bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robust decentralized iterative learning control for large‐scale interconnected systems described by 2‐D Fornasini–Marchesini systems with iteration‐dependent uncertainties including boundary states, disturbances, and reference trajectory
Authors: Wan Kai 
Published: September 2022

SummaryThis article first investigates robust iterative learning control (ILC) problem of a class of large‐scale interconnected systems, which consist of many subsystems described by two‐dimensional linear discrete first Fornasini–Marchesini systems with iteration‐dependent uncertainties arising from not only boundary states, disturbances, but also reference trajectory. A decentralized P‐type ILC law without any information exchanges with other subsystems is proposed such that the ultimate ILC tracking error of each subsystem can converge to a bounded range, the bound of which depends continuously on the bounds of all iteration‐dependent uncertainties considered. Especially, if these iteration‐dependent uncertainties are convergent progressively along the iteration direction, perfect ILC tracking on 2‐D reference trajectory can be obtained. Additionally, a modified ILC law with compensation technique is used to a class of large‐scale interconnected systems composed of many subsystems represented by two‐dimensional linear discrete second Fornasini–Marchesini systems. Two simulation examples are used to demonstrate the effectiveness and validity of the obtained ILC results. Finally, some comparative discussions are given.
Aquatic Skin Enabled by Multi‐Modality Iontronic Sensing
Authors: Cheng Yu , Guo Chenhui , Li Sen , Deng Ka , Tang Jie , Luo Qian , Zhang Shiwu , Chang Yu , Pan Tingrui 
Published: September 2022

AbstractPerception of information is of critical importance for aquatic activities; however, the complex underwater situation faces unique technical challenges to address. Thus, an underwater environment‐incorporated sensing strategy, referred to as aquatic skin, has been introduced with multi‐modality sensing capacities of contact pressure, tactile mapping, depth, temperature, and salinity in a flexible architecture. Remarkably, this has been all achieved by a multi‐modality iontronic sensing principle in an all‐in‐one structural configuration, simplifying the sensor design, material preparation, device fabrication, and signal processing. Particularly, an inverse iontronic sensing mechanism, utilizing complementary elastomeric‐electrode and environmental‐electrode interfaces, is developed for contact pressure detection with exceptional resolution and hydraulic balance. Moreover, a hydrophobic ionic gel with adjustable surface morphologies has been developed as the functional sensing layer for all the units with long‐term stability. Consequently, the aquatic skin can achieve sub‐Pascal resolution of contact pressure detection (0.59 Pa), and sub‐millimeter spatial resolution of tactile mapping (522 pts cm−2) over an extended range of depths (0–40 m), while the environmental influences can be spontaneously eliminated through a self‐compensation process. The aquatic skin is applied toward several representative underwater scenes, including real‐time monitoring of vital/environmental signals, tactile recognition of creatures, and biomechanical analysis of fish swimming.
High‐Performance and Stable Plasmonic‐Functionalized Formamidinium‐Based Quasi‐2D Perovskite Photodetector for Potential Application in Optical Communication
Authors: Wang Tao , Zheng Daming , Zhang Jike , Qiao Jie , Min Changjun , Yuan Xiaocong , Somekh Michael , Feng Fu 
Published: September 2022

AbstractPhotodetectors play an important role in optical communication systems and are essential to achieve high‐fidelity signal transmission. The emerging formamidinium‐based quasi‐2D layered perovskites have attracted attention in the field due to their excellent photoelectric performance and moisture stability. By optimizing film quality and device engineering a high‐performance flexible photodetector based on formamidinium‐based perovskites ((BA)2FAPb2I7) is developed, which shows fast response and excellent air‐stability. By introducing the formamidinium chloride as an additive the quality and the crystallinity of the film are improved. In addition, localized surface plasmonic resonances (LSPRs) are introduced by embedding Au nanostructures on the substrate, the LSPRs, in turn, enhance light and matter interaction, which further increases the performance of the device. The optimized devices show an ultimate response speed ≈9 µs as well as outstanding long‐term environmental stability (environmental conditions > 1000 h). Achieving such high dynamic range and stability is to the best of authors knowledge rarely reported. The device shows the highest responsivity of 2.3 A W−1, detectivity of 3.2 × 1012 Jones, and outstanding flexibility stability. Finally, the prepared photodetector is successfully integrated into an optical communication system and tested. The results suggest that formamidinium‐based quasi‐2D perovskite photodetectors have great potential in optical communication applications.
A Noble AuPtAg‐GOx Nanozyme for Synergistic Tumor Immunotherapy Induced by Starvation Therapy‐Augmented Mild Photothermal Therapy
Authors: Wang Man , Chang Mengyu , Zheng Pan , Sun Qianqian , Wang Guangqiang , Lin Jun , Li Chunxia 
Published: September 2022

AbstractNotwithstanding immune checkpoint blocking (ICB) therapy has made eminent clinical breakthroughs, overcoming immunologically “cold” tumors remains challenging. Here, a cascade potentiated nanomodulator AuPtAg‐GOx is engineered for boosting immune responsiveness. Upon 1064 nm laser irradiation, AuPtAg‐mediated mild photothermal therapy (PTT) activates cytotoxic T lymphocytes and reverses the immunogenic “cold” tumor microenvironment. Further, to amplify the thermal sensitivity of tumor cells, glucose oxidase (GOx) is introduced to suppress the production of heat shock proteins, thereby promoting mild photothermal therapy. Complementarily, AuPtAg nanozymes with catalase‐like activity can ameliorate tumor hypoxia, significantly improving the GOx activity. As a result, the combination of AuPtAg‐GOx with self‐augmented photothermal ability and PD‐L1 antibody can further escalate the antitumor efficacy. The AuPtAg‐GOx‐based synergistic starvation therapy, mild PTT, and immunotherapy cascade enhancement therapy strategy can be a favorable tool to effectively kill cancer cells.
Fibril‐Type Textile Electrodes Enabling Extremely High Areal Capacity through Pseudocapacitive Electroplating onto Chalcogenide Nanoparticle‐Encapsulated Fibrils
Authors: Chang Woojae , Nam Donghyeon , Lee Seokmin , Ko Younji , Kwon Cheong Hoon , Ko Yongmin , Cho Jinhan 
Published: September 2022

AbstractEffective incorporation of conductive and energy storage materials into 3D porous textiles plays a pivotal role in developing and designing high‐performance energy storage devices. Here, a fibril‐type textile pseudocapacitor electrode with outstanding capacity, good rate capability, and excellent mechanical stability through controlled interfacial interaction‐induced electroplating is reported. First, tetraoctylammonium bromide‐stabilized copper sulfide nanoparticles (TOABr‐CuS NPs) are uniformly assembled onto cotton textiles. This approach converts insulating textiles to conductive textiles preserving their intrinsically porous structure with an extremely large surface area. For the preparation of textile current collector with bulk metal‐like electrical conductivity, Ni is additionally electroplated onto the CuS NP‐assembled textiles (i.e., Ni‐EPT). Furthermore, a pseudocapacitive NiCo‐layered double hydroxide (LDH) layer is subsequently electroplated onto Ni‐EPT for the cathode. The formed NiCo‐LDH electroplated textiles (i.e., NiCo‐EPT) exhibit a high areal capacitance of 12.2 F cm−2 (at 10 mA cm−2), good rate performance, and excellent cycling stability. Particularly, the areal capacity of NiCo‐EPT can be further increased through their subsequent stacking. The 3‐stack NiCo‐EPT delivers an unprecedentedly high areal capacitance of 28.8 F cm−2 (at 30 mA cm−2), which outperforms those of textile‐based pseudocapacitor electrodes reported to date.
LCK‐Mediated RIPK3 Activation Controls Double‐Positive Thymocyte Proliferation and Restrains Thymic Lymphoma by Regulating the PP2A‐ERK Axis
Authors: Hwang Sung‐Min , Ha Yu‐Jin , Koo Gi‐Bang , Noh Hyun‐Jin , Lee A‐Yeon , Kim Byeong‐Ju , Hong Sun Mi , Morgan Michael J. , Eyun Seong‐il , Lee Dakeun , Roe Jae‐Seok , Lee Youngsoo , Kim You‐Sun 
Published: September 2022

AbstractReceptor‐interacting protein kinase 3 (RIPK3) is the primary regulator of necroptotic cell death. RIPK3 expression is often silenced in various cancer cells, which suggests that it may have tumor suppressor properties. However, the exact mechanism by which RIPK3 negatively regulates cancer development and progression remains unclear. This report indicates that RIPK3 acts as a potent regulator of the homeostatic proliferation of CD4+CD8+ double‐positive (DP) thymocytes. Abnormal proliferation of RIPK3‐deficient DP thymocytes occurs independently of the well‐known role for RIPK3 in necroptosis (upstream of MLKL activation), and is associated with an incidental thymic mass, likely thymic hyperplasia. In addition, Ripk3‐null mice develop increased thymic tumor formation accompanied by reduced host survival in the context of an N‐ethyl‐N‐nitrosourea (ENU)‐induced tumor model. Moreover, RIPK3 deficiency in p53‐null mice promotes thymic lymphoma development via upregulated extracellular signal‐regulated kinase (ERK) signaling, which correlates with markedly reduced survival rates. Mechanistically, lymphocyte‐specific protein tyrosine kinase (LCK) activates RIPK3, which in turn leads to increases in the phosphatase activity of protein phosphatase 2 (PP2A), thereby suppressing hyper‐activation of ERK in DP thymocytes. Overall, these findings suggest that a RIPK3‐PP2A‐ERK signaling axis regulates DP thymocyte homeostasis and may provide a potential therapeutic target to improve thymic lymphoma therapies.
Impacts of the Lattice Strain on Perovskite Light‐Emitting Diodes
Authors: Wang Heyong , Chen Zhan , Tian Fuyu , Zheng Guanhaojie , Wang Hongguang , Zhang Tiankai , Qin Jiajun , Gao Xingyu , van Aken Peter A. , Zhang Lijun , Liu Xiao‐Ke , Gao Feng 
Published: September 2022

AbstractThe development of perovskite light‐emitting diodes (PeLEDs) with both high efficiency and excellent stability remains challenging. Herein, a strong correlation between the lattice strain in perovskite films and the stability of resulting PeLEDs is revealed. Based on high‐efficiency PeLEDs, the device lifetime is optimized by rationally tailoring the lattice strain in perovskite films. A PeLED with a high peak external quantum efficiency of 18.2% and a long lifetime of 151 h (T70, under a current density of 20 mA cm−2) is realized with a minimized lattice strain in the perovskite film. In addition, an increase in the lattice strain is found during the long‐time device stability test, indicating that the degradation of the local perovskite lattice structure could be one of the degradation mechanisms for long‐term stable PeLEDs.
Incorporating genetics services into adult kidney disease care
Authors: Bogyo Kelsie , Vena Natalie , May Halie , Rasouly Hila Milo , Marasa Maddalena , Sanna‐Cherchi Simone , Kiryluk Krzysztof , Nestor Jordan , Gharavi Ali 
Published: September 2022

AbstractStudies have shown that as many as 1 in 10 adults with chronic kidney disease has a monogenic form of disease. However, genetic services in adult nephrology are limited. An adult Kidney Genetics Clinic was established within the nephrology division at a large urban academic medical center to increase access to genetic services and testing in adults with kidney disease. Between June 2019 and December 2021, a total of 363 patients were referred to the adult Kidney Genetics Clinic. Of those who completed genetic testing, a positive diagnostic finding was identified in 27.1%, a candidate diagnostic finding was identified in 6.7% of patients, and a nondiagnostic positive finding was identified in an additional 8.6% of patients, resulting in an overall yield of 42.4% for clinically relevant genetic findings in tested patients. A genetic diagnosis had implications for medical management, family member testing, and eligibility for clinical trials. With the utilization of telemedicine, genetic services reached a diverse geographic and patient population. Genetic education efforts were integral to the clinic's success, as they increased visibility and helped providers identify appropriate referrals. Ongoing access to genomic services will remain a fundamental component of patient care in adults with kidney disease.
Highly Chemoselective Transformation of Secondary Propargylic Alcohols with (EtO)2P(O)SH
Authors: Du Sha , Zhou Zhao‐Zhao , Jin Fengyan , Liu Xiaofang , Zhou Lijun , Tian Wan‐Fa , Huang Haiyang , Song Xian‐Rong , Xiao Qiang 
Published: September 2022

AbstractA practical and environmentally friendly approach is presented for the efficient construction of propargyl organothiophosphates and allenyl organothiophosphates from easily prepared secondary propargylic alcohols andO,O‐diethyl phosphorothioic acid [(EtO)2P(O)SH]. The reaction proceeds smoothly in moderate to excellent yields without additional acid promoters or additives under mild conditions with water as the only by‐product. The divergent products are selectively obtained depending on substrates bearing different substituents on the aromatic ring. Notably, the developed reaction system can be scaled up to gram quantities.
Hierarchical Assembly of a Micro‐ and Macroporous Hydrogen‐Bonded Organic Framework with Tailored Single‐Crystal Size
Authors: Halliwell Christopher A. , Dann Sandra E. , Ferrando‐Soria Jesus , Plasser Felix , Yendall Keith , Ramos‐Fernandez Enrique V. , Vladisavljević Goran T. , Elsegood Mark R. J. , Fernandez Antonio 
Published: September 2022

AbstractPorous organic molecular materials represent an emergent field of research in Chemistry and Materials Science due to their unique combination of properties. To enhance their performance and expand the number of applications, the incorporation of hierarchical porosity is required, as exclusive microporosity entails several limitations. However, the integration of macropores in porous organic molecular materials is still an outstanding challenge. Herein, we report the first example of a hydrogen‐bonded organic framework (MM‐TPY) with hierarchical skeletal morphology, containing stable micro‐ and macroporosity. The crystal size, from micro to centimetre scale, can be controlled in a single step without using additives or templates. The mechanism of assembly during the crystal formation is compatible with a skeletal crystal growth. As proof of concept, we employed the hierarchical porosity as a platform for the dual, sequential and selective co‐recognition of molecular species and microparticles.
The role of community involvement in sustainable tourism strategies: A social and environmental innovation perspective
Authors: Sharma Vivek , Bhat Dada Ab Rouf 
Published: September 2022

AbstractSocial innovation and environmental innovation is a fast‐growing phenomenon. More and more businesses are trying to understand how social and environmental innovation can help their business model. The purpose of this paper is to examine the contribution of community involvement toward social and environmental innovation to achieve sustainable tourism development. Perceptions of 650 local community members of different tourist destinations of Jammu and Kashmir have been used to meet the objectives of the study. The structural equation modelling (SEM) technique has been used for determining the structural estimates between constructs with the help of Statistical Package for the Social Science (SPSS) and Analysis of Moment Structure (AMOS) software. Hypothesis testing revealed a positive impact of community involvement on social and environmental innovation. The results also depicted a positive impact of social and environmental innovation on sustainable tourism development.
Identification of nine mutant genes and establishment of three prediction models of organ tropism metastases of non‐small cell lung cancer
Authors: Chen Shuchen , Huang Wanyi , Liu Zhenzhen , Jin Meizi , Li Jielin , Meng Lihui , Li Ting , Diao Yuzhu , Gao Hong , Hong Chengyu , Zheng Jian , Li Fei , Zhang Yue , Bi Dan , Teng Lin , Li Xiaoling 
Published: September 2022

AbstractBackgroundMost Non‐small cell lung cancer (NSCLC) patients tend to have metastases at the initial diagnosis. However, limited knowledge has been established regarding which factors, are associated with its metastases. This study aims to identify more biomarkers associated with its organ tropism metastasis and to establish models for prediction of its metastatic organs.MethodsWe performed targeted next‐generation sequencing (NGS) to detect genes related to lung cancer in 272 patients with primary advanced NSCLC from Northeast China. We adopted Fisher test, multivariate logistic regression analysis to identify metastasis‐related gene mutations and to establish prediction models.ResultsMutations of EGFR (p = 0.0003, OR = 2.554) (especially EGFR L858R [p = 0.02, OR = 2.009]), ATM (p = 0.008, OR = 11.032), and JAK2 (p = 0.009, OR = Inf) were positively and of TP53 exon4mut (p = 0.001, OR = 0.173) was negatively correlated with lung metastasis, and those of CSF1R (p = 0.01, OR = Inf), KIT (p = 0.03, OR = 4.746), MYC (p = 0.05, OR = 7.938), and ERBB2 (p = 0.02, OR = 2.666) were positively correlated with pleural dissemination; those of TP53 (p = 0.01, OR = 0.417) was negatively, while of SMAD4 (p = 0.03, OR = 4.957) was positively correlated with brain metastasis of NSCLC. Additionally, smoking history (p = 0.004, OR = 0.004) was negatively correlated with pleural dissemination of NSCLC. Furthermore, models for prediction of lung metastasis (AUC = 0.706), pleural dissemination (AUC = 0.651), and brane metastasis (AUC = 0.629) were established.ConclusionTaken together, this study revealed nine mutant genes and smoking history associated with organ tropism metastases of NSCLC and provided three models for the prediction of metastatic organs. This study enables us to predict the organs to which non‐small cell lung cancer metastasizes before it does develop.
Study of SOX combined with intraperitoneal high‐dose paclitaxel in gastric cancer with synchronous peritoneal metastasis: A phase II single‐arm clinical trial
Authors: Tu Li , Zhang Weihan , Ni Lu , Xu Zihan , Yang Kun , Gou Hongfeng , Zhu Qing , Liu Ming , Yang Yu , Hu Jiankun , Qiu Meng 
Published: September 2022

AbstractBackgroundIntraperitoneal paclitaxel is proved to be efficient for peritoneal metastasis of gastric cancer. It remains uncertain the efficacy and safety of the triplets regimen which combined intraperitoneal high‐dose paclitaxel with systemic SOX in gastric cancer patients with peritoneal metastasis. This study aimed to evaluate the efficacy and safety of intraperitoneal administration of high‐dose paclitaxel, intravenous oxaliplatin and S‐1 in patients with peritoneal metastatic gastric cancer.MethodsThis single‐center, prospective, single‐arm phase II study was conducted between January 2017 and May 2019 in West China Hospital, Sichuan University. Patients diagnosed with primary gastric cancer by histopathology and confirmed synchronous peritoneal metastasis were enrolled. This study aimed to evaluate efficacy and safety of intraperitoneal administration of high‐dose paclitaxel (80 mg/m2, d1), intravenous oxaliplatin (100 mg/m2, d1), and S‐1 (80 mg/m2, d1‐14) of patients. The primary endpoint was 1‐year overall survival rate, and the second endpoints were progression‐free survival (PFS), overall survival (OS), overall response rate (ORR), disease control rate (DCR) and adverse events.ResultsIn this single‐arm phase II clinical trial, 49 patients received SOX combined intraperitoneal high‐dose paclitaxel treatment. One‐year survival rate was 81.6% (95% CI, 68.6–90.0%). Median PFS and OS were 6.50 months (95% CI, 2.89–10.11) and 16.9 months (95% CI, 13.58 to 20.22), respectively; ORR was 55.3% (95% CI, 41.3–68.6) and DCR was 76.6% (95% CI, 62.8–86.4). Thirteen patients underwent second laparoscopic detection, but only nine ultimately underwent radical gastrectomy. Subgroup analysis showed that sPCI ≤12 was a good index for a favorable prognosis. The most frequent grade 3/4 toxicities were neutropenia (40.8%), anemia (22.4%), leukopenia (18.4%), nausea (14.3%), and vomiting (12.2%). None of the patients had any intraperitoneal catheter‐related complications.ConclusionsIntraperitoneal high‐dose paclitaxel with systemic SOX is an effective and tolerable first‐line treatment for patients with peritoneal metastatic gastric cancer and patients with sPCI≤12 scores might be recommended crowd for this regimen as conversion therapy.
Group‐based processes as a framework for understanding the working alliance in therapy
Authors: Lee Georgina C. , Platow Michael J. , Cruwys Tegan 
Published: September 2022

AbstractObjectiveThe working alliance construct faces persistent issues with conceptualisation. We present a social identity analysis of working alliance. Here, we examine the links between alliance, the focal shared sense of “us” in social identification and identity leadership scholarship, and research on the role of “voice” (i.e., being provided with the opportunity to state one's own perspective to others) in enabling procedural justice. We hypothesised that working alliance would be predicted by group processes (i.e., social identification, identity leadership and procedural justice) and serve as an important mediator through which these processes enable desired therapeutic and organisational outcomes.MethodAn online experiment sampled participants recently in therapy for a diagnosed mental disorder and recently employed. Participants were randomly assigned to recall either a therapy session or work meeting in which they had received or not received voice.ResultsSocial identification, identity leadership and procedural justice were found to account for approximately 70% of variance in working alliance. Working alliance, in turn, predicted positive affect, negative affect and satisfaction, in addition to mediating the relationship between group‐based processes and these outcomes.ConclusionThese novel findings suggest that group‐based processes are useful for conceptualising the working alliance in therapy, by both enhancing theory and providing practical clinical strategies for facilitating alliance.