bluuebunny/crossref_metadata_2025_split huggingface dataset:
A nomogram to predict the success rate of patients with small bowel obstruction relief by ileus tube.
Authors: Chen Qing-Feng , Lin Bin-qiang , Zhang Jun-rong , Xue Chao-rong , Pan Jie , Huang Zheng-yuan , Chen Xian-qiang 
Published: June 2022

Abstract
Purpose
This article investigated patient clinical data to establish a nomogram to predict the success rate of patients with small bowel obstruction relief by ileus tube.
Methods
We identified 210 patients with small bowel obstruction treated with ileus tube (January 2014 to January 2020) from a prospectively collected database. Among them, 117 cases were successfully relieved (Successful group), and 93 cases failed (Failure group).
Results
The Successful group had a higher age and body mass index, as well as a shorter time from obstruction to insertion than the failure group before insertion of the ileus tube. White blood cell, neutrophil, red blood cell distribution width and neutrophil-to-lymphocyte ratio were lower in the successful group after insertion of the ileus tube. In addition, white blood cell, neutrophil, and neutrophil-to-lymphocyte ratio decreased in the successful group after insertion. However, the result was the opposite in the Failure group. The success rate of paralytic ileus was the highest (79.4%). Patients with fecal stone ileus had the most rapid ventilation and defecation times. Multivariate analysis showed that the platelet-change, albumin after insertion, time from obstruction to insertion and obstruction factors were independent factors influencing the success rate of ileus tube insertion. In addition, we established nomograms to predict the success rate of patients with small bowel obstruction relief by ileus tube (C-index = 0.753).
Conclusion
This nomogram can effectively predict whether patients can successfully relieve obstruction by ileus tube, which provides convenience for clinical treatment.
Systemic immune-inflammation index (SII) may be an effective indicator in predicting the left ventricular hypertrophy for patients diagnosed with hypertension
Authors: KARAYİĞİT ORHAN ,   Serdar Nurko&#x00E7, ÇELİK MUHAMMET 
Published: June 2022

Abstract

The development of left ventricular hypertrophy (LVH) induced by hypertension is considered as a poor prognosis for patients. Similarly, high values of the systemic immune-inflammation index (SII) can be a leading cause for the increase of mortality and morbidity in cardiovascular events. Within this context, our study aimed to detect the association of SII with LVH caused by hypertension. The study encompassed 150 clients diagnosed with hypertensive in total, and evaluated them as two separate groups with regard to left ventricular mass index (LVMI), including 56 patients (37.3%) with LVH and 94 patients (62.6%) with non-LVH. The SII values regarding the group with LVH was detected remarkably higher than those of the non-LVH group (p<0.001). Additionally, the SII level of clients with eccentric and concentric hypertrophy was detected higher than those of the normal ventricular geometry and concentric remodeling groups. With regard to curve analysis of the receiver-operating characteristic (ROC), SII values above 869.5 predicted LVH with a sensitivity of 82.1% and specificity of 86.2% (AUC: 0.861; 95%CI: 0.792-0.930; p < 0.001). LVH can be predicted independently through the use of SII in clients diagnosed with hypertension, which may be a simple and easily calculable marker for judging LVH. Moreover, SII can serve as an accurate determinant for the prediction of LVH, in comparison to NLR and PLR.
Magnitude of Adherence to Iron Folic Acid Supplementation and Associated Factors among Pregnant Women’s attending Antenatal care at Tirunesh Beijing General Hospital, Addis Ababa, Ethiopia
Authors: Bekele Ashebir , Alemayehu Belayneh , Gemechu Endalew 
Published: June 2022

Abstract
Background. Pregnant mothers are at high risk of anemia because of significantly increased iron requirements, and adherence to iron folic acid supplementation is one of the main strategies for prevention of anemia. Iron deficiency anemia is the most common nutritional disorder, affecting two billion people worldwide. In Ethiopia, l<1% of pregnant mothers took iron folic acid supplements for the recommended period during their pregnancy. Despite this fact, it often remains unrecognized and unidentified in the study area.Objective. the current study was aimed to assess the magnitude of adherence to iron folic acid supplementation and associated factors among pregnant mothers attending antenatal care at Tirunesh Beijing General Hospital, Addis Ababa, Ethiopia.Methods.An institution based cross-sectional study design was conducted .systematic random sampling were used .Data were collected through face to face interview and analyzed with SPSS version 26. By considering 95% confidence level and P value of < 0.05, binary logistic regression was used to identify factors associated.Result. Adherence to iron folic acid supplementation in the study was 43.7% (95% CI: 40.2%–47%). pregnant mothers knowledge of anemia [AOR = 1.51, 95% CI: (1.26-2.27)], had history of abortion [AOR=0.5, 95% CI: (0.29-0.77)], aged less than 25 years [AOR=0.55, 95% CI: (0.32-1.34)], had still birth [AOR=2.21, 95% CI: (1.13-4.31)], collect greater than 60 Iron tablets per visit [AOR=1.34, 95% CI: (1.01-1.89)], husbands education [AOR=5.32, 95% CI: (1.92-14.74)], had Significant association with Iron and Folic acid Adherence.Conclusion and Recommendation. The magnitude of adherence among pregnant women towards IFA supplementation was 43.7%. Still birth, abortion, knowledge about anemia, aged less than 25 years, husbands’ education and the numbers of tablets collected by pregnant women were factors for adherence to iron folic acid supplementation. Emphasis should be given to those women who have had a bad obstetric history and an adequate supply of IFA tablets to enhance the adherence of pregnant women to IFA supplementation.
Occurrence and Diversity of Barley Yellow Dwarf Virus in Algeria
Authors: Boubetra Souhila , Louanchi Meriem , Lehad Arezki 
Published: June 2022

Abstract
Cereals are prone to viral infections and the economic impact of these has increased in recent years. Among these diseases Barley yellow dwarf (BYD) is one of the most destructive diseases of cereals today. For three consecutive years (2014-2015-2016) surveys were carried out in order to search for BYDV species (BYDV-PAV and BYDV-MAV) as well as other cereal viruses (WSSMV, SBMV and BSMV) in seven regions of Algeria (Algiers, Boumerdes, Tipaza Médéa, Adrar, Khenchla and Batna).Targeted samples were taken from plants of different cereal species (wheat, barley, oats). The sample were analyzed by DAS-ELISA and RT-PCR.The results of the ELISA test showed negative responses for the BYDV-MAV, WSSM, SBMV and BSMV viruses and allowed to demonstrate the presence of BYDV-PAV on barley, durum wheat, soft wheat and oats.Thus this viral species was found in all the cereal regions surveyed (North, South, East and West).07 samples (durum wheat, barley and oats) were sequenced and a phylogenetic analyses performed revealed that the Algerian sequences clustered in group I and group II.
Edible Folic and Folinic acid supplementation promotes myocardial cell survival and anti-apoptotic effects in Aging triple-transgenic Alzheimer's mice heart
Authors: Lin Hung-Jen , Huang Rwei-Fen S , Su Yi-Chen , Chiu Ping-Ling , Chang Yung-Ming , Ju Da-Tong , Kuo Wei-Wen , Huang Chih Yang 
Published: June 2022

Abstract
BackgroundCardiomyocytes undergoing apoptosis have been found in a variety of pathological conditions. Evidence suggests that Alzheimer’s disease (AD) and cardiovascular disease share some risk factors, and persons with AD have a higher risk of incident ischemic heart disease.ObjectivesThis study sought to assess the anti-apoptotic effect and survival enhancement in aged AD mice heart in response to folic acid (FA) and folinic acid (FN). Methods In this study, 16-month-old triple-transgenic (3xTg-AD; PS1M146V, APPS we and tauP301L) late-stage AD mice, were randomly allocated into three groups; AD, AD plus FA, and AD plus FN. Mice were orally fed FA or FN once daily at a dose corresponding to 1.2 mg/kg body weight (BW). After sacrifice, the excised heart tissues were processed, and morphological analyses and TUNEL assays were carried out. Further, Western blot assays were performed to quantify the amount of apoptosis and survival protein expression in the AD group compared to the FA and FS groups.ResultsResults indicated reduced intercellular space and well-maintained cardiac cell morphology in both FA- and FN-treated mouse heart tissue. These were even more pronounced in the FN-treated mice. Moreover, the AD groups had a greater number of TUNEL-positive cardiac cells than the other groups. The Western blotting results showed a greater reduction of FAS/L and C-Caspase-3 in FA-treated mice, but FADD and Caspase-8 were strongly reduced in FN-treated mice. ConclusionCollectively, our results suggest that FA or FN could inhibit heart damage by promoting cardiac cell survival and preventing apoptosis in triple-transgenic late-stage AD aging mice.
Comparison of Iris Claw Phakic Lenses Implant Versus Corneal Laser Techniques in High Myopia. Five Years Follow-up
Authors: CASTRO-LUNA GRACIA , Sánchez-Liñán Noelia , Alaskar Hazem , Pérez-Rueda Antonio 
Published: June 2022

Abstract
Background To evaluate the efficacy and safety of Femto-LASIK, PRK, and Artiflex/Artisan phakic lens implantation in the surgical correction of myopia at three months, one, two, and five years of follow-up. Methods A retrospective study was proposed in patients who underwent Femto-LASIK technique (287 eyes of 171 patients), PRK (245 eyes of 191 patients), and phakic lens implantation (147 patient eyes) between 2010-2011 with a preoperative spheric equivalent greater than -6 diopters. The effectiveness and safety indexes were calculated during follow-up, comparing Femto-LASIK, PRK, and Artiflex/Artisan phakic lens implantation. In addition, a multivariate linear regression model was estimated. Results There were statistically significant differences in effectiveness and safety until five years when comparing Artiflex/Artisan versus PRK and Femto-LASIK (p<0.01). A linear regression model has established whose dependent variable was the UCVA at five years and independent variables were spherical equivalent preop, phakic lens implantation, and PRK. The model explained 30.32% of the patients' visual acuity variability at five years. Conclusions Artiflex/Artisan type phakic lens implantation is an effective, safe, and predictable technique at three months, 1, 2, and 5 years with stable refractive results throughout the follow-up periods compared with PRK surgery and Femto-Lasik. The model presented shows phakic lens surgery increases the UCVA result at five years and surgery with PRK decreases this final result.
Pneumococcal concentration and serotype distribution in preschool children with radiologically confirmed pneumonia compared to healthy controls prior to introduction of pneumococcal vaccination in Zanzibar- an observational study
Authors: Elfving Kristina , Strömberg Lucia Gonzales , Gheravandi Shadi , Andersson Maria , Bachelard Marc , Msellem Mwinyi , Shakely Delér , Trollfors Birger , Nordén Rickard , Mårtensson Andreas , Björkman Anders , Lindh Magnus 
Published: June 2022

Abstract
Background The World Health Organization recommends pneumococcal vaccination (PCV) in the first year of life. We investigated pneumococcal serotypes in children with clinical or radiologically confirmed pneumonia and healthy controls prior to PCV13 vaccine introduction in Zanzibar.Methods Children (n=677) with non-severe acute febrile illness aged 2-59 months presenting to a health centre in Zanzibar, Tanzania April-July 2011 were included. Nasopharyngeal swabs collected at enrolment were analysed by real-time PCR to detect and quantify pneumococcal serotypes in patients (n=648) and in healthy asymptomatic community controls (n=161). Children with clinical signs of pneumonia according to the Integrated Management of Childhood illness guidelines (“IMCI pneumonia”) were subjected to a chest-X-ray. Consolidation on chest X-ray was considered “radiological pneumonia”. ResultsPneumococcal DNA was detected in the nasopharynx of 562/809 (69%) children (70% in patients and 64% in healthy controls), with no significant difference in proportions between patients with or without presence of fever, malnutrition, IMCI pneumonia or radiological pneumonia. The mean pneumococcal concentration was similar in children with and without radiological pneumonia (Ct value 26.3 versus 27.0, respectively, p=0.3115). At least one serotype could be determined in 423 (75%) participants positive for pneumococci of which 33% had multiple serotypes detected. A total of 23 different serotypes were identified. One serotype (19F) was more common in children with fever (86/648, 13%) than in healthy controls (12/161, 7%), (p=0.043). Logistic regression adjusting for age and gender showed that serotype 9A/V (aOR=10.9 (CI: 2.0-60.0, p=0.006) and 14 (aOR=3.9 (CI: 1.4-11.0, p=0.012) were associated with radiological pneumonia. The serotypes included in the PCV13 vaccine were found in 376 (89%) of the 423 serotype positive participants.ConclusionThe PCV13 vaccine introduced in 2012 targets a great majority of the identified serotypes. Infections with multiple serotypes are common. PCR-determined concentrations of pneumococci in nasopharynx were not associated with radiologically confirmed pneumonia.Trial registration Clinicaltrials.gov (NCT01094431)
CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNP export in developing embryos
Authors: Huang Youkui , Gao Bao-Qing , Meng Quan , Yang Liang-Zhong , Ma Xu-Kai , Wu Hao , Pan Yu-Hang , Yang Li , Li Dong , Chen Ling-Ling 
Published: June 2022

Abstract
Understanding gene transcription and mRNA-protein (mRNP) dynamics in single cells during development has been challenging. We report that zygotic microinjection of purified catalytically dead CRISPR-Cas13 (dCas13)-fluorescent proteins and modified guide (g)RNAs allows single- and dual-color tracking of developmentally expressed mRNAs in zebrafish embryos over 15 cell cycles without genetic manipulation. Using this approach, we uncover 1) non-synchronized de novo transcription between inter-alleles; 2) synchronized post-mitotic re-activation in pairs of alleles and daughter cells; 3) transcriptional memory as an extrinsic noise that contributes to synchronized post-mitotic re-activation; 4) rapid dCas13-engaged mRNP movement in the nucleus with a corralled and diffusive motion, but a wide varying range of rate-limiting mRNP export, which can be shortened by Alyref and Nxf1 overexpression. Altogether, this optimized dCas13-based toolkit enables robust spatial-temporal tracking of endogenous mRNAs and uncovers features of transcription and mRNP motion in a multicellular developmental organism.
Globally accessible end-user-friendly prostate cancer risk prediction tools based on contemporary cohorts with heterogeneous missing risk factors
Authors: Neumair Matthias , Kattan Michael W. , Freedland Stephen J. , Haese Alexander , Guerrios-Rivera Lourdes , Hoedt Amanda M. , Liss Michael A. , Leach Robin J. , Boorjian Stephen A. , Cooperberg Matthew R. , Poyet Cedric , Saba Karim , Herkommer Kathleen , Meissner Valentin H. , Vickers Andrew J. , Ankerst Donna P. 
Published: June 2022

Abstract
Background: Missing risk factors, whether random or not measured at all, across different hospitals and patients provide challenges, both for the developers of online clinical risk tools and the patients trying to use such tools. This paper provides a development and end-user solution to the commonly encountered limitations of clinical risk tool based decision making due to missing information.Methods: Six state-of-the-art logistic regression approaches accommodating missing data were compared using prostate cancer data from ten North American and European cohorts from the Prostate Biopsy Collaborative Group (PBCG). An additional large European PBCG cohort was withheld for external validation, where calibration-in-the-large (CIL), calibration curves, and area-underneath-the-receiver-operating characteristic curve (AUC) were evaluated. Ten-fold leave-one-cohort-internal validation further validated the optimal missing data approach.Results: Among 12,703 biopsies from 10 training cohorts, 3,597 (28%) had clinically significant prostate cancer, compared to 1,757 of 5,540 (32%) in the external validation cohort. In external validation, the available cases method that pooled individual patient data containing all risk factors input by an end-user had best CIL, under-predicting risks as percentages by 2.9% on average, and obtained an AUC of 75.7%. Imputation had the worst CIL (-13.3%). The available cases method was further validated as optimal in internal cross-validation and thus used for development of an online risk tool. For end-users of the risk tool, two risk factors were mandatory: serum prostate-specific antigen (PSA) and age, and ten were optional: digital rectal exam, prostate volume, prior negative biopsy, 5-alpha-reductase-inhibitor use, prior PSA screen, African ancestry, Hispanic ethnicity, first-degree prostate-, breast-, and second-degree prostate-cancer family history.Conclusion: Developers of clinical risk prediction tools should optimize use of available data and sources even in the presence of high amounts of missing data and offer options for users with missing risk factors.
Impact of low-level donor-specific anti-HLA antibody on post-transplant clinical outcomes of kidney transplant recipients
Authors: Lee Haeun , Lee Hanbi , Eum Sang Hun , Ko Eun Jeong , Min Ji-Won , Oh Eun-Jee , Yang Chul Woo , Chung Byung Ha 
Published: June 2022

Abstract
This study aimed to investigate the impact of low-level donor-specific HLA antibody (low-DSA) on post-transplant clinical outcomes of kidney transplantation (KT) recipients. We retrospectively reviewed 1,027 cases of KT, including 629 living donor kidney transplantations (LDKTs) and 398 deceased donor kidney transplantations (DDKTs) between 2010 and 2018 in our center. Low-DSA was confirmed by positive Luminex assay and negative crossmatch test. We compared the incidence of biopsy-proven allograft rejection (BPAR), changes in allograft function, allograft survival, patient survival, and post-transplant infections between subgroups according to pre-transplant low-DSA. The incidence of overall BPAR and T-cell mediated rejection did not differ between subgroups. However, antibody-mediated rejection (ABMR) developed more frequently in patients with low-DSA than in those without low-DSA in the total cohort, LDKT, and DDKT. In multivariate analysis, low-DSA was an independent risk factor for ABMR. Its impact was more pronounced in DDKT (Odds ratio [OR]: 10.000, 95% confidence interval [CI]: 2.781–35.960) than in LDKT (OR: 5.210, 95% CI: 2.100-12.924). There were no significant differences in other outcomes according to low-DSA. In conclusion, pre-transplant low-DSA had a significant impact on the development of AMBR, which was more pronounced in DDKT than in LDKT. However, its impact on long-term outcome was not significant.
A Detail Probabilistic Seismic Hazard Analysis of National Capital Territory of Delhi, India
Authors: Mandal H. S. , Jani A. , Mishra O. P. 
Published: June 2022

Abstract
An attempt has been made to carry out a detail seismic hazard analysis of the National Capital Territory of Delhi, India using earthquakes that are occurring at a radial distance of 500km from the center of Delhi including Himalayan sources. Tentatively, this area has been demarcated into five seismic source zones based on the recent past seismic activities and the geological faults. A comprehensive earthquake catalog is prepared and updated using different sources of catalogs like IMD. NCS, USGS, ISC, EMSC, JMA, etc. About 4000 earthquake data are considered in this study whose moment magnitudes are varying between 3.5 to 8.0 and the focal depth varies between 5-300km. The earthquake data showed that about 80% of the earthquake energy is realized from the shallow focal depth and the remaining earthquakes are occurring from beyond 100km focal depth. The seismic hazard parameters are estimated for these five seismic zones using Gutenberg- Richter relationship. GIS-based seven probabilistic seismic hazard maps (PGA) of NCT Delhi are generated using the output result obtained through the state-of-the-art probabilistic seismic hazard analysis(R-CRISS software) for the probability of exceedance at 50%, 20%, 10%, 5%, 2%, 1% and 0.5% at 50 years. For each probability of exceedance, the area of NCT Delhi is broadly demarcated into three levels of hazard zones based on the PGA values. Each zone has represented by a range of PGAs, a hazard curve and design spectra. These results may be useful for earthquake-resistant design and detailing structures, study of soil-structure interactions, soil liquefaction, and earthquake ground motion in the soft soil and soil response analysis in the NCT of Delhi.
Offshore Wind Wakes - the underrated impact on the marine ecosystem
Authors: Daewel Ute , Akhtar Naveed , Christiansen Nils , Schrum Corinna 
Published: June 2022

Abstract
The wind wake effect of offshore wind farms (OWFs) affects the hydrodynamical conditions in the ocean, which has been hypothesized to impact nutrient availability in surface waters and consequently marine primary production. However, this has not clearly been shown so far and little is known about the ecosystem response to wind wakes under the premisses of large OWF clusters. Here we show that the wind wakes of large OWF clusters in the North Sea provoke large scale changes in annual primary production with local changes of up to 10%, which occur not only in the direct vicinity of the OWF clusters but are distributed over a wider region. In addition, we found an increase in sediment biomass in deeper areas of the southern North Sea due to reduced current velocities. Our results show that the ongoing OWF developments can have a substantial impact on the structuring of coastal marine ecosystems.
Ghrelin activates the mesolimbic dopamine system via nitric oxide dependent mechanisms in the ventral tegmental area
Authors: Engel Jörgen A , Pålsson Erik , Vallöf Daniel , Jerlhag Elisabet 
Published: June 2022

Abstract
Besides enhanced feeding, the orexigenic peptide ghrelin activates the mesolimbic dopamine system to cause reward as measured by locomotor stimulation, dopamine release in nucleus accumbens shell (NAcS), and conditioned place preference. Although the ventral tegmental area (VTA) appears to be a central brain region for this ghrelin-reward, the underlying mechanisms within this area are unknown. The findings that the gaseous neurotransmitter nitric oxide (NO) modulate the ghrelin enhanced feeding, led us to hypothesize that ghrelin increases NO levels in the VTA, and thereby stimulates reward-related behaviors. We initially demonstrated that inhibition of NO synthesis the ghrelin-induced activation of the mesolimbic dopamine system We then established that antagonism of downstream signaling of NO in the VTA, namely cGMP, prevents the ability of ghrelin to stimulate the mesolimbic dopamine system. The association of ghrelin to NO was further strengthened by in vivo electrophysiological recordings showing that ghrelin enhances the NO release in the VTA. Besides a GABAB -receptor agonist, known to reduce NO and cGMP, blocks the stimulatory properties of ghrelin. The present series of experiment reveal that ablated NO signaling, through reduced production of NO and/or cGMP, prevents the ability of ghrelin to induced reward-related behaviors.