bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of flood susceptibility areas using Optimized BP neural network models over the Tumen River Basin, China
Authors: Quan He Chun , Jin Ri , Jin Aifen , Jin Guangri , Zhu Weihong , Lin Zhehao 
Published: April 2022

Abstract
Floods caused by rainstorms occur almost every year in Tumen River Basin. The floods caused severe damage to local residents, property and the ecological environment. For reducing the damage of floods, it is necessary to produce the flood susceptibility map. For mapping the flood prone areas, four algorithms such as genetic algorithm (GA), particle swarm optimization (PSO), artificial fish swarm algorithm (AFSA) and artificial bee colony algorithm (ABC) were used to optimize back propagation (BP) neural network respectively. The accuracy of the model was evaluated by Receiver Operating characteristic (ROC), root mean square error(RMSE) and mean absolute error (MAE). A total number of 222 flooded and un-flooded locations were identified. 155 locations of which were randomly selected to training the model, and the remaining 67 locations were used to validate the model. A total of thirteen flood conditioning factors，including altitude, slope, aspect, curvature, Topographic Wetness Index (TWI), Stream Power Index (SPI), Sediment Transport Index (STI), distance to river, landuse, rainfall, lithology, runoff coefficient and soil type were used in the proposed models. The area under the curve (AUC) obtained from ROC indicated that AFSA-BP showed a high accuracy (99.91%), and ABC-BP had the lowest prediction accuracy (97.28%). According to the generated flood susceptibility map, about 13% of Tumen River Basin is under very high flood susceptibility. The distance to river, rainfall, altitude and land use have the greatest impact on flood susceptibility. The results showed that the BP model optimized by the four algorithms is an effective and reliable tool for mapping the flood susceptibility. The flood susceptibility map can be used in flood prevention strategies.
Low Alveolar Macrophage Function, Low IL-6, and High CD4 Cell Count Interaction in BALF of Severe Pneumonia Patients with Extubation Success
Authors: Singh Gurmeet , Rumende Cleopas Martin , Sharma Surendra K , Rengganis Iris , Amin Zulkifli , Loho Tonny , Pranggono Emmy Hermiyanti , Harimurti Kuntjoro , Wibowo Heri , Fauzi Nova Bornida , Masse Sudirman Fakhruddin 
Published: April 2022

Abstract
Background: Understanding the bronchoalveolar-lavage fluid immunopathology biomarker interactions can help clinicians decipher the pathophysiology of severe pneumonia and get better management for early extubation.Objectives: The objectives were to assess bronchoalveolar lavage fluid biomarker interactions of severely affected lung and their association in determining the early extubation success.Methods: In this cross-sectional study, we consecutively evaluated 137 severe pneumonia patients. Patients who fulfilled inclusion criteria will undergo early bronchoscopy. The BALF was collected from the right and left lungs. Two Respirologist and Critical Illness consultants, plus one internist, determined the location for severely affected lung. Biomarker interactions in severely affected lung were analyzed. The primary outcome was the 19-days extubation.Results: Forty patients underwent bronchoscopy for BALF collection. The right lung was the predominant severely affected lung (28 patients). Eight patients survived and were successfully extubated within 19 days. There were significantly higher absolute CD4+ BALF cell counts (95% Confidence Interval = 9,24 – 49,50, p = 0,003) in the left lung and higher absolute CD4+ BALF cell counts (95% Confidence Interval = 9,00 – 29,75, p = 0,010) in the patients with extubation success and survived. Among all the patients with extubation success within 19 days, eight patients (100%) displayed the tendency of high CD4 levels (cutoff points median 16 cells/μL), low expression of alveolar macrophage function (cutoff points by ROC 756.5 MFI CD169), and low expression of IL-6 (cutoff points by ROC 369 pg/mg protein).Conclusion: In severely affected lung of severe pneumonia patients with early extubation success and survived, we found biomarker interactions marked by low alveolar macrophage function, low IL-6 levels, and high CD4 levels. Trial Registration: The study was registered at UMIN Clinical Trials Registry (UMIN-CTR) (registration number UMIN000046236), accessible at: https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000049197
Reduced DIO3OS expression in hepatocellular carcinoma predicts poor prognosis and is associated with tumor immunity
Authors: Wang Yunhan , Sun Ping , Hao Xinping , Cao Daihong , Liu Jiangyue , Zhang Daijian 
Published: April 2022

Abstract
Hepatocellular carcinoma(HCC) has become one of the most shared cancers in the whole world because of its high morbidity, poor survival rate and low recovery rate. Especially in China, HCC has been regarded as one of the most malignant cancers. With the development of tumor exploration and treatment over the years, it has been found that lncRNA plays a direct or indirect regulatory role in the process of tumorigenesis and cancer development, which brought a new direction for early diagnosis and therapy. Previous studies had investigated that DIO3OS played a promoting role in the occurrence and development of thyroid carcinoma and uterine corpus endometrial carcinoma. However, research focusing on the role of DIO3OS in HCC is still uncleared. Our work found that there was a significant negative correlation between low DIO3OS levels and HCC. In addition, there was also a correlation between immune cells and their surface markers and DIO3OS expression in HCC. Our findings demonstrated that DIO3OS may be a potential prognostic biomarker involved in the process of HCC by regulating immune cell infiltration.
The mechanism of CTRP6 in promoting cancer in digestive system tumors
Authors: Zhang Aimin , Kong Mowei , Zhang Xiuyun 
Published: April 2022

Abstract
Tumors of the digestive system have always received attention, and their occurrence and development are regulated by various mechanisms such as inflammation and immunity, glucose and lipid metabolism, and tumor angiogenesis. Complement Clq/TNF-related protein 6 (CTRP6) is a member of the CTRP family. It is widely expressed in various tissues and cells and plays a biological role in many aspects such as glucose and lipid metabolism and inflammation. Function. Recent studies have revealed the tumor-promoting effect of CTRP6 in gastric cancer, liver cancer, colorectal cancer and other gastrointestinal tumors, but there is no systematic discussion on the tumor-promoting mechanism of CTRP6. This article will review the role of CTRP6 in tumors of the digestive system and its possible mechanisms.
Do Pregnant Women Perceive Being Counseled About Nutrition by Healthcare Providers?
Authors: Jackson Hayn , Stickler Erin , Tan Xiyan , Trilk Jennifer 
Published: April 2022

Abstract
BACKGROUND: The American Academy of Nutrition and Dietetics identifies a balanced diet and appropriate weight gain as two important components of a healthy pregnancy. The aim of this study was to examine whether or not a population of pregnant women perceived being counseled by their provider about nutrition during their pregnancy. This study expands on the current literature by examining postpartum women’s perception of counseling throughout their pregnancy.METHODS: We conducted an anonymous, voluntary survey using online software for women who had recently given birth and were less than two-weeks postpartum. Each participant completed a 27-item survey using REDCap (Research Electronic Data Capture) software via email. Discrete variables were analyzed using Chi-square or Fisher’s exact test. Analyses were carried out using R statistical software. Differences were considered statistically significant at p<0.05.RESULTS: Of 201 postpartum women surveyed, 100 (49.8%) perceived receiving nutrition counseling during pregnancy and 101 (50.2%) did not recall receiving nutrition counseling. Of the 101 women who did not perceive receiving counseling, 56% of women reported that they would have liked to receive counseling during pregnancy. There was a statistically significant difference in women reporting receiving preconception nutrition counseling across age, race, education and income level. 41% of women reported feeling “very dissatisfied” about their provider’s advice and 36% reported feeling “satisfied.”CONCLUSION: These findings suggest that the majority of women may not be satisfied with nutritional counseling during pregnancy; although this satisfaction may differ among demographics or socioeconomic status. Additional research is needed to determine perceptions of providers’ counseling and potential needs in providers’ knowledge, skills and attitudes toward nutrition counseling, particularly across different demographic groups and social determinants of health.
Identification of (Z)-9-heptacosene and (3Z,6Z,9Z)-tricosatriene as new sex pheromone components of Korean Conogethes punctiferalis (Lepidoptera: Crambidae) population and field attraction testing
Authors: Nam Il , Park Ji-Hong , Lee Jae-Woo , Lee Dong Ha , Jung Wanjo , Lee Wook , Park Il-Kwon 
Published: April 2022

Abstract
Recently, reduced attractiveness of Conogethes punctiferalis adult males to sex pheromone, (E)-10-hexadecenal and (Z)-10-hexadecenal, has been reported. To identify the other essential components of sex pheromone, male and female body extracts were analyzed. Two hydrocarbon components, (Z)-9-heptacosene (Z9-27:HC) and (3Z,6Z,9Z)-tricosatriene (Z3,Z6,Z9-23:HC), were identified from only female body extract. There was a significant difference in the electroantennogram (EAG) response of male antennae to Z3,Z6,Z9-23:HC and Z9-27:HC at all test concentrations compared to response to the hexane control. In field attraction testing, the addition of Z9-27:HC and Z3,Z6,Z9-23:HC to binary aldehyde pheromones significantly increased trap catches of C. punctiferalis male adults. Based on the female and male body extract analysis and field attraction test, Z-9-27:HC and Z3,Z6,Z9-23:HC were determined to be other essential sex pheromone components of the Korean C. punctiferalis population.
Temporal–spatial decomposition of city-scale changes in sectoral CO2 emissions in southeast China
Authors: HUANG Yimin , Wang Yuan , He Yanmin , Zhu Lin , Lai Wen-ting 
Published: April 2022

Abstract
Carbon emissions are typically analyzed on a national scale. However, to achieve regional carbon reduction targets, research should be carried out at sub-provincial and municipal scales, and the driving forces of sectoral CO2 emissions should be analyzed from a more disaggregated perspective. In this study, we apply temporal logarithmic mean Divisia index (LMDI) decomposition for exploring the factors influencing changes in city-scale energy-related CO2 emissions across industry, transportation, and household sectors in Fujian Province during 2000–2017. Moreover, the spatial LMDI model is employed to investigate spatial discrepancies in the driving forces of CO2 emissions among nine prefecture-level cities in 2000, 2005, 2010, 2015, and 2017. The results suggest that the magnitude of energy-related CO2 emission changes in the industry sector was much higher than that in the transportation and household sectors in Fujian Province. Moreover, the income effect was the dominant factor leading to increased CO2 emissions in the three sectors of each city. Conversely, the energy intensity effect was the primary factor responsible for the mitigation of CO2 emissions in each city during 2000–2017, except in the transportation sector. The urbanization effect was another crucial factor contributing to increased CO2 emissions in all sectors, whose contribution was greater in coastal cities than in non-coastal ones. Additionally, the energy intensity effect was the main factor responsible for the discrepancy in CO2 emissions among cities. The findings of this study can be used to propose targeted policy recommendations for low-carbon development in Fujian Province.
Magnesium perchlorate added crosslinked starch: a step towards possibility of commercial Polymer-In-Salt-Electrolytes (PISE)
Authors: YADAV DIPTI , Srivast Neelam 
Published: April 2022

Abstract
Single and fast ion transport in all-solid-state-flexible-electrolyte systems is desired for energy devices. The commercially used polymer electrolytes consist of liquid component to achieve the requiredelectrochemical properties and they also suffer from slow and poor cation transfer.Thepolymer-in-salt-electrolytes (PISEs) are supposed to lead to single and fast ion transport, unfortunately polymer hosts and salts,which can lead to successful synthesisof PISE with targeted minimum conductivity (10-4 S/cm) with suitable morphology is still to be identified.All efforts resulted either in poor electrochemical properties and/or poor morphology because of recrystallization of salt. Here novel PISEsare discussedwhich have high conductivity (0.1 S/cm) and small ion relaxation time (10 μ sec) with wide electrochemical-stability-window (> 2.5V). Since in PISEs the ion transport is decoupled from polymer segmental motion and it takes place through ion cluster, hence it is of immense importance to understand how the host matrix affects electrochemical properties of PISEs, hence three different starches (potato starch, corn starch and arrowroot starch) have been selected keeping all other constituent chemical and synthesis process same. Signature effects of host starches are observed and discussed.
Truncated tau disrupts autophagy and lysosomal biogenesis
Authors: Dakkak Dina , Pollack Saskia , Guo Tong , Chennell George , Suaga Patricia Gomez , Noble Wendy , Hanger Diane P 
Published: April 2022

Abstract
The autophagy-lysosomal pathway plays a critical role in the clearance of tau protein aggregates that deposit in the brain in tauopathies, including Alzheimer’s disease and defects in this system are associated with disease pathogenesis. Here, we report that expression of Tau35, a tauopathy-associated carboxy-terminal fragment of tau, reduces beclin-1 and microtubule-associated protein 1A/1B-light chain 3, indicating that Tau35 disrupts autophagy in cells. We demonstrate that Tau35 reduces autophagic flux by blocking activation of 5' AMP-activated protein kinase and activating mammalian target of rapamycin complex 1 (mTORC1), as seen by increased phosphorylation of S6 ribosomal protein and a reduction in phosphorylated raptor. Tau35 also induces neutral lipid accumulation in cells, indicating a block of autophagic clearance and a deficit in lysosomal degradative capacity. In support of this view, reductions in lysosomal-associated membrane protein 2 and cathepsin D in cells expressing Tau35 are accompanied by its increased colocalisation with lysosomes. These deleterious effects of Tau35 on autophagy are not apparent with full-length tau, indicating that sequences in the amino-terminal half of tau may be involved in the regulation of mTORC1 and autophagic activity. Notably, upon induction of autophagy by Torin 1, both Tau35 and full-length tau inhibited nuclear translocation of transcription factor EB (TFEB), a key regulator of lysosomal biogenesis. These findings implicate autophagic and lysosomal dysfunction as key pathological mechanisms through which abnormal tau could lead to the development and progression of tauopathy.
Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1
Authors: Pluta Radoslaw , Aragon Eric , Prescott Nicholas , Baginski Blazej , Ruiz Lidia , Flood Julia , Martin-Malpartida Pau , Massague Joan , David Yael , Macías María 
Published: April 2022

Abstract
Nucleosomes are barriers for the binding of most transcription factors, but pioneer factors (PFs) do bind and facilitate subsequent interactions of other proteins during transcription activation. FoxH1 is a maternal PF essential during embryonic development that interacts with specific GK-forkhead targets. How FoxH1 binds DNA targets has remained elusive for decades until now. We have determined high-resolution structures of human, frog and fish proteins bound to four DNAs. We found that the FoxH1 DNA-binding domain is almost twice the size of other FOX proteins, allowing for a highly specific binding to both minor and major grooves. Consistent with its PF activity, we also quantified that the affinity for DNA is even higher for native mononucleosomes than for linear DNA. Our structures illustrate how binding to distinct GK sites allows FoxH1 to avoid cross-regulation by other FOX proteins that also operate during the maternal-zygotic transition and select canonical TT-forkhead sites.
RIP1 inhibition prevents mechanical stress-induced TMJ OA by regulating apoptosis and late-stage necroptosis of chondrocytes
Authors: Zhou Yiwen , Lin Shuang , Huang Ziwei , Zhang Caixia , Wang Huijuan , Li Baochao , Li Huang 
Published: April 2022

Abstract
Temporomandibular joint osteoarthritis (TMJ OA) is a common degenerative joint disease that has multiple causes. The abnormal stress distribution is known to be an important trigger of TMJ OA. In order to clarify the mechanism of pathological changes in mandibular cartilage under compressive mechanical stress and the function of RIP1 inhibition through Lenti-virus in mechanical stress-induced TMJ OA, we used a compressive mechanical force-induced-TMJ OA rat model and Lenti-virus targeting RIP1 to perform this study. The results identified the characteristics of the spatio-temporal changes in mechanical stress-induced TMJ OA. Under mechanical force, inflammation and apoptosis, which occur in the whole layer of mandibular cartilage, appear on 4th day and persist till 7th day. Necroptosis arises in the late stage of mechanical force and is mainly located in the transition layer. RIP1 plays an essential role in the destruction of mandibular cartilage under mechanical force. RIP1 inhibition through Lenti-virus could protect mechanical stress-induced mandibular cartilage thinning by inhibiting persisted apoptosis and late-stage necroptosis in the transition layer.
A combination of Granulocyte-macrophage colony-stimulating factor with the R2 regimen in elderly high-risk B cell lymphoma maintenance therapy improves survival by modulating natural killer cells
Authors: Sun Shunrong , fulati Wulipan , Shen Lin , Wu Min , Huang Zilan , Qian Wensi , Chen Pingping , Hu Yingwei , Chen Mingyue , Xu Yu , Zhang Hongdi , Ma Jiexian , Xie Yanhui 
Published: April 2022

Abstract
Background
The clinical outcome of B-cell lymphoma has improved dramatically due to hematopoietic stem cell transplantation (HSCT) and biological agents. However, treatment of high-risk B cell lymphoma in the elderly remains a challenge because of their ineligibility for HSCT, high mortality and relapse rates. Maintenance therapy to improve the prognosis of B cell lymphoma in the elderly might be feasible.
Methods
We analyzed the efficacy of a combination of human recombinant granulocyte-macrophage colony-stimulating factor (rhGM-CSF) with the R2 regimen in maintenance therapy in high-risk B cell lymphoma in the elderly of our center. A total of 83 elderly patients, who were ineligible for auto-HSCT and had a response after 6 cycles of induction therapy above a partial response, were divided into two groups: observation (n = 44) and R2 + GM-CSF (n = 39) by enrollment time.
Results
The clinical data, survival outcome, and the number of peripheral blood mononuclear cells were analyzed and compared. The numbers of lymphocytes (1.19 × 109/L vs. 1.03 × 109/L, P = 0.0062) and leukocyte (6.46 × 109/L vs. 4.85×109/L, P = 0.0048) increased after receipt of maintenance therapy, particularly the number of natural killer cells (0.131 × 109/L vs. 0.061 × 109/L, P = 0.0244). Patients receiving R2 + GM-CSF for maintenance had longer-term remission (duration of response (DOR): 18.9 months vs. 11.3 months, P = 0.001), and longer-term progression free survival (PFS) (not reached (NR) vs. 31.7 months, P = 0.037), and overall survival (OS) (NR vs. NR, P = 0.015). The new R2 regimen was safe and well tolerated. The elderly, high-risk, and high tumor burden seemed to have tendency to be independent prognostic factors for a better PFS (P = 0.060, 0.012, 0.005).
Conclusions
The new R2 regimen prolonged progression-free survival and overall survival among elderly patients with high-risk B cell lymphoma, appeared to lead to improve response without compromising its tolerability profile in elderly patients who are ineligible to receive HSCT. The number of patients in this trial was limited and the conclusions should be verified in larger, prospective, multicenter studies.
Retrospectively registered:
The ethical committee of Huadong Hospital (approval number: 2021K186).
Expression profiles of differentially expressed circular RNAs and circRNA/miRNA/mRNA network in SH-SY5Y cells infected with Coxsackievirus B5
Authors: Li Jing , Yang Heng , Shi Huaran , Yang Fan , Ou Xia , Zhang Jihong , Chen Wei 
Published: April 2022

Abstract
Coxsackievirus B5 (CV-B5) is the causative agent of hand, foot and mouth disease (HFMD) that can cause neurological complications and fatalities. Circular RNA (circRNA) has been shown to play an important role in regulating pathogenic process. However, their functions of circRNA in response to CV-B5 infection remain unclear. In our research, RNA-seq was employed to analyze the expression profiles of circRNAs in SH-SY5Y cells with or without CV-B5 infection. Out of 5,665 circRNAs identified to be expressed in SH-SY5Y cells, 163 circRNAs were found to be differentially expressed significantly. Moreover, Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses showed that the differentially expressed circRNAs were mainly involved in ubiquitin-mediated proteolysis and signaling pathways during CV-B5 infection. Additionally, RT-qPCR was used to validate the RNA-seq data and a circRNA/miRNA/mRNA interaction network was constructed based on two circRNAs. Two circRNAs, such as: hsa_circ_0008378 and novel_circ_0014617, were associated with the regulation of innate immune response in host cells. Additionally, we confirmed the two circRANs up-regulated the key factors in the IFN signaling pathway, hampering viral replication. Our data provide a new perspective that facilitates further understanding on the virus-host mechanism.
Molecular functional analyses of larval adhesion in a highly fouling invasive model ascidian
Authors: Cheng Jiawei , Li Shiguo , Li Xi , Fu Ruiying , Huang Xuena , Zhan Aibin 
Published: April 2022

Abstract
Successful papillary adhesion is the first essential step for serious ascidian biofouling in marine ecosystems; however, the mechanisms of papillary adhesion have not been fully elucidated. Here, we employed micro-transcriptome sequencing to assess the differentially expressed genes (DEGs) between papillae and remaining body in the larvae of the highly fouling invasive model ascidian Ciona robusta. Enrichment results for DEGs showed that papillae were adhesive structures with the combined functions of substrate recognition, environmental perception, and adhesive protein synthesis and secretion. Two candidate ascidian papilla adhesive proteins (APAPs), APAP-1 and APAP-2, were identified, expressed, and purified in vitro. Surface coating tests showed that APAP-1 was a cohesive protein while APAP-2 was an interfacial protein involved in the adhesion between papillae and material surface. Collectively, the obtained DEGs and adhesive proteins provide candidates to deeply understand molecular mechanisms of underwater adhesion and further develop anti-fouling strategies in marine ecosystems.