bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbon Nanotube Uptake in Photosynthetic Bacteria for Near-infrared Imaging and Enhancing Bioelectricity Generation in Living Photovoltaics
Authors: Boghossian Ardemis Anoush , Antonucci Alessandra , Reggente Melania , Roullier Charlotte , Gillen Alice , Lambert Benjamin , Mouhib Mohammed 
Published: July 2022

The internalization of fluorescent single-walled carbon nanotubes (SWCNTs) in photosynthetic microbes can be exploited for applications ranging from energy conversion and imaging to biomolecule delivery. The internalization of these nanoparticles are largely controlled by the permeability of the surrounding microbial cell walls, which vary in surface charge density, composition, thickness, and elasticity across different species of microbes. Since these properties play a critical role in controlling internalization, the extension of SWCNT-based technologies to prokaryotes thus requires a comparative assessment of uptake across different species.
Herein, we extend a technology previously developed for internalizing SWCNTs in prokaryotes, specifically unicellular Synechocystis sp. PCC 6803, to Nostoc punctiforme, a filamentous cyanobacterial strain known to differentiate into heterocysts under nitrogen starvation. Heterocysts are specialized compartments within the filament that are capable of nitrogen fixation. These compartments possess cell walls that are distinct from vegetative cells, conferring heterocysts with relatively reduced permeability and increased resistance to mechanical and osmotic stress. Using a combination of near-infrared (NIR) fluorescence, scanning electron microscopy (SEM), and Raman spectroscopy, we investigate the effects of different cell-wall architectures and SWCNT functionalizations on internalization. We specifically examine the effects of these distinct SWCNT-cell interactions on long-term cell integrity, activity, and viability. We further show that local variations in membrane structure can dictate the extent of SWCNT association and uptake in Nostoc cells. This dependency of nanoparticle internalization on cell type can be exploited for the development of novel cell-specific staining and imaging technologies.
Measure and Analysis of Carbon Nanotube Diffusion in 3D
Authors: Lee Antony , Caicedo Karen , Grésil Quentin , Bon Pierre , Cognet Laurent 
Published: July 2022

Measuring carbon nanotube diffusion is complex in 3D liquid environments. Single molecule fluorescence microscopy commonly provides nanotube trajectories in the 2D imaging plane with nanometer precisions but assessing the third dimension is more challenging task. To this aim, We will present two strategies based on point-spread function (PSF) engineering [1] or self-interfering PSF [2]. Because nanotubes are not spherical objects, 3D angular diffusion of the nanotubes shall also be considered. We will show that using a high-frame rate imaging (kHz) of nanotube movements, the autocorrelation time of nanotube fluorescence intensity can be computed in order to measure the rotational diffusion coefficient of the nanotubes. This further allows to estimate the length of the nanotubes either from the rotational diffusion coefficients alone, or by combining translational and rotational diffusion coefficients which has the advantage to avoid the requirement of knowing the solution viscosity or the SWCNT hydrodynamic diameter [3].

References

[1] Gresil, Lee, et al. In preparation
[2] Caceido, Lee, et al. In preparation
[3] Lee & Cognet J. Appl. Phys. 128 (2020) 224301
(Invited) Solution-Processable Carbon Nanotube Nanohybrids for Multiplexed Photoresponsive Devices
Authors: Palma Matteo 
Published: July 2022

In this talk, we will present assembly strategies for the construction in aqueous solution of hybrid nanostructures comprising inorganic semiconducting nanoparticles (CdS and PbS) grown on DNA-wrapped carbon nanotubes employed as templates. The organization of these hybrids in nanoscale devices, including ones employed for multiplexed photoinduced electrical response, will be discussed.
In particular, solution-processed multiplexed photoresponsive devices were fabricated from CdS-CNT and PbS-CNT nanohybrids,[1] displaying a sensitivity to a broad range of illumination wavelengths (405,532, and 650 nm). DNA-CNT and CdS-DNA-CNT devices show a drop in the current while PbS-DNA-CNT’s current increases upon light illumination, indicating a difference in the operational mechanisms between the hybrids. Furthermore, the ON/OFF photoresponse of PbS-DNA-CNT is only 1 s as compared to 200 s for the other two nanohybrid devices.
The mechanisms of the different photoresponses were investigated by comparing the performance under an inert and air atmosphere, and gate dependence device analysis and transient absorption spectroscopy measurements were also conducted. The results revealed that photoinduced oxygen desorption is responsible for the slower photoresponse by DNA-CNT and CdS-DNA-CNT, while photoinduced charge transfer dominates the much faster response of PbS-DNA-CNT devices.[1] The strategy developed is of general applicability for the bottom-up assembly of CNT-based nanohybrid optoelectronic systems and the fabrication of solution-processable multiplexed devices.
[1] Adv. Funct. Mater. 2021, 31, 2105719

Figure 1
Arrays of Bundled Semiconducting Carbon Nanotubes for High Transconductance Field Effect Transistors
Authors: Foradori Sean , Arnold Michael , Gopalan Padma , Dwyer Jonathan H. , Suresh Anjali 
Published: July 2022

Forming aligned arrays from bundled (rather than individualized) semiconducting carbon nanotubes can beneficially increase the density of nanotubes in the channel of field effect transistors (FETs). Here, we prepare aligned arrays of bundles at a density of 20 – 50 bundles μm-1 via tangential flow interfacial self-assembly and show that bundles can increase the transconductance of FETs when a strong gate is used. When encapsulated with an ion gel gate, the transconductance and saturated on-current increases as the diameter of the bundles increases. Devices tested at -0.6 V drain voltage using an ion gel gate achieve transconductance as high as 50 μS per bundle and 2000 μS μm-1 and on-state current as high as 1.7 mA μm-1. At low drain voltages the off-current also increases with bundling, but on/off ratios of ~105 are possible if the bundle size is limited to ~ 5 nm. Radio frequency devices with very strong gates may benefit from the increased device performance by using moderately bundled semiconducting carbon nanotube arrays.
Figure Caption: Panel (a) has transfer curves from 4 devices each with ~42 CNTs-bundles μm-1 but with different median bundle heights. Devices with larger bundles have higher transconductance and saturated on-currents. Panel (b) shows the transconductance per bundle vs the median bundle height and shows the positive correlation between bundle size (height) and transconductance per bundle. Panel (c) is a rendering of a large bundle formed from polymer wrapped CNTs.

Figure 1
Sensory Nerves Impede the Formation of Tertiary Lymphoid Structures and Development of Protective Antimelanoma Immune Responses
Authors: Vats Kavita , Kruglov Oleg , Sahoo Bikram , Soman Vishal , Zhang Jiying , Shurin Galina V. , Chandran Uma R. , Skums Pavel , Shurin Michael R. , Zelikovsky Alex , Storkus Walter J. , Bunimovich Yuri L. 
Published: July 2022

Abstract

Peripheral neurons comprise a critical component of the tumor microenvironment (TME). The role of the autonomic innervation in cancer has been firmly established. However, the effect of the afferent (sensory) neurons on tumor progression remains unclear. Utilizing surgical and chemical skin sensory denervation methods, we showed that afferent neurons supported the growth of melanoma tumors in vivo and demonstrated that sensory innervation limited the activation of effective antitumor immune responses. Specifically, sensory ablation led to improved leukocyte recruitment into tumors, with decreased presence of lymphoid and myeloid immunosuppressive cells and increased activation of T-effector cells within the TME. Cutaneous sensory nerves hindered the maturation of intratumoral high endothelial venules and limited the formation of mature tertiary lymphoid-like structures containing organized clusters of CD4+ T cells and B cells. Denervation further increased T-cell clonality and expanded the B-cell repertoire in the TME. Importantly, CD8a depletion prevented denervation-dependent antitumor effects. Finally, we observed that gene signatures of inflammation and the content of neuron-associated transcripts inversely correlated in human primary cutaneous melanomas, with the latter representing a negative prognostic marker of patient overall survival. Our results suggest that tumor-associated sensory neurons negatively regulate the development of protective antitumor immune responses within the TME, thereby defining a novel target for therapeutic intervention in the melanoma setting.
Towards an Amicable Solution: The Inter-State Communications Procedure under ICERD
Authors: Eiken Jan , Keane David 
Published: July 2022

Abstract
Articles 11–13 ICERD provide for inter-State communications before the UN Committee on the Elimination of Racial Discrimination. The mechanism was triggered for the first time in 2018, with three inter-State communications – Qatar v. Kingdom of Saudi Arabia, Qatar v. United Arab Emirates and Palestine v. Israel. This article offers a detailed, article-by-article analysis of the ICERD inter-State communications mechanism. It looks back at CERD decision-making under Article 11, which pioneered rules of procedure and practice in inter-State communications before a UN treaty body. It considers the composition of the ad hoc Conciliation Commissions under Article 12. It looks forward to the role of the ad hoc Conciliation Commissions under Article 13 in terms of fact-finding, an amicable solution and recommendations. In conclusion, the potential of the Articles 11–13 mechanism as a global contentious human rights jurisdiction is emphasised.
PI-based composites with high dielectric constant and low loss by filling with self-derived carbon
Authors: Li Ke , Peng Mingyun , Yu Qiyu , Huang Bingliang , Cheng Jie 
Published: July 2022

In this work, we prepared polyimide (PI) composite films by directly filling the matrix with self-derived carbon particles. Without any surface modification layer, these specially made particles were compatible with their parent matrix quite well. For the composite film with 25 wt% filler content, the dielectric constant was 72.5 at 1 MHz at room temperature, and the dielectric loss was only 0.069. The conductivity of the corresponding composite was measured to be below 10−6 Sm−1, and the breakdown strength was 165 MVm−1. In addition, the tensile strength of the composite film was measured to be 73 MPa. These results indicate that carbonized PI can be used as an excellent filler to prepare PI-based composite films with high dielectric constant.
Comparing cancer genetic counselling using telegenetics with in-person and telephone appointments: Results of a partially randomised patient-preference pilot study
Authors: Gonzalez Tina , Tucker Kathy , Wakefield Claire E , Geelan-Small Peter , Macmillan Stephanie , Taylor Natalie , Williams Rachel 
Published: July 2022

Introduction Direct-to-patient telegenetics, which uses video conferencing to connect health professionals directly to patients’ devices, has been widely adopted during the pandemic. However, limited evidence currently supports its use in cancer genetic counselling. Methods Before the pandemic, we conducted a two-arm partially randomised patient-preference pilot trial to evaluate direct-to-patient telegenetics for patients and genetic counsellors. Patients were randomised to a standard care (telephone/in-person) or direct-to-patient telegenetics appointment. Patients completed questionnaires before, during and after appointments measuring: psychological distress, perceived genetic counsellor empathy, telegenetics satisfaction and technical challenges. Genetic counsellor-reported outcomes –measured using purpose-designed questionnaires– included telegenetics satisfaction, therapeutic alliance and time for assessment. Open-ended patient and genetic counsellor questionnaire responses were synthesised using content analysis. Results Fifty-six patients and seven genetic counsellors participated. Thirteen patients switched appointment type. No significant differences in distress ( P  =  0.84) were identified between direct-to-patient telegenetics and standard care. Perceived genetic counsellor empathy was high for all appointment types. There was no evidence of differences in reported maximum empathy scores between direct-to-patient telegenetics and standard care [telephone ( P  =  0.57); in-person ( P  =  0.44)]. Patients reported high direct-to-patient telegenetics satisfaction despite technical challenges in most appointments (65%). Genetic counsellors were satisfied with direct-to-patient telegenetics and perceived high therapeutic alliance irrespective of appointment type. No significant differences in genetic counsellor time were identified between direct-to-patient telegenetics and standard care [telephone ( P > 0.90); in-person ( P  =  0.35)]. Discussion Our results suggest that direct-to-patient telegenetics is a satisfactory service delivery model that does not appear to compromise patient–genetic counsellor relationships or increase patient distress. These findings support direct-to-patient telegenetics use in cancer genetic counselling, although larger trials are needed.
The quality of recovery after erector spinae plane block in patients undergoing breast surgery: a randomized controlled trial
Authors: Wiech Marcin , Piwowarczyk Paweł , Mieszkowski Marcin , Tuyakov Bułat , Pituch-Sala Karolina , Czarnik Tomasz , Kurylcio Andrzej , Czuczwar Mirosław , Borys Michał 
Published: July 2022

Abstract
Background
The erector spinae plane (ESP) block has recently been shown to effectively alleviate postoperative pain and reduce opioid consumption in breast surgery patients. However, data are still limited concerning the quality of recovery in patients following this procedure.

Methods
This study was a randomized controlled trial (RCT) performed in a university hospital. We randomly allocated patients to one of three groups: ESP, SHAM, and control (CON). Procedures in the ESP and SHAM blocks were performed ipsilaterally with 0.375% ropivacaine or 0.9% saline (0.4 mL/kg). Our primary outcome was the assessment of the patient’s improvement with quality-of-recovery 40 (QoR-40) a day after surgery. Other outcome assessments included postoperative pain evaluation on the visual analog scale (VAS), 24-hour opioid consumption with patient-controlled analgesia (PCA), time to the first opioid demand, and global satisfaction with perioperative treatment.

Results
Overall, patients in the ESP group had improved QoR-40 compared to the CON group, 186 [177–193] vs. 175 [165–183] (medians and interquartile ranges). Pain severity was significantly higher in the CON group compared to the ESP group at hours 2 (38 [23–53] vs. 20 [7–32]) and 4 (30 [18–51] vs. 19 [7–25]). Moreover, we observed lower oxycodone consumption after 24 hours with the PCA pump between the ESP (4 [2–8] mg) and the CON (9.5 [5–19]) groups. Patients in the CON group used PCA sooner than those in the ESP group. Participants in the ESP group were more satisfied with treatment than those in the CON group. We found no statistical difference between SHAM and the other groups.

Conclusions
Compared to the CON group, the ESP block improved the quality of recovery, alleviated pain intensity, and lowered opioid consumption in patients undergoing breast surgery. However, we did not observe this superiority in comparison with the SHAM group.

Trial registration
NCT04726878.
Application of an innovative grid-based surveillance strategy to ensure elimination and prevent reintroduction of malaria in high-risk border communities in China
Authors: Lu Shen-ning , Ding Wei , Wang Jia-zhi , Yin Shou-qin , Li Sheng-guo , Zhou Xing-wu , Xu Qiu-li , Sun Xiao-dong , Cotter Chris , Hsiang Michelle S , Tatarsky Allison , Gosling Roly , Lv Shan , Wang Duo-quan 
Published: July 2022

AbstractGrid management is a grassroots governance strategy widely implemented in China since 2004 to improve the government’s efficiency to actively find and solve problems among populated regions. A grid-based strategy surveillancing high-risk groups, including mobile and migrant populations (MMPs), in the China–Myanmar border region has played an indispensable role in promoting and consolidating the malaria elimination efforts by tracking and timely identification of potential importation or re-establishment of malaria among MMPs. A sequential mixed methods was implementated to explore the operational mechanism and best practices of the grid-based strategy including through the focus group discussions (FGDs), comparison of before and after the implementation of a grid-based strategy in the field sites, and data collection from the local health system.This paper distills the implementation mechanism and highlights the role of the grid-based strategy in the elimination and prevention of re-establishment of malaria transmission.
Pancreatic juice outflow in pancreatojejunostomy monitoring with the inter-anastomosis drainage tube; a retrospective observational study
Authors: Shimomura Osamu , Oda Tatsuya , Miyazaki Yoshihiro , Furuya Kinji , Doi Manami , Takahashi Kazuhiro , Kim Jaejeong , Moue Shoko , Owada Yohei , Ogawa Koichi , Ohara Yusuke , Akashi Yoshimasa , Enomoto Tsuyoshi , Hashimoto Shinji 
Published: July 2022

Abstract
Background
Pancreatic fistula remains the biggest problem in pancreatic surgery. We have previously reported a new pancreatojejunostomy method using an inter-anastomosis drainage (IAD) suction tube with Blumgart anastomosis for drainage of the pancreatic juice leaking from the branched pancreatic ducts. This study aimed to evaluate the postoperative outcomes of our novel method, in pancreatojejunostomy and investigate the nature of the inter-anastomosis space between jejunal wall and pancreas parenchyma.

Methods
This retrospectively study consist of 282 pancreatoduodenectomy cases, including 86 reconstructions via the Blumgart method plus IAD (B + IAD group) and 196 cases reconstructed using the Blumgart method alone (B group). Postoperative outcomes and the amylase value and the volume of the drainage fluids were compared between the two groups. The IAD tube was placed to collect amylase-rich fluid from the inter-anastomosis space during operative procedure between the jejunal wall and pancreatic stump.

Results
The daily IAD drainage volume and the amylase level was significantly higher in patients with a soft pancreas (vs hard pancreas; 16.5 vs. 10.0 mL/day, p = 0.012; 90,900 vs. 1634 IU/L, p < 0.001, respectively). The mean amylase value of IAD collection in 86 cases of B + IAD group was 63,100 IU/L. The incidence of clinically relevant pancreatic fistula grade B and C (23.2% vs. 23.0%, p = 0.55) and the hospital stay was similar between the groups (median 17 vs. 18 days, p = 0.55). In 176 patients with soft pancreas, the incidence of pancreatic fistula grade B and C (33.3% vs. 35.3%, p = 0.67) and the hospital stay was also similar between the groups (median 22.5 vs. 21 days, p = 0.81).

Conclusions
Positive effect of the IAD method observed in the pilot cases was not reproduced in the current study. IAD tube objectively demonstrated the existence of amylase-rich discharge at the anastomosis site, and countermeasures to eliminate this liquid are highly desired for preventing pancreatic fistula, especially in patients with soft pancreatic texture.
Trial registration Retrospectively registered
Aromatherapy with single essential oils can significantly improve the sleep quality of cancer patients: a meta-analysis
Authors: Cheng Hui , Lin Lu , Wang Shaotong , Zhang Yueyue , Liu Tingting , Yuan Yang , Chen Qiuyun , Tian Li 
Published: July 2022

Abstract
Objective
To investigate the effect of aromatherapy on sleep quality in cancer patients.

Methods
Published literature on the effect of aromatherapy in cancer patients with sleep disorders in the form of randomized controlled trials (RCTs) were systematically retrieved and screened from PubMed, Cochrane Library, Embase, CBM, CNKI, VIP, and Wanfang databases from inception to November 2021. The methodological quality of the included studies was critically and independently evaluated by two reviewers using the Cochrane Risk of Bias Assessment Tool for RCTs. The correlated data were extracted using the pre-designed form, and all analyses were performed using Reviewer Manager version 5.4. Due to the difference in sleep quality instruments, the data extracted in this study were in the form of standard mean difference (SMD).

Results
Ten RCTs included 933 patients (experimental group: 474, control group: 459), and the risk of bias in the included studies was moderate. Aromatherapy could significantly improve the sleep quality of cancer patients [SMD = − 0.79, 95% CI (− 0.93, − 0.66), p < 0.01], especially those with breast cancer [SMD = − 0.98, 95% CI (− 1.57, − 0.40), p < 0.01]. Aromatherapy with single essential oil had a better effect on sleep quality [SMD = -0.94, 95%CI (− 1.25, − 0.62), p < 0.01], of which lavender essential oil had the best effect [SMD = -1.06,95%CI (− 1.49, − 0.63), p < 0.01] while compound essential oils had no effect on sleep quality improvement in cancer patients [SMD = -0.21, 95%CI (− 0.57, 0.14), p = 0.23]. Four of the ten RCTs reported the occurrence of adverse events, of which only one RCT indicated that patients had headache and sneezing while the remaining six did not.

Conclusions
This meta-analysis of 10 RCTs reveals that aromatherapy with single essential oil had a substantial effect on the sleep quality of cancer patients and should be recommended as a beneficial complementary therapy to promote sleep quality in cancer patients.