bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of schistosoma mansoni transmission in hotspots at the late stage of elimination in Egypt
Authors: Ghazy Ramy M. , Ellakany Walid , Badr Mai M. , Taktak Nehad E.M. , Elhadad Heba , Abdo Sarah M. , Hagag Ayat , Hussein Abdel Rahman , Tahoun Mohamed M. 
Published: July 2022

Abstract
Purpose To investigate the role of human practices and environmental factors in maintaining the transmission chain. Study Design a Cross-section study was conducted between July and November 2019 to determine the effect of malacological and environmental factors on the prevalence of Schistosoma mansoni (S.mansoni) in Kafr El-Sheikh (KES). Methods 2259 fecal samples were collected from 861recruitted children aged 6-15 years. Simultaneously, water and snail samples were collected from watercourses surrounding their houses. Results Prevalence of Schistosoma mansoni infection was significantly higher during summer than during fall (19.1% Vs 7.2%, respectively, p <0.01).The intensity of infection (light, moderate, and heavy) during summer versus fall was (93.55% vs 89.38%, 6.45% vs 8.85, and 0.00% vs 1.77%), P<0.05. Higher prevalence of human infection was identified among males than females (OR=1.63, CI: 1.10-2-40), children aged 11-15 years than among counterparts aged 6-10 years, (OR=2.96), and if mothers were of low educational level (OR=2.83, CI: 1.72-5.06). The main identified risk factors were contacting the main body of water-canal for either washing clothes, land irrigation, collecting waters, bathing, or garbage disposal (P<0.05). The count of collected Biomphalaria alexandrina (B. alexandrina) was statistically different across different seasons (p<0.01) in line with a similar significant difference in water temperature, salinity, turbidity, total coliforms (TC) concentration, depth, velocity, and water level (p<0.01). The presence of grasses and duckweeds had a significant association with snail infection (p = 0.00l). Water depth, pH, temperature, and total dissolved solids (TDS) significantly affected the snail count. Conclusions The persistence of the transmission cycle is mainly affected by the socioeconomic status, and the adopted risky behaviors of the local citizen. Over and above, environmental factors enhance snail survival and catching the cercarial infection.
Predictive-Adaptive Sliding Mode Control Method for Reluctance Actuator Maglev System
Authors: Xu Yunlang , Ding Chenyang , Su Xinyi , Li Zhi , Yang Xiaofeng 
Published: July 2022

Abstract
The control performance of reluctance actuator maglev system is seriously affected by inherent nonlinearities (e.g., hysteresis, eddy current, flux leakage, etc.) and external disturbances. To this end, this paper proposes an enhanced unknown system dynamics estimator (USDE)-based sliding mode control (USDE-SMC) method by a novel predictive-adaptive switching (PAS) controller (USDE-SMC-PAS). First, a USDE is incorporated into SMC to compensate for the uncertainties; Second, an adaptive switching (AS) controller is used to reduce chattering; Finally, the switching controller is modified by PAS to enhance the dynamic response ability and disturbance rejection ability with reduced chattering. In the PAS controller, the switching gain comprises a filtered estimate error part and a residual part, which are obtained by a first-order filter and an adaptive law, respectively. Consequently, the strong disturbance compensation ability, high levitation accuracy, high dynamic response, and reduced chattering property can be achieved simultaneously. The stabilities of USDE-SMC, USDE-SMC with an AS controller (USDE-SMC-AS), and USDE-SMC-PAS in the closed-loop system are analyzed by the Lyapunov theorem. Simulations and experiments are provided to validate the effectiveness and superior performance of the proposed method.
Major Complications and Mortality After Ventral Hernia Repair:An Eleven-Year Swedish Nationwide Cohort Study
Authors: Lindmark Mikael , löwenmark thyra , strigard karin , gunnarsson ulf 
Published: July 2022

Abstract
Background and aims:
Ventral hernia repair is one of the most common surgical procedures performed worldwide. Despite the large volume, consensus is lacking regarding indications for repair or choice of surgical method used for reconstruction. The aim of this study was to explore the risk for major complications and mortality in ventral hernia repair using data from a nationwide patient register.
Method:
Patient data of individuals over 18 years of age who had a ventral hernia procedure between 2004 and 2014 were retrieved from the Patient Register kept by the Swedish National Board of Health and Welfare. After exclusion of patients with concomitant bowel surgery, 45 676 primary surgical admissions were included. Procedures were dichotomised into laparoscopic and open surgery, and stratified for primary and incisional hernias.
Results:
A total of 45 676 admissions were analysed. The material comprised 36% (16 670) incisional hernias and 64% (29 006) primary hernias. Women had a higher risk for reoperation during index admission after primary hernia repair (OR 1,84 (1,29 − 2,62)). Forty-three patients died of complications within 30 days of index surgery. Patients aged 80 years and older had a 2.5 times higher risk for a complication leading to reoperation, and a 12-fold higher mortality risk than patients aged 70–79 years.
Conclusion:
Age is the dominant mortality risk factor in ventral hernia repair. Laparoscopic surgery was associated with a lower risk for reoperation during index admission. Reoperation seems to be a valid outcome variable, while registration of complications is generally poor in this type of cohort.
Minocycline attenuates lipopolysaccharide-induced locomotor deficit and anxiety-like behavior via upregulation of the BDNF/CREB protein expression in the rat medial prefrontal cortex (mPFC)
Authors: Qaid Entesar Yaseen Abdo , Abdullah Zuraidah , Zakaria Rahimah , Long Idris 
Published: July 2022

Abstract
Introduction: Neuroinflammation following lipopolysaccharide (LPS) administration induces locomotor deficit and anxiety-like behavior. In this study, minocycline was compared to memantine, the NMDA receptor antagonist, for its effects on LPS-induced locomotor deficit and anxiety-like behavior in rats. Methodology: Adult male Sprague Dawley rats were administered either two different doses of minocycline (25 or 50 mg/kg/day, i.p.) or 10 mg/kg/day of memantine (i.p.) for 14 days four days prior to LPS (5 mg/kg, i.p.) injection. The locomotor activity and anxiety-like behavior were assessed using the open field test (OFT). The phosphorylated tau protein level was measured using ELISA while the expression and density of brain-derived neurotrophic factor (BDNF) and cAMP response element-binding protein (CREB) protein in the medial prefrontal cortex (mPFC) were measured using immunohistochemistry and western blot, respectively. Results: In the mPFC, minocycline treatment reduced the locomotor deficit and anxiety-like behavior, reduced phosphorylated tau protein level, and upregulated BDNF/CREB protein expression comparable to memantine, with the higher dose of minocycline having better benefits. Conclusion: Minocycline treatment attenuated LPS-induced locomotor deficit and anxiety-like behavior in rats, possibly via a decrease in phosphorylated tau protein levels and an increase in the expression of the BDNF/CREB proteins.
Simulation of Long-period Ground motion: verification and sensitivity study on the 2013 Lushan Mw6.6 earthquake
Authors: Ji Zhiwei , Li Zongchao , Chen Xueliang , Sun Jize , Yu Houyun , Li Tiefei , Li Qi , Huang Ting , Zhang Bo 
Published: July 2022

Abstract
The eastern margin of the Tibetan plateau is adjacent to the Sichuan Basin, which is one of the areas with frequent large earthquakes. The important structures such as bridges and lifeline projects in the region is easily affected by long-period ground motion. It is significant to evaluate the long-period ground motion characteristics of destructive earthquakes in this region. In the first part of this study, the long-period ground motions of the 2013 Lushan Mw6.6 earthquake is simulated using the finite difference method, and three one-dimensional crustal velocity structures are used. We first compared the observed and simulated long-period ground motions of three models in terms of velocity waveforms, pseudo-velocity response spectra, and displacement response spectrum. We then analyzed the residuals of velocity waveforms between the amplitude of simulated and observed. In the second part of this study, the source parameters of rupture velocity, rise time, and stress drop are selected for sensitivity analysis. The results show that it is feasible to use the one-dimensional crustal velocity model of the Sichuan basin to analyze the long-period ground motion of the 2013 Lushan Mw6.6 earthquake. The amplitude of long-period ground motion decreases with the increase of rise time. The amplitude of long-period ground motion and the change of stress drop shows a linear relationship as a whole. The rupture velocity exceeds the shear wave velocity making the PGV distribution of long-period ground motion show spatial variability. In predicting scenario earthquakes, the uncertainty of parameters should be carefully considered. When some parameters are more sensitive to the long-period ground motion, more weights need to be given to these parameters to obtain reliable ground motion results.
The Spatiotemporal Variations of Total Column Ozone Concentration over Ethiopia
Authors: Alemu Abebaw Bizuneh , Seid Abdu Mohammed , Yeshita Baylie Damtie , Raju U. Jaya Prakash 
Published: July 2022

Abstract
We have studied the spatiotemporal characteristics of ozone concentration over Ethiopia using Ozone Mapper and Profiling Suite (OMPS) Satellite measurements. Daily total column ozone measurements of 252 data points with spatial resolution 1 ◦ × 1 ◦ for the study area and its surrounding during the period 2012 – 2020 have been analyzed. We investigated the spatial variation over the region from longitudinal and latitudinal bands separately by assessing existence of mean difference among different bands using multicomparison analysis of variance technique and determined the clusters in the region. For the temporal variability, we employed timeseries analysis and decomposed the ozone concentration series for each class into seasonal, trend and residual components. We have found that the total column ozone concentration has a maximum value of 301DU during summer on August 18, 2013 and a minimum value of 216DU during winter on February 03, 2013 over the study period. The 95% confidence level of the overall mean of total column ozone concentration during the study period was found to be (261 . 28 ± 4 . 2)DU . Our spatial data analysis revealed that the spatial distribution of ozone over Ethiopia can be classified into three major regions: Southern Cluster (4 . 5 ◦ N − 8 . 5 ◦ N & 32 . 5 ◦ E − 47 . 5 ◦ E ) , North–Eastern Cluster (9 . 5 ◦ N to 14 . 5 ◦ N & 41 . 5 ◦ E − 47 . 5 ◦ E ) and North–Western Cluster (9 . 5 ◦ N − 14 . 5 ◦ N & 32 . 5 ◦ E − 40 . 5 ◦ E ). We also checked the degree of determination among bands in same cluster to see if the concentration of ozone in one band can be explained by the concentration in a another band for each cluster and confirmed the reliability of the classification. From the timeseries analysis, we made an assessment of spectral periodogram for each cluster and obtained a single Fourier power peak with frequency of f = 0 . 002768 Hz , which indicated that the ozone concentration has an annual cyclic behavior in the region. A truncated Fourier series fit is made to determine the annual seasonal component. The non-parametric Mann-Kendall’s trend test with a 95% confidence level of significant indicated a decreasing linear trend with a depletion rate of 0.77 DU/yr, 0.73 DU/yr, and 0.43 DU/yr over North–Western, North–Eastern & Southern clusters respectively. The analysis of residuals result for each cluster indicated that the standardized residuals are normally distributed and white noises. Hence, the model considered is reliable.
Tetrahydroquinolinone derivatives exert antiproliferative effect on colorectal and lung cancer cells through apoptosis induction
Authors: Ryczkowska Małgorzata , Maciejewska Natalia , Olszewski Mateusz , Witkowska Milena , Makowiec Sławomir 
Published: July 2022

Abstract
The anticancer properties of quinolones is a topic of interest among researchers in the scientific world. Because these compounds do not cause side effects, unlike the commonly used cytostatics, they are considered a promising source of new anticancer drugs. In this work, we designed a brief synthetic pathway and obtained a series of novel 8-phenyltetrahydroquinolinone derivatives functionalized with benzyl-type moieties at position 3. The compounds were synthesized via classical reactions such as nucleophilic substitution, solvent lysis, and condensation. Biological evaluation revealed that 3-(1-naphthylmethyl)-4-phenyl-5,6,7,8-tetrahydro-1H-quinolin-2-one (4a) exhibited potent cytotoxicity toward colon (HTC-116) and lung (A549) cancer cell lines. Analysis of the mechanism of action of compounds showed that compound 4a induced cell cycle arrest at the sub-G1 phase, leading to apoptotic cell death via intrinsic and extrinsic pathways. Taken together, the findings of the study suggest that tetrahydroquinolinone derivatives bearing a carbonyl group at position 2 could be potential lead compounds to develop anticancer agents for the treatment of colon and lung cancers.
Impact of Power Ramp Event on Photovoltaic System Voltage Quality Under Different Weather Conditions and Operating Powers
Authors: boulahchiche saliha , ARAB Amor HADJ , HADDAD Salim , BOUTELHIG Azzedine , BOUCHAKOUR Salim , BENDAAS Ismail , REZAGUI Abdelhak 
Published: July 2022

Abstract
This paper presents an experimental voltage quality analysis affected by passing clouds based on results attained from monitoring a 9.5-kWp photovoltaic grid connected. This system is composed of three 3.2 kWp subsystems installed on the flat roof of the Renewable Energy Development Institute (CDER) in Algeria. In this paper we analyzed and evaluated Short-term and long-term voltage flicker indexes (Pst,Plt), power ramp event on voltage quality, harmonics caused by inverter and by the loads connected to the PCC, and very short voltage variation (VSV). The power quality parameters at the inverter output side have been measured using CA8335 power quality analyzer. The results show that the change in the density of the passing clouds has a linear relationship with the change in the intensity of the ramp event on the power generated by the PVS. Moreover, in the case of a bidirectional electrical network and with the presence of non-linear loads, the flicker recorded has exceeded the legal limits, due the second-order harmonics effects generated by non-linear loads and the level impedances at the grid and the PV system connection point. The concluded results obtained can be an additional profit of for the electricity distribution networks in Algeria, upon in the light of the diffusion of promoting photovoltaic systems.
circPLIN2 promotes clear cell renal cell carcinoma progression via the miR-199a-3p/ZEB1 pathway
Authors: Zhao Bin , Huang Cong , Pan Jie , Hu Hao , Liu Xiaojuan , Zhang Kaoyuan , Zhou Fenli , Shi Xin , Wu Jun , Yu Bo , Chen Xiaofan , Zhang Wei 
Published: July 2022

Abstract
Recent evidence has indicated that circular RNAs (circRNAs), as a novel type of regulatory RNA, play important roles in the development and progression of various cancers. However, the potential regulatory roles and molecular mechanisms of circRNAs in clear cell renal cell carcinoma (ccRCC) remain largely unclear. Herein, we explored the expression profiles of circRNAs in 10 paired samples of RCC (including cancer tissues and surrounding tissues) from the Gene Expression Omnibus (GEO) datasets GSE124453 and GSE108735. We initially identified hsa_circ_0086457, designated circPLIN2, which was derived from exons 4 to 5 of the PLIN2 gene. circPLIN2 was significantly upregulated in ccRCC cells and tissues, and its overexpression was correlated with higher clinical stage and worse prognosis in ccRCC patients. We observed that circPLIN2 was preferentially located in the cytoplasm and had more stability than its linear counterpart PLIN2. Moreover, gain- and loss-of-function assays demonstrated that elevated circPLIN2 promoted ccRCC cell proliferation, migration and invasion in vitro and ccRCC tumor growth in vivo. Mechanistically, circPLIN2 competitively sponged miR-199a-3p to abolish the repressive effect of miR-199a-3p on ZEB1, which ultimately resulted in tumorigenesis and progression of ccRCC. Collectively, our results suggest that circPLIN2 may serve as a promising diagnostic and prognostic biomarker as well as a potential therapeutic target for ccRCC patients.
A Relay Selection Algorithm Based on User Trust Degree for D2D Communications
Authors: Liu Haoran , Li Xiaobin 
Published: July 2022

Abstract
The emergence of 5G has promoted the rapid development of the Internet of Things(IOT), the dramatic increasing of mobile equipment has led to the increasing shortage of spectrum resources, D2D(Device-to-Device) communication technology is widely concerned for its ability to improve the utilization of spectrum resources. In order to expand the communication scope, relay nodes are introduced into D2D communications, as the third party of D2D relay communication, the quality of relay nodes directly affects the quality of communication process. In order to make more users willing to participate in relay communication, social relationship is introduced into D2D relay communication, However, as an explicit relationship between people, the function of social relationship in D2D communication is limited by the mobility of users and the variability of communication scenarios. In order to find a more reliable relay node and upgrade the connection success rate of D2D relay communication, implicit social relationship between the users need to be mined. Aiming at that, user trust degree (UTD) is established in this paper. By combining the explicit relationship which is called the social connectivity degree with the implicit social relationship called the interest similarity degree, and considering the user’s movement, a relay selection algorithm is presented to help sender find a relay node with a deeper user trust, which can increase the user’s willingness to participate in D2D relay communication and upgrade the success rate of communication connection, so this algorithm can ensure the security of the relay node and can improve the throughput performance. Simulation results show that this algorithm can increase the success rate of connection, improve the overall throughput of the system and improve the user's communication experience.
Urinary soluble CD163: a non-invasive biomarker to monitor lupus nephritis
Authors: Toumi Eya , Jourde-Chiche Noémie , Tailliar Maxence , Mezouar Soraya , Bouamri Afaf , Bertin Daniel , Militello Muriel , Penaranda Guillaume , Plauzolles Anne , Halfon Philippe , Mege Jean-Louis , Bardin Nathalie 
Published: July 2022

Abstract
Due to the role of macrophages in glomerular inflammation, macrophage surface molecules such as CD163 and CD11b represent attractive biomarkers for monitoring Lupus Nephritis (LN). We hypothesize that their urinary levels may reflect kidney disease activity. Here, we first analyzed the levels of urinary soluble CD163 (U-sCD163) and CD11b (U-sCD11b) in a cohort of 40 patients with LN including 23 with active disease. U-sCD163 levels were significantly elevated in active LN and correlated with the renal activity score, in contrast to U-sCD11b. Then, we developed the pristane induced LN mouse model to analyze, in a longitudinal way, the evolution of U-sCD163 levels according to the glomerular inflammation progression and response to treatment. We showed an increase of U-sCD163 levels associated with glomerular immune-complex deposits on mouse kidney biopsies at an early stage of the disease and a correlation with inflammatory markers including interferon-α, C-reactive protein and tumor necrosis factor-α. In addition, we showed that U-sCD163 levels decreased following efficient hydroxychloroquine treatment. Altogether our results led us to conclude that U-sCD163 represent a non-invasive biomarker for LN reflecting glomerular inflammation. Although prospective study in patients with LN, active or not, are necessary, U-sCD163 could be proposed to monitor response to treatment.
Extrauterine growth restriction in very low birth weight infants according to different growth charts: a retrospective 10 years observational study
Authors: Starc Meta , Giangreco Manuela , Centomo Giacomo , Travan Laura , Bua Jenny 
Published: July 2022

Abstract
Background
Extrauterine growth restriction (EUGR) is common among very low birth weight (VLBW) infants and associated with poor neurodevelopmental outcomes. Prevalence of EUGR is a basic indicator of ‘nutritional care’ and an important health outcome measure. There are two types of EUGR definitions (cross-sectional and longitudinal) and many growth charts for monitoring postnatal growth. Aims of our study were 1) to compare the rate of small for gestational rate (SGA) and EUGR in a population of VLBW infants, both according to different growth charts (Fenton, INeS charts and Intergrowth-21) and according to different definitions; 2) to identify risk factors for EUGR.
Methods
this is a single centre retrospective observational study, including all VLBW infants born between 1st of January 2009 and 31st of December 2018. Anthropometric measures were obtained at birth and at discharge and presented as z-scores according to three growth charts (Fenton, INeS charts, Intergrowth-21). Maternal, clinical and nutritional data were retrieved from clinical records.
Results
228 VLBW were included. Percentage of SGA did not change significantly according to the three different growth charts (Fenton 22.4%, INeS charts 22.8%, Intergrowth 28.2%, p 0.27). Prevalence of EUGR was significatively higher when INeS and Fenton charts were used, compared to Intergrowth charts regardless of EUGR-definition (cross sectional-EUGR: Fenton 33.5%, INeS charts 40.9%, Intergrowth-21 23.8%, p 0.001; longitudinal-EUGR (loss of 1SDS): Fenton 15%, INeS charts 20.4%, Intergrowth 4%, p < 0.001). In our population late-onset-sepsis increased the risk of longitudinal EUGR (OR: 2.69, 95%CI: 0.79–9.17), similarly as a longer time to reach 100 ml/kg of feeds (OR: 1.12, 95%CI: 0.97–1.29). On the contrary, preeclampsia was a protective factor for longitudinal EUGR.
Conclusions
We confirmed a wide variability of EUGR rates when using different charts and definitions, highlighting that Intergrowth-21 charts identify less EUGR when compared to INeS and Fenton charts. Standardized criteria for defining EUGR are warranted in order to facilitate comparisons between studies and to improve the nutritional management of VLBW infants.