bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL-23 Promotes Neutrophil Extracellular Trap Formation and Bacterial Clearance in a Mouse Model of Alcohol and Burn Injury
Authors: Li Xiaoling , Luck Marisa E , Herrnreiter Caroline J , Cannon Abigail R , Choudhry Mashkoor A 
Published: January 2022

Abstract
Our previous studies have shown that ethanol intoxication combined with burn injury increases intestinal bacterial growth, disrupts the intestinal barrier, and enhances bacterial translocation. Additionally, studies show that Th17 effector cytokines IL-17 and IL-22, which are dependent on IL-23, play important roles in maintaining intestine mucosal barrier integrity. Recent findings suggest neutrophils are a significant source of IL-17 and IL-22. We determined the effect of ethanol and burn injury on neutrophil IL-17 and IL-22 production, as well as their ability to phagocytose and in bacterial clearance, and whether these effects are modulated by IL-23. Mice were given ethanol 4 h prior to receiving ∼12.5% total body surface area burn and were euthanized day 1 after injury. We observed that intoxication combined with burn injury significantly decreases blood neutrophil phagocytosis and bacteria killing, as well as their ability to produce IL-17 and IL-22, compared with sham vehicle mice. The treatment of neutrophils with rIL-23 significantly increases IL-22 and IL-17 release and promotes expression of IL-23R, retinoic acid–related orphan receptor γt, Lipocalin2, and Nod-like receptor 2 following ethanol and burn injury. Furthermore, IL-22– and IL-17–producing neutrophils have enhanced neutrophil extracellular trap formation and bacterial killing ability, which are dependent on IL-23. Finally, although we observed that peritoneal neutrophils harvested after casein treatment are functionally different from blood neutrophils, both blood and peritoneal neutrophils exhibited the same response to rIL-23 treatment. Together these findings suggest that IL-23 promotes neutrophil IL-22 and IL-17 production and their ability to kill bacteria following ethanol and burn injury.
One-year mortality rates and factors affecting mortality after surgery for fracture neck of femur in the elderly
Authors: Dhingra Mohit , Goyal Tarun , Yadav Arvind , Choudhury Arghya Kundu 
Published: January 2022

Context:
Fractures around hip in elderly are associated with significant morbidity and mortality.

Aim:
This sudy aims to investigate 1-year mortality rates and risk factors associated with this mortality. Effect of delay in surgery on mortality rates will also be studied. Our null-hypothesis was that there is no association between common comorbid conditions or delay in surgery on 1-year mortality rates.

Study Settings and Design:
Patients 60-years and above who underwent operative treatment for fracture of neck of femur between January 2018 and February 2019 were included in this retrospective study.

Materials and Methods:
Demographic and clinical data were collected from hospital information system and inpatient case records. Patients were followed up with quality of life (QoL) assessment with short form-12 (SF-12) at 1 year. Mortality during this period was also evaluated.

Statistical Analysis:
Continuous factors were expressed as means, standard deviations. Different risk factors between the patients alive and dead were studied using Fisher's exact test.

Results:
Nineteen out of 95 patients died at the end of 1 year. Smoking, hypertension, diabetes, low hemoglobin, raised total leukocyte count, low serum albumin, delay in surgery (>1 week), higher American Society of Anesthesiologist grade, and postoperative blood transfusion were significantly associated with higher mortality rates. Mean SF-12 QoL scores at 1 year was 35.6 ± 6.3.

Conclusion:
Hip fractures in elderly are associated with higher mortality rates. Results of this study indicate that patients at a higher risk of mortality may be identified and help in preoperative optimization with the aim to reduce mortality. However, these findings need to be verified by further studies with a relatively larger sample size and longer follow-up period.
Bone Alkaline Phosphatase and Urine Hydroxyproline Assay in Pre and Postmenopausal Women in the State of Sikkim and its Correlation with Bone Mineral Density
Authors: Rai Anne Deborah , Sherpa Mingma L. , Singh Amumacha , Thejaswi S. G. , Bhutia Rinchen D. 
Published: January 2022

Introduction:
Osteoporosis could be viewed as a metabolic disease. The WHO guidelines for diagnosing osteoporosis reflect structural damage only and not the metabolic imbalance that leads to it. Biochemical markers of bone turnover have been shown to provide valuable information for diagnosing and monitoring metabolic bone disease. The present study analyzed bone-specific alkaline phosphatase (BALP) and urinary hydroxyproline in pre- and postmenopausal women and correlated them with changes in bone mineral density (BMD) in the state of Sikkim. The study also intended to know the ethnicity-based disease burden in Sikkim.

Materials and Methods:
A hospital-based cross-sectional study was done at a tertiary hospital in Sikkim. Blood and 24-h urine samples from 50 premenopausal and 50 postmenopausal women were analyzed for total alkaline phosphatase (ALP), BALP, and Urine Hydroxyproline. BMD was measured using the quantitative ultrasound technique by Achilles densitometer.

Results:
There was a statistically significant increase in serum calcium (P = 0.01), ALP (P = 0.01), and urine hydroxyproline (P = 0.03) levels in postmenopausal women as compared to premenopausal women. Although ALP was higher in postmenopausal women, BALP isoform was more elevated in premenopausal women (P = 0.001). BMD was significantly lower in postmenopausal women (P < 0.001). It was also noted that there was a significant difference in BMD between tribal and nontribal populations (P = 0.003). Total ALP and BALP as the bone formation marker and urine hydroxyproline as a bone resorption marker added statistically significant r to BMD prediction (P < 0.05).

Conclusion:
In this study, BALP combined with Urine Hydroxyproline was helpful as a screening biomarker to predict osteoporosis in postmenopausal women.
Conversión de prueba cutánea de derivado proteico purificado durante el tratamiento con anti-TNF-α
Authors: Abdala Brian Marcelo , Ringer Ariana , Ruffino Juan Pablo , Martínez María Florencia , Argento María Cecilia , Chulibert Serenela , Carbone Daniela , Lucci Franco , Gatica Agostina , Rombo Graciela , Palatnik Mariano , Cortese María Noel , Lagrutta Mariana , Finucci Curi Baltasar , Co Adriana , Abdala Marcelo Alberto 
Published: January 2022

Introducción: los anti-TNF-α se asocian con mayor riesgo de desarrollar tuberculosis (TB). La prueba del derivado proteico purificado (purified protein derivative, PPD) se emplea para diagnosticar infección de tuberculosis latente (ITL). Se recomienda el cribado para TB previo al inicio de terapia anti-TNF-α y el seguimiento para evaluar la posible conversión de la PPD durante el tratamiento. El tratamiento de la ITL puede reducir el riesgo de desarrollar enfermedad activa en un 90%.
Objetivos: actualmente los resultados de conversión de la PPD y su interpretación durante el tratamiento anti-TNF-α son variables, por tal motivo nos propusimos conocer la frecuencia de conversión de la PPD en este grupo de pacientes de nuestro medio.
Pengaruh Pendistribusian Dana Zakat Produktif terhadap Tingkat Pendapatan Mustahik di DPU Daarut Tauhid Bogor
Authors: Safitri Anggia , Riyanto Riyanto , Damayanthy Dessy 
Published: January 2022

ABSTRACT
Lembaga Amil Zakat Dompet Peduli Ummat Daarut Tauhiid (DPU DT to contribute to community empowerment in the economic field, Education, preaching, humanity and social. This research is motivated by the problem of how to distribute or distribution of productive zakat funds to the level of economic income mustahik. Seeing the problems experienced by mustahik better than before and after becoming a mustahik, with the empowerment of this productive zakat mustahik is expected to be able to run his business continuously so that increase economic income. This research is a descriptive-quantitative research using the Simple Linear Regression method. Sample in research this amounted to 20 respondents. Data collection using a questionnaire and Data processing using analysis tools SPSS Version 26.0, research result shows that the distribution of productive zakat funds has an effect on Mustahik's income level is 61.1%, while the rest are influenced by another factor of 38.9%. Therefore, Productive zakat distribution in Business capital by DPU DT Bogor Branch can be increased.
Sindrom Komisura Wernekink; Patofisiologi dan Diagnosa: Sebuah Tinjauan Literatur
Authors: Putri Novi Jayanti Sukarno 
Published: January 2022

Sindroma commissure Wernekink adalah sindrom midbrain yang langka yang secara selektif mempengaruhi komisura Wernekink, ditandai dengan ataksia serebelar bilateral dan gangguan pergerakan mata, terutama oftalmoplegia internuklear. Defisit neurologis yang terlihat pada WCS diyakini disebabkan oleh gangguan pada tangkai serebelar superior, fasciculi longitudinal medial, dan traktus tegmental sentral. Pemeriksaan radiologis yang berguna yaitu pada magnetic resonance imaging (MRI) dimana didapatkan gambaran "Lesi berbentuk hati" yang dianggap sebagai gambaran khas dari infark medular medial bilateral.

Wernekink commissure syndrome is a rare midbrain syndrome selectively affecting the Wernekink commissure, characterized by bilateral cerebellar ataxia and eye movement disorders, especially internuclear ophthalmoplegia. Neurologic deficits seen in WCS are believed to be caused by disruptions of the superior cerebellar peduncles, medial longitudinal fasciculi, and the central tegmental tract. Initially, a “heart-shaped lesion” on magnetic resonance imaging (MRI) was thought to be a distinctive presentation of bilateral medial medullary infarction.
The First Reconstruction
Authors: Gosse Van 
Published: January 2022

It may be difficult to imagine that a consequential black electoral politics evolved in the United States before the Civil War, for as of 1860, the overwhelming majority of African Americans remained in bondage. Yet free black men, many of them escaped slaves, steadily increased their influence in electoral politics over the course of the early American republic. Despite efforts to disfranchise them, black men voted across much of the North, sometimes in numbers sufficient to swing elections. In this meticulously-researched book, Van Gosse offers a sweeping reappraisal of the formative era of American democracy from the Constitution's ratification through Abraham Lincoln’s election, chronicling the rise of an organized, visible black politics focused on the quest for citizenship, the vote, and power within the free states. Full of untold stories and thorough examinations of political battles, this book traces a First Reconstruction of black political activism following emancipation in the North. From Portland, Maine and New Bedford, Massachusetts to Brooklyn and Cleveland, black men operated as voting blocs, denouncing the notion that skin color could define citizenship.
PRACTICE OF BUSINESS INTELLIGENCE BY SMEs IN BURKINA FASO
Authors: Ouedraogo Dr. Honore , Compaoré Dr Issa , Nassè Dr. Théophile Bindeouè 
Published: January 2022

The integration of information technologies in business management is essential in the context of the globalization of trade and competition. Small and medium-sized enterprises (SMEs) in Burkina Faso do not escape this constraint with a view to improving productivity. Through an exploratory approach, the objective is to provide a better understanding of the appropriation of Business Intelligence by SMEs in Burkina Faso. Thanks to a mixed, quantitative and qualitative method, sixty SMEs were surveyed and three resource people were interviewed from February to April 2021. The descriptive statistics and the analysis grid led to the results according to which the practice of BI by SMEs in Burkina Faso is at an elementary level, despite its relevance for the organizational performance of SMEs. It should be noted that several myths are to be defied and to be able to adapt BI to the needs and realities of SMEs in Burkina Faso for its popularization.
Keywords: Information System, Business Intelligence, Small and Medium Enterprises.
Local antibiotic treatment with calcium sulfate as carrier material improves the outcome of debridement, antibiotics, and implant retention procedures for periprosthetic joint infections after hip arthroplasty – a retrospective study
Authors: Reinisch Katharina , Schläppi Michel , Meier Christoph , Wahl Peter 
Published: January 2022

Abstract. Purpose: Debridement, antibiotics, and implant retention (DAIR) is an established treatment modality in periprosthetic joint infections (PJIs), but success rates vary. This study compared the success of DAIR for PJIs after a total hip arthroplasty (THA), with or without local antibiotic delivery with CaSO4 as the carrier material.
Methods: A retrospective review of DAIR for PJIs after THA performed between 2010 and 2018, including 41 patients is conducted. A total of 27 patients were treated by DAIR with local antibiotics with CaSO4 as the carrier material, and 14 patients were treated by a standard DAIR. The endpoints were treatment failure, defined as the need for a reoperation, either a second DAIR or a prosthesis removal or exchange due to persistent or recurrent infection, the initiation of a long-term suppressive antibiotic treatment, or death related to infection.
Results: Considering any reoperation as an outcome, 11 of 14 cases treated without AB-CaSO4 (79 %) and 4 of the 27 cases treated with
AB-CaSO4 failed (15 %). Considering revision as an outcome, 9 out of 14 cases treated without AB-CaSO4 (64 %) and 4 of the 27 cases treated with AB-CaSO4 (15 %) failed. A Kaplan–Meier survival analysis showed that local antibiotic delivery with CaSO4 as the carrier material led to a significantly longer infection-free survival, considering any surgical revision (p<0.0001; hazard ratio 8.9 (95 % CI 2.8–28.2)) or revision with component exchange (p=0.0015; hazard ratio 5.6 (95 % CI 1.7–18.2)) as the endpoint.
Conclusion: The addition of local antibiotics with CaSO4 as the carrier material to DAIR for PJIs after THA significantly increases success rates, such as infection-free survival, any reoperation, and revision with component exchange in particular.
Meningkatkan Kesadaran Kaum Muda dengan Memahami Penghasilan Tidak Kena Pajak bagi Siswa SMA Swasta Indonesia Membangun Medan
Authors: Hutabarat Metyria Imelda , Firmansyah Edy , Sitompul Saleh , Loo Petrus , Harahap Nirwana Dewi , Zai Febri Yanto 
Published: January 2022

Kaum muda merupakan generasi bangsa yang memerlukan wawasan pajak. Kegiatan pengabdian masyarakat berupa workshop mengenai penghasilan tidak kena pajak. Banyaknya masyarakat di berbagai bidang yang belum mengetahui akan pemahaman penghasilan tidak kena pajak disebabkan belum disosialisasikan dengan masif kepada masyarakat, sehingga masih ada yang belum memahaminya. Sosialisasi yang dilakukan hanya berkisar kepada lembaga usaha dan orang pribadi yang bisa dijadikan objek pajak menurut Undang-Undang. Sosialisasi belum menyebar bagi kaum muda pada lembaga pendidikan seperti SMA, SMK maupun ke pihak Universitas agar mereka paham dan mengerti mengenai penghasilan tidak kena pajak dan perhitungannya. Pemahaman ini akan tertanam di benak siswa atau mahasiswa ketika mereka kelak sudah menjadi wajib pajak. Kegiatan workshop penghasilan tidak kena pajak telah dilaksanakan dengan baik, para peserta workshop yakni para siswa SMA Swasta Indonesia Membangun Medan antusias untuk mengikuti kegiatan ini. Dengan adanya kegiatan workshop para peserta memiliki pengetahuan, pemahaman dan mampu membuat tingkatan penghasilan tidak kena pajak, serta penghitungan tentang kasus penghasilan tidak kena pajak, sehingga dapat dipraktekkan dan diaplikasikan di lingkungan sekitar.
INFLUENCE OF PRODUCT QUALITY AND BRAND TRUST ON CONSUMER SATISFACTION OF EMINA COSMETIC PRODUCTS
Authors: Jamilah Ratih Siti 
Published: January 2022

The objective of this research was to determine the effect of product quality and brand trust on consumer satisfaction of Emina's cosmetic products on Emina consumers in Tanjung Morawa Village A Dusun II Deli Serdang Regency. This research used a quantitative descriptive approach. The population were 80 respondents in which the entire population was sampled with a sampling technique by using a saturated sampling technique. Based on the results of the research that has been done, get the simultaneous test (f test) of the two independent variables on the dependent variable. The results showed that the variables of product quality and brand trust had a significant effect on consumer satisfaction, it was seen from the value of fobserved (204.580) > ftable (3.12) with a significant value of 0.000 <0.05. With an R square value of 0.842. This means that the effect of variable X1 and variable X2 on variable Y is 84.2%, while the remaining 15.8% is affected by other variables.
Mesoscale features of monsoon precipitation system as revealed by the objective analysis of rainfall from the use of high dense land rainfall observations
Authors: ROY BHOWMIK S. K. , JOARDAR D. , ROY SOMA SEN , HATWAR H. R. 
Published: January 2022

A simple method for daily rainfall analysis at the resolution of 1° × 1° Lat./Long. over Indian monsoon region is applied from the use of dense land observations and satellite rainfall estimates for the month of June 2001. The results obtained show that the analysis is able to capture large scale as well as mesoscale features of monsoon precipitation system. The availability of this data is expected to be very useful for the synoptic meteorologists and numerical weather prediction modelling community.
Statistical modelling of rainfall data using modified Weibull distribution
Authors: MURALIDHARAN K. , LATHIKA P. 
Published: January 2022

This article presents the aspects of modeling rainfall data using a modified version of weibull distribution. This model takes care of those days reported with zero rainfall corresponding to the dry days (i.e., no rain day) during a season (in life testing context this situation is called instantaneous failures). We propose a modified weibull distribution as a suitable model to represent such situations by mixture of a singular distribution at zero and a two parameter weibull distribution. We derive Maximum Likelihood Estimates (MLE) of the parameters and their joint asymptotic distributions as well as that of the mean rainfall. Based on the above results a 95% confidence interval for the mean of the mixture distribution is obtained. The method is illustrated with actual measured data on rainfall from two stations namely, Jalgaon and Coimbatore divisions in India during a 10 year period from 1961 to 1970. Correspond to each year, the estimates of the parameters, average rainfall and confidence intervals are provided.
Inter-annual and decadal variability of sea surface temperature (SST) over Indian Ocean
Authors: KHOLE MEDHA 
Published: January 2022

With the discovery of a dipole in Indian Ocean Sea Surface Temperature (SST), the Indian Ocean has been gaining an increasing importance in the context of global climate. SST is one of the important oceanic parameters controlling the ocean climate. In view of this importance, an attempt has been made in this study to examine the inter-annual and inter-seasonal variability of SST over (i) Equatorial Indian Ocean (5° N - 5° S and 50° E - 100° E) and (ii) North Indian Ocean (5° N - 20° N and 50° E - 100° E), during the period 1961-98. The values of seasonal SST anomaly over these sectors of Indian Ocean are computed for the four standard meteorological seasons over India, viz., Winter (January - February), Pre-monsoon (March - May), SW Monsoon (June - September) and Post-Monsoon (October - December). The variability of seasonal SST anomaly is examined, using various standard statistical methods and procedures, on inter-annual as well as decadal time-scale and the results are inter-compared. The SST anomaly over both the above sectors of Indian Ocean, for all the four seasons, shows an increasing trend during 1961-98, more particularly and prominently, after mid-1970s.
A study on the role of synoptic and semi-permanent features of Indian summer monsoon on it’s rainfall variations during different phases of El-Nino
Authors: JENAMANI RAJENDRA KUMAR , DASH S. K. 
Published: January 2022

Characteristics of different synoptic and semi-permanent features of Indian Summer Monsoon Rainfall (ISMR), such as monsoon disturbances (lows and depressions), monsoon trough and Tibetan anticyclone and duration of monsoon, are studied individually for different phases of El-Nino during the period 1960-98 to understand why during some El-Nino single events, ISMR was deficient while during other years, ISMR was on the positive side of normal or normal. This study examines cases of El-Nino double events with deficient and near deficient ISMR in one of the two years and in both the years respectively. The cases of deficient ISMR without any El-Nino are also discussed. Emphasis has been given on the effects of the synoptic and semi-permanent features on spatial variations of ISMR.
Results show that characteristics of synoptic and semi-permanent features were important for ISMR and these were responsible for producing normal or above normal ISMR during some years in spite of El-Nino such as 1997. Also in the absence of El-Nino, ISMR was deficient because of less number of days of monsoon trough, lows and depressions, and weak Tibetan anticyclone. The reverse happened during flood years when there was no La-Nina. Statistical analysis indicates very high correlation coefficients (CCs) of these synoptic and semi-permanent features with ISMR than those of SST of Nino-3 region. India received highest monsoon rainfall during 1961 because total number of days of intense monsoon disturbances and monsoon trough and the total duration of monsoon over India during the year was the highest. This study shows that monsoon disturbances and monsoon trough are the most important components of synoptic and semi-permanent features, which affected spatial variation of ISMR in 1965 and 1966 with deficient rainfall and in 1961 and 1994 with excess rainfall over a large part of India.
Analisis Manajemen Pengelolaan Keuangan Dan Administrasi Di Mini Market
Authors: Safitri Marliza , Anwar US Kasful 
Published: January 2022

Determinan Kinerja Keuangan pada Minimarket “ Alfamart” di Kabupaten Karanganyar. Penelitian ini memiliki tujuan untuk mengetahui pengaruh catatan akuntansi, sistem akuntansi, aksesibilitas keuangan, innovasi keuangan, praktik penanganan uang tunai, biaya transaksi, akuntabilitas, transparansi, dan SPI terhadap kinerja keuangan pada minimarket “ alfamart” di Kabupaten Karanganyar. Populasi pada penelitian ini adalah seluruh karyawan minimarket “ alfamart” di Kabupaten Karanganyar berjumlah 44 minimarket. Sampel dipilih dari purposive sampling, sampel yang digunakan 10 minimarket yang beroperasional 24 jam (80 responden). Sumber data adalah data primer (kuesioner).
Analisis ini menggunakan analisis regresi linier berganda dengan program SPSS versi 21. Penelitian menunjukan bahwa catatan akuntansi, praktik penanganan uang tunai, biaya transaksi, dan akuntabilitas memiliki pengaruh terhadap kinerja keuangan. Sedangkan, sistem akuntansi, aksesibilitas keuangan, innovasi keuangan, transparansi, dan SPI tidak memiliki pengaruh terhadap kinerja keuangan.