bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autocatalytic Surface Reduction‐Assisted Synthesis of PtW Ultrathin Alloy Nanowires for Highly Efficient Hydrogen Evolution Reaction
Authors: Gao Lei , Yang Zhilong , Sun Tulai , Tan Xin , Lai Wenchuan , Li Mengfan , Kim Jeonghyeon , Lu Yang‐Fan , Choi Sang‐Il , Zhang Wenhua , Ma Chao , Smith Sean C. , Zhou Yi‐Ge , Huang Hongwen 
Published: January 2022

AbstractAlloying noble metal catalysts with early transition metals (ETMs) has shown great promise by simultaneously boosting catalytic activity and durability because of their strong electronic interactions. However, the very negative reduction potential of ETMs has posed great challenges for the synthesis of the desired alloy catalysts, not to mention the structure‐controlled synthesis. Here an autocatalytic surface reduction‐assisted strategy is reported to realize the controllable synthesis of ultrathin PtW alloy nanowires (NWs). The experimental evidence and density functional theory (DFT) calculations demonstrate that the preformed Pt NWs in the synthesis serve as the catalyst to facilitate the reduction of Wx+ species through the autocatalytic surface reduction mechanism. Using the alkaline hydrogen evolution reaction (HER) as a model reaction, the as‐synthesized PtW NWs/C catalyst shows an ultralow overpotential of 18 mV at 10 mA cm–2 and a high mass activity of 6.13 A mg–1Pt at an overpotential of 100 mV, ranking it among the most active catalysts. The dual roles of alloyed W atoms are further uncovered by theoretical simulations, involving the ensemble effect for accelerating H2O dissociation and a ligand effect for optimizing the hydrogen adsorption strength.
Cystic Fibrosis Foundation otolaryngology care multidisciplinary consensus recommendations
Authors: Kimple Adam J. , Senior Brent A. , Naureckas Edward T. , Gudis David A. , Meyer Ted , Hempstead Sarah E. , Resnick Helaine E. , Albon Dana , Barfield Wayne , Benoit Margo McKenna , Beswick Daniel M. , Callard Eliza , Cofer Shelagh , Downer Veronica , Elson E. Claire , Garinis Angela , Halderman Ashleigh , Hamburger Lisa , Helmick Meagan , McCown Michael , McKinzie Cameron J. , Phan Hanna , Rodriguez Kenneth , Rubenstein Ronald C. , Severin Ashley , Shah Gopi , Shenoy Ambika , Sprouse Brittney , Virgin Frank , Woodworth Bradford A. , Lee Stella E. 
Published: January 2022

AbstractBackgroundCystic fibrosis (CF) is a multisystem disease that often requires otolaryngology care. Individuals with CF commonly have chronic rhinosinusitis but also present with hearing loss and dysphonia. Given these manifestations of CF, otolaryngologists are frequently involved in the care of patients with CF; however, there is limited consensus on optimal management of sinonasal, otologic, and laryngologic symptoms.MethodsThe Cystic Fibrosis Foundation convened a multidisciplinary team of otolaryngologists, pulmonologists, audiologists, pharmacists, a social worker, a nurse coordinator, a respiratory therapist, two adults with CF, and a caregiver of a child with CF to develop consensus recommendations. Workgroups developed draft recommendation statements based on a systematic literature review, and a ≥80% consensus was required for acceptance of each recommendation statement.ResultsThe committee voted on 25 statements. Eleven statements were adopted recommending a treatment or intervention, while five statements were formulated recommending against a specific treatment or intervention. The committee recommended eight statements as an option for select patients in certain circumstances, and one statement did not reach consensus.ConclusionThese multidisciplinary consensus recommendations will help providers navigate decisions related to otolaryngology consultation, medical and surgical management of CF‐CRS, hearing, and voice in individuals with CF. A collaborative and multidisciplinary approach is advocated to best care for our patients with CF. Future clinical research is needed utilizing standardized, validated outcomes with comprehensive reporting of patient outcome, effects of modulator therapies, and genetic characteristics to help continue to advance care, decrease morbidity, and improve the quality of life for individuals with CF.
Circular RNAs in pulmonary hypertension: Emerging biological concepts and potential mechanism
Authors: Wang Qian , Sun Yuanyuan , Zhao Qinhua , Wu Wenhui , Wang Lan , Miao Yuqing , Yuan Ping 
Published: January 2022

AbstractCircular RNAs (circRNAs) are endogenous RNAs with a covalently closed single‐stranded transcript. They are a novel class of genomic regulators that are linked to many important development and disease processes and are being pursued as clinical and therapeutic targets. Using the most powerful RNA sequencing and bioinformatics techniques, a large number of circRNAs have been identified and further functional studies have been performed. It is known that circRNAs act as potential biomarkers, sponges for microRNAs (miRNAs) and RNA‐binding proteins (RBPs), and regulators of mRNA transcription. They also participate in the translation of peptides or proteins. Many types of circRNAs are dysregulated in plasma or lung tissues, and they may be involved in regulating the proliferation and apoptosis of pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs), leading to pulmonary vascular remodeling in pulmonary hypertension (PH). One possible mechanism is that circRNAs can regulate the function of PAECs and PASMCs by acting as miRNA sponge. However, other potential mechanisms of action of circRNAs are still being actively explored in PH. This paper presents a systematic review of the biogenesis, biological characterization, relevant underlying functions, and future perspectives for studies of circRNAs in the pathogenesis of PH.
Identification of a Two‐Coordinate Iron(I)–Oxalate Complex
Authors: Mayer Martin , Vankova Nina , Stolz Ferdinand , Abel Bernd , Heine Thomas , Asmis Knut R. 
Published: January 2022

AbstractExotic oxidation states of the first‐row transition metals have recently attracted much interest. In order to investigate the oxidation states of a series of iron–oxalate complexes, an aqueous solution of iron(III) nitrate and oxalic acid was studied by infrared free liquid matrix‐assisted laser desorption/ionization as well as ionspray mass spectrometry. Here, we show that iron is not only detected in its common oxidation states +II and +III, but also in its unusual oxidation state +I, detectable in both positive‐ion and in negative‐ion modes, respectively. Vibrational spectra of the gas phase anionic iron oxalate complexes [FeIII(C2O4)2]−, [FeII(C2O4)CO2]−, and [FeI(C2O4)]− were measured by means of infrared photodissociation spectroscopy and their structures were assigned by comparison to anharmonic vibrational spectra based on second‐order perturbation theory.
Polyzwitterionic Hydrogels for Efficient Atmospheric Water Harvesting
Authors: Lei Chuxin , Guo Youhong , Guan Weixin , Lu Hengyi , Shi Wen , Yu Guihua 
Published: January 2022

AbstractAtmospheric water harvesting (AWH) is regarded as one of the promising strategies for freshwater production desirable to provide sustainable water for landlocked and arid regions. Hygroscopic materials have attracted widespread attention because of their water harvesting performance. However, the introduction of many inorganic salts often leads to aggregation and leakage issues in practical use. Here, polyzwitterionic hydrogels are developed as an effective AWH material platform. Via anti‐polyelectrolyte effects, the hygroscopic salt coordinated with polymer chains could capture moisture and enhance the swelling property, leading to a strong moisture sorption capacity. The hydrogel shows superior AWH performance (0.62 g g−1, 120 minutes for equilibrium at 30 % relative humidity) and produces 5.87 L kg−1 freshwater per day. It is anticipated that the polyzwitterionic hydrogels with unique salt‐responsive properties could provide new insights into the design and synthesis of next‐generation AWH materials.
Construction of porous poly (aryl sulfide sulfone) film with low dielectric constant and excellent mechanical property
Authors: Zhu Chuanren , Wei Zhimei , Wang Xiaojun , Long Shengru , Zhang Gang , Yang Jie 
Published: January 2022

AbstractThe low dielectric constant and excellent mechanical property polymer film plays important roles in the high‐speed integrated circuits. In this work, porous poly (aryl sulfide sulfone) (PASS) films with different pore regularities and distributions were systematically fabricated via a combination process with solvent evaporation, wet induced phase separation, and hot pressing. It is found that the macroporous structure of PASS films changed from irregular shape with large pore size distribution to regular shape with small pore size distribution and the sponge‐like pore structure disappeared then formed a dense layer by controlling the time of solvent evaporation and hot pressing, to realize the effective control of the pore structure. The optimal PASS porous film D3 which was heated for 25 min and then hot pressed for 4 min has a low dielectric constant (2.44) and dielectric loss (0.010), high tensile strength (62.14 MPa) and breakdown strength (139.32 kV/mm), and low water absorption (0.54%). The comprehensive excellent properties are beneficial to the application of PASS films in microelectronic devices.
Preparation ofAl2O3/PDA/Pebax membrane modified by (C3NH2MIm)(PF6) for improvingCO2separation performance
Authors: Yan Hailong , Liu Hongjing , Li Zhuo , Yu Dan , Wei Cunhua , Gao Yingjia , Yao Hui 
Published: January 2022

AbstractMixed matrix membranes (MMMs) are currently the focus of research due to their possible high separation performance in separating CO2process. However, inorganic nanomaterials are easy to agglomerate so as to affect CO2separation performance. In order to overcome the agglomeration of nanomaterials in MMMs, a new filler, Al2O3/PDA‐TIL, was prepared, in which ionic liquid (TIL) was introduced on the surface of nano‐Al2O3by TIL grafting polydopamine coated on aluminum oxide. And a new type of Al2O3/PDA‐TIL/Pebax MMMs membrane was prepared by the blend of new fillers and Pebax. The properties of MMMs prepared were characterized by SEM, FTIR, XRD, XPS, etc. Results showed that TIL had reacted with PDA to form Schiff base structure, indicating that TIL had been successfully grafted onto PDA coated on Al2O3. As a result, TIL on the surface Al2O3successfully reduced the agglomeration of Al successfully reduced the agglomeration of Al2O3in the membrane and improved the separation of CO2. The gas permeability test results showed that the CO2permeability of MMMs increased from 60.69 Barrer to 101.12 Barrer, and the CO2/N2selectivity increased from 49.34 to 79 at 30°C and 0.1 MPa. Therefore, Al2O3/PDA‐TIL/Pebax membrane has a good application prospect in CO2separation process.
Decreased interoceptive accuracy in children with autism spectrum disorder and with comorbid attention deficit/hyperactivity disorder
Authors: Yang Han‐xue , Zhou Han‐yu , Li Ying , Cui Yong‐hua , Xiang Yang , Yuan Rong‐man , Lui Simon S. Y. , Chan Raymond C. K. 
Published: January 2022

AbstractInteroception refers to the awareness of internal physiological state. Several previous studies reported that people with autism spectrum disorders (ASD) and adults with attention‐deficit/hyperactivity disorder (ADHD) have diverse patterns of interoception, but the extent of literature is limited and inconsistent. This study aimed to investigate the interoceptive accuracy (IA) in children with ASD, children with comorbid ASD and ADHD, and typically developing (TD) children with high and low levels of autistic traits. We administered the eye‐tracking interoceptive accuracy task (EIAT) to 30 children with ASD, 20 children with comorbid ASD and ADHD, and 63 TD controls with high and low levels of autistic traits. Parent‐report scales concerning ASD and ADHD symptoms were collected. ASD children with and without comorbid ADHD both exhibited lower IA than TD children. Reduced IA was also found in TD children with high‐autistic traits relative to those with low‐autistic traits. IA was negatively correlated with autistic and ADHD symptoms. Atypical cardiac interoception could be found in children with ASD. Difficulties in sensing and comprehending internal bodily signals in childhood may be related to both ASD and ADHD symptoms.Lay SummaryThe present study examined interoceptive accuracy (IA) in children with autism spectrum disorders (ASD), children with comorbid ASD and attention‐deficit/hyperactivity disorder (ADHD), and typically developing (TD) children with high and low levels of autistic traits. ASD children with and without comorbid ADHD both exhibited lower IA than TD children. TD children with high‐autistic traits exhibited decreased IA compared to those with low‐autistic traits. These results have implications for understanding sensory atypicality found in ASD and ADHD.
Circular economy and resilience: A research agenda
Authors: Kennedy Steve , Linnenluecke Martina K. 
Published: January 2022

AbstractThe circular economy is argued to be a way of organising industrial systems that support resilience through decoupling economic growth from material consumption. Yet, extant research exploring the impacts of circular economy business practices on resilience is nascent, with few studies detailing if and how these practices enable firms, industries and social‐ecological systems to adapt and transform in the face of shocks and disturbances. In this article, we seek to advance research on the circular economy by proposing a research agenda that connects the circular economy to resilience at multiple levels. Based on insights from resilience theory and findings from the limited literature on the circular economy that has considered resilience to date, our research agenda focuses scholarly attention on key areas of congruence and contestation. We posit that pursuit of answers in these areas has the potential for advancing circular economy business practices capable of supporting resilience at multiple levels.
Biotransformation Enables Innovations Toward Green Synthesis of Steroidal Pharmaceuticals
Authors: Feng Jinhui , Wu Qiaqing , Zhu Dunming , Ma Yanhe 
Published: January 2022

AbstractSteroids have been widely used in birth‐control, prevention, and treatment of various diseases, representing the largest sector after antibiotics in the global pharmaceutical market. The steroidal active pharmaceutical ingredients (APIs) have been produced via partial synthetic processes first mainly from sapogenins, which was converted into 16‐dehydropregnenolone by the famous “Marker Degradation”. Traditional mutation and screening, and process engineering have resulted in the industrial production of 4‐androstene‐3,17‐dione (AD), androst‐1,4‐diene‐3,17‐dione (ADD), 9α‐hydroxy‐androsta‐4‐ene‐3,17‐dione (9α‐OH‐AD), and so on, which serve as the key intermediates for the synthesis of steroidal APIs. Recently, genetic and metabolic engineering have generated highly efficient microbial strains for the production of these precursors, leading to the replacement of sapogenins with phytosterols as the starting materials. Further advances in synthetic biology hold promise in the design and construction of microbial cell factories for the industrial production of steroidal intermediates and/or APIs from simple carbon sources such as glucose. Integration of biotransformation into the synthesis of steroidal APIs can greatly reduce the number of reaction steps, achieve lower waste discharge and higher production efficiency, thus enabling a greener steroidal pharmaceutical industry.
Advances of Ionic Liquids and Deep Eutectic Solvents in Green Processes of Biomass‐Derived 5‐Hydroxymethylfurfural
Authors: Chen Lifang , Xiong Yuhang , Qin Hao , Qi Zhiwen 
Published: January 2022

Abstract5‐Hydroxymethylfurfural (HMF) is identified as an important bio‐based platform chemical to bridge petroleum‐based and biomass‐based resources. It can be obtained through dehydration of various carbohydrates as well as converted to value‐added fuels and chemicals. As designer solvents, ionic liquids (ILs) and deep eutectic solvents (DESs) have been widely used in catalytic transformation of biomass derivatives to various chemicals. This Review summarizes recent progress in experimental and theoretical studies on dehydration of carbohydrates such as fructose, glucose, sucrose, cellobiose, chitosan, cellulose, inulin, and even raw biomass to generate HMF using ILs and DESs as catalysts/cocatalysts and/or solvents/cosolvents. It also gives an overview of IL and DES‐involved catalytic transformation of HMF to downstream products via oxidation, reduction, esterification, decarboxylation, and so forth. Challenges and prospects of ILs and DESs are also proposed for further production of HMF and HMF derivatives from biomass in green and sustainable processes.
Disruption of the pentraxin 3/CD44 interaction as an efficient therapy for triple‐negative breast cancers
Authors: Hsiao Yu‐Wei , Chi Jhih‐Ying , Li Chien‐Feng , Chen Lei‐Yi , Chen Yi‐Ting , Liang Hsin‐Yin , Lo Yu‐Chih , Hong Jhen‐Yi , Chuu Chin‐Pin , Hung Liang‐Yi , Du Jyun‐Yi , Chang Wen‐Chang , Wang Ju‐Ming 
Published: January 2022

AbstractDue to the heterogeneity and high frequency of genome mutations in cancer cells, targeting vital protumour factors found in stromal cells in the tumour microenvironment may represent an ideal strategy in cancer therapy. However, the regulation and mechanisms of potential targetable therapeutic candidates need to be investigated. An in vivo study demonstrated that loss of pentraxin 3 (PTX3) in stromal cells significantly decreased the metastasis and growth of cancer cells. Clinically, our results indicate that stromal PTX3 expression correlates with adverse prognostic features and is associated with worse survival outcomes in triple‐negative breast cancer (TNBC). We also found that transforming growth factor beta 1 (TGF‐β1) induces PTX3 expression by activating the transcription factor CCAAT/enhancer binding protein delta (CEBPD) in stromal fibroblasts. Following PTX3 stimulation, CD44, a PTX3 receptor, activates the downstream ERK1/2, AKT and NF‐κB pathways to specifically contribute to the metastasis/invasion and stemness of TNBC MDA‐MB‐231 cells. Two types of PTX3 inhibitors were developed to disrupt the PTX3/CD44 interaction and they showed a significant effect on attenuating growth and restricting the metastasis/invasion of MDA‐MB‐231 cells, suggesting that targeting the PTX3/CD44 interaction could be a new strategy for future TNBC therapies.
Diagnostics of Ne–Ar mixture plasma using a fine‐structure resolved collisional radiative model
Authors: Baghel Shubham S. , Gangwar Reetesh K. , Srivastava Rajesh 
Published: January 2022

AbstractA collisional radiative (CR) model has been developed for the diagnostics of Ne–Ar mixture plasma. The 40 fine‐structure resolved energy levels of neon corresponding 2p53s, 2p53p, 2p53d, 2p54s, and 2p54p along with ground state (2p6) and ion state (2p5) have been considered. All the essential population and de‐population channels viz. electron impact excitation‐de‐excitation, ionization, two/three‐body recombination, radiative decay, self‐absorption correction, diffusion, etc., have been considered in the model. The quenching of relatively higher lifetime states 2p53s due to interaction with Ar atoms through associative and Penning ionization is also included in the model. The applicability of the CR model is demonstrated by performing the optical diagnostic of rf induced inductively coupled Ne–Ar mixture plasma. The plasma parameters viz. electron temperature, electron density, and population distribution of levels at various mixture conditions are extracted by coupling the present CR model predictions with emission and absorption measurements by Boffard et al. [J. Phys. D: Appl. Phys., 45, 382001 (2012) and private communication]. The results are also compared with earlier optical models and Langmuir probe measurements. The self‐absorption correction (escape) factors and electron impact excitation rates at various Ne–Ar mixture concentrations are also presented.
Effect of interferon regulatory factor 2 on inflammatory response and oxidative stress in lipopolysaccharide‐induced acute kidney injury
Authors: He Tianwei , Yang Lina , Wu Daoxu 
Published: January 2022

AbstractInterferon regulatory factor (IRF) 2 plays an important role in lipopolysaccharide (LPS)‐induced acute kidney injury (AKI). In this study, we explored the effects of IRF2 on apoptosis, inflammation, and oxidative stress in AKI C57BL/6 male mouse model and HEK293 cells following LPS treatment. To determine the effect of IRF2, short hairpin RNAs in mice and small interfering RNAs in cells were used to knockdown IRF2 expression. IRF2 expression, apoptosis, and severity of inflammatory and oxidative stress in mice and cells were measured. IRF2 levels were upregulated in LPS‐treated mice and cells. IRF2 knockdown suppressed the levels of creatinine, blood urea nitrogen, and kidney injury molecule 1 and decreased the renal injury score in mice. Furthermore, IRF2 knockdown inhibited apoptosis and decreased the levels of inflammatory, reactive oxygen species (ROS), and malondialdehyde (MDA), but increased superoxide dismutase (SOD) levels in mice and cells. Furthermore, we found that the Janus kinase (JAK)/ signal transducer and activator of transcription pathway activated by LPS was inhibited by knockdown of IRF2, and enhanced by IRF2 overexpression. IRF2 overexpression increased cell apoptosis, inflammation, and ROS and MDA levels, and decreased SOD levels. However, the effect of IRF2 overexpression was reversed by the JAK inhibitor tofacitinib. Knockdown of IRF2 reduced LPS‐induced renal tissue injury in vivo and in vitro through anti‐inflammatory and antioxidant stress effects.