bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and Development a Mobile-Based Self-Care Application for Patient with Depression and Anxiety Disorders: An applied and developmental study
Authors: Moulaei Khadijeh , Bahaadinbeigy Kambiz , Mashoof Esmat , Dinari Fatemeh 
Published: November 2022

Abstract
Background and Aim

Depression and anxiety can cause social, behavioral, occupational and functional impairments if not controlled and managed. Mobile-based self-care applications can be used as an important and effective factor in controlling and reducing the effects of anxiety disorders and depression. The aim of this study was to design and development a mobile-based self-care application for patient with depression and anxiety disorders.

Materials and methods

In this applied - developmental study we designed a mobile-based application for self -management of depression and anxiety disorders. In order to design this application, first the education- informational needs and capabilities were identified through a systematic review. Then, according to 20 patients with depression and anxiety, this education-informational needs and application capabilities were approved. In the next step, the application was designed.

Results

Of 80 education- informational needs and capabilities, 69 needs and capabilities with a mean greater than and equal to 3.75 (75%) were considered in application design. Disease control and management, drug management, nutrition and diet management, recording clinical records, communicating with physicians and other patients, reminding appointments, how to improve lifestyle, quitting smoking and reducing alcohol consumption, educational content, sedation instructions, introducing health care centers for depression and anxiety treatment and recording activities, personal goals and habits in a diary were the most important features of this application.

Conclusion

The designed application can improve self-care among people with depressive and stress disorders and help patients to access the information they need without search the Internet.
calf – software for CEST analysis with Lorentzian fitting
Authors: Wittsack Hans-Jörg , Radke Karl Ludger , Stabinska Julia , Ljimani Alexandra , Müller-Lutz Anja 
Published: November 2022

AbstractAnalysis of chemical exchange saturation transfer (CEST) MRI data requires sophisticated methods to obtain reliable results about metabolites in the tissue under study. CEST generates z-spectra with multiple components, each originating from individual molecular groups. The individual lines with Lorentzian line shape are mostly overlapping and disturbed by various effects. We present an elaborate method based on an adaptive nonlinear least squares algorithm that provides robust quantification of z-spectra and incorporates prior knowledge in the fitting process. To disseminate CEST to the research community, we developed software as part of this study that runs on the Microsoft Windows operating system and will be made freely available to the community. Special attention has been paid to establish a low entrance threshold and high usability, so that even less experienced users can successfully analyze CEST data.
Role of NFAT4-Trim17 axis mediates the neuronal apoptosis after subarachnoid hemorrhage
Authors: Song Shibin , Zhou Xiaoming , Qiu Wenjin , Xu Zhixiong , Dong Minghao , Chen Yimin , Yang Hua 
Published: November 2022

Abstract

Background:Although accumulating evidence indicates that Trim17 is implicated in the pathophysiology of neuronal apoptosis, the regulation mechanism on pro-apoptotic role of Trim17 after subarachnoid hemorrhage (SAH) has not been well identified so far.Methods:Trim17 siRNA was administered to explore the detrimental role of Trim17 in mediating neuronal apoptosis in vivo and in vitro after experimental SAH. The nuclear factor of activated T cells (NFAT) signaling, involving in the underlying regulation mechanism on Trim17, was further explored.Results:Trim17 mainly located in the neurons and presented an obvious elevated expression in vivo and in vitro after SAH. Trim17 siRNA administration could significantly ameliorate neuronal apoptosis after SAH. Moreover, inhibition the nuclear translocation of NFAT4 could effectively abolishthe pro-apoptotic activity of Trim17/Bax pathway, accompanied by ameliorated neuronal apoptosis and improved neurological function.Conclusions:The elevation of Trim17 is sufficient for triggering the intrinsic apoptotic effect after SAH, and this pro-apoptotic activity could be mediated by the initiated of the nuclear translocation of NFAT4. Pharmacological targeting of NFAT4/Trim17 pathway can be explored for SAH therapy.
Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response
Authors: Arora Rohit , Cao Christian , Kumar Mehul , Sinha Sarthak , Chanda Ayan , McNeil Reid , Samuel Divya , Arora Rahul , Matthews Wayne , Chandarana Shamir , Hart Robert , Dort Joseph , Biernaskie Jeff , Neri Paola , Hyrcza Martin , Bose Pinaki 
Published: November 2022

Abstract
We performed the first integrative single-cell and spatial transcriptomic analysis on HPV-negative oral squamous cell carcinoma (OSCC) to comprehensively characterize tumor core (TC) and leading edge (LE) transcriptional architectures. We show that the TC and LE are characterized by unique transcriptional profiles, cellular compositions, and ligand-receptor interactions. We demonstrate that LE regions are conserved across multiple cancers while TC states are tissue specific, highlighting the existence of common mechanisms underlying tumor progression and invasion. Additionally, we found that a LE gene signature is associated with worse clinical outcomes while a TC gene signature is associated with improved prognosis across multiple cancer types. Finally, using an in silico modeling approach, we describe spatially-regulated patterns of cell development in OSCC that are predictably associated with drug response. Our work provides pan-cancer insights into TC and LE biology and an explorable atlas (http://www.pboselab.ca/spatial_OSCC/) that can be foundational for developing novel targeted therapies.
Pan-cancer Analysis Predicts Kindlin-associated Global
Mechanochemical Perturbation
Authors: Haldar Shubhasis , Chowdhury Debojyoti , mistry ayush , Bhatia Riti , Wadan Simran , Chakraborty Soham 
Published: November 2022

Abstract
Kindlins are mechanosensitive adapter proteins that connect extracellular mechanical cues to intracellular chemical events. Any alterations in these proteins thus alter cellular signaling, which could result in cancer progression. However, their involvement in global mechanochemical signals remains elusive in cancers. Here we analyze pan-cancer samples to decipher how kindlin alterations aid cancer progression. We show that kindlin alterations, at both the genetic and mRNA level, dysregulates cellular behavior which significantly correlate with poor survival. We find that while these alterations are cancer-specific, they are prevalent in advanced tumor stages and metastatic onset. We observe that kindlins co-alter with a substantial fraction of human mechanochemical proteome in various tumors. Our analysis suggests how kindlin alterations aid tumor-promoting signals with a synergistic effect from alterations of cancer-hallmark genes. Notably, we demonstrate a consistent alteration of epithelial-mesenchymal-transition markers with kindlin activity. Overall, our study highlights how kindlin alterations could affect metabolism, genomic instability, and signal disruption via their interactome network, causing cancer and suggests targeting them as a therapeutic strategy.
Probing energy transition-environmental sustainability hypothesis in post COP26 era: Do technological advancement, structural change, and demographic mobility matter for G7?
Authors: Ibrahim Ridwan Lanre , Al-mulali Usama , Solarin Sakiru Adebola , Ajide Kazeem Bello , Al-Faryan Mamdouh Abdulaziz Saleh , Mohammed Abubakar 
Published: November 2022

Abstract
Global warming remains the most devastating environmental issue embattling the global economies, with significant contributions emanating from CO2 emissions. The continued rise in the level of greenhouse gas (GHG) emissions serves as a compelling force which constitutes the core discuss at the recent COP26 prompting nations to commit to the net zero emissions target. The current research advances the first empirical investigation on the roles of structural change, demographic mobility, and energy transition in G7 pathways to environmental sustainability captured by CO2 emissions per capita (PCCO2) in G7 economies from the empirical perspective. The study considers the additional impacts of resource abundance and technology. The empirical backings are subjected to pre-estimation tests consist of cross-sectional dependence, second-generation stationarity, and panel cointegration tests. The model estimation is based on Cross-Sectional Augmented Autoregressive Distributed Lag, Dynamic Common Correlated Effects Mean Group, and Augmented Mean Group for the main analysis and robustness checks. The findings reveal the existence of EKC based on the direct and indirect effects of the components of economic growth. The indicators of demographic mobility differ in the direction of influence on PCCO2. For instance, while rural population growth negatively influences PCCO2 in the short-run alone, urban population growth increases PCCO2 in the short-run and long-run periods. Nonrenewable energy, information computer technology (ICT) imports, and mobile cellular subscriptions serve as positive predictors of PCCO2, while ICT exports and renewable energy moderate the surge in PCCO2. Policy implications that enhance environmental sustainability are suggested following the empirical verifications.
Effects of diurnal temperature range on Intracerebral hemorrhage among middle-aged and elderly people in Central China
Authors: Wang Shiwen , Zhou Hao , Lai Jingmin , Xiao Guizhen , Tong Zhuoya , Deng Jing , Yang Fang , Shi Qianshan , Shi Jingcheng 
Published: November 2022

Abstract
Objective
This study aimed to evaluate the effect of diurnal temperature range (DTR) on the number of admissions for intracerebral hemorrhage (ICH) in middle-aged and elderly population.
Methods
We collected DTR and the diurnal hospital admission data of patients with ICH over 45 years old, as well as mixed factors such as meteorology and air pollutants in Hunan Province during 2019 as a representative area of central China and analyzed with a distributed lag nonlinear model.
Results
In total, there were 54 690 ICH admissions in Hunan Province with 30.76% in middle-aged and 69.24% in the elderly. After controlling for other confounding factors, this study found that there was a non-linear relationship between DTR and the number of ICH hospital admissions in middle-aged and elderly groups. In spring, low DTR(middle-aged < 3℃, elderly < 4℃) with continuous low temperature will increase the risk of ICH admissions in both middle-aged and elderly groups ,while high DTR only increase the middle-aged admission risk; Low DTR with continuous high temperature will increase the risk of ICH admissions only in the middle-aged during summer; Autumnal high DTR also caused high risk in both groups; Low DTR(< 3℃) with continuous low temperature or high DTR will increase the risk only in elderly groups in winter. In the elderly groups, the effect of DTR occurs within 5 days, but occurs after 11 days in the middle-aged group.
Conclusion
High DTR may increase the risk of ICH admissions in middle-aged and elderly groups in central China, and elderly group is more sensitive to the impact of DTR. The risk effect of DTR on ICH was significantly different in different seasons between different groups. It is recommended that DTR values should be reported and highlighted in weather forecasting services, with specific interventions targeting sensitive populations.
Polysubstance Mortality Trends in White and Black Americans during the Opioid Epidemic, 1999-2018
Authors: Rawy Marwa , Abdalla Gergis , Look Kevin 
Published: November 2022

Abstract
Background
Psychoactive drug combinations are increasingly contributing to overdose deaths among White and Black Americans. To understand the evolving nature of overdose crisis, inform policies, and develop tailored and equitable interventions, this study provides a comprehensive assessment of polysubstance mortality trends by race and sex during the opioid epidemic.
Methods
We used serial cross-sectional US mortality data for White and Black populations from 1999 through 2018 to calculate annual age-adjusted death rates (AADR) involving any opioid, opioid subtypes, benzodiazepines, cocaine, psychostimulants, or combinations of these drugs, stratified by race and sex. Trend changes in AADR were analyzed using joinpoint regression models and expressed as average annual percent change (AAPC) during each sub-period of the three waves of the opioid epidemic: 1999–2010 (wave 1), 2010–2013 (wave 2), and 2013–2018 (wave 3). Prevalence measures assessed the percent co-involvement of an investigated drug in the overall death from another drug.
Results
Polysubstance mortality has shifted from a modest rise in death rates due to benzodiazepine-opioid overdoses among White persons (wave 1) to a substantial increase in death rates due to illicit drug combinations impacting White and Black populations (wave 3). Concurrent cocaine-opioid use had the highest polysubstance mortality rates in 2018 among Black (5.28 per 100,000) and White (3.53 per 100,000) persons. The steepest increase in death rates during wave 3 was observed across all psychoactive drugs when combined with synthetic opioids in both racial groups. Since 2013, Black persons have died faster from cocaine-opioid and psychostimulant-opioid overdoses. Between 2013 and 2018, opioids were highly prevalent in cocaine-related deaths, increasing by 33% in White persons compared to 135% in Blacks. By 2018, opioids contributed to approximately half of psychostimulant and 85% of benzodiazepine fatal overdoses in both groups. The magnitude and type of drug combinations with the highest death rates differed by race and sex, with Black men exhibiting the highest overdose burden beginning in 2013.
Conclusions
The current drug crisis should be considered in the context of polysubstance use. Effective measures and policies are needed to curb synthetic opioid-involved deaths and address disparate mortality rates in Black communities.
Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity
Authors: Letsinger Ayland C. , Ward James M. , Fannin Rick D. , Mahapatra Debabrata , Bridge Matthew F. , Sills Robert C. , Gerrish Kevin E. , Yakel Jerrel L. 
Published: November 2022

Abstract

Individuals infected by SARS-CoV-2 are at risk of developing neurological-related post-acute disorders. Disputed epidemiological data indicated nicotine may reduce the severity of infection. Here we find exposure to nicotine in drinking water does not alter the moribundity of hACE2 mice. However, pre-exposure to nicotine decreased the likelihood of SARS-CoV-2 RNA expression and pathology in the brain. These results suggest mechanisms involving targets of nicotine could be leveraged to prevent the neurovirulence of SARS-CoV-2.
Integrating qualitative and quantitative data in sport injury research: An interdisciplinary procedure
Authors: Hausken-Sutter Solveig Elisabeth , af Gennäs Klara Boije , Schubring Astrid , Grau Stefan , Jungmalm Jonatan , Barker-Ruchti Natalie 
Published: November 2022

AbstractBackground To understand and prevent sport injuries, scholars have employed different scientific approaches and methods. Traditionally, this research has been monodisciplinary, focusing on one subdiscipline of sport science and applying qualitative or quantitative methods. Recently, scholars have argued that traditional approaches fail to address the complexity of sport injuries, and, as a way forward, have called for pluralistic approaches involving the application of both qualitative and quantitative methods. At present, pluralist sport injury research is at the theoretical level and best practice examples are rare. Therefore, the purpose of this paper is to (1) outline the Interdisciplinary Case Analysis Procedure (ICAP); and (2) provide implications for future interdisciplinary sport injury analysis. Method We adopt an established definition and operationalisation of interdisciplinary research and a case study approach to develop and pilot the ICAP for qualitative and quantitative sport injury datasets. The development and piloting of ICAP was possible with the use of injury datasets from the interdisciplinary research project “Injury-free children and adolescents: Towards better practice in Swedish football” (the FIT project). All methods were carried out in accordance with relevant guidelines. Result The ICAP consists of three stages and works as a guide for interdisciplinarity, where the team first creates a common ground and a more comprehensive understanding of sport injuries; second, collates analysed qualitative and quantitative sport injury data into a multilevel data catalogue; and third, conducts an integrated discussion of data. Conclusion The integrated discussion is key to create new insights into sport injury aetiology and requires researchers to be creative, flexible, and acknowledge other scientific perspectives throughout the procedure. The ICAP strengthens the integrated analysis of qualitative and quantitative data and may be applied to address other complex phenomena.
Timeliness and completeness of weekly surveillance data reporting on epidemic prone diseases in Uganda, 2020–2021
Authors: Nansikombi Hildah Tendo , Kwesiga Benon , Aceng Freda L. , Ario Alex R. , Bulage Lilian , Arinaitwe Emma S. 
Published: November 2022

Abstract

Introduction: Disease surveillance provides vital data for disease prevention and control programs. Incomplete and untimely data are common challenges in planning, monitoring, and evaluation of health sector performance, and health service delivery. Weekly surveillance data are sent from health facilities using mobile tracking (mTRAC) program, and synchronized into the District Health Information Software version 2 (DHIS2). The data are then merged into district, regional, and national level datasets. We described the completeness and timeliness of weekly surveillance data reporting on epidemic prone diseases in Uganda, 2020–2021. Methods We abstracted data on completeness and timeliness of weekly reporting of epidemic-prone diseases from 146 districts of Uganda from the DHIS2.Timeliness is the proportion of all expected weekly reports that were submitted to DHIS2 by 12:00pm Monday of the following week. Completeness is the proportion of all expected weekly reports that were completely filled and submitted to DHIS2 by 12:00pm Wednesday of the following week. We determined the proportions and trends of completeness and timeliness of reporting at national level by year, health region, district, health facility level, and facility ownership. Results National average reporting timeliness and completeness was 44% and 70% in 2020, and 49% and 75% in 2021. Eight of the 15 health regions achieved the target for completeness of ≥ 80%; Lango attained the highest (93%) in 2020, and Karamoja attained 96% in 2021. None of the regions achieved the timeliness target of ≥ 80% in either 2020 or 2021. Kampala District had the lowest completeness (38% and 32% in 2020 and 2021, respectively) and the lowest timeliness (19% in both 2020 and 2021). Referral hospitals and private owned health facilities did not attain any of the targets, and had the poorest reporting rates throughout 2020 and 2021. Conclusion Weekly surveillance reporting on epidemic prone diseases improved modestly over time, but timeliness of reporting was poor. Further investigations to identify barriers to reporting timeliness for surveillance data are needed to address the variations in reporting.
Sensitivity of acidified tamponed antigens in quality control test validation methodologies
Authors: Dias Anderson Silva , Galvão Mayra de Freitas , de Faria Guilherme Canhestro , Caldeira George Afonso Vitor 
Published: November 2022

Abstract
Brucellosis is responsible for great economic losses and because it is a zoonotic, chronic, infectious, contagious disease, there is a great interest in its eradication in the cattle rearing in Brazil. One of the most effective measures to combat it is the vaccination of the animals and the diagnosis of positive animals, which contributes to the sanitation of the rearing. For this, it is necessary to use a practical, accessible, rapid and sensitive diagnostic methodology. The objective of this study was to evaluate the uncertainty of the test of relative activity (sensitivity) for acidified tamponed antigen (ATA). This antigen is used for the diagnosis of Brucellosis caused by smooth strains of Brucella ssp. Thus, we verified the efficacy of some parameters such as selectivity, precision (limit of detection and intermediate accuracy) and reproducibility. In the analyzes performed in the tests, the performances of standard antigens were considered. It was verified that the acidified tamponed antigen quality control method showed adequate selectivity, limit of detection, intermediate accuracy, repeatability and reproducibility in the verification of sensitivity tests for brucellosis antigens in the LFDA-MG. No difference was verified in the results of the various replicates. The ATA test, using a stable and sensitive antigen that shows high agreement with the confirmatory test, has a high potential to contribute to the identification of positive animals and sanitation of the herd, as well as to reduce the frequency of brucellosis and its subsequent eradication of the bovine herd.