bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of adenocarcinoma of the pancreatic tail in the elderly
Authors: Boutros Christina S. , Hue Jonathan J. , Elshami Mohamedraed , Rothermel Luke D. , Hoehn Richard S. , Ammori John B. , Winter Jordan M. , Ocuin Lee M. , Hardacre Jeffrey M. 
Published: October 2022

AbstractIntroductionElderly patients with adenocarcinoma of the pancreatic head can achieve reasonable survival with multimodal therapy. An analysis specific to cancers of the pancreatic tail has not been published.MethodsWe identified patients ≥65 years with localized adenocarcinoma of the pancreatic tail in the National Cancer Database (2011–2017). Patients were grouped by age (65–79 and ≥80 years) and categorized by treatment regimen. Postoperative outcomes and survival were analyzed using propensity score matching and multivariable logistical regression.Results2168 patients were included: 73.9% were 65–79 years and 26.1% were ≥80 years. 34.1% of octogenarians did not receive any treatment, relative to 15.9% of younger patients (p < 0.001). Thirty‐day mortality rates were similar in operatively managed patients; however, the 90‐day mortality rate among octogenarians was greater (3.0% vs. 7.8%, p < 0.001; odds ratio [OR] = 1.85, 95% confidence interval [CI] = 1.07‐3.19). Age ≥ 80 was not associated with survival on multivariable hazards regression (hazard ratio [HR] = 1.08, 95% CI = 0.95–1.24). After propensity matching, the addition of chemotherapy was not associated with improved survival relative to distal pancreatectomy alone among octogenarians (HR = 1.09, 95% CI = 0.72–1.65).ConclusionsManagement of adenocarcinoma of the pancreatic tail varies based on patient age. Resection appears to play a key role in management, but there is substantial upfront risk. Shared decision making should be employed to balance the chance for long‐term survival with the risk of early mortality.
Cognitive Assessment in Elderly Cochlear Implant Recipients: Long‐Term Analysis
Authors: Herzog Jacques A. , Buchman Craig A. , Kallogjeri Dorina , Chen Stephanie , Wick Cameron , Durakovic Nedim , Shew Matthew A. 
Published: October 2022

ObjectivesTo examine long‐term speech and cognition outcomes in older adult cochlear implant (CI) recipients. First, by evaluating if CI performance was maintained over an extended follow‐up period regardless of preoperative cognitive status. Secondly, by evaluating if there was a difference in the rate of cognitive decline between preoperative mild and normal cognition following CI over an extended period of time.Study Design and SettingRetrospective cohort study.MethodsCI recipients ≥65 years of age implanted between 2009 and 2014 with 4+ years follow up. Pre‐ and postoperative audiometric and speech outcome assessments were collected. Cognitive status was measured using the mini mental status examination (MMSE) at numerous time points.ResultsFifty‐three patients met inclusion. Patients were divided into two groups based on preoperative MMSE with scores considered normal (28–30) and those with mildly impaired cognition (MIC, scores 25–27). Audiometric and speech performance improved significantly at one‐year post implantation and this was maintained without significant change at 4+ years, regardless of cognitive status. Mixed modeling analysis controlling for age demonstrated no significant difference in the rate of cognitive decline at 4+ years post implantation between the normal cognition cohort (1.74; 95%CI 0.89–2.6) and MIC (2.9; 95%1.91–3.88).ConclusionSpeech performance was significantly improved and sustained after CI in both normal cognition and MIC patients. The rate of cognitive decline in older adult CI patients appears to be similar regardless of preoperative cognitive status. Although results demonstrate rates of cognitive decline following CI did not differ between cognition groups over 4+ years, future studies will need to further investigate this over extended time periods with a more comprehensive cognitive testing battery.Level of Evidence4 Laryngoscope, 133:2379–2387, 2023
Net primary productivity changes associated with landslides induced by the 2008 Wenchuan Earthquake
Authors: Yang Yinshuang , Fan Xuanmei , Wang Xin , Lv Linyi , Zou Chengbin , Feng Zetao 
Published: October 2022

AbstractThe 2008 Wenchuan Earthquake triggered massive landslide erosion, especially in mountainous terrain, which had a great impact on carbon storage of the local terrestrial ecosystem. However, variation in carbon flux and restoration of ecosystem function after the Wenchuan Earthquake remain open issues. In this study, we evaluated the current restored vegetation productive capability on the coseismic landslide scars through moderate resolution imaging spectroradiometer (MODIS) net primary productivity (NPP) imagery, and explored their sensitivity to meteorological, topographical, and geological factors. The spatio‐temporal evolution and future sustainability of NPP of the landslides after the Earthquake were revealed. The following results were obtained: (i) After 13 years, only 45.36% of the vegetation productivity capability of the landslide scars reached the pre‐earthquake level. (ii) Meteorological factors (precipitation and temperature) have strongest influences on vegetation productivity capability recovery over the coseismic landslide scars, followed by topography (aspect, slope, and altitude) and the lithology of landslides. (iii) The extremely significant improvement (p < 0.01) and significant improvement (0.01 ≤ p < 0.05) in annual NPP pixel values from 2008 to 2021 accounted for 18.92% and 28.30% of the total area, respectively. The slight degradation (p < 0.1) in annual NPP pixel values from 2008 to 2021 account for 0.01% of the total area. In general, the NPP has shown an improving trend since the Wenchuan Earthquake. Moreover, 60.95% of the total area shows the trends of continuous improvement in the future. This study provides important insight into how mega‐earthquakes affect regional ecosystem carbon flux and contributes to our understanding of ecosystem carbon cycles along with earthquake‐induced geohazard chains.
Anatomic and audiometric outcomes of porcine intestinal submucosa for tympanic membrane repair
Authors: Dontu Pragnya , Shaigany Kevin , Eisenman David Jeffrey 
Published: October 2022

AbstractObjectiveSurgical repair of tympanic membrane perforations has been traditionally performed with autologous soft‐tissue grafts with high success rates. Newer allografts such as porcine small intestine submucosa (pSIS) have been employed as alternatives to minimize donor morbidity and surgical time, and in cases where autologous tissue may not be available. The comparative anatomic and audiometric success rates of these tissues is still unclear.Study designRetrospective case–control series of anatomic and audiometric outcomes of autologous soft tissue versus pSIS graft for primary, isolated transmeatal tympanic membrane repair.MethodsAnalysis of patients undergoing primary transmeatal tympanic membrane repair with autologous soft tissue or pSIS. Patients with otorrhea, cholesteatoma or retraction pockets, those who had cartilage grafts or ossicular reconstruction, and revision procedures were excluded. Pre‐ and post‐surgery air–bone gaps (ABG) and pure tone averages (PTA) were compared. Graft success was defined as closure of the perforation at 2‐month follow‐up visit.ResultsThe success rate for both the autologous soft tissue and the pSIS arm is 93.8%. There was no statistical significance (p < .05) between the post‐op ABG, change in ABG, post‐op PTA, change in PTA, or graft success rate between the two groups with either lumped cohort or matched‐pairs analysis.ConclusionspSIS grafts are effective for repair of tympanic membrane perforations with hearing outcomes and graft success rates comparable to autologous soft tissue.Lay summaryRepair of tympanic membrane perforations is traditionally done using a soft‐tissue graft harvested from the patient at the time of surgery. pSIS is a newer graft material that is equally effective in terms of anatomical and audiometric outcomes.Level of evidenceLevel 3b.
Thiol‐yne 3D Printable Polymeric Resins for the Efficient Removal of a Model Pollutant from Waters
Authors: Shahzadi Lubna , Maya Fernando , Breadmore Michael C. , Thickett Stuart C. 
Published: October 2022

AbstractA new 3D printable resin formulation is developed and optimized from commercially available thiol (pentaerythritol tetrakis(3‐mercaptopropionate); PETMP) and alkyne (3‐butyn‐1‐ol; BA) monomers. Printed objects are characterized by Fourier‐transform infrared (FTIR) spectroscopy and thermogravimetric analysis (TGA). The extraction efficiency of the printed thiol‐yne device is then investigated using a model dye – malachite green (MG). The results displayed excellent dye removal efficiency with > 95% MG removed within 5 min. The 3D‐printed devices are reusable and show 100% removal over six cycles after washing with deionized water and methanol. The presence of surface hydroxyl groups derived from the BA monomer is shown to enhance dye adsorption in comparison to control materials. The printing procedure and resin formulation are robust and consistent when devices from different resin batches are compared for MG dye removal. The thiol‐yne 3D printed devices demonstrated excellent dye removal (> 99%) from water samples collected from a tap and a nearby river source. The successful development of this resin provides a new thiol‐yne‐based resin system for stereolithography (SLA) 3D printing for the removal of organic dyes from wastewater and presents a potential for broad applications in water treatment.
A Review on Current Nanofiber Technologies: Electrospinning, Centrifugal Spinning, and Electro‐Centrifugal Spinning
Authors: Xu Huaizhong , Yagi Shinichi , Ashour Sherry , Du Lei , Hoque Md Enamul , Tan Lin 
Published: October 2022

AbstractNanofiber‐based products are widely used in the fields of public health, air/water filtration, energy storage, etc. The demand for nonwoven products is rapidly increasing especially after COVID‐19 pandemic. Electrospinning is the most popular technology to produce nanofiber‐based products from various kinds of materials in bench and commercial scales. While centrifugal spinning and electro‐centrifugal spinning are considered to be the other two well‐known technologies to fabricate nanofibers. However, their developments are restricted mainly due to the unnormalized spinning devices and spinning principles. High solution concentration and high production efficiency are the two main strengths of centrifugal spinning, but beaded fibers can be formed easily due to air perturbation or device vibration. Electro‐centrifugal spinning is formed by introducing a high voltage electrostatic field into the centrifugal spinning system, which suppresses the formation of beaded fibers and results in producing elegant nanofibers. It is believed that electrospinning can be replaced by electro‐centrifugal spinning in some specific application areas. This article gives an overview on the existing devices and the crucial processing parameters of these nanofiber technologies, also constructive suggestions are proposed to facilitate the development of centrifugal and electro‐centrifugal spinning.
You ought to know: Why consumers think companies can foresee bad (but not good) side effects
Authors: Reich Brandon J. , Laurent Sean M. 
Published: October 2022

AbstractRoutine business activities often lead to unintended side effects. Prior research suggests that consumers ascribe greater corporate foreknowledge when side effects are harmful (vs. helpful) but offers a controversial explanation and insufficient exploration of its consequences. The current research fills these gaps, offering a heuristic‐based explanation steeped in consumer behavior, while demonstrating the importance of this asymmetry to consumer response. First, a Pilot Study confirms the theoretical processes underlying our explanation. Study 1 tests the role of this foreknowledge asymmetry in predicting implicit bias toward the company. Studies 2 and 3 provide moderation evidence for our heuristic‐based explanation and connect the phenomenon to motive inferences and blame judgments, respectively. In sum, this work provides a novel explanation for a common marketplace phenomenon while establishing its effects on several important consumer response variables.
Mutational profiling of circulating tumor DNA and clinical characteristics in lymphoma: Based on next generation sequencing
Authors: Hou Yue , Zi Jie , Liu Shuo , Ge Qinyu , Ge Zheng 
Published: October 2022

AbstractLiquid biopsy has been experimented with to identify the mutation of lymphoma based on next‐generation sequencing (NGS). We applied NGS analysis to circulating tumor DNA (ctDNA) in 20 lymphoma patients. Then, we compared treatment outcomes, and clinical characteristics among these patients, then investigated mutational profiling. Two independent cohorts of 241 patients with mature B cell lymphoma in Mature B‐cell malignancies data set (MBN) data set and 50 diffuse large B‐cell lymphoma (DLBCL) patients in DLBCL data set, were used to examine the association between gene mutations and prognosis. We found ctDNA positive group had significantly more relapsed/PD (7/12, 58.3%) and less CR/PR patients (1/12, 8.3%) compared to negative group (0, 0%) (5/8, 62.5%) (p < 0.001). Somatic alterations were identified in 12 of 20 patients and the total 11 mutations were: Ataxia telangiectasia mutated (ATM), TP53, BCL2, BTG2, CD28, EP300, IDH2, IRF8, JAK3, NOTCH1, and NRAS. ATM (S2168L) was found in SLL and TLBL for the first time. BTG2 (c.292_293del), CD28 (P119T), IRF8 (E74D) and NOTCH1 (c.4348 G > A) were newly detected in DLBCL, angioimmunoblastic T‐cell lymphoma, primary central nervous system lymphoma, and BCL for the first time respectively. We also disclosed an unreported mutation EP300 (c.1058_1059insC) in DLBCL. Our cases implied ctDNA detection consistent with the FISH of tissue samples to some extent, speculating new molecular subtypes of DLBCL, finding some potential drug‐resistant mutations, and suggesting disease recurrence. Moreover, in MBN and DLBCL datasets, patients with TP53 mutation had a significantly shorter OS (all p < 0.05) in both circulating free DNA and tumor tissue. The mutations (no SNP) of NOTCH1 (all p < 0.05) significantly contributed to worse OS in the two cohorts.
High‐resolution climate characteristics of the Arabian Gulf based on a validated regional reanalysis
Authors: Dasari Hari Prasad , Viswanadhapalli Yesubabu , Langodan Sabique , Abualnaja Yasser , Desamsetti Srinivas , Vankayalapati Koteswararao , Thang Luong , Hoteit Ibrahim 
Published: October 2022

AbstractThe regional climate of the Arabian Gulf (AG) and its variability are examined based on a 40‐year (1980–2019), 5‐km regional reanalysis of the Arabian Peninsula (AP reanalysis). The AP reanalysis fields were first validated against the available observations over the AG, suggesting that this high‐resolution reanalysis well reproduces the spatio‐temporal features of the AG atmospheric circulations. The validated AP reanalysis fields were then analysed to examine the climatic characteristics over the AG including the monthly mean, maximum and minimum temperatures, and the seasonal variations in winds, relative humidity and rainfall over the AG. The AG climate is mostly dry between May and October, and experiences moderate rainfall between December and January. The higher (lower) pressure difference between the northwest and southeast AG during summer (winter) generates the northwesterly Shamal winds over the north (central) AG. The mean Shamal winds are relatively stronger (weaker) and prolonged (shorter) during summer (winter); however, the short lived Shamal jet events in winter can be occasionally stronger than summer. In terms of interannual variability, the Shamal winds are stronger and more persistent in summer during El Niño years and in winter during La Niña years. These differences are mainly associated with changes in temperature gradients between the eastern AG and northwestern AP.
Inhibitor Assessment against the LpxC Enzyme of Antibiotic‐resistant Acinetobacter baumannii Using Virtual Screening, Dynamics Simulation, and in vitro Assays
Authors: Zoghlami Manel , Oueslati Maroua , Basharat Zarrin , Sadfi‐Zouaoui Najla , Messaoudi Abdelmonaem 
Published: October 2022

AbstractBackground: Bacterial resistance is currently a significant global public health problem. Acinetobacter baumannii has been ranked in the list of the World Health Organization as the most critical and priority pathogen for which new antibiotics are urgently needed. In this context, computational methods play a central role in the modern drug discovery process. The purpose of the current study was to identify new potential therapeutic molecules to neutralize MDR A. baumannii bacteria. Methods: A total of 3686 proteins retrieved from the A. baumannii proteome were subjected to subtractive proteomic analysis to narrow down the spectrum of drug targets. The SWISS‐MODEL server was used to perform a 3D homology model of the selected target protein. The SAVES server was used to evaluate the overall quality of the model. A dataset of 74500 analogues retrieved from the PubChem database was docked with LpxC using the AutoDock software. Results: In this study, we predicted a putative new inhibitor for the Lpxc enzyme of A. baumannii. The LpxC enzyme was selected as the most appropriate drug target for A. baumannii. According to the virtual screening results, N‐[(2S)‐3‐amino‐1‐(hydroxyamino)‐1‐oxopropan‐2‐yl]‐4‐(4‐bromophenyl) benzamide (CS250) could be a promising drug candidate targeting the LpxC enzyme. This molecule shows polar interactions with six amino acids and non‐polar interactions with eight other residues. In vitro experimental validation was performed through the inhibition assay. Conclusion: To the best of our knowledge, this is the first study that suggests CS250 as a promising inhibitory molecule that can be exploited to target this gram‐negative pathogen.
Considerations on boundary conditions in transformation optics for complete field computation in generic waveguides
Authors: Gentili Gian Guido , Giannetti Giacomo , Pelosi Giuseppe , Selleri Stefano 
Published: October 2022

AbstractTransformation optics is a powerful tool allowing remapping a generic domain into another yet maintaining a correspondence of the solution of Maxwell's equations within the two domains. Transformation optics has been used in the past to conveniently solve for modes in a generic waveguide by transforming its cross‐section into a circular one. Such a transformation needs particular care in enforcing boundary conditions in the transformed, circular, domain. In this paper, a theoretical treatment of boundary conditions is presented, allowing for an accurate computation of all field components in a generic waveguide.
Multiband millimeter‐wave patch antenna with parasitic element
Authors: Abo. El‐Hassan M. , Farahat Asmaa E. , Hussein Khalid. F. A. 
Published: October 2022

AbstractThe present paper introduces a novel design of a triple‐band millimeter‐wave printed antenna. The proposed antenna radiates at 28 and 43 GHz as its first‐order and second‐order resonances, respectively. Also, the antenna is designed to radiate efficiently in a third higher frequency band of about 2 GHz bandwidth (from 46 to 48 GHz). The design method depends on a composite‐patch structure where the primary radiating element is a circular patch of modified geometry to radiate at 28 and 43 GHz. An arc‐shaped parasitic printed element is capacitively‐coupled to the primary patch so that it can efficiently radiate over the wideband (46–48 GHz). The primary patch is fed through a microstrip line with an inset feed for impedance matching over the desired frequency bands. The antenna structure and the feeding line are printed on a thin dielectric substrate of low loss to be suitable for millimeter‐wave operation. The antenna has high radiation efficiency, excellent impedance matching, and satisfactory values of the antenna gain over the operational frequency bands. A prototype is fabricated and subjected to experimental assessment of the antenna performance including the return loss and radiation patterns. It is shown that the experimental measurements are in agreement with the simulation results over the three frequency bands.
Enhancing linguistic research through 2‐mm isotropic 3D dynamic speech MRI optimized by sparse temporal sampling and low‐rank reconstruction
Authors: Jin Riwei , Shosted Ryan K. , Xing Fangxu , Gilbert Imani R. , Perry Jamie L. , Woo Jonghye , Liang Zhi‐Pei , Sutton Bradley P. 
Published: October 2022

PurposeTo enable a more comprehensive view of articulations during speech through near‐isotropic 3D dynamic MRI with high spatiotemporal resolution and large vocal‐tract coverage.MethodsUsing partial separability model‐based low‐rank reconstruction coupled with a sparse acquisition of both spatial and temporal models, we are able to achieve near‐isotropic resolution 3D imaging with a high frame rate. The total acquisition time of the speech acquisition is shortened by introducing a sparse temporal sampling that interleaves one temporal navigator with four randomized phase and slice‐encoded imaging samples. Memory and computation time are improved through compressing coils based on the region of interest for low‐rank constrained reconstruction with an edge‐preserving spatial penalty.ResultsThe proposed method has been evaluated through experiments on several speech samples, including a standard reading passage. A near‐isotropic 1.875 × 1.875 × 2 mm3 spatial resolution, 64‐mm through‐plane coverage, and a 35.6‐fps temporal resolution are achieved. Investigations and analysis on specific speech samples support novel insights into nonsymmetric tongue movement, velum raising, and coarticulation events with adequate visualization of rapid articulatory movements.ConclusionThree‐dimensional dynamic images of the vocal tract structures during speech with high spatiotemporal resolution and axial coverage is capable of enhancing linguistic research, enabling visualization of soft tissue motions that are not possible with other modalities.
An improved asymmetric susceptibility tensor imaging model with frequency offset correction
Authors: Feng Ruimin , Cao Steven , Zhuang Jie , Zhao Jiayi , Guan Xiaojun , Zhang Yuyao , Liu Chunlei , Wei Hongjiang 
Published: October 2022

PurposeTo improve susceptibility tensor imaging (STI) reconstruction using the asymmetric STI model with the correction of non‐bulk‐magnetic‐susceptibility (NBMS) effects.MethodA frequency offset term was introduced into the asymmetric STI model to account for the bias between measured MRI frequency signals and conventional susceptibility tensor models because of NBMS contributions. Experiments were conducted to compare the proposed model with conventional STI, conventional STI with the proposed frequency offset correction, and asymmetric STI on simulation, ex vivo mouse brain, and in vivo human brain data.ResultsIn the simulation where NBMS contributions are head rotation‐invariant, the proposed method achieves the lowest errors in mean magnetic susceptibility (MMS) and magnetic susceptibility anisotropy (MSA) and is more robust to noise in the estimation of principal eigenvector (PEV). When considering the head orientation dependency of NBMS contributions, the proposed method shows advantages in estimating MSA and PEV. On the mouse and human brain data, the proposed method produces more reliable MSA maps and more consistent white matter fiber directions when referring to those from DTI than the compared STI methods.ConclusionThe proposed method can reduce the effects of NBMS‐related frequency shifts on the susceptibility tensors in the brain white matter. This study inspires STI reconstruction from the perspective of better modeling the sources of frequency shifts.