bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hospital-wide cardiac arrest in situ simulation to identify and mitigate latent safety threats
Authors: Bentley Suzanne K. , Meshel Alexander , Boehm Lorraine , Dilos Barbara , McIndoe Mamie , Carroll-Bennett Rachel , Astua Alfredo J. , Wong Lillian , Smith Colleen , Iavicoli Laura , LaMonica Julia , Lopez Tania , Quitain Jose , Dube Guirlene , Manini Alex F. , Halbach Joseph , Meguerdichian Michael , Bajaj Komal 
Published: May 2022

Abstract
Background
Cardiac arrest resuscitation requires well-executed teamwork to produce optimal outcomes. Frequency of cardiac arrest events differs by hospital location, which presents unique challenges in care due to variations in responding team composition and comfort levels and familiarity with obtaining and utilizing arrest equipment. The objective of this initiative is to utilize unannounced, in situ, cardiac arrest simulations hospital wide to educate, evaluate, and maximize cardiac arrest teams outside the traditional simulation lab by systematically assessing and capturing areas of opportunity for improvement, latent safety threats (LSTs), and key challenges by hospital location.

Methods
Unannounced in situ simulations were performed at a city hospital with multidisciplinary cardiac arrest teams responding to a presumed real cardiac arrest. Participants and facilitators identified LSTs during standardized postsimulation debriefings that were classified into equipment, medication, resource/system, or technical skill categories. A hazard matrix was used by multiplying occurrence frequency of LST in simulation and real clinical events (based on expert opinion) and severity of the LST based on agreement between two evaluators.

Results
Seventy-four in situ cardiac arrest simulations were conducted hospital wide. Hundreds of safety threats were identified, analyzed, and categorized yielding 106 unique latent safety threats: 21 in the equipment category, 8 in the medication category, 41 in the resource/system category, and 36 in the technical skill category. The team worked to mitigate all LSTs with priority mitigation to imminent risk level threats, then high risk threats, followed by non-imminent risk LSTs. Four LSTs were deemed imminent, requiring immediate remediation post debriefing. Fifteen LSTs had a hazard ratio greater than 8 which were deemed high risk for remediation. Depending on the category of threat, a combination of mitigating steps including the immediate fixing of an identified problem, leadership escalation, and programmatic intervention recommendations occurred resulting in mitigation of all identified threats.

Conclusions
Hospital-wide in situ cardiac arrest team simulation offers an effective way to both identify and mitigate LSTs. Safety during cardiac arrest care is improved through the use of a system in which LSTs are escalated urgently, mitigated, and conveyed back to participants to provide closed loop debriefing. Lastly, this hospital-wide, multidisciplinary initiative additionally served as an educational needs assessment allowing for informed, iterative education and systems improvement initiatives targeted to areas of LSTs and areas of opportunity.
Metabolic profile analysis based on GC-TOF/MS and HPLC reveals the negative correlation between catechins and fatty acids in the cottonseed of Gossypium hirsutum
Authors: MA Lei , CHEN Yabing , XU Shuangjiao , DONG Ruidan , WANG Yiwen , FANG Dan , PENG Jun , TIAN Xinquan 
Published: May 2022

Abstract
Background
The diversified and high value-added utilization of cotton by products can promote the sustainable development of modern agriculture. Differences in potential nutrients among varieties can be explained by variations in the composition and abundance of fatty acids, polyphenols, carbohydrates, amino acids, and organic acids. Therefore, the analysis of metabolite species and relationships in cottonseed is meaningful for the development of cotton byproducts.

Results
In this study, the metabolomes of three representative cotton cultivars of different species were compared using untargeted GC-TOF/MS analysis. A total of 263 metabolites were identified from 705 peaks, and their levels were compared across cultivars. Principal component analysis and OPLS-DA clearly distinguish these samples based on metabolites. There were significant differences in the contents of amino acids, carbohydrates, organic acids, flavonoids, and lipids in G. hirsutum TM-1 compared with G. arboreum Shixiya1 and G. barbadense Hai7124. Notably, the bioactive nutrient compound catechin obtained from the differential metabolites significantly accumulated in TM-1. Furthermore, a comprehensive analysis using catechin and oil-related traits was conducted in core collections of Gossypium hirsutum. The results revealed the reliability of the GC-TOF/MS analysis, as well as that catechin content has a negative association with myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, arachidic acid, and total fatty acids.

Conclusion
These findings suggest that untargeted GC-TOF/MS analysis could provide a new method for investigating the underlying plant biochemistry of nutrient variation in cottonseed, and that catechin content has a negative association with oil-related traits in cottonseed. This study may pave the way to exploit the value of cotton byproducts.
Outcomes and prognostic factors of patients treated for in-stent restenosis: a retrospective single-center experience
Authors: Ghariani Anis , Ben Abdessalem Mohamed Aymen , Cheikh Sideya Khalil , Fekih Romdhane Ahmed , Ben Ameur Zied , Mosrati Hamza , Bouraoui Hatem , Mahdhaoui Abdallah , Jeridi Gouider 
Published: May 2022

Abstract
Background
The incidence of in-stent restenosis (ISR) remains relatively common despite the use of drug-eluting stents. Outcomes and prognostic factors following ISR revascularization are still being investigated. We aimed to describe the outcomes following different ISR treatment strategies in order to identify prognostic factors associated with worse outcomes.

Results
In a retrospective cohort study, we included patients who were admitted to our department and treated for ISR, from January 2017 to December 2018. All patients were followed up for a median period of 24 months. Major cardiac adverse event (MACE) was a composite outcome of the following events: myocardial infarction, target vessel revascularization, target lesion revascularization or cardiovascular death. MACEs were collected during follow-up. Our population consisted of 116 patients. Mean age was 60 years old with a sex ratio of 2.8. During follow-up, 44 patients (37.9%) had at least one MACE. Independent factors identified by multivariate logistic regression were ISR of the proximal left anterior descending artery [Odds ratio (OR) = 1.29; 95% confidence interval (95% CI) 1.16–1.81; p = 0.05], diffuse ISR [OR = 2.16; 95% CI 1.1–3.47; p = 0.022], double or triple vessel disease [OR = 2.97; 95% CI 1.2–6.8; p = 0.008], two or more stents per lesion [OR = 1.82; 95% CI 1.14–2.21, p = 0.031] and absence of post-dilatation in the initial angioplasty [OR = 1.32; 95% CI 1–1.35; p = 0.04].

Conclusions
Our study suggested that ISR is related to poor outcomes. Identifying prognostic factors would play a key role in the refinement of interventional techniques.
Impact of COVID-19 on digestive system: prevalence, clinical characteristics, outcome, and relation to the severity of COVID-19
Authors: Hashem Walaa M. , Abdelaziz Heba , Sallam Dina E. , Ismail Moamen Abdelfadil , Ahmed Ahmed Elmetwally 
Published: May 2022

Abstract
Background
Coronavirus disease 2019 (COVID-19) is commonly associated with respiratory symptoms. However, gastrointestinal (GI) symptoms are increasingly recognized in COVID-19 patients. The aim is to study the prevalence and features of gastrointestinal manifestations in severe acute respiratory coronavirus 2 (SARS-CoV-2) infected patients and evaluate the outcome among the studied population.

Results
We enrolled adult patients with laboratory-confirmed COVID-19 admitted to Ain Shams University designated hospitals, Cairo, Egypt, from March 2021 to June 2021. The patients were assigned to a GI group and a non-GI group based on the presence or absence of one or more digestive symptoms. A total of 300 hospitalized COVID-19 patients were included, of which 104 (34.7%) had one or more digestive symptoms. They were compared with 196 COVID-19 patients without GI symptoms. The most common reported GI symptom was diarrhea (82.7%). GI symptoms’ presence was higher in moderate cases. Patients with digestive symptoms presented for care later than those without (7.9±3.8 vs 7.4±7.2 days, P=0.5). Moreover, they have lower mortality, though non-significant (7.7 vs 12.8%, P=0.18). Patients with digestive symptoms had lower total leucocytic count (TLC), neutrophil count, neutrophil to lymphocyte ratio (NLR), platelet count, and higher serum sodium than those without digestive symptoms.

Conclusion
GI symptoms are prevalent among COVID-19 patients, and the most common was diarrhea. The presence of GI manifestations was not associated with increased mortality.
Effects of noise exposure among industrial workers in power plants of the National Electricity Company in N’Djamena, Chad
Authors: Taoussi Aboubakar Assidick , Yassine Abdel-sadick Abdallah , Malloum Mahamat Seïd Mahamat , Assi Constant , Fotclossou Tara , Ali Yusra Aboulbachar 
Published: May 2022

Abstract
Background
Noise pollution, unwanted or excessive sound, is one of the most common nuisances in industrial sectors. In the city of N’Djamena, Chad, workers in power plants are exposed to very high levels of noise, which could have deleterious effects on human health. The purpose of the study is to determine the level of noise pollution and its repercussions in a population of power plant workers.

Results
Ninety-two (11.5%) of the 800 workers were included. Their sex ratio was 88 men: 4 women with an outcome of 22. The age range was from 23 to 64 years with an average of 38.7 ± 9.0 years. Forty-seven (51.1%) of the employees had received occupational safety training. The average noise level in the machine rooms was 113.5 ± 4 dB(A). The average duration of exposure to noise was 10.8 ± 8.5 years. Personal protective equipment was worn regularly in 85.9% (n = 79). The consequences of noise pollution were auditory fatigue (38%; n = 35), tinnitus (32.6%; n = 30), hearing loss (15.2%; n = 14), nervousness (45.7%; n = 42), headache (33.7%; n = 31), raised voice (27.1%; n = 25), and insomnia (14.1%; n = 13).

Conclusions
The level of noise pollution is relatively high in power plants in N’Djamena, Chad. Hearing effects and an altered quality of life are observed among industrial workers. The acquisition of machines with regulated noise levels is desirable. The audiometric test should be integrated into the follow-up assessment of all employees.
A novel human activity recognition architecture: using residual inception ConvLSTM layer
Authors: Khater Sarah , Hadhoud Mayada , Fayek Magda B. 
Published: May 2022

AbstractHuman activity recognition (HAR) is a very challenging problem that requires identifying an activity performed by a single individual or a group of people observed from spatiotemporal data. Many computer vision applications require a solution to HAR. To name a few, surveillance systems, medical and health care monitoring applications, and smart home assistant devices. The rapid development of machine learning leads to a great advance in HAR solutions. One of these solutions is using ConvLSTM architecture. ConvLSTM architectures have recently been used in many spatiotemporal computer vision applications.In this paper, we introduce a new layer, residual inception convolutional recurrent layer, ResIncConvLSTM, a variation of ConvLSTM layer. Also, a novel architecture to solve HAR using the introduced layer is proposed. Our proposed architecture resulted in an accuracy improvement by 7% from ConvLSTM baseline architecture. The comparisons are held in terms of classification accuracy. The architectures are trained using KTH dataset and tested against both KTH and Weizmann datasets. The architectures are also trained and tested against a subset of UCF Sports Action dataset. Also, experimental results show the effectiveness of our proposed architecture compared to other state-of-the-art architectures.
Ideal Cardiovascular Health Metrics and Risk of Incident Early-Onset Vasomotor Symptoms Among Premenopausal Women
Authors: Choi Hye Rin , Chang Yoosoo , Kim Yejin , Cho Yoosun , Kang Jeonggyu , Kwon Min-Jung , Kwon Ria , Lim Ga-Young , Kim Kye-Hyun , Kim Hoon , Hong Yun Soo , Park Jihwan , Zhao Di , Cho Juhee , Guallar Eliseo , Park Hyun-Young , Ryu Seungho 
Published: May 2022

Abstract

Context
The relationship of ideal cardiovascular health (CVH) behaviors with preventing early-onset vasomotor symptoms (VMSs) is unknown.

Objective
We investigated the association between CVH metrics and the development of early-onset VMSs in premenopausal women.

Methods
This cohort study included 2541 premenopausal women aged 42 to 52 years without VMSs at baseline. CVH metrics were defined according to the American Heart Association Life Simple 7 metrics. Owing to limited availability of dietary information, CVH metrics were scored from 0 (unhealthy) to 6 (healthy) and classified into 3 groups: poor (0-2), intermediate (3-4), and ideal (5-6) CVH. VMSs, including hot flashes and night sweats, were assessed using the Menopause-Specific Quality of Life questionnaire. Moderate/severe VMSs was defined as a score of 3 or more points (range, 0 to 6; 6 being most bothersome).

Results
During a median follow-up of 4.5 years, 1241 women developed VMSs before menopause. After adjustment for age, parity, education level, and alcohol consumption, the hazard ratio (HR) (95% CI) for developing early-onset VMSs comparing poor CVH group to the ideal group was 1.41 (1.07-1.86). CVH scores were also inversely associated with moderate/severe VMSs in a dose-response manner (P for trend = .004); specifically, multivariable-adjusted HRs comparing intermediate and poor CVH groups to the ideal group were 1.20 (95% CI, 1.02-1.43) and 1.57 (95% CI, 1.08-2.29), respectively.

Conclusion
Unfavorable CVH metrics were significantly associated with an increased risk of early-onset VMSs and its more severe forms among premenopausal women.
Pleiotropic Actions of PGRMC Proteins in Cancer
Authors: Pru James K 
Published: May 2022

AbstractProgesterone receptor membrane component (PGRMC) proteins play important roles in tumor growth, progression, and chemoresistance, of which PGRMC1 is the best characterized. The ancestral member predates the evolution of metazoans, so it is perhaps not surprising that many of the purported actions of PGRMC proteins are rooted in fundamental metabolic processes such as proliferation, apoptosis, and DNA damage responses. Despite mediating some of the actions of progesterone (P4) and being fundamentally required for female fertility, PGRMC1 and PGRMC2 are broadly expressed in most tissues. As such, these proteins likely have both progesterone-dependent and progesterone-independent functions. It has been proposed that PGRMC1 acquired the ability to mediate P4 actions over evolutionary time through acquisition of its cytochrome b5-like heme/sterol-binding domain. Diverse reproductive and nonreproductive diseases associate with altered PGRMC1 expression, epigenetic regulation, or gene silencing mechanisms, some of which include polycystic ovarian disease, premature ovarian insufficiency, endometriosis, Alzheimer disease, and cancer. Although many studies have been completed using transformed cell lines in culture or in xenograft tumor approaches, recently developed transgenic model organisms are offering new insights in the physiological actions of PGRMC proteins, as well as pathophysiological and oncogenic consequences when PGRMC expression is altered. The purpose of this mini-review is to provide an overview of PGRMC proteins in cancer and to offer discussion of where this field must go to solidify PGRMC proteins as central contributors to the oncogenic process.
Relationships between changes in EEG and some metabolic parameters in patients of Truskavets’ spa
Authors: Kushneruk Anatoliy , Popovych Dariya , Żukow Xawery , Zakalyak Nataliya , Popovych Igor 
Published: May 2022

Background. Earlier, we found relationships between EEG/HRV parameters and plasma/ urine electrolytes concentration in Truskavets’ spa patients. The aim of this study is to analyze the relationships between changes in these parameters under the influence of balneotherapy. Materials and Methods. The object of observation were 22 men (23-70 years), who underwent rehabilitation treatment of chronic pyelonephritis and cholecystitis in remission. The examination was performed twice, before and after a 9-11-day course of balneotherapy. The object of the study were the parameters of the EEG and exchange of electrolytes and nitric metabolites. Results. Judging by the coefficient of determination, changes in the concentrations of electrolytes and nitric metabolites in the urine and plasma are mediated by changes in neurodynamics by 99,8 % and 99,4% respectively. Conclusion. Balneotherapy affects the exchange of electrolytes and nitrogen metabolites through the CNS.
Locating the unique biodiversity of Balikpapan Bay as an ecotourism attraction in East Kalimantan, Indonesia
Authors: Willard Karnila , Aipassa Marlon I , Sardjono Mustofa Agung , RUJEHAN Rujehan , RUSLIM YOSEP , Kristiningrum Rochadi 
Published: May 2022

Abstract. Willard K, Aipassa MI, Sardjono MA, Rujehan, Ruslim Y, Kristiningrum R. 2022. Locating the unique biodiversity of Balikpapan Bay as an ecotourism attraction in East Kalimantan, Indonesia. Biodiversitas 23: 2342-2357. Balikpapan Bay is rich in biodiversity and natural beauty that present unique opportunities for the developing ecotourism industry in East Kalimantan, Indonesia. This study aimed to identify biodiversity hotspots with potential as ecotourism attractions. Four field surveys by boat, each survey taking between 10 to 22 hours duration, tracked the river and tidal flow through the Bay, recording highlights of biodiversity at 19 defined observation points. The study results recorded observations on five species listed in the IUCN protected species classification, namely: Lesser Adjutant Stork (Leptoptilos javanicus) - classified as a Vulnerable species; Proboscis Monkey (Nasalis larvatus), Irrawaddy Dolphin (Orcaella brevirostris) and Green Turtle (Chelonia mydas) - classified as Endangered species; and the Hawksbill Turtle (Eretmochelys imbricata) - classified as Critically Endangered. In addition, details were recorded of a unique variant of the mangrove species Rhizophora apiculata, with leaves that have a vibrant yellow color instead of the usual green. Combined with great views, including at night when there are enchanting displays of Fireflies (Lampyridae) on several riverbanks, the biodiversity of the waterways results in Balikpapan Bay having great potential as an ecotourism destination. Therefore, this study provides useful input to relevant agencies charged with responsibility for conserving and managing the natural resources of the Bay for the benefit of communities who stand to gain economically from developing this ecotourism potential.
Molecular phylogeny of anchovy (Clupeiformes: Clupeidae) from southern waters of Lombok using mitochondrial DNA CO1 gene sequences
Authors: MAHRUS H. , AL IDRUS AGIL , ZULKIFLI LALU 
Published: May 2022

Abstract. Mahrus H, Idrus AA, Zulkifli L. 2022. Molecular phylogeny of anchovy (Clupeiformes: Clupeidae) from southern waters of Lombok using mitochondrial DNA CO1 gene sequences. Biodiversitas 23: 2433-2443. This study aimed to identify anchovy samples genetically and evaluate their phylogenetic relationship to anchovies using the CO1 genetics markers. Fragment amplification of COI gene anchovy used a pair of COI commercially available primer with a length amplicon of about 693 base pairs (bp), coding for 231 amino acids successfully. The reconstruction of the phylogenetic tree with the neighbor-joining (NJ) method using Kimura 2 Parameters (K2P) by employing a bootstrap of 1000 replications. The genetic distance analysis between 19 fishes species in different families and 13 species in the genera Spartelloides acceded from NCBI indicated the closest distance between anchovy samples from the southern waters of Lombok and Spratelloides delicatulus from Australia is 0.02. The comparisons results of homology with the NCBI and the BOLD database show the anchovy sample has similarities to the CO1 sequences of S. delicatulus with a similar of 99%. The results of the phylogenetic tree analysis showed that the anchovy samples from the southern waters of Lombok were in the same clade as S. delicatulus from Australia. The study concluded a fish sample of anchovy from the southerly waters of Lombok was a closed related species to S. delicatulus.
Diversity of leaf rust resistance in Indonesian sorghum genetic resources
Authors: DINANTY FAWWAZ , WIRNAS DESTA , TRIKOESOEMANINGTYAS TRIKOESOEMANINGTYAS , NAWANGSIH ABDJAD ASIH 
Published: May 2022

Abstract. Dinanty F, Wirnas D, Trikoesoemaningtyas, Nawangsih AA. 2022. Diversity of leaf rust resistance in Indonesian sorghum genetic resources. Biodiversitas 23: 2570-2579. Sorghum is an alternative source as a substitute for rice. Leaf rust (Puccinia purpurea) is a constraint in sorghum cultivation and resistance to rust disease is a condition for releasing sorghum varieties. This study aimed to screen sorghum accessions for resistance to leaf rust disease. The screening was carried out on 48 sorghum accessions and seven check varieties, namely Numbu, Kawali, Bioguma 1, Pahat, Soraya 1, Soraya 2, and Soraya 3. Evaluation of leaf rust resistance under field conditions was carried out in IPB University experimental field Cikarawang-Bogor (275 asl) from February 2021 to June 2021. The experiment was conducted in an augmented design with four replications for check varieties. Identification of leaf rust resistance was also carried out using molecular markers designed from the Lr34 and Rp1D genes. The results revealed that 5 genotypes, namely genotypes 31 (Demak 2), 24 (IS 18551), 43 (Lokal bima 3), 17 (ICSV 93036), and 33 (Demak 5) were resistant to leaf rust with high yield potential. The results of identification using molecular markers showed that all accessions had Lr34 and Rp1D gene fragments.
Genetic diversity of rosewood (Dalbergia latifolia) in Yogyakarta, Indonesia for plus trees selection
Authors: RIASTIWI INDIRA , WITJAKSONO WITJAKSONO , RATNADEWI DIAH , SIREGAR ULFAH JUNIARTI 
Published: May 2022

Abstract. Riastiwi I, Witjaksono, Ratnadewi D, Siregar UJ. 2022. Genetic diversity of rosewood (Dalbergia latifolia) in Yogyakarta, Indonesia for plus trees selection. Biodiversitas 23: 2630-2639. Rosewood (Dalbergia latifolia Roxb.) or sonokeling is an important woody plant species with a high selling value. However, due to overexploitation, this species has been listed in Appendix II of CITES and its trade is strictly regulated. Therefore, the cultivation of this plant needs encouragement, and superior planting materials from selected plus trees are needed. This study aimed to examine the genetic diversity of the rosewood population and select plus trees in Yogyakarta Province, Indonesia. The plus tree selection was performed by comparing plus tree candidates with five other trees nearby in four districts, i.e. Bantul, Gunungkidul, Kulon Progo, and Sleman. As many as 61 plus tree candidates have been identified. Genetic diversity was assessed using 10 selected ISSR primers, resulting in 101 ISSR loci with average Polymorphic Loci values ??of 64.71% and Nei Heterozygosity of 0.23. The highest gene diversity (He=0.29) was found in the Kulon Progo population, and the lowest He=0.17 was in the Bantul population. The dendogram and PCA analysis put Gunungkidul and Bantul populations into one group, separated from the Sleman and Kulon Progo populations. Based on morphological and molecular analysis, six superior plus trees were obtained.