bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribution of impaired DNASE1L3 activity to anti-DNA autoantibody production in systemic lupus erythematosus
Authors: Mathapathi Samarth , Chu Cong-Qiu 
Published: April 2022

Abstract
Anti-DNA autoantibodies are pathogenic in systemic lupus erythematosus (SLE). Cell-free chromatin associated long DNA fragments are antigens for anti-DNA antibodies. In health state, released by cell death and actively secreted by live cells, these cell-free DNA are cleared by deoxyribonucleases (DNASES). In SLE, cell-free DNA are accumulated. The defective clearance of long fragments of cell-free DNA in SLE is largely attributed to impaired deoxyribonuclease 1 like 3 (DNASE1L3). DNASE1L3 null mutation results in monogenic SLE. The SLE risk single-nucleotide polymorphism (rs35677470) encodes R260C variant DNASE1L3, which is defective in secretion, leading to reduced levels of DNASE1L3. In addition, neutralizing autoantibodies to DNASE1L3 are produced in SLE to inhibit its enzymatic activity.
Antitumor Effect of the Synthesized Chalcone Analogues on HeLa Cell Line
Authors: Anđelković Marija , Nikolić Ivana , Luković Jovan , Mitrović Marina , Zelen Ivanka , Muškinja Jovana , Ratković Zoran , Popović Suzana , Stanković Sanja , Pirković Marijanа Stanojević 
Published: April 2022

Abstract
Chalcones represent a type of flavonoids which are located at vegetative and reproductive organs of plants and they can be metabolic progenitor molecules for several flavonoids and isoflavonoids. Many studies indicated that molecular structure of chalcone accountable for their anti-tumor, anti-inflammatory and anti-oxidant effects. The aim of our research was to investigate anti-tumor effect and mechanism of action of three synthesized chalcone analogues on HeLa cells. The anti-tumor effectiveness of chalcone analogues was compared to effects of the dehydrozingerone and cisplatin that were used as referent substances.
The viability of the treated cells was evaluated using MTT assay. Evaluation of cell death was determined by flow cytometry and cells were stained with Annexin V-FITC/7-AAD. The result of our research indicated that used chalcones have stronger antitumor effect relative to the dehydrozingerone and cisplatin.
The IC50 values of the chalcones ranged between 1.69-6.18 μM, with CH1 being more cytotoxic after 24 h of treatment, while CH3 being more cytotoxic after 48 h of treatment on HeLa cells. All investigated chalcones induced apoptosis in HeLa cells via mitochondrial pathway, which was detected expression Bax and Bcl- 2 proteins.
Our results provided evidence that chalcones induced apoptosis in HeLa cervical carcinoma through the intrinsic apoptotic pathway. These findings provide insights into the molecular mechanism of chalcones-induced cell death.
Efficient algorithm for solving the system of Allen–Cahn and Cahn–Hilliard equations: modeling the sintering process
Authors: Прохоров Д.И. , Базайкин Я.В. , Лисица В.В. 
Published: April 2022

В работе представлен алгоритм решения системы уравнений Аллена–Кана и Кана–Хиллиарда, которая описывает процесс спекания. Алгоритм не требует значительных по мощности вычислительных ресурсов и позволяет выполнить моделирование процесса спекания большого количества отдельных частиц на вычислительном узле с процессором Intel Xeon E5 2697 v3 и графическим ускорителем NVIDIA K40 за приемлемое время. Проведены эксперименты по моделированию спекания сорбентоподобных структур — упаковок сферических частиц, и на них показана эффективность алгоритма.
In this work, we present an algorithm for solving the system of Allen–Cahn and Cahn–Hilliard equations, which describes the process of sintering. The algorithm does not require significant computational resources and makes possible the sintering simulating of a large number of grains using a computation node with an Intel Xeon E5 2697 v3 CPU and an NVIDIA K40 GPU in a reasonable time. Experiments were carried out to simulate the sintering of sorbent-like structures (packings of spherical particles), for which the efficiency of the algorithm was shown.
Hybrid Controller based on Null Space and Consensus Algorithms for Mobile Robot Formation
Authors: Andaluz Gabriela M. , Leica Paulo , Herrera Marco , Morales Luis , Camacho Oscar 
Published: April 2022

This work presents a novel hybrid control approach based on null space and consensus algorithms to solve the scalability problems of mobile robot formation and improve leader control through multiple control objectives. In previous works, the training of robots based on the null space requires a rigid training structure based on a geometric shape, which increases the number of agents in the formation. The scheme of the control algorithm, which does not make formation scalability possible, must be changed; therefore, seeking the scalability of training based on null space is a challenge that could be solved with the inclusion of consensus algorithms, which allow the control structure to be maintained despite increasing or decreasing the number of robot followers. Another advantage of this proposal is that the formation of the followers does not depend on any geometric figure compared to previous works based on the null space; this new proposal does not present singularities as if the structure is based on geometric shape, the latter one is crucial since the formation of agents can take forms that cannot be achieved with a geometric structure, such as collinear locations, that can occur in many environments. The proposed hybrid control approach presents three tasks: i) leader position task, ii) leader shape task, and iii) follower formation task. The proposed algorithm is validated through simulations, performing tests that use the kinematic model of non-holonomic mobile robots. In addition, linear algebra and Lyapunov theory are used to analyze the stability of the method. Doi: 10.28991/ESJ-2022-06-03-01 Full Text: PDF
Managerial Recommendations Improving the Competitive Capability of Firms Based on Total Quality Management during Covid-19 Pandemic
Authors: Son Ha Van , Trai Nguyen Van , Tam Phan Thanh 
Published: April 2022

In 2021, the COVID-19 epidemic affected many aspects of the provinces' socio-economic fields, especially deeply affecting businesses at enterprises. The task of ensuring social security continues with the management agencies, who need appropriate solutions and support policies to encourage and help enterprises return to production and trade after the quarantine society quickly. The basis for management theory has contributed to improving the competitive capability based on improving Total Quality Management (TQM), such as the "just in time" system. TQM aims to enhance the quality of products and satisfy customers to the best extent possible. The distinguishing feature of TQM from previous quality management methods is that it provides a comprehensive system for managing and improving all aspects related to quality and involves the participation of the public, every department, and every individual to achieve the set quality goals. The article's novelty identifies factors influencing total quality management and competitive capability of firms in Vietnam with one percent significance. Methods: The authors surveyed 650 managers at many enterprises in Vietnam. And the authors used a convenient sampling method. SPSS tools processed 589 samples to measure Cronbach's alpha, exploratory factor analysis (EFA), confirmation factor analysis (CFA), and test structural equation modeling (SEM). The authors proposed several recommendations to enhance the total quality management and competitive capability of firms. Doi: 10.28991/ESJ-2022-06-03-010 Full Text: PDF
The Role of Economic Policy Uncertainty in Predicting Stock Return Volatility in the Banking Industry: A Big Data Analysis
Authors: Antonopoulou Hera , Mamalougou Vicky , Theodorakopoulos Leonidas 
Published: April 2022

The research aims to study the effects of economic policy uncertainty on the return volatility of stocks with data from the largest banking institutions in Greece. Volatility is constructed using intraday data, whereas the research period extends over a period of about thirteen years, more specifically from January 5, 2001, to June 30, 2014. This period includes various phases of the market, such as stock market crashes along with stock market booms (e.g. the financial crisis of 2007 and 2008 in the United States and the European sovereign debt crisis). The estimated regressions were used to indicate the direct effects of economic policy uncertainty on the return volatility of the stocks of the four large Greek banks. The volatility index is constructed based on intraday data, whereas four different estimators of volatility were used. There is a statistically significant "direct" effect of economic policy uncertainty on the volatility of stock returns of the largest Greek banks, which are (a) Alpha Bank, (b) Eurobank, (c) National Bank of Greece, and (d) Piraeus Bank. Such findings are highly important for specific groups of people, such as investors, policymakers, and regulators. This study is the first research that seeks to identify the effect of economic policy uncertainty on the stock return volatility of the Greek banking system, constructed from intraday data. Doi: 10.28991/ESJ-2022-06-03-011 Full Text: PDF
Effectiveness of Students' Motivation Factors in the Competency-Based Approach: A Case Study of Universities in Russia and Indonesia
Authors: . Nuphanudin , Komariah Aan , Shvetsova Tatiana , Gardanova Zhanna , Podzorova Marina , Kurniady Dedy Achmad , Gladysheva Marina , Dudnik Olesya , Taduran Richard Jonathan O. , Kosov Mikhail 
Published: April 2022

The study aimed to explore the influence of motivation factors on the development of professional competencies using Russian and Indonesian institutions of higher education as case studies. In pursuit of this objective, quantitative survey methodology was incorporated, and surveys were conducted during November and April of the 2018/2019 to 2021/2022 school years. The questionnaire was developed with a 10-point rating scale, aimed at addressing the development of students' professional competencies and the factors that motivate learning and competency development. Using the questionnaire, the level of professional competency development of students in Russian and Indonesian universities has been empirically analysed. The results of the study supported the spiral nature of students' professional competencies development, showing that the development of professional competencies follows a progressive and non-linear nature of component development. These results confirm that the process of professional competency development is structurally divided into separate, relatively independent stages reflecting sequential and gradual progression. The positive character of the influence of the balanced development level of intrinsic and extrinsic motivation factors on the formation of students' professional competencies has been established. The results of the research may prove useful for educational institutions and public administration bodies for the development of effective mechanisms for students' motivation within the framework of competency-based approach implementation in higher education. Doi: 10.28991/ESJ-2022-06-03-012 Full Text: PDF
An Empirical Study of Principals' Leadership Styles with Faculty Commitment
Authors: Nguyen Thanh Hai , Van Quang Nguyen , Tuyet Mai Nguyen Thị 
Published: April 2022

Objectives: The objectives of this study were to explore the leadership styles of political school principals and the influence of leadership styles on faculty committees, as well as the influence of leadership styles on faculty-directed demographic variables. Methods/Analysis: This study uses a quantitative method to identify the leadership styles that exist in principals of political schools. The collected data is analyzed and processed in the Statistical Package for Social Sciences (SPSS) version 26.0. The available test of Avolio and Bass to explore leadership styles, the test developed by Meyer and Allen is used to measure faculty commitment. Findings: Transformative leadership styles, transactional leadership styles, and laissez-faire leadership styles all have statistically significant positive correlations with faculty commitment. Novelty/Improvement: The laissez-faire leadership style had the strongest influence on faculty commitment, followed by the transformational leadership style. The least influential leadership style was the transactional leadership style. When lecturers have confidence and initiative, being able to make their own decisions and implement them, they will be more creative to achieve leadership performance. The research results are only shown within the provincial political schools of Vietnam. Future studies may select a broader sample of subjects in many educational institutions of a different kind. Doi: 10.28991/ESJ-2022-06-03-013 Full Text: PDF
Understanding Consumers' Purchase Intention and Gift-Giving in Live Streaming Commerce: Findings from SEM and fsQCA
Authors: Chen Wen-Kuo , Chen Chien-Wen , Silalahi Andri Dayarana K. 
Published: April 2022

Live streaming commerce has experienced tremendous growth over the past few years. Although research has increasingly investigated the phenomenon of live streaming as e-commerce, it is arguably essential to determine why consumers make purchases through live streaming and send paid gifts to streamers. This study aims to understand users' social commerce purchase intentions and gift-giving according to the uses and gratification perspective, and engagement, and extends the literature by identifying five uses and gratifications for social media live streaming and how the viewers' engagement affects purchase intentions and gift-giving. We tested the hypothesis among 525 Indonesians who watch live streaming through Structural Equation Modeling (SEM) and fuzzy set Qualitative Comparative Analysis (fsQCA). The results of SEM confirm the importance of pass-times and habits to consumer engagement in live streaming. In this sequence, the role of engagement (emotional, social presence, and immersion) was confirmed to significantly influence purchase intention and gift-giving intention. The results of fsQCA provide theoretical insight and practical suggestions for increasing our understanding of the complex interconnectivity among uses, gratification factors, engagement in social commerce purchase intentions, and gift-giving intentions. Finally, this study also highlighted the configurational conditions for understanding consumer behaviors in live streaming commerce. Doi: 10.28991/ESJ-2022-06-03-03 Full Text: PDF
Ansiedad y la somatización en adolescentes durante la pandemia del covid-19
Authors: Espinosa Gallardo Evelyn Mireya , Almeida Márquez Lucía 
Published: April 2022

El presente artículo permite conocer la relación entre la ansiedad y la somatización en adolescentes durante el contexto de la pandemia de la Covid-19. El diseño fue no experimental, con un enfoque cuantitativo-descriptivo correlacional. La muestra estuvo constituida por 204 adolescentes: 61,8% mujeres y 38,2% hombres entre 12 y 17 años de edad, bajo un muestreo por bola de nieve. Los instrumentos fueron: el Inventario de Ansiedad Estado-Rasgo (STAI) y el Listado de Síntomas Breve (LSB-50). Los resultados sociodemográficos mostraron que el 55,4% de la muestra, presentan miedo al Covid-19. En el análisis descriptivo de niveles de ansiedad existe un predominio del Nivel Moderado para la ansiedad, además en la variable de somatización se encontró que el 21,1% presenta riesgo psicosomático y psicológico, un 3,9 % requieren atención clínica y el 75,0% no presenta sintomatología. En el análisis de correlación se obtuvo un factor significativo moderado positivo entre la ansiedad estado y los síntomas psicosomáticos y psicológicos (LSB-50) de rho=,649 p<,001 R2=,421. Resultados similares para ansiedad rasgo con la variable de somatización rho=,715 p<,001 R2=,511.
OVERVIEW OF POSITIVE TRENDS AND WORLD EXPERIENCE IN THE PRESERVATION AND DEVELOPMENT OF SMALL TOWNS
Authors: Vahitov Damir , Astrahanceva Elena 
Published: April 2022

What is happening in the global economy change is inevitable ska-outlined the way forward on the situation of small and medium-sized cities, providing both positive and negative effects, providing new opportunities for the development or threatening the very existence of municipalities. The negative processes include the acceleration of planetary migration flows, the difference in the socio-economic development of different regions of the country, the geographical remoteness of settlements from each other, the unresolved problems of single-industry towns, as well as competition from megacities. At the same time, a number of positive processes (better environment, peace and quiet, affordable housing) make small and medium-sized cities an attractive place to stay and rest for many citizens of our country and foreigners. The contradictory trends suggest arguments for and against the consolidation of urban settlements.
Due to the ambiguity of the situation in the development of state programs for the development of urban areas of small and medium format, it is necessary to approach each specific case separately, taking into account the peculiarities of the population point, trying to preserve the diversity of urban construction in Russia. A skillful combination of state support and rapid response to global economic and social trends will enable the best way to realize the benefits of small and medium-sized cities.
Analytical support for modeling business processes in an organization
Authors: Aleksandrova Kseniya , Muzalev Sergey 
Published: April 2022

Background.
Business analysis is not widely used in today's enterprises, and the business analyst profession is relatively recent. At the same time, business analytics, and in particular the modeling of business processes, plays a huge role in managing the activities of an organization. Understanding the relationship between business processes provides significant opportunities for analyzing and planning business changes.
The modern market is not a market of quantity, but of the quality of the services provided, which is why there is a need to analyze existing business processes in order to form an effective enterprise management system. As a result of the analysis, the enterprise forms a system of indicators for evaluating the effectiveness of key business processes with the aim of their subsequent optimization, replacement or reengineering.
In general, the activity of the enterprise can be reduced to the identification of internal and external events that affect the efficiency of business processes.
The relevance of the topic lies in the fact that the timely detection of deviations from the requirements that affect the efficiency of existing business processes and their optimization allow the business to make effective decisions for its continued existence.
Methods.
The article discusses the main methods, algorithm and tools for analyzing business processes in the activities of enterprises.
Result.
The article discusses the methods of business process analysis, defines the problems of implementing business process analysis methods, discusses the procedures and algorithms used to address issues related to identifying problematic business processes.
Intellectual Capital Performance Of State-Owned Enterprises In Indonesia
Authors: Rachmawati Rima , Deliana Deliana , Lestari Rini 
Published: April 2022

Tujuan penelitian ini untuk mengukur kinerja pengelolaan modal intelektual di Badan Usaha Milik Negara dengan menggunakan model Pulic dikenal dengan Value Added Intellectual Capital. Data yang digunakan adalah laporan keuangan BUMN tahun 2020. Hasil kajian menunjukkan 10 BUMN dengan kategori top performance dan 11 BUMN dengan kategori bad performance. Implikasi penilaian ini mendorong BUMN untuk terus membenah dalam memanfaatkan modal intelektual untuk menciptakan nilai agar mampu bertahan dan memiliki daya saing di Era Pengetahuan saat ini.The purpose of this study is to measure the performance of intellectual capital management in State-Owned Enterprises using the Pulic’s model known as Value Added Intellectual Capital. The data used is the financial statements of SOEs for 2020. The results of the study show 10 SOE’s in the top performance category and 11 SOE’s in the bad performance category. The implications of this assessment encourage SOE’s to continue to improve in utilizing intellectual capital to create value in order to be able to survive and have competitiveness in the current Knowledge Age.
The influence of combinations of alien translocations on in vitro androgenesis in spring common wheat (Triticum aestivum L.)
Authors: Timonova E. M. , Adonina I. G. , Salina E. A. 
Published: April 2022

Backgr ound.The basic approach to the production of new common wheat genotypes involving introgressive hybridization entails a long-term process. Doubled haploid production could accelerate it. However, this method is not widely used in breeding programs due to its main limitation: the genotype dependence. Due to genetic differences between wheat and related species, it was assumed that alien genetic materials are different in their capacity to affect androgenesis. The effect of alien translocations on androgenesis has been shown earlier. The aim of this study was to develop a set of DH wheat lines containing a wheat-alien translocation in the genome and study the effect of alien translocations on androgenesis of anther culture in such lines.Materials and methods. The plant material included: the spring wheat cultivar ‘Novosibirskaya 16’, line Velut 991 carrying wheat-alien translocations 1RS.1BL from rye and 5BS.5BL-5SL from Aegilops speltoides Tausch, and four hybrid F3 generation lines (10-7, 14-8, 15-8, 15-12) from their crossing, differing in the content of alien translocations.Results.It was shown that parameters of androgenesis such as the number of embryo-like structures per 100 anthers, the number of albino regenerants per 100 anthers, and the number of green regenerants per 100 anthers varied depending on the line. The best -responding lines Velut 991, 10-7 and 14-8 are characterized by the presence of a 1RS.1BL wheat-rye translocation chromosome. Regeneration frequency of green plants was recorded to be 8,6%, 3,6% and 10,1% respectively. The values of the parameters for lines 15-12 (carrying 5BS.5BL-5SL translocation) and 15-8 (without translocations) did not differ significantly.Conclusion.Therefore, it can be concluded that the presence of the introgressive fragment of chromosome 5S did not affect the efficiency of androgenesis and the short shoulder of chromosome 1R carries genes that stimulated androgenesis in anther culture.