bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and associated factors for incidental prostate cancer among patients who underwent surgery for benign prostatic hyperplasia: first report from Somalia
Authors: Mohamed Abdikarim Hussein , Abdullahi Ismail Mohamud , Warsame Feysal Farah , Mohamud Hussein Ali 
Published: August 2022

AbstractBackgroundThe incidence rate of incidental prostate cancer (IPC) differs significantly among the reported studies in the relevant literature. There is a scarcity of studies regarding IPC reported from Sub-Saharan African Countries, including Somalia. The present is the first study that evaluates the incidence and associated factors for IPC among patients who had surgery for benign prostatic hyperplasia at a tertiary hospital in Somalia.MethodThis retrospective study reviewed the data of 538 patients with benign prostate hyperplasia, 464 patients who underwent transurethral resection of the prostate (TURP), and 74 patients with open prostatectomy (OP) over 5 years. A binary logistic regression model was used to investigate the association between perioperative factors such as age, prostate volume, total prostate-specific antigen (TPSA) levels, type of surgery, specimen weight, and the finding of IPC.ResultsIPC was detected in 17.6%, 18.3% of TURP, and 13.5% of OP patients (p = 0.002). The mean age of the patients was 71.82 ± 7.4; IPC patients had a significantly higher mean age than the BPH group (74 ± 10.9 vs. 71.3 ± 10.8,p < 0.001). Sixty-two percent of the patients were T1b, while 57.8% had ISUP grade groups 1 and 2. Patients with T1a had significantly higher International Society of Urological Pathology (ISUP) grades 1 and 2 than those with T1b (69.4% in T1a vs. 50.8% in T1b,p < 0.001). Increased age, higher TPSA levels, low prostate volume, and specimen weight were independently associated with the finding of incidental prostate carcinoma (OR 1.978, 95% CI 0.95–1.60,P < 0.04; OR 1.839, 95% CI 0.99–2.02,P < 0.001; OR 1.457, 95% CI 0.7102.99,P < 0.001, OR 0.989, 95% CI 1.07–2.94,P = 0.01). IPC was most commonly managed by active surveillance (54.7%), followed by androgen deprivation therapy in 28.4%. The overall survival rate for a 5-year follow-up in the entire cohort was 79%. The cancer-specific mortality was 8.4%.ConclusionThe study findings revealed a higher incidence and cancer-specific mortality rate of incidental prostate carcinoma. T1b stage, higher ISUP grade, older age, and higher preoperative TPSA were significantly associated with the overall mortality and cancer-specific mortality rate. More than half of the cases were managed by active surveillance, and it is a safe management strategy, particularly in low-income countries like Somalia.
Health care professionals’ understanding of contraindications for physical activity advice in the setting of stem cell transplantation
Authors: Meyer-Schwickerath Corinna , Köppel Maximilian , Kühl Rea , Rivera Janina Bujan , Tsiouris Angeliki , Huber Gerhard , Wiskemann Joachim 
Published: August 2022

Abstract

Purpose
Most patients receiving a hematopoietic stem cell transplantation (HSCT) are able to tolerate and benefit from physical activity (PA). Therefore, it is important that health care professionals (HCPs) advise patients to perform PA before, during, and after transplantation. By understanding which medical conditions and safety issues are associated with the (non-) promotion of PA, concrete actions and interventions can be planned and implemented.

Methods
Physicians (N = 51), nurses (N = 52), and physical therapists (N = 26) participated in a nationwide cross-sectional online survey. HCPs’ understanding of 15 medical conditions as contraindications for PA was assessed. Significant group differences were determined using chi-square analysis.

Results
Acute infection was the only condition which was considered as contraindication by all HCPs (62.7%). Cachexia (78%), having a stoma (91%), or port (96.2%), psychological problems (88.4%), and leukopenia (83.3%) were not considered as contraindications. Six conditions were rated inconsistently between the groups, whereas physicians had the least concerns regarding PA. Physicians with an additional training in PA perceived a platelet count of ≤ 50,000/μl significantly less often as contraindication (p < 0.05).

Conclusion
The large number of potentially-answers especially in nursing staff and physical therapists might reflect caution or uncertainty. There is a clear need for a good multidisciplinary cooperation between all HCPs in order to support patients to confidently engage in PA. Furthermore, education possibilities and evidence-based courses to build knowledge regarding safety concerns should be the standard practice in the setting of HSCT. The investigative nature of the paper indicates that certain trends should be interrogated in a causal-longitudinal design.
The relationship between contact network and energy dissipation in granular materials
Authors: Essayah Abdurrahim , Shire Thomas , Gao Zhiwei 
Published: August 2022

AbstractA micromechanical study of the relationship between contact force networks and energy dissipation is presented. A series of drained triaxial compression tests with different stress paths have been simulated using the discrete element method. Two existing contact force network partitioning methods have been used for analysing the energy dissipation, one based on the average contact force magnitude and the other based on the contribution of contact forces to the global deviator stress. For both methods, energy dissipation in neither the strong nor weak contact networks is negligible. When the average contact force partitioning method is used, over 70% of the energy dissipation occurs in the weak contact network, but the dissipation per sliding contact is higher in the strong contact network because the tangential contact force is higher. When the contact network is partitioned based on the contribution of forces to global deviator stress, more than 60% of the energy dissipation occurs in the strong contact network. A new normal contact force threshold for splitting energy dissipation is identified. Specifically, over 93% of energy dissipation occurs at contacts with a normal contact force below 2 times the average normal contact force. There is very small energy dissipation in contacts with higher normal contact force because there is little particle sliding.
Determining patterns in the composition of dissolved organic matter in fresh waters according to land use and management
Authors: Yates Christopher A. , Johnes Penny J. , Brailsford Francesca L. , Evans Christopher D. , Evershed Richard P. , Glanville Helen C. , Jones Davey L. , Lloyd Charlotte E. M. , Marshall Miles R. , Owen Alun T. 
Published: August 2022

AbstractIn fresh waters, the origins of dissolved organic matter (DOM) have been found to exert a fundamental control on its reactivity, and ultimately, its ecosystem functional role. A detailed understanding of landscape scale factors that control the export of DOM to aquatic ecosystems is, therefore, pivotal if the effects of DOM flux to fresh waters are to be fully understood. In this study we present data from a national sampling campaign across the United Kingdom in which we explore the variability in DOM composition in three broad landscape types defined by similar precipitation, geology, land use and management, hydrology, and nutrient enrichment status. We characterised samples from fifty-one sites, grouping them into one of three major underlying classifications: circumneutral streams underlain by clay and mudstone (referred to as ‘clay’), alkaline streams underlain by Cretaceous Chalk or by Carboniferous or Jurassic Limestone (‘limestone’), and acidic streams in peatland catchments underlain by a range of low permeability lithologies (‘peat’). DOM composition was assessed through organic matter stoichiometry (organic carbon: organic nitrogen; organic carbon: organic phosphorus; C/N(P)DOM) and metrics derived from ultra-violet (UV)/visible spectroscopic analysis of DOM such as specific UV absorption (a254 nm; SUVA254). We found similar SUVA254, C/NDOM and DOM/a254 relationships within classifications, demonstrating that despite a large degree of heterogeneity within environments, catchments with shared environmental character and anthropogenic disturbance export DOM with a similar composition and character. Improving our understanding of DOM characterisation is important to help predict shifts in stream ecosystem function, and ecological responses to enrichment or mitigation efforts and how these may result in species composition shifts and biodiversity loss in freshwater ecosystems.
Optic nerve injury models under varying forces
Authors: Sun Wu , Chao Guojun , Shang Mengqiu , Wu Qiong , Xia Yanting , Wei Qiping , Zhou Jian , Liao Liang 
Published: August 2022

Abstract
Purpose
To explore the pathological changes in optic nerve injury models under varying forces.

Methods
The rats were classified into 4 groups: sham operation (SH), 0.1, 0.3, and 0.5 N. Modeling was performed using the lateral optic nerve pulling method. Seven days after modeling, Brn3a immunofluorescence was used to detect retinal ganglion cell (RGC) number, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining was used to detect RGC apoptosis, and flash visual evoked potential (FVEP) was used to detect the optic nerve function on days 1, 3, and 7 after modeling. In addition, LC3 II and P62 expression levels in retinal tissues were detected by western blotting to observe the changes in autophagy levels.

Results
RGC number decreased 7 d after modeling, and it showed a downward trend with increasing damaging force. The number of apoptotic RGCs in ganglion cell layer in the 0.3 and 0.5 N groups was increased and was higher than that in the 0.1 N group. The difference in FVEP of rats in each group was mainly reflected in the P2 peak latency. LC3 II and P62 expression levels in retinal tissue of 0.3 and 0.5 N groups were higher than those of the SH and 0.1 groups; however, the difference between the 0.1 N and SH groups was not statistically significant.

Conclusion
Precisely controlling the force of the optic nerve clamping injury model is necessary because different forces acting on the optic nerve will lead to differences in the loss of optic neurons, the conduction function of the optic nerve, and autophagy level in retinal tissues.
The impact of cognitive aids on resuscitation performance in in-hospital cardiac arrest scenarios: a systematic review and meta-analysis
Authors: Corazza Francesco , Fiorese Elena , Arpone Marta , Tardini Giacomo , Frigo Anna Chiara , Cheng Adam , Da Dalt Liviana , Bressan Silvia 
Published: August 2022

AbstractDifferent cognitive aids have been recently developed to support the management of cardiac arrest, however, their effectiveness remains barely investigated. We aimed to assess whether clinicians using any cognitive aids compared to no or alternative cognitive aids for in-hospital cardiac arrest (IHCA) scenarios achieve improved resuscitation performance. PubMed, EMBASE, the Cochrane Library, CINAHL and ClinicalTrials.gov were systematically searched to identify studies comparing the management of adult/paediatric IHCA simulated scenarios by health professionals using different or no cognitive aids. Our primary outcomes were adherence to guideline recommendations (overall team performance) and time to critical resuscitation actions. Random-effects model meta-analyses were performed. Of the 4.830 screened studies, 16 (14 adult, 2 paediatric) met inclusion criteria. Meta-analyses of eight eligible adult studies indicated that the use of electronic/paper-based cognitive aids, in comparison with no aid, was significantly associated with better overall resuscitation performance [standard mean difference (SMD) 1.16; 95% confidence interval (CI) 0.64; 1.69; I2 = 79%]. Meta-analyses of the two paediatric studies, showed non-significant improvement of critical actions for resuscitation (adherence to guideline recommended sequence of actions, time to defibrillation, rate of errors in defibrillation, time to start chest compressions), except for significant shorter time to amiodarone administration (SMD − 0.78; 95% CI − 1.39; − 0.18; I2 = 0). To conclude, the use of cognitive aids appears to have benefits in improving the management of simulated adult IHCA scenarios, with potential positive impact on clinical practice. Further paediatric studies are necessary to better assess the impact of cognitive aids on the management of IHCA scenarios.
The bright and dark sides of the Dark Triad traits among senior managers: effects on organizational commitment
Authors: Cesinger Beate , Gundolf Katherine , Hughes Mathew , Khedhaouria Anis , Montani Francesco 
Published: August 2022

AbstractSenior managers play a fundamental role in organizations. They shape organizational strategy and culture, set the mission, including opportunities for new markets, and construct the business models. Their commitment to the organization is vital to organizational performance, yet research on personality traits of senior managers and their commitment to organizations is limited. Drawing on self-affirmation theory, we investigate the consequences of senior managers’ ‘Dark Triad Traits’ (narcissism, psychopathy, and Machiavellianism) for their organizational commitment. We use the three-component model developed by Allen and Meyer (J Occup Psychol 63:1–18, 1990) to distinguish affective, continuance, and normative commitment. Our findings from a dataset of 394 senior French managers collected between 2017 and 2018 show that narcissism positively affects continuance commitment and normative commitment. This study contributes to a neglected stream of research investigating the relationship between Dark Triad traits and organizational commitment; contributes to ‘destigmatizing’ Dark Triad traits, often considered problematic for individuals; and adds to the minimal research currently on manager personality and organizational commitment.
Heuristic pricing rules not requiring knowledge of the price response function
Authors: Gahler Daniel , Hruschka Harald 
Published: August 2022

AbstractHeuristic rules are appropriate, if a decision maker wants to set the price of a new product or of a product, whose past price variation is low, and budget limitations prevent the use of marketing experiments or customer surveys. Whereas such rules are not guaranteed to provide the optimal price, generated profits should be as close as possible to their optimal values. We investigate eleven pricing rules that do not require that a decision maker knows the price response function and its parameters. We consider monopolistic market situations, in which sales depend on the price of the respective product only. A Monte Carlo simulation that is more comprehensive than extant attempts found in the literature, serves to evaluate these rules. The best performing rules either hold price changes between periods constant or make them dependent on the previous absolute price difference. These rules also outperform purely random price setting, which we use as benchmark. On the other hand, rules based on arc elasticities or on a loglinear approximation to sales and prices, turn out to be even worse than random price setting. In the conclusion, we discuss how heuristic pricing rules may be extended to deal with product line pricing, additional marketing variables (e.g., advertising, sales promotion, and sales force) and a duopolistic market situation.
Li2TiO3 Dopant and Phosphate Coating Improve the Electrochemical Performance of LiCoO2 at 3.0–4.6 V
Authors: Shi Baozhao , Feng Jiangli , Liu Jing , Zhou Yanan , Zhang Jinli , Li Wei 
Published: August 2022

AbstractA sol–gel tandem with a solid-phase modification procedure was developed to synthesize Li2TiO3-doped LiCoO2 together with phosphate coatings (denoted as LCO-Ti/P), which possesses excellent high-voltage performance in the range of 3.0–4.6 V. The characterizations of X-ray diffraction, high-resolution transmission electron microscopy, and X-ray photoelectron spectroscopy illustrated that the modified sample LCO-Ti/P had the dopant of monoclinic Li2TiO3 and amorphous Li3PO4 coating layers. LCO-Ti/P has an initial discharge capacity of 211.6 mAh/g at 0.1 C and a retention of 85.7% after 100 cycles at 1 C and 25 ± 1 °C between 3.0 and 4.6 V. Nyquist plots reflect that the charge transfer resistance of LCO-Ti/P after 100 cycles at 1 C is much lower than that of the spent LCO, which benefits Li-ion diffusion. Density functional theory calculations disclose the superior lattice-matching property of major crystal planes for Li2TiO3 and LiCoO2, the lower energy barriers for Li-ion diffusion in Li2TiO3, and the suppressed oxygen release performance resulting from phosphate adsorption. This work provides useful guidance on the rational design of the high-voltage performance of modified LiCoO2 materials in terms of lattice-matching properties aside from the phosphate coating to reduce the energy barriers of Li-ion diffusion and enhance cycling stability.
NO-Donation Increases Visceral Circulation in a Porcine Model of Abdominal Hypertension
Authors: Skoog Per , Seilitz Jenny , Oikonomakis Ioannis , Hörer Tal M. , Nilsson Kristofer F. 
Published: August 2022

AbstractIntraabdominal hypertension (IAH) is negative for outcome after intensive care. Little research has focused on medical intervention to improve visceral circulation during IAH. A nitric oxide (NO)-donor was compared with placebo in 25 pigs; each pig was randomized into three groups: PDNO (NO-donor), Control (placebo), or Sham. IAH was induced by CO2 insufflation to 30 mmHg. Sham group had surgical preparation only. Blood gases, invasive venous and arterial blood pressure, intestinal microcirculation and superior mesenteric blood flow were measured. The PDNO group had significantly increased intestinal microcirculation compared with Controls during IAH (last hour, P = 0.009). The mean arterial pressure and abdominal perfusion pressures (APP) were decreased, and the cardiac index were increased in the PDNO group. Also, systemic and pulmonary vascular resistances were lower in the PDNO group compared with Controls. These experimental findings indicate that NO should be further explored with potential application to improve intestinal microcirculation in IAH patients.
Aeroelastic method to investigate nonlinear elastic wing structures
Authors: Bramsiepe Kjell , Klimmek Thomas , Krüger Wolf-Reiner , Tichy Lorenz 
Published: August 2022

AbstractStiffness directions of wing structures are already part of the optimisation in aircraft design. Aircraft like the A350 XWB and the Boeing 787 mainly consist of such composite material, whose stiffness directions can be optimised. To proceed with this stiffness optimisation, the aim of this work is to modify and optimise also the linear stress-strain relation. On that account, the Hooke’s law is exchanged by a multi-linear formulation to analyse any nonlinear elastic structural technology on wing structures. The wing structures, which are used to investigate the nonlinear behaviour, are deduced from a mid-range and a long-range aircraft configuration. These wings are analysed with an extended beam method and coupled with a VLM solution to calculate the aeroelastical loading. The proposed beam method is capable of analysing any multi-linear wing structure technology. A degressive structural behaviour shows up a good potential to reduce the bending moment which is one of the main drivers of the structural weight.
Augmentation and prediction of wick solar still productivity using artificial neural network integrated with tree–seed algorithm
Authors: Sharshir S. S. , Abd Elaziz M. , Elsheikh A. 
Published: August 2022

AbstractThis study introduces a modified artificial neural network (ANN) model based on the tree–seed algorithm (ANN-TSA) to predict the freshwater yield of conventional and developed wick solar stills. The proposed method depends on improving the performance of the ANN through finding the optimal weights of the neurons (elementary units in an ANN) using the TSA. The use of developed wick solar still (DWSS) with copper basin results in increasing the freshwater productivity by about 50% compared with that of conventional wick solar still (CWSS) with steel basin. Then, the proposed ANN-TSA method is utilized to predict the hourly productivity (HP) of CWSS with steel basin and DWSS with copper basin. The real recorded data of the system were used to train the developed models. The predicted HP results of the CWSS and DWSS using ANN-TSA as well as ANN were compared with the experimental results obtained. The present study proves that ANN-TSA can be used as an effective tool to predict the HP of the CWSS and DWSS better than the ANN based on different statistical criteria (R2, RMSE, MRE, and MAE).
Extension of a coupled mooring–viscous flow solver to account for mooring–joint–multibody interaction in waves
Authors: Jiang Changqing , el Moctar Ould 
Published: August 2022

AbstractTo account for nonlinear wave–structure interaction, mooring dynamics and the associated viscous flow effects, a coupled mooring–viscous flow solver was formerly developed and validated (Jiang et al. in Mar Struct 72:783, 2020a, Validation of a dynamic mooring model coupled with a RANS solver). This paper presents an extension of the coupled mooring–viscous flow solver to solve mooring dynamics interacting with an articulated multibody offshore system. The presently extended solver is verified by comparing the predicted motions of and loads on a moored floating box to those obtained from the formerly validated solver, which was aimed for solving mooring dynamics interacting with a single floating body. The almost identical results obtained from both solvers verify the presently developed multi-module coupling technique for solving the mooring dynamics and articulated multibody dynamics in a coupled manner. Apart from the code comparison and verification, the numerical predictions are also validated against experimental tank measurements both for a single body and an articulated multibody. The good agreements between the numerical predictions and the experimental measurements validate the presently extended solver, where wave-induced body motions together with loads acting on mooring lines and joint connections were examined. Developed as an open-source tool, the extended solver shows a potential of the coupled methodology for analyzing an articulated multibody offshore system, moored with various mooring configurations in extreme sea states, which goes beyond the state of the art.