bluuebunny/crossref_metadata_2025_split huggingface dataset:
Receipt of evidence-based care for children and adolescents with anxiety in Australia
Authors: Gandhi Esther , OGradey-Lee Maddison , Jones Alana , Hudson Jennifer L 
Published: January 2022

Objective: Cognitive-behavioural therapy is recommended as the first-line treatment for children and adolescents with anxiety. Despite its efficacy, a recent United Kingdom study indicated that few children with anxiety disorders receive cognitive-behavioural therapy. The primary aim of this study was to examine the receipt of cognitive-behavioural therapy for children and adolescents with elevated anxiety symptoms in Australia. Second, this study also examined whether there was a difference in the type of treatment received based on socioeconomic status and geographical location. Method: Using self-reported questionnaires, parents of children aged 4–18 years and children aged 12–18 years ( N = 784; elevated anxiety symptom sample n = 169) were recruited from four samples: community ( n = 164), school ( n = 177), clinic ( n = 16) and online panel provider ( n = 427). Participants reported on the child’s anxiety symptoms and the type of treatment (if any) the child received for their anxiety symptoms. Results: Results indicated that 19.5% of children and adolescents with elevated anxiety symptoms received evidence-based treatment (e.g. cognitive-behavioural therapy). Of those families who did seek help for anxiety in Australia, the majority (66.3%) did not receive cognitive-behavioural therapy. In addition, neither socioeconomic status (which was based on the Australian Index of Community Socio-Educational Advantage [ICSEA]) nor location (metropolitan vs regional/remote) affected whether individuals received evidence-based care or non-evidence-based care. Conclusion: Overall, children and adolescents in this study seeking support for their anxiety symptoms were not receiving adequate evidence-based care, regardless of socioeconomic status and location. These findings indicate there is a need to increase the receipt of cognitive-behavioural therapy for children and adolescents with anxiety symptoms. The findings should tentatively be interpreted, given data were collected during the COVID-19 pandemic.
High-Performance Fiber Reinforced Concretes in Virginia
Authors: Ozyildirim H. Celik , Sharifi Mary 
Published: January 2022

High-performance fiber reinforced concretes (HPFRCs) provide high workability, high compressive and tensile strengths, high ductility, and high durability. They exhibit strain and deflection hardening. The Virginia Department of Transportation (VDOT), U.S., has been experimenting with various types of HPFRC, including high early strength versions, to control cracking in transverse and longitudinal connections, shear keys, blockouts that connect adjacent members, overlays, and inverts of corrugated metal pipe culverts. This paper presents laboratory and field work using three classes of HPFRC for different VDOT applications. They have high ductility and very low permeability. In addition, Class I has normal compressive strength, Class II has high compressive strength, and Class III has high early compressive strength. Laboratory work consisted of preparing and testing of in-house or prepackaged HPFRC with varying ingredients and proportions using compression, indirect tension, flexure, and pull-out tests. Synthetic and steel fibers were added in different amounts. Mixtures were prepared in the mortar or pan mixers that produce good fiber dispersion. Laboratory and field testing indicated that all three classes of HPFRC had high ductility; strengths varied according to the class. Engineered cementitious composite in Class I had normal strength, ultra-high-performance concrete in Class II had the highest strength, and concretes in Class III had high early strength, enabling minimal traffic interruption. HPFRC selected from an appropriate class can be used successfully to enable early opening to traffic, provide a short splice length, achieve satisfactory adjacent member connections, and restrict crack width for a longer service life.
Poly(lactic acid-co-glycolic acid)-based celecoxib extended-release microspheres for the local treatment of traumatic heterotopic ossification
Authors: Lin Jialiang , Huang Junchao , Wu Jiang , Tang Bo , Li Congbin , Xiao Haijun 
Published: January 2022

Traumatic heterotopic ossification (THO) is a serious and common clinical post-traumatic complication for which there is no effective and safe drug treatment. Routine administration of nonsteroidal anti-inflammatory drugs (NSAIDs) after injury is extensively used approach for THO. However, serious adverse events can occur in the event of an overdose of NSAIDs. In our study, we have developed a poly(lactic acid-co-glycolic acid) (PLGA) microsphere by emulsifying solvent volatilization for the prolonged slow delivery of celecoxib (CLX). Three groups of celecoxib-poly(lactic acid-co-glycolic acid) microspheres (CLX–PLGA MPs) were prepared with particle sizes of 3.75±1.28 μm, 49.56±17.15 μm, and 94.98±42.53 μm. Meanwhile, related parameters of microspheres in each group were studied: drug loading (DL), encapsulation rate (EE), and slow-release behavior. The DL and EE of the 3 CLX–PLGA MPs did not vary significantly, and subsequently, we selected the second drug loading microspheres with a retardation period of about 70 days for subsequent experiments. Moreover, cellular and animal experiments suggest that the microspheres are biocompatible and can be safely applied to localized trauma tissue. Finally, it is demonstrated that CLX–PLGA MPs have an effect on inhibiting the osteogenic differentiation of bone marrow mesenchymal stem cells and have the potential to inhibit ectopic bone formation of the THO model in Sprague-Dawley rat. Therefore, this study suggests that CLX–PLGA MPs are expected to be applied topically in the early post-traumatic period to prevent the development of THO.
Does Diversity of Social Ties Really Matter More for Health and Leisure Activity than Number of Social Ties? Evidence from Later Adulthood
Authors: Brown Colette J. , Rook Karen S. 
Published: January 2022

Objectives Claims that the diversity of social ties matters more for health than the sheer number of ties have largely gone untested. This study accordingly compared the unique associations of number versus diversity of social ties with key health-related outcomes: functional limitations and leisure activities. Additionally, positive and ambivalent ties were distinguished. Methods Social networks, health, and leisure activities were assessed in a national sample of older adults ( N = 874; ages 65–91). Results Regression analyses revealed that number of ties related to each outcome at a magnitude comparable to, or exceeding, that of diversity in most models. For positive ties, number related more strongly than diversity to greater leisure activities. For ambivalent ties, number related more strongly than diversity to worse functional limitations. Discussion Contrary to prevailing views, diversity of ties is not necessarily more important than number of ties. Findings extend scientific understanding and approaches to interventions.
The precariat pandemic: Exploitation overshadowed by COVID-19 and workers’ strategies in Poland
Authors: Żuk Paweł , Żuk Piotr 
Published: January 2022

AbstractBased on the material obtained from focus group interviews conducted during the COVID-19 pandemic, the article analyses the mechanisms used by employers towards employees, as well as the adaptation strategies applied by those in precarious employment in Poland. The authors’ considerations refer to anti-worker changes introduced under the pretext of the pandemic in the capitalist labour market: layoffs and cuts in wages, manifestations of discrimination against precarious workers and the potential attitudes of employee self-defence. The authors conclude that it is almost certain that under the conditions of post-pandemic capitalism, the number of the precariat will grow and the neoliberal system will want to retain as many of the anti-worker solutions introduced in the shadow of the pandemic as possible.
Evaluation of a Prognostic Epigenetic Classification System in Chronic Lymphocytic Leukemia Patients
Authors: Grimm Christina , Herling Carmen Diana , Komnidi Anastasia , Hussong Michelle , Kreuzer Karl-Anton , Hallek Michael , Schweiger Michal R. 
Published: January 2022

Background: Methylation at 5 CpG sites was previously shown to classify chronic lymphocytic leukemia (CLL) into 3 prognostic subgroups. Here, we aimed to validate the marker set in an additional cohort and to evaluate its clinical utility for CLL patient stratification. Methods: We evaluated this epigenetic marker set in 79 German patients using bisulfite treatment followed by pyrosequencing and classification using a support vector machine-learning tool. Results: The n-CLL, i-CLL, and m-CLL classification was detected in 28 (35%), 10 (13%), and 41 (51%) patients, respectively. Epigenetic grouping was associated with IGHV mutational status ( P = 2 × 10−12), isolated del13q ( P = 9 × 10−6), del17p ( P = .015), complex karyotype ( P = .005), VH-usage, and clinical outcome as time to first treatment ( P = 1.4 × 10−12) and overall survival ( P = .003). Multivariate Cox regression analysis identified n-CLL as a factor for earlier treatment hazard ratio (HR), 6.3 (95% confidence interval [CI] 2.4-16.4; P = .0002) compared to IGHV mutational status (HR 4.6, 95% CI 1.9-11.3, P = .0008). In addition, when comparing the prognostic value of the epigenetic classification system with the IGHV classification, epigenetic grouping performed better compared to IGHV mutational status using Kaplan-Meier estimation and allowed the identification of a third, intermediate (i-CLL) group. Thus, our study confirmed the prognostic value of the epigenetic marker set for patient stratification in routine clinical diagnostics.
Hemispheric involvement in the comprehension of conventional metaphors in Arabic–Hebrew speakers
Authors: Ershaid Hadeel , Mashal Nira , Borodkin Katy 
Published: January 2022

Aims and objectives/purpose/research questions: Previous studies in pairs of typologically distant languages showed that hemispheric processing of metaphoric expressions differs in a native versus second language. The current research explored this finding in a pair of typologically close languages, Arabic and Hebrew. Design/methodology/approach: Forty-six Arabic native speakers who were proficient in Hebrew (second language; 30 women, aged 19–28) participated in a divided visual field (DVF) experiment. They were presented with conventional metaphors, literal expressions, and unrelated word pairs and asked to indicate whether the word pairs formed a meaningful expression. Participants were tested in spoken Arabic, literary Arabic, and Hebrew in separate blocks. Data and analysis: Mean reaction times and accuracy were analyzed using repeated-measures three-way analysis of variance, with language, visual field, and expression type as independent variables. Findings/conclusions: In contrast to previously reported findings, a left-hemisphere advantage or a bilateral pattern of processing was observed for conventional metaphors in both varieties of Arabic and in Hebrew, suggesting similar hemispheric processing in native and second language. Originality: Metaphor processing is examined in a pair of typologically close languages. Significance/implications: Our findings (in a pair of typologically close languages) differ from those previously reported in pairs of less similar languages, suggesting a modulatory role of language similarity in hemispheric processing of second-language metaphors.
Bilingual children acting as language brokers in Italy: Their affective and cognitive attitudes about the practice
Authors: Ceccoli Federica 
Published: January 2022

Aims and objectives: This paper sets out to examine Italian bilingual children’ attitudes about Child Language Brokering (CLB), with a focus on the perceived feelings (affective component of attitudes) and benefits (cognitive component of attitudes) related to CLB. The aim is to study the presence of any relationship between the affective and cognitive components of child language brokers’ attitudes, since they can affect the outcomes of CLB and their analysis can provide tools to reduce the stressors related to it. Methodology: A survey was carried out among 150 immigrant students attending vocational high schools in the Northern and Central regions of Italy. Demographic and linguistic data were processed by means of a descriptive analysis, while attitudinal scales were processed by means of both descriptive and inferential analysis. Findings: The results will show that the child language brokers who perceive stronger positive feelings about CLB also report stronger attitudes towards the benefits of the practice. Originality: Considering the lack of research examining child language brokers’ attitudes in Italy by means of attitude scales, and the lack of attention to the affective and cognitive dimensions of such attitudes, this study addresses this gap by investigating these two dimensions of CLB.
Comparison of Teriparatide and Combination of Cissus Quadrangularis and Dalbergia Sissoo on Bone Healing Against the Control Group in Maxillofacial Fractures: A Randomized Open-label Control Trial
Authors: PG Gigi , Chugh Ankita , Chaudhry Kirti , Kaur Amanjot , Kumar Pravin , Gaur Shubham , Kumar Shailendra , Singh Surjit 
Published: January 2022

Study Design Randomized Control Trial. Objective A randomized control trial was planned to aim to assess whether subcutaneous Injection of Teriparatide and Tablet Reunion (combination of Cissus Quadrangularis and Dalbergia sissoo) improves maxillofacial fracture healing as compared to the control group. Methods 24 patients of mandibular fracture with or without concomitant maxillofacial fractures were randomly divided into 3 equal groups (Group 1- Control, Group 2- Tablet Reunion, and Group 3- Injection Teriparatide) and the treatment duration was 4 weeks. Pain, fracture site mobility, bite force, serum markers, and radiographic healing were assessed preoperatively and postoperatively at regular intervals till 12 weeks. Results Group 2 showed early pain relief, although it was insignificant. Group 3 showed the highest anterior bite force at all the time points. Change in mean posterior bite force (PBF) showed a statistically significant increase at 8th week and 12th week in intergroup comparison; however, at 12th week, Group 3 was significantly better than Group 1 and reported the highest posterior bite force compared to other groups. Serum calcium and PTH level showed no significant difference, whereas Serum ALP showed a statistically significant increase in Group 3. The radiographic assessment showed no significant difference among the 3 groups. Conclusions Both the intervention group drugs showed a promising effect on accelerating the fracture healing and improving bite force restoration with the osteoanabolic action; however, early radiographic healing and increased serum osteogenic markers in Group 3 indicate its possible optimistic role in maxillofacial fracture healing.
Analysis of Neoclassical Canons in Adult Kenyans of Indian Descent
Authors: Sarna Krishan , Osundwa Tom Mulama , Kamau Martin , Sonigra Khushboo Jayant 
Published: January 2022

Study Design: Descriptive cross-sectional. Objective: To establish anthropometric norms and test the validity of four neoclassical canons among Kenyans of Indian descent. Methods: Using direct anthropometric landmarks, 3 vertical and 4 horizontal measurements were made on the faces of 130 adult Kenyans of Indian descent. The mean of each anthropometric measurement was calculated and a student t-test was used to identify significant gender differences. These results were compared to four neoclassical canons and the percentage of each canon and its variants were recorded. A chi-square test was then performed to assess any gender differences between these findings. Results: When comparing sexes, the anthropometric means of males were larger than those of females except for eye fissure length. In addition, only the upper third displayed sexual dimorphism. As for the neoclassical canons, the orbital canon was found to apply to 20.0% of males and 21.6% of females, followed by the naso-oral canon found in 16.4% of males and 17.6% of females, and the orbito-nasal canon present in 14.5% of males and 18.9% of females. The vertical canon was not found to be applicable to any participant. Conclusion: The facial morphometric measurements in this population differ from the described neoclassical canons since they do not apply to the majority of these individuals. Therefore surgeons should be guided by the observed population-specific differences during reconstructive and facial aesthetic surgery.
VIPCare: Understanding the support needed to create affective interactions between new caregivers and residents with dementia
Authors: Ghafurian Moojan , Francis Linda , Tao Zhuofu , Step Mary , Hoey Jesse 
Published: January 2022

Introduction In this paper, we study the support needed by professional caregivers of those with dementia, and present a first step toward development of VIPCare, a novel application with the goal of assisting new caregivers at care-centres in interacting with residents with dementia. Methods A mixed-methods study including two questionnaires, two focus groups, and seven co-design sessions with 17 professional caregivers was conducted to (a) understand caregivers’ challenges/approaches used to reduce negative interactions with persons with dementia, (b) identify the existing gaps in supporting information for improving such interactions, and (c) co-design the user interface of an application that aims to help improve interactions between a new professional caregiver and persons with dementia. A pre-questionnaire assessed knowledge of smartphones and attitude toward technology. A post-questionnaire provided an initial evaluation of the designed user interface. Results Focus groups emphasized the importance of role-playing learned through trial and error. The layout/content of the application was then designed in four iterative paper-prototyping sessions with professional caregivers. An iOS/Android-based application was developed accordingly and was modified/improved in three iterative sessions. The initial results supported efficiency of VIPCare and suggested a low task load index. Conclusions We presented a first step toward understanding caregiver needs and developing an application that can help reduce negative interactions between professional caregivers and those with dementia.
Diffusion of OXA-48 carbapenemase among urinary isolates of Klebsiella pneumoniae in non-hospitalized elderly patients
Authors: Šuto Sandra , Bedenić Branka , Likić Saša , Kibel Sara , Anušić Maja , Tičić Vladimira , Zarfel Gernot , Grisold Andrea , Barišić Ivan , Vraneš Jasmina 
Published: January 2022

Abstract
Background
Recently, a dramatic increase of Klebsiella pneumoniae positive for OXA-48 β-lactamases was observed first in the hospital setting and later in the long-term care facilities (LTCFs) and community in the Zagreb County, particularly, in urinary isolates. The aim of the study was to analyse the epidemiology and the mechanisms of antibiotic resistance of OXA-48 carbapenemase producing K. pneumoniae strains isolated from urine of non-hospitalized elderly patients.

Results
The isolates were classified into two groups: one originated from the LTCFs and the other from the community. Extended-spectrum β-lactamases (ESBLs) were detected by double disk-synergy (DDST) and combined disk tests in 55% of the isolates (51/92). The ESBL-positive isolates exhibited resistance to expanded-spectrum cephalosporins (ESC) and in majority of cases to gentamicin. LTCFs isolates showed a significantly lower rate of additional ESBLs and consequential resistance to ESC and a lower gentamicin resistance rate compared to the community isolates, similarly to hospital isolates in Zagreb, pointing out to the possible transmission from hospitals.ESBL production was associated with group 1 of CTX-M or SHV-12 β-lactamases. Ertapenem resistance was transferable from only 12 isolates. blaOXA-48 genes were carried by IncL plasmid in 42 isolates. In addition IncFII and IncFIB were identified in 18 and 2 isolates, respectively. Two new sequence types were reported: ST4870 and ST4781.

Conclusions
This study showed eruptive and extensive diffusion of OXA-48 carbapenemase to LTCFs and community population in Zagreb County, particularly affecting patients with UTIs and urinary catheters. On the basis of susceptibility testing, β-lactamase production, conjugation experiments, MLST and plasmid characterization it can be concluded that there was horizontal gene transfer between unrelated isolates, responsible for epidemic spread of OXA-48 carbapenemase in the LTCFs and the community The rapid spread of OXA-48 producing K. pneumoniae points out to the shortcomings in the infection control measures.
Effectiveness of clotting factor replacement therapy after antivenom treatment on coagulopathic envenomation following green pit viper bites: a retrospective observational study
Authors: Zeng Liangbo , Liang Qing , Liang Zijing , Han Jieyun , Wu Miaozhu , Liu Rong , Wang Xida 
Published: January 2022

Abstract
Background
Green pit vipers (GPVs), namely Trimeresurus albolabris and Trimeresurus stejnegeri accounts for most snakebites in Southern China. Green pit viper venom contains thrombin-like enzymes, resulting in defibrination syndrome. Using of clotting factor replacement after antivenom administration is controversial. The objective of this study was to investigate the effects of clotting factor replacement in coagulopathic patients with T. albolabris and T. stejnegeri bites after antivenom administration.

Methods
We retrospectively reviewed 123 patients who were bitten by T. albolabris and T. stejnegeri and were admitted to the Emergency Department of a hospital in Guangzhou, Southern China, from 2013 to 2019. Recovery of prothrombin time (PT) and fibrinogen level were compared among (1) fresh-frozen plasma (FFP) group; (2) cryoprecipitate (cryo) group; (3) FFP and cryo group; and (4) control group after antivenom administration.

Results
The incidence of coagulopathy was 31%. Persistent and late coagulopathy were the most common patterns among four groups. The median reduction in PT was 20.1 ± 31.2 s for FFP and cryo group. The median increase in fibrinogen level was very small: 0.05 ± 0.20 g/L for FFP group, 0.09 ± 0.37 g/L for cryo group and 0.07 ± 0.31 g/L for FFP and cryo group, respectively. The percentage of unimproved PT was markedly higher in the FFP and cryo group than the control group (P = 0.01 by log-rank test, P = 0.02 by Gehan-Breslow-Wilcoxon test). The percentage of unimproved fibrinogen level tended to be worse in the FFP and cryo group than the control group, but the different was marginal (P = 0.05 by Gehan-Breslow-Wilcoxon test, P = 0.07 by log-rank test). A total of 7.8% (7/90) of the patients in the clotting factor replacement groups developed anaphylaxis and heart failure.

Conclusion
There is no improvement in coagulopathy profile in patients with T. albolabris and T. stejnegeri bites who received clotting factor replacement after antivenom administration. But the results from GPVs may not be generalized to other species of venomous snakes.