bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Geriatric Emergency Department post‐discharge referral order and follow‐up with healthcare utilization
Authors: Simpson Michelle , Sergi Clinton , Malsch Aaron , Ryer Suzanne , Rubach Christopher , Singh Maharaj 
Published: December 2022

AbstractBackgroundCompared with younger adults who receive care in the emergency department (ED), older patients who are discharged home have greater risk of adverse health outcomes. Connecting older adults with outpatient care following ED discharge are among the guidelines of the Geriatric Emergency Department (GED). The objective of this study was to examine the association between referral order placed during the ED visit for older adults and post‐discharge follow‐up to the outcomes of 72‐h ED revisit, 30‐day ED revisit, and 30‐day all cause and unplanned hospital admission.MethodsWe conducted a retrospective cohort study. Ten accredited GEDs within one midwestern health system and all ED encounters of older adults aged 65 years and older who were discharged home from the ED between July 2019 and December 2020 were included. Predictor variables included age, sex, race, ISAR©, ED Length of Stay, post‐ED referral order, and follow‐up.ResultsAmong the older adults discharged home from the ED, 17% of older adult encounters had an outpatient referral ordered in the ED, 48.4% attended a follow‐up appointment. Referrals were ordered for 69 referral order types with orthopedic, family practice, and urology referrals as the top 3. In mixed‐effect regression models, compared with older adults with follow‐up, those with a referral order but no follow‐up had 19% higher odds of having a 30‐day ED revisit (OR = 1.19; 95% CI = 1.07–1.31) and 11% higher odds of having 30‐day unplanned hospital admission (OR = 1.11; 95% CI = 0.98–1.26).ConclusionsOlder adults who had an outpatient referral ordered prior to ED discharge and followed up had lower odds of a 30‐day ED revisit and 30‐day subsequent unplanned hospital admission. However, less than half of patients with a referral order attended a follow‐up appointment. Designing interventions for older adults aimed at improving follow‐up after an ED visit is needed.
Barriers to and recommendations for integrating the age‐friendly 4‐Ms framework into electronic health records
Authors: Southerland Lauren T. , Presley Carolyn J. , Hunold Katherine M. , Caterino Jeffrey M. , Collins Courtney E. , Walker Daniel M. 
Published: December 2022

AbstractBackgroundThe Institute for Healthcare Improvement's 4‐Ms framework of care for older adults recommends a multidisciplinary assessment of a patient's Medications, Mentation, Mobility, and What Matters Most. Electronic health record (EHR) systems were developed prior to this emphasis on the 4‐Ms. We sought to understand how healthcare providers across the healthcare system perceive their EHRs and to identify any current best practices and ideas for improvement regarding integration of the 4‐Ms.MethodsAnonymous survey of healthcare providers who care for older adults. The survey aimed to evaluate efficiency, error tolerance, and satisfaction (usefulness and likeability). The survey was distributed through organizational list serves that focus on the care of older adults and through social media.ResultsSixty‐six respondents from all geographic segments of the U.S. (n = 62) and non‐U.S. practices (n = 4) responded. Most (82%) were physicians. Respondents used a range of EHRs and 82% had >5 years of experience with their current EHR. Over half of respondents agreed that their EHR had easy to find contact information (56%) and advance directives. Finding a patient's prior cognitive status (26% agreement), goals of care (24%), functional status (14%), and multidisciplinary geriatric assessments (27%) was more difficult. Only 3% were satisfied with how their EHR handles geriatric syndromes. In free text responses, respondents (79%) described three areas that the EHR assists in the care of older adults: screening tied to actions or orders; advance care planning, and medication alerts or review. Common suggestions on how to improve the EHR included incorporating geriatric assessments in notes, establishing a unified place to review the 4‐Ms, and creating age‐specific best practice alerts.ConclusionsThe majority of healthcare providers were not satisfied with how their EHR handles multidisciplinary geriatric assessment and geriatric care. EHR modifications would aide in reporting, communicating, and tracking the 4‐Ms in EHRs.
The impact of nursing on health outcomes of people receiving medication for opioid use disorder: An integrative review
Authors: Alexander Karen , Smith Jamie M. , Gerolamo Angela , Bernhardt Jean 
Published: December 2022

AbstractIntroductionThis integrative review aimed to understand the impact of nursing on the health outcomes of people with opioid use disorder (OUD).MethodsWhittemore and Knafl's (2005) integrative review methodology guided the review process. The authors searched PubMed, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), and OVID databases for peer‐reviewed, English language articles describing nursing care for people receiving medications for OUD. The literature search followed the Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA) guidelines.ResultsA total of 773 articles were identified through the database searches after duplicates were removed; 15 articles met inclusion criteria and were included in the final review from the United States, Canada, Ireland, England, and the Netherlands. Two themes emerged: (1) The effect of nurse‐led care on patient outcomes and (2) Nursing roles and the environment of care. Studies emphasized the aspects of nursing care that promote patient‐centeredness and patient satisfaction.ConclusionsThe importance of the registered nurse in providing quality care for people receiving medications for OUD is clear from the literature reviewed. The studies in the review highlighted important aspects of the registered nurses' role in affecting outcomes for people receiving medications for OUD including communication and care coordination.Clinical relevanceThis review highlights the need for role delineation and further development of nurse‐sensitive indicators in the OUD treatment setting.
Introduction and overview of radiofrequency treatments in aesthetic dermatology
Authors: Delgado Axel R. , Chapas Anne 
Published: December 2022

AbstractIn this introductory article to this special supplement in radiofrequency (RF), we aim to summarize the scientific foundation of RF therapy and its role in aesthetic dermatology. Monopolar, bipolar, and multipolar RF systems are described in detail, along with the different delivery methods such as stamping, dynamic or continuous movement, fractional, fractionated (FR) needling, and non‐contact devices as well as the minimally invasive platforms that use subdermal probes. The characteristics of different tissues and the technical parameters that influence the effect of RF therapy, such as the penetration of energy, are summarized. This article expands on the various treatment applications for these devices and the mechanism of action behind skin and adipose tissue remodeling, and also discussed are safety concerns, treatment endpoints, and specific considerations when using RF therapy to provide effective treatment outcomes with reduced patient downtime.
Reviewing the employee spinout literature: A cross‐disciplinary approach
Authors: Yeganegi Sepideh , Dass Parshotam , Laplume André O. 
Published: December 2022

AbstractIncreasing research on spinouts highlights the key role that employees play in new business creation, knowledge diffusion, and economic development. However, this research conflicts on many points, including on definitions of key concepts. In this paper, we review the theoretical and empirical literatures on private sector employee spinouts and integrate insights spanning multiple academic disciplines. We address definitional ambiguity and propose a cross‐disciplinary conceptual framework that adequately captures the extant literature on this phenomenon. Doing so allows us to organize the selected academic articles on employee spinouts into six themes: antecedents at the individual, organizational (parent firm), and external environmental levels, and consequences of spinouts for spinout founder(s), parent firms, and external environments. For each theme, we summarize the key research questions, theories, and evidence to date, and refer to potential integration points that could help to expand our knowledge. We conclude our review of each major theme with targeted suggestions for future research.
Cerebral cavernous malformations: Typical and atypical imaging characteristics
Authors: Kuroedov Danila , Cunha Bruno , Pamplona Jaime , Castillo Mauricio , Ramalho Joana 
Published: December 2022

AbstractCavernous malformations (CMs) are benign vascular malformations that maybe seen anywhere in the central nervous system. They are dynamic lesions, growing or shrinking over time and only rarely remaining stable. Size varies from a few millimeters to a few centimeters. CMs can be sporadic or familial, and while most of them are congenital, de novo and acquired lesions may also be seen. Etiology is still unknown. A genetic molecular mechanism has been proposed since a cerebral cavernous malformation gene loss of function was found in both familial and sporadic lesions. Additionally, recent studies suggest that formation of CMs in humans may be associated with a distinctive bacterial gut composition (microbioma). Imaging is fairly typical but may vary according to age, location, and etiology. Follow‐up is not well established because CMs patients have a highly unpredictable clinical course. Angiogenic and inflammatory mechanisms have been implicated in disease activity, as well as lesional hyperpermeability and iron deposition. Imaging and serum biomarkers of these mechanisms are under current investigation. Treatment options, including surgery or radiosurgery, are not well defined and are dependent upon multiple factors, including clinical presentation, lesion location, number of hemorrhagic events, and medical comorbidities. Our purpose is to review the imaging features of CMs based on their size, location, and etiology, as well as their differential diagnosis and best imaging approach. New insights in etiology will be briefly considered. Follow‐up strategies, including serum and imaging biomarkers, and treatment options will also be discussed.
World Workshop on Oral Medicine VII: Oral adverse effects to biologic agents in patients with inflammatory disorders. A scoping review
Authors: France Katherine , Yogarajah Sangeetha , Gueiros Luiz Alcino , Valdez Remberto , Mays Jacqueline W. , Posey Rachael , Payne Aimee S. , Setterfield Jane , Sollecito Thomas P. , Woo Sook‐Bin , DeRossi Scott , Greenberg Martin S. , Carey Barbara 
Published: December 2022

AbstractBackgroundBiologic agents are rapidly emerging as an effective therapy to treat autoimmune and other chronic diseases. The use of these agents is poorly characterized, resulting in a lack of guidance for dental practitioners. Case reports of oral adverse events have begun to emerge. However, their scope and frequency have not been summarized and analysed to date. The objective of this review was to characterize the literature on oral adverse effects associated with biological therapy when used for autoimmune and inflammatory disorders.MethodsThis review was developed in accordance with scoping review recommendations. Search strategies were developed and employed for six databases. Studies were selected using a systematic search process but with broad inclusion of study types given the paucity of information available. Reports of oral adverse events were analysed descriptively according to agent, mechanism of action, underlying disease, and oral adverse effect observed.ResultsOur search returned 2080 articles and 51 met our inclusion criteria, of which most were case reports. The most frequent adverse effects included angioedema, oral lichenoid lesions, osteonecrosis of the jaw, and oral infections. There were also cases of oral malignancies associated with use of biologic agents. Less common effects such as pigmentation were also described.ConclusionsOral adverse events have been reported in patients on biologic therapy, albeit in small numbers to date. This limits the generalizability of these results, which should not be used to generate a clinical guideline as they are based primarily on case reports. However, this study presents the first review characterizing the adverse effects observed. Large multi‐center studies will be necessary to further define the oral and dental complications caused by biologic agents.
Developing a different voice: The life and work of Carol Gilligan
Authors: Josselson Ruthellen 
Published: December 2022

AbstractObjectiveTo explore the psychobiographical origins of Carol Gilligan's sensitivity to the importance of voice in human psychology, an awareness that, through her foundational written work, transformed the field.MethodNarrative inquiry and analysis.ResultsCarol Gilligan's awareness of voice began at a young age with a self‐defining memory in which she learned to hold on to her own voice and experience. She never set out to be a social change agent, but she became one. Other scholars relied on her work, particularly the lyrical trope of “in a different voice” to change social (and psychological) attitudes toward women in many ways. This psychobiographical analysis traces Carol's personal struggles to sustain her own voice and knowledge, and these struggles met a culture that became able to hear something about how the patriarchal culture suppresses relational sensibilities. Rooted in a close and intense relationship with her mother, who expressed and imposed on her a duality between the voice of personal experience and the voice of meeting social expectations. Carol's understanding of the differing levels of what it means “to know” grounded a new conception of girls' development as well as of moral development.ConclusionCarol Gilligan became an agent of social change because her inner world and life path coincided with sociocultural readiness to embrace her work as giving voice to an emerging awareness of the suppression and denigration of women's sensibilities in psychology as well as in the larger culture. Her lifelong conflicts about speaking her own truth versus conforming to a society in which she was well able to be successful attuned her to the ways in which others, particularly women, similarly discounted their own experience.
Young adults' taste perception, consumption habits, and how this influences their willingness to pay for wine: Evidence from an experimental auction
Authors: Jorge Eloi 
Published: December 2022

AbstractThe main purpose of the present study is to investigate whether consumers' taste perception and wine consumption habits lead to different buying behaviors regarding consumers' willingness to pay for a bottle of wine. For this purpose, this research employs an empirical evaluation using an experimental auction, along with the self‐administration of a questionnaire, involving a sample of young adult students (n = 80) from a Spanish public university. In the experiment, we test four wines of the same region with different characteristics. A standard confirmatory partial least square–structural equation modeling was used for measurement and validation. The findings show that although consumers' buying behavior could be driven by either intrinsic (i.e., sensory perceptions) or visual (i.e., certifications) cues, consumers' taste perception or wine consumption habits lead them to react differently to these cues. By considering possible on‐trade and off‐trade scenarios in the same study, this study takes a fresh and more comprehensive look at young adults' willingness to pay for a bottle of wine. Overall, the study attests to the importance of a previous sensory experience for these consumers, identified as having a low degree of involvement with wine, and concludes that some extrinsic cues can be overestimated concerning taste expectations. The evidence obtained by using quantitative methods found a reliable insight that practitioners and administrators can implement to develop and adopt effective policy interventions.Practical ApplicationsConsumers' willingness to pay for wine is based on sensorial aspects or having information to support the decision. The main purpose of the present study is to investigate whether consumers' taste perception and wine consumption habits lead to different buying behaviors regarding consumers' willingness to pay for a bottle of wine.
Spiritual exercises and poetry: Pierre Hadot and Du Fu
Authors: Harte Ryan 
Published: December 2022

AbstractThis paper discusses poetry as a site of what Pierre Hadot calls “spiritual exercises,” with particular reference to China's greatest poet, Du Fu (712–70 C.E.). While Hadot's work has bridged gaps between (i) philosophy and religion and (ii) theory and practice, this paper suggests that spiritual exercises can also blur the modern separation between form and content. It argues for the possibility of poetry as philosophy; that is, philosophy in a less‐recognized form. If poetry can be spiritual exercise and if spiritual exercise with its goal of self‐transformation is the core of philosophy, then we may be able to treat poetry as one form of philosophy. The paper also demonstrates the relevance of Hadot's work for ancient Chinese and comparative philosophy more broadly.
Artificial intelligence facilitates measuring reflux episodes and postreflux swallow‐induced peristaltic wave index from impedance‐pH studies in patients with reflux disease
Authors: Wong Ming‐Wun , Liu Min‐Xiang , Lei Wei‐Yi , Liu Tso‐Tsai , Yi Chih‐Hsun , Hung Jui‐Sheng , Liang Shu‐Wei , Lin Lin , Tseng Chiu‐Wang , Wang Jen‐Hung , Wu Ping‐An , Chen Chien‐Lin 
Published: December 2022

AbstractBackground/AimReflux episodes and postreflux swallow‐induced peristaltic wave (PSPW) index are useful impedance parameters that can augment the diagnosis of gastroesophageal reflux disease (GERD). However, manual analysis of pH‐impedance tracings is time consuming, resulting in limited use of these novel impedance metrics. This study aims to evaluate whether a supervised learning artificial intelligence (AI) model is useful to identify reflux episodes and PSPW index.MethodsConsecutive patients underwent 24‐h impedance‐pH monitoring were enrolled for analysis. Multiple AI and machine learning with a deep residual net model for image recognition were explored based on manual interpretation of reflux episodes and PSPW according to criteria from the Wingate Consensus. Intraclass correlation coefficients (ICCs) were used to measure the strength of inter‐rater agreement of data between manual and AI interpretations.ResultsWe analyzed 106 eligible patients with 7939 impedance events, of whom 38 patients with pathological acid exposure time (AET) and 68 patients with physiological AET. On the manual interpretation, patients with pathological AET had more reflux episodes and lower PSPW index than those with physiological AET. Overall accuracy of AI identification for reflux episodes and PSPW achieved 87% and 82%, respectively. Inter‐rater agreements between AI and manual interpretations achieved excellent for individual numbers of reflux episodes and PSPW index (ICC = 0.965 and ICC = 0.921).ConclusionsAI has the potential to accurately and efficiently measure impedance metrics including reflux episodes and PSPW index. AI can be a reliable adjunct for measuring novel impedance metrics for GERD in the near future.
Inborn errors of immunity associated with defects of self‐tolerance checkpoints: The CD28 family
Authors: Rush‐Kittle Jorrell , Gámez‐Díaz Laura , Grimbacher Bodo 
Published: December 2022

AbstractOne of the causes of inborn errors of immunity is immune dysregulation. The inability of the immune system to regulate the extent of its activity has several deleterious effects, including autoimmunity, recurrent infections, and malignancy. In recent years, many proteins in the CD28 family – CD28, ICOS, CTLA‐4, PD‐1, and BTLA – have come into the focus of several research areas for their consequential role in the upregulation or downregulation of the immune response. In this review, we will discuss the structure and function of these proteins, as well as provide an overview of the clinical picture of patients with genetic defects.
Environment‐sensitive genic male sterility in rice and other plants
Authors: Peng Guoqing , Liu Zhenlan , Zhuang Chuxiong , Zhou Hai 
Published: December 2022

AbstractEnvironment‐sensitive genic male sterility is a type of male sterility that is affected by both genetic and environmental factors. Environment‐sensitive genic male sterile lines are not only used in two‐line hybrid breeding but are also good materials for studying plant−environment interactions. In this study we review the research progress on environment‐sensitive genic male sterility in rice from the perspectives of epigenetic, transcriptional, posttranscriptional, posttranslational and metabolic mechanisms as well as signal transduction processes. While significant progress has been made in the genetics, gene cloning and understanding of the molecular mechanisms of environment‐sensitive genic male sterility in recent years, the relevant regulatory network is still poorly understood in rice. We therefore also review studies of environment‐sensitive genic male sterility in Arabidopsis and other crops, hoping to promote research in this field in rice. Finally, we analyse the challenges posed by environment‐sensitive genic male sterility and provide corresponding suggestions. This review will contribute towards an understanding the molecular genetics of environment‐sensitive genic male sterility and its application in two‐line hybrid breeding in rice and other species.
A Jurassic volcanic passive margin in Iran and Turkey
Authors: Azizi Hossein , Stern Robert J. , Kandemir Raif , Karsli Orhan 
Published: December 2022

AbstractBroadly similar Early to Middle Jurassic stratigraphic sequences including bimodal igneous rocks of the Sanandaj–Sirjan Zone of Iran and the Sakarya Zone of Turkey suggest that these formed in a common tectonic setting in an extensional basin that evolved from a terrestrial magmatic rift to a marine shelf and passive continental margin. Whole‐rock chemistry and Sr–Nd isotope signatures indicate derivation of mafic melts from partial melting of the subcontinental lithosphere. Decompression associated with extension led to 5%–30% partial melting of spinel–garnet lherzolite with minor involvement of continental crust, producing tholeiitic to transitional basaltic magma. Extensional basins inverted during the Mid‐Late Jurassic. These relationships suggest the Early to Middle Jurassic formation of a volcanic rifted margin on the SW Eurasian margin, similar to that of offshore Norway.