bluuebunny/crossref_metadata_2025_split huggingface dataset:
Taking stock and moving forward: A textual statistics approach to synthesizing four decades of job insecurity research
Authors: Bazzoli Andrea , Probst Tahira M. 
Published: July 2022

We collected the abstracts of manuscripts examining job insecurity published between 1984 and 2019 and carried out a textual analysis to investigate the defining clusters, their development over time, and whether there was evidence of siloed knowledge. Results suggested that job insecurity research seems to be fragmented into disciplinary foci (organizational psychology, public health, economics, and sociology). Further analyses on the organizational psychology corpus, revealed 25 topics with distinct temporal trajectories: some were increasing (analytical advances and differentiation between cognitive and affective job insecurity) while other were decreasing (scale development). The remaining abstracts revealed 15 topics with more stable trajectories. Based on these results, we identified five areas for future organizational research on job insecurity: the changing labor market, the need to better understand the experiences of marginalized workers and non-work outcomes of job insecurity, the added-value of qualitative research, and the need to critically evaluate our assumptions as researchers. Since the paper by Greenhalgh and Rosenblatt, research on job insecurity has burgeoned. Taking an interdisciplinary perspective, we collected the abstracts of all peer-reviewed manuscripts examining job insecurity published between 1984 and 2019 and carried out a textual analysis using the Latent Dirichlet Allocation and the Reinert method to investigate (a) the defining clusters of job insecurity research, (b) the development of such clusters over time, and (c) whether there was any evidence of siloed knowledge. Results suggested that indeed job insecurity research seems to be fragmented into four main disciplinary foci (organizational psychology, public health, economics, and sociology) with relatively little cross-fertilization. We conducted further analyses of the abstracts stemming from organizational research on job insecurity, revealing 25 topics with distinct temporal trajectories (e.g., “hot” topics including the increasing use of advanced analytic techniques and differentiation between cognitive and affective job insecurity) and “cold” topics including the development of job insecurity measures). The remaining abstracts revealed 15 topics with more stable research interests over time (e.g., a continued reliance on appraisal theories). Based on these results, we identified five areas for future organizational research on job insecurity based on: the changing labor market, the need to better understand the experiences of marginalized workers and non-work outcomes of job insecurity, the added-value of qualitative research, and finally the need to critically evaluate our assumptions as researchers.
Clarifying dynamics for organizational research and interventions: A diversity example
Authors: Olenick Jeffrey , Dishop Christopher 
Published: July 2022

Interventions backfire for many reasons, one being that the dynamics governing a system are not well-understood. To better explain organizational phenomena, and to intervene in ways that yield desired consequences, an appreciation of the core insights from dynamics may be necessary to include into a researcher's toolkit. Although substantial buzz surrounds the term dynamics in organizational science, conceptual missteps are present in the literature, ultimately limiting its application. We provide a coherent description of what dynamics encompasses by (1) advancing a definition and of dynamics and comparing it to other longitudinal concepts, (2) proposing theoretical principles to help researchers apply dynamics concepts to their own research, and (3) demonstrating how dynamics may refine our ability to explain organizational phenomena and devise practical implications. Organizational researchers and practitioners are faced with many complex issues and understanding how they unfold over time is difficult. Those difficulties often lead to unexpected results when we try to address those issues. Viewing organizations from a more dynamic lens can shed light on how phenomena evolve over time as governed by the iterative application of mathematical rules. Illumination of dynamics can assist with better targeting interventions and understanding their potential effects. A dynamics lens also emphasizes continuing needs to improve research methods, such as collecting longitudinal data and engaging in computational modeling. To illustrate these points, we discuss how diversity interventions in organizations may be better understood once dynamics are applied. For example, organizations wishing to improve the diversity of their work forces must focus both on why underrepresented groups enter the organization and why they might leave. Focus on only one or the other is unlikely to generate the desired effect. Once identifying the drivers of both entering and leaving and how those factors might reinforce each other, interventions to improve diversity might be better targeted.
Design and protocol of the Buprenorphine plus Outpatient Parenteral Antimicrobial Therapy (B-OPAT) study: a randomized clinical trial of integrated outpatient treatment of opioid use disorder and severe, injection-related infections
Authors: Fanucchi Laura C. , Murphy Sean M. , Surratt Hilary , Kapadia Shashi N. , Walsh Sharon L. , Grubbs James A. , Thornton Alice C. , Nuzzo Paul , Lofwall Michelle R. 
Published: July 2022

Introduction: A marked increase in hospitalizations for severe, injection-related infections (SIRI) has been associated with the opioid epidemic. Outpatient parenteral antibiotic therapy (OPAT) is typically not offered to persons with opioid use disorder (OUD) and SIRI, though increasing evidence suggests it may be feasible and safe. This study evaluates the efficacy and cost-effectiveness of an integrated care model combining Buprenorphine treatment of OUD with OPAT for SIRI (B-OPAT) compared with treatment as usual on key OUD, infectious disease, and health economic outcomes. B-OPAT expands and incorporates key elements of established clinical models, including inpatient initiation of buprenorphine for OUD, inpatient infectious disease consultation for SIRI, office-based treatment of OUD, and OPAT, and includes more frequent clinical outpatient visits than standard OPAT. A qualitative evaluation is included to contextualize effectiveness outcomes and identify barriers and facilitators to intervention adoption and implementation. Methods: B-OPAT is a single-site, randomized, parallel-group, superiority trial recruiting 90 adult inpatients hospitalized with OUD and SIRI who require at least 2 weeks of intravenous (IV) antibiotic therapy. After screening, eligible participants are randomized 1:1 to either discharge once medically stable to an integrated outpatient treatment care model combining Buprenorphine and OPAT (B-OPAT) or to Treatment As Usual (TAU). The primary outcome measure is the proportion of urine samples negative for illicit opioids in the 12 weeks after discharge from the hospital. Key secondary OUD outcomes include self-reported number of days of illicit opioid abstinence and 12-week retention in buprenorphine treatment. The infection outcomes are completion of recommended IV antibiotic therapy, peripherally inserted central catheter (PICC) complications, and readmission related to primary SIRI. Conclusions: The B-OPAT study will help address the important question of whether it is clinically effective and cost-effective to discharge persons with OUD and SIRI to an integrated outpatient care model combining OUD treatment with OPAT relative to TAU (Clinicaltrials.gov Identifier: NCT04677114).
The Misuse of Drugs Regulations 2001: A case study in poor legislative drafting
Authors: Gallagher Cathal T 
Published: July 2022

The Misuse of Drugs Regulations 2001 (MDRs) create exemptions to the offences of possession, production, supply, and administration of controlled drugs (CDs), which are necessary to allow healthcare professionals to treat patients without rendering themselves liable to prosecution for various offences under the Misuse of Drugs Act 1971. As the scope of healthcare in the UK grows to include extended roles for an increasing number of professions, so must the law be amended to allow for these. The MDRs were poorly drafted in their original form, and this has been compounded by twenty years of equally poor amendments, leading to a degree of inaccuracy and ambiguity that is no longer acceptable. These regulations both lack internal consistency, and fail to align with the Human Medicines Regulations, such that neither healthcare professionals, their regulators, nor their representative bodies agree on either the spirit or letter of the law. There are fewer than 30 active regulations in the MDRs, of which more than half contain ambiguities originating from poor drafting. While these could be clarified by a further series of amendments, the time is right to learn from previous mistakes and start over afresh.
Remote visits for people with multiple sclerosis during the COVID-19 pandemic in Austria: The TELE MS randomized controlled trial
Authors: Altmann Patrick , Leutmezer Fritz , Ponleitner Markus , Ivkic Dominik , Krajnc Nik , Rommer Paulus Stefan , Berger Thomas , Bsteh Gabriel 
Published: July 2022

Introduction Continuous monitoring is the hallmark of managing chronic disease. Multiple sclerosis (MS), in particular, requires patients to visit their treating neurologists typically twice a year, at least. In that respect, the COVID-19 pandemic made us rethink our communication strategies. This study determined satisfaction with remote visits for people with MS (pwMS) by comparing non-inferiority to conventional visits. Methods TELE MS was a randomized controlled trial that was open to any person with MS. We randomized a volunteer sample of 45 patients. We compared satisfaction with remote visits (via phone or via videochat) with conventional outpatient visits. The primary endpoint was patient satisfaction determined by the Telemedicine Perception Questionnaire (TMPQ, min: 17 and max: 85 points) with the hypothesis of non-inferiority of televisits to conventional visits. Physician satisfaction measured on the PPSM score (Patient and Physician Satisfaction with Monitoring, min: 5 and max: 25 points) was the secondary endpoint. Results The trial met both endpoints. Mean (SD) TMPQ scores in the individual groups were 58 (6.7) points for conventional visits, 65 (7.5) points for phone visits, and 62 (5.5) points for video visits. Physician satisfaction over the whole cohort was similarly high. Median (range) PPSM scores were 23 (16–25) for the whole cohort, 19 (16–25) for conventional visits, 25 (17–25) for phone visits, and 25 (16–25) for video visits. Conclusions Televisits in multiple sclerosis yield a high level of satisfaction for both patients and treating physicians. This concept for remote patient monitoring adopted during the current pandemic may be communicable to other chronic diseases as well. ClinicalTrials.gov identifier: NCT04838990
Comparison of the Marginal and Internal Discrepancy of Metal-Ceramic Restorations Produced by Milling for Soft Metal, Direct Metal Laser Sintering and Casting Methods: An In Vitro Study
Authors: Aydın Nazlı , Ekren Orhun , Kocak Elif Figen , Ucar Yurdanur 
Published: July 2022

Aim: To evaluate the effect of ceramic firing cycles on the internal and marginal discrepancy of restorations fabricated using conventional lost wax casting (LW), direct metal laser sintering (DMLS), and milling for soft metal (MS). Materials and Methods: A total of 45 restorations were produced by LW, DMLS, and MS methods ( n = 15), according to the digital impression on the metal die representing the prepared first molar. The internal discrepancy (ID) was measured through the silicon weight method and the marginal discrepancy (MD) was measured using a light microscope. ID and MD measurements were repeated following the metal manufacturing, ceramic application, and glazing. Statistical analyses were conducted by means of two-way analysis of variance and Tukey-HSD ( α = 0.05) tests. Results: Statistically significant differences were found between the fabrication methods ( P ≤ 0.001) both for MD and ID. The mean MD values of the restorations were 31.4 ± 13.8 µm for MS, 20.8 ± 14.4 µm for LW, and 7.3 ± 6 µm for DMLS. A statistically significant increase was observed in the mean MD values of metal frameworks ( P ≤ 0.001) following ceramic and glaze applications. However, no statistically significant difference was found between the ceramic and the glaze applied stages ( P = .072). The mean ID values were 37 ± 5.7 mg for LW, 28 ± 6.1 mg for DMLS, and 21.6 ± 7.3 mg for MS. Unlike the manufacturing method, ceramic firing cycles had no effects on the ID ( P > 0.05). Conclusion: MS had the highest mean MD, but it had the lowest ID. The ceramic firing had a significantly negative effect only on MD.
Immigration status and utilization of secondary preventive treatment after ischemic stroke
Authors: Mkoma George F , Johnsen Søren P , Iversen Helle K , Andersen Grethe , Norredam Marie 
Published: July 2022

Introduction: The objective of the study was to assess use and persistence of secondary preventive treatment after ischemic stroke comparing immigrants and Danish-born residents. Patients and methods: A cohort of patients discharged with ischemic stroke (IS) diagnosis ( n = 106,224) by immigration status was identified from the Danish Stroke Registry between 2005 and 2018. We investigated use (claiming at least one prescription in 180 days post-discharge according to information from the Register of Medicinal Products Statistics) and persistence of treatment within 180 days thereafter using multivariable logistic regression and Fine and Gray models. Results: Overall, 82,078 Danish-born residents (80.6%) and 3589 (80.7%) immigrants with IS used at least one of the recommended preventive medications post-discharge. Immigrants had lower odds of use of anticoagulants and angiotensin-converting enzyme (ACE) inhibitors/angiotensin II receptor blockers (ARB) (odds ratio (OR), 0.66; 95% confidence interval (CI), 0.53–0.82 and OR, 0.87; 95% CI, 0.75–0.98, respectively) but had higher odds of use of beta-blockers (OR, 1.25; 95% CI, 1.02–1.53) than Danish-born residents after adjustment for age at stroke, sex, sociodemographic factors, duration of residence, stroke severity, and comorbidities. The odds were most evident among immigrants originating from non-Western countries. Persistence of medication use did not differ between immigrants and Danish-born residents after adjustment for sociodemographic factors and comorbidities. Conclusion: Modest disparities in use of standard guideline recommended secondary preventive medications were observed when comparing immigrants and Danish-born residents with ischemic stroke. Furthermore, no differences in persistence of medication therapy were observed.
Sacrifice to the wind gods in late Shang China – religious, paleographic, linguistic and philological analyses: An integrated  approach
Authors: Li Fa , Takashima Ken-ichi 
Published: July 2022

There is a bewildering array of rituals and sacrifices performed by the aristocratic, ruling elite in late Shāng China  (c. 13th–11th centuries BC). They range from major, regularly scheduled, ritual observances to unscheduled rituals and sacrifices directed to the ancestors and the nature gods such as the wind, rivers, mountains and other deities. They were often accompanied with apotropaic prayers. What might have been their rationale is a question that remains to be answered. Sacrificing to the wind gods, for example, is often encountered in oracle-bone inscriptions. Scholars do not seem to have examined the deeper, ontological problem of the raison d’être of various rituals and sacrifices. A closer reading of the inscriptions containing fēng 風 ‘wind’, fèng 鳳 ‘phoenix’ and other collocated words may restore their original meanings. This paper distinguishes the ‘wind’ as a natural phenomenon from the ‘wind god’, even though they are written by the same graph. It also distinguishes between dì fēng 禘風 ‘dì-sacrifice to the wind (god)’ and níng fēng 寧風 ‘appease (unwanted) winds’. Identifying collocations of the words involved is an effective way for the distinctions we will be making. The paper also explores the need for the wind sacrifices accompanied by various other sacrifices. By addressing these issues, the paper is intended to stimulate further, in-depth discussion of the ritual and sacrificial system of late Shāng China. It covers a wide-ranging topic on late Shāng religious beliefs. They are analyzed in terms of paleography, linguistics and philology in an integrated manner.
Inflammation accelerates BCR-ABL1+ B-ALL development through upregulation of AID
Authors: Zhang Ping , Qin Mengting , Wang Yang , Chen Xiaodong , Miao Yinsha , Yuan Meng , Zhou Wen , Li Dandan , Wang Dan , Wang Mengying , Ai Li , Ma Yunfeng , Dong Yanying , Ji Yanhong 
Published: July 2022

Abstract
Inflammation contributes to the initiation and disease progression of several lymphoid malignancies. BCR-ABL1-positive B-cell acute lymphoblastic leukemia (BCR-ABL1+ B-ALL) is triggered by the malignant cloning of immature B cells promoted by the BCR-ABL1 fusion gene. However, it is unclear whether the mechanism driving the disease progression of BCR-ABL1+ B-ALL involves inflammatory stimulation. Here, we evaluate BCR-ABL1+ B-ALL cells’ response to inflammatory stimuli lipopolysaccharide (LPS) in vitro and in vivo. The results indicate that LPS promotes cell growth and genomic instability in cultured BCR-ABL1+ B-ALL cells and accelerates the BCR-ABL1+ B-ALL development in a mouse model. We show that the LPS-induced upregulation of activation-induced deaminase (AID) is required for the cell growth and disease progression of BCR-ABL1+ B-ALL. Moreover, AID modulates the expression of various genes that are dominated by suppressing apoptosis genes and upregulating DNA damage-repair genes. These genes lead to facilitation for BCR-ABL1+ B-ALL progression. The heat shock protein 90 (Hsp90) inhibitors significantly reduce AID protein level and delay the disease progression of BCR-ABL1+ B-ALL upon inflammatory stimulation. The present data demonstrate the causative role of AID in the development and progression of BCR-ABL1+ B-ALL during inflammation, thus highlighting potential therapeutic targets.
Incidence and predictors of priapism events in sickle cell anemia: a diary-based analysis
Authors: Idris Ibrahim M. , Abba Akib , Galadanci Jamil A. , Aji Sani A. , Jibrilla Atiku U. , Rodeghier Mark , Kassim Adetola , Burnett Arthur L. , DeBaun Michael R. 
Published: July 2022

Abstract
We conducted one of the first prospective studies to test the hypothesis that the clinical history of priapism underestimates priapism incidence compared with a priapism pain diary. Eligibility criteria were men with sickle cell anemia (SCA) between 18 and 40 years of age who have had at least 3 episodes of priapism in the past 12 months. Seventy-one men with SCA completed the diary for at least 3 months. The first 3 months of the priapism diary were included in the analysis. A total of 298 priapism episodes were recorded, and 80% (57 of 71) of the participants had at least 1 priapism event. Priapism severity was reported in the range of moderate to the worst imaginable pain in 81.5% (263 of 298), and a total 57 participants (80%) had a median pain rating of 6 (interquartile range: 5-8) on a scale from 1 to 10. The monthly incidence rate of priapism per participant based on history versus self-report pain diary was 2.0 (95% confidence interval, 1.9-2.1) and 1.4 (95% confidence interval, 1.2-1.6), respectively (P &lt; .001). For participants that had a prior priapism episode, 80% had another episode during the 3-month interval follow-up. The median time to that second episode was 27.5 days. Major priapism occurred in 9.9% of episodes and was associated with the sum of all prospective priapism events. Men with SCA and at least 3 priapism episodes in the past 12 months are at significant risk for recurrent priapism in the following 3 months.
Circulating proteins as predictive and prognostic biomarkers in breast cancer
Authors: Veyssière Hugo , Bidet Yannick , Penault-Llorca Frederique , Radosevic-Robin Nina , Durando Xavier 
Published: July 2022

AbstractBreast cancer (BC) is the most common cancer and among the leading causes of cancer death in women. It is a heterogeneous group of tumours with numerous morphological and molecular subtypes, making predictions of disease evolution and patient outcomes difficult. Therefore, biomarkers are needed to help clinicians choose the best treatment for each patient. For the last years, studies have increasingly focused on biomarkers obtainable by liquid biopsy. Circulating proteins (from serum or plasma) can be used for inexpensive and minimally invasive determination of disease risk, early diagnosis, treatment adjusting, prognostication and disease progression monitoring. We provide here a review of the main published studies on serum proteins in breast cancer and elaborate on the potential of circulating proteins to be predictive and/or prognostic biomarkers in breast cancer.
Golgi-Localized OsFPN1 is Involved in Co and Ni Transport and Their Detoxification in Rice
Authors: Kan Manman , Fujiwara Toru , Kamiya Takehiro 
Published: July 2022

AbstractCobalt (Co) and nickel (Ni) are beneficial and essential elements for plants, respectively, with the latter required for urease activity, which hydrolyzes urea into ammonium in plants. However, excess Co and Ni are toxic to plants and their transport mechanisms in rice are unclear. Here, we analyzed an ethyl methanesulfonate (EMS)-mutagenized rice mutant, 1187_n, with increased Co and Ni contents in its brown rice and shoots. 1187_n has a mutation in OsFPN1, which was correlated with a high Co and Ni phenotype in F2 crosses between the parental line and mutant. In addition, CRISPR/Cas9 mutants exhibited a phenotype similar to that of 1187_n, demonstrating that OsFPN1 is the causal gene of the mutant. In addition to the high Co and Ni in brown rice and shoots, the mutant also exhibited high Co and Ni concentrations in the xylem sap, but low concentrations in the roots, suggesting that OsFPN1 is involved in the root-to-shoot translocation of Co and Ni. The growth of 1187_n and CRISPR/Cas9 lines were suppressed under high Co and Ni condition, indicating OsFPN1 is required for the normal growth under high Co and Ni. An OsFPN1-green fluorescent protein (GFP) fusion protein was localized to the Golgi apparatus. Yeast carrying GFP-OsFPN1 increased sensitivity to high Co contents and decreased Co and Ni accumulation. These results suggest that OsFPN1 can transport Co and Ni and is vital detoxification in rice.