bluuebunny/crossref_metadata_2025_split huggingface dataset:
Credibility and Generalization of the Minimally Important Difference Concept in Dermatology
Authors: Speeckaert Reinhart , Belpaire Arno , Herbelet Sandrine , Lambert Jo , van Geel Nanja 
Published: August 2022

ImportanceThe minimally important difference (MID) represents the point at which a difference in an outcome measure (eg, Dermatology Life Quality Index) is important enough that it warrants a change in treatment, and, to the authors’ knowledge, the robustness and limitations of MIDs have not been thoroughly evaluated in skin diseases. The MID is increasingly used in clinical trials to demonstrate that an intervention is worthwhile for patients; furthermore, MIDs also contribute to sample size calculations in clinical trials, influence treatment guidelines, and can guide clinicians to modify treatment.ObjectiveTo evaluate the credibility and generalization of MIDs for patient-reported outcome measures (PROMs) in skin disorders.Evidence ReviewA systematic search was conducted in PubMed and Embase for all original articles using the MID concept for skin disorders from inception to December 29, 2021. The credibility of MIDs obtained via an anchor-based approach (eg, global rating of change scale) was assessed with a previously developed credibility instrument. The validity of generalizing established MIDs to other patient groups was evaluated based on the diagnosis and the patient characteristics.FindingsA total of 126 articles were selected, and 84 different MIDs were identified for PROMs. A total of 13 of 84 MIDs (15.5%) for PROMs displayed acceptable credibility. The anchors used had varying capacity to assess minimal important changes from a patient’s perspective and were deemed inappropriate for this purpose in 52 of 84 cases (61.9%). Correlations between the anchors and PROMs were frequently not determined (39 of 84; 46.4%). The time interval for anchor questions assessing a change in the experienced disease burden was not optimal for 10 of 32 transition anchors (&amp;gt;3 months), introducing potential recall bias. Previously reported MIDs were widely used to examine relevant changes in other study populations. However, the diagnosis and disease severity were different from the original MID population in 39 of 70 (55.7%) and 45 of 70 (64.3%) cases, respectively.Conclusions and RelevanceIn this scoping review, only a minority of MIDs for PROMs demonstrated sufficient credibility in dermatology. Inappropriate generalization of previously reported MIDs to patient populations with different disease characteristics was found to be a major concern. Furthermore, the study supported the use of multiple anchors and encouraged consistent reporting of the correlation between changes in the anchor and changes in the outcome measures.
Maternal Mental Health and Infant Development During the COVID-19 Pandemic
Authors: Firestein Morgan R. , Dumitriu Dani , Marsh Rachel , Monk Catherine 
Published: August 2022

ImportanceThe COVID-19 pandemic has prompted an unprecedented need to rapidly investigate the potential consequences for maternal mental health, infant and child development, and the mother-infant relationship.ObservationsGlobally, the mental health of pregnant and postpartum individuals has worsened during the pandemic regardless of infection status, and these concerning changes have disproportionally affected racial and ethnic minoritized people from underserved populations. Early indicators of infant neurobehavioral outcomes suggest that while in utero exposure to a maternal SARS-CoV-2 infection is likely negligible, limited data are available regarding the neurodevelopmental consequences for the generation of infants born during the pandemic. High maternal depression and grief during the COVID-19 pandemic are associated with lower levels of self-reported maternal-infant bonding. Yet nearly all published reports of child neurodevelopmental outcomes and dyadic functioning in the context of the pandemic rely on self-reported and parent-reported measures, which are subject to bias.Conclusions and RelevanceIn the context of prior research, and considering the paucity of research on infant neurodevelopment following prenatal SARS-CoV-2 exposure and birth during the pandemic, robust scientific investigation is needed to detect indicators of compromised early outcomes that could inform widespread assessment and accessible intervention. We simultaneously caution against reflexive apprehension regarding the generation of children born during the COVID-19 pandemic.
Robust adaptive dynamic surface control scheme for a class of single‐input and single‐output uncertain nonlinear systems in strict‐feedback form
Authors: Soukkou Yassine , Tadjine Mohamed , Nibouche Mokhtar , Zhu Quanmin 
Published: August 2022

SummaryThis article presents a robust adaptive dynamic surface control using σ‐modification adaptation laws for a class of single‐input and single‐output (SISO) uncertain nonlinear systems in strict‐feedback form with parametric uncertainties and external disturbances. The proposed scheme is developed by employing dynamic surface control based robust adaptive control technique. The key features of the approach are that, first, the problem of explosion of complexity inherent in the conventional adaptive backstepping control method is avoided, second, the proposed approach of σ‐modification adaptation laws gives fast and accurate parameter estimation performance, and, third, the closed‐loop signals of the system are proven to be uniformly ultimately bounded (UUB) by using the Lyapunov stability theory. We show the effectiveness of our approach by simulating an electromechanical system.
Colossal Room‐Temperature Terahertz Topological Response in Type‐II Weyl Semimetal NbIrTe4
Authors: Zhang Jiantian , Zhang Tianning , Yan Luo , Zhu Chao , Shen Wanfu , Hu Chunguang , Lei Hongxiang , Luo Heng , Zhang Daohua , Liu Fucai , Liu Zheng , Tong Jinchao , Zhou Liujiang , Yu Peng , Yang Guowei 
Published: August 2022

AbstractThe electromagnetic spectrum between microwave and infrared light is termed the “terahertz (THz) gap,” of which there is an urgent lack of feasible and efficient room‐temperature (RT) THz detectors. Type‐II Weyl semimetals (WSMs) have been predicted to host significant RT topological photoresponses in low‐frequency regions, especially in the THz gap, well addressing the shortcomings of THz detectors. However, such devices have not been experimentally realized yet. Herein, a type‐II WSM (NbIrTe4) is selected to fabricate THz detector, which exhibits a photoresponsivity of 5.7 × 104 V W−1 and a one‐year air stability at RT. Such excellent THz‐detection performance can be attributed to the topological effect of type‐II WSM in which the effective mass of photogenerated electrons can be reduced by the large tilting angle of Weyl nodes to further improve mobility and photoresponsivity. Impressively, this device shows a giant intrinsic anisotropic conductance (σmax/σmin = 339) and THz response (Iph‐max/Iph‐min = 40.9), both of which are record values known. The findings open a new avenue for the realization of uncooled and highly sensitive THz detectors by exploring type‐II WSM‐based devices.
Dam impoundment elevates soil phosphorus and some trace elements in reservoir hydro‐fluctuation belts
Authors: Yang Dan , Xie Zongqiang 
Published: August 2022

AbstractTo examine the role of dam impoundment in elevating the levels of soil‐associated phosphorus (P) and trace elements in reservoir hydro‐fluctuation belts (RHB), soil samples in RHB and adjacent uplands (non‐flooded area, NFA) in the Three Gorges Reservoir, China, were collected and analyzed. Concentrations of available P, copper (Cu), chromium (Cr), and zinc (Zn) were found to be higher in RHB than in NFA (p < .05), whereas organic carbon was comparable in RHB and NFA (p > .05). The elevated levels of Cu, Cr, and Zn in RHB were probably associated the repeated drying–rewetting cycles created by the dam impoundment. The 95th percentile of the single‐factor pollution index and geo‐accumulation index in RHB were 1.29 and −0.21 for Zn, 3.21 and 1.15 for Cu and 3.37 and 1.17 for Cr. Elevated pollution potential of soil‐associated Zn, Cu, and Cr existed in RHB of the Three Gorges Reservoir.Core Ideas

Dam impoundments decreased total C and total N concentrations in reservoir flooded soils.
Cu, Zn, and Cr concentrated in the reservoir flood areas.
Variability of Cu, Zn, and Cr was captured in single‐factor pollution index and geo‐accumulation index
Effect of reduction in brain amyloid levels on change in cognitive and functional decline in randomized clinical trials: An instrumental variable meta‐analysis
Authors: Pang Menglan , Zhu Ling , Gabelle Audrey , Gafson Arie R. , Platt Robert W , Galvin James E , Krolak‐Salmon Pierre , Rubino Ivana , de Moor Carl , Belachew Shibeshih , Shen Changyu 
Published: August 2022

AbstractIntroductionWhether the reduction in brain amyloid beta (Aβ) plaque alone may substantially slow cognitive and functional decline in patients with dementia or mild cognitive impairment due to Alzheimer's disease (AD) remains debated.MethodsAn instrumental variable meta‐analysis was performed to infer the effect of change in positron emission tomography (PET)–measured Aβ standardized uptake value ratio (SUVR) on cognitive and functional decline.ResultsPooling data from 16 randomized trials demonstrates that each 0.1‐unit decrease in PET Aβ SUVR is associated with a reduction (95% confidence interval) by 0.09 (0.034–0.15), 0.33 (0.12–0.55), and 0.13 (0.017–0.24) point in the average change of the Clinical Dementia Rating–Sum of Boxes, the Alzheimer's Disease Assessment Scale–Cognitive Subscale, and the Mini‐Mental State Examination, respectively.DiscussionThis meta‐analysis provides statistically significant evidence of a likely causal relationship between a reduction in Aβ plaque and a reduction in cognitive and functional decline in patients with AD.Highlights
A widely cited meta‐analysis article concluded amyloid beta reduction does not substantially improve cognition.
We identified data inconsistencies in the initial publication and found new trial data.
We repeated the meta‐analysis after correcting data inconsistencies and adding new trial data.
Updated results suggested statistically significant clinical benefit of amyloid beta reduction.
Amyloid beta is a viable biological target for the treatment and prevention of AD.
Genome‐wide CRISPR‐Cas9 screen reveals a persistent null‐hyphal phenotype that maintains high carotenoid production in Yarrowia lipolytica
Authors: Lupish Brian , Hall Jordan , Schwartz Cory , Ramesh Adithya , Morrison Clifford , Wheeldon Ian 
Published: August 2022

AbstractYarrowia lipolytica is a metabolic engineering host of growing industrial interest due to its ability to metabolize hydrocarbons, fatty acids, glycerol, and other renewable carbon sources. This dimorphic yeast undergoes a stress‐induced transition to a multicellular hyphal state, which can negatively impact biosynthetic activity, reduce oxygen and nutrient mass transfer in cell cultures, and increase culture viscosity. Identifying mutations that prevent the formation of hyphae would help alleviate the bioprocess challenges that they create. To this end, we conducted a genome‐wide CRISPR screen to identify genetic knockouts that prevent the transition to hyphal morphology. The screen identified five mutants with a null‐hyphal phenotype—ΔRAS2, ΔRHO5, ΔSFL1, ΔSNF2, and ΔPAXIP1. Of these hits, only ΔRAS2 suppressed hyphal formation in an engineered lycopene production strain over a multiday culture. The RAS2 knockout was also the only genetic disruption characterized that did not affect lycopene production, producing more than 5 mg L−1 OD−1 from a heterologous pathway with enhanced carbon flux through the mevalonate pathway. These data suggest that a ΔRAS2 mutant of Y. lipolytica could prove useful in engineering a metabolic engineering host of the production of carotenoids and other biochemicals.
Mass spectrometry imaging technology in metabolomics: A systematic review
Authors: Gao Si‐Qi , Zhao Jin‐Hui , Guan Yue , Tang Ying‐Shu , Li Ying , Liu Li‐Yan 
Published: August 2022

AbstractMass spectrometry imaging (MSI) is a powerful label‐free analysis technique that can provide simultaneous spatial distribution of multiple compounds in a single experiment. By combining the sensitive and rapid screening of high‐throughput MS with spatial chemical information, metabolite analysis and morphological characteristics are presented in a single image. MSI can be used for qualitative and quantitative analysis of metabolic profiles and it can provide visual analysis of spatial distribution information of complex biological and microbial systems. Matrix‐assisted laser desorption ionization, laser ablation electrospray ionization and desorption electrospray ionization are commonly used in MSI. Here, we summarize and compare these three technologies, as well as the applications and prospects of MSI in metabolomics.
Increasing patient participation in oncology clinical trials
Authors: Chen Jie , Lu Ying , Kummar Shivaani 
Published: August 2022

AbstractAimTimely recruitment of eligible participants is essential for the success of clinical trials, with insufficient accrual being the leading cause for premature termination of both oncology and non‐oncology trials.MethodsIn this paper we further elaborate on the challenges for patient participation in oncology trials from physician, patient, healthcare system, and some trial‐related perspectives.ResultsWe present strategies such as use of digital healthcare technologies, real‐world data and real‐world evidence, decentralized clinical trials, pragmatic trial designs, and supportive services to increase patient participation.ConclusionsMultifaceted measures are necessary to increase patient participation, especially for those who are under‐represented in cancer trials.
Sequential therapy with darolutamide in patients with non‐metastatic castration‐resistant prostate cancer resistant to enzalutamide or apalutamide
Authors: Fujmoto Saizo , Fujita Kazutoshi , Nishimoto Mitsuhisa , Hamaguchi Mamoru , Kuwahara Ken , Hashimoto Mamoru , Adomi Shogo , Minami Takafumi , Nozawa Masahiro , Yoshimura Kazuhiro , Uemura Hirotsugu 
Published: August 2022

AbstractEnzalutamide, apalutamide, and darolutamide are currently recommended for patients with non‐metastatic castration‐resistant prostate cancer (nmCRPC), but cross‐resistance of androgen receptor‐axis‐targeted therapies (ARAT) occurs. Because darolutamide has a distinct chemical structure to other non‐steroidal antiandrogens, it may be effective for nmCRPC patients resistant to enzalutamide or apalutamide. We retrospectively evaluated the efficacy of switching to darolutamide in patients with nmCRPC. We included nine nmCRPC patients who experienced biochemical progression on enzalutamide or apalutamide and were switched over to darolutamide. Five patients (55.5%) had a PSA response >50% decline after starting darolutamide, with an average of 73% PSA decline. Median progression‐free survival was 6 months. In conclusion, an ARAT switch from enzalutamide or apalutamide to darolutamide might be effective for nmCRPC. Although the validation in a large‐scale cohort is necessary, the switch to darolutamide could be a promising therapeutic option after the progression of 1st line ARAT in nmCRPC patients.
Production of Hydrochars from Lignocellulosic Biomass with and without Boric Acid
Authors: Ercan Betül , Ajagbe Yusuf O. , Uçar Suat , Tekin Kubilay , Karagöz Selhan 
Published: August 2022

AbstractHydrothermal carbonization (HTC) is an important thermochemical process where biomass is converted into coal‐like solid products known as hydrochars. The HTC process is performed in hot‐compressed water under self‐generated pressures. In this work, the HTC of acorn shells was conducted at various temperatures and reaction times with and without boric acid (H3BO3). A high degree of carbonization occurred at 250 °C in non‐catalytic and catalytic 4‐h runs. Hydrochars obtained from non‐catalytic and catalytic runs at 250 °C consisted of spherically carbon particles with diameters ranging from 303 nm to 3.27 μm. Carbon spheres at 200 and 225 °C for 2 h were not observed. The yield and carbon content of the hydrochars were slightly increased by reuse of the process water in thermal runs without catalysts.
Predictive Models of the Steel Beam Capacity Using Artificial Intelligence – Preliminary Studies
Authors: Couto Carlos , Real Paulo Vila 
Published: August 2022

AbstractArtificial intelligence based models, namely using machine learning techniques, have been widely used in different engineering fields, providing accurate, easy‐to‐apply and fast assessment tools to predict the mechanical behaviour. These models not only can be used to increase the inference about the mechanical phenomena of a certain problem but also, for example, allow to quantify the capacity of steel beams, as studied in this work. For that purpose, different models were developed and trained using machine learning algorithms, and it is demonstrated that the capacity predicted by these models surpass the accuracy given by existing analytical models, when using the results obtained with the finite element method as the baseline.
Cold‐Formed Steel Profiles with Multiple Stiffeners Effective Section Calculation Using Alternative Methodology of the EN1993‐1‐3 Standard
Authors: Carvalho C. , Prola L.C. 
Published: August 2022

SummaryIn this article, the use of paragraph 5.5.1 (7) is applied, only for stiffeners, and the use of the numerical results of linear stability analyses (LSA) obtained by the GBT (Generalized Beam Theory) methods is tested for the section, namely the distortional modes, relating them to the formulas currently present in EC3‐1‐3. For comparison and analysis of results, studies present in the bibliography were used that show experimental and numerical results, relevant and representative, of sections with stiffeners. In the calculation of effective sections, the Class4Section application, developed by the authors, is used to run several tests combining EC3‐1‐3 specifications and LSA results.
Open Bim Workflow for the Development of Projects with Steel Structures
Authors: García Alfonso , Gómez Amaya , Assis Paula 
Published: August 2022

AbstractThis article presents the development of a collaborative, multi‐disciplinary and multiuser OpenBIM workflow aimed at meeting the needs of the steel construction industry. The objective is to integrate new technologies into the project development process via a series of tools that facilitate the specialised work of technicians and allow information to be transmitted in standard digital format, reducing time and costs and avoiding a large number of problems that arise due to a lack of coordination between the project phase and the construction phase.
BARRASIM4P – A Digital Platform for the Structural Design of Cold‐Formed Steel Elements from the Company Barraferros
Authors: Carvalho André , Duivenvoorden André , Simões Ana , Grilo Carlos , Prola Luis , Gala Pedro , Martinho Ricardo 
Published: August 2022

AbstractThe use of cold‐formed steel sections as secondary structural elements (purlins) and primary elements of light steel framing (LSF) solutions has had a strong increase in recent years, presenting a high degree of specialization, with specific and optimized geometries for different applications, implying an increased effort for the design of steel structures. This article presents BarraSim4P – a digital platform to support structural design based on Eurocode and developed in partnership between Barraferros and Politécnico de Leiria. The platform aims to support the user in choosing sections considering specified design conditions and code actions in the structure. The platform was also validated with several tests on Barraferros sections with known results.
Human Comfort Investigation of Steel‐Concrete Composite Floors Subjected to Rhythmic Dynamic Actions
Authors: de A. C. Branco Nathalia , de Sousa Felipe Almeida , Santos da Silva José Guilherme 
Published: August 2022

AbstractIn the last decades, several excessive vibrations problems in buildings floors have been observed, due to human activities. Therefore, this research work investigates the dynamic structural behaviour of a steel‐concrete composite floor with total area of 315 m2, when subjected to rhythmic human actions, based on the use of different mathematical formulations in order to define the dynamic loadings. The floor numerical modelling was implemented in the finite element program ANSYS, aiming the dynamic structural response analysis. The results indicate important levels for peak accelerations values, resulting in excessive vibrations and discomfort to the building users.
Structural Performance of Cold‐Formed Steel Moment‐Resisting Frame Assembled by Bolts
Authors: Sato 1 Atsushi , Kitagawa 2 Honoka 
Published: August 2022

AbstractMoment Resisting Frame is one of the framing systems used to construct the building. In this paper, the test results of the beam‐to‐column connection assembled by bolted joints are reported. The beams and columns are cold‐formed steel, and the beams are proposed to use the built‐up members composed of channel‐oriented toe‐to‐toe. Test results from the beam‐to‐column subassemblage showed a stable cyclic behaviour, and the strength deterioration occurred after the ultimate design story drift. The in‐elastic behaviour occurred only in the bolted joint region up to the design story drift level that was expected in the ultimate limit state design.
Analysis of the Global Dynamic Behavior of Metallic Adjacent Building Structures with Non‐Linear Behavior Under Structural Pounding Induced by Seismic Excitations
Authors: Folhento Pedro L. P. , de Barros Rui Carneiro , Braz‐César Manuel T. 
Published: August 2022

AbstractThis study aims to analyse the global dynamic behaviour of two metallic structures with equal or different heights subjected to structural collisions induced by earthquakes that represent a seismic region in Portugal. Numerical models of the structures were developed with a finite element software, and the respective non‐linear behaviour will be idealized using the fibre model at the critical regions considered. The Kelvin‐Voigt model will be used to simulate the magnitude of pounding forces. The phenomenon of structural pounding influences the dynamic response of the structures. This influence is generally more evident when structures are of different heights.