bluuebunny/crossref_metadata_2025_split huggingface dataset:
MCTP1 promotes SNAI1-driven neuroendocrine differentiation and epithelial-to- mesenchymal transition of prostate cancer enhancement by ZBTB46/FOXA2/HIF1A
Authors: Liu Yen-Nien , Chen Wei-Yu , Yeh Hsiu-Lien , Chen Wei-Hao , Jiang Kuo-Ching , Li Han-Ru , Tram Van Thi Ngoc , Dung Phan Vu Thuy , Chen Zi-Qing , Hsiao Michael , Huang Jiaoti , Wen Yu-Ching 
Published: June 2022

Abstract
Background
Prostate cancer (PCa) patients with bone metastases frequently exhibit abnormal calcium homeostasis. However, the molecular mechanisms underlying bone metastasis mediated by activated calcium transport signaling remain unclear. Our results showed that androgen deprivation therapy (ADT) of PCa upregulates a calcium sensor transmembrane protein, the multiple C2 domains transmembrane protein 1 (MCTP1), which is upregulated by hypoxia-induced ZBTB46/FOXA2/HIF1A signaling and is associated with SNAI1-driven neuroendocrine (NE) differentiation (NED) and epithelial-to-mesenchymal transition (EMT) in PCa.
Methods
Hypoxia induced interactions between ZBTB46, HIF1A, and FOXA2 were confirmed by immunoprecipitation (IP)-Western Blot (WB). Correlation between MCTP1 and ZBTB46/FOXA2/HIF1A complexes was analyzed by immunohistochemical (IHC) staining in consecutive tissue sections of PCa tissue microarray (TMA) comprising primary PCa and small cell PCa (SCPC) samples. The regulatory network between MCTP1 and the hypoxia-induced ZBTB46/FOXA2/HIF1A axis was investigated by chromatin IP (ChIP)-Seq analysis, ChIP assay, and promoter reporter assays. The effect of MCTP1 on SNAI1 expression driving NED and EMT in PCa was identified in PCa cell lines using mimic hypoxia, ADT, or long-term androgen receptor (AR) antagonist culture systems. Activation of the MCTP1-mediated calcium-related pathway induces SNAI1-driven NED and aggressive progression of PCa under hypoxic conditions was examined by Fluo-8 AM staining combined with flow cytometry, migration, invasion, and xenograft model validation.
Results
MCTP1 is highly expressed in advanced PCa tissues and is associated with ZBTB46/FOXA2/HIF1A abundance. Upregulation of MCTP1 enhances SNAI1-mediated cell migration and EMT responses and is associated with hypoxia-driven NED in PCa after ADT. Mechanistically, hypoxia enhances the MCTP1-mediated calcium/AKT pathway to stabilize SNAI1 in PCa to promote EMT and NED by increasing the SNAI1-driven expression of EMT and NE markers. MCTP1 knockdown abrogated hypoxia-enhanced EMT and NED by reducing calcium/AKT pathway-driven SNAI1 expression.
Conclusions
Our study shows the molecular mechanism by which hypoxia-associated ZBTB46/FOXA2/HIF1A transcription factor interaction upregulates the calcium sensor transmembrane protein MCTP1 in ADT-resistant PCa, and explores how MCTP1 promotes NED and EMT in PCa by upregulating SNAI1-driven EMT and NE markers.
Original research article: An advanced bipolar device helps reduce the rate of postoperative pancreatic fistula in laparoscopic gastrectomy for gastric cancer patients: A propensity score-matched analysis
Authors: Shibao Kazunori , Honda Shinsaku , Adachi Yasuhiro , Kohi Shiro , Kudou Yuzan , Matayoshi Nobutaka , Sato Nagahiro , Hirata Keiji 
Published: June 2022

Abstract
Background: Advanced bipolar devices (ABD; e.g. LigaSureTM) have a lower blade temperature than ultrasonically activated devices (USAD; e.g. Harmonic® and SonicisionTM) during activation, potentially enabling accurate lymph node dissection with less risk of postoperative pancreatic fistula (POPF) due to pancreatic thermal injury in laparoscopic gastrectomy. Therefore, this study aimed to compared the efficacy and safety of ABD and USAD in laparosopic gastrectomy for gastric cancer patients.Methods: A retrospective cohort study was conducted in patients who underwent laparoscopic distal gastrectomy (LDG) between August 2008 and September 2020. A total of 371 patients were enrolled, and short-term surgical outcomes, including grade ≥II POPF, were compared between an ABD and a USAD. The risk factors for POPF in LDG were investigated by univariate and multivariate analyses.Results: A propensity score-matching algorithm was used to select 120 patients for each group. The POPF rate was significantly lower (0.8% vs. 9.2%, p < 0.001), the morbidity rate was lower (13.3% vs. 28.3%, p<0.001), the length of hospitalization was shorter (14 vs. 19 days, P < 0.001), and the lymph node retrieval rate was higher (34 vs. 26, P < 0.001) with an ABD than with a USAD. There were no mortalities in either group. A multivariate analysis showed that USAD was the only independent risk factor with a considerably high OR for the occurrence of POPF (USAD/ABD, OR 8.38, P = 0.0466).Conclusion: ABD may contribute to improving the safety of laparoscopic gastrectomy for gastric cancer patients.
Systematic description of COVID -19 pandemic using exact SIR solutions and
Gumbel distributions
Authors: Amaro Jose Enrique 
Published: June 2022

Abstract
An epidemiological study of deaths is carried out in a dozen countries by analyzing the first wave of the COVID-19 pandemic. These countries are among those most affected by the first wave, i.e. where daily-death data series may closely resemble a solution of the basic SIR equations. The SIR equations are solved parametrically using the proper time as parameter. Some general properties of the SIR solutions are studied such as time-scaling and asymmetry. Additionally, we use approximations to the SIR solutions through Gumbel functions, which present a very similar behavior. The parameters of the SIR model and the Gumbel function are extracted from the data and compared for the different countries. It is found that ten of the selected countries are very well described by the solutions of the SIR model, with a basic reproduction number between 3 and 8.
A proposal to reduce false alarms in anomaly detection systems with counterfactuals generated through multi-objective constrained optimization
Authors: Monteiro Wellington Rodrigo , Reynoso-Meza Gilberto 
Published: June 2022

Abstract

Anomaly detection systems are a field of study responsible for implementing techniques capable of detecting abnormal changes in time series. These abnormal changes have a particular usage in industrial applications such as water monitoring and manufacturing. One of the challenges in these systems is to reduce the number of false-positives: it is not desired to trigger false alarms to the users frequently. In order to solve this challenge, we propose a strategy using a counterfactual generation algorithm to be applied as a post-processing method on a previously trained, standard anomaly detection anomaly. This counterfactual generation algorithm is modeled as a multi-objective optimization constrained problem. These counterfactuals are then evaluated by a classifier trained to find members of false-positives. Results show that this proposal can successfully reduce the number of false-positives.
Evaluation of Therapy in Traumatic Elderly Falls to Return Autonomy and Functional Status
Authors: Foote MD Christopher W , Vanier Cheryl , Chen  , Palacio  
Published: June 2022

Abstract
Background: Traumatic falls among the elderly (≥65 years old) as the leading cause of injury, morbidity and mortality are increasing with rising medical costs.Methods: Retrospective chart review of elderly mechanical fall patients (288 patients) admitted to an American College of Surgeons level II trauma center from January 2016-January 2021. Demographics, comorbidities, and analysis of physical/occupational therapies of admissions to assess predictive variables for subsequent fall readmissions.Results: Out of 288 patients, 243 received therapy with 45 readmissions for subsequent falls. Age (p= 0.016), BMI (p= 0.035), previous falls (p= 0.003), walker/cane use (p= 0.039), and dementia (p= 0.038) were predictive of readmission. Therapy was shown to benefit patients but deferred therapy sessions were shown to be associated with prolonged hospitalization.Conclusions: Directed therapy may improve functionality and return autonomy to elderly mechanical fall patients admitted to trauma services.
Respiratory depression following cesarean section with single-shot spinal with 100 μg morphine: a prospective observational study
Authors: Ida Mitsuru , Onodera Hiroki , Naito Yusuke , Kinomoto Akane , Kawaguchi Masahiko 
Published: June 2022

Abstract
Background
Little evidence is available regarding bradypnea measured using continuous monitoring following cesarean section. We aimed to evaluate the rate of cumulative bradypnea time (total bradypnea time/total monitoring time) and its related factors in these parturients.
Methods
This prospective observational study included women undergoing cesarean section under single-shot spinal including 0.1 mg morphine. The Berlin Questionnaire was used to screen for sleep apnea syndrome preoperatively. Respiratory rate and oxygen saturation (SpO2) were monitored continuously using an adhesive acoustic respiration sensor and pulse oximeter, respectively, at least 6 hours after cesarean section. Bradypnea was defined as a respiratory rate < 8 bpm lasting at least 25 s (sustained bradypnea) and at least 15 s (immediate bradypnea), respectively. Hypoxemia was defined as SpO2 < 92% lasting at least 25 s (sustained hypoxemia) and at least 15 s (immediate hypoxemia) multiple regression analysis was applied to assess related factors to the rate of cumulative sustained bradypnea.
Results
Of 159 patients, the Berlin Questionnaire was positive in 16.3%, and 77 (48.4%) experienced sustained bradypnea. The median rate of cumulative sustained bradypnea time was 0.70% (interquartile range 0.35 to 1.45) without any related factors. The incidence of immediate bradypnea and sustained and immediate hypoxemia were 58.5%, 24.5%, and 37.7%, respectively. However, none of the factors were statistically significant.
Conclusion
After cesarean section performed with intrathecal morphine 0.1 mg, respiratory depression events were commonly observed. However, the rate of cumulative bradypnea time was very low and there were no related factors.
Trends in Inequality in Maternal and Child Health and Health Care in Uganda: analysis of the Uganda Demographic and Health Surveys
Authors: Kakama Alex Ayebazibwe , Basaza Robert 
Published: June 2022

Abstract
Background: Uganda has made great strides in improving maternal and child health. However, little is known about how this improvement has been distributed across different socioeconomic categories, and how the health inequalities have changed over time. This study analyses data from Demographic and Health Surveys (DHS) conducted in 2006, 2011, and 2016 in Uganda, to assess trends in inequality for a variety of mother and child health and health care indicators. Methods: The indicators studied are acknowledged as critical for monitoring and evaluating maternal and child health status. These include infant and child mortality, underweight status, stunting, and prevalence of diarrhea. Antenatal care, skilled birth attendance, delivery in health facilities, contraception prevalence, full immunization coverage, and medical treatment for child diarrhea and Acute Respiratory tract infections (ARI) are all health care indicators. Two metrics of inequity were used: the quintile ratio, which evaluates discrepancies between the wealthiest and poorest quintiles, and the concentration index, which utilizes data from all five quintiles. Results: The study found extraordinary, universal improvement in population averages in most of the indices, ranging from the poorest to the wealthiest groups, between rural and urban areas. However, significant socioeconomic and rural-urban disparities persist. Under-five mortality, malnutrition in children (Stunting and Underweight), the prevalence of anaemia, mothers with low Body Mass Index (BMI), and the prevalence of ARI were found to have worsening inequities.Healthcare utilization measures such as skilled birth attendants, facility delivery, contraceptive prevalence rate, child immunization, and Insecticide Treated Mosquito Net (ITN) usage were found to be significantly lowering disparity levels towards a perfect equity stance. Three healthcare utilization indicators, namely medical treatment for diarrhea, medical treatment for ARI, and medical treatment for fever, demonstrated a perfect equitable situation.Conclusion: Increased use of health services among the poor and rural populations leads to improved health status and, as a result, the elimination of disparities between the poor and the wealthy, rural and urban people.Recommendation: Intervention initiatives should prioritize the impoverished and rural communities while also considering the wealthier and urban groups.
Resiliência: uma competência da Enfermagem
Authors: Cunha Isabel Cristina Kowal Olm 
Published: June 2022

Certamente para todos, este ano de 2020 está sendo um dos mais difíceis de nossas vidas. Reagirmos para sobreviver ao novo normal tem sido um desafio diário, em todas as áreas de atuação.É, contudo, no contexto de desafios que desenvolvemos novas competências e adquirimos forças para continuar e reagir. Muitas pessoas absorvem os problemas, tragédias e dificuldades com mais facilidade do que outras e conseguem em pouco tempo “dar a volta por cima”, não se deixando abater. Os neurocientistas chamam esta característica de resiliência.O dicionário nos ensina que resiliência é, na física, a propriedade dos corpos de voltarem à sua forma original depois de terem sofrido deformação ou choque1. O termo tem sido usado para caracterizar a capacidade que se tem de se adaptar às intempéries, às alterações ou aos infortúnios. Pode-se dizer de forma simplista que é tendência natural que algumas pessoas tem para se recuperar ou superar com facilidade os problemas que aparecem2,3.Existem estudos que mostram diferentes abordagens da resiliência dos profissionais de enfermagem, com e sem a aplicação de questionários4,5. Resultados permitem entender porque mesmo depois de imensas dificuldades como condições adversas de trabalho tanto na jornada excessiva como na falta de materiais e equipamentos, o lidar com a morte constantemente e com o medo de contaminar-se, a Enfermagem volta e continua seu trabalho, mesmo à beira da exaustão. Todavia todos alertam para os efeitos perversos das dificuldades e adversidades constantes e em longos períodos para o burnout, e a queda na saúde mental, apesar da resiliência. Ou seja, resiliência tem limite!Nesta pandemia de Covid-19, ao acompanharmos as imensas dificuldades e desafios pelas quais passam os enfermeiros, técnicos e auxiliares de enfermagem, e mesmo assim, conseguido se superar, dar o melhor de si na linha de frente e sendo responsáveis diretos pela assistência à beira do leito, feita muitas vezes de forma apaixonada, com inovação e superação, podemos afirmar que uma das competências mais desenvolvidas está sendo a resiliência. Todavia, a catástrofe mundial que estamos atravessando, pela sua extensão não somente em todos os países, mas em diferentes segmentos da população, pela sua alta capacidade de infecção, letalidade e sequelas, exige dos profissionais, muito mais do que resiliência.É urgente que estes sejam respeitados, com adequadas condições e jornadas de trabalho, proteção com equipamentos seguros e remuneração condizente com as responsabilidades assumidas na pandemia. Reconhecimento e homenagens com músicas, lives, poesias, é bom, aquecem o coração, mas o que se quer é valorização destes profissionais antes, durante e após esta pandemia, para que com a resiliência que já tem, possam continuar atuando como os verdadeiros heróis do cuidado.
Utility of Indian Fruits in Cancer Prevention and Treatment: Time to Undertake Translational and Bedside Studies
Authors: Prabhakar Pankaj , Pavankumar Giriyapura Srikantachar , Raghu Shamprasad Varija , Rao Suresh , Prasad Krishna , George Thomas , Baliga Manjeshwar Shrinath 
Published: June 2022

Abstract:The World Health Organization predicts a 70% increase in cancer incidents in developing nations over the next decade, and it will be the second leading cause of death worldwide. Traditional plant-based medicine systems play an important role against various diseases and provide health care to a large section of the population in developing countries. Indigenous fruits and their bioactive compounds with beneficial effects like antioxidant, antiproliferative, and immunomodulatory are shown to be useful in preventing the incidence of cancer. India is one of the biodiversity regions and is native to numerous flora and fauna in the world. Of the many fruiting trees indigenous to India, Mango (Mangifera indica), Black plum (Eugenia jambolana or Syzygium jambolana), Indian gooseberry (Emblica officinalis or Phyllanthus emblica), kokum (Garcinia indica or Brindonia indica), stone apple or bael (Aegle marmelos), Jackfruit (Artocarpus heterophyllus), Karaunda (Carissa carandas) and Phalsa (Grewia asiatica), Monkey Jackfruit (Artocarpus lakoocha) and Elephant apple (Dillenia indica) have been shown to be beneficial in preventing cancer and in the treatment of cancer in validated preclinical models of study. In this review, efforts are also made to collate the fruits' anticancer effects and the important phytochemicals. Efforts are also made to address the underlying mechanism/s responsible for the beneficial effects of these fruits in cancer prevention and treatment. These fruits have been a part of the diet, are non-toxic, and easily acceptable for human application. The plants and some of their phytochemicals possess diverse medicinal properties. The authors propose that future studies should be directed at detailed studies with various preclinical models of study with both composite fruit extract/juice and the individual phytochemicals. Additionally, translational studies should be planned with the highly beneficial, well-investigated and pharmacologically multifactorial amla to understand its usefulness as a cancer preventive in the high-risk population and as a supportive agent in cancer survivors. The outcome of both preclinical and clinical studies will be useful for patients, the healthcare fraternity, pharmaceutical, and agro-based sectors.
An Intervention to Connect Patients With Psychosis and Volunteers via Smartphone (the Phone Pal): Development Study
Authors: Pinto da Costa Mariana ,   Phone Pal Advisory Groups
Published: June 2022

Background
Intervention development is a critical stage. However, evidence indicates that the substandard reporting of intervention details is widespread.

Objective
This study aimed to provide an overview of the guiding frameworks, methodology, and stages for the design and construction of a new complex intervention—the Phone Pal.

Methods
The intervention development process followed the Medical Research Council framework for developing complex interventions as well as the person-based approach. The intervention was developed following the evidence synthesis of a literature review, a focus group study, and a survey after consultation and input from advisory groups with a range of stakeholders, including patients, volunteers, clinicians, and academics.

Results
The developed logic model outlines the contextual factors, intervention, mechanisms of change, and short- and long-term outcomes. The operationalized intervention required matching 1 patient with 1 volunteer to communicate with each other through a smartphone via SMS text messages, WhatsApp messages or email, and audio or video calls. Each participant was encouraged to communicate with their match at least once per week for a 12-week period using informal conversation.

Conclusions
The systematic process and theoretically sound strategy through which this intervention was developed can provide insights to future researchers on the reality of developing and preparing the operationalization of a digital intervention using multiple components.
Restoring rotational stability following anterior cruciate ligament surgery: single-bundle reconstruction combined with lateral extra-articular tenodesis versus double-bundle reconstruction
Authors: Legnani Claudio , Borgo Enrico , Macchi Vittorio , Ventura Alberto 
Published: June 2022

Aim:
To compare the outcomes of patients who underwent single-bundle (SB) anterior cruciate ligament (ACL) reconstruction combined with lateral extra-articular tenodesis (LET) with the outcomes of those who underwent double-bundle (DB) ACL reconstruction.
Methods:
16 patients who underwent ACL hamstring SB reconstruction combined with LET (Coker–Arnold modification of the MacIntosh procedure) were retrospectively compared with 20 patients who underwent hamstring DB reconstruction at an average follow-up of 6.2 years. Assessment included Lysholm and International Knee Documentation Committee scores, objective examination and instrumented laxity test.
Results:
No complications were reported. Mean Lysholm and International Knee Documentation Committee scores significantly increased from preoperatively (p < 0.05). No differences were reported between the two groups with regard to point scales, anterior tibial translation and pivot-shift test (p = not significant).
Conclusions:
Both DB ACL reconstruction and combined LET and autologous hamstring SB ACL reconstruction are effective at providing satisfying functional outcomes and restoring rotational stability.
In silico Target Class Prediction and Probabilities for Plant Derived Omega 3 Fatty Acid from Ethyl Acetate Fraction of Moringa oleifera Leaf Extract
Authors: Murugan M. , Krishnaveni K. , Sabitha M. , Kandeepan C. , Senthilkumar N. , Loganathan T. , Grace Lydial Pushpalatha G. Lydial , Pandiarajan G. , Ramya S. , Jayakumararaj R. 
Published: June 2022

Plant Derived Omega 3 Fatty Acid – α Linolenic Acid (ALA) a carboxylic acid with 18 carbon atoms, 3 cis double bonds. ALA obtained from plant based food source is converted into eicosa-pentaenoic acid (EPA) and docosa-hexaenoic acid (DHA). However, the rate of conversion is influenced by dose, gender, and health status. Further, intake of ALA significantly reduces the risk of sudden death among myocardial infarction patients consistent with induced antiarrhythmic effect. ALA is concomitant with cardiovascular-protective, anti-cancer, neuro-protective, anti-osteoporotic, anti-inflammatory, and anti-oxidative properties. ALA has anti-metabolic syndrome that regulates gut-micro-floral functionalities. Clinical trials indicate that ALA can be used in the management of multi-metabolic syndrome effects but in-depth target based ADMET studies are required to ascertain its clinical efficacy and market potential.
Keywords: ADMET; Moringa oleifera; Secondary Metabolites; Natural Products (NPs); Bioactive Substances; Octadecatrienoic acid (ODA); Eicosa-Pentaenoic Acid (EPA); Docosa-Hexaenoic Acid (DHA); Plant Derived Omega 3 Fatty Acid (PDO3FA)
Analysis of poverty factors in Sulawesi by using path analysis
Authors: Fadjryani Fadjryani , Lombang Nur Sakinah 
Published: June 2022

Poverty is a human inability to meet the needs of life. Factors that affect poverty can be seen from various indicators. In this study, the path analysis method was used to analyze the factors that directly and indirectly influence poverty in Sulawesi. The results showed that the number of poor people, the labor force participation rate, the human development index, and the average length of schooling had a direct effect on the poverty depth index. Then, the human development index, the average length of schooling, and the poverty depth index have a direct effect on the poverty level. Then, the human development index and the average length of schooling also indirectly affect the poverty level through the poverty depth index.
Keywords: Path Analysis, Poverty Level