bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of rs2910164 in miR-146a with type 2 diabetes mellitus: A case–control and meta-analysis study
Authors: Chang Wei-Wei , Wen Li-Ying , Zhang Liu , Tong Xin , Jin Yue-Long , Chen Gui-Mei 
Published: September 2022

ObjectiveSeveral studies have shown that miR-146a rs2910164 (C &gt; G) is associated with type 2 diabetes mellitus (T2DM) susceptibility, but the results are still controversial. This study is divided into two parts, and one is to explore the relationship between miR-146a rs2910164 polymorphism and the genetic susceptibility of T2DM in Chinese Han population. Second, a meta-analysis on the basis of a larger sample size was used to determine whether this is a susceptibility gene for T2DM.MethodsA case–control study including 574 T2DM patients and 596 controls was used to evaluate the association of miR-146a rs2910164 polymorphism with the risk of T2DM in Chinese Han People. Then, we systematically searched studies investigating the correlation between miR-146a rs2910164 polymorphism and T2DM susceptibility published before April 2022 from PubMed, Web of Science, Wanfang, and China National Knowledge Infrastructure database, and a meta-analysis including six studies was carried out. The results were expressed by odds ratio (OR) and its 95% confidence interval (95% CI).ResultsIn a case–control study, we found that there were no statistical differences in genotype frequencies between T2DM and control group. Subgroup analysis showed that, compared with the CC genotype, CG + GG genotype was associated with a decreased risk of T2DM in the subgroup of individuals ≥ 65 years old (OR = 0.75; 95% CI: 0.58–0.98; Padjusted = 0.032) and BMI &lt; 18.5 (OR = 0.16; 95% CI: 0.03–0.89; Padjusted = 0.037). In overall meta-analysis, significant heterogeneity was detected. No significant association between miR-146a rs2910164 polymorphism and T2DM was observed in all genetic models under random effects models. Subgroup analysis revealed that there was a significant difference in genotype frequencies between the T2DM and control group in recessive model (CC vs. CG + GG: OR = 1.79; 95% CI: 1.08–2.96; PQ = 0.307, I2 = 4.0%) and homozygote model (CC vs. GG: OR = 1.79; 95% CI: 1.07–3.00; PQ = 0.216, I2 = 34.7%) in Caucasians.ConclusionThe results of our study demonstrate that the miR-146a rs2910164 polymorphism might have ethnicity-dependent effects in T2DM and may be related to T2DM susceptibility in Caucasians.
Audible acoustic characteristics of epoxy resins with partial discharge
Authors: Zhang Guozhi , Chen Kang , Zhang Xiaoxing 
Published: September 2022

The epoxy resin is the main solid insulating material for electrical equipment. PD (partial discharge) is an important factor leading to epoxy resin aging or failure. Fault detection technology based on audible acoustic imaging has the advantages of real-time monitoring, visibility, and flexibility and is gradually being used in the field of electrical equipment insulation state monitoring. However, the audible voiceprint features of epoxy resins with typical PD defects are not clear, which is not conducive to effective detection and fault diagnosis. Therefore, in this study, the study of audible voiceprint features of epoxy resins with a metal burr, pollution, metal foreign matters, and surface discharge defects was carried out. The discharge audible signals were obtained, and their time and frequency domain features were analyzed. The results show that the discharge audible signals of four PD defects can reflect the occurrence of PD simultaneously with pulse current signals. But the characteristics are obviously different in the time domain, which are embodied in listening perception, persistence, amplitude, and phase. In the frequency domain, the frequency spectra of discharge audible signals of four defects are mainly 5–10 and 13–24 kHz. Furthermore, the three feature vectors of frequency spectrum complexity, high-frequency energy factor, and maximum frequency point are extracted, which can well distinguish the discharge audible signals of four PD defects.
Seeded phosphorus retention in fixed-bed laboratory columns by the use of apatites
Authors: Delgado-González Laura , Lartiges Bruno , Troesch Stéphane , Proietti Arnaud , Molle Pascal 
Published: September 2022

Phosphorus retention in small- and medium-sized wastewater treatment plants is crucial to preventing the eutrophication of downstream catchments. One popular solution in combination with treatment wetlands is the use of reactive filters for phosphorus retention; however, identifying a suitable substrate is not an easy task in this process. Apatites have already proven to be an effective alternative for phosphorus retention, yet more in-depth research is needed. This article uses two natural apatite materials, NA1 and NA2, introduced in four fixed-bed laboratory columns to assess their phosphorus retention capacity. Various inflow conditions are set for the NA1 substrate to evaluate the impact of calcium and biomass development on performance. The substrates show high phosphorus retention (&gt;16.8 g PO4-P/kg for NA1 and &gt;17.5 g PO4-P/kg for NA2) as well as high kinetic rate coefficients (1.45 and 1.70 h−1 for NA1 and NA2, respectively), with performances above 80% for both substrates. The maximum phosphorus retention capacity is not attained at the end of the experiments, despite their long duration (230 days) and the short hydraulic residence times applied (∼2 h), thus suggesting a long-term removal capacity. The NA1 column fed with a calcium-deficient synthetic solution displays just slightly reduced kinetic rates, most likely due to calcite and dolomite dissolution from the media. The column fed with treated wastewater does not reveal any significant reduction in hydraulic conductivity due to biomass development. No loss of permeability due to chemical clogging was observed in the other columns. Scanning electron microscopy indicates that phosphorus retention occurs by the precipitation of amorphous calcium phosphate for both natural apatites, thereby clearly demonstrating the implementation of seeding mechanisms. Such a retention process is sustainable, which suggests it may proceed over even higher retention capacities.
Identification of pyroptosis-related immune signature and drugs for ischemic stroke
Authors: Shi Shanshan , Zhang Qi , Qu Changda , Tang Yushi , Qu Yewei , Wen Shirong , Sun Ruohan , Pan Yujun 
Published: September 2022

Background: Ischemic stroke (IS) is a common and serious neurological disease, and multiple pathways of cell apoptosis are implicated in its pathogenesis. Recently, extensive studies have indicated that pyroptosis is involved in various diseases, especially cerebrovascular diseases. However, the exact mechanism of interaction between pyroptosis and IS is scarcely understood. Thus, we aimed to investigate the impact of pyroptosis on IS-mediated systemic inflammation.Methods: First, the RNA regulation patterns mediated by 33 pyroptosis-related genes identified in 20 IS samples and 20 matched-control samples were systematically evaluated. Second, a series of bioinformatics algorithms were used to investigate the contribution of PRGs to IS pathogenesis. We determined three composition classifiers of PRGs which potentially distinguished healthy samples from IS samples according to the risk score using single-variable logistic regression, LASSO-Cox regression, and multivariable logistic regression analyses. Third, 20 IS patients were classified by unsupervised consistent cluster analysis in relation to pyroptosis. The association between pyroptosis and systemic inflammation characteristics was explored, which was inclusive of immune reaction gene sets, infiltrating immunocytes and human leukocyte antigen genes.Results: We identified that AIM2, SCAF11, and TNF can regulate immuno-inflammatory responses after strokes via the production of inflammatory factors and activation of the immune cells. Meanwhile, we identified distinct expression patterns mediated by pyroptosis and revealed their immune characteristics, differentially expressed genes, signaling pathways, and target drugs.Conclusion: Our findings lay a foundation for further research on pyroptosis and IS systemic inflammation, to improve IS prognosis and its responses to immunotherapy.
Eptifibatide use in ischemic stroke patients undergoing endovascular thrombectomy: A matched cohort analysis
Authors: Rana Ameena , Yu Siyuan , Reid-Herrera Savina , Kamen Scott , Hunter Krystal , Shaikh Hamza , Jovin Tudor , Thon Olga R. , Patel Parth , Siegler James E. , Thon Jesse M. 
Published: September 2022

IntroductionSmall studies have suggested that eptifibatide (EPT) may be safe in acute ischemic stroke (AIS) following intravenous thrombolysis or during endovascular therapy (EVT) for large vessel occlusion (LVO). However, studies are called upon to better delineate the safety of EPT use during EVT.MethodsA comprehensive stroke center registry (09/2015-12/2020) of consecutive adults who had undergone EVT for anterior LVO was queried. Patients treated with EPT were matched with 2 control groups based on known factors associated with intracranial hemorrhage (ICH) risk - age, Alberta Stroke Program Early Computed Tomography Score (ASPECTS), and number of thrombectomy passes. Safety outcomes (intracranial hemorrhage [ICH], parenchymal hematoma [PH-2] grade hemorrhagic transformation, symptomatic ICH [sICH]) and efficacy outcomes (TICI 2B/3 recanalization, 24-h National Institutes of Health Stroke Scale [NIHSS] score), were compared between matched groups using descriptive statistics. In addition, multivariable logistic regression was used to assess for an association between EPT and PH-1/PH-2 grade hemorrhages.ResultsA total of 162 patients were included, 54 of whom (33%) received EPT. The rate of ICH was similar between groups (p = 0.62), while PH-2 was significantly more frequent with EPT (16.7% EPT vs. 3.7 vs. 1.9%; p = 0.009), but without significant differences in sICH (5.6% EPT vs. 7.4 vs. 3.7%; p = 0.72). Rates of TICI Score ≥ 2B were nominally higher with EPT use (83.3 vs. 77.8 vs. 77.8%, p = 0.70). Between the EPT and control groups, there were no differences in 24-h NIHSS (p = 0.09) or 90-day mortality (p = 0.58). Our adjusted multivariate analysis identified that the number of passes (p &lt; 0.01), EPT use (p &lt; 0.01), and tandem occlusion (p = 0.03) were independent predictors of PH1/PH2 grade hemorrhage. Additionally, every unit increase in number of passes resulted in a 1.5 times greater odds of a high-grade hemorrhagic transformation in EPT-treated patients (adjusted OR = 1.594).ConclusionIn this single-center analysis, EPT use during EVT was associated with a significantly higher rate of PH1/PH2 grade hemorrhages, but not with differences in sICH, 24-h NIHSS, or 90-day mortality. Randomized prospective trials are needed to determine the safety and efficacy of EPT in this population.
Vulnerable frequency as an independent prognostic factor for sudden sensorineural hearing loss
Authors: Liang Chaoqun , Fang Qi , Chen Hongjun , Wang Zhixian , Qiao Xiangyun , Liao Yaqi , Lv Chenxi , Chen Mo , Li Lingxue , Yang Jianming 
Published: September 2022

ObjectivesSudden sensorineural hearing loss (SSNHL) is a common otology emergency in the practice. Its severe hearing impairment and prognosis impair the quality of life. Given that cochlear hair cell vulnerability is not consistent across frequencies, this study aims to investigate the impact of frequency-specific hearing loss on prognosis in SSNHL.MethodsThe study included 255 patients with full-frequency SSNHL. The baseline, clinical, and hearing characteristics, as well as possible cardiovascular predictors in blood, were collected for analysis.ResultsThe 4,000 and 8,000 Hz hearing levels in the responder group were significantly lower than those in the non-responder group (p = 0.008, p &lt; 0.001), while the average hearing was not (p = 0.081). Logistic regression showed that only vertigo (OR, 95% CI, 0.265, 0.102–0.684, p = 0.006) and 8,000 Hz hearing level (OR, 95% CI, 0.943, 0.916–0.971, p &lt; 0.001) were strongly associated with treatment outcome.ConclusionsCompared with other frequencies, 8,000 Hz hearing level was closely related to prognosis in SSNHL. In an adjusted model, our study did not find an effect of mean hearing on prognosis in SSNHL. However, further multicenter prospective studies are needed for validation.
Effects and neuroprotective mechanisms of vagus nerve stimulation on cognitive impairment with traumatic brain injury in animal studies: A systematic review and meta-analysis
Authors: Zhang Han , Li Chun-liu , Qu Yun , Yang Yu-xuan , Du Juan , Zhao Yu 
Published: September 2022

IntroductionCognitive impairment is the main clinical feature after traumatic brain injury (TBI) and is usually characterized by attention deficits, memory loss, and decreased executive function. Vagus nerve stimulation (VNS) has been reported to show potential improvement in the cognition level after traumatic brain injury in clinical and preclinical studies. However, this topic has not yet been systematically reviewed in published literature. In this study, we present a systematic review and meta-analysis of the effects of VNS on cognitive function in animal models of TBI and their underlying mechanisms.MethodsWe performed a literature search on PubMed, PsycINFO, Web of Science, Embase, Scopus, and Cochrane Library from inception to December 2021 to identify studies describing the effects of VNS on animal models of TBI.ResultsOverall, nine studies were identified in animal models (36 mice, 268 rats, and 27 rabbits). An analysis of these studies showed that VNS can improve the performance of TBI animals in behavioral tests (beam walk test: SMD: 4.95; 95% confidence interval [CI]: 3.66, 6.23; p &lt; 0.00001) and locomotor placing tests (SMD: –2.39; 95% CI: –4.07, –0.71; p = 0.005), whereas it reduced brain edema (SMD: –1.58; 95% CI: –2.85, –0.31; p = 0. 01) and decrease TNF-α (SMD: –3.49; 95% CI: –5.78, –1.2; p = 0.003) and IL-1β (SMD: –2.84; 95% CI: –3.96, –1.71; p &lt; 0.00001) expression level in the brain tissue. However, the checklist for SYRCLE showed a moderate risk of bias (quality score between 30% and 60%), mainly because of the lack of sample size calculation, random assignment, and blinded assessment.ConclusionThe present review showed that VNS can effectively promote cognitive impairment and neuropathology in animal models of TBI. We hope that the results of this systematic review can be applied to improve the methodological quality of animal experiments on TBI, which will provide more important and conclusive evidence on the clinical value of VNS. To further confirm these results, there is a need for high-quality TBI animal studies with sufficient sample size and a more comprehensive outcome evaluation.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021290797, identifier: CRD42021290797.
Stent-assisted coiling using the Neuroform Atlas stent for treatment of aneurysms that recur after coil embolization
Authors: Dong Linggen , Wang Jiejun , Chen Xiheng , Zhang Longhui , Zhao Zhiqiang , Peng Qichen , Jin Zeping , Wu Jun , Lv Ming , Liu Peng 
Published: September 2022

ObjectiveTo evaluate the safety and efficacy of stent-assisted coiling (SAC) using the Neuroform Atlas stent for aneurysms that recur after coil embolization.MethodsWe retrospectively reviewed patients who underwent SAC using the Neuroform Atlas stent to treat aneurysms that recurred after coil embolization from November 2020 to November 2021. Patient and aneurysm characteristics, procedural details, complications, and angiographic and clinical follow-up outcomes were recorded and analyzed.ResultsEleven patients with 11 recurrent aneurysms were included for analysis. Atlas stent deployment was successful in all cases. Angiography immediately after the SAC procedure and at last follow-up showed complete occlusion in 10 patients (90.9%) and a residual neck in one (9.1%). Mean angiographic and clinical follow-ups were 9.2 and 10 months, respectively. A single procedure-related complication occurred, mildly blurred vision in the left eye, which recovered completely. No permanent morbidity or mortality occurred.ConclusionSAC using the Atlas stent to treat aneurysms that recur after coil embolization is safe and effective. Large-scale studies with long-term follow-up are warranted to confirm our results.
Adherence to the dietary approaches to stop hypertension diet and all-cause mortality in patients with a history of heart failure
Authors: Chou Ting-Yu , Liu Wei-Ju , Lee Chia-Lin , Wang Jun-Sing 
Published: September 2022

Background and aimsWe investigated the association of adherence to the Dietary Approaches to Stop Hypertension (DASH) diet with all-cause mortality in patients with a history of heart failure.MethodsWe analyzed data from the National Health and Nutrition Examination Survey (NHANES). Dietary information was obtained from a 24-h dietary recall interview. Adherence to the DASH diet was assessed using the DASH score. The primary outcome was all-cause mortality which was confirmed by the end of 2011. Weighted Cox proportional hazards regression models were used to determine the hazard ratios and 95% CI for the association of the DASH score and all-cause mortality with multivariate adjustment.ResultsThe median DASH score was 2 among the 832 study participants. There were 319 participants who died after a median follow-up duration of 4.7 years. A higher DASH score (&gt;2 vs. ≤ 2) was not associated with a decrease in the risk of all-cause mortality (adjusted HR 1.003, 95% CI 0.760–1.323, p = 0.983). With respect to the components of the DASH score, a lower sodium intake was not associated with a decreased risk of mortality (adjusted HR 1.045, 95% CI 0.738–1.478, p = 0.803).ConclusionA higher DASH score (&gt;2 vs. ≤ 2) was not associated with all-cause mortality in patients with heart failure.
The association between double-lumen tube versus bronchial blocker and postoperative pulmonary complications in patients after lung cancer surgery
Authors: Liu Wei , Jin Fan , Wang He-Mei , Yong Fang-Fang , Wu Zhen , Jia Hui-Qun 
Published: September 2022

BackgroundBoth double-lumen tube (DLT) and bronchial blocker (BB) are used for lung isolation in patients undergoing lung cancer surgery. However, the effects of different devices for lung isolation remain inconclusive. Present study was designed to investigate the association between the choice of the two devices and postoperative pulmonary complications (PPCs) in patients with lung cancer.MethodsIn this retrospective cohort study, patients who underwent lung cancer surgery between January 1, 2020 and October 31, 2020 were screened. Patients were divided into two groups according to different devices for lung isolation: DLT group and BB group. Primary outcome was the incidence of a composite of PPCs during postoperative in-hospital stay.ResultsA total of 1721 were enrolled for analysis, of them, 868 received DLT and 853 BB. A composite of PPCs was less common in patients with BB (25.1%, [214/853]) than those received DLT (37.9% [329/868] OR 0.582 95% CI 0.461-0.735 P &lt; 0.001). Respiratory infection was less common in BB group (14.4%, [123/853]) than DLT group (30.3%, [263/868], P&lt;0.001). The incidence of non-PPCs complications was not statistically significant between the 2 groups.ConclusionsFor patients undergoing surgery for lung cancer, the use of BB for lung isolation was associated with a reduced risk of PPCs when compared with DLT.
A phantom-based analysis for tracking intra-fraction pancreatic tumor motion by ultrasound imaging during radiation therapy
Authors: Ji Tianlong , Feng Ziwei , Sun Edward , Ng Sook Kien , Su Lin , Zhang Yin , Han Dong , Han-Oh Sarah , Iordachita Iulian , Lee Junghoon , Kazanzides Peter , Bell Muyinatu A. Lediju , Wong John , Ding Kai 
Published: September 2022

PurposeIn this study, we aim to further evaluate the accuracy of ultrasound tracking for intra-fraction pancreatic tumor motion during radiotherapy by a phantom-based study.MethodsTwelve patients with pancreatic cancer who were treated with stereotactic body radiation therapy were enrolled in this study. The displacement points of the respiratory cycle were acquired from 4DCT and transferred to a motion platform to mimic realistic breathing movements in our phantom study. An ultrasound abdominal phantom was placed and fixed in the motion platform. The ground truth of phantom movement was recorded by tracking an optical tracker attached to this phantom. One tumor inside the phantom was the tracking target. In the evaluation of the results, the monitoring results from the ultrasound system were compared with the phantom motion results from the infrared camera. Differences between infrared monitoring motion and ultrasound tracking motion were analyzed by calculating the root-mean-square error.ResultsThe 82.2% ultrasound tracking motion was within a 0.5 mm difference value between ultrasound tracking displacement and infrared monitoring motion. 0.7% ultrasound tracking failed to track accurately (a difference value &gt; 2.5 mm). These differences between ultrasound tracking motion and infrared monitored motion do not correlate with respiratory displacements, respiratory velocity, or respiratory acceleration by linear regression analysis.ConclusionsThe highly accurate monitoring results of this phantom study prove that the ultrasound tracking system may be a potential method for real-time monitoring targets, allowing more accurate delivery of radiation doses.
Development of the Simplified Chinese version of neonatal palliative care attitude scale
Authors: Zhong Yajing , Black Beth Perry , Kain Victoria J. , Sun Xiaoming , Song Yang 
Published: September 2022

BackgroundThe provision of palliative care for neonates who are not expected to survive has been slow in mainland China, and this model of care remains in its early stages. Evaluating nurses' attitudes toward neonatal palliative care (NPC) has the potential to provide valuable insight into barriers impeding NPC implementation. This study aimed to translate and adapt the traditional Chinese version of the Neonatal Palliative Care Attitude Scale (NiPCAS) into Simplified Chinese to assess its psychometric properties.MethodsThe NiPCAS is a valid and reliable instrument to measure nurses' attitudes for evidence-based practice. To date, the scale has not been used largely in mainland China. With translation and cultural adaptation, the traditional Chinese version of the NiPCAS was developed into a Simplified Chinese version. Its reliability was tested using internal consistency and test-retest reliability, and its validity was measured using the content validity index and exploratory factor analysis.ResultsA total of 595 neonatal nurses from mainland China were recruited. Twenty-six items in the scale were translated into Simplified Chinese. The scale demonstrated excellent reliability with a Cronbach's α coefficient of 0.87 and a test-retest reliability of 0.88. To support the Simplified Chinese version of NiPCAS, the scale content validity score was 0.98, and the exploratory factor analysis revealed five factors representing the conceptual dimensions of the scale.ConclusionThis study demonstrated the psychometric properties of the Simplified Chinese version of NiPCAS, validated its use as a viable tool for measuring neonatal nurses' attitudes toward NPC, and identified facilitators and barriers to NPC adoption. Our findings suggested supported clinical application in the context of mainland China. A confirmatory factor-analysis approach with a different sample of neonatal nurses is required for further testing of the instrument in the future.