bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comment on “Estimates on the Frequency of Volcanic Eruptions on Venus” by Byrne and Krishnamoorthy (2022)
Authors: van Zelst Iris 
Published: November 2022

AbstractByrne and Krishnamoorthy (2022), https://doi.org/10.1029/2021je007040 estimated the frequency of volcanic eruptions on Venus by scaling the eruption frequency obtained from a database containing Earth data. In reproducing their study, I found that the estimated number of new and ongoing volcanic eruptions on Venus in a given year is approximately 42, instead of the previously reported 120 eruptions. This updated estimate of Byrne and Krishnamoorthy (2022) based on the assumption that data from Earth can be scaled to Venus is an important step toward quantifying volcanism on Venus. However, it is important to note that in this estimate, the amount of volcanism associated with rifting is underestimated and subduction‐related volcanism is overestimated. The annual volcanic flux on Venus resultant from the estimated amount of volcanic eruptions aligns with previous estimates of Venus' volcanic flux based on, for example, chemical reaction times and geological mapping. Applying the same method of estimating volcanic eruption frequency to the other terrestrial planets in the Solar System indicates that the Earth scaling method is perhaps not universally applicable, especially concerning bodies with vastly different tectonic regimes.
Shadow Spaces for Water Stress Adaptation: Supplemental Irrigation Application in Rainfed Fig Production
Authors: Sharifzadeh M. , Kamgar‐Haghighi A. A. , Sepaskhah A. R. , Honar T. , Ahmadvand M. , Abdolahipour M. , Kamyab Sh. , Khosrozadeh M. 
Published: November 2022

AbstractThe horticultural management of rainfed fig orchards under water stress conditions has developed using supplemental irrigation (SI) strategy. Diffusion of SI technology requires dealing with orchardists’ demands. The aim of this descriptive survey research was to investigate factors contributing to the SI application by fig growers under semi‐arid conditions. Orchard‐system, demographic features, attitudinal patterns, and economic characteristics of fig growers were assessed to identify the characteristics that lead to, or detract from SI application adoption, when rainfall is insufficient for normal plant growth. The sampling frame contained 377 out of 7,530 fig orchard addresses in Estahban region, southern Iran. Results revealed that higher yield, fruit quality including fruit size (as an indicator for fruit weight), and color of fig fruit were the most important components influencing fig growers’ perception of SI usefulness. SI technology adopters and non‐adopters indicated statistically different results in terms of average income and number of trees. The current research can benefit policymakers, researchers, farmers, water associations, etc. in determining the appropriate supplemental irrigation amount and time, and will be of significant value in water supply planning and higher agricultural productivity, considering the limited water resources.
Consensus statement on the definition of orthostatic hypertension endorsed by the American Autonomic Society and the Japanese Society of Hypertension
Authors: Jordan Jens , Biaggioni Italo , Kotsis Vasilios , Nilsson Peter , Grassi Guido , Fedorowski Artur , Kario Kazuomi 
Published: November 2022

AbstractWe propose a consensus definition of “an exaggerated orthostatic pressor response” in subjects in whom systolic blood pressure increases ≥20 mmHg when going from the supine to standing posture. This definition can be extended for seated to standing measurements. We reserve the term “orthostatic hypertension” if this pressor response leads to an upright systolic blood pressure ≥140 mmHg. We believe this consensus definition will help in the study of the pathophysiology, clinical impact, and potential treatment of these entities, and the identification of patients that are at greater cardiovascular risk.
Structural informatic study of determined and AlphaFold2 predicted molecular structures of 13 human solute carrier transporters and their water-soluble QTY variants
Authors: Smorodina Eva , Diankin Igor , Tao Fei , Qing Rui , Yang Steve , Zhang Shuguang 
Published: November 2022

AbstractSolute carrier transporters are integral membrane proteins, and are important for diverse cellular nutrient transports, metabolism, energy demand, and other vital biological activities. They have recently been implicated in pancreatic cancer and other cancer metastasis, angiogenesis, programmed cell death and proliferation, cell metabolism and chemo-sensitivity. Here we report the study of 13 human solute carrier membrane transporters using the highly accurate AlphaFold2 predictions of 3D protein structures. In the native structures, there are hydrophobic amino acids leucine (L), isoleucine (I), valine (V) and phenylalanine (F) in the transmembrane alpha-helices. These hydrophobic amino acids L, I, V, F are systematically replaced by hydrophilic amino acids glutamine (Q), threonine (T) and tyrosine (Y), thus the QTY code. Therefore, these QTY variant transporters become water-soluble without requiring detergents. We present the superposed structures of these native solute carrier transporters and their water-soluble QTY variants. The superposed structures show remarkable similarity with RMSD ~ 1 Å–< 3 Å despite > 46% protein sequence substitutions in transmembrane alpha-helices. We also show the differences of surface hydrophobicity between the native solute carrier transporters and their QTY variants. Our study may further stimulate designs of water-soluble transmembrane proteins and other aggregated proteins for drug discovery and biotechnological applications.
Reconstruction of 3D topographic landscape in soft X-ray fluorescence microscopy through an inverse X-ray-tracing approach based on multiple detectors
Authors: Ippoliti Matteo , Billè Fulvio , Karydas Andreas G. , Gianoncelli Alessandra , Kourousias George 
Published: November 2022

AbstractThe study of X-ray fluorescence (XRF) emission spectra is a powerful technique used in applications that range from biology to cultural heritage. Key objectives of this technique include identification and quantification of elemental traces composing the analyzed sample. However, precise derivation of elemental concentration is often hampered by self-absorption of the XRF signal emitted by light constituents. This attenuation depends on the amount of sample present between the radiation source and detection system and allows for the exploitation of self-absorption in order to recover a sample topography. In this work, an X-ray-tracing application based on the use of multiple silicon drift detectors, is introduced to inversely reconstruct a 3D sample with correct topographical landscape, from 2D XRF count rates maps obtained from spectroscopy. The reconstruction was tested on the XRF maps of a simulated sample, which is composed of three cells with different size but similar composition. We propose to use the recovered 3D sample topography in order to numerically compute the self-absorption effects on the X-ray fluorescence radiation, thereby showing that a quantitative correction is possible. Lastly, we present a web application which implements the suggested methodology, in order to demonstrate its feasibility and applicability, available at: https://github.com/ElettraSciComp/xrfstir.
A methodological review with meta-epidemiological analysis of preclinical systematic reviews with meta-analyses
Authors: Simon-Tillaux Noémie , Gerard Anne-Laure , Rajendrabose Deivanes , Tubach Florence , Dechartres Agnès 
Published: November 2022

AbstractSystematic reviews and meta-analyses have been proposed as an approach to synthesize the literature and counteract the lack of power of small preclinical studies. We aimed to evaluate (1) the methodology of these reviews, (2) the methodological quality of the studies they included and (3) whether study methodological characteristics affect effect size. We searched MEDLINE to retrieve 212 systematic reviews with meta-analyses of preclinical studies published from January, 2018 to March, 2020. Less than 15% explored the grey literature. Selection, data extraction and risk of bias assessment were performed in duplicate in less than two thirds of reviews. Most of them assessed the methodological quality of included studies and reported the meta-analysis model. The risk of bias of included studies was mostly rated unclear. In meta-epidemiological analysis, none of the study methodological characteristics was associated with effect size. The methodological characteristics of systematic reviews with meta-analyses of recently published preclinical studies seem to have improved as compared with previous assessments, but the methodological quality of included studies remains poor, thus limiting the validity of their results. Our meta-epidemiological analysis did not show any evidence of a potential association between methodological characteristics of included studies and effect size.
Alcohol use patterns and risk of incident cataract surgery: a large scale case–control study in Japan
Authors: Fukai Kota , Terauchi Ryo , Furuya Yuko , Sano Kei , Nakazawa Shoko , Kojimahara Noriko , Hoshi Keika , Nakano Tadashi , Toyota Akihiro , Tatemichi Masayuki 
Published: November 2022

AbstractTo examine the risk of incident cataract surgery associated with alcohol use patterns among Japanese adults. This was a case–control study evaluating 14,861 patients with incident cataract surgery and 14,861 matched controls. Subjects admitted to any of the 34 hospitals in Japan and aged between 40 and 69 years were included. Drinking patterns (drinking frequency, daily average drinks, and total amount of lifetime drinking), smoking history, lifestyle-related comorbidities, and occupational factors were surveyed by trained interviewers. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression models. For drinking frequency, ORs in the 1–3 days/week and 4–7 days/week groups were 1.10 (95% CI 1.03–1.17) and 1.30 (1.21–1.40), respectively. For average drinks, ORs in > 0–2 drinks/day, > 2–4 drinks/day, and > 4 drinks/day were 1.13 (1.06–1.20), 1.23 (1.12–1.35), and 1.16 (1.03–1.31), respectively. Both men and women had an increased risk of incident cataract surgery with increased total lifetime drinking, with a significant increase in risk occurring at > 90 drink-years for men and > 40 drink-years for women. A positive dose–response relationship was observed between alcohol consumption and cataract. Restricted drinking may help to reduce the progression of cataracts.
The prevalence of cardiac complications and their impact on outcomes in patients with non-traumatic subarachnoid hemorrhage
Authors: Lång Maarit , Jakob Stephan M. , Takala Riikka , Lyngbakken Magnus N. , Turpeinen Anu , Omland Torbjørn , Merz Tobias M. , Wiegand Jan , Grönlund Juha , Rahi Melissa , Valtonen Mika , Koivisto Timo , Røsjø Helge , Bendel Stepani 
Published: November 2022

AbstractSubarachnoid hemorrhage (SAH) is a serious condition, and a myocardial injury or dysfunction could contribute to the outcome. We assessed the prevalence and prognostic impact of cardiac involvement in a cohort with SAH. This is a prospective observational multicenter study. We included 192 patients treated for non-traumatic subarachnoid hemorrhage. We performed ECG recordings, echocardiographic examinations, and blood sampling within 24 h of admission and on days 3 and 7 and at 90 days. The primary endpoint was the evidence of cardiac involvement at 90 days, and the secondary endpoint was to examine the prevalence of a myocardial injury or dysfunction. The median age was 54.5 (interquartile range [IQR] 48.0–64.0) years, 44.3% were male and the median World Federation of Neurological Surgeons (WFNS) score was 2 (IQR 1–4). At day 90, 22/125 patients (17.6%) had left ventricular ejection fractions ≤ 50%, and 2/121 patients (1.7%) had evidence of a diastolic dysfunction as defined by mitral peak E-wave velocity by peak eʹ velocity (E/eʹ) > 14. There was no prognostic impact from echocardiographic evidence of cardiac complications on neurological outcomes. The overall prevalence of cardiac dysfunction was modest. We found no demographic or SAH-related factors associated with 90 days cardiac dysfunction.
A validated geomechanical model for the strike-slip restraining bend in Lebanon
Authors: Fedorik Jakub , Maesano Francesco E. , Afifi Abdulkader M. 
Published: November 2022

AbstractMost of the methodologies used to validate complex strike-slip structures mainly rely on comparison with other well-known geological features or analogue laboratory models. This study adopts an approach based on the boundary element method at the regional scale to test the structural interpretation of a complex transpressional mountain range. Lebanon restraining bend represents the most prominent topographic transpressional feature along the Dead Sea Transform (DST). It consists of two mountain ranges: the Mount Lebanon and the Anti-Lebanon ranges. We built a 3D geometrical model of the fault surfaces based on previously studied natural examples, structural maps, satellite images, DEM interpretation and experimental analogue models of restraining bend or transpressional structures. Using a boundary element method, we modelled fault deformation response to the regional stress field. The simulation accurately predicts the shape and magnitude of positive and negative topographic changes and fault slip directions throughout the study area. We propose an original approach, which uses implementation of well-known fault geometries, surface and subsurface data, for structural validation in the complex strike-slip domain. Our results, validated by structural evidences, highlight that various structural styles lead to formation of Mt. Lebanon, Anti-Lebanon and Palmyrides structures. Furthermore, this simulation supports the hypothesis that the restraining bend of the DST formed in the widespread crustal weakness zone developed in the Late Jurassic to Early Createceous. We also propose recent Neogene tectonic evolution of the region based on our modelling and integrated with published U/Pb dating of fault zones and tectonostratigraphic evidence.
Angiopoietin-like 2 is essential to aortic valve development in mice
Authors: Labbé Pauline , Munoz Goyette Victoria , Thorin-Trescases Nathalie , Villeneuve Louis , Desanlis Ines , Delwarde Constance , Shi Yan-Fen , Martel Cécile , Yu Carol , Alikashani Azadeh , Mamarbachi Maya , Lesage Frédéric , Mathieu Samuel , Tardif Jean-Claude , Mathieu Patrick , Kmita Marie , Thorin Éric 
Published: November 2022

AbstractAortic valve (AoV) abnormalities during embryogenesis are a major risk for the development of aortic valve stenosis (AVS) and cardiac events later in life. Here, we identify an unexpected role for Angiopoietin-like 2 (ANGPTL2), a pro-inflammatory protein secreted by senescent cells, in valvulogenesis. At late embryonic stage, mice knocked-down for Angptl2 (Angptl2-KD) exhibit a premature thickening of AoV leaflets associated with a dysregulation of the fine balance between cell apoptosis, senescence and proliferation during AoV remodeling and a decrease in the crucial Notch signalling. These structural and molecular abnormalities lead toward spontaneous AVS with elevated trans-aortic gradient in adult mice of both sexes. Consistently, ANGPTL2 expression is detected in human fetal semilunar valves and associated with pathways involved in cell cycle and senescence. Altogether, these findings suggest that Angptl2 is essential for valvulogenesis, and identify Angptl2-KD mice as an animal model to study spontaneous AVS, a disease with unmet medical need.
NMR insights into dynamic, multivalent interactions of intrinsically disordered regions: from discrete complexes to condensates
Authors: Ahmed Rashik , Forman-Kay Julie D. 
Published: November 2022

Abstract
The spatial and temporal organization of interactions between proteins underlie the regulation of most cellular processes. The requirement for such interactions to be specific predisposes a view that protein–protein interactions are relatively static and are formed through the stable complementarity of the interacting partners. A growing body of reports indicate, however, that many interactions lead to fuzzy complexes with an ensemble of conformations in dynamic exchange accounting for the observed binding. Here, we discuss how NMR has facilitated the characterization of these discrete, dynamic complexes and how such characterization has aided the understanding of dynamic, condensed phases of phase-separating proteins with exchanging multivalent interactions.
Networked predictive control method of multi‐vehicle cooperative control at communication‐constrained unsignalized multi‐intersection
Authors: Yu Jie , Jiang Fachao , Luo Yugong , Kong Weiwei 
Published: November 2022

AbstractTo reduce the degradation of multi‐vehicle cooperative control performance for connected and automated vehicles caused by time‐varying communication delays when the edge‐cloud is used for centralized control through the vehicle to infrastructure communication, and further improve the traffic efficiency based on driving safety at unsignalized multi‐intersection. A networked predictive control method based on an improved model‐free adaptive predictive control method and multi‐intersection distributed cooperative control scheme is proposed to realize the multi‐vehicle cooperative control under the conditions of time‐varying communication delays at an unsignalized multi‐intersection system, including multi‐intersection edge‐cloud networked predictive control layer and multi‐vehicle car‐following control layer. The control objective can be calculated by the moving horizon prediction control scheme based on compact form dynamic linearization technology through the edge computing controller, and then assigns the anticipated speed to each target vehicle entering the intersection subsystem based on decoupling the unsignalized multi‐intersection system into the multiple networked control intersection subsystems. The extensive numerical simulation results confirmed the benefits of the proposed scheme compared to the benchmark methods.
Design and FEM analysis of high‐power density C‐core permanent magnet transverse flux generator with reduced PM volume
Authors: Muhammad Ali , Khan Faisal , Ullah Basharat , Milyani Ahmad H. , Azhari Abdullah A. 
Published: November 2022

AbstractTransverse flux machines are made up of armature coils wound in a circular direction and surrounded by armature cores. This configuration enables machines to be designed for multi‐pole structures while maintaining a simple coil geometry regardless of the pole count. As a result, these machines generate more torque and power density than most of the machines with windings wound around teeth and inserted into slots. However, transverse flux machines continue to face manufacturing difficulties because a large number of relatively small permanent magnets are required. Thus, a permanent magnet transverse flux generator (PMTFG) is designed with half the magnets on the rotor in comparison with a regular design while generating 18% better power density at the same size and excitation conditions. After proper parameter selection, the electromagnetic performance of the design is examined, and the viability of the design is verified using a three‐dimensional finite‐element model (FEM). Further analyses were carried out to examine the effect of stator core material and air gap length on the performance of PMTFG. Furthermore, a prototype of the proposed topology is built, which validates the performance obtained through FEM.
Coordinated control strategy for vehicle‐to‐grid support at distribution node
Authors: Thirugnanam Kannan , Yuen Chau , Kumar Praveen , Ghaoud Tareg , Sgouridis Sgouris 
Published: November 2022

AbstractThe increasing number of electric vehicles (EVs) creates voltage rise/drop problems when integrated into a distribution node (DN). This generally occurs when EVs inject energy to or draw energy from the DN in a stochastic manner. A vehicle‐to‐grid service for voltage support of DN through controlled and coordinated EV charging and discharging techniques to maintain the DN voltage within the threshold limits is proposed. In this context, a fuzzy logic control (FLC) is developed to generate reference power signal and the power flow direction based on DN voltage and electric vehicle charging station’s (EVCS) available energy. Here, the EVCS is a place where the EVs are charged and/or participate for grid support. Then, an EVCS aggregator is implemented to coordinate the large fleet of EVs based on FLC output and EV’s available energy. Furthermore, an EV’s battery charge and discharge rate controller is developed to control the EV’s energy based on EVCS aggregator output and charge/discharge rate threshold limits. Finally, an active and reactive power control methodology is implemented to maintain DN voltage profile within the threshold limits. Extensive simulations are conducted based on real data from a radial distribution system. The results show that the EVCS can successfully maintain the DN voltage within the threshold limit through the proposed control and coordination strategy.
Endoscopic laser endomicroscopy and “leaky gut” in patients with functional gastrointestinal symptoms and food intolerance
Authors: Frieling Thomas , Gjini Besmir , Melchior Ilka , Euler Philipp , Kreysel Christian , Kalde Sigrid , Krummen Britta , Kiesslich Ralf , Hemmerlein Bernhard 
Published: November 2022

Abstract
Background Intestinal epithelial barrier dysfunction (“leaky gut
syndrome”, LGS) is thought to play a major role in the pathogenesis of disorders of the gut
brain axis. Endoscopic confocal laser endomicroscopy (eCLE) is an objective measure to test
duodenal permeability. We applied this technique in patients with functional gastrointestinal
symptoms and food intolerance to characterize the proportion of patients with LGS.
Material and Methods In an observational study, we evaluated 85
patients with functional gastrointestinal symptoms and food intolerance. Gastrointestinal
symptoms were classified according to Rom IV into functional abdominal pain (FAP), irritable
bowel syndrome (IBS), irritable bowel syndrome diarrhea dominant (IBS-D), irritable bowel
syndrome constipation dominant (IBS-C), irritable bowel syndrome with mixed stool (IBS-M),
functional abdominal bloating (FAB), functional diarrhea (FD) and unclassified (NC). During
eCLE, spontaneous transfer of intravenously applied fluorescein into duodenal lumen (LGS) and
following duodenal food challenge (DFC) were analyzed. Blood analysis comprised parameters of mast cell
function, histology of duodenal mucosal biopsies analysis of mucosal inflammation,
intraepithelial lymphocytes (IELs) as well as number, distribution and morphology of mast
cells.
Results 24 patients (9 IBS, 9 FAP, 3 FAB, 1 FD, 2 NC), showed
LGS, 50 patients (14 IBS-D, 4 IBS-C, 3 IBS-M, 23 FAP, 3 FAB, 3 NC) had no LGS but responded to
DFC and 11 patients (6 NC, 3 FAP, 1 FAB, 1 FD) had no LGS and no response to DFC. The
proportion of subgroups with/or without spontaneous leakage of fluorescein (+LGS/-LGS) were
IBS-LGS/IBS+LGS 67%/33%, FAP-LGS/FAP+LGS 72%/28%,FAB-LGS/FAB+LGS 50%/50%, NC-LGS/NC+LGS
60%/40%. Subgroup analysis revealed no significant differences for all parameters
tested.
Conclusion As a proof of concept, the results of our study
indicate that eCLE is a clinical useful tool to evaluate patients with disorders of the gut
brain axis and those suspicious of LGS. However, the clinical significance of LGS remains
unclear. The study should be an incentive to perform a randomized study including healthy
controls.