bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are smart contracts too smart for Supply Chain 4.0? A blockchain framework to mitigate challenges
Authors: Grida Mohamed , Mostafa Noha A. 
Published: January 2022

PurposeSmart contracts are self-executing computer programmes that have the potential to be used in several applications instead of traditional written contracts. With the recent rise of smart systems (e.g. Internet of things) and digital platforms (e.g. blockchain), smart contracts are gaining high interest in both business and academia. In this work, a framework for smart contracts was proposed with using reputation as the system currency, and conducts currency mining through fulfilling the physical commitments that are agreed upon.Design/methodology/approachA game theory model is developed to represent the proposed system, and then a system dynamics simulator is used to check the response of the blockchain with different sizes.FindingsThe numerical results showed that the proposed system could identify the takeover attacks and protect the blockchain from being controlled by an outsider. Another important finding is that careful setting of the maximum currency amount can improve the scalability of the blockchain and prevent the currency inflation.Research limitations/implicationsThis work is proposed as a conceptual framework for supply chain 4.0. Future work will be dedicated to implement and experiment the proposed framework for other characteristics that may be encountered in the context of supply chain 4.0, such as different suppliers' tiers, different customer typologies and smart logistics applications, which may reveal other challenges and provide additional interesting insights.Practical implicationsBy using the proposed framework, smart contracts and blockchains can be implemented to handle many issues in the context of operations and supply chain 4.0, especially in times of turbulence such as the COVID-19 global pandemic crisis.Originality/valueThis work emphasizes that smart contracts are not too smart to be applied in the context of supply chain 4.0. The proposed framework of smart contracts is expected to serve supply chain 4.0 by automating the knowledge work and enabling scenario planning through the game theory model. It will also improve online transparency and order processing in real-time through secured multitier connectivity. This can be applied in global supply chain functions backed with digitization, notably during the time of the pandemic, in which e-commerce and online shopping have changed the rules of the game.
Interplay of coordination, co-creation and community building: examining interprofessional collaboration in workplace development efforts in health care
Authors: Seppänen Laura , Koskela Inka , Heikkilä Heli , Leino-Kilpi Helena , Rautava Päivi , Stolt Minna , Siekkinen Mervi , Valtanen Elisa , Sulosaari Virpi 
Published: January 2022

Purpose
Interprofessional collaboration (IPC) is increasingly important in work and workplace learning. The purpose of this paper is to investigate the characteristics of IPC that are relevant for learning and developing at work.

Design/methodology/approach
We examine IPC in the discussion data of health care professionals when designing, implementing and evaluating developmental tasks. Qualitative content analysis is carried out on temporally sequential task trajectories, considering IPC from the perspective of the objects and goals of IPC task activity in developmental efforts.

Findings
The developmentally relevant characteristics of IPC are crystallized in the concepts of coordination, co-creation and community building, which play different, interdependent roles in development efforts. We show their interplay and how they complement each other in practice.

Research limitations/implications
Our findings regarding IPC characteristics are to be interpreted as working hypotheses and resources for further research.

Practical implications
Understanding the dynamics of IPC is useful for renewing work practices. Attention to the interplay and complementarity of IPC characteristics may help in the design and implementation of effective and sustained development efforts.

Originality/value
The dynamics of IPC in developmental settings have not been sufficiently studied. This paper proposes three developmentally relevant and intertwined characteristics of IPC for scholars of workplace learning.
Resolving stress of university teacher: exploring role of workplace spirituality and constructive workplace deviance
Authors: Garg Naval , Kumari Sarika , Punia B.K. 
Published: January 2022

PurposeThe study explores the relationship between workplace spirituality and work stress among university teachers. It also investigates the mediating effect of constructive deviance amid the association between workplace spirituality and stress among Indian university teachers.Design/methodology/approachThe association between spirituality and stress is studied using correlation and multiple regression. The mediating effect of constructive deviance is examined using the Sobel test and bootstrapping estimates using Hayes' PROCESS macro. The hierarchical regression is used to report direct and indirect effects.FindingsFindings reveal a significant negative association between the six dimensions of workplace spirituality and stress. The results also concluded the mediation effect of constructive deviance, which means workplace spirituality promotes constructive deviance that influences educators' stress levels.Originality/valueThe study is based on primary data collected by the author. It is one of the first explorations of the mediating effect of constructive deviance in the relationship of six dimensions of workplace spirituality and work stress among teachers.
Did the Dodd–Frank Whistleblower Provision Deter Accounting Fraud?
Authors: BERGER PHILIP G. , LEE HEEMIN 
Published: January 2022

ABSTRACTWe examine the deterrence effect of the Dodd–Frank whistleblower provision on accounting fraud. To facilitate causal inference, we use state False Claims Acts (FCAs), under which whistleblowing about accounting fraud at a firm invested in by a state's pension fund can result in monetary rewards from that state's government. We divide our sample into firms exposed and not exposed to whistleblowing risk from a state FCA during the 2008–2010 period that preceded the 2011 SEC implementation of the Dodd–Frank whistleblowing provision. We hypothesize that firms already exposed to a state FCA whistleblower law are less affected by the Dodd–Frank whistleblower provision. Using the companies exposed to a state FCA as control firms in our Dodd–Frank tests, the remaining firms constitute the treatment sample. We find that exposure to Dodd–Frank reduces the likelihood of accounting fraud of treatment firms by 12%–22% relative to control firms, but do not find that it affects audit fees.
Morphology of the mammary gland in romanian buffalo
Authors: Tătaru Mariana , Stan Florin , Martonoș Cristian Olimpiu , Gal Adrian , Mârza Sorin Marian , Purdoiu Robert Cristian , Lăcătuș Radu , Damian Aurel , Șonea Cosmin , Mireșan Vioara , Papuc Ionel 
Published: January 2022

AbstractThe gross morphology of the mammary gland in buffalo is the foundation that is necessary for the process to improve the species for agricultural use. This study determined the mammary gland's anatomical, histological and imaging structure in the Romanian buffalo. The research material was represented by ten udders, five udders from adult buffaloes and five udders from young females slaughtered in the abattoir. The udders were collected immediately after slaughtering the animals, then transported to USAMV Cluj‐Napoca, Romania, examined macroscopically, histologically and through imagistic methods. The morphological examination tracked the topography, external conformation, vascularization and innervation of the mammary gland in the buffalo. The histological examination highlighted differences between the ductoacinary structures of the mammary gland parenchyma in adult buffaloes compared with young females. The imaging examination showed the detachment of the middle mammary artery and the arterial anastomoses established between the mammary arteries on the left side of the udder and those on the right side and between the arteries of the quarters on the same side. This research can be theoretical and practical support to other studies in establishing the most accurate diagnosis and therapeutic protocol in various clinical pathologies of the udder in buffalo.
Does deep neuromuscular blockade provide improved outcomes in low pressure laparoscopic colorectal surgery? A single blinded randomized pilot study
Authors: Lowen Darren John , Hodgson Russell , Tacey Mark , Barclay Karen L. 
Published: January 2022

AbstractBackgroundLow intra‐abdominal pressure during laparoscopic colorectal surgery may improve outcomes and reduce hospital stay, in addition to Enhanced Recovery After Surgery (ERAS) protocols. There is concern that low pressure reduces laparoscopic vision and may increase surgical complications. Deep neuromuscular blockade may abrogate any reduction in vision of low‐pressure pneumoperitoneum. However, antagonism of deep neuromuscular blockade at completion of surgery necessitates the use of sugammadex, which is prohibitively expensive, if there are no surgical benefits and warrants further study.MethodsA single institution, single blinded randomized controlled pilot study was performed comparing deep to moderate neuromuscular blockade in major laparoscopic colorectal surgery.ResultsThirty‐eight patients were randomized to deep or moderate neuromuscular blockade. There were no statistically significant differences between groups, when comparing key patient demographics, or surgeon satisfaction with view, which required increased pressure or further relaxation demands. The deep blockade group had increased QoR15 scores and a decrease in pain, C‐Reactive Protein (CRP) measurements and operating times, although were non‐significant. The moderate group had slightly higher incidents of Medical Emergency Team (MET) calls and more severe complications, although were non‐significant.ConclusionsLow intra‐abdominal pressure in laparoscopic colorectal surgery is feasible and allows adequate surgical visualization, regardless of the degree of neuromuscular blockade. Potential benefits of deep neuromuscular blockade may include improved pain and quality of recovery and a possible reduction of complications; however a larger cohort is required to confirm this. Future ERAS protocols may consider deep neuromuscular blockade with low intra‐abdominal pressure to further benefit patients.
Designer organs: The future of personalized transplantation
Authors: Buchwald Julianna E. , Martins Paulo N. 
Published: January 2022

AbstractOrgan transplantation is the definitive treatment for end‐stage solid organ diseases, yet biological and logistical barriers reduce the rate of successful organ transplants. As such, there is a need for gene therapy and gene modulation strategies in the organ transplantation setting to prevent rejection, expand the donor pool of available organs, and attenuate ischemia‐reperfusion damage. As we are entering an era of “precision medicine,” the organ transplant field is becoming equipped with the tools necessary to personalize and optimize organs designed specifically to withstand injurious pathways that occur during transplantation, such that the concept of “designer organs” will be a reality in the near future. In this review, we highlight the recent progress using gene knockout and knock‐in strategies used mainly in the context of xenotransplantation. We also discuss advancements in CRISPR‐Cas9 gene editing and RNA interference in relation to organ transplantation. Lastly, we discuss the exciting future implications of customized gene therapy in the transplantation setting, and its ability to potentially create a future where organs intended for transplant are personalized to maximize both graft and patient survival.
How do I know how I am doing? Use of different types of comparison in judgment of well‐being in patients seeking psychological treatment and healthy controls
Authors: Morina Nexhmedin , Meyer Thomas , Sickinghe Marthe 
Published: January 2022

AbstractJudgment of well‐being is formed on the spot, and we know little about its foundations. We aimed at examining the role of comparison standards in informing evaluations of well‐being in a clinical and a nonclinical sample. In a semi‐structured face‐to‐face interview, individuals seeking psychological treatment and healthy control individuals rated how they have been feeling in general and relative to specific comparison standards and were each time invited to substantiate their ratings. Independent coders assessed number, type, direction, and specificity of reported comparisons. When asked to explain why they chose a particular rating of their well‐being, 93% of clinical participants and 61% of nonclinical participants spontaneously reported some type of comparison standard. Both groups reported highest well‐being ratings relative to social and past temporal comparisons and lowest relative to prospective temporal comparison. Furthermore, clinical participants engaged in more upward than downward comparisons, whereas this was not the case for healthy control participants. Our findings suggest that evaluations of well‐being are informed by different comparison types and that individuals with clinical complaints use more comparisons when evaluating their well‐being. The results encourage further investigation of comparative thinking as an underlying mechanism of judgment of well‐being and ill‐being.
Randomised clinical trial: a phase 1b study of GB004, an oral HIF‐1α stabiliser, for treatment of ulcerative colitis
Authors: Danese Silvio , Levesque Barrett G. , Feagan Brian G. , Jucov Alina , Bhandari Bal Raj , Pai Rish K. , Taylor Meadows Kristen , Kirby Brian J. , Bruey Jean‐Marie , Olson Allan , Osterhout Robin , Van Biene Courtney , Ford Julia , Aranda Richard , Raghupathi Kartik , Sandborn William J. 
Published: January 2022

SummaryBackgroundEpithelial barrier dysfunction contributes to a dysregulated intestinal immune response in ulcerative colitis (UC). GB004 is an orally administered, small molecule, gut‐targeted stabiliser of hypoxia‐inducible factor‐1α, a transcription factor with protective roles at the epithelial layer of the inflamed gut.AimsTo evaluate safety, pharmacokinetics, pharmacodynamics and efficacy of GB004 in patients with active UC.MethodsThis double‐blind, placebo‐controlled study randomised patients 2:1 to receive an oral solution of GB004 120 mg or placebo once daily for 28 days. Eligible patients had a Robarts Histopathology Index score ≥4 with neutrophils in the epithelium, total Mayo Clinic score 3‐12, Mayo Clinic endoscopic subscore ≥1, and blood in the stool, despite treatment with 5‐aminosalicylates, corticosteroids or immunosuppressants.ResultsThirty‐four patients were randomised. GB004 120 mg for 28 days was generally well‐tolerated. Adverse events occurred in 27.3% (3/11) and 39.1% (9/23) of patients in the placebo and GB004 groups respectively. Nausea and dysgeusia were most commonly reported in the GB004 group (0% for placebo and 21.7% [5/23] and 13.0% [3/23] respectively for GB004). There were no treatment‐related serious adverse events or deaths. GB004 exhibited minimal accumulation, with higher colonic concentrations relative to plasma. Exploratory pharmacodynamic and efficacy analyses demonstrated GB004 target engagement and numerically higher proportions of patients achieving improvement in multiple measures of disease activity, respectively, at day 28 for GB004 compared to placebo.ConclusionResults from this phase 1b trial support evaluation of the full therapeutic potential of GB004 for the treatment of UC. A phase 2 study (NCT04556383) is ongoing. Clinicaltrials.gov NCT03860896.
Stratigraphic record of continental breakup, offshore NW Australia
Authors: Reeve Matthew T. , Magee Craig , Jackson Christopher A.‐L. , Bell Rebecca E. , Bastow Ian D. 
Published: January 2022

AbstractContinental breakup involves a transition from rapid, fault‐controlled syn‐rift subsidence to relatively slow, post‐breakup subsidence induced by lithospheric cooling. Yet the stratigraphic record of many rifted margins contain syn‐breakup unconformities, indicating that episodes of uplift and erosion interrupt this transition. This uplift has been linked to mantle upwelling, depth‐dependent extension and/or isostatic rebound. Deciphering the breakup processes recorded by these unconformities and their related rock record is challenging because uplift‐associated erosion commonly removes the strata that help constrain the onset and duration of uplift. We examine three major breakup‐related unconformities and the intervening rock record in the Lower Cretaceous succession of the Gascoyne and Cuvier margins, offshore NW Australia, using seismic reflection and borehole data. These data show the breakup unconformities are disconformable (non‐erosive) in places and angular (erosive) in others. Our recalibration of palynomorph ages from rocks underlying and overlying the unconformities shows: (i) the lowermost unconformity developed between 134.98–133.74 Ma (Intra‐Valanginian), probably during the localisation of magma intrusion within continental crust and consequent formation of continent–ocean transition zones (COTZ); (ii) the middle unconformity formed between ca. 134 and 133 Ma (Top Valanginian), possibly coincident with breakup of continental crust and generation of new magmatic (but not oceanic) crust within the COTZs; and (iii) the uppermost unconformity likely developed between ca. 132.5 and 131 Ma (i.e. Intra‐Hauterivian), coincident with full continental lithospheric breakup and the onset of seafloor spreading. During unconformity development, uplift was focussed along the continental rift flanks, likely reflecting flexural bending of the crust and landward flow of lower crust and/or lithospheric mantle from beneath areas of localised extension towards the continent (i.e. depth‐dependent extension). Our work supports the growing consensus that the ‘breakup unconformity’ is not always a single stratigraphic surface marking the onset of seafloor spreading; multiple unconformities may form and reflect a complex history of uplift and subsidence during continent–ocean transition.
A persistent plaque on the back of the hand
Authors: Cameron S. , Ramakrishnan R. , Patel N. P. 
Published: January 2022

Abstract
We report the case of a 75-year-old woman presenting with acrodermatitis chronica atrophicans affecting the right hand dorsum, developing after an insect bite sustained in Greece. Diagnosis was confirmed by serology, PCR and histopathological findings. The plaque resolved following a 3-week course of oral doxycycline.
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A disciplinary divide in the framing of urbanization’s environmental impacts
Authors: Armstrong John H. , Nisi Anna C. , Millard‐Ball Adam 
Published: January 2022

AbstractWe identify a disciplinary divide in how the environmental impacts of urbanization are presented in ecology and urban planning journals. We analyzed the sentiments expressed in 202,900 journal articles and found that articles in ecology journals discuss urbanization three times more negatively relative to urban planning journals. Articles in both disciplines identified the negative local impacts of urban growth on biodiversity, habitat, and other ecological outcomes. However, urban planning research also considered the positive global‐scale benefits of cities in enabling more efficient settlement patterns that reduce greenhouse gas emissions and energy consumption. These diverging perspectives are likely due to the different scales and scopes of the two disciplines, but also because of different counterfactuals: the alternative to urbanization might be car‐dependent exurbs, or simply no new development within the focal study area. Interdisciplinary collaborations may provide a path to reconcile the different perspectives and boost sustainability.
The metabolic triad of non‐alcoholic fatty liver disease, visceral adiposity and type 2 diabetes: Implications for treatment
Authors: Cariou Bertrand 
Published: January 2022

AbstractNon‐alcoholic fatty liver disease (NAFLD) is associated with visceral obesity, insulin resistance, type 2 diabetes (T2D) and has been often considered as the hepatic expression of the metabolic syndrome (MetS). Epidemiological studies highlight a bidirectional relationship of NAFLD with T2D in which NAFLD increases the risk of incident T2D and T2D increases the risk of severe non‐alcoholic steatohepatitis (NASH) and liver fibrosis. Regarding the molecular determinants of NAFLD, we specifically focused in this review on adipocyte dysfunction as a key molecular link between visceral adipose tissue, MetS and NAFLD. Notably, the subcutaneous white adipose tissue expandability appears a critical adaptive buffering mechanism to prevent lipotoxicity and its related metabolic complications, such as NAFLD and T2D. There is a clinical challenge to consider therapeutic strategies targeting the metabolic dysfunction common to NASH and T2D pathogenesis. Strategies that promote significant and sustained weight loss (~10% of total body weight) such as metabolic and bariatric surgery or incretin‐based therapies (GLP‐1 receptor agonists or dual GLP‐1/GIP or GLP‐1/glucagon receptor co‐agonists) are among the most efficient ones. In addition, insulin sensitizers such as PPARγ (pioglitazone) and pan‐PPARs agonists (lanifibranor) have shown some beneficial effects on both NASH and liver fibrosis. Since NASH is a complex and multifactorial disease, it is conceivable that targeting different pathways, not only insulin resistance but also inflammation and fibrotic processes, is required to achieve NASH resolution.
Peri‐operative changes in diastolic function and outcomes in congenital aortic valve surgery
Authors: Pesce Meredith , LaPar Damien , Kalfa David , Bacha Emile , Freud Lindsay 
Published: January 2022

AbstractBackgroundThe ratio of early diastolic mitral inflow velocity (E) to early diastolic mitral annular tissue velocity (e’), or E/e’, is an echocardiographic measure of left ventricular filling pressure. Peri‐operative changes in E/e’ and association with outcomes have been demonstrated in adults undergoing surgery for aortic stenosis (AS). We sought to explore changes in E/e’ and other diastolic indices in the setting of congenital AS surgery and to assess for association with post‐operative outcomes among children and young adults.MethodsA retrospective, single‐center study was performed among patients 6 months to 30 years of age who underwent congenital AS surgery from 2006 to 2018. Tissue Doppler indices were collected from pre‐ and post‐operative echocardiograms. Post‐operative outcomes were reviewed.ResultsSixty‐six subjects with subvalvar (45%), valvar (47%), and supravalvar (8%) AS underwent surgery at a median age of 9.5 years (IQR: 4.0–14.8). Pre‐operatively, the lateral E/e’ ratio was 8.6 (6.7–11.0); 33% had E/e’≥10. Post‐operatively, the lateral e’ decreased to 9.9 cm/s (8.0–11.4), the E/e’ ratio increased to 10.4 (8.3–13.1); and 53% had E/e’≥10 (p‐values < 0.0001, 0.0072, and < 0.001, respectively). Pre‐operative lateral e’ correlated modestly with duration of intubation (ρ = −0.24, p‐value 0.048) and post‐operative lateral e’ correlated modestly with duration of intubation and length of hospital stay (ρ = −0.28 and −0.26, p‐values = 0.02 and 0.04, respectively).ConclusionsChildren and young adults who underwent congenital AS surgery had echocardiographic evidence of diastolic dysfunction pre‐operatively that worsened post‐operatively. Lateral e’ may be a sensitive indicator of impaired ventricular relaxation in these patients and may impact duration of intubation and hospital stay.