bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of supplementary inulin on ewes milk composition and rumen fermentation parameters
Authors: Paya Hamid , Giannenas Ilias , Taghizadeh Akbar , Hosseinkhani Ali , Palangi Valiollah , Hasanpur Karim , Ayasan Tugay , Montazerharzand Mehri , Shirmohammadi Shahram , Elmi Naser 
Published: August 2022

AbstractThis experiment aimed to investigate the effects of inulin supplementation on milk production and composition, feed intake, nutrient digestibility and rumen fermentation parameters in lactating ewes. The experimental treatments were (1) control group (basal diet), (2) basal diet plus 2% inulin (w/w) and (3) basal diet plus 4% inulin (w/w). The experiment was carried out for 21 d in a fully randomized design involving eighteen Ghezel ewes. Production and composition (percentages of fat, protein, lactose and fat-free solids and fatty acid profiles) of milk were measured. Faeces were collected in the last 3 days of the experiment to determine digestibility. On the last day of the experiment, rumen fluid samples were taken from the esophagus 3 h after feeding and fermentation parameters (pH, ammonia nitrogen (N-NH3), volatile fatty acids (VFA) and protozoal population) were examined. Daily milk production was not significantly affected by inulin supplementation, but the fat and protein content of the milk was increased whilst urea nitrogen (MUN) and unsaturated fatty acids were decreased (P < 0.05). The dry matter (DM) intake results showed that there was no significant difference between different diets. The highest digestibility of DM and NDF belonged to the inulin fed group (P < 0.05). Inulin consumption numerically increased the pH of the rumen fluid of the animals and significantly decreased the rumen N-NH3 value (P < 0.05). Inulin supplementation also significantly increased total VFA, acetate, and butyrate levels (P < 0.05). In general, it can be concluded that inulin supplementation can improve rumen fermentation, DM and NDF digestibility,as well as compositional aspects of the ewe's milk production.
Associations between cow-level parameters and heart rate variability as a marker of the physiological stress response in dairy cows
Authors: Frei Andrea , Evans Neil P. , King George , McAloon Conor G. , Viora Lorenzo 
Published: August 2022

AbstractTo maintain and enhance cow productivity and welfare, it is important that we can accurately assess and understand how cows respond to the physiological demands of gestation and lactation. Several methods have been developed for assessing the physiological responses to stressors and for detecting distress in cattle. Heart rate (HR) variability (HRV) is a non-invasive measure of autonomic nervous system activity and consequently a component of the physiological response to stress. In cattle, HRV has been successfully used to measure autonomic responses to a variety of health conditions and management procedures. The objectives of this study were to determine whether, among commercial Holstein Friesian cows and across farms, relationships exist between cow-level factors, HR and HRV. HRV parameters were compared with production records for 170 randomly selected, Holstein-Friesian-cows on 3 commercial dairy farms. Production data included parity, days in milk (DIM), milk yield, somatic cell count (SCC), % butterfat and protein, body condition score (BCS) and genetic indices. Fixed-effect, multivariable linear regression models were constructed to examine the association between cow-level variables and HRV parameters. Statistically significant relationships were found between HR and farm, temperature and BCS, and between HRV parameters and farm, rectal temperature, BCS, DIM, and percentage butterfat. Given the significant association between farms and several of the indices measured, it is recommended that care must be taken in the interpretation of HRV studies that are conducted on animals from a single farm. The current study indicated that within clinically normal dairy cattle HRV differed with the percentage of butterfat and BCS. Based on the relationships reported previously between HRV and stress in dairy cattle these results suggest that stress may be increased early in lactation, in cows with BCS <2.75 that are producing a high percentage of butterfat milk. Future work could focus on the physiological mechanisms through which these factors and their interactions alter HRV and how such physiological stress may be managed within a commercial farm setting.
Remorse and the Ledger Theory of Meaning
Authors: Scripter Lucas 
Published: August 2022

AbstractA common idea about assessing meaning in life is that one draws up a list of those various positive values that one has achieved and subtracts from it one's negative deeds in life. The resulting balance is the meaningfulness of one's existence. I call this the ledger theory. Drawing on the work of Raimond Gaita and Julian Barnes's novel The Sense of an Ending, I argue for a phenomenology of remorse that gives us reason to reject the ledger theory. Even those agents whose lives have been exceptionally meaningful in some respects may remain haunted by their past. Certain sorts of misdeeds – those that involve significant, irreparable damage – leave life marred in such a way that the negative remains, even in the face of all the meaningful deeds of life.
Designing daily-life research combining experience sampling method with parallel data
Authors: De Calheiros Velozo Joana , Habets Jeroen , George Sandip V. , Niemeijer Koen , Minaeva Olga , Hagemann Noëmi , Herff Christian , Kuppens Peter , Rintala Aki , Vaessen Thomas , Riese Harriëtte , Delespaul Philippe 
Published: August 2022

AbstractBackgroundAmbulatory monitoring is gaining popularity in mental and somatic health care to capture an individual's wellbeing or treatment course in daily-life. Experience sampling method collects subjective time-series data of patients' experiences, behavior, and context. At the same time, digital devices allow for less intrusive collection of more objective time-series data with higher sampling frequencies and for prolonged sampling periods. We refer to these data as parallel data. Combining these two data types holds the promise to revolutionize health care. However, existing ambulatory monitoring guidelines are too specific to each data type, and lack overall directions on how to effectively combine them.MethodsLiterature and expert opinions were integrated to formulate relevant guiding principles.ResultsExperience sampling and parallel data must be approached as one holistic time series right from the start, at the study design stage. The fluctuation pattern and volatility of the different variables of interest must be well understood to ensure that these data are compatible. Data have to be collected and operationalized in a manner that the minimal common denominator is able to answer the research question with regard to temporal and disease severity resolution. Furthermore, recommendations are provided for device selection, data management, and analysis. Open science practices are also highlighted throughout. Finally, we provide a practical checklist with the delineated considerations and an open-source example demonstrating how to apply it.ConclusionsThe provided considerations aim to structure and support researchers as they undertake the new challenges presented by this exciting multidisciplinary research field.
‘We come from the underground’: grounding Chinese punk in Beijing and Wuhan
Authors: Amar Nathanel 
Published: August 2022

AbstractThe history of the Chinese punk scene in the scientific literature or in retrospective testimonies is traditionally dominated by a Beijing-centric approach, which stresses the importance of Beijing punk bands in the 1990s for the formation of this youth subculture. However, at the same time another punk scene was emerging in Wuhan, and no convincing argument has been provided to explain how, at the same time, in two Chinese cities, a punk movement appeared. Relying on ethnographic fieldwork, interviews and collection of data, this article aims to explain how in the mid-1990s young Chinese succeeded into territorialising a foreign subculture in two different Chinese cities.
Harm, Failing to Benefit, and the Counterfactual Comparative Account
Authors: Klocksiem Justin 
Published: August 2022

AbstractIn the literature about harm, the counterfactual comparative account has emerged as a main contender. According to it, an event constitutes a harm for someone iff the person is worse off than they would otherwise have been as a result. But the counterfactual comparative account faces significant challenges, one of the most serious of which stems from examples involving non-harmful omitted actions or non-occurring events, which it tends to misclassify as harms: for example, Robin is worse off when Batman does not give him a new set of golf clubs, but Batman has not harmed him. In this article, I will clearly state the counterfactual comparative account; state and explain this objection to the account; canvass several unsatisfactory responses; and attempt to show how the account can overcome the objection. This solution involves distinguishing between principles concerning the existence of harm and principles concerning attributions of responsibility for harm.
Children’s neural reactivity to maternal praise and criticism: Associations with early depressive symptoms and maternal depression
Authors: Vandermeer Matthew R.J. , Liu Pan , Mohamed Ali Ola , Daoust Andrew R. , Joanisse Marc F. , Barch Deanna M. , Hayden Elizabeth P. 
Published: August 2022

AbstractCaregiving experiences are implicated in children’s depression risk; however, children’s neural reactivity to positive and negative feedback from mothers, a potential mediator of depression risk, is poorly understood. In a sample of 81 children (Mage = 11.12 years, SDage = 0.63), some of whom were recruited based on a maternal history of depression (n = 29), we used fMRI to characterize children’s neural responses to maternal praise and criticism. Maternal history of depression was unrelated to children’s brain activity during both the praise and criticism conditions; however, ROI analyses showed that children’s self-reported depressive symptoms were negatively associated with functional activity in the left anterior insula and right putamen while hearing maternal criticism. Whole-brain analyses showed that children’s depressive symptoms were positively associated with left inferior frontal gyrus activity while listening to maternal praise. These findings complement past work implicating these brain regions in the processing of emotionally salient stimuli, reward processing, and internal speech. Given associations between early depressive symptoms and later disorder, findings suggest that maladaptive neural processing of maternal feedback may contribute to children’s early emerging risk for depression.
Gene-environment interplays between family chaos and emotional problems among Nigerian adolescents: A twin study
Authors: Oginni Olakunle A. , Hur Yoon-Mi 
Published: August 2022

AbstractGene-environment correlations and interactions for the relationship between emotional problems (EP) and family environment in adolescents in low- to middle-income countries (LMIC) have been rarely investigated. In total, 3207 adolescent twins aged 12–18 (Mean = 14.6 ± 1.73) years attending public schools in Lagos State in Nigeria completed measures of EP and Family Chaos (FC). Model-fitting analyses suggested that genetic and non-shared environmental influences on EP were 21% and 71%, respectively, and the corresponding estimates were 23% and 71% for FC. Shared environmental influences were not significant (8% and 6% respectively). Phenotypic correlation between EP and FC was .30 (95% CI = .27–.34), which was significantly influenced by genetic (A – 49%, 95% CI: 0.01–0.97) and non-shared environmental factors (E – 32%, 95% CI: 0.10–0.54). Shared environmental influences were not significant (C – 19%, 95% CI: −0.13 to 0.50). Moderation effects were significant whereby as FC increased, A on EP decreased (βA = −0.07, 95% CI: −0.12 to −0.02) while E increased (βE = 0.06, 95% CI: 0.03–0.09). Our findings indicate that genetic and non-shared environmental risk factors may mediate the relationship between EP and FC, and that as FC increases, protective genetic influences on EP may be attenuated, whereas environmental influences may become stronger in adolescents in LMIC.
Single stage biventricular repair of hypoplastic right ventricle with straddling tricuspid valve
Authors: Prabhu Neel K. , Zhu Alexander , Turek Joseph W. , Andersen Nicholas D. 
Published: August 2022

AbstractWe present the case of a five-year-old child with an inlet ventricular septal defect, subpulmonic stenosis, hypoplastic right ventricle, and straddling tricuspid valve who received a successful one-stage biventricular repair with right ventricular rehabilitation, right ventricular outflow tract augmentation, papillary muscle transposition, ventricular septal defect closure, and fenestrated atrial septation. This report outlines the surgical decision making and operative technique.
Automated modeling of protein accumulation at DNA damage sites using qFADD.py
Authors: Bowerman Samuel , Mahadevan Jyothi , Benson Philip , Rudolph Johannes , Luger Karolin 
Published: August 2022

Abstract
Eukaryotic cells are constantly subject to DNA damage, often with detrimental consequences for the health of the organism. Cells mitigate this DNA damage through a variety of repair pathways involving a diverse and large number of different proteins. To better understand the cellular response to DNA damage, one needs accurate measurements of the accumulation, retention, and dissipation timescales of these repair proteins. Here, we describe an automated implementation of the “quantitation of fluorescence accumulation after DNA damage” method that greatly enhances the analysis and quantitation of the widely used technique known as laser microirradiation, which is used to study the recruitment of DNA repair proteins to sites of DNA damage. This open-source implementation (“qFADD.py”) is available as a stand-alone software package that can be run on laptops or computer clusters. Our implementation includes corrections for nuclear drift, an automated grid search for the model of a best fit, and the ability to model both horizontal striping and speckle experiments. To improve statistical rigor, the grid-search algorithm also includes automated simulation of replicates. As a practical example, we present and discuss the recruitment dynamics of the early responder PARP1 to DNA damage sites.
Probabilistic Predictions of Ecologically Relevant Hydrologic Indices Using a Hydrological Model
Authors: Hernandez‐Suarez J. Sebastian , Nejadhashemi A. Pouyan 
Published: August 2022

AbstractThis study evaluated the effects of prior knowledge obtained from multi‐objective optimization on the uncertainty quantification of simulated ecologically relevant hydrologic indices (ERHIs) using a hydrological model. Two experiments were formulated considering contrasting conditions in prior knowledge when implementing Bayesian parameter estimation. In the first experiment, we reproduced a common modeling practice in the absence of previous information where uniform priors are considered when calibrating hydrological and error model parameters. In the second experiment, near‐optimal Pareto solutions from multi‐objective calibration were used to build a multivariate prior distribution for estimating hydrological and error model parameters using Bayesian calibration. In both experiments, a likelihood function considering heteroscedasticity and autocorrelation effects was employed. The Unified Non‐dominated Sorting Algorithm III was used for multi‐objective calibration, whereas the multiple‐try differential evolution adaptive metropolis algorithm was used for Markov Chain Monte Carlo sampling. The experiments were tested using a hydrologic model. We selected a subset of ERHIs comprised of 32 central tendency Indicators of Hydrologic Alteration and seven additional indices describing basic streamflow statistical properties. In general, using near‐optimal Pareto parameter distributions as prior knowledge in Bayesian calibration reduced both the bias and variability ranges in ERHIs prediction. Furthermore, there was no significant loss in the reliability of streamflow predictions (from 2% to 6%, p = 0.07) when targeting the selected ERHIs, while improving precision (from 66% to 58%, p < 0.05) and reducing the bias (from 6% to 4%, p < 0.05). Moreover, parametric uncertainty substantially shrank by 72% when linking multi‐objective calibration and Bayesian parameter estimation.
Sustainable Development Pathways for Chinese Cities: An Assessment of the Advanced Inclusive Wealth Index
Authors: Xue Qianyu , Cheng Danyang , Li Yuan , Guan Dabo , Zhao Weichen 
Published: August 2022

AbstractThe inclusive wealth index (IWI) is a stock metric proposed internationally in recent years to measure a region's sustainable development potential. To explore sustainability more comprehensively in this context, this paper improves the inclusive wealth (IW) system proposed by the United Nations Environment Programme by extending the definition of intangible capital and refining the classification of different types of capital. We then used the advanced IWI to investigate the changes in per capita IW and its capital composition in China's 10 National Sustainable Development Agenda Innovation Demonstration Zones from 2010 to 2019, and proposed sustainable development pathways for Chinese cities. Our results underline the fact that IW and capital structure across different types of cities is highly variable. The growth of IW per capita in Shenzhen, an international metropolis, mainly depends on advanced produced capital and intangible capital. For Ordos, however—a resource‐rich “energy city”—the per capita IW is driven by ordinary produced capital and restricted by non‐renewable natural capital, thus showing a low level of sustainability. Through its consideration of four kinds of capital, this study also points out the inequality of human capital between urban‐rural and male‐female groups, and demonstrates how increasing educational attainment helps to promote the transfer of human capital between regions and sectors. In general, a strong potential for sustainable development is linked to the promotion of highly educated human capital, advanced produced capital and intangible capital, while the ecosystem service value of natural capital is also key.
Atmospheric Rivers Contribute to Summer Surface Buoyancy Forcing in the Atlantic Sector of the Southern Ocean
Authors: Edholm Johan M. , Swart Sebastiaan , Plessis Marcel D. , Nicholson Sarah‐Anne 
Published: August 2022

AbstractAtmospheric rivers (ARs) dominate moisture transport globally; however, it is unknown what impact ARs have on surface ocean buoyancy. This study explores the surface buoyancy gained by ARs using high‐resolution surface observations from a Wave Glider deployed in the subpolar Southern Ocean (54°S, 0°E) between 19 December 2018 and 12 February 2019 (55 days). When ARs combine with storms, the associated precipitation is significantly enhanced (189%). In addition, the daily accumulation of AR‐induced precipitation provides a buoyancy gain to the surface ocean equivalent to warming by surface heat fluxes. Over the 55 days, ARs accounted for 47% of the total precipitation equating to 10% of the summer surface ocean buoyancy gain. This study indicates that ARs play an important role in the summer precipitation over the subpolar Southern Ocean and that they can alter the upper‐ocean buoyancy budget from synoptic to seasonal timescales.
Dynamical Complexity Response in Traveling Ionospheric Disturbances Across Eastern Africa Sector During Geomagnetic Storms Using Neural Network Entropy
Authors: Oludehinwa I. A. , Velichko A. , Ogunsua B. O. , Olusola O. I. , Odeyemi O. O. , Njah A. N. , Ologun O. T. 
Published: August 2022

AbstractThis paper examines the response of dynamical complexity in traveling ionospheric disturbances (TIDs) across Eastern Africa sector during major geomagnetic storms. Detrended total electron content derived from eight stations of Global Positioning System receivers across Eastern Africa was used to unveil the transient features of dynamical complexity response in TIDs. Neural network entropy (NNetEn) was applied to the detrended TEC time series data to capture the degree of dynamical complexity. The NNetEn track the distinct features associated with the occurrence of TIDs. The results show that as the signatures of TIDs begin to emerge, low values of NNetEn signifying reduction in the degree of dynamical complexity response were observed while high values of NNetEn were depicted as the signatures of TIDs subsides signifying increase in the dynamical complexity response. Reduction in dynamical complexity response associated with the occurrence of TIDs is more evident in the Southern Hemisphere compared to Northern Hemisphere. Furthermore, we found that the propagation of TIDs is more prominent at Equinoctial season compared to solstitial season. The latitudinal observation of NNetEn revealed higher degree of dynamical complexity response in ADIS and NEGE signifying that the development of TIDs is minimal in ADIS and NEGE. Finally, the reduction in dynamical complexity associated with the occurrence of TIDs were obvious during all the phases of geomagnetic storms. In particular, the dynamical complexity response at initial and recovery phases of geomagnetic storm depicts more TIDs features.
Integrated relationship of nasopharyngeal airway host response and microbiome associates with bronchiolitis severity
Authors: Fujiogi Michimasa , Raita Yoshihiko , Pérez-Losada Marcos , Freishtat Robert J. , Celedón Juan C. , Mansbach Jonathan M. , Piedra Pedro A. , Zhu Zhaozhong , Camargo Carlos A. , Hasegawa Kohei 
Published: August 2022

AbstractBronchiolitis is a leading cause of infant hospitalizations but its immunopathology remains poorly understood. Here we present data from 244 infants hospitalized with bronchiolitis in a multicenter prospective study, assessing the host response (transcriptome), microbial composition, and microbial function (metatranscriptome) in the nasopharyngeal airway, and associate them with disease severity. We investigate individual associations with disease severity identify host response, microbial taxonomical, and microbial functional modules by network analyses. We also determine the integrated relationship of these modules with severity. Several modules are significantly associated with risks of positive pressure ventilation use, including the host-type I interferon, neutrophil/interleukin-1, T cell regulation, microbial-branched-chain amino acid metabolism, and nicotinamide adenine dinucleotide hydrogen modules. Taken together, we show complex interplays between host and microbiome, and their contribution to disease severity.