bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adherence and persistence to pharmacotherapy in patients with heart failure: a nationwide cohort study, 2014–2020
Authors: Ødegaard Kristina Malene , Lirhus Sandre Svatun , Melberg Hans Olav , Hallén Jonas , Halvorsen Sigrun 
Published: October 2022

AbstractAimsWe aimed to study initiation, adherence, and long‐term persistence to beta‐blockers (BB), renin–angiotensin system inhibitors (RASi), and mineralocorticoid receptor antagonists (MRA) in a nationwide cohort of patients with heart failure (HF).MethodsPatients aged 18–80 years in Norway with a first diagnosis of HF from 2014 until 2020 that survived ≥30 days were identified from the Norwegian Patient Registry and linked to the Norwegian Prescription Database. We collected information about BB, RASi [angiotensin‐converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARB), and angiotensin receptor‐neprilysin inhibitors (ARNI)], and MRA. Dual HF therapy was defined as taking at least two out of three drug classes, whereas triple HF therapy was defined as taking all three. Initiation (time to initiation) and persistence (time to discontinuation using a grace period of 30 days) of HF drugs was calculated by the Kaplan–Meier method, followed to outcome of interest, death, or December 2020. One‐year adherence was measured as proportion of days covered (PDC) using a cut‐off at 80%. For adherence and persistence measurements, we allowed for maximum 60 days of stockpiling and switching within drug groups. We performed sensitivity analyses to test the robustness of our findings.ResultsOut of 54 899 patients included in the cohort, 75%, 69%, and 21% initiated a BB, RASi, and MRA, respectively, whereas 13% did not receive any. Dual and triple HF therapy was prescribed to 61% and 16%, respectively. The proportion of adherent patients during the first year following initiation was 83%, 81%, 84%, and 61% for BB, RASi, ARNI, and MRA, whereas 42% and 5% were adherent to dual and triple HF therapy, respectively. From 2 to 5 years following initiation, persistence decreased from 58% to 38%, 57% to 37%, and 31% to 15% for BB, RASi, and MRA, respectively. Within the RASi group, persistence was higher for ARNI than for ACEI and ARB. There were no major changes in either initiation or adherence of the drug classes from 2014 to 2019, except for an increase in initiation and adherence of MRA.ConclusionsWe found low adherence to dual and triple HF therapies in this nationwide cohort study of newly diagnosed HF patients. Efforts are needed to increase adherence and persistence to HF therapies into clinical practice, emphasizing maintenance of multiple drug therapies in patients with such an indication.
Recent Advances in the Chemistry of Iminoborane Derivatives
Authors: Fan Yonghao , Cui Jingjing , Kong Lingbing 
Published: October 2022

AbstractIminoboranes are important unsaturated organoboron compounds with the formula RB≡NR’. They are isoelectronic with alkynes, yet normally exhibit higher reactivity due to their polarity, thus enabling versatile applications in coordination, synthetic and materials chemistry. This review briefly describes the most recent progress in iminoborane derivatives with the focus on new persistent species and their diverse reactivity, which greatly enrich the iminoborane chemistry. In addition, the promising research directions are also provided.
Synthesis of 3‐Arylacetamides Substituted Maleimide Via Weakly Coordinating Acetamide Assisted Cross‐dehydrogenative Coupling and Their Photophysical Studies
Authors: Mishra Saksham , Kumar Amit 
Published: October 2022

AbstractMaleimides serve as an important synthetic precursor for various organic transformation reactions. However, maleimides have been rarely employed as coupling partners for the direct synthesis of 3‐aryl substituted maleimides via oxidative Heck‐type reaction, due to the lack of β‐hydrogen at the syn‐periplanar position. Therefore, herein, we report an efficient and highly selective synthesis of 3‐arylacetamide incorporated maleimides through the cross‐dehydrogenative coupling process using the simple and native primary acetamide as a weakly directing group with Pd(II)‐catalysis conditions. This reaction furnishes 3‐arylated maleimide derivatives in good yields with high functional group tolerance. Furthermore, 3‐arylated maleimides were transformed into synthetically important derivatives. Based on preliminary control experiments, a probable reaction mechanism has been proposed for the distal C−H bond functionalization reaction. Interesting photophysical properties of the synthesized products were also observed.
Hydroxyl‐Directed Iridium‐Catalyzed Synthesis of Pyrano[2,3,4‐de]chromen‐2‐ones and Further Chalcogenation under Blue‐Light Irradiation
Authors: Yan Kelu , Wang Xiaoyu , Wen Jiangwei , Li Qiuyun , Zhang Ning , Zhu Shuyun , Zhao Xian‐En , Wang Xiu 
Published: October 2022

AbstractThe hydroxyl‐directed iridium‐catalyzed peri‐selective C−H bond activation to synthesize substituted pyrano[2,3,4‐de]chromen‐2‐ones and further chalcogenylation under blue light irradiation has been realized efficiently. Most products of polycyclic pyrans and corresponding chalcogenated derivatives with various substituents were achieved in good to excellent yields. Preliminary mechanistic studies suggest that this transformation may pass through a five‐membered iridacycle intermediate containing an O−Ir σ‐bond and a photocatalytic free radical process.
Principles of LGBTQ+ Evaluation
Authors: Phillips Gregory , Felt Dylan , Perez‐Bill Esrea , Ruprecht Megan M. , Elías Glenn Erik 
Published: October 2022

AbstractThe time is long overdue for the field of evaluation to critically reckon with how we have failed to appropriately consider the needs and experiences of lesbian, gay, bisexual, transgender, queer, and other sexual and gender minority (LGBTQ+) people. Perhaps even more importantly, there is a dire need for work that moves us forward in new directions which are more affirming and inclusive of LGBTQ+ people. To achieve this idealistic change in LGBTQ+ Evaluation will require a genuine, transformative paradigm shift within the evaluation field, encompassing everything from pedagogy to practice and all activities in between. As a first step toward a unified paradigm of LGBTQ+ Evaluation, this chapter proposes eight Principles of LGBTQ+ Evaluation to guide evaluators’ work in partnership with and in service of LGBTQ+ communities, organizations, and individuals. Here we are not seeking to provide a script or a rigid framework but rather to create guiding signposts that light the way for evaluators new to LGBTQ+ Evaluation.
An assessment of the dietary habits among road cyclists competing in amateur races
Authors: Matusiak‐Wieczorek Ewelina , Pyciarz Lidia , Drobniewski Marek , Borowski Andrzej 
Published: October 2022

AbstractFrom year to year, practicing various sports by amateur athletes is becoming more and more popular. One of such sports is road cycling. To achieve very good sports performance athletes should pay attention not only to physical activity but also to proper nutrition and hydration of the body. The aim of the study was to assess amateur cyclists' dietary habits, especially nutrition and hydration, including assessment of the regularity of eating meals, type of consuming products and fluid intake preferences. The study recruited 41 men aged 23–75 years (43.76 ± 13.25) participating in amateur race road cycling. To obtain information about nutrition and hydration, an original questionnaire was used. Out of all participants, 65.9% declared that they pay attention to their diet, and as many as 75.6% indicated that they eat meals regularly. The vast majority (43.9%) of the cyclists declared consuming four meals a day. Most of the cyclists consumed meat products several times a week—73.2% and dairy products—43.9%. The participants most often chose only one portion of fruit (41.5%) and vegetables (31.7%) during the day. The vast majority of cyclists consumed 3 L of fluids on a training day—51.2%. It turned out that all of the athletes hydrated during training: before it was 68.3% and after training—92.7%. We conclude that the amateur cyclists pay a lot of attention to their nutrition and hydration. During the day, most athletes eat an appropriate amount of meals on a regular basis and drink the right amount of fluids. However, eating of dairy, fruits and vegetables, or hydrating before exercising is insufficient.
Exploring the socio‐political dynamics of front‐line managers’ HR involvement: A qualitative approach
Authors: Kurdi‐Nakra Hussein , Pak Jongwook 
Published: October 2022

AbstractMoving beyond the extant HR implementation research that has often viewed the implementation decisions primarily as front‐line managers' (FLMs) prerogative, this article explores interactive processes involving three key actors: HR managers, senior managers, and FLMs. Drawing on a political lens, the authors find that the way in which FLMs enact HR practices depends on the relative power of the enforcing actors (i.e., HR managers) and the endorsing actors (i.e., senior managers). The study findings reveal that while the enforcers employ a range of influence tactics (e.g., legitimization, pressure, rational persuasion, and consultation) to facilitate strict HR enactment, the endorsers use counter‐influence tactics (e.g., legitimization, assertiveness, and inspirational appeal) in support of deviant HR implementation behaviors. Carefully navigating both sides' influence tactics in light of past involvement experiences, FLMs choose subsequent implementation behaviors accordingly. The paper makes a meaningful contribution to the HR devolution research by delving into relational power dynamics that develop over an early phase of HR implementation. The resulting theoretical framework provides novel insights into the reasons behind FLMs' divergent forms of implementation behaviors. It shows that the ongoing multi‐lateral interactions and political maneuverings involving HR‐related actors trigger distinct HR involvement patterns.
Postdiagnosis body fatness, recreational physical activity, dietary factors and breast cancer prognosis: Global Cancer Update Programme (CUP Global) summary of evidence grading
Authors: Tsilidis Konstantinos K. , Cariolou Margarita , Becerra‐Tomás Nerea , Balducci Katia , Vieira Rita , Abar Leila , Aune Dagfinn , Markozannes Georgios , Nanu Neesha , Greenwood Darren C. , Giovannucci Edward L. , Gunter Marc J. , Jackson Alan A. , Kampman Ellen , Lund Vivien , Allen Kate , Brockton Nigel T. , Croker Helen , Katsikioti Daphne , McGinley‐Gieser Deirdre , Mitrou Panagiota , Wiseman Martin , Cross Amanda J. , Riboli Elio , Clinton Steven K. , McTiernan Anne , Norat Teresa , Chan Doris S. M. 
Published: October 2022

AbstractBased on the Global Cancer Update Programme, formally known as the World Cancer Research Fund/American Institute for Cancer Research Continuous Update Project, we performed systematic reviews and meta‐analyses to investigate the association of postdiagnosis body fatness, physical activity and dietary factors with breast cancer prognosis. We searched PubMed and Embase for randomised controlled trials and longitudinal observational studies from inception to 31 October 2021. We calculated summary relative risks (RRs) and 95% confidence intervals (CIs) using random‐effects meta‐analyses. An independent Expert Panel graded the quality of evidence according to predefined criteria. The evidence on postdiagnosis body fatness and higher all‐cause mortality (RR per 5 kg/m2 in body mass index: 1.07, 95% CI: 1.05‐1.10), breast cancer‐specific mortality (RR: 1.10, 95% CI: 1.06‐1.14) and second primary breast cancer (RR: 1.14, 95% CI: 1.04‐1.26) was graded as strong (likelihood of causality: probable). The evidence for body fatness and breast cancer recurrence and other nonbreast cancer‐related mortality was graded as limited (likelihood of causality: limited‐suggestive). The evidence on recreational physical activity and lower risk of all‐cause (RR per 10 metabolic equivalent of task‐hour/week: 0.85, 95% CI: 0.78‐0.92) and breast cancer‐specific mortality (RR: 0.86, 95% CI: 0.77‐0.96) was judged as limited‐suggestive. Data on dietary factors was limited, and no conclusions could be reached except for healthy dietary patterns, isoflavone and dietary fibre intake and serum 25(OH)D concentrations that were graded with limited‐suggestive evidence for lower risk of the examined outcomes. Our results encourage the development of lifestyle recommendations for breast cancer patients to avoid obesity and be physically active.
Analysis of phenotype and gene mutation in three pedigrees with inherited antithrombin deficiency
Authors: Li Min , Jiang Shuting , Liu Siqi , Jin Yanhui , Wang Mingshan 
Published: October 2022

AbstractBackgroundInherited AT deficiency is an autosomal‐dominant thrombophilic disorder usually caused by various SERPINC1 defects associated with a high risk of recurrent venous thromboembolism. In this article, the phenotype, gene mutation, and molecular pathogenic mechanisms were determined in three pedigrees with inherited AT deficiency.MethodsCoagulation indices were examined on STAGO STA‐R‐MAX analyzer. The AT:Ag was analyzed by ELISA. All exons and flanking sequences of SERPINC1 were amplified by PCR. AT wild type and three mutant expression plasmids were constructed and then transfected into HEK293FT cells. The expression level of AT protein was analyzed by ELISA and Western blot.ResultsThe AT:A and AT:Ag of probands 1 and 3 were decreased to 49% and 52 mg/dL, 38% and 44 mg/dL, respectively. The AT:A of proband 2 was decreased to 32%. The SERPINC1 gene analysis indicated that there was a p.Ile421Thr in proband 1, a p.Leu417Gln in proband 2, and a p.Met252Thr in proband 3, respectively. The AT mRNA expression level of the three mutants was not significantly different from AT‐WT by qRT‐PCR. The results of ELISA and Western blot tests showed that the AT‐M252T and AT‐I421T mutants had a higher AT expression than the AT wild type (AT‐WT), and the AT protein expression of AT‐L417Q mutants had no significant difference compared with AT‐WT in the cell lysate. The AT expression levels of AT‐M252T and AT‐I421T mutants were lower than that of AT‐WT, and there was no significant difference between AT‐L417Q mutant and AT‐WT in the supernatant.ConclusionThe p.I421T and p.M252T mutations affected the secretion of AT protein leading to type I AT deficiency of probands 1 and 3. The p.Leu417Gln mutation was responsible for the impaired or ineffective activity AT protein in proband 2 and caused type II AT deficiency.
Bortezomib‐based therapy is effective and well tolerated in frontline and multiply pre‐treated Waldenström macroglobulinaemia including BTKi failures: A real‐world analysis
Authors: Khwaja Jahanzaib , Uppal Encarl , Baker Robert , Trivedi Kajal , Rismani Ali , Gupta Rajeev , Proctor Ian , Kyriakou Charalampia , D'Sa Shirley 
Published: October 2022

AbstractWaldenström macroglobulinemia (WM) is a rare, incurable low grade lymphoma following a relapsing trajectory. Management strategies have evolved with the introduction of targeted therapy including new classes of Bruton tyrosine kinase inhibitor (BTKi). Treatment may however be limited particularly at relapse by a lack of drug availability and tolerability. We assessed the real‐world efficacy and tolerability of bortezomib‐containing regimens in patients with WM at frontline and relapse including those with prior BTKi resistance. Forty‐one patients were identified with 44 bortezomib‐containing regimens administered (n = 12 frontline, n = 32 relapse). Of patients treated at relapse, the median prior lines of therapy was 3 (range 1–7). 24% (10/41) of the cohort were refractory or intolerant to BTKi prior to bortezomib delivery. The median follow‐up after bortezomib administration was 34 months (range 0‐131). Overall response rate was 88%; 2‐year overall survival and progression‐free survival were 90% (95% confidence interval [CI] 73–96) and 76% (95% CI 55–87), respectively. Median time‐to‐next‐treatment was 66 months. Neuropathy (grade 1–2) occurred in 24% (8/34) and did not result in treatment cessation in any case. Gastrointestinal disturbance occurred in 7% (3/41). Treatment discontinuations were rare (1/44; 2%), suggesting a manageable safety profile. Major response rate was comparable in those with prior BTKi compared with those without (75% [6/8] vs 84% [27/32], p = 0.61). Bortezomib should be considered as a treatment modality particularly in those who are refractory to BTKi.
Perceived legitimacies of health‐related and motivational presenteeism and absenteeism: Development and validation of the Workplace Attendance Behavior Legitimacy Scale
Authors: Ruhle Sascha A. , Breitsohl Heiko 
Published: October 2022

AbstractWorkplace attendance behaviors (WABs), that is, absenteeism and presenteeism, are important to both organizations and individuals. Yet, despite growing knowledge on their formation and ongoing calls for its exploration, research on how the legitimacy of WAB impacts attendance decisions is missing. We contribute by providing researchers with the Workplace Attendance Behavior Legitimacy Scale (WABLS), a reliable, valid, and economical measure validated in English and German, across five samples. WABLS includes 12 items that measure the personal norms of attending work via three dimensions that emerged across Studies 1A, 1B, and 2, namely, the respective legitimacies of working in the state of ill‐health (sickness presenteeism), working despite a lack of motivation (motivational presenteeism), and not working due to a lack of motivation (motivational absenteeism). We find that WABLS exhibits good internal consistency, test–retest reliability, discriminant and criterion‐related validity, and longitudinal and cross‐lingual measurement invariance (Study 3). We discuss theoretical implications for attendance legitimacy as well as opportunities for the future use of WABLS.
Almond okara as a valuable ingredient in biscuit preparation
Authors: De Angelis Davide , Pasqualone Antonella , Squeo Giacomo , Summo Carmine 
Published: October 2022

AbstractBACKGROUNDThe okara is the water‐insoluble residue derived from the production of plant‐based beverages, including almond milk. Information on almond okara is scarce, with no scientific references. In the present study, the almond okara was characterized and used to replace wheat flour at 15%, 25% and 35% for biscuit preparation.RESULTSThe contents of protein, lipid and dietary fiber of almond okara were 140.08, 421.16 and 407.90 g kg−1 dry matter, respectively. The lipid fraction of almond okara showed contents of triacylglycerol oligopolymers and oxidized triacylglycerols of 0.12 and 5.14 g kg−1, respectively, which were significantly lower than the levels observed in the sunflower oil used in the formulation of biscuits. Consequently, the biscuits containing okara showed a content of triacylglycerol oligopolymers lower than that of control biscuits. The texture analysis revealed that the addition of the okara at 25% and 35% caused a significant increase in biscuit hardness and a reduction of the brittleness, compared to the control. The sensory evaluation confirmed these data, highlighting the slight impact of the almond okara on the almond odor, taste and flavor attributes.CONCLUSIONAlmond okara is a valuable by‐product that can be easily used as an ingredient for biscuit preparation, exploiting its fiber, protein and lipid content to improve the nutritional value of food, with a limited impact on the sensory properties. © 2022 Society of Chemical Industry.
Who are the language tourists? A factor‐cluster analysis based on language‐related attitudes, beliefs, and travel outcomes
Authors: Carvalho Inês , Ramires Ana , Bakas Fiona 
Published: October 2022

AbstractResearching language tourism (where language learning is a primary or secondary motivation for the trip) is a growing field of interest as the importance of language within tourism experiences is recognized. Conceptually located at the intersection of cultural, youth, academic, and educational tourism, past research has focused on the analysis of tourists who travel to formally learn a language, missing out on an important number of tourists who travel to learn a language informally. To overcome this gap in research, cluster analysis of a sample of 1014 formal and informal language tourists was undertaken to segment them based on language‐related attitudes, beliefs, and travel outcomes. Four clusters of language tourists were identified, called the Enthusiasts, the Devoted, the Pragmatists, and the Less‐Committed. We propose that two axes are fundamental for characterizing and understanding language tourists, thus contributing to expand theory on language tourism.
Biobanked tracheal basal cells retain the capacity to differentiate
Authors: Kelly Natalie A. , Shontz Kimberly M. , Bergman Maxwell , Manning Amy M. , Reynolds Susan D. , Chiang Tendy 
Published: October 2022

AbstractObjectiveWhile airway epithelial biorepositories have established roles in the study of bronchial progenitor stem (basal) cells, the utility of a bank of tracheal basal cells from pediatric patients, who have or are suspected of having an airway disease, has not been established. In vitro study of these cells can enhance options for tracheal restoration, graft design, and disease modeling. Development of a functional epithelium in these settings is a key measure. The aim of this study was the creation a tracheal basal cell biorepository and assessment of recovered cells.MethodsPediatric patients undergoing bronchoscopy were identified and endotracheal brush (N = 29) biopsies were collected. Cells were cultured using the modified conditional reprogramming culture (mCRC) method. Samples producing colonies by day 14 were passaged and cryopreserved. To explore differentiation potential, cells were thawed and differentiated using the air–liquid interface (ALI) method.ResultsNo adverse events were associated with biopsy collection. Of 29 brush biopsies, 16 (55%) were successfully cultured to passage 1/cryopreserved. Samples with higher initial cell yields were more likely to achieve this benchmark. Ten unique donors were then thawed for analysis of differentiation. The average age was 2.2 ± 2.2 years with five donors (50%) having laryngotracheal pathology. Nine donors (90%) demonstrated differentiation capacity at 21 days of culture, as indicated by detection of ciliated cells (ACT+) and mucous cells (MUC5B+).ConclusionPediatric tracheal basal cells can be successfully collected and cryopreserved. Recovered cells retain the ability to differentiate into epithelial cell types in vitro.Level of EvidenceLevel 3.