bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report of Sotalol Induced IgA Vasculitis
Authors: Mohammed Biniyam T. , Alchalabi Marwah , Laskova Anna , Sun Chenyu , Lodhi Owais , Gerais Yasmin , Abdelrahman Alkhidir Ayah Galal 
Published: June 2022

Background:
IgA vasculitis is the most common form of systemic vasculitis in children
but can occur in adults. Inciting antigens include infections, drugs, foods, insect bites, and immunizations.
Antibiotics and tumor necrosis factor (TNF) alpha inhibitors are the most common class of
drugs that cause IgA vasculitis. Although sotalol and rivaroxaban have been documented to cause
leukocytoclastic vasculitis, we have never come across any literature attributing IgA vasculitis to
either drug. Additionally, Rocky Mountain spotted fever has not been associated with IgA vasculitis
despite being described in cutaneous and systemic vasculitis cases. Here, we present a case of IgA
vasculitis triggered by sotalol with challenging differentials, including a recent infection with Rocky
Mountain spotted fever, malignancy, and rivaroxaban as possible triggers.

Case Presentation:
68 yr old male with a history of lung cancer treated with resection and chemotherapy
5 years ago is currently in remission, and recently was started on sotalol and rivaroxaban for
new-onset paroxysmal atrial fibrillation. He presented with diffuse petechial/purpural rash on the
lower limbs, multiple joint pain, severe abdominal pain and rectal bleeds, hemoptysis, and renal
dysfunction. IgG titers for RMSF were high. Punch biopsy of skin and renal biopsy were consistent
with IgA vasculitis. Sotalol and rivaroxaban were stopped. The patient was treated with oral prednisone,
and his condition relatively improved.

Conclusion:
Ig A vasculitis is mostly a self-limiting disease, but adults tend to have a severe
course. It is important to diagnose early and identify a trigger. Removing the offending agent or
treating the underlying infection is an important aspect of management.
PSSD and Biologic Therapy: Real-Life Data in 417 Patients with Moderate
to Severe Psoriasis
Authors: Proietti Ilaria , Bernardini Nicoletta , Skroza Nevena , Mambrin Alessandra , Tolino Ersilia , Marchesiello Anna , Marraffa Federica , Rossi Giovanni , Volpe Salvatore , Potenza Concetta 
Published: June 2022

Background:
Psoriasis is a chronic relapsing immune‐mediated disease leading to a strong impact on patient’s quality of life. The treatment of psoriasis has undergone a revolution with the advent of biologic therapies. Currently, Psoriasis Area and Severity Index [PASI] and Dermatology Life Quality Index [DLQI] scores are in use to assess the overall severity of pathology. A new self- administered questionnaire, the Psoriasis Symptoms and Signs Diary (PSSD), assesses severity of six psoriasis symptoms (itch, skin tightness, burning, stinging, and pain,) and five signs (dryness, cracking, scaling, shedding/flaking, redness, and bleeding).

Objective:
To evaluate and compare the efficacy of biologic therapies through PSSD in patients with moderate to severe psoriasis.

Methods:
The PSSD questionnaire was administered to all the patients at the beginning and after 6 months of biologic therapy (anti-TNFalpha, anti- IL17, anti-IL23, anti-IL12/23 and phhosphodiesterase-4 Inhibitors).

Results:
The study population included 417 adult patients with moderate to severe psoriasis in treatment with biologic drugs. All the drugs contributed to a significant improvement of mean total PSSD at t 24; anti-IL17 and anti-IL23 led to a significantly greater reduction at t 24 mean PSSD when compared to other therapies.

Conclusion:
The PSSD, is a new validated instrument useful for capturing psoriasis patient’s quality of life and evaluating treatments efficacy. In our study this score has been useful to put in evidence significant differences between biologic drugs.
Effect of Switching Antiretroviral Treatment Regimen in Patients With Drug-Resistant HIV-1 Infection: Retrospective Observational Cohort Study
Authors: Li Yiping , Wang Qinjian , Liang Shu , Feng Chuanteng , Yang Hong , Yu Hang , Yuan Dan , Yang Shujuan 
Published: June 2022

Background
Evidence on the efficacy of antiretroviral therapy (ART) regimen switches on the mortality of patients with HIV drug resistance (HIVDR) is limited.

Objective
We aim to provide policy guidance for ART regimen selection and evaluate the effectiveness of ART regime switches for people living with HIV and HIV-1 drug resistance.

Methods
This retrospective observational cohort study included 179 people living with HIV and HIV-1 drug resistance from 2011 to 2020. The time that participants switched treatment regimens either to protease inhibitor (PI)–based ART regimens (PIs) or nonnucleoside reverse transcriptase inhibitor (NNRTI)–based ART regimens (NNRTIs) was taken as an observation starting point and followed up every 12 months. The parametric g-formula was used to estimate the 5-year risk of mortality under the situations of (1) natural course, (2) immediate switch to NNRTIs, (3) immediate switch to PIs, and (4) if CD4(+) T cells<200 switched to PIs.

Results
The follow-up time of the 179 patients ranged from 30 to 119 months. The median follow-up time was 90 months. During a follow-up of 15,606 person-months, 27 individuals died in the cohort. The estimated 5-year risk of mortality under natural course, immediate switch to NNRTIs, immediate switch to PIs, and if CD4(+), and switch to PIs if T cells<200 were 11.62% (95% CI 7.82-17.11), 31.88% (95% CI 20.79-44.94), 2.87% (95% CI 0.32-7.07), and 5.30% (95% CI 2.07-10.21), respectively. The risk ratios (RRs) of immediate switch to NNRTIs, immediate switch to PIs, and switch to PIs if CD4(+) T cells<200, compared with natural course mortality rate, were 2.74 (95% CI 2.01-3.47), 0.25 (95% CI: 0.04-0.54), and 0.46 (95% CI 0.22-0.71), respectively. The risk differences were 20.26% (95% CI 10.96-28.61), –8.76% (95% CI –13.34 to –5.09) and –6.32% (95% CI –9.75 to –3.11), respectively.

Conclusions
Our study found that a PI-based ART regimen was beneficial for reducing mortality in people living with HIV and HIV-1 drug resistance. More effort should be given to find HIV-1 drug resistance earlier to ensure a timely adjustment to PI-based ART, thereby maximizing the benefit of early switch treatment for people living with HIV and HIV-1 drug resistance.
THE MODEL OF FREE SPREADING A FLOW RAPID BEHIND A RECTANGULAR PIPE
Authors: Burtseva Olga , Kohanenko Viktor , Evtushenko Sergey , Alexandrova Maria 
Published: June 2022

The article considers the free spreading of a turbulent stationary two-dimensional open potential water flow into a wide diverting riverbed behind a non-pressure pipe of a rectangular section. A system of nonlinear partial differential equations of motion has been adopted as the mathematical model of the flow in the physical plane. When moving to the plane of the velocity hodograph, the nonlinear system of equations is transformed into a linear system with respect to partial derivatives. Using the obtained system of equations, various problems along the flow of two-dimensional water streams have been solved analytically. The paper determines the flow kinetics parameter t and the angle q characterizing the direction of the local flow velocity vector at the intersection points of an arbitrary equipotential and an arbitrary current line. The X, Y coordinates of these points are found. The peculiarities of changing the angle θ during the transition of the vertical front of the XD are taken into account.
Article proposes a module for the transition from a two-dimensional water flow model to a one-dimensional one. This module is necessary for using the laws of flow resistance and taking into account the resistance forces.
The model proposed in this paper is a development of analytical methods for calculating potential flows with previously unknown boundaries and before the flow expands. It allows determining the entire range of geometric and kinematic parameters of the flow with an error not exceeding 10%.
The adequacy of the model for all flow parameters improves the accuracy of previously existing methods. This allows the designers of road culverts to increase its reliability.
PEMBANGUNAN HUKUM NASIONAL YANG RELIGIUS: KONSEPSI DAN TANTANGAN DALAM NEGARA BERDASARKAN PANCASILA
Authors: Manan Bagir , Abdurahman Ali , Susanto Mei 
Published: June 2022

ABSTRAK
Artikel ini menganalis pembangunan hukum nasional religius yang kerap kali dipersoalkan dan menimbulkan konflik serta ketegangan dalam tatanan kehidupan masyarakat Indonesia. Hasil analisis menyimpulkan bahwa pembangunan hukum nasional yang religius di Indonesia adalah sebuah kewajaran dan keniscayaan, karena hukum yang baik harus didasarkan pada nilai-nilai, kenyataan, dan harapan masyarakat. Dengan Pancasila sebagai philosophische grondslag negara, maka dasar Ketuhanan Yang Maha Esa menjadi acuan dalam pembangunan hukum nasional yang religius, baik dalam pembentukan hukum, pelayanan hukum maupun penegakan hukum. Namun demikian, penting untuk memperhatikan kemajemukan dan sensivitas dari asas dan kaidah keagamaan, sehingga diperlukan kehati-hatian, sikap saling menghormati, dan prinsip demokrasi dalam pembangunan hukum nasional yang religius. Selain itu, pembangunan hukum nasional yang religius kerap mendapat tantangan, yang dapat dilihat secara umum dari pembentukan hukum yang rendah kuantitas maupun kualitasnya, serta penegakan dan pelayanan hukum yang koruptif dan mengabaikan prinsip etis/moral sebagai nilai religius. Karena itu, diperlukan kesadaran etis dalam pembangunan hukum nasional yang religius, serta mengarahkannya dalam rangka mencapai Keadilan Sosial bagi seluruh rakyat Indonesia.
Kata kunci: agama; nilai religius; pembangunan hukum.

ABSTRACT
This article analyzes national religious law development, which is often questioned and causes conflict and tension in the Indonesian public order. The article conclude that Indonesia's national religious law development is ordinary and necessary because good law must be based on the community's values, reality, and expectations. With Pancasila as the philosophical foundation of the state, the basis of the Belief in the one and only God becomes a reference in the development of national religious law, both in the forming of law, legal services, and law enforcement. However, it is crucial to attend to the diversity and sensitivity of religious principles and norms so that caution, mutual respect, and democratic principles are needed to develop national religious law. Also, national religious law development often faces challenges, which can be seen in general from the making of laws that are low in quantity and quality and the enforcement and service of law that is corrupt and ignores ethical/moral principles as religious values. Therefore, ethical awareness is needed to develop national religious law and direct it to achieve Social Justice for all Indonesian people.
Keywords: legal development; religion; religious value.
MEREK TIGA DIMENSI DALAM HUKUM MEREK INDONESIA
Authors: Wijayanti Ana Wahyu , Wauran Indirani 
Published: June 2022

ABSTRAK
Indonesia telah mengakui dan melindungi merek non-tradisional khususnya merek tiga dimensi (3D) sebagaimana tertuang dalam Undang-Undang Nomor 20 Tahun 2016 Tentang Merek dan Indikasi Geografis. Namun demikian Undang-Undang tersebut belum mengatur merek 3D dengan jelas, baik itu terkait dengan persyaratan tanda 3D yang dapat didaftarkan sebagai merek maupun terkait dengan penentuan daya pembeda pada Merek 3D. Berangkat dari permasalahan ini Penulis hendak melakukan penelitian hukum dengan menggunakan pendekatan perbandingan. Penelitian ini mencoba mempelajari konsep merek 3D dalam hukum merek Amerika Serikat dan Uni Eropa guna memperoleh pemahaman tentang merek 3D yang belum diatur secara komprehensif dalam hukum merek Indonesia. Berdasarkan hasil penelitian mengenai konsep merek 3D di Amerika Serikat dan Uni Eropa terdapat ketentuan khusus berkaitan dengan persyaratan tanda 3D yang dapat didaftarkan sebagai merek dan terdapat metode penentuan daya pembeda pada merek 3D yang cukup berbeda dari metode penentuan daya pembeda yang biasa digunakan pada merek tradisional. Artikel ini memberikan argumen bahwa Indonesia dapat menggunakan konsep merek 3D di negara Amerika Serikat dan Uni Eropa untuk memperkaya konsep merek 3D.
Kata kunci: merek; merek non-tradisional; merek tiga dimensi.

ABSTRACT
Indonesia has recognized and protected non-traditional trademark, in particular three-dimensional (3D) trademark, as stated in Law Number 20 of 2016 concerning Trademarks and Geographical Indications. However, the Law does not regulate 3D trademarks, either concerning the requirements for 3D trademarks or to determine the distinguish power of 3D trademarks. Departing from this problem, the author wants to conduct legal research using a comparative approach. This research tries to study the concept of 3D trademarks in the trademark law of the United States and the European Union to gain an understanding of the 3D trademark that has not been comprehensively regulated in Indonesian trademark law. Based on the results of the author's research regarding the 3D trademark concept in the United States and the European Union, there are special provisions relating to the requirements for a 3D trademark that can be registered as a trademark. There is a method of determining the distinguishing power of a 3D trademark. This method is different from the method to determine the distinguish power commonly used in traditional brands. This article argues that Indonesia can use the 3D trademark concept in the United States and the European Union to enrich the 3D trademark concept.
Keywords: 3D trademark; non traditional trademark; trademark.
PENGEMBANGAN MUATAN MATERI KONSTITUSI TENTANG HAK ASASI MANUSIA: PERBANDINGAN INDONESIA, SINGAPURA, DAN REPUBLIK RAKYAT CINA
Authors: Ridzki Kharisma Muhammad 
Published: June 2022

ABSTRAKMuatan materi konstisusi secara luas mengatur beberapa hal yang paling fundamental demi kehidupan berbangsa dan bernegara. Tidak semua hal dapat dimasukkan dalam muatan materi konstitusi, ada hal yang pokok tapi tidak penting, pun sebaliknya. Hak asasi manusia (human right) menjadi salah satu muatan materi penting dan pokok dalam konstitusi yang dimiliki oleh suatu negara. Namun, dewasa ini telah terjadi perkembangan HAM yang begitu pesat di setiap negara. Meskipun hakikat dasar HAM itu bersifat kodrati, universalitas dan abadi, namun pada kenyataannya di setiap negara memberikan klasifikasi HAM yang berbeda-beda, tergantung pada kondisi dan persoalan dalam negara yang bersangkutan. Dalam tulisan ini akan dikaji mengenai bagaimana urgensi muatan materi HAM dalam konstitusi negara hukum yang demokratis. Kemudian akan membahas bagaimana perbedaan dan persamaan mengenai pengembangan muatan materi konstitusi tentang hak asasi manusia dalam konstitusi Indonesia, Singapura dan Republik Rakyat Cina?Kata kunci: HAM; materi konstitusi; perbandingan.
ABSTRACTThe content of constitution material broadly regulates some of the most fundamental things for the life of the nation and state. Not all things can be included in the material content of the Constitution, because there are basic things but not important, however. Human right became one of the important materials and the principal in the Constitution owned by a country. Nowadays, however, there has been a rapid development of human rights in every country. Although the basic nature of human rights is natural, universal and eternal, in reality each country provides a different classification of human rights, depending on the conditions and problems in the country concerned. In this paper, we will examine the urgency of the content of human rights material in the constitution of a democratic rule of law. Then we will discuss the differences and similarities regarding the development of constitutional material content on human rights in the constitutions of Indonesia, Singapore and the People's Republic of China?Keywords: human rights; material constitution; comparative.
PENERAPAN CLASS ACTION DI INDONESIA STUDI KASUS PUTUSAN NOMOR 1794 K/Pdt/2004
Authors: Parlina Nurasti 
Published: June 2022

Abstrak
Gugatan perwakilan atau class action dalam penyelesaian sengketa hukum lingkungan di Indonesia mengalami tren positif pasca adanya PERMA Nomor 1 Tahun 2002 tentang Acara Gugatan Perwakilan Kelompok yang kemudian disusul dengan adanya gugatan perwakilan sebagaimana Putusan Nomor 1794 K/Pdt/2004 yang merupakan preseden dalam hal penerapan gugatan perwakilan di Indonesia. Tulisan ini hendak mengkaji bagaimana penerapan gugatan perwakilan yang diajukan oleh korban longsor Mandalawangi. Metode penelitian ini menggunakan yuridis normatif dengan pendekatan studi kasus. Penulis kemudian menyimpulkan bahwa penerapan gugatan perwakilan dalam kasus ini sudah sesuai dengan peraturan yang ada dan telah diterapkan oleh Hakim dengan sangat baik. Kemudian salah satu manfaat dari adanya gugatan perwakilan dalam perkara ini adalah adanya kepastian atas ganti rugi yang akan didapatkan oleh korban longsor Mandalawangi. Hal ini menandakan bahwa gugatan perwakilan di Indonesia jika diterapkan secara benar akan memudahkan masyarakat yang mencari keadilan.
Kata kunci: Ganti rugi; Gugatan Perwakilan; Lingkungan Hidup.

Abstract
Class action in the settlement of environmental legal disputes in Indonesia has experienced a positive trend after the existence of PERMA No.1 of 2002 about class action procedure which was then followed by a representative lawsuit in Decision Number 1794 K / Pdt / 2004 which is a precedent in the application of a representative lawsuit in Indonesia. This paper is reviewing the application of the representative lawsuit filed by the Mandalawangi landslide victims. The research method uses normative juridical with a case study approach. The author then concluded that the application of the representative suit in this case was in accordance with the existing regulations and had been implemented by the Judge very well. Then one of the benefits of having a representative suit in this case is the certainty of compensation that will be collected by the victims of the Mandalawangi landslide. This indicates that the representative suit in Indonesia, if properly implemented, will make it easier for people seeking justice.
Keywords: Compensation; Environment; Representative Lawsuit.
PENGENDALIAN KEBAKARAN HUTAN MELALUI PENGUATAN PERAN POLISI KEHUTANAN UNTUK MEWUJUDKAN SUSTAINABLE DEVELOPMENT GOALS
Authors: Muzaki Ahmad , Pratiwi Reza , Az Zahro Salsabila Rahma 
Published: June 2022

ABSTRAK
Indonesia dikenal sebagai salah satu paru-paru dunia dikarenakan lebih dari 50% wilayah daratannya berupa hutan. Namun dalam implementasinya, pengelolaan hutan belum dilakukan secara optimal, dibuktikan dengan masih adanya kasus kebakaran hutan, yang mempunyai implikasi terhadap kesehatan masyarakat dan lingkungan. Hal ini bertentangan dengan Pasal 28H ayat (1) Undang-Undang Dasar Negara Republik Indonesia Tahun 1945 yang menjelaskan bahwa setiap warga negara berhak mendapatkan lingkungan hidup yang baik dan sehat. Penelitian ini menggunakan metode yuridis normatif. Pendekatan yang digunakan yaitu perundang-undangan, konseptual dan studi kasus. Jenis data yang digunakan yaitu data kualitatif yang menggunakan sumber data sekunder. Metode pengumpulan data yang digunakan adalah studi kepustakaan. Dalam penelitian ini, penulis menemukan bahwa peran Polisi Kehutanan belum maksimal dalam pengendalian kebakaran hutan. Oleh karena itu, diperlukan penguatan peran Polisi Kehutanan untuk melakukan pengendalian kebakaran hutan. Dengan upaya tersebut, diharapkan dapat meminimalisir kasus kebakaran hutan serta dampak yang ditimbulkannya agar selaras dengan Sustainable Development Goals.
Kata kunci: Kebakaran Hutan; Polisi Kehutanan; Sustainable Development Goals

ABSTRACT
Indonesia is known as one of the lungs of the world because more than 50% of its land area is forest. However, in its implementation, forest management has not been carried out optimally, as evidenced by cases of forest fires, which have implications for public health and the environment. This is contrary to Article 28H paragraph (1) of the 1945 Constitution of the Republic of Indonesia which explains that every citizen has the right to a good and healthy environment. This study uses a normative juridical method. The approach is legislation, conceptual and case studies. The type of data is qualitative data using secondary data sources. The data collection method is literature study. In this study, the authors found that the role of the forest police had not been maximized in controlling forest fires. Therefore, it is necessary to strengthen the role of the forest police in controlling forest fires. With these efforts, it is expected to minimize cases of forest fires and their impacts so that they are in line with the Sustainable Development Goals.
Keywords: Forest Fire; Forestry Police; Sustainable Development Goals
Magnetic prospecting and rock magnetic study of soils and archaeological objects on the Late Roman time sites near Komariv in Middle Transnistria
Authors: Bondar K.M. , Petrauskas O.V. , Khomenko R.V. , Popov S.A. 
Published: June 2022

The paper presents the outcome of the magnetic survey at the settlement and cemetery of the production center of the 3rd—5th centuries, Komariv (Khotyn district, Chernivtsi region), which is located on the right bank of the Dniester. The settlement has about seventy anomalies that may have an archaeological origin. The archaeological study of individual anomalies has confirmed, as expected, the reliability of geophysical interpretation of thermal structures (kilns, furnaces) and living and production dugouts deepened into the loess parent rock.
Magnetic imaging at the cemetery showed about eight tens of local anomalies with an intensity of 1.5—4.5 nT. Excavations of some anomalies revealed the Early Iron Age dugout and two Late Roman graves. However, the other two excavated graves did not cause disturbance of magnetic field.
Laboratory measurements of magnetic susceptibility, natural remanent magnetization and other concentration-dependent and grain-size-dependent parameters of the ferromagnetic phase, as well as magnetic mineralogy examination have shown that grave pits, which appeared on a magnetic map, are refilled almost exclusively with humus soil material. Magnetic modeling proved graves can create measured anomalies if their magnetization is equal to the magnetization of the humus horizon of the soil. Thus, these grave pits were left open and gradually refilled with moist soil material. In particular, conditions have been created for the formation of detrital remanence.
When restoring the spatial structure of Komariv sites based on magnetic prospecting results, it is necessary to take into account probable multilayered structure of monuments, geomorphological features of the area, which can be misinterpreted as archeological objects, and the fact that important examples of ancient architecture constructed of non-magnetic materials and grave pits refilled immediately after digging will be absent on magnetic maps.