bluuebunny/crossref_metadata_2025_split huggingface dataset:
Process Optimization for Hydrothermal-Assisted Jet Fusion Additive Manufacturing of Ceramics
Authors: Fei Fan , Kirby Levi , Song Xuan 
Published: September 2022

Abstract
Hydrothermal-assisted jet fusion (HJF) process is a new additive manufacturing (AM) method for ceramics, which is capable of fabricating ceramic 3D structures without the need for organic binders. The HJF process selectively deposits a water-based solution into a ceramic powder bed in a layer-by-layer manner and fuses particles together through a hydrothermal mechanism. Since no organic binder is used in the HJF process, such a binder-free AM method can produce ceramic parts with less energy consumed for binder removal and has the potential to reach the material’s theoretical properties such as full density and exceptional mechanical strength. Nevertheless, the fabricated parts by the HJF process still suffers from issues, such as over fusion base-layer damage, pattern shifting, etc. In this paper, the effects of process parameters (e.g., stroke, droplet size, press number, final press, etc.) on the fabrication quality (e.g., diffusion behavior of deposited inks and shape fidelity of the fabricated parts, etc.) of the HJF process are studied. Optimum process settings are identified to alleviate those quality issues, and 3D structures with high shape fidelity were successfully fabricated to highlight the capability of the HJF process in achieving ceramic 3D structures with high accuracy and high performance.
Shape Memory Properties of 4D Printed Parts Under Cyclic Loading: Effects of Infill Characteristics and Stimulus Conditions
Authors: Han Muyue , Zhao Jing , Li Lin , Tan Miao 
Published: September 2022

Abstract
4D printing has spurred growing interests since its recent emergence, as it enables the fabrication of dynamic structures with reconfigurability over time when exposed to external stimuli, which is not feasible using 3D printing. The current literature on 4D printing is mainly focused on developing new materials and investigating the time-evolving properties of the printed parts, whereas the influences of process parameters on stimuli-response behaviors of 4D printed parts are not adequately explored, especially under cyclic loadings. In this study, experimental analyses are conducted to investigate the effects of infill strategies and stimulus conditions on the shape memory properties of 4D printed thermo-responsive parts. Specifically, cyclic thermo-mechanical tests are performed under different operating temperatures to investigate the shape programmability and recovery characteristic of specimens printed with various infill patterns. The results indicate that specimens printed with the rectilinear pattern exhibit better shape programmability under cyclic thermo-mechanical loadings than polygonal patterns. In addition, the decrease in shape fixity ratios over multiple cycles is also observed for all considered infill patterns. The comparative studies suggest that the increase in operating temperature within the vicinity of the material’s glass transition temperature can improve the cyclic shape memory property.
Understanding maternity waiting home uptake and scale-up within low-income and middle-income countries: a programme theory from a realist review and synthesis
Authors: Uwamahoro Nadege Sandrine , McRae Daphne , Zibrowski Elaine , Victor-Uadiale Ify , Gilmore Brynne , Bergen Nicole , Muhajarine Nazeem 
Published: September 2022

IntroductionMaternity waiting homes (MWHs) link pregnant women to skilled birth attendance at health facilities. Research suggests that some MWH-facility birth interventions are more success at meeting the needs and expectations of their intended users than others. We aimed to develop theory regarding what resources work to support uptake and scale-up of MHW-facility birth interventions, how, for whom, in what contexts and why.MethodsA four-step realist review was conducted which included development of an initial programme theory; searches for evidence; selection, appraisal and extraction of data; and analysis and data synthesis.ResultsA programme theory was developed from 106 secondary sources and 12 primary interviews with MWH implementers. The theory demonstrated that uptake and scale-up of the MWH-facility birth intervention depends on complex interactions between three adopter groups: health system stakeholders, community gatekeepers and pregnant women and their families. It describes relationships between 19 contexts, 11 mechanisms and 31 outcomes accross nine context-mechanism-outcome configurations (CMOCs) which were grouped into 3 themes: (1) Engaging stakeholders to develop, integrate, and sustain MWH-facility birth interventions, (2) Promoting and enabling MWH-facility birth utilisation and (3) Creating positive and memorable MWH-facility birth user experiences. Belief, trust, empowerment, health literacy and perceptions of safety, comfort and dignity were mechanisms that supported diffusion and adoption of the intervention within communities and health systems. Examples of resources provided by implementers to trigger mechanisms associated with each CMOC were identified.ConclusionsImplementers of MWHs cannot merely assume that communities will collectively value an MWH-facility birth experience over delivery at home. We posit that MWH-facility birth interventions become vulnerable to under-utilisation when implementers fail to: (1) remove barriers that hinder women’s access to MWH and (2) ensure that conditions and interactions experienced within the MWH and its affiliated health facility support women to feel treated with compassion, dignity and respect.PROSPERO registration numberCRD42020173595.
Bargaining and gendered authority: a framework to understand household decision-making about childhood vaccines in the Philippines
Authors: Wachinger Jonas , Reñosa Mark Donald C , Endoma Vivienne , Aligato Mila F , Landicho-Guevarra Jhoys , Landicho Jeniffer , Bravo Thea Andrea , McMahon Shannon A 
Published: September 2022

IntroductionTargeted vaccination promotion efforts aimed at building vaccine confidence require an in-depth understanding of how and by whom decisions about vaccinating children are made. While several studies have highlighted how parents interact with other stakeholders when discussing childhood vaccination, less is known about the way in which vaccination uptake is negotiated within households.MethodsWe conducted 44 in-depth interviews with caregivers of children under five in the Philippines who had delayed or refused vaccination. Interviews were conducted between August 2020 and March 2021 and were audio-recorded, transcribed verbatim and translated into English. Notions of intra-household vaccination bargaining emerged early during systematic debriefings and were probed more pointedly throughout data collection.ResultsParents as well as paternal and maternal families proved to be dominant stakeholders in intra-household bargaining for childhood vaccination. Although bargaining among these stakeholders was based on engrained, gender-based power imbalances, disadvantaged stakeholders could draw on a range of interrelated sources of bargaining power to nevertheless shape decision-making. Sources of bargaining power included, in descending order of their relevance for vaccination, (1) physical presence at the household (at the time of vaccination decision-making), (2) interest in the topic of vaccination and conviction of one’s own position, (3) previous vaccination and caregiving experience, and (4) access to household resources (including finances). The degree to which each household member could draw on these sources of bargaining power varied considerably over time and across households.ConclusionOur findings highlight how bargaining due to intra-household disagreement coins decisions regarding childhood vaccination. Considering the risks for public health associated with vaccine hesitancy globally, we advocate for acknowledging intra-household dynamics in research and practice, such as by purposefully targeting household members with decision-making capacity in vaccination promotion efforts, aligning promotion efforts with available bargaining capacity or further empowering those convinced of vaccination.
Identification of novel HLA-A*11:01-restricted HPV16 E6/E7 epitopes and T-cell receptors for HPV-related cancer immunotherapy
Authors: Xiong Chengjie , Huang Lihong , Kou Hedan , Wang Chenwei , Zeng Xiaomin , Sun Hanli , Liu Shangyuan , Wu Bin , Li Jingyao , Wang Xiaoling , Wang Zibing , Chen Lin 
Published: September 2022

BackgroundE6 and E7 oncoproteins are considered ideal antigens of T cell therapy for human papillomavirus (HPV)-related cancers. However, little is known about the epitopes of E6 and E7 presented by HLA-A*11:01, one of the most prevalent HLA types globally, especially in Asia.MethodsWe combinedin silicoand experimental approaches to identify endogenously processed HLA-A*11:01-restricted epitopes of HPV16 E6 and E7. The identified epitopes were then used to screen available T cell receptors (TCRs) from healthy donors throughin vitrostimulation of peripheral blood mononuclear cells (PBMCs).ResultsE693-101(TTLEQQYNK, TTL) and E789-97(IVCPICSQK, IVC), two novel HLA-A*11:01-restricted T cell epitopes of HPV16, were identified to be endogenously presented on tumor cells. TTL- and IVC-specific TCRs were isolated from 11 healthy donors throughin vitrostimulation of PBMC. The key TTL and IVC residues involved in TCR-pMHC interactions were mapped, and the consensus sequence was “xxLEQxYNK” and “xVxPIxxxK.” The TTL- and IVC-specific TCRs with high functional avidity were used to generate TCR-engineered T cells, specifically recognizing and killing corresponding tumor cell lines in vitro and in vivo. In addition, TTL and IVC-specific TCR-T cells also recognized and killed HPV16+patient-derived organoids.ConclusionsThe HLA-A*11:01-restricted HPV16 E6/E7 epitopes and TCRs identified in this study may provide a new strategy for HPV-related cancer immunotherapy in HLA-A*11:01+patients.
Admixture mapping of severe asthma exacerbations in Hispanic/Latino children and youth
Authors: Herrera-Luis Esther , Mak Angel C Y , Perez-Garcia Javier , Martin-Gonzalez Elena , Eng Celeste , Beckman Kenneth B , Huntsman Scott , Hu Donglei , González-Pérez Ruperto , Hernández-Pérez José M , Mederos-Luis Elena , Sio Yang Yie , Poza-Guedes Paloma , Sardón Olaia , Corcuera Paula , Sánchez-Machín Inmaculada , Korta-Murua Javier , Martínez-Rivera Carlos , Mullol Joaquim , Muñoz Xavier , Valero Antonio , Sastre Joaquin , Garcia-Aymerich Judith , Llop Sabrina , Torrent Maties , Casas Maribel , Rodríguez-Santana José R , Villar Jesús , del Pozo Victoria , Lorenzo-Diaz Fabian , Williams L Keoki , Melén Erik , Chew Fook Tim , Borrell Luisa N , Burchard Esteban G , Pino-Yanes Maria 
Published: September 2022

BackgroundIn the USA, genetically admixed populations have the highest asthma prevalence and severe asthma exacerbations rates. This could be explained not only by environmental factors but also by genetic variants that exert ethnic-specific effects. However, no admixture mapping has been performed for severe asthma exacerbations.ObjectiveWe sought to identify genetic variants associated with severe asthma exacerbations in Hispanic/Latino subgroups by means of admixture mapping analyses and fine mapping, and to assess their transferability to other populations and potential functional roles.MethodsWe performed an admixture mapping in 1124 Puerto Rican and 625 Mexican American children with asthma. Fine-mapping of the significant peaks was performed via allelic testing of common and rare variants. We performed replication across Hispanic/Latino subgroups, and the transferability to non-Hispanic/Latino populations was assessed in 1001 African Americans, 1250 Singaporeans and 941 Europeans with asthma. The effects of the variants on gene expression and DNA methylation from whole blood were also evaluated in participants with asthma and in silico with data obtained through public databases.ResultsGenomewide significant associations of Indigenous American ancestry with severe asthma exacerbations were found at 5q32 in Mexican Americans as well as at 13q13-q13.2 and 3p13 in Puerto Ricans. The single nucleotide polymorphism (SNP) rs1144986 (C5orf46) showed consistent effects for severe asthma exacerbations across Hispanic/Latino subgroups, but it was not validated in non-Hispanics/Latinos. This SNP was associated withDPYSL3DNA methylation andSCGB3A2gene expression levels.ConclusionsAdmixture mapping study of asthma exacerbations revealed a novel locus that exhibited Hispanic/Latino-specific effects and regulatedDPYSL3andSCGB3A2.
Was the San Quintín kangaroo rat really rediscovered?
Authors: Andrade-Sánchez Jorge , Arteaga Maria Clara , Mellink Eric 
Published: September 2022

The San Quintín kangaroo rat ( Dipodomys gravipes Huey, 1925) is one of the three kangaroo rats in northwestern Baja California and the largest of them in most body dimensions. After a dramatic population decline in the 1980s, it was declared as potentially extinct in the wild by Mexican law. In 2017, the species was claimed to be rediscovered, but critical data supporting the species recognition were not provided. The question remained: Was the San Quintín kangaroo rat really rediscovered? We analyzed individuals identified by us as D. gravipes to validate our identification. We compared cranial morphometric and mitochondrial data of on-purpose collected specimens with those of historic specimens and with those of sympatric kangaroo rats in Baja California, particularly the Dulzura kangaroo rat ( Dipodomys simulans (Merriam, 1904)). Cranial morphometry and body dimensions of current specimens are indistinguishable from those of historic D. gravipes, while being different from D. simulans in most dimensions. External measurements such as cranial traits adequately distinguish both species. The mitochondrial analysis revealed strong support for the species grouping of sequences of our specimens and DNA sequences of D. gravipes from the GenBank repository. This study comprises a morphometric and molecular confirmation of the presence of the species after >25 years of failures to find it.
The Persistent Homology of Cyclic Graphs
Authors: Adams Henry , Coldren Sophia , Willmot Sean 
Published: September 2022

We give an [Formula: see text] algorithm for computing the [Formula: see text]-dimensional persistent homology of a filtration of clique complexes of cyclic graphs on [Formula: see text] vertices. This is nearly quadratic in the number of vertices [Formula: see text], and therefore a large improvement upon the traditional persistent homology algorithm, which is cubic in the number of simplices of dimension at most [Formula: see text], and hence of running time [Formula: see text] in the number of vertices [Formula: see text]. Our algorithm applies, for example, to Vietoris–Rips complexes of points sampled from a curve in [Formula: see text] when the scale is bounded depending on the geometry of the curve, but still large enough so that the Vietoris–Rips complex may have non-trivial homology in arbitrarily high dimensions [Formula: see text]. In the case of the plane [Formula: see text], we prove that our algorithm applies for all scale parameters if the [Formula: see text] vertices are sampled from a convex closed differentiable curve whose convex hull contains its evolute. We ask if there are other geometric settings in which computing persistent homology is (say) quadratic or cubic in the number of vertices, instead of in the number of simplices.
Patients with Ankylosing Spondylitis Can Maintain Clinical and Functional Improvement after Switching from Infliximab Reference Product to Infliximab Biosimilar (REMSIMA): 12 Months Comparative Open-Label Study
Authors: Mathkhor Abdulsatar J. , Altaqi Ali , Abdullah Abdulnasser , Khudhairy Amer 
Published: September 2022

Objective: Efficacy, tolerance, and safety of infliximab biosimilar are the same as infliximab reference product (RP) in the management of ankylosing spondylitis (AS) patients previously were on infliximab RP. We aimed to evaluate the biosimilar CT-P13 (Remsima) in terms of efficacy, tolerance, and safety to its RP. Materials and methods: Seventy-eight consecutive randomly selected patients were recruited for the study. All patients were naïve to any other biologics before receiving infliximab RP, and all were in clinical remission. The sample of patients was divided into two subgroups: 40 patients were continued on infliximab RP and 38 patients were switched to infliximab biosimilar. All patients underwent clinical evaluation and investigation. Both groups followed up for further 12 months. The disease activity was calculated utilizing Ankylosing Spondylitis Disease Activity Score (ASDAS), using the C-reactive protein (CRP), and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Remission considered when BASDAI < 4 and ASDAS < 1.3. Functional scores for all patients were assessed using the Bath Ankylosing Spondylitis Functional Index (BASFI). Results: Sustained clinical remission was observed after 12 months of treatment in the infliximab RP continued and switched groups. At the end of the study, erythrocyte sedimentation rate (ESR), CRP, visual analog scale (VAS), ASDAS, BASDAI, and BASFI were 15.04 ± 2.37, 2.10 ± 0.88, 3.10 ± 0.78, 1.52 ± 0.40, 2.80 ± 0.37, and 3.05 ± 0.24 in the infliximab RP continued group, respectively, and were 15.15 ± 1.45, 2.29 ± 0.89, 3.21 ± 0.69, 1.59 ± 0.57, 2.76 ± 0.45, and 2.89 ± 0.92 for the switching group, respectively; the difference was statistically not significant ([Formula: see text] values > 0.05). No significant adverse events were noted in the switching group compared to the continuous group groups. Conclusion: We found infliximab biosimilar CT-P13 (Remsima) was not inferior to infliximab RP and can maintain patients with ankylosing spondylitis in clinical remission.
Sverdrup Basin Composite Tectono-Sedimentary Element, Canadian Arctic Islands
Authors: Embry Ashton , Beauchamp Benoit , Dewing Keith , Harrison Christopher 
Published: September 2022

Abstract

The Sverdrup Basin Composite Tectono-Sedimentary Element (CTSE) covers 210 000 km
2
in the Canadian Arctic Archipelago. The CTSE was initiated in the Early Carboniferous by rifting of highly deformed Early Paleozoic strata and contains a maximum of 15 km of Carboniferous–Eocene strata. Eight phases of basin development have been recognized, with each being characterized by a specific combination of tectonic and depositional regimes. The phases are separated by intervals of uplift and tectonic reorganization, and each resultant first-order sequence is regarded as a separate TSE. Carbonate sedimentation was dominant in the Late Carboniferous and Early Permian, with clastic sedimentation becoming more common in the Middle Permian. Source areas lay to the east, south and north. In the Triassic, clastic sedimentation rates increased; and by the end of the Triassic, the central basin was filled. A shallow seaway was present throughout the Jurassic. In the Early Cretaceous, subsidence rates and clastic supply increased significantly, and basic volcanism occurred over most of the CTSE. Subsidence rate, sediment supply and volcanism decreased in the Late Cretaceous. The basin was progressively deformed in the Paleogene (Eurekan Orogeny), with local foreland deposits reaching 3 km. Seventeen oil and gas fields have been discovered on salt-cored, Eurekan anticlines. A combination of stratigraphic and structural traps, involving Triassic–Jurassic strata, has the greatest potential for future hydrocarbon discoveries.
Algebraic Properties of

ω
,
θ

-Complex Fuzzy Subgroups
Authors: Al-harshni Ahad Abdullah , Alghazzawi Dilshad 
Published: September 2022

This paper defined the notion of

ω
,
θ

-complex fuzzy sets,

ω
,
θ

-complex fuzzy subgroupoid, and

ω
,
θ

-complex fuzzy subgroups and described important examples under

ω
,
θ

-complex fuzzy sets. Additionally, we discussed the conjugacy class of group with respect to

ω
,
θ

-complex fuzzy normal subgroups. We define

ω
,
θ

-complex fuzzy cosets and elaborate the certain operation of this analog to group theoretic operation. We prove that factor group with regard to

ω
,
θ

-complex fuzzy normal subgroup forms a group and establishes an ordinary homomorphism from group to its factor group with regard to

ω
,
θ

-complex fuzzy normal subgroup. Moreover, we create the

ω
,
θ

-complex fuzzy subgroup of factor group.
Madden–Julian Oscillation Impacts on Australian Temperatures and Extremes
Authors: Marshall Andrew G. , Wheeler Matthew C. , Cowan Tim 
Published: September 2022

Abstract
We assess seasonally varying impacts of the Madden–Julian oscillation (MJO) on Australian maximum and minimum temperature anomalies and extremes, and their modulation by El Niño–Southern Oscillation (ENSO), for the period June 1974–May 2022. Our composite-based approach uses observed temperatures from the Australian Gridded Climate Data, and 850-hPa wind data from the NCEP–NCAR reanalysis, to show how relationships to temperature and circulation evolve over the eight-phase life cycle of the MJO, which we derive from the real-time multivariate MJO index. The MJO has significant impacts on Australian temperatures and winds in all parts of the country at various times throughout the year, and to varying degrees. Two of the most pronounced impacts are 1) daytime warming across southeastern Australia in MJO phase 3 during spring associated with a strong anomalous anticyclone and 2) nighttime cooling over Queensland in MJO phase 7 during winter associated with anomalous advection of cool dry continental air. La Niña acts to significantly lessen both of these impacts, while El Niño enhances both the phase 3 warming over southern Australia in spring and the phase 7 overnight cooling over southern Queensland in winter. We show how the MJO can combine with El Niño and La Niña to have strong compounding influences, thus highlighting the importance of understanding interactions between multiple modes of climate variability and how they relate to Australian temperatures and extremes.
Impact of Assimilating Radar Data with 3D Thermodynamic Fields in an Ensemble Kalman Filter: Proof of Concept and Feasibility
Authors: Ke Chieh-Ying , Chung Kao-Shen , Liou Yu-Chieng , Tsai Chih-Chien 
Published: September 2022

Abstract
This study examined the impact of assimilating 3D temperature and water vapor information in addition to radar observations in a multiscale weather system. A frontal system with extremely heavy rainfall over northern Taiwan was selected. Using the WRF–LETKF Radar Assimilation System, we performed three sets of observing system simulation experiments to assimilate radar observations with or without thermodynamic variables obtained using different methods. First, assimilating the radar data for 2 h showed better structure and short-term forecast than 1 h. Second, we assimilated radar data and thermodynamic variables from a perfect model simulation. The results of the analysis revealed that when a precipitation position error occurred in the background field, assimilating thermodynamic information with the radar data could correct the dynamic structure and shorten the spinup assimilation period, resulting in substantial improvements to the quantitative precipitation forecast. Third, we applied a thermodynamics retrieval algorithm for a feasibility study. With a warm and wet bias of the retrieved fields, assimilating the temperature data had significant impact on the midlevel of stratiform areas and the forecast of the heavy rainfall was consequently improved. Assimilating the water vapor information helped reconstruct the range and intensity of the cold pool, but the improvement of rainfall forecast was limited. The optimal results of analysis and short-term forecast were achieved when both retrieved temperature and water vapor fields were assimilated. In conclusion, assimilating thermodynamic variables in the precipitation system is feasible for shortening the spinup period of data assimilation and improving the analysis and short-term forecast.