bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitral regurgitation quantification by cardiac magnetic resonance imaging (MRI) remains reproducible between software solutions
Authors: Grafton-Clarke Ciaran , Thornton George , Fidock Benjamin , Archer Gareth , Hose Rod , van der Geest Rob J. , Zhong Liang , Swift Andrew J. , Wild James M. , De Gárate Estefania , Bucciarelli-Ducci Chiara , Plein Sven , Treibel Thomas A. , Flather Marcus , Vassiliou Vassilios S. , Garg Pankaj 
Published: January 2022

Background: The reproducibility of mitral regurgitation (MR) quantification by cardiovascular magnetic resonance (CMR) imaging using different software solutions remains unclear. This research aimed to investigate the reproducibility of MR quantification between two software solutions: MASS (version 2019 EXP, LUMC, Netherlands) and CAAS (version 5.2, Pie Medical Imaging). Methods: CMR data of 35 patients with MR (12 primary MR, 13 mitral valve repair/replacement, and ten secondary MR) was used. Four methods of MR volume quantification were studied, including two 4D-flow CMR methods (MRMVAV and MRJet) and two non-4D-flow techniques (MRStandard and MRLVRV). We conducted within-software and inter-software correlation and agreement analyses. Results: All methods demonstrated significant correlation between the two software solutions: MRStandard (r=0.92, p<0.001), MRLVRV (r=0.95, p<0.001), MRJet (r=0.86, p<0.001), and MRMVAV (r=0.91, p<0.001). Between CAAS and MASS, MRJet and MRMVAV, compared to each of the four methods, were the only methods not to be associated with significant bias. Conclusions: We conclude that 4D-flow CMR methods demonstrate equivalent reproducibility to non-4D-flow methods but greater levels of agreement between software solutions.
RealTE: Real-time Trajectory Estimation Over Large-Scale Road Networks
Authors: Zhou Qibin , Su Qingang , Yang Dingyu 
Published: January 2022

Real-time traffic estimation focuses on predicting the travel time of one travel path, which is capable of helping drivers selecting an appropriate or favor path. Statistical analysis or neural network approaches have been explored to predict the travel time on a massive volume of traffic data. These methods need to be updated when the traffic varies frequently, which incurs tremendous overhead. We build a system RealTER⁢e⁢a⁢l⁢T⁢E, implemented on a popular and open source streaming system StormS⁢t⁢o⁢r⁢m to quickly deal with high speed trajectory data. In RealTER⁢e⁢a⁢l⁢T⁢E, we propose a locality-sensitive partition and deployment algorithm for a large road network. A histogram estimation approach is adopted to predict the traffic. This approach is general and able to be incremental updated in parallel. Extensive experiments are conducted on six real road networks and the results illustrate RealTE achieves higher throughput and lower prediction error than existing methods. The runtime of a traffic estimation is less than 11 seconds over a large road network and it takes only 619619 microseconds for model updates.
Pengaruh Deklinasi Matahari terhadap parameter cuaca wilayah malang dan sekitarnya
Authors: Sasmito Achmad , Praja Alfan Sukmana , Muzayanah Linda Fitrotul , Sudewi Rahayu Sapta sri 
Published: January 2022

<p class="AbstractText">Suhu udara dingin terjadi di dataran tinggi Dieng dan Lumajang pada akhir Juli hingga Agustus 2020. Pada saat yang hampir bersamaan, suhu udara panas terjadi pula di Amerika Serikat, Jepang, dan Spanyol. Penelitian ini membahas pengaruh deklinasi matahari terhadap parameter cuaca di Malang dan sekitarnya. Selain itu, dibahas juga tinjauan fisis dan dinamis terjadinya suhu udara panas di Bumi bagian utara (BBU) dengan suhu udara dingin di bumi bagian selatan (BBS). Data yang digunakan yaitu data numerik radiasi matahari di atmosfer dan data observasi dari AWS yang meliputi unsur radiasi global, suhu, dan kelembapan udara permukaan. Sampel data diambil dari stasiun Klimatologi Malang dan Stasiun Geofisika Karang Kates yang mewakili BBS dan informasi cuaca dari BBU. Estimasi suhu dingin di Ranu Pani, Lumajang dilakukan dengan menggunakan model lapserate. Suhu dingin yang terjadi di wilayah jawa timur dipengaruhi oleh deklinasi matahari, radiasi matahari, koefisien transmisivitas dan proses adveksi suhu dari Australia. Saat matahari berada di utara, terjadi suhu dingin di bumi bagian selatan dan sebaliknya. Terjadinya suhu panas atau dingin di setiap wilayah dipengaruhi juga oleh komposisi gas di atmosfer, geografi, topografi, dan pengaruh adveksi karena pengaruh udara di sekitarnya.</p>
Chucotos sin fronteras. La suerte de un ciclo de chistes ruso fuera de Rusia
Authors: Castañar Rubio Guillem 
Published: January 2022

Los chucotos son un pueblo minoritario de la península de Chukotka, en el noreste de la Federación de Rusia. En la segunda mitad del siglo pasado, empezaron a ser objeto de burla en chistes en lengua rusa y, en poco tiempo, se convirtieron en uno de los blancos favoritos del humor étnico soviético. Sin embargo, la fama de este productivo ciclo no quedó circunscrita a las fronteras de Rusia. Aunque trabajos previos (Castañar 2021) han demostrado que, en la etapa postsoviética, la caracterización de estos personajes no cambió en Rusia, no se ha estudiado qué ocurrió en otros países donde este ciclo también se popularizó. El presente artículo aborda la evolución de los chistes étnicos postsocialistas[1] sobre chucotos fuera del espacio lingüístico ruso, más concretamente, en Estonia.

[1] Período de transición siguiente al socialismo que afectó a Europa Central, los Balcanes y la Unión Soviética, y que abarca la década de los noventa del siglo xx (v. Hann 1994).
The hub of the system. Discussions and perceptions regarding the geopolitical role of Milan in the 16th century
Authors: Rizzo Mario 
Published: January 2022

The article studies the geopolitical role of the State of Milan during the 16th century, as it was perceived and discussed by both members of the Habsburg ruling class as well as Italian writers, politicians and diplomats who did not belong to those circles nor were under their influences. The analysis starts with the early years of the century and subsequently covers the period of the Wars of Italy and then the second half of the century, when the new international context created by the peace of Cateau Cambrésis gave rise to a complex interplay between continuity and change.
Keywords: geopolitics, 16th-century Italy, Milan, Habsburg Empire.
Geometric effects of plasmonic nanoscale heterostructures on infrared activity
Authors: Roper D. Keith , Thomson Caleb J. 
Published: January 2022

Electron probes can resolve bright and dark optical modes at subwavelength scales to distinguish localized effects, e.g., those of composition and geometry, via energy loss measurements. In this work, electron energy loss spectra of a metal nanospheroid (NS) near a van der Waals material were simulated to show effects of NS shape and structure on plasmon and exciton energies. Hollowing or elongating the NS intensified and shifted its plasmon bright and dark mode energy losses. Simultaneous hollowing and elongation intensified and redshifted bifurcated bright modes more than adding effects of separate alterations, whereas the dark mode intensified additively and redshifted subadditively. Proximity to a transition metal dichalcogenide (TMD) nanodisk differentiated redshifting of bright modes (more) and dark (less) modes and fractured the modes across multiple spectral features. Some bright and dark mode energies were pinned at TMD exciton energies. Measured optical spectra exhibiting such effects corresponded to simulation. Only simultaneous hollowing and elongation above a TMD nanodisk redshifted primary components of each bright and dark mode entirely into the near-infrared (NIR) biological water window. Simulating energy electron loss spectra identifies nanoheterostructure geometry and composition that enhances bright- and dark-mode activity at biologically transparent NIR energies to potentiate bio/catalytic activity.
Comparative study of different optimization methods for single attosecond pulse generation with a two- or three-color gating scheme
Authors: Yang Ke , Du Jin-Xu , Wang Guo-Li , Jiao Zhi-Hong , Zhao Song-Feng , Zhou Xiao-Xin 
Published: January 2022

The shaping of the waveform of a two- or three-color driving laser pulse is essential for generating an ultrashort isolated attosecond pulse (IAP) from high-order harmonic generation, which can be implemented in two different ways, i.e., direct coherent synthesizing of electric fields with appropriate parameters (wavelength, intensity, carrier envelope phase, time delay), and superposition of fields undergoing a spectral phase shaping in frequency space view, which additionally results in a chirp and pulse-width broadening. In this work, we perform a comparative study on the IAP generation with these two schemes by virtue of a genetic algorithm, and two very meaningful conclusions are clarified. First, weighing the advantages and disadvantages of the two methods, the width and strength of IAPs optimized from two schemes are basically the same. More optimization parameters in the second method of laser shaping do not show an advantage in shortening width or enhancing the intensity of the IAP compared with the first one. Second, in each case, one can get the shortest IAP when the carrier envelope phases for each spectral component are not required to be precisely controlled. This study provides useful theoretical guidance for generating a shorter IAP with multicolor gating in the experiment.
Efficiency adjustable terahertz circular polarization anomalous refraction and planar focusing based on a bi-layered complementary Z-shaped graphene metasurface
Authors: Zhu Xuzheng , Cheng Yongzhi , Chen Fu , Luo Hui , Ling Wu 
Published: January 2022

Metasurfaces (MSs) have received great attention due to their wide application potentials in terahertz (THz) wavefront manipulation. Although great achievements have been obtained in MSs so far, the functionalities are almost static. The active adjustable MS-based devices are far less explored. In this paper, an efficiency adjustable MS composed of a dielectric substrate sandwiched with bi-layered complementary Z-shaped (CZS) structure graphene is proposed and investigated theoretically, which can control the THz circular polarization (CP) wavefront in transmission mode. The simulation results show that the MS structure under a Fermi energy level of 1.0 eV can realize CP conversion with efficiency of about 0.9, and the full range of a

2

π

phase shift also can be achieved by changing the rotation angle of the CZS structure graphene along the wave propagation direction. More importantly, the transmission CP conversion efficiency is positively correlated with the Fermi energy levels of graphene. The anomalous refraction and planar focusing effect can be realized by the specific design of a spatial phase profile of the graphene MS, and the corresponding efficiencies can be adjusted by changing the Fermi energy level of the graphene. Adjustable graphene MSs have wide application prospects in the fields of communication, imaging, and other THz wavefront manipulation devices.
Association of serum 25-hydroxyvitamin D concentrations with risk of dementia among individuals with type 2 diabetes: A cohort study in the UK Biobank
Authors: Geng Tingting , Lu Qi , Wan Zhenzhen , Guo Jingyu , Liu Liegang , Pan An , Liu Gang 
Published: January 2022

BackgroundSeveral epidemiological studies have suggested that vitamin D status is associated with risk of dementia in general populations. However, due to the synergistic effect between diabetic pathology and neuroinflammation, and the prothrombotic profile in patients with diabetes, whether vitamin D is associated with risk of dementia among patients with diabetes is unclear. This study aimed to investigate the associations of circulating vitamin D levels with risks of all-cause dementia, Alzheimer disease (AD), and vascular dementia (VD) among adults with type 2 diabetes (T2D).Methods and findingsThis study included 13,486 individuals (≥60 years) with T2D and free of dementia at recruitment (2006–2010) from the UK Biobank study. Serum 25-hydroxyvitamin D (25[OH]D) concentrations were measured using the chemiluminescent immunoassay method at recruitment. Serum 25(OH)D ≥ 75 nmol/L was considered sufficient, according to the Endocrine Society Clinical Practice Guidelines. Incidence of all-cause dementia, AD, and VD cases was ascertained using electronic health records (EHRs). Each participant’s person-years at risk were calculated from the date of recruitment to the date that dementia was reported, date of death, date of loss to follow-up, or 28 February 2018, whichever occurred first. Among the 13,486 individuals with T2D (mean age, 64.6 years; men, 64.3%), 38.3% had vitamin D ≥ 50 nmol/L and only 9.1% had vitamin D ≥ 75 nmol/L. During a mean follow-up of 8.5 years, we observed 283 cases of all-cause dementia, including 101 AD and 97 VD cases. Restricted cubic spline analysis demonstrated a nonlinear relationship between serum 25(OH)D and risk of all-cause dementia (Pnonlinearity< 0.001) and VD (Pnonlinearity= 0.007), and the nonlinear association reached borderline significance for AD (Pnonlinearity= 0.06), with a threshold at around a serum 25(OH)D value of 50 nmol/L for all the outcomes. Higher serum levels of 25(OH)D were significantly associated with a lower risk of all-cause dementia, AD, and VD. The multivariate hazard ratios and 95% confidence intervals for participants who had serum 25(OH)D ≥ 50 nmol/L, compared with those who were severely deficient (25[OH]D < 25 nmol/L), were 0.41 (0.29–0.60) for all-cause dementia (Ptrend< 0.001), 0.50 (0.27–0.92) for AD (Ptrend= 0.06), and 0.41 (0.22–0.77) for VD (Ptrend= 0.01). The main limitation of the current analysis was the potential underreporting of dementia cases, as the cases were identified via EHRs.ConclusionsIn this study, we observed that higher concentrations of serum 25(OH)D were significantly associated with a lower risk of all-cause dementia, AD, and VD among individuals with T2D. Our findings, if confirmed by replication, may have relevance for dementia prevention strategies that target improving or maintaining serum vitamin D concentrations among patients with T2D.
Occurrence of L1014F and L1014S mutations in insecticide resistant Culex quinquefasciatus from filariasis endemic districts of West Bengal, India
Authors: Rai Priyanka , Saha Dhiraj 
Published: January 2022

Introduction
Lymphatic filariasis causes long term morbidity and hampers the socio-economic status. Apart from the available treatments and medication, control of vector population Culex quinquefasciatus Say through the use of chemical insecticides is a widely applied strategy. However, the unrestrained application of these insecticides over many decades has led to resistance development in the vectors.

Methods
In order to determine the insecticide susceptibility/resistance status of Cx. quinquefasciatus from two filariasis endemic districts of West Bengal, India, wild mosquito populations were collected and assayed against six different insecticides and presence of L1014F; L1014S kdr mutations in the voltage-gated sodium channel gene was also screened along with the use of synergists to evaluate the role of major detoxifying enzymes in resistance development.

Results
The collected mosquito populations showed severe resistance to insecticides and the two synergists used–PBO (piperonyl butoxide) and TPP (triphenyl phosphate), were unable to restore the susceptibility status of the vector thereupon pointing towards a minor role of metabolic enzymes. kdr mutations were present in the studied populations in varying percent with higher L1014F frequency indicating its association with the observed resistance to pyrethroids and DDT. This study reports L1014S mutation in Cx. quinquefasciatus for the first time.
Effects of adipose-derived stromal cells and endothelial progenitor cells on adipose transplant survival and angiogenesis
Authors: Gan Fengshan , Liu Liu , Zhou Qingzhu , Huang Wenli , Huang Xinwei , Zhao Xian 
Published: January 2022

Background
A paracrine mechanism is thought to mediate the proangiogenic capacity of adipose-derived stromal/stem cells (ASCs). However, the precise mechanism by which ASCs promote the formation of blood vessels by endothelial progenitor cells (EPCs) is unclear.

Methods
The EPCs-ASCs cocultures prepared in different ratios were subjected to tube formations assay to verify whether ASCs could directly participate in the tube genesis. The supernatant from cultured ASCs was used to stimulate EPCs to evaluate the effects on the angiogenic property of EPCs, as well as capacity for migration and invasion. A coculture model with transwell chamber were used to explore the regulation of angiogenesis markers expression in EPCs by ASCs. We then mixed ASCs with EPCs and transplanted them with adipose tissue into nude mice to evaluate the effects on angiogenesis in adipose tissue grafts.

Results
In the EPCs-ASCs cocultures, the tube formation was significantly decreased as the relative abundance of ASCs increased, while the ASCs was found to migrate and integrated into the agglomerates formed by EPCs. The supernatant from ASCs cultures promoted the migration and invasion of EPCs and the ability to form capillary-like structures. The expression of multiple angiogenesis markers in EPCs were significantly increased when cocultured with ASCs. In vivo, ASCs combined with EPC promoted vascularization in the fat transplant. Immunofluorescence straining of Edu and CD31 indicated that the Edu labeled EPC did not directly participate in the vascularization inside the fat tissue.

Conclusions
ADSC can participate in the tube formation of EPC although it cannot form canonical capillary structures. Meanwhile, Soluble factors secreted by ASCs promotes the angiogenic potential of EPCs. ASCs paracrine signaling appears to promote angiogenesis by increasing the migration and invasion of EPCs and simultaneously upregulating the expression of angiogenesis markers in EPCs. The results of in vivo experiments showed that ASCs combined with EPCs significantly promote the formation of blood vessels in the fat implant. Remarkably, EPCs may promote angiogenesis by paracrine regulation of endogenous endothelial cells (ECs) rather than direct participation in the formation of blood vessels.
A model for sustainable, partnership-based telehealth services in rural India: An early process evaluation from Tuver village, Gujarat
Authors: Ramanadhan Shoba , Ganapathy Krishnan , Nukala Lovakanth , Rajagopalan Subramaniya , Camillus John C. 
Published: January 2022

Background
Telehealth can improve access to high-quality healthcare for rural populations in India. However, rural communities often have other needs, such as sanitation or employment, to benefit fully from telehealth offerings, highlighting a need for systems-level solutions. A Business of Humanity approach argues that innovative solutions to wicked problems like these require strategic decision-making that attends to a) humaneness, e.g., equity and safety and b) humankind, or the needs and potential of large and growing markets comprised of marginalized and low-income individuals. The approach is expected to improve economic performance and long-term value creation for partners, thus supporting sustainability.

Methods
A demonstration project was conducted in Tuver, a rural and tribal village in Gujarat, India. The project included seven components: a partnership that emphasized power-sharing and complementary contributions; telehealth services; health promotion; digital services; power infrastructure; water and sanitation; and agribusiness. Core partners included the academic partner, local village leadership, a local development foundation, a telehealth provider, and a design-build contractor. This early process evaluation relies on administrative data, field notes, and project documentation and was analyzed using a case study approach.

Results
Findings highlight the importance of taking a systems perspective and engaging inter-sectoral partners through alignment of values and goals. Additionally, the creation of a synergistic, health-promoting ecosystem offers potential to support telehealth services in the long-term. At the same time, engaging rural, tribal communities in the use of technological advances posed a challenge, though local staff and intermediaries were effective in bridging disconnects.

Conclusion
Overall, this early process evaluation highlights the promise and challenges of using a Business of Humanity approach for coordinated, sustainable community-level action to improve the health and well-being of marginalized communities.
Suicidal behaviors among Bangladeshi university students: Prevalence and risk factors
Authors: Rasheduzzaman M. , al-Mamun Firoj , Hosen Ismail , Akter Tahmina , Hossain Moazzem , Griffiths Mark D. , Mamun Mohammed A. 
Published: January 2022

BackgroundBangladeshi university students are considered to be highly suicide-prone compared to other populations and cohorts. However, no prior epidemiological studies have assessed the suicidality (i.e., past-year suicidal ideation [SI], lifetime suicide plan [SP], and lifetime suicide attempt [SA]) among Bangladeshi students, including the variables such as past-year stressful life events and family mental health history. This is arguably a major knowledge gap in the country. Therefore, the present study investigated the prevalence and associated risk factors for suicidal behaviors among Bangladeshi university students.MethodsA cross-sectional study was conducted utilizing a convenience sampling method among a total of 1844 university students between October and November 2019. Data were collected based on the information related to socio-demographics, perceived health-related questions, past-year stressful life events, family mental health history, and suicidal behaviors (i.e., SI, SP, and SA). Chi-square tests and binary logistic regressions were used to analyze the data utilizing SPSS statistical software.ResultsThe prevalence of past-year suicidal ideation, lifetime suicide plans, and suicide attempts were 13.4%, 6.0%, and 4.4%, respectively. Females reported significantly higher suicidal behavior than males (i.e., 20.6% vs.10.2% SI; 9% vs. 4.6% SP; and 6.4% vs.3.6% SA). Risk factors for SI were being female, year of academic study, residing in an urban area, using psychoactive substances, experiencing both past year physical and mental illness, experiencing any type of stressful past-year life events, experiencing campus ragging (i.e., senior students abusing, humiliating and/or harassing freshers or more junior students), experiencing family mental illness history, and having family suicide attempt history. SP was associated with several factors including being female, year of academic study, using psychoactive substance, experiencing both past-year physical and mental illness, and experiencing any type of stressful past-year life events. Risk factors for SA were being female, year of academic study, using psychoactive substances, experiencing past-year mental illness, experiencing any type of stressful past-year life events, and having family suicide attempt history.ConclusionsUniversity students appear to be a vulnerable group for experiencing suicidal behaviors. The present findings warrant rigorous action and early intervention programs such as counseling and other mental health professional services by university authorities. Longitudinal studies are highly recommended involving countrywide representative samples.