bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptions towards integrated care through the narrative of practicing social workers and psychologists in PHC: a cross-case analysis
Authors: Ryapolova Nadezhda , Galea Jerome T. , Greene Karah Y. 
Published: December 2022

PurposeIn a collective effort to build a patient-centered and coordinated health care system, social workers and psychologists are being progressively introduced to primary health care (PHC) settings worldwide. The present study aims to explore the current status of integration through the narrative of social workers and psychologists in PHC settings in Kazakhstan.Design/methodology/approachIn this paper purposive snowball sampling was utilized to recruit social workers and psychologists who work, or used to work, in PHC settings since the onset of integration in Nur-Sultan for participation in an in-depth interview. A semistructured interview guide was based on normalization process theory (NPT). Interviews were conducted via video conference, in Russian language, lasted no more than 50 min, and transcribed verbatim. Cross-case analysis of eight cases was performed using NPT constructs.FindingsCross-case analysis included findings from the interviews from five social workers and three psychologists. Four major constructs of implementation process from NPT were reflected in the findings: coherence (believes integration improves patient care, functions within integrated care), cognitive participation (individual changes to role performance, mechanisms of work), collective action (status of support from stakeholders, cooperation within a multidisciplinary team) and reflective monitoring (existing mechanisms for monitoring the integration).Research limitations/implicationsDespite organizational integration, there is a lack of successful clinical integration of social workers and psychologists in PHC settings of Kazakhstan, which is manifested by a lack of understanding of responsibilities and functions of these mental health care specialists. Consensus was reached by all participants that both social workers and psychologists are valuable assets in a multidisciplinary team.Originality/valueThe present study contributes to the current knowledge of integrated PHC service delivery by addressing the status of integrated care in Kazakhstan from interviews with key stakeholders in social work and mental health. Moving forward, improvements are needed to (1) establish the monitoring mechanism to evaluate the status of integration, (2) enhance effective collaboration within multidisciplinary teams in PHC settings and (3) increase awareness among medical workers and community members on mental health issues and the available support offered by social workers and psychologists to promote quality of life in a holistic, integrated manner.
The impact of governance on economic growth: spatial econometric approach
Authors: Mahran Hisham Abdeltawab 
Published: December 2022

PurposeThis paper investigates the impact of governance on economic growth, considering the spatial dependence between countries.Design/methodology/approachThe study employs spatial regression models to estimate the impact of governance on economic growth in a sample of 116 countries worldwide in 2017.FindingsThe findings imply that the influence of governance on economic growth is statistically significant. Moreover, if all other economic control variables are constant, 1% increase in governance raises the economic growth on average by 1% at 10%, 5% and 1% significance levels, respectively. Furthermore, each country's rise in economic growth favorably and substantially influences the economic growth of its bordering nations. The unobserved characteristics or similar unobserved environments in adjacent countries also affect its economic growth.Originality/valueThis study adds to the discussion and investigation of the influence of governance on economic growth by considering the spatial dependence between countries, which is lacking in the literature.
A logical error in Gassmann poroelasticity
Authors: Thomsen Leon 
Published: December 2022

AbstractThe well‐known ‘Biot–Gassmann’ formula for the undrained compressibility of porous rock is in error. The error was introduced by Gassmann (implicitly revising earlier work by Biot) and results in an expression which is simpler than Biot's corresponding expression, containing only one material parameter (KS) in place of Biot's two (H and R). The error occurred when Gassmann applied a hydraulically open theorem to a hydraulically closed system, thus violating the assumptions of the undrained compressibility. Similar errors have marred the many subsequent derivations of Gassmann's result. Biot's (prior) correct formulation was subsequently rederived exactly (in different notation) by Brown and Korringa, and separately by Rice and Cleary. The inconsistency between Gassmann and these three analyses is caused by Gassmann's logical error, rather than by the issue of solid micro‐homogeneity. The additional parameter may be experimentally determined via the ‘Skempton B‐coefficient’ (the ratio of fluid pressure to external pressure in an undrained quasi‐static compression test). This correction resolves a long‐established inconsistency between Gassmann's result and effective‐medium theory. A new generation of experimentation is required to determine the systematics of the magnitude of the correction to the Gassmann result.
Temporal analysis of GBIF data reveals the restructuring of communities following climate change
Authors: Lajeunesse Armelle , Fourcade Yoan 
Published: December 2022

Abstract

Multiple studies revealed an effect of climate change on biodiversity by investigating long‐term changes in species distributions and community composition. However, many taxa do not benefit from systematic long‐term monitoring programmes, leaving gaps in our current knowledge of climate‐induced community turnover.

We used data extracted from the Global Biodiversity Information Facility to characterize community reorganization under climate change for nine animal taxonomic groups (ants, bats, bees, birds, butterflies, earthworms, frogs, rodents and salamanders), which, for most of them, had never been studied before in this regard. Using a presence‐only community temperature index (CTI), reflecting the relative proportion of warm‐ and cold‐adapted species, we tested whether and how species' assemblages were affected by climate change over the last 30 years.

Across Europe and North America, we observed an average increase in CTI, consistent with a gradual species turnover driven by climate change.

At the local scale, we could observe that the composition of most species assemblages changed according to temperature variations. However, this change in composition always occurred with a lag compared to climate change, suggesting that communities are experiencing a climatic debt. Results suggest that anthropization may play a role in the decoupling between the change in CTI and the change in local temperature.

The results of our study highlight an overall thermophilization of assemblages as a response of temperature warming. We demonstrated that this response may exist for a large range of understudied terrestrial animals, and we introduced a framework that can be used in a broader context, opening new opportunities for global change research.
Abundance and biomass of Bdelloid rotifers in the microbial mats from East Antarctica: The ecological relations between microscopic phototrophs and invertebrates
Authors: Wada Tomotake , Kudoh Sakae , Koyama Hiroshi , Iakovenko Nataliia , Elster Josef , Kvíderová Jana , Otani Masahiro , Shimada Sho , Imura Satoshi 
Published: December 2022

AbstractMicrobial mats in Antarctica are known to harbor microscopic organisms. Recently, comprehensive studies of the diversity of microbial mats have been conducted using genetic analysis of 16 S rRNA and 18 S rRNA genes. However, the quantitative biological contribution of each microorganism constituting the microbial mats remains unknown. We surveyed microscopic phototrophs and invertebrates in mats sampled from five lakes and one ephemeral wetland on the Sôya Coast, East Antarctica. We identified seven taxonomic groups of phototrophs, of which five (Orders Chroococcales, Nostocales, and Oscillatoriales, and Classes Chlorophyceae and Bacillariophyceae) were found at all sites, and three taxonomic groups of invertebrates (Class Bdelloidea, and Phyla Nematoda, Tardigrada). Bdelloidea were the most predominant invertebrate group at all sampling sites. The biomass of the Bdelloidea was 4–10 times higher than the total biomass of the Nematoda and Tardigrada at all sampling sites. The total biomass of all groups identified was higher in the ephemeral wetland than in the lakes. Of the five lakes, Skallen Ôike had the highest total biomass. These findings suggest that higher biomasses exist in eutrophic environments (the marine relict lake, Skallen Ôike, and an ephemeral wetland) where nutritional carryover or higher nutritional flux is expected. In addition, statistical differences in the community structure among the lakes and the ephemeral wetland could be detected based on the biomass compositions of the taxonomic groups. The community structure of each lake and the wetland was statistically dissimilar, indicating the phototrophs and invertebrates had a unique community structure at each study site.
Current developmental screening practices in young children with sickle cell disease
Authors: Aguwa Chibuzo J. , Cannon Alicia D. , Casella James F. , Shapiro Bruce K. , Lance Eboni I. 
Published: December 2022

SummaryDespite recent developmental screening guidelines, rates of neurodevelopmental disorders (NDDs) remain lower than expected in children with sickle cell disease (SCD). A retrospective chart review identified 276 eligible patients; 214 charts were available for developmental screening and 207 charts for autism‐specific screening. Developmental surveillance/screening was conducted in 70% of charts and autism‐specific screening in 19% of charts. Validated tools were used in 32% of developmental screenings and 92% of autism‐specific screenings. Many children (57%) were screened outside recommended ages. In conclusion, children with SCD are not regularly receiving appropriate developmental screening and surveillance by their healthcare providers.
Latitudinal cline of flowering and fruiting phenology in Fagaceae in Asia
Authors: Araye Quenta , Yahara Tetsukazu , Satake Akiko 
Published: December 2022

AbstractThe seasonal timing of flowering and fruiting is crucial for the reproductive success of plants and for resource availability to animals. Although plants synchronize their reproductive timing to coincide with appropriate seasons by responding to environmental cues, seasonal variations in temperature and precipitation vary minimally in very wet tropical environments. To explore the latitudinal cline in the reproductive phenology of the Fagaceae in Asia, we analyzed phenology data for a total of 94, 121, and 219 species from Thailand, Malesia, and China, respectively, in the three genera of Fagaceae, Quercus, Castanopsis, and Lithocarpus. We found that Quercus and Castanopsis showed flowering peaks in April in China. In Thailand, the peak shifted to an earlier month, and the peak disappeared in Malesia. The flowering period lengthened with decreasing latitude in the animal‐pollinated genera Castanopsis and Lithocarpus. However, this was not the case for the wind‐pollinated genus Quercus. The fruiting period lengthened with decreasing latitude in all three genera. We examined the relationship between reproductive phenology and climatic factors. The combination of monthly temperature and precipitation best explained the monthly change in the proportion of flowering and fruiting species in China in all three genera. However, climatic factors had almost no impact on the predictive ability of the model in Malesia. Our results on phenological shifts in the family Fagaceae, from the temperate climates and seasonal tropics to the humid tropics, provide valuable information for predicting phenological changes in future climate change.
Survival and long‐term socioeconomic consequences of childhood and adolescent onset of brain tumours
Authors: Pickering Line , Main Katharina M. , Feldt‐Rasmussen Ulla , Sehested Astrid , Mathiasen René , Klose Marianne , Ibsen Rikke , Kjellberg Jakob , Jennum Poul 
Published: December 2022

AbstractAimTo evaluate survival distributions, long‐term socioeconomic consequences, and health care costs in patients with childhood and adolescent onset of brain tumours in a Danish nationwide prospective cohort study.MethodA search of national registries identified 2283 patients (1198 males, 1085 females; mean age 9 years 6 months [SD 5 years 7 months]) diagnosed with a brain tumour between 1980 and 2015 and aged no older than 18 years at diagnosis. These were compared with sex‐, age‐, and residency‐matched comparison individuals. Patients with malignant tumours were compared with those with benign tumours. Survival distributions were estimated by the Kaplan–Meier method and hazard ratio by the Cox proportional hazard model. Socioeconomic data at age 20 and 30 years were assessed.ResultsThe probability of mortality was highest during the first year after tumour diagnosis. In young adulthood, the patients were generally less likely to be married, had lower grade‐point averages, educational levels, and income, were less likely to be in employment, and had higher health care costs than comparison individuals. Patients with malignant tumours had worse outcomes with respect to education, employment, and health care costs than those with benign tumours.InterpretationA diagnosis of brain tumour in childhood and adolescence adversely affects survival and has negative long‐term socioeconomic consequences, especially in patients with malignant tumours. These patients require continuous social support.
The gut microbiome dysbiosis is recovered by restoring a normal diet in hypercholesterolemic pigs
Authors: Schoch Leonie , Sutelman Pablo , Suades Rosa , Badimon Lina , Moreno‐Indias Isabel , Vilahur Gemma 
Published: December 2022

AbstractBackgroundGut microbiota is thought to modulate cardiovascular risk. However, the effect of cardiovascular primary prevention strategies on gut microbiota remains largely unknown. This study investigates the impact of diet and rosuvastatin interventions on gut microbiota composition in hypercholesterolemic pigs and associated potential changes in host metabolic pathways.MethodsDiet‐induced hypercholesterolemic pigs (n = 32) were randomly distributed to receive one of the following 30‐day interventions: (I) continued hypercholesterolemic diet (HCD; n = 9), (II) normocholesterolemic diet (NCD; n = 8), (III) continued HCD plus 40 mg rosuvastatin/daily (n = 7), or (IV) NCD plus 40 mg rosuvastatin/daily (n = 8). Faeces were collected at study endpoint for characterisation of the gut microbiome and metabolic profile prediction (PICRUSt2). TMAO levels and biochemical parameters were determined.ResultsPrincipal coordinate analyses (beta‐diversity) showed clear differences in the microbiota of NCD vs HCD pigs (PERMANOVA, p = .001). NCD‐fed animals displayed significantly higher alpha‐diversity, which inversely correlated with total cholesterol and LDL‐cholesterol levels (p < .0003). NCD and HCD animals differed in the abundance of 12 genera (ANCOM; p = .001 vs HCD), and PICRUSt2 analysis revealed detrimental changes in HCD‐related microbiota metabolic capacities. These latter findings were associated with a significant fivefold increase in TMAO levels in HCD‐fed pigs (p < .0001 vs NCD). The addition of a 30‐day rosuvastatin treatment to either of the diets exerted no effects in microbiota nor lipid profile.ConclusionIn hypercholesterolemic animals, the ingestion of a low‐fat diet for 30 days modifies gut microbiota composition in favour of alpha‐diversity and towards a healthy metabolic profile, whereas rosuvastatin treatment for this period exerts no effects.
LncRNA BBOX1‐AS1 targets miR‐361‐3p/COL1A1 axis to drive the progression of oesophageal carcinoma
Authors: Ma Ruidong , Lu Yuhai , He Xiaoping , Zeng Xiaofei 
Published: December 2022

AbstractBackgroundOesophageal carcinoma (EC) is one of the types of prevalent malignant cancer in the globe. Many researchers reported the vital role played by long‐coding RNAs in EC. In the current research, we investigated the mechanisms of the action of lncRNA BBOX1‐AS1 in EC progression.MethodsIn EC tissues and EC cells, the expression levels of miR‐361‐3p along with COL1A1 and BBOX1‐AS1 were detected through RT‐qPCR or western blotting. MiR‐361‐3p interactions with BBOX1‐AS1 or COL1A1 were verified through Luciferase reporter and RIP tests. Loss of function combined with caspase‐3 activity, CCK‐8 and Transwell assays was performed to investigate cell apoptosis, proliferation and migration, respectively. Knockdown of BBOX1‐AS1 was used for evaluating BBOX1‐AS1 effects on tumour development in vivo.ResultsBBOX1‐AS1 was remarkably elevated in EC tissues and cells. In addition, the silencing of BBOX1‐AS1 attenuated the cell viability, cell migration and enhanced cell apoptosis of EC, as well as suppressed EC tumour formation in vivo. Moreover, BBOX1‐AS1 was found to be a sponge of miR‐361‐3p, which downregulated miR‐361‐3p expression. MiR‐361‐3p inhibitor rescued the anti‐tumour effect of BBOX1‐AS1 knockdown on the progression of EC. Furthermore, we discovered that miR‐361‐3p specially bound to COL1A1 3′UTR and downregulated COL1A1 and COL1A1 reduction declined the promoting effect of silencing miR‐361‐3p on EC cell malignant phenotypes.ConclusionBBOX1‐AS1 facilitated the EC development and malignancy via miR‐361‐3p/COL1A1 axis, indicating BBOX1‐AS1 could be a novel therapy target for the diagnostic of EC.
Effective T‐cell replete haploidentical stem cell transplantation for pediatric patients with high‐risk hematologic disorders
Authors: Tannumsaeung Supavich , Anurathapan Usanarat , Pakakasama Samart , Pongpitcha Pongpak , Songdej Duantida , Sirachainan Nongnuch , Andersson Borje S. , Hongeng Suradej 
Published: December 2022

AbstractObjectivesPatients with high‐risk hematologic diseases require intensive modalities, including high‐dose chemotherapy and allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Haploidentical T‐cell–replete transplantation is a logical choice because of the limited availability of matched sibling donors and the prolonged time needed to identify matched unrelated donors in Thailand.MethodsThe clinical outcomes data of 43 patients undergoing allo‐HSCT were reviewed. All patients had high‐risk hematologic malignancies, were younger than 20 years, and were in complete cytological remission at the time of allo‐HSCT. We used two different conditioning regimens: total body irradiation (TBI) combined with cyclophosphamide, fludarabine, and melphalan (n = 23) and thiotepa combined with fludarabine and busulfan (n = 20). All patients received a graft‐versus‐host disease prophylaxis regimen consisting of cyclophosphamide, mycophenolate mofetil, and a calcineurin inhibitor or sirolimus.ResultsThere was no difference in engraftment between patients receiving either of the regimens. After a median follow‐up of 35.8 (range, 0.6–106.2) months, the overall survival (OS) and event‐free survival (EFS) rates were 62.4% and 54.7%, respectively. OS and EFS were comparable between the respective regimens.ConclusionsWe conclude that thiotepa‐based conditioning has similar efficacy and tolerability as TBI‐based conditioning for haploidentical HSCT with post‐transplant cyclophosphamide.
The gut microbiota is important for the maintenance of blood–cerebrospinal fluid barrier integrity
Authors: Knox Emily G. , Lynch Caoimhe M. K. , Lee Ye Seul , O'Driscoll Caitriona M. , Clarke Gerard , Cryan John F. , Aburto Maria R. 
Published: December 2022

AbstractThe gut microbiota communicates with the brain through several pathways including the vagus nerve, immune system, microbial metabolites and through the endocrine system. Pathways along the humoral/immune gut microbiota–brain axis are composed of a series of vascular and epithelial barriers including the intestinal epithelial barrier, gut–vascular barrier, blood–brain barrier and blood–cerebrospinal fluid barrier. Of these barriers, the relationship between the gut microbiota and blood–cerebrospinal fluid barrier is yet to be fully defined. Here, using a germ‐free mouse model, we aimed to assess the relationship between the gut microbiota and the integrity of the blood–cerebrospinal fluid barrier, which is localized to the choroid plexus epithelium. Using confocal microscopy, we visualized the tight junction protein zonula occludens‐1, an integral aspect of choroid plexus integrity, as well as the choroid plexus fenestrated capillaries. Quantification of tight junction proteins via network analysis led to the observation that there was a decrease in the zonula occludens‐1 network organization in germ‐free mice; however, we did not observe any differences in capillary structure. Taken together, these data indicate that the blood–cerebrospinal fluid barrier is another barrier along the gut microbiota–brain axis. Future studies are required to elucidate its relative contribution in signalling from microbiota to the brain.
Complications of equine cheek teeth extractions
Authors: Dixon Padraic M. 
Published: December 2022

SummaryDue to the length of the reserve crown and roots of equine cheek teeth, especially in young horses, their extraction (exodontia) can be a challenging procedure with the potential for many types of post‐extraction complications to develop. The prevalence of post‐extraction complications is greatly influenced by the exodontia technique used, with unacceptably high levels of complications with the traditional repulsion technique and conversely, low levels of complications with oral extraction performed by skilled operators. Recent objective studies on post‐exodontia problems in horses have also highlighted some risk factors for the development of post‐extraction problems including exodontia of rostral mandibular teeth in young horses, and exodontia of teeth with apical infections. The recent recognition that some nonhealing post‐extraction equine alveoli suffer from a disorder very similar to dry socket in humans, may help clinicians to recognise, treat and possibly help prevent this disorder.