bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acinar Cell Carcinoma of Gastric Ectopic Pancreas Origin: A Case Report and Literature Review
Authors: Chen Ying , Zhou Ning , Guo Deyu , He Xin , Tang Hao , Wang Lina , Xu Yujuan , Xu Tingting 
Published: August 2022

Abstract
Background
Primary pancreatic-type acinar cell carcinoma of the stomach is extremely rare, often misdiagnosed, and of unclear origin.
Case presentation:
We report the case of a primary pure pancreatic-type acinar cell carcinoma of the stomach in a 58-year-old woman. This is the first reported case to exhibit residual ectopic pancreatic tissue adjacent to the tumor serving as evidence for the origin of the carcinoma. Furthermore, we summarized the clinicopathological features of pancreatic-type acinar cell carcinoma of the stomach in order to further understand this solid tumor.
Conclusions
Primary pancreatic-type acinar cell carcinoma of the stomach is rare. Data on tumors of this histological type are still relatively scarce, and more in-depth research is needed to elucidate their molecular biological characteristics and prognosis.
Success rate and predictive factors of return to work after the implementation of a return-to-work trajectory: A retrospective cohort study
Authors: Boets Isabelle , Luyten Steven , Vandenbroeck Sofie , Godderis Lode 
Published: August 2022

Abstract

Purpose:To reduce long-term absenteeism, several countries take legislative initiatives. In this study, we evaluate the impact of a legally defined return-to-work (RTW) trajectory on the RTW of sick-listed employees.Methods:We conducted a retrospective registered-based cohort study on Belgian employees (N = 1416) who followed a RTW-trajectory in 2017. We linked workers’ data from a Service for Prevention and Protection at Work with data from the Crossroads Bank for Social Security. We analysed how many employees RTW with the same employer, with another employer or not at all. By multinomial logistic regression, we analysed which characteristics are predictive for RTW.Results:One year after their trajectory, 69.2% of employees did not RTW, 10.7% did RTW with the same employer, 20.1% did RTW with a new employer. Duration of sickness absence (SA) was an important predictor for both RTW with the same as with another employer. When duration of SA exceeded six months, odds of RTW were lower than when the duration of SA was < six months. Marital status, organization-size, and decision of occupational physician had significant impact on RTW with the same employer, while age and who initiated the trajectory were key factors for RTW with another employer.Conclusions:30.8% of employees succeeded to RTW after their trajectory. Results show that a one-size-fits-all-approach is not recommended. A stepped approach with an early, informal start of the RTW-process should be implemented. When employees or employers fail to initiate RTW on their own, a legally defined RTW-trajectory could be useful.
Global Research Trends at the Intersection of Acupuncture and Headache Disorders: A Bibliometric Analysis
Authors: Ng Jeremy Y. , Fakuade Ayomide 
Published: August 2022

Abstract
Introduction: Headache disorders are among one of the most common nervous system disorders affecting approximately 50% of adults worldwide. Acupuncture is a therapy originating from traditional Chinese medicine; some research has suggested that its use may relieve headache disorders. The objective of the present bibliometric analysis is to capture the characteristics of peer-reviewed publications at the intersection of headache and acupuncture research.Methods: Searches were run on July 08, 2021, and results were exported on the same day to prevent discrepancies between daily database updates. Trends associated with this subset of publications were identified and presented. Bibliometric networks were constructed and visualized using the software tool VOSviewer.Results: A total of 592 publications, published by 1482 authors were published in 231 journals from 1965 to 2021. An upward trend in the annual number of publications can be observed starting in the mid-1970s. The journal that published the largest number of publications was Deutsche Zeitschrift Fur Akupunktur. The most productive countries included China and Germany.Conclusions: The present study provides the characteristics of the literature at the intersection of headache disorders and acupuncture that allows understanding of the past, present, and future of research in this area.
Chromatin accessibility shapes tumor architecture and microenvironment in clear cell renal cell carcinoma
Authors: Wu Yige , Terekhanova Nadezhda , Caravan Wagma , Karpova Alla , Cao Song , Chen Siqi , Zhu Houxiang , Lal Preet , Serasanambati Mamatha , Yang Xiaolu , Liu Ruiyang , Wyczalkowski Matthew , Yao Lijun , Zhou Daniel Cui , Jayasinghe Reyka , Zhao Yanyan , Mendez Daniel , Wendl Michael , Clark David , Newton Chelsea , Ruan Yijun , Kinsinger Chris , Jewell Scott , Chan Daniel , Zhang Hui , Chaudhuri Aadel , Humphreys Benjamin , Chheda Milan , Mesri Mehdi , Rodriguez Henry , Hsieh James , Ding Li , Chen Feng 
Published: August 2022

Abstract
The molecular landscape of clear cell renal cell carcinoma (ccRCC) has been annotated by a number of large-scale sequencing studies, complemented by recent proteomics efforts. However, these bulk analyses are limited by the diverse cell populations that compose these tumors. Here, we obtained single-nucleus RNA-seq (snRNA-seq) and ATAC-seq (snATAC-seq) data from 31 and 13 samples from ccRCC patients, respectively, with matching bulk proteogenomics data collected through the National Cancer Institute Clinical Proteomic Tumor Analysis Consortium (CPTAC). We found an average of 4 distinct populations of tumor cells with substantial transcriptional differences per sample and 7.5% of clusters with epithelial-to-mesenchymal transition (EMT) features, characterized by high expression of known mesenchymal genes, and Wnt pathway genes and enriched TWIST and AP-1 complex (JUN, ATF2) motifs. We also observed substantial tumor genomic heterogeneity, including cluster-specific chromosome 3p loss and 5q gain from the same patient, suggesting both events can drive ccRCC, possibly through tumor cell interactions. We identified growth factor-receptor interactions between IGF1 (macrophages) and IGF1R (tumor cells), HBEGF (macrophages) and EGFR (tumor cells), in addition to the well-known interaction between VEGFA (tumor cells) and FLT1 (endothelial cells). Using paired snATAC-seq and snRNA-seq, we found ccRCC cells were most similar to proximal tubule cells among the six nephron epithelial cell types identified. We also identified previously unknown tumor cell-specific transcription factor (TF) motifs, including those for NFIC, RORC, and RBPJ, regulating genes involved in glycolysis (PFKP), and others potentially in collaboration with HIF1A. Finally, tumors harboring genetic alterations in chromatin remodeling genes (BAP1/PBRM1) showed distinct genome-wide and fine-scale chromatin accessibility profiles compared to other tumors, with enriched motifs for the nuclear factor-κB TFs. In summary, we find that various differential transcriptional network activities are likely key drivers in ccRCC pathogenesis and progression.
Health, wealth, and medical expenditures among the elderly in rural Tanzania: Experiences from Nzega and Igunga districts
Authors: Tungu Malale M. , Mujinja Phares G. , Amani Paul J. , Mwangu Mughwira A. , Kiwara Angwara D. , Lindholm Lars 
Published: August 2022

Abstract
Background
The per capita health expenditure (HE) and share of gross domestic product (GDP) spending on elderly healthcare are expected to increase. In many developing countries like Tanzania, there is an increasing gap between health needs and the available resources for elderly healthcare, which leaves the elderly with poor health conditions, especially chronic diseases. These conditions lead to catastrophic HEs for the elderly.
Objective
This study aimed to analyse the association among health, wealth, and medical expenditure in rural residents aged 60 years and above in Tanzania.
Methods
Data were collected through a cross-sectional household survey to rural residents aged 60 years and above living in Nzega and Igunga districts. Standardised World Health Organization (WHO) Study on Global Ageing and Adult Health (SAGE) and European Quality of Life Five Dimension (EQ-5D) questionnaires were used. The quality of life (QoL) was estimated using EQ-5D weights. The wealth index was generated from principal component analysis (PCA). Two linear regression analyses (outpatient/inpatient) were performed to analyse the association among health, wealth, medical expenditure, and socio-demographic variables.
Results
This study found a negative and statistically significant association between QoL and HE, whereby HE increases with the decrease of QoL. We could not find any significant relationship between HE and social gradients. In addition, age influences HE such that as age increases, the HE for both outpatient and inpatient care also increases.
Conclusion
The health system in these districts allocate resources mainly according to needs, and social position is not important. We thus conclude that the system is fair. Health, not wealth, determines the use of medical expenditures.
Conformal bootstrap bounds for the $U(1)$ Dirac spin liquid and $N=7$ Stiefel liquid
Authors: He Yin-Chen , Rong Junchen , Su Ning 
Published: August 2022

We apply the conformal bootstrap technique to study the
U(1)U(1)
Dirac spin liquid (i.e. N_f=4Nf=4
QED_33)
and the newly proposed N=7N=7
Stiefel liquid (i.e. a conjectured 3d non-Lagrangian CFT without
supersymmetry). For the N_f=4Nf=4
QED_33,
we focus on the monopole operator and (SU(4)SU(4)
adjoint) fermion bilinear operator. We bootstrap their single
correlators as well as the mixed correlators between them. We first
discuss the bootstrap kinks from single correlators. Some exponents of
these bootstrap kinks are close to the expected values of
QED_33,
but we provide clear evidence that they should not be identified as the
QED_33.
By requiring the critical phase to be stable on the triangular and the
kagome lattice, we obtain rigorous numerical bounds for the
U(1)U(1)
Dirac spin liquid and the Stiefel liquid. For the triangular and kagome
Dirac spin liquid, the rigorous lower bounds of the monopole operator’s
scaling dimension are 1.0461.046
and 1.1051.105,
respectively. These bounds are consistent with the latest Monte Carlo
results.
Enhanced removal of dissolved S2− from a river by the pump-and-treat ex-situ process with enriched consortium
Authors: Song Chen , Shi Yajun , Gao Hongjie , Ren Hongwei , Liu Xiaoling 
Published: August 2022

Abstract
S2− is one of the common pollutants in heavily polluted rivers. A pump-and-treat ex-situ process with enriched consortium (PEPEC) was used to remove S2− in this study. The kinetic model of S2− removal was developed, and the inflow ratio of the PEPEC was analyzed according to the results of the kinetic models. The results showed that the S2− removal ratio could reach 97.5% ± 0.5%, when the inflow ratio was controlled at 2% for the PEPEC operation. Meanwhile, the removal efficiency and operation performance were assessed for both the simulating ex-situ and in-situ bench-scale tests. Compared with the in-situ processes, the PEPEC showed a stable operation performance during 120 h of bio-treatment, and the concentrations of S2−, COD, NH3-N and TP in the effluent reached approximately 0.5, 20, 0.5 and 0.5 mg/L, respectively. The time consumption (8 h for one batch) and consortium dosage (3 g for the whole operation) in the PEPEC were significantly less than those in the in-situ processes. The PEPEC presented some potential advantages for the bio-treatment of a heavily polluted river.
PENINGKATAN MOTIVASI DAN HASIL BELAJAR SISWA TENTANG PERKEMBANGAN SISTEM ADMINISTRASI WILAYAH INDONESIA MELALUI PENGGUNAAN MODEL GROUP FINDING PADA SISWA KELAS VI SD N III KRISAK KECAMATAN SELOGIRI KABUPATEN WONOGIRI SEMESTER I TAHUN PELAJARAN 2015 /2016
Authors: Sudarni Sri 
Published: August 2022

ABSTRAK Tujuan penelitian tindakan kelas ini adalah untuk meningkatkan motivsi dan hasil belajar tentang materi perkembangan sistem administrasi wilayah Indonesia melalui penggunaan model Group Finding siswa kelas VI SD N III Krisak Kecamatan Selogiri Kabupaten Wonogiri tahun pelajaran 2015/2016. Penelitian ini merupakan jenis penelitian tindakan kelas, dengan subyek penelitiannya adalah siswa kelas VI SD N III Krisak Kecamatan Selogiri Kabupaten Wonogiri tahun pelajaran 2015/2016. Hasil penelitian menunjukkan bahwa model pembelajaran Group Finding yang dilaksanakan oleh guru menunjukkan dapat meningkatkan motivasi dan hasil belajar tentang tentang materi perkembangan sistem administrasi wilayah Indonesia pada siswa kelas VI SD N III Krisak Kecamatan Selogiri Kabupaten Wonogiri tahun pelajaran 2015/2016. Hal ini terbukti dari hasil penelitian yang dilakukan dalam 2 siklus, yaitu prosentase ketuntasan siswa mengalami peningkatan dari siklus I ke siklus II yaitu siklus I yang semula hanya terdapat 12 siswa yang tuntas atau 57%, lalu pada siklus II meningkat menjadi siswa 18 yang tuntas atau 87% dari jumlah keseluruhan 21 siswa, sehingga prosentase ketuntasan meningkat sebesar 30%. Kata Kunci : Model Group Finding, Motivasi dan Hasil Belajar
NILAI-NILAI PENDIDIKAN DALAM LIRIK NYANYIAN MAMBUE ANAK SUKU BATAK ANGKOLA DI KABUPATEN TAPANULI SELATAN PROVINSI SUMATERA UTARA
Authors: Pulungan Husniah Ramadhani , Daulay Ismail Rahmad , Hasibuan Ahmad Yamin 
Published: August 2022

AbstrakPenelitian yang telah dikemukakan, penelitian ini bertujuan mendeskripsikan nilai-nilai pendidikan dalam syair nyanyian mambue anak pada suku Batak Angkola di Kabupaten Tapanuli Selatan. Tujuan penelitian adalah (1) Mendeskripsikan jenis-jenis nyanyian mambue anak pada suku BatakAngkola di Kabupaten Tapanuli Selatan Provinsi Sumatera Utara dan (2) Mendeskripsikan nilai-nilai pendidikan dalam lirik nyanyian mambue anak pada suku Batak Angkola di Kabupaten Tapanuli Selatan Provinsi Sumatera Utara. Data yang terkumpul melalui teknik-teknik yang telah dikemukakan di atas kemudian diolah atau diproses sebagai berikut (1) Mengumpulkan data tentang Kata Majemuk Bahasa Batak Angkola yang diperoleh dari masyarakat. (2) Data yang diperoleh berupa ujaran-ujaran informan, ditranskripsikan ke dalam bentuk tulisan. (3) Mengklasifikasikan data yang diperoleh berdasarkan permasalahan yang diteliti. (3) Data yang telah diperoleh diterjemahkan ke dalam Bahasa Indonesia dan menyusun laporan hasil analisis data. Dan (3) Menarik simpulan. Berdasarkan temuan penelitian mengenai nilai-nilai edukatif dalam lirik Nyanyian Mambue anak pada acara pernikahan Suku Batak Angkola Kabupaten Tapanuli Selatan Provinsi Sumatera Utara dapat disimpulkan (1) Nilai-nilai edukatif religious, (2) Nilai-nilai edukatif ketangguhan, (3) Nilai-nilai edukatif kepedulian, dan (4) Nilai-nilai Kejujuran. Kata Kunci: Nilai-Nilai Pendidikan, Kearifan Lokal, Nyanyian Mambue Anak, dan Suku Batak Angkola.
MEMPERTAHANKAN IDEALISME MATA PELAJARAN BAHASA INGGRIS DI SEKOLAH DASAR DI PONOROGO
Authors: Indriastuti Niken Reti 
Published: August 2022

Banyak sekolah dasar di kabupaten Ponorogo yang masih mempertahankan keberadaan bahasa Inggris sebagai mata pelajaran walaupun bahasa Inggris tidak ada dalam kurikulum nasional sekolah dasar. Penelitian ini bertujuan untuk mengeathui idealisme apa yang dimiliki sekolah-sekolah tersebut sehingga masih mempertahankan bahasa Inggris sebagai mata pelajaran dan sejauh mana usaha mereka dalam mempertahankan idealisme tersebut. Seting penelitian ini adalah SD Muhammadiyah Ponorogo dan SD Muhammadiyah Terpadu Ponorogo yang merupakan sekolah swasta cukup favorit di Ponorogo, subyek penelitian adalah mata pelajaran bahasa Inggris. Instrument yang digunakan untuk mengumpulkan data adalah interview dan observasi. Sedangkan teknik analisa data memakai model Miles dan Huberman. Berdasarkan hasil pengolahan data maka diperoleh gambaran bahwa kedua sekolah tersebut memiliki alasan sebagai berikut: (1) mempersiapkan siswa untuk menghadapai pelajaran Bahasa Inggris di SMP dan (2) membekali siswa dalam menghadapi globalisasi dan kemajuan teknologi informasi (ICT). Namun upaya untuk mencapai idealisme tersebut bisa dikatakan kurang idealis yang disebabkan berbagai factor baik berasal dari pihak otoritas sekolah: kepala sekolah dan guru bahasa Inggris maupun dari siswa dan orang tua.
Influence of Organic Solvents and β-cyclodextrins on Capillary Zone Electrophoresis Separation of Five Biogenic Amines and Two B Vitamins
Authors: Matuskova M. , Cizmarova I. , Chalova P. , Stefanik O. , Horniakova A. , Mikus P. , Piestansky J. 
Published: August 2022

Abstract
The effects of organic modifiers—alcohols (methanol, isopropanol), acetonitrile, and tetrahydrofuran—and β-cyclodextrins in capillary zone electrophoresis were investigated using a test mixture containing five biogenic amines important from the human health point of view—serotonin, dopamine, adrenaline, noradrenaline, and tyramine—and two B vitamins—thiamine and pyridoxine. The simultaneous addition of tetrahydrofuran and isopropanol was found to improve the resolution of determined analytes and enable effective separation of analytes with very similar electromigration characteristics migrating as one peak (dopamine and serotonin). The developed and optimised separation method based on capillary zone electrophoresis and ultraviolet detection was capable to achieve detection limits at the concentration level in the range of 0.15 to 1.25 μg/mL−1. The developed method was also characterised by other favourable validation parameters, such as linearity (r
2 > 0.99), accuracy (82.9–117.8% for the intraday measurements, and 87.6–119.2% for the interday measurements), and precision (intraday relative standard deviation in the range of 0.4–15.5%, interday relative standard deviation in the range of 0.9–18.3%). The method was finally applied to investigate the stability of the analytes in model water matrix samples under various storage conditions.
Beyond traditional academic degrees: The labor market returns to occupational credentials in the United States
Authors: Baird Matthew D. , Bozick Robert , Zaber Melanie A. 
Published: August 2022

Abstract
Occupational credentials provide an additional—and, at times, alternative—path other than traditional academic degrees for individuals to increase productivity and demonstrate their abilities and qualifications to employers. In the United States, these credentials typically take the form of licenses and certifications. Although a critical part of the workforce landscape, the literature on the returns to credentials is inadequate, with prior research typically relying on Ordinary Least Squares (OLS) regressions which do not sufficiently control for selection. Using questions that identify credential receipt from the 2015 and 2016 United States’ Current Population Surveys, we construct an instrumental variable of local peer influence using the within-labor market credential rate of individuals sharing the same sociodemographic characteristics, while controlling for the same group's average wages and a suite of demographic and geographic controls. We use this instrument in a marginal treatment effects estimator, which allows for estimation of the average treatment effect and determines the direction of selection, and we estimate the effects of credentials on labor market outcomes. We find large, meaningful returns in the form of increased probability of individual employment, an effect which is concentrated primarily among women. The effect of having a credential on log wages is higher for those in the sub-baccalaureate labor market, suggesting the potential role of occupational credentials as an alternative path to marketable human capital and a signal of skills in the absence of a bachelor's degree.
Formal learning versus empirical learning: which one yields better results?
Authors: Lupulescu Mihnea Grigoraș Gîngioveanu 
Published: August 2022

Abstract
The digital revolution that we are currently experiencing is causing a lot of young people to ask themselves if formal education is still worth it. As the digital environment exponentially evolved in the last couple of years, you can now find almost any curriculum on the internet for a fraction of the price you would pay to study it in a university, or sometimes even free or charge. Furthermore, employers all over the globe are starting to put more emphasis on the experience accumulated by the individual rather than its formal studies, encouraging young people to start working early in their lives. The present paper approached this hypothesis from two different angles: the first part of the paper was focused on individuals in their early “work-life”, more precisely millennials that graduated recently, while the second part of the paper looked at the wealthiest people on the planet, the ones indicated by Forbes Top 30. Insights about how millennials with higher education see work in relation with their formal studies were obtained using a questionnaire, their overall feedback being a positive one, against all previous expectations. Also, interesting patterns emerged from the data about the Forbes Top 30 billionaires after researching their educational backgrounds. As it turns out, financial success is not necessarily correlated with formal studies, but links between high performance / innovative individuals and previous formal studies have been found.
Investigation of the 2019-2021 National Evaluation exam: A case study of high school admissions in Bucharest
Authors: Firescu Alexandra-Maria , Necula Marian , Băsu Cecilia Emanuela , Ardelean Andreea , Roşu Maria-Magdalena , Milea Eduard C. , Păun Mihaela 
Published: August 2022

Abstract
With knowledge being at the center of societal development, global policy forums, such as OECD, promote policies to improve national education systems. According to the most recent PISA evaluation, 40% of Romanian 15-year students are considered functionally illiterate. The Romanian education system’s mission to catch up with international standards was challenged by the policy shocks following the ongoing COVID-19 pandemic. In an attempt to adapt to the new situation, the Minister of Education implemented a substantial reduction of the curricula covered by the National Evaluation exam held in 2020. In 2021, the exam was restructured so to resemble the PISA tests. The purpose of this paper is to investigate how these changes have impacted the Romanian upper education system. We used the 2019-2021 high school admission data published by the Ministry of Education. Our results indicate apparent progress of high school efficacy due to the inflationary grade effects. We provided an alternative metric based not on grades but high school candidates’ rank. The classification of high schools based on this instrument is revealed as more robust. Most high schools in Bucharest run in the lowest performance category with the upper education system relying on a few top-performing high schools. For administrators and policymakers, this type of instrument is crucial for a proper evaluation of educational institution efficacy and authentic progress. This type of evaluation is the first action in the process to meet OECD requirements to close the gap between the lowest and highest education institutions in the EECA region.