bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors and re-treatment for recurrent lumbar disc herniation after percutaneous endoscopic lumbar discectomy
Authors: Tang Jin , Li Ying , Wu Congjun , Li Xugui , Xie Wei , Lu Qilin 
Published: March 2022

Abstract
Background
Percutaneous endoscopic lumbar discectomy (PELD) has become the most common treatment for lumbar disc herniation (LDH). However, the risk of recurrence after PELD is inevitable. Therefore, clarifying the factors for recurrent LDH is necessary to improve the success rate and reduce the postoperative recurrence rate. The study aimed to investigate the postoperative recurrence rate, factors and re-treatment of recurrent LDH after PELD.
Methods
A total of 685 LDH patients who underwent PELD in our hospital from January 2015 to December 2017 were enrolled in this retrospective study. Postoperative recurrence rate was calculated. Outcomes for re-treatment of recurrent LDH were assessed by comparing VAS and JOA scores before the first surgery, after recurrence and at the final follow-up in patients with recurrent LDH. The factors for recurrent LDH were analyzed by univariate and multivariate analysis.
Results
Recurrent LDH was observed in 23 (3.35%) patients, including 21 cases of ipsilateral recurrent herniation, and 2 cases of contralateral recurrent herniation. Mean recurrence time was 5.4 ± 2.6 months (range, 0.5–11 months). VAS score was decreased, while JOA score was increased at the final follow-up compared with the scores measured before the first surgery and after recurrence. Univariate analysis revealed that body mass index (BMI), the types of disc herniation and postoperative activity levels were correlated with postoperative recurrence, while no correlation was found between sex, age, smoking history, the levels and position of herniated disc and recurrent LDH. Multivariate analysis showed that high BMI, the types of disc herniation (i.e. extrusion, sequestration) and high-intensity postoperative activity levels were risk factors for recurrent LDH.
Conclusions
High BMI, the extrusion and sequestration types of disc herniation, and high-intensity postoperative activity levels may significantly increase the incidence of recurrent LDH. All patients with recurrent LDH had satisfactory results after re-treatment.
Lymphocyte-C reactive protein ratio is a promising indicator for predicting intestinal necrosis in neonates with portal venous gas
Authors: Cao Jian , Zhang Xinyin , Hou Jinfeng , Cui Mengying , Chen Pengfei , Liu Qingshuang , Guo Chunbao , Guo Zhenhua , Wang Yi , Liu Wei 
Published: March 2022

Abstract
Purpose: Portal venous gas (PVG) in neonates is a special abdominal imaging, which often indicates the occurrence of intestinal ischemia and necrosis, and is also an indicator to evaluate the severity and surgical timing of neonatal necrotizing enterocolitis. The timely identification and intervention of intestinal necrosis in neonates with PVG is particularly important, but it is still difficult at present. Various inflammatory factors in predicting prognosis and surgery timing have been described in adult literature, but rarely in neonatal literature. Therefore, we investigate the value of inflammatory factors in predicting intestinal necrosis in neonates with PVG.Methods: We retrospectively reviewed the medical records of neonates with PVG detected by ultrasound in a tertiary-level referral hospital from January 2020 to December 2020. During the study period, 168 neonates with ultrasonographically identified PVG were included and were divided into two groups according to the presence of intestinal necrosis: a necrotic group (n=35) and a non-necrotic group(n=133). We evaluated the predictive values of various combination of inflammatory markers in preoperative period laboratory analyses using the receiver operating characteristic (ROC) method. Results: In the current cohort, a total of 168 patients were identified. Of these, 35 patients (20.8%) underwent intestinal resection due to intestinal necrosis and 5 patients (3.0%) developed intestinal stricture after medical management. The overall survival rate was 164/168 (97.6%). In patients with intestinal necrosis, platelet count (p<0.001), lymphocyte count(p<0.001), Eosinophil count(p<0.001), CRP (C-reactive protein, p<0.001), PLR (platelet–lymphocyte ratio, p=0.002), NLR (neutrophil–lymphocyte ratio, p=0.001), LCR (lymphocyte–CRP ratio, p<0.001) and PCR (platelet- CRP ratio, p<0.001) values were significantly different with those in the patients without intestinal necrosis. Receiver operating characteristic (ROC) analysis results showed that the combination of C-reactive protein levels along with lymphocyte count (LCR) had the highest correlation with intestinal necrosis in neonates with portal venous gas [AUC 0.86 (95% CI 0.79–0.94); p<0.001], with sensitivity of 0.81(0.73–0.87) and specificity of 0.86(0.69–0.95) for the diagnosis of intestinal necrosis. Conclusions: The preoperative LCR score is a promising indicator for predicting intestinal necrosis in neonates with PVG, which could be used as an additional criterion to guide surgical management.
Growth and yield responses of sunflower to drainage in waterlogged saline soil are caused by changes in plant-water relations and ion concentrations in leaves
Authors: Islam Mohammad Nazrul , Bell Richard W. , Barrett-Lennard Edward G. , Maniruzzaman Mohammad 
Published: March 2022

Abstract
Purpose While proper drainage systems could improve crop growth and yield by mitigating waterlogging and salinity stresses, field evidence of the responses in plant-water relations and ion concentrations in leaves is scarce. We investigated the changes in solute potential in soil (Ys), plant-water relations and ion concentrations in leaves of sunflower caused by drainage in waterlogged saline soil, and their impacts on growth and yield. Methods Over two growing seasons, we tested four drainage treatments: undrained, surface drains (SD; 0.1 m deep, 1.8 m apart), subsoil drains (SSD; 0.5 m deep, 4.5 m apart) and SSD+SD. All plots were inundated (2–3 cm depth; ECw 1.5–2.5 dS m–1) for 24 h at vegetative emergence and at 8-leaf stage before opening drains. Results Relative to the most drained treatment (SSD+SD), the undrained treatment caused higher waterlogging at 0–30 cm depth, and decreased Ys of soil at 7.5 cm to 52–374 kPa, leaf K+ by 5–20%, stomatal conductance by 5–37% and leaf greenness by 12–25%, but increased leaf Na+ by 25–70%, Na+/K+ ratio by 38–100% and leaf water potential by 90–250 kPa throughout the cropping season; these changes were closely related with reduced growth and yield. Conclusions The improved yield from the combination of shallow surface and sub-surface drains was attributed to an alleviation of salinity-waterlogging stress early in the season and to increased soil water late in the season that increased Ys and decreased Na+/K+ ratio in leaves.
EQUAL: Improving the Fidelity of Quantum Annealers by Injecting Controlled Perturbations
Authors: Ayanzadeh Ramin , Das Poulami , Tannu Swamit , Qureshi Moinuddin 
Published: March 2022

Abstract
Quantum Annealers (QAs) are single-instruction quantum machines that can only sample from the ground state of an energy function, called Hamiltonian. To execute a program, the problem is cast to a Hamiltonian, embedded on the hardware, and a single quantum machine instruction (QMI) is run. Noise and imperfections in hardware result in sub-optimal solutions on QAs even if the QMI is run for thousands of trials. Owing to the limited programmability of QAs, users execute the same QMI for all trials. This subjects all trials to a similar noise profile throughout the execution, resulting in a systematic bias. We observe that systematic bias leads to sub-optimal solutions and cannot be alleviated by executing more trials or using existing error-mitigation schemes. To address this challenge, we propose EQUAL (Ensemble QUantum AnneaLing). EQUAL generates an ensemble of QMIs by adding controlled perturbations to the program QMI. When executed on the QA, the ensemble of QMIs steers the program away from encountering the same bias during all trials and thus, improves the quality of solutions. Our evaluations using the D-Wave 2000Q machine show that EQUAL bridges the difference between the baseline and the ideal by an average of 14% (and up to 26%), without requiring any additional trials. EQUAL can be combined with existing error mitigation schemes to bridge further the difference between the baseline and ideal by an average of 55% (and up to 68%).
Autophagy-dependent TOR reactivation drives fungal growth in living host rice cells
Authors: Li Gang , Gong Ziwen , Dulal Nawaraj , Rocha Raquel , Wilson Richard 
Published: March 2022

Abstract
The devastating blast fungus Magnaporthe oryzae elaborates invasive hyphae (IH) in living rice cells, separated from host cytoplasm by plant-derived interfacial membranes, but the molecular mechanisms and metabolic strategies (and hence metabolic vulnerabilities) underpinning this fundamental intracellular biotrophic growth phase are poorly understood. Eukaryotic cell growth depends on activated target-of-rapamycin (TOR) kinase signaling, which inhibits autophagy. Here, using live-cell imaging coupled with multiomic approaches, we show how cycles of autophagy in IH modulate TOR reactivation via α-ketoglutarate to support biotrophic growth. Deleting the M. oryzae serine-threonine protein kinase-encoding gene RIM15 abolished the in planta autophagic cycling we describe here in wild type, attenuating biotrophic growth and disrupting interfacial membrane integrity. Δrim15 biotrophic growth was remediated by α-ketoglutarate treatment. Altogether, our results demonstrate that Rim15-dependent cycles of autophagic flux liberate α-ketoglutarate – via glutaminolysis – as an amino acid-sufficiency signal to trigger TOR reactivation and promote biotrophic growth in host rice cells.
First isolation and Genetic characterization of G8P[8] rotavirus strains emerged recently from Guangzhou, China
Authors: Wang Si-Jie , Chen Li-Na , Wang Song-Mei , Zhou Hong-Lu , Qiu Chao , Jiang Baoming , Qiu Tian-Yi , Chen Sheng-Li , Wang Xuan-Yi 
Published: March 2022

Abstract
Background The G[8] genotype rotavirus has been detected frequently in children in many countries and even became the predominant strain in sub-Saharan Africa countries. While there are almost no reports from China. In our study, the whole genome sequences of G8 rotavirus strains in China was reported for the first time, and phylogenetic analysis was performed on them. Methods Virus isolation and subsequent next-generation sequencing were performed for those confirmed G8P[8] specimens. The genetic characteristics and evolutionary relationship were analyzed in comparison with those epidemic rotavirus strains derived from GenBank.Results The two Guangzhou G8 strains were DS-1-like with the closest genetic distance to strains circulating in Southeast Asia, and the VP7 gene of the two strains was derived from human G8 rotavirus instead of animal-derived rotavirus. The large genetic distance indicated that the isolated Guangzhou strains might not be directly introduced from Southeast Asian countries. Instead, it might be produced by reassortment between G8P[8] and other genotype strains circulated in Southeast Asia in recent years. Conclusions This is the first report of the whole genome sequence information of G8 rotavirus strain in China. The clinical and epidemiological significance of these G8 strains in China remains to be further monitored.
Basic Life Support Knowledge in a War-Torn Country: A Survey of Nurses in Yemen
Authors: Alkubati Sameer , Macclean Christopher , Yu Rebecca , Albagawi Bander , Alsaqri Salman , Alsabri Mohammed 
Published: March 2022

Abstract
Background: Successful implementation of Basic life support (BLS) is critical in improving survival rates and outcomes. By extension, health care workers’ knowledge and awareness about BLS is also essential. To our knowledge, there is no available literature pertaining to the level of BLS knowledge of health care professionals in Yemen.Methods: Data was collected for this cross-sectional descriptive study from June to August 2020, using a 10-item questionnaire related to cardiopulmonary resuscitation (CPR) and BLS, along with questions on socio-demographic characteristics. Participants were nurses in public and private hospitals located in Al-Rahida, Taiz governance and Hodeidah, Hodeidah governance in Yemen.Results: Among all completed surveys, 53.65% of answer choices for BLS knowledge were correct and 46.35% of answer choices were incorrect. Having a Diploma was associated with higher survey scores (P < 0.001) compared to having a Bachelor’s degree. Those who said they had ever received training in CPR or received information about CPR had significantly higher scores than those who answered no to these questions (P < 0.001 for both questions).Conclusions: BLS knowledge among nurses in Yemen is comparable to other underdeveloped countries; however, it remains below an acceptable level to ensure maximum survival in the event of cardiac arrest. Future research and efforts should be aimed at implementing strategies to improve BLS knowledge among nurses in Yemen, with a long-term goal of improving BLS knowledge among the non-medical population as well to decrease the burden associated with sudden cardiac death.
Factors Associated With Adherence of Iron Folic Acid Supplementation Among Pregnant Women in Rural Soro District, Hadiya Zone, Ethiopia: Cross Sectional Study
Authors: Arficho Tegegn Tadesse 
Published: March 2022

Abstract
Background: Iron deficiency anemia is a wide spread public health problem around the globe which accounts 20% of maternal death worldwide. World health organization recommends every pregnant woman to take a daily dose of 30-60mg of iron and 400μg of folic acid tablets starting from early months of pregnancy. Despite the advantages of iron and folic acid supplementation the proportion of pregnant women who took iron supplements for 90 days or more during their last pregnancy was very low. Therefore this study assessed the adherence to iron and folic acid supplementation and its associated factors among pregnant women in rural Soro district, Hadiya Zone, Southern Ethiopia. Methods: Cross sectional study was employed to assess the compliance and factors associated with compliance of iron folic acid among women who gave birth one year prior to the date of survey. Simple random sampling method was applied to select the study subjects. Both bivariate and multivariable logistic regression was used to assess the association between the study variables and to control the possible confounding. Results: From the whole study participants only 51(18.8%) women had taken iron folic acid supplements for at least 90 days during their last pregnancy. On multivariable logistic regression analysis after adjusting for potential confounders women who had ANC of 4 and above times were 6.8 times more likely to take the minimum optimum dose of iron folic acid. Women who were frequently visiting health facilities for ante natal care were more likely to adhere for iron folic acid supplements than their counterparts. Conclusion: In this study high proportion of pregnant women did not take adequate dose of iron folic acid tablets during their last pregnancy. Every effort should be done to mobilize pregnant women to take the minimum acceptable dose of IFA during their pregnancy. Additional channels to provide IFA supplements for pregnant women should be considered in addition to providing free IFA tablets ANC contact with mothers.
Analysis of Influencing Factors for Predicting Re-intubation in Patients With Hypoxemia After Extubation: a Retrospective Study Based on the MIMIC-IV Database
Authors: Guo Yafen , Zhu Shouzhen , Duan Xiangjie , Zhang Xueqing , Zhou Quan , Shen Jinhua 
Published: March 2022

Abstract
Purpose: The purpose of this study was to analyze the effects of high-flow nasal cannula (HFNC) and non-invasive ventilation (NIV) on the reintubation and mortality rates in adult patients with hypoxemia, and explore the risk factors for reintubation in these patients.Patients and methods: Clinical data were extracted from the MIMIC IV database. Demographic data, vital signs, laboratory test data, and disease severity scoring systems were collected from the database. The primary and secondary outcomes were defined as the rate of reintubation and mortality at 28 days, respectively. Lasso regression was used to screen for factors influencing reintubation at 28 days in patients with hypoxemia. Receiver operating characteristic (ROC) curves were used to predict reintubation in patients with hypoxemia.Results: In this study, 305 patients received HFNC therapy after extubation, while 234 patients received NIV treatment. Inunivariate analysis, statistically significant differences were identified in terms of respiratory support, paraplegia, sequential organ failure assessment (SOFA) score, overall anxiety severity and impairment scale (OASIS) score, pH, length of stay (LOS) in hospital, LOS in ICU, and serum potassium(p<0.05). In addition, we used lasso analysis and found that age, body mass index, breathing support, oxygenation index, Charlson index, pH, serum potassium, SOFA score, and red blood cell (RBC) count can affect the occurrence of reintubation in patients with hypoxemia. The area under the ROC curves was0.77 (95% confidence interval, 0.70–0.83).Conclusion: The 28-day reintubation and mortality rates were lower inpatients with hypoxemia treated with NIV than in those treated with HFNC. Breathing support, oxygenation index, serum potassium level, SOFA score, and RBC count were factors influencing the 28-day reintubation in patients with hypoxemia.
Persistent Septal Deviation After Septoplasty: Causes and Surgical Management
Authors: Lee Dong-Joo , Jo Hyunju , Kwon Ha-Nee , Park Ji-Hwan , Kim Sung-Dong , Cho Kyu-Sup 
Published: March 2022

Abstract
Purpose: Septoplasty is one of the most common surgical procedures performed by otolaryngologist. There are various causes of persistent septal deviation after primary septoplasty. The purpose of this study was to identify the associated factors affecting the failure of the primary septoplasty, and to investigate operative techniques for correcting residual septal deviation, as well as surgical outcomes. Methods: Seventy-four adult patients underwent revision septoplasty for persistent septal deviation was included. The level of hospital where primary septoplasty was performed, type of septal deviation, persistent deviated septal portion, and techniques used to correct the residual deviation were evaluated. Subjective outcomes using visual analog scale (VAS) and acoustic rhinometry data were assessed. Results: The first septoplasty was performed mainly in primary and secondary hospital. C-shape was more common than S-shape deviation in the anteroposterior and cephalocaudal dimensions. The most common areas of persistent septal deviation were caudal septum (44.6%) followed by multiple sites (20.3%). Correcting techniques included excision of remnant deviated portion (70.3%), septal cartilage traction suture (27.0%), spreader graft (13.5%), and crossing suture (6.8%). There was significant symptomatic improvement in the VAS at 6 months postsurgery. The minimal cross-sectional area and nasal cavity volume of the convex side were significantly increased after revision septoplasty. Conclusion: The patients underwent septoplasty in primary and secondary hospital were more likely to undergo revision septoplasty. Caudal septum was the most common sites of persistent septal deviation. Preoperative careful evaluation for caudal septal deviation characteristics and selection of the appropriate surgical techniques may lead to reduction of the need for revision septoplasty.
Controling average number of photons received per cell to promote the growth of Synechocystis sp. PPC 6803
Authors: Jiangong Zhang , Fan Fei , Yu Tao , Chen Jianpei , Wan Minxi , Li Yuanguang 
Published: March 2022

Abstract
To investigate the actually received light of microalgae cells in the photobioreactor, a light attenuation model of Synechocystis sp. PCC 6803 was established. The relationship between the average number of photons received per cell (APRPC) and the growth of microalgae was analyzed. The results demonstrated, Cornet model was accurately fitted with the light attenuation of Synechocystis sp. PCC 6803 and the cell growth rate was affected by APRPC. A maximum specific growth rate of 0.05 h− 1 was achieved with APRPC from 10− 6 to 4×10− 6 µmol/cell. After 156 h cultivation, compared to two control groups (constant light intensity: 100 and 1800 µmol/(m2·s)), the dry cell weight of the experimental group was higher by 79.1% and 20.0%, respectively. This study indicated that APRAC could be used as a light intensity regulation criterion to improve microalgae production despite different types of reactor and density of microalgae broth, which provided a theoretical basis for improving the biomass yield of Synechocystis sp. PCC 6803 or other microalgae.
Influence of preparation techniques of cellulose II nanocrystals as reinforcement for tannery solid waste-based gelatin composite films
Authors: Muralidharan Vimudha , Gochhayat Saiprasad , Palanivel Saravanan , Madhan Balaraman 
Published: March 2022

Abstract
Herein, the leather waste-based gelatin composite film reinforced with cellulose II nanocrystal (CNC II) extracted from wet wipes using three different hydrolysis techniques is explored for its functional properties. CNC II isolated using peroxide (PCNC), citric acid (CCNC) and hydrochloric acid (HCNC) differed in morphological and crystalline character as investigated using DLS, FE-SEM, FTIR and XRD analysis. The crystallinity of PCNC, CCNC and HCNC was found to be 81.1%, 75.4%, and 86.1%, respectively. The highly crystalline CNC II (PCNC) incorporation improved mechanical stiffness of raw hide trimming waste-based gelatin films by 50% compared to control gelatin film. Maximum thermal stability with T max of 329 ºC was obtained for gelatin films with PCNC nano-reinforcement. Strong interfacial hydrogen bonding interactions between gelatin and cellulose II nanocrystal existed and modified the properties of the film. Incorporation of CNC II reduced the surface wettability of the films and absorbed UV radiation as evidenced by transmittance value T280 of 0.19. Nanocomposite films degraded up to 79.9% of initial mass under 7 days of soil burial. Single use packaging application of garden eggplant seed has been demonstrated.
Monocytosis in the Acute Phase of SARS-CoV-2 Infection Predicts the Presence of Anosognosia for Cognitive Deficits in the Chronic Phase
Authors: Nuber-Champier Anthony , Voruz Philippe , de Alcântara Isabele Jacot , Breville Gautier , Allali Gilles , Lalive Patrice. H , Assal Frédéric , Péron Julie Anne 
Published: March 2022

Abstract
Altered awareness of neuropsychological disorders (i.e., anosognosia) is a striking symptom of post-COVID-19 syndrome. Some leukocytes markers in the acute phase might predict the presence of anosognosia in the chronic phase, but they have not been identified yet. This study aims to determine whether patients with anosognosia for their memory deficits in the chronic phase present specific leukocytes distribution in the acute phase, and if so, whether these leukocytes parameters could predict this anosognosia. First, we compare the acute immunological data of the leukocytes distribution of 20 patients infected with SARS-Cov-2 who displayed anosognosia 69 months after SARS-Cov-2 infection (230.25 ± 46.65 days) versus 41 patients infected with SARS-Cov-2 without developing anosognosia. Second, we performed a ROC analysis to evaluate the predictive value of the leukocytes markers that emerged from this comparison. Blood circulating monocytes (%) at the acute phase of SARS-CoV2 infection is associated with long term post-COVID-19 anosognosia. Finally, serology on admission showing a percentage rate of monocytes of 7.35% of the total number of leukocytes, seems to predict the presence of chronic anosognosia for 6–9 months after infection.