bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrence of an aggressive sacral hemangioma with atypical radiological features after surgical resection: A case report and literature review
Authors: Wang Guan-Xi , Chen Yun-Qing , Wang Yan , wang Bin , Zhou Rui-Zhi , Gao Chuan-Ping 
Published: February 2022

Abstract
Background: Aggressive vertebral hemangiomas (VHs) are uncommon in adults. Although most have typical radiographic features, some present with atypical findings, which makes their diagnosis difficult. Aggressive VHs have a high likelihood of recurrence even after resection.Case presentation: A 52-year-old woman presented with a 3-month history of right lower extremity pain and numbness. On physical examination, the sacrum was tender, her mobility was limited, and right plantar flexion strength was 4/5 on manual muscle testing. Computed tomography (CT) revealed osteolytic bony destruction from S1 to S2. Magnetic resonance imaging (MRI) showed a sacral mass invading the S1 vertebral endplate and compressing the dural sac; the mass was heterogeneously hypointense on T1-weighted imaging, hyperintense on T2-weighted imaging, and heterogeneously enhanced. Six months after surgical resection of the mass, the patient presented with back pain and bilateral extremity numbness. MRI showed lesion recurrence with thecal sac compression.Conclusions: Aggressive VHs may exhibit atypical radiological findings that include osteolytic vertebral bony destruction, spinal canal extension, heterogeneous signal intensity on T1- and T2-weighted imaging, and heterogeneous enhancement. These can make accurate preoperative diagnosis difficult; biopsy may be necessary. Surgical decompression and resection are recommended for aggressive VHs. Nonetheless, recurrence may still occur despite resection.
Metastatic basal cell carcinoma of buccal mucosa: A report of a rare case
Authors: Kimura Taku , Sakata Ken-ichiro , Sato Jun , Ouchi Chisato , Ohga Noritaka , Yanagawa-Matsuda Aya , Hida Kyoko , Kitagawa Yoshimasa 
Published: February 2022

Abstract
Background: Basal cell carcinoma (BCC) is the most common cancer worldwide. Most of BCCs can be detected in the early stages and are generally well controlled with local resection. Despite the high incidence of BCC, metastasis is rarely observed. Metastatic BCCs generally have an aggressive phenotype and are refractory to conventional treatment.Case presentation: We describe a rare case of BCC in which a series of local relapses culminated in metastasis into the oral cavity 10 years after the first diagnosis of cutaneous BCC. We performed surgical resection and postoperative radiotherapy in this patient; 11 months after the final course of radiotherapy, the BCC remains stable, and the patient continues to be monitored regularly.Conclusions: Because metastatic BCC is refractory to current treatment and difficult to control, his treatment history and the pathohistological features of BCC had to be considered in posttreatment planning.
Chromatin state distribution of residue-specific histone acetylation in early myoblast differentiation
Authors: Li Qiao , Li Yuan , Khilji Saadia , Chen Jihong 
Published: February 2022

Abstract
Dynamic changes in epigenetic landscape reflect a critical command of lineage-specific gene expression. In an effort to discern the epigenetic regulatory networks of myogenic differentiation, we have used systematic and integrated approaches to explore multi-omics datasets on global myogenic gene expression, histone acetylation and acetyltransferase occupancy in view of distinct chromatin states. In this brief report, we present a comprehensive assessment regarding the experimental design, quality control, filtering steps and data processing. We also define a gene-level overlap between RNA-seq and ChIP-seq datasets through integrated analyses to offer strategies for future use of the data. Furthermore, our analyses provide a blueprint of chromatin states associated with residue-specific histone acetylation, histone acetyltransferase p300-concomitant epigenetic landscape in committed skeletal myoblasts and differential histone acetylation signatures in early myoblast differentiation. These datasets can be further utilized to delineate the function of muscle-specific regulatory elements governed by other muscle myogenic regulators or signaling molecules.
Estimating the Carbon Content of Oceans using Satellite Sensor Data
Authors: Sooknanan Aadidev , Hosein Patrick 
Published: February 2022

Abstract
The impact of chemical processes in ocean surface waters is far-reaching. Recently, increased significance has been placed on the concentration of Carbon and its compounds and the effects these may have on climate change. Remote-sensing enables near real-time measurement of key sea-surface data which can be used to estimate Carbon levels. We illustrate with the use of hybrid Satellite sensor data. To validate our results we use data collected from cruise ships as the ground truth when training our algorithms. The error rate of our predictor is found to be small and hence the proposed approach can be used to estimate Carbon levels in any ocean. This work improves upon previous research in many ways including the use of sea water salinity as a proxy for Carbon estimates. Binary combinations of typically unary predictor attributes are used for the purposes of predicting the Carbon content of surface water and an inherently non-linear model is used to quantify the relationship.
A Massive Retroperitoneal Tumor – An Unusual Presentation of a Rare Primary Pancreatic Neoplasm
Authors: Clegg Devin J. , Hammond Ryan , Schmocker Ryan K. , Sauls Ryan , Duncan Lisa , Enomoto Laura M. 
Published: February 2022

Abstract
Background:The differential diagnosis for retroperitoneal masses is broad, and includes pancreatic lipomatous hamartoma, a rare but benign disease process. Hamartoma describes outgrowth of tissue native to the organ in which it occurs and is considered a malformation rather than a true neoplasm. Pancreatic hamartomas consist of less than 1% of all hamartomas, and few cases of pancreatic lipomatous tumors with distinct components of pancreatic hamartoma have been described. These tumors are difficult to diagnose on imaging and biopsy alone and can appear malignant with potential for significant mass effect on surrounding organs, leading to surgical intervention for definitive diagnosis. Case Presentation:A 57-year-old male presented with right upper quadrant pain radiating to his left side and back. Ultrasound demonstrated cholelithiasis and an incidentally discovered large retroperitoneal mass. Computed tomography (CT) imaging demonstrated a 14.4 x 4.6 x 16 cm heterogenous, fatty-appearing retroperitoneal mass displacing the colon and small bowel, while abutting the aorta and inferior vena cava (IVC) with no obvious invasion of surrounding structures. He underwent laparoscopic cholecystectomy with biopsy of the mass. Biopsy demonstrated benign adipose tissue and no evidence of malignancy, and his care was transferred to our facility. His postoperative course was complicated by acute congestive heart failure that ultimately delayed definitive surgical intervention for nine months. Progressive growth of the mass was noted on serial imaging as his cardiopulmonary status was optimized. Preoperative CT revealed a 20.2 x 28.2 x 14.1 cm with worsened mass effect on surrounding structures.The patient underwent open resection of the retroperitoneal mass with en bloc resection of the third and fourth portions of the duodenum and the uncinate process of the pancreas. The final pathologic diagnosis was benign lipomatous proliferation with features most consistent with pancreatic lipomatous hamartoma (PLH), with specimen weight of 3810g and overall dimensions of 35 x 27 x 14 cm.Conclusions:PLH is an extremely rare benign tumor, which is notoriously difficult to diagnose with imaging and biopsy alone. This case highlights the difficulty delineating benign from malignant tumors of the pancreas and retroperitoneum.
1,200 Years of NAO-modelled European Climate History
Authors: Morando Marco 
Published: February 2022

Abstract
In his previous article “Arctic Sea Ice’s Amplification as a Complement to Anthropogenic Global Warming”, the author considered the amplification of solar radiation variations, via Arctic Sea’s ice cover albedo, as forcing to climate change. The same model is used here to extend the data input from the period 1200–2100 AD of the previous study to the period 800–2160 AD. In addition, the present study reconstructs the North Atlantic Oscillation index across the 1,200-year period. Based on its correlation with temperature and precipitation, the model reconstructs the climate anomalies due to NAO in several different European and neighbouring regions and sums them to the previous article’s results. The regional overall results of the model are compared with quantitative and qualitative benchmarks from literature, to evaluate the level of accuracy in simulating the historical data. Therefore, the aim of this article is not only to present the modelled results, but also to relate them to the major climatic and agricultural events of European history.
SARS-CoV-2 Omicron infection is associated with high nasopharyngeal viral load
Authors: Salvagno Gian Luca , Henry Brandon M. , Pighi Laura , De Nitto Simone , Montagnana Martina , Lippi Giuseppe 
Published: February 2022

Abstract
Background: We provide here direct comparison of viral load in nasopharyngeal specimens of patients infected by Omicron and former severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants.Methods: We retrospectively reviewed the results of SARS-CoV-2 testing conducted during two corresponding periods of years 2021 and 2022 (i.e., between 3-9 January), characterized by local prevalence of Alpha (>95%; January 2021) and Omicron (>90%; January 2022) SARS-CoV-2 variants, respectively. In both years viral load was quantified using the same method and instrumentation (Seegene Allplex SARS-CoV-2 Assay).Results: The total number of patients with positive SARS-CoV-2 tests was 47 in January 2021 and 118 in January 2022, respectively. The cycle threshold (Ct) values in January 2022 (median Ct value, 27.5; IQR, 23.5-32.7) when the Omicron variant was prevalent were significantly lower than those measured during the same period of the year 2021 (median Ct value, 31.8; IQR, 26.4-37.6; p=0.007), when the Alpha variant was prevalent. The rate of subjects with high nasopharyngeal viral load was over 2-fold higher in January 2022 than in January 2021 (45/118 vs. 10/47; Odds ratio, 2.28 and 95%CI, 1.03-5.03; p=0.041).Conclusions: These results support the suggestion that aerosols released by patients infected by SARS-CoV-2 Omicron variant may contain higher viral particles than those released by subjects infected with previous strains.
Highlighting Exact Matching via Marking Strategies for Ad hoc Document Ranking with Pretrained Contextualized Language Models
Authors: BOUALILI Lila , Moreno Jose , Boughanem Mohand 
Published: February 2022

Abstract
Pretrained language models (PLMs) exemplified by BERT have proven to be remarkably effective for ad hoc ranking. As opposed to pre-BERT models that required specialized neural components to capture different aspects of query-document relevance, PLMs are solely based on transformers where attention is the only mechanism used for extracting signals from term interactions. Thanks to the transformer's cross-match attention, BERT was found to be an effective soft matching model. However, exact matching is still an essential signal for assessing the relevance of a document to an information-seeking query aside from semantic matching. We assume that BERT might benefit from explicit exact match cues to better adapt to the relevance classification task. In this work, we explore strategies for integrating exact matching signals using marker tokens to highlight exact term-matches between the query and the document. We find that this simple marking approach significantly improves over the common vanilla baseline. We empirically demonstrate the effectiveness of our approach through exhaustive experiments on two standard ad hoc benchmarks. Results show that explicit exact match cues conveyed by marker tokens are beneficial for BERT and ELECTRA variant to achieve higher or at least comparable performance. Our findings support that traditional information retrieval cues such as exact matching are still valuable for large pretrained contextualized models such as BERT.
High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor progression and poor prognosis
Authors: Tang Peng , Jia Ran , Gong Lei , Sui Zhilin , Xiao Wanyi , Yang Yueyang , Wu Xianxian , Yu Zhentao , Zhang Hongdian 
Published: February 2022

Abstract
We aimed to investigate the expression and clinical value of PTPRF interacting protein alpha 1 (PPFIA1) in esophageal squamous cell carcinoma (ESCC). The Oncomine, GEPIA, and GEO databases were utilized to explore PPFIA1 mRNA expression in esophageal cancer. The associations of PPFIA1 expression with clinicopathological variables and prognosis were evaluated in the GSE53625 dataset and verified in qRT-PCR-based cDNA array and immunohistochemistry-based tissue microarray (TMA) datasets. The interactions between PPFIA1 and other genes based on the protein-protein interaction (PPI) network was analyzed via the STRING website. We found PPFIA1 expression was obviously upregulated in ESCC tissues versus adjacent normal tissues according to online database analyses (P<0.05). High PPFIA1 expression was significantly associated with several clinicopathological features, including tumor size, histological grade, tumor invasion depth, lymph node metastasis, and TNM stage. High PPFIA1 expression was related to worse outcomes and was identified as an independent prognostic indicator of overall survival in ESCC patients (GSE53625 dataset, P=0.004; cDNA array dataset, P<0.001; TMA dataset, P=0.039). PPI analysis demonstrated that PPFIA1 was highly correlated with multiple genes, including UNC13B, RAB3A, PTPRD, and SYT1. In conclusion, PPFIA1 may be associated with ESCC progression and could be used as a biomarker for prognostic evaluation in ESCC patients.
Reduced Osteoglycin Protein Expression Correlates with Lymph Node Metastasis and Low Differentiation in Human Gastric Cancer
Authors: Qian Chengjia , Zhao Changyong , Gao Qizhong , Gu Jiming , Han Weifeng , Jiang Hui , Jin Liugen , Qi Xiaowei , Fei Bojian , Tu Huiming 
Published: February 2022

Abstract
Background
Gastric cancer (GC) is a highly malignant disease for which the development of novel biomarkers and therapeutic targets is urgently required. Decreased expression of Osteoglycin (OGN) has been observed in the progression of a variety of human cancers; however, the pathologic significance of OGN in GC remains unexplored. We aimed to detect the expression of OGN in gastric cancer tissues, and to evaluated the relationship between OGN expression and the clinico-pathological features in GC patients.
Methods
In this study, the expression levels of OGN were detected by immunohistochemistry (IHC) with the cohort including 44 gastric cancer samples and 40 non-tumorous samples. The data was statistically analyzed using GraphPad Prism 8.0.
Results
We found that OGN expression was downregulated in GC tissues compared to non-tumor counterparts. Furthermore, GC samples with lower OGN levels demonstrated higher lymph node metastasis. Histological analysis further confirmed that OGN downregulation was related to lower differentiation status of GC.
Conclusions
Collectively, our results indicate that dysregulation of OGN might be involved in GC development and that the expression of OGN may serve as a potential biomarker for monitoring of the progression of GC.
Factors influencing warm ischemia time in robot-assisted partial nephrectomy change depending on the surgeon’s experience
Authors: Numakura Kazuyuki , Kobyashi Mizuki , Koizumi Atsushi , Kashima Soki , Yamamoto Ryohei , Nara Taketoshi , Saito Mitsuru , Narita Shintaro , Inoue Takamitsu , Habuchi Tomonori 
Published: February 2022

Abstract
INTRODUCTION: Warm ischemia time (WIT) is a primary concern for robot-assisted laparoscopic partial nephrectomy (RALPN) patients because longer WIT is significantly associated with postoperative deteriorating kidney function. Tumor complexity, determined by the RENAL nephrometry score (RENAL score), can help predict surgical outcomes, but it is unclear what RENAL score and clinical factors affect WIT. This study explored the clinical factors predicting long WIT in RALPN.MATERIALS AND METHODS: In our institute, 174 RALPNs were performed between November 2013 and February 2021, of which 114 were performed by a single surgeon and included in this study. Clinical staging and the total RENAL score were determined based on preoperative CT scans. The cases were divided into three groups based on experience: period 1: 1–38, period 2: 39–76, and period 3: 77–114. The clinical factors associated with longer WIT were analyzed per period. RESULTS: The overall median tumor diameter was 32 mm, and one patient had a positive surgical margin, but there were no cancer-related deaths. In total, there were 18 complications (15.8 %). Periods 2 and 3 had larger tumor diameters (p<0.01) and worse preoperative kidney function (p=0.029) than period 1. A RENAL L-component score of 3 was associated with longer WIT in period 3 (odds ratio: 3.900; 95 % confidence interval: 1.004–15.276; p = 0.044), but the tumor diameter and the total RENAL score were not.CONCLUSIONS: A large tumor in the central lesion indicated by the RENAL L-component score was associated with increased WIT in RALPN.
Perinatal depression and anxiety among Chinese women during the outbreak of the COVID-19 Delta variant
Authors: Liu Bing , Li Yingting , Huang Yunbo , Li Xiaolin , Yang Shuai , Fu Tingting , Peng Hongyun , Zhang Xia , Luo Taizhen , Chen Min 
Published: February 2022

Abstract
Background: This study aimed to assess the COVID-19 Delta variant impact on the incidence of depressive and anxiety symptoms in pregnant women in Guangdong Province, China, as well as to identify related risk factors.Methods: A three-week, multisite, cross-sectional study was conducted from June to July 2021 to evaluate the mental health status of pregnant women by the Edinburgh Postnatal Depression Scale. Approximately 1,450 women from 25 Guangdong hospitals were included in the study. We employed the Edinburgh Postnatal Depression Scale to assess symptoms of maternal depression and anxiety. Risk factors and relevance rates were analyzed.Results: Pregnant women who were determined to be underweight before pregnancy, primiparous, above 35 years of age, employed full-time, of middle income status, and had comfortable living arrangements were at higher risk of developing depression and anxiety during a COVID-19 outbreak.Conclusion: The occurrence of the COVID-19 Delta variant has increased the risk of mental disorders in pregnant women, which include thoughts of self-harm. Programs designed to address maternal stress as well as isolation such as constructive risk, communication, and providing psychological first aid may be particularly useful to avoid negative outcomes in pregnant women and their fetuses.
WITHDRAWN: Ward based teaching in a specialised clinical area. The outcome of implementing an induction pack for nursing staff new to the ward setting. Pilot study.
Authors: Ciesielski Krzysztof 
Published: February 2022

Abstract
Background: This pilot study presents a summary and evaluation of results from an 18-month project undertaken in an inpatient ward in clinical haematology. It was recognised that the level of basic clinical haematology knowledge varied amongst new nursing staff therefore, to improve the experience and to provide the same background knowledge, the induction pack was introduced. The aims of this study are to investigate whether the induction pack was useful to new nursing staff and to assess if more time is needed to complete the induction pack. Methods: This quantitative pilot study included 10 registered nursing staff who were new to the clinical area. Quantitative data was collected with the use of a self-completion survey composed of 8 short questions. Data was analysed with the use of percent proportion formula. Results: Final results are presented in a pie chart as percentages. Members of the staff participating in this study agreed with a total of 90% and disagreed with a total of 10% the induction pack was useful. The induction pack had a total of 60% success rate in being completed within the scheduled time frame. Conclusion: Overall, the induction pack has made a positive impact and contribution to the ward-based teaching. The aims of the study were met and the results showed that there were strong agreement or agreement between participants that the induction pack was useful. The results also suggested that nursing staff who are new to the clinical area, may needed more time to complete the induction pack.
Randomized Trial of Surveillance with Abbreviated MRI in Women with a Personal History of Breast Cancer– Impact on Patient Anxiety and Cancer Detection
Authors: Fonseca Marina Mohallem , Alhassan Tasneen , Nisha Yashmin , Koszycki Diana , Schwarz Betty Anne , Segal Roanne , Arnaout Angel , Ramsay Tim , Lau Jacqueline , Seely Jean Morag 
Published: February 2022

Abstract
Background: Abbreviated breast MRI (A-MRI) substantially reduces the image acquisition and reading times and has been reported to have similar diagnostic accuracy as a full diagnostic protocol but has not been evaluated prospectively with respect to impact on psychological distress in women with a prior history of breast cancer (PHBC). This study aimed to determine if surveillance mammography (MG) plus A-MRI reduced psychological distress and if A-MRI improved cancer detection rates (CDR) as compared to MG alone. Methods: This prospective controlled trial of parallel design was performed at a tertiary cancer center on asymptomatic women with PHBC who were randomized into two groups: routine surveillance with MG or intervention of MG plus A-MRI in a 1:1 ratio. Primary outcome was anxiety measured by four validated questionnaires at three different time-points during the study. Other parameters including CDR and positive predictive value for biopsy (PPV3) were compared between imaging modalities of MG and A-MRI. Tissue diagnoses or 1 year of follow-up were used to establish the reference standard. Linear mixed models were used to analyze anxiety measures and Fisher’s exact test to compare imaging outcomes. Results: 198 patients were allocated to either MG alone (94) or MG plus A-MRI (104). No significant group difference emerged for improvement in trait anxiety, worry and perceived health status (all Time-by-surveillance group interaction ps>.05). There was some advantage of A-MRI in reducing state anxiety at Time 2 (p<.05). Anxiety scores in all questionnaires were similarly elevated in both groups (50.99+/-4.6 with MG alone vs 51.73+/-2.56 with MG plus A-MRI, p>0.05) and did not change over time. A-MRI detected 5 invasive cancers and 1 ductal carcinoma in situ (DCIS), and MG detected 1 DCIS. A-MRI had higher incremental CDR (48/1000(5/104) vs MG 5/1000(1/198, p=0.01)) with no difference in PPV3 (A-MRI 28.6% (6/21) vs MG 16.7% (1/6, p>.05). Conclusion: Compared to MG alone, A-MRI had significantly higher incremental cancer detection in PHBC. Despite a higher rate of biopsies, A-MRI had no demonstrable impact on anxiety, worry, and perceived health status. Trial registration: ClinicalTrials.gov (NCT02244593). Prospectively registered on Sept. 14, 2014.