bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of work and social participation in patients with psoriatic arthritis in the Netherlands: an observational study
Authors: van Hal Tamara W. , Mulder Michelle L. M. , Wenink Mark H. , Vriezekolk Johanna E. 
Published: August 2022

Abstract
Background
Psoriatic arthritis can cause pain, disability, and permanent joint damage. This can lead to impairments in work and social participation. Little is known about the extent of these impairments in routine practice. With this study, we aim to examine the extent of work and activity impairment in (subgroups of) Dutch patients with psoriatic arthritis (PsA), and to examine determinants associated with this impairment.

Methods
This is an observational study using data collected from the electronic health records of PsA patients treated at the Sint Maartenskliniek, the Netherlands. Data about work and activity impairment were collected via the Work Productivity and Activity Impairment questionnaire. To compare our PsA-cohort with the Dutch general population, we used age- and sex-matched data derived from the Central Bureau of Statistics. Regression analyses were performed to examine determinants of work and activity impairment.

Results
In total, 246 patients were included, of which 126 (51.2%) were female. Mean age (S.D.) was 55.7 (13.2) years. Compared with the Dutch general population, work for pay (WFP) was significantly lower in PsA (52.9% versus 62.6%, P < 0.001). In PsA, younger age and better physical function were associated with WFP status (P < 0.05). Higher disease activity, worse physical function, and worse mental health-related quality of life were associated with both more work and activity impairment (P < 0.05). Furthermore, reaching low disease activity status (LDA) according to Psoriatic ArthritiS Disease Activity Score (PASDAS; ≤ 3.2) was associated with less work and activity impairment than reaching LDA according to DAS28-CRP (≤ 2.9) (P < 0.05).

Conclusions
In PsA patients, worse physical function was associated with a lower likelihood of having WFP, and higher work and activity impairment. PASDAS LDA as a goal for treat to target, compared to DAS28-CRP, appears to favour the reduction of work and activity impairment.
Hands-on training in structural biology, a tool for sustainable development in Africa series 4
Authors: Ouologuem Dinkorma T. , Maiga Fatoumata O. , Dara Antoine , Djimdé Abdoulaye , Traore Daouda A. K. , Nji Emmanuel 
Published: August 2022

ABSTRACT
Structural biology is an essential tool for understanding the molecular basis of diseases, which can guide the rational design of new drugs, vaccines, and the optimisation of existing medicines. However, most African countries do not conduct structural biology research due to limited resources, lack of trained persons, and an exodus of skilled scientists. The most urgent requirement is to build on the emerging centres in Africa – some well-established, others growing. This can be achieved through workshops that improve networking, grow skills, and develop mechanisms for access to light source beamlines for defining X-ray structures across the continent. These would encourage the growth of structural biology, which is central to understanding biological functions and developing new antimicrobials and other drugs. In this light, a hands-on training workshop in structural biology series 4 was organised by BioStruct-Africa and the Malaria Research and Training Center (MRTC) in Bamako, Mali, to help bridge this gap. The workshop was hosted by MRTC from the 25th to 28th of April 2022. Through a series of lectures and practicals, the workshop enlightened the participants on how structural biology can be utilised to find solutions to the prevalent diseases in Africa. The short training gave them an overview of target selection, protein production and purification, structural determination techniques, and analysis in combination with high-throughput, structure-guided, fragment-based drug design.
A multidimensional metabolomics workflow to image biodistribution and evaluate pharmacodynamics in adult zebrafish
Authors: Jackstadt Madelyn M. , Chamberlain Casey A. , Doonan Steven R. , Shriver Leah P. , Patti Gary J. 
Published: August 2022

ABSTRACT
An integrated evaluation of the tissue distribution and pharmacodynamic properties of a therapeutic is essential for successful translation to the clinic. To date, however, cost-effective methods to measure these parameters at the systems level in model organisms are lacking. Here, we introduce a multidimensional workflow to evaluate drug activity that combines mass spectrometry-based imaging, absolute drug quantitation across different biological matrices, in vivo isotope tracing and global metabolome analysis in the adult zebrafish. As a proof of concept, we quantitatively determined the whole-body distribution of the anti-rheumatic agent hydroxychloroquine sulfate (HCQ) and measured the systemic metabolic impacts of drug treatment. We found that HCQ distributed to most organs in the adult zebrafish 24 h after addition of the drug to water, with the highest accumulation of both the drug and its metabolites being in the liver, intestine and kidney. Interestingly, HCQ treatment induced organ-specific alterations in metabolism. In the brain, for example, HCQ uniquely elevated pyruvate carboxylase activity to support increased synthesis of the neuronal metabolite, N-acetylaspartate. Taken together, this work validates a multidimensional metabolomics platform for evaluating the mode of action of a drug and its potential off-target effects in the adult zebrafish.
This article has an associated First Person interview with the first author of the paper.
Network upgrade exploiting multi band: S- or E-band?
Authors: Sambo Nicola , Correia Bruno , Napoli Antonio , Pedro João , Kiani Leily , Castoldi Piero , Curri Vittorio 
Published: August 2022

Nowadays, the fiber spectrum is only partially exploited, i.e., mainly in the C-band and more recently in the C

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L-band, where the fiber attenuation profile experiences the minimum. Thus, fiber communications technology—amplifiers, switching, transceivers, etc.—and networking solutions are mature for those spectrum bands. However, the continuous increase in traffic means that capacity saturation of the current infrastructure is looming. Taking advantage of the unused portions of the spectrum (e.g., the S- and E-bands) may be an efficient solution to accommodate an increase in traffic without installing new fibers. Research is thus investigating multi-band transmission and networking to evaluate and enable such network upgrades. Some issues need to be solved or taken into account, from the enabling technology (e.g., amplifiers in the S- or E-band are still under development) to physical layer effects previously neglected, such as stimulated Raman scattering (SRS). SRS affects wideband transmission, potentially degrading active channels. The contribution of this paper is the investigation of network upgrades for C

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L-band systems. In particular, upgrades exploiting the E- and S-bands are compared taking into account each band capacity and the effects of SRS on both new and already deployed channels (in both the C- and L-bands). A detailed analysis of the physical layer is provided also in the presence of guard bands between previously exploited bands and the bands used for upgrade. By leveraging the physical layer assessment, a networking analysis is carried out to evaluate the supported traffic increase and also the signal quality degradation due to SRS on active channels. The results suggest that upgrades to the E- and S-bands support a comparable increase in traffic. However, the exploitation of the E-band with 14 THz of guard band between the C- and E-bands may avoid detrimental effects to already active channels in the C

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L-band, suggesting this upgrade strategy can be the most effective of the two.
Concepts for millimeter wave-based detection of African trypanosomes in field-compatible liquid systems
Authors: Mueh Mario , Knieß Robert , Göringer H. Ulrich , Damm Christian 
Published: August 2022

Abstract
Human African Trypanosomiasis (HAT) is caused by the African trypanosome, a single-cell parasite that proliferates in the blood and cerebrospinal fluid of infected patients. Diagnostic measures for this pathogen are currently not sufficiently robust and reliable enough to permit effective disease control procedures. As a consequence, we suggested the development of a new sensor type, combining the selectivity of parasite-specific nucleic acid aptamers with the sensitivity of resonant electromagnetic devices to capture and detect the disease-causing organism. While we accomplished the detection of parasite cells in dehydrated specimens, here we summarize our recent progress toward electromagnetic sensors capable of uncovering parasites in liquid patient samples. We present a technique for the removal of blood cells from blood specimens and the deposition of trypanosome cells on glass microfiber membranes for dielectric spectrometry. Liquid suspensions of trypanosomes are characterized to determine the actual dielectric properties of single parasites and lastly, we present two sensor concepts optimized for the detection in liquids, along with a fabrication technique for the integration of microfluidic sample confinements.
Effect of applying air pressure during wet etching of micro copper PCB tracks with ferric chloride
Authors: Atta Raghied M. 
Published: August 2022

Abstract
Copper is an important commercial material used in various industries, especially in interconnections of microelectronics devices and printed circuit boards (PCBs). Wet etching has been widely used to machine copper tracks for producing micro-components. This process is simple and easy to implement. The selection of a suitable chemical etchant is one of the most important factors for the wet etching process, as it affects the etch rate and surface profile. Ferric chloride is considered an effective copper etchant as it possesses significant advantages. However, when etched pattern structures decrease beyond certain dimensions, ferric chloride falls short due to its isotropic nature which causes etch undercut that adds severe limitations to the process. To improve the etch rate and etch factor for the etched copper tracks, applying pressure (both positive and negative) during wet etching is suggested. Test structures with different geometry using copper spiral coils were patterned and wet etched using ferric chloride under different pressure values. The experimental study showed that the etch rate increases almost linearly with increasing pressure. Etch factor also varies with structure geometry and increases with pressure, reaching a maximum of about 2.4 at the maximum available pressure of 50 psi.
Steuerung im Netzwerk Schule und Spitzensport. Zwischen schulischer Eigenlogik und politischer Programmatik
Authors: Bonn Benjamin , Symanzik Tino , Körner Swen 
Published: August 2022

Zusammenfassung
Verbundmodelle von Schule und Spitzensport wie die NRW-Sportschule sind als Netzwerke mit vielfältigen Akteuren und Erwartungen zu beobachten, in denen programmatische Zielvorstellungen in die Gestaltung und Durchführung von Maßnahmen und die Arbeit diverser Organisationen und Personen übertragen werden sollen. Die Herausforderung für eine zielgerichtete Steuerung des Netzwerks liegt deshalb in der Koordination des Handelns einzelner Personen und der Entwicklung systemischen Wissens sowie der Ermöglichung des Lernens des Netzwerks. Der Beitrag präzisiert das Problem der Steuerung im Verbund aus der Perspektive von Netzwerktheorie und Wissensmanagement. Empirische Erkenntnisse aus der Evaluation der NRW-Sportschule dienen als Anwendungsbeispiele der (möglichen) Bearbeitung dieser Herausforderung. Zugleich ist die Evaluation selbst als Steuerungsversuch des Netzwerks kritisch einzuordnen.
Covariant coordinate transformations and scalar-field – matter interactions
Authors: Bruce Stanley A. 
Published: August 2022

Abstract
We propose a classical Lorentz invariant model of local scalar-field - matter interactions where the zeroth component of the space-time coordinates of a particle is modified by a background Klein–Gordon field. This model is not directly explained in terms of the standard model (SM) because the CPT symmetry is generally broken with a Hermitian Hamiltonian. Our ultimate goal (which is not explored here) is to construct a quantum field theory approach to tackle the matter–antimatter asymmetry problem. To understand the basics of the theory, two examples are discussed only at the quantum mechanical level: (i) a (quantum) harmonic oscillator with the occurrence of negative-energy eigenvalues where the effective energy-masses of the ‘particle and antiparticle’ are not symmetric with respect to the non-physical zero-energy mode of the oscillator; (ii) a Dirac particle in an electromagnetic (EM) linear potential.
PENGARUH TESTIMONI DALAM PERIKLANAN
Authors: H. Utama Rd. Dian , Rosalina Feni 
Published: August 2022

Persaingan pada industri perbankan syariah cukup tinggi, kegiatan pemasaran dianggap lebih efektif untuk memperluas pangsa pasar konsumen. Upaya yang dilakukan oleh Bank Syariah Mandiri dalam meningkatkan kepercayaan pelanggan terhadap merek yaitu dengan melakukan testimoni dalam periklanan dengan menggunakan endorser adalah nasabah Bank Syariah Mandiri yang diindikasikan akan berpengaruh terhadap kepercayaan merek Bank Syariah Mandiri.Penelitian ini bertujuan untuk 1) memperoleh gambaran testimoni dalam periklanan, 2) memperoleh gambaran mengenai kepercayaan merek, 3) memperoleh model mengenai pengaruh testimoni dalam periklanan terhadap kepercayaan merek.Objek penelitian ini adalah nasabah Bank Syariah Mandiri followers @syariahmandiri.Variabel bebas dalam penelitian ini adalah testimoni dalam periklananterhadap kepercayaan merek sebagai variabel tidak bebas.Jenis penelitian yang digunakan adalah deskriptif, verifikatif, dan metode yang digunakan adalah explanatory survey dengan teknik systematic random sampling, dengan jumlah sampel 120 responden. Gambaran mengenai testimoni dalam periklanan adalah sebesar 65,3%, gambaran mengenai kepercayaan merek Bank Syariah Mandiri sebesar 72% dan teknik analisa data yang digunakan adalah path analysis dengan alat bantu software komputer SPSS 21, hasil yang diperoleh dalam penelitian menyatakan bahwa testimoni dalam periklanan berpengaruh terhadap kepercayaan merek Bank Syariah Mandiri sebesar 48,8%. Dari hasil penelitian terhadap pengujian hipotesis dapat diketahui bahwa testimonidalam periklananmemiliki pengaruh baik secara parsial maupun simultan terhadap kepercayaan merek.Berdasarkan hasil penelitian melalui analisis jalur terdapat pengaruh yang signifikan dari ketiga dimensi testimoni dalam periklanan yaitu 1) source credibility, 2) source attractiveness dan 3) source power terhadap kepercayaan merek Bank Syariah Mandiri. Pembentuk kepercayaan merek adalah brand intention dan brand reliability.Pengaruh kedua variabel ini memiliki pengaruh yang signifikan baik secara simultan maupun parsial.Penulis merekomendasikan agar Bank Syariah Mandiri lebih mempertimbangkan dalam pemilihan endorser/ sumber pendukung testimoni sehingga dapat meningkatkan kepercayaan merek Bank Syariah Mandiri
SERVICE EXCELLENT DALAM RANGKA MEMBENTUK LOYALITAS PELANGGAN
Authors: Bastiar Zein 
Published: August 2022

Pemasaran merupakan hal yang mendasar dan penting untuk dipahami oleh perusahaan yang berkecimpung di dunia bisnis karena berhasil tidaknya perusahaan dalam mempertahankan dan mengembangkan usahanya sangat tergantung pada bagaimana cara perusahaan memasarkan produknya sehigga dapat diterima oleh pelanggan. Dalam persaingan dunia bisnis seperti sekarang perusahaan harus mengutamakan kepuasan pelanggan yang mana merupakan salah satu rahasia keberhasilan bisnis dan dapat survive bersaing dan menguasai pasar. Banyak kegagalan bisnis terjadi karena pelanggan dikecewakan sehingga mereka mencari alternatif ke produk sejenis lainnya. Konsumen makin berani untuk protes dan mengeluh bilamana pelayanan yang didapatkannya buruk. Konsumen mempunyai standar lebih tinggi terhadap pelayanan dan kepuasan yang berarti konsumen makin sulit merasa puas. Pendekatan berdasarkan kepentingan pelanggan sebaiknya dilakukan secara lebih sistematis dan efektif. Petinggi perusahaan harus mengetahui kebutuhan pelanggan dan perusahaan berusaha untuk menghasilkan kinerja sebaik mungkin serta meningkatkan kualitas pelayanan yang baik sehingga dapat memuaskan pelanggan dan produknya dijadikan sebagai tolok ukur keunggulan daya saing perusahaan.
SISTEM INFORMASI LOGISTIK DALAM PENGAMBILAN KEPUTUSAN EKSPOR IMPOR PADA REKANAN PT TWINS LOGISTIK
Authors: Imaniyati Nani 
Published: August 2022

Masalah yang dikaji dalam penelitian ini adalah bagaimana gambaran system informasi logistik yang dikembangkan pada Rekanan PT Twins Logistik, gambaran tentang pengambilan keputusan ekspor impor pada Rekanan PT Twins LogistikAspek yang diteliti dalam penelitian ini meliputi dua hal, yaitu sistem informasi logistik dan pengambilan keputusan ekspor impor. Indikator yang digunakan untuk sistem informasi logistik adalah sarana dan prasarana, sumber daya manusia (SDM), tata kerja atau kegiatan rutin, dan output informasi. Metode penelitian yang digunakan dalam penelitian ini adalah metode deskriptif-survei eksplanasi (explanatory survey), teknik pengumpulan data dengan cara penyebaran angket, observasi dan studi literatur. Instrumen yang digunakan adalah angket model skala likert dengan analisis data yang digunakan adalah analisis koefisien korelasi.Hasil yang diperoleh adalah koefisien korelasi antara variabel X (sistem informasi logistik) dengan variabel Y (pengambilan keputusan ekspor impor) sebesar 0,480 yang dapat diartikan bahwa hubungan tersebut berada dalam hubungan yang sedang. Untuk uji hipotesis (Ha) yang menyatakan bahwa ada hubungan antara sistem informasi logistik dengan pengambilan keputusan ekspor impor di PT Twins Logistik diterima. Kesimpulannya adalah bahwa sistem informasi logistik mempunyai hubungan yang cukup erat dengan pengambilan keputusan ekpor impor yang dilakukan oleh PT Twins Logistik. Dan saran yang dapat diberikan adalah hendaknya sistem informasi logistik yang ada di perusahaan ditangani oleh orang-orang yang memang ahli dibidangnya sehingga akan mampu menciptakan sistem informasi yang bisa diandalkan.
The Impact of Vitamin D Supplementation on the IFNγ-IP10 Axis in Women with Hashimoto’s Thyroiditis Treated with Levothyroxine: A Double-blind Randomized Placebo-controlled Trial
Authors: Robat-Jazi Behrouz , Mobini Saeed , Chahardoli Reza , Mansouri Fatemeh , Nodehi Masoumeh , Esfahanian Fatemeh , Saboor-Yaraghi Ali Akbar 
Published: August 2022

Hashimoto's thyroiditis (HT) results from chemoattraction of inflammatory cells toward the thyroid gland by inducing the production of interferon-gamma (IFNγ)-induced protein 10 (IP10) by T helper (Th) 1 cells. Vitamin D may suppress the IFNγ-IP10 axis, but this new function of vitamin D has not yet been investigated in HT patients.
In an intervention and control group, patients received 50000 IU cholecalciferol or placebo every week for three months, respectively. The CD4+ T cells of 40 patients were isolated, and the mRNA expression levels of vitamin D receptor (VDR), peroxisome proliferator-activated receptors (PPAR)-α, and PPAR-γ genes were determined by real-time PCR. ELISA method was used to determine serum levels of vitamin D, tumor necrosis factor-alpha (TNF-α), IFN-γ, and IP10.
Vitamin D levels in the intervention group were significantly higher than in the placebo group after supplementation. PPAR-α and PPAR-γ gene expression levels did not differ significantly between the two groups. The serum levels of IP10, IFNγ, and TNF-α decreased significantly in the vitamin D group, as well as in the placebo group.
During this study, vitamin D levels significantly increased in the intervention group and inflammatory factors decreased. Based on the similar results obtained in the placebo group, further studies with larger sample sizes and longer intervention times are recommended.
A Study of Autoantibodies Against some Central Nervous System Antigens and the IL-35 Serum Level in Schizophrenia
Authors: Soltani Marziyeh , Beshkar Pezhman , Mokhtarian Kobra , Anjomshoa Maryam , Mohammad Rezaei Mina , Azadegan-Dehkordi Fatemeh , Mirzaei Yousef , Majidi Jafar , Bagheri Nader 
Published: August 2022

Schizophrenia (SCZ) is a debilitating mental disorder with various causes involving complex interactions between genetic factors and environmental agents. The immune system plays a vital role in the pathology and function of the nervous system. Interleukin 35 (IL-35) is a regulatory and anti-inflammatory cytokine that can prevent autoimmune and inflammatory diseases. This study aimed to investigate the role of autoantibodies against some central nervous system (CNS) antigens and IL-35 serum levels in patients with Schizophrenia.
This case-control study involved 80 participants. The serum levels of IL-35 were measured by enzyme-linked immunosorbent assay and the autoantibodies in the CNS by indirect immunofluorescence assay (IFA).
The serum levels of IL-35 were decreased in patient groups compared to healthy subjects. Autoantibodies against N-methyl-D-aspartate receptor (NMDAR) and myelin-associated glycoprotein (MAG) were positive in 15% (6/40) and 7.5% (3/40), respectively; however, no antibodies against myelin, aquaporin-4 (AQP4), myelin oligodendrocyte glycoprotein (MOG), We found that decreased serum IL-35 levels and the existence autoantibodies against NMDAR antigen may contribute to the pathogenesis of SCZ.
Occupational Chronic Hand Dermatitis in Hospital Environment Successfully Treated with Dupilumab: A Case Report
Authors: Gan Hui , Gao Ya-dong 
Published: August 2022

Duplilumab is approved to treat mild to moderate atopic dermatitis. It is unclear, however, whether Dupilumab is effective for occupational hand eczema. In this article, we describe a 29-year-old nurse who developed severe hand eczema after working in a hospital for 6 years and received inadequate relief from routine treatment. Duplilumab was administered to the patient with great results.
Resenha da obra de Katherine Merseth, Desafios reais do cotidiano escolar brasileiro
Authors: Pessoa Amanda Raquel , Farias Isabel Maria Sabino de 
Published: August 2022

O trabalho trata-se de uma resenha sobre o livro Desafios reais do cotidiano escolar brasileiro: 22 dilemas vividos por diretores, coordenadores e professores em escolas de todo o Brasil. Colaboraram para a construção da obra o Instituto Península, o Instituto Singularidades e o David Rockefeller Center for Latin American Studies (DRCLAS), da Universidade de Harvard, tendo como organizadora Katherine Klippert Merseth, professora sênior na Faculdade de Educação da Universidade de Harvard. É uma coletânea de casos de ensino, narrativas capazes de inspirar reflexões sobre problemáticas contemporâneas da Educação ao examinar e discutir possibilidades educativas, bem como contribuir para o aprimoramento profissional dos professores.