bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aesthetic Removal of Foreign Body Granulomas of Forehead Via Pretrichial Approach
Authors: Kwon Hyeokjae , Ko Geonil , Choi Jaeik , Ha Yooseok , Kim Sunje , Kim Joo-Hak , Oh Sang-Ha , Song Seung Han 
Published: February 2022

Abstract:
In the field of plastic surgery, various filler types have been developed, which are widely used for cosmetic or reconstruction purposes. However, unregulated substances often injected by unlicensed practitioners may cause difficult-to-treat side effects, such as foreign body granulomas. Since the forehead is an exposed area and the lesions are likely extensive, complete surgical removal with inconspicuous scar can be difficult. In addition, pharmacological treatments, such as steroids, have only a temporary effect. The authors report successful cases of foreign body removal combined with subcutaneous forehead lift via a pretrichial approach for cosmetic satisfaction.
Ten patients who had received illegal filler injections that resulted in chronic granulomas on the forehead were studied. The granulomas were confirmed using sonography, and simultaneous foreign body removal and subcutaneous forehead lifts using pretrichial incisions were planned. For the surgical method, the forehead flap was carefully elevated to a uniform thickness in the subcutaneous plane via a pretrichial incision, and the foreign body was removed, paying attention to the forehead contour and nerve damage; excess skin was excised from the top of the flap to tighten the remaining skin on the forehead.
None of the patients developed complications, such as skin necrosis, infection, hematoma, or wound dehiscence, during the follow-up period. The functional and aesthetic outcomes were satisfactory in all the patients.
The subcutaneous forehead lift via a pretrichial incision seems to facilitate foreign body removal and improve the forehead deformity by tightening the remaining skin.
Implementation of 3D Printing and Computer-Aided Design and Manufacturing (CAD/CAM) in Craniofacial Reconstruction
Authors: Ahmed Kaleem S. , Ibad Hamza , Suchal Zafar A. , Gosain Arun K. 
Published: February 2022

Introduction:
The need for precision in craniomaxillofacial surgery has necessitated the evolution of new technology to improve patient outcomes and subsequently augment the road to recovery. Surgical planning has variables that may influence outcomes, including the image quality, image acquisition and image processing. Our review focuses on the advancement of three dimensional (3D) printing to create patient-specific constructs and therefore aims to study the current trends in the implementation of 3-D printing in craniofacial surgeries, including preferred 3-D printing techniques and materials, computer-aided design and manufacturing techniques, and outcomes as measured by recent studies.

Methods:
The authors conducted a systematic review following PRISMA guidelines to query PubMed, Embase, Cochrane library and ProQuest electronic databases. Mesh combinations and synonyms of “3Dprinting”, “3Dprinted”, “Craniofacial” were used. The authors included all original human studies that focused on the surgical implementation of 3D-printed implants for craniofacial defects.

Results:
After screening 1253 studies, the authors included 49 articles consisting of a total of 745 subjects for qualitative analysis. Titanium (n = 13) and polycaprolactone (n = 6) were the most common 3D printed materials studied while Color Jet Printing (n = 12) and Stereolithography (n = 11) were the most common techniques. All studies that compared implants acquired by 3D printing with those acquired by conventional approaches showed a significantly better prognosis, and reductions in operative time, length of stay, and immediate complications.

Conclusions:
The use of patient-specific alternative materials, planning software and 3-D printing techniques shows satisfactory results in craniofacial reconstruction. Future studies should include standard levels of objective measurements to make better comparisons.
Surveillance of Myopericarditis following COVID-19 Booster Dose Vaccination in a Large Integrated Health System
Authors: Sharff Katie A , Dancoes David M , Longueil Jodi L , Lewis Paul F , Johnson Eric S 
Published: February 2022

AbstractPurposeThe risk of myopericarditis following COVID-19 booster vaccination has not been extensively evaluated. We provide a timely case ascertainment of myocarditis following COVID-19 booster vaccine in individuals age 18-39 years from an integrated health system.MethodsWe studied a cohort of 65,785 Kaiser Permanente (KP) Northwest Health Plan members aged 18-39 years who received a COVID-19 vaccine booster at least 5 months following completion of the primary series. We identified cases of myopericarditis by searching the electronic health record for the National Center for Health Statistics (NCHS) text label for ‘myocarditis’ or ‘pericarditis’ diagnosis codes in all inpatient and outpatient encounters through January 18th 2022. The cohort was followed for 21 days after their booster. We excluded anyone with a documented diagnosis of myocarditis or pericarditis before their first COVID-19 vaccination. Two physicians independently reviewed the identified patient records and applied the CDC myocarditis and pericarditis surveillance case definition to classify records as confirmed, probable or excluded based on the prior published definition.ResultsOur method identified 6 patients who met the confirmed or probable CDC case definition for acute myocarditis or pericarditis within 21 days of COVID-19 booster dose among 65,785 eligible members. Four cases occurred in 27,253 men. Overall, we estimated 9.1 cases (exact 95% CI 3.4 to 19.9) of post-booster myopericarditis per 100,000 booster doses given. In men, we estimated 14.7 cases (exact 95% CI 4.0 to 37.6) per 100,000 booster doses given.ConclusionWe identified a rate of 9.1 cases of myopericarditis per 100,000 COVID-19 booster doses which is higher than prior estimates reported by the Vaccine Adverse Event Reporting System (VAERS). Myopericarditis occurs following COVID-19 booster vaccine and may be underreported by current surveillance methods. High sensitivity of these case estimates is essential when modeling risk and benefit for sequential COVID-19 vaccinations for the general population.
Differential durability of humoral and T cell immunity after two and three BNT162b2 vaccinations in adults aged >80 years
Authors: Romero-Olmedo Addi J. , Schulz Axel Ronald , Hochstätter Svenja , Gupta Dennis Das , Hirseland Heike , Staudenraus Daniel , Camara Bärbel , Volland Kirsten , Hefter Véronique , Sapre Siddhesh , Krähling Verena , Müller-Kräuter Helena , Mei Henrik E. , Keller Christian , Lohoff Michael 
Published: February 2022

AbstractA third mRNA-based “booster” vaccination is the favored strategy to maintain protection against SARS-CoV-2 infection. Yet, significant waning of specific immunity within six months after 2nd vaccination, along with higher incidence of breakthrough infections associated with the time elapsed since 2nd vaccination raises concerns regarding the durability of immunity also after 3rd vaccination. We assessed virus-specific serum antibody and T cell response in the blood after vaccination with the mRNA vaccine BNT162b2 in more than 50 individuals older than 80 years. All old adults demonstrated a strong humoral response to 3rd vaccination which was at average higher and waned slower than the response to 2nd vaccination, indicative of enhanced humoral immunity. In contrast, their respective T cell response quantitatively limited to the level obtained after 2nd vaccination, with similar waning over time and no evidence for enhanced IFNg production. Because BNT162b2-mediated protection from the Omicron variant relies more on T cells than antibodies, our findings raise concern on the durability of protection from the Omicron variant by BNT162b2 in the senior population.
SARS-CoV-2 seroprevalence in a rural and urban community household cohort in South Africa, after the third wave, April-November 2021
Authors: Kleynhans Jackie , Tempia Stefano , Wolter Nicole , Gottberg Anne von , Bhiman Jinal N. , Buys Amelia , Moyes Jocelyn , McMorrow Meredith L. , Kahn Kathleen , Gómez-Olivé F. Xavier , Tollman Stephen , Martinson Neil A. , Wafawanaka Floidy , Lebina Limakatso , Toit Jacques du , Jassat Waasila , Neti Mzimasi , Brauer Marieke , Cohen Cheryl ,   the PHIRST-C Group
Published: February 2022

AbstractBy November 2021, after the third SARS-CoV-2 wave in South Africa, seroprevalence was 60% (95%CrI 56%-64%) in a rural and 70% (95%CrI 56%-64%) in an urban community; highest in individuals aged 13-18 years. High seroprevalence prior to Omicron emergence may have contributed to reduced severity observed in the 4th wave.Article Summary LineIn South Africa, after a third wave of SARS-CoV-2 infections, seroprevalence was 60% in a rural and 70% in an urban community, with case-to-infection, - hospitalization and -fatality ratios similar to the second wave.
Integrated metagenomic and bile acid metabolomic analysis of human fecal microbiota transplantation for recurrent Clostridioides difficile and/or inflammatory bowel diseases
Authors: Ramos Ruben Jesus Faustino , Zhu Chencan , Joseph Dimitri F , Thaker Shubh D , LaComb Joseph F , Markarian Katherine , Littmann Eric R. , Lee Hannah J , Petrov Jessica C , Monzur Farah , Morganstern Bradley M , Bucobo Juan Carlos , Buscaglia Jonathan M , Chawla Anupama , Small-Harary Lesley , Gathungu Grace , Morganstern Jeffrey A , Yang Jie , Li Jinyu , Robertson Charles E , Pamer Eric G. , Frank Daniel N , Cross Justin R , Li Ellen 
Published: February 2022

AbstractBackgroundFecal microbiota transplantation (FMT) is an effective treatment of recurrent Clostridioides difficile infections (rCDI). In comparison, FMT has more limited efficacy in treating either ulcerative colitis (UC) or Crohn’s disease (CD), two major forms of inflammatory bowel diseases (IBD). We hypothesize that FMT recipients with rCDI and/or IBD have baseline fecal bile acid (BA) compositions that differ significantly from that of their healthy donors and may be normalized by FMT.AimTo study the effect of single colonoscopic FMT on the microbial composition and function of recipients with rCDI and/or IBD.MethodsMulti-omic analysis was performed on stools from 55 pairs of subjects and donors enrolled in two prospective single arm FMT clinical trials [ClinicalTrials.gov ID:NCT03268213, 479696, (IND) 15642, ClinicalTrials.gov ID: NCT03267238, IND 16795]. Fitted linear mixed models were used to examine the effects of four recipient groups (rCDI - IBD, rCDI + IBD, UC - rCDI, CD - rCDI), FMT status (Donor, pre-FMT, 1-week post-FMT, 3-months post-FMT) and first order Group*FMT interactions.ResultsFMT was effective in preventing rCDI for up to one year in 92% of the rCDI - IBD group and 75% of the rCDI + IBD recipients. The donor-recipient Sørensen similarity index was < 0.6 in all donor-CDI recipient pairs but > 0.6 in some donor-IBD only recipient pairs at baseline. Increasing post-FMT similarity indices > 0.6 in IBD recipients, was not clearly associated with reduced fecal calprotectin levels. Fecal secondary BA levels were lower in rCDI ± IBD and CD – rCDI recipients compared to donors. FMT restored secondary BA levels in these recipients. Metagenomic baiE gene and some of the 8 bile salt hydrolase (BSH) phylotype abundances were significantly correlated with fecal BA levels.ConclusionRestoration of multiple secondary BA levels, including those recently implicated in immunomodulation, are associated with restoration of fecal baiE gene counts, suggesting that the 7-α-dehydroxylation step is rate-limiting.
Impact of low-dose intrathecal morphine on orthopedic surgery: a protocol of a systematic review and meta-analysis of randomized controlled trials
Authors: Lei Yue , Guanzhang Mu , Zengmao Lin , Haolin Sun 
Published: February 2022

ABSTRACTIntroductionPatients undergoing orthopedic surgery usually suffer considerably from peri-operative pain and intrathecal morphine (ITM) has recently been used as an effective analgesic method. The intrathecal morphine dose achieving optimal analgesia for orthopedic surgery while minimizing side effects has not yet been determined. There is currently a lack of literature synthesis on the safety and effects of low-dose ITM on orthopedic surgery.Methods and analysisA thorough literature search will be performed on multiple electronic databases and trial registries until January 11th 2022, and reference lists will be examined. Two independent reviewers will select studies, extract data and assess the risk of bias and quality of the included studies. We will select randomized controlled trials comparing low-dose ITM (<100μg) with high-dose ITM (<200μg) or placebo treatment or other comparatives. We will assess the risk of bias using the Cochrane risk of bias tool and Jadad score will be applied to assess the quality of each included trial. We will also use Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) to determine the confidence in effect estimates. Publication bias will be evaluated by visually inspecting funnel plots and Egger regression asymmetry test in estimations of more than 10 trials. Standard meta-analysis will be performed using R package meta.Ethics and disseminationThe results of this systematic review and meta-analysis will be disseminated through peer-reviewed journal and related conferences. The data used in this meta-analysis will not contain individual patient data and ethical approval is therefore not required.
Microbial dysbiosis and metabolic disorders promote rheumatoid arthritis across successive stages: a multi-omics cohort study
Authors: Cheng Mingyue , Zhao Yan , Cui Yazhou , Zhong Chaofang , Zha Yuguo , Li Shufeng , Cao Guangxiang , Li Mian , Zhang Lei , Ning Kang , Han Jinxiang 
Published: February 2022

SummaryBackgroundRheumatoid arthritis (RA) is a chronic inflammatory disease that typically progresses through four stages, from mild stiffness to severe disability. The critical involvement of gut microbial dysbiosis in promoting RA has been intriguing. The aim of this study was to investigate stage-specific roles of microbial dysbiosis and metabolic disorders in pathogenesis across successive stages of RA.MethodsIn this multi-omics cohort study, fecal metagenomic, plasma metabolomic data were collected from 76 patients grouped into four RA stages, 19 patients with osteoarthritis, and 27 healthy individuals in China. A non-redundant gene catalogue was constructed, functionally annotated, and clustered into metagenomic species (MGS). Leave-one-out analysis was performed to determine the MGS that most drove the microbial dysfunctions with RA across stages. Random forest algorithm was performed to investigate diagnostic potential of microbial or metabolic features for each stage. Additionally, to verify the bacterial invasion of the joint synovial fluid, we conducted 16S rRNA gene sequencing, bacterial isolation, and scanning electron microscopy on joint synovial fluid from another cohort of 271 RA patients grouped into four RA stages.FindingsWe found that microbial dysbiosis and metabolic disorders had stage-specific effects on RA progression. For instance, arginine succinyltransferase pathway was elevated mainly in the second and third stages of RA (p=1·4×10−3), which was driven byEscherichia coli, and it was correlated with the increase of the rheumatoid factor (p=1·35×10−3). Considerable elevation of methoxyacetic acid (p=1·28×10−8) and cysteine-S-sulfate (p=4·66×10−12) might inhibit osteoblasts in the second stage and enhance osteoclasts in the third stage, respectively. Moreover, fecal microbesEggerthella lentaandBifidobacterium longumthat were exclusively elevated in the fourth stage, were also detected in the joint synovial fluid.InterpretationOur findings elucidate for the first time the stage-specific roles of microbial dysbiosis and metabolic disorders across successive stages of RA, which open up new avenues for RA prognosis and therapy. We demonstrate the buildup of these effects might induce microbial invasion of the joint synovial fluid in the fourth stage of RA.
Epilepsy-associated increase in gonadotropin-releasing hormone neuron firing in diestrous female mice is independent of chronic seizure burden severity
Authors: Li Jiang , Christian-Hinman Catherine A. 
Published: February 2022

AbstractReproductive endocrine disorders are common comorbidities of temporal lobe epilepsy (TLE). Our previous studies using the intrahippocampal kainic acid (IHKA) mouse model of TLE demonstrated that many females show prolonged estrous cycles and hypothalamic gonadotropin-releasing hormone (GnRH) neurons exhibit elevated firing during diestrus. However, it is unknown whether the degree of change in GnRH neuron activity is dependent on epilepsy severity. Here, we used 24/7 in vivo EEG and in vitro electrophysiological recordings in acute brain slices to assess GnRH neuron firing in relation to chronic seizure burden in diestrous female mice at two months after IHKA injection. We found that percentage of time in seizure activity in the 24 hours prior to slice preparation is an accurate proxy of overall seizure burden. Firing rates of GnRH neurons from EEG-recorded IHKA mice were increased in comparison to controls, but no relationships were found between GnRH neuron firing and seizure burden measured in vivo. The independence of GnRH neuron firing rate in relation to seizure burden was unaffected by GnRH neuron soma location or estrous cycle length. Furthermore, GnRH neuron firing rates were not yet different from control values when measured 1 month after injection when epileptogenesis is already complete in IHKA mice. This result suggests a potential window for intervention to prevent epilepsy-associated GnRH neuron dysfunction. These findings indicate that the severity of epilepsy and the degree of downstream disruption to GnRH neuron activity are independent, suggesting that susceptibility to reproductive endocrine comorbidities is driven by other risk factors.
The chemokine receptor CXCR3 promotes CD8+T cell-dependent lung pathology during influenza pathogenesis
Authors: Guo Kai , Yombo Dan J.K , Xu Jintao , Wang Zhihan , Schmit Taylor , Tripathi Jitendra , Hur Junguk , Sun Jie , Olszewski Michal A. , Khan Nadeem 
Published: February 2022

ABSTRACTWhile the role of CD8+T cells in influenza clearance is established, their contribution to pathological lung injury is increasingly appreciated. To explore if protective versus pathological functions can be linked to CD8+T cell subpopulations, we dissected their responses in influenza-infected murine lungs. Our single-cell RNASeq (scRNAseq) analysis revealed significant diversity in CD8+T cell subpopulations during peak viral load vs. infection-resolved state. While enrichment of Cxcr3hiCD8+T effector (Teff) subset was associated with a more robust cytotoxic response, both CD8+Teffand CD8+T central memory (TCM) exhibited equally potent effector potential. The scRNAseq analysis identified unique regulons regulating the cytotoxic response in CD8+T cells. The neutralization of CXCR3 mitigated lung injury without affecting viral clearance. IFN-γ was dispensable to regulate the cytotoxic response of Cxcr3hiCD8+T cells. Collectively, our data imply that CXCR3 interception could have a therapeutic effect in preventing influenza-linked lung injury.TEASERThe CXCR3 expressing CD8+ T cell subset causes severe lung pathology and exacerbates disease severity without affecting viral clearance during influenza infection
A model of online food delivery service quality, customer satisfaction and customer loyalty: a combination of PLS-SEM and NCA approaches
Authors: Koay Kian Yeik , Cheah Chee Wei , Chang Yi Xuan 
Published: February 2022

PurposeThe main purpose of this study is to explore how online food delivery (OFD) service quality influences customer satisfaction and customer loyalty.Design/methodology/approachA total of 307 useable data collected from existing users of OFD services in Malaysia are used to verify the proposed hypotheses through partial least squares structural equation modelling (PLS-SEM). Necessary condition analysis (NCA) is also conducted to identify the necessary conditions for customer satisfaction and customer loyalty.FindingsThe PLS results show that five dimensions of OFD service quality, including assurance, maintenance of meal quality and hygiene, reliability, security and system operation, are significant to customer satisfaction. Traceability is found to have no significant influence on customer satisfaction. Furthermore, customer satisfaction is a significant predictor of customer loyalty. The NCA results show that all dimensions of OFD service quality are necessary conditions for customer satisfaction and customer satisfaction is a necessary condition for customer loyalty.Originality/valuePast studies have mainly utilised the sufficiency logic to understand customer satisfaction and customer loyalty in the context of the OFD. This study is the first to perform NCA that relies on necessity logic to identify necessary conditions for customer satisfaction and customer loyalty.
Off-farm employment experience triggers heterogeneity of exiting part-time farming in rural China
Authors: Bai Yunli , Wang Weidong , Zhang Linxiu 
Published: February 2022

PurposeThe purpose of this paper is to examine the occupational specialization in rural labor market by analyzing the nature of part-time farming in rural China and estimating the impact of off-farm experience on the individual’s persistence and exit of part-time farming as well as its heterogeneity.Design/methodology/approachUsing the panel data collected in 100 villages and 2,000 households across five provinces in 2008, 2012 and 2016, this study provides insights on the nature of part-time farming in rural labor market and find the impact and mechanism of off-farm employment experience on exiting part-time farming by adopting event history analysis.FindingsPart-time farming is a stable long-run occupation in rural labor market of China from 2008 to 2015. Off-farm employment experience generally has positive effects on long-term part-time farming and the probability of exiting part-time farming. It significantly promotes female to exit part-time farming.Originality/valueBased on the two-sector model, this study builds a conceptual framework of off-farm experience and occupational specialization and sets a theoretical basis of hazard model when using event history analysis. This study contributes to identify the impact of off-farm experience on persistence and exiting part-time farming in recent years. The empirical findings support the policy of promoting off-farm employment to improve occupational specialization.