bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of dietary magnolia bark extract supplementation in finishing pigs on the oxidative stability of meat
Authors: Menci Ruggero , Khelil-Arfa Hajer , Blanchard Alexandra , Biondi Luisa , Bella Marco , Priolo Alessandro , Luciano Giuseppe , Natalello Antonio 
Published: August 2022

Abstract
Background
Magnolia bark extract (MBE) is a natural supplement with antioxidant, anti-inflammatory, and antimicrobial activities. Its properties suggest that the dietary supplementation in livestock could improve the quality of products. Therefore, the aim of this study was to investigate, for the first time, the effect of dietary MBE supplementation (0.33 mg/kg) in finishing pigs on the oxidative stability of meat. Oxidative stability is of paramount importance for pork, as it affects storage, retail, and consumer acceptance. For the purpose, the fatty acid profile, cholesterol, fat-soluble vitamins, antioxidant enzymes (catalase, glutathione peroxidase, and superoxide dismutase), non-enzymatic antioxidant capacity (TEAC, FRAP, and Folin-Ciocalteu assays), color stability, and lipid stability of pork were assessed.

Results
Concerning carcass characteristics, dietary MBE did not affect cold carcass yield, but reduced (P = 0.040) the chilling weight loss. The meat from pigs fed MBE had a lower (P = 0.031) lightness index than the control meat. No effect on intramuscular fat, cholesterol, and fatty acid profile was observed. Dietary MBE did not affect the content of vitamin E (α-tocopherol and γ-tocopherol) in pork, whereas it reduced (P = 0.021) the retinol content. The catalase activity was 18% higher (P = 0.008) in the meat from pigs fed MBE compared with the control group. The MBE supplementation reduced (P = 0.039) by 30% the thiobarbituric acid reactive substances (TBARS) in raw pork over 6 d of aerobic refrigerated storage. Instead, no effect on lipid oxidation was observed in cooked pork. Last, the meat from pigs fed MBE reduced Fe3+-ascorbate catalyzed lipid oxidation in muscle homogenates, with a lower (P = 0.034) TBARS value than the control group after 60 min of incubation.

Conclusions
Dietary MBE supplementation in finishing pigs delayed the lipid oxidation in raw meat. This effect was combined with an increased catalase concentration. These results suggest that dietary MBE could have implications for improving the shelf-life of pork.
Self-medication practices and their characteristics among Iranian university students
Authors: Rahimisadegh Rohaneh , Sharifi Nader , Jahromi Vahid Kohpeima , Zahedi Razieh , Rostayee Zahra , Asadi Razieh 
Published: August 2022

Abstract
Background
Self-medication in students, as educated people, is one of the most important health issues. It is known that inappropriate self-medication is harmful for individuals as it has potential risks, disrupts the drug market and increases the per capita financial drug consumption. Thus, the aim of this study is to investigate the habits related to drug use and the prevalence of self-medication practices among university students.

Methods
This cross-sectional study was conducted in 2021 at Jahrom universities/Iran, using an electronic “self-medication practices and medication habits” questionnaire. A total of 848 students from four healthcare and non-healthcare universities participated in the study.

Results
The prevalence of self-medication among students was 44.8%. The most common medicines used for self-medication included cold remedies and sedatives that were used by 33% of the students. About 47% of students stated that they have used antibiotics without a physician’s prescription. The internet and social networks were the source of information on self-medication in about 40% of students. There was no significant difference in self-medication between medical and non-medical students (OR = 0.865, 95% CI: 0.659–1.134). Self-medication in students with underlying disease was higher than students without underlying disease (OR = 2.8, 95% CI: 1.39–5.60).

Conclusions
Self-medication had a high prevalence among students. The best strategy to reduce or eliminate self-medication is to raise students’ awareness and knowledge about potential risk of self-medication practices.
Corpora amylacea are associated with tau burden and cognitive status in Alzheimer’s disease
Authors: Wander Connor M. , Tsujimoto Tamy Harumy Moraes , Ervin John F. , Wang Chanung , Maranto Spencer M. , Bhat Vanya , Dallmeier Julian D. , Wang Shih-Hsiu Jerry , Lin Feng-Chang , Scott William K. , Holtzman David M. , Cohen Todd J. 
Published: August 2022

AbstractCorpora amylacea (CA) and their murine analogs, periodic acid Schiff (PAS) granules, are age-related, carbohydrate-rich structures that serve as waste repositories for aggregated proteins, damaged cellular organelles, and other cellular debris. The structure, morphology, and suspected functions of CA in the brain imply disease relevance. Despite this, the link between CA and age-related neurodegenerative diseases, particularly Alzheimer’s disease (AD), remains poorly defined. We performed a neuropathological analysis of mouse PAS granules and human CA and correlated these findings with AD progression. Increased PAS granule density was observed in symptomatic tau transgenic mice and APOE knock-in mice. Using a cohort of postmortem AD brain samples, we examined CA in cognitively normal and dementia patients across Braak stages with varying APOE status. We identified a Braak-stage dependent bimodal distribution of CA in the dentate gyrus, with CA accumulating and peaking by Braak stages II–III, then steadily declining with increasing tau burden. Refined analysis revealed an association of CA levels with both cognition and APOE status. Finally, tau was detected in whole CA present in human patient cerebrospinal fluid, highlighting CA-tau as a plausible prodromal AD biomarker. Our study connects hallmarks of the aging brain with the emergence of AD pathology and suggests that CA may act as a compensatory factor that becomes depleted with advancing tau burden.
Collagen wrapping and local platelet-rich fibrin do not improve the survival rates of ACL repair with dynamic intraligamentary stabilization: a retrospective case series after ≥5 years postoperatively
Authors: Eberlein Sophie C. , Rodriguez Vanessa , Hecker Andreas , Schürholz Katharina , Ahmad Sufian S. , Klenke Frank M. 
Published: August 2022

Abstract
Purpose
Anterior cruciate ligament (ACL) repair has been recommended as a treatment principle for ACL tears. Several authors have advocated a potential role for primary repair techniques in the ACL decision tree. However, long-term results have been controversial. This study aims to determine the survival of the primarily repaired ACL after dynamic intraligamentary stabilization (DIS) with and without augmentation.

Methods
Between 2014 and 2019, 102 patients with isolated proximal ACL ruptures underwent DIS repair within 21 days from injury and were available for follow-up either clinically or telephonically after ≥5 years postoperatively. In 45 cases, DIS repair was augmented with collagen fleece wrapping, platelet-rich fibrin (PRF) or both. Failure was defined as traumatic re-rupture or conversion to ACL reconstruction. The patients being available for physical examination underwent a.-p. stability measurement with a KT-1000 device. Functional outcome was measured with the IKDC, Tegner and Lysholm scores. Kaplan-Meier survival analysis, Log-Rank Test and Binominal logistic regression were performed.

Results
After a minimum 5-year follow-up, 71/102 (69.6%) DIS repairs were not re-reptured and clinically and/or subjectively stable. Augmentation did not improve survival rates (p = 0.812). The identified factors influencing failure were a younger age and a pre-injury Tegner activity level of ≥7. 95.7% of those patients with an intact ACL repair had normal or near normal knee function based on the IKDC scoring system.

Conclusions
The 5-year overall survival rate of DIS was 69.6%. Collagen fleece wrapping and local PRF application did not improve survival. Patients not suffering failure of repair demonstrated high satisfaction. Nevertheless, the results are inferior to those of established ACL reconstruction procedures.

Level of evidence
Case series, Level IV.
“Competing personas”: aesthetic labor in the Chinese fitness industry
Authors: Wan Renxue 
Published: August 2022

AbstractGiven the proliferation of lifestyle consumption, industries such as the fields of fitness, fashion, and beauty and makeup have experienced rapid growth in terms of employment numbers, leading to fundamental challenges to working patterns. Based on ethnographic data concerning two fitness clubs in Shanghai collected over 13 months and 35 in-depth interviews with managers, fitness trainers, and customers, this article draws on the concept of aesthetic labor to examine how a “persona,” a combination of an ideal physique and a desirable personality in line with the aesthetic tastes of socioeconomically diverse clientele, is developed through the labor process of the fitness trainer. The author introduces the term “competing personas” to characterize shopfloor politics in the fitness industry. By understanding the process of packaging and selling their bodily, gendered, and affective resources as a “game,” fitness trainers draw symbolic boundaries to distinguish themselves from each other, thereby justifying their aesthetic competencies and self-identities. This article distinguishes three types of personas: advisor, friend, and idol, and these types are characterized by different corporeal and affective strategies. The article reveals how the exercise of agency by both male and female workers in the process of persona-building fuels the symbolic reproduction of class and gender inequalities by naturalizing the domination of an ostensibly legitimate taste.
Blood metabolic and physiological profiles of Bama miniature pigs at different growth stages
Authors: Mo Jiayuan , Lu Yujie , Xing Tianqi , Xu Di , Zhang Kun , Zhang Shuai , Wang Yubin , Yan Gang , Lan Ganqiu , Liang Jing 
Published: August 2022

Abstract
Background
Bama miniature pigs aged between six (6 M) and twelve months (12 M) are usually used in human medical research as laboratory pigs. However, the difference in serum metabolic profiles from 6 to 12 M-old pigs remains unclear. This study aimed to identify the metabolic and physiological profiles present in the blood to further explain changes in Bama miniature pig growth. We collected blood samples from 6 M-, eight-month- (8 M-), ten-month- (10 M-), and 12 M-old healthy Guangxi Bama miniature pigs. A total of 20 blood physiological indices (BPIs) were measured: seven for white blood cells, eight for red blood cells, and five for platelet indices. Liquid chromatography and mass spectrometry-based non-targeted metabolomic approaches were used to analyze the difference in metabolites. The associations between the differences were calculated using Spearman correlations with Benjamini–Hochberg adjustment. The 100 most abundant differential metabolites were selected for analysis of their metabolic profiles.

Results
There were no significant differences in BPIs at different ages, but the mid cell ratio and red blood cell number increased with age. Seven BPIs in Bama miniature pigs were closer to human BPIs than to mouse BPIs. A total of 14 and 25 significant differential metabolites were identified in 6 M vs. 12 M and 8 M vs. 12 M, respectively. In total, 9 and 18 amino acids and their derivatives showed significantly lower concentrations in 6 M- and 8 M-old pigs than in 12 M-old pigs. They were identified as the core significantly different metabolites between the age groups 6 M vs. 12 M and 8 M vs. 12 M. Half of the enriched pathways were the amino acids metabolism pathways. The concentration of six amino acids (dl-tryptophan, phenylacetylglycine, muramic acid, N-acetylornithine, l(−)-pipecolinic acid, and creatine) and their derivatives increased with age. A total of 61 of the top 100 most abundant metabolites were annotated. The metabolic profiles contained 14 amino acids and derivatives, six bile acids and derivatives, 19 fatty acids and derivatives, and 22 others. The concentrations of fatty acids and derivatives were found to be inversely proportional to those of amino acids and derivatives.

Conclusion
These findings suggest high levels of MID cell ratio, red blood count, and amino acids in 12 M-old pigs as indicators for improved body function over time in Bama miniature pigs, similar to those in human development. This makes the pig a more suitable medical model organism than the mouse. The results of this study are limited to the characteristics of blood metabolism in the inbred Bama miniature pigs, and the effects of impacting factors such as breed, age, sex, health status and nutritional level should be considered when studying other pig populations.
Delineating the relationship between maritime insecurity and COVID-19 pandemic on West African maritime trade
Authors: Sackey Anthony Djaba , Lomotey Bernard , Sackey Abigail Dede , Lee Raphael Ofosu-Dua , Teye Abraham Akwetey , Quarcoo Richmond Kennedy , Bansah John 
Published: August 2022

AbstractIn this paper, three steps are made. First, an effort is made to show a consequential effect of maritime insecurity on seafarers and marine professionals; they are at risk of a complicated string of processes that impact their lives. Second, there is the risk to the environment and property. Third, the economic cost of traditional maritime crimes is examined against the potential maritime trade expansion from implementing the African Continental Free Trade Area (AfCFTA). Third, the policy and regulatory measures implemented in the region against piracy are assessed to propose additional measures for improvement. Essentially, the study deploys a case study approach with a three-year field observation over the Gulf of Guinea region and is supported by outcomes of various remote interviews, in addition to online surveys conducted over three months—findings are juxtaposed with the estimated cost of piracy and potential implications for policies driving economic advancement. The results showed inadequate maritime surveillance despite enormous legal frameworks amidst the current structures of regional and international corporations. The piracy cost is high and inevitable as a factor of insurance coverage passed onto end consumers. Response to piracy has been reactionary rather than proactive, as attacks have continued in territorial and offshore areas into 2021. The impact will be visible on AfCFTA post-COVID-19. The study highlights the need for a community-based approach to surveillance modelled after the community policing model currently implemented in Ghana.
A comparative study of Botulinum toxin type A versus conventional oral therapy as a second-line treatment of diabetic neuropathy
Authors: Gaber Dina Elsayed , El Deeb Hany M. 
Published: August 2022

Abstract
Background
Diabetes mellitus is commonly complicated by diabetic peripheral neuropathy. Poor adherence to medication is common in diabetic peripheral neuropathy mainly due to common side effects and poor tolerance to medication. Botulinum toxin A intradermal injection has proved efficacy in cases of diabetic peripheral neuropathy, however there is a need to compare its effect to other lines of treatment. The aim of the study was to compare Botulinum toxin type A versus conventional oral treatment as a second-line treatment of painful diabetic peripheral neuropathy. The current study was a comparative study on 30 patients with type 2 diabetes mellitus. Diabetic peripheral neuropathy was proved by nerve conduction study. All patients were on carbamazepine. Patients were divided randomly into three groups. First group was add-on duloxetine, second group was add-on gabapentin and the third group was injected intradermal with Botulinum toxin A.

Results
Our study showed that Botulinum A intradermal injection, gabapentin and duloxetine add-on therapy decreased the VAS and PSQI over a 12-week study period and this was statistically significant at p < 0.001*. Botulinum A intradermal injection also decreased the mean of PSQ1 from 17.3 ± 1.8 to 10.9 ± 3.1 in 12 weeks constituting the highest decline in PSQ1 among the three groups and this was statistically significant at p < 0.001*.

Conclusion
Botulinum toxin A injection had a comparable if not superior efficacy to duloxetine and gabapentin as a second-line treatment of diabetic peripheral neuropathy.
The impact of effective communication-based care on the childbirth experience and satisfaction among primiparous women: an experimental study
Authors: Shamoradifar Zahra , Asghari-Jafarabadi Mohammad , Nourizadeh Roghaiyeh , Mehrabi Esmat , Areshtanab Hossein Namdar , Shaigan Hoorieh 
Published: August 2022

Abstract
Background
There is insufficient scientific evidence on the effect of communication skills of childbirth care providers on maternal childbirth experience and satisfaction. The present study aimed to determine the effect of communication-based care on the childbirth experience and satisfaction among primiparous women.

Methods
A total of 80 primiparous women participated in this experimental study who were randomly assigned into the intervention and control groups. According to the World Health Organization (WHO) care model, the intervention group received effective communication-based care, and the control group received the routine care. Data were collected using demographic and obstetric questionnaires, Labor Agentry Scale (LAS) and Birth Satisfaction Scale-Revised (BSS-R), and Support and Control in Birth (SCIB) scale applied 12 to 24 h after the intervention.

Results
After controlling the effect of confounding variables, the mean scores of childbirth experience (51.23(1.54) and satisfaction (26.03(0.81) in the intervention group were significantly higher than that in the control group (45.33 (1.54) and 22.66 (0.81) respectively; [adjusted mean difference (AMD) = 5.90, CI = 95%: 1.17 to 10.62, P = 0.01] versus AMD =3.37, CI: 95%: 0.87 to 5.87, P = 0.001].

Conclusion
Eeffective communication-based care improved childbirth experience and satisfaction of primiparous women. Therefore, it is recommended that health-care providers should be trained on the communication skills in the delivery room especially during a vital threatened crises such as the Covid pandemic.
The relationship between disease symptoms and restless legs syndrome in adult attention-deficit hyperactivity disorder without iron deficiency
Authors: Kiraz Seda , Çipil Arif , Ergün Nurbanu 
Published: August 2022

Abstract
Background
This study aimed to investigate the frequency of restless legs syndrome (RLS) and the affecting factors in the attention-deficit hyperactivity disorder (ADHD) group without iron deficiency. Drug-naive ADHD patients were included in the study. Patients without iron deficiency filled out the adult ADHD Self Reporting Scale, the Wender Utah Rating Scale, the Beck Depression Inventory, and the Beck Anxiety Inventory. Scale scores were compared in ADHD patients with and without RLS. Univariate and multivariate binary logistic regression analyses were used to determine the risk factors associated with RLS.

Results
A total of 120 ADHD patients participated in the study; 53 were predominantly inattentive ADHD patients (ADHD-I), and 67 were ADHD combined type (ADHD-C). RLS incidence was found to be 31.6%. ADHD symptoms, anxiety, and depression were found to be significantly more severe in patients with ADHD accompanying RLS. Also, anxiety and the presence of ADHD predicted RLS.

Conclusions
The presence of ADHD and accompanying anxiety was effective on RLS, regardless of iron deficiency. RLS is a comorbidity that frequently accompanies ADHD, and its diagnosis and treatment should not be ignored. This is the first study to investigate the frequency of RLS and accompanying factors by excluding iron deficiency in the ADHD group.
Drug repurposing: re-inventing therapies for cancer without re-entering the development pipeline—a review
Authors: Siddiqui Shafina , Deshmukh Ankita Jaywant , Mudaliar Priyanka , Nalawade Apoorva Jagannath , Iyer Deepak , Aich Jyotirmoi 
Published: August 2022

AbstractWhile majority of the current treatment approaches for cancer remain expensive and are associated with several side effects, development of new treatment modalities takes a significant period of research, time, and expenditure. An alternative novel approach is drug repurposing that focuses on finding new applications for the previously clinically approved drugs. The process of drug repurposing has also been facilitated by current advances in the field of proteomics, genomics, and information computational biology. This approach not only provides cheaper, effective, and potentially safer drugs with less side effects but also increases the processing pace of drug development. In this review, we wish to highlight some recent developments in the area of drug repurposing in cancer with a specific focus on the repurposing potential of anti-psychotic, anti-inflammatory and anti-viral drugs, anti-diabetic, antibacterial, and anti-fungal drugs.
Coexistence of pulmonary hydatid cyst and tuberculosis in a child: a case report
Authors: Haif Assia , Achouri Djelloul , Bougharnout Halima , Chahmana Asma , Bouchareb Fahima , Bendecheche Boubakeur , Soualili Zineddine 
Published: August 2022

Abstract
Background
The echinococcosis and tuberculosis of the lungs are both endemic in Algeria.
The coexistence of echinococcosis and tuberculosis in the same lobe of the lung is exceptional.

Case presentation
A 10-year-old girl was admitted with a history of productive cough, fever, and chest pain.
Chest examination revealed decreased air entry at left lower lobe. Chest X-ray demonstrated a round left lower lobe with an air fluid interface. Chest CT scan with intravenous contrast showed a lingual hydroaeric formation measuring 5×6 cm with a detached membrane image.
A diagnosis of a complicated hydatid disease of the lung was made and the patient was subsequently started on oral albendazole before undergoing exploratory thoracotomy where partial cystectomy and the obliteration of the pericyst cavity. Histopathology was notable for echinococcosis membrane characteristics.
After 2 months, the patient re-presented with complaints of cough, hemoptysis, and dyspnea.
Radiographic images favored repermeabilization of bronchopleural fistulas.
The management was the closing of the bronchial openings.
Histological findings include image characteristic of the echinococcosis and tuberculosis.
The patient continued on albendazole and an anti-tuberculosis regimen, with concurrent functional physiotherapy sessions.
During the following 3-year follow-up, drastic clinical, radiographic, and functional improvement was noted.

Conclusion
Concurrent tuberculosis and echinococcosis infection should be taken into consideration when patients present with persistent bronchopleural fistula in endemic areas.
A multidisciplinary approach of different medical teams facilitates diagnosis and rapid treatment.