bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Corticosteroids on the Proportions of Circulating Tfh Cell Subsets in Patients With Systemic Lupus Erythematous
Authors: Mao Minjing , Xu Shuqin , Lin Lin , Dong Danfeng , Xue Minghui , He Siwei , Cai Gang 
Published: July 2022

ObjectivesThis study aimed to analyze the distribution of T follicular helper (Tfh) cells in lupus patients, and the effects of steroids on circulating Tfh cells.MethodsCirculating Tfh cell subsets were defined by multicolor flow cytometry as Tfh17, Tfh2 or Tfh1 subpopulations of CXCR5+CD45RA–CD4+T cells in the peripheral blood of SLE patients and healthy controls. To test the effects of corticosteroid on Tfh cells, PBMC harvested from both SLE and healthy controls were cocultured with dexamethasone, and then analyzed by Flow cytometry.ResultsThe proportion of Tfh17 cells in SLE patients was increased significantly compared with healthy controls. Additionally, patients with an active disease had reduced Tfh1 subsets than those with an inactive disease and healthy controls. The frequency of Tfh2 cells was associated with the proportion of circulating plasmablasts and the amount of anti-dsDNA. Dexamethasone reduced the percentage of Tfh2 cells while increased the proportion of Tfh17 subset in gated CXCR5+CD45RA–CD4+T cells.ConclusionOur study investigated the distribution of circulating Tfh subsets in lupus patients. Corticosteroids treatment not only down-regulated the proportion of circulating Tfh cells, but also altered the distribution of Tfh subsetsin vivoandin vitro.
A Novel Systemic Inflammation Prognostic Score to Stratify Survival in Elderly Patients With Cancer
Authors: Ruan Guo-Tian , Xie Hai-Lun , Deng Li , Ge Yi-Zhong , Zhang Qi , Wang Zi-Wen , Zhang Xi , Zhang He-Yang , Tang Meng , Song Meng-Meng , Zhang Xiao-Wei , Yang Ming , Pan Lei , Wang Kun-Hua , Cong Ming-Hua , Gong Yi-Zhen , Wang Meng-Yan , Shi Han-Ping 
Published: July 2022

BackgroundElderly patients with cancer face the challenge of systemic inflammation, which can lead to a poor prognosis. Existing inflammatory indices cannot fully reflect the immune-inflammatory status of patients. This study aimed to develop a new scoring system to predict the survival of elderly patients with cancer using inflammatory indices, namely, the systemic inflammation prognostic score (SIPS).Materials and MethodsThis prospective multicenter study included a total of 1,767 patients with cancer, with a mean age of 70.97 ± 5.49 years, of whom 1,170 (66.2%) were men. We performed the least absolute shrinkage and selection operator (LASSO) regression to screen inflammatory indicators to include in constructing SIPS. Prognostic analysis of SIPS was performed using univariate and multivariate survival analyzes. The prognostic value of SIPS and its components were compared using the prognostic receiver operating characteristic curve and concordance index. The population was divided into the training cohort and the validation cohort in a 7:3 ratio and a SIPS prognostic analysis was performed.ResultsThe LASSO regression selected C-reactive protein (CRP) (≤ 9.81, “0”; &gt; 9.81, “1”), geriatric nutritional risk index (GNRI) (≤ 93.85, “1”; 93.85, “0”), advanced lung cancer inflammation index (ALI) (≤ 23.49, “1”; &gt; 23.49, “0”), and lymphocyte to C-reactive protein ratio (LCR) (≤ 2523.81, “1”; &gt; 2523.81, “0”) to develop SIPS. Patients were divided into the three groups based on the total SIPS: low-risk (0), moderate-risk (1–2), and high-risk (3–4). On the multivariate survival analysis, patients in the moderate-risk [P &lt; 0.001, hazard ratio (HR) = 1.79, 95% CI: 1.47–2.17] and high-risk groups (P &lt; 0.001, HR = 2.40, 95% CI: 1.98–2.92) showed a worse prognosis than those in the low-risk group. The total cohort, training cohort, and validation cohort all showed that SIPS had better survival prediction than CRP, GNRI, ALI, and LCR. The HRs were 2.81 times higher in patients in the high-risk group with malnutrition than in patients in the low-risk group without malnutrition.ConclusionSIPS was an independent prognostic indicator in elderly patients with cancer. Malnutrition in the high-risk group increased the mortality risk.
Quartz Tube Enhanced Raman Scattering Spectroscopy
Authors: Si Ganshang , Liu Jiaxiang , Li Zhengang , Ning Zhiqiang , Fang Yonghua 
Published: July 2022

Raman spectroscopy is widely used in many fields with the advantages of simultaneous species detection and molecular fingerprint characteristics, but the low detection sensitivity limits its further development, especially for highly scattering or turbid mediums. In this consideration, a new method called quartz tube enhanced Raman scattering spectroscopy was proposed for the first time in this paper. A quartz tube was inserted into the powder sample to improve the coupling of light into the medium and increase the interaction volume of the laser with the sample (“volume-excitation”), multiple scattering of the light within the turbid medium resulted in an increased Raman signal. In this paper, the effect of different sizes of quartz tubes on the sensitivity enhancement was studied. The results show that the enhancement factor of the signal intensity was nearly 5.37 (the Raman signal of HCO3−) compared to traditional Raman spectroscopy technology. Furthermore, the method was successfully applied to improve the Raman signal intensity of the mixed sample (1:5, m (PO43−):m (HCO3−)) and detect the baking soda powder buried under a 6 mm thick layer of potassium dihydrogen phosphate powder. The results show that the technology will open a new way for the quantitative analysis and detection of powder samples.
Parameters for Change in Offline Gambling Behavior After the First COVID-19 Lockdown in Germany
Authors: Kalke Jens , Schütze Christian , Lahusen Harald , Buth Sven 
Published: July 2022

IntroductionIn spring 2020, the first nationwide lockdown in response to the spreading COVID-19 pandemic came into effect in Germany. From March to May, gambling venues, casinos, and betting offices were forced to close. This study explores how land-based gamblers respond to short-term closures of higher-risk forms of gambling. Which gamblers are particularly susceptible to switching to online gambling? Which are more likely to use the lockdown as an opportunity to quit or pause gambling? Potential parameters for these switching or cessation processes are identified using multivariate multinomial logistic regression analysis.MethodsThe research questions are analyzed on the basis of quantitative data. For this purpose, a survey was conducted among members of a comparatively large German online access panel (“PAYBACK panel”). The sample of analysis consisted of 612 gamblers who had participated in at least one higher-risk form of gambling and had done so exclusively offline before the first lockdown (January and February 2020).ResultsA total of 37.1% of sports bettors ceased participation in higher-risk forms of gambling, compared to 64.1% of casino gamblers. Switching to online gambling, on the other hand, was a rather rare event, regardless of the form of gambling: the proportions differ between 7.7% (slot machines) and 10.9% (sports betting). In the multivariate model female gender, younger age, and a lower frequency of gambling before the first lockdown were found to be significant factors for quitting (instead of continuing) higher-risk offline gambling forms. Secondly, the analysis revealed that individuals with more pronounced cognitive distortions had an increased risk of switching to online gambling rather than staying offline.DiscussionA key finding of this study is that the temporary closure of offline venues does not result in a significant shift towards the online market. Instead, the results of this study show that these short, temporary closures of gambling venues were an appropriate opportunity to give individual groups of gamblers the opportunity to reflect, reduce or quit gambling. It is worth considering implementing such temporary closures as a preventive measure in the future – this should be investigated in advance in further evaluation studies.
A Novel Prognostic Signature Associated with Immunotherapeutic Response for Hepatocellular Carcinoma
Authors: Jin Xinmin , Wang Jinhuan 
Published: July 2022

BackgroundAlthough accumulating literature has validated that necroptosis plays a prominent role in the tumorigenesis and progression of various malignant cancer, its mechanism in hepatocellular carcinoma (HCC) is poorly understood. Therefore, in the present study, we want to study the impact of necroptosis-related genes on the prognosis and microenvironment-infiltrating immunocytes and the effect of immunotherapy on patients with HCC.MethodsThe necroptosis-related genes were obtained by reviewing the available published literature; we then evaluated the effects of the prognostic genes on the relative abundance of microenvironment infiltrated immunocytes. After construction of the Risk Score Signature, we evaluated the prognostic value and the effects on immune cells infiltrating the tumor microenvironment (TME). Combining the available data on immunotherapy, we also investigated the impact on anti-PD-L1-based immunotherapy.ResultsA comprehensive study of the published literature confirmed that 22 genes are related to necroptosis. Among them, 10 genes were related to the prognosis of the HCC cohort in The Cancer Genome Atlas (TCGA) and had a multifaceted influence on TME. We obtained the Risk Score Signature by Lasso regression. Furthermore, we also corroborated the correlation between the Risk Score Signature and tumor-infiltrating immune cells in the TME. Next, in the study of the correlation between the Signature and immunotherapy, we found that the Signature was significantly correlated with the reactivity of anti-PD-L1 immunotherapy. We also confirmed that the Risk Score Signature is a reliable and efficient independent prognostic marker of HCC.ConclusionWe established a novel and effective prognostic model for patients with HCC, which is markedly related to the TME and immune infiltration in HCC and can also predict immunotherapeutic response and prognosis.
The Real-World Impact of Vaccination on COVID-19 Cases During Europe’s Fourth Wave
Authors: Jain Vageesh , Serisier Aimee , Lorgelly Paula 
Published: July 2022

Objectives: Disease control is important to limit the social, economic and health effects of COVID-19 and reduce the risk of novel variants emerging. Evidence suggests vaccines are less effective against the Omicron variant, but their impact on disease control is unclear.Methods: We used a longitudinal fixed effects Poisson regression model to assess the impact of vaccination on COVID-19 case rates across 32 countries in Europe from 13th October to 01st January 2022. We controlled for country and time fixed effects and the severity of public health restrictions.Results: Full vaccination coverage increased by 4.2%, leading to a 54% reduction in case rates across Europe (p &lt; 0.001). This protection decreased over time but remained significant at 5 weeks after the detection of Omicron. Mean booster vaccination rates increased from 2.71% to 24.5% but provided no significant additional benefit. For every one-unit increase in the severity of public health restrictions, case rates fell by a further 2% (p = 0.019).Conclusion: Full vaccination significantly limited the spread of COVID-19 and blunted the impact of the Omicron variant, despite becoming less useful over time.
Pengaruh Good Corporate Social Responsibilit (CSR), Return On Assets (ROA), Return On Equity (ROE), Debt To Equity Ratio (DER) terhadap Nilai Perusahaan (Study Empiris Perusahaan yang Tercatat di LQ45 Periode 2016-2018)
Authors: Pranita Fera Lufhidarani 
Published: July 2022

<p>Penelitian ini bertujuan untuk menganalisis dan mengetahui pengaruh <em>Corporate Social Responsibility </em>(CSR), <em>Return On Asset</em> (ROA), <em>Return On Equity (ROE)</em> dan <em>Debt to Equity Ratio</em> (DER) terhadap Nilai Perusahaan,pada perusahaan yang tercatat di LQ45 periode 2016-2018. Metode pendekatan Analisis Regresi Linear Berganda dengan menggunakan metode kuantitatif untuk mengetahui apakah terdapat pengaruh yang signifikan antara variable terhadap Nilai Perusahaan,pada perusahaan yang tercatat di LQ45 periode 2016-2018. Sampel dalam penelitian ini diambil melalui kriteria purposive sampling sehingga didapatakan sebanyah 28 Perusahaan yang memenuhi kriteria dari 45 perusahaan yang tercatat di LQ45 pada periode 2016-2018. Dari hasil penelitian yang diperoleh bahwa secara parsial CSR berpengaruh negative terhadap Nilai Perusahaan, Perusahaan dengan pengungkapan CSR yang tinggi akan berakibat pada tingginya beban yang harus dikeluarkan perusahaan untuk melakukan kegiatan CSR tersebut, sehingga akan berdampak pada berkurangnya laba yang diperoleh perusahaan dan akan berdampak pada penurunan nilai perusahaan. ROA (Return on Asset) yang diperoleh perusahaan akan berpengaruh terhadap nilai perusahaan dimana semakin tinggi keuntungandari asset perusahaan akan mempengaruhi pula laba yang diperoleh perusahaan begitu pula dengan ROE rasio rentabilitas modal sendiri yang tinggi menandakan tingginya keberhasilan pucuk pimpinan perusahaan dalam mengemban misi dari pemiliknya. serta DER dimana Konsep <em>leverage </em>ini penting bagi investor dalam membuat pertimbangan penilaian saham. Para investor umumnya cenderung menghindari risiko. Risiko yang timbul dalam penggunaan <em>financial leverage </em>disebut dengan <em>financial risk </em>yaitu risiko tambahan yang dibebankan kepada pemegang saham sebagai hasil penggunaan utang oleh perusahaan. Semakin tinggi leverage, semakin besar risiko keuangannya dan sebaliknya.</p>
Defeito do septo ventricular em cães e gatos, uma revisão / Ventricular septal defect in dogs and cats, a review
Authors: Sartorelli Matheus de Moraes , Kerchener Alice , Moraes Júlia Vulpini de , Feder Gabriela , Vanzella Luiza 
Published: July 2022

O defeito do septo ventricular (DSV) tem origem no desenvolvimento incompleto ou no desalinhamento do septo interventricular (SIV) ainda durante o estágio embrionário, de forma congênita. Anatomicamente, o DSV define-se por orifícios de números, tamanhos e formas variadas no SIV, estando, por vezes, associado a outros defeitos cardíacos. Quanto à prevalência, encontra-se com maior frequência em Buldogues ingleses e, em relação à anatomia, tem maior ocorrência na região membranosa do septo interventricular, muitas vezes ocasionando em defeitos perimembranosos. A comunicação interventricular desenvolve-se levando a um desvio intracardíaco da esquerda para a direita devido aos níveis de maior pressão sistólica e, quando ao contrário - da direita para a esquerda - resulta em cianose, quadro sugestivo de desvios mais graves. Pequenos DSVs não resultam em sinais clínicos, entretanto, predispõem a endocardite frequentemente, além do fechamento espontâneo dos orifícios ser raro em cães e gatos. O DSV pode ainda ocasionar em regurgitação da aorta com prolapso diastólico dos folhetos valvares, devido à irrigação inadequada da artéria. Clinicamente, a maioria dos casos são assintomáticos e, quando sintomáticos, manifestam-se frequentemente através da intolerância ao exercício, tosse, dispneia e por meio de sinais da Insuficiência Cardíaca Congestiva (ICC) esquerda. O aumento da velocidade do fluxo e da turbulência nos orifícios do SIV causam sopro holossistólico, mais reconhecível no hemitórax direito. O diagnóstico associa fatores como histórico, sinais clínicos, exame físico e, precisamente, a ecoDopplercardiografia onde averígua-se o fluxo do desvio do DSV. O tratamento engloba a oclusão cirúrgica de peito aberto e os métodos transcateteres com uso de oclusores. De forma paliativa se considera como tratamento, em casos específicos, a colocação cirúrgica de bandagem constritiva em torno do tronco pulmonar.
Comportamiento productivo de búfalas lecheras (Bubalus bubalis) en la provincia Granma, Cuba / Productive performance of dairy buffaloes (Bubalus bubalis) in Granma province, Cuba
Authors: Pérez Yankiel Enrique Ramírez , Reyes Bánier Ramírez , Núñez Yosbany Espinosa , Borroto Odilia Gutiérrez 
Published: July 2022

La ganadería bubalina forma parte de una estrategia económica del país, conocer esta especie es de gran utilidad por su aporte a la alimentación humana. El objetivo de esta investigación fue caracterizar el comportamiento productivo de búfalas lecheras en la Empresa Agropecuaria Bayamo, provincia de Granma, con promedios mensuales de precipitaciones en el orden de 608,5 a 1264,9 mm3. Para ello, se utilizaron datos contenidos en tarjetas individuales de 125 reproductoras en el período 2011-2015. Para modelar la curva de producción se aplicaron las funciones cuadrática logarítmica y exponencial a 592 pesajes de 96 búfalas de río. La organización, descripción y procesamiento de datos se realizó con los sistemas Microsoft Excel y SPSS versión 22. Para cada indicador se obtuvo la media, desviación estándar, y coeficiente de variación. El rebaño concentró el 78,54% de los nacimientos entre Agosto y Noviembre, la edad de incorporación fue 27,85±2,19 meses, y condicionó retrasos en la edad al primer parto con 38,81±4,95 meses, la edad promedio del rebaño e intervalo entre partos fueron de 8,85 años y 385,04 días respetivamente. El porciento de búfalas en ordeño incrementó de 61,83% en el primer año, hasta 92,83% en el último. El rendimiento lechero osciló entre 6,32 ± 2,30 a 1,83 ± 1,52 kg/d. Se concluyó que las búfalas muestran una estacionalidad reproductiva asociada al régimen de lluvias y la disponibilidad de alimento, ubicando la época de partos entre los meses de agosto a noviembre, como consecuencia los niveles productivos se elevan en el periodo poco lluvioso. La función que mejor describió la curva de producción fue la cuadrática logarítmica con una curva típica para producción de leche en pastoreo, que evidenció un crecimiento inicial seguido de un pico discreto y una fase decreciente pronunciada.
Propagación de estacas de morera (Morus alba L.) en condiciones de invernadero: comunicación / Vegetative propagation of mulberry cuttings (Morus alba L.), in greenhouse conditions: communication
Authors: Villalta-Zúñiga Oscar Néstor , Elizondo-Salazar Jorge Alberto , Russo Ricardo O. 
Published: July 2022

Introducción. Durante la alimentación de vacas lecheras Jersey, con ramas de morera (Morus alba L.), ofrecidas en las canoas, en la Estación Experimental Alfredo Volio Mata (EEAVM), queda un residuo de ramas defoliadas, con la corteza intacta, que son desechadas. Objetivo. Evaluar la viabilidad de propagación vegetativa y longitud apropiada de estacas de morera, provenientes de ramas defoliadas durante la alimentación de vacas lecheras. Materiales y métodos. El experimento se desarrolló en el invernadero de la EEAVM, de agosto hasta octubre de 2019, durante diez semanas. El delineamiento estadístico utilizado fue experimento de comparación simple, con diez repeticiones. Los tratamientos correspondieron a cinco longitudes de estaca (15, 20, 25, 30, 50 cm). Cada estaca se plantó en una bolsa plástica con un sustrato de compost. Resultados y Conclusiones. La propagación vegetativa de estacas de ramas de morera remanente fue viable en las condiciones del invernadero y se encontró que la longitud más apropiada fue de 25 a 30 cm; con 70 a 80 porciento de estacas brotadas y entre 3 y 4 ramas por estaca.
Program Sosialisasi Dan Aksi Pencegahan Covid-19 Pada Masyarakat Desa Jonggol Jambon Ponorogo
Authors: Yuniyanti Risma Faizah , Ilma Mughniatul 
Published: July 2022

Munculnnya klasifikasi Virus Corona atau Covid-19 yang telah menyebar hingga seluruh belahan bumi tidak terkecuali dengan negara Indonesia yang juga menghadapi masalah tersebut baik provinsi, ibukota, dan kabupaten ikut merasakan dampak negatif dari virus Corona.Virus tersebut mampu bermutasi menjadi varian virus baru. Maka dari itu penulis melakukan program sosialisasi dan aksi pencegahan covid-19 dan tujuan dari kegiatan Kuliah Pengabdian Masyarakat (KPM) adalah membantu dan memberikan edukasi sosalisasi atau pemahaman mengenai pentingnya menerapkan protocol kesehatan pada sisuasi pandemi Covid-19. Diharapkan dengan adanya program tersebut masyarakat akan lebih sadar dan mampu menaati himbauan kesehatan yang telah dianjurkan dengan sikap yang disiplin dan penuh tanggung jawab. Kegiatan tersebut menggunakan 5 tahapan yaitu melalui metode penyelesaian ABCD (Asset, Based, Community Development) yang telah digunakan untuk mengajak mitra masyarakat atau remaja di Desa Jonggol, Kecamatan Jambon Kabupaten Ponorogo untuk memanfaatkan potensi kesehatan yang telah mereka miliki. Hasil yang telah di capai dari pengabdian masyarakat tersebut adalah (1) meningkatnya pengetahuan dan wawasan masyarakat tentang pentingnya mematuhi protokol kesehatan, (2) masyarakat memiliki kesadaran yang tinggi tentang bahaya Covid-19, (3) masyarakat mampu menerapkan pola hidup yang sehat. Program tersebut di harapkan dapat bersifat secara berkelanjutan pada masyarakat dan memberikan banyak manfaat dan dapat terhindar dari virus Covid-19.
Israi’liyat Materials in Tafsir al-Thabari
Authors: Jali Nafisah 
Published: July 2022

Israi’liyat is a story that comes from Jews and Christians or interpretations that have no basis at all, either in the form of dhaif and maudu’ traditions, false ta’wil, or fantasies of contemporary commentators that are deliberately inserted into the interpretation. There are 38,397 narrations as a source of interpretation of Ma’tsur written by Ibn Jarir al-Thabari in his commentary, the history of Ma’tsur is based on the opinions and views of the companions and tabi’in. This research method uses a descriptive analysis method in which the author explains Israi’liyat in his commentary book Ibn Jarir al-Thabari and analyzes the sources of Israi’liyat interpretation contained in the book of al-Thabari’s interpretation. The results of this study are that after being analyzed, it turns out that the author found several narrations of Israi’liyat in a Thabari’s interpretation which was used as one of the sources of interpretation that Ibn Jarir al-Thabari used. The history of Israi’liyat is in accordance with Islamic teachings, some are not in accordance with Islamic teachings and Mauquf Israiliyat.
Steady-state voltage modelling (air over-stoichiometry dependent) of a HT-PEMFC under various operating conditions
Authors: Rigal Sylvain 
Published: July 2022

<p>Research paper. Abstract : In this work, a commercially available Membrane Electrode Assembly from Advent Technology Inc., developed for a use in High Temperature Proton Exchange Membrane Fuel Cell, was tested under various Operating Conditions (OCs) according to a sensibility study with three OCs varying on three levels: hydrogen gas over-stoichiometry (1.05, 1.2, 1.35), air gas over-stoichiometry (1.5, 2, 2.5) and temperature (140°C, 160°C, 180°C). A polarization curve (V-I curve) was performed for each set of operating conditions (27 V-I curves in total). A semi-empirical and macroscopic (1D) model of the cell voltage was developed in steady state conditions to model these experimental data. With the proposed parameterization approach, only one set of parameters is used in order to model all the experimental curves (simultaneous optimization with 27 curves). Thus, an air over-stoichiometry dependent model was developed. The obtained results are satisfying between 0.2 and 0.8 A.cm-²: an average error less than 1.5 % and a maximum error around 7 % between modelled and measured voltages with only 9 parameters to identify. The obtained parameters appear consistent regardless the OCs. The proposed approach with only one set of parameters seems to be an interesting way to converge towards a uniqueness of consistent parameters. </p>