bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiorespiratory Fitness and Bone Turnover Markers in Adults With Metabolic Syndrome: The Mediator Role of Inflammation
Authors: Gil-Cosano José J. , Gracia-Marco Luis , Courteix Daniel , Lesourd Bruno , Chapier Robert , Obert Philippe , Walther Guillaume , Vinet Agnes , Thivel David , Muñoz-Torres Manuel , Ugbolue Ukadike C. , Bagheri Reza , Zak Marek , Dutheil Frédéric , Ubago-Guisado Esther 
Published: October 2022

The relationship between inflammatory markers and bone turnover in adults is well known, and a negative association between cardiorespiratory fitness (CRF) and inflammatory markers has also been described. Hence, we tested whether the association between CRF and bone turnover markers is mediated by inflammatory markers in adults with metabolic syndrome. A total of 81 adults (58.5 ± 5.0 years, 62.7% women) were included in the analysis. CRF was measured by the 6-min walking test. Serum interleukin (IL)-1β, IL-6, IL-10, tumor necrosis factor alpha, high-sensitivity c-reactive protein (hsCRP) and vascular endothelial growth factor, collagen type I cross-linked C-telopeptide, procollagen type I N-terminal propeptide (P1NP), and total osteocalcin were assessed using a sensitive ELISA kit. Body composition was assessed by dual-energy X-ray absorptiometry. Partial correlation was used to test the relationship between CRF, inflammatory markers, and bone turnover markers, controlling for sex, lean mass, and fat mass. Boot-strapped mediation procedures were performed, and indirect effects with confidence intervals not including zero were interpreted as statistically significant. CRF was positively correlated with P1NP levels (r = .228, p = .044) and osteocalcin levels (r = .296, p = .009). Furthermore, CRF was positively correlated with IL-1β levels (r = .340, p = .002) and negatively correlated with hsCRP levels (r = −.335, p = .003), whereas IL-1β levels were positively correlated with P1NP levels (r = .245, p = .030), and hsCRP levels were negatively correlated with P1NP levels (r = −.319, p = .004). Finally, the association between CRF and P1NP levels was totally mediated by hsCRP (percentage of mediation = 39.9). Therefore, CRF benefits on bone formation could be dependent on hsCRP concentrations in this population.
Impact of 24-Hr Diet and Physical Activity Control on Short-Term Precision Error of Dual-Energy X-Ray Absorptiometry Physique Assessment
Authors: Slater Gary J. , Farley Ava , Hogarth Luke , Areta Jose L. , Paulsen Gøran , Garthe Ina 
Published: October 2022

Dual-energy X-ray absorptiometry (DXA) is a popular technique used to quantify physique in athletic populations. Due to biological variation, DXA precision error (PE) may be higher than desired. Adherence to standardized presentation for testing has shown improvement in consecutive-day PE. However, the impact of short-term diet and physical activity standardization prior to testing has not been explored. This warrants investigation, given the process may reduce variance in total body water and muscle solute, both of which can have high daily flux amongst athletes. Twenty (n = 10 males, n = 10 females) recreationally active individuals (age: 30.7 ± 7.5 years; stature: 176.4 ± 9.1 cm; mass: 74.6 ± 14.3 kg) underwent three DXA scans; two consecutive scans on 1 day, and a third either the day before or after. In addition to adhering to standardized presentation for testing, subjects recorded all food/fluid intake plus activity undertaken in the 24 hr prior to the first DXA scan and replicated this the following 24 hr. International Society of Clinical Densitometry recommended techniques were used to calculate same- and consecutive-day PE. There was no significant difference in PE of whole-body fat mass (479 g vs. 626 g) and lean mass (634 g vs. 734 g) between same- and consecutive-day assessments. Same- and consecutive-day PE of whole-body fat mass and lean mass were less than the smallest effect size of interest. Inclusion of 24-hr standardization of diet and physical activity has the potential to reduce biological error further, but this needs to be verified with follow-up investigation.
Local rapid exhumation during the long-lived Grenville orogeny
Authors: Fan Xuefei , Chu* Xu , Cao Wentao , Zou Yi 
Published: October 2022

ABSTRACT
The Grenville Province is the largest and most structurally complex orogenic belt that formed in the Mesoproterozoic, representing the amalgamation of the supercontinent Rodinia. The Mattawa domain, part of the Algonquin domain in Ontario, Canada, hosts some of the most deeply buried metamorphic rocks of this orogen. This high-grade metamorphic terrane consists of large areas of felsic orthogneiss and kilometer-sized mafic boudins. Dark-colored metabasite cropping out near Mattawa, Ontario, Canada, contains relict mineral assemblages and decompression textures indicative of high-pressure eclogite. Garnet porphyroblasts surrounded by plagioclase coronae are hosted in fine-grained symplectic intergrowths of diopside + plagioclase ± amphibole, which compositionally reintegrated into an omphacite composition (Na/[Na + Ca] ~0.5). Phase equilibria analysis revealed an eclogite-facies peak pressure of ~2 GPa at 850 °C. This temperature is consistent with the zirconium contents of rutile inclusions in garnet (up to 1725 ppm Zr). Despite high-temperature metamorphism, garnet growth zonation is partially preserved. Diffusion modeling of representative garnet profiles yielded a time scale of &lt;0.1 m.y. for decompression from the peak pressure to ~1.2 GPa, suggesting an average exhumation rate of several decimeters per year. Decompression was followed by fast cooling within hundreds of thousands of years. Such fast decompression and cooling rates contrast with the protracted metamorphic evolution recorded in most of the Grenville orogen and likely resulted from local extrusion of lower-crustal material in response to localized extension during the early Ottawan stage. Since very few examples of Precambrian short-duration regional metamorphism have been documented, the fast decompression documented in this study provides valuable constraints for the geodynamic transition to a modern plate-tectonic regime.
Kidney transplantation from an HIV-positive deceased donor to an HIV-positive recipient
Authors: Lyngberg-Larsen Christiane , Lund Laursen Alex , Øzbay Lara Aygen 
Published: October 2022

Preliminary data on HIV-positive donor to HIV-positive recipient kidney transplantation suggest promising patient outcomes without adverse events. This is an important step in expanding the donor pool and opportunity for transplantation in HIV-positive patients.We herein report the first case of HIV-positive donor to HIV-positive recipient kidney transplantation in Denmark. Our patient has demonstrated a successful post-transplant course with excellent 1-year graft function, no rejection episodes, good virological control with undetectable HIV RNA, no signs of HIV-associated nephropathy, and no superinfections or opportunistic infections.This case corroborates findings from previous studies showing that kidney transplantation from carefully selected HIV-infected donors to carefully selected HIV-infected recipients seems to be a safe and effective treatment option, and supports the opportunity to expand the organ donor pool for this group of patients with end-stage renal disease.
Effects of reducing sedentary behaviour duration by increasing physical activity, on cognitive function, brain function and structure across the lifespan: a systematic review protocol
Authors: Pindus Dominika M , Selzer-Ninomiya Ana , Nayak Apurva , Pionke JJ , Raine Lauren B 
Published: October 2022

IntroductionGreater engagement in sedentary behaviours has been related to poorer cognitive functions in epidemiological research. However, the effects of reducing sedentary behaviour duration on cognitive function, brain function, and structure remain poorly understood. This systematic review aims to synthesise the evidence on the effects of reducing sedentary behaviour duration by increasing time spent in physical activity on cognitive function, brain structure and function in apparently healthy children, adolescents and adults.Methods and analysisThe protocol follows Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The literature search will be conducted (search dates: August–September 2022) across six databases: PubMed, Scopus, Cumulative Index to Nursing and Allied Health Literature (via EBSCO Host), PsycINFO (via ProQuest), SPORTDiscus and Web of Science (Science and Social Science Citation Index). The inclusion criteria are as follows: randomised and non-randomised experimental studies as defined by the Cochrane Handbook, published in English, in peer-reviewed journals, and as theses or dissertations. References of included papers will be screened for additional studies. Acute and chronic interventions targeting children (≥ 4 years), adolescents, younger adults (≥ 18–40 years), middle-aged (40–64 years) and older adults (65+ years) will be eligible. Methodological quality will be assessed with the Effective Public Health Practice Project quality assessment tool for quantitative studies. Qualitative synthesis will be stratified by intervention type (acute vs chronic), intervention content (reducing sedentary time or interrupting prolonged sitting) and outcome (cognitive, brain structure and function).Ethics and disseminationNo primary data collection will be conducted as part of this systematic review. Study findings will be disseminated through peer-reviewed publications, conference presentations and social media.PROSPERO registration numberCRD42020200998.
Safety, tolerability, pharmacokinetics and preliminary antitumour activity of an antisense oligonucleotide targeting STAT3 (danvatirsen) as monotherapy and in combination with durvalumab in Japanese patients with advanced solid malignancies: a phase 1 study
Authors: Nishina Tomohiro , Fujita Tomoko , Yoshizuka Naoto , Sugibayashi Ko , Murayama Kosho , Kuboki Yasutoshi 
Published: October 2022

ObjectivesWe assessed the safety, tolerability, pharmacokinetics, preliminary antitumour activity and pharmacodynamics of danvatirsen, an antisense oligonucleotide targeting signal transducer and activator of transcription 3 (STAT3), monotherapy and danvatirsen plus durvalumab, an antiprogrammed cell death ligand 1 monoclonal antibody, in patients with advanced solid malignancies.DesignPhase 1, open-label study with two cohorts.SettingTwo centres in Japan.ParticipantsJapanese individuals aged ≥20 years, with histologically confirmed solid malignancies, except for hepatocellular carcinoma, refractory to standard therapy.InterventionsIn cohort 1, patients received danvatirsen monotherapy; in cohort 2, patients received danvatirsen plus durvalumab combination therapy.Primary and secondary outcome measuresThe primary endpoint was safety and tolerability based on adverse events (AEs). Secondary endpoints were pharmacokinetics, immunogenicity, antitumour activity and pharmacodynamics.ResultsEleven patients were assigned to treatment and included in the analysis. Danvatirsen dose reductions were only required in cohort 2 for hepatic function abnormal (alanine aminotransferase (ALT)/ aspartate aminotransferase (AST)/gamma-glutamyl transferase (γGT) increased), neutrophil count decreased and platelet count decreased. One patient experienced grade 3 ALT/AST increased and new appearance of eosinophilia as a dose-limiting toxicity. AEs were reported in 90.9% (10/11) patients. Commonly reported AEs causally related to the danvatirsen were platelet count decreased (60% (3/5)) and ALT/AST/γGT increased (50% (3/6)) in cohorts 1 and 2, respectively; none was causally related to durvalumab. One serious AE occurred in cohort 1 (pancreatitis; unrelated to study treatment). One case of ALT/AST/γGT increased occurred in cohort 2, leading to discontinuation. No AEs led to death. Danvatirsen did not accumulate in plasma after multiple dosing. In cohort 2, three patients had disease control at 12 weeks and one had unconfirmed partial response. STAT3 expression tended to decrease regardless of monotherapy or combination therapy.ConclusionsDanvatirsen was well tolerated by Japanese patients with advanced solid tumours as monotherapy and combined with durvalumab. No new safety signals arose.Trial registration numberNCT03394144; ClinicalTrials.gov.
Community determinants of COPD exacerbations in elderly patients in Lodz province, Poland: a retrospective observational Big Data cohort study
Authors: Kowalczyk Anna , Kosiek Katarzyna , Godycki-Cwirko Maciek , Zakowska Izabela 
Published: October 2022

ObjectivesTo evaluate the prevalence and identify demographic, economic and environmental local community determinants of chronic obstructive pulmonary disease (COPD) exacerbations in elderly in primary care using Big Data approach.DesignRetrospective observational case–control study based on Big Data from the National Health Found, Tax Office and National Statistics Center databases in 2016.SettingPrimary care clinics in the Lodz province in Poland.Participants472 314 patients aged 65 and older in primary care, including 17 240 patients with COPD and 1784 with exacerbations (including deaths).Outcome measuresExacerbations with demographic, economic and environmental local community determinants were retrieved. Conditional logistic regression for matched pairs was used to evaluate the local community determinants of COPD exacerbations among patients with COPD.ResultsThe overall prevalence of COPD in the population of elderly patients registered in primary healthcare clinic clinics in Lodz province in 2016 was 3.65%, 95% CI (3.60% to 3.70%) and the prevalence of exacerbations was 10.35%, 95% CI (9.89% to 10.80%). The high number of consultations in primary care clinics was associated with higher risk of COPD exacerbations (p=0.0687).High-income patients were less likely to have exacerbations than low-income patients (high vs low OR 0.601, 95% CI (0.385 to 0.939)). The specialisation of the primary care physician did not have an effect on exacerbations (OR 1.076, 95% CI (0.920 to 1.257)). Neither the forest cover per gmina (high vs low OR 0.897, 95% CI (0.605 to 1.331); medium vs low OR 0.925, 95% CI (0.648 to 1.322)), nor location of gmina (urban vs urban–rural OR 1.044; 95% CI (0.673 to 1.620)), (rural vs urban–rural OR 0.897, 95% CI (0.630 to 1.277)) appears to influence COPD exacerbations.ConclusionsBig Data statistical analysis facilitated the evaluation of the prevalence and determinants of COPD exacerbation in the elderly residents of Lodz province, Poland.Modification of identified local community determinants may potentially decrease the number of exacerbations in elderly patients with COPD.
COVID-19 vaccination status and associated factors among lactating women during the COVID-19 outbreak: a cross-sectional study in southern China
Authors: Wang Xiaofen , Tang Kun , Huang Rong , Yi Simin 
Published: October 2022

ObjectivesDifferent countries and institutions around the world have debated whether lactating women should receive the COVID-19 vaccine during the COVID-19 pandemic. In China, lactating is not a contraindication to vaccination, but many women are still hesitant to get vaccinated. The purpose of this study was to investigate the current status of COVID-19 vaccination among lactating women and the related factors affecting vaccination.MethodsAn online cross-sectional survey involving 506 lactating women was conducted in southern China. We explored the related factors affecting COVID-19 vaccination of lactating women from three aspects: general information, knowledge–attitude–behaviour towards COVID-19 and its vaccine, and postpartum psychological state.ResultsA total of 432 lactating women completed the questionnaire, 198 of whom had received the COVID-19 vaccine. On the knowledge–attitude–behaviour questionnaire on COVID-19 and its vaccines, the vaccinated group scored higher than the unvaccinated group on both the three subdimensions of the questionnaire and the total score (p<0.01). The results of binary logistics regression analysis showed that mixed feeding (OR=2.68, 95% CI: 1.82 to 3.96), longer breastfeeding duration (OR=1.31, 95% CI: 1.16 to 1.49), better physical condition (OR=5.28, 95% CI: 1.82 to 15.32), higher attitude score of COVID-19 and its vaccine (OR=1.18, 95% CI: 1.10 to 1.27), and having a travel history in medium high-risk areas (OR=3.49, 95% CI: 1.46 to 8.37) were significantly associated with COVID-19 vaccination in lactating women. Having a master’s degree or above (OR=0.03, 95% CI: 0.01 to 0.30), and having higher anxiety score (OR=0.66, 95% CI: 0.54 to 0.81) and depression score (OR=0.84, 95% CI: 0.75 to 0.93) were inversely associated with COVID-19 vaccination in lactating women.Conclusion45.8% of lactating women were vaccinated against COVID-19. Education level, feeding methods, duration of breast feeding, travel history in medium high-risk areas, physical condition, attitude score of COVID-19 and its vaccine, anxiety symptom and depressive symptom score were associated with vaccination of lactating women. More interventions based on these factors were needed to reduce concerns for lactating women and increase their vaccination rates.
Aerobic fitness predicted by demographics, anthropometrics, health behaviour, physical activity and muscle fitness in male and female recruits entering military service
Authors: Santtila Matti , Pihlainen K , Vaara J , Nindl B C , Heikkinen R , Kyröläinen H 
Published: October 2022

IntroductionThe physical and mental training load can be high during military service. Therefore, tailored preconditioning programmes based on assessment of physical fitness could increase readiness for military service, especially among those ones with lower baseline fitness level. The purpose of present study was to investigate how self-assessed health behaviour, physical activity and muscle fitness can predict physical fitness in young male and female military cohorts.MethodsDemographics, health behaviour and daily physical activity preceding military service were surveyed by a questionnaire. Thereafter, physical fitness was assessed during the military service by the tests of 12 min running, 1 min push-ups and sit-ups. Explosive power of the lower extremities was studied by maximal standing long jump. Measurements of body anthropometry consisted of body mass, height, and waist circumference.ResultsThe two strongest individual predictors of objectively measured running distance in 12 min were self-reported physical activity and physical readiness in both men and women. Self-reported physical activity, readiness for military service, sitting time, education, smoking and body anthropometrics together explained 52% of the variance in the 12 min running test result (R2=0.52, mean absolute percentage error (MAPE) 8.8%, mean absolute error (MAE) 207 m) in men, while for women the predictive values were weaker. Addition of muscle fitness results to the adjusted regression model further improved the model, which explained 59% of the variance in the 12 min running tests result of male conscripts (R2=0.59, MAPE 7.8%, MAE 181 m).ConclusionIn the present study, self-reported physical activity, muscle fitness, physical readiness for military service, sitting time, education, smoking and body anthropometrics predicted inadequately the measured endurance capacity among recruits. The present questionnaire-based variables do not accurately predict physical fitness of recruits and thus, they are not either suitable for practical use for preconditioning programmes or preselection before entering the military service.
Tobacco industry’s human rights makeover: an archival review of British American Tobacco’s human rights rhetorical veneer
Authors: Sircar Neiloy R , Bialous Stella A. 
Published: October 2022

BackgroundBritish American Tobacco (BAT) released an industry-first human rights report in 2020, which extolled the efforts and objectives of the tobacco industry giant for promoting human rights. How BAT came to brand itself as a human rights champion, being a leader in an industry long accused of enabling human rights violations from leaf-to-stub including profiting from a product which inherently violates the right to health, is unknown. Exploring BAT’s evolution through reviewing its materials and Tobacco Industry Documents could shed light on their development and what it means in the tobacco control and human rights context.MethodologyWe reviewed publicly available materials from BAT as well as conducted archival research in the Tobacco Industry Documents digital archives at University of California San Francisco. We focused on how and when BAT used terms such as ‘human rights’, ‘right to health’, ‘sustainable development goal’ and ‘harm reduction’ as well as ‘Framework Convention on Tobacco Control’.ResultsWe reviewed 48 BAT publications and 45 documents from the Tobacco Industry Documents archives. These materials demonstrate both BAT’s increasing utilisation of human rights language as well as BAT’s reuse of the same language, concepts and general rhetoric. BAT has not engaged significantly or meaningfully on the human right to health.ConclusionBAT’s increasing use of human rights rhetoric does not appear to reflect a shift in the company’s human rights positions, particularly with respect to the right to health of consumers and BAT’s lack of impactful measures to eliminate the harms of its tobacco products.
Dynamical cooperation model for mitigating the segregation phase in Schelling’s model
Authors: Okada Akihisa , Inoue Daisuke , Koyama Shihori , Matsumori Tadayoshi , Yoshida Hiroaki 
Published: October 2022

Abstract
We consider a Schelling-like segregation model, in which the behavior of individual agents is determined by a mixed individual and global utility. With a high ratio of global utility being incorporated, the agents are cooperative in order to realize a homogenized state, otherwise the agents are less cooperative, leading to an undesired Nash equilibrium with low utility. In the present study, we introduce a dynamically varying cooperation degree parameter to prevent the agents from falling into such a low-utility equilibrium state. More precisely, a large cooperation degree is assigned when the agents are in high-utility regions, whereas agents having low utility behave more individually. Simulation results show that homogenized phases with globally high utility are achieved with the present dynamical control, even for the case of a low mean value of cooperation degree. Since the cooperation degree represents the magnitude with which Pigouvian tax is enforced in the model of residential movement within a city, this result suggests the possibility of tax intervention to circumvent the undesired segregation of the residents.

Graphical abstract
Averaged recurrence quantification analysis
Authors: Pánis Radim , Adámek Karel , Marwan Norbert 
Published: October 2022

AbstractRecurrence quantification analysis (RQA) is a well established method of nonlinear data analysis. In this work, we present a new strategy for an almost parameter-free RQA. The approach finally omits the choice of the threshold parameter by calculating the RQA measures for a range of thresholds (in fact recurrence rates). Specifically, we test the ability of the RQA measure determinism, to sort data with respect to their signal to noise ratios. We consider a periodic signal, simple chaotic logistic equation, and Lorenz system in the tested data set with different and even very small signal-to-noise ratios of lengths $$10^2, 10^3, 10^4,$$

10
2

,

10
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,

10
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and $$10^5$$

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. To make the calculations possible, a new effective algorithm was developed for streamlining of the numerical operations on graphics processing unit (GPU).