bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model of hydrophobic porous media applied to stratified media: Water trapping, intermittent flow and fingering instability
Authors: Beltrame P. , Cajot F. 
Published: May 2022

Abstract
A macroscopic model of water infiltration is developed and applied to a stratified porous medium containing hydrophilic and hydrophobic layers. The governing equation is a gradient dynamics as in the Richards model but in which a wettability term replaces the suction pressure, taking into account the effective action of the hydrophobic matter. The resulting governing equation is a fourth-order PDE similar to the lubrication model or Cahn-Hilliard equations known to reproduce complex dynamics such as intermittency and fingering instability. The model makes it possible to simulate the finite spreading of water in horizontal directions when the porous medium is hydrophobic. Applied to a stratified medium alternating hydrophilic and hydrophobic layers, we highlight, depending on the mean water content, phenomena of water trapping in hydrophilic layers, intermittent flow and fingering instability. These regimes are studied using time integration bifurcation and numerical continuation tools.
Alignment of the cell long axis by unidirectional tension acts cooperatively with Wnt signalling to establish planar cell polarity
Authors: Hirano Sayuki , Mii Yusuke , Charras Guillaume , Michiue Tatsuo 
Published: May 2022

ABSTRACT
Planar cell polarity (PCP) is the aligned cell polarity within a tissue plane. Mechanical signals are known to act as a global cue for PCP, yet their exact role is still unclear. In this study, we focused on PCP in the posterior neuroectoderm of Xenopus laevis and investigated how mechanical signals regulate polarity. We reveal that the neuroectoderm is under a greater tension in the anterior-posterior direction and that perturbation of this tension causes PCP disappearance. We show that application of uniaxial stretch to explant tissues can control the orientation of PCP and that cells sense the tissue stretch indirectly through a change in their shape, rather than directly through detection of anisotropic tension. Furthermore, we reveal that PCP is most strongly established when the orientation of tissue stretch coincides with that of diffusion of locally expressed Wnt ligands, suggesting a cooperative relationship between these two PCP regulators.
Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis
Authors: Alam Sabrina Shameen , Kumar Shruti , Beauchamp Marie-Claude , Bareke Eric , Boucher Alexia , Nzirorera Nadine , Dong Yanchen , Padilla Reinnier , Zhang Si Jing , Majewski Jacek , Jerome-Majewska Loydie A. 
Published: May 2022

ABSTRACT
Heterozygous mutations in SNRPB, an essential core component of the five small ribonucleoprotein particles of the spliceosome, are responsible for cerebrocostomandibular syndrome (CCMS). We show that Snrpb heterozygous mouse embryos arrest shortly after implantation. Additionally, heterozygous deletion of Snrpb in the developing brain and neural crest cells models craniofacial malformations found in CCMS, and results in death shortly after birth. RNAseq analysis of mutant heads prior to morphological defects revealed increased exon skipping and intron retention in association with increased 5′ splice site strength. We found increased exon skipping in negative regulators of the P53 pathway, along with increased levels of nuclear P53 and P53 target genes. However, removing Trp53 in Snrpb heterozygous mutant neural crest cells did not completely rescue craniofacial development. We also found a small but significant increase in exon skipping of several transcripts required for head and midface development, including Smad2 and Rere. Furthermore, mutant embryos exhibited ectopic or missing expression of Fgf8 and Shh, which are required to coordinate face and brain development. Thus, we propose that mis-splicing of transcripts that regulate P53 activity and craniofacial-specific genes contributes to craniofacial malformations.
This article has an associated First Person interview with the first author of the paper.
VEGF-A controls the expression of its regulator of angiogenic functions, dopamine D2 receptor, on endothelial cells
Authors: Sarkar Chandrani , Chakroborty Debanjan , Goswami Sandeep , Fan Hao , Mo Xiaokui , Basu Sujit 
Published: May 2022

ABSTRACT
We have previously demonstrated significant upregulation of dopamine D2 (DAD2) receptor (DRD2) expression on tumor endothelial cells. The dopamine D2 receptors, upon activation, inhibit the proangiogenic actions of vascular endothelial growth factor-A (VEGF-A, also known as vascular permeability factor). Interestingly, unlike tumor endothelial cells, normal endothelial cells exhibit very low to no expression of dopamine D2 receptors. Here, for the first time, we demonstrate that through paracrine signaling, VEGF-A can control the expression of dopamine D2 receptors on endothelial cells via Krüppel-like factor 11 (KLF11)-extracellular signal-regulated kinase (ERK) 1/2 pathway. These results thus reveal a novel bidirectional communication between VEGF-A and DAD2 receptors.
The physiological cost of colour change: evidence, implications and mitigations
Authors: Alfakih Ateah , Watt Penelope J. , Nadeau Nicola J. 
Published: May 2022

ABSTRACT
Animals benefit from phenotypic plasticity in changing environments, but this can come at a cost. Colour change, used for camouflage, communication, thermoregulation and UV protection, represents one of the most common plastic traits in nature and is categorised as morphological or physiological depending on the mechanism and speed of the change. Colour change has been assumed to carry physiological costs, but current knowledge has not advanced beyond this basic assumption. The costs of changing colour will shape the evolution of colour change in animals, yet no coherent research has been conducted in this area, leaving a gap in our understanding. Therefore, in this Review, we examine the direct and indirect evidence of the physiological cost of colour change from the cellular to the population level, in animals that utilise chromatophores in colour change. Our Review concludes that the physiological costs result from either one or a combination of the processes of (i) production, (ii) translocation and (iii) maintenance of pigments within the colour-containing cells (chromatophores). In addition, both types of colour change (morphological and physiological) pose costs as they require energy for hormone production and neural signalling. Moreover, our Review upholds the hypothesis that, if repetitively used, rapid colour change (i.e. seconds–minutes) is more costly than slow colour change (days–weeks) given that rapidly colour-changing animals show mitigations, such as avoiding colour change when possible. We discuss the potential implications of this cost on colour change, behaviour and evolution of colour-changing animals, generating testable hypotheses and emphasising the need for future work to address this gap.
Rhodium-catalyzed C6-Selective Alkoxycarbonylation of Pyridones
Authors: Suzuki Hirotsugu , Ito Yuki , Matsuda Takanori 
Published: May 2022

Abstract
A novel method for the rhodium-catalyzed C6-selective alkoxycarbonylation of 2-pyridones is developed. This protocol offers a facile and direct synthetic route to 2-pyridone-6-carboxylates, for which C–H functionalization has never been realized. The reaction proceeds without the use of a stoichiometric additive and by using dialkyl dicarbonates as the alkoxycarbonyl source. The protocol can be successfully employed for a large-scale reaction.
Unleashing frugal innovation in private higher education institutions via intellectual capital and Information technology capability: a systematic literature review
Authors: Jayabalan Jayamalathi , Dorasamy Magiswary , Raman Murali , Sambasivan Murali , Harun Sharbani 
Published: May 2022

Background: Given the persistent challenges to the higher education business model, private higher education institutions (PHEIs) are exploring myriad ways to increase enrolment and income, while aggressively managing spending. Many PHEIs are facing financial distress and struggling because of decreasing budgets and declining revenue. Thus, carving unique strategies that direct the institution to focus on its core competencies, making additional budget cuts without compromising quality, developing new revenue streams, embracing new technology, and offering affordable programs, will ultimately lead to financial success. Frugal innovation (FI) can shed light on these challenges. Methods: This paper presents a systematic literature review to investigate and analyse prior research that focused on FI within the sphere of intellectual capital (IC) and information technology capabilities (ITC) research, and their relationships in PHEIs. Transfield’s five phases were employed to extract journal articles published over a thirty-year period (1990 to 2020) from major online databases using keyword searches. Although an initial search generated 76,025 papers, the search for IC and FI yielded 41 papers, and finally only two papers were selected as they clearly related IC with FI. Results: There was a research gap in the literature published from 1990 to 2020 regarding IC applications to achieve FI. This work revealed that IC and ITC research for FI in PHEI remain insufficiently explored. Conclusions: Further research is required on the evaluation model of IC, ITC and FI, methodologies, empirical analysis, and the development of measurement metrics. A limitation to this study is the number of keywords selected.
Implementing living evidence to inform health decisions: A strategy for building capacity in health sector (Protocol)
Authors: Rojas-Reyes María Ximena , Urrutia Chuchí Gerard , Rada Gabriel , Alonso Pablo , Rigau Comas David , Auladell-Rispau Ariadna 
Published: May 2022

Every day important healthcare decisions are made with incomplete or outdated information about the effects of the healthcare interventions available, what delivers the best value for the health system and where more research is needed. It is necessary to invest in strategies that allow access to reliable and updated evidence on which to base health decisions. The objective is to develop and evaluate a strategy for building the capacity among different actors of a country’s health system to implement the model known as “Living Evidence” [LE] in the evidence synthesis and dissemination of knowledge transfer [KT] products to inform health decisions. The study will involve professional members of health system organizations in charge of developing KT products to inform health decisions. The project will be developed in three complementary phases: 1) LE-implementation framework development through review of the literature, brainstorming meetings, user testing, and expert consultation; 2) training in LE tools and strategies; 3) developing LE synthesis for KT products by applying the framework to real-life diverse situations. To achieve the capacity-building strategy assessment goal, several surveys and interviews will take place during the process to assess: 1) the LE-implementation framework for the incorporation of LE synthesis in the development of KT products; 2) the training workshops; 3) the whole capacity-building strategy used for health system organizations be able of implementing the LE as part of the KT products they regularly produce. The expected results are an effective capacity-building strategy for health system organizations to implement the living evidence model in different KT products; a LE-implementation framework to be applicable to any country or region to incorporate LE in the KT products; LE synthesis for KT products directly applicable to the real-setting situations; integration of Epistemonikos-L.OVE platform for keeping the LE process in the development and updating of KT products.
Lost Marie Curies: Parental Impact on the Probability of Becoming an Inventor
Authors: Hoisl Karin , Kongsted Hans Christian , Mariani Myriam 
Published: May 2022

This research investigates the role of parents in explaining the surprisingly low presence of women among inventors despite their increase among graduates from science, technology, engineering and mathematics (STEM) subjects. With Danish registry data on the population born between 1966 and 1985 and an experimental setting crafted on siblings’ gender composition, we find that the transmission of inventorship from parents to children disfavors daughters if they have a (second-born) brother. We complement this analysis with evidence about the role of parental factors at different stages of children’s education. Overall, our results confirm that parental role models matter for children’s education, especially at early stages and, through this, increase the probability of a child’s becoming an inventor. However, the direct transmission of inventorship that favors boys much more than girls seems to be affected by gendered expectations developed by parents about daughters’ and sons’ returns from inventorship. Our study contributes to explaining who becomes an inventor and why by adding an important boundary condition to the literature: Parents are intermediaries who, based on their own interpretation of external information about inventive jobs, contribute to create or limit opportunities for their children. This paper was accepted by Olav Sorenson, organizations. Funding: The authors got financial funding from the Novo Nordisk Foundation in the course of the project “Investments, incentives, and the impact of Danish research (Triple-I-Research)” [Grant NNF16OC0021444]. Supplemental Material: Data files and the online appendix are available at https://doi.org/10.1287/mnsc.2022.4432 .
Public Opinion and Impression Management in the Communication of Performance During the Second Iraq War
Authors: Audia Pino G. , Rousseau Horacio E. , Stimmler Mary Kate 
Published: May 2022

Although studies show that organizations engaged in controversial actions often aim to minimize the release of threatening information, scholars know relatively little about what may prompt organizations to increase transparency in these situations. In this study, we focus on support from public opinion as a condition that may influence the disclosure of sensitive performance information to the public. Using the second Iraq War as an empirical context, we focus on the extent to which public officials—Pentagon spokespersons—release and frame information about war performance. This outcome is critical because the way in which organizations communicate their performance to outsiders has often been regarded as a key defensive impression management tactic. We hypothesize that high public support for the war will increase the likelihood that Pentagon officials release information about sensitive combat performance indicators in their press briefings and identify contingencies, such as adversity and organizational spokespersons’ power, that moderate this relationship. We also explore whether high public support decreases the strategic use of alternate performance frames that emphasize metrics that signal progress toward a desirable end state. Using a unique data set based on the coding of press briefings, public opinion data, and other public sources, we find support for several of our hypotheses. We discuss implications for understanding the relationship between public opinion and impression management and highlight the importance of extending this research to nongovernmental organizations. Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2022.1598 .
EDUKASI MENOPAUSE DAN ANDROPAUSE GUNA MEWUJUDKAN LANSIA SEHAT DAN PRODUKTIF DI KELURAHAN COKRODININGRATAN KECAMATAN JETIS YOGYAKARTA
Authors: Utami Fitriana Putri , Udin Rizaldy , Pratama Risqi Fitriyadi Rizal , Nugroho Aditya 
Published: May 2022

Peningkatan Usia Harapan Hidup (UHH) diproyeksikan akan terus berlangsung, sehingga mengakibatkan peningkatan jumlah orang lanjut usia (lansia) pada masa mendatang. Masa lanjut usia ditandai dengan adanya menopause pada seorang wanita dan andropause pada pria. Masa ini sering disertai dengan adanya keluhan atau gangguan yang dapat mengganggu aktivitas sehari-hari. Keluhan-keluhan tersebut dapat diatasi dengan adanya persiapan fisik dan psikis menjelang lansia. Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan informasi mengenai menopause dan andropause bagi lansia dan pra-lansia di RW 03, 04, dan 05 di Kelurahan Cokrodiningratan, Kec. Jetis, Kota Yogyakarta yang dilaksanakan selama tiga hari pada bulan November 2019, menggunakan metode penyuluhan dan tanya jawab.Â Hasil dari kegiatan edukasi ini terlihat peserta kegiatan antusias dalam bertanya tentang materi yang disampaikan dan aktif menceritakan kisah mereka saat awal memasuki masa menopause dan andropause. Reaksi seseorang berupa suka atau tidak suka pada materi yang diterima merupakan faktor yang memegang peranan penting dalam pembentukan sikap akibat adanya kegiatan pendidikan dan pelatihan.
UPAYA PENCEGAHAN PENYAKIT YANG DISEBABKAN OLEH TIKUS DI RT 05 DAN 06 DUSUN PRINGGOLAYAN, BANGUNTAPAN BANTUL, D.I YOGYAKARTA
Authors: Parisudha Annisa Parisudha , Jannah Arihni Arihatal , Apriani Dewi , Puspitarini Elsa Nurdyah , Faatihah Utari Esi , Wijayanti Riana Dyah 
Published: May 2022

Penyakit yang disebabkan oleh tikus menjadi kekhawatiran tersendiri di wilayah pemukiman penduduk heterogen dan juga padat. Upaya pencegahan dilakukan melalui program penyuluhan yang bertujuan untuk mengantisipasi terjadinya penyakit yang tidak diharapkan yang dapat dibawa oleh tikus. Metode program penyuluhan dilakukan melalui media banner yang berisikan kiat-kiat yang dapat dilakukan oleh masyarakat untuk mencegah terjadinya penyakit yang disebabkan oleh tikus. Dampak dari program yang dilakukan diketahui adanya kesadaran masyarakat yang muncul untuk berupaya menjalankan pesan-pesan yang tercantum didalam banner.Â Â
ASPEK KESELAMATAN DAN KESEHATAN KERJA PADA FASILITAS PELAYANAN KESEHATAN DI INSTANSI KESEHATAN WILAYAH KERJA PUSKESMAS BANGUNTAPAN III
Authors: Rifai Muchamad , Winanto Yokas Siswan , Maâ€™rifah Ulil , Asri Inaya Larang , Safitri Rizqi Nur Anis , Azmi Nur 
Published: May 2022

Keselamatan dan kesehatan kerja di fasilitas pelayanan kesehatan merupakan salah satu upaya perlindungan terhadap tenaga kerja. Pada beberapa instansi kesehatan yang berada di wilayah kerja Puskesmas Banguntapan III, masih ditemukan beberapa permasalahan seperti penggunaan Alat Pelindung Diri (APD) dalam bekerja yang tidak lengkap serta tidak adanya media promosi keselamatan dan kesehatan kerja.Â Masih kurangnya pengetahuan tentang pentingnya penerapan budaya keselamatan dan kesehatan kerja di beberapa instansi kesehatan membuat para pekerja tidak begitu memperhatikan aspek tersebut dan dapat menyebabkan terjadinya kecelakaan kerja. Untuk menanggulangi hal tersebut dilakukan intervensi ke beberapa instansi kesehatan. Tujuannya yaitu untuk meningkatkan pengetahuan pekerja tentang keselamatan dan kesehatan kerja di fasilitas pelayanan kesehatan, serta mengurangi risiko terjadinya kecelakaan kerja di tempat kerja. Metode yang digunakan yaitu pemberian Â media promosi keselamatan dan kesehatan kerja berupa poster dan leaflet, serta penyuluhan yang dilaksanakan dari tanggal 29 Januari sampai 27 Februari 2020. Hasil dari kegiatan tersebut yaitu pekerja menerima poster untuk dipasang di dinding dan leaflet untuk mereka baca, dan selainÂ itu pekerja memiliki pengetahuan yang belum mereka ketahui sebelumnya tentang Keselamatan dan Kesehatan Kerja. Dampak program ini adalah pekerja telah sadar menggunakan APD dengan lengkap ketika bekerja.
PENINGKATAN PENGETAHUAN RUMAH SEHAT DENGAN METODE CERAMAH DAN LEAFLET DI DUSUN MODALAN
Authors: Sukesi Tri Wahyuni , Maurizka Isna Rahma , Pratiwi Ratih Dian , Kahar Mir Vindahati , Sari Dyah Ayu Puspita , Indriani Nur Safani , Santi Santi 
Published: May 2022

Rumah merupakan lingkungan yang paling dekat masyarakat. Rumah yang tidak sehat dapat menimbulkan permasalahan-permasalahan kesehatan bagi penghuninya. Dusun Modalan Desa Banguntapan RT 8 dan RT 9 masih terdapat rumah yang belum memenuhi kriteria rumah sehat. Tujuan dari pengabdian kepada masyarakat ini adalah memberikan edukasi kepada masyarakat mengenai rumah sehat untuk meningkatkan kesehatan rumah sehingga penyakit berbasis lingkungan rumah dapat dikurangi. Metode yang digunakan dalam kegiatan penyuluhan pada pengabdian masyarakat ini yaitu dengan ceramah dan leaflet. Materi yang disajikan berkaitan dengan rumah sehat seperti indikator rumah sehat dan penyakit yang ditimbulkan bila rumah tidak sehat. Pembagian leaflet kepada peserta yang hadir pada saat intervensi terdiri dari tiga tema yaitu rumah sehat, sumber air bersih dan lima pilar Sanitasi Total Berbasis Masyarakat (STBM). Sasaran kegiatan pengabdian ini adalah warga masyarakat di Â Dusun Modalan. Kegiatan pengabdian kepada masyarakat berjalan dengan lancar, masyarakat memberikan respon yang positif terhadap kegiatan yang dilaksanakan. Masyarakat berpartisipasi aktif dalam setiap rangkaian kegiatan pengabdian kepada masyarakat ini.
Postsecondary Success Stories: Perspectives of Adults With Intellectual and Developmental Disabilities
Authors: Brendli Katherine R. , Kozachuk Lindsay 
Published: May 2022

Abstract
The Individuals With Disabilities Education Act (IDEA) of 2004 highlights the need for special education and related personnel to prepare youth with disabilities for adulthood, particularly in the areas of postsecondary education, employment, and independent living. In accordance with this policy, our study used qualitative case reporting to examine the personal perspectives of three adults with IDD in the outcome domains outlined by the IDEA. Using positive psychology and self-determination theories, we sought to better understand the diverse factors that contributed to the participants' “successes” in these areas. Results revealed a series of evidence-based predictors of success contributed to overcoming challenges to employment, postsecondary education, and independent living for participants. Implications for research, policy, and practice are discussed.
Multifunctional tunable visible light metalens based on double-layer barium titanate
Authors: Lv Shuyuan , Wang Rong , Luo Wenfeng , Bai Yuchi , Meng Fei 
Published: May 2022

A tunable metalens plays an indispensable role in the development of integrated optics, multi-imaging systems, etc. We propose a multifunctional tunable metalens that combines a double-layer barium titanate (BTO) structure and geometric phase in the visible light band. The refractive indices of the upper and lower layer BTO nanorods can be tuned continuously and independently by applying external voltage (0–60 V), and the lower layer can be converted between a full-wave plate and normal scattering unit, while the scatterers of the upper layer can be switched between a half-wave plate and full-wave plate. The voltages of the upper and lower layers can be adjusted to achieve different functions such as optical switches, conversion between monofocal and bifocal metalenses, adjustment of bifocal intensity, and broadband focusing (585–690 nm). Simulation results show that the multifunctional tunable metalens has a good focusing effect. A metalens with high focusing efficiency, dynamic reconfigurability, and a switching function has tremendous application potential in the fields of multifunctional devices, biomedicine, optical communication, imaging, and so on.