bluuebunny/crossref_metadata_2025_split huggingface dataset:
Olivine in kimberlites and related rocks – macrocrysts, dunitic nodules and megacrysts from the same metasomatized source
Authors: Arndt Nicholas , Cordier Carole , Boullier Anne-Marie , Batanova Valentina , Magnin Valerie , Findling Nathaniel 
Published: August 2022

Abstract
Kimberlites carry a dense cargo of olivine. Although normally referred to as macrocrysts, much of this olivine is present as multi-grain xenoliths of dunite. Because of their well-rounded outlines, we refer to these objects as ‘nodules’ and apply the term to both multigranular and monogranular varieties. Although compositions within each nodule are very uniform, the entire population displays an enormous variation in Fo content (100*Mg/(Mg + Fe), cation proportions), from close to Fo95 to about Fo82. The change is continuous and there is no indication of separate Fo-rich and Fo-poor populations. Likewise, the sizes, internal textures and habits of Fo-rich and Fo-poor olivines are indistinguishable. Fo-poor nodules have compositions like those of olivines of the megacryst suite and they share similar sizes and internal structures. We propose that the dunite nodules in kimberlites and olivines of the megacryst suite have a common origin. In our interpretation, almost all olivines in kimberlites, except for the marginal rims and rinds, are fragments of dunite that was produced during interaction between mantle peridotite and CO2-rich fluid. Analogues of this process can be found in ophiolites where dunite is the product of reaction between basaltic magma and peridotite. In-situ reactive crystallisation eliminated pyroxene leaving only olivine with Fo contents ranging from higher to lower Fo than in the host peridotite. This interaction occurred near the base of the lithosphere and not during transit of kimberlite towards the surface.
Sentimental Business Cycles
Authors: Lagerborg Andresa , Pappa Evi , Ravn Morten O 
Published: August 2022

Abstract
We estimate the dynamic causal effects of consumer sentiment shocks in the US. We identify autonomous changes in survey evidence on consumer confidence using fatalities in mass shootings as an instrument. We find the instrument to be significant for an aggregate index of consumer expectations and also back up the identification scheme with micro evidence that exploits the geographical variation in mass shootings. Sentiment shocks have real macroeconomic effects. A negative sentiment shock is recessionary: It sets off a persistent decline in consumer confidence and induces a contraction in industrial production, private sector consumption and in the labour market, while having less evident nominal effects. Finally, sentiment shocks explain a non-negligible part of the cyclical fluctuations in consumer confidence and real macroeconomic aggregates.
16Science and Medicine
Authors: Ramos Adela , Spratt Danielle 
Published: August 2022

Abstract
This review considers three monographs that use innovative archival recovery techniques to expand our understanding of the connections between the history of science and medicine and sociopolitical and cultural phenomena across the early modern period to the present. Divided into three sections, our review first considers Kalle Kananoja’s Healing Knowledge in Atlantic Africa: Medical Encounters, 1500–1850, which demonstrates the ways that Atlantic African healers resisted colonial influence and adapted their practices to reflect innovative uses of global plant-based medicines. Part 2 of this review, Black Reproductive Health, examines Sara Clarke Kaplan’s The Black Reproductive: Unfree Labor and Insurgent Motherhood, which, importantly, revises longstanding assumptions about the ways that we understand and document reproductive health and justice, especially in the American Black community. Part 3, ‘Healthy’ Eating, discusses Elizabeth A. Williams’s Appetite and Its Discontents: Science, Medicine, and the Urge to Eat, 1750–1950, which deconstructs the so-called connection between appetite and wellness in science and medicine. We have chosen to focus on these works both for the important new insights that they offer to the field of the history of science and because they each speak to contemporary crises in public health and health inequity that continue to affect our local and global landscapes. We suggest that works such as these have the capacity not only to expand our field but also to counteract narratives of white supremacy and other cultural beliefs that stigmatize and oppress; these works show us how expanding our understanding of the origins and current practices of medical knowledge beyond our traditional Western narratives can help provide healthier and more equitable forms of care and wellness.
LncRNA‐412.25 activates the LIF/STAT3 signaling pathway in ovarian granulosa cells of Hu sheep by sponging miR‐346
Authors: Yao Xiaolei , El‐Samahy Mohamed AbdFatah , Li Xiaodan , Bao Yongjin , Guo Jiahe , Yang Fan , Wang Zhibo , Li Kang , Zhang Yanli , Wang Feng 
Published: August 2022

AbstractAlthough long non‐coding RNAs (lncRNAs) are reported to regulate follicular development and reproductive disease pathogenesis, the underlying mechanisms have not been elucidated. In this study, lncRNA expression profiling of different‐sized healthy follicles from Hu sheep with different prolificacy revealed 50 613 lncRNAs. Numerous lncRNAs were differentially expressed among different comparison groups. This study characterized one novel transcript, lncRNA‐412.25 (from healthy follicles with a diameter of >5 mm), which was predominantly expressed in the high prolificacy group and localized to the cytoplasm of granulosa cells (GCs). LncRNA‐412.25 knockdown promoted and inhibited Hu sheep GC apoptosis and proliferation, respectively. Interestingly, lncRNA‐412.25 could directly bind to miR‐346, which can target the gene of leukemia inhibitory factor (LIF). Knockdown of lncRNA‐412.25 promoted GC apoptosis by downregulating LIF expression, where this effect was attenuated by miR‐346. Moreover, the miR‐346 inhibitor mitigated the lncRNA‐412.25 knockdown‐induced downregulation of phosphorylated protein of signal transducer and activator of transcription 3 (STAT3), which was validated using immunofluorescence analysis. Our results demonstrated that lncRNA‐412.25 regulates GC proliferation and apoptosis in Hu sheep by binding to miR‐346 and then activating the LIF/STAT3 pathway. These findings provide novel insights into the mechanisms underlying prolificacy in sheep.
Preoperative Ultrasound-guided Percutaneous Cryoneurolysis for the Treatment of Pain after Mastectomy: A Randomized, Participant- and Observer-masked, Sham-controlled Study
Authors: Ilfeld Brian M. , Finneran John J. , Swisher Matthew W. , Said Engy T. , Gabriel Rodney A. , Sztain Jacklynn F. , Khatibi Bahareh , Armani Ava , Trescot Andrea , Donohue Michael C. , Schaar Adam , Wallace Anne M. 
Published: August 2022

Background
Ultrasound-guided percutaneous cryoneurolysis is an analgesic technique in which a percutaneous probe is used to reversibly ablate a peripheral nerve(s) using exceptionally low temperature, and has yet to be evaluated with randomized, controlled trials. Pain after mastectomy can be difficult to treat, and the authors hypothesized that the severity of surgically related pain would be lower on postoperative day 2 with the addition of cryoanalgesia compared with patients receiving solely standard-of-care treatment.

Methods
Preoperatively, participants at one enrolling center received a single injection of ropivacaine, 0.5%, paravertebral nerve block at T3 or T4, and perineural catheter. Participants subsequently underwent an active or sham ultrasound–guided percutaneous cryoneurolysis procedure of the ipsilateral T2 to T5 intercostal nerves in a randomized, patient- and observer-masked fashion. Participants all received a continuous paravertebral block with ropivacaine, 0.2%, until the early morning of discharge (usually postoperative day 2). The primary endpoint was the average pain level measured using a 0 to 10 numeric rating scale the afternoon of postoperative day 2. Participants were followed for 1 yr.

Results
On postoperative day 2, participants who had received active cryoneurolysis (n = 31) had a median [interquartile range] pain score of 0 [0 to 1.4] versus 3.0 [2.0 to 5.0] in patients given sham (n = 29): difference –2.5 (97.5% CI, –3.5 to –1.5), P < 0.001. There was evidence of superior analgesia through month 12. During the first 3 weeks, cryoneurolysis lowered cumulative opioid use by 98%, with the active group using 1.5 [0 to 14] mg of oxycodone compared with 72 [20 to 120] mg in the sham group (P < 0.001). No oral analgesics were required by any patient between months 1 and 12. After 1 yr chronic pain had developed in 1 (3%) active compared with 5 (17%) sham participants (P < 0.001).

Conclusions
Percutaneous cryoneurolysis markedly improved analgesia without systemic side effects or complications after mastectomy.

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What This Article Tells Us That Is New
Skin Biopsy in Pediatric Oncology/Hematopoietic Stem Cell Transplantation Patients
Authors: Bui Justin , Harvey Nathan T. , Berry Bligh , Chan Jonathan , Ramachandran Shanti , Gough Hazel , Wood Benjamin A. 
Published: August 2022

Abstract:The aim of this study was to review the dermatopathological findings in skin biopsy specimens from pediatric oncology and hematopoietic stem cell transplantation patients over a 20-year period. Three hundred fifty-two skin biopsies from 240 patients were reviewed, and the findings were grouped into 6 categories: index neoplasms, nonindex neoplasms, infections, graft-versus-host disease, other treatment complications, and others. Among the index neoplasms identified on skin biopsy, the most common conditions were Langerhans cell histiocytosis (14 patients) and melanoma (7 patients), with other hematological malignancies and an array of soft-tissue tumors accounting for the bulk of the remainder. Neoplastic conditions common in general dermatopathological practice such as basal cell carcinoma and squamous cell carcinoma were uncommon, each being identified in only 1 patient younger than the age of 18, although basal cell carcinomas developing subsequently in young adult life were identified in 7 patients. Infections were common, with infectious agents or viral cytopathic effects (not including human papillomavirus) identified in 34 biopsies. A significant proportion (74%) represented invasive fungal infections, which are of very significant clinical importance. Biopsies performed for a clinical suspicion of graft-versus-host seldom showed histological features to suggest an alternative diagnosis, with only a single case suggesting a diagnosis of toxic erythema of chemotherapy identified.
Enfortumab Vedotin–Associated Toxic Epidermal Necrolysis-like Toxic Erythema of Chemotherapy
Authors: Birmingham Suzanne W. , Moon Deborah J. , Kraus Christina N. , Lee Bonnie A. 
Published: August 2022

Abstract:
Enfortumab vedotin is an antibody–drug conjugate used for treatment of urothelial cancer. It has recently been associated with several reports of Stevens Johnson syndrome/toxic epidermal necrolysis (TEN). In this report, we describe the case of a 63-year-old man who developed widespread, near full–thickness desquamation, clinically mimicking TEN but with histologic features of toxic erythema of chemotherapy. This distinction is significant because it may have implications for prognosis and treatment. Further investigation is needed to ascertain the incidence of true TEN versus clinical imitators in patients with enfortumab vedotin–related cutaneous toxicity.
Sweat Gland Carcinoma With Neuroendocrine Differentiation of the Areola as a Potential Clinicopathologic Mimicker of Male Breast Carcinoma and Syringocystadenocarcinoma Papilliferum
Authors: Bun Shota , Goto Keisuke , Oishi Takuma , Kiyohara Yoshio , Tsutsumida Arata , Yoshikawa Shusuke 
Published: August 2022

Abstract:
Sweat gland carcinoma with neuroendocrine differentiation (SCAND) is a newly proposed tumor entity of primary cutaneous apocrine/eccrine adnexal tumor with neuroendocrine differentiation. The histopathologic variations are not yet well known. In this article, we present a case of SCAND mimicking male breast cancer and syringocystadenocarcinoma papilliferum. A 68-year-old man presented with a reddish 12-mm nodule on his left areola. No lymph node or distant metastases were observed. The patient was disease free 1 year and 9 months after the tumor was surgically resected but died of cerebral hemorrhage. Histopathological examination revealed a predominantly intradermal tumor with marked syringotropism, mimicking a component of mammary ductal carcinoma in situ. In addition, another tissue section displayed a cup-shaped papillated tumor with syringocystadenocarcinoma papilliferum–like features, which were also seen because of marked syringotropism. Diffuse immunoexpression of cytokeratin 7, cytokeratin 19, chromogranin A, synaptophysin, INSM1, estrogen receptor, carcinoembryonic antigen, epithelial membrane antigen, and GATA3 was observed in the tumor, but no BRAF immunoexpression was seen. The present case would help us to understand the histopathological variation and differential diagnosis of SCAND. The histopathological diagnosis of male breast cancer or syringocystadenocarcinoma papilliferum should be made by ruling out SCAND.
Major Histotypes in Skin Melanoma: Nodular and Acral Lentiginous Melanomas Are Poor Prognostic Factors for Relapse and Survival
Authors: Tas Faruk , Erturk Kayhan 
Published: August 2022

Abstract:
The histological subtype is not considered one of the major prognostic factors in melanoma, yet it is known to have an impact on survival. The aim of this study was to investigate the clinical significance of histological subtypes and the possible impacts of clinicopathological factors on the course of melanoma patients of all stages. A total of 1017 cutaneous melanoma patients were analyzed retrospectively. Four major melanoma histotypes that were studied in this study were as follows: (1) superficial spreading melanoma (SSM), (2) nodular melanoma (NM), (3) acral lentiginous melanoma (ALM), and (4) lentigo maligna melanoma (LMM). Unlike SSMs and LMMs, there were statistically significant correlations between NMs and ALMs and most aggressive histopathological prognostic indicators, such as higher Clark level (P = 0.0001), thick Breslow depth (P = 0.0001), presence of ulceration (P = 0.0001), and lymphovascular invasion (P = 0.0001). Furthermore, NMs and ALMs were also associated with advanced clinical stages, that is, node involvement and metastasis. Relapse rates for nonmetastatic melanomas were higher in NMs (39.6%) and ALMs (35.3%) than in SSMs (24.3%) and LMMs (10.3%) (P = 0.0001). Additionally, 5-year relapse-free survival rates were 90.5%, 70.5%, 55.7%, and 50.5% in LMMs, SSMs, ALMs, and NMs, respectively (P = 0.0001). Moreover, 5-year overall survival rates plummeted from 84.3% in LMMs to 74.8%, 64.3%, and 46% in SSMs, ALMs, and NMs, respectively (P = 0.0001). In conclusion, we observed that the histologic subtype was an independent predictor for relapse and outcome for cutaneous melanoma patients. Both NM and ALM had unfavorable prognoses, and they were associated with known poor pathological and clinical indicators.
Impact of a Powered Prosthetic Ankle-Foot Component on Musculoskeletal Pain in Individuals with Transtibial Amputation: A Real-World Cross-Sectional Study with Concurrent and Recalled Pain and Functional Ratings
Authors: Cacciola Cory E. , Kannenberg Andreas , Hibler Karl D. , Howell Jared 
Published: August 2022

ABSTRACT

Introduction
Traditionally, lower-limb prostheses are composed of passive components, which provide a fraction of the push-off power of the natural ankle-foot complex. In individuals with transtibial amputation (TTA), this leads to deviations and compensatory mechanisms. Studies have reported significant unloading of the sound limb and knee joint with a powered prosthetic ankle-foot. However, despite the promising biomechanical evidence on unloading, no study has yet investigated the impact of powered prosthetic ankle-foot on musculoskeletal pain.

Methods
A total of 250 individuals fit with a powered prosthetic ankle-foot component were invited to participate in an institutional review board–approved cross-sectional study. Participants completed a survey, which collected typical prosthetic history information as well as Numerical Pain Rating Scales across different body regions, the Socket Comfort Score (SCS), the Activity of Daily Living domain of the Knee Injury and Osteoarthritis Outcome Score (KOOS-ADL), and the Oswestry Disability Index (ODI) for both their current and past prosthetic ankle-foot. The differences between results across the two ankle-feet were evaluated in subgroups dependent on the user's current foot.

Results
A total of 57 individuals met the inclusion criteria after completion of the online survey. Forty-one subjects (71.9%) identified as current powered ankle-foot users. Sixteen subjects (28.1%) reported to have used a powered ankle-foot in the past but have since abandoned it. The current powered ankle-foot users' group saw no significant difference in SCSs. The current passive foot users reported significantly (P = 0.002) better socket comfort for the prosthesis with the passive foot. The original and recall-adjusted median ratings of pain in the group of 41 current powered ankle-foot users showed significantly less pain in all three body segments. In the group of 41 current powered ankle-foot users, both the original and recall-adjusted KOOS-ADL and ODI scores were significantly better for the powered ankle-foot.

Conclusions
Individuals in active daily life with TTA may experience relief of sound knee, amputated side knee, and low-back pain, as well as pain-related restrictions in activities of daily living function with use of a powered ankle-foot mechanism.

Clinical Relevance
Providing the right patient with a powered ankle-foot has the potential to decrease the individual's pain. The individual may also have fewer pain-related functional restrictions when attempting to achieve activities of daily living.
A systematic review and meta-analysis of anesthesia type on hip fracture post-surgery outcomes
Authors: Leibold Christopher , Falbo Ryan , Gupta Anil , Miller Richard , Pederson John M. , Malpe Manashree 
Published: August 2022

Abstract

Objective:
To compare technical, clinical, and safety outcomes among hip fracture patients treated with procedures supplemented by general anesthesia (GA) or spinal/regional anesthesia (S/R).

Data sources:
We searched for original studies on PubMed, Ovid MEDLINE, Ovid Embase, and Cochrane databases.

Study selection:
Studies that reported clinical outcomes in patients that underwent hip fracture surgery, had available data on type of anesthesia administered, and clinical follow-up data were selected for data extraction.

Data extraction:
The primary outcomes of interest were odds of mortality, including in-hospital, 30-day, 90-day, and 1-year mortality. Various adverse events (AEs) were also compared.

Data synthesis:
Twenty-eight studies met our selection criteria, including 190,394 patients. A total of 107,314 (56.4%) patients were treated with procedures involving GA while 83,080 (43.6%) were treated with procedures involving S/R. There was no difference in 30-day or >1-year mortality rates between the GA and SR groups; however, compared to S/R group, the GA group had a significantly higher odds of in-hospital (P = .004) and 90-day mortality (P = .004). There was no difference in odds of adverse events between the GA and the S/R group.

Conclusions:
Patients administered S/R for hip fracture procedures demonstrate lower risk of in-hospital mortality and 90-day mortality compared to patients administered GA.

Level of evidence:
Therapeutic level III.
Open tibial shaft fracture management in Argentina: an evaluation of treatment standards in diverse resource settings
Authors: MacKechnie Madeline C. , Albright Patrick D. , Garabano Germán , Bidolegui Fernando , Pereira Sebastian , Pesciallo Cesar Angel , Miclau Theodore ,   Argentina Study Group (Corporate Authors)†
Published: August 2022

Abstract

Background:
Argentina is a country with varying access to orthopedic surgical care. The Argentine Association of Trauma and Orthopedics (AATO) “Interior Committee” was developed to address potential regional differences and promote standardization of orthopedic trauma care. The paper assesses the level of national standardization of the management of open tibia fractures across 9 provinces in Argentina.

Methods:
Utilizing a matched-comparison group design, management of these injuries were assessed and compared between 3 groups: an “AATO Exterior Committee” consisting of surgeons that practice in Buenos Aires, and 2 “Interior Committees,” comprising surgeons that practice in outlying provinces, 1 of which is affiliated with the AATO, and 1 that is not affiliated with the AATO. The study was conducted in 2 phases: phase 1 assessed open tibia fracture management characteristics, and phase 2 evaluated the management of soft-tissue wound coverage following open fractures.

Results:
Soft-tissue coverage procedures for Gustilo Anderson Type IIIB fractures were more commonly performed by orthopedic surgeons in Interior Committees than the AATO Exterior Committee. Greater rates of definitive wound coverage within 7 days post-injury were reported in both Interior Committees compared to the Exterior Committee. Plastic surgeons were reported as more available to those in the AATO Exterior Committee group than in the AATO Interior Committees.

Conclusion:
While treatment patterns were evident among groups, differences were identified in the management and timing of soft-tissue coverage in Gustilo Anderson Type IIIB fractures between the Exterior Committee and both Interior Committees. Future targeted educational and surgical hands-on training opportunities that emphasize challenges faced in resource-limited settings may improve the management of open tibia fractures in Argentina.
Endoscopic Over Under Cartilage Tympanoplasty Is Not Inferior to Underlay Cartilage Tympanoplasty
Authors: Erbele Isaac D. , Fink Madelinn R. , Mankekar Gauri , Son Leslie S. , Arriaga Moisés A. , Mehta Rahul 
Published: August 2022

Objective:
Evaluate whether elevating the tympanic membrane from the malleus during endoscopic tympanoplasty may negatively affect postoperative hearing outcomes or perforation rates by comparing 2 similar endoscopic tympanoplasty techniques.

Study Design:
Retrospective cohort.

Setting:
Tertiary care center.

Patients:
Endoscopic over-under cartilage tympanoplasties age and gender matched to endoscopic underlay cartilage tympanoplasties between January 2015 and January 2019. Exclusion criteria included preoperative or intraoperative cholesteatoma, performance of mastoidectomy or ossicular chain reconstruction, and lack of postoperative audiogram.

Interventions:
Endoscopic cartilage tympanoplasty via over-under or underlay technique.

Main Outcome Measures:
Pre- and postoperative pure-tone average and word recognition score, graft success.

Results:
A total of 52 patients were evaluated: 26 endoscopic over-under cartilage tympanoplasties were matched to endoscopic underlay cartilage tympanoplasties. Both groups demonstrated a statistically significant improvement in air conduction hearing (9 dB [P < 0.001] and 6 dB [P < 0.01], respectively), and bone pure-tone average did not worsen in either group (P < 0.001 and P < 0.05, respectively). Postoperative air conduction pure-tone average was statistically noninferior in the over-under group compared with the underlay group (P < 0.05). Reperforation was present in 3 patients (12%) in the underlay group and none in the over-under group, but this difference was not statistically significant (P = 0.24).

Conclusions:
Endoscopic over-under cartilage tympanoplasty effectively closes tympanic membrane perforations and improves hearing, without greater risk than underlay tympanoplasty. Elevating the tympanic membrane from the malleus does not confer worsen hearing outcomes.