bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prisms in the treatment of diplopia with strabismus of various etiologies
Authors: Anilkumar Sasikala E , Narendran Kalpana 
Published: February 2022

Purpose:
We aimed to study the success of prism in regard to diplopia resolution score and associated factors in patients presenting with symptomatic diplopia arising from various etiologies.

Methods:
In this descriptive, retrospective study diplopia resolution among 31 patients who were prescribed prism were analyzed.

Results:
Fifty-four patients were evaluated for diplopia and 31 were included for the study done over 3 years. The mean follow-up was 15 months. Esotropia, exotropia, and hypertropia were seen in 39%, 51%, and 19.4% of patients, respectively. Furthermore, 71% received Fresnel prism and 29% were given ground glass prism. The mean prism power prescribed was 13.3 PD. 87% had complete resolution of diplopia; 96.8% continued usage of prism. High success rates were seen among patients with decompensated strabismus, sixth and fourth nerve palsy. Horizontal prism and oblique prism in the form of Fresnel prism yielded complete resolution of diplopia (P = 0.028). There was no association between the success of prism and etiology (P 0.058), history of trauma (P = 0.212), and type of deviation (P = 0.387). The study showed that oblique Fresnel prism can be considered for combined deviation.

Conclusion:
Our study showed prism to be effective in alleviating diplopia over a varied range of etiologies.
Epitope Identification and Designing a Potent Multi-epitope Vaccine Construct against SARS-CoV-2 Including the Emerging Variants
Authors: Srinivasan Sivasubramanian , Selvaraj Gracy Fathima , Gopalan Vidya , Padmanabhan Padmapriya , Ramesh Kiruba , Govindan Karthikeyan , Chandran Aswathi , Dhandapani Prabu , Krishnasamy Kaveri , Kitambi Satish Srinivas 
Published: February 2022

Introduction:
The emergence of a novel coronavirus in China has turned into a SARS-CoV-2 pandemic with high fatality. As vaccines are developed through various strategies, their immunogenic potential may drastically vary and thus pose several challenges in offering immune responses against the virus.

Methods:
In this study, we adopted an immunoinformatics-aided approach for developing a new multi-epitope vaccine construct (MEVC). In silico approach was taken for the identification of B-cell and T-cell epitopes in the Spike protein, for MEVC various cytotoxic T-lymphocyte, helper T-lymphocyte, and B-cell epitopes with the highest affinity for the respective HLA alleles were assembled and joined by linkers.

Results:
The computational data suggest that the MEVC is nontoxic, nonallergenic and thermostable and elicit both humoral and cell-mediated immune responses. Subsequently, the biological activity of MEVC was assessed by bioinformatic tools using the interaction between the vaccine candidate and the innate immune system receptors TLR3 and TLR4. The epitopes of the construct were analyzed with that of the strains belonging to various clades including the emerging variants having multiple unique mutations in S protein.

Conclusions:
Due to the advantageous features, the MEVC can be tested in vitro for more practical validation and the study offers immense scope for developing a potential vaccine candidate against SARS-CoV-2 in view of the public health emergency associated with COVID-19 disease caused by SARS-CoV-2.
The frequency of osteoporosis in patients with predialysis chronic renal failure and the factors affecting the development of osteoporosis
Authors: Karatas A , Erdem E , Arıcı YK , Canakci E , Turkmen E , Turker NT 
Published: February 2022

ABSTRACT

Background:
Osteoporosis is a common public health problem in chronic kidney patients. The risk factors for osteoporosis in patients with nondialysis CKD have not been fully investigated. It is not known exactly whether the risk factors of osteoporosis in the general population are also valid for the nondialysis CKD patients. Aims: This study aims to determine the frequency of osteoporosis and the risk factors for osteoporosis in nondialysis CKD patients.

Patients and Methods:
Our study was performed with 283 nondialysis stage 3-5 CKD patients. According to the BMD results, the patients were classified into groups as normal, osteopenia and osteoporosis according to World Health Organization criteria. Monocyte/high-density lipoprotein-cholesterol ratio (MHR), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) were calculated individually for all cases.

Results:
According to our BMD results, 67 (24%) patients were found to have osteoporosis. In the osteoporosis patient group, compared to the normal BMD group, females were higher and the mean age was higher (P = 0.025, P = 0.028). Body mass index (BMI) and eGFR were lower in the osteoporosis group (P = 0.013). Parathyroid Hormone and Platelet-to-lymphocyte ratio in the patients in the osteoporosis group was higher than of those in the normal group (P = 0.026, P = 0.035). In the multivariate logistic regression analysis, advanced age, female gender, and low BMI were determined as independent risk factors for the development of osteoporosis in nondialysis CKD patients.

Conclusion:
Advanced age, female gender and low BMI are the risk factors for osteoporosis in nondialysis CKD patients. It may be a rational approach to measure BMD for the diagnosis of osteoporosis in nondialysis CKD patients who are elderly, female and have low BMI.
Conhecimento atual sobre os tentaculitoideos devonianos das bacias do Amazonas e Parnaíba, Brasil, depositados em instituições brasileiras
Authors: Comniskey Jeanninny Carla , Ghilardi Renato Pirani , Bosetti Elvio Pinto 
Published: February 2022

Os tentaculitoideos são encontrados em afloramentos do Devoniano das bacias do Paraná (Formações Ponta Grossa e São Domingos), Amazonas (Formações Maecuru e Ererê) e Parnaíba (Formação Cabeças). Foram analisadas 39 amostras de coleções científicas provenientes do Devoniano Médio das bacias do Amazonas e do Parnaíba, com principal objetivo de realizar uma revisão sistemática e refinar o conhecimento acerca da distribuição estratigráfica e paleogeográfica do grupo. As espécies encontradas foram: Tentaculites trombetensis, Tentaculites stubeli, Tentaculites eldredgianus, Tentaculites oseryi e Styliolina clavulus. As espécies T. eldredgianus, T. trombetensis e S. clavulus foram encontradas em afloramentos do Eifeliano até o Givetiano, enquanto T. oseryi apenas no Givetiano e T. stubeli no Eifeliano. As primeiras ocorrências de tentaculitoideos para a América do Sul são registradas no Siluriano, o que corrobora a hipótese de que durante o Siluriano Inferior ocorreu um grande aumento da diversidade e quantidade de tentaculitoideos no mundo.
Distribuição de metais pesados e isótopos de Pb em sedimentos do rio Amapari, setor de Pedra Branca do Amapari – Porto Grande, Amapá, Brasil
Authors: Silva Danúbia Tavares da , Lafon Jean Michel , Corrêa José Augusto Martins 
Published: February 2022

Este trabalho apresenta dados mineralógicos e geoquímicos de metais pesados e de isótopos de Pb em sedimentos recentes, provenientes do rio Amapari e alguns de seus tributários, na região da Serra do Navio, parte central do estado do Amapá. Os sedimentos têm composição mineralógica formada essencialmente por quartzo, caulinita, muscovita e gibbsita, e apresentam grande heterogeneidade geoquímica e isotópica de Pb. Os resultados geoquímicos mostraram que os sedimentos têm altos teores de metais pesados e sofreram os mesmos processos de enriquecimento para todos os metais investigados. Os metais estão principalmente associados a minerais de Fe, e os argilominerais tiveram um papel secundário na concentração desses metais. A variação significativa na composição isotópica do Pb permitiu construir uma isócrona no diagrama 207Pb/204Pb vs. 206Pb/204Pb, com idade de 2169 ± 140 Ma, indicando que os sedimentos são provenientes essencialmente das unidades paleoproterozoicas (rochas supracrustais e granitoides associados), sem contribuição significativa das unidades do embasamento arqueano. Não foi evidenciada correlação entre a localização dos pontos em relação às áreas com atividades de mineração e aos teores dos metais.
First record of the genus Cranichis Sw. (Orchidaceae) for the state of Pará, Brazil
Authors: Hall Climbiê Ferreira , Koch Ana Kelly , Francener Augusto , De Barros Fábio 
Published: February 2022

Cranichis is a Neotropical genus with about 53 species, five of which are known from Brazil. Cranichis muscosa is only known in Brazil from the states of Amazonas, Paraná and São Paulo. In this paper, a new record of C. muscosa is presented for the state of Pará, expanding the occurrence of the species.
Candida auris case in Karachi, a public health threat ahead
Authors: Fauzia Imtiaz  , Moeez Tariq  , Syed Noor Ul Hasan  
Published: February 2022

Candida auris a multidrug- resistant nosocomial fungal pathogen is an emerging global public health threat. Since its discovery in Japan in 2009, the fungus has now affected more than 40 countries worldwide. It is a haploid microscopic fungus belonging to the Metschnikowiaceae family in the Candida/Clavispora clade. (1).
More commonly colonizing the skin, Candida auris is isolated from multiple infection sites and is generally acquired from hospital environments. The risk factors for contracting the fungus are immunodeficiency, diabetes mellitus, elderly age, previous surgery, indwelling medical device and the use of broad- spectrum anti-microbial therapy (1,2). Unlike other Candida species, Candida auris is usually thermotolerant and osmotolerant which helps the pathogen to withstand environmental stresses (2). The strains of Candida auris are resistant to common anti-fungal drugs like Fluconazole, Amphotericin B and rarely Echinocandin too, making it a significant and notorious member among other Candida species (1,2). According to the Center for Disease Control and Prevention, Candida auris causes infections of bloodstream, ear and wounds. The most common symptoms of invasive infection by Candida auris are fever and chills that do not remit on antibiotic therapy. Diagnosis is mainly based on blood and urine cultures. (3).
Recently, a case was presented in a Public sector tertiary care hospital of Karachi in the paediatric age group. The patient was a six year old boy suffering with meningitis and septicemia and was admitted first in the ICU and subsequently in the ward. The patient got discharged after getting routine empirical therapies. The blood and urine culture taken during the stay was positive for Candida auris.
Previously, an outbreak reported in ICU patients in Rawalpindi in 2018 was controlled by adopting staunch measures (4). There is a paucity of recording and reporting outbreaks to the concerned health authorities in P.akistan Moreover, lack of hygiene practices followed by patients and the attendants, and poor infection control measures have caused such outbreaks.
Pakistan, a developing country with minimal resources reserved for health, coped with three invasive waves of the deadly Coronavirus/COVID-19 pandemic. Candida auris manifests itself as a serious public health threat for the country. The policymakers should take swift actions related to this. Some steps that we recommend are that Candida auris infection should be declared as a prioritized notifiable disease and measures instituted for prompt reporting.
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Talabalarda kreativlik sifatlarini rivojlantirish
Authors: Siddiqov Baxtiyor , Аbdullaev Erkin 
Published: February 2022

Ushbu maqolada kreativlikning mohiyati, kreativlik atamasi, kreativlik sifatlarini rivojlantirishga ta’sir etuvchi ijtimoiy omillar, shaxsning faolligi, ta’lim oluvchilarda tanqidiy, kreativ tafakkurni shakllantirish yo’llari va shakllari, tafakkurning egiluvchanligi, kreativlikning mezonlari bayon etilgan.
Fransiyada ikkinchi imperiya davrida sanoatning ko‘tarilishi va moliyaviy rivojlanish
Authors: Boltayeva Moxichexra , Ortiqov Olim 
Published: February 2022

Maqolada XIX asrning ikkinchi yarmida Fransiyada ikkinchi imperiyaning sanoat o‘zgarishlari va moliyaviy o‘zgarishlar haqida so‘z boradi. Bu davrning asosiy voqealari sifatida Yevropada yuz bergan sanoat to‘ntarishlari va ularning davlatlarning siyosiy hayotga ta’siri kabi voqealarni olish mumkin. Maqolada asosiy ko‘rsatilgan yangiliklardan biri bu Fransiya sanoat inqilobining siyosiy inqilob bilan birgalikdagi uzviy bog‘liqligidir.
Zamonaviy o’qitish metodlari orqali iqtidorli o’quvchilarni tarbiylash va rivojlantirish
Authors: Aripov Zoirjon , Saydumarova Marhabo 
Published: February 2022

Ushbu maqolada zamonaviy o’qitish metodlari, iqtidorli o’quvchilarni tarbiyalash va rivojlantirish, interfaol o’qitish usullari, didaktik va uslubiy talablar, funksional talablar, o’qitishning qiziqtiruvchi metodlari, didaktik o’yinli texnologiyalar bayon etilgan.
Кучли ижтимоий ҳимоя - давр талаби
Authors: Зиядуллаев Махмуджон 
Published: February 2022

Ушбу мақолада ижтимоий ҳимоянинг ҳуқуқий асослари, Республикамизда пенсионерларни ижтимоий қўллаб-қувватлашни янада кучайтириш, имконияти чекланган шахсларга, қариялар ва кекса ёшдагиларга ҳар томонлама ғамхўрлик қилиш, фуқароларнинг давлат пенсия таъминоти тизимини такомиллаштириш ва соҳасида мавжуд муаммоларни бартараф этиш юзасидан амалга оширилган чора-тадбирлар ёритиб берилган.
Шунингдек, охирги йилларда пенсия таъминоти бўйича амалга оширилган ўзгаришлар, пенсионерларга яратилган қулай шарт – шароитлар, хусусан 2021 йил 1 июндан амалиётга жорий қилинган пенсия соҳасидаги ўзгаришларнинг мазмун моҳиятлари ва пенсия таъминоти бўйича таклифлар илгари сурилган.
Шимолий Бақтриянинг илк темир даври ёдгорликларидан топилган илк зардуштийликка оид моддий маданият намуналари
Authors: Хамидов Одилжон 
Published: February 2022

Зардуштийлик энг қадимги динлардан бўлиб, бу дин эр.авв. VII–VI асрларда даставвал Ўрта Осиёда-Хоразм воҳа-сида пайдо бўлган. Зардуштийликка оид моддий маданият намуналарини чуқур илмий таҳлил қилиш ушбу диннинг моҳиятини тўлиқ очиб беришга хизмат қилади. Ушбу мақолада Шимолий Бақтриянинг илк темир даври ёдгор-ликларидан топилган ушбу динга оид митти ўғир ва ўғирдасталар ҳамда уларнинг Ўрта Осиё бўйлаб тарқалиш географияси ҳақидаги тарихий-археологик маълумотлар ёритилган.
La importancia de los Principios del Derecho Ambiental en la Política Ambiental Municipal
Authors: Zea Concha Juan Sebastian 
Published: February 2022

Los Principios del Derecho Ambiental son la columna vertebral del Sistema Legal Ambiental en el Perú por esta razón constituyen un fundamento esencial para elaborar Políticas Públicas a nivel del gobierno local Municipal por tal motivo es de vital importancia tener esta base legal sólida, de esta forma, para toda política pública es necesario que explícitamente en su elaboración se tenga siempre presente dichos principios ya que su importancia es fomentar el Desarrollo sostenible de la sociedad.
A new type of auxiliary structure for tunnel-surrounding rock support – composite cantilever support structure
Authors: Qu Jun , Xue Qilong , Bai Shixin , Li Yazhe 
Published: February 2022

Abstract. The deformation and damage mechanisms of tunnel-surrounding rock masses have always been a major problem in underground engineering, and studying these mechanisms plays an important role in preventing this kind of geological disaster. Against the background of the above project, in this paper, we propose a new type of support structure: a composite cantilever support structure. Studies involving the numerical calculation and application of this support structure are carried out, and the conducted investigation indicates that (1) for a relatively broken rock mass, the composite cantilever support structure can effectively restrain the deformation of the tunnel-surrounding rock mass, (2) through numerical calculation, the appropriate design parameters of the support structure are obtained, and (3) the design parameters and design structure of the composite cantilever support structure must be further studied and verified under complex geological conditions by engineering.
PENGARUH DISTRES EMOSIONAL TERHADAP PERILAKU MEROKOK REMAJA DI INDONESIA (ANALISIS DATA RISKESDAS 2013)
Authors: Fauziah Diah Adni , Ronoatmodjo S. , Riono P. 
Published: February 2022

Latar Belakang Prevalensi merokok pada remaja lebih tinggi dibandingkan kelompok dewasa. Salah satu yang menyebabkan perilaku merokok remaja adalah masa transisi menjadi dewasa yang psikologisnya cenderung tidak stabil. Hasil Global Youth Tobacco Survey tahun 2014 melaporkan konsumsi tembakau pada remaja sebesar 20,3%, yaitu 19,4% perokok saat ini dan 2,1% bukan perokok. Distres emosional pada remaja dilaporkan memiliki hubungan terhadap perilaku merokok. Penelitian ini mempelajari besar efek distres emosional terhadap perilaku merokok remaja di Indonesia.
Metode Data survei Riskesdas 2013 dianalisis dengan menggunakan regresi logistik berganda dengan mempertimbangkan desain survei. Variabel confounding yaitu umur, jenis kelamin, tempat tinggal, pendidikan kepala rumah tangga, sosial ekonomi keluarga, dan anggota rumah tangga yang merokok.
Hasil Hasil penelitian menunjukkan bahwa odds remaja yang merokok mengalami distres emosional sebesar 1,82 kali dibandingkan dengan remaja yang tidak merokok setelah dikontrol oleh variabel umur, pendidikan kepala rumah tangga, tempat tinggal, dan sosial ekonomi (OR=1,82; 95% CI 1,66-1,99).
Kesimpulan Odds remaja yang merokok mengalami distres emosional sebesar 1,82 kali dibandingkan dengan remaja yang tidak merokok setelah dikontrol oleh variabel umur, pendidikan kepala rumah tangga, tempat tinggal, dan sosial ekonomi
Kata kunci: perilaku merokok, distres, remaja
EMOTIONAL DISTRESS EFFECT TO ADOLESCENT’S SMOKING BEHAVIOR IN INDONESIA (NATIONAL HEALTH RESEARCH 2013)
ABSTRACT
Background Smoking prevalence in adolescent is higher than adult. One of caused is transition fase among adolescent in unstabil psychology. In 2014, Global Youth Tobacco Survey reported the current use of any tobacco product by youth was 20,3%, of which 19,4% were current tobacco smokers and 2,1% were current smokeless tobacco users. Emotional distress in adolescent associated with smoking behaviour. The aimed was to study emotional distress effect to smoking behavior among adolescent in Indonesia.
Method National Health Research Data Survey in 2013 was analyzed by using multiple logistic regression.
Result Result showed that odds adolescent smoker had to emotional distress 1,82 than adolescent nonsmoker adjusted by age, household education, addressed and family’s socio economic. (OR=1,82; 95% CI 1,66-1,99).
Conclusion Odds Adolescent smoker had to emotional distress 1,82 than adolescent nonsmoker adjusted by age, household education, addressed and family’s socio economic.
Keyword : Smoking, Behaviour, Distress, Adolescent
SKRINING FITOKIMIA EKSTRAK CARICA PAPAYA RADIX, PIPER ORNATUM FOLIUM DAN NEPHELIUM LAPPACEUM SEMEN ASAL KALIMANTAN SELATAN
Authors: Zaini Muhammad , Shofia Vivi 
Published: February 2022

Penyakit Diabetes Mellitus merupakan penyakit dengan prevalensi tinggi dan menduduki peringkat 10 besar di dunia termasuk di Indonesia. Permasalahan besar yang dihadapi dunia kesehatan dewasa ini adalah Diabetes Mellitus tidak bisa disembuhkan secara total dengan obat antihiperglikemik konvensional. Penelitian perlu dilakukan dalam hal menelusuri potensi bahan alam yang biasa digunakan oleh masyarakat Kalimantan berdasarkan skrining fitokimia dari beberapa tumbuhan yang secara empiris digunakan sebagai antidiabetes yaitu Carica papaya radix (CPR), Nephelium lappaceum semen (NLS) dan Piper ornatum folium (POF). Tumbuhan obat yang diperoleh dilakukan ekstraksi maserasi dan diidentifikasi golongan senyawa dan profil kromatografinya.Kegiatan penelitian ini meliputi: 1) Pengambilan sampel tumbuhan,2) Pembuatan simplisia uji, 3) Pembuatan ekstrak etanol tumbuhan, 4) Uji kualitatif kandungan kimia tumbuhan, dan 5) Identifikasi secara kromatografi lapis tipis.
Hasil dari penelitian dipilih dan dilakukan pengujian terhadap 3 ekstrak yaitu Carica papaya radix, Nephelium lappaceum semen dan Piper ornatum folium. Ekstrak Carica papaya radix diduga mengandung senyawa alkaloid (Rf : 0,53), saponin (Rf : 0,93), flavonoid (Rf : 0,38 ; 0,75) dan tanin (Rf : 0,52 ; 0,88). Ekstrak Piper ornatum folium diduga mengandung senyawa saponin (Rf : 0,89), steroid (Rf :0,20 ; 0,42) dan tanin (Rf : 0,52 ; 0,71 ; 0,85). Ekstrak Nephelium lappaceum semen menunjukkan hasil positif terhadap keberadaan senyawa alkaloid (Rf : 0,65 ; 0,82), flavonoid (Rf : 0,83) dan tanin (Rf : 0,79 ; 0,92).
Upaya Peningkatan Produksi Perikanan Tangkap di PPP Dobo Kabupaten Kepulauan Aru Dalam Mendukung Maluku Sebagai Lumbung Ikan Nasional
Authors: Rumadan Galib , Ernaningsih Dwi , Telussa Riena F 
Published: February 2022

Pembangunan Provinsi Maluku sebagai Lumbung Ikan Nasional dengan estimasi target produksi 750.000 ton/tahun memberikan peran strategis pada Pelabuhan Perikanan Pantai Dobo Kabupaten Kepulauan Aru yang merupakan salah satu wilayah paling produktif dalam sektor perikanan tangkap. Namun, mengalami penurunan produksi dalam beberapa tahun terakhir. Penelitian ini bertujuan untuk menentukan, menganalisis dan menetapkan variabel prioritas dalam upaya meningkatkan produksi perikanan tangkap. Penelitian dilaksanakan pada bulan April hingga Agustus 2021 di PPP Dobo Kabupaten Kepulauan Aru Provinsi Maluku. Data primer dikumpulkan melalui survei dan wawancara kepada 5 orang pengelola pelabuhan dan 3 orang nelayan yang dipilih secara purposive sampling. Data yang dikumpulkan berupa faktor-faktor yang berpengaruh terhadap produksi perikanan tangkap yaitu kapal, alat tangkap, dan nelayan. Data selanjutnya dianalisis mengunakan Analytical Hierarchy Process. Hasil penelitian menunjukkan bahwa nilai kepentingan tertinggi pada pembinaan nelayan sehingga direkomendasikan sebagai alternatif yang tepat untuk neningkatkan produksi perikanan tangkap di PPP Dobo Kabupaten Kepulauan Aru.
MARKETING STRATEGY IMPLEMENTATION, SYSTEM MANAGERS ADAPT AND RESHAPE BUSINESS STRATEGY FOR PANDEMIC
Authors: Sulasih Sulasih , Adawiyah Wiwiek Rabiatul 
Published: February 2022

Contingency theory explains that the environment has a significant impact on an organization. Related to the current environmental conditions in which the whole world, including Indonesia, is experiencing a crisis due to the pandemic, entrepreneurs who can survive the uncertain economic conditions due to the pandemic outbreak are certainly entrepreneurs who can adapt to environmental changes just think smart, creative, and innovative. The research method used qualitative research approach with the survey method by generalizing the results of exploring in-depth data on SMEs in Banyumas. This study's purpose based on previous research's advice was to explore the use of technology in SMEs to ensure business continuity during the pandemic and to determine strategies for SME problems in Indonesia during the pandemic based on previous research results. Entrepreneurs are advisedly managed intelligently by determining a strategy related to marketing strategies and the business management system adapted to the changing environment to increase sales. Entrepreneurs should change conventional marketing systems and modernize by utilizing technology to run business activities. Several strategies for entrepreneurs to survive this pandemic situation can utilize digital technology and improve products, services, and CRM. Notably, management must be able to adapt by making several policies to control the business.