bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Kolam Drawing: A Point Lattice System
Authors: Sarin Anika 
Published: July 2022

Abstract
Kolam is the 5,000-year-old art of making geometric floor drawings with rice flour, practiced by the Dravidian women of South India. This article introduces a point lattice-based method of visual organization that is derived from Kolam drawings. In it, a point lattice formed by a regularly spaced array of points is used to structure visual compositions, as an alternative to a network of orthogonal lines (also known as the grid). First, I show how the point lattice system is used to structure Kolam drawing compositions, including the lattice's construction, types, and uses. Second, through a formal analysis of such a points system in structuring forms, patterns, letters, and layouts in graphic design, I show that this system offers a whole alternate universe of compositional possibilities that are not apparent when graphic designers see a grid not as points, but as a series of constraining straight lines. Through this research, I look inward into the design ethos and tools present in Indian arts and crafts and present its application in contemporary design practice.
North Pacific and North Atlantic Jet Covariability and Its Relationship to Cool Season Temperature and Precipitation Extremes
Authors: Winters Andrew C. , Attard Hannah E. 
Published: July 2022

Abstract
Cool season (September–May) extreme temperature and precipitation events are frequently tied to surface cyclones and anticyclones, which are modulated on the synoptic scale by the state and evolution of the upper-tropospheric jet stream. This study adopts a jet-centered approach to classify the prevailing large-scale flow pattern into jet regimes based on the leading modes of variability of the North Pacific jet (NPJ) and the North Atlantic jet (NAJ), respectively. The characteristics of these joint NPJ–NAJ regimes are subsequently examined using composite analysis to identify large-scale flow environments conducive to the occurrence of anomalous temperatures and precipitation across North America. The analysis reveals that composite large-scale flow environments associated with each joint NPJ–NAJ regime can be approximated as a linear combination of the separate large-scale environments that characterize each NPJ regime and NAJ regime independently. Furthermore, knowledge of the joint NPJ–NAJ regime provides more precision regarding the relative likelihood and spatial coverage of anomalous temperatures and precipitation than would be obtained from consideration of the NPJ or NAJ regime in isolation. The frequencies of each joint NPJ–NAJ regime can also be modulated by the occurrence of sudden stratospheric warmings, with increased frequencies of an equatorward-shifted NAJ and a retracted NPJ during the 30-day period following a warming event. The results from the present study demonstrate that knowledge of the joint NPJ–NAJ regime exhibits the potential to inform forecasts of anomalous temperatures and precipitation at medium-range and subseasonal time scales.

Significance Statement
The development of cool season temperature and precipitation extremes are modulated by the state and evolution of the upper-tropospheric jet stream. Therefore, this study adopts a jet-centered approach to quantify the extent to which temperature and precipitation extremes over North America are related to the coevolution of the North Pacific and North Atlantic segments of the jet stream. The analysis demonstrates that the relative likelihood and spatial coverage of temperature and precipitation extremes varies significantly across North America based on the combined state of the North Pacific and North Atlantic jets. The jet-centered approach utilized in this study exhibits the potential to inform operational medium-range (6–10 day) and subseasonal forecasts of temperature and precipitation across North America.
Single-Bubble Sonoluminescence of Colloidal Suspensions as a New Technique for Sonoluminescent Spectroscopic Analysis
Authors: Gareev Bulat M. , Abdrakhmanov Airat M. , Sharipov Glyus L. 
Published: July 2022

This is a brief research review on the new method of development for element luminescence determination, namely, sonoluminescent spectroscopy. The advantages and disadvantages of the technique of multibubble sonoluminescence (MBSL) in solutions used to apply this method are discussed. It has been shown that the use of a new technique moving single-bubble sonoluminescence (m-SBSL) in colloidal suspensions of nanoparticles (<50 nm) containing the elements analyzed seems preferable for this purpose. This makes it possible to determine elements not only at lower concentrations than when using MBSL in solutions but also to find elements that are unavailable for determination through previous techniques. Thus, this new technique expands the range of elements that can be determined using sonoluminescent spectroscopy. The article provides a detailed description of the standard procedure for the preparation and recording of m-SBSL in colloidal suspensions, as well as examples of characteristic spectra of some elements obtained and recorded for the first time according to this new technique (Al, K, Mn, Cd, Pt, Ni, and Ti), including those not previously found using the MBSL in solutions (Al, Cd, Pt, Ni, and Ti). An example of the analytical line at 396 nm in the Al spectrum obtained through this new technique on the basis of an AlCl3 initial aqueous solution, the region of the linear dependence of the intensity on the AlCl3 concentration was registered, and the lower limit of the spectroscopic determination of the Al content in this solution was estimated as 8.3·10−3 M. Using the analysis of the obtained Cd spectrum as an example, we carried out a spectroscopic measurement of the electronic temperature achieved at m-SBSL in bubble plasma at the moment of greatest compression of a bubble with light emission during its acoustic oscillations in dodecane, Te = 7900 ± 500 K.
The epidemiology of delayed HIV diagnosis in Ibadan, Nigeria
Authors: Oluwalana Michael O , Awolude Olutosin A , Gao Zhiwei , Daley Peter K 
Published: July 2022

Background Human immunodeficiency virus infection (HIV) is one of the major health burdens in Nigeria. Delayed HIV diagnosis remains a significant driver of HIV transmission. The risk factors of delayed HIV diagnosis have not been widely studied in Nigeria. This observational study examined demographic risk factors for delayed HIV diagnosis and the trends in the annual total cases of delayed HIV diagnosis in Ibadan, Nigeria. Methods We examined the data on HIV patients enrolled in care at the University College Hospital’s Antiretroviral Therapy (ART) clinic in Ibadan, Nigeria. Delayed HIV diagnosis was defined as a Cluster of Differentiation 4 (CD4) count of less than 350 cells/mm³ at the time of diagnosis. The association between delayed HIV diagnosis and risk factors was analyzed using logistic regression. The trends in the annual total cases of delayed HIV diagnosis over time were examined. Results This study included 3458 HIV patients. There were 1993/3458 prevalent cases of delayed HIV diagnosis (57.6%). The risk factors for delayed HIV diagnosis were older age, retirement, marriage separation, never married, and widowed female. The factors that were significantly associated with a low risk of delayed HIV diagnosis were student and tertiary education. There was a progressive decline in the annual cases of delayed HIV diagnosis. Conclusions Although the cases of delayed HIV diagnosis are still high, they are declining. Human immunodeficiency virus testing should be targeted at populations at risk of delayed diagnosis. Considerable public awareness and education programs about HIV testing may significantly reduce delayed HIV diagnosis in Nigeria.
School-based Child Sexual Abuse Interventions: A Systematic Review and Meta-analysis
Authors: Lu Mengyao , Barlow Jane , Meinck Franziska , Walsh Kerryann , Wu Yumeng 
Published: July 2022

Purpose The purposes of this systematic review were to systematically summarize components in existing school-based child sexual abuse (CSA) prevention programs and identify predictors for program effectiveness. Method Building upon the most comprehensive systematic review on this topic, we conducted systematic searches in both English-language from September 2014 to October 2020 and Chinese-language from inception to October, 2020. Meta-regressions were performed to identify predictors for program effectiveness. Results Thirty-one studies were included with a total sample size of 9049 participants. Results from meta-analyses suggested that interventions are effective in increasing participants’ CSA knowledge as assessed via questionnaires ( g = 0.72, 95% CI [0.52–0.93]) and vignette-based measures ( g = 0.55, 95% CI [0.35–0.74]). Results from meta-regression suggested that interventions with more than three sessions are more effective than interventions with fewer sessions. Interventions appear to be more effective with children who are 8 years and older than younger children. Discussion CSA is a global issue that has significant negative effects on victims’ physical, psychological, and sexual well-being. Our findings also provide recommendations for future research, particularly in terms of optimizing the effectiveness of school-based CSA prevention programs, and the better reporting of intervention components as well as participant characteristics.
Prevalence of Sexual Dysfunction in Women With Depression: Need for Psychosexual Health Promotion Approach
Authors: Chandel Surbhi , Kumar Rajesh , Rohilla Jitendra 
Published: July 2022

Introduction: Depression-associated sexual dysfunction (SD) is a pervasive and ignorant problem among the general population. The antidepressant used to treat depression may further alter the sexual response cycle in one way or another. This study aims to assess the prevalence of SD in females with major depressive disorders and the effects of antidepressant therapy after 4 weeks of follow-ups. Material and Methods: In a prospective observational survey, 94 women diagnosed with depression and on antidepressant therapy were purposively enrolled. Female Sexual Functioning Index (FSFI) and Montgomery-Asberg Depression Rating Scale (MADRS) are administered at baseline and 4 weeks of treatment to measure sexual function and depression changes. Relevant descriptive and inferential statistics are applied to compute the results. Results: The mean age of the participants was 35.87 (±5.10) years. A total of 95.7% of participants showed SD at baseline assessment. There was a significant difference (31.87 vs 18.51, P < .001) in depression from baselines to 4 weeks after antidepressant therapy. Further, a significant negative correlation was reported between the MADRS scores and the scores of arousals (r = −0.396, P < .001), lubrication (r = −0.453, P < .001), orgasm (r = −0.342, P < .001), satisfaction (r = −0.407, P < .001), pain (r = −0.362, P < .001), and total domains of FSFI (r = −0.412, P < .001) after 4 weeks. Using cut-off scores of different areas, decreased sexual desire was reported in 97.9%, poor vaginal lubrication (100%), a problem with arousal (100%), reduced satisfaction (96.8%), reduced ability to achieve orgasm (100%), and pain during sexual intercourse in 100% of the participants. Conclusions: There is a high prevalence of SD in women with depression. There is a marked improvement in depression at the end of 4 weeks. However, sexual function status remains unchanged and indicates the need for time to improve, suggesting different study designs.
Effect of asthma management with exhaled nitric oxideversususual care on perinatal outcomes
Authors: Murphy Vanessa E. , Jensen Megan E. , Holliday Elizabeth G. , Giles Warwick B. , Barrett Helen L. , Callaway Leonie K. , Bisits Andrew , Peek Michael J. , Seeho Sean K. , Abbott Alistair , Robijn Annelies L. , Colditz Paul B. , Searles Andrew , Attia John , McCaffery Kirsten , Hensley Michael J. , Mattes Joerg , Gibson Peter G. 
Published: July 2022

IntroductionAsthma exacerbations in pregnancy are associated with adverse perinatal outcomes. We aimed to determine whether fractional exhaled nitric oxide (FENO)-based asthma management improves perinatal outcomes compared to usual care.MethodsThe Breathing for Life Trial was a multicentre, parallel-group, randomised controlled trial conducted in six hospital antenatal clinics, which compared asthma management guided byFENO(adjustment of asthma treatment according to exhaled nitric oxide and symptoms each 6–12 weeks) to usual care (no treatment adjustment as part of the trial). The primary outcome was a composite of adverse perinatal events (preterm birth, small for gestational age (SGA), perinatal mortality or neonatal hospitalisation) assessed using hospital records. Secondary outcomes included maternal asthma exacerbations. Concealed random allocation, stratified by study site and self-reported smoking status was used, with blinded outcome assessment and statistical analysis (intention to treat).ResultsPregnant women with current asthma were recruited; 599 to the control group (608 infants) and 601 to the intervention (615 infants). There were no significant group differences for the primary composite perinatal outcome (152 (25.6%) out of 594 control, 177 (29.4%) out of 603 intervention; OR 1.21, 95% CI 0.94–1.56; p=0.15), preterm birth (OR 1.14, 95% CI 0.78–1.68), SGA (OR 1.06, 95% CI 0.78–1.68), perinatal mortality (OR 3.62, 95% CI 0.80–16.5), neonatal hospitalisation (OR 1.24, 95% CI 0.89–1.72) or maternal asthma exacerbations requiring hospital admission or emergency department presentation (OR 1.19, 95% CI 0.69–2.05).ConclusionFENO-guided asthma pharmacotherapy delivered by a nurse or midwife in the antenatal clinic setting did not improve perinatal outcomes.
Practical application of a Bayesian network approach to poultry epigenetics and stress
Authors: Videla Rodriguez Emiliano A. , Pértille Fábio , Guerrero-Bosagna Carlos , Mitchell John B. O. , Jensen Per , Smith V. Anne 
Published: July 2022

Abstract
Background
Relationships among genetic or epigenetic features can be explored by learning probabilistic networks and unravelling the dependencies among a set of given genetic/epigenetic features. Bayesian networks (BNs) consist of nodes that represent the variables and arcs that represent the probabilistic relationships between the variables. However, practical guidance on how to make choices among the wide array of possibilities in Bayesian network analysis is limited. Our study aimed to apply a BN approach, while clearly laying out our analysis choices as an example for future researchers, in order to provide further insights into the relationships among epigenetic features and a stressful condition in chickens (Gallus gallus).

Results
Chickens raised under control conditions (n = 22) and chickens exposed to a social isolation protocol (n = 24) were used to identify differentially methylated regions (DMRs). A total of 60 DMRs were selected by a threshold, after bioinformatic pre-processing and analysis. The treatment was included as a binary variable (control = 0; stress = 1). Thereafter, a BN approach was applied: initially, a pre-filtering test was used for identifying pairs of features that must not be included in the process of learning the structure of the network; then, the average probability values for each arc of being part of the network were calculated; and finally, the arcs that were part of the consensus network were selected. The structure of the BN consisted of 47 out of 61 features (60 DMRs and the stressful condition), displaying 43 functional relationships. The stress condition was connected to two DMRs, one of them playing a role in tight and adhesive intracellular junctions in organs such as ovary, intestine, and brain.

Conclusions
We clearly explain our steps in making each analysis choice, from discrete BN models to final generation of a consensus network from multiple model averaging searches. The epigenetic BN unravelled functional relationships among the DMRs, as well as epigenetic features in close association with the stressful condition the chickens were exposed to. The DMRs interacting with the stress condition could be further explored in future studies as possible biomarkers of stress in poultry species.
The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
Authors: Mahlobo Bongiwe , Laher Faatima , Smidt Werner , Ogunshola Funsho , Khaba Trevor , Nkosi Thandeka , Mbatha Anele , Ngubane Thandekile , Dong Krista , Jajbhay Ismail , Pansegrouw Johan , Ndhlovu Zaza M. 
Published: July 2022

Abstract
Background
HIV eradication efforts have been unsuccessful partly due to virus persistence in immune sanctuary sites such as germinal centres within lymph node (LN) tissues. Recent evidence suggests that LNs harbour a novel subset of regulatory T cells, termed follicular regulatory T cells (TFRs), but their role in HIV pathogenesis is not fully elucidated.

Results
Paired excisional LN and peripheral blood samples obtained from 20 HIV-uninfected and 31 HIV-infected treated and 7 chronic untreated, were used to determine if and how HIV infection modulate frequencies, function and spatial localization of TFRs within LN tissues. Imaging studies showed that most TFRs are localized in extra-follicular regions. Co-culture assays showed TFRs suppression of TFH help to B cells. Importantly, epigenetic and transcriptional studies identified DPP4 and FCRL3 as novel phenotypic markers that define four functionally distinct TFR subpopulations in human LNs regardless of HIV status. Imaging studies confirmed the regulatory phenotype of DPP4+TFRs.

Conclusion
Together these studies describe TFRs dynamic changes during HIV infection and reveal previously underappreciated TFR heterogeneity within human LNs.
Anti-dipeptidyl-peptidase-like protein 6 encephalitis with pure cerebellar ataxia: a case report
Authors: Lin Jing , Zhu Min , Mao Xiaocheng , Jin Zeqing , Zhou Meihong , Hong Daojun 
Published: July 2022

Abstract
Background
Anti-dipeptidyl-peptidase-like protein 6 (DPPX) encephalitis is a rare autoimmune encephalitis. The clinical symptoms of anti-DPPX encephalitis are often severe, manifested as diarrhea/weight loss, central nervous system hyperexcitability and cognitive dysfunction.

Case presentation
An 18-year-old boy was admitted for 1-week-long cerebellar symptoms including dizziness, unsteady gait and frequent vomiting. Magnetic resonance imaging (MRI) displayed no abnormal findings. However, autoimmune encephalitis panel revealed anti-DPPX antibody was positive in the serum. This patient completely recovered after immunoglobulin and corticoids therapy. In addition, repeat serum antibody test for DPPX was negative within one month.

Conclusion
In addition to the classic triad, anti-DPPX encephalitis may manifest as mild and rare symptoms due to lower antibody titers. Fast identification of rare symptoms can help to quickly diagnosis and effective treatment.
Differences in cognition, short-chain fatty acids and related metabolites in pregnant versus non-pregnant women: a cross-sectional study
Authors: Luo Huijuan , Li Wengxiang , Wu Lulu , Zhong Shuming , Du Chengrong , Liu Yimeng , Xu Yating , Huang Xinyu , Bahru Awol Hanan , Tang Xiaomei , Zhou Juan , Wang Dongju , Lou Xiangying , Bin Xuefan , Xiao Xiaomin 
Published: July 2022

Abstract
Background
Pregnancy induces cognitive reorganization which can lead to mental disorders. The aim of this study is to determine differences in cognitive scores, short-chain fatty acids (SCFAs) and related metabolites between pregnant and non-pregnant participants.

Methods
This cross-sectional study included 67 full-term pregnant women and 31 non-pregnant women. We compared scores of mental state and cognitive assessment tests, as well as serum concentrations of SCFAs, hormones, inflammatory factors, and neurotransmitters between these groups.

Results
Scores for information processing speed, immediate visual memory, motor response speed and accuracy, execution ability and verbal use ability in the pregnant group were lower than those in the non-pregnant group (p < 0.05 for all tests). Total serum SCFAs in the pregnant group were significantly lower than those in the non-pregnant group (P = 0.031). Among them, acetate and propionate were significantly decreased (P = 0.013 and 0.037, respectively) whereas butyrate was significantly increased (P = 0.035). Serum peptide YY, glucagon-like peptide-1, γ-aminobutyric acid, and dopamine showed no differences between the two groups. However, cortisol, adrenocorticotropic hormone, and acetylcholine were significantly increased in the pregnant group as compared with the non-pregnant group (P = 0.039, 0.016, and 0.012, respectively). Tumor necrosis factor-α was increased and interleukin-10 significantly decreased in the pregnant group (P = 0.045 and 0.019, respectively).

Conclusion
According to our study findings, cognitive reorganization in the third trimester of pregnancy showed that both the passive storage capacity of working memory and the executive function of online information processing were decreased to varying degrees. At the same time, the changes in total SCFAs, the proportions of SCFAs and related metabolites were also detected. These changes in the internal environment may be increasing the risk of perinatal mental illness.
Comparison of clinical outcomes with proximal femoral nail anti-rotation versus bipolar hemiarthroplasty for the treatment of elderly unstable comminuted intertrochanteric fractures
Authors: Song Qi-Chun , Dang Sha-Jie , Zhao Yan , Wei Ling , Duan Da-Peng , Wei Wen-Bo 
Published: July 2022

Abstract
Background
Although proximal femoral nail anti-rotation (PFNA) and bipolar hemiarthroplasty (BHA) are selected by most of the orthopaedic surgeons for elderly intertrochanteric fractures (ITFs) patients, there is still no consensus on the superiority of PFNA and BPH for the elderly with unstable comminuted ITFs. The study aims to compare the curative effects of PFNA and cementless BHA on unstable comminuted ITFs in the elderly.

Methods
From January 2012 to December 2016, we retrospectively reviewed 62 ITFs patients up to the inclusion and exclusion criteria in the study. Depending on the type of surgery, the patients were divided into two groups: Group BHA (n= 30) and Group PFNA (n = 32). The ITFs were classified according to Evans-Jensen. Hospitalization time, operation time, bleeding loss, weight bearing duration, Harris hip scores, 10-m walking speed, gait and postoperative complications were compared between the two groups.

Results
There was no significant difference between the groups in hospital stay (P > 0.05). The BHA group trended to have a shorter operation time and a larger volume of blood loss (P < 0.01).The weight bearing duration was shorter in the BHA group than the PFNA group (P < 0.05).The Harris hip score was higher, the 10-m walking speed was faster and the gait was better in group BHA than group PFNA at three months postoperatively (P < 0.05), but there was no significant difference between the two groups at 6 and 12 months postoperatively (P > 0.05). There was no significant difference in postoperative complications between the two groups (P > 0.05).

Conclusion
The BHA allows an earlier return to weight-bearing activity, but ultimately has the same effective treatments as the PFNA for the elderly with unstable comminuted ITFs.