bluuebunny/crossref_metadata_2025_split huggingface dataset:
The kids are alright: adolescents’ experiences during COVID-19 disruption
Authors: Lopatovska Irene , Garg Radhika , Turpin Olivia , Yoon Ji Hee , Vroom Laura , Brown Diedre 
Published: May 2022

Purpose
This study aimed to understand adolescents’ experiences, negative feelings and coping mechanisms associated with the major disruption caused by the COVID-19 pandemic. The purpose of this study was to develop a baseline for understanding adolescents and their environment to assist future developments of technological and other solutions to mitigate adolescents’ loneliness, improve their wellbeing and strengthen their resilience.

Design/methodology/approach
The data about adolescents’ experiences during the COVID-19 pandemic was collected through virtual interviews conducted via Zoom. A total of 39 adolescents (aged 12 through 18 years) primarily from the North East of the USA participated in the study. The transcripts of the interviews were analyzed using thematic analysis.

Findings
This study found evidence of negative disruptions to adolescents’ social, learning and emotional routines. This study also found that in dealing with the effects of COVID-19 disruption, most of the participants exhibited five key attributes of individual resilience, including social competence, problem-solving, critical consciousness, autonomy and a sense of purpose. External factors supporting resilience were also mentioned, including technology resources, family, school and broader community.

Originality/value
This study relied on first-hand adolescents’ reports of their experiences, feelings and coping strategies during the pandemic. This study applied a resilience framework to interpret the findings and translate them into recommendations for further development of support systems for adolescents.
Doing business with Asia: the case for Asian business studies engagement in Australian universities
Authors: Cullen Anne , McCornac Dennis 
Published: May 2022

Purpose
This paper aims to explore the two main viewpoints on Australia’s relationship with Asia; first, the highly visible informed pro-Asia protagonists, and second, pervasive public opinion as informed by history and the Australian self-image. The purpose is to present the polemic internal to Asian Studies and Business Schools currently. This paper postulates that only an (uncomfortable) whole-of-sector introspection would result in an authentic national narrative to drive mutual respect and business between Asia and Australia.

Design/methodology/approach
The current dismembering of Asian Studies degrees and Asian Business specialisations at Australian universities indicates a waning national support to the production of Asian specialists able to link the Australian economy into the advancing Asian commercial dominance. But such an assessment would not be completely accurate. The authors argue that as an important component of Asian business and economics, understanding the current situation is vital to breathing life back into the Asian Studies and Asian Business Studies disciplines at Australian national universities.

Findings
This paper concludes that the responsibility for creating specialists should fall to the university sector but is currently defaulting to the business sector. This paper proposes that business schools need to be more active participants in Asian engagement strategies. Thus, Australian universities and disciplines such as Asian Studies and Asian Business must have the academic will and the business support to take up a major role in positive evolution of the Eurocentric elements that currently hold back meaningful engagement.

Originality/value
This is a current issue that needs to be addressed.
Reassessing research on marketing channel strategies in the internet era: opportunities, challenges, and responses
Authors: Liu Yi , Zhang Hengyuan 
Published: May 2022

PurposeChinese marketing scholars have been studying marketing channel strategies for the past 20 years. However, the emergence of the internet and the digital economy has led to new marketing channels and practices that question the usefulness of this existing body of research, challenging Chinese marketing scholars specialized in channel strategy who are limited by path-dependent foundations and methods. This article reviews the research on marketing channel strategies by Chinese scholars, identifies the challenges posed by new channels and practices, and proposes some strategies for addressing these challenges.Design/methodology/approachThis study systematically summarizes the research on marketing channel strategies published by Chinese scholars in English or Chinese in the past 20 years. Including articles published in either English-language or Chinese-language marketing journals allows this review to summarize the overall current state of marketing channel strategy research.FindingsThe theory and research methods used in studies of marketing channel strategies are relatively mature, and the field is saturated. However, the development of e-commerce and online channels have changed the structure of offline marketing channels, making Chinese scholars of marketing channel strategies to necessarily change Chinese scholars' thinking, methods, and research topics. Scholars from the fields of e-commerce, information system management, and big data are now conducting research on marketing channels. Chinese scholars who study marketing channel strategies need to establish and develop novel approaches to researching these new phenomena and practices.Originality/valueThis article analyzes the challenges faced by Chinese scholars who study marketing channel strategies and provides suggestions for future research in the area. The findings will assist in the development of research on new online and offline channel phenomena in the era of the internet and the digital economy.
Expert judgments versus publication-based metrics: do the two methods produce identical results in measuring academic reputation?
Authors: Guba Katerina , Tsivinskaya Angelika 
Published: May 2022

PurposeThis study aims to assess the validity of citation metrics based on the disciplinary representative survey.Design/methodology/approachThe present project compared citation rankings for individual scientists with expert judgments collected through a survey of 818 Russian sociologists. The Russian Index of Science Citation was used to construct the general population of 3,689 Russian sociologists, to whom the survey was sent by email. The regression analyses of bibliometric indicators and peer review scores for 723 names of scholars mentioned in the survey have been undertaken.FindingsFindings suggest that scientometric indicators predict with significant accuracy the names of the most influential sociologists and those scholars who are not mentioned while they are less relevant for prediction names which received moderate attention in the survey.Originality/valueThis study contributes to the research on the validity of citation metrics by focusing on scientometric indicators, not limited to traditional metrics but including non-standard publication metrics and indicators of potential metric abuse. Besides, the study presents the national bibliometric data source that is especially important for non-Western higher education systems, less presented in the Web of Science or Scopus.
The influence of female agentic and communal leadership on work engagement: vigour, dedication and absorption
Authors: Dunlop Robyn , Scheepers Caren Brenda 
Published: May 2022

Purpose
The purpose of this study is investigating the influence of leadership on work engagement. The definition of leadership is primarily couched in culturally masculine terms (and known as an agentic leadership style) that disfavours women, who are often perceived as being communal leaders who are compassionate and humble. The research gap addressed is whether communal and agentic leadership styles of female leaders have positive associations with work engagement.

Design/methodology/approach
A quantitative study was undertaken by applying purposive non-probability sampling and using an online survey with screening questions to ensure the respondent reported to a senior female manager. The survey consisted of reliable and valid Likert scales: agentic and communal leadership styles were assessed using the Agency-Communion-Inventory (AC-IN) scale with 20 questions and the Utrecht Work Engagement Scale (UWES-9) with three sub-scales: vigour, dedication and absorption. The 153 usable responses in this study were used to conduct validity and reliability tests and to apply multiple regression to test associations.

Findings
Both agentic and communal leadership have a positive impact on work engagement when exhibited by a female. Although agentic leadership had an influence on all the elements of work engagement, communal leadership had a far stronger impact.

Originality/value
Female managers with communal leadership styles need to realise that they have more influence on their employees’ emotional, physical and cognitive connections to their work than female managers with agentic leadership styles. Those with agentic leadership styles need to exhibit a communal style as well, so as to enhance the influence they have on their employees’ work engagement.
One foot on shore: An analysis of global millionaires' demand for U.S. investor visas
Authors: Harpaz Yossi 
Published: May 2022

AbstractEach year, around 10,000 foreigners obtain a U.S. residence visa after investing half a million dollars or more. Who are the millionaires that acquire these visas and what motivates them to leave their home countries? To answer this question, I analyzed an original data set that combines U.S. visa statistics with data on global millionaire populations. The analysis produced three key findings. First, demand for investor visas was led by millionaires from countries that ranked lower in the global hierarchy of citizenship value. Second, most of the visas were acquired by Chinese millionaires, who recorded the world's highest application rate. Third, when the quality of democracy in a country declined, visa applications surged. These findings suggest that investor visas are used by elites in less developed countries to hedge against the risks associated with authoritarian rule. Such elites perceive investor visas as a foothold in a stable and democratic country that can provide an insurance policy or exit option.
Efficacy of different sequential patterns after crizotinib progression in advanced anaplastic lymphoma kinase‐positive non–small cell lung cancer
Authors: Ma Xiya , Yang Shaoxing , Zhang Kun , Xu Jing , Lv Panpan , Gao Hongjun , Qin Haifeng , Wang Hong , Liu Xiaoqing 
Published: May 2022

AbstractBackgroundThe efficacy difference between the second‐ and third‐generation of anaplastic lymphoma kinase‐tyrosine kinase inhibitors (ALK‐TKIs) after crizotinib failure in advanced ALK‐positive non–small cell lung cancer (NSCLC) has not been clarified. This study evaluates the efficacy of different sequential patterns after crizotinib progression.MethodsData of patients who met the study criteria were retrospectively analyzed. The Kaplan–Meier method was used to draw survival curves, log‐rank method was used to compare the differences between groups, and Cox multivariate analysis was used to evaluate the significance of influencing factors.ResultsA total of 128 patients developed disease progression after crizotinib. The overall survival (OS) of 57 patients in the sequential second‐generation ALK‐TKIs group was significantly longer than that of 65 patients with other systemic treatment (58.5 months vs. 33.0 months, p < 0.001); The OS of the direct sequential lorlatinib group was significantly longer than the second‐generation ALK‐TKIs group (114.0 months vs. 58.5 months, p = 0.020). Similarly, of the 48 patients who developed disease progression after first‐ and second‐generation ALK‐TKIs treatment, 16 patients with sequential lorlatinib had significantly longer OS than the others (62.0 months vs. 43.0 months, p = 0.014). The progression‐free survival (PFS) of second‐line and third‐ or later‐line lorlatinib were statistically different (20.0 months vs. 5.5 months, p = 0.011).ConclusionsThe application of next‐generation ALK‐TKIs after crizotinib progression significantly prolonged survival, whereas direct sequencing lorlatinib seemed advantageous. Similarly, lorlatinib also prolonged survival in patients with first‐ and second‐generation ALK‐TKIs failure.
Experiences of informal caregiving among older lesbian and gay adults in Australia
Authors: Waling Andrea , Lyons Anthony , Alba Beatrice , Minichiello Victor , Barrett Catherine , Hughes Mark , Fredriksen‐Goldsen Karen , Edmonds Samantha , Bath Nicky 
Published: May 2022

AbstractObjectiveThis study examined older lesbian and gay adults' experiences regarding informal caregiving, including challenges and positive aspects of caregiving.MethodsInterviews were conducted with 16 lesbian women and gay men in Australia, aged 60+, who were engaged in informal caregiving. Analyses involved a qualitative thematic approach.ResultsMost participants were caring for a friend or partner and regarded caregiving as a form of love and did not seek external support despite noting several impacts. Some participants found that they too were beginning to require care. For some, formal care was being considered, but with a degree of reluctance.ConclusionsOlder lesbian and gay adult caregivers experience a range of challenges and support needs in relation to their experiences with the caregiving role. This research highlights a need for ensuring that caregiving policies and practices be responsive to the experiences and challenges faced by older lesbian and gay people.
Effectiveness and safety of vedolizumab in a matched cohort of elderly and nonelderly patients with inflammatory bowel disease: the IG‐IBD LIVE study
Authors: Pugliese Daniela , Privitera Giuseppe , Crispino Federica , Mezzina Nicolò , Castiglione Fabiana , Fiorino Gionata , Laterza Lucrezia , Viola Anna , Bertani Lorenzo , Caprioli Flavio , Cappello Maria , Barberio Brigida , Ricci Chiara , Balestrieri Paola , Daperno Marco , Pluchino Dario , Rizzello Fernando , Scribano Maria Lia , Sablich Renato , Pastorelli Luca , Manguso Francesco , Variola Angela , Di Sario Antonio , Grossi Laurino , Armuzzi Alessandro ,   IG‐IBD LIVE Study Group
Published: May 2022

SummaryBackgroundVedolizumab registration trials were the first to include elderly patients with moderate‐to‐severe ulcerative colitis (UC) or Crohn’s disease (CD), but few real‐life data have been reported in this population.AimsWe investigated the effectiveness and safety of vedolizumab in matched cohorts of elderly and nonelderly UC and CD patients.MethodsThe Long‐term Italian Vedolizumab Effectiveness (LIVE) study is a retrospective‐prospective study including UC and CD patients who started vedolizumab from April 2016 to June 2017. Elderly patients (≥65 years) were matched clinically 1:2 to nonelderly patients (18–64 years); the 2 groups were followed until drug discontinuation or June 2019.ResultsThe study included 198 elderly (108 UC, 90 CD) and 396 matched nonelderly patients (205 UC, 191 CD). Nonelderly UC patients had a significantly higher persistence on vedolizumab compared to elderly patients (67.6% vs. 51.4%, p = 0.02). No significant difference in effectiveness was observed between elderly and nonelderly CD patients (59.4% vs. 52.4%, p = 0.32). Age ≥65 years was associated with lower persistence in UC; for CD, previous exposure to anti‐TNF‐α agents, Charlson comorbidity index >2 and moderate‐to‐severe clinical activity at baseline were associated with lower persistence. There were recorded 130 adverse events, with comparable rates between the two groups. A Charlson comorbidity index >2 was associated with an increased risk of adverse events.ConclusionVedolizumab can be considered a safe option in elderly IBD patients. Its effectiveness in elderly UC patients may be reduced, while no age‐dependent effect on effectiveness was observed in CD.
A detailed analysis of expedited regulatory review time of marketing authorization applications for new anticancer drugs in the US and EU
Authors: da Costa Gonçalves Fabiany , Demirci Ebru , Zwiers Alex 
Published: May 2022

AbstractThe aim of this study was to assess the effect of expedited regulatory approval programs used by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA), type of product (small molecule or biotechnology‐derived product) and consulting scientific advisory committees on the regulatory review time of the marketing authorization applications (MAAs) for new anticancer drugs. A dataset composed of 76 new anticancer drugs was constructed. The date of submission of the MAAs in the United States and the European Union were comparable. The typical review time of MAAs was 136 days shorter in the United States (201 days [median]) than in the European Union (337 days [median]). The type of product did not have a high impact on the review time. The review time of the MAAs for drugs undergoing priority review in the United States or accelerated assessment in the European Union at the stage of review of MAA was generally shorter than that for drugs following the standard regulatory pathway. The regulatory pathway using at least one expedited regulatory program at the stages of drug development, review of MAA, and approval of drug in the United States (172 days [median]), and that at the stages of review of MAA and approval of drug in the European Union (183 days [median]) enabled the shortest review time of MAAs. Referral to advisory committee meeting increased the review time of MAAs for drugs undergoing one or more expedited regulatory approval programs in the United States and the European Union close to that for drugs undergoing the standard regulatory approval pathway.
Limited behavioral flexibility in oviposition behavior for the invasive fly Zaprionus indianus
Authors: Gramenos Irina Andrea , Soto Eduardo María , Lavagnino Nicolás José 
Published: May 2022

AbstractZaprionus indianus Gupta (Diptera: Drosophilidae) is a fly species native to the Afrotropical biogeographic region that expanded its geographical distribution to the American continent around 1999. This fly lays eggs, feeds, and develops on a wide variety of fruits colonized by yeasts and bacteria, as well as on ripe, non‐damaged soft‐skinned fruits. The arrival of Z. indianus to American ecosystems entails co‐existence with other drosophilid species with the same resource specificity, such as the cosmopolitan human commensal Drosophila melanogaster Meigen. In this scenario, the oviposition strategy could be relevant for invasion success in terms of partitioning the utilization of resources in space or time. We investigated whether Z. indianus avoids laying eggs in resources previously used by another species (D. melanogaster), or whether oviposition is unaffected by the presence of other species’ larvae. Results show a stable oviposition behavior of Z. indianus, considering that this fly lays the same number of eggs regardless of whether the oviposition resource has larvae of other species, whereas D. melanogaster showed a flexible oviposition behavior when presented with the same oviposition resources. Zaprionus indianus being a good larval competitor against other drosophilids, this stable oviposition strategy could be positive for invasiveness as it ensures a continuous spread of eggs and subsequent larval development during invasion in new and heterogeneous ecosystems.
Worth the paper they are printed on? Findings from an independent evaluation of the understandability of patient information leaflets for antiseizure medications
Authors: Noble Adam J. , Haddad Sara , Coleman Niamh , Marson Anthony G. 
Published: May 2022

AbstractObjectiveThe Patient Information Leaflet (PIL) is an authoritative document that all people with epilepsy in the EU receive when prescribed antiseizure medication (ASM). We undertook the first independent, comprehensive assessment to determine how understandable they are. Regulators state that when patients are asked comprehension questions about them, ≥80% should answer correctly. Also, recommended is that PILs have a maximum reading requirement of US grade 8.MethodsStudy 1: We obtained 140 current ASM PILs written in English. "Readability" was assessed using four tests, with and without adjustment for influence of familiar, polysyllabic words. A total of 179 online materials on epilepsy were also assessed.Study 2: Two PILs from Study 1 were randomly selected (Pregabalin Focus; Inovelon) and shown to 35 people from the UK epilepsy population. Their comprehension was assessed.Study 3: To understand whether the student population provides an accessible alternative population for future examination of ASM PILs, Study 3 was completed, using the same methods as Study 2, except that participants were 262 UK university students.ResultsStudy 1: No PIL had a reading level of grade 8. Median was grade 11. Adjusting for context, the PILs were still at grade 10.5. PILs for branded ASMs were most readable. PILs were no more readable than (unregulated) online materials.Study 2: Users struggled to comprehend the PILs' key messages. The eight questions asked about pregabalin were typically answered correctly by 54%. For Inovelon, it was 62%.Study 3: Most student participants comprehended the PILs' key messages. The questions about Inovelon were answered correctly by 90%; for pregabalin it was 86%.SignificanceThis is the first independent and comprehensive examination of ASM PILs. It found that PILs being used fail to meet recommendations and regulatory requirements and risk not being understandable to a substantial proportion of users. In finding that people from the epilepsy population differ markedly in comprehension of PILs compared to students, this study highlights the importance of completing user testing with the target population.
5‐ALA loaded self‐adhesive patch‐PDT is effective and safe in the treatment of actinic keratoses on hands and arms
Authors: Bai‐Habelski Jon Chim , Ko Annette , Ortland Christoph , Stocker Marcus , Ebeling Andrea , Reinhold Uwe 
Published: May 2022

AbstractPhotodynamic therapy (PDT) with 5‐aminolevulinic acid hydrochloride (ALA) is an established method for the management of AK. PD P 506 A (brand name Alacare®) is an approved medicinal product for the treatment of AK located on scalp and face. It is a self‐adhesive, light‐proof patch loaded with 5‐ALA HCl and was developed for easy handling. AK located on arms, hands or trunk do not respond as well to ALA‐PDT as AK lesions on the head do. It has been reported that occlusion during ALA incubation can improve clinical outcome after ALA‐PDT for AK on hands and arms. We present the results of a first explorative pilot study involving 20 participants with a total of 145 treated (122 evaluable) AK lesions. The trial investigated the conduct of two ALA‐PDTs within 1–2 weeks and involved all severity grades of AK. The model‐based percentage of complete clearance on lesion‐basis was estimated being 78.0% (95%‐CI: [64.6%, 87.3%]), and the by‐participant calculation (patient‐based clearance) led to similar results (78.7% with a 95%‐CI of [67.0%, 90.3%]). The treatment was well tolerated. Local reactions during ALA patch incubation were rare whereas nearly all patients showed the expected reactions during or after the illumination, primarily erythema and pain. The study results indicate that two PD P 506 A‐PDT sessions 1–2 weeks apart are an efficacious treatment for AK on hands and arms. Especially mild but also moderate lesions responded very well to PDT treatment involving ALA incubation under occlusion.