bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of a Nutrition Program for Weight Loss during the Pre-competition Period on the Body Composition, Hydration, and Mood Profile of Elite Greco–Roman Wrestlers
Authors: Ayar Muttalip , Yetgin Meral Kucuk , Agopyan Ani , Elmacioglu Funda 
Published: August 2022

Abstract

Objective The study aimed to investigate the effect of a nutrition program introduced among elite Greco–Roman wrestlers during weight loss period prior to the competition on the athletes’ body composition, hydration, and mood. Methods The experimental group comprised from the Greco–Roman Wrestling National Team (U23) of different weights (n = 8) and the control group consisted of substitute athletes (n = 8) with the same weights with the experimental group. To achieve the target weight, the experimental group followed a personalized weight loss program under the supervision of a dietitian, whereas the control group lost weight using their own methods. The athletes completed a mood profile questionnaire, food and fluid consumption, urine density evaluation, anthropometric measurements, and body composition assessments were performed. Results The athletes who followed a balanced diet under the guidance of a dietician had decreased body mass index, body weight, body fat rates (%) and urine density compared to the athletes who used traditional methods (P< 0.05). Negative changes in the control group and positive changes in the experimental group were observed in the mood profile scores (P< 0.05). There was a higher decrease in variables, including energy (kcal), carbohydrate (g/kg), protein (g/kg), fat (g/kg) and micronutrient consumption, in the control group (P< 0.05).Conclusion Change in nutritional intake at the macro and micro level was found to be more balanced among male athletes who followed a regular and planned nutrition program under a dietitian’s supervision. In addition, the experimental group had decreased body fat percentages and urine density, and underwent a positive change as confirmed by their mood profile.
Spatiotemporal Patterns and Environmental Drivers of Eastern Redcedar (Juniperus virginiana) Abundance along the Missouri River, USA
Authors: Illeperuma Nadeesha D. , Withanage Miyuraj Harishchandra Hikkaduwa , Magnuson Kimberly I. , Elliott Caroline M. , Vogelmann James E. , Dixon Mark D. 
Published: August 2022

Abstract
The authors have requested that this preprint be removed from Research Square.
Bifidobacterium longum upregulates mitochondrial activity and suppresses Parkinson’s disease in Caenorhabditis elegans
Authors: Sugawara Takaya , Sakamoto Kazuichi 
Published: August 2022

AbstractBifidobacterium is a probiotic bacterium that has positive effects on human health, including the regulation of intestinal function. This study aimed to identify novel bioactive effects of Bifidobacterium inCaenorhabditis elegans. Previously, we found thatBifidobacterium longumsignificantly increased the motility of nematodes and, although antioxidant effects are thought to be one of the factors, we hypothesized thatB. longummight have affected the muscles and mitochondria, causing an increase in motility. Thus, the purpose of this study was to analyze the bioactive effects and mechanisms of action ofB. longumon the muscle and mitochondria ofC. elegans. The results showed thatB. longumincreased the muscle mass, mitochondrial mass, ATP content, mitochondrial membrane potential, and mitochondrial ROS. Furthermore, high-resolution microscopy and qPCR showed thatB. longummaintained mitochondrial homeostasis. We also used inhibitors of the mitochondrial complexes to analyze those which were specifically targeted byB. longum. The results implicated mitochondrial complex I, which is closely associated with Parkinson’s disease. Furthermore,B. longumincreased the expression of dopaminergic neurons and decreased the expression of α-synuclein inC. elegans. Overall, we showed thatB. longumis beneficial to health and has the potential to prevent Parkinson’s disease.
Buccal mucosal membrane graft for correction of cicatricial lower eyelid retraction
Authors: Rafizadeh Seyed Mohsen , Daryabari Seyed-Hashem , Hassanpour Seyed Rahim , Nikdel Mojgan , Ghadimi Hadi 
Published: August 2022

Abstract

Purpose: To evaluate the outcomes of a surgical technique using buccal mucosal membrane graft for correction of cicatricial lower eyelid retraction.Methods: Twelve patients with unilateral cicatricial lower eyelid retraction were enrolled in the study. All patients underwent a four-step surgical technique consisted of release of scars, midface lift, transfer of buccal mucosal membrane to posterior lamella as spacer graft, and canthal tightening. All patients were followed for at least 12 months. Results: Mean preoperative Margin- -Reflex-Distance 2 (MRD2) was 7.73 ± 1.10 mm, compared to mean postoperative MRD2 of 5.04 ± 0.49 mm (P < 0.0001). The mean improvement in retraction was 2.69 mm. Postoperative scleral show was present in only one case and no major complications were observed. Conclusion: The four-step procedure (scar release, midface lift, buccal mucosal graft and canthal tightening) was an effective procedure to correct cicatricial lower eyelid retractions with acceptable outcomes and a low morbidity rate.
Clinical features and risk factors for interstitial lung disease spreading in low-dose irradiated areas after definitive radiotherapy with or without durvalumab consolidation therapy for patients with non-small cell lung cancer
Authors: Sakagami Mai , Inokuchi Haruo , Mukumoto Nobutaka , Itoyama Hiroshige , Hamaura Nobunari , Yamagishi Mutsumi , Mukumoto Naoki , Matsuda Shogo , Shibuya Keiko 
Published: August 2022

Abstract
Background: The current standard of care for patients with unresectable locally advanced non-small cell lung cancer (NSCLC) is chemoradiotherapy (CRT) combined with durvalumab consolidation therapy. However, radiotherapy (RT) always carries the risk of radiation pneumonitis (RP), which can preclude durvalumab continuation. In particular, the spread of interstitial lung disease (ILD) in low-dose areas or extending beyond the RT field often makes it difficult to determine the safety of continuation or rechallenging of durvalumab. Thus, we retrospectively analyzed ILD/RP after definitive RT with and without durvalumab, with assessment of radiologic features and dose distribution in RT.Methods: We retrospectively evaluated the clinical records, CT imaging, and radiotherapy planning data of 74 patients with NSCLC who underwent definitive RT at our institution between July 2016 and July 2020. Univariate analysis and propensity score analysis were performed to assess the risk factors for recurrence within one year and occurrence of ILD/RP.Results: In 68 patients followed up for more than one year, propensity score analysis showed that ≥7 cycles of durvalumab significantly reduced the risk of recurrence within one year (odds ratio: 0.232). Nineteen patients (26%) were diagnosed with ≥ Grade 2 and 7 (9.5%) with ≥ Grade 3 ILD/RP after completing RT. Propensity score analysis showed no significant correlation between durvalumab administration and ≥ Grade 2 ILD/RP. Twelve patients (16%) developed ILD/RP that spread outside the high-dose (>40 Gy) area, of whom 8 (67%) had ≥ Grade 2 and 3 (25%) had Grade 3 symptoms. Univariate analysis showed that high HbA1c level (>6.2%) was significantly associated with the ILD/RP distribution pattern. In propensity score analysis adjusted for risk factors for diabetes mellitus, high HbA1c level was also significantly correlated with ILD/RP pattern spreading outside the high-dose area (odds ratio: 9.865).Conclusions: Durvalumab improves 1-year progression-free survival without increasing the risk of ILD/RP. High HbA1c level was associated with ILD/RP distribution pattern spreading in the lower dose area or outside RT fields, with a high rate of symptoms. Further study of the clinical background of patients including diabetes is needed to safely increase the number of durvalumab doses after CRT.
Vaccine Effectiveness of Modified Vaccinia Ankara in Human Monkeypox
Authors: Arbel Ronen , Sagy Yael Wolff , Zucker Roy , Arieh Noa Gur , Markovits Hila , Abu-Ahmad Wiessam , Battat Erez , Ramot Noga , Carmeli Guy , Mark-Amir Avner , Wagner-Kolasko Gal , Duskin-Bitan Hadar , Yaron Shlomit , Peretz Alon , Hammerman Ariel , Lavie Gil , Netzer Doron 
Published: August 2022

Abstract
BackgroundThe recent global outbreak of the human monkeypox virus (MPXV) was declared a public health emergency by the World Health Organization. Modified Vaccinia Ankara (MVA) is currently the only FDA-approved vaccine against MPXV that was approved for this indication based on a study in non-human primates. Since there is currently scarce evidence of the efficacy in humans, our objective was to evaluate real-life vaccine effectiveness (VE) after providing one vaccine dose to individuals at risk of MPVX infection.MethodsThe study cohort included all Clalit Health Services (CHS) members estimated to be at moderate to high risk for MPXV infection. The study commenced on July 31, 2022, when the MVA vaccination campaign was initiated in CHS, and participants were followed until August 10, 2022. A Cox proportional-hazards regression model with time-dependent covariates was used to estimate the association between vaccination and MPXV infections with adjustment for sociodemographic and clinical risk factors.Results8,168 subjects met the study eligibility criteria (0.17% of CHS members). Of them, 626 (7.7%) were vaccinated with MVA and completed at least 7 days of follow-up. 14 infections were confirmed in CHS during the study period, all within the study cohort and all in unvaccinated participants. VE was estimated at 100% (95% CI: 100%-100%).ConclusionsThese short-term preliminary results suggest a very high VE of a single dose of MVA for MPVX infection in moderate to high-risk individuals. These findings suggest that urgent MVA vaccination of high-risk subjects may contribute to outbreak containment.
Fetal Effects of Mild Maternal COVID-19 Infection: Metabolomic profiling of cord blood
Authors: TURKOGLU Onur , ALHOUSSEINI Ali , SAJJA Sonia , IDLER Jay , STUART Sean , ASHRAFI Nadia , YILMAZ Ali , WHARTON Kurt , GRAHAM Stewart F. , BAHADO-SINGH Ray O. 
Published: August 2022

Abstract
Introduction: The impact of maternal coronavirus disease 2019 (COVID-19) infection on fetal health remains to be precisely characterized.Objectives: Using metabolomic profiling of newborn umbilical cord blood, we aimed to investigate the potential fetal biological consequences of maternal COVID-19 infection.Methods: Cord blood serum samples from 23 mild COVID-19 cases (mother infected/ newborn negative) and 23 gestational age-matched controls were analyzed using nuclear magnetic spectroscopy and liquid chromatography coupled with mass spectrometry. Metabolite set enrichment analysis (MSEA) was used to evaluate altered biochemical pathways due to COVID-19 intrauterine exposure. Logistic regression models were developed using metabolites to predict intrauterine exposure.Results: Significant concentration differences between groups (p-value <0.05) were observed in 19 metabolites. Elevated levels of glucocorticoids, pyruvate, lactate, purine metabolites, phenylalanine and branched chain amino acids of valine and isoleucine were discovered in cases while ceramide subclasses were decreased. The top metabolite model including cortisol and ceramide (d18:1/23:0) achieved an Area under the Receiver Operating Characteristics curve (95% CI) = 0.841 (0.725 - 0.957) for detecting fetal exposure to maternal COVID-19 infection. MSEA highlighted steroidogenesis, pyruvate metabolism, gluconeogenesis, and Warburg effect as the major perturbed metabolic pathways (p-value < 0.05). These changes indicate fetal increased oxidative metabolism, hyperinsulinemia, and inflammatory response. Conclusion: We present fetal biochemical changes related to intrauterine inflammation, altered energy metabolism in cases of mild maternal COVID-19 infection despite the absence of viral infection. Elucidation of the long-term consequences of these findings is imperative considering the large number of exposures in the population.
Data Mining Method in Seismology by Applying Cellular Automaton Equivalence of Ground Vibration Fluctuations Recorded Near the Epicenter of the 2011 Mw 9 East Japan Earthquake
Authors: Kikuchi Hiroyuki 
Published: August 2022

Abstract
This paper links ground vibration velocity fluctuation (GVF) recorded near an epicenter of the Great East Japan Earthquake of magnitude 9 (GEJE) with a cellular automaton (CA), and provides a data mining methodology using the CA to extract GEJE-related information from the GVF. Although the GVF can be discussed in the framework of the master equation which represents the thermodynamics of a stochastically fluctuating non-equilibrium system, the relation between the thermodynamic parameters and seismology-related phenomena is not clear. On the other hand, this relation can be relatively easily derived in CA. So, the thermodynamic equivalence between GVF and CA makes it possible to extract the seismology-related information from GVF by deriving the thermodynamic parameter associated with seismology-related information in CA. In the demonstrated example of data mining, the stress relaxation signal immediately after GEJE is discovered from the recorded GVF data by deriving the thermodynamic parameters representing the stress relaxation of CA and evaluating these thermodynamic parameters with respect to the recorded GVF data. Furthermore, the elastic rigidity and viscosity of the underground structures are estimated from the stress relaxation signal. The non-traditional features of this study are that the GVF of interest is a weak fluctuation signal with no specific waveform and that CA is not used to model ground motions.
Study on the factors influencing air valve protection against water hammer with column separation and rejoinder
Authors: Li Xiaozhou , Wang Tao , Zhang Yanhe , Guo Pengcheng 
Published: August 2022

Abstract
Air valves are used to suppress negative water pressures in water transmission pipelines. They also play a key role during the water filling and drainage stages in pipeline systems. However, systematic guidelines for the selection of air valve parameters are lacking. In practical engineering applications, the selection is mainly based on personal experience. If the selected parameters are not appropriate, negative pressures can occur in a pipeline due to insufficient air inflow or destructive water hammer pressures with column separation and rejoinder, which are caused by rapid air discharge. Given the subjectivity of the selection of air valve parameters in engineering applications, this paper introduces the structure and working principle of two different types of air valves. Combined with engineering examples, the one-dimensional transient flow elastic model and the characteristic method are used to conduct numerical simulations in MATLAB to investigate the influences of the air valve type, the inlet and outlet orifice diameters, and the inflow and outflow discharge coefficients on protection against water hammer with column separation and rejoinder. The inflow and outflow coefficients of the anti-slam air valve have a slight influence on preventing water hammers with column separation and rejoinder. The research results provide a theoretical basis for the rational selection of air valves in practical engineering applications.
A techno-economic assessment of nutrient recovery from wastewater using microalgae: scenario in India collected from published literature
Authors: Fathima Jesna , Chatterjee Pritha 
Published: August 2022

Abstract
The true potential of the microalgae-based wastewater treatment (MWT) process is determined based on whether the process will provide a positive energy output and whether it is economically viable. The objectives of this study are dynamic modelling of microalgae growth based on initial wastewater concentration, temperature, solar radiation and a techno-economic assessment for an MWT scheme for application in a hot, dry climate. Through reference to relevant literature data on MWT in the Indian subcontinent, a selection of appropriate microalgal species Chlorella and Scenedesmus was made. The dynamic model developed was successfully calibrated and validated using independent experimental data collected from the published literature. Cost of production of bio-crude from microalgae grown in a hybrid photobioreactor and pond system in kitchen wastewater of Indian Institute of Technology, Hyderabad was calculated. A break-even selling price (BESP) of US$0.549/kg was obtained for the microalgae biomass. The cost of production of 1 L bio-crude was US$0.96 (Rs 69–74), which is comparable with crude oil cost. The model developed can be used by practising engineers to predict biomass growth and nutrient removal, thereby achieving a break-even point for cost efficiency.
Assessment of the application of cladode cactus mucilage flocculants for hot chemical degreasing electroplating wastewater treatment and reuse: process efficiency and storage stability
Authors: Riahi Khalifa , Chaabane Safa , Werhenin Ammeri Rim , Jaballah Adel , Dörr Michael 
Published: August 2022

Abstract
Pressures related to urban growth and industrial activities exacerbated by climate change had an impact on water resources in Tunisia. The present study examines the application of cladode cactus mucilage (CCM) flocculants for hot alkaline chemical degreasing Zn-electroplating wastewater treatment and reuse (WWTR). The CCM flocculation process was selected through their environmental benefits, economic facilities, sustainable use of the natural biopolymer product, input biopolymers substitution, and on-site treated wastewater (TWW) reuse and recovery. The alum coagulation and CCM flocculation were performed by the jar test series. The suitability of treated wastewater quality (TWWQ) with alum/CCM was also assessed for reuse purpose in terms of corrosion-scaling indices (RSI, LSI, PSI, AI), oxidation-reduction potential (ORP), and microbiological community growth (Bacillus, Pseudomonas, Mesophilic bacteria and yeasts) for 28 days storage at 25 °C. The total alkalinity removal efficiency reached 95.8% with an optimum dosage of alum + CCM for hot alkaline chemical degreasing wastewater bath rinsing. The results showed that the stability of TWWQ has significantly deteriorated during storage leading to aggressive wastewater, pathogen growth, and biological malodor production which make them unsuitable for reuse. Therefore, there is a need for CCM processing alternatives that preserve the physico-chemical and microbial of TWW properties during storage.
Comparing the effects of Cu-Ti/RuO2-IrO2 electrode configuration on the electro-reduction of nitrate
Authors: Shemer Hilla , Semiat Raphael 
Published: August 2022

AbstractNitrate pollution is a global problem as it affects both the environment and human health. The objective of this research was to study the effect of electrode configuration on the electro-reduction of nitrate. Coaxial cylindrical (inner rod and outer tube copper cathodes) and vertical plate parallel copper cathodes paired with Ti/RuO2-IrO2 (rod, tube, and plate) configurations were studied under various current densities and initial nitrate concentrations. The efficiency of each configuration was determined based on the removal efficiency of nitrate, specific energy consumption, mass transfer coefficients, and first order rate constants. Additionally, the overall systems’ resistance and geometric factors are discussed. It was found that the performances of the inner rod and outer tube copper cathodes were similar. The vertical plate parallel configuration was superior to the coaxial cylindrical electrode setup, as evident from a higher maximum nitrate removal of 74 and 56% at a current density of 7 mA/cm2 and lower energy consumption of 46.7 × 10−3 and 54.3 × 10−3 kWh/mmol NO3− at 36.4 mA/cm2, respectively. In addition, the mass transfer coefficients and first order rate constants were higher in all conditions tested for the vertical plate parallel configuration.
Towards a decentralized solution for sewer leakage detection – a review
Authors: Sadeghikhah Afshin , Ahmed Ehtesham , Krebs Peter 
Published: August 2022

AbstractSewer pipelines often leak due to physical, operational, and environmental deterioration factors. Due to the hidden infrastructure of the sewer systems, leakage detection is often costly, challenging, and crucial at the city scale. Various sewer inspection methods (SIMs) have been developed and implemented at this time. This study evaluates the existing SIMs and categorizes them based on their area of impact (AoI) into three classes. Tier-one (T-I) methods, such as deterioration models and hotspot mapping, tend to grasp a broader and reliable understanding of the sewer systems' structural health and pinpoint the network sections that are more prone to leakage. As an intermediate solution, Tier-two (T-II) non-destructive methods, such as aerial thermal imagery (ATI) and electrical resistivity tomography (ERT), inspect the potential pipe clusters regardless of their material and visualize the leaked plume generated from defects and cracks. Tier-three (T-III) methods include in-pipe SIMs, such as visual and multi-sensory inspections, that can provide an in-depth understanding of the pipe and its deterioration stage. In this study, we suggest that a sustainable sewer inspection plan should include at least two SIMs belonging to different tiers to provide a dual investigation of precision and AoI, a balance between cost and time as well as an equilibrium between self-sufficiency and decentralization.
Research Progress in Elucidating the Mechanisms Underlying Resveratrol
Action on Lung Cancer
Authors: Li Chun-Guang , Ma Yu-Shui , Fu Da , Xin Rui , Shen Biao , Huang Zhong-Yan , Liu Ji-Bin , Li Sha , Jiang Geng-Xi , Zhang Jie , Cao Ya-Hong , Zou Da-Zhi , Li Wen 
Published: August 2022

Abstract:
Resveratrol has several functions, including protection of the heart and nervous system
and exerts antidiabetic, anti-inflammatory, anti-aging, and antitumor effects. It is reported to impede
the occurrence and development of tumors in cancer cell lines, animal models, and clinical
studies. In vitro and in vivo experiments show that it exerts preventive or adjuvant therapeutic
effects in pancreatic, colorectal, prostate, liver, and lung cancers. Mechanistic research reports
show that resveratrol can induce tumor cell apoptosis and autophagy, inhibit cell cycle and angiogenesis,
regulate nuclear factors and cyclooxygenase signal transduction pathways, and inhibit
carcinogens' metabolic activation and alter tumor-related expression patterns; anti-oxidation affects
tumor cell proliferation, metastasis, and apoptosis. However, the exact mechanism underlying its
action remains unclear. This review highlights multiple aspects of the biological impacts and
mechanisms underlying resveratrol action on the occurrence and development of lung cancer.