bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporary hypotension and ventilation difficulty during endoscopic injection sclerotherapy for esophageal varices in a child with Fontan circulation: a case report
Authors: Yasutomi Nanako , Shimizu Tatsuhiko , Kanazawa Tomoyuki , Shimizu Kazuyoshi , Iwasaki Tatsuo , Morimatsu Hiroshi 
Published: July 2022

Abstract
Background
Endoscopic procedures are rarely performed in children with congenital heart disease (CHD); therefore, the associated complications are unknown. We report an abrupt change in circulatory and respiratory condition during endoscopic injection sclerotherapy for esophageal varices.

Case presentation
A 9-year-old boy with a history of total anomalous pulmonary venous connection (TAPVC) repair and Fontan procedure for asplenia and a single ventricle with TAPVC underwent endoscopic injection sclerotherapy under general anesthesia for esophageal varices. Systolic blood pressure decreased from 70 to 50 mmHg following a sclerosant injection; a second injection reduced his peripheral oxygen saturation from 93 to 79% secondary to ventilation difficulty. Although we suspected anaphylaxis intraoperatively, postoperative imaging suggested that balloon dilation performed to prevent sclerosing agent leakage caused compression of the pulmonary venous chamber and trachea owing to the anomalous intrathoracic organ anatomy.

Conclusion
Thorough understanding of the complex anatomy is important before performing endoscopic procedures in children with CHD to preoperatively anticipate possible intraoperative complications and select the optimal therapeutic approach and anesthesia management.
Experimental measurement of the exclusion-diffusion potential in sandstone and shaly sand samples at full and partial water saturation
Authors: Alarouj Mutlaq , Jackson Matthew David 
Published: July 2022

The exclusion-diffusion potential (EDP) arises in response to concentration gradients and is one of the key components of the self-potential (SP) observed in subsurface environments. However, few data are available to characterize the EDP in reservoir rocks saturated with complex natural brines and at partial brine saturation. We report experimental measurements of the EDP across fully and partially brine-saturated sandstone samples and fully brine-saturated shaly sand samples, using natural saline brine (2.2 Mol/L), seawater (0.5 Mol/L), and natural crude oil. When fully saturated, the EDP across the samples is diffusion-dominated, with the shaly samples exhibiting a small contribution from charge exclusion. The contribution of charge exclusion to the measured EDP increases as permeability decreases. At the residual oil saturation, the measured EDP is diffusion-dominated, consistent with our findings at full saturation. However, the EDP is more exclusive at the irreducible water saturation, and the polarity of the excluded ions depends on the polarity of the charged oil-brine interface. A charge exclusion is more significant at lower irreducible water saturation. Our results support recent studies suggesting that the oil-brine interface can be positively charged in contact with natural brines. The EDP trends reported have not been observed previously and have broad implications for geophysical monitoring of subsurface flow and transport, such as transport of nonaqueous phase contaminants in aquifers and water flow during hydrocarbon production.
Triglyceride Metabolism Modifies Lipoprotein(a) Plasma Concentration
Authors: Ramos-Cáceres Maria , Lamiquiz-Moneo Itziar , Cenarro Ana , Calmarza Pilar , Marco-Benedí Victoria , Bea Ana M , Mateo-Gallego Rocio , Puzo Jose , Ordovas Jose M , Civeira Fernando , Laclaustra Martin 
Published: July 2022

AbstractBackgroundLipoprotein(a) (Lp(a)) is a significant cardiovascular risk factor. Knowing the mechanisms that regulate its concentration can facilitate the development of Lp(a)-lowering drugs. This study analyzes the relationship between triglycerides (TGs) and Lp(a) concentrations, cross-sectionally and longitudinally, and the influence of the number and composition of TG-rich lipoproteins, and the APOE genotype.MethodsData from Aragon Workers Health Study (AWHS) (n = 5467), National Health and Nutrition Examination Survey III phase 2 (n = 3860), and Hospital Universitario Miguel Servet (HUMS) (n = 2079) were used for cross-sectional TG and Lp(a) relationship. Lp(a) intrasubject variation was studied in AWHS participants and HUMS patients with repeated measurements. TG-rich lipoproteins were quantified by nuclear magnetic resonance in a subsample from AWHS. Apolipoproteins B and E were quantified by Luminex in very low-density lipoprotein (VLDL) isolated by ultracentrifugation, from HUMS samples. APOE genotyping was carried in AWHS and HUMS participants. Regression models adjusted for age and sex were used to study the association.ResultsThe 3 studies showed an inverse relationship between TG and Lp(a). Increased VLDL number, size, and TG content were associated with significantly lower Lp(a). There was an inverse association between the apoE concentration in VLDL and Lp(a). No significant association was observed for apolipoprotein (apo)B. Subjects carrying the apoE2/E2 genotype had significantly lower levels of Lp(a).ConclusionOur results show an inverse relationship Lp(a)-TG. Subjects with larger VLDL size have lower Lp(a), and lower values of Lp(a) were present in patients with apoE-rich VLDL and apoE2/E2 subjects. Our results suggest that bigger VLDLs and VLDLs enriched in apoE are inversely involved in Lp(a) plasma concentration.
Cathepsin K Mutation—A Subtle Clinical Presentation
Authors: Nandipati Venkata Sandeep , Chapla Aaron , Jebasingh Felix K , Charlu Arun Paul , Jepegnanam Thilak Samuel , Cherian Kripa Elizabeth , Paul Thomas V , Thomas Nihal 
Published: July 2022

Abstract

Context
Pyknodysostosis is an uncommon inherited disorder associated with consanguinity, often presenting with sclerotic bone disease, short stature, dysmorphic features, and recurrent fragility fractures at an early age.

Case
A 34-year-old woman was evaluated for the cause of recurrent fragility fractures. She was born of a third-degree consanguineous marriage and had a twin brother who was of short stature. The index patient had a height of 141 cm, dysmorphic features including frontoparietal bossing, blue sclera with short stubby fingers and toes. Radiological evaluation revealed diffuse osteosclerosis with acro-osteolysis exclusively in the toes, apart from mid-facial hypoplasia, lack of pneumatization of the paranasal sinuses, dental abnormalities, and scoliosis. Dual-energy x-ray absorptiometry revealed increased bone mineral density. Based on the clinical features, the patient was tested for cathepsin K gene variants using next-generation sequencing and was found to be positive for a novel homozygous c.224T&gt;C, p.Met75Thr likely pathogenic missense variant.

Discussion
This patient presented at a later age than expected with recurrent fragility fractures and the diagnosis was not suspected till adulthood, owing to the subtle clinical features. Confirmation with genetic testing helped in establishing the diagnosis.

Conclusion
Pyknodysostosis, although uncommon, is one of the differential diagnoses for diffuse osteosclerosis presenting with recurrent fragility fractures. Next-generation sequencing in an appropriate setting may confirm the diagnosis.
Examining the Gradient of All-Cause Mortality Risk in Women across the Cardiorespiratory Fitness Continuum
Authors: FARRELL STEPHEN W. , LEONARD DAVID , BARLOW CAROLYN E. , SHUVAL KEREM , PAVLOVIC ANDJELKA , DEFINA LAURA F. 
Published: July 2022

ABSTRACT

Purpose
Although cardiorespiratory fitness (CRF) is inversely associated with all-cause mortality in women, less is known regarding the gradient of mortality risk in women, particularly at the lower end of the CRF continuum.

Methods
A total of 17,901 healthy women (mean age, 45.9 yr) completed a baseline clinical examination, including a maximal treadmill exercise test at the Cooper Clinic in Dallas, TX, between 1971 and 2016. Participants were placed into CRF quintiles based on age and treadmill time.

Results
After a mean follow-up period of 17.9 yr, 1198 all-cause deaths occurred. More favorable cardiometabolic risk factors, smoking status, and physical activity levels were observed across ordered CRF quintiles (P < 0.001 for all). Adjusted all-cause mortality hazard ratios with 95% confidence intervals were 1.71 (1.40–2.09), 1.55 (1.29–1.87), 1.25 (1.03–1.51), 1.16 (0.97–1.38), and 1.0 (referent), respectively, across CRF quintiles (P trend ≤ 0.001). When utilizing CRF as a continuous variable in a spline analysis and using 4.5 METs as the referent, we estimate a 10% reduction in mortality risk per 1-MET increment in CRF (P < 0.001) until a threshold of approximately 11 METs. Mortality risk was approximately 50% lower at the 11-MET threshold when compared with the referent. No further significant reduction in mortality risk was observed beyond the 11-MET threshold. In addition, age-adjusted hemodynamic variables including resting and maximal double product, heart rate reserve, double-product reserve, and 1-min recovery heart rate were more favorable across CRF quintiles (P < 0.001 for all).

Conclusions
Beginning at a referent value of 4.5 METs, a significant decreasing gradient of all-cause mortality exists across the CRF continuum, until a threshold of approximately 11 METs is reached. Although all women should be encouraged to work toward meeting public health guidelines for physical activity, it is especially important to target those at the low end of the CRF continuum.
Module intervention to improve involvement and practices of fathers towards infant and young child feeding (IYCF) in Coastal South India - a randomized controlled trial
Authors: Mithra Prasanna , Unnikrishnan Bhaskaran , T Rekha , Kumar Nithin , Holla Ramesh , Rathi Priya 
Published: July 2022

Background: Overall child health depends on nutrition and its related practices. At the family level, responsibility of child feeding lies with both parents. There is no uniform and systematic way to determine and assess the practices of fathers in infant and young child feeding (IYCF). Also, there is a paucity of evidence related to interventions for fathers in improving their practices and involvement in the feeding of their infant or young child (aged less than two years). Methods: This was a community-based randomized control trial, conducted among 120 fathers with infants and/or young children in Dakshina Kannada District of Karnataka. Fathers with poor level of involvement and practices towards IYCF, during the initial assessment, were included as the study participants. For the intervention, a module in the flipchart format was developed. Simple randomization technique was used to allot the participants into two groups - intervention and control. Participants in the intervention group received module intervention, in addition to the care which they received routinely, and the control group received only routine care. The participants in the intervention group were paid a monthly visit to implement the module, for six months. The post-intervention assessment was done at the end of 6 months. Results: A total of 117 participants provided post-intervention data. The mean age was 34.7 (+/- 5.48) years in the intervention group and 34.36 years (+/- 5.26) in the control group. The intervention group showed significantly higher improvement in knowledge, attitude, and practice components at 6 months (p<0.05), in both unadjusted and adjusted models. Conclusions: The extent of increase in practice and involvement in child feeding was clearly higher among the intervention group. The module developed was successful in improving the practices of fathers in feeding their infants and young children. Clinical Trials Registry India: CTRI/2017/06/008936 (29/06/2017)
Better pandemic preparedness does correlate with lower COVID-19 mortality
Authors: Dowell Scott F , Wang Haidong , Blazes David 
Published: July 2022

Paradoxically, many countries with strong pandemic preparedness have reported high coronavirus disease 2019 (COVID-19) mortality. After adjusting for country under-reporting by using total excess mortality estimates, and age distributions by using indirect standardization, we find the resulting comparative mortality ratios are predicted by pandemic preparedness. Countries with higher scores on the Global Health Security Index had significantly lower COVID-19 mortality (r(192) = -.32, p<.001). These findings can help inform and prioritize future pandemic preparedness work.
Evaluation of a multicomponent intervention to shorten thrombolytic door-to-needle time in stroke patients in China (MISSION): A cluster-randomized controlled trial
Authors: Zhong Wansi , Lin Longting , Gong Xiaoxian , Chen Zhicai , Chen Yi , Yan Shenqiang , Zhou Ying , Zhang Xuting , Hu Haitao , Tong Lusha , Cheng Chaochan , Gu Qun , Chen Yong , Yu Xiaojin , Huang Yuhui , Yuan Changzheng , Lou Min ,   for the MISSION investigators
Published: July 2022

Background
Rapid intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) is crucial for improving outcomes. However, few randomized trials of interventions aimed at reducing in-hospital delay have been carried out in China. We aimed to evaluate the effect of a multicomponent intervention on thrombolytic door-to-needle time (DNT) of AIS patients via video teleconference based on the Behavior Change Wheel (BCW) method.

Methods and findings
This cluster-randomized trial, conducted between January 1, 2019 and December 31, 2019, randomly allocated 22 hospitals equally to PEITEM (Persuasion Environment reconstruction Incentivization Training Education Modeling) intervention or routine care plus stroke registry and subsequently enrolled 1,634 AIS patients receiving IVT within 4.5 hours upon stroke onset from participant hospitals. The PEITEM group received a 1-year PEITEM 6-component intervention based on the behavioral theory monthly via video teleconference. The primary outcome was the proportion of patients with a DNT of 60 minutes or less. A total of 987 patients participated in the PEITEM group (mean age, 69 years; female, 411 [41.6%]) and 647 patients in the control group (mean age, 70 years; female, 238 [36.8%]). Of all participants, the proportion of DNT ≤60 minutes in the PEITEM group was higher than in the control group (82.0% versus 73.3%; adjusted odds ratio, 1.77; 95% confidence interval (CI), 1.17 to 2.70; ICC, 0.04; P = 0.007). Among secondary outcomes, the average DNT was 43 minutes in the PEITEM group and 50 minutes in the control group (adjusted mean difference: −8.83; 95% CI, −14.03 to −3.64; ICC, 0.12; P = 0.001). Favorable functional outcome (score of 0 to 1 on the modified Rankin scale (mRS)) was achieved in 55.6% patients of the PEITEM group and 50.4% of the control group (adjusted odds ratio, 1.38; 95% CI, 1.00 to 1.90; ICC, 0.01; P = 0.049). Main study limitations include non-blinding of clinicians, and that specific interventions component responsible for the observed changes could not be determined.

Conclusions
The teleconference-delivered PEITEM intervention resulted in a moderate but clinically relevant shorter DNT and better functional outcome in AIS patients receiving IVT.

Trial registration
Clinicaltrials.gov NCT03317639.
Urbanes Laboratorium Dokk1 in Århus – Kultur- und Demokratieförderung als Standortfaktoren
Authors: Wischmann Antje 
Published: July 2022

Zusammenfassung
Dieser Beitrag untersucht die multifunktionale Bibliothek Dokk1, die international als exemplarische Stadtbibliothek der Zukunft Bekanntheit erlangt hat. Der erste Teil des Artikels widmet sich einer Beschreibung der raumzeitlichen Konstellationen und sozialen Interaktionen innerhalb und außerhalb des imposanten Gebäudes an der Hafenspitze von Århus. Die in der Beschreibung angewandte raumsoziologische Perspektive wird im zweiten Teil auf die Maßnahmen und Zielsetzungen im Sinne der Demokratieförderung übertragen, wie sie u. a. in den kommunalen Leitdokumenten formuliert worden sind. Da die Orientierung an den Nutzer:innen als wichtigster Grundsatz des Bibliothekspersonals gilt, wird in diesem Beitrag das Verhalten der Besuchenden sowie der Mitarbeitenden als stellvertretend für ein alltägliches demokratisches Aushandeln aufgefasst. Abschließend wird der Frage nachgegangen, inwiefern das soziale Miteinander in der Bibliothek und die lokale Demokratie in Århus kommun aufeinander bezogen sein könnten.
Principal component and cluster analyses based characterization of maize fields in southern central Rift Valley of Ethiopia
Authors: Markos Daniel , Mammo Girma , Worku Walelign 
Published: July 2022

Abstract
Soil management decisions should consider physical potential of the environment, weather variability, and requirements of crops to maximize production to the potential limits. This calls for characterization of environments using selected input variables. Such studies are scanty in southern central Rift Valley of Ethiopia due to which the area is considered homogeneous and identical for agricultural planning, extension, and input delivery programs. Thus, to investigate the scenario, we employed principal component, clustering, and GIS analysis on geo-referenced physiographic and climatic attributes, and their statistical variables obtained from 43 stations with the objective of identifying homogeneous management units with similar physiography, weather pattern, and production scheduling. The analysis of principal components (PCs) indicated that three PCs explained 74.7% of variance in October, November, December, and January (ONDJ), four PCs explained 79.3% of variance in February, March, April, and May, and four PCs explained 80.5% of variance in June, July, August, and September (JJAS). Cluster-I was characterized by high altitude and low temperature in ONDJ season. Cluster-II was characterized by low altitude and high temperature across most seasons. Cluster-III was intermediate in altitude, temperature, and rainfall. Cluster-IV was characterized by high rainfall in JJAS. In all the clusters, PC1 was the mean rainfall component with strong association with altitude and longitude, while PC2 was the temperature component. PC3 is the statistical component with strong influence from mean rainfall. Thus the factors that determine the formation of clusters are reduced from 12 to 5 (T
mean, latitude, longitude, altitude, and RFmean) and 43 stations are grouped into 4 clusters (Shamana, Bilate, Hawassa, and Dilla) which are geographically and ecologically distinct. These clusters require different sets of agro-meteorology advisory, maize management, and input delivery strategies.
Effect of LDH on the dissolution and adsorption behaviors of sulfate in Portland cement early hydration process
Authors: Qiu Zedong , Deng Limin , Lu Shuang , Li Guoqiang , Tang Zhen 
Published: July 2022

Abstract
In recent years, it has been widely recognized that the incorporation of Mg–Al–LDH into cement-based materials can improve the salt corrosion resistance of cement-based materials. The reason for the improvement comes from the anion adsorption capacity of Mg–Al–LDH. It was confirmed that the addition of Mg–Al–LDH would accelerate the setting and hardening of cement paste. With the increase in the Mg–Al-LDH content, the initial setting time of cement slurry with different gypsum contents will decrease by 10–50% and the viscosity of the cement slurry will increase by 100–200%. Depending on different gypsum contents, the degree of cement hydration varied. This article also found that the gypsum in the cement has a negative effect on the resistance to salt erosion, which was brought about by the Mg–Al-LDH adsorption capacity.
Prediction Model for Croup Admission Need
Authors: Maalouli Walid , Petersen Ashley , Strutt Jonathan , Bergmann Kelly R. , Axelrod Alyssa , Lee Grace , Hester Gabrielle Z. 
Published: July 2022

OBJECTIVES
This study aims to generate a predictive model stratifying the probability of requiring hospitalization and inpatient respiratory intervention for croup patients presenting to the emergency department (ED), and secondarily to compare the model’s performance with that of ED providers.

METHODS
Retrospective data was collected on croup patients presenting to the EDs of 2 pediatric and 1 community hospital from 2019 to 2020, including demographics, preexisting conditions, and history of croup. The ED length of stay, previous dexamethasone administration, time to ED dexamethasone, number of ED racemic epinephrine doses, viral testing, and ED revisits were also recorded. Westley croup scores were derived at ED presentation and final disposition. For admitted patients, any respiratory interventions were recorded. Admission need was defined as either admitted and required an inpatient intervention or not admitted with ED revisit. A prediction model for admission need was fit using L1-penalized logistic regression.

RESULTS
We included 2951 patients in the study, 68 (2.3%) of which needed admission. The model’s predictors were disposition Westley croup scores, number of ED racemic epinephrine doses, previous dexamethasone administration, and history of intubation. The model’s sensitivity was 66%, specificity was 91%, positive predictive value was 15%, and negative predictive value was 99%. ED providers’ performance had a sensitivity of 72%, a specificity of 94%, a positive predictive value of 23%, and a negative predictive value of 99%.

CONCLUSIONS
The croup admission need predictive model appears to support clinical decision making in the ED, with the potential to improve decision making when pediatric expertise is limited.
36 investigaciones en arquitectura. 2005-2021
Authors: Medina Roberto Carlos 
Published: July 2022

Forman parte de esta sección los Proyectos de Investigación realizados entre 2005 y 2021.
Los mismos se dividen en 3 etapas, coincidentes con la creación y desarrollo de los Centros de Investigación de la Facultad de Arquitectura (el Centro de Estudios y Desarrollo de Tecnologías y Producción, el Centro Avanzado de Investigación y el Centro de Investigaciones en Arquitectura). La etapa A comprende las investigaciones producidas entre el 2005 y el 2011, en donde se realizaron 12 investigaciones; la etapa B es integrada por los trabajos producidos entre 2012 y 2014, en total son 9 investigaciones; por último, en la etapa C se exponen los proyectos realizados a partir del año 2015 hasta 2021. Cada Proyecto se inicia con un resumen, el mismo contiene el tema abordado, los resultados obtenidos, la vinculación lograda con las cátedras en las cuales los investigadores desempeñaron su labor docente y el detalle de los investigadores formados.