bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short-term efficacy and safety of a lower dose of polyethylene glycol recombinant human growth hormone in children with growth hormone deficiency: A randomized, dose-comparison study
Authors: Jiang Zhouhong , Chen Xuefeng , Dong Guanping , Lou Yin , Zhang Jianping , Cheng Xinran , Pan Jiayan , Liao Wei , Wu Jinzhun , Huang Xiaodong , Jin Xianjiang , Liu Deyun , Zeng Ting , Zhu Shunye , Dong Qin , Luo Xiaoming , Lan Dan , Cao Lizhi , Zhang Xingxing , Liu Jing , Dai Mingjuan , Zhang Manyan , Liu Li , Dong Junhua , Zhao Dongmei , Ni Shaoqing , Fu Junfen 
Published: August 2022

Objective: Polyethylene glycol recombinant human growth hormone (PEG-rhGH, Jintrolong®) is the first long-acting rhGH preparation that is approved to treat children with growth hormone deficiency (GHD) in China. Clinical experience with dose selections of PEG-rhGH is scarce. The present study compared the efficacy and safety of a lower dose to increase dosing regimens of PEG-rhGH treatment.Methods: A multicenter, randomized, open-label, dose-comparison clinical study was conducted to compare the improvements in the height standard deviation score (Ht SDS), height velocity (HV), insulin-like growth factor-1 (IGF-1) SDS, and safety profiles of children with GHD who are treated with 0.2 mg/kg/week of PEG-rhGH dose or 0.14 mg/kg/week for 26 weeks.Results: Ht SDS, HV, and IGF-1 SDS increased significantly after PEG-rhGH treatment in the two dose groups (p &lt; 0.05). The improvements of Ht SDS, HV, and IGF-1 SDS were more significant in the high-dose group than in the low-dose group (p &lt; 0.05). Ht SDS improvement in low-dose group was not non-inferiority to that in the high-dose group (p = 0.2987). The incidences of adverse events were comparable between the two groups.Conclusion: The improvements of Ht SDS, HV, and IGF-1 SDS were more significant in the high-dose group than in the low-dose group (p &lt; 0.05). PEG-rhGH at the dose of 0.14 mg/kg/week was effective and safe for children with GHD.Clinical Trial Registration:clinicaltrials.gov, identifier NCT02908958.
The Chinese version of the family accommodation scale for obsessive-compulsive disorder self-rated: reliability, validity, factor structure, and mediating effect
Authors: Liao Zhenhua , Ding Lijun , You Ciping , Chen Ying , Zhang Wenchang 
Published: August 2022

BackgroundFamily accommodation (FA) in obsessive compulsive disorder (OCD) is a common phenomenon. Based on the cost of training interviewers and the time required to administer the scale, the Family Accommodation Scale for Obsessive-Compulsive Disorder Interviewer-Rated (FAS-IR) has been restricted to specific settings. A self-rated version of the family accommodation scale may solve these problems. The aim of this study was to examine the reliability, validity and factor structure of the Family Accommodation Scale Self-rated version (FAS-SR), and the relationship among FA, symptom severity and functional impairment.MethodsIn total, 171 patients with OCD and 145 paired relatives participated in this study. The Sheehan Disability Scale (SDS), Obsessive-Compulsive Inventory Revised (OCI-R), Zung Self-Rating Depression Scale (Zung-SDS), 12-item Family Assessment Devices (FAD-12), Clinical Global Impression of Severity Scale (CGI-S), Global Assessment of Functioning (GAF), and Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) were used as tools for patients. The FAS-SR, FAS-IR, FAD-12, and the patients’ symptom severity of Y-BOCS compulsion were used as tools for relatives. The psychometric properties of the FAS-SR were evaluated using Cronbach’s alpha coefficient, test-retest reliability and validity. Mediation analysis was used to determine the relationship among FA, symptom severity and functional impairment.ResultsA total of 97.9% of relatives of OCD patients reported at least one kind of FA behavior, and 56.6% of participants engaged in FA every day in the past week. The FAS-SR includes a three-factor structure: (1) providing reassurance and participation; (2) facilitation; and (3) modification. The scale’s Cronbach’s alpha and test-retest coefficients were 0.875 and 0.970, respectively. The total FAS-SR score was significantly positively associated with the Y-BOCS, FAD-12, CGI-S, FAS-IR, and SDS scores, and negatively associated with the total GAF score. FA partially mediated the relationship between symptom severity and functional impairment.ConclusionThe FAS-SR was proven to have satisfactory psychometric properties, and can play an important role in the evaluation and early intervention of OCD. This result indicates the importance of assessing symptom severity in conjunction with FA when evaluating OCD patients’ functional impairment.
High-risk population's knowledge of risk factors and warning symptoms and their intention toward gastric cancer screening in Southeastern China
Authors: Huang Zhiwen , Liu Wei , Marzo Roy Rillera , Hu Zhijian , Wong Li Ping , Lin Yulan 
Published: August 2022

BackgroundAs the incidence of gastric cancer (GC) increases sharply in adults aged over 40 years, screening of this high-risk population is important. This study aimed to explore knowledge level of GC related risk factors and symptoms, and to identify influencing factors associated with intention toward GC screening among people aged 40 years old and above in China.MethodsA cross-sectional, web-based survey was conducted among people aged 40 years old and above between October 2021 and March 2022 in Southeastern China. The participants' knowledge was assessed by a series of questions about risk factors (24-item scale) and warning symptoms (14-item scale).ResultsA total of 2547 complete responses were received. The mean age was 47.72 (±7.20) years and near 60% were male. Respondents had a moderate level of knowledge about risk factors and warning symptoms of GC. The total mean knowledge score was 23.9 (±9.8) out of a possible score of 38. Majority (80%) of respondents reported intention to be screened for GC in the next 5 years. The most influential predictors of screening intention were income level (OR = 2.13, 95% CI: 1.36–3.32), perceived benefits (OR = 1.99, 95% CI: 1.33–2.73), perceived severity (OR = 1.68, 95% CI: 1.20–2.34), ever took GC screening (OR = 1.63, 95% CI: 1.28–2.08), perceived poor overall health (OR = 1.59, 95% CI: 1.19–2.11), and perceived barriers (OR = 1.56, 95% CI: 1.17–2.09). Other significant factors were ever diagnosed with chronic gastric diseases, total knowledge score, and cues-to-action. The major reasons for not willing to take screening were “endoscopy is uncomfortable” (29.6%), “worry about screening results” (23.6%), and “have no symptoms” (21.3%).ConclusionHigh-risk population aged 40 years and above expressed high intention to receive GC screening. Intervention to improve health promotion and reduce the barriers to uptake of GC screening among high-risk populations in China is warranted.
Effects of exercise on sleep spindles in Parkinson's disease
Authors: Memon Adeel Ali , Catiul Corina , Irwin Zachary , Pilkington Jennifer , Memon Raima A. , Joop Allen , Wood Kimberly H. , Cutter Gary , Bamman Marcas , Miocinovic Svjetlana , Amara Amy W. 
Published: August 2022

BackgroundIn a randomized, controlled trial, we showed that high-intensity rehabilitation, combining resistance training and body-weight interval training, improves sleep efficiency in Parkinson's disease (PD). Quantitative sleep EEG (sleep qEEG) features, including sleep spindles, are altered in aging and in neurodegenerative disease.ObjectiveThe objective of this post-hoc analysis was to determine the effects of exercise, in comparison to a sleep hygiene, no-exercise control group, on the quantitative characteristics of sleep spindle morphology in PD.MethodsWe conducted an exploratory post-hoc analysis of 24 PD participants who were randomized to exercise (supervised 3 times/week for 16 weeks) versus 26 PD participants who were assigned to a sleep hygiene, no-exercise control group. At baseline and post-intervention, all participants completed memory testing and underwent polysomnography (PSG). PSG-derived sleep EEG central leads (C3 and C4) were manually inspected, with rejection of movement and electrical artifacts. Sleep spindle events were detected based on the following parameters: (1) frequency filter = 11–16 Hz, (2) event duration = 0.5–3 s, and (3) amplitude threshold 75% percentile. We then calculated spindle morphological features, including density and amplitude. These characteristics were computed and averaged over non-rapid eye movement (NREM) sleep stages N2 and N3 for the full night and separately for the first and second halves of the recording. Intervention effects on these features were analyzed using general linear models with group x time interaction. Significant interaction effects were evaluated for correlations with changes in performance in the memory domain.ResultsA significant group x time interaction effect was observed for changes in sleep spindle density due to exercise compared to sleep hygiene control during N2 and N3 during the first half of the night, with a moderate effect size. This change in spindle density was positively correlated with changes in performance on memory testing in the exercise group.ConclusionsThis study is the first to demonstrate that high-intensity exercise rehabilitation has a potential role in improving sleep spindle density in PD and leading to better cognitive performance in the memory domain. These findings represent a promising advance in the search for non-pharmacological treatments for this common and debilitating non-motor symptom.
Job Leaving Intentions of Dentists Associated With COVID-19 Risk, Impact of Pandemic Management, and Personal Coping Resources
Authors: Pacutova Veronika , Madarasova Geckova Andrea , Majernikova Sara Maria , Kizek Peter , de Winter Andrea F. , Reijneveld Sijmen A. 
Published: August 2022

Objectives: The COVID-19 pandemic caused risks and burdens for health professionals and might result in job leaving intentions. To assess the potential risks, we explored the association of the job leaving intentions with exposure to COVID-19 risk, impact of pandemic management on professional and personal life, and personal coping resources among Slovak dentists in the first wave of the outbreak.Methods: We obtained data from 500 dentists (66.8% females, M/SD = 43.8) registered with the Slovak Chamber of Dentists using an online questionnaire. Data were analysed using logistic regression models adjusted for age and gender.Results: Nearly 40% of dentists reported job leaving intentions after the first wave of the pandemic outbreak. Job leaving intentions were associated with exposure to COVID-19 risks (odds ratios, ORs, varying from 1.6 to 4.7), impact of pandemic management on professional and personal life (Ors from 1.6 to 2.9), and personal coping resources (Ors from 0.4 to 0.6).Conclusion: Better management of exposures to risks and impact on professional and personal life, as well as building better personal coping resources may prevent the loss of a valuable workforce in dental care.
Produções científicas acerca da atenção à crise em saúde mental nos serviços de urgência e emergência
Authors: Wasum Fernanda Demetrio , Zubiaurre Priscila de Melo , Silveira Rafael Pasche da , Anacleto Maria Luíza Alves , Flores Alexandra do Nascimento Damasio , Xavier Mariane da Silva , Oliveira Marcia Aparecida Ferreira de , Siqueira Daiana Foggiato de 
Published: August 2022

Introdução: A atenção à saude mental está em constante transformações, principalmente após a Reforma Psiquiátrica e a Lei 10.216 de abril de 2001, as quais visam redirecionar o modelo assistencial para um modelo de tratamento humanizado e respeitoso com o sujeito em sofrimento. Sabe-se que há dificuldades na assistência dos profissionais com usuários em crise psíquica, no que tange o acolhimento e o processo de ressignificação. O acolhimento dessas crises pode ocorrer em diferentes pontos da Rede de Atenção Psicossocial (RAPS), porém identifica-se na atuação dos profissionais dos serviços de urgência e emergência um significativo despreparo atrelado a estigmas referentes a loucura. Método: O trabalho consiste em uma revisão narrativa da literatura. A busca foi realizada no portal de teses e dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) em maio de 2022, visando analisar o estado da arte. Resultados e Discussão: Foram selecionados 16 artigos para compor o corpus do estudo. Evidenciou-se o despreparo dos profissionais em manejar as crises em saúde mental, fato que pode ter sua gênese atrelada a carência de ações de educação continuada e educação permanente em saúde com as equipes. Conclusão: Nesse contexto, ações de educação permanente em saúde são fundamentais para transformar esse cenário e fomentar práticas assistenciais humanizadas entre os profissionais.
AVANCE GENÉTICO ESPERADO PARA APTITUD COMBINATORIA. MODELO CON ALELOS MÚLTIPLES Y PROBADORES HOMOCIGÓTICOS
Authors: Sahagún-Castellanos Jaime 
Published: August 2022

El modelo de dos alelos por locus puede resultar limitado para el estudio teórico de poblaciones formadas por los cruzamientos de tres o más progenitores o de poblaciones de polinización libre. Ignorar esta insuficiencia de este modelo en ocasiones puede conducir a resultados que, a su vez, pueden orientar deficientemente al fitomejorador en la conducción de un programa de mejoramiento genético. Por otra parte, la teoría clásica del mejoramiento de la aptitud combinatoria fue derivada con base en un modelo de sólo dos alelos. Este estudio se diseñó para derivar la respuesta a la selección para aptitud combinatoria (R) de una población de líneas con un coeficiente de endogamia F, alelos múltiples y probadores homocigóticos. Se encontró que la R tiene una relación directa con F y que depende de la varianza genética aditiva ( σ 2 A ) y de la covarianza entre los valores aditivos y las desviaciones de dominancia de los mestizos ( σ A,DMu ). Además, el análisis efectuado mostró que σ A,DMu puede determinar la existencia de una R negativa y hacer que la varianza genética de los mestizos sea cero. El límite mínimo de σ A,DMu es − (1/ 4)σ 2A − (1/ 2)σ 2DMu , donde σ 2DMu es la varianza de los mestizos. También se encontró que cuando los resultados obtenidos se expresaron en términos de sólo dos alelos, se produjo una coincidencia completa con los resultados que para este caso ya se habían derivado con un enfoque diferente. En particular, se encontró que la R es negativa si con sobredominancia positiva, d = ka (k>1), [(k-1)/(2k)]<q<1 y si es con sobredominancia negativa, d = ka (k<-1), 0<q<[(k+1)/(2k)]. Aquí, q, d y a representan la frecuencia de A2 y los valores genotípicos de A1A2 y A1A1, respectivamente.
No Palácio de Lótus
Authors: Lima da Silva Higor 
Published: August 2022

No cotidiano mundial, por conta das mortes pelo coronavírus, os afetos que coexistem com o luto ficaram mais presentes na memória coletiva. Com efeito, o presente poema parte de uma aisthesis a uma kátharsis para trazer ao leitor uma experiência estética do livramento do sofrimento de estar separado de quem se ama. E é considerando que neste ano se comemora os 800 anos de nascimento do Grande Mestre Nitiren Daibossatsu, que é muito importante ao Budismo, que o poema em homenagem a ele traz um léxico que reflete seus ensinamentos. Portanto, em suma, “Palácio de Lótus” significa “templo budista” (Nitiren ensinou o Sutra Lótus); “kalpas” é uma medida de tempo praticamente incalculável; “Gohonzon” é a Mandala Sagrada da prática do Sutra Lótus; “Saha” refere-se ao mundo dos humanos; “quatro mares” refere-se a um país, ao mundo ou aos mares entorno de Sumeru (nome de uma montanha tanto física quanto espiritual); “cisne” simboliza um ser que vive em partida e distanciamento de quem ama; “bossatsu” é o estado de pleno altruísmo onde se almeja mais a iluminação alheia do que a própria; “branco” representa a morte, luto e sofrimento; “sakura” é traduzida por cerejeira (os japoneses esperam anualmente a alegria de vê-la florescer, mas sua floração bela é curta e frágil, trazendo melancolia pela efemeridade); “lanternas” são as lanternas flutuantes; e a “lua” representa os ensinamentos budistas.
Polityczność pragnienia w myśli Spinozy: przeciwko antynomicznej interpretacji Leszka Kołakowskiego
Authors: Januszkiewicz Antonina 
Published: August 2022

Artykuł ukazuje polityczność ontologicznego systemu Benedykta Spinozy na przykładzie pojęcia conatus (pragnienia). Autorka broni spójności myśli niderlandzkiego myśliciela polemizując z interpretacją Leszka Kołakowskiego, podług której system Spinozy charakteryzują nieprzezwyciężalne antynomie jednostki i nieskończoności. Jak zostaje wykazane w tekście artykułu, dostrzeżenie fundamentalnie politycznego charakteru ontologicznych pojęć Spinozy pozwala przekroczyć owe antynomie w kierunku spójnej i klarownej interpretacji. Skupiając ciężar wywodu na pojęciu conatus, autorka poddaje analizie dwie antynomie Kołakowskiego. Pierwsza z nich dotyczy problemu trwania i jednostkowości i przedstawia pozorną sprzeczność pomiędzy zasadą samozachowania indywiduów a niepodzielnością substancji. Druga zaś, dotyka kwestii ściśle etycznej – rzekomej niezgodności pomiędzy pragnieniem zachowania się w swym istnieniu a pragnieniem intelektualnej miłości Boga. Autorka wykazuje, że podstawą obydwu antynomii jest zapoznanie polityczności pojęcia conatus, a wraz z nim politycznego wymiaru Etyki.
BERPIKIR POSITIF PADA HADITS “ANĀ ‘INDA ZHANNĪ ‘ABDI BĪ” DALAM PERSPEKTIF GRAMATIKA DAN BALAGHAH
Authors: Yusra Oktarina Rina 
Published: August 2022

<p style="text-align: justify;"><em>This study aims to analyze positive thinking in the hadith "ana 'inda zhanni 'abdi bi" in a grammatical and balaghah perspective. The diction of the hadith confirms that Allah will actually realize what His servant thinks of him, both positive and negative because there is taukid namely dhamir al-fashl at the beginning of the hadith and ismiyyatul jumlah which strengthens jumlah khabariyah. However, if it is examined from a grammatical and balaghah perspective, the hadith contains an invitation to think positively, not negatively. This research is library research by examining books and scientific works related to the title. The authors found that the hadith is included in the chapter on the invitation to remember Allah from this study. Allah warns His servants to be careful in prejudice or thinking of Him because He is present, close, closely attached to what is suspected or thought by the servant, and is easily able to realize what is suspected or thought. As a "closeness" and "specialization" for 'abdu (obedient and submissive servant), Allah invites His servants to think positively, remember Him, draw closer to Him, and come to Him. Then He will reward the servant with good rewards that will lead him to success in this world and the hereafter. In the hadith there are taukid, tahriku al-himmah ila ma yalzamu tahshiluhu, ziyadatu at-taqrir wa al-idhah li as-sami', ta'jilu al-masarrah, azh-zharfu li hudhuri asy-sya'i wa dunuwwihi, al -yaqin billahi, wa at-takhshishu li al-'abdi al-khadhi' li rabbihi al-mustaslimi al-munqadi li amrihi and al-ilshaq. Therefore, every servant should try always to think positively.</em><strong></strong></p>
Development of Short-Term Forecasting Models Using Plant Asset Data and Feature Selection
Authors: Walker Cody , Ramuhalli Pradeep , Agarwal Vivek , Lybeck Nancy , Taylor Mike 
Published: August 2022

Nuclear power plants collect and store large volumes of heterogeneous data from various components and systems. With recent advances in machine learning (ML) techniques, these data can be leveraged to develop diagnostic and short-term forecasting models to better predict future equipment condition. Maintenance operations can then be planned in advance whenever degraded performance is predicted, thus resulting in fewer unplanned outages and the optimization of maintenance activities. This enables lower maintenance costs and improves the overall economics of nuclear power.
This paper focuses on developing a short-term forecasting process that leverages a feature selection process to distill large volumes of heterogeneous data and predict specific equipment parameters. A variety of feature selection methods, including Shapley Additive Explanations (SHAP) and variance inflation factor (VIF), were used to select the optimal features as inputs for three ML methods: long short-term memory (LSTM) networks, support vector regression (SVR), and random forest (RF). Each combination of model and input features was used to predict a pump bearing temperature both 1 and 24 hours in advance, based on actual plant system data. The optimal inputs for the LSTM and SVR were selected using the SHAP values, while the optimal input for the RF consisted solely of the response variable itself. Each model produced similar 1-hour-ahead predictions, with root mean square errors (RMSEs) of roughly 0.006. For the 24-hour-ahead predictions, differences could be seen between LSTM, SVR, and RF, as reflected by model performances of 0.036 +- 0.014, 0.0026 +- 0, and 0.063 +- 0.004 RMSE, respectively. As big data and continuous online monitoring become more widely available, the proposed feature selection process can be used for many applications beyond the prediction of process parameters within nuclear infrastructure.
Ethics and the explainable artificial intelligence(XAI) movement
Authors: Adamson Greg 
Published: August 2022

<p>Since 2016 a significant program of work has been developed under the title of explainable artificial intelligence (XAI). This program, prompted and extensively funded by DARPA, has sought to address the reasoning behind decisions or recommendations of AI systems. As AI systems often have concealed or <em>black box</em> characteristics, the problem of explainability is a significant challenge. XAI has been described as a movement rather than a single technology approach. Many thousands of papers have examined the problem, and diverse approaches have been put forward. One approach encouraged by DARPA has since become known as post-hoc reasoning, applying inductive reasoning. This research examines the claim to accuracy of post-hoc explanations, applying the perspective of the philosophy of technologyAs AI systems are already being used to determine who should have access to scarce resources and who should be punished and in what way, the accuracy of an explanation is an important ethical issue. . This paper asserts that technologists as experts in AI technology hold a unique ethical responsibility to clarify to a wider audience the limitations of knowledge about the workings of black box AI systems, and to avoid narratives that encourage uncritical acceptance of technology promise. The paper also proposes practical ways in which to approach the use of post-hoc reasoning where appropriate. </p>