bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multi-centric descriptive study of environmental cleaning practices in government-run tertiary care hospitals of a developing nation
Authors: Richhariya Megha , Poonam  , Kumar Parmeshwar , Sharma DK , Singh Soubam Iboyaima , Khare Amitesh 
Published: June 2022

Abstract
A. Background: The amount of microorganism present in the environment around a patient is directly proportionate to the incidence of infection in hospitals and other health care settings. The presence of such microorganisms can be reduced by simple measures like cleaning and disinfecting. The National Guidelines for Clean Hospitals were envisaged in the year 2015 by Government of India with the mandate of strengthening and streamlining the environmental cleaning practices among hospitals, across country.The aim of the study was to measure compliance of the environmental cleaning practices being observed in various hospitals vis a vis National Guidelines for Clean Hospitals.B. Methods: This was a descriptive, cross-sectional study that was carried out over a period of 18 months in four government-run tertiary care hospitals in the capital city of a developing nation. The compliance was measured by incorporating parameters from the guidelines into a tool, developed and validated by the investigators. Direct observations were made to analyse the gaps between the guidelines and cleaning practices.C. Results: The overall compliance to guidelines in each hospital was found to be between 41% to 55 % with a mean of 46.09%. The outsourced housekeeping manpower outnumbered the regular manpower. Each hospital had a well-defined organizational structure but the span of control was too wide. The most compliant cleaning practices were observed to be the cleaning of floors, OT Tables and exterior surfaces of various machinery & equipment. The frequency and methods of cleaning were fully compliant. The most non-compliant parameter was use of non-permeable apron and gum-boots while cleaning by the housekeeping personnel. The compliance to all parameters were better in High Risk areas of the Hospitals. Each hospital was using visual inspection and microbial cultures to assess the cleanliness. Material safety data sheet was not available in 3 out of 4 hospitals. is a mandatory requirement it should not be overlooked as was observed in 3 hospitals and the chemical cleaning agent refill bottles were not labelled in any of hospitals.D. Conclusion: The organizational structure of an institution plays a very important role in the performance of its employees at every level. Hence, the lack of appropriate span of control could be attributed to the overall low compliance of each hospital to the guidelines.E. Trial Registration: NA
Resveratrol Ameliorates LPS-induced Acute Lung Injury Mouse Model
via Induction of Tristetraprolin
Authors: Sun Xiuzhen , Zhang Yonghong , Wang Guizuo , Zhang Dexin 
Published: June 2022

Aim:
In this study, we aimed to investigate whether resveratrol has anti-inflammatory
effects on LPS-induced ALI via TTP enhancement.

Background:
Acute lung injury (ALI) is a syndrome of diffuse infammatory lung injury with increased
pulmonary edema and the rapid onset of hypoxemic respiratory failure. Resveratrol is a stilbenoid,
a form of natural phenol, and a phytoalexin produced by a variety of plants in reaction to injury
or when they are attacked by pathogens like bacteria or fungi. Resveratrol exhibits a potent antiinflammatory
effect in LPS-induced ALI, while the underlying mechanisms remain elusive.

Objective:
Tristetraprolin (TTP) is a RNA binding protein that is an important endogenous inhibitor
of inflammation. The objective of the present study is to investigate whether resveratrol has anti-
inflammatory effects on LPS-induced ALI via TTP enhancement.

Methods:
Forty male C57BL/6 mice were randomly assigned to four groups and intratracheally instilled
with 5 mg/kg lipopolysaccharide (LPS) to induce ALI.

Results:
LPS-induced lung pathological damage, lung edema, and neutrophil infiltration were reduced
by resveratrol pretreatment. Furthermore, resveratrol inhibited the LPS-induced rise in TNF-
α, IL-1β and IL-6 levels in BAL fluids. In the LPS-challenged mouse's lung tissue, resveratrol
clearly boosted sirtuin1 (SIRT1) and TTP protein expression, while also increasing TTP expression
while reducing proinflammatory cytokines. EX527, on the other hand, reversed resveratrol's
effects.

Conclusion:
According to our findings, resveratrol attenuated pulmonary inflammation and lung
injury in mice with LPS‑induced ALI， at least partly correlated with promoting the activation of
SIRT1/TTP signaling pathway, highlighting these pathways as potential targets for intervention in
LPS -induced lung injury.
Homeodomain Interacting Protein Kinase 2-Modified Rat Spinal
Astrocytes Affect Neurofunctional Recovery After Spinal Cord Injury
Authors: Shang Jingbo , Li Renbo , Han Jian , Chen Bo 
Published: June 2022

Background:
Spinal cord injury (SCI) is regarded as an acute neurological disorder, and
astrocytes play a role in the progression of SCI.

Objective:
Herein, we investigated the roles of homeodomain-interacting protein kinase 2 (HIPK2)-
modified rat spinal astrocytes in neurofunctional recovery after SCI.

Methods:
Rat spinal astrocytes were cultured, isolated, and then identified through microscopic
observation and immunofluorescence staining. Astrocytes were infected with the adenovirus vector
overexpressing HIPK2 for modification, and proliferation and apoptosis of astrocytes were examined
using Cell Counting Kit-8 method and flow cytometry. SCI rat models were established and
treated with astrocytes or HIPK2-modified astrocytes. Subsequently, rat motor ability was analyzed
via the Basso-Beattie-Bresnahan (BBB) scoring and inclined-plane test, and the damage to spinal
cord tissues and neuronal survival were observed via Hematoxylin-eosin staining and Nissl staining.
The levels of HIPK2, brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic
factor (GDNF), interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and nuclear factor erythroid 2-
related transcription factor 2 (Nrf2)/antioxidant response element (ARE) pathway-related proteins
were detected.

Results:
Rat spinal astrocytes were harvested successfully. HIPK2 overexpression accelerated the
proliferation and repressed the apoptosis of rat spinal astrocytes. Rat spinal astrocytes treatment
increased BBB points and the maximum angle at which SCI rats remained stable, ameliorated damage
to spinal cord tissues, increased the number of neurons, and attenuated neural damage and inflammation,
while the treatment of HIPK2-modified rat spinal astrocytes imparted more pronounced
effects to the neurofunctional recovery of SCI rats. Meanwhile, HIPK2-modified rat spinal astrocytes
further activated the Nrf2/ARE pathway.

Conclusion:
HIPK2-modified rat spinal astrocytes facilitated neurofunctional recovery and activated
the Nrf2/ARE pathway after SCI.
Prenatal Learning and Memory: Review on the Impact of Exposure
Authors: Chamallamudi Mallikarjuna Rao , Kumar Nitesh , Kamath Sushmitha , Kumar Gautam , Vaishali K. , Sinha Mukesh Kumar , Amin Revati 
Published: June 2022

Background:
Prenatal Learning is a topic still debated for its existence, although the concept is well known since ancient times.

Objective:
The present review highlights the impact of various stimuli on learning and memory in prenatal and postnatal life.

Method:
For review, various articles from preclinical and clinical studies providing early pieces of evidence of prenatal learning to date were included based on the relevancy of the databases, namely, Scopus, Pubmed, and Google Scholar.

Results:
Learning is the process of acquiring skills/ preferences/ habits from the experiences of the exposures of the past. These exposures are the stimuli, which help in categorizing learning into as-sociated or nonassociated learning. The stimuli of adults related to auditory, gustatory, olfactory, visual, touch, etc. are also accessible to the prenatal life in utero either directly or indirectly through the mother. The effects of these stimuli are remarkable during prenatal life and can be seen clearly in infants. These stimuli play an important role in prenatal learning and contribute to neuronal de-velopment. The present review summarizes the pieces of evidence for each of these types of learn-ing & their impact on the ex utero life, a futuristic view & the scope of understanding prenatal learning. The review also elucidates the factors affecting prenatal learning.

Conclusion:
Studies from clinical and preclinical studies reflected the impacts of several aspects of an infant’s life and the memory created during prenatal life was found to be most likely carried on to postnatal life.
Glucosamine Sulphate Potassium Chloride in the Management of
Osteoarthritis- Considering Emulgel Dosage Form: A Review
Authors: Rao Komal , Minocha Neha 
Published: June 2022

Background:
In addition to lifestyle, diet, environmental, and physiological factors, genetics
also contributes to an increase in mitochondrial vulnerability. With depression, the hypothalamic,
pituitary, and adrenal (HPA) axis are overactive, which is linked to higher CNS glucocorticoid
levels. In recent years, topical drug delivery has been used on a priority basis compared to other
drug delivery systems because of its specific site action and sustained release capacity. An emulsion
gel is prepared by an emulsion incorporated into a gel by a gelling agent. Glucosamine Sulphate Potassium
Chloride (GSPC) is used to treat osteoarthritis. It does this by increasing the production of
proteoglycans, which can cause the cartilage to break down.

Objectives:
The aim behind choosing the glucosamine sulphate potassium chloride for the management
of Osteoarthritis (OA) is that it has many clinical investigations and has topical properties
which are effective against osteoarthritis.

Method:
Osteoarthritis is a prevalent rheumatic musculoskeletal disorder. It is a pervasive disorder
affecting people worldwide and can affect any joint, mainly the knees, hips, spine, and hand joints.
The review is based on many studies extracted from Google Scholar, Google Patents, etc. Data from
other sources were gathered to do further research on osteoarthritis.

Result:
Extensive literature was studied about Glucosamine Sulphate Potassium Chloride. It has
been shown that GSPC is effective against osteoarthritis, and also, some patents regarding GSPC
have a therapeutic effect on making our joints healthy.

Conclusion:
Topical formulations are widely used for better patient compliance, and emulgel is a
good choice regarding viscosity and spreadability. GSPC is effective against osteoarthritis; many
clinical studies have evidence of this.
Identification and Scale of the Development of a Price Bubble in the Housing Market
Authors: Solovyova E. V. , Berdnikova V. N. 
Published: June 2022

Relevance. Housing costs rose significantly in the housing market during the pandemic. Тhere was a great interest in the price from state regulatory authorities and market participants. Domestic and foreign researchers mainly identify price bubbles. They compare the income of the population, the price of rent and the cost of housing and do not pay attention to calculating the scale of speculative price bubbles. Today in Russia, the study of this problem is relevant.The purpose of the study was to develop a methodology for identifying speculative price bubbles on the real estate market. It uses the value of the fair value during the period of stability, the simulated fair value and the market value in the conditions of a hype market.The objectives of the study were to provide a dynamic analysis of the housing market, identify periods of stability of excessive price growth in the market, simulate fair value with stable values of price-forming factors and calculate the size of the price bubble.Methodology. The research is based on correlation and regression analysis, an index method of information processing.Results. The percentage sizes of speculative price bubbles were established. The fair price base in the housing market was adopted, a scale for dividing speculative bubbles was developed.Conclusion. Calculations were made for the housing market in Sochi in 2021, a euphoric price bubble of 54 per cent was calculated. Macroeconomic factors have not changed, so the market price requires special attention from interested parties.
Features of Value Attitudes in the System of Succession of Generations in Modern Society
Authors: Kobleva Z. Kh. 
Published: June 2022

The relevance of the research topic is caused by the emergence of serious scientific interest in the study of value orientations in the system of succession of generations at the present stage. The article is devoted to topical issues of generational continuity and the specifics of the formation of intergenerational ties, in order to identify the features of the value attitudes of modern youth, manifested in ways of behavior that are not characteristic of the Russian mentality in relation to the older generation.The purpose of this article is the need to identify and study the features of the formation of value orientations in the process of intergenerational relations in modern society.Objectives: to study the values of modern society in the system of generational succession; to identify the features of the relationship between the younger and older generations; to show the transformation of the system of intergenerational ties in modern conditions that form the basis of the process of generational succession of society.Methodology. In the process of writing the article, methods of systemic, structural and functional analysis were used, methods of comparison, observation, and questioning were used in the process of studying value orientations in the system of generational succession.Results. The practical significance of the article lies in the use of provisions and conclusions in the creation of family information policy of the state, aimed at strengthening ties between generations. A sociological study conducted within the framework of the problem under study made it possible to determine the attitude of young people to the older generation, analyze the features of value preferences and attitudes among young people in the system of generational succession, which revealed the need for dialogue between generations as an opportunity to ensure harmonious interaction at the intergenerational level.Conclusions. The transformational processes affecting the institution of the family, caused by modern trends in the socio-economic and political spheres, reflected in the emergence of new value attitudes among the younger generation, which are based on the dominance of individual values, without taking into account the unique, socio-cultural experience of the older generation, had a significant impact on the state of the system of traditional succession of generations. In these conditions, it is necessary to re-establish contacts that promote the establishment of traditional ties between generations, in which they will be interested in order to continue the historical and socio-cultural continuity of generations.
Development of Methodological Approaches to Assessing Client Risks of a Commercial Bank
Authors: Voronin I. A. 
Published: June 2022

Relevance. Money laundering has strong consequences throughout the world, which distort and seriously distort economic processes, since it can completely destroy the political and financial systems of a country. Credit organizations, as intermediaries in financial transactions, are the main participants in the process of legalization of income and anti-money laundering activities. Therefore, risk management becomes a decisive element for identifying actions that may indicate suspiciousness of a transaction, and associate its participants with money laundering, and requires banks to form special methodological tools.The purpose. In this article, it is planned to consider issues related to the study of methodological approaches to assessing client risks used in world practice, when assessing banks in anti-money laundering activities and the possibility of their adaptation in the activities of Russian credit institutions.Objectives. Within the framework of the scientific article, scientific tasks were set and solved to develop a methodological approach to assessing client risks (including a new client and a client with a long service period) of involvement in legalization of income.Methodology. The proposed methodological approach is implemented using linear regression and gradient boosting methodology based on a decision tree.Results. The research carried out allows us to form two models that offer solutions for identifying new and old clients whose activities involve money laundering.Conclusions. Considering that the supervisory authorities are increasingly focusing on developing the ability of banks to prevent suspicious transactions in advance, this requires a credit institution to develop a set of various tools that allow a high level of probability to identify suspicious transactions by a client and prevent them from being carried out in the bank.
Pendaftaran Indikasi Geografis Tahu Sumedang Sebagai Aset Potensial Daerah
Authors: Agung nugraha Yudha , Haryanto Imam 
Published: June 2022

Abstract
This artikel examines the Barriers to Registration of Geographical Indications of Sumedang Tofu as a Regional Potential Asset, and the Impact on its Inclusion in Geographical Indications. The purpose of this journal is to know the barriers to registration of tofu and tofu geographic indications and their impact on their inclusion in geographic indications. The research method used in the research is Normative Juridical Research which means that it is carried out by examining library materials or secondary materials, then analyzing the issues concerning Geographical Indications and their benefits to the region from which it is originated. The result of the analysis raises 2 themes discussed here: Barriers to Registration of Geographical Indications of Sumedang Tofu, and the impact on Product Inclusion in Geographical Indications. The study of these two themes is very useful to understand the Importance of Registration of Geographical Indications and also the benefits generated by inclusion in Geographical Indication products.
Abstrak
Artikel ini mengkaji tentang Hambatan Pendaftaran Indikasi Geografis Tahu Sumedang Sebagai Aset Potensial Daerah, dan Dampak terhadap Pencantumanya Kedalam Indikasi Geografis . Tujuan Jurnal ini adalah untuk Mengetahui Hambatan Pendaftaran Indikasi Geografis Tahu Sumedang Serta Dampak terhadap pencantumannya kedalam indikasi Geografis. Metode Penelitian yang digunakan dalam penelitian yaitu Penelitian Yuridis Normatif yang berarti dilakukan dengan cara meneliti bahan pustaka atau bahan sekunder., kemudian menganalisis tentang persoalan-persoalan yang menyangkut tentang Indikasi Geografis dan manfaatnya Terhadap daerah yang menjadi asalnya. Hasil analisis memunculkan 2 tema yang dibahas di sini: Hambatan Pendaftaran Indikasi Geografis Tahu Sumedang, serta dampak terhadap Pencantuman Produk Kedalam Indikasi Geografis. Kajian tentang kedua tema tersebut sangt berguna untuk memahami Pentingnya Pendaftaran Indikasi Geografis dan juga Manfaat yang dihasilkan oleh pencantuman kedalam produk Indikasi Geografis.
La creatividad como base para la calidad de vida
Authors: Pérez Márquez Edith Alejandra 
Published: June 2022

La creatividad puede utilizarse como método para lograr el éxito escolar y promover la calidad de vida en los estudiantes universitarios. La creatividad está presente en las artes, ciencia, tecnología y la sociedad, así que es parte de la vida cotidiana solucionando problemas en sus distintos niveles, , y calidad de vida corresponde con el bienestar generalizado entendiéndose como material, físico, psicológico y social, que concierne con el estilo de vida como una propiedad individual puesto que incluye muestras de seguridad en sí mismo, salud física y productividad personal.

Este estudio se diseñó mediante un tipo de investigación descriptivo, transeccional, no experimental que tiene como objetivo correlacionar la creatividad, el éxito escolar y la calidad de vida de los educandos de nivel superior, para ello se aplicó el instrumento de investigación CEECaVi a 164 estudiantes de las Unidades Académicas de Ingeniería, Enfermería y Psicología del Campus Jalpa de la Universidad Autónoma de Zacatecas, el cual analiza la creatividad, éxito escolar y calidad de vida con 107 ítems.
Como principales resultados se encontraron relaciones entre la creatividad y el uso de la tecnología para el éxito escolar mediante el autoaprendizaje para realizar proyectos y alcanzar metas establecidas, asimismo, con la valoración que tienen los estudiantes de su propio trabajo; por otra parte, existen correlaciones negativas entre la creatividad y la procrastinación, el estrés y emociones negativas. Se concluye que el uso que los estudiantes le dan a la creatividad es autónomo y se le relaciona con el éxito en general.
Automated landmark identification on cone-beam computed tomography: Accuracy and reliability
Authors: Ghowsi Ali , Hatcher David , Suh Heeyeon , Wile David , Castro Wesley , Krueger Jan , Park Joorok , Oh Heesoo 
Published: June 2022

ABSTRACT

Objectives
To evaluate the accuracy and reliability of a fully automated landmark identification (ALI) system as a tool for automatic landmark location compared with human judges.

Materials and Methods
A total of 100 cone-beam computed tomography (CBCT) images were collected. After the calibration procedure, two human judges identified 53 landmarks in the x, y, and z coordinate planes on CBCTs using Checkpoint Software (Stratovan Corporation, Davis, Calif). The ground truth was created by averaging landmark coordinates identified by two human judges for each landmark. To evaluate the accuracy of ALI, the mean absolute error (mm) at the x, y, and z coordinates and mean error distance (mm) between the human landmark identification and the ALI were determined, and a successful detection rate was calculated.

Results
Overall, the ALI system was as successful at landmarking as the human judges. The ALI's mean absolute error for all coordinates was 1.57 mm on average. Across all three coordinate planes, 94% of the landmarks had a mean absolute error of less than 3 mm. The mean error distance for all 53 landmarks was 3.19 ± 2.6 mm. When applied to 53 landmarks on 100 CBCTs, the ALI system showed a 75% success rate in detecting landmarks within a 4-mm error distance range.

Conclusions
Overall, ALI showed clinically acceptable mean error distances except for a few landmarks. The ALI was more precise than humans when identifying landmarks on the same image at different times. This study demonstrates the promise of ALI in aiding orthodontists with landmark identifications on CBCTs.