bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of process variables on adhesion of acrylonitrile butadiene styrene and carbon fiber reinforced acrylonitrile butadiene styrene materials printed using additive manufacturing
Authors: K Vigneshwaran , N Venkateshwaran , Kakur Naresh 
Published: August 2022

Additive manufacturing has the capacity to manufacture functional parts with complicated geometries, fused filament fabrication is a viable additive manufacturing method and an alternative to standard processes for the creation of polymer and fiber-reinforced polymer composites. The influence of process parameters such as layer thickness, infill density, and infill pattern on the interlaminar bonding performance of three-dimensional printed composites was examined in this study. Due to the existence of high porosity and inadequate layer to layer bond, interlaminar shear strength values increase as layer height increases from 0.15 mm to 0.2 mm and decrease by 0.3 mm. The specimens were also subjected to a wettability test to determine the printed material’s adhesive behavior. Scanning electron microscope was used to perform fractography analysis, and fractured specimens were seen. The test findings revealed that carbon fiber reinforced ABS specimens have good interlaminar shear strength and layer adhesive. When comparing carbon fiber reinforced ABS specimens to ABS specimens, the test results demonstrated that interlaminar shear strength and good adhesion between the layers are attained in carbon fiber reinforced ABS specimens.
Multitarget therapy versus monotherapy as induction treatment for lupus nephritis: A meta-analysis of randomized controlled trials
Authors: Lee Young Ho , Song Gwan Gyu 
Published: August 2022

Aim The safety of multitarget treatments is of concern. This study aimed to evaluate the effectiveness and safety of multitarget therapy as an induction treatment for lupus nephritis in comparison with monotherapy. Methods This study included randomized controlled trials (RCTs) that evaluated the effectiveness and safety of multitarget therapies, such as voclosporin+mycophenolate mofetil (MMF), tacrolimus+MMF, or belimumab+standard of care in comparison with MMF or cyclophosphamide (CYC) monotherapy for induction treatment of lupus nephritis. We performed a meta-analysis of the efficacy and safety of multitarget therapy as an induction treatment for lupus nephritis in comparison with monotherapy Results Six RCTs, including 1,437 participants, met the inclusion criteria. The complete remission rate was significantly higher in the multitarget therapy group than in the monotherapy group (odds ratio, 2.155; 95% CI, 1.695–2.739; p < 0.001). Subgroup analysis revealed that the complete remission rate was significantly higher in both tacrolimus+MMF and voclosporin+MMF groups as well as the belimumab+standard of care (SOC) than in the monotherapy or SOC group. The incidence of adverse events did not differ between the multitarget therapy and monotherapy groups. However, cases of infection and pneumonia were numerically higher in the multitarget therapy group than in the monotherapy group. In addition, the incidence of menstrual disorder was significantly lower in the tacrolimus+MMF group than in the CYC group, whereas that of new-onset hypertension was considerably higher in the tacrolimus+MMF group than in the CYC group. Conclusions Multitarget therapy showed a higher complete remission rate than monotherapy; however, cases of infection and pneumonia were numerically more elevated in the multitarget therapy group than in the monotherapy group.
Vertical GaN Power MOSFET with Integrated Fin-Shaped Diode for Reverse Conduction
Authors: Sun Tao , Luo Xiaorong , Wei Jie , Yang Kemeng , Deng Siyu , Zhao Zhijia , Jia Yanjiang , Zhang Bo 
Published: August 2022

AbstractA vertical GaN power MOSFET featuring an integrated fin-shaped non-junction diode (FDMOS) is proposed to improve reverse conduction and switching characteristics. Its static and dynamic characteristics are studied and analyzed by Sentaurus TCAD simulation. Compared with the conventional MOSFET (Con. MOS) with a body diode as a freewheeling diode (FWD), the FDMOS uses the integrated fin-shaped diode to reverse conduction, and thus, a low reverse turn-on voltage VON of 0.66 V is achieved, with a decreasing of 77.9%. Moreover, the Qrr of the FDMOS is reduced to 1.36 μC from 1.64 μC of the Con. MOS, without the minority carrier injection. The gate charge (QGD) of the FDMOS is significantly reduced because the fin structure reduces the gate area and transforms some part of CGD to CGS, and thus, a low switching loss is realized. The QGD, the turn-on loss (Eon) and the turn-off loss (Eoff) of the FDMOS are decreased by 56.8%, 33.8% and 53.8%, respectively, compared with those of the Con. MOS. In addition, the FDMOS is beneficial to reduce the parasitic inductance and the total chip area compared with the conventional method of using an externally connected Schottky diode as an FWD.
Proteomics-based evaluation of the mechanism underlying vascular injury via DNA interstrand crosslinks, glutathione perturbation, mitogen-activated protein kinase, and Wnt and ErbB signaling pathways induced by crotonaldehyde
Authors: Xie Ming-Zhang , Liu Jun-Li , Gao Qing-Zu , Bo De-Ying , Wang Lei , Zhou Xiao-Chun , Zhao Meng-Meng , Zhang Yu-Chao , Zhang Yu-Jing , Zhao Guo-An , Jiao Lu-Yang 
Published: August 2022

AbstractCrotonaldehyde (CRA)—one of the major environmental pollutants from tobacco smoke and industrial pollution—is associated with vascular injury (VI). We used proteomics to systematically characterize the presently unclear molecular mechanism of VI and to identify new related targets or signaling pathways after exposure to CRA. Cell survival assays were used to assess DNA damage, whereas oxidative stress was determined using colorimetric assays and by quantitative fluorescence study; additionally, cyclooxygenase-2, mitogen-activated protein kinase pathways, Wnt3a, β-catenin, phospho-ErbB2, and phospho-ErbB4 were assessed using ELISA. Proteins were quantitated via tandem mass tag-based liquid chromatography-mass spectrometry and bioinformatics analyses, and 34 differentially expressed proteins were confirmed using parallel reaction monitoring, which were defined as new indicators related to the mechanism underlying DNA damage; glutathione perturbation; mitogen-activated protein kinase; and the Wnt and ErbB signaling pathways in VI based on Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and protein–protein interaction network analyses. Parallel reaction monitoring confirmed significant (p < 0.05) upregulation (> 1.5-fold change) of 23 proteins and downregulation (< 0.667-fold change) of 11. The mechanisms of DNA interstrand crosslinks; glutathione perturbation; mitogen-activated protein kinase; cyclooxygenase-2; and the Wnt and ErbB signaling pathways may contribute to VI through their roles in DNA damage, oxidative stress, inflammation, vascular dysfunction, endothelial dysfunction, vascular remodeling, coagulation cascade, and the newly determined signaling pathways. Moreover, the Wnt and ErbB signaling pathways were identified as new disease pathways involved in VI. Taken together, the elucidated underlying mechanisms may help broaden existing understanding of the molecular mechanisms of VI induced by CRA.
Mechanisms of linezolid resistance in Staphylococcus capitis with the novel mutation C2128T in the 23S rRNA gene in China
Authors: Han Xiao , Zou Guiling , Liu Jiaren , Yang Chun , Du Xuefei , Chen Guoyu , Sun Zhe , Zhang Xinyu , Sun Yu , Zhang Wanying , Jiang Xiaofeng 
Published: August 2022

Abstract
Purpose
The objective of this study was to investigate the molecular characteristics and potential resistance mechanisms of linezolid-resistant (LZR) Staphylococcus capitis isolates from a tertiary hospital in China.

Methods
S. capitis isolates were obtained from clinical patient specimens; three of the isolates came from blood cultures and one from the hydrothorax. The agar dilution and E-test methods were used to identify antibiotic resistance. The chloramphenicol-florfenicol resistance (cfr) gene carrier status of the strains was determined by PCR. Whole-genome sequencing (WGS) was used to identify point mutations and L3, L4, and L22 mutations and to study the genetic environment of the cfr gene and the relationships between strains.

Results
The 4 isolates obtained in this study were all linezolid-resistant Staphylococcus strains. A similar of susceptibility profile pattern was observed in all four S. capitis strains, each of which exhibited a multidrug-resistant phenotype. A potentially novel mutation, C2128T, was identified, and the cfr genes of S. capitis strains were all positive. Additionally, the same mutations (C2128T and G2600T) were identified in all 23S rRNA sequences of the isolates, whereas mutations were lacking in the L3, L4, and L22 ribosomal proteins. The genetic environments surrounding cfr were identical in all four isolates. A schematic diagram of the phylogenetic tree showed that they were closely related to AYP1020, CR01, and TW2795, and a total of seven drug resistance genes were identified in these strains.

Conclusions
The study indicated that the resistance of the Staphylococcus capitis strains to linezolid was caused by multiple mechanisms, and a potential novel mutation, C2128T, that may have an impact on bacterial resistance was identified.
Prospective of mycorrhiza and Beauvaria bassiana silica nanoparticles on Gossypium hirsutum L. plants as biocontrol agent against cotton leafworm, Spodoptera littoralis
Authors: Metwally Rabab A. , Azab Hala Sh. , Al-Shannaf Hatem M. , Rabie Gamal H. 
Published: August 2022

AbstractBackgroundPlant-herbivorous insects are a severe danger to the world’s agricultural production of various crops. Insecticides used indiscriminately resulted in habitat destruction due to their high toxicity, as well as disease resistance. In this respect, the development of a sustainable approach to supreme crop production with the least damage is a crucially prerequisite. As a result, the current study was carried out to understand the potential effect of arbuscular mycorrhizal (AM) fungi along withBeauvaria bassianasilica nanoparticles (Si NPs) as a new approach to increase cotton (Gossypium hirsutumL. Merr.) defense against an insect herbivore,Spodoptera littoralis. AM and non-AM cotton plants were infested withS. littoralisand then sprayed with a biopesticide [B. bassianaSi NPs] or a chemical insecticide (Chlorpyrifos).ResultsThe gas chromatography-mass spectrometry (GC–MS) analysis ofB. bassianaSi NPs fungal extract showed that the major constituents identified were Oleyl alcohol, trifluoroacetate, 11-Dodecen-1-AL and 13-Octadecenal, (Z)-(CAS). Besides, results revealed a highly significant decrease in growth parameters inS. littoralisinfested plants, however, with AM fungal inoculation a substantial improvement in growth traits and biochemical parameters such as protein and carbohydrates contents was observed. In addition, stimulation in proline and antioxidant enzymes activity and a decrease in malondialdehyde content were observed after AM inoculation.ConclusionAM fungi mitigate the harmful effects of herbivorous insects by strengthening the cotton plant’s health via enhancing both morphological and biochemical traits that can partially or completely replace the application of chemical insecticides.
Quality of life of patients with coronary heart disease treated with the bioresorbable vascular scaffold (ABSORB™): 2-year results from the GABI-R-registry
Authors: Pahmeier Kathrin , Neusser Silke , Hamm Christian , Kastner Johannes , Wöhrle Jochen , Zahn Ralf , Achenbach Stephan , Mehilli Julinda , Gori Tommaso , Naber Christoph , Nef Holger , Neumann Till , Richardt Gert , Schmermund Axel , Claas Christoph , Riemer Thomas , Biermann-Stallwitz Janine ,   For the GABI-R Study Group
Published: August 2022

Abstract
Background
Numerous studies have reported clinical endpoints following coronary revascularization using bioresorbable vascular scaffolds (BVS), while information about the impact on health-related quality of life is sparse. In this analysis of the German-Austrian ABSORB RegIstRy, the 2 year results concerning quality of life development in a large cohort of patients treated with BVS were reported.

Methods
Data were collected at baseline as well as 30 days, 6 and 24 months after coronary revascularization using BVS. The EQ-5D score, EQ visual analogue scale (VAS) and Seattle Angina Questionnaire (SAQ) were determined for each time point. Patients were categorized according to the indication for coronary revascularization [acute coronary syndrome (ACS), stable angina pectoris (SAP), silent myocardial ischemia (SMI), or other]. Binary logistic regression analysis was performed to determine factors that predict above-average scores two years after implantation.

Results
Data from 1317 patients in 88 centres were included. Reasons for revascularization were: ACS (n = 643), SAP (n = 443), SMI (n = 52), and other (n = 179). Mean EQ-5D was significantly increased after six months, while a value comparable to baseline was found two years after implantation. EQ VAS and four of five dimensions of SAQ were significantly improved over baseline at all follow-up surveys. Particularly strong improvements were seen in SAQ scores angina frequency and quality of life. Binary regressions showed different statistically significant predictors in the respective models.

Conclusions
Following coronary revascularization with BVS strong decrease in self-reported angina frequency and increase of self-reported quality of life were observed with continuous improvements over two years of follow-up.
Trial registration ClinicalTrials.gov Identifier: NCT02066623.
Impact of estimated glucose disposal rate for identifying prevalent ischemic heart disease: findings from a cross-sectional study
Authors: Xuan Jin , Juan Du , Yuyu Niu , Anjing Ji 
Published: August 2022

Abstract
Background
Insulin resistance is one of the major mechanisms for cardiovascular events. Estimated glucose disposal rate(eGDR) has been demonstrated as a simple, accurate, and cost-effective estimator of insulin resistance. Our study aims to evaluate the correlation between eGDR and the prevalent IHD and assess the incremental value of eGDR for identifying prevalent IHD in the rural general population.

Methods
Our study enrolled 10,895 participants from a cross-sectional survey of a metabolic management program. The survey was conducted in the rural areas of southeastern China between October 2019 and April 2020. eGDR = 21.158 − (0.09 * waist circumference) − (3.407 * hypertension) − (0.551 * HbA1c).

Results
The prevalence of IHD was 4.20%. After adjusting for demographic, anthropometric, laboratory, and medical history covariates, each SD increase of eGDR brought a 25.9% risk reduction for prevalent IHD. After dividing eGDR into groups, the top group had a 58.9% risk reduction than the bottom group. Furthermore, smooth curve fitting demonstrated that the correlation between eGDR and prevalent IHD was linear in the whole range of eGDR. Additionally, AUC suggested that eGDR could significantly improve the identification of prevalent IHD by adding it to cardiovascular risk factors (0.703 vs. 0.711, P for comparison = 0.041). Finally, the category-free net reclassification index and integrated discrimination index also implicated the improvement from eGDR to identify prevalent IHD.

Conclusion
Our data demonstrated a significant, negative, and linear correlation between eGDR and prevalent IHD. Our findings could suggest the potential usefulness of eGDR to improve the identification of prevalent IHD in the rural general population.
Restrictions and their reporting in systematic reviews of effectiveness: an observational study
Authors: Helbach Jasmin , Pieper Dawid , Mathes Tim , Rombey Tanja , Zeeb Hajo , Allers Katharina , Hoffmann Falk 
Published: August 2022

Abstract
Background
Restrictions in systematic reviews (SRs) can lead to bias and may affect conclusions. Therefore, it is important to report whether and which restrictions were used. This study aims to examine the use of restrictions regarding language, publication period, and study type, as well as the transparency of reporting in SRs of effectiveness.

Methods
A retrospective observational study was conducted with a random sample of 535 SRs of effectiveness indexed in PubMed between 2000 and 2019. The use of restrictions and their reporting were analysed using descriptive statistics.

Results
Of the total 535 SRs included, four out of every ten (41.3%) lacked information on at least one of the three restrictions considered (language, publication period, or study type). Overall, 14.6% of SRs did not provide information on restrictions regarding publication period, 19.1% regarding study type, and 18.3% regarding language. Of all included SRs, language was restricted in 46.4%, and in more than half of the SRs with restricted language (130/248), it was unclear whether the restriction was applied during either the search or the screening process, or both. The restrictions were justified for publication period in 22.2% of the respective SRs (33/149), study type in 6.5% (28/433), and language in 3.2% (8/248). Differences in reporting were found between countries as well as between Cochrane and non-Cochrane reviews.

Conclusions
This study suggests that there is a lack of transparency in reporting on restrictions in SRs. Authors as well as editors and reviewers should be encouraged to improve the reporting and justification of restrictions to increase the transparency of SRs.
Comparison the effects and side effects of Covid-19 vaccination in patients with inflammatory bowel disease (IBD): a systematic scoping review
Authors: Tabesh Elham , Soheilipour Maryam , Rezaeisadrabadi Mohammad , Zare-Farashbandi Elahe , Mousavi-Roknabadi Razieh Sadat 
Published: August 2022

AbstractCovid-19 is a pandemic disease that is more severe and mortal in people with immunodeficiency, such as those with inflammatory bowel disease (IBD). On the other hand, no definitive treatment has been identified for it and the best way to control it is wide spread vaccination. The aim of this study was to evaluate the benefits and side effects of different vaccines in patients with IBD. Three Electronic databases [Medline (accessed from PubMed), Scopus, Science Direct, and Cochrane] were searched systematically without time limit, using MESH terms and the related keywords in English language. We focused on the research studies on the effect and side effects of Covid-19 vaccination in patients with IBD. Articles were excluded if they were not relevant, or were performed on other patients excerpt patients with IBD. Considering the titles and abstracts, unrelated studies were excluded. The full texts of the remained studies were evaluated by authors, independently. Then, the studies' findings were assessed and reported. Finally, after reading the full text of the remained articles, 15 ones included in data extraction. All included studied were research study, and most of them (12/15) had prospective design. Totally, 8/15 studies were performed in single-center settings. In 8/15 studies, patients with IBD were compared with a control group. The results were summarized the in two categories: (1) the effect of vaccination, and (2) side effects. The effect of vaccination were assessed in 13/15 studies. Side effects of Covid-19 vaccination in patients with IBD were reported in 7/15 studies. Patients with IBD can be advised that vaccination may have limited minor side effects, but it can protect them from the serious complications of Covid-19 and its resulting mortality with a high success rate. They should be also mentioned in booster doses.
Elder abuse in the COVID-19 era based on calls to the National Center on Elder Abuse resource line
Authors: Weissberger Gali H. , Lim Aaron C. , Mosqueda Laura , Schoen Julie , Axelrod Jenna , Nguyen Annie L. , Wilber Kathleen H. , Esquivel Richard S. , Han S. Duke 
Published: August 2022

Abstract
Background
The COVID-19 pandemic has exacerbated circumstances that place older adults at higher risk for abuse, neglect, and exploitation. Identifying characteristics of elder abuse during COVID-19 is critically important. This study characterized and compared elder abuse patterns across two time periods, a one-year period during the pandemic, and a corresponding one-year period prior to the start of the pandemic.

Methods
Contacts (including social media contacts, and email; all referred to as “calls” for expediency) made to the National Center on Elder Abuse (NCEA) resource line were examined for differences in types of reported elder abuse and characteristics of alleged perpetrators prior to the pandemic (Time 1; March 16, 2018 to March 15, 2019) and during the pandemic (Time 2; March 16, 2020 to March 15, 2021). Calls were examined for whether or not abuse was reported, the types of reported elder abuse, including financial, physical, sexual, emotional, and neglect, and characteristics of callers, victims, and alleged perpetrators. Chi-square tests of independence compared frequencies of elder abuse characteristics between time periods.

Results
In Time 1, 1401 calls were received, of which 795 calls (56.7%) described abuse. In Time 2, 1009 calls were received, of which 550 calls (54.5%) described abuse. The difference between time periods in frequency of abuse to non-abuse calls was not significant ($$p=0.28$$

p
=
0.28

). Time periods also did not significantly differ with regard to caller, victim, and perpetrator characteristics. Greater rates of physical abuse ($${\upchi }^{2}=23.52, p<0.001)$$

χ

2

=
23.52
,
p
<
0.001
)

and emotional abuse ($${\upchi }^{2}=7.12, p=0.008)$$

χ

2

=
7.12
,
p
=
0.008
)

were reported during Time 2 after adjustment for multiple comparisons. An increased frequency of multiple forms of abuse was also found in Time 2 compared to Time 1 ($${\upchi }^{2}=23.52, p<0.001)$$

χ

2

=
23.52
,
p
<
0.001
)

.

Conclusions
Findings suggest differences in specific elder abuse subtypes and frequency of co-occurrence between subtypes between time periods, pointing to a potential increase in the severity of elder abuse during COVID-19.