bluuebunny/crossref_metadata_2025_split huggingface dataset:
Previous Functional Social and Behavioral Rhythms Affect Resilience to Covid-19-Related Stress among Old Adults
Authors: Carta Mauro Giovanni , Fornaro Michele , Minerba Luigi , Pau Massimiliano , Velluzzi Fernanda , Atzori Laura , Aviles Gonzalez Cesar Ivan , Romano Ferdinando , Littera Roberto , Chessa Luchino , Firinu Davide , Del Giacco Stefano , Restivo Angelo , Deidda Simona , Orrù Germano , Scano Alessandra , Onali Simona , Coghe Ferdinando , Kalcev Goce , Cossu Giulia 
Published: March 2022

Background Functioning of Social Behavioral Rhythms (SBRs) may affect resilience toward stressful events across different age groups. However, the impact of SBRs on the coronavirus disease of 2019 (COVID-19) in elder people is yet to ascertain, representing the aim of the present report. Design and methods Follow-up of a peer-reviewed randomized controlled trial on exercise on old adults (365 years), concurrent to the onset of the pandemic-related lockdown. Post-RCT evaluations occurred after further 12 and 36 weeks since the beginning of the lockdown phase. People with Major Depressive Episode (MDE) atweek-48 (follow-up endpoint)were deemed as cases, people without such condition were considered controls. MDE was ascertained using the Patient Health Questionnaire-9 (PHQ-9); SBRs functioning at week 12 onward, through the Brief Symptom Rating Scale (BSRS). Results Seventy-nine individuals (53.2%, females) entered the RCT-follow-up phase. The frequency of MDE did not significantly change before versus during lockdown (OR 2.60, CI95%=0.87-9.13). People with BSRS>1 standard deviation of the whole sample score atweek-12 had an inflated risk of DE during lockdown (OR=5.6, 95%CI:1.5-21.4) compared to those with lower BSRS scores. Such odd hold after excluding individuals with MDD at week-12. The post-hoc analysis could be potentially affected by selection bias. Conclusions Overall, older adults were resilient during the first phase of the pandemic when functioning of pre-lockdown was still preserved, in contrast to the subsequent evaluations when the impairment of daily rhythms was associated with impaired reliance.
Clinical Education Coordinators' Selection and Deselection Criteria of Clinical Education Experiences
Authors: Benedict Jennifer E. , Neil Elizabeth R. , Dougal Zachary J. , Walker Stacy E. , Eberman Lindsey E. 
Published: March 2022

Context
Athletic training students have identified clinical education as the most important aspect of their education when transitioning to practice. However, athletic training students have been frustrated with a lack of engagement, mentorship, and diversity within their clinical education experiences. As such, the selection and deselection of clinical sites is critical to creating effective learning experiences.

Objective
To explore how clinical education coordinators (CECs) select and deselect clinical education experiences (sites and preceptors) for clinical integration and immersion.

Design
Consensual qualitative research.

Setting
Individual teleconference interviews.

Patients or Other Participants
Thirteen CECs (age = 42 ± 8 years, experience in current role = 8 ± 8 years) from accredited professional master's programs who were in their position for at least 1 year and had at least 1 immersive rotation.

Data Collection and Analysis
All interviews were audio recorded and transcribed. A 3-person data analysis team used a multiphase process to identify the emerging domains and categories. Trustworthiness was established through member checking, multiple researcher triangulation, and auditing.

Results
Two themes emerged from the participant responses: accreditation compliance and strategic choices. We found participants expressed the theme of accreditation compliance as a major facilitator when selecting or deselecting clinical education placements. Strategic choices, such as student aspirations and focus on the quantity over the quality, were used by CECs to select clinical education placements which develop student autonomy and provide diverse experiences. However, the CECs engaged in convenient preceptor selection based on geographical location and previous relationships.

Conclusion(s)
Our findings suggest CECs leverage convenient clinical education opportunities that comply with accreditation expectations. CECs should be strategically selecting clinical education opportunities that move beyond accreditation minimum standards and focus on high-quality experiential learning, which leads to autonomous practice and embraces the diversity of the profession.
Time to antibiotic administration in children with febrile neutropenia: Report from a low middle-income country
Authors: Todurkar Namrata , Trehan Amita , Bansal Deepak 
Published: March 2022

Background & objectives:
Antibiotic administration within one hour of presentation is a standard of care goal in the treatment of febrile neutropenia (FN). The objective of this study was to find the proportion of children with FN who had a time to antibiotic administration (TTA) of ≤60 min and evaluate causes for delay.

Methods:
A prospective analysis of children presenting with FN was carried out. The primary outcome was the proportion of patients who received antibiotics within one hour of triage. Predictor variables included the place of presentation, time and day of the week. A root cause analysis was done for delayed TTA.

Results:
A total of 211 children (mean age: 6 yr) with FN were evaluated for TTA. The primary outcome of TTA, (≤60 min) was achieved in 66 per cent children. The odds of delayed TTA were lower when patients were evaluated in the night. Odds of delayed TTA were higher in patients who had no focus of infection, when assessed in the oncology daycare and when assessed over the weekend, but none were statistically significant. Waiting for blood results (30%), delay in preparing antibiotics (21%) and delay in allotting bed (30%) were significant causes for delay.

Interpretation & conclusions:
Two-thirds of the patients achieved the target TTA of ≤60 min. Patients seen during the daytime and on weekends had a delay in TTA compared to those presenting at the evening or night or weekdays. Children with a focus for fever received antibiotics earlier. Logistics for admission and awaiting blood counts were chief causes for delay.
The media and neo-colonisation: examining the relevance of African thought and philosophy in the discourse of decolonisation
Authors: Aketema Joseph , Ladzekpo Joseph Yao Edem Homadji 
Published: March 2022

The media and all that it represents have often had insidious content. People have often used the media to promote their own agenda be it in the area of marketing, finance, governance, entertainment and sports. In Africa, foreign media outlets have dwelled so much on Africa. On most occasions, the media content is fraught with damaging content, which only reinforces earlier existing imagery of Africa as backward continent needing forms of confrontation and actions. This is actually a form of neo-colonisation. In this discussion, we look at the media, an agent of neo- colonisation and how an appreciation of African thought or philosophy can enable a better understanding of the media. The discussion is grounded on cultural norm theory, personal observations of the media landscape in Africa and a brief content analysis of Kwaw Ansah’s Heritage Africa (1989). The discussions conclude that serious regulation of the media is one of the surest ways of reducing the ills in its content and recommends that avenues to promote indigenous knowledge forms through the media be strongly supported to boost African centered media content.
Media strategy and the impact of COVID-19 public awareness in Ekiti State: A cross-sectional study
Authors: Bakare Rasaki Ojo , Isijola Tayo , Bakare Lilian Eguriase 
Published: March 2022

The prevalence of the Covid-19 pandemic, which allegedly stemmed from Wuhan, China, had imposed far-reaching consequences on human existence across the globe. After Nigeria recorded its first case in February 2020, the death toll rose with increased number of confirmed cases. Notably, as experts strove to understand, track, and contain the pandemic, the media kept pushing the frontiers of public awareness faster than the spread. However, the proliferation of disinformation had continued to contend with global responses to the pandemic. It stimulated undesired public behaviours, such as non adherence and public protest, as witnessed in most parts of Nigeria. This research is an empirical study that examines the media strategy responsible for the different behaviours observed in Ekiti state, where the public acceptance of Covid-19 guidelines seemed to have resulted in the considerable containment of the sickness’ spread in the state. The study employs both the qualitative and quantitative research methods, and hinged on Elizabeth Noelle-Neumann’s model (1973) of Powerful effect theory and the “Source credibility theory” of Carl Hovland and Walter Weiss (1951). The researchers observed that in spite of the independent mindedness that characterizes Ekiti people, which challenges most public mobilization endeavours, the populace demonstrated high degree of adherence and compliance to Covid-19 awareness mobilization. In the interest of communal well-being, they volunteered information on violator to the authorities. We discovered that individuals with reckonable public credibility were used as sources of information for the awareness message of Covid-19. Apart from source credibility strategy, geo-coding, which exploited the ethical cultural tenets of the Ekiti world-view was another effective media strategy employed. The researchers hereby recommend the findings of this study as viable and effective media strategies for public enlightenment in the event of future public health crisis in Nigeria.
Forced migration and women as dispossessed gender: An appraisal of Soji Cole’s Embers
Authors: Epochi-Olise Ruth Etuwe 
Published: March 2022

Forced migration is generally inimical to mankind but particularly hazardous to women. However, these hazardous acts which make women vulnerable are hardly considered as substantial enough to warrant an outcry against the migration phenomenon. Women face major challenges resulting from forced migrations, which expose them to violence, rape and other anti-social behaviours imposed on them by the circumstances. All these tend to have significant impacts on their social, economic, cultural and environmental development. This paper, therefore, uses Cole’s Embers to critically interrogate the issues of forced migration as a gendered problem. This work shall expose the claims that the problem of forced migration is an offshoot of the opportunistic post-colonial Nigerian rulers who have assisted to change the narratives of the family structure and peaceful order of society to a chaotic world. The paper focuses on the IDP Camps that are highly fuelled by corruption and the challenges for womanhood.
Provenance and tectonic setting of Leuma Field sediments, Coastal Swamp Depobelt, Niger Delta Basin, Nigeria
Authors: Igbinigie N.S. , Ogbamikhumi A. 
Published: March 2022

Geochemical analysis of sediments recovered from NS-1 well and NS-2 well, Leuma Field, Coastal Swamp Depobelt, Niger Delta Basin was done to establish tectonic setting and provenance. Data for ten major elements and forty-three trace elements were obtained from two boreholes. The geochemical signals display systematic stratigraphic trends in the two wells that depict one source terrain. To determine the provenance of NS-1 well and NS-2 well sediments, Th/Co vs La/Sc plot was utilized which inferred that the sediments from NS-1 and NS-2 wells were derived from felsic source rocks. TiO2 versus Ni bivariate plot was also used to establish the provenance and it revealed that the source of the sediments penetrated by NS-1 and NS-2 wells is predominantly acidic in nature. The provenance of NS-1 and NS-2 wells sediments was further confirmed by considering the ratios of Thorium/Scandium (Th/Sc), Thorium/Cobalt (Th/Co), Chromium/Thorium (Cr/Th) and Lanthanum/Scandium (La/Sc). For NS-1 well, Thorium/Scandium (Th/Sc) range from 1.12-2.01, Thorium/Cobalt (Th/Co) range from 0.91-1.66, Chromium/Thorium (Cr/Th) range from 4.21-16.04 and Lanthanum/Scandium (La/Sc) range from 3.69-8.78. For NS-2 well, Thorium/Scandium (Th/Sc) range from 0.95-2.05, Thorium/Cobalt (Thko/Co) range from 0.94-1.91, Chromium/Thorium (Th/Cr) range from 4.32-15.43 and Lanthanum/Scandium (La/Sc) range from 2.58-6.66. These values inferred that the sediments recovered from NS-1 and NS-2 wells were transported from felsic source rocks.Inorganic geochemical results infer that the tectonic setting for NS-1 and NS-2 wells facies is passive continental margin.
Women’s perception of quality and utilization of antenatal care and delivery services in Oshimili South Local Government Area of Delta State, Nigeria
Authors: Owigho O , Isara AR 
Published: March 2022

Background: The perception of quality of antenatal care and delivery services is one of the several factors that influence utilization of these services. This study assessed the perception of quality and utilization of antenatal care (ANC) and delivery services among women of childbearing age in Oshimili South Local Government Area (LGA) of Delta State, Nigeria.Methods: A cross-sectional study among 301 women aged 15-49 years selected by multistage random sampling technique using mixed methods of data collection. Quantitative data were analyzed using SPSS version 21 while thematic analysis was done for the qualitative data.Results: The mean age of the women was 32.0 ± 2.5 years. Most were married 287 (95.3%), had secondary education 211 (70.1%)) and self-employed 227 (75.4%). One hundred and forty-eight (49.2%) had good perception of technical competence of staff, 132 (43.9%) their safety consciousness and 134 (44.5%) effectiveness/efficiency of drugs. However, 136 (43.5%) had poor perception of waiting time, 118 (39.2%) health workers respectfulness and 116 (38.5%) compassion for patients. Two hundred and seventy-three (90.7%) and 251(83.4%) utilized ANC and delivery services, respectively, while 22 (7.3%) delivered at home.Conclusion: The women’s perception of quality of ANC and delivery services varied across domains. There was a high level of utilization of antenatal care and delivery services. However, there were few traditional birth attendant (TBA) and home deliveries. Addressing the issues of long waiting time and attitude of health workers will encourage full scale utilization of health facilities and discourage TBA and home deliveries
Keywords: Antenatal care; Delivery services; Perception; Quality of care; Utilization; Nigeria
One-year prevalence of domestic violence against women during the COVID-19 pandemic in an urban community in Southern Nigeria
Authors: Adam VY , Erhus E 
Published: March 2022

Background:Violence against women is a major public health challenge particularly in the developing countries. During the COVID-19 pandemic, varied rising incidence of domestic violence against women were reported. This study determined the one-year prevalence of domestic violence against women during the COVID-19 pandemic in an urban community in Southern Nigeria.Methods: This descriptive cross-sectional study was conducted during the COVID-19 pandemic. Multistage sampling technique was utilized in recruiting 616 female respondents from an urban community in Benin City, Nigeria. Structured intervieweradministered questionnaire was the tool for data collection. The questionnaire was adapted from the 2018 Nigeria Demographic Health Survey and the 2006 World Health Organization multi-country survey tool. Data analysis was done using IBM-SPSS version 25.Results: More than a third of the women 221 (35.9%) had been victims of domestic violence in the last one year of the COVID-19 pandemic. The types of domestic violence experienced by the women included: psychological 120 (54.3%), physical 68 (30.8%), sexual 38 (17.2%) and economic 36 (16.3%). Husbands 52 (76.5%) and boyfriends 39 (57.4%) of the victims were the most frequent perpetrators of physical violence.Conclusion: The study revealed a high one-year prevalence of violence against women in the community during the COVID-19 pandemic. Psychological and physical violence were most prevalent and were perpetrated mainly by intimate partners of the women. The social media can be utilized routinely to educate the masses about violence against women. Also, men should be engaged in the prevention of domestic violence programmes through education workshops.
Keywords: Prevalence; Perpetrators; Violence against women; Domestic violence; COVID-19 pandemic; Southern Nigeria
Hypolimnas aubergeri Hecq, 1987 (Nymphalidae: Nymphalinae) a little-known West African butterfly
Authors: Sáfián Sz. , Takano H. 
Published: March 2022

New distribution records of the Guinea Highlands endemic Nymphalid Hypolimnas aubergeri are presented, supplemented by behavioural observations of adults and information on its habitats and potential conservation issues.
A new species of Leptomyrina Butler, 1898 (Lepidoptera: Lycaenidae) from Mts Mecula, Namuli, Inago, Nallume and Mabu in Northern Mozambique
Authors: Bayliss Julian , Brattström Oskar , Bampton Ivan , Collins Steve 
Published: March 2022

This paper describes a new species of Leptomyrina from five mountains in northern Mozambique – Mts Mecula, Namuli, Inago, Nallume and Mabu. Specimens were collected over the course of several years between 2007 and 2019 through a series of biodiversity surveys of the mountains of northern Mozambique. This species differs from others in the group based on the rounded and tail-less shape of the hindwing, and the dusting of powder blue scales on the upper side of the males. The genitalia also show significant differences to others in the group. It is found towards the summits of these mountains at elevations generally over 1000m and feeds on Crassulaceae.
Note : Specialized wing scales in the male of the South African moth Leto venus (Cramer, 1780) (Lepidoptera: Hepialidae)
Authors: Grehan John R. , Ralston Colin D. , Van Noort Simon 
Published: March 2022

The presence of erects rows of elongate rod-like scales on the ventral wing surface and hindwing dorsal surface of Leto venus is illustrated and described. The scales lack basal swellings that are indicative of pheromone secretion. The scales may be involved with pheromone dissemination, function in some other manner, or have no discernible function at all in the sense of an environmental interaction that directly affects survival. The form and arrangement of these scales in L. venus is compared with the specialized elongate wing scales of Puermytrans chiliensis (Chile) and Phassodes vitiensis (Fiji).
Licoflavanone exerts anticancer effects on human nasopharyngeal cancer cells via caspase activation, suppression of cell migration and invasion, and inhibition of m-TOR/PI3K/AKT pathway
Authors: Liu Jun , Song Chengyi , Liang Zhuoping , Long Xiang , Guo Min , Xu Jianle 
Published: March 2022

Purpose: To study the anticancer effect of licoflavanone against human nasopharyngeal HKI carcinoma, and the mechanism involved.
Methods: The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was used to determine the effect of licoflavanone on cell viability, while DAPI staining and western blotting were used to study its proapoptotic effect. Morphological examination was performed under phase contrast microscopy. Transwell chamber assays were used to study cell migration and invasion. The expression levels of mTOR/PI3K/AKT signal pathway-related proteins were assayed by Western blotting.
Results: Licoflavanone markedly suppressed the proliferation of nasopharyngeal HK1 cancer cells in a concentration-reliant pattern (p < 0.01). The anticancer effects of licoflavanone were mediated via induction of pro-apoptotic effects and blocking of mTOR/PI3K/AKT signal pathway. Licoflavanone enhanced the activities of caspase-3, caspase-8, caspase-9 and cleaved caspase-3, as well as Bax and Bad. Moreover, licoflavanone blocked the migration and invasion of HK1 nasopharyngeal cancer cells.
Conclusion: Licoflavanone exerts potent anticancer effects on human nasopharyngeal cancer cells via caspase activation, inhibition of cell migration and cell invasion, and down-regulation of m-TOR/PI3K/AKT signal pathway. Therefore, licoflavanone may be a useful lead drug for the development of a treatment strategy for nasopharyngeal cancer.
Effect of WWOX on epithelial-mesenchymal transition in ovarian cancer cells in vivo, and its association with Elf5/Snail-1 signal pathway
Authors: Song Chunhuan , Yan Yuchen , Liu Yongli , Fang Lisha , Li Qiang , Xu Yang , Yan Hongchao 
Published: March 2022

Purpose: To investigate how WW domain-containing oxidoreductase (WWOX) gene affects epithelial-mesenchymal transition (EMT) of ovarian cancer (OC) cells, and the implication of Elf5/Snail-1 pathway in the process.
Methods: This study employed female BALB/c nude mice aged 6 weeks. The expression levels of E-cadherin, β-Catenin, N-cadherin, Vimentin, Snail1 and Elf5 were assayed using qRT-PCR. The protein levels of WW1, WW2, E-cad, β-Cat, N-cad, vimentin, Snail-1 and Elf5 were determined using western blotting (WB). Invasion changes in cells in each group were analyzed by Transwell invasion test while WWOX and Elf5 were evaluated by GST pull-down test; furthermore, WWOX and ELF5 were evaluated by co-immunoprecipitation (COIP).
Results: Relative to control group, tumor volume and weight of WWOX high-expression mice were significantly decreased, while those of WWOX low-expression group were increased (p < 0.05). The levels of E-cad, Elf5 and β-catenin increased, but those of N-cad, Snail-1 and vimentin decreased in WWOX high expression group. In the WWOX low-expression group, the levels of E-cad, Elf5 and β-cat were down-regulated, while those of N-cad, Snail-1 and vimentin were up-regulated (p < 0.05). The expression of E-cad, Elf5 and β-cat declined; on the other hand, those of N-Cad, Snail-1 and vimentin were elevated after mutation of WW1 domain in WWOX gene (p < 0.05).
Conclusion: Based on the in vivo results, the role of WWOX/Elf5/Snail1 signal route in the epithelial-mesenchymal transition of ovarian cancer, and its related mechanisms have been clarified. This provides a new target for gene therapy of ovarian cancer.
Novel effects of piperlogumine on uterine fibroid tumor: An in vitro mouse model study
Authors: Zhang Mei , Ye Mei , Hou Qingxiang , Yan Bin , Yang Chao , Yang Yi , Ma Li 
Published: March 2022

Purpose: To investigate the in vivo anti-tumor effect of piperlongumine (PL) in a mouse model of leiomyoma xenograft and in leiomyoma cell lines.
Methods: The anti-proliferative effect of PL on ELT-3 cells was determined using MTT assay. Human and rat leiomyoma cells were used for the in vitro investigations. Rat leiomyoma cell lines were treated with various PL concentrations (50 - 100 μM)) for 48 h. Immunodeficient mice were subcutaneously injected with varying doses of estrogen or progesterone, and xenografted with explanting human leiomyoma cells in in vivo experiments. Proliferation assessment, caspase-3 expression, analysis of tumour samples, insertion of pellets of oestrogen-progesterone, tissue treatment and implantation, and immuno-histochemical analyses were carried out using appropriate procedures.
Results: Piperlongumine (PL) produced significant and dose-dependent increase in caspase-3 activity, apoptosis and suppression of cellular proliferation (p < 0.01). Moreover, Western blot data demonstrated that PL decreased phosphorylation of Akt signaling pathway. The results showed significant (p < 0.01) inhibition of tumor growth, including in ultra-sound in vivo studies, when compared with 30-day control and animals treated with PL (100 μg/g). Immuno-histochemical studies showed that PL decreased the expression of proliferation marker in xenografted tumor tissues (p < 0.02).
Conclusion: These results suggest that piperlongumine has potentials as a therapeutic agent for the management of uterine leiomyoma. However, additional studies using human cell lines are required to understand its genetic and molecular mechanisms.