bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective biosynthesis of retinol in S. cerevisiae
Authors: Hu Qiongyue , Zhang Tanglei , Yu Hongwei , Ye Lidan 
Published: March 2022

AbstractThe vitamin A component retinol has become an increasingly sought-after cosmetic ingredient. In previous efforts for microbial biosynthesis of vitamin A, a mixture of retinoids was produced. In order to efficiently produce retinol at high purity, the precursor and NADPH supply was first enhanced to improve retinoids accumulation in the S. cerevisiae strain constructed from a β-carotene producer by introducing β-carotene 15,15ʹ-dioxygenase, following by screening of heterologous and endogenous oxidoreductases for retinal reduction. Env9 was found as an endogenous retinal reductase and its activity was verified in vitro. By co-expressing Env9 with the E. coli ybbO, as much as 443.43 mg/L of retinol was produced at 98.76% purity in bi-phasic shake-flask culture when the antioxidant butylated hydroxytoluene was added to prevent retinoids degradation. The retinol titer reached 2479.34 mg/L in fed-batch fermentation. The success in selective biosynthesis of retinol would lay a solid foundation for its biotechnological production.
Graphical Abstract
Nemaline myopathy in newly diagnosed systemic lupus erythematosus and Sjögren’s overlap syndrome complicated by macrophage activation syndrome
Authors: Vogel Christina , Manwani Poonam , Cornford Marcia E. , Heinze Emil R. 
Published: March 2022

Abstract
Background
Nemaline myopathies are congenital or acquired muscle disorders that typically present in childhood but can occasionally occur in adults with underlying malignant, infectious or autoimmune disorders. There is a great genetic heterogeneity as well as clinical variability among the disease.

Case presentation
Here, we present a case of nemaline myopathy in a young woman who was newly diagnosed with systemic lupus erythematosus (SLE) and Sjögren’s overlap syndrome complicated by macrophage activation syndrome (MAS). She had no personal or family history of myopathy and was reporting progressive thigh weakness. A muscle biopsy revealed type 1 myofiber predominance with granular material in atrophic myocytes consistent with nemaline myopathy. Her symptoms markedly improved with immunotherapy for her SLE and MAS supporting the diagnosis of sporadic late-onset nemaline myopathy (SLONM) associated with her autoimmune disease.

Conclusions
SLONM is a type of nemaline myopathy that presents in adults and can occasionally be associated with autoimmune disease. In these cases, treatment of the underlying disorder with immunosuppression appears to improve symptoms of myopathy.
Energy management system for a small-scale microgrid
Authors: Iqbal Muhammad Mubashir , Kumar Shubash , Lal Chaman , Kumar Chandar 
Published: March 2022

AbstractIn recent years, the power system has been evolved into microgrids, which are little pockets of self-contained entities. Different distributed, interconnected generation units, loads, and energy storage units make up a typical microgrid system. The increased energy efficiency of these units on microgrids is gaining popularity day by day. Because of their stochastic behavior, renewable generation causes an imbalance in the power system, which needs microgrid energy management. To solve these issues, a variety of novel approaches have been explored in the literature. For the stand-alone microgrid in this research, efficient energy management and control mechanism is adopted. A photovoltaic system, a wind turbine, and a battery energy storage device make up this stand-alone microgrid. The power stability of the hybrid system is ensured by a sophisticated controller. The main purpose of this study is to regulate the DC/DC bidirectional converter (DBC), which connects the Li-ion battery to the DC bus of the stand-alone microgrid. This paper describes the development of a wind/photovoltaic power generation system to the load, as well as MPPT techniques like perturb and observe (P&O). The system is simulated and the results are presented using MPPT techniques. There is no requirement for a specific power model in the suggested method. Only power and voltage system data are used by DBC. A stand-alone microgrid system was simulated using MATLAB.
Normal amygdala morphology in dissociative identity disorder
Authors: Reinders Antje A. T. S. , Dimitrova Lora I. , Schlumpf Yolanda R. , Vissia Eline M. , Nijenhuis Ellert R. S. , Jäncke Lutz , Chalavi Sima , Veltman Dick J. 
Published: March 2022

SummaryStudies investigating the structure of the amygdala in relation to dissociation in psychiatric disorders are limited and have reported normal or preserved, increased or decreased global volumes. Thus, a more detailed investigation of the amygdala is warranted. Amygdala global and subregional volumes were compared between individuals with dissociative identity disorder (DID: n = 32) and healthy controls (n = 42). Analyses of covariance did not show volumetric differences between the DID and control groups. Although several unknowns make it challenging to interpret our findings, we propose that the finding of normal amygdala volume is a genuine finding because other studies using this data-set have presented robust morphological aberrations in relation to the diagnosis of DID.
Parathyroidectomy vs Cinacalcet Among Patients Undergoing Hemodialysis
Authors: Komaba Hirotaka , Hamano Takayuki , Fujii Naohiko , Moriwaki Kensuke , Wada Atsushi , Masakane Ikuto , Nitta Kosaku , Fukagawa Masafumi 
Published: March 2022

Abstract

Context
Parathyroidectomy (PTx) and cinacalcet are both effective treatments for secondary hyperparathyroidism in hemodialysis patients, but limited data exist comparing the long-term outcomes of these interventions.

Objective
We aimed to compare the risk of mortality among hemodialysis patients who underwent PTx and those who started treatment with cinacalcet.

Methods
In this prospective cohort study, comprising patients from the Japanese Society for Dialysis Therapy Renal Data Registry, patients who had intact parathyroid hormone (PTH) levels ≥ 300 pg/mL in late 2007 and underwent PTx or started treatment with cinacalcet in 2008 to 2009 were matched by propensity score at 1:3. PTx and cinacalcet were compared for all-cause mortality within 6 years.

Results
Among eligible patients, 894 patients who underwent PTx were matched with 2682 patients who started treatment with cinacalcet. The median baseline intact PTH levels were 588 pg/mL and 566 pg/mL in the PTx and cinacalcet groups, respectively. PTx resulted in greater reductions in intact PTH, calcium, and phosphorus levels compared with cinacalcet. During the 6-year follow-up period, 201 patients (22.5%) in the PTx group and 736 patients (27.4%) in the cinacalcet group died. PTx was associated with a lower risk of mortality compared with cinacalcet (hazard ratio, 0.78 [95% CI, 0.67-0.91]; P = 0.002). This association was more pronounced in patients with intact PTH levels ≥ 500 pg/mL and in patients with serum calcium levels ≥ 10.0 mg/dL (both P for interaction &lt; 0.001).

Conclusion
PTx compared with cinacalcet is associated with a lower risk of mortality, particularly among patients with severe secondary hyperparathyroidism.
Dispersal of Hoffmannia excelsa (Rubiaceae) by the Toltec fruit-eating bat (Artibeus toltecus) in central Veracruz, México
Authors: Colorado-Durán Wendy Bertha , Espinosa-Francisco Eduardo Keint , Sierra-Vázquez Fabiola , Castro-Luna Alejandro Antonio 
Published: March 2022

En esta nota reportamos el consumo del fruto y dispersión no endozoócora de semillas de una especie vegetal que no había sido mencionada en la dieta de los murciélagos, y que no presenta las características típicas de quiropterocoria. Este evento fue registrado mientras realizábamos capturas nocturnas con redes de niebla, en fragmentos de vegetación secundaria en el área metropolitana de la ciudad de Xalapa de Enríquez, México. Un ejemplar hembra de Artibeus toltecus, capturada en junio de 2018, llevaba consigo dos frutos de Hoffmannia excelsa (Rubiaceae). Aunque H. excelsa es un arbusto común en el centro de Veracruz, éste es el primer registro conocido de dispersión en esta especie, llevada a cabo por murciélagos. El consumo de este fruto, con características ornitócoras, posiblemente obedece a una situación de oportunismo frente a un recurso temporalmente abundante.
New records of Leopardus guigna tigrillo and Lycalopex culpaeus in Placilla de Peñuelas, Chile and threats to their conservation
Authors: Guzmán Marín Byron Cristian , José-González María , Palma Nelson , Guerrero Jimena , Muñoz Peña Patricio 
Published: March 2022

El gato güiña (Leopardus guigna) es considerado vulnerable por la Unión Internacional para la Conservación de la Naturaleza. Por otro lado, aunque el zorro culpeo (Lycalopex culpaeus) se considera especie de menor preocupación en Chile, las áreas protegidas donde se encuentra no son suficientes para mantener poblaciones viables. En este estudio, contribuimos al conocimiento de la fauna de Chile e identificamos amenazas a su conservación mediante fototrampeo. Se colocaron 3 cámaras trampa en la zona de estudio, éstas permanecieron activas durante 2 meses. Las cámaras tomaron fotografías y videos de 30 s, registrando hora y temperatura. Se registró la presencia del gato güiña, subespecie tigrillo (L. g. tigrillo) en la zona de estudio mediante fotografías y videos. Adicionalmente, se registró la presencia de zorro culpeo (L. culpaeus) y evidencia de actividades antropogénicas. Se destaca la presencia de L. g. tigrillo, una especie endémica que se registra por primera vez en la zona de estudio y la de L. culpaeus. Se detectaron actividades antropogénicas (tala ilegal, pastoreo de ganado, motociclismo) que pueden representar una amenaza a la supervivencia de estos carnívoros por lo que proponemos acciones de conservación específicas para proteger a estas especies y su hábitat.
Enhancing English spatial prepositions acquisition among Spanish learners of English as L2 through an embodied approach
Authors: Boieblan Mostafa 
Published: March 2022

AbstractEnglish spatial prepositions posit a great challenge to Spanish learners of English as an L2 due to the broad cross-linguistic differences in how languages structure space. Furthermore, a teaching methodology that could assist these learners in understanding these differences is absent because the pedagogical treatment of spatial language draws on the longstanding assumption that the relation between this kind of language and its meaning is rather arbitrary. Yet, research within the embodiment approach to language and cognition has attested that the use of spatial prepositions is motivated by geometric and functional properties offigureandgroundand how these interact in space. This study examines whether instructing Spanish learners on these properties will enhance their performance. 74 participants at a B1 level were randomized to either receive an embodied approach-based training on spatial prepositions (n = 37) or to the control group (n = 37) without this training. Both groups were presented with a cloze test (60 sentences) on six spatial prepositions,in, on, at, to, into,andontoon pre- and post-test conditions. Scores for both groups were analyzed using ANCOVA with pre-test scores as covariate. Data analysis yields statistically significant results attesting the effectiveness of the Embodiment Approach.
Neutronic studies for the second Egyptian research reactor ET-RR-2
Authors: Ashoub N. , Amin E. 
Published: March 2022

Abstract
The start up physics studies SPS of the Second Egyptian Research Reactor is presented in this work. The SPS consists of the approach to criticality, the power and flux distribution of the first critical core, criticality, power and flux distribution of the working core. The working core is the beryllium-reflected core with cobalt loaded for irradiation. Some of the neutronic parameters are determined, these parameters are the power peaking factor, power distribution, the excess reactivity for both the water and beryllium reflector cores, the core excess reactivity with the cobalt loaded, the reactivity worth of the cobalt irradiation box. Flux distribution for one fast, three eipthermal and one thermal energy group are also determined. All the above neutronic parameters are calculated by using the lattice cell code WIMSD4 and the two dimensional diffusion code DIXY2.
Requirements for quality assurance from the directive REI Mining and other regulations
Authors: Heinrich T. , Knobus B. 
Published: March 2022

Abstract
Many requirements for the quality assurance of the licensee and the independent measuring centre can be derived from the Directive for the “Surveillance of emission and immission of mining work” (REI Mining). However, these should be viewed within the context of “Instructions of measurement related to the surveillance of radioactivity in the environment and to the registration of radioactive emissions from nuclear installations” (MA). Further, it would be advisable to compare the REI Mining requirements to both the Directive for the “Surveillance of emission and immission from nuclear installations” (REI) as well as to the “General administration order to the integrated measuring and information system of the precautionary Radiation Protection Act” (AVV-IMIS). In this article, the various requirements are compared, their common and different aspects are discussed, and possible conclusions for the licensee, the independent measuring centre and the authority of supervision and licencing are presented.
Photon dosimetry using selective data sampling with Particle Swarm optimization algorithm based on NaI(Tl) scintillation detector
Authors: Taheri Balanoji Seyed Mortaza , Zaki Dizaji Hossein , Abdi Saray Akbar 
Published: March 2022

AbstractSodium Iodide doped with Thallium NaI(Tl) scintillation detectors have potential for the development of an active dosimeter for photon radiation. We aim to show that the photon dosimetry response for NaI(Tl) scintillation detector may be optimized by employing the Particle Swarm optimization algorithm, when the selective data sampling is applied for the detector readout. In this work, Sodium Iodide doped with Thallium NaI(Tl) scintillation detector is considered due to being highly sensitive to gamma radiation, and one of the affordable room temperature detectors. In this research, we intend to measure the dosimetry response of the NaI(Tl) detector for various gamma sources, as an example, by measuring the ambient dose equivalent H*(10) for different gamma radioactive sources. Furthermore, we demonstrate that the photon dosimetry response may be well optimized for various energies, especially at lower energies, by increasing the energy interval number in data sampling over the NaI(Tl) scintillation detector readout with the help of an optimization algorithm. The simulation software Geant4 has been used for determining the NaI(Tl) scintillation detector readout. To this end, experimental ambient dose equivalent measurements for gamma radiation sources are compared with the theoretical results. As three and six energy intervals are considered for the selective data sampling along with an optimization algorithm based on NaI(Tl) detector output, the error percentage will be less than 20 and 10%, respectively.
Measuring Everyday Health Information Literacy: A Survey of Pakistani Married Working Women
Authors: Ashraf Summaira , Batool Syeda Hina , Sulehri Imran , Eman Saima , Rehman Ata ur , Mahmood Khalid 
Published: March 2022

Abstract
Health Information Literacy (HIL) influences the decision making of individuals towards the understanding of health-related matters. Married women are the major contributors to family members’ health decisions in a country like Pakistan, where the role of women in family life is very significant. In most families, women are responsible for food selection, cooking, management of the home, including cleanliness etc. Married working women have an integral role both at home and workplace. The current study explores the everyday health information literacy (EHIL) of 213 married working women using a survey research design with a convenient sampling technique from two prominent universities of Lahore, Pakistan. The study’s findings reveal that most of the married working women (3.57 mean value) are well-aware of the sources from where the health-related information can be obtained. Sixty-two percent of the respondents prefer using allopathic healthcare methods for medical treatment. Moreover, 38 percent of women do not understand health-related terminologies. It has been noted that age, education, nature of the job, birthplace, nuclear family system, and educational environment are the significant demographic factors that contribute towards the levels of EHIL.
The crystal structure of [(1,10-phenanthroline-κ2
N,N)-bis(6-phenylpyridine-2-carboxylate-κ2
N,O)nickel(II)] monohydrate, C36H26N4O5Ni
Authors: Wang Li-Hua , Tai Xi-Shi , Ren Xiu-Jie 
Published: March 2022

Abstract
C36H26N4O5Ni, orthorhombic, P212121 (no. 19), a = 10.5860(9) Å, b = 10.6497(6) Å, c = 26.4492(15) Å, β = 90°, V = 2981.8(3) Å3, Z = 4, R

gt
(F) = 0.0341, wR

ref
(F
2) = 0.0703, T = 200 K.
Interactional functions of truncated predicative complement construction “AP + (dek)le” as topic initiator in Shanghai Wu Chinese conversation
Authors: Li Xiaoting , Liu Yaqiong 
Published: March 2022

Abstract“VP/AP + (dek)le + AP/VP” is a predicative complement construction in Shanghai Wu Chinese (SWC) with(dek)lebeing the complement marker. In everyday SWC conversation, the terminal complement is often dropped, forming the Truncated Predicative Complement Construction (TPCC): “AP + (dek)le”. The data for the present study are approximately 4.5 h of naturalistic SWC face-to-face conversations. Adopting the methodology of conversation analysis and interactional linguistics, we explore the interactional functions of the TPCC in the SWC conversational data. We find that TPCCs after the possible closure of a topic are deployed to initiate a new topic in two ways: initiating a disjunctive topic shift, and changing to a topic that is connected to a prior one. The findings demonstrate that TPCCs are routinized grammatical patterns accomplishing the conversational action of initiating new topics in SWC conversation.
Treatment of congenital adrenal hyperplasia in children aged 0–3 years: a retrospective multicenter analysis of salt supplementation, glucocorticoid and mineralocorticoid medication, growth and blood pressure
Authors: Neumann Uta , van der Linde Annelieke , Krone Ruth E , Krone Nils P , Güven Ayla , Güran Tülay , Elsedfy Heba , Poyrazoglu Sukran , Darendeliler Feyza , Bachega Tania A S S , Balsamo Antonio , Hannema Sabine E , Birkebaek Niels , Vieites Ana , Thankamony Ajay , Cools Martine , Milenkovic Tatjana , Bonfig Walter , Costa Eduardo Correa , Atapattu Navoda , de Vries Liat , Guaragna-Filho Guilherme , Korbonits Marta , Mohnike Klaus , Bryce Jillian , Ahmed S Faisal , Voet Bernard , Blankenstein Oliver , Claahsen-van der Grinten Hedi L 
Published: March 2022

Objectives
International guidelines recommend additional salt supplementation during infancy in classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. The influence of corticoid medication and growth has not been assessed.

Aim
To investigate the current use of salt supplementation, fludrocortisone (FC) and hydrocortisone (HC) dosage as well as weight, height, BMI and blood pressure (BP) in CAH children aged 0–3 years.

Methods
Retrospective multicentre analysis using data from the I-CAH registry. Salt-treated (ST) and non-salt-treated (NST) children were compared regarding FC and HC dosage, weight, height and BP at 0, 3, 6, 9, 12, 18, 24, 30, and 36 months.

Results
We analysed 2483 visits of 331 patients born after year 2000 in 13 countries (male, n  = 145) with 203 ST patients (61%). NST children had significantly higher FC dosages at 1.5–4.5 months and higher HC dosages until 1.5 months of age. No differences in weight, length and BP between subgroups were observed. Children of the whole cohort showed increased BMI-SDS during the study period and about half of the reported BP readings were >P95.

Conclusion
In children treated with additional salt supplementation, FC and HC dosages are lower during the first months of life but without differences in weight, length and BP until 3 years of age compared to NST children. All children showed an increase in BMI-SDS and a high rate of BP readings >P95 until 3 years, indicating the start of weight gain and negative effects on blood pressure already in very early life.
Politics and Terrorism of Immanuel Kant‘s Radical Evil
Authors: Grigonis Gintautas 
Published: March 2022

This article analyzes Immanuel Kant’s concept of radical evil within the broader corpus of Kant’s practical works in order to ascertain whether suicidal terrorism can be interpreted using his philosophical framework. Said analysis establishes the dynamic between radical evil and other characteristics of Kantian human nature – unsocial-sociability and propensity towards humanity, whilst focusing on the political implications of said dynamic. When analyzed utilizing the established framework of politics of radical evil, suicidal terrorism reveals the extremities of human behavior as well as potential flaws of Kantian philosophy.
Pandects of Antiochus in the Church Slavonic Prologue (Based on the Readings of the First Half-Year)
Authors: Čistiakova Marina 
Published: March 2022

The article examines the readings from the Pandects of Antiochus as a source for compiling the didactic section of the Church Slavonic Prologue. The research material consists of circa 100 copies of all the known translations and versions of the Prologue for the autumn-winter half-year. In total, 44 readings have been identified as deriving from the Pandects, and in six cases the same sermon is given in two versions. The largest number of readings (21) is present in the extended edition of the Prologue compiled in the 60s of the 12th century. In this group of texts borrowed from the Pandects, the source text has been thoroughly edited. The shortened edition of the Prologue and the subsequent editions of the Prologue compiled on the basis of the oldest versions partially derive from the readings in the extended edition of the Prologue. The Moscow and the Kyrill-Belozersk editions of the Versed prologue were supplemented by individual new readings from the Pandects. The sermons were more actively transferred to the Prologue versions created and/or prevalent in the Grand Duchy of Lithuania, namely, the Kiev-Sophia, the Museum, the Kiev editions and special varieties of the Prologue based on the extended edition.
Księgi Metamorphoseon by W. Otwinowski as the Source for Russian Translations of Ovid’s Metamorphoses in Early 18th Century: Nomination of Sanctuaries
Authors: Matveenko Ekaterina 
Published: March 2022

The article examines the translation of lexemes nominating shrines in Polish Ovid’s Metamorphoses adaptation Księgi Metamorphoseon, to jest, Przemian od Publiusa Owidiusza Nasona Wierszami opisane made by Walerian Otwinowski in 1638. From this Polish verse translation in early 18th century was made both Russian translations of Metamorphoses. Thus the results of present study can be considered also as starting point for further examination of Russian translations. It is determined that in Otwinowski’s version lexeme kościół was chosen as a unified neutral equivalent for some different Latin nominations of pagan sanctuaries. Comparison with another Polish translation of Metamorphoses, Jakob Żebrowski’s Metamorphoseon, to jest Przeobrażenia ksiąg piętnaście (1636), shows that Otwinowski’s decision to translate different Latin lexical equivalents by unified lexical item is a distinctive feature of his translation. For further study in translation techniques in both Russian translations it is important that the Polish origin (Otwinowski’s translation) itself doesn’t represent a field for a variety of translation correspondences within considered lexemes.