bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is the Retromandibular approach a suitable approach to anatomical reduction of unilateral condylar fracture? a prospective non-randomized cohort study
Authors: Mohamed Abdo Ahmed Saleh , Qi Hedeng , Lin Zhaoyu , Sakran Karim Ahmed , Pan Chaobin 
Published: May 2022

Abstract
The aim of this study was to evaluate the efficacy of the retromandibular approach (RMA) to produce three-dimensional (3-D) reduction of the unilateral subcondylar fracture and Temporomandibular Joint (TMJ) functional implication.Methods: A prospective cohort study was designed. Twenty-nine patients with unilateral subcondylar fracture underwent consecutively Open Reduction, and Internal Fixation. The cohorts were divided into two groups; RMA group (n=16, 55.17%) and submandibular approach SMA group (n= 13, 44.82%). The primary outcome was the anatomical 3-D reduction of the condyle. The secondary outcome was to compare the condyle position and inclination finding with TMJ outcomes. Helkimo Index score was used to evaluate the TMJ outcome at six months postoperatively. Result: There was a significant difference between the mediolateral condylar inclination, condylar medial and vertical positions when RMA compared with SMA groups (P < 0.05). The medial joint space was correlated with the medial condylar position in both groups (P < 0.05). The Helkimo Ai and Di was associated with mediolateral condylar inclination in SMG; however, Helkimo Ai was found to be correlated with the RMA group. Conclusion: The current study demonstrates that the RMA could re-establish the anatomical position of the unilateral subcondylar fracture in patients undergoing ORIF. The clinical outcome of the TMJ with RMA was better than SMA
Magnetic anchor technique-assisted thoracoscopic lobectomy in Beagles
Authors: Li Yixing , Zhang Miaomiao , Shi Aihua , Liu Peinan , Zhang Hanzhi , Zhang Yong , Lyu Yi , Yan Xiaopeng 
Published: May 2022

Abstract
In single-port thoracoscopic lobectomy, surgical instruments are likely to collide and interfere with each other. We used magnetic anchor technique to design an anchoring device suitable for thoracoscopic surgery, and verified the safety and feasibility of its use in animal experiments. Ten Beagles were used as models, and magnetic anchor technology was used to assist thoracoscopic lobectomy. During the operation, a self-designed magnetic anchored internal grasper was used in place of the traditional laparoscopic grasping forceps. The operation time, intraoperative blood loss, incidence of postoperative complications, and the effect of intraoperative use of the device were analyzed. All 10 beagles were successfully operated; the mean operation time was 19.7±3.53 min (range 15–26 min), and the postoperative blood loss was <10 mL. No surgical complications occurred. During the operation, the internal grasper was firmly clamped, the auxiliary operation field was well exposed, and the interference of the main operation hole instruments was effectively reduced. We provide preliminary experimental evidence of the safety and feasibility of magnetic anchor technique-assisted thoracoscopic lobectomy.
Metabolismics and Transcriptomics Combined with Confocal Laser Scanning Microscopy Analyzes the Purple and Green Characterization of Salvia miltiorrhiza
Authors: Yang Hanting , Li Hongyan , Li Qian 
Published: May 2022

Abstract
Introduction Salvia miltiorrhiza
is an important model medicinal plant for secondary metabolism research. There is a leaf color variation (purple) in the aboveground part of S. miltiorrhiza in the process of growth and development, which is mostly caused by the loss or variation of structural genes regulating a certain pigment.
Objectives
In order to screen the key genes related to purple traits and explore the differences of their metabolites. In addition to further explore the synthesis, accumulation and transport pathway of flavonoids secondary metabolites in aboveground of S. miltiorrhiza.
Methods
The above ground tissues were analyzed by metabolomics and transcriptomics. And tissue localization and quantitative analysis of flavonoids secondary metabolites were carried out by laser scanning confocal microscope (LSCM).
Results
The results showed PAL、CYP73A/C4H、4CL、ANS、DFR、3AT、HCT and MYB、bHLH、WADS、WRKY transcription families involved in anthocyanin synthesis were highly differentially expressed. In addition, six GST genes, nine ABC transporters, twenty-two MATE genes and three SNARE genes were detected to play a key role in metabolite transport. A variety of flavonoids and glycosidic carbohydrates were found in the metabolites. Finally, tissue localization and quantitative analysis showed that flavonoids were mainly distributed in epidermis, cortex and collenchyma.
Conclusion
The dynamic accumulation model of flavonoids biosynthesis pathway was established, and the biological transport pathway of flavonoids was explored. These findings provide insights into the changes of purple phenotype during the development of S. miltiorrhiza, and provide valuable resources for the study of metabolic regulatory networks.
SND1 confers chemoresistance to cisplatin-induced apoptosis by targeting GAS6-AKT in SKOV3 ovarian cancer cells
Authors: Ha Chuanbo , Hu Lihong , Ren Yuanyuan , Yang Jie , Xin Lingbiao 
Published: May 2022

Abstract
Platinum-based (especially cisplatin) chemotherapy is the main treatment after surgery for ovarian cancer. Although the initial treatment is effective, chemotherapy resistance develops rapidly. Therefore, chemotherapy resistance has always been a huge obstacle in the treatment of ovarian cancer. SND1 is an evolutionarily conserved multifunctional protein that plays a role in promoting tumorigenesis under various stress states. In this study, SKOV3 ovarian cancer cells deficient in SND1 were observed to be more apoptotic and to express more apoptotic protein after treatment with cisplatin, while cells overexpressing SND1 exhibited a decreased number of apoptotic cells and expression of apoptotic proteins. Moreover, SND1 can regulate the expression of GAS6 and then activate the AKT signaling pathway to achieve the regulation of sensitivity to cisplatin-induced apoptosis for ovarian cancer.
Efficacy of Gamma Knife Radiosurgery for Recurrent Gliomas
Authors: Sun Ying , Tao Zhenning , Zhang Haibo , Yan Ying 
Published: May 2022

Abstract
Objective: To investigate the efficacy and safety of gamma knife radiosurgery (GKRS) for recurrent gliomas.Methods: We retrospectively analyzed 88 patients who underwent GKRS in our department from 2009 to 2020, including 56 cases of high-grade glioma (HGG) and 32 cases of low-grade glioma (LGG). The median target volume was 17.8 cm3 (1.6–124.1), the median maximum dose was 25 Gy (13.5–42 Gy), and the median marginal dose was 13.0 Gy (7.5–24.5 Gy). The Kaplan–Meier method was used to calculate the overall survival (OS) and progression free survival (PFS), and log rank test was used to analyze the multivariate prognosis of the Cox proportional-hazards model. Adverse reactions were evaluated according to the Common Terminology Criteria for Adverse Events version 4.03 (CTCAE).Results: The median follow-up time was 79.5 months. The median OS and PFS were 12.5 months and 5.0 months for all patients. The median OS and PFS were 10.0 months and 4.5 months for HGG, respectively. The median OS and PFS were 27.0 months and 12.0 months for LGG, respectively. Multivariate analysis showed that Karnofsky performance status (KPS), pathological grade and the times of GKRS significantly affected OS and PFS. Stratified analysis showed that recurrence time interval (15 months) significantly affected OS and PFS for LGG. KPS significantly affected OS and PFS for HGG, and tumor volume (25 cm3) significantly affected PFS for HGG. No serious adverse events were noted post-GKRS.Conclusions: Gamma knife radiosurgery as a salvage treatment for recurrent gliomas was safe and effective with tolerable adverse reactions.
Enrichment of soybean oil with tocols and γ-oryzanol from rice bran through ohmic heating-assisted ultrasound extraction
Authors: Loypimai Patiwit , Moongngarm Anuchita , Sittisuanjik Kulab , Wongsadee Thippharak 
Published: May 2022

Abstract
Soybean oil enrichment with tocols and γ-oryzanol from rice bran using ohmic heating-assisted ultrasound extraction with soybean oil a green solvent was investigated. Moisturized bran (30% wet basis) samples were ohmically-treated at 100 and 200 V/cm and then subjected to ultrasound extraction using soybean oil a green solvent. Untreated rice bran and bran steamed with an autoclave before ultrasound extraction with soybean oil were used as controls (UB-UASO and CB-UASO). Ohmic heating applied to assist ultrasound soybean oil extraction (OH-UASO) gave higher yields of α- and γ-tocopherols and γ-oryzanol compared to UB-UASO and CB-UASO. Enriched oil obtained by OH-UASO also gave the highest antioxidant activities (DPPH, FRAP and total antioxidant capacity assays), with low concentrations of free fatty acids, thiobarbituric acid (TBA) and peroxide values (PV) during storage for 28 days. Production of edible vegetable oils as a green solvent containing high tocols and γ-oryzanol was achieved, with improved efficiency through ohmic heating.
Spatial ecology of jaguars in Mexico: implications for conservation
Authors: Ceballos Gerardo , González Carlos Cruz , Urios Vicente , Medellin Daniela , Villanueva Heliot Zarza , Morollón Sara , Luja Victor H. 
Published: May 2022

Abstract
ContextMovement ecology contributes valuable information about animal interactions with the environment, and their responses to landscape-level anthropogenic impacts. Big cats are vulnerable to such changes, but the current deficit of information about home range movements, limits the scope of conservation initiatives. Objectives Describe the home range size, interactions, and differences between jaguar populations across its distribution in MexicoMethodsWe used 41,008 GPS-generated data points obtained from 28 tagged jaguars (Panthera onca) in five different states of Mexico over an 18-year period to describe home range size, differences between male and female territories, interactions in overlapping territories, and territory differences among populations. ResultsOur data shows that jaguar home range is smaller than tiger’s but larger than leopard’s. Male mean home range size (285.28 km2, n=13) tends to be larger than that of females (152.2 km2, n = 15), the difference was not statistically significant. While the home range for at least one male was 633.44 km2, contrasted with the much smaller 48.89 km2 for some female jaguars. Data of overlapping ranges showed 34.71% of female territory overlaps male territory, 32.46% of female territory is shared with other females, 18.97% of male territory is shared with other males, and only 16.89% male territory overlaps with female territory. ConclusionsThe absence of significant differences in home range sizes among the habitats suggest jaguar territory is not highly dependent on the type of habitat it occupies. Our findings of the spatial parameters of jaguar movements can be applied to identifying ecological corridors and the design of protected areas for this species.
Community-based distribution of injectable contraceptives in Nigeria: Does the innovation delivery fit stakeholders' preferences?
Authors: Akinyemi Oluwaseun Oladapo , Harris Bronwyn , Kawonga Mary 
Published: May 2022

Abstract
BackgroundThis study explored the fit between the design and delivery of community-based distribution of injectable contraceptive innovation and stakeholders' preferences. Furthermore, it assessed whether and how program implementers engaged potential user groups and community members in the design of innovation delivery.MethodsThis qualitative study was part of a more extensive cross-sectional study on the scale up of the community-based distribution of injectable contraceptives in Gombe, Northeast Nigeria. The authors conducted fifteen in-depth interviews (IDIs), seven key informant interviews (KIIs), and ten focus group discussions (FGDs) between September and November 2016 to obtain data from health workers, religious and traditional leaders, and community members, including users of injectable contraceptives. Additionally, the transcripts were analyzed using thematic analysis for important topics about delivery design and stakeholder preference.ResultsAlthough the innovation was community-based, only a narrow fit was identified between the innovation's design and stakeholders' preferences. However, by continuously engaging with stakeholders, even after the implementation, the delivery of the innovation was modified to consider cultural, religious, and programmatic factors, thereby improving the 'fit.' Modifications included the use of markets as mobile posts to distribute the injectables and to provide healthcare for women, dissemination outreach at women's gatherings, and distribution of contraceptives from community health extension workers' homes. Other modifications involved recruiting young female community volunteers as peer educators, partnering with patent medicine vendors, and social marketing using mobile phones to improve compliance. In addition, community participation through community-based organizations and community gatekeepers took place from the outset, across the planning stages to scale up. ConclusionMost of the modifications to the delivery of this innovation resulted from sociocultural, religious, and programmatic considerations. Therefore, innovation delivery should be context-relevant and cost-effective. Also, there might be a need to combine strategies for synergy and integrate community-based distribution with existing programs and infrastructures.
Moiré Enhanced Potentials in Twisted Transition Metal Dichalcogenide Trilayers Homostructures
Authors: Zheng Haihong , Wu Biao , Li Shaofei , He Jun , Chen Ke-Qiu , Liu Zongwen , Pan Anlian , LIU Yanping 
Published: May 2022

Abstract
Moiré superlattices in the twisted van der Waals materials have become an excellent platform for exploring new quantum phenomena due to the interaction between atomic structure and electronic correlation. Moiré superlattice can generate periodic moiré potential, which can constrain the recombination of excitons, leading to exotic quantum phenomena, including moiré excitons, flat bands, etc., which have been extensively reported in TMDs structures. However, the effect between the modulating of the moiré potential and the number of twisted layers has not been the subject of experimental research yet. Here we synthesized a twisted trilayer homostructure by a dry-transfer method and the enhancement of the moiré potential by the number of twisted layers is investigated. The moiré potential depths of the twisted bilayer and trilayer homostructure are 111 and 212 meV (increased by 91%), which further demonstrate that the depth of the moiré potential can be controlled by adjusting the number of stacked layers. Enhanced moire potential allows observation of moire excitons at 77 K, which are improved by an order of magnitude bigger than those of other moiré excitons(less than 10 K). Our results provide a new method for controllable preparation of moire potentials and a new avenue for further exploration of highly correlated quantum phenomena.
Effective rules placement approach in energy-constrained software defined wireless community networks
Authors: Noutat Soulamite Judith Nouho , Ndie Thomas Djotio 
Published: May 2022

Abstract
In this paper, we propose an effective approach for rules placement in energy-aware software-defined wireless community networks. It consists of defining accurate routing rules at the control plane based on network characteristics and then placing them in routers and switches located in the data plane. The ultimate goal is to minimize the total energy consumption by taking into account the residual energy and memory capacity constraints of nodes. The energy-efficient routing issue is an np-complete problem. It involves finding a path that optimizes the energy consumption to relay each flow from source to destination. The strategy for defining rules and placing them in routers that guides the routing process can lead to high-energy consumption. Our main interest is in energy-sensitive areas where power supply is sometimes very scarce, insufficient, or irregular. Nodes in this context are likely to operate very often with autonomous energy. Under these operating circumstances, the total energy consumption and the residual energy of each node, are very important metrics in the path calculation for the network and nodes' lifetime considered together. We formalize the problem as an integer linear program and propose a greedy heuristic as solution. Based on the experiments performed, evaluation results show that our solution simultaneously extends the lifetime of the network and nodes compared to Djikstra's algorithm.
A Novel Set-up for In-situ Measurement and Mapping of Lubricant Film Thickness in a Model Rolling Bearing Using Interferometry and Ratiometric Fluorescence Imaging
Authors: Chennaoui Mourad , Liang He , Fowell Mark , Kadiric Amir 
Published: May 2022

Abstract
This paper describes a unique experimental set-up constructed for studies of lubricant behaviour in an operating rolling element bearing including in-situ quantitative measurements of film thickness in and around the element-raceway contact. The set-up is based on a deep groove ball bearing in which the outer race is made of sapphire to allow full optical access to the zone in which the rolling elements are loaded against it. This allows direct imaging of lubricant films under both steady-state and transient conditions and at contact pressures and rotational speeds representative of those present in real rolling element bearings. Optical interferometry is used to measure thin EHL films inside the ball-raceway contacts while a specific laser induced fluorescence approach, referred to as ratiometric fluorescence, is implemented to observe the lubricant distribution and quantify its thickness ahead of the ball-raceway contact. Results are presented to validate the accuracy of the method and to investigate the influence of bulk lubricant viscosity and bearing speed on contact film thickness, inlet starvation and lubricant distribution around the ball-raceway contact. To the best of our knowledge, the work described here is the first to directly measure lubricant distribution and EHL film thickness in a ball-raceway contact in an operating radial rolling bearing.
Autobiographical narratives in relation to affect regulation in an Italian sample of patients in an acute phase of Anorexia Nervosa
Authors: Mariani Rachele , Marini Isabella , Trani Michela Di , Catena Carlotta , Patino Francesca , Riccioni Raffaele , Pasquini Massimo 
Published: May 2022

Abstract
Purpose: This research aims to analyze the relationship between emotional regulation and the symbolic process in autobiographical narratives in a group of individuals diagnosed with restrictive Anorexia Nervosa (AN), compared to a non-clinical group. The study is framed within Multiple Code Theory MCT (Bucci, 1997; 2021) which considers mind-body integration. The purposes of this study are to investigate whether AN will show greater alexithymia and emotional dysregulation than the non-clinical group; and whether the specific linguistic and symbolic features, such as somatic-sensory words, affect words, and difficulty in symbolizing process will predict the AN group.Methods: Twenty-nine female participants hospitalized with AN in an acute phase (mean age 19.8 ±4.1) and thirty-six non-clinical female participants (mean age 21 ±2.4) were selected through snow-ball sampling. The participants completed the Toronto Alexithymia Scale (TAS-20), the Profile of Mood of State (POMS), the Emotion Regulation Questionnaire (ERQ), and a Relationship Anecdotes Paradigm Interview (RAP). The Referential Process (RP) Linguistic Measures has been applied to transcribed interviews. A T-test for paired samples and logistic binary regression has been performed.Results: AN presented a significantly higher emotional dysregulation through the ERQ, TAS20 and POMS measures. Specifically, AN showed higher ER expression/suppression strategies, fewer functional cognitive strategies, higher alexithymia, and higher mood dysregulation. Specific linguistic features such as sensory-somatic, affect word, and difficulty in RP symbolizing, predict the AN group (R2 = .349; χ2 = 27,929; df = 3; p = .001).Conclusions: Emotional dysregulation is connected to AN symptoms and autobiographical narratives. The results can help a clinical assessment phase showing specific linguistic features in AN patients.
Experimental models of salivary gland cancer established using organoid culture and patient-derived xenografting
Authors: Aizawa Yoshihiro , Takada Kentaro , Aoyama Jun , Sano Daisuke , Yamanaka Shoji , Seki Masahide , Kuze Yuta , Ramilowski Jordan , Okuda Ryo , Ueno Yasuharu , Nojima Yusuke , Inayama Yoshiaki , Hatakeyama Hiromitsu , Hatano Takashi , Takahashi Hideaki , Nishimura Goshi , Fujii Satoshi , Suzuki Yutaka , Taniguchi Hideki , Oridate Nobuhiko 
Published: May 2022

Abstract
Purpose: Salivary gland carcinoma (SGC) has poor prognosis depending on the histological subtype. However, due to the scarcity of preclinical experimental models, its molecular biology remains largely unknown, hampering the development of new treatment modalities for patients with these malignancies. The aim of this study is to generate human SGC experimental models for multiple histological subtypes using patient-derived xenograft (PDX) and organoid culture techniques. Methods: Tumor specimens from surgically resected SGC were proceeded for the preparation of PDX and patient-derived organoid (PDO). Specimens from SGC PDX were also proceeded for PDX-derived organoid (PDXO). in vivo tumorigenicity was assessed by orthotopic transplantation of SGC organoids. The pathological characteristics of each model were compared to those of the original tumor by Immunohistochemistry analysis. The genetic traits of PDO samples were analyzed by RNA-seq. Results: A series of SGC PDOs, PDX and PDXO models using human SGC tumor section for salivary duct carcinoma, mucoepidermoid carcinoma, and myoepithelial carcinoma were successfully generated. Through passaging, each model was confirmed to almost maintain the pathological characteristics of the original tumor and the genetic traits including transcription profiles, genomic variation and the presence of fusion genes of corresponding histological subtypes. Conclusion: We here described success in the generation of in vitro and in vivo SGC models of multiple histological subtypes using organoid culture and PDX, recapitulating the histological and genetical characteristics of original tumor. Thus, our experimental models of SGC could be a powerful resource for the development of novel therapeutic agents and investigating the molecular biology of these malignancies.