bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective or Inhibitory Effect of Pharmacological Therapy on Cardiac Ischemic Preconditioning: A Literature Review
Authors: de Paula Leonardo Jorge Cordeiro , Uchida Augusto Hiroshi , Rezende Paulo Cury , Soares Paulo , Scudeler Thiago Luis 
Published: August 2022

Abstract:Ischemic preconditioning (IP) is an innate phenomenon, triggered by brief, non-lethal cycles of ischemia/reperfusion applied to a tissue or organ that confers tolerance to a subsequent more prolonged ischemic event. Once started, it can reduce the severity of myocardial ischemia associated with some clinical situations, such as percutaneous coronary intervention (PCI) and intermittent aortic clamping during coronary artery bypass graft surgery (CABG). Although the mechanisms underlying IP have not been completely elucidated, several studies have shown that this phenomenon involves the participation of cell triggers, intracellular signaling pathways, and end-effectors. Understanding this mechanism enables the development of preconditioning mimetic agents. It is known that a range of medications that activate the signaling cascades at different cellular levels can interfere with both the stimulation and the blockade of IP. Investigations of signaling pathways underlying ischemic conditioning have identified a number of therapeutic targets for pharmacological manipulation. The aim of this review is to present and discuss the effects of several medications on myocardial IP.
Association Between Telomere Length and Cardiovascular Risk:
Pharmacological Treatments Affecting Telomeres and Telomerase Activity
Authors: Zafirovic Sonja , Macvanin Mirjana , Stanimirovic Julijana , Obradovic Milan , Radovanovic Jelena , Melih Irena , Isenovic Esma 
Published: August 2022

Abstract:
Telomeres represent the ends of chromosomes, and they are composed of an extensive number of – TTAGGG nucleotide sequence repeats in humans. Telomeres prevent chromosome degradation, participate in stabilization, and regulate the DNA repair system. Inflammation and oxidative stress have been identified as important processes causing cardiovascular disease and accelerating telomere shortening rate. This review investigates the link between telomere length and pathological vascular conditions from experimental and human studies. Also, we discuss pharmacological treatments affecting telomeres and telomerase activity.
Graviola Protects Against Hepatic Toxicity Associated with DMBA induced
Breast Cancer via Restoration of Antioxidants and Attenuation of
Inflammatory Pathways
Authors: Zeweil Mohamed M. , Sadek Kadry M. , Abouzed Tarek K. , Wasef Lamiaa , Saleh Hamida , Albogami Sarah M. , Alotaibi Saqer S. , Alsayegh Abdulrahman A. , Alexiou Athanasios , Batiha Gaber El-Saber 
Published: August 2022

Aims:
This study documented hepatic tissue's protective activity against oxidative damage
mediated experimental models of breast cancer.

Background:
Gaviola has a long history of improving the protection mechanism against many diseases as
an antioxidant and anticancer dietary agent.

Objective:
The purpose of this study is to establish changes in hepatic profiling, antioxidants, inflammatory
cytokine expression, and DMBA-induced hepatic histopathology of mammalian rats.

Methods:
7,12-dimethylbenz[a] anthracene (DMBA), PAHs, used orally in female Sprague Dawley rats
Fifty-seven days-old with breast cancer single-dose diluted in sesame oil of 20 mg/kg/body weight. The
cancer-bearing animals had 45 days gastrogavagated at 200 mg/kg/body weight with Graviola. The serum
samples were taken at the end of the experiment. The rats were sacrificed to establish the hepatic protective
activity of the Graviola by testing hepatic and oxidative stress markers.

Results:
Graviola therapy shows that enzymatic and non-enzymatic antioxidants and lipid peroxide levels
have increased efficiency and have restored the high activity of hepatic marker enzymes such as ALT,
AST, ALP, and GGT. To date, hepatic expression of nuclear factor erythroid 2-like 2 (Nfe2l2) and nuclear
factor kappa B subunit 1 (Nfkb1) mediated rats have normalized. In addition, histological observations
have demonstrated that Graviola's treatment effectively protects the liver from the oxidative damage
caused by DMBA, reinforcing its hepatic defensive nature.

Conclusion:
Graviola therapy improves the efficiency of both enzymatic and non-enzymatic antioxidants
and lipid peroxide levels. It also helps in the restoration of other liver enzymes.
Research Progress in Regulation of Ferroptosis by Epigallocatechin-3-
gallate in Tumor Cells
Authors: Li Yan , Zhang Lei , Dong Rongjian 
Published: August 2022

Abstract:
Ferroptosis is an identified form of regulated cell death different from cell necrosis, autophagy,
and apoptosis, characterized by iron-dependent accumulation of lipid reactive oxygen species. The processes
of ferroptosis are mainly related to iron metabolism disorder, inactivation of glutathione peroxidase
4 (GPX4), and coenzyme Q10-dependent pathway. Inducing ferroptosis is considered a promising strategy
to fight against cancers, especially apoptosis-resistant tumors. Epigallocatechin-gallate (EGCG) is the
predominately active substance in green tea, which is widely consumed worldwide as a beverage. Recently,
EGCG has been proved to play an important role in inducing ferroptosis by modulation of the iron
metabolism and promotion of glutathione peroxidase 4 (GPX4) protein degradation. Therefore, this review
mainly elaborates the regulating effects of EGCG on ferroptosis, aiming to create a new space for
the research and development of novel anticancer drugs.
The Assessment of the Quality of Life in Patients with Rheumatoid Foot
Authors: Wisłowska Małgorzata , Chruściak Monika , Kowalik Ilona , Chruściak Tomasz 
Published: August 2022

Background:The negative effects of rheumatoid arthritis (RA) are multi-dimensional. Foot deformities lead to disability, pain, and impaired quality of life.Objective:Identifying the difficulties in functioning rheumatoid foot and assessing the quality of life in this aspect.Materials and Methods:The material included 50 patients of Rheumatology Policlinic of the Central Clinical Hospital of Interior Affairs in Warsaw and a matched control group of 50 individuals without RA. The degree of foot joint damage was assessed using the Manchester scale, lower limb movement and quality of life using the American Orthopedic Foot and Ankle Society Score and HAQ.Results:The duration of symptoms was 16.0 ± 8.9 years. High activity of RA measured by the DAS was observed in 20% of patients, moderate in 26%, and low in 54%. The most common foot deformities were: hammer toes (82%), longitudinal flat feet (74%), and hyperkeratosis (56%). The least frequent were: stiff toe (38%) and overlapping fingers (28%). In the RA group, the outcomes of the FAOS questionnaire were statistically significantly worse than in the control group in all categories (p<0.001). The worst-rated domain was the sport and recreation subscale (median 55.0), the best daily activity (median 86.8). The strongest relationship was demonstrated between the FAOS and HAQ indices. Spearman's HAQ correlation coefficient with the ADL subscale was r=-0.85, p<0.001; with the QOL, sport/recreation and pain subscales moderate, it was r=-0.72; r= 0.71, p <0.001.Conclusions:Lower limb movement function and quality of life are worse in RA patients; pain accompanies climbing and descending stairs; running and jumping require effort.
Anxiety, Depression, and Fear among People with and without Diabetes
During the Transmission of SARS-CoV-2 Omicron Variant
Authors: Robert Asirvatham Alwin , Al Dawish Abdulrahman , Al Dawish Raseel Mohammed , Al Mutairi Safa Muqhim , Alanazi Maryam Salem , Al Dawish Mohamed Abdulaziz 
Published: August 2022

Background and Aim:
The present study aimed to evaluate the anxiety, depression, and
fear in people with and without diabetes during the transmission of the SARS-CoV-2 Omicron variant.

Methods:
In this comparative study (n= 353), people with diabetes (n= 121) and those without diabetes
(n= 232) were investigated for physiological aspects of COVID-19 during the SARS-CoV-2
Omicron variant outbreak. This study was performed at the Prince Sultan Military Medical City
(PSMMC), Riyadh, Saudi Arabia. On request, the participants responded to the survey questionnaires,
providing data on demographics, Generalized Anxiety Disorder (GAD-7), and Patient
Health Questionnaire-2 (PHQ-2) to screen for anxiety, depression, and COVID-19-related fears.

Results:
The GAD statement revealed a significantly higher degree of nervousness and anxiety
among people with diabetes when compared to people without diabetes (P = 0.001). For the other
GAD statements, no statistical difference was observed between the responses of people with and
without diabetes, including the overall GAD-7 (P = 0.091). The PHQ-2 statement, concerning a
feeling of depression or hopelessness noted a significant escalation among diabetes compared to
nondiabetes (P = 0.004). Furthermore, in the overall PHQ-2, a significant escalation (P = 0.011)
was noticed among people with diabetes compared to nondiabetes. In addition, people with diabetes
had a significantly high (P = 0.037) COVID-19-related fear reported, compared to people without
diabetes.

Conclusion:
The need for comprehensive research is urgent, as it will facilitate a better understanding
of the physiological aspects of COVID-19 for patients with diabetes.
Imaging Profile After Treatment with Tocilizumab in COVID-19: A Case
Series
Authors: Tondo Pasquale , Lacedonia Donato , Scioscia Giulia , Fuso Paolo , De Pace Cosimo C. , Sassani Ennio V. , Foschino Barbaro Maria Pia 
Published: August 2022

Introduction::
COVID-19 is a pandemic disease, mainly affecting the respiratory tract, triggering
an inflammatory cascade complicated by multiorgan failure up to death. Among the tested medications
for this disease, tocilizumab appears to act directly on the inflammatory cascade, improving
COVID-19 outcomes. For this reason, we have tested the efficacy of tocilizumab on lung damage using
chest computed tomography (CT).

CASE Presentation:
The study was conducted on twenty-one hospitalised COVID-19 patients between
March-June 2020. Patients were divided into 2 groups according to the therapies administered
(TCZ group= treatment with tocilizumab and NTZ group= other therapies). At admission, TCZ group
presented worse laboratory test values, respiratory profile (PaO2/FiO2 ratio: 145.37±38.16 mmHg vs
257.9±95.3 mmHg of NTZ group, P<0.01) and radiological signs (multifocal opacity at chest-X-ray:
88% vs 23% of NTZ group, P<0.01). After performing chest CT during the clinical recovery, the scans
of the 2 groups were compared and we observed that some features (e.g., ground glass opacity, consolidation
and parenchymal bands) were less marked in the TCZ group.

Conclusion:
In our study, patients treated with tocilizumab presented a worse overall clinical and radiological
profile at admission, but the control CT showed a similar imaging profile to patients treated
with standard therapy. Based on this evidence, we may suggest that tocilizumab plays an important
role in COVID-19 patients in reducing lung inflammation.
Radiomics and Artificial Intelligence in Predicting Axillary Lymph Node
Metastasis in Breast Cancer: A Systematic Review
Authors: Eldaly Abdullah S. , Avila Francisco R. , Torres-Guzman Ricardo A. , Maita Karla , Garcia John P. , Serrano Luiza Palmieri , Forte Antonio J. 
Published: August 2022

Background:
Breast cancer is the most common malignancy and the second most common cause of death in women worldwide. Axillary lymph node metastasis (ALNM) is the most significant prognostic factor in breast cancer. Under the current guidelines, sentinel lymph node biopsy (SLNB) is the standard of axillary staging in patients with clinically-node negative breast cancer. Despite the minimally invasive nature of SLNB, it can cause short and long-term morbidities including pain, sensory impairment, and upper limb motor dysfunction. However, lymphedema remains the most feared adverse event, and it affects 7% of patients within 36 months of follow-up.
Recently, we have witnessed the implication of radiomics and artificial intelligence domains in the diagnosis and follow-up of many malignancies with promising results. Therefore, we have conducted a systematic search to investigate the potentials of radiomics and artificial intelligence in predicting ALNM.

Methods:
Four electronic databases were searched: PubMed, Scopus, CINAHL, and Web of Science. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analysis as our basis of organization.

Results:
For radiomics, area under the curve (AUC) for the included studies ranged from 0.715 to 0.93. Accuracy ranged from 67.7% to 98%. Sensitivity and specificity ranged from 70.3% to 97.8% and 58.4% to 98.2%, respectively. For other artificial intelligence methods, AUC ranged from 0.68 to 0.98, while accuracy ranged from 55% to 89%.

Conclusion:
The results of radiomics and artificial intelligence in predicting ALNM are promising. However, validation as a substitute to SLNB requires more substantial evidence from large randomized trials.
A Huge Gastric Angiolipoma Presenting with Acute Upper Gastrointestinal
Hemorrhage: A Case Report
Authors: Park Sung Bin , Choi Joo Hyeok , Lee Jong Beum , Lee Tae-Jin , Park Hyun Jeong , Lee Eun Sun 
Published: August 2022

Background:
Angiolipoma is a benign neoplasm mainly composed of adipose tissue and
proliferating blood vessels and is relatively rare in the gastrointestinal tract. And among them, gastric
angiolipomas are extremely rare and tend to be small.

Case Presentation:
We report the clinical and imaging features of a patient with a huge angiolipoma in
the stomach and an episode of hematemesis and melena, caused by the ulceration of the gastric mucosa
overlying the gastric subepithelial angiolipoma revealed by the endoscopic evaluation. The patient was
anemic, and the anemia resolved after local surgical resection of the tumor. We also reviewed the imaging
and histological features of the presenting gastric angiolipoma.

Conclusion:
Radiologists should be aware of this rare benign gastric tumor that may present with gastrointestinal
hemorrhage.
Improved Bioavailablity of Curcumin by Derivatisation with Isoleucine in
Plasma and Reproductive Tissues of Female Rats is Mainly Due to Altered
Affinity for P-gp Transporter
Authors: Muthukumar Serva Peddha , Divyashree Sheshadri , Janhavi Prakash , Kumar Nanjundaswamy Vijendra , Bettadaiah Bheemanakere Kempaiah 
Published: August 2022

Aim:
The present study aimed to investigate the bioavailability of curcumin conjugated
with isoleucine.

Background:
Curcumin has various health beneficiary properties; however, it is poorly bioavailable
because of its insolubility in water, poor absorption and quick systemic elimination. Hence,
any approach that could improve bioavailability is necessary.

Objective:
The objective of the present study is to examine whether the bioavailability and biodistribution
of curcumin is improved upon derivatisation with isoleucine than that of native curcumin.

Methods:
About 0.1 g/kg bw of curcumin and its isoleucine-derivative were administered to fasting
rats. Then the blood and tissue samples were collected at different time intervals (0, 1800,
3600, 7200, 14400, 28800, 43200, 86400, and 172800 seconds) and processed for the extraction of
curcumin and its derivative with methanol. The processed samples were subjected to HPLC analysis
and compared with the standard curcumin and its derivative. The results were analysed using
the software, PKSolver, for determining the bioavailability and biodistribution. Further, the docking
studies were carried out to better understand the results obtained.

Results:
We found that isoleucine-curcumin conjugates have better bioavailable in plasma, ovary
and uterus in the experimental rats. The curcumin and its isoleucine-derivative was detected to be
maximum at 14400 seconds. However, the concentration of isoleucine-derivative of curcumin was
significantly high at Tmax compared to native curcumin. Further, curcumin and its derivative were
found in the reproductive organs only at 28800 seconds, 43200 seconds and 86400 seconds. The
binding energy of isoleucine-derivative of curcumin with p-glycoprotein transporter was found to
be more compared to the native form. This may be the reason for the increased bioavailability of
isoleucine-derivative of curcumin.

Conclusion:
The isoleucine-curcumin conjugate has better bioavailability compared to curcumin
both in plasma and reproductive organs.
An Improved Amperometric D-amino Acid Biosensor Based on Immobilization
of D-Amino Acid Oxidase on Nanocomposite of Chitosan/Fe3O4NPs/
cMWCNT/GC Electrode
Authors: Pundir Chandra Shekhar , Lata Suman , Batra Bhawna , Ahlawat Jyoti 
Published: August 2022

Objective:
An improved amperometric D aminoacid (DAA) biosensor was fabricated by immobilizing
covalently, D-amino acid oxidase (DAAO) onto nanocomposite of chitosan (CHIT)/ iron oxide
nanoparticles (Fe3O4NPs)/ carboxylated multiwalled carbon nanotubes (cMWCNT)/ electrodeposited
onto glassy carbon (GC) electrode

Methods:
The iron oxide nanoparticles (Fe3O4NPs) were prepared and characterized by UV spectroscopy,
transmission electron microscopy (TEM) and Fourier transform infrared (FTIR) spectroscopy.

Results:
The enzyme electrode (DAAO/CHIT/ Fe3O4NPs/cMWCNT/GC) was characterized by scanning
electron microscopy (SEM), FTIR and electrochemical impedance spectroscopy (EIS). The biosensor
showed maximum response within 2s at pH 8.0, 35°C and potential of 0.09V vs. Ag/AgCl with a linear
working range of 0.02-0.80 μM, sensitivity of 919.29 μAcm-2μM-1 and detection limit of 0.02 μM.

Conclusion:
The within and between batch coefficients of variation (CVs) for determination of DAA by
present biosensor were 2.35% and 2.87%, respectively. The level of DAA in real fruit juices as measured
by the present biosensor matched with those by the standard spectrophotometric method with a good correlation
(r = 0.978). The biosensor lost 30 % of its initial activity over a period of 120 days when stored
dry at 4°C.
Drug Sensitivity Testing for Cancer Therapy, Key Areas
Authors: Lu Da-Yong , Lu Ting-Ren , Yarla Nagendra Sastry , Xu Bin 
Published: August 2022

Aims:
Cancer is a high-mortality disease (9.6 million deaths in 2018 worldwide). Given
various anticancer drugs, drug selection plays a key role in patient survival in clinical trials.

Methods:
Drug Sensitivity Testing (DST), one of the leading drug selective systems, was widely
practiced for therapeutic promotion in the clinic. Notably, DSTs assist in drug selection that benefits
drug responses against cancer from 20-22% to 30-35% over the past two decades. The relationship
between drug resistance in vitro and drug treatment benefits was associated with different tumor
origins and subtypes. Medical theory and underlying DST mechanisms remain poorly understood
until now. The study of the clinical scenario, sustainability and financial support for mechanism
and technical promotions is indispensable.

Results:
Despite the great technical advance, therapeutic prediction and drug selection by DST
needs to be miniature, versatility and cost-effective in the clinic. Multi-parameters and automation
of DST should be a future trend. Advanced biomedical knowledge and clinical approaches to translating
oncologic profiles into drug selection were the main focuses of DST developments. With a
great technical stride, the clinical architecture of the DST platform was entering higher levels (drug
response testing at any stage of cancer patients and miniaturization of tumor samples).

Discuss:
The cancer biology and pharmacology for drug selection mutually benefit the clinic.
New proposals to reveal more therapeutic information and drug response prediction at genetic, molecular
and omics levels should be estimated overall.

Conclusion:
By upholding this goal of non-invasive, versatility and automation, DST could save
the life of several thousand annually worldwide. In this article, new insights into DST novelty and
development are highlighted.
Combining Network-based and Matrix Factorization to Predict Novel
Drug-target Interactions: A Case Study Using the Brazilian Natural
Chemical Database
Authors: Martins Ronald Sodre , da Costa Gomes Marcelo Ferreira , Caffarena Ernesto Raul 
Published: August 2022

Background:
Chemogenomic techniques use mathematical calculations to predict new DrugTarget Interactions (DTIs) based on drugs' chemical and biological information and pharmacological
targets. Compared to other structure-based computational methods, they are faster and less expensive.
Network analysis and matrix factorization are two practical chemogenomic approaches for predicting
DTIs from many drugs and targets. However, despite the extensive literature introducing various
chemogenomic techniques and methodologies, there is no consensus for predicting interactions using a
drug or a target, a set of drugs, and a dataset of known interactions

Methods:
This study predicted novel DTIs from a limited collection of drugs using a heterogeneous ensemble based on network and matrix factorization techniques. We examined three network-based approaches and two matrix factorization-based methods on benchmark datasets. Then, we used one network approach and one matrix factorization technique on a small collection of Brazilian plant-derived
pharmaceuticals.

Results:
We have discovered two novel DTIs and compared them to the Therapeutic Target Database to
detect linked disorders, such as breast cancer, prostate cancer, and Cushing syndrome, with two drugs
(Quercetin and Luteolin) originating from Brazilian plants.

Conclusion:
The suggested approach allows assessing the performance of approaches only based on
their sensitivity, independent of their unfavorable interactions. Findings imply that integrating network
and matrix factorization results might be a helpful technique in bioinformatics investigations involving
the development of novel medicines from a limited range of drugs.
Inter-changeability Between Anterior Segment Optical Coherence Tomography and Scheimpflug Imaging in the Evaluation of Corneal Opacity
Authors: Mounir Amr , Abdellah Marwa Mahmoud , Zidan Omar Fawzy , Mostafa Engy Mohamed 
Published: August 2022

Purpose
To compare the results of corneal evaluation, either the total corneal thickness and corneal opacity depth by both technologies AS- OCT and Scheimpflug imaging by Sirius Scheimpflug placido topography.

Methods
sixty-eight eyes of sixty- eight consecutive patients with corneal opacities were examined by both AS-OCT and Sirius Scheimpflug imaging. Corneal thickness and corneal opacity depth were measured and compared determining the interchangeability using Bland–Altman plotting.

Results
Total corneal thickness was (470.32±62.10) and (463.47±56.47) by AS. OCT and Sirius Scheimpflug imaging, respectively (P value = 0.8).
While the actual measurement of corneal opacity, corneal opacity depth was (135.39±119) and (85.45±128) by AS-OCT and Siris Scheimpflug imaging respectively with P value (0.004).

Conclusion
AS-OCT and Scheimpflug imaging Sirius may be used interchangeably for measuring both total corneal thickness, while in the determination of corneal opacity depth. the AS-OCT is superior to Scheimpflug imaging in the accuracy of determination of actual boundaries of the corneal opacity.