bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila
Authors: Jarabo Patricia , Barredo Celia G. , de Pablo Carmen , Casas-Tinto Sergio , Martin Francisco A. 
Published: June 2022

AbstractVirtually every single living organism on Earth shows a circadian (i.e. “approximately a day”) internal rhythm that is coordinated with planet rotation (i.e. 24 hours). External cues synchronize the central clock of the organism. Consequences of biological rhythm disruptions have been extensively studied on cancer. Still, mechanisms underlying these alterations, and how they favor tumor development remain largely unknown. Here, we show that glioblastoma-induced neurodegeneration also causes circadian alterations inDrosophila. Preventing neurodegeneration in all neurons by genetic means reestablishes normal biological rhythms. Interestingly, in early stages of tumor development, the central pacemaker lengthens its period, whereas in later stages this is severely disrupted. The re-adjustment of the external light:dark period to longer glioblastoma-induced internal rhythms delays glioblastoma progression and ameliorates associated deleterious effects, even after the tumor onset.
Correlative SIP-FISH-Raman-SEM-NanoSIMS links identity, morphology, biochemistry, and physiology of environmental microbes
Authors: Schaible George A , Kohtz Anthony J , Cliff John , Hatzenpichler Roland 
Published: June 2022

AbstractMicroscopic and spectroscopic techniques are commonly applied to study microbial cells but are typically used on separate samples, resulting in population-level datasets that are integrated across different cells with little spatial resolution. To address this shortcoming, we developed a workflow that correlates several microscopic and spectroscopic techniques to generate an in-depth analysis of individual cells. By combining stable isotope probing (SIP), fluorescence in situ hybridization (FISH), scanning electron microscopy (SEM), confocal Raman microspectroscopy (Raman), and nano-scale secondary ion mass spectrometry (NanoSIMS), we illustrate how individual cells can be thoroughly interrogated to obtain information about their taxonomic identity, structure, physiology, and metabolic activity. Analysis of an artificial microbial community demonstrated that our correlative approach was able to resolve the activity of single cells using heavy water SIP in conjunction with Raman and/or NanoSIMS and establish their taxonomy and morphology using FISH and SEM. This workflow was then applied to a sample of yet uncultured multicellular magnetotactic bacteria (MMB). In addition to establishing their identity and activity, backscatter electron microscopy (BSE), NanoSIMS, and energy-dispersive X-ray spectroscopy (EDS) were employed to characterize the magnetosomes within the cells. By integrating these techniques, we demonstrate a cohesive approach to thoroughly study environmental microbes on a single-cell level.
Microbial community structure is stratified at the millimeter-scale across the soil–water interface
Authors: Cai Yu-Jia , Liu Zi-Ao , Zhang Sha , Liu Hao , Nicol Graeme W , Chen Zheng 
Published: June 2022

Abstract
Soil–water interfaces (SWI) are biogeochemical hotspots characterized by millimeter-scale redox gradients, indicating that parallel changes are also present in microbial community structure and activity. However, soil-based analyses of microbial community structure typically examine bulk samples and seldom consider variation at a scale relevant to changes in environmental conditions. Here we presented a study that aimed to describe millimeter-scale variance in both microbial community structure and physicochemical properties in a lab flooded soil. At this fine-scale resolution, the stratification of biogeochemical properties (e.g., redox potential, nitrate concentration) was consistent with the structure of the active microbial community with clear shifts in the relative abundance of transcriptionally active populations associated with changing redox conditions. Our results demonstrate that spatial scale should be carefully considered when investigating ecological mechanisms that influence soil microbial community structures.
Simulated Laryngeal High-Speed Videos for the Study of Normal and Dysphonic Vocal Fold Vibration
Authors: Aichinger Philipp , Kumar S. Pravin , Lehoux Sarah , Švec Jan G. 
Published: June 2022

Purpose:
Laryngeal high-speed videoendoscopy (LHSV) has been recognized as a highly valuable modality for the scientific investigations of vocal fold (VF) vibrations. In contrast to stroboscopic imaging, LHSV enables visualizing aperiodic VF vibrations. However, the technique is less well established in the clinical care of disordered voices, partly because the properties of aperiodic vibration patterns are not yet described comprehensively. To address this, a computer model for simulation of VF vibration patterns observed in a variety of different phonation types is proposed.

Method:
A previously published kinematic model of mucosal wave phenomena is generalized to be capable of left–right asymmetry and to simulate endoscopic videos instead of only kymograms of VF vibrations at single sagittal positions. The most influential control parameters are the glottal halfwidths, the oscillation frequencies, the amplitudes, and the phase delays.

Results:
The presented videos demonstrate zipper-like vibration, pressed voice, voice onset, constant and time-varying left–right and anterior–posterior phase differences, as well as left–right frequency differences of the VF vibration. Video frames, videokymograms, phonovibrograms, glottal area waveforms, and waveforms of VF contact area relating to electroglottograms are shown, as well as selected kinematic parameters.

Conclusion:
The presented videos demonstrate the ability to produce vibration patterns that are similar to those typically seen in endoscopic videos obtained from vocally healthy and dysphonic speakers.

Supplemental Material:

https://doi.org/10.23641/asha.20151833
Analytical modelling of No‐load magnetic field for equivalent poles of a new type of double‐stator PM poles spherical motor
Authors: Chen Qing , Yang Xiangyu , Cao Jianghua , Zhong Guanming , Zeng Bingsen , Zhao Shiwei , Zeng Guanbao 
Published: June 2022

AbstractA double‐stator swing rotating permanent magnet spherical motor (SR‐PMSM) is designed, which can realize rotation, swing and spiral motion, and is used in the multi‐degree‐of‐freedom motion fields of industrial robot joints, torque gyroscopes, panoramic photography tables and so on. The inner surface of the rotor of the motor is attached with cylindrical PM poles, and the outer surface is attached with trapezoidal PM poles. Cylindrical and trapezoidal PM poles are simple to manufacture, but the magnetic field model of a spherical motor with two kinds of PM poles is complex. Therefore, a magnetic field modelling method combining the geometric equivalence principle and analytical method is proposed. Using the method of shape approximation, according to the principle of equivalence, the key parameters of cylindrical PM poles and trapezoidal PM poles are replaced by the parameters of approximate dihedral PM poles in a spherical coordinate. Select the most suitable dihedral PM poles, establish the analytical model of the magnetic field in the spherical coordinate system and verify the analytical results by FEM method. A SR‐PMSM motor with 6/4 pole (swing) and 12/10 pole (rotation) structure was assembled, and the experimental device was set up. The experimental results show that the experimental curve, analytical curve and FEM curve are in good agreement, which proves the accuracy of the equivalent model and is suitable for the magnetic field model of cylindrical and trapezoidal PM poles of the spherical motor. The research results of magnetic field lay a foundation for further analysis of the stator–rotor composite magnetic field considering cogging effect and edge effect, and analysis of load characteristics of the motor.
„Essengehen während die Patientin stirbt“
Psychoanalytisches Fallverstehen in klassischen Balintgruppen, Gruppen- und
Teamsupervisionen
Authors: Schubert Matthias N. 
Published: June 2022

ZusammenfassungMichael Balint beschreibt für seine Methode der Balintgruppenarbeit eine
Reihe von Regeln, allesamt geraten, um in einem Gruppenprozess Zugänge
zu unbewussten Beziehungsdynamiken zu bekommen. Diese Methode ist in der
Reflexion der Beziehung von Ärzt*in und Patient*in gut
eingeführt und erprobt. Anhand einer supervisorischen Arbeit wird
verdeutlicht, inwieweit mit weniger methodischen Vorgaben in anderen als
medizinischen Feldern das Unbewusste professioneller Beziehungen verstanden
werden kann.
Warum und wie ich die Leitung meiner Balint-Gruppen verändert
habe
Authors: Kanzow Thomas 
Published: June 2022

ZusammenfassungBerichtet wird von einer anderen Konstruktion des Gruppenbeginns, die eine
deutlichere Identifikation mit der Gruppenarbeit, und über den
Sitzungsabschluss, der mehr Besinnung, auch des Referenten, mit sich bringt.
Nachgedacht wird über die Selbsterfahrungstendenz – „der
Patient als Herausforderung das Selbst“ – und warum
Balint-Arbeit nicht einem verwegenen psychosomatischen Anspruch, sondern
v. a. der Arbeitsökonomie des Einzelnen – „mir
gerecht zu werden“ – dient.
Recent Advances in Transition-Metal-Catalyzed Reactions of N-Tosylhydrazones
Authors: Pilania M. , Vaishya V. , Singhal R. , Kriplani T. 
Published: June 2022

Abstract
N-Tosylhydrazones are highly versatile precursors for in situ carbene formation and are frequently used in metal-catalyzed cross-coupling reactions. Due to their many applications in organic synthesis, including C–C, C–O, C–N, and C–S bond formation, N-tosylhydrazones have recently received much interest. They can be simply synthesized by reacting an aldehyde or ketone with N-tosylhydrazine to produce a solid N-tosylhydrazone, which is a ‘green’ precursor of diazo compounds. Using a suitable metal catalyst, N-tosylhydrazones show versatile substrate scope for the synthesis of substituted diaminopyrroles, chromenopyrazoles, alkenylpyrazoles, benzofuran thioethers, tetrahydropyridazines, sulfur-containing heterocycles, and benzofurans with potent biological activities and even regioselective N-functionalization reactions. Metal-catalyzed reactions of N-tosylhydrazones for the construction of bioactive heterocycles are still highly in demand. Hence, this review focuses on the recent synthetic application of N-tosylhydrazones influenced by different transition metals with notable features like simple workup procedures, gram-scale synthesis, broad substrate scope, multicomponent processes, cyclization, and carbon–heteroatom bond formation.1	Introduction2	Applications of N-Tosylhydrazones3	Conclusion
Fraturas intracapsulares do colo femoral no idoso
Authors: Queiroz Roberto Dantas , Borger Richard Armelin , Heitzmann Lourenço Galizia , Fingerhut David Jeronimo Peres , Saito Luiz Henrique 
Published: June 2022

ResumoAtualmente, a fratura intracapsular do colo femoral (FICF) ainda é um grande desafio para os ortopedistas. Apesar dos grandes avanços feitos, persiste uma grande taxa de mortalidade no primeiro ano, sobretudo no Brasil, onde não há uma conscientização de que tais fraturas nos pacientes idosos devem ser tratadas como uma urgência médica. O presente artigo busca fornecer uma atualização das condutas pré-operatórias, cirúrgicas e pós-operatórias.
Celiac Plexus Cryoneurolysis
Authors: Chary Aron , Edalat Faramarz 
Published: June 2022

AbstractIntractable, chronic abdominal pain from upper abdominal malignant and benign diseases is a significant challenge for healthcare providers and burden on the healthcare system. While opioid analgesics are commonly used to provide pain relief, the adverse effects of chronic opioid use cannot be overlooked. Celiac plexus neurolysis via chemical or thermal means represents an alternative minimally invasive approach to provide palliative pain relief and increase patients' quality of life. Through the use of computed tomography guidance, celiac plexus neurolysis can be performed by accurately targeting the celiac plexus, while minimizing risks to adjacent structures. Historically, celiac plexus neurolysis was performed via instillation of ethanol or phenol; however, within the past decade cryoablation has gained increasing use with potentially fewer side effects.
Intercostal Cryoneurolysis
Authors: Huang Junjian , Delijani Kevin , El Khudari Husamuddin , Gunn Andrew J. 
Published: June 2022

AbstractChest wall pain affects many patients following chest surgery, fractures, or malignancies, and can be very difficult to manage with normal pharmacologic agents. Intercostal ablation provides one alternative treatment modality for patients suffering from intercostal pain. Intercostal cryoneurolysis involves using extreme cold to cause Wallerian degeneration of the targeted intercostal nerve. This article reviews the patient selection, technique, and complications in the utilization of intercostal neurolysis in the treatment of intractable chest pain.
Interventional Palliation of Painful Extraspinal Musculoskeletal Metastases
Authors: Tomasian Anderanik , Jennings Jack W. 
Published: June 2022

AbstractThe musculoskeletal system is commonly involved by metastases, and skeletal-related events such as intractable pain due to direct osseous tumor involvement, pathologic fracture, and neurologic deficits as a result of nerve compression often adversely affect patient's quality of life. There have been substantial advances in percutaneous minimally invasive musculoskeletal oncologic interventions for the management of patients with musculoskeletal metastases including thermal ablations, cementation with or without osseous reinforcement via implants, osteosynthesis, neurolysis, and palliative injections which are progressively incorporated in clinical practice. These interventions are performed, in conjunction with or supplemented by adjuvant radiation therapy, systemic therapy, surgery, or analgesics, to achieve durable pain palliation, local tumor control, or cure. This article reviews minimally invasive percutaneous image-guided musculoskeletal oncologic interventions for the management of patients with extraspinal musculoskeletal metastases.
CT-Guided Cooled Radiofrequency Denervation for Chronic Arthritis Pain of the Hip and Shoulder
Authors: Sag Alan Alper , Patel Preet 
Published: June 2022

AbstractThe paradigm in the treatment of arthritis pain is shifting for previously open surgical denervations of the hip and shoulder, as it already has for the geniculate nerves in knee arthritis. Interventional radiology is poised to contribute to this space with the use of CT guidance to provide safe, fast, and effective targeting of the target nerves for unequivocal diagnostic nerve block and definitive cooled radiofrequency denervation. The authors provide the background of which nerves are targeted for hip and shoulder denervation and the normal CT appearance of these blocks.
Genicular Nerve Ablation Review Using Cooled-Radiofrequency Nerve Ablation
Authors: Tran Andrew , Reiter David A. , Cruz Anna R. , Gonzalez Felix M. 
Published: June 2022

AbstractOsteoarthritis (OA) is globally the most prevalent joint disease and causes patients great pain, limited joint mobility, and psychological distress. Short- and long-term therapies like steroid injections and arthroplasty exist, respectively. Joint arthroplasty can effectively treat symptomatic end-stage OA, but most patients do not go through with surgery because they are not qualified, have comorbidities, or do not wish to undergo surgery. As a result, patients can turn to opioid agonists for pain relief, which contributes to the growing opioid epidemic that mars our communities. Cooled radiofrequency ablation (C-RFA) is an effective treatment modality that can alleviate the pain associated with moderate to severe OA, especially in patients who have tried and failed conservative therapy. This review article elucidates the benefits of C-RFA, while also walking through the technical steps to performing the procedure. For patients suffering from debilitating joint OA, especially of the knee, C-RFA is a minimally invasive procedure that ensures pain relief.
Prophylaxis of Venous Thromboembolism in Children: A Systematic Review
Authors: Pedersen Lotte Hejberg , Villadsen Gitte Bonde , Hellfritzsch Maja , Hvas Anne-Mette 
Published: June 2022

AbstractVenous thromboembolism (VTE) in children is a rare but serious event. Current guidance on pharmacological thromboprophylaxis in children is mostly based on adult studies and expert opinions. The aim of this systematic review was to examine under which conditions children (age ≤ 18 years) would benefit from pharmacological thromboprophylaxis with low molecular weight heparin or unfractionated heparin. Eligible studies included children, who did not receive pharmacological thromboprophylaxis as comparator, and VTE events were radiologically verified. MEDLINE and Embase were searched up to October 3, 2021. Ten studies were included presenting data for 976 children receiving pharmacological thromboprophylaxis. We divided the studies into three categories based on the population studied: children in the intensive care unit (n = 2), children with fractures and/or undergoing surgery (n = 5), and children with systemic disease (n = 3). A lower incidence of VTE was found when pharmacological thromboprophylaxis was used compared with no prophylaxis in children in intensive care unit with central venous catheter and mechanical ventilation (7/27 vs. 13/24), children in the intensive care unit admitted after trauma with a very high risk of VTE based on several risk factors (0/21 vs. 13/96), and children with acute lymphoblastic leukemia treated with L-asparaginase concomitant with steroid and presence of central venous catheter (0/82 vs. 8/121). Pharmacological thromboprophylaxis was not associated with an increased bleeding risk. In conclusion, pharmacological thromboprophylaxis in children is sparsely investigated. Only children with several risk factors for VTE are likely to benefit from pharmacological thromboprophylaxis.
Does SARI Score Predict COVID-19 Positivity? A Retrospective Analysis of Emergency Department Patients in a Tertiary Hospital
Authors: Alghalyini Baraa , Shakir Ismail M. , Wahed Muaz M. , Babar Sultan M. , Mohamed Mohamed S. 
Published: June 2022

AbstractEffectively triaging incoming patients while preventing coronavirus disease 2019 (COVID-19) spread in any emergency department (ED) is a demanding and critical task that places a huge burden on frontline healthcare workers. The ED at our tertiary hospital utilized a slightly modified version of a formerly efficacious severe acute respiratory infections (SARI) screening tool for triaging patients presenting to the ED with respiratory illness. We conducted a retrospective chart review and included patients who were screened using the SARI screening tool and underwent a combined nasopharyngeal and oropharyngeal reverse transcription polymerase chain reaction swab for severe acute respiratory syndrome- related coronavirus 2 to determine COVID-19 positivity. Results from our study show that it may be warranted to remove the gastrointestinal symptoms (nausea, vomiting, and diarrhea) from the SARI screening tool and potentially adjusting the weights of the components in the screening tool. However, as data from additional studies become available, the current SARI screening tool could continue to be used as a screening tool to predict COVID-19 positivity and in triaging patients.
Protocolo de reabilitação acelerada precoce versus conservadora retardada após reconstrução do ligamento cruzado anterior: Um ensaio prospectivo randomizado
Authors: Patra Saroj Kumar , Nanda Saurav Narayan , Patro Bishnu Prasad , Sahu Nabin Kumar , Mohnaty Chitta Ranjan , Jain Mantu 
Published: June 2022

Resumo
Objetivo Comparar a eficácia dos protocolos de reabilitação acelerada precoce e de reabilitação conservadora retardada após reconstrução artroscópica do ligamento cruzado anterior, em termos da escala do International Knee Documentation Committee (IKDC), da dor (segundo a Escala Visual Analógica), da frouxidão e da rigidez no pós-operatório de um ano para determinar o melhor desfecho.
Materiais e Métodos Um total de 80 participantes foram divididos em dois grupos (grupo da acelerada precoce e grupo da conservadora retardada), que foram analisados pelos testes do Qui-quadrado de Pearson e da soma dos postos de Wilcoxon.
Resultados A frouxidão do joelho no pós-operatório de 1 ano foi significativamente mais alta (p = 0,039) no grupo da acelerada precoce do que no grupo da conservadora retardada. Em termos de dor pós-operatória (pela Escala Visual Analógica) e pontuações no IKDC, ambos os grupos apresentaram resultados similares. A amplitude de movimento pós-operatória foi melhor no grupo da acelerada precoce, mas isso não foi estatisticamente significativo (p = 0,36).
Conclusão O protocolo de reabilitação acelerada precoce foi associado com uma frouxidão significativa do joelho em um ano de pós-operatório em comparação com o protocolo de reabilitação conservadora retardada.
Synthesis and Characterization of Related Substances of Torasemide
Authors: Chen Jiong , Ming Wei , Fan De-Hua , Gu Shuang-Xi 
Published: June 2022

AbstractTorasemide, a pyridine-3-sulfonylurea derivative, is a high-efficiency loop diuretic. During the process development of torasemide, five process-related substances, which have been specified in the pharmacopeia, would be produced. In this study, all these related substances, including compounds A–E, were synthesized via simple procedures and subsequently characterized by 1H nuclear magnetic resonance (NMR), 13C NMR, and mass spectrometry. Particularly, a simple synthetic method for compound A has not been found in previous literature. It is worth noting that other related substances could be prepared from compound B in one or two steps. The availability of these related substances could allow for quality control in the process of torasemide.
Noise enhanced stability of an active particle in a spatial metastable potential driven by cross-correlated noises
Authors: Jia Zheng-Lin , Yang Chun-Yan , Ma Bao-Yu , Chen Ying 
Published: June 2022

Abstract
We investigate the escape dynamics of an active Brownian particle (ABP) in a spatial cubic potential subject to the cross-correlated multiplicative noise and additive noise. Based on the Schweitzer–Ebeling–Tilch model, the effects of noise strength, cross-correlation intensity between noises, damping coefficient and potential amplitude on the mean escape time (MET) from a metastable potential state are analyzed. The results indicate that the MET exhibits a non-monotonic behavior with a maximum as a function of the intensities of the multiplicative and additive noises, identifying the occurrence of the noise enhanced stability (NES) effects induced by the multiplicative noise and by the additive noise. The increase of the cross-correlation strength always enhances the NES effect induced by the additive noise, regardless of the cross-correlation between noises is positive or negative. However, the positive and negative cross-correlation play an opposite role on the NES effect induced by the multiplicative noise. Moreover, the NES effects induced by the additive and multiplicative noises can be enhanced by the increase of the damping coefficient and the potential amplitude. A physical mechanism for the NES effect of the ABP can be understood as the fact that a certain amount of noise can stabilize the sojourn of the ABP in a limit cycle. Our results demonstrate that the cross-correlation between noises may provide a possible strategy for controlling the stability of active particle systems.