bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-tissue metabolomic profiling reveals potential mechanisms of cocoon yield in silkworms (Bombyx mori) fed formula feed versus mulberry leaves
Authors: Wu Xuehui , Chen Xuedong , Ye Aihong , Cao Jinru , He Ruimin , Pan Meiliang , Jin Feng , Ma Huanyan , Zhou Wenlin 
Published: August 2022

Use of formula feed (FF) for silkworms for all instars, has promoted transformation and progress in traditional sericulture. However, the cocoon yield of FF silkworms has failed to reach that of silkworms fed mulberry leaves (ML). The biological mechanisms underlying this phenomenon have not been well described. This study aimed to identify metabolic mechanisms and potential biomarkers relating to the poor cocoon yield of FF silkworms. In this study, silkworms received treatments of either ML (ML group) or FF (FF group) for all instars. At the 3rd day of the 5th instar, the midgut (MG), hemolymph (HL) and posterior silk gland (PSG) were collected for the metabolome profiles detection. The remaining silkworms were fed ML or FF until cocooning for investigation. The whole cocoon yield (WCY) was significantly higher in the FF group than the ML group (p &lt; 0.05), whereas the cocoon shell weight (CSW) and cocoon shell rate (CSR) were significantly lower in the FF group (p &lt; 0.05). A total of 845, 867 and 831 metabolites were qualified and quantified in the MG, HL and PSG of the FF silkworms, respectively. Correspondingly, 789, 833 and 730 metabolites were quantified in above three tissues of the ML group. Further, 230, 249 and 304 significantly different metabolites (SDMs) were identified in the MG, HL and PSG between the FF and ML group, respectively. Eleven metabolic pathways enriched by the SDMs were mutual among the three tissues. Among them, cysteine and methionine metabolism, arginine biosynthesis, and arginine and proline metabolism were the top three pathways with the highest impact value in the PSG. Six biomarkers were obtained through biomarker analysis and Pearson correlation calculation. Among them, homocitrulline, glycitein, valyl-threonine, propyl gallate and 3-amino-2,3-dihydrobenzoic acid were positively correlated with WCY, but negatively correlated with CSW and CSR (p &lt; 0.05). An opposite correlation pattern was observed between 3-dimethylallyl-4-hydroxyphenylpyruvate and the three cocoon performance traits. Overall, three key metabolic pathways and six biomarkers associated with cocoon yield were interpreted, and should provide directions for formula feed optimization in factory-raised silkworms.
The association between blood MxA mRNA and long-term disease activity in early multiple sclerosis
Authors: Coerver Eline M. E. , Strijbis Eva M. M. , Petzold Laura F. , Van Kempen Zoé L. E. , Jasperse Bas , Barkhof Frederik , Oudejans Cees B. M. , Uitdehaag Bernard M. J. , Teunissen Charlotte E. , Killestein Joep 
Published: August 2022

BackgroundMyxovirus resistance protein A (MxA) is a protein that is upregulated by interferon-beta. Homeostatic MxA mRNA levels are potentially correlated with inflammatory disease activity in multiple sclerosis (MS) and could have an important role in MS pathology.AimTo investigate the association between myxovirus resistance protein A (MxA) mRNA levels in blood and disease activity and progression in MS over a long-term follow-up period.MethodsBaseline blood MxA mRNA levels were determined in a prospective cohort of 116 untreated patients with a clinically isolated syndrome (CIS) or early relapsing remitting MS (RRMS), and related to long-term relapses, radiological disease activity, clinical scores [Expanded Disability Status Scale (EDSS), timed-25-foot walk (T25FW), 9-hole-peg test (9HPT)], MS type, and disease modifying therapy (DMT) use.ResultsLow MxA mRNA levels were associated with the occurrence of ≥9 T2-lesions on MRI imaging and the occurrence of relapses during long-term follow-up (median 11 years, IQR 5.91–13.69 years). MxA mRNA levels were not associated with EDSS, T25FW, 9HPT, and MS subtype.ConclusionBaseline MxA mRNA levels are associated with long-term development of T2-lesions on MRI-scans in our cohort. This confirms the relevance of the endogenous interferon-beta system in the occurrence of MS disease activity.
Incidence of bifid pancreatic duct in pancreaticoduodenectomy and its impact on clinically relevant postoperative pancreatic fistula
Authors: Ouyang Liu , Hu Hao , Nie Gang , Yang Li-xue , Huang Zhi-ping , Ni Chen-ming , Shao Zhuo , Zheng Kai-lian , Jing Wei , Song Bin , Li Gang , Hu Xian-gui , Jin Gang 
Published: August 2022

ObjectivesThis study aimed to examine the incidence of bifid pancreatic duct (BPD) in pancreaticoduodenectomy (PD) and clarify its impact on clinically relevant postoperative pancreatic fistula (CR-POPF).BackgroundUntil now, all the literature about BPD during PD are published as case reports, and the incidence of BPD in PD and its impact on CR-POPF remain unknown.ResultsA total of 438 consecutive PDs were divided into two groups: the former year group and the latter year group. The former year group included 215 consecutive PDs, while the latter year group included 223. In the latter year group, we found 16 BPDs during PD (O-BPD); the incidence of O-BPD is 7.17%. Of them, there were eight patients who had BPD in the preoperative imaging (I-BPD). All the I-BPDs are O-BPDs; which means that 50% of O-BPDs were a single pancreatic duct in the preoperative imaging (I-SPD). There were 17 I-BPDs in the 438 consecutive PDs; the incidence of I-BPD is 3.88%. In the former year group, the rate of severe complications of I-BPD and I-SPD is 77.78% and 27.18%, respectively (p = 0.003); the rate of CR-POPF of I-BPD is higher than I-SPD, 55.56% vs. 27.18%, but there were no statistically significant differences. In the latter year group, the rate of severe complications of O-BPD and O-SPD is 50% and 18.36%, and the rate of CR-POPF of O-BPD and O-SPD is 37.5% and 22.22%, respectively; both of them have statistically significant differences, and the p-value is 0.003 and 0.006, respectively. In the subgroup analysis, both the rate of severe complications and the rate of CR-POPF of I-BPD were higher than O-BPD, 77.78% vs. 50%, and 55.56% vs. 37.5%, but there were no statistically significant differences in both of them; the p-value is 0.174 and 0.434, respectively. Univariate and multivariate analyses showed that BPD was an independent risk factor of CR-POPF.ConclusionsThe incidence of O-BPD in PD is 7.17%, 50% of O-BPDs were I-SPD, and the incidence of I-BPD is 3.88%. BPD is an independent risk factor of CR-POPF. The suture closure method may be a simple, safe, and effective method in dealing with BPD in PD.
Comparison of clinical outcomes between cone beam CT-guided thermal ablation and helical tomotherapy in pulmonary metastases from hepatocellular carcinoma
Authors: Wang Feihang , Fan Shaonan , Shi Qin , Zhao Danyang , Sun Huiyi , Sothea Yav , Wu Mengfei , Song Huadan , Chen Yi , Cheng Jiemin , Zeng Zhaochong , Yan Zhiping , He Jian , Liu Lingxiao 
Published: August 2022

ObjectiveThis retrospective study compares the clinical results of cone beam CT (CBCT)-guided thermal ablation with those of helical tomotherapy in hepatocellular carcinoma (HCC) patients with pulmonary metastases.MethodsA total of 110 patients undergoing thermal ablation or helical tomotherapy for pulmonary metastases from April 2014 to December 2020 were included in the study. The endpoints were local tumor progression-free survival (LTPFS), overall survival (OS), and complications. Univariate and multivariate analyses using the Cox proportional hazard model were conducted to identify independent factors (univariate: P &lt; 0.1; multivariate: P &lt; 0.05). The Kaplan–Meier method was used to calculate the LTPFS and OS rates.ResultsThe results of 106 patients were taken into the final analysis. The 1- and 3-year LTPFS rates were 50 and 19% for the thermal ablation group and 65 and 25% for the helical tomotherapy group. The median LTPFS in the thermal ablation group was 12.1 months, while it was 18.8 months in the helical tomotherapy group (P = 0.25). The 1- and 3-year OS rates were 75 and 26% for the thermal ablation group and 77 and 37% for the helical tomotherapy group. The median OS was 18.0 months in the thermal ablation group and 23.4 months in the helical tomotherapy group (P = 0.38). The multivariate analyses found that α-fetoprotein (AFP) at &lt;400 ng/ml (P = 0.003) was significantly associated with better LTPFS. Tumor number &lt;3 and AFP &lt;400 ng/ml were favorable prognostic factors for OS. There were no grades 3–5 adverse events in both groups. Grade 2 was recorded in three patients (4.8%) in the thermal ablation group and two patients (4.7%) in the helical tomotherapy group.ConclusionsFor pulmonary metastases from HCC, CBCT-guided thermal ablation and helical tomotherapy provided comparable clinical effects and safety.
Making Change: Attempts to Reduce or Stop Gambling in a General Population Sample of People Who Gamble
Authors: Hodgins David C. , Williams Robert J. , Belanger Yale D. , Christensen Darren R. , El-Guebaly Nady , McGrath Daniel S. , Nicoll Fiona , Shaw Carrie A. , Stevens Rhys M. G. 
Published: August 2022

ObjectiveThis study examined past year attempts to reduce or quit gambling among people who gamble generally and those with gambling problems specifically.MethodsRegular gamblers recruited from an online panel (N = 10,054) completed a survey of gambling, mental health and substance use comorbidity and attempts to reduce or quit gambling. The sample was weighted to match the gambling and demographic profile for the same subsample (i.e., past month gamblers) in a recent Canadian national survey.Results5.7% reported that they tried to cutback or stop gambling in the past year. As predicted, individuals making a change attempt had greater levels of problem gambling severity and were more likely to have a gambling problem. Of individuals with problem gambling, 59.8% made a change attempt. Of those, 90.2% indicated that they did this primarily on their own, and 7.7% accessed formal or informal treatment. Most people attempting self- change indicated that this was a personal preference (55%) but about a third reported feeling too ashamed to seek help. Over a third (31%) reported that their attempt was successful. Of the small group of people accessing treatment, 39% described it as helpful.ConclusionsWhereas gambling treatment-seeking rates are low, rates of self-change attempts are high. The public health challenge is to promote self-change efforts among people beginning to experience gambling problems, facilitate success at self-change by providing accessible support for use of successful strategies, and provide seamless bridges to a range of other treatments when desired or required.
Resilience and mental health: A longitudinal cohort study of Chinese adolescents before and during COVID-19
Authors: Shi Wei , Zhao Li , Liu Min , Hong Binxue , Jiang Lihua , Jia Peng 
Published: August 2022

BackgroundThe COVID-19 outbreak has resulted in mental health issues, mainly depression and anxiety, prompted by stressors such as the need to maintain social distance, adapting to quarantine, and lockdown policies. Resilience may be vital in protecting individuals from mental disorders. However, few studies have examined the longitudinal relationships between resilience and mental disorders (i.e., depression and anxiety) among adolescents before and during the COVID-19 pandemic.ObjectiveThis study aimed to examine the association between resilience, depression, and anxiety among Chinese adolescents before and during COVID-19 using a longitudinal cross-lagged model.MethodsA total of 7,958 Chinese adolescents completed a baseline survey in the month before COVID-19 and were followed up after the COVID-19 lockdown. Structural equation modeling analyses were applied to evaluate the associations between resilience, depression, and anxiety after controlling for three covariates (i.e., gender, age, and COVID-19 effect).ResultsA higher level of resilience before COVID-19 significantly predicted decreased severity of depression and anxiety after the lockdown. Moreover, the mean level of resilience and prevalence of mental disorders (i.e., depression and anxiety) among Chinese adolescents decreased after the lockdown. These findings suggest resilience is a vital protective factor against depression and anxiety among adolescents. Furthermore, younger participants and those less affected by the pandemic could be more resilient. No significant link was found between gender and resilience in the second wave.ConclusionsResilience is an essential protective factor for reducing mental disorders among Chinese adolescents exposed to COVID-19. Resilience-related interventions should be developed to efficiently promote mental health recovery among youth during pandemics.
Phenolic Acids from Fructus Chebulae Immaturus Alleviate Intestinal Ischemia-Reperfusion Injury in Mice through the PPARα/NF-κB Pathway
Authors: Liu Junjie , Li Bin , Liu Jing , Qiu Feng , Diao Yunpeng , Lei Yuxin , Liu Jianjun , Zhang Wei 
Published: August 2022

Intestinal ischemia/reperfusion (II/R) injury is a common life-threatening complication with high morbidity and mortality. Chebulae Fructus Immaturus, the unripe fruit of Terminalia chebula Retz., also known as “Xiqingguo” or “Tibet Olive” in China, has been widely used in traditional Tibetan medicine throughout history. The phenolic acids’ extract of Chebulae Fructus Immaturus (XQG for short) has exhibited strong antioxidative, anti-inflammation, anti-apoptosis, and antibacterial activities. However, whether XQG can effectively ameliorate II/R injuries remains to be clarified. Our results showed that XQG could effectively alleviate II/R-induced intestinal morphological damage and intestinal barrier injury by decreasing the oxidative stress, inflammatory response, and cell death. Transcriptomic analysis further revealed that the main action mechanism of XQG protecting against II/R injury was involved in activating PPARα and inhibiting the NF-κB-signaling pathway. Our study suggests the potential usage of XQG as a new candidate to alleviate II/R injury.
Systematic Review: The Effect of Covid-19 on Anxiety in Pregnant Women
Authors: Anita Dewi Anggraini  , Budi Prasetyo  , Rachmah Indawati  
Published: August 2022

Pregnancy is a very vulnerable period in a woman's life. Hormonal changes during pregnancy can affect emotional instabilityThe anxiety caused will have an impact on the health of mothers and children such as the risk of preeclampsia, premature birth, low birth weight, and fetal growth restriction. This study aims to determine the existing literature on the impact of COVID-19 on anxiety in pregnant women. This study used a systematic literature review method. The population in this study were journals from the Pubmed, Science Direct, Sage, Emerald, and Proquest databases published between 2020 and 2021. Result of study was a total of 15 of the 675 articles met the inclusion criteria. This study found that 8 out of 15 articles experienced an increase in the prevalence of anxiety in pregnant women by more than half a percent (90.5%; 57.8%; 77%; 64.5%) and experienced an increase in anxiety prevalence by more than a quarter percent ( 43.9%; 46.3%; 25.6%; 37.5%. In addition, this study found differences in the anxiety of pregnant women between before COVID-19 and during COVID-19 Pandemics. Anxiety in pregnant women included gestational age, demographics, socioeconomic status, knowledge, social support, and physical activity. The COVID-19 pandemic could increase anxiety in pregnant women. Mental health of pregnant women should be one of the priorities in public health to improve the welfare of pregnant women. Policymakers and health planners need to consider mental health in pregnant women in designing procedures to deal with the COVID-19 pandemic.
Is prediction of local recurrence possible in Paget’s disease of the breast?
Authors: Turanli Sevim 
Published: August 2022

Objective: Mammary Paget disease of the breast is a rare form of breast cancer. The study aimed to predict the patients prone to local recurrence, and to find out the answer to the question of who should be a candidate for breast conserving surgery.
Material and Methods: Between January 2007 and February 2022, 83 patients who underwent surgery and pathology report diagnosed as Paget’s disease, were analyzed retrospectively. As factors that may affect local recurrence; age, presence of nipple symptoms, mass detection in radiological imaging, type of the surgery, stage, pathological findings of the tumor (histological type, multicentricity, ER, PR, HER2, Ki 67 proliferative index, molecular subtype) were evaluated.
Results: Among 83 patients, 32 (38.6%) had ductal carcinoma in situ, and 50 patients (60.2%) had invasive ductal carcinoma, and others had pure Paget disease. Number of the patients who underwent breast-conserving surgery and mastectomy was 19 and 64, respectively. Patients were followed-up for a median time of 73 months. Recurrence was developed in 12 patients (14.5%), 7 of them with local recurrence. Type of the surgery (p=0.001) and young age (p=0.02) were the factor influencing local recurrence. Subgroup analysis was performed among patients undergoing breast-conserving surgery, and age (p=0.07) and absence of nipple symptoms (p=0.07) were found to affect local recurrence.
Conclusion: Although the number of patients is small, it should be kept in mind that local recurrence may be high when breast-conserving surgery is performed in patients with young age
Strategi Mengajar Guru Dalam Meningkatkan Minat Belajar Bahasa Arab Peserta Didik Pada Masa Pandemi Covid-19 (Teacher Teaching Strategies in Increasing Students' Interest in Arabic Learning During the Covid-19 Pandemic)
Authors: Baharuddin Baharuddin , Mahmud Basri , Hasmawati Hasmawati , Munawarah Munawarah , Zulkiflih Zulkiflih 
Published: August 2022

Penelitian ini bertujuan untuk mengetahui langkah-langkah guru bahasa Arab dalam meningkatkan minat belajar bahasa Arab peserta didik kelas VIII MTs DDI Kanang Polewali Mandar selama Pandemi Covid 19. Penelitian ini termasuk dalam penelitian lapangan jenis penelitian deskriptif kualitatif yang ditinjau dari tempat penelitian. Dalam hal data, ini adalah penelitian deskriptif. Instrumen dalam penelitian ini adalah peneliti sendiri yang dibantu pedoman observasi, wawancara dan dokumentasi. Teknik analisis data yaitu diawali dengan reduksi data, penyajian data, kemudian verifikasi dan penarikan kesimpulan. Pengujian keabsahan data dengan cara menggunakan triangulasi. Hasil penelitian ini yaitu 1) langkah-langkah yang dilakukan guru dalam meningkatkan minat belajar bahasa Arab peserta didik kelas VIII MTs DDI Kanang Polewali Mandar pada Masa Pandemi Covid-19 adalah dilakukan dengan dua sistem, yaitu sistem secara daring dan luring, adapun daring menggunakan metode ceramah dan metode tanya jawab, sedangkan luring menggunakan metode campuran. 2) Kendala yang dihadapi oleh guru dalam meningkatkan minat belajar peserta didik adalah jaringan internet yang tidak stabil, durasi waktu pembelajaran yang terbatas, dan kurangnya minat peserta didik dalam pembelajaran bahasa Arab. This study aims to find out the steps of Arabic teacher in increasing interest in learning Arabic students of class VIII MTs DDI Kanang Polewali Mandar Regency during the Covid 19 Pandemic. This research is included in the field research type of qualitative descriptive research that is reviewed from the research site. In terms of data, this is descriptive research. The instruments in this study are the researchers themselves who assisted in observation guidelines, interviews and documentation. Data analysis techniques are initiated by data reduction, data presentation, and then data verification and conclusion. Testing the validity of data by using triangulation. The results of this study are 1) the steps taken by teachers in increasing the interest in learning Arabic students of class VIII MTs DDI Kanang Binuang Polewali Mandar Regency during the Covid-19 Pandemic are carried out with two systems, namely online system and offline system, while online using lecture methods and question and answer methods, while offline using mixed methods. 2) The obstacles faced by teachers in increasing the interest in learning learners are unstable networks, limited time, lack of interest in students in learning Arabic.
Huruf Jar Ba dan Kandungan Maknanya dalam Q.S. Al-Maidah (The Letter Jar Ba and Its Meaning in Q.S. Al-Maidah)
Authors: Asdaliah Nur , Mukhtar Mukhtar , Hamzah Hamzah , Mahmud Basri , Mujahid Mujahid 
Published: August 2022

Penelitian ini bertujuan untuk mengetahui dan memahami makna huruf jar Ba yang terdapat dalam al-Quran khususnya pada surah Al-Maidah. Penelitian ini termasuk kajian kepustakaan (library research) yaitu teknik pengumpulan datanya melalui studi telaah terhadap isi buku-buku, literatur, catatan atau artikel ilmiah yang ada Adapun hasil penelitian ini, terdapat huruf jar ba sebanyak 91 kali terulang dalam surah Al-Maidah, dengan 5 makna huruf jar yang dapat diklasifikasikan sebagai berikut: 1) Bermakna al-Isti’anah terdapat pada ayat ke 3 dan 45. 2) Bermakna al-Mushahabah terdapat pada ayat ke 8, 13, 16, 29 dan 36. 3) Bermakna sababiyah terdapat pada ayat ke 13, 18, 32, 44 dan 58. 4) Bermakna al-Qasam terdapat pada ayat ke 53, 106 dan 107. Dan 5) Bermakna al-Tab’idiyyah dan atau al-Ilshaq pada ayat ke 6. This research aims to find out and understand the meaning of the letter jar ba contained in the Quran, especially in the Surah Al-Maidah. This research is a library research, namely a data collection technique through a study of the contents of existing books, literature, notes or scientific articles. The results of this study, there is a jar letter ba as many as 91 times repeated in the surah Al-Maidah, with 5 meanings of the letter jar which can be classified as follows: 1) al-isti'anah is found in verses 3 and 45. 2) al-mushahabah is found in verses 8, 13, 16, 29 and 36. 3) sababiyah is found in verses 13, 18, 32, 44 and 58. 4) al-qasam is found in verses 53, 106 and 107. And 5) the meaning of al-tab'idiyyah and or al-ilshaq is found in verse 6.
PERBANDINGAN PENANGANAN HUTANG PIUTANG DI BANK BNI SYARIAH DAN BAITUL MAAL WAT TAMWIL FAJAR
Authors: Kusnandar Enan , Midisen Kisanda , Rahmadani Sekar Ayu 
Published: August 2022

To deal with problems related to sources of funds or capital is the bank. Currently, people are more interested in Islamic institutions. Both Islamic banks and BMTs are shariah. In this study the authors found two institutions that have differences in the handling of accounts payable. Therefore, the author is interested in finding out more about the differences between the two institutions. The purpose of this study is to find out the differences in how to handle accounts payable. To find out the difference in the way of handling accounts payable to customers who died and customers who were affected by the disaster, To find out how the Islamic perspective in handling accounts payable.
Al-Qardh is property that is cut to help people in need and then returned to the debtor in full as he received it. In this study there are differences in the handling of accounts payable.
This research includes descriptive qualitative research that focuses intensively on a particular object to study it as a case and reveals events or facts, circumstances, phenomena, variables and circumstances that occurred during the research by writing down what actually happened.
The results of this study are the findings of 2 differences between BNI Syariah Banks that use insurance in each of their financing as a protection system to benefit both parties. And KSPPS BMT Fajar does not use insurance in every financing because the BMT thinks that insurance is the same as gambling, the system is gharar. However, from the two institutions, the implementation is in accordance with sharia principles.
Based on the research, it can be concluded that there are differences in the handling of accounts payable in the protection system at BNI Syariah Bank while BMT Fajar does not use a protection system. However, both institutions are in accordance with Islamic law.