bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of hair follicles in the pathogenesis of arsenical‐induced cutaneous damage
Authors: Srivastava Ritesh K. , Wang Yong , Khan Jasim , Muzaffar Suhail , Lee Madison B. , Weng Zhiping , Croutch Claire , Agarwal Anupam , Deshane Jessy , Athar Mohammad 
Published: June 2022

AbstractArsenical vesicants cause skin inflammation, blistering, and pain. The lack of appropriate animal models causes difficulty in defining their molecular pathogenesis. Here, Ptch1+/–/C57BL/6 mice were employed to investigate the pathobiology of the arsenicals lewisite and phenylarsine oxide (PAO). Following lewisite or PAO challenge (24 h), the skin of animals becomes grayish‐white, thick, leathery, and wrinkled with increased bi‐fold thickness, Draize score, and necrotic patches. In histopathology, infiltrating leukocytes (macrophages and neutrophils), epidermal–dermal separation, edema, apoptotic cells, and disruption of tight and adherens junction proteins can be visualized. PCR arrays and nanoString analyses showed significant increases in cytokines/chemokines and other proinflammatory mediators. As hair follicles (HFs), which provide an immune‐privileged environment, may affect immune cell trafficking and consequent inflammatory responses, we compared the pathogenesis of these chemicals in this model to that in Ptch1+/–/SKH‐1 hairless mice. Ptch1+/–/SKH‐1 mice have rudimentary, whereas Ptch1+/–/C57BL/6 mice have well‐developed HFs. Although no significant differences were observed in qualitative inflammatory responses between the two strains, levels of cytokines/chemokines differed. Importantly, the mechanism of inflammation was identical; both reactive oxygen species induction and consequent activation of unfolded protein response signaling were similar. These data reveal that the acute molecular pathogenesis of arsenicals in these two murine models is similar.
Electrical stimulation through conductive scaffolds for cardiomyocyte tissue engineering: Systematic review and narrative synthesis
Authors: Scott Louie , Elídóttir Katrín , Jeevaratnam Kamalan , Jurewicz Izabela , Lewis Rebecca 
Published: June 2022

AbstractElectrical conductivity is of great significance to cardiac tissue engineering and permits the use of electrical stimulation in mimicking cardiac pacing. The development of biomaterials for tissue engineering can incorporate physical properties that are uncommon to standard cell culture and can facilitate improved cardiomyocyte function. In this review, the PICOT question asks, “How has the application of external electrical stimulation in conductive scaffolds for tissue engineering affected cardiomyocyte behavior in in vitro cell culture?” The Preferred Reporting Items for Systematic Reviews and Meta‐Analysis guidelines, with predetermined inclusion and quality appraisal criteria, were used to assess publications from PubMed, Web of Science, and Scopus. Results revealed carbon nanotubes to be the most common conductive agent in biomaterials and rodent‐sourced cell types as the most common cardiomyocytes used. To assess cardiomyocytes, immunofluorescence was used most often, utilizing proteins, such as connexin 43, cardiac α‐actinin, and cardiac troponins. It was determined that the modal average stimulation protocol comprised 1–3 V square biphasic 50‐ms pulses at 1 Hz, applied toward the end of cell culture. The addition of electrical stimulation to in vitro culture has exemplified it as a powerful tool for cardiac tissue engineering and brings researchers closer to creating optimal artificial cardiac tissue constructs.
ATLANTIC HALBERDS AS BELL BEAKER WEAPONS IN IBERIA: TOMB 1 OF HUMANEJOS (PARLA, MADRID, SPAIN)
Authors: Garrido‐Pena Rafael , Flores Fernández Raúl , Herrero‐Corral Ana M. , Muñoz Moro Pedro , Gutiérrez Saez Carmen , Paulos‐Bravo Rodrigo 
Published: June 2022

SummaryThe recent discovery of an Atlantic halberd among other abundant and rich grave goods in the Bell Beaker double tomb 1 of Humanejos (Parla, Madrid) demonstrates that this type of weapon was part of the Beaker panoply. It is the first example of an Atlantic halberd in a Beaker burial context in Iberia and only the second one in Europe. The remaining halberds come from old and isolated finds in Early Bronze Age deposits that were usually interpreted as post‐Beaker votive deposits. In this paper the Humanejos halberd and its archaeological context (human remains, burial structure, radiocarbon dates) are carefully examined. The study includes the technical analysis of the halberd (metal composition, lead isotopes, use‐wear traces), together with the other metallic weapons and tools recovered with it (Palmela points, tanged dagger, awl) as well as the rest of the offerings (Beaker pottery, ivory and bone adornments). All these data suggest that this exceptionally rich grave could have held a woman and a man of the social elite, with the power to concentrate important amounts of precious raw materials (copper, gold, ivory, cinnabar) in few hands, especially when compared to other contemporary graves in the same site and region.
A novel mannose‐containing sialoprotein adhesin involved in the binding of Candida albicans cells to DMBT1
Authors: Setoguchi Daisuke , Nagata Emi , Oho Takahiko 
Published: June 2022

AbstractCandida albicans colonizes the oral cavity and causes oral candidiasis and early childhood caries synergistically with cariogenic Streptococcus mutans. Colonization of oral tissues with C. albicans is an essential step in the initiation of these infectious diseases. Deleted in malignant brain tumors 1 (DMBT1), also known as salivary agglutinin or gp‐340, belongs to the scavenger receptor cysteine‐rich (SRCR) superfamily and has important functions in innate immunity. In the oral cavity, DMBT1 causes microbial adherence to tooth enamel and oral mucosa surfaces, but the adherence of C. albicans to DMBT1 has not been examined. In this study, we investigated the binding of C. albicans to DMBT1 and isolated the fungal components responsible for the binding. Candida albicans specifically bound to DMBT1 and strongly bound to the peptide domain SRCRP2. Binding to SRCRP2 was inhibited by N‐acetylneuraminic acid and mannose and by lectins recognizing these sugars. The isolated component had a molecular mass of 25 kDa, contained sialic acid and mannose residues, and inhibited C. albicans binding to SRCRP2. The localization of the 25‐kDa protein on the surface of C. albicans cell walls was confirmed by immunostaining and a cell ELISA using an antiserum to the protein, and Western blotting revealed the presence of the 25‐kDa protein in the cell wall fraction of C. albicans. These results suggest that the isolated adhesin is localized on the surface of C. albicans cell walls and that sialic acid and mannose residues in the adhesin play a significant role in the binding reaction.
Women's Legal Rights and Gender Gaps in Property Ownership in Developing Countries
Authors: Gaddis Isis , Lahoti Rahul , Swaminathan Hema 
Published: June 2022

AbstractWomen's property ownership matters for their well‐being and agency, broader economic prosperity, and children's development. However, until recently, a lack of data has constrained further exploration of gender differences in property ownership in the developing world. Using data from 41 developing countries, this paper contributes to the literature by investigating gender gaps in the incidence of property ownership among couples and the factors associated with these gaps, focusing on the role of legal systems. We find that in almost all countries, husbands are more likely to own property than wives. Across countries in our sample, husbands are, on average, 2.7 times more like than wives to own property alone and 1.4 times more likely to own property alone or jointly. Within countries, gender gaps in the incidence of property ownership are most pronounced for disadvantaged groups, that is, the rural population and the poorest quintile. These gender gaps reflect a variety of factors, including discriminatory laws with respect to inheritance, property ownership, marital regimes, and laws that protect from workplace discrimination. Countries with more gender egalitarian legal regimes have higher levels of property ownership by married women, especially housing, suggesting that legal reforms are a potential mechanism to increase women's property ownership.
Interplay between LHCSR proteins and state transitions governs the NPQ response in Chlamydomonas during light fluctuations
Authors: Steen Collin J. , Burlacot Adrien , Short Audrey H. , Niyogi Krishna K. , Fleming Graham R. 
Published: June 2022

AbstractPhotosynthetic organisms use sunlight as the primary energy source to fix CO2. However, in nature, light energy is highly variable, reaching levels of saturation for periods ranging from milliseconds to hours. In the green microalga Chlamydomonas reinhardtii, safe dissipation of excess light energy by nonphotochemical quenching (NPQ) is mediated by light‐harvesting complex stress‐related (LHCSR) proteins and redistribution of light‐harvesting antennae between the photosystems (state transition). Although each component underlying NPQ has been documented, their relative contributions to NPQ under fluctuating light conditions remain unknown. Here, by monitoring NPQ in intact cells throughout high light/dark cycles of various illumination periods, we find that the dynamics of NPQ depend on the timescales of light fluctuations. We show that LHCSRs play a major role during the light phases of light fluctuations and describe their role in growth under rapid light fluctuations. We further reveal an activation of NPQ during the dark phases of all high light/dark cycles and show that this phenomenon arises from state transition. Finally, we show that LHCSRs and state transition synergistically cooperate to enable NPQ response during light fluctuations. These results highlight the dynamic functioning of photoprotection under light fluctuations and open a new way to systematically characterize the photosynthetic response to an ever‐changing light environment.
Chloro‐aluminum phthalocyanine‐mediated photodynamic therapy in the treatment of stage‐II chronic periodontitis among smokers
Authors: Al‐Kheraif Abdulaziz A. , Alshahrani Obaid Abdullah , Al‐Shehri Abdullah M. , Khan Aftab Ahmed 
Published: June 2022

AbstractPurposeTo assess the clinical periodontal, bacterial, and immunological outcomes of chloro‐aluminum phthalocyanine‐mediated photodynamic therapy (PDT) as an adjunct to dental scaling (DS) versus DS alone among cigarette smokers (CS) and never‐smokers (NS).MethodsA total of 26 patients (13 CS and 13 NS) with clinical and radiographic diagnosis of stage‐II chronic periodontitis were recruited. Each patient from both groups were subjected with two parallel therapies (split‐mouth): PDT + DS (test side) and DS alone (control side). Periodontal parameters were investigated by evaluating plaque scores (PS), bleeding on probing (BOP), probing depth (PD), clinical attachment loss (CAL), and alveolar bone loss (ABL). Subgingival plaque was collected to detect and quantify Porphyromonas gingivalis and Tannerella forsythia using real‐time quantitative polymerase chain reaction (RT‐qPCR) assay. Gingival crevicular fluid was sampled for the quantification of interleukin (IL)‐1β and tumor necrosis factor‐alpha (TNF‐α) using enzyme linked immunosorbent assay. All assessments were performed at baseline, 3 months, and 6 months.ResultsBleeding on probing was significantly reduced at 6 months after PDT + DS in CS groups (p < .05). Mean PD and CAL significantly reduced after both PDT + DS and DS subgroups and among NS and CS groups (p < .05). At 6 months follow‐up, the copy number of both P. gingivalis and T. forsythia remained significantly high in CS group (p < .01). Only PDT + DS subgroup in CS significantly reduced the counts of P. gingivalis and T. forsythia at 3 months and 6 months (p < .05). Only at 6 months did PDT + DS showed statistically significantly reduced IL‐1β levels in the NS group (p < .01). TNF‐α levels significantly reduced in CS group with PDT + DS and DS alone at both 3 months and 6 months follow‐up (p < .01).ConclusionChloro‐aluminum phthalocyanine‐mediated PDT helped to improve the non‐surgical periodontal therapy outcomes among stage‐II chronic periodontitis patients among smokers and never‐smokers.
Clinical characteristics and outcomes of IgG4‐positive marginal zone lymphoma: Systematic scoping review
Authors: Nishimura Yoshito , Wien Eric Andrew , Nishimura Midori Filiz , Nishikori Asami , Sato Yasuharu , Otsuka Fumio 
Published: June 2022

AbstractImmunoglobulin G4 (IgG4)‐positive marginal zone lymphoma (MZL) is rare and undefined. It is unclear whether IgG4‐positive MZLs have as favorable an outcome as MZLs in general. Also, correlation with IgG4‐related disease (IgG4‐RD) and IgG4‐positive MZLs is unknown. Following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses extension for scoping reviews, we searched MEDLINE and EMBASE for all peer‐reviewed articles using keywords including“IgG4” and “marginal zone lymphoma” from their inception to February 20, 2022. Twenty‐two articles, including six observational studies and 24 cases from 16 case reports and case series, were included. Only one study had a comparative group, and the other five were exploratory observational studies. IgG4‐positive MZLs commonly occurred in males (83.3%). It primarily involved ocular adnexa (41.7%) and skin (29.2%). Only 29.2% had concurrent IgG4‐RD, and no expiration was noted. While most cases were treated with excision, resection, or clinical observation, 21.7% received rituximab‐cyclophosphamide, doxorubicin, vincristine, and prednisone as a first‐line treatment. This systematic review summarizes the current understanding of the characteristics of IgG4‐positive MZLs. While there seems to be IgG4‐RD‐related and de novo IgG4‐positive MZLs, future research needs to clearly define MZL with polyclonal IgG4‐positive cells and IgG4‐producing lymphoma. Further studies are critical to clarifying long‐term prognosis and optimal surveillance planning.
Children's and adolescents’ conversations with mothers about offenders’ and victims’ responsibility for harm in their experiences of being hurt by a peer
Authors: Saint‐Martin Anna , Badasu Mawuena , Recchia Holly , Wainryb Cecilia , Dirks Melanie 
Published: June 2022

AbstractThis study investigated mothers’ and children's constructions of meaning about responsibility for harm in conversations about two experiences when children were hurt by a peer and felt they had either contributed or not contributed to the situation. The sample included 105 Canadian mothers (75% White) and their children (53 girls, 52 boys) across three age groups (M ages = 6.92, 11.14, 15.89 years). Overall, mothers and children emphasized different aspects of responsibility; mothers made more evaluations of acts and discussed the avoidability of harm whereas children referred more to hurtful acts, consequences, reasons, and subsequent responses. Discussions of the child's and peer's responsibility were responsive to the child's perspective on events. The child's responsibility for self‐protection was particularly emphasized by mothers and when the child felt they had not contributed to the situation. Children more often mitigated their responsibility as compared to their mothers, and older children referred more to their own and their peer's responsibility for harm. Findings illuminate how conversations with mothers may inform children's judgments of their own and others’ roles in peer conflict.
Determinantes del consumo de bebidas azucaradas y estrategias de intervención relacionadas con su ingesta. Una revisión de enfoque.
Authors: Mantilla Caicedo Gilma Constanza , Robelto A Gloria E. , Olaya V Gilma , Fonseca N María F. , Herrera Angela V. , Otálora B María C. 
Published: June 2022

Introducción: El consumo de bebidas azucaradas (SSB, por sus siglas en inglés) se ha reportado como un problema de salud pública por su relación con la aparición de las enfermedades crónicas no transmisibles. Objetivo: Analizar los determinantes relacionados con el consumo de bebidas azucaradas y las intervenciones realizadas para reducir el consumo. Método: Una revisión de literatura a partir de la consulta en nueve bases de datos, se incluyeron publicaciones durante el periodo 2010 - 2021, los cuales se consolidaron en una matriz en Excel. Los artículos se analizaron con base en 4 niveles de análisis para 4 categorías de determinantes y 1 de intervenciones. Resultados: Se incluyeron 79 artículos. En Latinoamérica, se obtuvieron 18 resultados de México, Brasil, Chile, Argentina y Perú. A nivel Colombia se encontraron 12 artículos, adicionales a 9 realizados en Bogotá en diferentes instituciones educativas, y a 3 en la Pontificia Universidad Javeriana (PUJ). Conclusiones: los principales determinantes del consumo de SSB son: bajos ingresos, ser adolescente o adulto joven, sexo masculino, limitado conocimiento sobre la relación entre las SSB y la salud y disponibilidad de alimentos con alta densidad calórica, entre otros. Las intervenciones más prometedoras son el impuesto a SSB y el rotulado frontal.
Dolor torácico y elevación del segmento ST en paciente de 21 años con hipertiroidismo en debut: Reporte de caso
Authors: Escamilla Osorio Mario Germán , Tabares Arboleda Maria Paz , Niño Mahecha Freyberson Enrique , Camargo Arenas Juan Fernando 
Published: June 2022

La tirotoxicosis es un trastorno endocrino común que se presenta con una amplia variedad de síntomas sistémicos y que afectan el aparato cardiovascular (1).
En la literatura, el hipertiroidismo se asocia a morbilidad y mortalidad cardiaca (2). Los síntomas relacionados con el aparato cardiovascular, como las palpitaciones o la angina, son una forma de presentación frecuente en los pacientes con hipertiroidismo. La estimulación adrenérgica, que se traduce en un aumento del gasto y contractibilidad cardiacas, puede inducir isquemia del miocardio (3), así como el vasoespasmo coronario transitorio que se informa hasta en el 20% de los pacientes con hipertiroidismo (4) y el efecto antagónico del calcio en el miocardio (5).
En esta revisión se presenta el caso de un paciente joven, sin antecedentes patológicos de importancia que consulta al servicio de urgencias por cuadro de dolor torácico, con electrocardiograma que muestra elevación del segmento ST, sin embargo, con cateterismo cardiaco que reporta coronarias sanas y ecocardiograma que evidencia trastorno segmentario de la contractilidad y disminución de la fracción de eyección del ventrículo izquierdo, atribuida a vasoespasmo coronario, por tirotoxicosis basado en los hallazgos de exámenes de laboratorio.
Reanimación cardiopulmonar. Cuando el corazón para ¿reanimar o acompañar?
Authors: Gempeler Fritz Eduardo , Olmos Muskus Natalia 
Published: June 2022

Resumen:
Las maniobras de resucitación cardiopulmonar (RCP) introducen un importante cambio de paradigma acerca de la reversibilidad de la muerte, que produce grandes expectativas en la población general incluso en los médicos. No obstante, a pesar de los avances médicos que han permitido obtener mejores desenlaces, la sobrevida a corto y largo plazo sigue siendo baja y en muchas ocasiones hay alteraciones significativas en la calidad de vida y funcionalidad de los sobrevivientes. Al conocer esta importante realidad surgen como una alternativa las ordenes de no reanimación (ONR) y diversas sociedades manifiestan la necesidad de instaurar indicaciones para el inicio y finalización de la RCP. Este articulo busca brindar herramientas que puedan ayudar en la toma de decisiones sobre las indicaciones de la RCP, así como generar una reflexión que permita reconocer nuestra limitación humana ante la muerte, entendiendo que en muchos casos lo mas beneficiosos será acompañar y no reanimar.

Palabras clave: Paro cardíaco, reanimación cardiopulmonar, órdenes de resucitación, bioética, ética clínica, directivas anticipadas
A Novel Classification Method to Random Samples for Efficient Reliability Sensitivity Analysis
Authors: Wu Jinhui , Zhang Dequan , Han Xu 
Published: June 2022

Abstract
Reliability sensitivity analysis is important to measure how uncertainties influence the reliability of mechanical systems. This study aims to propose an efficient computational method for reliability sensitivity analysis with high accuracy and efficiency. In this study, coordinates of some points on the limit state function are first calculated through Levenberg–Marquardt (LM) iterative algorithm, and the partial derivative of system response relative to uncertain variables is obtained. The coordinate mapping relation and the partial derivative mapping relation are then established by radial basis function neural network (RBFNN) according to these points calculated by the LM iterative algorithm. Following that, the failure samples can be screened out from the Monte Carlo simulation (MCS) sample set by the well-established mapping relations. Finally, the reliability sensitivity is calculated by these failure samples and kernel function, and the failure probability can be obtained correspondingly. Two benchmark examples and an application of industrial robot are used to demonstrate the effectiveness of the proposed method.
A Comparative Energy Analysis of Dynamic External Shadings for Office Buildings
Authors: Krarti Moncef 
Published: June 2022

Abstract
In this paper, the energy performance of dynamic instead of static shading devices is investigated for prototypical US office spaces. Specifically, six dynamic shading systems are considered to assess their ability to reduce heating and cooling thermal loads, total building energy use, and electrical peak demand. The most promising dynamic shading is the rotating overhang and is evaluated further using a wide range of design and operation conditions. It is found that rotating overhangs can provide effective and easily controllable dynamic shading systems for windows to reduce the energy consumption of US office buildings by up to 39% especially for mild US climates. Moreover, the rotating overhangs have the added benefit to support PV panels for on-site electricity generation. A series of sensitivity analysis results indicate that the performance of the dynamic external shading systems depends on its depth and orientation, the location climate, the window size, and the glazing type have significant impacts. For instance, the dynamic shading device can reduce annual heating and cooling energy end-use for an office space located in Boulder, CO, compared to no shading case by 19% for a window-to-wall ratio (WWR) of 15% and by 31% for a WWR of 30%.
Supplemental Material: Physical transport of magmatic sulfides promotes copper enrichment in hydrothermal ore fluids
Authors: Heinrich Christoph A , Connolly James A.D. 
Published: June 2022

<p>Stokes calculations with assumed model compositions; thermodynamic modeling method with data sources and sensitivity tests; comments on component diffusion in silicate melts; a mass balance estimate for Cu, Ag transfer by entrained sulfide melt; and supplemental references on methods and material properties. </p>
Supplemental Material: Unleashing alkali feldspar: Ra/Th ages and chemical and isotopic constraints on Holocene phonolite magmatism, Canary Islands
Authors: Brown Bryce S. , Ramos Frank C. , al. et 
Published: June 2022

<p>Samples, preparation, and methods; feldspar age variations resulting from late-stage assimilation; Figures S1–S4; and Tables S1–S4. </p>