bluuebunny/crossref_metadata_2025_split huggingface dataset:
Timing matters: female receptivity and mate choice in the zebrafish (Danio rerio)
Authors: Santacà Maria , Devigili Alessandro , Gasparini Clelia 
Published: October 2022

Abstract
Female choice has been documented in many animal taxa, and how we test it has been refined through years of studies on the topic. However, when designing mate choice experiments some variables, surprisingly, often remain overlooked, including receptivity and reproductive stage. Here, we aimed to assess whether the female reproductive stage influences strength and direction of mate choice in the zebrafish, Danio rerio. Females were offered a choice between two males differing in body size. We found that female choice in our experimental setup was significantly repeatable and that females preferred larger males. Nonetheless, the level of choosiness of females was affected by the time since the last spawning. Females spent more time choosing when tested 7 and 10 days after spawning rather than 4 days, indicating a higher receptivity to males from one week after the last spawning. Moreover, females preferred larger males only when tested 7 and 10 days after spawning. Our results suggest that female mate choice should take female receptivity into account, by standardizing time since the last spawning across females. More broadly, this suggests that 7–10 days since the previous spawning is the ideal time interval for zebrafish female receptivity to peak, with implications for facilities and researchers to increase egg production in natural spawning events and manual egg collection.

Significance statement
The role of pre-copulatory female mate preference has long been recognized in sexual selection. Nonetheless, female receptivity often remains overlooked in mate choice experiments especially in external fertilizing species. In the present study, we investigated if the female reproductive stage affects the strength and direction of female mate choice in an external fertilizing fish, the zebrafish, Danio rerio. We found that, when tested 7 and 10 days after spawning rather than 4 days, females spent more time choosing, demonstrating an increased receptivity to males from 1 week following the last spawning. Furthermore, only at 7 and 10 days after spawning females exibith a clear preference for the bigger males. Our study highlights the importance of considering the female receptivity in future studies assessing mate choices in this and other externally fertilizing species, and also for zebrafish facilities to increase egg production in natural spawning events and manual egg collection.
Can quantitative peritumoral CT radiomics features predict the prognosis of patients with non-small cell lung cancer? A systematic review
Authors: Wu Linyu , Lou Xinjing , Kong Ning , Xu Maosheng , Gao Chen 
Published: October 2022

Abstract
Objectives
To provide an overarching evaluation of the value of peritumoral CT radiomics features for predicting the prognosis of non-small cell lung cancer and to assess the quality of the available studies.

Methods
The PubMed, Embase, Web of Science, and Cochrane Library databases were searched for studies predicting the prognosis in patients with non-small cell lung cancer (NSCLC) using CT-based peritumoral radiomics features. Information about the patient, CT-scanner, and radiomics analyses were all extracted for the included studies. Study quality was assessed using the Radiomics Quality Score (RQS) and the Prediction Model Risk of Bias Assessment Tool (PROBAST).

Results
Thirteen studies were included with 2942 patients from 2017 to 2022. Only one study was prospective, and the others were all retrospectively designed. Manual segmentation and multicenter studies were performed by 69% and 46% of the included studies, respectively. 3D-Slicer and MATLAB software were most commonly used for the segmentation of lesions and extraction of features. The peritumoral region was most frequently defined as dilated from the tumor boundary of 15 mm, 20 mm, or 30 mm. The median RQS of the studies was 13 (range 4–19), while all of included studies were assessed as having a high risk of bias (ROB) overall.

Conclusions
Peritumoral radiomics features based on CT images showed promise in predicting the prognosis of NSCLC, although well-designed studies and further biological validation are still needed.

Key Points
• Peritumoral radiomics features based on CT images are promising and encouraging for predicting the prognosis of non-small cell lung cancer.
• The peritumoral region was often dilated from the tumor boundary of 15 mm or 20 mm because these were considered safe margins.
• The median Radiomics Quality Score of the included studies was 13 (range 4–19), and all of studies were considered to have a high risk of bias overall.
Aggressive intentions after social exclusion and their association with loneliness
Authors: Brinker V. , Dewald-Kaufmann J. , Padberg F. , Reinhard M. A. 
Published: October 2022

AbstractBoth social exclusion and loneliness are aversive experiences that can lead to hostile behavioral reactions, including aggressive behavior. This study aimed to assess whether a social exclusion scenario in the subject’s imagination elicits aggressive reactions towards an excluding person as measured with the hot sauce paradigm. Furthermore, we studied the effect of loneliness on such reactions. In total, 251 subjects (67.7% female; mean age 27.3 ± 9.3 years) participated in this study which was based on an online survey. After trait loneliness was assessed with the UCLA Loneliness scale at baseline, two imaginary scenarios were presented in randomized order, i.e., an exclusion condition (with one of two working colleagues excluding the participant from a social activity) and an inclusion condition (without exclusion). Following each scenario, participants had the task to allocate the amount of hot sauce to each colleague that they find appropriate. Participants distributed significantly more hot sauce to the excluder than to the includers. The amount of hot sauce was significantly correlated with loneliness for all includer interactions (i.e., after the inclusion as well as the exclusion scenario), but not for the interaction with the excluder. Our results support the hypothesis that social exclusion elicits aggressive behavior. Interestingly, the experience of loneliness seems to be associated with an increase in aggressive behavioral tendencies or a lack of their inhibition. The cognitive and/or emotional processes underlying the interplay between social exclusion, loneliness and aggression should be a focus of future research.
Prevalence and molecular characterization of Toxoplasma gondii in different types of poultry in Greece, associated risk factors and co-existence with Eimeria spp.
Authors: Andreopoulou Marianna , Schares Gereon , Koethe Martin , Chaligiannis Ilias , Maksimov Pavlo , Joeres Maike , Cardron Garance , Goroll Tina , Sotiraki Smaro , Daugschies Arwid , Bangoura Berit 
Published: October 2022

AbstractToxoplasma gondiiis a protozoan parasite of public health importance, infecting all warm-blooded animals, including chickens. Undercooked chicken meat or relevant products such as sausages could lead to human infections. In free-range, organic and slow-growth farming systems where the susceptibility period for chickens is extended, more knowledge about potential risk factors is essential. This study is the first seroepidemiological survey in different regions and types of chicken farms in Greece, using a major tachyzoite surface antigen-based ELISA (TgSAG1), combined with magnetic-capture PCR (mc-PCR) and bioassay for the isolation of strains from the chickens’ tissues. Potential risk factors forT. gondiiinfection in these hosts were also investigated. Additionally, the co-existence ofT. gondiiandEimeriaspp. infections was assessed to elucidate epidemiological links between these two protozoan infections. OverallT. gondiiseroprevalence was 9.5%. Of the backyard chickens sampled, 41.2% were seropositive and 70% of the organic and free-range layer farms had at least oneT. gondiiseropositive hen. No serologically positive broilers were found, although mc-PCR revealed a positive sample, highlighting the importance of accurate early-infection direct detection ofT. gondiiinfections to ensure public health.T. gondiiisolates obtained by mouse bioassay were genotyped. All belonged to type II (ToxoDB#3) as confirmed also by microsatellite typing. Production system, type of nutrition, and feeding system automation were identified as the most significant risk factors, while no association was found between the presence of cats andT. gondiiseropositivity as calculated on both a farm level and per individual bird sampled.
A Prospective, Longitudinal and Exploratory Study of Head and Neck Lymphoedema and Dysphagia Following Chemoradiotherapy for Head and Neck Cancer
Authors: Jeans Claire , Brown Bena , Ward Elizabeth C. , Vertigan Anne E. , Pigott Amanda E. , Nixon Jodie L. , Wratten Chris , Boggess May 
Published: October 2022

AbstractThe aim of the study was to examine the following: (a) the trajectory of external and internal head and neck lymphoedema (HNL) in patients with head and neck cancer (HNC) up to 12 months post-chemoradiotherapy (CRT) and (b) the relationship between HNL and swallowing function. Using a prospective longitudinal cohort study, external/internal HNL and swallowing were examined in 33 participants at 3, 6 and 12 months post-CRT. External HNL was assessed using the Assessment of Lymphoedema of the Head and Neck and the MD Anderson Cancer Centre Lymphoedema Rating Scale. Internal HNL was rated using Patterson’s Radiotherapy Oedema Rating Scale. Swallowing was assessed via clinical, instrumental and patient-reported measures. Associations between HNL and swallowing were examined using multivariable regression models. External HNL was prevalent at 3 months (71%), improved by 6 months (58%) and largely resolved by 12 months (10%). In contrast, moderate/severe internal HNL was prevalent at 3 months (96%), 6 months (84%) and at 12 months (65%). More severe penetration/aspiration and increased diet modification were associated with higher severities of external HNL (p=0.006 and p=0.031, respectively) and internal HNL (p<0.001 and p=0.007, respectively), and more diffuse internal HNL (p=0.043 and p=0.001, respectively). Worse patient-reported swallowing outcomes were associated with a higher severity of external HNL (p=0.001) and more diffuse internal HNL (p=0.002). External HNL largely resolves by 12 months post-CRT, but internal HNL persists. Patients with a higher severity of external and/or internal HNL and those with more diffuse internal HNL can be expected to have more severe dysphagia.
Temperature and precipitation in the US states: long memory, persistence, and time trend
Authors: Gil-Alana Luis A. , Gupta Rangan , Sauci Laura , Carmona-González Nieves 
Published: October 2022

AbstractThis paper investigates the time series properties of the temperature and precipitation anomalies in the contiguous USA by using fractional differentiation. This methodology allows to capture time trend components along with properties such as long-range dependence and the degree of persistence. For aggregated data, we find out that long memory is present in both precipitation and temperature since the integration order is significantly positive in the two cases. The time trend is also positive, being higher for the temperature. In addition, observing disaggregated data by states, for the temperature, there are only seven states where the time trend is not significant, with most of them located in Southeast areas, while for the rest of cases, the time trend is significantly positive. All cases exhibit long-range dependence, though the differencing parameter substantially changes from one state to another, ranging from 0.09 in Nebraska and Kansas to 0.18 in Florida and Michigan. For precipitation, the time trend is insignificant in a large number of cases, and the integration order is smaller than for the temperature. In fact, short memory cannot be rejected in fourteen states, and the highest orders of differencing are obtained in Arizona (d = 0.11) and Texas (0.12). In general, we highlight that one cannot draw conclusions about persistence and trends in these two climate-related variables based on aggregate information of the overall USA, given widespread heterogeneity across the states. Tentatively, the degree of dependence across the states seems to be negatively correlated with their level of climate-related risks and the associated preparedness in terms of handling climate change, but this conclusion requires more elaborate research in the future.
Why Children Need to Read About Plants at a Time of Climate Change
Authors: Jones Verity , MacLeod Catherine 
Published: October 2022

AbstractWe begin developing our relationship with and for Nature during childhood, and over the last 20 years research has advanced our understanding of human relationships with Nature. However, a focus on human-animal relationships dominates environmental understanding, including through the medium of literature, especially children’s literature. It is critical that children know, engage with and care for plants at this time of climate crisis and this could be facilitated through climate literature. The popularity of children’s climate fiction has increased dramatically in the last few years due to what publishers are calling the ‘Greta Thunberg effect’ – resulting in many more books now available that aim to empower young people to save the planet. However, in these texts, we argue that there is still an emphasis on animal and human consequences of climate change rather than on those of plants and the agency of plants (or lack thereof). We argue it is imperative that children understand not just the importance of human-animal relationships in regard to the climate crisis, but also the fundamental role of botanical life forms in preserving life on Earth. Taking three recently published children’s books of fiction we consider how botanical encounters are represented in these texts, and how this can undermine the perceived environmental importance of plants and people’s relationships with them. Informed by the recent work of Lykke Guanio-Uluru (2020), we consider the position plants play in these examples of contemporary children’s climate literature and encourage a more critical consideration of the place of plants.
RAPOC: The Rosseland and Planck opacity converter
Authors: Mugnai Lorenzo V. , Modirrousta-Galian Darius 
Published: October 2022

Abstract (Rosseland and Planck Opacity Converter) is a Python 3 code that calculates Rosseland and Planck mean opacities (RPMs) from wavelength-dependent opacities for a given temperature, pressure, and wavelength range. In addition to being user-friendly and rapid, can interpolate between discrete data points, making it flexible and widely applicable to the astrophysical and Earth-sciences fields, as well as in engineering. uses ExoMol, DACE, or any user defined input data, provided that it is in a readable format. In this paper, we present the code and compare its calculated Rosseland and Planck mean opacities with other values in the literature. is open-source and available on Pypi and GitHub.
Bivalve molluscs as biosensors of water quality: state of the art and future directions
Authors: Vereycken James E. , Aldridge David C. 
Published: October 2022

AbstractBiological early warning systems (BEWSs) monitor the behaviour or physiology of living organisms as an indirect mechanism to sense local environmental changes, and have become a widely established tool for monitoring water pollution. Complementary to conventional chemical and physical techniques, their strength lies in the ability to continuously monitor water quality, providing direct and rapid warning of toxic discharges. Bivalve molluscs (mussels and clams) are ideal sensing organisms for BEWSs, owing to their: high water filtration capacity; sensitivity to numerous, diverse pollutants; considerable longevity; high abundance; and wide range of physical responses to environmental change. Two behavioural metrics of bivalves have dominated in ecotoxicological studies, and consequently spawned development into BEWSs: valve movements, typically measured using electromagnetic techniques; and bivalve cardiac activity, typically measured using infrared photoplethysmography. However, other, less studied bivalve behaviours may exhibit pollutant impacts, including shell growth and dissolution, premature egg/larval release, horizontal movement, and burial. Such metrics may, with further research, provide bases for future BEWSs, some through current valve movement monitoring technology, others potentially through acoustic telemetry. Future bivalve-based BEWSs may become more informative and sensitive through the greater nuance that lies in integration of different metrics simultaneously and/or multi-species monitoring. Future directions may seek techniques that reduce disturbance to bivalves and enable observation of a more natural mode of behaviour, through using untethered, or entirely unequipped, specimens. With rigorous controls for individual- and population-level variation, bivalves have great power as biosensors and, bolstered by the scope for future advancements, this field has the potential to make significant contributions to future water quality management.
Assessing the Time Dependence of AOPs on the Surface Properties of Polylactic Acid
Authors: Kalogirou Charalampia , Höfft Oliver , Gödde Anna , Papadimitriou Nikolaos , Pandis Pavlos K. , Argirusis Christos , Sourkouni Georgia 
Published: October 2022

AbstractPlastics are artificial synthetic organic polymers that have been used in every area of daily life. However, because of their slow degradation rate, their use is contentious. The treatment of the surface of the sample is considered necessary as enzymatic or bacterial attach is not possible if the plastic surface environment is not ideal. The main topic of this work is the investigation of the effect of different advanced oxidation processes (AOP) on the near surface structure of polylactic acid (PLA) samples, which, in turn, can promote the adhesion of enzymes or bacteria for further biodegradation. The Advanced Oxidation Processes that have been used are Ultrasonication, UV photodegradation and Dielectric Barrier Discharge (DBD) plasma. After the treatments, the surfaces were characterized by Infrared Spectroscopy (IR), Drop Contact Angle (DCA), Confocal Laser Scanning Microscopy (CLSM) and X-ray Photoelectron Spectroscopy (XPS). Both ultrasonic and UV treatments have a significant impact on the surface properties of immersed PLA by removing the oxygen-containing groups of the polymer chain, albeit in different ways, while plasma tends to uncover oxygen groups on the surface. The influence of the pre-treatment on improving the adhesion of bacteria on the PLA surface has been proven using a pseudomonas knackmussii strain.
Explanatory integration and integrated explanations in Darwinian medicine and evolutionary medicine
Authors: Kranke Nina 
Published: October 2022

AbstractRecently, two research traditions that bring together evolutionary biology and medicine, that is to say, Darwinian medicine and evolutionary medicine, have been identified. In this paper, I analyse these two research traditions with respect to explanatory and interdisciplinary integration. My analysis shows that Darwinian medicine does not integrate medicine and evolutionary biology in any strong sense but does incorporate evolutionary concepts into medicine. I also show that backward-looking explanations in Darwinian medicine are not integrated proximate-and-ultimate explanations but functional explanations that include reference to evolutionary concepts. Nevertheless, explanations in Darwinian medicine have heuristic roles as they potentially contribute to conceptual change and tie pieces of knowledge from different fields of medical research together. I argue that Darwinian medicine is an “interfield” that fosters cross-disciplinary exchange between evolutionary biologists and medical researchers and practitioners based on division of labour and separation, rather than unity. Research in evolutionary medicine, on the other hand, happens at the intersection of evolutionary biology and medicine where the two disciplines are already integrated and is designed to produce entangled proximate-evolutionary explanations. My analysis thus adds another important aspect to the philosophical discussion on the distinction between Darwinian medicine and evolutionary medicine.
Narrative Economics, Public Policy and Mental Health
Authors: Tubadji Annie , Boy Frédéric , Webber Don J. 
Published: October 2022

AbstractGeneral public’s mental health can be affected by the public policy response to a pandemic threat. Britain, Italy and Sweden have had very distinct approaches to the COVID-19 pandemic: early lock-down, delayed lock-down and no-lock-down. We develop a novel narrative economics of language Culture-Based Development approach, and using Google trend data for seed keywords, death and suicide, we reach two main conclusions: (i) while countries had a pre-existing culturally relative disposition towards death-related anxiety, the sensitivity to the public policy towards COVID-19 was also country specific; (ii) however, significant spillovers from one specific national lockdown public policy to another country’s mental health are identified.
Treatment patterns and survival of patients with locoregional recurrence in early-stage NSCLC: a literature review of real-world evidence
Authors: Bowes Kathleen , Jovanoski Nick , Brown Audrey E. , Di Maio Danilo , Belleli Rossella , Chadda Shkun , Abogunrin Seye 
Published: October 2022

AbstractApproximately 10–50% of patients treated for early-stage (I–III), resectable non-small cell lung cancer (eNSCLC) will develop locoregional recurrence. There is a lack of prospective trials evaluating optimal post-surgery follow-up for this patient population, and treatment guidelines recommend salvage therapies such as surgery, local ablative therapy, and (chemo)radiotherapy. A literature review was conducted according to pre-defined criteria to identify observational studies describing treatment patterns and survival outcomes in patients with eNSCLC who experienced locoregional recurrence. Results showed that, in real-world clinical practice, around 80% of patients with locoregional recurrence underwent any form of active treatment. The most frequently administered treatments were chemotherapy (35.7%), chemoradiotherapy (31.2%), radiotherapy (20.3%), and surgery alone (12.8%). Chemoradiotherapy was associated with improved PFS and OS compared with radiotherapy, while no statistically significant survival benefits were observed for patients receiving surgery in addition to these treatments. The overall survival of patients following treatment for locoregional recurrence was generally poor, and the proportion of patients who experienced any form of post-treatment re-recurrence ranged from 35 to 72%. These findings highlight the need to develop more effective treatment strategies for locoregional recurrence, including preventative treatments, and strategies to improve the survival outcomes of those who do develop locoregional recurrence.