bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of Effective Family Planning Communication Among Couples in Harar, Eastern Ethiopia: A Community Based Matched Case-Control Study
Authors: Zelalem Desalew , Worku Alemayehu , Dessie Yadeta 
Published: April 2022

Abstract
IntroductionEffective spousal family planning communication is determined by various socio-economic, demographic, family planning knowledge and attitude, and exposure of couples to family planning message on media. Women' equality with men in terms of educational status, relative power of each spouse and women's social and economic vulnerability dictates couples' communication on family planning and other reproductive health issues. MethodsA community based matched case-control study was conducted in twelve kebeles of Harar Urban Health and Demographic Surveillance System. A total of 1010 cases (married couples) and 1010 controls (married couples) of whose wives were in the reproductive age participated in the study. The selection of the study participants was made using simple random sampling.ResultsIn this study, husband's desire for more children (aOR=0.2; 95%CI: 0.11, 0.41), wives desire for more children (aOR=0.1; 95%CI: 0.06, 0.34) and fewer children (aOR=0.4; 95%CI: 0.19, 0.84), couples' approval of family planning use (aOR=2.3; 95%CI: 0.65, 8.37) and women's family planning counseling by health workers (aOR=2.1; 95%CI: 1.12, 3.8) were significantly associated with effective spousal family planning communicationConclusionIn conclusion the results revealed that policies and programs aimed at promoting family planning should strengthen family planning information, education and communication activities to enable couples concord on their desired number of children and develop positive attitude towards family planning.
Method of Bidirectional Green Wave Coordinated Control for Arterials Under Asymmetric Release Mode
Authors: ji lina , cheng wei 
Published: April 2022

Abstract
The existing coordinated control methods of green wave are more complicated and less operable, which are mainly applicable to intersection groups with symmetrical entrance release mode. Based on engineering practice, a new method of bidirectional progression green wave coordination control is presented by designing particular overlapping phases on the basis of NEMA dual-ring phasing configuration. According to the characteristics of asymmetric release mode and the requirements of green wave coordinated control, the overall optimization designs of phase sequence combination and offset were carried out, and the influences of cruising speed and residual queues at red light on offset were considered, and then the classical bidirectional green wave graphic method was optimized. Based on the investigation data of the intersections group of Ziwu Road in Qujing city, bidirectional green wave designs were conducted under both symmetric and asymmetric release mode. The results show that the latter approach not only improves the bandwidth of bidirectional green wave band effectively, but also reduces the average delay and the average number of stops on the main road.
Downregulation of Linc00173 increases BCL2 mRNA stability via the miR-1275/PROCA1/ZFP36L2 axis and induces acquired cisplatin resistance of lung adenocarcinoma
Authors: Tao Xingyu , Li Yang , Wu Liyang , Fan Songqing , Xin Jianyang , Su Yun , Xian Xiaoyang , Huang Yingying , Huang Rongquan , Fang Weiyi , Liu Zhen 
Published: April 2022

Abstract
Background
LINC00173 had been reported as a cisplatin (cis-diamminedichloroplatinum, DDP) chemotherapy-resistant inducer in small cell lung cancer (SCLC) and lung squamous cell carcinoma (LUSC). Here, reversed data was displayed for LINC00173 as a DDP chemosensitivity-inducing factor in lung adenocarcinoma (LUAD).
Methods
LINC00173 was screened from GEO databases (GSE43493), then In situ hybridization and qRT-PCR were used to detect the expression level of LINC00173 in tissue samples and LUAD cell lines. Moreover, colony formation assay, cell viability and IC50 assays, flow cytometry, nude mouse tumor xenograft model were individually performed to certificate the effect of LINC00173 on LUAD in vitro and in vivo. The relationships between miR-1275 and LINC00173 or PROCA1 were identified by dual-luciferase reporter assay, as well as c-Myc binding with LINC00173 promoter. The direct binding of miR-1275 with LINC00173 was investigated c by RAP. ZFP36L2 protein bind to the 3’UTR of BCL2 was confirmed by RIP. The apoptosis related proteins (including c-CASP3, c-PARP and BCL2) and related signal proteins were analysed by Western blot.
Results
LINC00173 down-regulation in DDP-resistant LUAD patients was correlated with poor prognosis. Further, LINC00173 expression was significantly reduced in DDP-resistant LUAD cells and DDP-treated human LUAD tissues. Suppressed LINC00173 in LUAD cells enhanced DDP chemoresistance in vivo and in vitro, while restored LINC00173 in DDP-resistant LUAD cells markedly regained chemosensitivity to DDP. Mechanistically, DDP-resistant LUAD cells activated PI3K/AKT signal and further elevated c-Myc expression. C-Myc binds to the promoter of LINC00173 to suppress its expression. Reduced LINC00173 attenuated the adsorption of oncogenic miR-1275 and thus down-regulated the expression of miR-1275-target gene PROCA1. PROCA1 played a potential tumor-suppressive role inducing cell apoptosis and DDP chemosensitivity via recruiting ZFP36L2 to bind to the 3’UTR of BCL2, reducing the stability of BCL2 mRNA and thus activating apoptotic signal.
Conclusion
Our study demonstrated a novel and critical role of LINC00173 which was transcriptionally repressed by DDP activated PI3K/AKT/c-Myc signal in LUAD and thus promoted DDP-acquired chemotherapeutic resistance via regulating miR-1275 to suppress PROCA1/ZFP36L2-induced BCL2 degradation, leading to apoptotic signal reduction.
The investigation of mid-layer cracks effects on the performance of bimorph piezoelectric energy harvester with silicon substrate
Authors: Jamshiddoust Asghar , Farrokhabadi Amin 
Published: April 2022

Abstract
Cracks are common faults in micro-electromechanical structures that affect the performance and dynamic behavior of the structure. Cracks can change the stiffness of the structure and parameters like resonance frequency, voltage and output power and after a specific time could lead to failure of that structure. Thus, diagnosis and identification the cracks in the structure will be very important. In the present study, a semi-analytical approach for the analysis of through the thickness cracks in the bimorph piezoelectric energy harvesters is proposed and both the stiffness reduction and changes in the capacitance of the structure due to through the thickness cracks are considered. From micromechanical point of view, a crack density based stress transfer method is employed for calculation of stiffness reduction due to crack formation in the middle layer. Analytical results of crack effects in mid-layer of a bimorph are derived by employing the Euler-Bernoulli beam theory assumptions and are validated via FEM. The effects of these defects on the mechanical parameters like resonance frequency, as well as electrical parameters like the output electrical power are discussed. It is observed that the presence of cracks in the mid-layer of bimorph piezoelectric energy harvester causes the decrease in its resonance frequency and the increase in the voltage and output power which is a sign of device failure. This work will provide an easy way for MEMS users to know some kinds of defects just only by monitoring the performance of the harvester.
The prognostic value of admission blood urea nitrogen in patients undergoing percutaneous coronary intervention with rotational atherectomy: a cohort study
Authors: Liao Hanhui , Deng Tianhua , Yang Renqiang 
Published: April 2022

Abstract
Objective
In patients undergoing percutaneous coronary intervention (PCI) with rotational atherectomy (RA), the relationship between blood urea nitrogen (BUN) and the post-discharge major adverse cardiovascular events (MACE) is unknown. The aim of this study was to explore whether there exists an association between admission BUN and prognosis in patients undergoing PCI with RA.
Methods
A total of 94 consecutive patients who underwent PCI with RA were included in this retrospective study. Based on admission BUN, the patients were divided into two categories: high (> 7.7 mmol/l) and low (≤ 7.7 mmol/l) BUN groups. The patients were followed-up for adverse clinical outcomes after discharge and the median follow-up time was 1.4 years (interquartile range [IQR] 0.8–3.0).
Results
Patients in the high BUN group showed older age, worse NYHA classification, worse renal function (creatinine, eGFR, uric acid) and higher homocysteine levels than those in the low BUN group. During the period of follow-up, patients in the high BUN group had higher rates of MACE (71.43% vs. 37.88%; p = 0.003) and readmission for cardiovascular diseases (64.29% vs. 31.82%; p = 0.003) than patients in the low BUN group. This difference persisted after the Cox multivariate regression analysis.
Conclusion
Elevated BUN on admission is an independent marker of MACE among patients undergoing PCI with RA.
Exposome Approach for Identifying Modifiable Factors for the Prevention of Colorectal Cancer
Authors: Chen Nanqian , Liang Hailun , Huang Tao , Huang Ninghao 
Published: April 2022

Abstract
Previous studies have shown certain exposure factors (such as lifestyle and metabolism) are associated with colorectal cancer (CRC) events. However, the application of the exposome theoretical frame and the extent to which the exposome domain can modulate the risk of CRC remain unknown. Our study aimed to construct valid exposome measurements and examine the relationship between exposome counts and the risk of CRC. This study included 273,342 individuals in the UK Biobank. We used exploratory factor analysis to identify a valid construct of exposome factors. We then summed the exposome counts within each domain. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of CRC risk related to the exposome factors and counts. During an 8.69 year median follow-up, 8642 CRC cases were identified. Seven domains were extracted from 18 variables, including air pollution, noise pollution, ecosystem, lifestyle, tobacco and alcohol use, social economics, and social support. The Cox model results showed that the ecosystem was positively related to the reduced CRC risk (HR=0.97; 95% CI: 0.949–0.991). Similar results were also found among the domains of healthy lifestyles (HR=0. 873; 95% CI: 0.854–0.893), and no tobacco and alcohol use (HR=0.880; 95% CI: 0.862–0.899). The disadvantageous social economic (HR=1.068; 95% CI: 1.046–1.090) and insufficient social support domains (HR=1.067; 95% CI: 1.042–1.094) were associated with an increased risk of CRC. Similar risk trends were also observed across the exposome count groups with CRC incidence. Our findings suggest that certain exposure domains are related to the incidence of CRC. Ecosystem, lifestyle, and social factors can be incorporated into prediction models to identify individuals at high risk of CRC.
A novel approach using incremental multi modal oversampling for data stream mining
Authors: Anupama N , Sankar V Ravi , Sudarson Jena 
Published: April 2022

Abstract
Knowledge discovery process is to provide effective rules from the existing data. The process of finding knowledge is a complex task when the data source is in the form of data streams and in fact the data source of class imbalance nature. To find the opt solutions for those problems research proposals are formulated by many researchers. The some of the unsolved problems in the literature for the above said problem is for very large data sources of data streams with class imbalance nature. In this paper, a novel proposal for class imbalance large data streams is presented with novel techniques of oversampling and a unique multi modal filtering technique and oversampling strategy as Multimodal Increment Over Sampling for Data Streams (MIOSDS) for efficient implementation of proposal for a better solution. The experimental simulations are conducted on three large datasets with different domains. The results generated are good compared with benchmark evaluation metrics.
Overexpression of tomato SlTpx improves salt stress tolerance in transgenic tobacco plants by scavenging H2O2
Authors: Qiao Shengtai , Feng Yang , Yan Jinping , Li Kunzhi , Xu Huini 
Published: April 2022

Abstract
H2O2 is an important signaling molecule that involved in multiple physiological metabolic activities in plants. Excess H2O2 can destroy biological macromolecules to poison the cell. Thioredoxin peroxidase (Tpx) plays an important role in protecting plants from oxidative damage by clearing the H2O2. In this study, tomato Tpx (SlTpx) gene was cloned and bioinformatic analysis was done. The mRNA transcript level of SlTpx in tomato roots and leaves were increased significantly after NaCl stress treatment. SlTpx overexpression transgenic tobacco plants were obtained to study its function under NaCl stress. The seed germination rate of SlTpx overexpression plants was higher than that in wild plants (WT) under NaCl treatment. The ROS and NO accumulation in transgenic tobacco root tips were all less than in WT under NaCl stress. Meanwhile,compared with salt stress, transgenic plants had low ROS accumulation, high antioxidant enzyme activity and high proline and soluble sugar content. The Na+ metabolism genes expression was higher in transgenic plants than the WT. The SlTpx transgenic plants showed higher tolerance to H2O2 and MV treatment, compared with the WT. Besides, the growth of prokaryotic strain of SlTpx was better than the pET28a strain with H2O2 treatment. The above results indicate that the SlTpx gene improves the plant salt tolerance by scaveging H2O2.
Predicting maximum force in SPIF for different materials
Authors: Schreiber Rafael Gustavo , Mondo Lucas Santos Savi , Daleffe Anderson , Schaeffer Lirio 
Published: April 2022

Abstract
Knowing the importance of predicting acting forces during the formation process, our research has conducted 27 SPIF experiments in hyperboloid format, followed by Finite Element Method (FEM) simulations to validate the measurements found in order to determine regression equations to estimate maximum axial force in the SPIF process according to material type, sheet initial thickness and tool radius. With that data, we created a general multiple regression model and three other independent models (one for each material). After the experiments, we were able to identify that the maximum axial force increases according to increase in tool radius, plate initial thickness and yield constant values, as well as according to the decrease in strain-hardening exponent. The FEM simulations are in accordance with the experimental values found, and the general regression model has proven to be efficient to describe results, with a maximum percentage error of 11.5% in the regression equation. In the independent regression models, precision was increased and the maximum percentage error in the equations was of 10.9%.
Probing Notch1-Dll4 Signaling in Regulating Osteogenic Differentiation of Human Mesenchymal Stem Cells using Single Cell Nanobiosensor
Authors: Wang Shue , Zhao Yuwen , Yang Rui , Bousraou Zoe , Richardson Kiarra 
Published: April 2022

Abstract
Human mesenchymal stem cells (hMSCs) have great potential in cell-based therapies for tissue engineering and regenerative medicine due to their self-renewal and multipotent properties. Recent studies indicate that Notch1-Dll4 signaling is an important pathway in regulating osteogenic differentiation of hMSCs. However, the fundamental mechanisms that govern osteogenic differentiation are poorly understood due to a lack of effective tools to detect gene expression at single cell level. Here, we established a double-stranded locked nucleic acid (LNA) /DNA (LNA/DNA) nanobiosensor for gene expression analysis in single hMSC in both 2D and 3D microenvironments. We first characterized this LNA/DNA nanobiosensor and demonstrated the Dll4 mRNA expression dynamics in hMSCs during osteogenic differentiation. By incorporating this nanobiosensor with live hMSCs imaging during osteogenic induction, we performed dynamic tracking of hMSCs differentiation and Dll4 mRNA gene expression profiles of individual hMSC during osteogenic induction. Our results showed the dynamic expression profile of Dll4 during osteogenesis, indicating the heterogeneity of hMSCs during this dynamic process. We further investigated the role of Notch1-Dll4 signaling in regulating hMSCs during osteogenic differentiation. Pharmacological perturbation is applied to disrupt Notch1-Dll4 signaling to investigate the molecular mechanisms that govern osteogenic differentiation. In addition, the effects of Notch1-Dll4 signaling on hMSCs spheroids differentiation were also investigated. Our results provide convincing evidence supporting that Notch1-Dll4 signaling is involved in regulating hMSCs osteogenic differentiation. Specifically, Notch1-Dll4 signaling is active during osteogenic differentiation. Our results also showed that Dll4 is a molecular signature of differentiated hMSCs during osteogenic induction. Notch inhibition mediated osteogenic differentiation with reduced Alkaline Phosphatase (ALP) activity. Lastly, we elucidated the role of Notch1-Dll4 signaling during osteogenic differentiation in a 3D spheroid model. Our results showed that Notch1-Dll4 signaling is required and activated during osteogenic differentiation in hMSCs spheroids. Inhibition of Notch1-Dll4 signaling mediated osteogenic differentiation and enhanced hMSCs proliferation, with increased spheroid sizes. Taken together, the capability of LNA/DNA nanobiosensor to probe gene expression dynamics during osteogenesis, combined with the engineered 2D/3D microenvironment, enables us to study in detail the role of Notch1-Dll4 signaling in regulating osteogenesis in 2D and 3D microenvironment. These findings will provide new insights to improve cell-based therapies and organ repair techniques.
Transsphincteric rectal resection techniques should be considered as sphincter-sparing surgical procedures in lower rectal cancer cases with external sphincteric invasion because the invased proximal sphincteric segment can be resected
Authors: Yücesoy Ali Naki , Hamad Farid Mohamad , Polat Nedim 
Published: April 2022

Abstract
Purpose: Tumor invasion of the external anal sphincteric muscle in patients with lower rectal cancer is one of the most important contraindications for the intersphincteric resection technique, which is the most common sphincter-sparing method in lower rectal cancer surgery. The main purpose of this article is showed that in lower rectum patients with external anal sphincter invasion, the tumoral lower rectal segment can be excised together with the invaded proximal segment of the external anal sphincter muscle system using the transsphincteric rectal resection surgeries performed with combined abdominal and perineal access, and it is highlighted that they can be considered as sphincter-sparing surgical procedures in these cases.Methods: This study includes the retrospective evaluation of 4 male and 1 female patient with advanced lower rectal adenocarcinoma detected external anal sphincteric invasion on their preoperative MRI results who underwent proximal segmental sphincteric excision and sphincter-sparing rectal resection operations in transsphincteric plan after neoadjuvant chemoradiotherapy.Results: In the postoperative follow-up of patients; Perineal fistula developed in 3 patients. Anastomotic stenosis developed in 2 patients, one of whom developed a perineal fistula. No external sphincteric invasion was detected in the postoperative histopathological evaluation of 1 patient. In the anal sphincteric pressure measurements made in the postoperative period, partial decreases were observed in the resting and maximal squeezing anal pressures of the patients. In the clinical follow-up of the patients whose ileostomy was closed, it was determined that sufficient continence was achieved. One patient died at postoperative 8th month following systemic metastases occurring at postoperative 5th month.Conclusion: Invased proximal sphincteric segment can be resected by using transsphinteric rectal resection techniques in advanced lower rectal cancer cases.
Design, synthesis and characterization of a urea-bridged periodic mesoporous organosilica supporting Cu nanoparticles (Cu@APS-TDU- PMO) as highly efficient and recoverable catalyst for the synthesis of tetrazole derivatives
Authors: Valiey Ehsan , Dekamin Mohammad G. 
Published: April 2022

Abstract
In this work, a new mesoporous periodic organosilica is introduced with urea-bridges obtained by the reaction of amino group of (3-aminopropyl) triethoxysilane and 2,4-toluene diisocyanate (APS-TDU-PMO). The obtained PMO-APS-TDU was found to be an appropriate support for loading of Cu(II) nanoparticles to afford Cu@APS-TDU-PMO. Uniformity and mesoporosity of both synthesized nanomaterials including PMO-APS-TDU and Cu@PMO-APS-TDU were characterized by different techniques such as FTIR, EDX, TGA, XRD, FESEM, BET, and TEM. Furthermore, the prepared Cu@APS-TDU-PMO was also used, as a heterogeneous and recyclable catalyst, for the synthesis of tetrazole derivatives through cascade condensation, concerted cycloaddition and tautomerization reactions. Indeed, the main advantages of this Cu@APS-TDU-PMO is its simple preparation and high catalytic activity as well as proper surface area which enable it to work under solvent-free conditions. Also, the introduced Cu@APS-TDU-PMO heterogeneous catalyst showed good stability and reusability for five consecutive runs to address more green chemistry principles.
The emergence of lightning as a natural disaster in Bangladesh and its impact on household dynamics
Authors: Akther Sabrina , Rahman Md. Marufur , Rezwana Nahid 
Published: April 2022

Abstract
Lightning in recent years has become a disaster of great concern for Bangladesh due to increasing fatality, especially during pre-monsoon and monsoon seasons. This study addresses the socio-economic impact of lightning fatalities on the victims' households and delves into lightning myths, superstitions, and misconceptions. We interviewed (N=15) the households affected by lightning fatalities from 2015 to 2019 in Mymensingh, one of the worst lightning-affected districts of Bangladesh. Among the studied households (HHs), all except one were in rural areas, and almost all fatalities were male. Victims mainly were engaged in outdoor activities like farming and fishing during the lightning events. Due to the death of their primary wage earner, two-thirds of the HHs were in severe economic crisis. Children's drop out of school and early marriage of girl children were also observed due to the death of the breadwinner from lightning. We recommend a mass awareness program to change the indifferent attitude and misconceptions about lightning disasters along with introducing a suitable early warning and warning dissemination system to reduce future fatality. We also recommend increasing monetary and other support for the victim's family.