bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of idiopathic versus secondary nodular regenerative hyperplasia of the liver: A longitudinal study of 167 cases
Authors: Penrice Daniel D. , Thakral Nimish , Kezer Camille A. , Lennon Ryan , Moreira Roger K. , Graham Rondell P. , Kamath Patrick S. , Simonetto Douglas A. 
Published: February 2022

AbstractBackgroundNodular regenerative hyperplasia (NRH) is a rare condition characterized clinically by the development of non‐cirrhotic portal hypertension. NRH is the histopathological result in the liver of various systemic disease processes including autoimmune disorders, haematological malignancies and medications. However, natural history of this condition has been limited to small case series while patient outcomes pertaining to different aetiologies of NRH are largely unknown.MethodsA retrospective cohort of consecutive patients diagnosed with pathology‐confirmed NRH at Mayo Clinic between 2002 and 2017 was identified. The histological diagnosis of NRH was determined by expert liver pathologists. Patients with metastatic liver disease, history of liver transplantation or younger than 18 were excluded. Potential aetiologies of NRH were classified as haematological, rheumatological, drug‐associated, miscellaneous or idiopathic. Long‐term mortality was analysed using Kaplan‐Meier estimation and Cox regression models.ResultsOne hundred and sixty‐seven consecutive patients with pathology‐confirmed NRH were analysed over a 15‐year period and followed for a median time of 50 months (1–306 months). The mean age at diagnosis was 53 years. No aetiology or risk factor for NRH was identified in the majority of patients (94, 56.3%), whereas an associated, possibly causal, condition was found in 73 patients (secondary NRH). The most common presenting feature was elevated liver tests (80%), but no significant differences in laboratory tests were seen based on aetiology of NRH. Compared to idiopathic NRH, those with an identified cause had a higher rate of splenomegaly at presentation (54% vs. 27%, p = 0.002). Portal hypertension‐related complications at diagnosis were common, with ascites present in one‐third of patients. Overall transplant‐free survival was 63% at 5 years. Median survival in idiopathic NRH was 9.4 years compared to 7.3 years in secondary NRH. Age, renal function and volume status at presentation were significantly associated with survival; however, MELD score was not.ConclusionsThe rates of liver‐related complications and mortality in NRH are low, and only a small number of patients ultimately require liver transplantation. Most patients do not have an identified risk factor or aetiology for NRH, and liver‐related outcomes do not appear to differ based on associated, possibly causal, conditions.
Economic policy uncertainty and unconventional monetary policy
Authors: Funashima Yoshito 
Published: February 2022

AbstractIn this study, the US daily economic policy uncertainty (EPU) index is employed to examine how EPU changes because of the implementation of and exit from the unconventional monetary policy adopted by the Federal Open Market Committee (FOMC). The analysis suggests that forward guidance lowers the volatility of EPU. Moreover, the EPU level decreases during the tapering period of quantitative easing. This may be attributable to the unequivocal expected lifting of the zero interest rate policy. In contrast to these findings favoring the FOMC’s successful communication, it is found that time‐contingent forward guidance increases EPU.
Partnering to Learn: A Collaborative Approach to Research Translation for Educators and Researchers
Authors: MacMahon Stephanie , Leggett Jack , Carroll Annemaree 
Published: February 2022

ABSTRACTThe science of learning (SoL) has powerful contributions to make to both the production of knowledge about learning and to the ways in which this knowledge can be successfully mobilized into educational practice. However, as a multidisciplinary field, it also faces some challenges if it is to bridge the research‐practice gap. Using Levin's (2013) conceptualization of knowledge mobilization, this paper will describe the challenges and promising approaches to effective research translation and frame existing approaches across three interacting domains of (1) knowledge production, (2) knowledge use, and (3) knowledge mediation. It will then present a novel partnership approach developed by the Science of Learning Research Center at The University of Queensland, Australia—the Partner Schools Program (PSP). Drawing upon existing promising practices, the PSP brings together educators, researchers, and research brokers in partnership to transform research into contextually relevant applications.
Novelty processing associated with neural beta oscillations improves recognition memory in young and older adults
Authors: Steiger Tineke K. , Sobczak Alexandra , Reineke Ramona , Bunzeck Nico 
Published: February 2022

AbstractNovelty anticipation activates the mesolimbic system and promotes subsequent long‐term memory in younger adults. Importantly, mesolimbic structures typically degenerate with age, which might reduce positive effects of novelty anticipation. Here, we used electroencephalography in combination with an established paradigm in healthy young (19–33 years old, n = 28) and older (53–84, n = 27) humans. Colored cues predicted the subsequent presentation of either a novel or previously familiarized image (75% cue validity). On the subsequent day, recognition memory for the novel images was tested. Behaviorally, novelty anticipation improved recollection‐based but not familiarity‐based recognition memory in both groups, and this effect was more pronounced in older subjects. Furthermore, novelty and familiarity cues increased theta (4–8 Hz) and decreased alpha/beta power (9–20 Hz); at outcome, expected novel and familiar images both increased beta power (13–25 Hz). Finally, a subsequent memory effect for expected novel images was associated with increases in beta power independent of age. Together, novelty anticipation drives hippocampus‐dependent long‐term recognition memory across the life span, and this effect appears to be related to neural beta oscillations.
Lower caprylate and acetate levels in the breast milk is associated with atopic dermatitis in infancy
Authors: Wang Li‐Chieh , Huang Yen‐Ming , Lu Chieh , Chiang Bor‐Luen , Shen Ying‐Rou , Huang Hsun‐Yi , Lee Chien‐Chang , Su Nan‐Wei , Lin Bi‐Fong 
Published: February 2022

AbstractBackgroundAtopic dermatitis (AD) occurs in exclusively breastfed infants. As fatty acids have some immunomodulatory effect, we aimed to investigate the influence of fatty acid compositions in breast milk (BM) on the development of AD in exclusively breastfed infants.MethodsWe enrolled two‐ to four‐month‐old exclusively breastfed infants. The objective SCORing Atopic Dermatitis (objSCORAD) was evaluated. The lipid layer of BM was analyzed by gas chromatography for fatty acid levels. Medical charts were reviewed.ResultsForty‐seven AD infants and 47 healthy controls were enrolled. The objSCORAD was 20.5 ± 1.7 (shown as mean ± SEM) in the AD group. The age, sex, parental atopy history, and nutrient intake of mothers were not significantly different between two groups. The palmitate and monounsaturated fatty acid (MUFA) levels in BM positively correlated with objSCORAD, while caprylate, acetate, and short‐chain fatty acid (SCFA) levels negatively correlated with objSCORAD (p = .031, .019, .039, .013, .022, respectively). However, the butyrate levels in BM were not significantly different. The caprylate and acetate levels in BM were significantly associated with the presence of infantile AD (p = .021 and .015, respectively) after adjusting for age, sex, parental allergy history, MUFA, palmitate, and SCFA levels in BM. ObjSCORAD in infancy was significantly associated with persistent AD (p = .026) after adjusting for age, sex, parental atopy history, caprylate, palmitate, MUFA, acetate, and SCFA levels in BM.ConclusionCaprylate and acetate levels in BM for exclusively breastfed infants were negatively associated with objSCORAD. Lower caprylate and acetate in BM might be the risk factors for infantile AD, while butyrate in BM was not associated with infantile AD.
OsCOMT, encoding a caffeic acid O‐methyltransferase in melatonin biosynthesis, increases rice grain yield through dual regulation of leaf senescence and vascular development
Authors: Huangfu Liexiang , Chen Rujia , Lu Yue , Zhang Enying , Miao Jun , Zuo Zhihao , Zhao Yu , Zhu Minyan , Zhang Zihui , Li Pengcheng , Xu Yang , Yao Youli , Liang Guohua , Xu Chenwu , Zhou Yong , Yang Zefeng 
Published: February 2022

SummaryMelatonin, a natural phytohormone in plants, plays multiple critical roles in plant growth and stress responses. Although melatonin biosynthesis‐related genes have been suggested to possess diverse biological functions, their roles and functional mechanisms in regulating rice grain yield remain largely unexplored. Here, we uncovered the roles of a caffeic acid O‐methyltransferase (OsCOMT) gene in mediating rice grain yield through dual regulation of leaf senescence and vascular development. In vitro and in vivo evidence revealed that OsCOMT is involved in melatonin biosynthesis. Transgenic assays suggested that OsCOMT significantly delays leaf senescence at the grain filling stage by inhibiting degradation of chlorophyll and chloroplast, which, in turn, improves photosynthesis efficiency. In addition, the number and size of vascular bundles in the culms and leaves were significantly increased in the OsCOMT‐overexpressing plants, while decreased in the knockout plants, suggesting that OsCOMT plays a positive role in vascular development of rice. Further evidence indicated that OsCOMT‐mediated vascular development might owe to the crosstalk between melatonin and cytokinin. More importantly, we found that OsCOMT is a positive regulator of grain yield, and overexpression of OsCOMT increase grain yield per plant even in a high‐yield variety background, suggesting that OsCOMT can be used as an important target for enhancing rice yield. Our findings shed novel insights into melatonin‐mediated leaf senescence and vascular development and provide a possible strategy for genetic improvement of rice grain yield.
Changes in genotoxic stress response, ribogenesis and PAP (3′‐phosphoadenosine 5′‐phosphate) levels are associated with loss of desiccation tolerance in overprimed Medicago truncatula seeds
Authors: Pagano Andrea , Zannino Lorena , Pagano Paola , Doria Enrico , Dondi Daniele , Macovei Anca , Biggiogera Marco , Araújo Susana de Sousa , Balestrazzi Alma 
Published: February 2022

AbstractRe‐establishment of desiccation tolerance is essential for the survival of germinated seeds facing water deficit in the soil. The molecular and ultrastructural features of desiccation tolerance maintenance and loss within the nuclear compartment are not fully resolved. In the present study, the impact of desiccation‐induced genotoxic stress on nucleolar ultrastructure and ribogenesis was explored along the rehydration−dehydration cycle applied in standard seed vigorization protocols. Primed and overprimed Medicago truncatula seeds, obtained through hydropriming followed by desiccation (dry‐back), were analysed. In contrast to desiccation‐tolerant primed seeds, overprimed seeds enter irreversible germination and do not survive dry‐back. Reactive oxygen species, DNA damage and expression profiles of antioxidant/DNA Damage Response genes were measured, as main hallmarks of the seed response to desiccation stress. Nuclear ultrastructural features were also investigated. Overprimed seeds subjected to dry‐back revealed altered rRNA accumulation profiles and up‐regulation of genes involved in ribogenesis control. The signal molecule PAP (3′‐phosphoadenosine 5′‐phosphate) accumulated during dry‐back only in primed seeds, as a distinctive feature of desiccation tolerance. The presented results show the molecular and ultrastructural landscapes of the seed desiccation response, including substantial changes in nuclear organization.
Do clinical severity scores correlate with the quality of life in children with psoriasis? A cross‐sectional study of Iranian pediatric patients
Authors: Nourmohammadpour Pedram , Ehsani Amir Hooshang , Hatami Parvaneh , Fakoor Yousef , Fahim Shabnam , Mohsenolhosseini Zahra , Aryanian Zeinab 
Published: February 2022

AbstractBackgroundPsoriasis is a common chronic dermatosis that can negatively affect patients' lives.AimTo obtain more insight about how having psoriasis and how the various clinical and physical characteristics of the disease impact the health‐related quality of life (HRQoL) of pediatric patients.MethodsA retrospective cross‐sectional study was designed with 40 pediatric patients with psoriasis. HRQoL was evaluated using the Children Dermatology Life Quality Index (CDLQI).ResultsA total of 40 patients enrolled in this study. The mean age of participants was 12.42 ± 7.1 years (age range: 4–16 years), 21 males (52.5%), and 19 females (47.5%). The mean Psoriasis Area Severity Index (PASI) score was 8.03 ± 9.31 with a range of 0.4–25.Mean CDLQI score was 18.87 ± 8.15, indicating a considerable burden on health‐related QoL. There was a strong positive correlation between CDLQI and PASI scores (p < .001, r: .653).ConclusionThe negative effect of psoriasis on HRQoL in pediatrics was confirmed, and a strong correlation between disease severity scores and HRQoL in children with psoriasis was found in this study. Taking HRQoL indices into account while managing adolescent patients will improve our insight into the patient's experience and may provide better patient adherence to treatment.
Concurrent allergy and helminthiasis in underprivileged urban South African adults previously residing in rural areas
Authors: Mkhize‐Kwitshana Zilungile Lynette , Naidoo Pragalathan , Nkwanyana Ntombifikile M. , Mabaso Musawenkosi L. H. 
Published: February 2022

AbstractThis study investigated whether prior exposure to helminths (Ascaris IgE, Ascaris eggs and Trichuris eggs) either in childhood or in adulthood, and residence in rural and resource‐limited urban areas influence allergy outcomes (asthma, rhinitis, IgE atopy and food allergy) in a South African population. Participants historical and present allergies data were collected through questionnaires and clinical record files. Coproscopy and immunoassays (ImmunoCAPTM Phadiatop, total IgE and allergen‐specific fx3 IgE immunoassays and Ascaris IgE radioallergosorbent [RAST] tests) were used for active helminthiasis and allergy screens respectively. Data were analysed using logistic regression analysis, and models were adjusted for age, gender and locality. High Ascaris IgE was significantly associated with asthma (adjusted odds ratio [aOR] = 2.20, p = .047), IgE atopy (aOR = 18.18, p < .0001) and food allergy (aOR = 14.47, p < .0001). Asthma was significantly less likely among participants with Ascaris eggs (aOR = 0.43, p = .048) and Trichuris eggs (aOR = 0.36, p = .024). The findings of co‐occurrent helminthiasis and allergic disorders in a population that has resided both in rural and peri‐urban informal settlements both oppose and agree with two main notions of the hygiene hypothesis that (i) individuals residing in rural settings with poor sanitation and geohelminth infection are less prone to allergy, and (ii) helminth infections protect against allergy respectively. Further research is warranted.
Thirty years of rice‐crab coculture in China—Research progress and prospects
Authors: Bao Jie , Jiang Hongbo , Li Xiaodong 
Published: February 2022

AbstractChinese mitten crab (Eriocheir sinensis) culture in rice paddy fields is a representative model of integrated agriculture‐aquaculture systems developed in China over the last 30 years. The economic and ecological benefits of rice‐crab coculture are significantly improved compared to those of rice monoculture. Under coculture conditions, rice provides shelter for crabs and improves the aquatic environment, while crabs eliminate pests and weeds, reduce the need for chemical fertilizers and pesticides, and stabilize rice production. At the same time, rice‐crab coculture helps protect biodiversity and reduce greenhouse gas emissions. An in‐depth study has led to the significant development of rice‐crab coculture technology in China and has established ecological breeding models with regional characteristics. These studies have established breeding industry standards for paddy field engineering, stocking mode, water quality control, rice management, feeding, pest control and breeding management. However, more research is needed to standardize rice field engineering specifications, optimize coculture modes, clarify crab nutritional needs, develop disease prevention and control methods, elucidate the operational mechanism of rice‐crab coculture and ascertain energy‐material exchange with the external environment. Eventually, rice‐crab coculture can be highly integrated to utilize the fewest resources while providing the greatest economic and environmental benefits. This review provides a theoretical reference for further research in the field of rice‐crab coculture, examining aspects such as development history, economic benefits, organisms in the system (rice, crabs, plankton, zoobenthos, weeds and microorganisms), internal and external environmental benefits, and the direction of future development.
Cloprostenol enhances sexual behaviour and semen quality in growing lambs more effectively than Dinoprost
Authors: Sánchez‐Dávila Fernando , Hernández‐Melo Víctor Adrián , Ledezma‐Torres Rogelio Alejandro , Bernal‐Barragán Hugo , Luna‐Palomera Carlos , Ungerfeld Rodolfo 
Published: February 2022

AbstractAnalogues of PGF2α have been used in boars with positive results on sexual behaviour, but limited impact on semen quality. The objective of this study was to determine whether the administration of Dinoprost tromethamine or D‐Cloprostenol enhances the sexual behaviour and semen quality of sexually inexperienced growing lambs during the onset of the breeding season. The study lasted 10 weeks, beginning during the non‐breeding season, with 24 sexually inexperienced Katahdin lambs (5.1 ± 0.5 months old). Three groups of eight lambs each received: (1) vehicle treatment (group CON); (2) 10 mg of Dinoprost tromethamine (group DIN); or (3) 0.15 mg of Cloprostenol dextrogy (group CLOP). The treatments were all applied im 5 min before the tests of sexual behaviour, or 20 min before the collection of semen. Sexual behaviour was evaluated twice weekly in a pen test with a non‐oestrous ewe, and semen was collected once weekly with an artificial vagina. The latency to begin courtship was significantly shorter in both groups that received analogues of PGF2α than in CON lambs. The number of ano‐genital sniffs, flehmens and lateral approaches was greater in both treated groups than in CON lambs (p < .05). Lambs from DIN group mounted significantly more than CLOP and CON lambs, which did not differ. However, CLOP lambs showed significantly greater mating efficiency (i.e. ejaculations/total mounts) than CON lambs, which exhibited significantly greater mating efficiency that DIN lambs. Lambs treated with CLOP produced significantly more semen volume with more mass motility than those treated with DIN and CON (without differences between DIN and CON). Overall, we concluded that the administration of cloprostenol or dinoprost before sexual evaluation in young rams enhances their sexual behaviour. Cloprostenol had greater effects than dinoprost. The administration of cloprostenol before semen collection also triggered the ejaculation of a greater volume of semen, with greater mass motility. These results open interesting possibilities to study deeply the use of simple and cost‐effective treatments to improve the reproductive results of young growing rams.
Foreign direct investment, innovation, and domestic value‐added in exports: Firm‐level evidence from China
Authors: Lu Yue , Deng Lijing , Zeng Ka 
Published: February 2022

AbstractThis paper analyzes the effect of foreign direct investment (FDI) entry on the domestic value‐added ratio (DVAR) in exports using data on Chinese firms between 2000 and 2007. We adopt the difference‐in‐difference method to estimate instrumental variables regressions, treating the adoption of the Revisions to the Catalogue for the Guidance of Foreign Investment Industries in 2002 as a policy shock. Our analysis yields a few findings. First, FDI entry suppresses firm DVAR, a result that continues to hold after taking into consideration the randomness of the policy treatment group, other policy shocks, firm entry and exit, and the use of alternative measures. Second, FDI entry exerts a greater impact on the DVAR of foreign rather than domestic firms, non‐state‐owned enterprises (SOEs) rather than SOEs, and firms located in the eastern rather than central and western regions. Third, FDI entry negatively affects DVAR mainly through its horizontal spillovers after taking into account FDI entry in upstream and downstream industries. Fourth, compared to FDI from Hong Kong, Macao, and Taiwan (HMT), foreign investments from non‐HMT regions are less likely to inhibit firm DVAR. Lastly, we find that value capture capacity, as measured by firm innovation, plays an important role in mediating the impact of FDI entry on DVAR. Taken together, these findings suggest that sustainable domestic economic development cannot rely solely on the introduction of foreign investment and should instead emphasize the importance for firms to improve value capture capacity so as to better capitalize on the positive spillovers generated by foreign investment.
Unravelling a 2300 year long sedimentary record of megathrust and intraslab earthquakes in proglacial Skilak Lake, south‐central Alaska
Authors: Praet Nore , Van Daele Maarten , Moernaut Jasper , Mestdagh Thomas , Vandorpe Thomas , Jensen Britta J. L. , Witter Robert C. , Haeussler Peter J. , De Batist Marc 
Published: February 2022

AbstractSeismic hazards in subduction settings typically arise from megathrust, intraslab and crustal earthquake sources. Despite the frequent occurrence of intraslab earthquakes in subduction zones and their potential threat to communities, their long‐term recurrence behaviour is barely studied. Sedimentary sequences in lakes may register ground shaking from different seismic sources. This study investigates two long sediment cores (13 m and 16 m) from Skilak Lake, a proglacial lake in south‐central Alaska, to evaluate whether different seismic sources leave a distinct imprint. The sedimentary record shows a continuously varved sediment sequence, occasionally interrupted by turbidites, slump deposits and tephra beds. Turbidites and slump deposits were objectively identified using a statistical outlier analysis on varve thickness. The earthquake origin of these deposits was ascertained by resemblance with deposits induced by instrumentally recorded earthquakes (for example, 1964 ce Mw 9.2 megathrust and 1954 ce Mw 6.4 intraslab earthquakes) and correlation with multiple coeval landslide deposits on sub‐bottom profiles. The Skilak Lake record chronicles 19 earthquakes with moderate to very high confidence level in the past 1350 years. The sedimentary evidence of instrumentally‐recorded intraslab and megathrust earthquakes within the past 70 years demonstrates that not only megathrust earthquakes, but also past intraslab events are recorded. Although reported seismic intensities at Skilak Lake are comparable for the 1964 ce megathrust and the 1954 ce intraslab earthquakes, the long duration and low frequency content of seismic ground motion during megathrust earthquakes facilitate the triggering of multiple, voluminous landslides and the generation of megaturbidites. In contrast, the shorter duration and higher frequency source spectrum of intraslab earthquakes may only induce surficial slope remobilization and the generation of thinner turbidites. This study demonstrates that the sedimentary record of Skilak Lake has the potential to decipher multiple seismic sources, which opens possibilities for a comprehensive seismic hazard analysis for south‐central Alaska.