bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geographical prevalence of SARS-CoV-2 variants, August 2020 to July 2021
Authors: Chan Wai Sing , Lam Yuk Man , Law Janet Hei Yin , Chan Tsun Leung , Ma Edmond Shiu Kwan , Tang Bone Siu Fai 
Published: March 2022

AbstractWe extracted one-year genomic data (August 2020–July 2021) from GISAID EpiCoV™ database and estimated monthly proportions of 11 SARS-CoV-2 variants in various geographical regions. From continental perspective, Delta VOC predominated in Africa, Asia, Europe, North America and Oceania, with proportions of 67.58–98.31% in July 2021. In South America, proportion of Delta VOC (23.24%) has been approaching the predominant yet diminishing Gamma VOC (56.86%). We further analyzed monthly data on new COVID-19 cases, new deaths, vaccination status and variant proportions of 6 countries. Delta VOC predominated in all countries except Brazil (Gamma VOC) in July 2021. In most occasions, rise and predominance of Alpha, Beta, Gamma, Delta and Zeta variants were accompanied with surges of new cases, especially after the time point of major lineage interchange. The ascending phases of new cases lasted for 1–5 months with 1.69- to 40.63-fold peak growth, whereas new death tolls varied with regional vaccination status. Our data suggested surges of COVID-19 cases might be predicted from variant surveillance data. Despite vaccine breakthroughs by Delta VOC, death tolls were more stable in countries with better immunization coverage. Another takeaway is the urgent need to improve vaccine efficacy against Delta and emerging variants.
Characterization and reduction of non-endocrine cells accompanying islet-like endocrine cells differentiated from human iPSC
Authors: Hiyoshi Hideyuki , Sakuma Kensuke , Tsubooka-Yamazoe Noriko , Asano Shinya , Mochida Taisuke , Yamaura Junji , Konagaya Shuhei , Fujii Ryo , Matsumoto Hirokazu , Ito Ryo , Toyoda Taro 
Published: March 2022

AbstractThe differentiation of pancreatic endocrine cells from human pluripotent stem cells has been thoroughly investigated for their application in cell therapy against diabetes. Although non-endocrine cells are inevitable contaminating by-products of the differentiation process, a comprehensive profile of such cells is lacking. Therefore, we characterized non-endocrine cells in iPSC-derived pancreatic islet cells (iPIC) using single-cell transcriptomic analysis. We found that non-endocrine cells consist of (1) heterogeneous proliferating cells, and (2) cells with not only pancreatic traits but also liver or intestinal traits marked by FGB or AGR2. Non-endocrine cells specifically expressed FGFR2, PLK1, and LDHB. We demonstrated that inhibition of pathways involving these genes selectively reduced the number of non-endocrine cells in the differentiation process. These findings provide useful insights into cell purification approaches and contribute to the improvement of the mass production of endocrine cells for stem cell-derived cell therapy for diabetes.
Organelle specific fluorescent phenomics and transcriptomic profiling to evaluate cellular response to tris(1,3 dichloro 2 propyl)phosphate
Authors: Haque Md Mamunul , Voitsitskyi Taras , Lee Jun-Seok 
Published: March 2022

AbstractTris(1,3-dichloro-2-propyl)phosphate (TDCPP) has been suspected to cause toxicity invertebrates, but its phenotypic effects and the underlying regulatory mechanism have not been fully revealed. Generally, cellular responses tightly control and affect various phenotypes. The scope of the whole organism or cellular toxicological phenotyping, however, has been limited, and quantitative analysis methods using phenotype data have not been fully established. Here, we demonstrated that fluorescence imaging of sub-organelle-based phenomic analysis together with transcriptomic profiling can enable a comprehensive understanding of correlations between molecular and phenomic events. To reveal the cellular response to TDCPP exposure, we obtained three sub-organelle images as fluorescent phenotypes. Transcriptomic perturbation data were measured from the RNA-seq experiment, and both profiling results were analyzed together. Interestingly, organelle phenomic data showed a unique fluorescent intensity increase in the endoplasmic reticulum (ER), and pathway analysis using transcriptomic data also revealed that ER was significantly enriched in gene ontology terms. Following the series of analyses, RNA-seq data also revealed potential carcinogenic effects of TDCPP. Our multi-dimensional profiling approach for organophosphate chemicals can uniquely correlate phenotypic changes with transcriptomic perturbations.
The clinical application of a scoring protocol to select endarterectomy or stenting for carotid artery stenosis
Authors: Chung Joonho , Kim Jung-Jae , Kim Yong Bae , Suh Sang Hyun , Lee Kyung-Yul 
Published: March 2022

AbstractPreviously we described the protocol-based decision for choosing the proper surgical treatment option for carotid stenosis. The objective of this study is to describe our experiences of using this scoring protocol in the selection of endarterectomy or stenting for carotid stenosis. Between October 2014 and March 2018, the scoring protocol was applied to a total of 105 consecutive patients. Eighty (76.2%) patients had symptomatic stenosis ≥ 50%, and 25 (23.8%) patients had asymptomatic stenosis ≥ 80%. We also speculated about how effectively the protocol worked in the real clinical setting. Stenting was performed in 73 patients and endarterectomy in 32 patients. Overall, 98 (93.3%) patients were treated according to the protocol, while the protocol was violated in seven (6.7%) patients. Sixty-one (58.1%) patients received treatments that were decided by the protocol. There were 37 (35.2%) patients who had the same score for both treatment options. Among these patients, 28 patients underwent stenting and nine patients underwent endarterectomy. In the stenting cases, 90.4% of the patients followed the protocol and violations occurred in 9.6%. In the endarterectomy cases, all of the patients followed the protocol. Overall, one patient had a procedure-related complication without morbidity. During the 12-month follow-ups, there were no restenoses or major strokes. Minor strokes were diagnosed in three (2.8%) patients. In patients with carotid artery stenosis, stenting and endarterectomy should be considered simultaneously together, not against each other. Our scoring protocol can be used to weigh these options and applied in clinical practice.
Application of fingernail samples as a biomarker for human exposure to arsenic-contaminated drinking waters
Authors: Shokoohi Reza , Khazaei Mohammad , Karami Manoochehr , Seid-mohammadi Abdolmotaleb , Khazaei Salman , Torkshavand Zahra 
Published: March 2022

AbstractThis study evaluated the relationship between arsenic uptake via drinking water ingestion and arsenic concentration in fingernails as a biomarker for human exposure. For this purpose, we collected fingernail samples from 40 healthy participants of arsenic-affected rural regions of Kaboudrahang County, the west of Iran. A total of 49 fingernail samples were also collected from individuals who lived in areas where contamination of drinking water sources with arsenic had not been reported. It was found that the fingernails arsenic contents in 50 and 4.08% of the samples collected from arsenic-contaminated and reference villages were higher than the normal arsenic values of nails (0.43–1.08 µg/g), respectively. Based on the results of adjusted multiple linear regression, a significant association was found between groundwater and fingernails arsenic concentration (p < 0.001). Moreover, a statistically significant association was shown between arsenic in the fingernail samples and gender (p = 0.037). Fingernails arsenic contents were not significantly affected by other variables including age, smoking habits, and BMI (p > 0.05). In light of the results of this study, the use of biological indicators such as fingernail tissues due to easier sampling and less risk of external contamination is suitable for assessing exposure to heavy metals in contaminated areas.
Synthesis of spiropyrans via the Rh(iii)-catalyzed annulation of 3-aryl-2H-benzo[b][1,4]oxazines with diazo ketoesters
Authors: Zhang Jing Jing , Zhang Mengying , Lu Mingxin , He Yuhao , Li Song , Fan Liangxin , Zhang Xinle , Wu Jia-Kai , Yang Xifa 
Published: March 2022

An efficient Rh(iii)-catalyzed 1 : 2 coupling of 3-aryl-2H-benzo[b][1,4]oxazines with diazo ketoesters has been realized via twofold C–H activation followed by unusual [3+3] and [4+2] annulation, providing a straightforward strategy to access polycyclic spiropyrans.
Drawing Talking: Listening to Children With Speech Sound Disorders
Authors: McCormack Jane , McLeod Sharynne , Harrison Linda J. , Holliday Erin L. 
Published: March 2022

Purpose:
Listening to children using age-appropriate techniques supports evidence-based clinical decision-making. In this article, we test the Sound Effects Study Drawing Protocol, an arts-based technique, to support children with speech sound disorder (SSD) to express their views about talking.

Method:
Participants were 124 Australian children aged 4–5 years in the Sound Effects Study. Their parents and teachers were concerned about their talking, and they were assessed as having SSD on the Diagnostic Evaluation of Articulation and Phonology. Drawings and children's interpretations were elicited then analyzed using the (a) Who Am I? Draw-a-Person Scale and (b) Sound Effects Study Focal Points.

Results:
Drawings were developmentally typical for 4- to 5-year-olds. The six Sound Effects Study Focal Points were identified across the 124 drawings: body parts and facial expressions, talking and listening, relationships and connection, positivity, negativity, and no talking. Participants portrayed talking and listening as an action requiring mouths and ears represented by symbols (letters, speech bubbles) or as an activity with a variety of people. Children typically portrayed themselves as happy when talking; however, some portrayed negativity and some chose not to draw talking.

Conclusions:
In keeping with Articles 12 and 13 of the Convention on the Rights of the Child, this research demonstrated that 4- to 5-year-old children with SSD can express their views about talking via drawing. Professionals may use the Sound Effects Study Drawing Protocol as a child-friendly technique to support children to express views to guide holistic, evidence-based, child-centered speech-language pathology practice.
How to Document Scientific and Clinical Impact of Research: Six Steps to Success
Authors: Nicholson Nannette , Smith Sherri L. 
Published: March 2022

Purpose:
The purpose of this article was to provide a brief tutorial about impact metrics and how to use these metrics to document scientific impact. In addition, examples are provided that describe possible ways to document clinical impact of research.

Method:

We briefly introduce traditional bibliometrics for journals (e.g., impact factor), articles (e.g., citation counts), and authors (e.g.,
h
index). We describe alternative metrics (i.e., altmetrics) that focus on other types of dissemination metrics such as usage (e.g., downloads, reads, and views), engagement (e.g., comments, shares, and replies), and attention (e.g., Altmetric Attention Score). We also discuss how these metrics are used by others to make decisions about employment, tenure and promotion, funding, and the like. We detail six steps to documenting the scientific and clinical impact of your research. Steps include establishing an ORCID (Open Researcher and Contributor ID) account, creating research profiles on academic platforms, engaging in broad dissemination activities, harvesting bibliometric and altmetric data, adding bibliometric and altmetric information to your curriculum vitae (CV), and submitting your promotion and tenure portfolio with confidence. Examples for ways in which scientific impact and clinical impact of research can be documented on your CV are provided.

Results:
Readers will have an introductory understanding of bibliometrics and altmetrics and how these data may be used in the evaluation of their research impact and reach. Some strategies are offered as means to increase scientific and clinical impact of research using research profiles on academic platforms. Others are suggestions for documenting scholarly activity aimed to increase clinical impact of research.

Conclusions:
Creating profiles with organizations that document scientific impact and engaging in the research community using less traditional methods may allow researchers to achieve a broader reach and greater clinical impact for their research. Documenting such research outputs should facilitate a researcher's career advancement.
Correlations ofr-process elements in very metal-poor stars as clues to their nucleosynthesis sites
Authors: Farouqi K. , Thielemann F.-K. , Rosswog S. , Kratz K.-L. 
Published: March 2022

Aims.Various nucleosynthesis studies have pointed out that ther-process elements in very metal-poor (VMP) halo stars might have different origins. By means of familiar concepts from statistics (correlations, cluster analysis, and rank tests of elemental abundances), we look for causally correlated elemental abundance patterns and attempt to link them to astrophysical events. Some of these events produce ther-process elements jointly with iron, while others do not have any significant iron contribution. We try to (a) characterize these different types of events by their abundance patterns and (b) identify them among the existing set of suggestedr-process sites.Methods.The Pearson and Spearman correlation coefficients were used in order to investigate correlations amongr-process elements (X,Y) as well as their relation to iron (Fe) in VMP halo stars. We gradually tracked the evolution of those coefficients in terms of the element enrichments [X/Fe] or [X/Y] and the metallicity [Fe/H]. This approach, aided by cluster analysis to find different structures of abundance patterns and rank tests to identify whether several events contributed to the observed pattern, is new and provides deeper insights into the abundances of VMP stars.Results.In the early stage of our Galaxy, at least threer-process nucleosynthesis sites have been active. The first two produce and eject iron and the majority of the lighterr-process elements. We assign them to two different types of core-collapse events, not identical to regular core-collapse supernovae (CCSNe), which produce only light trans-Fe elements. The third category is characterized by a strongr-process and is responsible for the major fraction of the heavy mainr-process elements without a significant coproduction of Fe. It does not appear to be connected to CCSNe, in fact most of the Fe found in the relatedr-process enriched stars must come from previously occurring CCSNe. The existence of actinide boost stars indicates a further division among strongr-process sites. We assign these two strongr-process sites to neutron star mergers without fast black hole formation and to events where the ejecta are dominated by black hole accretion disk outflows. Indications from the lowest-metallicity stars hint at a connection with massive single stars (collapsars) forming black holes in the early Galaxy.
Spectral softening in core-collapse supernova remnant expanding inside wind-blown bubble
Authors: Das Samata , Brose Robert , Meyer Dominique M.-A. , Pohl Martin , Sushch Iurii , Plotko Pavlo 
Published: March 2022

Context. Galactic cosmic rays (CRs) are widely assumed to arise from diffusive shock acceleration, specifically at shocks in supernova remnants (SNRs). These shocks expand in a complex environment, particularly in the core-collapse scenario as these SNRs evolve inside the wind-blown bubbles created by their progenitor stars. The CRs at core-collapse SNRs may carry spectral signatures of that complexity.
Aims. We study particle acceleration in the core-collapse SNR of a progenitor with an initial mass of 60 M⊙ and realistic stellar evolution. The SNR shock interacts with discontinuities inside the wind-blown bubble and generates several transmitted and reflected shocks. We analyse their impact on particle spectra and the resulting emission from the remnant.
Methods. To model the particle acceleration at the forward shock of a SNR expanding inside a wind bubble, we initially simulated the evolution of the pre-supernova circumstellar medium (CSM) by solving the hydrodynamic equations for the entire lifetime of the progenitor star. As the large-scale magnetic field, we considered parameterised circumstellar magnetic field with passive field transport. We then solved the hydrodynamic equations for the evolution of a SNR inside the pre-supernova CSM simultaneously with the transport equation for CRs in test-particle approximation and with the induction equation for the magnetohydrodynamics in 1D spherical symmetry.
Results. The evolution of a core-collapse SNR inside a complex wind-blown bubble modifies the spectra of both the particles and their emission on account of several factors including density fluctuations, temperature variations, and the magnetic field configuration. We find softer particle spectra with spectral indices close to 2.5 during shock propagation inside the shocked wind, and this softness persists at later evolutionary stages. Further, our calculated total production spectrum released into the interstellar medium demonstrates spectral consistency at high energy (HE) with the injection spectrum of Galactic CRs, which is required in propagation models. The magnetic field structure effectively influences the emission morphology of SNRs as it governs the transportation of particles and the synchrotron emissivity. There is rarely a full correspondence of the intensity morphology in the radio, X-ray, and gamma-ray bands.
The role of customer personality in premium banking services
Authors: Ho Shirie Pui Shan , Wong Amy 
Published: March 2022

AbstractThis paper examines the effects of customer personality, trust, and satisfaction on customer loyalty in premium banking services. Based on a survey of 210 high-net-worth premium banking customers, the study found that the customer personality dimensions of conscientiousness, extroversion, and agreeableness affected trust, while extroversion affected satisfaction. Trust displayed a significant influence on both satisfaction and customer loyalty, while satisfaction partially mediated the effect on customer loyalty via trust. The findings can help managers of affluent banking services understand the important dimensions of customer personality in relational exchanges and develop relevant relationship management strategies to deliver satisfaction and enhance customer loyalty.
Diffusion and distal linkages govern interchromosomal dynamics during meiotic prophase
Authors: Newman Trent A. C. , Beltran Bruno , McGehee James M. , Elnatan Daniel , Cahoon Cori K. , Paddy Michael R. , Chu Daniel B. , Spakowitz Andrew J. , Burgess Sean M. 
Published: March 2022

Significance
Essential for sexual reproduction, meiosis is a specialized cell division required for the production of haploid gametes. Critical to this process are the pairing, recombination, and segregation of homologous chromosomes (homologs). While pairing and recombination are linked, it is not known how many linkages are sufficient to hold homologs in proximity. Here, we reveal that random diffusion and the placement of a small number of linkages are sufficient to establish the apparent “pairing” of homologs. We also show that colocalization between any two loci is more dynamic than anticipated. Our study provides observations of live interchromosomal dynamics during meiosis and illustrates the power of combining single-cell measurements with theoretical polymer modeling.
A continuum of teacher collaboration to enhance the effectiveness of bilingual education programmes
Authors: Lo Yuen Yi , Poon Scarlet , Rui Xiaochen 
Published: March 2022

Abstract
Bilingual education programmes are characterised by the use of students’ second/foreign/additional language (L2)
as the medium of instruction for content subjects. In many educational contexts, such programmes are implemented by content
subject specialists who have not received sufficient training in helping students master content and L2 simultaneously.
Professional development is therefore necessary for this group of teachers. One potential professional development model is
promoting collaboration between content and L2 teachers in the same school. Previous studies have explored different forms of
cross-curricular collaboration, teachers’ attitudes and factors affecting its effectiveness. This paper seeks to extend the
current discussion by investigating different models of teacher collaboration, based on a multi-case study of secondary schools
adopting English (L2) as the medium of instruction for some or all subjects in Hong Kong. With various sources of data and
cross-case comparison, this paper conceptualises a continuum of teacher collaboration in bilingual education programmes.
Gaining and Losing Control: Tattoos and Interpretive Sovereignty
Authors: Tabea Jerrentrup Maja 
Published: March 2022

AbstractThis article explores the ways in which individuals are able to create their own bodies, influence the perception of others, and shape their memories by getting tattooed. Tattoos can be a powerful way of gaining control and experiencing oneself as an active creator of one’s life. However, in the process of getting tattooed, people have to be passive: they are at the mercy of a person whom they usually do not know well and who has specific personal interests in tattooing others—working efficiently and earning money or a good reputation. Further, the tattooees cannot control how other people will interpret their tattoos. Yet, most tattooed individuals seem to regard the active aspects as more important than the passive act of getting tattooed and interpreted by others and qdevelop strategies to reinterpret their loss of control.
Qualia of Proximity and Materiality in Classic Maya Hieroglyphs
Authors: Matsumoto Mallory E. 
Published: March 2022

AbstractDrawing on the Peircean concepts of qualia and qualisign (Munn 1986; Keane 2003; Chumley and Harkness 2013), I propose that Classic Maya hieroglyphs were associated with two fundamental sensorial experiences, materiality and proximity, which were expressed by coordinating lexical, morphological, syntactic, and pragmatic strategies. I argue that Classic Mayan terminology distributed materiality between three basic qualisigns by privileging tactile and technological experiences of scribal production above interaction with the finished text. Qualia of proximity, in turn, implied differential access to hieroglyphic writing and its recorded knowledge with qualisigns that distinguished producers from patrons or owners. A semiotic approach articulates the material, the corporal, and the social in Classic Maya ontologies of writing and reveals the relational nature of hieroglyphic production and access. It also offers a theoretical consideration of the role of morphology, syntax, and pragmatics in culturally conditioned experiences of qualities and their interpretations.