bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness and use of avalanche airbags in mortality reduction among winter-recreationists
Authors: Di Stefano Lucia Laura , Della Libera Bianca , Rodi Paolo 
Published: November 2022

Abstract

Background/objective
The number of backcountry skiers and snowboarder surged in the last years, especially during the COVID-19 pandemic, as ski resorts shut down. Inevitably, this led to an increase in avalanche-related injuries and death. As avalanche rescue device, avalanche airbags are increasingly becoming part of the standard winter mountaineering equipment. This study provides a review of the available data and an updated perspective on avalanche airbags, discussing their function and efficacy to reduce mortality and their limitations.

Results
Causes of death in individuals caught by avalanches are multiple. Airbags seem to reduce mortality by decreasing the chances of critical burial, the most determining risk factor. However, there is a scarcity of reliable scientific research on the topic, and the way in which airbags reduce mortality and to what extent is still debated. Several elements seem to influence airbags efficacy, and their use still yields several limitations linked to manufacturing, proper use, users education and risk compensation.

Conclusions
Avalanche airbags seem to be an important tool in reducing mortality in the backcountry expeditions. However, more research and standardized data collection are needed to fill the knowledge gap, and mountain communities should promote adequate education of winter-recreationists on how to prevent and react to an avalanche and on the correct use of airbags in combination with already available tools such as transceivers, probes and shovels; and manufacturing companies should ensure higher efficacy of the survival avalanche equipment for better prevention of burial, asphyxia and trauma.
Drought response in Arabidopsis displays synergistic coordination between stems and leaves
Authors: Thonglim Ajaree , Bortolami Giovanni , Delzon Sylvain , Larter Maximilian , Offringa Remko , Keurentjes Joost J B , Smets Erik , Balazadeh Salma , Lens Frederic 
Published: November 2022

AbstractThe synergy between drought-responsive traits across different organs is crucial in the whole-plant mechanism influencing drought resilience. These organ interactions, however, are poorly understood, limiting our understanding of drought response strategies at the whole-plant level. Therefore, we need more integrative studies, especially on herbaceous species that represent many important food crops but remain underexplored in their drought response. We investigated inflorescence stems and rosette leaves of six Arabidopsis thaliana genotypes with contrasting drought tolerance, and combined anatomical observations with hydraulic measurements and gene expression studies to assess differences in drought response. The soc1ful double mutant was the most drought-tolerant genotype based on its synergistic combination of low stomatal conductance, largest stomatal safety margin, more stable leaf water potential during non-watering, reduced transcript levels of drought stress marker genes, and reduced loss of chlorophyll content in leaves, in combination with stems showing the highest embolism resistance, most pronounced lignification, and thickest intervessel pit membranes. In contrast, the most sensitive Cvi ecotype shows the opposite extreme of the same set of traits. The remaining four genotypes show variations in this drought syndrome. Our results reveal that anatomical, ecophysiological, and molecular adaptations across organs are intertwined, and multiple (differentially combined) strategies can be applied to acquire a certain level of drought tolerance.
Self-consistent nanoflare heating in model active regions: MHD avalanches
Authors: Reid J , Threlfall J , Hood A W 
Published: November 2022

ABSTRACT
Straightened cylindrical models of coronal loops have been standard for decades, and shown to support nanoflare-like heating, but the influence of geometric curvature in models upon the heating produced has not been discussed in depth. Heating, its spatiotemporal distributions, and the associated mechanisms responsible are discussed, and compared with those from straightened models of a coronal loop. Previously, magnetohydrodynamic avalanches have been generalized to curved loops, and shown to be viable. From that study, the associated heating is analysed and discussed in depth. Heating is seen to arise from processes originally instigated, yet not dominated, by magnetic reconnection, producing bursty, aperiodic nanoflares, dispersed evenly throughout the corona, but with a modest bias away from footpoints. One novelty arising is the simultaneous yet independent occurrence of nanoflare-like events at disjoint sites along individual strands, anticipating some features recently seen in ‘campfires’ by Solar Orbiter. With a view to future refinements in the model and to the inclusion of additional physical effects, the implications of this analysis are discussed.
Assessment of the distribution of Ruditapes spp. in northern Mediterranean sites using morphological and genetic data
Authors: Mahé Mathilde , Aurelle Didier , Poggiale Jean Christophe , Mayot Nicolas 
Published: November 2022

ABSTRACT
In the 1970s, Ruditapes philippinarum was introduced to France at Arcachon Bay for aquaculture. At present, in Europe, R. philippinarum is often found in place of the native species Ruditapes decussatus. The aim of this study is to evaluate the distribution of these two species along the northern Mediterranean coastline using morphological and morphometric analysis. The sampling period was between June and December 2018. Among the 11 French sites, only 2 contained R. philippinarum, whereas only the indigenous species was present at the other sites. Genetic analyses were used to confirm species identity and to confirm this distribution. A site in Italy, Pialassa Baiona, was also added to the sample. This analysis of Ruditapes from multiple French sites and one Italian site highlights species-level differences in shell morphology between R. decussatus and R. philippinarum. The intraspecific morphometric analysis showed the presence of different groups depending on spatial scales (i.e. at the large scale, between the Mediterranean Sea and the Atlantic, and on the small scale, that is within the Berre lagoon in France. No relationship between morphometric and genetic variation was found. This suggests that the differences in the shell shape of Ruditapes are driven by local environmental conditions.
Routine Donor and Recipient Screening for Mycoplasma hominis and Ureaplasma Species in Lung Transplant Recipients
Authors: Vijayvargiya Prakhar , Esquer Garrigos Zerelda , Kennedy Cassie C , Daly Richard C , Wylam Mark E , Patel Robin , Beam Elena 
Published: November 2022

Abstract

Background
Mycoplasma hominis, Ureaplasma urealyticum, and Ureaplasma parvum may cause post-transplant infections in lung transplant recipients. We evaluated routine pretransplant screening for these Mollicutes.

Methods
We retrospectively reviewed records of lung transplant recipients at our tri-site institution from 01/01/2015 to 11/15/2019. M. hominis and/or Ureaplasma polymerase chain reaction (PCR) was performed on pretransplant recipient urine specimens and donor bronchial swabs at the time of transplantation. Development of Mollicute infection and hyperammonemia syndrome (HS) was recorded.

Results
A total of 268 patients underwent lung transplantation during the study period, of whom 105 were screened with at least 1 Mollicute PCR. Twelve (11%) screened positive; 10 donors, 1 recipient, and 1 both. Among positive donors, 3 were positive for M. hominis, 5 for U. urealyticum, and 4 for U. parvum. Preemptive therapy included doxycycline, levofloxacin, and/or azithromycin administered for 1–12 weeks. Despite therapy, 1 case of M. hominis mediastinitis and 1 case of HS associated with Ureaplasma infection occurred, both donor-derived. Of those screened before transplant, cases with positive screening were more likely (P &lt; 0.05) to develop Mollicute infection despite treatment (2/12, 17%) than those who screened negative (1/93, 1%).

Conclusions
Pretransplant recipient urine screening had a low yield and was not correlated with post-transplant Mollicute infection, likely because most M. hominis and U. parvum/urealyticum infections in lung transplant recipients are donor-derived. Routine donor bronchus swab PCR for M. hominis, U. urealyticum, and U. parvum followed by preemptive therapy did not obviously impact the overall incidence of Mollicute infection or HS in this cohort.
A Systematic Review of Decision Aids in Hematologic Malignancies: What Are Currently Available and What Are We Missing?
Authors: Zhao Janice , Abdallah Maya , Sanapala Chandrika , Watson Erin , LoCastro Marissa , Castillo Daniel A , Richardson Daniel , LeBlanc Thomas W , Loh Kah Poh 
Published: November 2022

AbstractBackgroundPatient decision aids (PDAs) are tools designed to facilitate decision-making. In this systematic review, we summarized existing studies on the development and evaluation of PDAs for patients with hematologic malignancies.Patients and MethodsWe followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched for articles in PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov. We included studies, abstracts, and clinical trial protocols available in English involving PDAs for patients age ≥18 diagnosed with a hematologic malignancy and/or their caregivers. Data were summarized using descriptive statistics.ResultsOf the 5281 titles/abstracts screened, 15 were included: 1 protocol, 7 abstracts, and 7 full-texts. Six were PDA developmental studies, 6 were pilot studies, and 3 were randomized trials. PDA formats included electronic with web content, videos, and/or audio, questionnaires, bedside instruments, and a combination of various formats. Average participant age ranged from 36.0 to 62.4 years. Patients and caregivers identified efficacy, adverse effects, cost, and quality of life as important decision-making factors. PDAs were associated with increased knowledge and patient satisfaction as well as decreased decisional conflict and attitudinal barriers. Research on PDAs for adult patients with hematologic malignancies and their caregivers is limited. Among the studies, PDAs appear to support patients in shared decision-making.ConclusionWhile current literature examining the use of PDAs for adults with hematologic malignancies is limited, the positive impact of PDAs on shared decision-making and patient outcomes warrants additional research in this field.
Structural insight into the activation of an Arabidopsis organellar C-to-U RNA editing enzyme by active site complementation
Authors: Toma-Fukai Sachiko , Sawada Yuto , Maeda Ayako , Shimizu Hikaru , Shikanai Toshiharu , Takenaka Mizuki , Shimizu Toshiyuki 
Published: November 2022

Abstract
RNA-binding pentatricopeptide repeat (PPR) proteins catalyze hundreds of cytidine to uridine RNA editing events in plant organelles; these editing events are essential for proper gene expression. More than half of the PPR-type RNA editing factors, however, lack the DYW cytidine deaminase domain. Genetic analyses have suggested that their cytidine deaminase activity arises by association with a family of DYW1-like proteins that contain an N-terminally truncated DYW domain, but their molecular mechanism has been unclear. Here, we report the crystal structure of the Arabidopsis thaliana DYW1 deaminase domain at 1.8 Å resolution. DYW1 has a cytidine deaminase fold lacking the PG box. The internal insertion within the deaminase fold shows an α-helical fold instead of the β-finger reported for the gating domain of the A. thaliana ORGANELLE TRANSCRIPT PROCESSING 86. The substrate-binding pocket is incompletely formed and appears to be complemented in the complex by the E2 domain and the PG box of the interacting PPR protein. In vivo RNA editing assays corroborate the activation model for DYW1 deaminase. Our study demonstrates the common activation mechanism of the DYW1-like proteins by molecular complementation of the DYW domain and reconstitution of the substrate-binding pocket.
Differences in healthy lifestyle habits in university students as a function of academic area
Authors: García-Pérez Laura , Villodres Gracia Cristina , Muros José Joaquín 
Published: November 2022

AbstractBackgroundIt is known that the promotion and acquisition of healthy attitudes is a key factor depending on the academic training provided by the university studies on which students are enrolled.The aim of the present research is to analyse and compare lifestyle habits and health-related quality of life (HRQoL) as a function of academic training.MethodsA cross-sectional study with a volunteer convenience sample of 707 undergraduate participants aged (21.98 ± 3.50 years). Students were divided into four different groups according to their area of academic training. Socio-demographic variables, adherence to the Mediterranean diet (MD), physical activity (PA) engagement and HRQoL were recorded.ResultsPA and sport science students reported better scores in PA (6342.39 ± 2313.99 metabolic equivalents [METs]; P = 0.000), MD adherence (6.33 ± 2.69; P = 0.000) and HRQoL in physical and mental health (MH; 54.85 ± 9.18; 53.70 ± 13.6; P = 0.000). In contrast, non-health-related sciences (NHRS) students reported the lowest scores on assessed items. Students with a medium/high monthly salary reported better MD adherence (6.16 ± 3.07; P = 0.012). In addition, females reported better scores (6.41 ± 2.65; P = 0.000) than males. Further, males indicated better perceptions of MH (46.52 ± 18.84; P = 0.014). Moreover, university students with a high level of MD adherence were revealed to engage in more PA (5181.17 ± 2813.35 METs; P = 0.000) and have better HRQoL with regards to both physical (54.76 ± 8.84; P = 0.000) and MH (48.11 ± 16.73; P = 0.000).ConclusionsOutcomes point to differences in MD adherence, PA and HRQoL according to academic training. NHRS students who did not know healthy habits reported lower scores for all studied items. This indicates the need for health interventions at universities.
Risk-Taking and Asymmetric Learning in Boom and Bust Markets
Authors: Kieren Pascal , Müller-Dethard Jan , Weber Martin 
Published: November 2022

Abstract
An increasing number of studies depart from the rational expectations assumption to reconcile survey expectations with asset prices. While surveys are helpful to establish a link between subjective beliefs and investment decisions, precise inference about how investors depart from rational expectations can be challenging without relying on strong assumptions. In this article, we provide direct experimental evidence of how systematic distortions in investors’ expectations affect their risk-taking across market cycles. As mechanism, we identify an asymmetry in how individuals update their expectations across boom and bust markets. The documented mechanism is consistent with survey data and provides important implications for recently proposed asset pricing models.
Doing Intimacy in Pandemic Times: Findings of a Large-Scale Survey Among Singles in Japan
Authors: KOTTMANN Nora , DALES Laura 
Published: November 2022

Abstract
Singles—here understood as unmarried or never married individuals—are a growing subset of the Japanese population that has not received discrete attention in the context of the COVID-19 pandemic. This article addresses the ways in which the pandemic and its associated interventions—calls for social distancing, self-restraint, or the avoidance of the ‘3Cs’—affect singles’ (non)familial personal relationships and practices of intimacy (platonic and romantic), as well as perceptions of singlehood and ‘solo activities’ (sorokatsu). Based on exploratory analyses of data from an original cross-sectional online survey conducted in early 2021 (n = 4.000; unmarried residents of Japan aged 25–49 years), we show that while practices of intimacy are changing throughout the pandemic, the changes are less dramatic than we anticipated. In addition, changes are highly gendered and seem to support contemporary media and public discourse on how individuals are managing COVID-life and its concomitant uncertainties. We see two diachronic developments: an increase in social isolation and distress on the one hand, and an increase in acceptance of being single and doing ‘solo activities’ on the other. Our findings contribute to an understanding of the ways that singlehood, marital status, and extra-familial relationships are shaped, and shape the experiences of this pandemic.
Cardiac surgery, ICU sedation, and delirium: is dexmedetomidine the silver bullet?
Authors: Smith Wendy , Whitlock Elizabeth L. 
Published: November 2022

Purpose of review
Delirium is a marker of acute brain insufficiency and a harbinger of poor outcomes and increased healthcare costs. Despite success preventing delirium by nonpharmacologic measures, the incidence in the postcardiac surgical ICU population remains high. Dexmedetomidine, a selective alpha-2 agonist, is a plausible preventive agent with sedative, anxiolytic, analgesic, sympatholytic and anti-inflammatory properties, and is the subject of very active study in cardiac surgery populations.

Recent findings
Recent trials, including DEXACET (2019), DECADE (2020), LOWDEXDEL (2021), and DIRECT (2022) individually, failed to show a benefit for dexmedetomidine and highlighted associated risks. Meta-analyses have offered conflicting results, highlighting the complexity of delirium, and likely interaction of multiple etiological pathways; those that concluded benefit often were driven by trials at high risk of bias. Meta-analyses excluding biased trials currently suggest no benefit for dexmedetomidine over control in unselected cardiac surgical populations.

Summary
Although using dexmedetomidine to prevent delirium in unselected cardiac surgical patients is not supported by current evidence, there remains hope that it may offer benefits in highly selected populations, and further trials are ongoing.
Distress Tolerance in the Comorbid Chronic Pain and Opioid Use Disorder Population
Authors: Wilson Sarah C. , Shaffer Jonathan A. , Wachholtz Amy B. 
Published: November 2022

Objectives
The risk of opioid addiction among people with chronic pain is elevated in those using opioids to self-medicate physical or emotional pain or distress. The purpose of this study is to test the main effect of distress tolerance (DT) on opioid use disorder (OUD) status in people with chronic pain, and the potential moderating effect of DT in the relationship between known addiction risk factors and the development of OUD.

Methods
One hundred twenty people with chronic pain were recruited to 1 of 3 groups according to their opioid use status (ie, current methadone or buprenorphine/naloxone for OUD [n = 60], history of OUD but current prolonged opioid abstinence [n = 30, meanabstinence = 121 weeks, SD = 23.3], and opioid naive [n = 30]). Participants completed self-report measures and a cold pressor task. Multinomial logistic regression analyses were used to test if DT associated with OUD status in people with chronic pain and to compare DT to other known indicators of OUD risk. Multinomial linear regression analyses were used to test the moderation effects of DT on the relationship between various risk factors and OUD in people with chronic pain.

Results
Analyses revealed that DT was significantly related to OUD status but did not moderate the effects of most OUD risk factors.

Conclusions
These results suggest that decreasing distress (eg, pain levels, craving responses, etc) may be more effective than improving tolerance to distress for the comorbid chronic pain and OUD population.
Renal arterial embolization: Indications, angiographic findings, and outcomes in a series of 170 patients
Authors: Farg Hashim Mohamed , Elawdy Mohamed , Soliman Karim Ali , Badawy Mohamed Ali , Elsorougy Ali , Mohsen Tarek , El-Diasty Tarek , Abdelhamid Abdalla 
Published: November 2022

Abstract

Background
The lack of overall experience and reporting on angiographic findings in previously published studies of renal arterial embolization (RAE) compelled us to report our overall experience on a series of patients.

Materials and methods
A retrospective study was performed analyzing data of patients enrolled for RAE between 2010 and 2019. History, physical examination, and laboratory data were reviewed for all patients. Abdominal ultrasound was the initial imaging study, and all patients underwent subsequent computed tomography or magnetic resonance imaging. The outcome of RAE was determined based on radiographic and clinical findings.

Results
Data from 202 patients were analyzed, with a mean age of 45 ± 15 years, and 71.3% of patients were male. Iatrogenic injury was the most common indication for RAE (54%), followed by renal tumors, trauma, and spontaneous, in 27.7%, 10.4%, and 8.4% of patients, respectively. Renal angiography revealing pseudoaneurysm alone or with other pathology in the lower pole of the kidney was the most common finding (40.6%), whereas no lesions were identified on angiography in 32 patients (15.8%), after which RAE was subsequently aborted. Renal arterial embolization was successful in 158 of 170 patients (92.9%) after 1 or more trials (maximum of 4). Microcoil alone or with other embolic materials was the most commonly used material for embolization (85%).

Conclusions
Iatrogenic injury was the most common indication for RAE. Pseudoaneurysm alone or with other lesions was the most common lesion on renal angiography; however, angiography showed a negative result in 16% of patients, even those with symptoms. When lesions are present on angiography, the overall success of repeated trials of RAE reached 92.9%.