bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nuclear Structure of Ce Nuclei within Interacting Boson Model-2
Authors: Sabbar Ali N. , Abood Saad N. 
Published: February 2022

Using the Interacting Boson Model-2 (IBM-2), we determined the most appropriate Hamiltonian for the current calculations of energy levels and electromagnetic transition probability values of 124-138Ce nuclei with a mass around A=140 in this study. We estimated energy levels and electromagnetic values and mixing ratios (E2/M1) for a number of transitions in 124-138Ce isotopes using the best fitted values of parameters in the IBM-2 Hamiltonian. When the results were compared to the experimental data, they were found to be in good agreement.
Comparison of Oral Health Status and Treatment Needs in Autistic and Non-Autistic Children
Authors: Kumar A. C. Vinod , Krithika Chandrasekaran , Sridhar Chitathoor , Praveena N. M. 
Published: February 2022

Background: Dental treatment need is identified as the greatest neglected health need of children with developmental disabilities. The most commonly known developmental disorder is autism, and there is a recent increase in the diagnosis of autism cases. The aim of this study is to bring to light that providing quality dental care and inculcating dental education programmes can significantly improve the oral conditions of institutionalized autistic children, thereby improving their lifestyle.
Materials and Methods: The study conducted an institutionally based case-control study on 50 children with autism, selected from two special schools in Chennai, India. The total number of decayed, missing, and filled teeth was assessed for the institutionalized autistic group undergoing dental education programme and the non-autistic group selected from our general hospital. Oral Hygiene Index-Simplified (OHI-S) and the DMF score were also calculated for both groups.
Results: There was a statistically significant difference in OHI scores between institution trained autistic children and non-autistic controls, but we found no significant difference in decayed, missing, and filled teeth.
Conclusion: Autistic children exhibit good cooperation and good response to Dental education programmes, significantly improving their oral health conditions.
Comparing the Effectiveness and Safety of Intrathecal Dexmeditomidine and Fentanyl as an Adjuvant to Isobaric Ropivacaine.0.75 % In Lower Abdominal Surgeries: A Study Protocol
Authors: Movva Haneesha , Taksande Karuna 
Published: February 2022

Background: Spinal anaesthesia is a form of local anaesthesia, wherein conduction block of nerve roots is done with the aid of injecting a small dose of local anaesthesia into the subarachnoid space via a lumbar puncture in left lateral position in midline at L3 L4 interface. Drug is given after confirming free flow of CSF. Local anaesthetics work for a short duration and adjuvants are used for prolongation of postoperative analgesia. Ropivacaine, a brand new amide local anaesthetic, accepted via FDA IN 1997 and using it extensively in India since 2009. Ropivacaine due to its excessive Pka and decreased lipid solubility has received popularity. This study has been planned to compare the effects of injection Dexmedetomidine & injection Fentanyl as an Adjuvant to Intrathecal isobaric Ropivacaine 0.75% for lower abdominal surgeries.
Materials and Methods: This will be a Comparative Experimental Prospective Study conducted at Anesthesiology department of AVBRH, Wardha. 80 patients will be randomized into two groups. One group will receive 3 ml of 0.75 percent isobaric ropivacaine with dexmedetomidine 10 mcg (Group RD). Another group will receive 20 mcg of fentanyl (Group RF) intrathecally for lower abdominal surgeries. Data on block characteristics, hemodynamic changes, and side effects will be collected and compared for the two groups.
Expected Results: Clinically significant results are expected in terms of mean time needed and Mean of total sensory block length in Group RD compared to Group RF.
Conclusion: Addition of 10μg dose of dexmedetomidine to 3ml of 0.75 percent isobaric ropivacaine produces earlier sensory blockade, prolonged sensory and motor blockade and improved sedation and post-operative analgesia.
Quantitative Analysis of Gross Morphology of Placenta in Normal and Hypertensive Patients
Authors: Yadgire Geetanjali U. , Rawlani Shobha S. , Sawal Anupama 
Published: February 2022

Background: Placenta is an important organ and the growth and development of fetus is dependent on it. The different pregnancy complications as antepartum haemorrhage, postpartum haemorrhage, coagulopathy etc. in mothers and IUGR (intrauterine growth retardation), prematurity etc. in foetus are reflected in the placenta & are associated with pregnancy induced hypertension (PIH) . They form the major causes of maternal and fetal mortality & morbidity.
Objectives: Quantitative analysis of the changes in gross morphology of placenta in normal and hypertensive pregnancies.
To study the resultant effect on the foetal outcome.
Material & Methods: We had taken 100 placentas of normal & hypertensive group patients each for study .We collected them from the labour room & operation theatre of Dept. of Obstetrics & Gynaecology of our medical college. Gross morphological features of placentas like size, weight, no. of cotyledons , areas of infarction, retroplacental clot, calcification and insertion of umbilical cord etc. were noted and simultaneously the histological study was also done.
Observations & Results: The gross morphological parameters like diameter, size, surface area, number of cotyledons and weight were reduced in hypertensive placentas than normal placentas while areas of infarction, retroplacental clot, calcification were more in hypertensive placentas than normal placentas. (p<0.005) The observed differences were statistically significant.
Comparative Analysis of Bone Regenerative Potential of Simvastatin Vs Platelet Rich Plasma in Mandibular Third Molar Extraction Socket: A Study Protocol
Authors: Malu Suraj S. , Hingnikar Pawan 
Published: February 2022

Background: Third Molar Extraction is a treatment used by oral and maxillofacial surgeons in which distal bone loss to the second molar is a major concern due to consequences such as pain, mastication difficulty, and pocket development. Platelet -Rich Plasma (PRP), a novel adjunct to promote bone regeneration. The method of its preparation is cumbersome and need a costly centrifuge machine. Hence many studies have been conducted to find an effective alternative to Autologous PRP. Statins have also proved effective in inducing bone regeneration of which Simvastatin has been more effective.It can also be used in immediate implant cases where faster and better bone healing is necessary for osseointegration.
Aim: To assess the effectiveness of simvastatin and PRP in regenerating bone in third molar extraction sockets.
Materials and Methods: All together 15 patients will be selected with identical bilateral third molar impaction. All the patients will be divided into two groups of simvastatin and PRP.
Expected Results: If the results prove significant, Simvastatin can be used as an osteoinductive agent for bone healing.
Conclusion: If the outcomes favor the bone regeneration potential of Simvastatin to be equivalent or superior than PRP, then Simvastatin can be used for osteoinduction in Third Molar Extraction socket or other small bony defects.
Incidence of Aberrant Right Subclavian Artery in General Population
Authors: Raj S. Vishnu , Raja Sam , Mendu Yatin , Yarlagadda Sneha , Rajan Seena Cheppala 
Published: February 2022

Objective: The existence of an anomalous right subclavian artery is the most significant aortic arch defect. Dysphagia, wheezing, stridor, and other symptoms may occur if this vessel pressures the neighbouring structures. The goal of this study is to find out how common ARSA is based on CT scans of the thorax and neck (plain and contrast).
Method: Between January 1st and December 31st, 2020, 1122 patients had CT Thorax/neck scans, and the data were evaluated. The origin of the ARSA, the vessel's path, and the Kommerell diverticulum were all assessed. We looked at the literature to see how important ARSA is in clinical practise.
Results: ARSA was found in eight of 1122 patients. All of the ARSAs in these eight individuals began at the posterior part of the aortic arch and travelled via the retroesophageal path to the thoracic outlet. All eight ARSA were found in the front part of the thoracic vertebral bodies, from the first to the fourth.
Conclusion: Other clinical symptoms such as dysphagia, dyspnea, retrosternal discomfort, cough, and weight loss must be differentiated from compression of surrounding tissues by an abnormal right subclavian artery.
A Study of Histopathological Spectrum of Lesions in Cervix Biopsies in a Tertiary Care Hospital
Authors: Kerthi K. S. , Chander Vimal 
Published: February 2022

Introduction: Uterine cervix is prone to numerous infections, inflammations and malignancy. cervical cancer is the most common cancer in women which may be detected early with the aid of doing screening examination.
Aim: This study was done to examine and analyze the histopathological lesions of cervix and to evaluate the frequency of these lesions, to understand the spectrum of various neoplastic and non-neoplastic cervical lesions and to study the incidence and frequency of various cervical lesions in different age groups so as to target them for various diagnoses, early detection and raising awareness.
Study Design: Retrospective cross-sectional study.
Place and Duration of Study: The study was conducted for a duration of 15 months from January 2019 to March 2020 retrospectively. Different types of pathological lesions in cervix were analyzed in the department of Pathology at Saveetha medical college.
Methodology: This study consists of a total of 534 cases, Patients’ available clinical profile and the histopathologic diagnosis were noted from the registers and all cases of cervical biopsies over the above time period were included for this study. The diagnoses were then classified into non-neoplastic, pre-invasive and invasive lesions and statistical analysis was done using IBM SPSS statistical package version 23 and JASP statistical package version 0.13.1.
Results: In this study, 534 cases are studied. The most common age group associated with the occurrence of cervical lesions were 41-50 years, among them the most common non-neoplastic lesion was chronic cervicitis and the most common malignant lesion observed was squamous cell carcinoma.
Conclusion: In this study, non-neoplastic lesions were more common as compared to neoplastic lesions, adding to that chronic cervicitis being the most common. Histopathological examination and tissue biopsy help in the early detection and diagnosis of malignant and premalignant conditions. These prognostic measures could help the patients to have better treatment options and can at times reduce the fatality rate.
A Prospective Study on the Functional and Radiological Outcomes of AO Type C Distal Humerus Fractures in Adults Treated Surgically with Bicolumnar Fixation
Authors: Yadav Rohit Sunil , Srinivasan . , Vasanthkumar C. 
Published: February 2022

Purpose: To study the functional and radiological outcomes of AO type C distal humerus fractures (DHFs) in adults treated surgically with bicolumnar fixation.
Methods: A prospective study of 30 adult patients with AO/OTA type C fractures of the distal humerus treated operatively with bicolumnar fixation between September 2018 to December 2020 at Sree Balaji Medical College & Hospital, Chennai was performed. Closed distal humerus fractures with intra-articular extension were fixed with bicolumnar plating, with orthogonal or parallel configuration of plate fixation decided intra-operatively. This was achieved in all patients after performing an olecranon osteotomy for better exposure of the fracture site, which was later fixed with either CC screws or K-wires with tension band wiring. The functional and radiological outcomes in this study group were assessed on regular post-operative follow-up. The Mayo Elbow Performance Score (MEPS) was used to evaluate the functional outcomes in our patients.
Results: The mean age of the patients was 44 years, with 18 (60%) males and 12 (40%) females in the study. The right-sided elbow was more frequently involved (57%) in our study. The most common mode of injury was Motor Vehicle Accident (MVA) (14 cases; 47%), while domestic fall contributed to 10 (33%) cases. Fall from height and direct trauma to the elbow made up the rest of the cases, with a 10% incidence each. A majority of cases (22 cases; 73%) showed radiological union between 12-16 weeks post-operatively, whereas 8 cases (27%) united between 17-21 weeks. The Mayo Elbow Performance Score (MEPS) used to assess the functional outcome showed excellent results in 25 (83%) cases, good and fair results in 2 (7%) cases each, and a poor outcome in 1 (3%) case.
Conclusion: For satisfactory results in intraarticular fractures of the distal humerus treated with bicolumnar plating, thorough pre-operative planning, posterior surgical approach with adequate exposure via olecranon osteotomy, anatomical inter-fragmentary stabilization by dual plating, and early post-operative mobilization with physiotherapy are important steps to be followed.
Knowledge, Attitude and Practice about Pre-Analytic Errors of Blood Transfusion among Interns
Authors: Monisha K. , Hariharan A. , Kumar Suresh , Chitra S. 
Published: February 2022

Aim: The aim of this study is to evaluate knowledge, attitude and practice about pre-analytic errors among interns. This elicits the efficiency of interns on the basis of knowledge, attitude and practice in blood transfusion and to analyse about the pre-analytic errors in blood transfusion.
Study Design: A cross sectional study
Place and Duration of Study: Department of Transfusion Medicine, Saveetha Medical College Sriperumbudur, between January 2020 to August 2020.
Methodology: The prospective study will be done by distributing online questionnaire. From the questionnaire the interpretation of pre-analytical errors will be analysed statistically.
Results: A total of 150 interns in a Tertiary care teaching hospital were given the online questionnaire in which 136 interns responded and 14 were not responded and the results showed lower frequency of incidents in pre-analytic errors.
Conclusion: Though the pre analytic errors were less, the lack of knowledge among the medical staff in transfusion is obvious. Therefore, we must have the possibility of organizing regular training and follow-up activities to improve the knowledge of interns in transfusion.
Osteometric Measures of Mandible on Its Various Aspects in South Indian Dry Skull
Authors: Ranjeet Srivarsha , Premavathy Dinesh 
Published: February 2022

Introduction: Mandible is the single bone articulated with cranium forming a temporomandibular joint and it contributes to the lower jaw containing teeth. The mandible is composed of the body and the ramus.
Aim: Aim of this study is to find the distance between each parameter in different mandibles.
Materials and Methods: The present study has utilized 30 south indian dry skulls from the Anatomy Department of Anatomy, Saveetha Dental college. The following parameters are taken to measure by using vernier calipers. They are the maximum distance between the mandibular incisors, mandibular inter canine, mandibular 1st premolar, mandibular molar, mandibular coronoid process, mandibular condylar process, mandibular notch on either side. The results were analysed statistically by using t-test calculator in Graph pad.
Results: From the study it was observed that the mean distance between the mandibular incisors is 15.658 ± 1.642416 , mandibular inter canine 29.0025 ± 9.04636, mandibular 1st premolar 40.746 ± 2.543341, mandibular molar 62.076 ± 3.4988, mandibular coronoid process 85.8735 ± 5.10615, mandibular condylar process 103.013 ± 3.794, mandibular notch on either side 88.368 ± 3.5832 (Table 1 & Figs. 1-6).
Conclusion: The present study thus concluded that the morphometric analysis of the mandible is of utmost importance in determining the gender, anatomical studies, clinical and anthropometric studies.
Correlation of IDH1-(R132H) and ATRX Expression with the Histopathological Grades of Glial Tumours: A Study Protocol
Authors: Jha Pooja , Shukla Samarth , Vagha Sunita , Kadu Ravindra P. 
Published: February 2022

Background: Brain tumors contribute significantly to morbidity as they can lead to neurological deficits, mental alterations and have a poor survival rate. The utmost frequent varieties of primary brain tumors are gliomas. Modern data on permeated gliomas showcased persistent modification within the involved genes in the chromatin remodeling routes such as α-thalassemia/mental-retardation syndrome-X-linked gene (ATRX) and IDH1. Till date, the authenticity of ATRX in predicting isocitrate dehydrogenase (IDH1) mutations in gliomas, is unclear. This study attempts to assess the correlation between IDH1 mutation and ATRX expression and histopathological grading in glial tumors.
Methods: This will be a retrospective analytical study conducted in Pathology Department, of JNMC, Wardha in coordination with the Department of Neurosurgery, AVBRH. This study will include histochemical analysis of 45-50 resected specimens of confirmed cases of Glial tumours. The correlation between IDH1 mutation and ATRX expression with the histopathological grades in glial tumors will be analysed in comparison with the present-day molecular advances.
Results: Significant correlation between IDH1 mutation and ATRX expression with the histopathological grades is expected.
Conclusion: Conclusion will be drawn on careful analysis of data.
In Silico Molecular Docking Analysis of the Potential role of Reticuline and Coclaurine as Anti-colorectal Cancer Alkaloids
Authors: Al-Zahrani Maryam H. , Alghamdi Rana A. 
Published: February 2022

Background: Colorectal cancer (CRC) is a serious global epidemic, being the third most prevalent cancer worldwide, finding novel treatment alternatives for CRC is thus of the greatest importance. The atomic level interaction between a tiny molecule and a protein can be represented using molecular docking. Molecular docking is critical for visualizing ligand-protein interactions at the atomic level highlighting our knowledge of ligands behavior, which aids in the development of structure-based drugs.
Methods: We used molecular docking to investigate the anticancer activity for two main ligands (reticuline and coclaurine) and four potential anticancer receptors (TNIK, VEGFR, EGFR and AKT2). Protein Data Bank provided the 3D structures of the receptor proteins, iGEMDOCK and AutoDock vina program were used for molecular docking.
Results: Reticuline had the best docked postures and the highest interactive energy with CRC receptors: TNIK, VEGFR, EGFR and AKT2 with the following binding energy; -96.7, -117.8, -120.2, and -108.3 kcal/mol accordingly.
Conclusion: According to this study, the investigated ligands were successfully docked onto reticuline and coclaurine ligands for drug interaction studies, the calculated binding energy demonstrate their importance as an anti-carcinogenic target. The current findings lay the groundwork for further research into reticuline and coclaurine as a potential CRC therapeutic option.
Modeling the Factors Associated with BMI among Type 2 Diabetes Mellitus Patients: A Hybrid Model Approach
Authors: Ghazali Farah Muna Mohamad , Ahmad Wan Muhamad Amir W. , Adnan Mohamad Nasarudin , Samsudin Norsamsu Arni , Aleng Nor Azlida , Noor Nor Farid Mohd , Ibrahim Mohamad Shafiq Mohd , Shamsudin Nurul Hidayah Binti , Selvaraj Siddharthan 
Published: February 2022

Background: Diabetes mellitus is a chronic illness that results in abnormally high blood sugar levels. It can result in a range of complications.
Objective: The purpose of this study is to present an ideal variable selection strategy utilizing proven Multiple Linear Regression (MLR) models and to validate the variable using Multilayer Perceptron Neural Network (MLP) models. This will validate a factor linked with body mass index (BMI) status in individuals with dyslipidemia and type 2 diabetes mellitus.
Materials and Methods: Thirty-nine patients were selected from Hospital Universiti Sains Malaysia (USM). Many variables, including BMI, gender, age, race, coronary heart disease status, waist circumference, alanine transferase, triglycerides, and dyslipidemia, were assessed in this retrospective analysis using advanced computational statistical modelling approaches. This study uses R-Studio software and syntax. Each sample's statistics were generated using a hybrid model combining bootstrap and multiple linear regression.
Results: R's statistical approach demonstrates that regression modelling is superior to R-squared performance. The hybrid model may better predict the outcome by separating the datasets into a training and testing set. The well-known bootstrap-integrated MLR technique was used to determine the validity of the variables. The eight variables examined in this case are gender ( : -2.329; p < 0.25), age ( : -0.151; p < 0.25), race ( : 2.504; p < 0.25), coronary heart disease status ( : -0.481; p < 0.25), waist circumference ( : 0.572; p < 0.25), alanine transferase ( : 0.002; p < 0.25), triglycerides ( : 0.046; p < 0.25), and dyslipidemia ( : 30.769; p < 0.25). There is a linear model that has a 9.019188 MSE.lm in this case.
Conclusion: This study will develop and extensively evaluate a novel hybrid approach combining bootstrapping and multiple linear regression. The R syntax for this procedure was chosen to ensure that the researcher comprehends the example completely. The statistical methods used to conduct this research study using R show that regression modelling is better than R-squared values for the predicted mean squared error. Thus, the study's conclusion shows that the hybrid model technique is superior. This vital conclusion helps us better understand the hybrid method's relative contribution to the result in this case.
Effectiveness of Self-instructional Module on Knowledge Regarding Healthy Sleep Hygiene Habits on Quality of Sleep, among Arthritis Patients
Authors: Sakharkar Sheetal , Sharma Ranjana , Ankar Ruchira , Tembhare Vaishali , Raut Arati , Meshram Khushabu , Mude Dinesh V. 
Published: February 2022

Aim of the Study: To assess the effectiveness of self-instructional module on healthy sleep hygiene habits on quality of sleep, among arthritis patients.
Study Design: The design that will be used in the study is One Group Pre Test Post Test research design.
Methodology: A study used a pre-test post-test design with no control group and a pre-experimental design. The study will be conducted during December 2021 to May 2021.The impact of self-instructional module on healthy sleep hygiene habits on quality of sleep, among arthritis patients will be assessed using the purposive sampling technique. In this study Evaluatory research approach will be used. Selected 140 arthritis patients will be assessed primarily for knowledge by giving structured questionnaires regarding healthy sleep hygiene habits and then self-instructional module on healthy sleep hygiene habits on quality of sleep, will be given to the selected sample developed by researcher as intervention.
Expected Results: To assess the effectiveness of self-instructional module on healthy sleep hygiene habits on quality of sleep, among arthritis patients. In this study self-instructional module on healthy sleep hygiene habits on quality of sleep will be useful in improving the arthritis patient’s knowledge.
Conclusion: The conclusion will be drawn from the results and will be published in per review journal.