bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationships Between Bronchodilators, Steroids, Antiarrhythmic Drugs, Antidepressants, and Benzodiazepines and Heart Disease and Ischemic Stroke in Patients With Predominant Bronchiectasis and Asthma
Authors: Yeh Jun-Jun , Lai Mei-Chu , Yang Yu-Cih , Hsu Chung-Y. , Kao Chia-Hung 
Published: February 2022

ObjectiveWe investigated the effects of medication on heart disease and ischemic stroke (HDS) risk in patients with predominant bronchiectasis-asthma combination (BCAS).MethodsBCAS and non-BCAS cohorts (N = 588 and 1,118, respectively) were retrospectively enrolled. The cumulative incidence of HDS was analyzed using Cox proportional regression; propensity scores were estimated using non-parsimonious multivariable logistic regression. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for HDS were calculated, adjusting for sex, age, comorbidities, and medication {long- and short-acting β2 agonists and muscarinic antagonists (LABAs/SABAs and LAMAs/SAMAs), steroids [inhaled corticosteroid steroids (ICSs), oral steroids (OSs)], antiarrhythmics, antidepressants (fluoxetine), benzodiazepines (alprazolam, fludiazepam), statins and antihypertensive drugs (diuretics, cardioselective beta blockers, calcium channel blockers (CCBs) and angiotensin converting enzyme inhibitors (ACEi), angiotensin II blockers)}.ResultsCompared with the non-BCAS cohort, the BCAS cohort taking LABAs, SABAs, SAMAs, ICSs, OSs, antiarrhythmics, and alprazolam had an elevated HDS risk [aHRs (95% CIs): 2.36 (1.25–4.33), 2.65 (1.87–3.75), 2.66 (1.74–4.05), 2.53 (1.61–3.99), 1.76 (1.43–2.18), 9.88 (3.27–30.5), and 1.73 (1.15–2.58), respectively except fludiazepam 1.33 (0.73–2.40)]. The aHRs (95% CIs) for LABAs ≤ 30 days, DDDs &lt;415, ICSs ≤ 30 days were 1.10 (0.38–3.15), 2.95 (0.22–38.8), 1.45 (0.76–2.77). The aHRs (95% CIs) for current and recent alprazolam were 1.78 (1.09–2.93) and 777.8 (1.34–451590.0); for current and past fludiazepam were 1.39 (0.75–2.59) and 1.29 (0.42–4.01) and for past alprazolam was 1.57 (0.55–4.46); respectively. The aHRs (95% CIs) for alprazolam &gt;30 DDDs, fludiazepam &gt;20 DDDs, ICSs ≦415 DDDs, and OSs DDDs ≦15 were 1.60 (0.78–3.29), 2.43 (0.90–6.55), 5.02 (1.76–14.3), and 2.28 (1.43–3.62), respectively.ConclusionThe bronchodilators, steroids, and antiarrhythmics were associated with higher risk of HDS, even low dose use of steroids. However, the current use of LABAs/ICSs were not associated with HDS. Benzodiazepines were relatively safe, except for current or recent alprazolam use. Notably, taking confounders into account is crucial in observational studies.
Antimicrobial Activity of Remineralizing Ion-Doped Amorphous Calcium Phosphates for Preventive Dentistry
Authors: Degli Esposti Lorenzo , Ionescu Andrei C. , Carella Francesca , Adamiano Alessio , Brambilla Eugenio , Iafisco Michele 
Published: February 2022

We have synthesized citrate-stabilized amorphous calcium phosphates doped with fluoride (F-ACP), strontium (Sr-ACP), and zinc (Zn-ACP) ions. ACP based materials were proven to have excellent remineralizing action on demineralized dental hard tissues while F−, Sr2+, and Zn2+ ions are known to have antimicrobial activity, so the aim of our work was to produce multipurpose materials for preventive dentistry that inhibit cariogenic bacteria and remineralize dental enamel and dentin. Doping ions were successfully incorporated into ACP up to 2 wt.% F− and 12 wt.% Sr2+ or Zn2+ without altering ACP physical-chemical properties. Evaluation of viability of Streptococcus Mutans biofilm treated with ion-doped ACP materials showed that F-ACP and Sr-ACP have a direct inhibitory effect while Zn-ACP has a negligible effect. The different antibacterial activity was correlated to the ion-release properties of the materials, as in conditions mimicking a cariogenic environment F-ACP and Sr-ACP have a release of ca. 5–7% of total F− or Sr2+ while only ca. 1% of total Zn2+ is released. All ion-doped ACP materials are able to remineralize in vitro demineralized human enamel slabs by epitaxial deposition of a new ion-doped crystalline phase in direct contact with the pristine one. Enamel slabs remineralized with F-ACP has an antibacterial/bacteriostatic action, proving that F-ACP acts as preventive antimicrobial agent. Overall, our work demonstrates the high potential of ACP doped with antibacterial ions for the preventive treatment of dental caries.
Reintubation Summation Calculation: A Predictive Score for Extubation Failure in Critically Ill Patients
Authors: Bansal Vikas , Smischney Nathan J. , Kashyap Rahul , Li Zhuo , Marquez Alberto , Diedrich Daniel A. , Siegel Jason L. , Sen Ayan , Tomlinson Amanda D. , Venegas-Borsellino Carla P. , Freeman William David 
Published: February 2022

ObjectiveTo derive and validate a multivariate risk score for the prediction of respiratory failure after extubation.Patients and methodsWe performed a retrospective cohort study of adult patients admitted to the intensive care unit from January 1, 2006, to December 31, 2015, who received mechanical ventilation for ≥48 h. Extubation failure was defined as the need for reintubation within 72 h after extubation. Multivariate logistic regression model coefficient estimates generated the Re-Intubation Summation Calculation (RISC) score.ResultsThe 6,161 included patients were randomly divided into 2 sets: derivation (n = 3,080) and validation (n = 3,081). Predictors of extubation failure in the derivation set included body mass index &lt;18.5 kg/m2 [odds ratio (OR), 1.91; 95% CI, 1.12–3.26; P = 0.02], threshold of Glasgow Coma Scale of at least 10 (OR, 1.68; 95% CI, 1.31–2.16; P &lt; 0.001), mean airway pressure at 1 min of spontaneous breathing trial &lt;10 cmH2O (OR, 2.11; 95% CI, 1.68–2.66; P &lt; 0.001), fluid balance ≥1,500 mL 24 h preceding extubation (OR, 2.36; 95% CI, 1.87–2.96; P &lt; 0.001), and total mechanical ventilation days ≥5 (OR, 3.94; 95% CI 3.04–5.11; P &lt; 0.001). The C-index for the derivation and validation sets were 0.72 (95% CI, 0.70–0.75) and 0.72 (95% CI, 0.69–0.75). Multivariate logistic regression demonstrated that an increase of 1 in RISC score increased odds of extubation failure 1.6-fold (OR, 1.58; 95% CI, 1.47–1.69; P &lt; 0.001).ConclusionRISC predicts extubation failure in mechanically ventilated patients in the intensive care unit using several clinically relevant variables available in the electronic medical record but requires a larger validation cohort before widespread clinical implementation.
Single Dose Gonadotropin-Releasing Hormone Agonist Luteal Support in Fresh Embryo Transfer: Variation in Timing, Type, and Dosage
Authors: Abu Muhammad Azrai , Alexander Jojinah Vindah , Abdul Karim Abdul Kadir , Ahmad Mohd Faizal , Omar Mohd Hashim 
Published: February 2022

ObjectivesTo evaluate the effects of the addition of single-dose GnRH agonist to the routine progestogens use for luteal phase support on IVF outcome as compared to progestogens only.MethodsThis is a retrospective case-control study on selected patients who underwent IVF treatment with fresh embryo transfer (ET) under Medically Assisted Conception Unit, University Kebangsaan Malaysia Medical Center for the period of June 2015–June 2018. A higher dose of 0.2 mg subcutaneous Decapeptyl was administered 2 days before fresh ET concurrent with routine progestogen support. Patients with different luteal phase regimes, frozen embryo transfer and medical records with missing data were excluded. Their medical records were reviewed, and data analyzed. The pregnancy outcomes measured included biochemical pregnancy rates, clinical pregnancy rates, live birth rates and miscarriage rates.ResultsA total of 786 patients were analyzed. Four hundred forty-four patients were given luteal phase support with progestogens and GnRH agonist, whereas 342 patients served as control were given progestogens only. The study group showed higher biochemical pregnancy rate (47.7 vs. 44.4%,), clinical pregnancy rate (25.7 vs. 23.4%) and livebirth rate (24.3 vs. 22.2%), respectively but not statistically significant. The rate of miscarriage among the study group was lower (4.5% vs 9.4%) compared to the progestogen group alone. Nonetheless, the OHSS rate was slightly increased in the study group (4.5 vs. 3.5%) despite using a mild stimulation protocol.ConclusionsNew regime of GnRH agonist luteal support in addition to the standard progestogen support was found to be beneficial in overall IVF outcome.
Dietary Patterns Are Associated With Multi-Dimensional Cognitive Functions Among Adults Aged 55 and Older in China
Authors: Huang Qiumin , Jiang Hongru , Zhang Jiguo , Jia Xiaofang , Huang Feifei , Wang Huijun , Zhang Bing , Wang Liusen , Gu Minxia , Huang Yuelong , Shi Wei , Ma Yuxia , Zhang Xinjing , Wang Zhihong 
Published: February 2022

BackgroundThe intake of certain food and nutrients may play a crucial role in cognitive health. However, research on the relationship between dietary patterns and cognitive function is limited. This study aims to investigate the associations between dietary patterns and multi-dimensional cognitive functions, such as global cognitive status and related domain profiles, mild cognitive impairment (MCI), and four major subtypes of Chinese adults.MethodsUsing the baseline data from the Community-based Cohort Study on Nervous System Diseases (2018–2019), we selected 4,309 Chinese adults aged 55 years and older as subjects with complete diet, cognition, and other related data. We collected food data for the past 12 months with a valid semi-quantitative food frequency questionnaire. Diving 49 food items into 13 subgroups, we used factor analysis to derive the main dietary patterns. We evaluated cognitive functions based on the scores of the Montreal Cognitive Assessment (MoCA) and used quantile regression and multivariable logistic regression to examine the relationship between dietary patterns and cognitive-related outcomes.ResultsWe identified four dietary patterns, explaining 50.11% of the total variance: “meat-preferred” pattern, “plant-preferred” pattern, “eggs- and dairy-preferred” pattern, and “grain-preferred” pattern. After adjusting for all potential confounders, the “meat-preferred” pattern and the “plant-preferred” pattern were associated with higher scores of global cognition and several cognitive domains (p &lt;0.05), while the “grain-preferred” pattern was associated with lower scores of global cognition (β = −0.36, p &lt;0.05), execution (β = −0.19, p &lt;0.05), visuospatial (β = −0.09, p &lt;0.05), and language (β = −0.05, p &lt;0.05). Adults adhering to the “meat-preferred” pattern and the “plant-preferred” pattern had decreased odds of MCI and some MCI subtypes (p-trend &lt;0.05); in contrast, those in the top quartiles of the “grain-preferred” pattern had increased odds of MCI [adjusted odds ratio (AOR) = 1.34, 95% CI: 1.11–1.63, p-trend = 0.003].ConclusionsAdhering to the “plant-preferred” pattern and the “meat-preferred” pattern may help improve the multi-dimensional cognitive functions; on the contrary, adhering to the “grain-preferred” pattern may worse cognitive health. More prospective studies in this field are needed to strengthen the evidence.
The Effects of Lutein and Zeaxanthin Supplementation on Cognitive Function in Adults With Self-Reported Mild Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Study
Authors: Lopresti Adrian L. , Smith Stephen J. , Drummond Peter D. 
Published: February 2022

BackgroundLutein and zeaxanthin are fat-soluble, dietary carotenoids with high concentrations in human brain tissue. There have been a number studies confirming an association between lutein and zeaxanthin and cognitive function.PurposeExamine the effects of lutein and zeaxanthin supplementation on cognitive function in adults with self-reported cognitive complaints.Study DesignTwo-arm, parallel-group, 6-month, randomized, double-blind, placebo-controlled trial.MethodsNinety volunteers aged 40–75 years received either 10 mg of lutein and 2 mg of zeaxanthin, once daily or a placebo. Outcome measures included computer-based cognitive tasks, the Cognitive Failures Questionnaire, Behavior Rating Inventory of Executive Function, Profile of Mood States, and the Patient-Reported Outcomes Measurement Information System-29.ResultsCompared to the placebo, lutein and zeaxanthin supplementation was associated with greater improvements in visual episodic memory (p = 0.005) and visual learning (p = 0.001). However, there were no other statistically-significant differences in performance on the other assessed cognitive tests or self-report questionnaires. Lutein and zeaxanthin supplementation was well-tolerated with no reports of significant adverse effects.ConclusionThe results from this trial suggest that 6-months of supplementation with lutein and zeaxanthin may improve visual memory and learning in community-dwelling adults with self-reported cognitive complaints. However, it had no other effect on other computer-based measures of cognitive performance or self-report measures of cognition, memory, mood, or physical function.
Case Report: Chemotherapy and Radiotherapy Combined With DC-CIK for Pulmonary and Mediastinal Metastases From Nasopharyngeal Carcinoma
Authors: Gan Yi-Xiu , Li Gui-Hua , Ou Xue , Wang Chun-Hui , Du Qing-Hua 
Published: February 2022

IntroductionThe optimal treatment for pulmonary and mediastinal metastasis of nasopharyngeal carcinoma (NPC) is still controversial, and the therapeutic effect is poor recently. In one case, we demonstrated a long-term survival after postoperative chemoradiotherapy combined with dendritic cell and cytokine-induced killer (DC-CIK) immunotherapy for pulmonary and mediastinal metastases from NPC.Baseline CharacteristicsA 53-year-old woman was admitted to our hospital in June 2008. Pathological biopsy revealed a poorly differentiated squamous cell carcinoma located in the nasopharynx with the invasion of internal pterygoid muscles, the sphenoid bone, and unilateral neck lymph node metastasis. No distant metastases were observed. The stage of NPC was T3N1M0 III (AJCC8). The patient received concurrent chemoradiotherapy for primary lesion and neck lymph nodes and achieved complete remission (CR) of the disease after 3 months. Follow-up at 3-month intervals was carried out. Pulmonary and mediastinal lymph node metastases were found in July 2009. The patient then underwent right upper lobectomy and mediastinal lymph node dissection and five cycles of gemcitabine and cisplatin (GP) regimen chemotherapy, following radiotherapy and DC-CIK immunotherapy.ResultsAfter a follow-up time of 13 years, no tumor recurrence or metastasis and severe adverse reactions were found.ConclusionPostoperative chemotherapy and radiotherapy in combination with DC-CIK immunotherapy may produce a synergistic therapeutic effect on patients with mediastinal lymph node metastasis from NPC.
Long Non-Coding RNA AL513318.2 as ceRNA Binding to hsa-miR-26a-5p Upregulates SLC6A8 Expression and Predicts Poor Prognosis in Non-Small Lung Cancer
Authors: Fan Yongfei , Zhou Yong , Li Xinwei , Lou Ming , Gao Zhaojia , Yuan Kai , Tong Jichun 
Published: February 2022

BackgroundStudies have demonstrated that the regulatory role of competitive endogenous RNA (ceRNA) networks is closely related to tumorigenesis, which provides new targets for tumor therapy. In this study, the focus was to explore the ceRNA networks that regulate SLC6A8 expression and their prognosis in non-small cell lung cancer (NSCLC).MethodsFirstly, the Cancer Genome Atlas (TCGA) data combined with immunohistochemical staining was used to compare SLC6A8 expression in NSCLC tissues and normal tissues. Thereafter, samples from the immunohistochemical staining of NSCLC were integrated with clinical follow-up data for prognostic analysis. The Starbase database was employed to search for SLC6A8-targeted miRNAs and lncRNAs, and survival analysis was performed using clinical data from TCGA to obtain SLC6A8 expression and prognosis-related ceRNA networks. Finally, the prognostic and therapeutic prospects of SLC6A8 in NSCLC were further analyzed from methylation sites and the immune microenvironment.ResultsThe study results revealed that SLC6A8 was significantly overexpressed in NSCLC tissues compared to normal tissues, and clinical follow-up data showed that the overexpression group was associated with poor prognosis. In addition, the Starbase data combined with TCGA clinical data analysis demonstrated that the AL513318.2/hsa-miR-26a-5p/SLC6A8 network regulates SLC6A8 overexpression in NSCLC and is associated with poor prognosis. Methylation analysis revealed that 11 methylation sites were closely associated with the prognosis of NSCLC. In addition, the immune prognostic risk model showed that the high-risk group was associated with a poorer prognosis than the low-risk group, despite showing a better immunotherapy outcome.ConclusionIn summary, the AL513318.2/hsa-miR-26a-5p/SLC6A8 network upregulates SLC6A8 expression in NSCLC and is associated with poor prognosis. Therefore it may be a prognostic biomarker of NSCLC and a potential therapeutic target.
Abiraterone, Orteronel, Enzalutamide and Docetaxel: Sequential or Combined Therapy?
Authors: Chen Ming-kun , Liang Zhi-jian , Luo Dao-Sheng , Xue Kang-yi , Liao De-ying , Li Zheshen , Yu Yuzhong , Chen Zhe-Sheng , Zhao Shan-Chao 
Published: February 2022

Objective: To summarize the current therapeutic status using chemotherapeutic agent docetaxel and endocrine therapeutic agents (ARAT, abiraterone, orteronel or enzalutamide) for the treatment of metastatic castration-resistant prostate cancer (mCRPC), including sequential therapy and combined therapy, to promote the consensus on the optimal regimen for achieving superior treatment efficacy.Methods: Through literature search in PubMed, articles with the following relevant keywords were collected and anlyzed: CRPC, abiraterone, orteronel and enzalutamide, median survival, overall survival, prostate specific antigen (PSA), PSA response rate and median radiologic progression-free survival.Results: Fifty-eight articles were obtained and analyzed in this review. These articles included androgen axis-targeting agents after docetaxel, docetaxel after androgen axis-targeting agents, Triple sequential and combination therapy, covering four current drugs for mCRPC treatment: docetaxel, abiraterone, orteronel, and enzalutamide. It was found that there may be some cross-resistance between androgen axis-targeting agents, which will reduce the efficacy of subsequent drug treatment. Although neither of the studies of using combination therapy showed serious drug toxicity, the efficacy of sequential therapy was not as good as expected. Most adverse reactions after treatment were reported to be level 1–2.Conclusion: Based on the results of the current studies, abiraterone followed by enzalutamide treatment is the best sequential treatment for most docetaxel-naïve patients. This treatment achieves not only good OS, but also PFS and PSA response rates. In addition, for patients who have previously failed docetaxel treatment, enzalutamide is the best choice as the subsequent treatment.
Highly Efficient Dual-Beam Frequency Scanning Based on SSPPs With Parasitic Patch Array
Authors: Pan Bai Cao , Guo Ben Jian , Yu Ping , Cai Ben Geng , Dai Xi Wang , Luo Guo Qing 
Published: February 2022

A leaky-wave antenna (LWA) realizes radiation of travelling wave along guiding structures. Periodic modulation is an effective approach to turn non-radiating modes into radiating modes. A high-efficient LWA based on spoof surface plasmon polaritons (SSPPs) loaded with parasitic patch array is proposed. Sinusoidal modulation is used for the radiation of SSPPs, while parasitic array mitigates the open stopband (OSB) effect. A prototype is fabricated and measured. The measured and simulated results agree well with each other. Such design shows wide angle coverage of 83° from backward to forward and stable gain distribution of about 12 dB within the whole operating band.
Active Engagement, Protective Buffering, and Depressive Symptoms in Young-Midlife Couples Surviving Cancer: The Roles of Age and Sex
Authors: Lyons Karen S. , Gorman Jessica R. , Larkin Brandon S. , Duncan Grace , Hayes-Lattin Brandon 
Published: February 2022

ObjectiveCancer researchers have found midlife couples to have poorer outcomes compared to older couples due to the off-time nature of the illness for them. It is unknown if young couples (aged 18–39), who are under-represented in cancer studies and overlooked for supportive programs, are at further risk. This study explored the moderating roles of survivor age and sex on the associations between active engagement and protective buffering and depressive symptoms in couples surviving cancer.MethodsThe exploratory study comprised 49 couples (aged 27–58) 1–3 years post-diagnosis. Multilevel modeling was used to explore the moderating roles of survivor age and sex, controlling for interdependent data.ResultsApproximately, 37% of survivors and 27% of partners met clinical criteria for further assessment of depression, with 50% of couples having at least one member meeting the criteria. Survivors and their partners did not significantly differ on depressive symptoms, active engagement, or protective buffering. Male survivors reported significantly higher levels of active engagement by their partners than female survivors and female survivors reported significantly higher levels of protective buffering by their partners than male survivors. We found some evidence to suggest that survivor age and sex may play moderating roles between active engagement and protective buffering and depressive symptoms. Older partners and female survivors appeared to experience more positive effects from engaging in positive dyadic behaviors than younger partners and male survivors.ConclusionFindings not only confirm the important role of dyadic behaviors for couples surviving cancer together, but also the important roles of survivor age and sex may play in whether such behaviors are associated with lower levels of depressive symptoms. Future research that examines these complex associations over time and across the adult life span in diverse populations is needed.
Experience of Managing Countertransference Through Self-Guided Imagery in Meditation Among Healthcare Professionals
Authors: Aasan Olaug Julie , Brataas Hildfrid Vikkelsmo , Nordtug Bente 
Published: February 2022

IntroductionAs a part of the therapeutic relationship, a significant, well-established predictor of outcomes in psychiatric healthcare, healthcare professionals' emotional reactions to patients may affect treatment outcomes.AimThe aim of our study was to explore and describe healthcare professionals' experiences with managing countertransference using skills from a training program on self-guided imagery in meditation (SIM).MethodFollowing an exploratory descriptive design, we conducted qualitative interviews with 10 healthcare professionals who care for patients with mental illness and subjected the collected data to thematic content analysis.ResultsParticipants reported that SIM had helped them to manage countertransference and had prompted changes that we categorized into three themes: managing personal vulnerability, setting clearer boundaries, and practicing self-care.ConclusionThe results suggest that by cultivating wellbeing and dealing with unresolved inner conflicts, SIM can help healthcare professionals to manage countertransference.