bluuebunny/crossref_metadata_2025_split huggingface dataset:
DNA‐Tetrahedra Corona‐Modified Hydrogel Microcapsules: “Smart” ATP‐ or microRNA‐Responsive Drug Carriers
Authors: Fischer Amit , Zhang Pu , Ouyang Yu , Sohn Yang Sung , Karmi Ola , Nechushtai Rachel , Pikarsky Eli , Willner Itamar 
Published: November 2022

AbstractThe assembly of adenosine triphosphate (ATP)‐responsive and miRNA‐responsive DNA tetrahedra‐functionalized carboxymethyl cellulose hydrogel microcapsules is presented. The microcapsules are loaded with the doxorubicin‐dextran drug or with CdSe/ZnS quantum dots as a drug model. Selective unlocking of the respective microcapsules and the release of the loads in the presence of ATP or miRNA‐141 are demonstrated. Functionalization of the hydrogel microcapsules a with corona of DNA tetrahedra nanostructures yields microcarriers that revealed superior permeation into cells. This is demonstrated by the effective permeation of the DNA tetrahedra‐functionalized microcapsules into MDA‐MB‐231 breast cancer cells, as compared to epithelial MCF‐10A nonmalignant breast cells. The superior permeation of the tetrahedra‐functionalized microcapsules into MDA‐MB‐231 breast cancer cells, as compared to analog control hydrogel microcapsules modified with a corona of nucleic acid duplexes. The effective permeation of the stimuli‐responsive, drug‐loaded, DNA tetrahedra‐modified microcapsules yields drug carriers of superior and selective cytotoxicity toward cancer cells.
Peptidyl Virus‐Like Nanovesicles as Reconfigurable “Trojan Horse” for Targeted siRNA Delivery and Synergistic Inhibition of Cancer Cells
Authors: Wang Zixuan , Hao Dongzhao , Wang Yuefei , Zhao Jinwu , Zhang Jiaxing , Rong Xi , Zhang Jiaojiao , Min Jiwei , Qi Wei , Su Rongxin , He Mingxia 
Published: November 2022

AbstractThe self‐assembly of peptidyl virus‐like nanovesicles (pVLNs) composed of highly ordered peptide bilayer membranes that encapsulate the small interfering RNA (siRNA) is reported. The targeting and enzyme‐responsive sequences on the bilayer's surface allow the pVLNs to enter cancer cells with high efficiency and control the release of genetic drugs in response to the subcellular environment. By transforming its structure in response to the highly expressed enzyme matrix metalloproteinase 7 (MMP‐7) in cancer cells, it helps the siRNA escape from the lysosomes, resulting in a final silencing efficiency of 92%. Moreover, the pVLNs can serve as reconfigurable “Trojan horse” by transforming into membranes triggered by the MMP‐7 and disrupting the cytoplasmic structure, thereby achieving synergistic anticancer effects and 96% cancer cell mortality with little damage to normal cells. The pVLNs benefit from their biocompatibility, targeting, and enzyme responsiveness, making them a promising platform for gene therapy and anticancer therapy.
Isotropic Amorphous Protective Layer with Uniform Interfacial Zincophobicity for Stable Zinc Anode
Authors: Li Wenbin , Zhang Qi , Yang Zefang , Ji Huimin , Wu Tingqing , Wang Hao , Cai Zhiwen , Xie Chunlin , Li Yixin , Wang Haiyan 
Published: November 2022

AbstractAqueous zinc‐ion batteries (AZIBs) have drawn the attention of numerous researchers owing to their high safety and cost‐effectiveness. However, the dendrite growth and side reactions of the zinc (Zn) anodes limit their further practical applications. Herein, a porous amorphous silicon nitride protective layer with high zincophobicity is constructed on the Zn anode surface, which can guide the uniform stripping/plating of Zn2+ underneath the protective layer through its isotropic Zn affinity to alleviate the growth of dendrites and by‐products. As a result, the amorphous silicon nitride‐protected Zn anode can maintain a stable Coulombic efficiency (CE) of 98.8% and low voltage hysteresis for 710 cycles in the half cell. The full cell with the as‐prepared Zn anode can deliver excellent electrochemical performances (89.0% capacity retention and 144.4 mAh g−1 discharge capacity after 1000 cycles at 4 A g−1). This work reveals the key role of uniform metal affinity induced by the amorphous materials in the interface modification of metal anodes, which is instructive for the design of stable metal anodes.
Lewis Acid–Base Adducts for Efficient and Stable Cesium‐Based Lead Iodide‐Rich Perovskite Solar Cells
Authors: Lu Hui , Li Tong , Ma Simin , Xue Xiaoyang , Wen Qian , Feng Yajuan , Zhang Xu , Zhang Lu , Wu Zhiqiang , Wang Kang , Liu Shengzhong (Frank) 
Published: November 2022

AbstractAll‐inorganic cesium‐lead‐iodide (CsPbI3Br3−x (2 < x < 3)) perovskite presents preeminent photovoltaic performance and chemical stability. Unfortunately, this kind of material suffers from phase transition to a nonperovskite phase under oxidative chemical stresses. Herein, the introduction of a low concentration of Lewis acid–base adducts (LABAs) is reported to synergistically reduce defect density, optimize interfacial energy alignment, and improve device stability of CsPbI2.75Br0.24Cl0.01 (CsPbTh3) solar cells. Both theoretical simulations and experimental measurements reveal that the noncoordinating anions, PF6−, as a Lewis base can more effectively bind with undercoordinated Pb2+ to passivate iodide vacancy defects than the BF4− and absorbed I−, and thus the point defects are well suppressed. In addition, N‐propyl‐methyl piperidinium (NPMP+) is selected to assemble with PF6− in CsPbTh3 film. The NPMP+ can regulate the crystal growth and finally homogenize the grain size and decrease the trap density. Consequently, the LABAs strategy can improve the power conversion efficiency of CsPbTh3 solar cells to 19.02% under 1‐sun illumination (100 mW cm−2). Fortunately, the NPMP+ and PF6−‐treated CsPbTh3 film shows great phase stability after storage in ambient air for 250 days, and the power conversion efficiency of corresponding solar cells is almost 76% of the initial value after 60 days aging under ambient conditions.
Effects of Polydextrose on Rheological and Fermentation Properties of Frozen Dough and Quality of Chinese Steamed Bread
Authors: Xie Xinhua , Li Jiahui , Zhu Hongshuai , Zhang Bobo , Liang Dan , Cheng Lilin , Hao Mingyuan , Guo Fangjie 
Published: November 2022

AbstractThis study investigates the effects of polydextrose on the rheological and fermentation properties of frozen dough and the quality of Chinese steamed bread (CSB). Dough is frozen by spiral tunnel freezing and stored at −18 °C for 49 days, and CSB is produced using the frozen dough. Results show that the gas producing capacity, gas holding capacity, and viscoelasticity of the frozen dough decrease as the frozen storage time progresses. However, these properties improve in the frozen dough added with polydextrose. Differential scanning calorimetric analysis shows that the melting enthalpy (ΔHm) of the frozen dough enhanced after storage. By contrast, the ΔHm of the frozen dough added with polydextrose decreases after storage, indicating high water holding capacity and homogeneous, small ice crystal structure of the frozen dough. Moreover, the addition of polydextrose reduces the hardness and porosity of CSB, which improves the quality of the bread. Thus, adding polydextrose can improve the rheological and fermentation properties of frozen dough and the quality of CSB.
Review of Studies on Energy‐Efficient Train Operation in High‐Speed Railways
Authors: Zhu Chengkun , Lu Jingtao , Li Xin 
Published: November 2022

AbstractEnergy‐efficient train operation (EETO) in high‐speed railways (HSRs) is an extra cost‐effective and flexible means to promote energy‐saving. This paper first examines the energy consumption sources and energy‐saving measures of high‐speed trains (HSTs). Then presents the EETO in HSRs, including three categories: energy‐efficient train control, energy‐efficient train timetabling, and EETO considering train timetabling and driving strategy. Next, the current research status and progress on three aspects of EETO in HSRs, namely optimization algorithm, constraint condition, and oriented scenario, are sorted out. Finally, the research on EETO in HSRs has prospected and proposed directions that can study in depth in the future. By summarizing and reviewing the research on EETO in HSRs, it is hoped to furnish a reference for the railway sector to enhance quality, efficiency, and green, low‐carbon development. © 2022 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
Introduction
Authors: Gailhofer Peter , Krebs David , Proelss Alexander , Verheyen Roda , Schmalenbach Kirsten 
Published: November 2022

AbstractTo date, international and transboundary liability has been an underutilised tool for international environmental protection. This book seeks to address this shortcoming by exploring what is needed in terms of legislative action and by identifying options for judicial discretion. This has been done to provide a legal contribution that furthers the development of an effective international and transnational environmental liability law regime. To this end, the book takes a broad view of the law of corporate liability for transboundary environmental damage.
The Nagoya-Kuala Lumpur Supplementary Protocol on Liability and Redress to the Cartagena Protocol on Biosafety
Authors: Gailhofer Peter 
Published: November 2022

AbstractThe Cartagena Protocol on Biosafety (hereafter: Cartagena Protocol) was adopted on 29 January 2000 as a supplementary agreement to the Convention on Biological Diversity and entered into force on 11 September 2003. The Cartagena Protocol pursues the goal of reconciling the economic interests of the biotechnology industry with environmental concerns and, by doing so, is supposed to provide a framework to meet the respective needs of trade and environmental protection with respect to the rapidly growing global biotechnology industry. On the one hand, the Protocol is designed to enable the access to and transfer of technologies regarding the development and use of living modified organisms (LMOs) which are seen to potentially provide considerable socio-economic benefits. Such a typically commercial use may be contained in controlled settings, or involve the release of the organisms into the environment for application in agricultural or industrial production-processes or products. This entails serious risks of environmental damage. The Cartagena Protocol, therefore, seeks to ensure the development of appropriate procedures to enhance the safety of biotechnology, to reduce potential threats to biological diversity, taking also into account the risks to human health. It does so with a particular focus on transboundary movements. The reasons cited for the need for a specific liability regime regarding LMOs and the potential damage they may cause relate to many of the specific problems associated with such organisms: For example, once LMOs are released, the transgenes cannot be easily recalled or removed from the environment. There may be possible long-term effects, whereby damage may only appear over time or even increase incrementally over time. Furthermore, some of the difficulties common to liability in an environmental damage context become acute when dealing with LMOs, such as in proving damage and causation, valuing areas damaged by LMOs, which may be not as well developed under existing liability regimes, as well as defining the affected persons who can bring a claim, e.g., on behalf of the environment or affected communities.
Protocol on Liability and Compensation for Damage Resulting from Transboundary Movements of Hazardous Wastes and Their Disposal
Authors: Gailhofer Peter 
Published: November 2022

AbstractThe Basel Convention on the Control of Transboundary Movements of Hazardous Wastes and Their Disposal (hereafter: Basel Convention) was adopted in 1989. It was a reaction to heightened international awareness of the exponential growth of hazardous waste being produced and the risks it presented to human health, property and the environment while being transported around the globe. The Basel Convention primarily aims to minimise the generation and transboundary movements of hazardous wastes and to keep risks at a tolerable level. It was also a response to the practice of exporting increasing amounts of hazardous waste from the Global North to the Global South. Hence, the Convention is supposed to address concerns regarding environmental justice which arise when industrialised countries profit by exploiting the precarious economic positions of nations in the Global South. Economically challenged countries may accordingly be under pressure to prioritise economic development over environmental concerns when they are offered foreign payments in exchange for accepting toxic waste shipments. By dealing with the disproportionately large share of the burden regarding hazardous waste developing nations face, the Basel Convention has been touted as one of the international agreements at the forefront of integrating environmental justice principles into global trade.
Paris Agreement
Authors: Schmalenbach Kirsten 
Published: November 2022

AbstractArticle 8 of the Paris Agreement, in its para. 1, recognises the importance of averting, minimising and addressing loss and damage associated with the adverse effects of climate change. With this, Article 8 connects with the Warsaw International Mechanism (WIM)-work programme of 2013 which specifies that adverse effects resulting from climate change can be both sudden and slow onset events.
International Standards for National Environmental Liability Regimes
Authors: Schmalenbach Kirsten 
Published: November 2022

AbstractCivil liability conventions are generally seen as instruments that push the costs of pollution into the polluter’s sphere, thereby implementing the ‘polluter pays principle’ (Chap.2¶10 (Sect.2.2.1)). If ratified, they have many advantages when compared to national tort laws: First, they facilitate cross-border lawsuits within their scope of application as civil liability conventions harmonise the domestic tort regimes in all the contracting States. Second, civil liability conventions introduce strict liability whereas general tort law is based on fault or negligence. In terms of disadvantages, at least from an environmental law perspective, is the fact that civil liability conventions serve to shield operators from exposure to excessive claims via liability caps, which is a deviation from the full-compensation principle of tort law.
Advancing E-health Interventions in Cancer Control and Survivorship for Hispanic/Latina Breast Cancer Patients
Authors: Baik Sharon H. , Buscemi Joanna , Oswald Laura B. , Buitrago Diana , Guitelman Judith , Iacobelli Francisco , Simon Melissa A. , Penedo Frank J. , Yanez Betina 
Published: November 2022

AbstractHispanic/Latina breast cancer survivors (BCS) in the United States experience disparities in survivorship outcomes, including worse health-related quality of life (HRQOL) and symptom burden than non-Hispanic/Latina BCS. Despite documented efficacy among BCS in general, few psychosocial interventions are specifically designed for Hispanic/Latina BCS. With increasing technology use among US Hispanics/Latinos, e-health interventions such as smartphone applications can deliver more easily accessible, scalable, and culturally tailored psychosocial interventions. Two culturally informed smartphone applications for Hispanic/Latina BCS—My Guide (intervention) and My Health (control)—were developed and evaluated. Results demonstrated the feasibility of study procedures and the high acceptability of both applications, which showed improvements in breast cancer well-being and symptom burden over time. A third application—My Guide for Breast Cancer Treatment—was developed to expand the focus of My Guide to Hispanic/Latina women currently in active treatment for breast cancer; a second pilot randomized controlled trial will compare this new application to usual enhanced care. Given the lack of culturally tailored, evidence-based, e-health psychosocial interventions for Hispanic/Latina BCS, My Guide and My Guide for Breast Cancer Treatment may bridge a gap in cancer care, providing needed psychosocial resources to this underrepresented population. E-health supportive and behavioral interventions focused on breast cancer, and its treatment may improve patient engagement as well as patient-reported outcomes among Hispanic/Latina women during active treatment for breast cancer and into survivorship.
Supportive Care Needs and Coping Strategies Used by Latino Men Cancer Survivors
Authors: Martinez Tyson Dinorah , Ruiz Erik L. 
Published: November 2022

AbstractBy the end of 2020, over 1.8 million Americans will be diagnosed with cancer and 600,000 will die from the disease. Despite experiencing lower incidence rates of cancer compared to non-Hispanic Whites, the Hispanic population in the United States faces a number of barriers to care, which may result in more involved, costlier, and potentially less successful treatments. Hispanic men in particular experience disproportionate cancer-related health disparities compared to other racial and ethnic groups and Hispanic women. Hispanic men cancer survivors (HMCS) have unique supportive care needs and use a variety of coping mechanisms, which remain largely unaccounted for and unaddressed. This chapter presents a brief description of cancer epidemiology and relevant disparities in diagnosis and care for the Hispanic population in the United States. It also explores merging research centered on preliminary data about the supportive care needs of HMCS and concludes with recommendations for public health research and practice.
Optimizing Engagement of the Latino Community in Cancer Research
Authors: Baezconde-Garbanati Lourdes , Martinez Bibiana , Ochoa Carol , Murphy Sheila , Barahona Rosa , Aristizabal Carolina , Rodriguez Yaneth L. 
Published: November 2022

AbstractTo optimize engagement of Latino communities in cancer research, University of Southern California researchers are working with communities on prevention of cervical cancer, a highly preventable and treatable disease. Two recent studies from their signature initiatives, Es Tiempo and Tamale Lesson, are presented to illustrate the situation in the Latino community regarding the human papillomavirus (HPV) vaccination and cervical cancer screening. These population-based studies included promotores de salud (lay community health workers) and community members who were engaged from conceptualization, recruitment, translation, cultural adaptation, information dissemination, and other important aspects of the research. A third exploratory effort used virtual reality as a research tool to better understand vaccine hesitancy, especially among boys and explored end-of-life quality improvements for immigrant Latino populations. These studies serve as a backdrop for discussing common strategies to increase participation in cancer research in key areas such as information delivery, consultation with stakeholders and partners, and collaboration with community opinion leaders. Strategies are discussed, which optimize engagement in cancer research, stimulate communication, and empower participants to engage in research. These strategies shape attitudes, beliefs, and behaviors, improving outcomes for Latinas at risk of cervical and other HPV-related cancers.
Contextualising Cultural Participation
Authors: Heikkilä Riie 
Published: November 2022

AbstractThis chapter contextualises cultural participation as one of the three dimensions of cultural practices. It first discusses cultural participation as a positional good and as a vehicle of social exclusion. The chapter then introduces some of the main contributions arguing that the highbrow-oriented culture could be losing its distinctive value—most importantly, the discussions on the ‘rise of the omnivore’ and the ‘meltdown scenario’. This chapter also summarises the research on the cultural practices of different underprivileged classes. It is argued that moral boundaries are an important means for underprivileged classes to defend their worth in a scenario of ‘lacking’ cultural or economic resources. Finally, this chapter shows that public cultural policy serves as an important tool for validating specific kinds of cultural participation.
What Do We Know About Cultural Participation and Non-participation?
Authors: Heikkilä Riie 
Published: November 2022

AbstractThis chapter deals with the social underpinnings of cultural participation. The most common socio-economic indicators predicting low cultural participation across different national contexts are discussed. It is argued in the light of other empirical studies that the operationalisations are often far from solid and tend to depart from highbrow-oriented participation. This means that many forms of more mundane participation often remain invisible and that activity outside of conventional culture is easily labelled as inactivity or passivity. The everyday participation debate is discussed here as a reminder of the importance of the many informal and locally negotiated cultural practices for understanding cultural participation and non-participation. Finally, it is argued that different understandings of the value of culture are at the heart of the cultural policy debates.
Conclusion
Authors: Heikkilä Riie 
Published: November 2022

AbstractThis chapter summarises the main findings. First, cultural non-participation is first and foremost a methodological artefact. Second, cultural non-participation (in highbrow-oriented activities) is only in some cases ‘compensated’ by informal social of kin-based participation. Rather, there are generally very active people and people who mostly engage in everyday pursuits. Third, the three main categories of talking about cultural non-participation in Finland were the following three: ‘affirmation’, ‘functionality’ and ‘resistance’ discourses. The chapter then discusses the problematic role of cultural policy in subverting existing hierarchies. After discussing briefly the main limitations, the chapter concludes that the best possibilities for equalising or at least balancing cultural participation lie in an equal society and that understanding this is key in our societies characterised by cultural divides.
Piezo1-expressing vocal fold epithelia modulate remodeling via effects on self-renewal and cytokeratin differentiation
Authors: Foote Alexander G. , Lungova Vlasta , Thibeault Susan L. 
Published: November 2022

AbstractMechanoreceptors are implicated as functional afferents within mucosa of the airways and the recent discovery of mechanosensitive channels Piezo1 and Piezo2 has proved essential for cells of various mechanically sensitive tissues. However, the role for Piezo1/2 in vocal fold (VF) mucosal epithelia, a cell that withstands excessive biomechanical insult, remains unknown. The purpose of this study was to test the hypothesis that Piezo1 is required for VF mucosal repair pathways of epithelial cell injury. Utilizing a sonic hedgehog (shh) Cre line for epithelial-specific ablation of Piezo1/2 mechanoreceptors, we investigated 6wk adult VF mucosa following naphthalene exposure for repair strategies at 1, 3, 7 and 14 days post-injury (dpi). PIEZO1 localized to differentiated apical epithelia and was paramount for epithelial remodeling events. Injury to wildtype epithelium was most appreciated at 3 dpi. Shhcre/+; Piezo1loxP/loxP, Piezo2 loxP/+ mutant epithelium exhibited severe cell/nuclear defects compared to injured controls. Conditional ablation of Piezo1 and/or Piezo2 to uninjured VF epithelium did not result in abnormal phenotypes across P0, P15 and 6wk postnatal stages compared to heterozygote and control tissue. Results demonstrate a role for Piezo1-expressing VF epithelia in regulating self-renewal via effects on p63 transcription and YAP subcellular translocation—altering cytokeratin differentiation.