bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and outcomes of COVID-19 patients during B.1.1.529 (Omicron) dominance compared to B.1.617.2 (Delta) in 89 German hospitals
Authors: Leiner Johannes , Pellissier Vincent , Hohenstein Sven , König Sebastian , Schuler Ekkehard , Möller Robert , Nachtigall Irit , Bonsignore Marzia , Hindricks Gerhard , Kuhlen Ralf , Bollmann Andreas 
Published: April 2022

AbstractBackgroundThe SARS-CoV-2 variant of concern B.1.1.529 (Omicron) was first described in November 2021 and soon became the dominant variant worldwide. Existing data suggests a reduced disease severity in comparison to B.1.617.2 (Delta). Differences in characteristics and in-hospital outcomes of patients with COVID-19 in Germany during the Omicron period compared to Delta are not thoroughly studied. Surveillance for severe acute respiratory infections (SARI) represents an integral part of infectious disease control in Germany.MethodsAdministrative data from 89 German Helios hospitals was retrospectively analysed. Laboratory-confirmed SARS-CoV-2 infections were identified by ICD-10-code U07.1 and SARI cases by ICD-10-codes J09-J22. COVID-19 cases were stratified by concomitant SARI. A nine-week observational period between December 6, 2021 and February 6, 2022 was defined and divided into three phases with respect to the dominating virus variant (Delta, Delta to Omicron transition, Omicron). Regression analyses adjusted for age, gender and Elixhauser comorbidities were applied to assess in-hospital patient outcomes.ResultsA total cohort of 4,494 inpatients was analysed. Patients in the Omicron dominance period were younger (mean age 61.6 vs. 47.8; p<0.01), more likely to be female (54.7% vs. 47.5%; p<0.01) and characterized by a lower comorbidity burden (mean Elixhauser comorbidity index 8.2 vs. 5.4; p<0.01). Comparing Delta and Omicron periods, patients were at significantly lower risk for intensive care treatment (adjusted odds ratio 0.64 [0.51-0.8]; p<0.001), mechanical ventilation (adjusted odds ratio 0.38 [0.28-0.51]; p<0.001), and in-hospital mortality (adjusted odds ratio 0.42 [0.32-0.56]; p<0.001). This also applied to the separate COVID-SARI group. During the Delta to Omicron transition, case numbers of COVID-19 without SARI exceeded COVID-SARI.ConclusionPatient characteristics and outcomes differ during the Omicron dominance period as compared to Delta suggesting a reduced disease severity with Omicron infections. SARI surveillance might play a crucial role in assessing disease severity of future SARS-CoV-2 variants.
Environmental filtering and habitat (mis)matching of riverine invertebrate metacommunities
Authors: Murray-Stoker David , Murray-Stoker Kelly M. , Kong Fan Peng , Amanat Fathima 
Published: April 2022

AbstractAimMetacommunities are assembled through a combination of local and regional processes, with the relative importance of the drivers of assembly depending on ecological context. Global change can alter community assembly at both local and regional levels, potentially shifting communities into disequilibrium with their local environmental conditions. In this study, we evaluated the spatial variation in environmental filtering and habitat matching of 1078 riverine macroinvertebrate communities distributed across nine ecoregions within the conterminous United States.LocationConterminous United States.TaxonFreshwater macroinvertebrates.MethodsWe first quantified spatial patterns in environmental filtering, habitat matching, and functional trait diversity. We then used boosted regression trees to identify (1) functional trait predictors of environmental filtering and habitat matching and (2) environmental, landscape, and network variables that predict functional trait abundances.ResultsOur results demonstrated that environmental filtering but not habitat matching varied strongly by ecoregion. We also found that functional trait diversity varied by ecoregion, but not as strongly as the signatures of environmental filtering. We did not identify consistent functional trait predictors for both environmental filtering and habitat matching, with trait predictors instead varying by individual traits, trait categories, and ecoregions. Notwithstanding inconsistent trait predictors, environmental filtering was primarily influenced by habitat preference traits while habitat matching was primarily influenced by both habitat preference and dispersal traits. Predictors of functional traits also varied by trait category and ecoregion, with habitat preference and dispersal traits primarily influenced by network variables.Main conclusionsOur study demonstrates the contingent patterns and drivers of environmental filtering and habitat matching on a macroecological scale. We aim for this work to provide the foundation on which trait-environment relationships can be further quantified and causal explanations established in the context of community disequilibrium and applied to conservation and management of freshwater systems.
CCDC66 regulates primary cilium length and signaling competence via multi-site interactions with transition zone and axonemal proteins
Authors: Conkar Deniz , Odabasi Ezgi , Deretic Jovana , Batman Umut , Frikstad Kari-Anne M. , Patzke Sebastian , Firat-Karalar Elif Nur 
Published: April 2022

AbstractThe primary cilium is a conserved microtubule-based organelle that serves as a hub for many signaling pathways. It functions as part of the centrosome/cilium complex, which also contains the basal body and the centriolar satellites. Little is known about the mechanisms by which the microtubule-based axoneme of the cilium is assembled with proper length and structure, particularly in terms of the activity of microtubule-associated proteins (MAPs) and the crosstalk between the different compartments of the centrosome/cilium complex. Here, we analyzed CCDC66, a MAP implicated in cilium biogenesis and ciliopathies affecting eye and brain. Live-cell imaging revealed that CCDC66 compartmentalizes between centrosomes, centriolar satellites, and the ciliary axoneme and tip during cilium assembly and disassembly. CCDC66 loss-of-function in human cells causes defects in cilium assembly, length and morphology. Notably, CCDC66 interacts with the MAPs and ciliopathy proteins CEP104 and CSPP1 and cooperates with them during axonemal length regulation. Moreover, CCDC66 interacts with the transition zone protein CEP290 selectively at the centriolar satellites. Its loss disrupts basal body recruitment of transition zone proteins and IFT-B machinery and causes defective Hedgehog signaling. Overall, our results establish CCDC66 as a multifaceted regulator of the primary cilium, and propose a mechanistic insight into how the cooperation of ciliary MAPs as well as subcompartments ensures assembly of a functional cilium.
Puf3p facilitates fermentative mitochondrial functions via monosome-enriched nuclear-encoded mitochondrial mRNAs in budding yeast
Authors: Hayashi Sachiko , Iwamoto Kazumi , Yoshihisa Tohru 
Published: April 2022

ABSTRACTYeasts generally grow with a highly glycolytic metabolism and restrain mitochondrial biogenesis except for some Fe/S proteins. Respiratory mitochondrial functions and biosynthesis pathways are well studied, however how cells coordinate basal fermentative mitochondrial functions is not fully understood. We show that a part of nuclear-encoded mitochondrial mRNAs, which preferentially translated in monosomes, are regulated by Puf3p upon glucose-rich media. Especially, of those monosome-enriched nuclear-encoded mitochondrial mRNAs, CAT5/COQ7 mRNA has a variant of the canonical Puf3p binding site on its 3’-UTR. Western blot analysis showed that Puf3p represses the translation of Cat5p regardless of fermentable or respiratory media. In vitro binding assay revealed that Puf3p directly binds to CAT5 mRNA via the non-canonical Puf3p binding site.Mutants harboring the substitution of the non-canonical Puf3p binding site in CAT5 mRNA grew normally but impaired Cat5p expressions apparently, indicating CAT5 mRNA is a bona fide Puf3p target. Overall, Puf3p, a general key modulator for nuclear-encoded mitochondrial mRNAs, fine-tunes translation of a subset of nuclear-encoded mitochondrial mRNAs including mRNAs with non-canonical Puf3p binding sites under the fermentation. This may be required to keeping the fundamental functions of yeast mitochondria at proper levels.
Single-cell colocalization analysis using a deep generative model
Authors: Kojima Yasuhiro , Mii Shinji , Hayashi Shuto , Hirose Haruka , Ishikawa Masato , Akiyama Masashi , Enomoto Atsushi , Shimamura Teppei 
Published: April 2022

1AbstractAnalyzing colocalization of single cells with heterogeneous molecular phenotypes is essential for understanding cell-cell interactions, cellular responses to external stimuli, and their biological functions in diseases and tissues. However, high-throughput methods for identifying spatial proximity at single-cell resolution are practically unavailable. Here, we introduce DeepCOLOR, a computational framework based on a deep generative model that recovers inter-cellular colocalization networks with single cell resolution by the integration of single cell and spatial transcriptomes. It segregates cell populations defined by the colocalization relationships and predicts cell-cell interactions between colocalized single cells. DeepCOLOR could identify plausible cell-cell interaction candidates in mouse brain tissues, human squamous cell carcinoma samples, and human lung tissues infected with SARS-CoV-2 by reconstructing spatial colocalization maps at single-cell resolution. DeepCOLOR is typically applicable to studying cell-cell interactions in any spatial niche. Our newly developed computational framework could help uncover molecular pathways across single cells connected with colocalization networks.
Enabling SAT single pilot operations: tactical separation system design advancements in the COAST project
Authors: Di Vito Vittorio , Torrano Giulia , Cerasuolo Giovanni , Ferrucci Michele 
Published: April 2022

Purpose
This paper aims to describe the advancements of the activities that have been carried out, in the Cost-Optimized Avionics SysTem (COAST) project, to complete the design and in-flight demonstration of the Tactical Separation System (TSS), which is an automatic support system to the pilot’s decision-making, onboard on small air transport (SAT) vehicles under single pilot operations, in the separation management.

Design/methodology/approach
In the framework of the Clean Sky 2 funded project COAST, some enabling technologies for single pilot operations in the EASA CS-23 category vehicles are designed and demonstrated in flight. Among the relevant flight management technologies addressed in the project, the specific one devoted to the real-time support to pilot’s decision-making in maintaining the vehicle self-separation is the TSS, designed by the Italian Aerospace Research Centre.

Findings
The TSS design started in the year 2016 and has been completed in the year 2021 after successful in-flight demonstration in the dedicated flight test campaign. The system has been validated by means of several simulation campaigns and finally demonstrated its effectiveness in providing its intended functionalities (situational awareness, conflict detection, conflict resolution) to the pilot in real flight trials, involving the presence of real conflicting aircraft.

Originality/value
The TSS contributes enabling the implementation of single pilot operations in CS-23 category vehicles, thanks to the possibility to support the pilot with provision of consolidated traffic picture, detection of conflicting surrounding traffic and suggestion of suitable conflict resolution manoeuvre real-time during the flight, through dedicated human–machine interface designed on purpose. The TSS supports the new separation modes that are envisaged in the future SESAR ATM target concept, with particular reference to the possible delegation of the separation responsibility to the pilot.
Proposing a sequential iterative method based on a per-unit model for rotor shape optimization in permanent magnet assisted synchronous reluctance motors
Authors: Jamali Fard Ali , Mirsalim Mojtaba 
Published: April 2022

Purpose
During the design process of synchronous reluctance motors (SynRMs), one crucial step, after its main dimensioning, is optimizing the rotor geometry for maximum average torque and minimum torque ripple. However, because of the complexity of rotor flux-barrier layers geometry, the number of rotor geometrical parameters is high and this step could be quite complex and time-consuming. To obtain a good performance, one needs a robust algorithm to optimize the rotor geometry. The purpose of this paper is to present a sequential iterative method for rotor shape optimization in SynRMs based on the per-unit rotor model to maximize the average torque and minimize the torque ripple.

Design/methodology/approach
In the presented method, at first, rotor geometrical parameters are classified into several groups based on their geometrical similarities, and then optimization is done on these individual groups iteratively. The method starts with an arbitrary feasible rotor geometry and proceeds to optimize it. Because the method’s performance depends on initial rotor geometry, different cases are studied to investigate the convergence and robustness of the method. The MATLAB software is used to implement the optimization algorithm, and the ANSYS Maxwell software is used for the finite element analysis.

Findings
The performance of the proposed method is studied on a three-phase 0.75 kW-1,500 rpm permanent magnet assisted SynRM. The results show that the method improves the average torque while reducing the torque ripple. Even if the method starts with an inappropriate initial rotor geometry, it is robust enough and converges within an acceptable number of iterations.

Originality/value
The value of this paper is in introducing a per-unit rotor model. When the authors optimize the rotor geometry for a specific motor rating, it can be scaled up or down for other ratings with little effort. In this work, the number of rotor poles is four and the number of rotor flux-barrier layers per pole is three. Other combinations could be analyzed in future studies.
Are older applicants less likely to be invited to a job interview? – an experimental study on ageism
Authors: Berde Éva , Mágó Mánuel László 
Published: April 2022

PurposeThe main goal of this paper is to test whether older Hungarian women face age discrimination in the job market. The theoretical framework of this paper measures the level of discrimination and highlights that age discrimination leads to a waste of human resources.Design/methodology/approachTwo pairs of fictitious CVs were created; each pair included a younger (34 years old) and an older woman (60 years old) with an age difference of 26 years. One pair was designed for office assistant positions, the other for economic analyst positions. The contents of the CVs with photos were entirely fabricated except for active email addresses and phone numbers to allow responses to be tracked. LinkedIn accounts were also created for the analysts. Applications were sent over a four-month period from November 2019. The rate of invitation to interviews was analysed with mathematical statistical methods and a small probability model.FindingsThe younger job seekers were invited to interviews about 2.2 times more often than the older ones. Based on the authors’ probability model, employers evaluate the skills of older applicants at only 45–67% of their actual skills.Research limitations/implicationsThe experiment had to be stopped due to the Covid-19 lockdown as there were no new job postings.Originality/valueThe experiment demonstrates that age discrimination exists in Hungary. In addition to traditional audit job applications through HR portals, we used LinkedIn too. The small probability model applies an old framework in a new environment.
Investigating the causes of construction delay on the perspective of organization-sectors involved in the construction industry of Bangladesh
Authors: Nafe Assafi Mohammad , Hoque Md. Ikramul , Hossain Md. Mehrab 
Published: April 2022

PurposeConstruction delay always causes massive damage to the advancing construction industries, which is no different in the case of Bangladeshi construction industries. This paper aims to investigate the major delay factors causing construction delays in public-funded, mixed and private-funded construction projects of Bangladesh. Also, it offers preventive suggestions from expert stakeholders to reduce the recurrence of delays.Design/methodology/approachAt first, an extensive literature review was conducted to identify the thirty-seven major delay factors categorized under seven groups. A questionnaire was then developed for survey at ongoing construction projects at a different division of Bangladesh. Next, data from 110 respondents were collected, and the delay factors were ranked based on the Relative Importance Index (RII); lastly, probable solutions were suggested for top-ranked delay factors based on opinions from expert stakeholders in the construction sector of Bangladesh.FindingsThe overall RII ranking of the 37 delay factors showed “Construction mistakes and defective work,” “Contract modifications by the client” and “Adverse weather condition” as the top three factors causing the delay. For public-funded projects, “Construction mistakes and defective work” and “Slow decision making by a consultant” are the top delay factors. For mixed projects, “Slow decision making of the client” and “Construction mistakes and defective work ranked top, and for private-funded projects, “Financial problems and payment delay of the client” and “Adverse weather condition” ranked top. These nuances of ranking in individual project types ascertain that the causes of delay vary in terms of project features.Practical implicationsThe outcome of this project will help identify the significant delay factors based on their severity of effectiveness associated with public-funded, mixed and private-funded projects in Bangladesh. The suggestions regarding preventing these delay factors obtained through the opinions of expert stakeholders can help reduce the effect of these delays in the context of Bangladesh and in countries where the similarity in construction environment prevails.Originality/valuePreviously, studies on construction delays in Bangladesh focused mainly on identifying the delays using qualitative analysis techniques. This study is based on a unique methodology of integrating quantitative research on delay factor identification and qualitative research on preventive measures following the opinions gathered from expert stakeholders in the construction sector.
Stock return synchronicity in a weak information environment: evidence from African markets
Authors: Kyiu Anthony , Jones Edward , Li Hao 
Published: April 2022

PurposeThis study investigates the level of stock return synchronicity in African markets with the aim of establishing whether, contrary to conventional wisdom, stock return synchronicity can be low in countries with relatively weak information environments.Design/methodology/approachThe authors use a sample of five African countries (Botswana, Ghana, Kenya, Nigeria and South Africa) and a total of 616 firms over the period 2005–2015. This study's main measure of synchronicity is the R2 from a regression of stock returns on index returns. The authors also carry out regression analysis to investigate the main firm-level drivers of synchronicity.FindingsOn average, firms in African markets do not exhibit high levels of stock return synchronicity, providing support for the view that stock return synchronicity can be low in markets with relatively weak transparency. The authors, however, observe an increase in the level of synchronicity during the global financial crisis, notably for Ghana and Kenya. In the regression analysis, the main firm-level driver of synchronicity is firm size, while contrary to some previous studies, ownership structure has no impact. The authors also find evidence of the impact of changes in accounting regulation, notably the mandatory adoption of IFRS, on the level stock synchronicity.Originality/valueThis study contributes to the understanding of stock return synchronicity and how price discovery can vary between different information environments. The authors argue that stock returns in African countries may not always fit the stereotypical view that they are synchronous. The level of synchronicity among firms suggests that corporate events may carry some stock price implications.
Multiaxial fatigue under variable amplitude loadings: review and solutions
Authors: Deng Qing-Yun , Zhu Shun-Peng , He Jin-Chao , Li Xue-Kang , Carpinteri Andrea 
Published: April 2022

PurposeEngineering components/structures with geometric discontinuities normally bear complex and variable loads, which lead to a multiaxial and random/variable amplitude stress/strain state. Hence, this study aims how to effectively evaluate the multiaxial random/variable amplitude fatigue life.Design/methodology/approachRecent studies on critical plane method under multiaxial random/variable amplitude loading are reviewed, and the computational framework is clearly presented in this paper.FindingsSome basic concepts and latest achievements in multiaxial random/variable amplitude fatigue analysis are introduced. This review summarizes the research status of four main aspects of multiaxial fatigue under random/variable amplitude loadings, namely multiaxial fatigue criterion, method for critical plane determination, cycle counting method and damage accumulation criterion. Particularly, the latest achievements of multiaxial random/variable amplitude fatigue using critical plane methods are classified and highlighted.Originality/valueThis review attempts to provide references for further research on multiaxial random/variable amplitude fatigue and to promote the development of multiaxial fatigue from experimental research to practical engineering application.