bluuebunny/crossref_metadata_2025_split huggingface dataset:
Practical suggestions for harms reporting in exercise oncology: the Exercise Harms Reporting Method (ExHaRM)
Authors: Spence Rosalind R , Sandler Carolina X , Jones Tamara L , McDonald Nicole , Dunn Riley M , Hayes Sandra C 
Published: December 2022

The volume of high-quality evidence supporting exercise as beneficial to cancer survivors has grown exponentially; however, the potential harms of exercise remain understudied. Consequently, the trade-off between desirable and undesirable outcomes of engaging in exercise remains unclear to clinicians and people with cancer. Practical guidance on collecting and reporting harms in exercise oncology is lacking. We present a harms reporting protocol developed and refined through exercise oncology trials since 2015.Development of the Exercise Harms Reporting Method (ExHaRM) was informed by national and international guidelines for harms reporting in clinical trials involving therapeutic goods or medical devices, with adaptations to enhance applicability to exercise. The protocol has been adjusted via an iterative process of implementation and adjustment through use in multiple exercise oncology trials involving varied cancer diagnoses (types: breast, brain, gynaecological; stages at diagnosis I–IV; primary/recurrent), and heterogeneous exercise intervention characteristics (face to face/telehealth delivery; supervised/unsupervised exercise). It has also involved the development of terms (such as, adverse outcomes, which capture all undesirable physical, psychological, social and economic outcomes) that facilitate the harms assessment process in exercise.ExHaRM involves: step 1: Monitor occurrence of adverse outcomes through systematic and non-systematic surveillance; step 2: Assess and record adverse outcomes, including severity, causality, impact on intervention and type; step 3: Review of causality by harms panel (and revise as necessary); and step 4: Analyse and report frequencies, rates and clinically meaningful details of all-cause and exercise-related adverse outcomes.ExHaRM provides guidance to improve the quality of harms assessment and reporting immediately, while concurrently providing a framework for future refinement. Future directions include, but are not limited to, standardising exercise-specific nomenclature and methods of assessing causality.
Implementation of systematic safety checklists in a neurocritical care unit: a quality improvement study
Authors: Escamilla-Ocañas César E , Torrealba-Acosta Gabriel , Mandava Pitchaiah , Qasim Muhammad Suhaib , Gutiérrez-Flores Bárbara , Bershad Eric , Hirzallah Mohammad , Venkatasubba Rao Chethan P , Damani Rahul 
Published: December 2022

Background and objectivesStructured and systematised checklists have been shown to prevent complications and improve patient care. We evaluated the implementation of systematic safety checklists in our neurocritical care unit (NCCU) and assessed its effect on patient outcomes.Design/methodsThis quality improvement project followed a Plan–Do–Study–Act (PDSA) methodology. A checklist for medication reconciliation, thromboembolic prophylaxis, glycaemic control, daily spontaneous awakening, breathing trial, diet, catheter/lines duration monitoring and antibiotics de-escalation was implemented during daily patient rounds. Main outcomes included the rate of new infections, mortality and NCCU-length of stay (LOS). Intervened patients were compared with historical controls after propensity score and Euclidean distance matching to balance baseline covariates.ResultsAfter several PDSA iterations, we applied checklists to 411 patients; the overall average age was 61.34 (17.39). The main reason for admission included tumour resection (31.39%), ischaemic stroke (26.76%) and intracerebral haemorrhage (10.95%); the mean Sequential Organ Failure Assessment (SOFA) score was 2.58 (2.68). At the end of the study, the checklist compliance rate throughout the full NCCU stays reached 97.11%. After controlling for SOFA score, age, sex and primary admitting diagnosis, the implementation of systematic checklists significantly correlated with a reduced LOS (ß=−0.15, 95% CI −0.24 to −0.06), reduced rate of any new infections (OR 0.59, 95% CI 0.40 to 0.87) and reduced urinary tract infections (UTIs) (OR 0.23, 95% CI 0.09 to 0.55). Propensity score and Euclidean distance matching yielded 382 and 338 pairs with excellent covariate balance. After matching, outcomes remained significant.DiscussionThe implementation of safety checklists in the NCCU proved feasible, easy to incorporate into the NCCU workflow, and a helpful tool to improve adherence to practice guidelines and quality of care measurements. Furthermore, our intervention resulted in a reduced NCCU-LOS, rate of new infections and rate of UTIs compared with propensity score and Euclidean distance matched historical controls.
Ratio of non-growing season to growing season N2O emissions in Canadian croplands: an update to national inventory methodology
Authors: Pelster David E. , Thiagarajan Arumugam , Liang Chang , Chantigny Martin H. , Wagner-Riddle Claudia , Congreves Kate , Lemke Reynald , Glenn Aaron , Tenuta Mario , Hernandez-Ramirez Guillermo , Bittman Shabtai , Hunt Derek , Owens Jennifer , MacDonald Douglas 
Published: December 2022

National inventory reporting of agricultural nitrous oxide (N2O) emissions in Canada is based primarily on measurements obtained using static chambers. In regions with cold winters and an accumulated snowpack (including Canada), these measurements tend to focus on the growing season (typically May–October). However, research has shown that emissions continue throughout the non-growing season (NGS) and that these account for a significant proportion of annual emissions. In the Canadian National Inventory NGS emissions currently are assumed to be adequately captured in western Canada, while they are accounted for in eastern Canada by multiplying the growing season emissions by a correction factor of 1.4, a value that was derived based on a limited number of measurements. Here we use recent Canadian studies to validate this correction factor. We collected data from available Canadian studies that measured soil N2O emissions from agricultural systems for the entire year and determined the proportion of these emissions that occurred during the NGS. The proportion of annual N2O emissions that occurred during the NGS varied widely, ranging from −4% to 119% with a mean of 35.5%, compared to the previous estimate of 30%. Due to high variability, few differences were observed between means associated with climatic, soil, and management variables. To correct for NGS N2O emissions from Canadian agricultural soils, we suggest that the current correction factor for converting growing season to total annual emissions be changed from 1.4 to 1.55 and that this be used for all agricultural soils in Canada rather than just eastern Canada.
Quintessence dark energy from strongly-coupled higgs mass gap: local and non-local higher-derivative non-perturbative scenarios
Authors: Frasca Marco , Ghoshal Anish , Koshelev Alexey S. 
Published: December 2022

AbstractWe entertain the possibility that dark energy arises from the Higgs field of quintessence type in the non-perturbative regimes. For this purpose we utilize a set of exact solutions of Higgs field theory recently devised, in terms of Jacobi elliptical function for a massless quartic scalar field, that satisfy a massive dispersion relation. In certain regions of the parameter space, determined by the quartic coupling value, we show that such solutions have the property to give the correct behavior for the equation of state of the dark energy depending on the initial $$\theta $$
θ
value of periodicity of the Jacobi elliptical function solution. It is seen that on a time scale determined by the Hubble constant and the strength of the self-interaction of the scalar field, when conformal invariance is restored, the equation of state for the dark energy becomes manifest. Further we investigate scenarios within standard field theory framework and also extending to higher-derivative theories, namely infinite-derivative theory, motivated from p-adic string field theory, and Lee–Wick theories and in all cases, we find suitable choices of the parameter space leads to dark energy behavior of the Higgs field, which we compare.
A Primer on Topological Data Analysis to Support Image Analysis Tasks in Environmental Science
Authors: Ver Hoef Lander , Adams Henry , King Emily J. , Ebert-Uphoff Imme 
Published: December 2022

Abstract
Topological data analysis (TDA) is a tool from data science and mathematics that is beginning to make waves in environmental science. In this work, we seek to provide an intuitive and understandable introduction to a tool from TDA that is particularly useful for the analysis of imagery, namely, persistent homology. We briefly discuss the theoretical background but focus primarily on understanding the output of this tool and discussing what information it can glean. To this end, we frame our discussion around a guiding example of classifying satellite images from the sugar, fish, flower, and gravel dataset produced for the study of mesoscale organization of clouds by Rasp et al. We demonstrate how persistent homology and its vectorization, persistence landscapes, can be used in a workflow with a simple machine learning algorithm to obtain good results, and we explore in detail how we can explain this behavior in terms of image-level features. One of the core strengths of persistent homology is how interpretable it can be, so throughout this paper we discuss not just the patterns we find but why those results are to be expected given what we know about the theory of persistent homology. Our goal is that readers of this paper will leave with a better understanding of TDA and persistent homology, will be able to identify problems and datasets of their own for which persistent homology could be helpful, and will gain an understanding of the results they obtain from applying the included GitHub example code.

Significance Statement
Information such as the geometric structure and texture of image data can greatly support the inference of the physical state of an observed Earth system, for example, in remote sensing to determine whether wildfires are active or to identify local climate zones. Persistent homology is a branch of topological data analysis that allows one to extract such information in an interpretable way—unlike black-box methods like deep neural networks. The purpose of this paper is to explain in an intuitive manner what persistent homology is and how researchers in environmental science can use it to create interpretable models. We demonstrate the approach to identify certain cloud patterns from satellite imagery and find that the resulting model is indeed interpretable.
Does Extended Sawyer–Eliassen Equation Effectively Capture the Secondary Circulation of a Simulated Tropical Cyclone?
Authors: Ji Dong , Qiao Fangli 
Published: December 2022

Abstract
The validity of the gradient wind balance in a tropical cyclone (TC) remains controversial, especially for the boundary layer and the upper outflow layer, even though this balance is assumed in the derivation of the Sawyer–Eliassen (SE) equation. This study derives an extended SE equation with the relaxation of the gradient wind and hydrostatic balance in cylindrical r–z coordinates, and then we diagnose the secondary circulation using this unbalanced SE equation and the azimuthally averaged tangential wind and thermodynamical fields from a three-dimensional numerical simulation of an intensifying TC. The gradient wind and hydrostatic imbalance produce two additional time-dependent forcing terms on the right-hand side (rhs) of SE equation, which are proved to be negligible for diagnosing the secondary circulation, even as the storm evolves rapidly. The use of the unbalanced basic state deforms the fields of coefficients that appear in the SE equation, and thus the forced secondary flows. The results indicate that the unbalanced solution captures the boundary layer inflow better than the balanced solution described by Bui et al. and the pseudobalanced solution described by Heng et al. The unbalanced solution is closer to the simulation because more unbalanced components are included. Many previous studies always employ the thermal wind balance relation to simplify the SE equation, which is invalid in an unbalanced vortex and result in an overestimation of the boundary layer inflow. These unbalanced dynamics could provide a reliable diagnosis of the secondary flow near the boundary layer.
Evaluation of Changes in Dry and Wet Precipitation Extremes in Warmer Climates Using a Passive Water Vapor Modeling Approach
Authors: Labonté Marie-Pier , Merlis Timothy M. 
Published: December 2022

Abstract
Hydroclimatic extremes, such as heavy daily rainfall and dry spells, are expected to intensify under anthropogenic warming. Often, these changes are diagnostically related to thermodynamic increases in humidity with warming. Here, we develop a framework that uses an online calculation of the thermodynamically induced changes of the full precipitation distribution with warming in an idealized moist atmospheric general circulation model. Two water vapor variables, the standard active one and an additional passive one (i.e., no latent heat release when condensation occurs), are advected by the resolved circulation. The passive water vapor is thermodynamically perturbed by modifying the saturation specific humidity used in the calculation of its condensation tendency and surface evaporation. The difference between the precipitation of the perturbed passive water vapor relative to the control one corresponds to the thermodynamic component of precipitation change, which can be evaluated for the entire distribution. Here, we evaluate wet and dry extremes. Our simulations have tropical increases and higher-latitude decreases of dry spell’s length (defined as the maximum consecutive dry days), as found in the zonal mean of comprehensive models. This simulated thermodynamically induced intensification of dry spells in the tropics arises from the decreased contrast between sea surface temperature and surface air temperature with warming. There is a simulated increase in heavy daily rainfall (e.g., the 99.9th percentile of the daily precipitation distribution) at all latitudes that differ modestly from a previous theory that assumes moist-adiabatic stratification. Consistent with this theory, increased warming aloft slightly dampens the simulated increase.
Should moderate ischemic mitral regurgitation be corrected during coronary artery bypass grafting? a systematic review and meta‐analysis
Authors: Wu Haibo , Zhang Wei 
Published: December 2022

Objective Ischemic mitral regurgitation (IMR) is associated with increased risks of mortality and heart failure. However, the optimal management of moderate IMR remains controversial. We conducted a meta-analysis to appraise whether moderate IMR should be corrected during coronary artery bypass grafting (CABG). Methods We searched PubMed, Embase, and Cochrane databases from its inception up to 15 October 2022 for studies that assessed CABG alone versus CABG with mitral valve (MV) surgery in patients with moderate IMR. The primary outcome was perioperative mortality. Results Four randomized controlled trials and three observational studies with propensity-matched data including 1209 patients assessing CABG alone ( n = 598) versus CABG with MV surgery ( n = 611) were included. Compared to CABG alone, the addition of MV surgery did not significantly increase perioperative mortality (RR, 1.01; 95% CI, 0.52–1.96; p = 0.98) and stroke (RR, 2.14; 95% CI, 0.97–4.72; p = 0.06), whereas a longer cardiopulmonary bypass duration (MD, 54.91; 95% CI, 42.13–67.68; p < 0.01) and an increased incidence of renal failure were observed in the combined-procedure group. At follow-up, the addition of MV surgery was significantly associated with reduced rates of residual MR (RR, 0.26; 95% CI, 0.13–0.51; p < 0.01) and NYHA class III-IV (RR, 0.54; 95% CI, 0.37–0.78; p < 0.01). However, there was no difference in either mid-term mortality (RR, 1.05; 95% CI, 0.65–1.70; p = 0.82) or late mortality (RR, 91; 95% CI, 0.49–1.71; p = 0.78) between the CABG alone group and the combined-procedure group. Conclusions In patients with moderate IMR, the addition of MV surgery to CABG did not increase perioperative mortality. Despite the reduced rates of moderate MR and NYHA class III-IV at follow-up, the addition of MV surgery did not translate in a reduction in mid-term or late mortality.
A thematic analysis of hospital medical records of patients with advanced illness experiencing incarceration in the last 3 months of life
Authors: Le Gautier Roslyn , Panozzo Stacey , Bryan Tamsin , Lethborg Carrie , Philip Jennifer 
Published: December 2022

Background: The constraining prison culture is not, for the most part, conducive to the provision of palliative care for people in prison. Aim: This study aimed to explore patterns of palliative and end-of-life care provision for hospitalised prison patients. Design: A retrospective qualitative review of hospital medical records to explore the quality of end-of-life care provision for patients experiencing incarceration who died within hospital. Qualitative inductive analysis of record extracts of each patients final 3-months of life was undertaken. Setting/participants: An Australian metropolitan hospital responsible for providing secondary and tertiary health services for people experiencing incarceration. This study included a systematic sample of male patients experiencing incarceration who died in hospital between 2009 and 2019. Results: Medical record extracts of 15 male patients revealed two broad themes: (1) barriers to equitable access to palliative care for incarcerated hospitalised patients; and (2) factors that facilitated quality end-of-life care for patients and families. Barriers included: tensions between balancing risk and humanity; and limited agency over place and death. Conversely, early recognition of deterioration and anticipated dying provided patients and families opportunity to focus on end-of-life goals. Conclusions: Institutional influences of security and control challenged the provision of equitable end-of-life care for people experiencing incarceration. Further research is required to inform, and incorporate, best approaches to identifying patient wishes and advance planning into care within, or despite, the constrains of incarceration. Policy reform and a coordinated, best practice approach to the management of end-of-life care for people experiencing incarceration is needed.
Intra- and interobserver agreement of rectal cancer staging with MRI
Authors: Kilickap Gulsum , Dolek Betul Akdal , Ercan Karabekir 
Published: December 2022

Background Reliable preoperative staging of rectal cancers is crucial for treatment decision making. Purpose To assess the intra- and inter-observer agreement of rectal cancer staging, including the sub-categories, with magnetic resonance imaging (MRI). Material and Methods The study includes 85 patients (35.3% women; mean age = 62.2 ± 11.2 years) who underwent MRI for rectal cancer staging between August 2020 and April 2021. All the stored images were evaluated independently by two radiologists with 10–15 years of experience. For intra-observer agreement, the evaluations were done two months apart. Analyses were made using kappa, prevalence and bias-adjusted kappa (PABAK), and intraclass correlation coefficient (ICC), where appropriate. Results There was a substantial inter-observer agreement for tumor localization (kappa = 0.665, PABAK = 0.682), mesorectal fascia invasion (kappa = 0.663, PABAK = 0.822), internal and external sphincter involvement (kappa 0.804 and 0.751, PABAK 0.859 and 0.929, respectively), and moderate to substantial agreement for M-staging (kappa = 0.451, PABAK = 0.742) and extramural vascular invasion (kappa = 0.569, PABAK = 0.741). There was also a good inter-observer agreement for T staging and N staging (ICC = 0.862, 95% confidence interval [CI] = 0.788–0.911; and ICC = 0.841, 95% CI = 0.595–0.922, respectively). As expected, intra-observer agreement was better than inter-observer agreement. Conclusion Intra- and inter-observer agreement for MRI staging of rectal cancers using the structured reporting template is good.
Clinical Profile of COVID-19 Positive Neonates in a Tertiary Care Hospital
Authors: Munian Dinesh , Mukherjee Subhayan , Roy Oishik , Zaman Asraf Uz , Singh Rajesh Kumar 
Published: December 2022

Objective: To evaluate clinical profiles of COVID-19 neonates and compare early onset (<7 days) vs late onset (≥7 days) COVID. Methods: Prospective observational study conducted among the neonates who were at risk or COVID-19 positive and who were admitted consecutively in one year (from June 2020 to May 2021) to evaluate their clinical status. At risk neonates underwent RT-PCR for oropharyngeal swab within 24 to 48 hours of life (inborn) or after admission (outborn). Results: Out of 351 at risk neonates, 106 babies came positive (early = 35.4% and late = 64.6%). Twelve (11.3%) cases were positive within 24 to 48 hours of life, indicating perinatal transmission. A total of 62 (58.4%) positive newborns were symptomatic. In their clinical course, there was Respiratory distress in 33(31.1%), diarrhoea in 7 (6.6%), poor feeding or lethargy in 24 (23.1%), fever in 19 (17.9 %) neonates. One baby developed COVID MIS-N. Early onset group was more symptomatic ( P value <.05) but late onset group had a longer hospital stay (Spearman’s rho <0.5) and increased duration of oxygen requirement ( t-test sig. [2-tailed] < 0.05). Conclusion: There is high incidence of perinatal transmission. Early onset group was more symptomatic but late onset group had increased duration of oxygen requirement and longer hospital stay.
Root Curvature in Non-Syndromic Oral Clefts: A Case-Control Study in a Brazilian Population
Authors: Lopes Gabriela dos Santos , Guimarães Laís , Nascimento Eduarda , Freitas Deborah Q. , Rebello Iêda , Medrado Alena P. , Coletta Ricardo D. , Reis Silvia R. A. 
Published: December 2022

Objective This study assesses the degree of root curvature in patients with non-syndromic cleft lip and/or palate (NSCL/P). Design Retrospective. Case-control study. Setting Root curvature was assessed in lower premolars and molars in 800 panoramic radiographs: 400 from patients with cleft and 400 from healthy control individuals. Root curvature was classified according to its angulation, as well as its apical, medial, or coronal localization. Results The frequency of mild curvature in the NSCL/P group compared to the control group was higher in premolars especially in the left second premolar in cleft palate (OR: 6.91; 95% CI: 3.23−14.77; P < .0001). The frequency of moderate curvature in molars was significantly higher in the cleft group, with the highest risk in the right first molar in the cleft lip group (OR: 2.74; 95% CI: 1.67−4.52; P < .0001). Inclination was more frequently observed in the apical third of the root in the group with cleft, whereas for the control group, the curvature was more frequent in the medial third. In patients with cleft, the OR of curvature in the apical third was significant in premolars (left lower second premolar: Cleft lip, OR: 1.91; 95% CI: 1.04−3.52; P = .03; right lower second premolar: Cleft lip, OR: 1.91, 95% CI: 1.04−3.50; P = .03, cleft lip and palate, OR: 1.75; 95% CI: 1.12−2.73; P = .01). Conclusion The results of the current study indicate differences in root curvature in patients with non-syndromic cleft lip and/or palate, which should be considered during the dental treatment planning of patients.