bluuebunny/crossref_metadata_2025_split huggingface dataset:
La Divina Comedia en el arte
Authors: Ramírez Morales Ana Cristina 
Published: August 2022

Desde su publicación, La Divina Comedia del afamado poeta florentino Dante Alighieri causó revoluciones en la cultura y en el arte. Sus concepciones acerca de cuestiones metafísicas y sumamente trascendentes en su época, con restos del pensamiento medieval, como el cielo, el infierno y el purgatorio han tenido un impacto indiscutible en los ámbitos de la vida social de siglos posteriores al suyo, incluyendo al nuestro, donde podemos observar su presencia en música, películas y hasta videojuegos. Es por tal razón que pensar en la influencia artística de esta magna obra no es una tarea fuera de lugar, especialmente si se busca su huella en las obras gráficas de la pintura y el grabado, tomando en cuenta el contexto del autor y su biografía para situar su producción en su tiempo.
La Escuela Normal de Profesoras en Aguascalientes: 1910-1934. Una perspectiva de género
Authors: Ramos de León Maricela 
Published: August 2022

El presente artículo describe los proyectos educativos de carácter político que reflejaban una educación patriarcal, pero que poco a poco tuvieron una transformación en la que comenzaron a incursionar las mujeres. Se menciona la historia de la Normal de Aguascalientes y su contexto, el cual es de gran importancia, sobre todo durante la Revolución mexicana, en la cual las mujeres reproducían modelos culturales educativos que tenían como objetivo el fortalecimiento de un discurso androcéntrico, patriarcal y de subordinación de las mujeres.
Las reformas educativas de entre 1920 y 1940 pretendieron llevar la educación a toda la población y vincular la nueva escuela con las reformas sociales y económicas gubernamentales.
La formación de la clase trabajadora en Aguascalientes. Un acercamiento teórico
Authors: Gutiérrez Díaz Mario 
Published: August 2022

Esta investigación describe el surgimiento del proletariado en Aguascalientes, el cual se remonta a la época del porfiriato y los primeros años de la revolución. Dicho grupo social se originó a causa de las condiciones infrahumanas y de subordinación aplicadas por el neoliberalismo. En Aguascalientes la clase trabajadora se formó con campesinos y artesanos, los cuales comenzaron a ser explotados por la clase dominante respecto a: lugares de trabajo, salarios, tiendas de raya, condiciones laborales, alimentación, etcétera.
Tiempo después la clase obrera dejó de ser servidora de la clase capitalista para volverse opositora, con lo cual sufrió la represión del Estado.
To pre-history of the term «economy»
Authors: Selishchev Nikolay 
Published: August 2022

In the paper it is analyzed pre-history of the term «economy» – from antiquity to contemporaneity. It is noted how in 2022 year changes of the term «economy» are happened, shortcomings of narrow-market perception of «economy», to that academician V. L. Makarov pays attention truly. It is studied diversity of types of economies, the possibility of restoration of Ruble’s gold standard in Russia, the role of Rome-Byzantine and medieval Catholic canon law in gradual development of economic terminology.
Impacto en la morbilidad de la técnica quirúrgica abierta vs cerrada en cáncer de colon
Authors: Vivanco Armijos Hugo Bladimir , Guallasamín Chalco Edwin Fabián , Yépez Maldonado José 
Published: August 2022

Introducción: La cirugía laparoscópica es una alternativa segura para el tratamiento en el cáncer de colon y además permite todas las ventajas de un procedimiento de mínima invasión. El objetivo de la presente investigación fue medir el impacto en la morbilidad de la técnica quirúrgica abierta vs cerrada en cáncer de colon.
Metodología: El estudio se realizó en el Hospital Solón Espinosa Ayala, en Quito-Ecuador, período marzo del 2012 hasta marzo del 2017, con una muestra no probabilística, se incluyeron pacientes mayores de edad, con cáncer de colon. Se incluyen variables socio-demográficas, histología, días de hospitalización, sangrado quirúrgico, tiempo quirúrgico, estancia hospitalaria, márgenes quirúrgicos, ganglios resecados, inicio de dieta, % de conversión quirúrgica, complicación quirúrgica, recidiva, morbilidad quirúrgica, mortalidad quirúrgica. Se utiliza estadística descriptiva univariada y bivariada.
Resultados: Se analizan 85 casos, 52 casos se realizaron cirugía abierta y 33 casos se realizaron cirugía laparoscópica. La conversión quirúrgica fue 75% por adherencias y 25% por infiltración a duodeno. El tiempo quirúrgico similar 121 a 180 minutos 61%. Complicaciones laparoscópicas 2,3% y 9,4% abierta (colecciones pélvicas y fistulas intestinales 2.4% vs 1.7%). La desnutrición no presentó relación. Inicio de dieta 2 a 4 días 83% laparoscópica y 67% abierta. Hospitalización de 4 a 8 días fue laparoscópica 87% y abierta 78%. Pérdida sanguínea menor a 100cc fue laparoscópicas 82%, y abiertas 60%. La resección de ganglios (+13) en laparoscopía 69.6% y abierta 68.1%. El margen proximal de pieza quirúrgica por laparoscopía 5.1 a 10 cm (43.5%), por abierta (55.3%), la recaída tumoral del 56.2% y 52.3%. El estado vital por laparoscopía fue fallecido 12.5%, y abierta 28.8%, en relación a su enfermedad tumoral
Conclusión: Las comorbilidades quirúrgicas y recuperación fueron menores por laparoscopía, pero la cirugía abierta mostro mejores resultados anatomopatológicos post quirúrgicos.
Crowdsourcing Relative Rankings of Multi-Word Expressions: Experts versus Non-Experts
Authors: Alfter David , Lindström Tiedemann Therese , Volodina Elena 
Published: August 2022

In this study we investigate to which degree experts and non-experts agree on questions of linguistic complexity in a crowdsourcing experiment. We ask non-experts (second language learners of Swedish) and two groups of experts (teachers of Swedish as a second/foreign language and CEFR experts) to rank multi-word expressions in a crowdsourcing experiment. We nd that the resulting rankings by all the three tested groups correlate to a very high degree, which suggests that judgments produced in a comparative setting are not inuenced by professional insights into Swedish as a second language.
Bacteria from gut microbiota associated with diarrheal infections in children promote virulence of Shiga toxin-producing and enteroaggregative Escherichia coli pathotypes
Authors: Izquierdo Mariana , Lopez Joaquín , Gallardo Pablo , Vidal Roberto M. , Ossa Juan C. , Farfan Mauricio J. 
Published: August 2022

BackgroundDiarrheagenic E. coli (DEC) pathogenicity relies on the interaction of bacteria with the host’s gut environment, which is regulated by the resident microbiota. Previously, we identified indicative bacterial species of gut microbiota in DEC-positive stool samples from children. Here, we evaluated the role of two indicative species, Citrobacter werkmanii (CW) and Escherichia albertii (EA), in the virulence of two DEC pathotypes, Shiga toxin-producing (STEC) and enteroaggregative (EAEC) Escherichia coli.MethodsWe determined the effect of supernatants obtained from CW and EA cultures on the gene expression of STEC strain 86-24 and EAEC strain 042 by RNA-seq analysis. We evaluated IL-8 secretion from T84 cells infected with these DEC strains in the presence or absence of the supernatant from EA. The effect of the supernatant from EA on the growth and adherence of STEC and EAEC to cells was also evaluated. Finally, we studied the effect of the EA supernatant on the STEC-induced inflammation mediated by the long polar fimbriae (Lpf) in T84 cells and the expression of plasmid-encoded toxin (Pet) in EAEC.ResultsRNA-seq analysis revealed that several virulence factors in STEC and EAEC were upregulated in the presence of supernatants from CW and EA. Interestingly, an increase in the secretion of IL-8 was observed in cells infected with STEC or EAEC in the presence of a supernatant from EA. Similar results were observed with the supernatants obtained from clinical strains of E. albertii. The supernatant from EA had no effect on the growth of STEC and EAEC, or on the ability of these DEC strains to adhere to cells. We found that Pet toxin in EAEC was upregulated in the presence of a supernatant from EA. In STEC, using mutant strains for Lpf fimbriae, our data suggested that these fimbriae might be participating in the increase in IL-8 induced by STEC in cells in the presence of a supernatant from EA.ConclusionSupernatant obtained from an indicative species of DEC-positive diarrhea could modulate gene expression in STEC and EAEC, and IL-8 secretion induced by these bacteria. These data provide new insights into the effect of gut microbiota species in the pathogenicity of STEC and EAEC.
Outcomes of postoperative delirium in patients undergoing cardiac surgery: A systematic review and meta-analysis
Authors: Lin Lingyu , Zhang Xuecui , Xu Shurong , Peng Yanchun , Li Sailan , Huang Xizhen , Chen Liangwan , Lin Yanjuan 
Published: August 2022

BackgroundPostoperative delirium (POD) is an acute brain dysfunction that is frequently observed in patients undergoing cardiac surgery. Increasing evidence indicates POD is related to higher mortality among cardiac surgical patients, but the results remain controversial. Moreover, a quantitative evaluation of the influence of POD on hospital days, intensive care unit (ICU) time, and mechanical ventilation (MV) time has not been performed.ObjectiveThis study aimed to evaluate the correlation between POD and outcomes in patients undergoing cardiac surgery by a systematic review and meta-analysis.Materials and methodsA total of 7 electronic databases (Cochrane Library, PubMed, EMBASE, CINAHL Complete, MEDLINE, Wan-fang database, and China National Knowledge Infrastructure) were searched from January 1980 to July 20, 2021, with language restrictions to English and Chinese, to estimate the impact of the POD on outcome in patients who underwent cardiac surgery. The meta-analysis was registered with PROSPERO (Registration: CRD42021228767).ResultsForty-two eligible studies with 19785 patients were identified. 3368 (17.0%) patients were in the delirium group and 16417 (83%) were in the non-delirium group. The meta-analysis showed that compared to patients without POD, patients with POD had 2.77-fold higher mortality (OR = 2.77, 95% CI 1.86–4.11, P &lt; 0.001), 5.70-fold higher MV (&gt;24h) rate (OR = 5.70, 95% CI 2.93–11.09, P &lt; 0.001); and longer MV time (SMD = 0.83, 95% CI 0.57–1.09, P &lt; 0.001), ICU time (SMD = 0.91, 95% CI 0.60–1.22, P &lt; 0.001), hospital days (SMD = 0.62, 95% CI 0.48–0.76, P &lt; 0.001).ConclusionThe synthesized evidence suggests that POD is causally related to the increased risk of mortality, prolonged length of ICU and hospital stay, and a longer duration of MV time. Future research should focus on the interventions for POD, to reduce the incidence.Systematic review registration[www.crd.york.ac.uk/PROSPERO], identifier [CRD42021228767].
Serial assessment of early antibody binding to decellularized valved allografts
Authors: Oripov Firdavs , Ramm Robert , Falk Christine , Goecke Tobias , Ebken Johannes , Jashari Ramadan , Böthig Dietmar , Horke Alexander , Avsar Murat , Bobylev Dmitry , Haverich Axel , Hilfiker Andres , Sarikouch Samir 
Published: August 2022

ObjectivesDecellularized homograft valves (DHV) appear to elicit an immune response despite efficient donor cell removal.Materials and methodsA semiquantitative Dot-Blot analysis for preformed and new recipient antibodies was carried out in 20 patients following DHV implantation on days 0, 1, 7, and 28 using secondary antihuman antibodies. Immune reactions were tested against the implanted DHV as well as against the stored samples of 5 non-implanted decellularized aortic (DAH) and 6 pulmonary homografts (DPH).ResultsIn this study, 20 patients (3 female and 17 male patients) were prospectively included, with a median age of 18 years and an IQR of 12–30 years. Six patients received DPH and 14 received DAH. The amount of antibody binding, averaged for all patients, decreased on post-operative days 1 and 7 compared to pre-operative values; and on day 28, antibody binding reached close to pre-operative levels (16.8 ± 2.5 on day 0, 3.7 ± 1.9 on day 1, 2.3 ± 2.7 on day 7, and 13.2 ± 3.7 on day 28). In comparison with the results in healthy controls, there was a higher amount of antibody binding to DAH than to DPH. The mean number of arbitrary units was 18.4 ± 3.1 in aortic and 12.9 ± 4.5 in pulmonary DHV (p = 0.140). Male patients exhibited higher antibody binding to aortic DHV than female patients (19.5 ± 2.1 vs. 1.6 ± 6.7). The p-value calculation was limited, as only two female patients received DAH. There was no correlation between the amount of overall antibody binding to DHV with respect to donor age (Kruskal–Wallis test p = 0.550). DHV recipients with a sex mismatch to the donor showed significantly less antibody binding (6.5 ± 1.8 vs. 13.7 ± 1.8; p = 0.003). Our main finding was an increase in antibody binding in younger patients receiving decellularized aortic allografts. This increase was higher in patients with early degeneration signs but was not specific to the individual DHV implanted nor previous DHV implantation. Antibody binding toward explanted DHV was significantly increased in implicating antibody-mediated DHV degeneration.ConclusionSerial assessment of tissue-specific antibody binding revealed an increase in some patients within 4 weeks after surgery, who subsequently developed early signs of allograft degeneration. Further studies with larger sample sizes are needed to confirm the prognostic relevance of increased antibody activity in addition to targeted research efforts to identify the molecular agents triggering this type of antibody response.
β-sheets in serum protein are independent risk factors for coronary lesions besides LDL-C in coronary heart disease patients
Authors: Li Yu-lin , Xie Jia-ying , Lu Bin , Sun Xiao-di , Chen Fang-fang , Tong Zhou-jie , Sai Wen-wen , Zhang Wei , Wang Zhi-hao , Zhong Ming 
Published: August 2022

BackgroundCoronary heart disease (CHD) patients with standard low-density lipoprotein cholesterol (LDL-C) remain at risk of cardiovascular events, making it critical to explore new targets to reduce the residual risk. The relationship between β-sheet conformation and CHD is gaining attention. This study was designed to compare the coronary lesions in CHD patients with varying LDL-C and evaluate whether serum β-sheets are associated with coronary damage.MethodsTwo hundred and one patients diagnosed with stable CHD were recruited and divided into four groups according to LDL-C. Baseline information, coronary lesion-related indicators, and peripheral blood samples were collected. Serum β-sheet content was determined by thioflavin T fluorescence.ResultsThe baseline information was comparable in CHD patients with different LDL-C. No difference was found in indicators relevant to coronary lesions among groups. The content of β-sheet was negatively correlated with LDL-C. Multiple linear regression revealed that serum β-sheet was positively correlated with coronary lesion when risk factors such as age, smoking, and LDL-C were controlled.ConclusionsThis is the first study that reports the serum β-sheet levels of CHD patients being gradually increased with decreasing LDL-C when coronary lesions were comparable. Serum β-sheet might exacerbate the coronary lesions in CHD patients independent of known risk factors such as LDL-C.
Incremental value of preoperative right ventricular function in predicting moderate to severe acute kidney injury after heart transplantation
Authors: Zhu Shuangshuang , Zhang Yanting , Qiao Weihua , Wang Yixuan , Xie Yuji , Zhang Xin , Wu Chun , Wang Guohua , Li Yuman , Dong Nianguo , Xie Mingxing , Zhang Li 
Published: August 2022

BackgroundAcute kidney injury (AKI) commonly occurs after heart transplantation (HTx), but its association with preoperative right ventricular (RV) function remains unknown. Consequently, we aimed to determine the predictive value of preoperative RV function for moderate to severe AKI after HTx.Materials and methodsFrom 1 January 2016 to 31 December 2019, all the consecutive HTx recipients in our center were enrolled and analyzed for the occurrence of postoperative AKI staged by the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Conventional RV function parameters, including RV fractional area change (RVFAC) and tricuspid annular plane systolic excursion (TAPSE), were obtained. The primary endpoint was moderate to severe AKI (the KDIGO stage 2 or 3). The secondary endpoints included the impact of AKI on intensive care unit (ICU) mortality, in-hospital mortality, and 1-year mortality.ResultsA total of 273 HTx recipients were included in the study. Postoperative AKI occurred in 209 (77%) patients, including 122 (45%) patients in stage 1 AKI, 49 (18%) patients in stage 2 AKI, and 38 (14%) patients in stage 3 AKI. Patients with higher AKI stage had lower baseline estimated glomerular filtration rate (eGFR), more frequent diabetes, higher right atrial pressure (RAP), longer cardiopulmonary bypass (CPB) duration, more perioperative red blood cell (RBC) transfusions, and worse preoperative RV function. A multivariate logistic regression model incorporating previous diabetes mellitus [odds ratio (OR): 2.21; 95% CI: 1.06–4.61; P = 0.035], baseline eGFR (OR: 0.99; 95% CI: 0.97–0.10; P = 0.037), RAP (OR: 1.05; 95% CI: 1.00–1.10; P = 0.041), perioperative RBC (OR: 1.18; 95% CI: 1.08–1.28; P &lt; 0.001), and TAPSE (OR: 0.84; 95% CI: 0.79–0.91; P &lt; 0.001) was established to diagnose moderate to severe AKI more accurately [the area under the curve (AUC) = 79.8%; Akaike information criterion: 274].ConclusionPreoperative RV function parameters provide additional predicting value over clinical and hemodynamic parameters, which are imperative for risk stratification in patients with HTx at higher risk of AKI.
Do fluoroquinolones increase aortic aneurysm or dissection incidence and mortality? A systematic review and meta-analysis
Authors: Chen Can , Patterson Benjamin , Simpson Ruan , Li Yanli , Chen Zhangzhang , Lv Qianzhou , Guo Daqiao , Li Xiaoyu , Fu Weiguo , Guo Baolei 
Published: August 2022

ObjectiveThe aim of this study was to determine the association between fluoroquinolones (FQs) use, the risk of de novo aortic aneurysm or dissection (AAD), and the prognosis of patients with pre-existing AAD.Materials and methodsWe searched PubMed, EMBASE, CENTRAL, Scopus, and Web of Science on 31 March 2022. Observational studies that evaluated the association of FQs with AAD risk in the general population or FQs with the prognosis of patients with preexisting AAD and presented adjusted effect estimates were included. Two reviewers assessed study eligibility, extracted data, and assessed the risk of bias and certainty of evidence using GRADE.ResultsOf the 13 included studies, 11 focused on the association of FQs with de novo AAD incidence, and only one study investigated the association of FQs with the patient with AAD prognosis. FQ use was associated with an increased risk of de novo AAD within 30 days (RR: 1.42; 95% CI: 1.11–1.81; very low certainty) and 60 days (RR: 1.44; 95% CI: 1.26–1.64; low certainty). Specifically, the association was significant when compared with amoxicillin, azithromycin, doxycycline, or no antibiotic use. Furthermore, patients with preexisting AAD exposure to FQ had an increased risk of all-cause mortality (RR: 1.61; 95% CI: 1.50–1.73; moderate certainty) and aortic-specific mortality (RR: 1.80; 95% CI: 1.50–2.15; moderate certainty), compared to the non-exposed FQ group within a 60-day risk period.ConclusionFQs were associated with an increased incidence of AAD in the general population and a higher risk of adverse outcomes in patients with preexisting AAD. Nevertheless, the results may be affected by unmeasured confounding factors. This should be considered by physicians contemplating using FQs in patients with aortic dilation and those at high risk of AAD.Systematic Review Registration[https://www.crd.york.ac.uk/prospero/], identifier [CRD42021230171].
First-in-human pilot trial of combined intracoronary and intravenous mesenchymal stem cell therapy in acute myocardial infarction
Authors: Hsiao Lien-Cheng , Lin Yen-Nien , Shyu Woei-Cherng , Ho Ming , Lu Chiung-Ray , Chang Shih-Sheng , Wang Yu-Chen , Chen Jan-Yow , Lu Shang-Yeh , Wu Mei-Yao , Li Keng-Yuan , Lin Yu-Kai , Tseng Wen-Yih I. , Su Mao-Yuan , Hsu Chin-Ting , Tsai Cheng-Kang , Chiu Lu-Ting , Chen Chien-Lin , Lin Cheng-Li , Hu Kai-Chieh , Cho Der-Yang , Tsai Chang-Hai , Chang Kuan-Cheng , Jeng Long-Bin 
Published: August 2022

BackgroundAcute ST-elevation myocardial infarction (STEMI) elicits a robust cardiomyocyte death and inflammatory responses despite timely revascularization.ObjectivesThis phase 1, open-label, single-arm, first-in-human study aimed to assess the safety and efficacy of combined intracoronary (IC) and intravenous (IV) transplantation of umbilical cord-derived mesenchymal stem cells (UMSC01) for heart repair in STEMI patients with impaired left ventricular ejection fraction (LVEF 30-49%) following successful reperfusion by percutaneous coronary intervention.MethodsConsenting patients received the first dose of UMSC01 through IC injection 4-5 days after STEMI followed by the second dose of UMSC01 via IV infusion 2 days later. The primary endpoint was occurrence of any treatment-related adverse events and the secondary endpoint was changes of serum biomarkers and heart function by cardiac magnetic resonance imaging during a 12-month follow-up period.ResultsEight patients gave informed consents, of whom six completed the study. None of the subjects experienced treatment-related serious adverse events or major adverse cardiovascular events during IC or IV infusion of UMSC01 and during the follow-up period. The NT-proBNP level decreased (1362 ± 1801 vs. 109 ± 115 pg/mL, p = 0.0313), the LVEF increased (52.67 ± 12.75% vs. 62.47 ± 17.35%, p = 0.0246), and the wall motion score decreased (26.33 ± 5.57 vs. 22.33 ± 5.85, p = 0.0180) at the 12-month follow-up compared to the baseline values. The serial changes of LVEF were 0.67 ± 3.98, 8.09 ± 6.18, 9.04 ± 10.91, and 9.80 ± 7.56 at 1, 3, 6, and 12 months, respectively as compared to the baseline.ConclusionThis pilot study shows that combined IC and IV transplantation of UMSC01 in STEMI patients with impaired LVEF appears to be safe, feasible, and potentially beneficial in improving heart function. Further phase 2 studies are required to explore the effectiveness of dual-route transplantation of UMSC01 in STEMI patients.