bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of contrast-enhanced ultrasound for lymph node metastasis in papillary thyroid carcinoma: a meta-analysis
Authors: Yu Yong , Shi Lin-Lin , Zhang Hua-Wei , Wang Qian 
Published: December 2022

Background
Papillary thyroid carcinoma is the most common thyroid carcinoma worldwide. Papillary thyroid carcinoma metastasis to the cervical region increases the probability of local or regional recurrence and the requirement for further surgery. Contrast-enhanced ultrasound has been suggested as a possible adjunct diagnostic technique for evaluating papillary thyroid carcinoma metastatic lymph nodes in several studies. This meta-analysis aims to evaluate the diagnostic accuracy of contrast-enhanced ultrasound for cervical lymph nodes metastatic in papillary thyroid carcinoma patients.

Methods
A search for studies evaluating the role of contrast-enhanced ultrasound for assessing cervical lymph nodes metastatic in papillary thyroid carcinoma patients from January 2000 to May 2022 was performed in PubMed, Embase, OVID, and Web of Science databases. The Quality Assessment of Diagnostic Accuracy Studies 2 evaluated the quality of the studies. All analyses were performed using Review Manager 5.3 and Stata 17.0.

Results
A total of seven articles were finally included in this study. Perfusion type, enhancement homogeneous, hilum absent, and perfusion defect were involved in the meta-analysis as the standard of contrast-enhanced ultrasound, among which, perfusion type showed the best diagnostic performance. The pooled estimated sensitivity, specificity, positive likelihood, negative likelihood ratio, and diagnostic odds ratio of perfusion type in contrast-enhanced ultrasound for detecting lymph node metastasis were 0.95 (0.91, 0.97), 0.87 (0.69, 0.96), 7.51 (2.80, 20.14), 0.06 (0.03, 0.10), and 124.17 (42.78, 360.46), respectively. Heterogeneity was moderate.

Conclusion
The perfusion type in contrast-enhanced ultrasound has good diagnostic performance for cervical lymph nodes metastasis in papillary thyroid carcinoma patients.
Funcionalidad familiar y percepcion de la satisfaccion necesidades basicas de cuidado en adultos mayores de Cartagena-Colombia
Authors: Manrique-Anaya Yolima , Escobar Velasquez Katy 
Published: December 2022

Introducción: La familia ante el envejecimiento de sus miembros debe establecer comportamientos de cuidado, apoyo emocional, empatía, escucha, entre otros además de responder a sus necesidades de cuidado. Objetivos: Describir la funcionalidad familiar y las necesidades básicas de cuidado en los adultos mayores independientes de dos localidades de Cartagena-Colombia 2020. Materiales y métodos: Estudio descriptivo, transversal y correlacional, población 1340 adultos mayores de 60 años, muestra 102 adultos mayores residentes en dos localidades; la información se recolecto por formulario Google, se usó el instrumento Apgar familiar y las 14 necesidades de Virginia Herdenson. En el análisis estadístico se empleó medidas de tendencia central y el índice de correlación chi cuadrado. Se contemplaron los aspectos éticos de respeto a los derechos humanos, beneficencia, no maleficencia y justicia. Resultados: predominó el sexo femenino con (53.9 %), en edades de 60 a 65 años con un (56.9%), en cuanto al estado civil (49%) de los adultos mayores son casados y viven en unión libre (30.4%), nivel de escolaridad (34.3%) realizó primaria; se encontró que el 50% de los adultos mayores son hipertensos; la funcionalidad familiar fue 97.9 % funcional y mostró que el vivir juntos es relevante para percibir cuidado en sus necesidades índice de correlación (p=0.014), además las mujeres perciben más cuidado que los hombres índice de correlación (p=0,036). Conclusión: El apoyo familiar es relevante en suplir las necesidades de cuidado del adulto mayor, así como el convivir en pareja mantiene y preserva las conductas de cuidado evidenciado en mantener una funcionalidad familiar normal.
Outcome of the AVID College Preparatory Program on Adolescent Health: A Randomized Trial
Authors: Dudovitz Rebecca N. , Chung Paul J. , Dosanjh Kulwant K. , Phillips Meredith , Tucker Joan S. , Pentz Mary Ann , Biely Christopher , Tseng Chi-Hong , Galvez Arzie , Arellano Guadalupe , Wong Mitchell D. 
Published: December 2022

BACKGROUND AND OBJECTIVES
Academic tracking is a widespread practice, separating students by prior academic performance. Clustering lower performing students together may unintentionally reinforce risky peer social networks, school disengagement, and risky behaviors. If so, mixing lower performing with high performing youth (“untracking”) may be protective, leading to better adolescent health.

METHODS
Advancement via Individual Determination (AVID), a nationally-disseminated college preparatory program, supports placing middle-performing students in rigorous college-preparatory classes alongside high-performing peers. We conducted the first randomized, controlled trial of AVID in the United States, randomizing 270 students within 5 large public high schools to receive AVID (AVID group) versus usual school programming (control group). Participants completed surveys at the transition to high school (end of eighth grade/ beginning of ninth grade) and the end of ninth grade. Intent-to-treat analyses tested whether AVID resulted in healthier social networks (primary outcome), health behaviors, and psychosocial wellbeing.

RESULTS
At follow-up, AVID students had lower odds of using any substance (odds ratio [OR] 0.66, 95% confidence interval [CI] 0.48–0.89) and associating with a substance-using peer (OR 0.74, 95% CI 0.45–0.98), and higher odds of associating with a peer engaged in school (OR 1.73, 95% CI 1.11–2.70). Male AVID students had lower stress and higher self-efficacy, grit, and school engagement than control students (P &lt; .05 for all). No adverse health effects among high-performing peers were observed.

CONCLUSIONS
AVID positively impacts social networks, health behaviors, and psychosocial outcomes suggesting academic untracking may have substantial beneficial spillover effects on adolescent health.
The relationship between bullying behavior and adolescents’ resilience
Authors: Hidayati Laili Nur , Fitriawanda Asfira Niken 
Published: December 2022

Introduction: Adolescence is a vulnerable phase full of changes and challenges. The changes include biological, cognitive, and social aspects. The stages of adolescents’ developmental tasks are based on ego and integrity to establish a stable self-identity and determine roles. However, identity lapses frequently occur in adolescence, such as bullying behavior that can cause psychological and physical problems in victims and perpetrators. Adolescents experiencing bullying behavior require resilience as an adaptive coping mechanism for managing external and internal pressures within the individual. This study aims to identify the relationship between bullying behavior and adolescent resilience.Methods: This study used a quantitative correlational method with a cross-sectional approach. The variables studied were bullying behavior and resilience.Results: Demographic characteristics in this study included age, gender, and living partner. The sample of this study was 163 respondents selected with the Accidental Sampling technique. This study showed that respondents who committed bullying were 99 respondents (60.7%), and those who did not were 64 respondents (39.3%). Overall, 61 respondents had a high resilience rate (37.4%). The results showed a relationship (p-value = 0.000 and r of -0.684) with a strong interpretation.Conclusion: It can be concluded that the higher the bullying behavior is, the lower the level of resilience of adolescents will be. It is expected that adolescents can use resilience as adaptive coping to prevent bullying behavior.
Public knowledge and perceptions toward cupping therapy (hijamah)
Authors: Syahruramdhani Syahruramdhani , Fadhlurrahman Fadhlurrahman 
Published: December 2022

Introduction: Complementary and Alternative Medicine (CAM) is a well-known and widely used component of the healthcare system. Wet cupping therapy is one of the therapies that many people employ (hijamah). Wet cupping therapy (hijamah) is becoming increasingly popular and widely employed in today's society. The public's understanding and perception of cupping therapy, on the other hand, is unknown. This study describes public knowledge and perceptions of cupping therapy (hijamah) in Kalirandu.Method: In this study, using a cross-sectional approach. The sample was 62 people with purposive sampling stress, which is a sampling technique with specific considerations. This study used a questionnaire of knowledge and perceptions of the people.Results: The results of this study indicate that the level of public knowledge regarding cupping (hijamah) is low as many as 41 people (66.1%), and the level of knowledge is moderate as many as 21 people (33.9%). An overview of the medium category of community perceptions of cupping (hijamah) is 49 people (79.0%), for the good perception of 12 people (19.4%), and the last for a bad perception of 1 person (1.6 %).Conclusions: This study indicates that the knowledge and perception of the public about cupping therapy need to improve.
Hematology profile of under five years old children suffered from acute diarrhea at Idaman Banjarbaru Hospital, Indonesia
Authors: Harapan Parlindungan Ringoringo  , Jun Rahmawati Surya Mentari  , Panghiyangani Roselina , Edi Hartoyo  , Rahmiati Lao  
Published: December 2022

Introduction: Acute diarrhea is fecal discharge >3 times in 24 hours occurring <14 days. Diarrhea is still a health problem in Indonesia. This study aimed to determine the hematological profile in cases of acute diarrhea in children under five. The hematological profile can help diagnose acute diarrhea.
Methods: This research method is a descriptive retrospective with data from the medical records of patients with acute diarrhea in children under five at Idaman Banjarbaru Hospital in July - October 2018. The sampling technique was carried out using consecutive sampling.
Results: In this study, a sample of 109 children, 65 boys and 44 girls, were obtained. The results showed that 69.72% of the patients had anemia, and 62.39% had iron deficiency anemia (IDA). Leukocytosis and thrombocytosis were found in 16.51%, 23.85% of patients. Basophilia, eosinopenia, band neutropenia, segmented neutropenia, normal, lymphocytosis, monocytosis were found in 100%, 67%, 99%, 67%, 66%, 60%, respectively. IDA is found in 62.39% of children under five who suffer from acute diarrhea.
Conclusion: Typical lab results are the presence of basophilia, eosinophenia, band neutropenia, lymphocytosis, and monocytosis.

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Relationship between plasma adiponectin levels and cellulite
Authors: Sari Indriayani  , Imam Budi Putra  , Nelva Karmila Jusuf  
Published: December 2022

Background: Decreased adiponectin levels as a humoral vasodilator in subcutaneous adipose tissue in the cellulite area are thought to cause microcirculation disorders and tissue hypoxia, ultimately a local fibrotic response and collagen strands (septa) resulting in the appearance of cellulite. Adiponectin accumulates in the extracellular matrix. It is suspected that an increase in adiponectin levels can suppress the process of sclerotic fibrosis, thereby inhibiting the formation of cellulite. This study aimed to determine the relationship between plasma adiponectin levels and cellulite.
Methods: This study is an analytic observational study with a cross-sectional design involving 40 cellulite patients and 40 controls. Each patient underwent a history and dermatological examination. Then proceeded to assess plasma adiponectin levels from blood samples by ELISA test. These data were analyzed statistically using the Chi-square test.
Results: In this study, both cellulite and control patients were 20-30 years with the average plasma adiponectin level in cellulite was 8.07±3.94 µg/ml. The highest cellulite location in the femoral and gluteus areas was 62.5%. The results of this study showed that there was a statistically significant relationship between plasma adiponectin levels and cellulite (p = 0.025 < 0,05).
Conclusion: There is a significant relationship between low plasma adiponectin levels and the risk of cellulite.
Hematological profile of children under five years with typhoid fever at Idaman Banjarbaru Hospital, Indonesia
Authors: Harapan Parlindungan Ringoringo  , Jun Rahmawati Surya Mentari  , Panghiyangani Roselina , Edi Hartoyo  , Rahmiati Lao  
Published: December 2022

Introduction: Typhoid fever is a disease caused by Salmonella typhi, Salmonella paratyphi A, B, C. An estimated 200,000 people die each year from about 21.6 million people infected with typhoid fever. This study aims to determine the hematological profile in typhoid fever cases in children under five at Idaman Banjarbaru Hospital.
Methods: The research was carried out with a retrospective descriptive approach with a consecutive sampling technique. The research subjects were children under five diagnosed with typhoid fever recorded in the Idaman Banjarbaru Hospital's medical records for July 2018 to January 2019.
Results: The sample consisted of 58 patients, 32 boys, and 26 girls. Most patients were found in 12 - <36 months, namely 28 (48.28%) children. Thirty-eight (65.52%) children have a normal weight. The hematological profile showed that 46.55% of the patients had iron deficiency anemia (IDA). Hematocrit levels decreased in 51.72% of patients. Erythrocyte levels in 86.21% of patients were normal. Low MCV, low MCH, IDA were found in 46.55%, 36.21%, 46.55% of patients. Leukopenia was present in 17.24% of children. All patients had normal basophil values. Eosinopenia, band neutropenia, segmented neutropenia, lymphocytosis, monocytosis were found in 69.09%, 90.90%, 56.37%, 58.18%, 58.18% of children, respectively. Thrombocytopenia and thrombocytosis were found in the same percentage, 13.80%.
Conclusion: The haematological profile of typhoid fever patients in children under five can have different results depending on each child's body's response to S. typhi and S. paratyphi that enter the body.
Comparison of acute appendicitis severity in pandemic and non-pandemic periods of COVID-19: a comparative study
Authors: Achmad Musa  , Marjono Dwi Wibowo  , Denny Septarendra  
Published: December 2022

Background: Acute appendicitis is the most common cause of abdominal surgery. The delay of diagnosis and surgery increases the risk of perforated appendicitis, which is associated with increased morbidity and mortality. The COVID-19 pandemic has an impact on the delays in the diagnosis (time-to-diagnosis) and therapy (time-to-intervention). In this study, we aimed to analyze the profiles and characteristics of acute appendicitis patients in COVID-19 pandemic and non-pandemic periods in Indonesia.
Methods: We collected samples from all patients with acute appendicitis who visited the emergency department from November 10, 2018 – February 10, 2020 (non-COVID-19 pandemic) and March 11, 2020 – August 11, 2021 (COVID-19 pandemic). The data are secondary data taken from medical records. We collected the patient’s demographic data (e.g., age and sex), operation description, length of stay, and duration of the operation.
Results: We recruited a total of 121 patients, consisting of 56 patients during the non-pandemic period and 65 patients during the pandemic. Based on the severity, patients with grade 1 were the most common during the non-pandemic period, while patients with grade 4 were the most common during the pandemic. There was a significant difference between the severity of acute appendicitis during the non-pandemic and the pandemic (P < 0.0001). During non-pandemic periods, the majority of patients were hospitalized for 3-4 days, while during the pandemic, the majority of patients required hospitalization of up to 5-6 days.
Conclusion: There was a substantial difference in the severity of acute appendicitis patients during the COVID-19 pandemic and non-pandemic periods.
Correlation between hemolysis index and storage period to potassium levels of Packed Red Cell in Sanglah General Hospital, Bali, Indonesia
Authors: Clareza Arief Wardhana  , Anak Agung Wiradewi Lestari  , I Nyoman Wande  , Sianny Herawati  , Ni Nyoman Mahartini  
Published: December 2022

Background: The quality of a blood product is determined by collecting, processing, storing, and transporting it. When blood is stored, there will be mechanical and biochemical changes. Mechanical changes consist of morphological changes and hemolysis, while one of the biochemical changes is increased plasma potassium levels. This study aimed to determine the correlation between the hemolysis index and the storage period to potassium levels of the packed red cell (PRC).
Methods: This study was a cross-sectional study at Sanglah Hospital. The sample was taken from the tube in the PRC blood bag and then a complete blood count and potassium analysis were performed. Data were analyzed using SPSS version 25 for Windows.
Results: From 70 subjects, the median hemolysis index was 0.15% (0-1.69%), the mean storage period was 12.06±4.95 days, and the mean potassium level was 12.06±3.92 mmol/L. The Spearman test results showed a positive weak significant correlation between the hemolysis index and potassium levels (r=0.360; p=0.002). The Pearson test results also showed a positive weak significant correlation between the parameter of the storage period and potassium levels (r=0.357; p=0.002).
Conclusion: There was a positive weak significant correlation between the hemolysis index and the storage period to potassium levels of the PRC.
Mielopathy’s Like Symptom in Guillain Barre Syndrome: Case Report
Authors: Ahadiyati Ida , Ardiansyah Djohan , Fadil  
Published: December 2022

Background: Guillain-Barré syndrome (GBS) is a peripheral nervous system inflammatory disease that is the most prevalent cause of acute flaccid paralysis, with an annual global incidence of 1-2 per 100,000 person-years. GBS typically appears with acute ascending flaccid paralysis and sensory abnormalities in anesthetic glove stockings; paralysis may extend to cranial muscles. Although the disease’s clinical presentation is diverse and there are multiple discrete clinical forms, myelopathy as a sign of GBS is a relatively unusual condition.
Case presentation: GBS is diagnosed in a 29-year-old woman with myelopathy symptoms such as tetraparesis, hypoesthesia below the level of second thoracal myelum, aberrant proprioceptive in lower extremities, retention of urine and anhidrosis. We perform a lumbar puncture, and a cerebrospinal fluid (CSF) examination reveals albumin-cytological dissociation. Cervico-thoracic magnetic resonance imaging (MRI) revealed no abnormalities. Demyelinating polyradiculopathy was discovered using electromyography (EMG) and nerve conduction studies (NCS).
Discussion: The classical presentation of GBS is progressive (ascending) limb weakness with decreased or absent physiological reflexes. Pharyngeal–cervical–brachial variation and face diplegia with paraesthesia are rare variations of GBS. Our patient presented with ascending limb weakness accompanied by a disturbance in the central nervous system but had similiar serological biomarker, which may be another rare variant of GBS.
Conclusion: Diagnosis of GBS is quite challenging. GBS has a wide range of clinical symptoms. EMG-NCV and lumbar puncture are still required in myelopathic individuals with normal MRI, and unusual GBS symptoms should be explored. As a result, the choice of therapy and management becomes more appropriate.
Exercise decrease the expression of MCP-1 in perivascular adipose tissue (PVAT) in obese mice
Authors: Salim Hotimah Masdan , Aisyah Aisyah , Shimabukuro Michio 
Published: December 2022

Introduction: Exercise has been believed to prevent metabolic syndrome (Mets) from occurring. Accumulation of inflammation factors such as monocytes chemoattractant protein-1 (MCP1) in adipose tissue is a factor in the development of MetS. However, the inflammatory mediators that play a role in the accumulation of macrophages are still unclear, so this study aims to determine the expression of MCP-1 in perivascular adipose tissue (PVAT).
Methods: Eight-week-old male wild-type mice, were divided into five groups. One control group was given a standard diet and four groups were given a high-fat diet (HFD) for 2 weeks. Exercise treatment was given to the HFD group by dividing HFD with exercise once a week, HFD with exercise three times a week, and HFD with exercise five times a week. As for the exercise, speed is given 10-18m/minute for 30 minutes. and this exercise is carried out for two weeks. Gene expression of MCP-1 in PVAT tissues was analyzed using quantitative chain reaction (PCR).
Results: The HFD group experienced an increase in body weight (P <0.01) and adipose tissue mass (P <0.01) compared to the control group. Furthermore, exercise decreased body weight (P <0.05) and adipose tissue in the HFD-Exc1 group (P <0.01). Furthermore, exercise tends to decrease the inflammatory mediator in macrophages MCP-1 in PVAT compared to the HFD group.
Conclusion: These results suggested that exercise partially reduces adiposity, tended to decreases MCP-1 in HFD-induced obesity.
A study of molecular docking of l-tryptophan ligand as a compound in pineapples and bananas binding with the human serotonin transporter (SERT)
Authors: Purnawati Susy , Wrasiati Luh Putu , Jaya Lesmana Cokorda Bagus , Sandra Megantara  , Lesmana Ronny 
Published: December 2022

Introduction: Low mood condition is related to a low level of brain serotonin. An early sign of depression with low mood symptoms is generally treated with psychotropic drugs that work as selective serotonin reuptake and monoamine oxidase (MAO) inhibitors (one of which is sertraline), to increase serotonin levels in the brain. There are some concerns regarding side effects available medication like serotonin syndrome, suicidality and aggressive behavior. Thus, development of alternative herbal products made from a combination of pineapple and banana extract with less side effect and its potential affinity with serotonin regulation is important.
Aim of the study: To determine potential herbal rich (banana and pineapple) of L-tryptophan and potential active compounds interaction with the human serotonin transporter.
Method: In the present study, using in silico molecular docking techniques, the active compound of banana and pineapple and its potential interaction with human serotonin transporter were assed. Docking study explored the bioactive compounds interactions with specific target like catechin, dopamine, epigallocatechin, gallic acid, L-tryptophan, malvidin, norepinephrine, pelargonidin, peonidin, and serotonin. Molecular docking simulations were performed using AutoDock 4.2 software. The docking method was validated first by re-docking sertraline (nature ligand) in a complex with PDB ID: 6AWO against the target receptor (SERT).
Result: The molecular docking results had showed that L-tryptophan, peonidin, and catechin could bind to esential amino acid residues in the binding pocket, with binding affinity -5.69, -8.63, -8.24 kcal/mol respectively.
Conclusion: L-tryptophan, peonidin, and catechin are the most promising compounds that have good potency as anti-depressant agents through SERT inhibitory activity. This compounds in bananas and pineapples have the potential to affect serotonin transporter receptors that play a role in mood and behavior.