bluuebunny/crossref_metadata_2025_split huggingface dataset:
VersorgungsNOT – Psychotherapie als zentrale, aber marginalisierte Versorgungsleistung im Gesundheitssystem
Authors: Rieß Gabriele , Löffler-Stastka Henriette 
Published: December 2022

ZusammenfassungDer Artikel geht der gesellschaftsrelevanten Frage nach, welche Versorgungskonzepte und Qualitätssicherungsmaßnahmen erforderlich sind, um der Psychotherapie als Behandlung einen versorgungsrelevanten Stellenwert in der österreichischen Gesundheitsversorgung einzuräumen. Er geht auf soziologische Ursachen für den Anstieg psychischer Krankheiten sowie auf Fakten zum Bedarf, auf Prävalenzzahlen, Versorgungsdaten und -mittel ein und beschreibt, wie die Entwicklung einer Nationalen Strategie Psychische Gesundheit helfen kann, die flächendeckende Versorgung mit Psychotherapie zu verbessern.Der Artikel beruht auf den Erkenntnissen der Autorinnen aus der Tagung 2020 „VersorgungsNOTwendigkeit – Versorgung in der NOT“ – veranstaltet von der Koordinationsstelle Psychotherapieforschung an der Gesundheit Österreich GmbH – und der vertieften Auseinandersetzung zum Thema Psychotherapieversorgung bzw. Versorgungsnot: In Fokusgruppen bzw. im Fachbeirat der Koordinationsstelle wurden die Fragen der Psychotherapieversorgung diskutiert sowie eine Literaturanalyse und vertiefende exemplarische explorative Interviews zum Thema durchgeführt. Der Artikel bietet erste Ergebnisse dieser Analysen, Recherchen, Reflexionen und die Schlussfolgerungen der Autorinnen.
Gas price caps and electricity production effects in the context of the Russo-Ukrainian War: modeling and new policy reforms
Authors: Roeger Werner , Welfens Paul J. J. 
Published: December 2022

AbstractThe merit-order approach in the electricity market, which is in widespread use across the EU27 and the UK, has proven to be somewhat economically problematic in the context of the Russo-Ukrainian War. The massively increased gas prices since summer 2022—in the context of Russian supply cuts to the EU—has led to an abnormally high electricity price. Using the merit order approach, the price of electricity increases enormously if, as is often the case, gas is the last type of energy still realized in power generation; this leads to artificial increases in returns for all other types of energy providers whose output is used in power generation. Gas price increases by Russia or Russian supply cuts to the EU can increase the price of electricity and also the rate of inflation, as well as depress real income. The electricity price shock can be countered by switching—temporarily—to a modified regulation of the electricity market for a few years with a gas price subsidy in the electricity market. In a macroeconomic analysis, we identify both the output losses and adverse distributional effects of a gas price hike and find that a gas price subsidy is superior in stabilizing output and employment compared to a transfer; it also at least partially addresses certain distributional issues by reducing windfall profits in the electricity market. The study advocates a combination of gas price subsidies only in the electricity market and targeted transfers to households to meet both efficiency and distributional targets. The macro-analysis findings presented herein should be considered carefully, as they could minimize the welfare losses in the EU and the UK. As regards the expansion of renewable energy-based electricity, it is shown herein that the cost-differential between gas-fired power stations and renewable electricity is critical—large cost differentials imply barriers for the expansion of electricity generation from renewables unless there is a price regulation of electricity. There is the potential for an inefficient adjustment path due to nonlinearities. With a proposed narrow gas price cap for the electricity market only, the associated initial deficit related to necessary subsidies is, of course, much smaller than in the case of a general gas price cap.
Competitive location problems: balanced facility location and the One-Round Manhattan Voronoi Game
Authors: Byrne Thomas , Fekete Sándor P. , Kalcsics Jörg , Kleist Linda 
Published: December 2022

AbstractWe study competitive location problems in a continuous setting, in which facilities have to be placed in a rectangular domain R of normalized dimensions of 1 and $$\rho \ge 1$$

ρ
≥
1

, and distances are measured according to the Manhattan metric. We show that the family of balanced facility configurations (in which the Voronoi cells of individual facilities are equalized with respect to a number of geometric properties) is considerably richer in this metric than for Euclidean distances. Our main result considers the One-Round Voronoi Game with Manhattan distances, in which first player White and then player Black each place n points in R; each player scores the area for which one of its facilities is closer than the facilities of the opponent. We give a tight characterization: White has a winning strategy if and only if $$\rho \ge n$$

ρ
≥
n

; for all other cases, we present a winning strategy for Black.
Ocular toxicity of investigational anti-cancer drugs in early phase clinical trials
Authors: Takamizawa Shigemasa , Katsuya Yuki , Chen Yi-Ning , Mizuno Takaaki , Koyama Takafumi , Sudo Kazuki , Yoshida Tatsuya , Kondo Shunsuke , Iwasa Satoru , Yonemori Kan , Shimizu Toshio , Yamamoto Noboru , Suzuki Shigenobu 
Published: December 2022

SummaryOcular toxicities arising from anti-cancer drugs occur sporadically and are sometimes underestimated because they are not life-threatening. Reports focusing on ocular toxicities from cancer therapy are limited. We investigated the detailed progress of ocular toxicities of anti-cancer drugs including first-in-class ones. A retrospective review of medical records was conducted for patients who were involved in early phase clinical trials with scheduled ophthalmologic examinations according to their protocols between January 2014 and August 2021. Patients with ocular toxicity suspected to be related to the investigational drugs in the ophthalmic examination were investigated in detail. In total, 37 ocular toxicities related to investigational drugs occurred in 7.6% of patients (33/434). The median age of the 33 patients was 61 years (range, 33–76 years), and 20 were male. Causal drugs with a high incidence of ocular toxicities were HSP90 inhibitors and FGFR inhibitors. Retinopathy was most frequent, while conjunctivitis, dry eye, keratitis, keratopathy, and uveitis were also observed. Dim vision as a subjective finding was a unique adverse event. Most patients developed ocular toxicities even though their dose was below the drug’s maximum tolerated dose. Except for one case, all ocular toxicities occurred bilaterally. About 60% (22/37) of ocular toxicity cases needed a temporary hold of the drug. All except for three cases fully recovered. This study reported the risks and timing of the onset of a variety of ocular toxicities of anti-cancer drugs, which were fundamentally controllable. (Trial registration number. Retrospectively registered)
Inter-American Society of Cardiology (CIFACAH-ELECTROSIAC) and Latin-American Heart Rhythm Society (LAHRS): multidisciplinary review on the appropriate use of implantable cardiodefibrillator in heart failure with reduced ejection fraction
Authors: Gómez-Mesa Juan Esteban , Márquez-Murillo Manlio , Figueiredo Marcio , Berni Ana , Jerez Ana Margarita , Núñez-Ayala Elaine , Pow-Chon Freddy , Sáenz-Morales Luis Carlos , Pava-Molano Luis Fernando , Montes María Claudia , Garillo Raúl , Galindo-Coral Stephania , Reyes-Caorsi Walter , Speranza Mario , Romero Alexander 
Published: December 2022

Abstract

Background
Our main objective was to present a multidisciplinary review on the epidemiology of sudden cardiac death (SCD) and the tools that could be used to identify malignant ventricular arrhythmias (VAs) and to perform risk stratification. In addition, indications and contraindications for the use of implantable cardioverter defibrillator (ICD) in general and in special populations including the elderly and patients with chronic kidney disease (CKD) are also given.

Methods
An expert group from the Inter American Society of Cardiology (IASC), through their HF Council (CIFACAH) and Electrocardiology Council (ElectroSIAC), together with the Latin American Heart Rhythm Society (LAHRS), reviewed and discussed the literature regarding the appropriate use of an ICD in people with heart failure (HF) with reduced ejection fraction (HFpEF). Indications and contraindications for the use of ICD are presented in this multidisciplinary review.

Results
Numerous clinical studies have demonstrated the usefulness of ICD in both primary and secondary prevention of SCD in HFpEF. There are currently precise indications and contraindications for the use of these devices.

Conclusions
In some Latin American countries, a low rate of implantation is correlated with low incomes, but this is not the case for all Latin America. Determinants of the low rates of ICD implantation in many Latin American countries are still a matter of research. VA remains one of the most common causes of cardiovascular death associated with HFrEF and different tools are available for stratifying the risk of SCD in this population.
Juvenile Neuropsychiatric Systemic Lupus Erythematosus: Identification of Novel Central Neuroinflammation Biomarkers
Authors: Labouret Mathilde , Costi Stefania , Bondet Vincent , Trebossen Vincent , Le Roux Enora , Ntorkou Alexandra , Bartoli Sophie , Auvin Stéphane , Bader-Meunier Brigitte , Baudouin Véronique , Corseri Olivier , Dingulu Glory , Ducrocq Camille , Dumaine Cécile , Elmaleh Monique , Fabien Nicole , Faye Albert , Hau Isabelle , Hentgen Véronique , Kwon Théresa , Meinzer Ulrich , Ouldali Naim , Parmentier Cyrielle , Pouletty Marie , Renaldo Florence , Savioz Isabelle , Rozenberg Flore , Frémond Marie-Louise , Lepelley Alice , Rice Gillian I. , Seabra Luis , Benoist Jean-François , Duffy Darragh , Crow Yanick J. , Ellul Pierre , Melki Isabelle 
Published: December 2022

Abstract
Introduction
Juvenile systemic lupus erythematosus (j-SLE) is a rare chronic autoimmune disease affecting multiple organs. Ranging from minor features, such as headache or mild cognitive impairment, to serious and life-threatening presentations, j-neuropsychiatric SLE (j-NPSLE) is a therapeutic challenge. Thus, the diagnosis of NPSLE remains difficult, especially in pediatrics, with no specific biomarker of the disease yet validated.

Objectives
To identify central nervous system (CNS) disease biomarkers of j-NPSLE.

Methods
A 5-year retrospective tertiary reference monocentric j-SLE study. A combination of standardized diagnostic criteria and multidisciplinary pediatric clinical expertise was combined to attribute NP involvement in the context of j-SLE. Neopterin and interferon-alpha (IFN-α) protein levels in cerebrospinal fluid (CSF) were assessed, together with routine biological and radiological investigations.

Results
Among 51 patients with j-SLE included, 39% presented with j-NPSLE. J-NPSLE was diagnosed at onset of j-SLE in 65% of patients. No specific routine biological or radiological marker of j-NPSLE was identified. However, CSF neopterin levels were significantly higher in active j-NPSLE with CNS involvement than in j-SLE alone (p = 0.0008). Neopterin and IFN-α protein levels in CSF were significantly higher at diagnosis of j-NPSLE with CNS involvement than after resolution of NP features (respectively p = 0.0015 and p = 0.0010) upon immunosuppressive treatment in all patients tested (n = 10). Both biomarkers correlated strongly with each other (Rs = 0.832, p < 0.0001, n = 23 paired samples).

Conclusion
CSF IFN-α and neopterin constitute promising biomarkers useful in the diagnosis and monitoring of activity in j-NPSLE.
Potential applications of basalt fibre composites in thermal shielding
Authors: Tamás-Bényei Péter , Sántha Péter 
Published: December 2022

AbstractThis present study demonstrates the applicability of basalt fibre-reinforced polymer (BFRP) composite materials in thermal shielding. Basalt fibres are produced from natural, sustainable sources and obtain comparable mechanical performance to commercial glass fibres. In addition to their mechanical strength, BFRPs have excellent chemical and heat resistance. Basalt fibres tend to have a higher thermal stability than their competitor glass fibres. The heat resistance of basalt fibres derives from the volcanic origin of the raw material basalt gabbro. These favourable features make BFRP composites an attractive group of materials for application in several industries. To test the fire resistance of the materials, we produced mono and hybrid composite plates from different types of basalt reinforcement structures (milled fibres, chopped fibres and woven fabric) and epoxy resin. Surface treatment with silane coupling agents significantly improved the mechanical and thermomechanical properties of BFRPs by up to 70%. Three-point bending tests were performed to determine the flexural properties of the composite specimens, and their fire behaviour was evaluated with a horizontal burning test, and a novel jet fire test assisted with infrared thermal imaging. Higher fibre content in hybrid laminates decreased the linear burning rate by 8%, and the maximum surface temperature was approximately 80 °C lower after jet fire impingement compared to woven reinforcement structure.
“Are You a TA Practitioner, Then?” – Identity Constructions in Post-Normal Science
Authors: Kastenhofer Karen , Bauer Anja 
Published: December 2022

Abstract:Technology assessment (TA) is a paradigmatic case for the manifold and, at times, ambiguous processes of identity formation of researchers in inter- and transdisciplinary settings. TA combines the natural, technical, and social sciences and follows the multiple missions of scientific analysis, public outreach, and policy advice. However, despite this diversity, it also constitutes a genuine community with its own discourses, conferences, and publications. To which extent “being a TA practitioner” also provides for a genuine scholarly identity is still unclear. Building on interviews with technology assessment practitioners at an academic TA institute, we ask what inter/trans/disciplinary identification patterns emerge in this field. Our analysis shows that TA practitioners adopt multiple identities, from “enthusiastic TA practitioner” to “strong interdisciplinarian” or “disciplinarian” – with distinct identity troubles inherent in all these options. We find that generational affiliation plays a vital role in identity formation. It relates to different primary orientations (towards research or advisory practices), inter/disciplinary backgrounds, contracting modes, and lengths of time spent at the TA institute. We conclude firstly, that disciplinary categories figure strongly in transdisciplinary identities; secondly, that the relation of chronos and identity warrants more substantial consideration: as time spent at a transdisciplinary institute as or as perceived options for “futuring one’s identity”; thirdly, that our understanding of academic generations could profit from a more sociological conception; and, fourthly, that TA’s multidisciplinary setup and threefold orientation towards science, society, and policy result in multiplying possible identities and thus making it difficult to form a stable community.
Analytical Workflows to Unlock Predictive Power in Biotherapeutic Developability
Authors: Trikeriotis Markos , Akbulatov Sergey , Esposito Umberto , Anastasiou Athanasios , Leszczyszyn Oksana I. 
Published: December 2022

Abstract
Purpose
Forming accurate data models that assist the design of developability assays is one area that requires a deep and practical understanding of the problem domain. We aim to incorporate expert knowledge into the model building process by creating new metrics from instrument data and by guiding the choice of input parameters and Machine Learning (ML) techniques.

Methods
We generated datasets from the biophysical characterisation of 5 monoclonal antibodies (mAbs). We explored combinations of techniques and parameters to uncover the ones that better describe specific molecular liabilities, such as conformational and colloidal instability. We also employed ML algorithms to predict metrics from the dataset.

Results
We found that the combination of Differential Scanning Calorimetry (DSC) and Light Scattering thermal ramps enabled us to identify domain-specific aggregation in mAbs that would be otherwise overlooked by common developability workflows. We also found that the response to different salt concentrations provided information about colloidal stability in agreement with charge distribution models. Finally, we predicted DSC transition temperatures from the dataset, and used the order of importance of different metrics to increase the explainability of the model.

Conclusions
The new analytical workflows enabled a better description of molecular behaviour and uncovered links between structural properties and molecular liabilities. In the future this new understanding will be coupled with ML algorithms to unlock their predictive power during developability assessment.
Plant-soil feedback in the ‘real world’: how does fire fit into all of this?
Authors: Kardol P. , Yang T. , Arroyo D. N. , Teste F. P. 
Published: December 2022

Abstract
Aims

Plant–soil feedback (PSF) is an important mechanism controlling plant growth, vegetation dynamics, and longer-term and larger-scale patterns of plant community diversity. We know that feedback between plants and soil biota depends on several external factors, such as nutrient and water availability, and interactions with neighbouring plants. We argue that in the ‘real world’, PSF are not working in isolation but instead proceed within a complex context of multiple interacting factors. Fire is one of those complex external factors which could greatly alter PSF by re-setting or re-directing plant-soil biota interactions.

Methods
We reviewed key literature on the effects of fire on soil biota and soil physicochemical properties with soil depth, to generate predictions on the complex effects of fire on PSF.

Results
We highlight that fire has strong potential to directly and indirectly affect the strength of PSF. To what extent this influences longer-term plant community trajectories depends on the interactions between fire characteristics and ecosystem type. Here, we conceptualized these effects of fire on soil properties and biota, and then discuss the main pathways through which fire should alter PSF.

Conclusions
We think that PSF processes should be nullified under and after fire. Average neutral PSF responses are expected to be more common in the short-term or within the timeframe required for major soil microbial players to regain their pre-fire abundances and diversity. We conclude by providing directions for future research and possible methods to study fire effects on PSF both in the field and under controlled conditions.
Defining networks in entrepreneurial ecosystems: the openness of ecosystems
Authors: Prokop Daniel , Thompson Piers 
Published: December 2022

AbstractThe paper draws on network theory to employ concepts of homophily and heterophily to investigate whether the presence of familiar, unfamiliar or a mix of actors in an entrepreneurial ecosystem is related to start-up rates. The empirical focus of this study is on 81 UK university entrepreneurial ecosystems and their outputs in terms of academic spinoff companies. The paper finds that university entrepreneurial ecosystems with access to actors of predominantly heterophilious character are associated with higher spinoff start-up rates. It is concluded that in stimulating the development of successful entrepreneurial ecosystems there is a clear need to focus on their openness to heterophilious actors, inclusive of other ecosystems. This is especially important in the context of network lock-in that may arise from dependence on homophilious ties.Plain English SummaryEntrepreneurial ecosystems characterised by openness to diverse actors generate more firms, as shown in a study focusing on 81 UK university entrepreneurial ecosystems. The paper studies network character of actors in entrepreneurial ecosystems and whether this character is associated with start-up rates. Specifically, it focuses on the familiarity of actors, inspecting whether it is related to greater venture formations. In so doing, the study examines 81 UK university entrepreneurial ecosystems. It finds that university entrepreneurial ecosystems that generate more ventures are associated with having a presence of actors of unfamiliar character, drawing attention to the openness of ecosystems’ networks. The key implication of the study is in recognising the link between the ecosystem’s openness to diverse actors and its entrepreneurial performance.
Synergistic inhibition of Pseudomonas fluorescens growth and proteases activities via sodium chlorite-based oxyhalogen
Authors: Abolmaaty Assem , Abdelkader Reham M. M. , Amin Dina H. 
Published: December 2022

AbstractPseudomonas fluorescens is considered among the main spoilage microorganisms due to its ability to produce proteases. Food deterioration caused by spoilage microorganisms has a major impact on food quality and the environment. The inactivation of Pseudomonas fluorescens growth and protease production was intensively investigated with the use of Salmide®, A Sodium Chlorite-Based Oxy­halogen Disinfectant. A unique M9 media was also developed to assure sufficient protease productions with different mutants of Pseudomonas fluorescens as a microbioreactor. Mutations were induced by classical whole-cell mutagenesis using N-methyl-N′- nitro-N-nitrosoguanidine (NTG). A dramatic decrease occurred in protease activity when different Salmide concentrations (5, 10, and 15 ppm) were added to the growth culture followed by a complete inhibition concentration (20, 25, 50, and 100 ppm) of Salmide. However, no significant inhibition occurred once it is secreted out of cells. Some mutants were resistant and remains highly stable with high protease production under stressful conditions of Sodium Chlorite-Based Oxy­halogen. The production of the protease showed a linear correlation with the increase in incubation time using a continuous culture bioreactor system and recorded maximum protease activity after 40 h. Our findings would offer alternative antimicrobial procedures for food and industrial sectors.
What makes an online review credible? A systematic review of the literature and future research directions
Authors: Pooja K. , Upadhyaya Pallavi 
Published: December 2022

AbstractOnline reviews of products and services are strategic tools for e-commerce platforms, as they aid in consumers’ pre-purchase decisions. Past research studies indicate online reviews impact brand image and consumer behaviour. With several instances of fake reviews and review manipulations, review credibility has become a concern for consumers and service providers. In recent years, due to growing webcare attitude among managers, the need for maintaining credible online reviews on the e-commerce platforms has gained attention. Though, there are several empirical studies on review credibility, the findings are diverse and contradicting. Therefore, in this paper, we systematically review the literature to provide a holistic view of antecedents of online review credibility. We examine variables, methods, and theoretical perspective of online review credibility research using 69 empirical research papers shortlisted through multi-stage selection process. We identify five broad groups of antecedents: source characteristics, review characteristics, consumer characteristics, interpersonal determinants in the social media platform and product type. Further, we identify research issues and propose directions for future research. This study contributes to existing knowledge in management research by providing the holistic understanding of the “online review credibility” construct and helps understand what factors lead to consumers’ belief in the credibility of online review. The insights gained would provide managers adequate cues to design effective online review systems.