compared to the diagnoses presented in lectures and courses for dental and dental hygienist students at UiO.ResultsThree thousand four hundred and two histopathological reports (47% males and 53% females) were included. The diagnoses were categorised into eight disease groups and the three most frequent disease groups were cysts, benign tumours/reactive lesions, and white, red, ulcerative and vesiculobullous lesions. The lateral periodontal cyst was more frequent than expected.ConclusionsWe conclude that a minor revision of the syllabus is needed, although the most frequent oral conditions presented in this study are well covered in the oral pathology teaching in Oslo. A more clinical related teaching approach should be considered by categorising oral diseases according to, for example location and age groups.
5‐HT2 receptor antagonism reduces human motoneuron output to antidromic activation but not to stimulation of corticospinal axons
Authors: Thorstensen Jacob R. , Taylor Janet L. , Kavanagh Justin J. 
Published: April 2022

AbstractThe intrinsic electrical properties of motoneurons strongly affect motoneuron excitability to fast‐acting excitatory ionotropic inputs. Serotonin (5‐HT) is a neurochemical that alters the intrinsic properties of motoneurons, whereby animal models and in vitro experiments indicate that 5‐HT increases motoneuron excitability by activating 5‐HT2 receptors on the somato‐dendritic compartment. In the current study, we examined how antagonism of the 5‐HT2 receptor affects motoneuron excitability in humans. We hypothesised that motoneuron excitability would be reduced. The 5‐HT2 antagonist cyproheptadine was administered to 10 healthy participants in a double‐blinded, placebo‐controlled, crossover trial. Electrical cervicomedullary stimulation was used to deliver a synchronised excitatory volley to motoneurons to elicit cervicomedullary motor evoked potentials (CMEPs) in the surface electromyography (EMG) signal of the resting biceps brachii. Likewise, electrical peripheral nerve stimulation was used to generate antidromic spikes in motoneurons and cause recurrent discharges, which were recorded with surface EMG as F‐waves in a resting hand muscle. Compared with placebo, we found that 5‐HT2 antagonism reduced the amplitude and persistence of F‐waves but did not affect CMEP amplitude. 5‐HT2 antagonism also reduced maximal contraction strength. The reduced recurrent discharge of motoneurons with 5‐HT2 antagonism suggests that 5‐HT2 receptors modulate the electrical properties of the initial segment or soma to promote excitability. Conversely, as cyproheptadine did not affect motoneuron excitability to brief synaptic input, but affected maximal contractions requiring sustained input, it seems likely that the 5‐HT2‐mediated amplification of synaptic input at motoneuron dendrites is functionally significant only when excitatory input activates persistent inward currents.
Genomic consequences of a century of inbreeding and isolation in the Danish wild boar population
Authors: Yıldız Beril , Megens Hendrik‐Jan , Hvilsom Christina , Bosse Mirte 
Published: April 2022

AbstractDemographic events such as series of bottlenecks impact the genetic variation and adaptive potential of populations. European megafauna, such as wild boars (Sus scrofa), have experienced severe climatic and size fluctuations that have shaped their genetic variation. Habitat fragmentation and human‐mediated translocations have further contributed to the complex demographic history of European wild boar. Danish wild boars represent an extreme case of a small and isolated population founded by four wild boars from Germany. Here, we explore the genetic composition of the Danish wild boar population in Klelund. We genotyped all 21 Danish wild boars that were recently transferred from the source population in Lille Vildmose into the Klelund Plantation to establish a novel wild boar population. We compared the Danish wild boars with high‐density single‐nucleotide polymorphism genotypes from a comprehensive reference set of 1263 wild and domesticated pigs, including 11 individuals from Ulm, one of two presumed founder locations in Germany. Our findings support the European wild background of the Danish population, and no traces of gene flow with wild or domesticated pigs were found. The narrow genetic origin of the Danish wild boars is illustrated by extremely long and frequent runs of homozygous stretches in their genomes, indicative of recent inbreeding. This study provides the first insights into one of the most inbred wild boar populations globally established a century ago from a narrow base of only four founders.
Building a classroom discourse community in university Spanish courses: What high‐achieving language teachers do
Authors: Borden Rebecca 
Published: April 2022

AbstractThe purpose of this mixed‐methods study was to uncover how high‐achieving university Spanish instructors engage in the core practice of building a classroom discourse community at a doctoral‐level university in the southwestern United States. The second goal of this study was to determine whether student performance on reading and writing assessments was impacted by a focus on oral communication. Findings indicated that high‐achieving university Spanish instructors employed the use of personalized contexts for interaction and purposefully conceptualized planning and enacting of communicative tasks, although specific approaches in creating a classroom discourse community varied by the instructor. Despite the focus on oral communication in the participants' classes, student performance in courses taught by high‐achieving instructors was significantly higher in reading and writing assessments than the performance of students in courses taught by other instructors in the same course and language program. Findings support the notion that high‐leverage teaching practices have a palpable, practical impact on student learning.
Ecological and social strategies for managing fisheries using the Resist‐Accept‐Direct (RAD) framework
Authors: Lynch Abigail J. , Rahel Frank J. , Limpinsel Doug , Sethi Suresh A. , Engman Augustin C. , Lawrence David J. , Mills Katherine E. , Morrison Wendy , Peterson Jay O. , Porath Mark T. 
Published: April 2022

AbstractFisheries management is a complex task made even more challenging by rapid and unprecedented socioecological transformations associated with climate change. The Resist‐Accept‐Direct (RAD) framework can be a useful tool to support fisheries management in facing the high uncertainty and variability associated with aquatic ecosystem transformations. Here, RAD strategies are presented to address ecological goals for aquatic ecosystems and social goals for fisheries. These strategies are mapped on a controllability matrix which explores the ability to guide a system's behaviour towards a desired state based on ecological responsiveness and societal receptivity to change. Understanding and improving the controllability of aquatic systems and fisheries can help managers to maintain the broadest suite of available RAD management strategies.
Pathophysiology and management of bleeding and thrombosis in patients with liver disease
Authors: van den Boom Bente P. , Lisman Ton 
Published: April 2022

AbstractPatients with liver disease often develop complex changes in their haemostatic system. Frequently observed changes include thrombocytopaenia and altered plasma levels of most of the proteins involved in haemostasis. Although liver disease was historically classified as a haemostasis‐related bleeding disorder, it has now been well established that the antihaemostatic changes that promote bleeding are compensated for by prohaemostatic changes. Conventional coagulation tests however do not accurately reflect these prohaemostatic changes, resulting in an underestimation of haemostatic potential. Novel coagulation tests, such as viscoelastic tests (VETs) and thrombin generation assays (TGAs) better reflect the net result of the haemostatic changes in patients with liver disease, and demonstrate a new, “rebalanced” haemostatic status. Although rebalanced, this haemostatic status is more fragile than in patients without liver disease. Patients with liver disease are therefore not only at risk of bleeding but also at risk of thrombosis. Notably, however, many haemostatic complications in liver disease are not related to the haemostatic failure. It is, therefore, crucial to identify the cause of the bleed or thrombotic complication in order to provide adequate treatment. In this paper, we will elaborate on the haemostatic changes that occur in liver disease, reflect on laboratory and clinical studies over the last few years, and explore the pathophysiologies of bleeding and thrombosis in this specific patient group.
Understanding vaccine‐induced thrombotic thrombocytopenia (VITT)
Authors: Dix Caroline , McFadyen James , Huang Angela , Chunilal Sanjeev , Chen Vivien , Tran Huyen 
Published: April 2022

AbstractVaccine‐induced thrombotic thrombocytopenia (VITT) is a rare, but serious, syndrome characterised by thrombocytopenia, thrombosis, a markedly raised D‐dimer and the presence of anti‐platelet factor‐4 (PF4) antibodies following COVID‐19 adenovirus vector vaccination. VITT occurs at a rate of approximately 2 per 100 000 first‐dose vaccinations and appears exceedingly rare following second doses. Our current understanding of VITT pathogenesis is based on the observations that patients with VITT have antibodies that bind to PF4 and have the ability to form immune complexes that induce potent platelet activation. However, the precise mechanisms that lead to pathogenic VITT antibody development remain a source of active investigation. Thrombosis in VITT can manifest in any vascular bed and affect multiple sites simultaneously. While there is a predilection for splanchnic and cerebral venous sinus thrombosis, VITT also commonly presents with deep vein thrombosis and pulmonary embolism. Pillars of management include anticoagulation with a non‐heparin anticoagulant, intravenous immunoglobulin and ‘rescue’ therapies, such as plasma exchange for severe cases. VITT can be associated with a high mortality rate and significant morbidity, but awareness and optimal therapy have significantly improved outcomes in Australia. A number of questions remain unanswered, including why VITT is so rare, reasons for the predilection for thrombosis in unusual sites, how long pathological antibodies persist, and the optimal duration of anticoagulation. This review will provide an overview of the presentation, diagnostic workup and management strategies for patients with VITT.
Validating nature relatedness scale in the Philippines: Social responsibility as a cultural driver on why nature relatedness promotes green purchase intention
Authors: Aruta John Jamir Benzon R. , Pakingan Karmia A. 
Published: April 2022

AbstractDespite the global nature of environmental problems, research on environmental psychology has been mainly based on Western countries, and very limited studies looked into environmental psychological constructs and processes through a non‐Western cultural lens. The present study examined the psychometric properties of the short‐form Nature Relatedness Scale (NR‐6) and investigated culturally relevant mechanisms that facilitate the positive influence of nature relatedness on green purchase intentions among Filipinos. Two studies were conducted to attain these objectives. Study 1 (N = 504) validated the NR‐6. Confirmatory factor analysis yielded a stable unidimensional factor structure of NR‐6 with good data‐model fit and strong factor loadings. Study 2 (N = 366) tested a moderated mediation model indicating the mediating role of social responsibility on nature relatedness and green purchase intention relationship across the different levels of interdependent self‐construal. Results indicated that social responsibility mediated the positive impact of nature relatedness on the intention to buy green products among Filipinos. More importantly, results showed a significant moderating role of interdependent self‐construal such that the indirect effect of social responsibility was stronger among Filipinos with higher levels of self‐construal than those with lower levels. Implications, limitations, and future directions are discussed.
A meta‐analysis showing the effect of surgical site wound infections and associated risk factors in neonatal surgeries
Authors: Abdelgawad Mohamed A. , Parambi Della G.T. , Ghoneim Mohammed M. , Alotaibi Nasser Hadal , Alzarea Abdulaziz Ibrahim , Alanazi Abdullah S. , Hassan Ahmed , Tony Sara M. , Abdelrahim Mohamed EA 
Published: April 2022

AbstractA meta‐analysis was performed to assess the effect of surgical site wound infections and risk factors in neonates undergoing surgery. A systematic literature search up to January 2022 incorporated 17 trials involving 645 neonates who underwent surgery at the beginning of the trial; 198 of them had surgical site wound infections, and 447 were control for neonates. The statistical tools like the dichotomous or continuous method used within a random or fixed‐influence model to establish the odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CIs) to evaluate the risk factors and influence of surgical site wound infections in neonates undergoing surgery. Surgical site wound infections had significantly higher mortality with OR value 2.03 at 95% CI 1.40–2.95 with P‐value <0.001, the longer length of hospital stay (MD, 31.88; 95% CI, 18.17–45.59, P < 0.001), and lower birthweight of neonates (MD, −0.30; 95% CI, −0.53 to −0.07, P = 0.01) compared with neonates with no surgical site wound infections undergoing surgery. However, no remarkable change was observed with surgical site wound infections in the gestational age at birth of neonates (MD, −0.70; 95% CI, −1.46 to 0.05, P = 0.07), and the preoperative antibiotic prophylaxis (OR, 1.28; 95% CI, 0.57–2.87, P = 0.55) compared with no surgical site wound infections for neonates undergoing surgery. Surgical site wound infections had significantly higher mortality, a longer length of hospital stay, and lower birthweight of neonates. However, they had no statistically significant difference in the gestational age at birth of neonates and the preoperative antibiotic prophylaxis compared with no surgical site wound infections for neonates undergoing surgery. Furthermore, evidence is needed to confirm the outcomes.
Soil drought duration and severity affect cotton boll biomass by altering recovery times and carbon dynamics of subtending leaf
Authors: Zou Jie , Snider John L. , Zhu Honghai , He Jiaqi , Li Yuxia , Zhou Zhiguo , Wang Youhua , Meng Yali , Chen Binglin , Zhao Wenqing , Wang Shanshan , Hu Wei 
Published: April 2022

AbstractDrought appears at flowering and boll formation for cotton frequently. However, reports on the impact of carbon dynamics in the subtending leaf on boll biomass under periodic droughts are limited. To investigate this, experiments were carried out with two cultivars (drought‐tolerant: Dexiamian 1; drought‐sensitive: Yuzaomian 9110), three water levels [soil relative water content (SRWC): control (75 ± 5)%, moderate drought (60 ± 5)%, severe drought (45 ± 5)%] and five drought durations (10, 17, 24, 31 and 38 days). A 38‐day drought declined the net photosynthetic rate of subtending leaf, which could be collectively attributed to the reduction in carboxylation with reduced ribulose‐1,5‐bisphosphate carboxylase activity, and stomal limitation with decreased stomatal conductance, along with the damage of photosynthetic apparatus with depressed maximum and actual photochemical quantum yield, leading to lower starch content. A 38‐day drought also increased the activities of sucrose phosphate synthase (SPS), sucrose synthase (Susy) and expressions of genes (GhSPS1, GhSPS2, GhSusA and GhSusB) associated with these enzymes, causing the accumulation of sucrose content, finally resulting in lower boll biomass. Some of the above parameters fully recovered under more than 17‐day moderate drought or over 10‐day severe drought, but boll biomass still decreased after re‐watering. Under 10‐day moderate drought, all aforementioned indices and boll biomass were completely recovered within 7 days of re‐watering, and the recovery capacity of Yuzaomian 9110 was lower than that of Dexiamian 1. Therefore, rapid recovery of photosynthesis and decline in the subtending leaf sucrose content to pre‐stress levels are important factors in lessening the impacts of drought on boll biomass and are indicative of cultivar tolerance to short‐term moderate water deficit.
A novel strategy for fabricating zirconia implants with a trabecular biomimetic porous surface
Authors: Seesala Venkata Sundeep , Dhara Santanu 
Published: April 2022

AbstractFor successful osseointegration of load‐bearing implants, an improved bone–implant contact area through a trabecular porous surface resulting in minimized stress shielding effect is highly desirable. We propose a novel strategy of green net shaping a ceramic dough, combined with a reticular foam replica method and gradient coating, to fabricate biomimetic porosity in a customizable ceramic dental implant for the first time. About 85 vol% porosity and 300–600‐μm pore size were evident in microCT and electron microscopy of the sintered samples, suitable for bone ingrowth. Excellent integrity at the interface along with homogeneous distribution of secondary alumina phase in zirconia matrix was achieved, despite the difference in the green state powder loading between the dough and the slurry.