bluuebunny/crossref_metadata_2025_split huggingface dataset:
A nomogram for evaluation and analysis of difficulty in retroperitoneal laparoscopic adrenalectomy: A single-center study with prospective validation using LASSO-logistic regression
Authors: Sun Shiwei , Wang Jinyao , Yang Bin , Wang Yue , Yao Wei , Yue Peng , Niu Xiangnan , Feng Anhao , Zhang Lele , Yan Liang , Cheng Wei , Zhang Yangang 
Published: November 2022

BackgroundWhile it is known that inaccurate evaluation for retroperitoneal laparoscopic adrenalectomy (RPLA) can affect the surgical results of patients, no stable and effective prediction model for the procedure exists. In this study, we aimed to develop a computed tomography (CT) -based radiological-clinical prediction model for evaluating the surgical difficulty of RPLA.MethodData from 398 patients with adrenal tumors treated by RPLA in a single center from August 2014 to December 2020 were retrospectively analyzed and divided into sets. The influencing factors were selected by least absolute shrinkage and selection operator regression model (LASSO). Additionally, the nomogram was constructed. A receiver operating characteristic curve was used to analyze the prediction efficiency of the nomogram. The C-index and bootstrap self-sampling methods were used to verify the discrimination and consistency of the nomogram.ResultThe following 11 independent influencing factors were selected by LASSO: body mass index, diabetes mellitus, scoliosis, hyperlipidemia, history of operation, tumor diameter, distance from adrenal tumor to upper pole of kidney, retro renal fat area, hyperaldosteronism, pheochromocytoma and paraganglioma, and myelolipoma. The area under the curve (AUC) of the training set was 0.787, and 0.844 in the internal validation set. Decision curve analyses indicated the model to be useful. An additional 117 patients were recruited for prospective validation, and AUC was 0.848.ConclusionThis study developed a radiological-clinical prediction model proposed for predicting the difficulty of RPLA procedures. This model was suitable, accessible, and helpful for individualized surgical preparation and reduced operational risk. Thus, this model could contribute to more patients’ benefit in circumventing surgical difficulties because of accurate predictive abilities.
MicroRNA cerebrospinal fluid profile during the early brain injury period as a biomarker in subarachnoid hemorrhage patients
Authors: Pedrosa Leire , Hoyos Jhon , Reyes Luis , Llull Laura , Santana Daniel , de Riva Nicolás , Mellado Ricard , Sala Xavier , Rodríguez-Hernández Ana , Enseñat Joaquim , Amaro Sergio , Torné Ramon 
Published: November 2022

IntroductionDelayed cerebral ischemia (DCI) is a dreadful complication present in up to 30% of patients with spontaneous subarachnoid hemorrhage (SAH). Indeed, DCI is one of the main causes of long-term disability in SAH, yet its prediction and prevention are troublesome in poor-grade SAH cases. In this prospective study, we explored the potential role of micro ribonucleic acid (microRNA, abbreviated miRNAs)—small non-coding RNAs involved in clue gene regulation at the post-transcriptional level—as biomarkers of neurological outcomes in SAH patients.MethodsWe analyzed the expression of several miRNAs present in the cerebrospinal fluid (CSF) of SAH patients during the early stage of the disease (third-day post-hemorrhage). NanoString Technologies were used for the characterization of the CSF samples.ResultsWe found an overexpression of miRNAs in the acute stage of 57 SAH in comparison with 10 non-SAH controls. Moreover, a differential expression of specific miRNAs was detected according to the severity of clinical onset, but also regarding the development of DCI and the midterm functional outcomes.ConclusionThese observations reinforce the potential utility of miRNAs as prognostic and diagnostic biomarkers in SAH patients. In addition, the identification of specific miRNAs related to SAH evolution might provide insights into their regulatory functions of pathophysiological pathways, such as the TGF-β inflammatory pathway and blood-brain barrier disruption.
Oxygen-enriched oleic matrix (NovoX) for wound healing in pediatric patients undergoing open surgical treatment for pilonidal disease: Preliminary experience
Authors: Bisol Marta , Tykhomyrova Sophia , Pagliara Camilla , Scarpa Maria-Grazia , Guida Edoardo , Olenik Damiana , Codrich Daniela , Schleef Jürgen , Boscarelli Alessandro 
Published: November 2022

IntroductionPilonidal disease (PD) is a common infectious and inflammatory condition affecting the gluteal cleft and sacrococcygeal region. The optimal treatment for PD remains controversial. While the open technique reduces the number of relapses compared to minimally invasive approaches, it is associated with a longer healing time. Reactive oxygen species are a key part of the normal wound-healing process. Herein, we reported our preliminary experience using a new oxygen-enriched oil-based product called NovoX for wound healing after open surgery for PD.Materials and methodsWe used a new oxygen-enriched product for wound healing in three pediatric patients undergoing open surgical repair for PD between December 2021 and April 2022. During postoperative follow-up, healing time and the aesthetic result were evaluated.ResultsOur preliminary study included three patients with chronic PD. The average follow-up time was 5 weeks, corresponding to the end of the healing process and the resumption of normal daily activities. Only one mild complication occurred during the study period. No short-term side effects were reported. The cosmetic result was reported as satisfactory.ConclusionNovoX is easy to apply, safe, and effective for treating pediatric patients undergoing open surgical treatment for PD, leading to slightly faster wound healing with good aesthetic outcomes.
The association of gabapentin initiation and neurocognitive changes in older adults with normal cognition
Authors: Oh GYeon , Moga Daniela C. , Fardo David W. , Abner Erin L. 
Published: November 2022

Background: Gabapentin is increasingly prescribed to older adults, which raises concerns about its potential to cause neurocognitive changes. Therefore, we aimed to examine the association of gabapentin use with neurocognitive changes (i.e., cognitive decline, functional status decline, and motor function change) in older adults.Methods: We conducted a retrospective cohort study using the National Alzheimer’s Coordinating Center Uniform Data Set (UDS; September 2005-March 2021 data freeze). From the eligible sample (≥age 65 years), we identified cognitively normal new-users of gabapentin and the visit they initiated gabapentin (i.e., index visit). Initiators were matched to randomly selected nonusers on year of UDS enrollment and visit number from enrollment to index. Cognitive decline was defined as any increase in the Clinical Dementia Rating global score (CDRGLOB) and as a 1-point increase in CDR sum of boxes (CDR-SB). Functional status decline was defined as a 3-point increase in the sum of the Functional Activities Questionnaire (FAQ) and as 0.3-point increase in mean FAQ. Decline in motor function was defined as new clinician reports of gait disorder, falls, and slowness. To mitigate confounding and selection bias, we used joint stabilized inverse probability of treatment weights and stabilized inverse probability of censoring weights. All analyses were conducted comparing index to index+1 and index+2 visits.Results: From the eligible UDS participants (N = 23,059), we included 480 initiators (mean age [SD]: 78.7 [6.9]; male 34.4%); 4,320 nonusers (78.3 [7.0]; 34.4%). Gabapentin initiation was significantly associated with cognitive/functional status decline: worsening CDRGLOB at index+1 visit (odds ratio [95% confidence interval]: 1.55 [1.07, 2.25]); CDR-SB at index+1 visit (1.94 [1.22, 3.09]); and mean of FAQ at index+2 visit (1.78 [1.12, 2.83]). After excluding initiators with extant motor dysfunction (n = 21), we identified 459 initiators (78.7 [6.9]; 34.0%) and 4,131 nonusers (78.2 [6.9]; 34.7%); in this sample, gabapentin initiation was associated with increased falls at the index+2 visit (2.51 [1.19, 5.31]).Conclusion: Gabapentin initiation was significantly associated with deleterious neurocognitive changes among older adults with initially normal cognition. Further studies are needed to examine the risk/benefit of prescribing gabapentin in older adults.
Role of AMPK in autophagy
Authors: Wang Shengyuan , Li Hongyan , Yuan Minghao , Fan Haixia , Cai Zhiyou 
Published: November 2022

Adenosine monophosphate-activated protein kinase (AMPK) is a significant energy sensor in the maintenance of cellular energy homeostasis. Autophagy is a highly conserved catabolic process that involves an intracellular degradation system in which cytoplasmic components, such as protein aggregates, organelles, and other macromolecules, are directed to the lysosome through the self-degradative process to maintain cellular homeostasis. Given the triggered autophagy process in various situations including the nutrient deficit, AMPK is potentially linked with different stages of autophagy. Above all, AMPK increases ULK1 activity by directly phosphorylating Ser467, Ser555, Thr574, and Ser637 at least four sites, which increases the recruitment of autophagy-relevant proteins (ATG proteins) to the membrane domains which affects autophagy at the initiation stage. Secondly, AMPK inhibits VPS34 complexes that do not contain pro-autophagic factors and are thus involved in isolation membrane forming processes, by direct phosphorylation of VPS34 on Thr163 and Ser165. After phosphorylation, AMPK can govern autophagosome formation through recruiting downstream autophagy-related proteins to the autophagosome formation site. Finally, the AMPK-SIRT1 signaling pathway can be activated by upregulating the transcription of autophagy-related genes, thereby enhancing autophagosome-lysosome fusion. This review provides an introduction to the role of AMPK in different stages of autophagy.
Attention to food cues following media multitasking is associated with cross-sectional BMI among adolescents
Authors: Brand John , Carlson Delaina , Ballarino Grace , Lansigan Reina Kato , Emond Jennifer , Gilbert-Diamond Diane 
Published: November 2022

PurposeTo measure attention to food cues following a multitask or a sustained attention single task, and further, to examine the associations with current weight status and excess consumption.MethodsNinety-six 13-to 17-year-olds were fed a standardized meal and then had their attention to food cues measured following completion of a single sustained attention task, media multitask, or a passive viewing control task. Participants then completed an eating in the absence of hunger paradigm to measure their excess consumption. Adolescents completed each condition on separate visits in randomized order. Attention to food cues was measured by computing eye-tracking measures of attention, first fixation duration, and cumulative fixation duration to distractor images while participants played the video game, Tetris. Participants also had their height and weight measured.ResultsAlthough not statistically significant, attention to food cues was greatest following a media multitask and weakest following a task that engaged sustained attention when compared to a control. First fixation duration was positively and statistically significantly associated with BMI-Z when measured following a multitask. Cumulative fixation duration was not associated with BMI-Z. There were no associations between BMI-Z and attention to food cues after the attention or control task, nor any association between attention to food cues and eating in the absence of hunger.ConclusionAmong adolescents, we found that current adiposity was related to attention to food cues following a multitask. Multitasking may perturb the cognitive system to increase attention to food cues.
Self-reported narcissistic traits in patients with addiction through the lens of the ICD-11 model for personality disorders
Authors: Riegel Karel D. , Schlosserova Lucia , Zbornik Tadeas S. 
Published: November 2022

BackgroundThere is a presumption that pathological narcissism, or narcissistic personality disorder per se, can be considered a precursor to addiction. Although the ICD-11 model does not distinguish specific personality disorders, narcissistic psychopathology should be captured through personality trait qualifiers.ObjectivesTo verify the capacity of the ICD-11 model in the detection of narcissistic psychopathology in patients with addiction; to test its discrimination capacity, convergent validity, and specificity toward the gender and the type of addiction.Materials and methodsTwo samples were employed in the study. Sample 1 (n = 421) consisted of patients with addiction; Sample 2 (n = 567) consisted of general population volunteers. Age range was 18–75 years and a battery of self-assessment questionnaires containing Personality Inventory for DSM-5–Brief Form Plus Modified; Triarchic Psychopathy Measure; Hypersensitive Narcissism Scale; and Level of Personality Functioning Scale-Self-Report was administered by pencil-and-paper method.ResultsThe following was confirmed: (1) capacity of the ICD-11 model in relation to capture narcissistic pathology; (2) the differentiation capacity between the clinical and non-clinical population; (3) gender specificity in relation to grandiose and vulnerable narcissism; (4) the connection between the overall degree of impairment in personality functioning and most of trait qualifiers; (5) certain specifics of patients with addiction in relation to the type of addiction.ConclusionResults support the empirical and clinical relevance of the ICD-11 model in capturing narcissistic pathology in addicted patients. Clinical implications concerning assessment and treatment in addiction settings, and certain limits regarding the Anankastia domain are discussed.
Evaluation of psychometric properties of dietary habits, lifestyle, food frequency consumption, and nutritional beliefs (KomPAN) questionnaire in Iranian adults
Authors: Saadati Kiyana , Chaboksavar Fakhreddin , Jahangasht Ghoozlu Khadije , Shamsalinia Abbas , Kordbageri Mohammad Reza , Ghadimi Reza , Porasgari Zeinab , Ghaffari Fatemeh 
Published: November 2022

BackgroundAdherence to unhealthy dietary patterns is a major cause of overweight and obesity in adults. Therefore, it is recommended that assessment and modification of unhealthy lifestyle should be included in prevention programs. To achieve this goal, it is necessary to evaluate the status of dietary patterns in adults with valid and reliable tools. Thus, the aims of the present study were to translate the KomPAN questionnaire, evaluate its psychometric properties in Iranian adults and measure 4 dietary indices including high-saturated-fats-Diet-Index-8 (hSFDI-8), high-Sugar- Diet-Index-4 (hSDI-4), low-Glycaemic-Diet-Index-4 (LGIDI-4) and high- Glycaemic-Diet-Index-7 (hGIDI-7) based on 3 groups of body mass index (BMI) (BMI = 18.5–24.9, BMI = 25–29.9 and BMI ≥ 30), gender, educational level, income status, and age.MethodsThe KomPAN questionnaire included 4 scales nutrition beliefs (NB), lifestyle, food frequency consumption (FFC), dietary habits (DH) and after its translation from English into Persian, the psychometric properties of all 4 scales (face and content validity) were evaluated. For both FFC and NB scales, the construct validity was assessed through exploratory factor analysis (EFA), confirmatory factor analysis (CFA) and convergent and discriminant validity, the internal consistency was evaluated using the Cronbach's alpha coefficient, McDonald's omega (Ω) and Theta coefficient (θ), as well as the stability was assessed via intraclass correlation coefficient (ICC). Cross-classification and Kappa statistics were evaluated for both DH and lifestyle scales. Then, 4 dietary indices were measured in terms of demographic variables.ResultsThe cross-classification of DH (93.96%) and lifestyle (95.87%) scales indicated the percentage of correct classification in the test-retest scales. The Kappa statistic was &gt;0.4 and its value was acceptable. The mean Kappa statistics were 0.734 and 0.865 for the DH and lifestyle scales, respectively. The fit indices showed that the two-factor construct of the FFC scale and the one-factor construct of the NB scale had a good and acceptable fit among the Iranian adults. The FFC and NB scales had acceptable internal consistency and stability.ConclusionIt is recommended that other researchers use the KomPAN questionnaire to identify DH, FFC, NB and lifestyle as well as measure diet quality scores in the adult community.
Shift work is significantly and positively associated with possible gastro-esophageal reflux disease: A meta-analysis study
Authors: Chen Hsiang-Tai , Chuang Hung-Yi , Hsieh Tsung-Yu , Wu Pei-Shan , Lin Fang-Jiun , Huang Huan-Chih , Yang Chen-Cheng , Kuo Chao-Hung 
Published: November 2022

BackgroundOne of the health issues related to shift work patterns is possible gastro-esophageal reflux disease (GERD) symptoms. However, the association between shift work and possible GERD symptoms through meta-analysis has not been developed in the current literature field. Therefore, the purpose of this study is to analyze the association between shift work and possible GERD symptoms through meta-analysis.MethodsStudies containing target keywords were found in three datasets, and four articles were selected for further analysis after examining the title, abstract, and text. All prevalence odds ratios (ORs) among different groups of the population and the standard error (SE) from each included study were calculated for conducting meta-analysis.ResultThe pooled OR has shown a significant positive association between shift work and possible GERD (OR 1.53; 95% confidence interval [CI] 1.33–1.77, p-value 0.003). Compared to non-shift workers, the subgroup analysis indicates there are positive associations between possible GERD and the night shift (OR 1.39; 95% CI 1.16–1.66), and the rotating shift (OR 1.83; 95% CI 1.44–2.33). The subgroup analysis has also shown similar trends in shift working men (OR 1.28; 95% CI 1.03–1.60) and shift workers of both genders (OR 1.75; 95% CI 1.45–2.11).ConclusionThis study has shown a positive association between shift work and possible GERD.
Avaliação de confiabilidade das medidas dentárias mesio-distais entre modelos digitais e tradicionais
Authors: Tuma Carlos Eduardo da Silva Nossa , Dos Santos José Ricardo Prando , Lima Aniele Cristina Pereira , Correa Sabrina Elora de Almeida 
Published: November 2022

Os modelos de estudo propiciam uma imagem tridimensional dos arcos dentários e são imprescindíveis para o ortodontista e cirurgião dentista, auxiliando no diagnóstico e planejamento nas mais diversas especialidades. Os modelos podem ser de gesso convencionais, já consagrados dentro da clínica odontológica e com os avanços tecnológicos surgiram os modelos digitais obtidos através de escaneamento intrabucal, com isso, as análises de modelo, antes realizadas com paquímetros e compassos de ponta seca, agora são realizadas com o auxílio de softwares. A utilização dos modelos digitais vem sendo ampliada, sendo uma excelente ferramenta para o ensino e pesquisa, porém esse recurso ainda é pouco explorado, muitas vezes em virtude da falta de conhecimento de suas vantagens , e com isso, o uso de modelos digitais tem gerado controvérsias quanto a confiabilidade de resultados. Este trabalho objetivou relatar as vantagens e desvantagens da utilização de modelos digitais e fazer uma análise da confiabilidade e reprodutibilidade dos mesmos.
EDUCAR PARA A TOLERÂNCIA RELIGIOSA NAS ESCOLAS PÚBLICAS
Authors: Salaroli Tatiane Pereira 
Published: November 2022

Este trabalho tem como objetivo desenvolver uma reflexão evolvendo educação escolar e intolerância religiosa nas escolas. A diversidade e a intolerância religiosa, dois temas presentes na sociedade brasileira que exigem mais atenção ao serem discutidos no âmbito escolar. É necessário abordar essa temática na escola e nas salas de aula, visto que a demonstração e os atos de intolerância fazem partes da realidade social vivida hoje por muitos dentro ou fora dos muros da escola. Através de uma revisão bibliográfica, este artigo busca debater o contexto da intolerância religiosa no Brasil especificamente nas salas de aula, ressaltar a conduta dos profissionais da educação frente à intolerância e quais os empecilhos encontrados para combate-la, além de apresentar propostas que contribuem para a promoção do reconhecimento da diversidade religiosa, propondo formas alternativas para trabalhar conteúdos didáticos com abordagens temáticas sobre essa diversidade no intuito de promover o respeito às diferenças.Palavras chave: Religião; Intolerância; Educação; Diversidade.
A EXPANSÃO DO PENTECOSTALISMO NA CIDADE DE FEIRA DE SANTANA, BA: A IGREJA EVANGÉLICA AVIVAMENTO BÍBLICO
Authors: Nascimento Valdivan Conceição 
Published: November 2022

Neste texto analisamos a formação da Igreja Evangélica Avivamento Bíblico na cidade de Feira de Santana, destacando os antecedentes históricos, personagens mais importantes e os fatos marcantes que deram origem a essa igreja pentecostal. A fim de refletir sobre a participação da IEAB para a expansão do pentecostalismo na cidade, resgatamos os fatos históricos da inserção do protestantismo e, posteriormente, do pentecostalismo no campo religioso feirense. Apresentamos o processo através do qual se deu a fundação da IEAB a nível nacional e especificamente na cidade de Feira de Santana, destacando a característica do protestantismo brasileiro de originar novas igrejas a partir de divisões ou fusões.
O NEOPENTECOSTALISMO E A INTOLERÂNCIA RELIGIOSA PRATICADA CONTRA AS RELIGIÕES AFRO-BRASILEIRAS
Authors: Santos Murilo Silva 
Published: November 2022

A intolerância religiosa tem sido um dos problemas amplamente discutidos na contemporaneidade, dado os diversos casos de violência que são apresentados constantemente na mídia. Este artigo tem por objetivo elucidar a questão da intolerância religiosa, principalmente a praticada por neopentecostais aos adeptos das religiões afrodescendentes, sendo este um problema social e que deve ser combatido, visto que ao desrespeitar a liberdade religiosa, tem se desrespeitado a pluralidade existente em nosso país. Esse que é considerado laico, a intolerância religiosa não deveria ser um problema, pois somos multifacetados em nossa maneira de pensar, e isso vale também para as nossas crenças, por isso, o respeito às diferenças é um tema a ser discutido e essencial à convivência em sociedade.
O CRITÉRIO DE VERDADE NO DIÁLOGO DO CONTRA ACADÊMICOS DE AGOSTINHO: UMA HERMENÊUTICA DAS REFUTAÇÕES DE AGOSTINHO AO CETICISMO ACADÊMICO
Authors: Alves Lion Granier 
Published: November 2022

A proposta do artigo procura discorrer sobre a problemática dos critérios de verdade no diálogo do Contra os Acadêmicos de Agostinho de Hipona (354-430). Através da análise dos textos da obra, será proposta a reflexão a partir da indagação: pode o homem alcança a felicidade e sabedoria enquanto peregrina a procura da verdade? Será analisada a proposta do ceticismo acadêmico, a partir das escolas helenísticas, a saber: Acadêmica e Estóa, a partir do proposta das duas escolas, será apresento um panorama introdutório dos conceitos e fundamentos que os movimentos filosóficos apresentam sobre os critérios de verdade. Nesta busca, Agostinho compreende que o homem necessita conhecer a si mesmo e buscar a Deus para alcançar a verdade. Com o tema verdade, o filósofo ratifica que o homem necessita ter em si algo eterno, portanto conhecer ao Deus que habita em seu interior.