bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRPA1 deficiency attenuates cardiac fibrosis via regulating GRK5/NFAT signaling in diabetic rats
Authors: Zhao Mengmeng , Zheng Zihui , Xu Yao , Zhang Jishou , Pan Wei , Yin Zheng , Liu Jianfang , Xu Shuwan , Wei Cheng , Wan Jun , Wang Menglong 
Published: August 2022

AbstractDiabetic cardiac fibrosis increases ventricular stiffness and promotes diastolic dysfunction. The transient receptor potential ankyrin 1 (TRPA1) has been reported to be associated with the occurrence and development of various cardiovascular diseases. However, the role of sperm TRPA1 in diabetic cardiomyopathy (DCM) remains unclear. Here, we investigated the cardioprotective effects of TRPA1 deficiency on DCM in streptozotocin (STZ)-induced diabetic rats and in neonatal rat cardiac fibroblasts (CFs) incubated with high glucose (HG). The results showed that the expression of TRPA1 was increased in the cardiac tissue of diabetic rats and in CFs treated with HG. TRPA1 deficiency significantly ameliorated cardiac dysfunction in diabetic rats, characterized by improved echocardiography and reduced cardiac hypertrophy and fibrosis. In vitro, TRPA1 deficiency suppressed HG-induced activation and transdifferentiation of CFs. Mechanistically, the cardioprotective effect of TRPA1 deficiency inhibited cardiac fibrosis by regulating GRK5/NFAT signaling. Furthermore, inhibition of GRK5/NFAT signaling abolished TRPA1 activation-induced transdifferentiation of CFs. For further clinical translation, we utilized 1,8-cineole (CIN), a natural inhibitor of TRPA1, to treat DCM. Inhibition of TRPA1 activation by CIN attenuated cardiac dysfunction and remodeling in diabetic rats by regulating GRK5/NFAT signaling. Taken together, these results suggest that TRPA1 deletion protects against DCM in vivo and in vitro by regulating GRK5/NFAT signaling. TRPA1 inhibitor CIN may serve as novel therapeutic agents for the treatment of DCM.
A novel MDM2-p53 antagonist APG115 exerts synergistic effect with ibrutinib via targeting MCL-1 in chronic lymphocytic leukemia
Authors: Han Yang , Hu Xinting , Wang Hua , Tian Zheng , Zhang Xin , Hu Shunfeng , Zhang Ya , Wang Xin 
Published: August 2022

Abstract
APG115 is a highly selective small-molecule inhibitor of MDM2-p53 interaction with oral activity, which restores p53 activation in patients with solid tumors in clinical trials. The Bruton tyrosine kinase inhibitor (BTKi) ibrutinib exhibits significant efficacy in chronic lymphocytic leukemia (CLL) patients including high-risk patients. However, the chemoresistance of ibrutinib still needs to be addressed urgently. Herein, we first demonstrated that the APG115 exerted apoptogenic and antiproliferative effects, and induced G0/G1 cell cycle arrest in CLL. As an agent used either alone or in combination with ibrutinib together, APG115 provided remarkable antitumor activity and overall survival extension in vivo. Mechanistically, the activation of p53 positively regulates the p53/p21 pathway, prompting MCL-1 degradation via inducing its ubiquitination. On basis of the upregulation of MCL-1 in CLL cells with ibrutinib resistance, these evidences explain how APG115 reduces the resistance of ibrutinib in CLL. This study offers promising prospects to constitute effective regimens of APG115 combined with ibrutinib for the CLL treatment.
Investigating the intensity of the X-ray beam reflected from a single crystal of ammonium dihydrogen phosphate (ADP) due to X-ray transfer from the transmission to reflection direction under a temperature gradient
Authors: DEZFOULI MEHDI GHANAD , TROUNI KARAPET 
Published: August 2022

Abstract
This paper investigates the phenomenon of X-ray radiation transfer from the direction of transmission to the reflection direction in Laue geometry from the atomic planes of a single crystal of ammonium dihydrogen phosphate (ADP) under the influence of a temperature gradient. The experiment results demonstrated that as the temperature gradient increases, the reflection intensity increases uniformly by more than 11 times. This phenomenon has been described using an asymptotic solution based on the dynamical X-ray diffraction in crystals with weak deformation. At low-temperature gradients, theoretical and experimental results were in good agreement.
The protective properties of resveratrol on lactate dehydrogenase activity in toluene exposed rats
Authors: Dere Egemen , Tuna Gonca , Arfaoui Aboush El 
Published: August 2022

Abstract
Toluene is an aromatic hydrocarbon found in nature mainly in crude oil. Since it is a good solvent and has less toxic effects, it is preferred to be used instead of benzene in the industry. Toluene causes damage to the lungs and nervous system by contaminating chronically or acutely, especially through the respiratory tract. Resveratrol (RES) which is found in many fruits, especially grapes, provides antioxidant support to the body and shows protective properties against harmful substances. The aim of this study is to examine the negative effects of toluene on lactate dehydrogenase (LDH) activity in blood, liver and muscle tissue and to investigate the protective effects of RES against toluene. In the study, rats were divided into two groups as control and experimental groups. The first experimental group was injected with toluene at a dose of 900mg/kg intraperitoneally for 6 days. While the 2nd experimental group was given the same dose of toluene and 5mg/kg RES, the 3rd experimental group was given the same dose of toluene with 10mg/kg RES, the 4th experimental group was given the same dose of toluene and 20mg/kg RES. In the study two control groups, serum physiological and ethanol control groups, were used. After 6 days, all rats were killed by cervical dislocation. Blood, liver and muscle tissues were rapidly extracted from rats. LDH activities were determined. As a result, it was seen that toluene increased LDH activity and RES played a regulatory role in LDH activity.
Policy Linkage of Governments in Air Pollution Control: An Empirical Analysis Based on China's Policy Texts
Authors: Zhang Peide , Lin Zhongguo , Peng Binbin , Du Huibin 
Published: August 2022

Abstract
Understanding the multisectoral and multiregional cooperation which coordinates the relationship between different government actors and integrates their policies is essential to effectively address increasing regional air pollution. Although the literature on effects of polices is rapidly expanding, little is known about the actual extent of policy linkage of multisector and multiregion, resulting in policy conflicts and duplications. Using 13486 policy documents in China from 2000 to 2018, we combine machine learning methods with social network analysis to investigate the policy content and linkage in central departments and local departments. We find that, firstly, the coordination of central departments is constantly improving, mainly focusing on the Comprehensive Control and the Publicity Guide, with little attention to market-oriented measures. Secondly, since local governments have similar policy foundations in Emergency Management, Total Amount Control, Dust Control, and Moving Pollution Control, they are able to cooperate in these aspects, even when there are differences in local regulations. This paper provides suggestions for the further coordination of the central government, as well as the direction of policy integration for local governments.
Differential response of growth and C:N:P stoichiometry to Si supply between bamboo and other tree seedlings
Authors: Liu Xiaoyu , Tang Xinghao , Compson Zacchaeus G. , Huang Dongmei , Zou Guiwu , Luan Fenggang , Song Qingni , Fang Xiong , Yang Qingpei , Liu Jun 
Published: August 2022

Abstract
AimsSilicon (Si), while not an essential element for plant growth, can be important for high Si-accumulating Poaceae, such as Moso bamboo. However, other trees do not actively take up dissolved silicic acid [Si(OH)4] from the soil, likely because they have fewer or no specific Si transporters in their roots. It is unclear what causes the different growth and nutrient status between bamboo and other trees under varying Si supply. To explore the influences of Si availability on the growth, photosynthesis, nutrient status and C:N:P stoichiometry of bamboo and other trees.MethodsWe used one-year seedlings of P. pubescens, P. bournei, S. superba and C. lanceolata in a pot experiment where three widely differing levels of silicon were supplied, and measured growth traits, photosynthetic gas exchange properties and C:N:P stoichiometry of seedling responses to three levels Si supply and analyzed the impacts of Si supply on growth and nutrient status of bamboo and tree saplings.ResultsWe found that Si increased the biomass production of P. pubescens seedlings with the higher concentration of Si supply, likely by improving its photosynthesis and nutrient status net photosynthetic rate, which contrasted to the seedlings of P. bournei and S. superba. In addition, we found that C concentrations of aboveground tissues in P. pubescens declined with increasing Si supply, likely due to a partial substitution of organic C compounds by Si. We also found that Si treatments increased the foliar C:N stoichiometry in the seedlings of P. bournei and S. superba through altering their concentration of C and N, but did not affect the C:N or N:P stoichiometry of C. lanceolata and P. pubescens.ConclusionsSi elicited either a positive or negative effect on plants, such as improve or weaken photosynthetic capacity, increase or decrease the concentration of C and N in plants, depending much on plant species and the ambient supply level of Si in the environment. These results have implications for assessing the growth and nutrient status between bamboo and other trees (i.e, high Si-accumulating plants compared to other plants) when Si availability is altered in ecosystems, such as when Si availability in ecosystems is altered by bamboo expansion.
Systematic Mapping of Monolithic Applications to Microservices Architecture
Authors: Seedat Momil , Abbas Qaisar , Ahmad Nadeem 
Published: August 2022

Abstract
In recent years, microservices architecture has emerged as a new architectural style in the software development industry. As legacy monolithic software becomes too large to manage, many large corporations are considering converting their traditional monolithic systems into small-scale, self-contained microservices. However, migrating from monolithic to microservices architecture is a difficult and challenging task. Finding clear instructions on refactoring monolithic applications can be difficult for software architects. In this paper, we compared the two architectural styles and talked about the difficulties that led to the companies' decision to switch over microservices architectures. Furthermore, a case study of a financial application is presented, in which we discussed our technique for identifying microservices on monolithic systems using domain driven concepts, as well as various communication protocols for service interaction. The study's findings showed that this proposed technique helped to establish clear models and enhanced work performance, but it may not be useful for systems with lower levels of complexity.
Warren Shunt- Positive Outcomes for Cavernous Portal Vein Transformation in a Young Patient
Authors: Adrian Boicean , Ciprian Tanasescu , Sabrina Birsan , Horatiu Dura , Cosmin Mohor , Calin Mohor , Dan Bratu , Radu Fleaca 
Published: August 2022

Abstract
In this paper we want to highlight the importance importance of Warren Shunt- (anastomosis of the splenic vein and the left renal vein) was performed in order to lower the PHT, and prevent the risk of gastrointestinal bleeding. Children with CTPV often manifest with gastroesphageal variceal bleeding which can be a life-threatening condition for young patients. Studies show that CTPV in cases of children may occur because of inherited or acquired prothrombotic disorders, abdominal infections. Our research team presents the case of a 22 years old, male patient, N. S. who had cavernous transformation of the portal vein at 2 years old and our case presentation presents the benefits of a surgical Warren Shunt- (anastomosis of the splenic vein and the left renal vein) in order to lower the PHT, and prevent the risk of gastrointestinal bleeding. In the case we present this type of surgical intervention was life saving and improved the quality of life of our patient.
Fourteen Traitors’ Portraits: on the Role of Visual Images in the English Cheap Print of the Late 16th Century
Authors: Карначук Н.В. 
Published: August 2022

В статье рассматривается комплекс бродсайдов, посвященных разоблачению заговора Энтони Бабингтона в 1586 г. Анализируется их авторство, текстовое и визуальное содержание, делается вывод о том, что они появились как пропагандистская попытка власти сформировать благоприятное общественное мнение. Особое внимание уделяется визуальным образам и особенностям их распространения, копирования и восприятия в массовом сознании англичан конца XVI века.
The article deals with a set of broadsides dedicated to exposing the conspiracy of Anthony Babington in 1586. Their authorship, textual and visual content is analyzed and it is concluded that they appeared as a propaganda attempt by the authorities to form a favorable public opinion. Particular attention is paid to visual images and the peculiarities of their distribution, copying and perception in the mass consciousness in late 16th century England.
“The Book of Tasty and Healthy Food” in the System of Ideological Myths Characteristic of the Transition from the Khrushchev Thaw to the Brezhnevian Stagnation
Authors: Попова О.Д. 
Published: August 2022

В статье анализируется место «Книги о вкусной и здоровой пище» 1960-х гг. в системе идеологической пропаганды. Автором показано, что текст книги отражал трансформации, которые происходили в повседневной жизни советских граждан под влиянием крушения «большого сталинского стиля». На основе выявленных обращений граждан в органы власти и к лидерам государства автор показывает трудности советского быта середины 1960-х: дефицит продуктов, проблемы получения качественного жилья и др. В итоге автор приходит к выводу о двойственности декларируемых в «Книге о вкусной и здоровой пище» принципов социалистического быта и реальных бытовых практик. Данное издание выполняло уже другую функцию, чем прежние: оно пыталось сгладить недостатки социалистического строя. Однако книга все больше превращалась в миф о благополучии советской системы, рассказывая о товарах, которые нельзя было найти на прилавках.
The article analyzes a fourth edition of the Book of Healthy and Tasty Food, which was published in the 1960s, against the backdrop of ideological propaganda characteristic of the period. The author maintains that the text of this edition reflected various transformations of Soviet citizens’ everyday life initiated by the Khrushchev thaw. The author analyzes Soviet citizens’ letters and appeals to government bodies and political leaders to highlight the difficulties experienced by Soviet citizens’ in their everyday life in the mid-1960s: food deficit, housing shortage, problems associated with female labour. The author concludes that there was a huge gap between the communist way of life advertised in the Book of Healthy and Tasty Food and the reality. The author underlines that the edition issued in the 1960s was hoped to mitigate the aforementioned problems. But it turned out to serve an image of what the Soviet state aspired to be, it became a myth of abundance which was hopelessly unattainable for a common Soviet person.
Political Authorities in Ancient India: Religious and Ideological Consideration and Forms of Implementation
Authors: Емельянова Н.Н. 
Published: August 2022

Статья посвящена социокультурным факторам обоснования и реализации политической власти в Древней Индии. Рассмотрены политические аспекты брахманизма: идея о политическом доминировании брахманов над кшатриями, идея о божественной природе царской власти, идея о насильственной природе власти. Отмечен новаторский характер этих идей для периода их возникновения и развития. Отдельное внимание уделено проблеме соотношения дхармы (следования долгу) и артхи (следования практической пользе) в гармоничном обществе. Рассмотрено решение этой проблемы политической мыслью Древней Индии, в том числе в политическом трактате «Артхашастра». Кроме того, в статье раскрыты монархические и республиканские традиции древнеиндийской государственности. Отмечается некорректность сведения традиции ранней индийской государственности исключительно к одной из модификаций восточного деспотизма.
The article is devoted to the socio-cultural factors of justification and implementation of political authority in Ancient India. The political aspects of Brahmanism are considered: the idea of the political dominance of Brahmins over Kshatriyas, the idea of the divine nature of royal authority, the idea of the violent nature of authority. The innovative nature of these ideas for the period of their origin and development is noted. Special attention is paid to the issue of the correlation of dharma (following duty) and artha (following practical benefits) in a harmonious society. The solution of this problem is considered by the political thought of Ancient India, including in the political treatise "Arthashastra". In addition, the article reveals the monarchical and republican traditions of Ancient Indian statehood. It is noted that it is not correct to reduce the tradition of early Indian statehood exclusively to one of the modifications of Eastern despotism.
Propaganda and Formation of Ideas about Civil Identity in the FBI (1930–1940’s)
Authors: Левин Я.А. 
Published: August 2022

Период 1930-х – 40-х гг. стал временем бурного развития такой структуры как Федеральное Бюро расследований. Пройдя через комплекс реформ Джона Эдгара Гувера, ведомство и его кадровый состав претерпели серьёзные изменения. Одним из важнейших вопросов, поднимаемых директором в ходе его преобразований, стал морально-нравственный облик агентов, правила поведения и идея гражданской идентичности в рядах ФБР. Выработанные в то время идеалы и модели поведения станут основной пропаганды этого ведомства на долгие годы.
The period of the 1930s - 40s became a time of rapid development of such a structure as the Federal Bureau of Investigation. Having gone through the reform complex of John Edgar Hoover, the department and its personnel have undergone serious changes. One of the most important issues raised by the director during his transformations was the moral appearance of agents, the rules of conduct and the idea of ​ ​ civic identity in the ranks of the FBI. The ideals and behaviors developed at that time will become the main propaganda of this department for many years.
Interview with Professor Malyn Newitt
Authors: Соколов А.Б. 
Published: August 2022

В интервью М. Ньюитт рассказал об обучении в Винчестере и в Оксфордском университете, о становлении своей профессиональной карьеры. Он делится воспоминаниями о преподавании в Родезии, рассказывает о формировании его исследовательских интересов в области истории Африки. В интервью затрагиваются не только направления научной работы историка, не только его общественная деятельность, но и черты развития профессии историка в целом, более, чем за полвека. М. Ньюитт изложил свои взгляды на основные тенденции в эволюции британской историографии, подчеркнул ее методологические особенности. Он обратил внимание на вклад отдельных ученых и достижения современной историографии.
In the interview the period of study of the future historian in Winchester and Oxford is considered, as well as formation of his professional carrier. Newitt shares his memoires about teaching in Rhodesia, tells us about the formation of his research interests in the field of history of Africa. In the interview not only his research and public activities are considered but the development of the profession of historian, in general, for longer than half a century. Professor Newitt explains his views on the main tendencies in evolution of British historiography, and stresses on its’ methodological particularities. He attracts attention to the contributions of some historians and the achievements of contemporary historiography.
Portrait in the manner of sfumato: Metaphor and intellectual biography
Authors: Селунская Н.А. 
Published: August 2022

Автор анализирует вышедшую в свет в 2021 г. книгу Т.Н. Поповой – исследование биографии оригинального мыслителя, историка, филолога, литературного критика П.М. Бицилли, а также те специфические историко-теоретические проблемы создания интеллектуальной биографии и изучения истории в персональном измерении, которые интерпретируются в монографии.
The author analyzes the recent monograph of T.N Popova, published in 2021 and devoted to biography of P. Bicilii, original thinker, historian. The book of Popova also deals with the problems of historiography, intellectual history, Russian emigration culture, personal history and intellectual biography.
Mythology of Time and Rhythms of Eternity: the Transformation of the Historical Culture of the Youth Movement in Germany (1900-1933)
Authors: Линченко А.А. 
Published: August 2022

Статья представляет собой рецензию на монографию Р.-Я. Адриаансена “The Rhythm of Eternity. The German Youth Movement and the Experience of the Past, 1900-1933”, где представлен анализ трансформации исторической культуры молодежного движения в Германии 1900–1933 гг., как в аспекте теоретических представлений о времени и истории, так и в аспекте коммеморативных практик молодежи. На основе идей Гумбрехта автор показывает, что активно формировавшаяся в начале ХХ в. историческая культура молодежного движения в Германии может быть рассмотрена как случай культуры присутствия, ориентированной на экзистенциальный опыт, космологические ритмы и пространственное восприятие событий прошлого. Вместе с тем эволюция оригинальной мифологии времени, выработанной в молодежной исторической культуре, была актуализирована политической и социально-экономической ситуацией, а молодежные движения, являясь частью «консервативной революции», стремились не столько противостоять модернистскому историческому сознанию, сколько трансформировать вектор его дальнейшего развития. На примере молодежного движения автор показывает, что историческая культура Веймарской Германии была своего рода «лабораторией экспериментов» с различными видами темпоральностей.
The article is a review of the monograph by R.-J. Adriaansen (R.-J. Adriaansen. The Rhythm of Eternity. The German Youth Movement and the Experience of the Past, 1900-1933. London / New York: Berghahn Books, 2015.227 p.). The monograph analyzes the features of the transformation of the historical culture of the youth movement in Germany in the period 1900-1933, both in the aspect of theoretical ideas about time and history, and in the aspect of commemorative practices of youth. Based on the ideas of H.U. Gumbrecht's, author shows that the historical culture of the youth movement in Germany, which was actively formed at the beginning of the last century, can be considered as a case of a presence culture focused on existential experience, cosmological rhythms and spatial perception of past events. At the same time, the book shows that the evolution of the original mythology of time, developed in the youth historical culture, was updated by the current political and socio-economic situation. The book substantiates the idea that the German youth movements of 1900-1933, being part of the “conservative revolution” of German society, did not so much strive to oppose the modernist historical consciousness as to transform the vector of its further development. Using the example of the German youth movement, the author shows that the historical culture of Weimar Germany was a kind of laboratory for experimenting with various types of temporalities.