bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diversity and structure of Bettongia tropica: using population genetics to guide reintroduction and help prevent the extinction of an endangered Australian marsupial
Authors: Todd Stephanie Jean , McKnight Donald T. , Congdon Brad C. , Pierson Jennifer , Fischer Manuela , Abell Sandra , Koleck Jessica 
Published: November 2022

Abstract
Conservation translocations can restore populations and prevent extinction of threatened species. Sourcing adequate genetic diversity is an essential consideration when planning reintroductions, because it influences individual fitness and long-term persistence of populations, yet available populations of threatened species may lack diversity. We estimated population genetic parameters for one of Australia’s most threatened mammals, the northern bettong, Bettongia tropica, to select source populations for reintroduction. Individuals from sites across the species’ extant range in the Wet Tropics of north Queensland were genotyped, using 6,133 informative SNPs. We found that samples clustered into four populations: an isolated northern population at Mt Spurgeon and three connected southern populations in the Lamb Range. Most of the species’ genetic diversity was dispersed across the Lamb Range populations in approximately equal proportions. Individuals showed an isolation-by-distance effect, even over short distances within continuous habitat. Admixture of populations was high at distances < 7 km but low at distances > 11 km, and there was asymmetrical gene flow between the two closest neighboring populations. All populations had small effective sizes and experienced drift, but connectivity appears to have mitigated drift and stabilized population sizes within the Lamb Range. The Mt Spurgeon population had a very small effective population size and low genetic diversity. We use our findings to weigh up the risks and benefits of mixing sources for reintroduction, and we recommend a mixed source approach. We do not currently recommend sourcing individuals from Mt Spurgeon and conservation efforts to preserve this population are urgently required.
The way forward truly QoS aware EPON
Authors: Radivojević Mirjana , Matavulj Petar 
Published: November 2022

Abstract

In the last decade, the bit rates achieved on fiber broadband networks have increased multiple times and every new generation of passive optical network (PON) technologies must unlock more of fiber’s potential and must be backward compatible to ensure easy and iterative upgrade of operator’s networks. In this paper we present two novel dynamic wavelength (in the case of multichannel system) and bandwidth allocation models for realization of fully QoS (Quality of Service)-aware single-channel i.e. multichannel Ethernet passive optical network (EPON). The both presented models include a novel approach for inter/intra –ONU (Optical Network Unit) scheduling mechanism as well as advanced support for multimedia and business-related services. Moreover, the single channel system could be upgraded to multichannel system on per-need basis i.e., only nodes with higher traffic demands could be upgraded. The aim of this approach is twofold. On the one side we hope to avoid the implementation of additional, complex algorithms usually related to QoS support in the access segment and on the other side to develop a solution in which new and old EPON technologies are able to coexist. This approach would eliminate the need for complex migrations, complicated and time consuming procedures as well as possible service outages in the access network. We present detailed simulation experiments with the aim of conducting a study of the performances of both presented approaches and validate both of them in the terms of the future application, further service development and implementation in the next generation broadband networks (NGNs).
Impact of elemental chemistry on water quality in Missouri reservoir
Authors: Onema Pauline , Ikem Abua , Knott C Katrina , Adojoh onema 
Published: November 2022

Abstract
Natural (weathering) and anthropogenic sources (e.g., sewage discharges, agricultural activities/fertilizers, mining, atmospheric deposition) contribute to the pollution of freshwater ecosystems (e.g., lakes, streams, etc.). The impact of pollution through trace elemental and sediment discharge in freshwater due to the bioaccumulation and biomagnification effects of methyl mercury (MeHg) has been reported in recent studies. Elevated Hg concentration in fish has been found in some lakes and new impoundment reservoirs. Thus, this study investigates the presence of Mercury (Hg), arsenic (As), cadmium (Cd), selenium (Se), lead (Pb), nickel (Ni), and zinc (Zn) to determine the composite of whole-body largemouth bass (LMB; Micropterus salmoides) samples across three Missouri Lakes (Port Hudson, Buffalo Bill, and Ben Branch reservoirs). Hg was measured by atomic absorption spectrometry while other elements were determined by inductively coupled plasma – optical emission spectrometry. Our results were compared with the US EPA Standard values to determine the concentration of 26 elements (Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Mo, Na, Ni, Se, V, Zn, B, Hg, Pb, P, Tl, Be, Ba, Sb, Ag, Al, and As). The results show a strong interrelationship of some water quality variables due to similarities in the chemical characteristics. In addition, the weekly intakes of trace elements compared with regulatory thresholds (US EPA) and the non-carcinogenic and carcinogenic risks via the consumption of muscle were observed.
A priori estimates for free boundary problem of 3D incompressible inviscid rotating Boussinesq equations
Authors: Hao Chengchun , Zhang Wei 
Published: November 2022

Abstract
In this paper, we consider the three-dimensional rotating Boussinesq equations (the “primitive” equations of geophysical fluid flows). Inspired by [25], we establish a priori estimates of Sobolev norms for free boundary problem of inviscid rotating Boussinesq equations under the Taylor-type sign condition on the initial free boundary. Using the same method, we can also obtain a priori estimates for the incompressible inviscid rotating MHD system with damping.
Epigenetic silencing of HTATIP2 in glioblastoma enhances nuclear translocation of the DNA-repair protein MPG affecting treatment resistance
Authors: Hegi Monika , Nguyen Thi Tham , Rajakannu Premnath , Pham Minh Diêu Thanh , Weman Leo , Jucht Alexander , Buri Michelle , Dommelen Kristof Van 
Published: November 2022

Abstract
DNA methylome analysis of glioblastoma (GBM) identified the HIV-1 Tat interactive protein 2 (HTATIP2) gene as aberrantly methylated and silenced. HTATIP2 is a negative regulator of importin β-mediated (KPNB1) cytoplasmic-nuclear translocation of proteins and its deregulation may alter the functionality of cancer relevant nuclear proteins. We propose N-Methylpurine-DNA Glycosylase (MPG), responsible for removing alkylated bases and initiating base excision repair (BER), as a potential GBM relevant candidate. Here we investigated the role of epigenetic silencing of HTATIP2 on the subcellular localization of MPG, and MPG-mediated DNA repair.
Induction of HTATIP2 expression in GBM cells lead to a significant shift of predominantly nuclear to cytoplasmic MPG, while depletion of endogenous levels of HTATIP2 resulted in enhanced nuclear MPG localization. We observed exclusion of MPG from the area exhibiting co-localization of HTATIP2 and KPNB1 in proximity to the nuclear membrane, suggesting competition of HTATIP2 with MPG to bind to KPNB1. In accordance, pharmacologic inhibition of KPNB1 similarly induced cytoplasmic retention of MPG as HTATIP2 expression. Reduced nuclear MPG localization, induced by HTATIP2 expression or depletion of MPG, yielded less P-H2AX-positive cells upon treatment with an alkylating agent. This suggested reduced MPG-mediated formation of apurinic/apyrimidinic (AP) sites, leaving behind unrepaired DNA lesions, hence, reflecting a reduced capacity of BER in response to the alkylating agent.
Taken together, these results suggest that epigenetic silencing of HTATIP2 may increase nuclear localization of MPG, thereby increasing the capacity of the tumor cells to repair treatment related lesions and eventually contributing to treatment resistance.
R0 Surgical Resection of Giant Dedifferentiated Retroperitoneal Liposarcomas in the COVID era: Nephrectomy or Not Nephrectomy?
Authors: Pegoraro Francesca , Domenico Santangelo , Alfonso Santangelo , Pelosio Luigi , Jamshidi Akbar , Camera Luigi , Imbriaco Massimo , Mainolfi Ciro Gabriele , Insabato Luigi , Accarino Rossella , Giuliano Mario , Carlomagno Nicola , D’Alessandro Vincenzo , Santangelo Michele 
Published: November 2022

Abstract
Background: Retroperitoneal sarcomas (RPS) are rare findings that can grow into large masses without eliciting severe symptoms. Nowadays surgical resection is the only radical therapy, whenever possible. We present two consecutive cases of RPSs that resulted in dedifferentiated liposarcomas (DDLPS) and underwent R0 surgical resection with and without a nephron-sparing procedure. The diagnostic workup, the surgical approach, the impact of late surgical management due to the COVID pandemic, and the latest literature on the topic will be discussed and analyzed.
Case Presentation: The patients, who refused to undergo any medical examination during the prior two years due to the COVID pandemic, were admitted to our Institution complaining about weight loss and general abdominal discomfort. In the first case, we observed a primitive giant abdominal right neoplasm of retroperitoneal origin enveloping and medializing the right kidney. The second patient had a similar primitive retroperitoneal giant left neoplasm which didn’t affect the kidney. Given the masses’ characteristics and the absence of distant metastases, after a multidisciplinary discussion, radical surgical removal was carried out for both patients. The lesions appeared well-defined from the surrounding tissues, and significantly compressed all the adjacent organs, without signs of infiltration. In the first patient, the right kidney was surrounded and undetachable from the tumor and it was removed en bloc with the mass. The second patient benefited from a nephron-sparing resection, thanks to the existence of a clear cleavage plane. The postoperative courses were uneventful. Both the histological examinations were oriented towards a DDLPS. And both patients were addressed with adjuvant chemotherapy.
Conclusions: The treatment of giant RPS is still challenging and requires multidisciplinary treatment as well as, when possible, radical surgical removal. The lack of tissue infiltration and the avoidance of major organs’ excision or reconstruction (including the kidney) could lead to an easier postoperative course and a better prognosis. When possible, surgical management of recurrences or incompletely resected masses must be pursued. As the COVID pandemic caused limited medicalization of many population groups and delayed diagnosis of other oncologic diseases, an increased number of DDLPSs could be expected in the near future.
Predators’ size influences life history traits of Aedes aegypti
Authors: Borges William Gabriel , Cozzer Gilberto Dinis , Durigon Giovana Rech , Lima-Rezende Cássia Alves , Rezende Renan Souza 
Published: November 2022

Abstract
Predator-prey relationships are not limited to predation. A predator may release chemical cues that may directly affect the physiology and behavior of a prey by fear and intimidation. Our objective was testing the effect of the body size of predator (dragonfly larvae) on the larval development time and mortality, as also, on the survival, wing asymmetry and adult size of Ae. aegypti. Using a microcosm set-up, we simulated the predation risk by dragonflies (Odonata, Libelulidae family) over Aedes aegypti. Microcosms consisted of 40 larvae of Ae. aegypti under the indirect effect of predators with different body sizes (four treatments comprising different body size classes; n = 5 per treatment). We found that intermediate-sized predators had the highest effects on the mosquito's life history traits. Predator presence increased prey larval mortality (±150%) and accelerated development times (±33%), and reduced adult body size (± 24%) and survival (56%). On the other hand, no change in asymmetries of wings size was observed in Ae. aegypti mosquitoes. Therefore, our results support that both predator presence and size are responsible for changes in Ae. aegyptitraits during the larval and adult stages.
The effect of type 2 diabetes mellitus on the prognosis of osteoporotic vertebral compression fracture with OF classification after vertebroplasty
Authors: Wang Zixiang , Wang Hanquan , Zhuang Chenyang , Chen Weisin , Hoang Tien-Manh , Li Juan , Lin Hong 
Published: November 2022

Abstract
Background: To analyze the clinical and radiological effects of type 2 diabetes mellitus (T2DM) on the prognosis of osteoporotic vertebral compression fracture (OVCF) after percutaneous vertebroplasty (PVP), and explore the prognostic value of OF classification.
Methods: OVCF patients who received PVP from January 1, 2016 to June 30, 2021 were divided into T2DM group and control group. Visual analogue scale (VAS), Oswestry Disability Index (ODI), bone cement leakage, new OVCF, anterior, middle, and posterior portion heights (APH, MPH and PPH) of vertebral body and local cobb angle (LCA) on X-ray before surgery, 2 days after surgery, 6 months, and 12 months after surgery were recorded and the OF classification was performed.
Results: A total of 261 vertebral bodies were included, containing 68 in the T2DM group and 193 in the control group. There were no differences in baseline characteristics between the two groups. At 6 months after PVP, the LCA of the T2DM group was 8.29±4.90° greater than that of the control group 6.05±5.18° (P=0.002). At 12 months, the APH recovered 8.13±12.90%, which was less than 12.51±14.92% of the control group (P=0.032), and 19.07±16.47% of the MPH recovery was less than the control group’s 24.63±17.67% (P=0.024). Compared with the control group, OF 2 vertebral bodies of the T2DM group at 12 months postoperatively in MPH (14.82±14.71% vs 24.78±18.16%, P=0.023) and LCA (5.65±4.06° vs 3.26±4.86°, P=0.043) restored significantly worse. Besides, OF 3 restored worse in APH, MPH and LCA at 12 months postoperatively (APH: 5.40±11.02% VS 13.57±12.79%, P=0.008; MPH: 11.22±15.53% VS 17.84±12.36%, P=0.041; LCA: 10.85±3.79°VS 7.97±3.83°, P=0.002). There was no difference in radiological outcomes of OF 4 between the two groups.
Conclusions: The degree of fractured vertebral compression, the recovery of the height and angle obtained immediately after surgery and the clinical symptoms in T2DM patients were not different from those in the control. However, vertebral body morphology of T2DM patients was worse since the sixth month after surgery. OF classification has a good prognostic reference value for both the control and the T2DM population.
A significant difference in the brainwave activity of mediums during mediumship and imagination
Authors: Davies Elizabeth , Pettitt Nick 
Published: November 2022

Abstract
Context

A medium, in the context of these experiments, is a person who receives and transmits information from a hypothesised dead person or spiritual being. During the early stages of mediumship development, mediums often experience difficulty in trusting their true perceptions, believing these to be their imagination. It is important to determine if there is any signatory difference in the brain between the two active states of mediumship and imagination.

Objective

These experiments test the hypothesis that there is a measurable difference in the brainwave activity of mediumship and imagination.

Participants

The two medium participants were male and female. They were also the experimenters. The female,(F). aged 73, participated as medium in 33 separate sessions. The male,(M), aged 60, participated as medium in 13 separate sessions. The participants were unrelated and lived in different neighbourhoods, but had been practising mediumship development together for five years. The sessions took place in their normal practice environment.

Methods

There were 3 sets of experiments, each set involving a different form of mediumship. In each experiment there was electroencephalographic continuous recording, with simultaneous audio recording of the medium, during 30 minutes’ mediumship activity, either followed by, or preceded by, 30 minutes’ imagination/fabrication activity. The data collected was monitored for frequency spectral characteristics and analysed for each cerebral hemisphere. The audio recordings were transcribed and analysed for word count.

Results

Each of the three experiments showed a significant decrease in the ratio of mean delta to gamma waveband amplitudes, for both cerebral hemispheres, in mediumship when compared with imagination.

Conclusion

Both mediums showed a consistent significant difference in the delta/gamma ratio in mediumship from that shown in imagination. This supports the hypothesis that there is a difference in the brainwave activity in mediumship as demonstrated in these experiments, from that shown in imagination.
How working from home affected the social networks and satisfaction of migrant populations during COVID-19
Authors: Wanner Philippe , Ruedin Didier , Rodriguez Roberto Desponds 
Published: November 2022

Abstract

Objective
We examine how the requirement to work from home during COVID-19 affected the social integration of immigrants.
Methods
Using a representative panel of 7,400 immigrants to Switzerland, we run ordered logistic regression models to test how a change in job status and the obligation to work from home is reflected in a range of social integration and well-being indicators.
Results
Switching to working from home during the semi-lockdown period is associated with increased difficulties in communicating with the local population, adapting to the Swiss way of life, and making friends. It is also associated with increased dissatisfaction with social relationships but does not lead to a more negative evaluation of the stay in Switzerland.
Conclusion
We conclude that work is a place of socialization for migrant populations, and therefore, it is important to consider the negative impact of a forced shift to telework on the integration of these populations.
Assessment of parent’s awareness about sight-threating Eye diseases in children in Damascus Hospital
Authors: Al-Mamar Khaled , Othman Noureddine , Salman Afraa , Al-Manasfi Anas 
Published: November 2022

Abstract
Background:
Eye diseases are among the common health problems that a person may be exposed to and are of particular importance in childhood. These diseases range from simple health problems that go away without the need for medical treatment, and health problems that require medical intervention to treat them. Care must be taken to periodically review the ophthalmologist. To conduct the necessary examinations, avoid the development of eye diseases as much as possible, and reduce the chance of complications that may accompany it, including loss of vision, and common diseases that may affect the eye, we mention the following: congenital glaucoma, refraction, strabismus, congenital cataract, amblyopia (lazy eye Retinopathy of preterm infants.
Design:
A cross-sectional study was conducted using the questionnaire tool, targeting the parents who attended Damascus Hospital, the eye clinics within the hospital, and the Al-Mujtahid department, the first aid and care department.
Methods:
The questionnaires used were randomly distributed to 518 participants to form the total sample studied.
Results:
In our study, we focused on the demographic aspects related to the sample members at the beginning, which will form the first and main party in the various relationships and associations studied in the context of our research, as they carry an important value and constitute a basic indicator that reflects the groups that have the greatest or least amount of knowledge about eye diseases that threaten sight in children, Among the 518 participants, females were more than half of the sample with a percentage of 59.7%, while males were 40.3%, and most of them were in the age group of 30–40 years with a percentage of 44.4%, and most of them were married at a rate of 84.7%, and the educational level was somewhat similar, between intermediate and secondary education As for the nature of the participants’ work, housewives had the largest percentage, reaching 37.3%, and 72% of the participants had one to three children.
Anti-persistent adherence dynamic of the COVID-19 vaccines
Authors: Fernandes Leonardo H S , Silva Maria A R , de Araujo Fernando Henrique Antunes 
Published: November 2022

Abstract
This research explores the multifractal dynamics of time series of the daily number of vaccinees for COVID-19, considering six European countries (Belgium, Denmark, France, Germany, Greece and Italy) using the Multifractal Detrended Fluctuations Analysis (MFDFA). We calculate the multifractal spectrum 𝑓(𝛼) and apply a fourth-degree polynomial regression fit to estimate the complexity parameters that describe the degree of multifractality of the underlying process. We found that the multifractal dynamics of all these countries are characterized by strongly anti-persistent behavior or long-term anti-persistent correlations (𝛼0 < 0.5) a lower degree of multifractality, and small fluctuations are dominant in the multifractal spectrum. From an immunization perspective, it means that a panorama that encompasses the population’s behaviour is marked by the dynamics of anti-persistent adherence to COVID-19 vaccines. Our findings confirm that the period of immunization of the population that adhered to the vaccination campaigns is short and that the application of new doses of vaccines must obey this phenomenology to keep people safe. In addition, we used the multifractal efficiency coefficient to rank countries that are most proactive in developing campaigns that promote greater adherence and loyalty to COVID-19 vaccines. Our findings indicate that Germany, Belgium and France were more efficient than Greece, Denmark and Italy
Analysis of long-term rainfall trends in Bangladesh
Authors: Rahman Md. Mizanur , Abd Sk. Md. Abubakar 
Published: November 2022

Abstract
The study of rainfall trends is critically important for Bangladesh whose food security and
economy are dependent on the timely availability of water. Trends in monthly, seasonal, and annual rainfall on the 08 (eight) divisions as well as all Bangladesh were examined in this study using a monthly data series of 40 years (1981–2020). Most of the divisions showed decreasing trend in monsoon seasonal rainfall but for only three divisions namely Dhaka, Rajshahi and Rangpur were statistically significant out of eight divisions except in Chattogram division, whereas rainfall trend showed positive but not statistically significant. On an annual scale, all divisions also showed a decreasing trend with insignificant exceptions in Dhaka and Rajshahi divisions, which showed a statistically significant trend. For all Bangladesh, no significant trend was detected for seasonal rainfall. Annual, pre-monsoon, monsoon and winter rainfall showed decreasing trend, while post-monsoon rainfall showed increasing trend at the national scale but was not significant. Only annual rainfall was detected as a statistically significant decreasing trend for all Bangladesh.