bluuebunny/crossref_metadata_2025_split huggingface dataset:
Central autonomic network alterations in male endurance athletes
Authors: de la Cruz Feliberto , Geisler Maria , Schumann Andy , Herbsleb Marco , Kikinis Zora , Weiss Thomas , Bär Karl-Jürgen 
Published: October 2022

AbstractPhysical exercise causes marked adjustments in brain function and the cardiovascular system. Brain regions of the so-called central autonomic network (CAN) are likely to show exercise-related alterations due to their involvement in cardiac control, yet exercise-induced CAN changes remain unclear. Here we investigate the effects of intensive exercise on brain regions involved in cardiac autonomic regulation using resting-state functional connectivity (rsFC). We explored rsFC of six core regions within CAN, namely ventromedial prefrontal cortex, dorsolateral anterior cingulate cortex, left/right amygdala, and left/right anterior insula, in 20 endurance athletes and 21 non-athletes. We showed that athletes had enhanced rsFC within CAN and sensorimotor areas compared to non-athletes. Likewise, we identified two networks with increased rsFC encompassing autonomic and motor-related areas using network-based statistics analysis. In addition, rsFC displayed an inverse relationship with heart rate, where the stronger rsFC in athletes correlates with their slower heart rate. Despite this significant relationship, mediation analysis revealed that heart rate is a weak mediator of the effect of intensive physical training on rsFC. Our findings prove that physical exercise enhances brain connectivity in central autonomic and sensorimotor networks and highlight the close link between brain and heart.
The relationship between serum uric acid and colorectal cancer: a prospective cohort study
Authors: Li Wenqiang , Liu Tong , Siyin Sarah Tan , Zhang Qingsong , Wang Yiming , Cao Liying , Qu Jun 
Published: October 2022

AbstractSerum uric acid (SUA) may play an important role in the occurrence of colorectal cancer (CRC). This study aims to explore the association of SUA with the risk of CRC incidence by drawing data from the Kailuan Study. We prospectively examined the association between SUA and risk of CRC incidence among 93,356 Chinese. Eligible participants were divided into three groups based on their tertiles of SUA. Cox proportional hazards regression was used to calculate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of CRC. During a median follow-up of 13.02 years, 583 new-onset CRC cases were identified. After adjustments were made for confounders, participants in the highest tertiles of SUA exhibited a 1.55-fold increased risk of CRC compared with patients with the lowest SUA levels (HRT3 vs. T1 = 1.55, 95% CI: 1.09–2.30). The associations of SUA with the risk of CRC were slightly reduced but remained substantial in the competing risk analyses when treating CRC unrelated death as the competing risk event. This study found a positive association of SUA with CRC incidence. Specific prevention efforts could be focused on the population with higher levels of SUA.
Prevalence of intestinal parasites and associated risk factors in HIV positive and negative patients in Northwest Region, Cameroon
Authors: Ntonifor Ngum Helen , Tamufor Abongwe Sidney Warra , Abongwa Lem Edith 
Published: October 2022

AbstractEpidemiological understanding of intestinal parasitic infections is essential for the effective management of HIV infection. Therefore, this study was designed to assess the burden of intestinal parasites and associated risk factors. A cross-sectional study was conducted from May to December 2020 during which 200 HIV positive and 200 HIV negative participants were recruited. A total of 400 stool and venous blood samples were collected and used to identify the different intestinal parasites and for HIV diagnosis and viral load determination respectively. Results obtained revealed that the overall prevalence of intestinal parasites was 11% (44/400). Intestinal parasitosis was significantly (p = 0.025) higher in HIV-positive individuals 14.5% (29/200). Similarly, the prevalence of multiple parasitic infection 4.5% (18/400) and opportunistic helminths 3% (6/400) were insignificantly (p > 0.05) higher among HIV-positive individuals. Furthermore, prevalence of intestinal parasites was significantly (p = 0.004) greater in patients with viral load of > 1000 copies/mL 24.3% (13/46). Age group > 65 years, self-employment, living in Sub-urban areas, being HIV positive, primary level of education, use of potable tap water, and the use of water system toilets for faeces disposal were identified as associated risk factors to intestinal parasites. Intestinal parasites remain public health concern among patients with HIV. Prompt and effective antiretroviral treatment is required to reduce the intensity of the parasite.
The significance of elevated tumor markers among patients with interstitial lung diseases
Authors: Kwon Byoung Soo , Kim Eun Sun , Lim Sung Yoon , Song Myung Jin , Kim Yeon Wook , Kim Hyung-Jun , Lee Yeon Joo , Park Jong Sun , Cho Young-Jae , Yoon Ho Il , Lee Choon-Taek , Lee Jae Ho 
Published: October 2022

AbstractThe clinical implication of using serum tumor markers in patients with interstitial lung disease (ILD) is inconclusive. In this retrospective study, we analyzed the data of 1176 subjects (294 with ILDs and 882 healthy controls). Eligible patients were who had at least one or more available tumor marker results [carbohydrate antigen (CA) 19-9, CA 125, and carcinoembryonic antigen (CEA)] with no evidence of malignancies or other benign diseases that could be related to the increasing concentration of the values. The healthy controls selected from a health screening program were also screened for the presence of active cancer, and matched at a ratio of 1:3 with age and sex. The proportion of patients with abnormal values in the ILD group (121, idiopathic pulmonary fibrosis (IPF); 173, non-IPF-ILDs) was higher than in the matched control group (CEA, 21.5% vs. 5.5%; CA 19-9, 27.9% vs. 4.0%; CA 125, 36.4% vs. 2.0%). In the multivariable analysis, higher CEA levels were associated with shorter survival after adjusting for age, sex, lung function, and ILD subtypes (hazard ratio: 2.323, 95% confidence interval: 1.271–4.248, P = 0.006). In subgroup analysis, CEA remained a prognostic factor in patients with non-IPF-ILDs, but not in those with IPF.
The current status of chronic kidney disease-mineral and bone disorder management in China
Authors: Zhan Ya , He Xin , Hong Daqing , Wang Li , Li Guisen 
Published: October 2022

AbstractChronic kidney disease-mineral and bone disorder (CKD-MBD) is one of the most common complications of patients with chronic kidney disease (CKD). After considering updated international and domestic CKD-MBD management guidelines, the current management status of CKD-MBD in China remains unclear. We aimed to investigate the management status of CKD-MBD in China. A nationwide survey was combined with a real-world study from Sichuan. Targets recommended in KDIGO 2017 and Chinese 2019 guidelines were used as targets. We compared the data between Sichuan from western China and the eastern developed areas of China, and also compared the results of the real-world data from Sichuan with those of DOPPS5. In the questionnaire, a total of 51,039 maintenance hemodialysis (MHD) patients from 272 centers were involved. Estimated achievement rates for Ca (2.1–2.5 mmol/L), P (1.13–1.78 mmol/L), and iPTH (150–600 pg/mL) levels were 57.1%, 41.1% and 52.0%, respectively. Differences in MBD management between Sichuan from questionnaire and central region. In the real-world survey, a total of 7,053 patients were enrolled. Among them, 57.6%, 24.3%, and 55.0% of patients met corrected Ca, serum P, and iPTH targets specified in Chinese 2019 guidelines, respectively. The comprehensive achievement rate was 7.5%. There are differences in MBD management between Sichuan and DOPPS5 regions, with Sichuan being relatively poorer. The level of the above parameters varies among different genders, age groups, and hospital grades. The achievement rate of serum P was higher in tertiary hospitals and elderly patients (P < 0.05). Current MBD management is poor. Phosphate levels in patients treated in secondary and lower hospitals and young dialysis patients should be strengthened.
Behavioral correlates of temporal attention biases during emotional prosody perception
Authors: Guex Raphaël , Grandjean Didier , Frühholz Sascha 
Published: October 2022

AbstractEmotional prosody perception (EPP) unfolds in time given the intrinsic temporal nature of auditory stimuli, and has been shown to be modulated by spatial attention. Yet, the influence of temporal attention (TA) on EPP remains largely unexplored. TA studies manipulate subject’s motor preparedness according to an upcoming event, with targets to discriminate during short attended trials arriving quickly, and, targets to discriminate during long unattended trials arriving at a later time point. We used here a classic paradigm manipulating TA to investigate its influence on behavioral responses to EPP (n = 100) and we found that TA bias was associated with slower reaction times (RT) for angry but not neutral prosodies and only during short trials. Importantly, TA biases were observed for accuracy measures only for angry voices and especially during short trials, suggesting that neutral stimuli are less subject to TA biases. Importantly, emotional facilitation, with faster RTs for angry voices in comparison to neutral voices, was observed when the stimuli were temporally attended and during short trials, suggesting an influential role of TA during EPP. Together, these results demonstrate for the first time the major influence of TA in RTs and behavioral performance while discriminating emotional prosody.
Statistical modeling approach for PM10 prediction before and during confinement by COVID-19 in South Lima, Perú
Authors: Cabello-Torres Rita Jaqueline , Estela Manuel Angel Ponce , Sánchez-Ccoyllo Odón , Romero-Cabello Edison Alessandro , Ávila Fausto Fernando García , Castañeda-Olivera Carlos Alberto , Valdiviezo-Gonzales Lorgio , Eulogio Carlos Enrique Quispe , De La Cruz Alex Rubén Huamán , López-Gonzales Javier Linkolk 
Published: October 2022

AbstractA total of 188,859 meteorological-PM$$_{10}$$

10

data validated before (2019) and during the COVID-19 pandemic (2020) were used. In order to predict PM$$_{10}$$

10

in two districts of South Lima in Peru, hourly, daily, monthly and seasonal variations of the data were analyzed. Principal Component Analysis (PCA) and linear/nonlinear modeling were applied. The results showed the highest annual average PM$$_{10}$$

10

for San Juan de Miraflores (SJM) (PM$$_{10}$$

10

-SJM: 78.7 $$\upmu$$
μ
g/m$$^{3}$$

3

) and the lowest in Santiago de Surco (SS) (PM$$_{10}$$

10

-SS: 40.2 $$\upmu$$
μ
g/m$$^{3}$$

3

). The PCA showed the influence of relative humidity (RH)-atmospheric pressure (AP)-temperature (T)/dew point (DP)-wind speed (WS)-wind direction (WD) combinations. Cool months with higher humidity and atmospheric instability decreased PM$$_{10}$$

10

values in SJM and warm months increased it, favored by thermal inversion (TI). Dust resuspension, vehicular transport and stationary sources contributed more PM$$_{10}$$

10

at peak times in the morning and evening. The Multiple linear regression (MLR) showed the best correlation (r = 0.6166), followed by the three-dimensional model LogAP-LogWD-LogPM$$_{10}$$

10

(r = 0.5753); the RMSE-MLR (12.92) exceeded that found in the 3D models (RMSE $$<0.3$$

<
0.3

) and the NSE-MLR criterion (0.3804) was acceptable. PM$$_{10}$$

10

prediction was modeled using the algorithmic approach in any scenario to optimize urban management decisions in times of pandemic.
Toxic effects of detected pyrethroid pesticides on honeybee (Apis mellifera ligustica Spin and Apis cerana cerana Fabricius)
Authors: Liu Qiongqiong , He Qibao , Zhang Shiyu , Chai Yuhao , Gao Quan , Xiao Jinjing , Fang Qingkui , Yu Linsheng , Cao Haiqun 
Published: October 2022

AbstractTo obtain the presence of environmental contaminants in honeybee and compare the toxicity of the detected pesticides to Apis mellifera ligustica Spin and Apis cerana cerana Fabricius. In this work, 214 honeybee samples were collected to simultaneous monitoring 66 pesticides between 2016 and 2017 in China. A modified QuEChERS extraction method coupled with multi-residue analytical methods by Ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and Gas chromatography-mass spectrum (GC–MS). Among, four pyrethroid pesticides were selected to test and compare the acute oral toxicities of two honeybees. And the survival risk of beta-cypermethrin was analyzed to them. Using this method, 21 compounds were detected, including 3 neonicotinoids, 5 pyrethroids, 5 organophosphorus and 8 others. Importantly, detected frequencies of pyrethroid pesticides were accounted for 53.3%. Among, acute toxicity values (LD50) of four pyrethroid pesticides to the A.m. ligustica were higher than of that the A.c. cerana. When they were exposed to the same concentration of beta-cypermethrin (0.2906 mg/L), the survival rate of the A.m. ligustica (40.0%) was higher than the A.c. cerana (18.9%). Our work is valuable to analyze multiple pesticide residues of honeybees and evaluate the survival risk of two honeybee species, which also provides a basis for the risk assessment.
Artificial intelligence in (gastrointestinal) healthcare: patients’ and physicians’ perspectives
Authors: van der Zander Quirine E. W. , van der Ende - van Loon Mirjam C. M. , Janssen Janneke M. M. , Winkens Bjorn , van der Sommen Fons , Masclee Ad. A. M. , Schoon Erik J. 
Published: October 2022

AbstractArtificial intelligence (AI) is entering into daily life and has the potential to play a significant role in healthcare. Aim was to investigate the perspectives (knowledge, experience, and opinion) on AI in healthcare among patients with gastrointestinal (GI) disorders, gastroenterologists, and GI-fellows. In this prospective questionnaire study 377 GI-patients, 35 gastroenterologists, and 45 GI-fellows participated. Of GI-patients, 62.5% reported to be familiar with AI and 25.0% of GI-physicians had work-related experience with AI. GI-patients preferred their physicians to use AI (mean 3.9) and GI-physicians were willing to use AI (mean 4.4, on 5-point Likert-scale). More GI-physicians believed in an increase in quality of care (81.3%) than GI-patients (64.9%, χ2(2) = 8.2, p = 0.017). GI-fellows expected AI implementation within 6.0 years, gastroenterologists within 4.2 years (t(76) =  − 2.6, p = 0.011), and GI-patients within 6.1 years (t(193) =  − 2.0, p = 0.047). GI-patients and GI-physicians agreed on the most important advantages of AI in healthcare: improving quality of care, time saving, and faster diagnostics and shorter waiting times. The most important disadvantage for GI-patients was the potential loss of personal contact, for GI-physicians this was insufficiently developed IT infrastructures. GI-patients and GI-physicians hold positive perspectives towards AI in healthcare. Patients were significantly more reserved compared to GI-fellows and GI-fellows were more reserved compared to gastroenterologists.
A solution for the rational dispatching of concrete transport vehicles
Authors: Guo Zhi-guang , Liu Yong-fu , Ao Chang-jiang 
Published: October 2022

AbstractThe amount of concrete needed in the construction of projects is enormous. The concrete dispatching in construction is, however, chaotic and causes grievous waste due to the tight construction schedule, heavy tasks, and improper transport vehicle dispatching by the constructor. This paper proposes a more realistic objective function in the vehicle dispatching algorithm and offers a solution to the rational dispatching of concrete transport vehicles. The analysis of the calculation example validates the feasibility of the built model, which provides more appropriate dispatching and more balanced distribution, meets the needs of the worksite and mixing station to the greatest extent and improves the level of project refinement and process management. Therefore, the model is worth promoting in future practice.
HTLV infection in Brazil’s second-largest indigenous reserve
Authors: Amianti Carolina , Bandeira Larissa Melo , Cesar Gabriela Alves , Weis-Torres Sabrina , Tanaka Tayana Serpa Ortiz , Machado Indianara Ramires , Gonçalves Crhistinne Cavalheiro Maymone , Simionatto Simone , Schnaufer Erica Cristina dos Santos , Freitas Felipe Bonfim , Vallinoto Antonio Carlos Rosário , Croda Julio , Motta-Castro Ana Rita Coimbra 
Published: October 2022

AbstractHuman T-lymphotropic viruses 1 and 2 (HTLV-1/2) have a worldwide distribution. HTLV-1 has been associated with several diseases, including an aggressive malignant disease known as adult T-cell leukemia/lymphoma and a chronic inflammatory neurological disease called HTLV-1-associated myelopathy, while HTLV-2 has not been definitively associated with diseases. HTLV-2 is most prevalent in specific groups such as injecting drug users and the indigenous population. In Brazil, most studies about HTLV in indigenous are carried out in indigenous communities from the north of the country. Mato Grosso do Sul (MS), Central Brazil, has the second-largest indigenous population in Brazil. However, there is no available data about HTLV infection in this group. We conducted the first investigation of HTLV-1/2 infection prevalence in the indigenous population from Jaguapiru and Bororó villages in Dourados City, MS, to provide the prevalence and molecular characterization of HTLV. For that, a total of 1875 indigenous participated in the study. All the serum samples were screened by an enzyme-linked immunosorbent assay commercial kit for the presence of anti-HTLV-1/2 antibodies. Positive samples were confirmed by HTLV-1/2 Western Blot assay. The HTLV-1 5’LTR region was detected by nested PCR amplification and sequenced by Sanger. Most of the study population declared belonging to Guarani-Kaiowá ethnicity (69.18%), 872 (46.51%), and 1003 (53.49%) were from Jaguapiru and Bororó villages, respectively. The median age of participants was 31 years, and 74.24% were females. Two individuals were detected with HTLV-1 (0.1%; CI 95% 0.1–0.2). The phylogenetic analysis revealed that isolates belong to the Cosmopolitan subtype and the Transcontinental subgroup (HTLV-1aA). The low HTLV-1 prevalence found in this study is similar to that observed among blood donors, and pregnant populations from Mato Grosso do Sul. The absence of HTLV-2 infection among these Brazilian indigenous communities would suggest a distinct behavior pattern from other indigenous populations in Brazil.
A post-trial follow-up study of pentosan polysulfate monotherapy on preventing recurrent urinary tract infection in women
Authors: Lee Yuan-Ju , Chang Shang-Jen , Lin Hsiu-Ying , Meng En , Chueh Jeff S. , Tseng Chi-Shin 
Published: October 2022

AbstractFor women with recurrent urinary tract infection (UTI), previous U101 study has shown that pentosan polysulfate sodium (PPS) monotherapy for 16 weeks significantly reduced UTI episodes in the treatment group throughout the trial period. In this follow-up study, we aimed to assess whether the effects of PPS would last after completion of the trial to prevent recurrent UTIs. Conducted from 2018 to 2019, the U101 study was a multicenter, prospective, phase 2a, randomized trial, enrolling women with recurrent UTI to study the effects of a 16-week oral PPS monotherapy. After approximately two years, the follow-up was conducted by phone interview, obtaining data including self-reported UTI events, quality of life questionnaire, and adverse events. The primary endpoint of follow-up study was UTI recurrence-free survival and the secondary endpoints were quality of life and adverse events. Approximately two years after completion of the trial, the rate of recurrent UTI was 25% (3 of the 12 patients) in the PPS group and 85.7% (12 of the 14 patients) in the control group. Over the entire follow-up period, the UTI recurrence-free survival was significantly better in the PPS group than in the control group (log-rank test p < 0.001). The quality of life at two years was significantly improved in the PPS when compared to the control group (91.7 vs. 77.5, p < 0.001). No late adverse event was observed after cessation of the treatment. In this study, sixteen weeks of PPS monotherapy in women with recurrent UTI significantly reduced the numbers of recurrent UTI episodes during the 2-year follow-up.
Time-dependent measurement of plasmon-induced charge separation on a gold nanoparticle/TiO2 interface by electrostatic force microscopy
Authors: Misaka Tomoki , Ohoyama Hiroshi , Matsumoto Takuya 
Published: October 2022

AbstractPlasmon-induced charge separation (PICS) is an efficient way to use the hot carriers generated by localized surface plasmon resonance. Although the ultrafast dynamics of hot carrier generation and annihilation itself are well understood, the slow dynamics of PICS are not, despite their importance for the use of hot carriers in chemical reactions. In this work, we directly observed the slow dynamics of PICS on an Au nanoparticle (NP)/TiO2interface by using electrostatic force microscopy with time-resolved measurements obtained by sideband signal of frequency shift. The change in contact potential difference induced by PICS had a bias voltage dependence, indicating that the number of holes in the Au NPs ($$[{\mathrm{h}}_{\mathrm{AuNP}}^{+}]$$[hAuNP+]) accumulated by laser irradiation depended on bias voltage. The decay constant for the annihilation of the separated charge on the Au NPs at the Au NP/TiO2interface was directly determined to be ca. 150 ms, and the annihilation process was discussed in a simple model based on the transient Schottky barrier.
Fabrication of polyhedral Cu–Zn oxide nanoparticles by dealloying and anodic oxidation of German silver alloy for photoelectrochemical water splitting
Authors: Bahnasawy Nour , Elbanna Abdussalam M. , Ramadan Mohamed , Allam Nageh K. 
Published: October 2022

AbstractA significant effort has been dedicated to the synthesis of Cu–Zn oxide nanoparticles as a robust photocathode material for photoelectrochemical water splitting. Cu–Zn oxide nanoparticles were formed by controlled anodization of German silver (Cu–Zn–Ni) alloy in an aqueous electrolyte. Scanning electron microscopy (SEM) demonstrates the dependence of the obtained nanostructures on the anodization time. The X-ray diffraction (XRD) patterns showed the formation of copper oxide (CuO) and zinc oxide (ZnO) nanoparticles with good stability. This was also confirmed by the compositional X-ray photoelectron spectroscopy (XPS) analysis. The obtained polyhedral nanoparticles showed high optical activity with adequate bandgap energy. These optimized nanoparticles achieved boosted photocurrent of − 0.55 mA/cm2 at − 0.6 V vs. SCE under AM 1.5 illumination, confirming the role of the optimized dealloying and thermal treatment in tuning the photoelectrochemical performance of the material.