bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantifying Award Network and Career Development in the Movie Industry
Authors: Liu Yixuan , Ma Yifang 
Published: June 2022

In show business, awards are conferred to persons and films to provide incentives to performers’ future career development through periodic film festivals and events. In this work, we focused on exploring the growth and dynamics of the film award system, the structure of the award network, and the relationships between historical performance, collaborations, and future career success of performers in the movie industry. We collected data from IMDb, which covers more than 3.5K movie events for 520K individuals with their award-winning and career records for over 90 years. By using network analysis and regression models, we find several novel results. At first, we found the exponential proliferation of awards across all genres of films and all professions of individuals and the uneven distribution of the number of awards in careers across time. More than 30% of the performers have won multiple awards. Second, we built an award network to reveal the interlocks between awards based on multiple award-winning phenomena. We found that for prestigious awards, 47% of the linkages were over-representative than the expectations from the null model. Furthermore, the performers’ collaboration network was highly clustered, exhibiting a high propensity of linkages between awarded performers. Lastly, our regression models revealed that multiple factors were related to performers’ early career success and award winning. Specifically, we showed that along with the performers’ historical achievements, their collaborators serve an important role in award winning after being nominated, with the scope and depth of the impact differing in the awards’ prestige. This work has strong implications for the harmonious dynamics of the movie industry and the career development of performers.
eNAMPT Neutralization Preserves Lung Fluid Balance and Reduces Acute Renal Injury in Porcine Sepsis/VILI-Induced Inflammatory Lung Injury
Authors: Sammani Saad , Bermudez Tadeo , Kempf Carrie L. , Song Jin H. , Fleming Justin C , Reyes Hernon Vivian , Hufford Matthew , Tang Lin , Cai Hua , Camp Sara M. , Natarajan Viswanathan , Jacobson Jeffrey R. , Dudek Steven M. , Martin Diego R. , Karmonik Christof , Sun Xiaoguang , Sun Belinda , Casanova Nancy G. , Bime Christian , Garcia Joe G. N. 
Published: June 2022

Background: Numerous potential ARDS therapeutics, based upon preclinical successful rodent studies that utilized LPS challenge without mechanical ventilation, have failed in Phase 2/3 clinical trials. Recently, ALT-100 mAb, a novel biologic that neutralizes the TLR4 ligand and DAMP, eNAMPT (extracellular nicotinamide phosphoribosyltransferase), was shown to reduce septic shock/VILI-induced porcine lung injury when delivered 2 h after injury onset. We now examine the ALT-100 mAb efficacy on acute kidney injury (AKI) and lung fluid balance in a porcine ARDS/VILI model when delivered 6 h post injury.Methods/Results: Compared to control PBS-treated pigs, exposure of ALT-100 mAb-treated pigs (0.4 mg/kg, 2 h or 6 h after injury initiation) to LPS-induced pneumonia/septic shock and VILI (12 h), demonstrated significantly diminished lung injury severity (histology, BAL PMNs, plasma cytokines), biochemical/genomic evidence of NF-kB/MAP kinase/cytokine receptor signaling, and AKI (histology, plasma lipocalin). ALT-100 mAb treatment effectively preserved lung fluid balance reflected by reduced BAL protein/tissue albumin levels, lung wet/dry tissue ratios, ultrasound-derived B lines, and chest radiograph opacities. Delayed ALT-100 mAb at 2 h was significantly more protective than 6 h delivery only for plasma eNAMPT while trending toward greater protection for remaining inflammatory indices. Delayed ALT-100 treatment also decreased lung/renal injury indices in LPS/VILI-exposed rats when delivered up to 12 h after LPS.Conclusions: These studies indicate the delayed delivery of the eNAMPT-neutralizing ALT-100 mAb reduces inflammatory lung injury, preserves lung fluid balance, and reduces multi-organ dysfunction, and may potentially address the unmet need for novel therapeutics that reduce ARDS/VILI mortality.
Oral Sensory Sensitivity Influences Attentional Bias to Food Logo Images in Children: A Preliminary Investigation
Authors: Wallisch Anna , Little Lauren M. , Bruce Amanda S. , Salley Brenda 
Published: June 2022

BackgroundChildren’s sensory processing patterns are linked with their eating habits; children with increased sensory sensitivity are often picky eaters. Research suggests that children’s eating habits are also partially influenced by attention to food and beverage advertising. However, the extent to which sensory processing influences children’s attention to food cues remains unknown. Therefore, we examined the attentional bias patterns to food vs. non-food logos among children 4–12 years with and without increased oral sensory sensitivity.DesignChildren were categorized into high (n = 8) vs. typical (n = 36) oral sensory sensitivity by the Sensory Profile-2. We used eye-tracking to examine orientation and attentional bias to food vs. non-food logos among children with high vs. typical oral sensory sensitivity. We used a mixed model regression to test the influence of oral sensory sensitivity to attentional biases to food vs. non-food logos among children.ResultsResults showed that children with high oral sensory sensitivity showed attentional biases toward non-food logos; specifically, children with high oral sensory sensitivity oriented more quickly to non-food logos as compared to food logos (p &lt; 0.05), as well as spent more time looking at non-food logos as compared to food logos (p &lt; 0.05). Findings were in the opposite direction for children with typical oral sensory sensitivity.ConclusionSensory sensitivity may be an individual characteristic that serves as a protective mechanism against susceptibility to food and beverage advertising in young children.
Mediating Role of Psychological Capital in the Relationship Between Social Support and Self-Neglect Among Chinese Community-Dwelling Older Adults
Authors: Zhao Binyu , Wang Hangsai , Xie Chunqi , Huang Xianhong , Cao Meijuan 
Published: June 2022

ObjectivesSelf-neglect in older adults has become an important public health issue and is associated with negative health outcomes and increased morbidity and mortality. Social support has been recognized as a prominent predictor of self-neglect, but the underlying mechanism is unclear. This study aims to investigate and illustrate the associations among social support, psychological capital, and self-neglect.MethodsThis study used a cross-sectional convenience sampling design. A total of 511 older adults were recruited in Chinese communities. Spearman’s correlation coefficient and hierarchical multiple regression analysis were performed to assess the influencing factors of self-neglect. A structural equation model was applied to test the hypothesized mediation model.ResultsSocial support and psychological capital were found to be negatively related to self-neglect. Social support and psychological capital explained 5.1 and 11.9% of the incremental variances of older adults’ self-neglect, respectively. Psychological capital acts as a mediator between social support and self-neglect.ConclusionSelf-neglect among older adults is a rising problem in China. Social support and higher psychological capital could decrease the risk of self-neglect in older adults. It is crucial to improve social networks and facilitate psychological interventions to reduce such self-neglect.
Combining S100B and Cytokines as Neuro-Inflammatory Biomarkers for Diagnosing Generalized Anxiety Disorder: A Proof-of-Concept Study Based on Machine Learning
Authors: Shen Zhongxia , Cui Lijun , Mou Shaoqi , Ren Lie , Yuan Yonggui , Shen Xinhua , Li Gang 
Published: June 2022

IntroductionS100 calcium-binding protein B (S100B) is a neurotrophic factor that regulates neuronal growth and plasticity by activating astrocytes and microglia through the production of cytokines involved in Generalized Anxiety Disorder (GAD). However, few studies have combined S100B and cytokines to explore their role as neuro-inflammatory biomarkers in GAD.MethodsSerum S100B and cytokines (IL-1β, IL-2, IL-4, and IL-10) of 108 untreated GAD cases and 123 healthy controls (HC) were determined by enzyme-linked immunosorbent assay (ELISA), while Hamilton Anxiety Rating Scale (HAMA) scores and Hamilton Depression Rating Scale (HAMD) scores were measured to evaluate anxiety and depression severity. This was used to help physicians identify persons having GAD. Machine learning techniques were applied for feature ordering of cytokines and S100B and the classification of persons with GAD and HC.ResultsThe serum S100B, IL-1β, and IL-2 levels of GAD cases were significantly lower than HC (P &lt; 0.001), and the IL-4 level in persons with GAD was significantly higher than HC (P &lt; 0.001). At the same time, IL-10 had no significant difference between the two groups (P = 0.215). The feature ranking distinguishing GAD from HC using machine learning ranked the features in the following order: IL-2, IL-1β, IL-4, S100B, and IL-10. The accuracy of S100B combined with IL-1β, IL-2, IL-4, and IL-10 in distinguishing persons with GAD from HC was 94.47 ± 2.06% using an integrated back propagation neural network based on a bagging algorithm (BPNN-Bagging).ConclusionThe serum S-100B, IL-1β, and IL-2 levels in persons with GAD were down-regulated while IL-4 was up-regulated. The combination of S100B and cytokines had a good diagnosis value in determining GAD with an accuracy of 94.47%. Machine learning was a very effective method to study neuro-inflammatory biomarkers interacting with each other and mediated by plenty of factors.
Prediction Model for Urinary Tract Infection in Pediatric Urological Surgery Patients
Authors: Chen Yi , Ge Xiao-Hua , Yu Qun , Wang Ying , Zhu Sheng-Mei , Yuan Jia-Ni , Zong Wen 
Published: June 2022

BackgroundUrinary tract infection (UTI) is a common complication in pediatric urological surgery patients and is associated with long-term sequelae, including subsequent recurrent infections and renal scarring. In this study, we aimed to explore the risk factors for UTI in pediatric urological surgery patients and construct a predictive model for UTI.Materials and MethodsA total of 2,235 pediatric patients who underwent urological surgery at a tertiary hospital between February 2019 and January 2020 were included. A multivariate logistic regression model was applied to identify the predictive factors, and a predictive model was constructed using a receiver operating characteristic curve. A multifactorial predictive model was used to categorize the risk of UTI based on the weight of the evidence.ResultsA total of 341 patients with UTI were identified, which corresponded to a prevalence of 15.26% in pediatric urological surgery patients. Multivariate analysis identified six significant risk factors for UTI, including age &lt;12.0 months, upper urinary tract disease, not using an indwelling drainage tube, hospital stay ≥10 days, administration of two or more types of antibiotics, and stent implantation. A combination of the aforementioned factors produced an area under the curve value of 88.37% for preventing UTI in pediatric urological surgery patients. A multifactorial predictive model was created based on the combination of these factors.ConclusionsThe constructed multifactorial model could predict UTI risk in pediatric urological surgery patients with a relatively high predictive value.
Prevalence of Myopia and Its Associated Factors Among Japanese Preschool Children
Authors: Matsumura Saiko , Dannoue Kazuhiko , Kawakami Momoko , Uemura Keiko , Kameyama Asuka , Takei Anna , Hori Yuichi 
Published: June 2022

PurposeTo investigate the prevalence of myopia and factors associated with spherical equivalent (SE), axial length (AL), and axial length to corneal radius of curvature (AL/CR) ratio among Japanese preschool children.Study DesignProspective observational study.MethodsThis cross-sectional study evaluated subjects aged 4–6 years from a preschool. Non-cycloplegic autorefraction was measured using the Spot Vision Screener, while AL and corneal radius (CR) were measured using the Myopia Master. Parental myopia and environmental factors were investigated using the myopia-related factor questionnaire. The worse eye with higher myopic SE was chosen for analysis, and multiple linear regression models was performed using AL, SE, and AL/CR ratio as dependent variables.ResultsA total of 457 out of 514 participants (239 males, 52.3%) aged 4–6 years (mean 4.77 ± 0.65 years) were included. The mean SE was 0.13 ± 0.63 D, AL was 22.35 ± 0.67 mm, CR was 7.76 ± 0.25 mm, and AL/CR ratio was 2.88 ± 0.72. The overall prevalence of myopia and high myopia were 2.9 and 0.2%, respectively. Multiple regression analysis showed that myopic SE was significantly associated with male sex (β = −0.14, p = 0.02) and parental myopia (β = −0.15, p = 0.04). Meanwhile, longer AL was significantly associated with older age (β = 0.13, p = 0.02), male sex (β = 0.44, p &lt; 0.001), parental myopia (β = 0.24, p = 0.01), and screen time (including smartphones, tablets, and computers) (&gt;1 h, β = 0.14, p = 0.04). A higher AL/CR was significantly associated with older age (β = 0.02, p &lt; 0.001), male sex (β = 0.03, p &lt; 0.001), ratio and parental myopia (β = 0.03, p = 0.02).ConclusionThe prevalence of myopia and high myopia were 2.9 and 0.2%, respectively, among Japanese preschool children in 2021. Longer AL was associated with older age, male sex, parental myopia, and screen time in children aged 4–6 years. Children with a high risk of myopia can be identified early based on parental myopia information for early prevention.
Eye Movements During Comprehension in Virtual Reality: The Influence of a Change in Point of View Between Auditory and Visual Information in the Activation of a Mental Model
Authors: Drai-Zerbib Véronique , Bernigaud Léa , Gaston-Bellegarde Alexandre , Boucheix Jean-Michel , Baccino Thierry 
Published: June 2022

This paper provides new research perspectives in the field of multimodal comprehension (auditory crossing visual information) by using immersion and incorporating eye tracking in a virtual reality environment. The objective is to investigate the influence of a change in narrative perspective (point of view) during the activation of a mental model underlying comprehension between visual and auditory modalities. Twenty-eight participants, equipped with a headset SMI HMD HTC eye-tracking 250 Hz watched 16 visual scenes in virtual reality accompanied by their corresponding auditory narration. The change in perspective may occur either in the visual scenes or in listening. Mean fixations durations on typical objects of the visual scenes (Area of Interest) that were related to the perspective shift were analyzed as well as the free recall of narratives. We split each scene into three periods according to different parts of the narration (Before, Target, After), the target was where a shift in perspective could occur. Results shown that when a visual change of perspective occurred, mean fixation duration was shorter (compared to no change) for both Target and After. However, when auditory change of perspective occurred, no difference was found on Target, although during After, mean fixation duration was longer (compared to no change). In the context of 3D video visualization, it seems that auditory processing prevails over visual processing of verbal information: The visual change of perspective induces less visual processing of the Area of Interest (AOIs) included in the visual scene, but the auditory change in perspective leads to increased visual processing of the visual scene. Moreover, the analysis showed higher recall of information (verbatim and paraphrase) when an auditory change in perspective was coupled with no visual change of perspective. Thus, our results indicate a more effective integration of information when there is an inconsistency between the narration heard and viewed. A change in perspective, instead of creating comprehension and integration difficulties, seems to effectively raise the attention and induce a shorter visual inspection. These results are discussed in the context of cross-modal comprehension.
Weighted Gene Co-Expression Network Analysis Identifies Key Modules and Central Genes Associated With Bovine Subcutaneous Adipose Tissue
Authors: Sheng Hui , Pan Cuili , Wang Shuzhe , Yang Chaoyun , Zhang Junxing , Hu Chunli , Hu Honghong , Feng Xue , Yang Mengli , Lei Zhaoxiong , Gao Yuhong , Wang Zhong , Ma Yun 
Published: June 2022

BackgroundFat deposition is an important economic trait in livestock and poultry production. However, the relationship between various genes and signal pathways of fat deposition is still unclear to a large extent. The purpose of this study is to analyze the potential molecular targets and related molecular pathways in bovine subcutaneous adipose tissue.ResultsWe downloaded the GSE116775 microarray dataset from Gene Expression Omnibus (GEO). The weighted gene co-expression network (WGCNA) was used to analyze the gene expression profile, and the key gene modules with the highest correlation with subcutaneous adipose tissue were identified, and the functional enrichment of the key modules was analyzed. Then, the “real” Hub gene was screened by in-module analysis and protein–protein interaction network (PPI), and its expression level in tissue samples and adipocytes was verified. The study showed that a total of nine co-expression modules were identified, and the number of genes in these modules ranged from 101 to 1,509. Among them, the blue module is most closely related to subcutaneous adipose tissue, containing 1,387 genes. These genes were significantly enriched in 10 gene ontologies including extracellular matrix organization, biological adhesion, and collagen metabolic process, and were mainly involved in pathways including ECM-receptor interaction, focal adhesion, cAMP signaling pathway, PI3K-AKT signaling pathway, and regulation of lipolysis in adipocytes. In the PPI network and coexpression network, five genes (CAV1, ITGA5, COL5A1, ABL1, and HSPG2) were identified as “real” Hub genes. Analysis of Hub gene expression by dataset revealed that the expression of these Hub genes was significantly higher in subcutaneous adipose tissue than in other tissues. In addition, real-time fluorescence quantitative PCR (qRT-PCR) analysis based on tissue samples and adipocytes also confirmed the above results.ConclusionIn this study, five key genes related to subcutaneous adipose tissue were discovered, which laid a foundation for further study of the molecular regulation mechanism of subcutaneous adipose tissue development and adipose deposition.
Life Satisfaction of Rural-To-Urban Migrants: Exploring the Influence of Socio-Demographic and Urbanisation Features in China
Authors: Zhang Xiangjing , Zhou Wusi 
Published: June 2022

Objectives: China has experienced an ongoing urbanisation that associated with spatial transformation and personal changes, which are expected to have direct or indirect impacts on migrants’ health and well-being. This study aims to investigate their life satisfaction and the significant influences.Method: A quantitative research strategy was adopted, with the questionnaire survey towards 877 migrants across Hangzhou and Ningbo cities. Descriptive statistics showed migrants’ life satisfaction, socio-demographic characteristics and urbanisation features. Three logistic regression models examined key factors that influenced life satisfaction.Results: Over one third of migrants were unsatisfied with their life. They mainly received education lower than high school and had an annual household income less than 60k. Comparatively, migrants, who worked in formal sectors, moved into resettlement communities and adapted to city life, tended to have higher levels of life satisfaction.Conclusion: There should be an improvement in migrants’ life satisfaction. This could be achieved by building up their educational level and financial capability. Meanwhile, positive actions such as professional training are required to maximise their participation in formal sectors as well as community life.
Factors Influencing Pedestrian Smartphone Use and Effect of Combined Visual and Auditory Intervention on “Smombies”: A Chinese Observational Study
Authors: Hao Qing-hong , Wang Yang , Zhou Ming-Ze , Yi Ting , Cui Jia-Rui , Gao Ping , Qiu Mi-Mi , Peng Wei , Wang Jun , Tu Yang , Chen Ya-Lin , Li Hui , Zhu Tian-Min 
Published: June 2022

Objective: This was a large-scale multicenter study with two objectives. One was to study the factors influencing pedestrian smartphone use while crossing roads, and the other was to study the effect of combined visual and auditory intervention on smartphone zombies (smombies) at crossroads.Methods: This study was conducted in four different Chinese cities. By observing pedestrians crossing intersections, the weather, time, and characteristics of the pedestrians were recorded by four researchers. Then, its influencing factors and the effects of the intervention were studied in two consecutive periods.Results: A total of 25,860 pedestrians (13,086 without intervention and 12,774 with visual and auditory intervention) were observed in this study. Logistic regressions showed that gender, age of the pedestrians, weather, and time were the factors influencing smombies crossing roads. The number of smartphone users decreased from 4,289 to 3,579 (28.1%) (χ2 = 69.120, p &lt; 0.001) when the intervention was conducted.Conclusion: Based on large-sample, multicenter research, this study revealed the factors influencing pedestrian smartphone use while crossing roads, contributing to our understanding of the current situation of smombies in China. Furthermore, the effect of visual and auditory intervention was demonstrated, providing a new paradigm for global prevention of smombie behavior.
Inventarisasi Hama dan Musuh Alami pada Tanaman Padi di Kecamatan Pulau Laut Timur
Authors: Octaviana Ismi , Ekawati Silvi 
Published: June 2022

Hama merupakan hewan yang menyebabkan kerusakan pada tanaman dan dapat berperan sebagai vektor penyakit. Pengelolaan Hama Terpadu (PHT) merupakan konsep yang tepat dalam mengendalikan hama. Pemantauan lahan secara rutin merupakan hal penting untuk memperhatikan perkembangan populasi hama, musuh alami, dan lingkungan suatu lahan. Sehingga, pengambilan keputusan dalam mengendalikan hama dapat terlaksana secara tepat dan cepat. Pengamatan ini bertujuan untuk mengetahui jenis serangga hama dan musuh alami yang terdapat pada tanaman padi di Desa Teluk Mesjid, Kecamatan Pulau Laut Timur, Kabupaten Kotabaru, Kalimantan Selatan. Penentuan sampel tanaman dilakukan dengan metode diagonal yang berjumlah 10 sampel tanaman. Pengumpulan data dilakukan dengan pengamatan secara langsung (visual). Hasil pengamatan menunjukkan bahwa serangga hama yang ditemukan di pertanaman padi sebanyak 8 jenis serangga hama dengan rata-rata populasi tertinggi terdapat pada hama Wereng Batang Coklat 0,313 ekor per tiga varietas dan Hama Putih Palsu 0,166 ekor per tiga varietas. Rata-rata populasi hama yang ditemukan berbeda pada setiap varietas padi. Varietas padi dengan serangan hama terendah adalah varietas Nutri Zinc, varietas dengan serangan hama tertinggi adalah varietas Inpari 32, dan varietas dengan serangan hama tertinggi kedua adalah varietas Inpara 2. Sedangkan, musuh alami yang ditemukan di pertanaman padi sebanyak 13 jenis.