bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated of HSP90 associates with expression of EGFR levels and predicts poor prognosis in non-small cell lung cancer patients
Authors: Zhou Ying , Tang Yaoxiang , Luo Jiadi , Yang Yang , Zang Hongjing , Ning Yue , Zheng Hongmei , Fan Songqing , Wen Qiuyuan 
Published: October 2022

Abstract
Background
The molecular chaperone protein HSP90 is a crucial mediator of proteostasis in eukaryotic cells under various stress conditions. EGFR participates in signal transduction relating to tumorigenesis and progression. The relationship between the combined expression of HSP90 and EGFR in non-small cell lung cancer (NSCLC) and clinicopathological features and long-term prognosis is not clear.
Methods
We analyzed The Cancer Genome Atlas (TCGA) gene data from Xiantao platform and GEPIA2 to study the expression of HSP90 and EGFR on mRNA level and their correlation in patients with NSCLC. Besides, 53 normal lung samples and 352 paraffin-embedded NSCLC were selected randomly for immunohistochemical (IHC) staining with anti-HSP90 and anti-EGFR antibodies, respectively.
Results
The TCGA data revealed that HSP90 and EGFR expression on mRNA and protein was significantly higher in NSCLC patients than non-cancerous lung tissues (Non-CLT) (both p < 0.05). Moreover, increased HSP90 showed a positively correlation with EGFR in mRNA levels (both p < 0.0001). Higher HSP90 expression appeared in lymph node metastasis (LNM) or advanced clinical stage of NSCLC (p = 0.019, p = 0.013, respectively). The survival rate of high expression of HSP90 and EGFR alone or in combination was lower than that of other phenotypes in NSCLC (p < 0.001, P = 0.011, p < 0.001, respectively). In multivariate Cox proportional hazard regression analysis, HSP90 and EGFR were further identified as independent poor prognostic factors in NSCLC.
Conclusions
Elevated HSP90 and EGFR might suggest a synergistical role in promoting the development in patients with NSCLC. High expression of these two proteins might be novel prognostic biomarker for NSCLC, who provides potential application value for NSCLC targeted therapy.
Population Divergence in the Mate Choice of Tribolium castaneum and Its Association with Gut Bacteria
Authors: Wang Zhengyan , Wang Yang , Lu Yujie 
Published: October 2022

Abstract
To reveal population divergence in the mate choice and its mechanistic basis, the mating rhythm, mating preference and male volatile profiles of Tribolium castaneum were studied. During ten days after emergence, six geographical populations of T. castaneum exhibited an identical daily or diurnal mating rhythm. Males showed significant attraction to females while females did not show attraction to males. Furthermore, male attraction to females varied significantly within six populations, while female preference to males did not. Males from the HBWH population were most attractive to females sequentially followed by males from the populations of SHJD, HNZZ, GA1, GDST, and ZJJX, which was positively correlated with their 4,8-dimethyldecanal (DMD) production. Gnotobiotic reinoculation of two gut bacteria, Citrobacter freundii and Escherichia coli, to axenic males significantly enhanced their attraction to females and DMD production. It could be concluded that: (i) in the mate choice of T. castaneum, males were more like the sexual pheromone senders and females were the pheromone receivers; (ii) there was detectable divergence in the chemical communication among six populations of T. castaneum, which could be attributed to alterations in the male pheromone production rather than changes in the female pheromone perception; and (iii) gut bacteria could modulate the chemical communication of the host by interfering with the pheromone production. Such knowledge will provide insights into optimizing trapping technologies for pest management.
Land use/land cover changes and its drivers in Shekayboru area of Chifra District in Afar Region, Ethiopia
Authors: Fetene Truset , Dessie Nahusenay Abate , Amede Tilahun 
Published: October 2022

Abstract
For long-term land management, understanding the scope, direction, and agents of LULC change, as well as their configuration across geographical and temporal dimensions, is essential. This study looked at the patterns and extents of LULC change in Chifra District's Shekayboru Area for that aim. Landsat imagery from TM and ETM+ (2009/10) and OLI were used to investigate the dynamics of LULCC (2015 and 2020). A hybrid method was used to categorize the LULC maps for each period using the results of supervised classification and intense on-screen-digitizing approaches. Three major LULC types (vegetation, cultivation, and bare lands) were identified, with overall accuracies ranging from 91.3 to 100%. According to the 2009/10 LULC classification map, bare lands had the highest area coverage (around 87%), while in 2015 and 2020, both vegetation and cultivated lands showed increment trends of 26 and 28 percent (2015), and 29 and 44 percent (2020), respectively, and bare lands showed decrement trends of 46 and 28 percent, respectively. The study area's Focus Group Discussions and interviews further revealed that, as a result of the water spreading weir, vegetation and cultivated fields have increased over time, and local villagers have taken up maize farming. Better soil and water conservation methods may be responsible for the increase in plant cover. The outcomes of this study will help design future soil and water conservation measures in response to sustainable land management. According to the researcher, a study of soil fertility, quality, and moisture content should be conducted in the future.
Scaling up an intervention to protect preterm infants from neurodevelopmental disabilities – findings from a qualitative process evaluation comparing standard with enhanced Quality Improvement support packages for maternity units in England
Authors: Redwood Sabi , Pithara-McKeown Christalla , Stone Tracey , Treloar Emma , Donovan Jenny L , Luyt Karen 
Published: October 2022

Abstract
Background
A Quality Improvement strategy (PReCePT) was used in a standard and intensive format to scale up a clinical intervention (administering magnesium sulphate to women in preterm labour) across all maternity units in England to protect prematurely born infants from neurodevelopmental disabilities. Formal evaluations reported the effectiveness of the standard package alone in increasing the administration of magnesium sulphate. In this paper, we focus on the findings of the process evaluations, using Normalisation Process Theory to explain how different implementation contexts generated the observed outcomes relating to normative and relational restructuring, and sustainment.
Methods
Interviews were conducted with key individuals in implementation leadership positions nationally and locally. Interviews were analysed initially using the framework method. We then engaged recursively with NPT constructs to generate generalisable insights with pragmatic applicability in other scenarios.
Results
In total, 72 interviews were conducted with good representation from units across England, and staff from the national Academic Health Science Network. We found that all units irrespective of whether they received a standard or enhanced QI package were successful in the ‘normative restructuring’ of their setting to enable magnesium sulphate to be administered. This suggests that this implementation outcome is necessary to achieve improvements. However, it may not be sufficient to sustain and normalise the changes once additional resources have been withdrawn. Sustainment, our findings suggest, required ‘relational restructuring’ to accommodate altered workflows and facilitate the sharing of responsibilities and tasks in daily practice. Relational restructuring was more likely to have been achieved units receiving enhanced QI support but also happened in units with standard QI support, especially in those where perinatal teamworking was already well established.
Conclusion
Unlike other large QI focused spread-and-scale programmes which failed to show any impact on outcomes, the PReCePT programme in both the enhanced and standard support packages led to improvements in the uptake of magnesium sulphate. The findings suggest that QI programmes interact with the enabling factors, such as strong interprofessional team working, already present in the setting. A standard package with minimal support was therefore sufficient in settings with enabling factors, but enhanced support was required in units where these were absent.
Changes in the South American Monsoon System since the Last Glacial Maximum
Authors: Custódio Igor Stivanelli , Dias Pedro Leite da Silva , Wainer Ilana , Prado Luciana F. 
Published: October 2022

Abstract
The main objective of this study is to investigate the spatial-temporal variability and the climate forcing influence during the last 21,000 years of the South American Monsoon System (SAMS). TraCE-21k simulations Full and Single Forcings experiments were used. The identification of spatial variability patterns associated to the core of monsoon region and the South Atlantic Convergence Zone (SACZ) patterns are based on multivariate EOF analysis (precipitation, humidity, zonal and meridional wind) which produces two main modes: the South American Large Scale Monsoon Index (LISAM) and the SACZ mode. The LISAM and SACZ modes show that the TraCE-21k represents the SAMS and SACZ patterns and the comparison to the 20th Century reanalysis EOF analysis show significant agreement. LISAM time series proved to be an important instrument to identify monsoon precipitation variability, consistent with the regime changes registered in climatic proxies. The freshwater pulses forcing in TraCE-21k is a determining factor for the observed changes in the precipitation regime, mainly for the periods between the Heinrich Stadial 1 and the Younger Dryas. The results show that the observed and modeled SACZ southward shift in the Late Holocene is mainly modulated by insolation changes, with stronger correlation observed since the Mid-Holocene period. Through wavelet analysis, it was noted that energy was transferred from low frequencies to high frequencies during Bolling Allerod for the full forcing and freshwater pulse experiments in the Northern Hemisphere, with the SAMS multidecadal variability increasing from the early Holocene with direct influences of orbital forcing and ice cover.
Turbulent Drag Reduction by Travelling Waves of Spanwise Lorentz Force
Authors: Yang Qiang , Chung Yongmann 
Published: October 2022

Abstract
Travelling waves induced by spanwise Lorentz force for skin-friction drag reduction are studied in the present work using direct numerical simulations, with particular focus on the streamwise and spanwise travelling waves. The overall picture of drag reduction in the ω+ − κx+ − κz+ parameter space is uncovered. It is found that both drag reduction maps for the streamwise and spanwise travelling waves are featured with a drag reduction (DR) region and a drag increase (DI) region. For the streamwise travelling wave of spanwise Lorentz force, the DR and DI regions are located in the same parameter regime compared to that of the streamwise travelling wave of spanwise wall velocity, while for the spanwise travelling wave, the DR variation at any fixed κz+ is similar to the spanwise oscillating Lorentz force. An exploration of the oblique travelling wave with an angle to the mean flow shows that the optimal drag reduction appears when the wave travels backward relative to the flow direction, and the “ribbon” structure is a general phenomenon appearing in all oblique travelling wave cases. The ensemble averaged positive and negative quasi-streamwise vortices become asymmetric when the travelling wave is imposed, and the near-wall high- and low-speed streaks are significantly twisted in the spanwise direction. Spanwise oscillation, streamwise and spanwise travelling waves share strong similarity in the statistics, energy spectra as well as turbulent structure modulation.
Morphological changes of large layer V pyramidal neurons in cortical motor-related areas after spinal cord injury in macaque monkeys
Authors: Takata Yu , Yamanaka Hajime , Nakagawa Hiroshi , Takada Masahiko 
Published: October 2022

Abstract
In primates, neurons giving rise to the corticospinal tract (CST) are distributed in several motor-related areas of the frontal lobe, such as the primary motor cortex (M1), the supplementary motor area (SMA), and the dorsal and ventral divisions of the premotor cortex (PMd, PMv). Recently, we have analyzed the morphology of basal dendrites of CST neurons, i.e., large layer V pyramidal neurons in macaque monkeys and shown that the complexity and spine density of the dendrites vary across the motor-related areas. Here, we investigated the alterations in basal dendrite morphology of CST neurons after spinal cord injury (SCI). In our SCI model, both the intersection number and the spine density of basal dendrites were highly decreased throughout the motor-related areas. Notably, these events were less prominent for the PMd than for the M1, SMA, and PMv. When we further compared the density changes post-SCI of the filopodia-, thin-, stubby-, and mushroom-type spines in individual areas, it was found that the density of filopodia-type (immature) spines was increased for all the areas, whereas the other types of spines exhibited their density reductions. Again, such spine density reductions were so limited for the PMd as compared to the M1, SMA, and PMv.
Mindfulness may reduce prosocial engagement among high intelligence individuals
Authors: Guo Qingke , Li Sisi , Liang Jingu , Yu Xinxin , Lv Yiqing 
Published: October 2022

Abstract
This study examined the role of dispositional mindfulness in the association between intelligence and prosocial behavior (PB). A total of 759 college students (mean age is 22.03; 477 females) participated in exchange for extra credit in psychology course. The results confirmed a positive relationship between intelligence and PB as revealed by many studies, with empathy playing a mediating role. Mindfulness negatively moderated all the hypothesized pathways between research variables. Specifically, with the increase of the levels of dispositional mindfulness (1) the intelligence-PB association changed from positive to negative, (2) the intelligence-empathy association changed from positively significant to insignificant, (3) the empathy-PB association changed from stronger to weaker. These findings may suggest some limitations of mindfulness. That is, present moment awareness and acceptance of the status quo may result in reduced arousal when witnessing others suffering thereby preventing high intelligence people from helping the sufferers get rid of trouble.
The HUJI Corpus of Spoken Hebrew: An interaction-oriented design of a corpus
Authors: Marmorstein Michal , Matalon Nadav 
Published: October 2022

Abstract
The paper reports on the creation of the HUJI Corpus of Spoken Hebrew (HUJICorpus) which documents naturally occurring speech and interaction in Modern Hebrew. Data come from telephone conversations recorded during the years 2020–2021. The focus on telephone conversations as a primary resource enables to reduce some of the semiotic complexity and concentrate on the linguistic (verbal and vocal) features of the interaction. Drawing on the principles of Interactional Linguistics, the recordings are transcribed using a highly granular system of formal annotation which accurately captures the temporal, sequential and prosodic aspects of talk-in-interaction. The audio files and transcripts were made freely accessible online, thus filling a widely acknowledged need for a publicly accessible and updated corpus of spoken Modern Hebrew.
Long-term systemic and mucosal humoral response in SARS- CoV-2 vaccinated post-Covid-19 infected patients
Authors: Sengupta Anirban , Azharuddin Mohammad , Johanna Edén , Daniel Aili , Selegård Robert , Naeimipour Sajjad , von Castelmur Eleonore , Wahlin Anna , Sunnerhagen Maria , Pietras Zuzanna , Patra Hirak K , Al-Otaibi Noha , Sigvardsson Mikael , Håkan Hanberger , Katarina Niward , Östholm-Balkhed Åse , Hinkula Jorma 
Published: October 2022

Abstract
Longitudinal serum samples, nasopharyngeal/nasal swabs and rectal swab samples were collected from eighty-nine individuals (median age 66 y) with SARS-CoV-2 PCR-positive test results at Linköping University Hospital. Samples were collected from the initial visit and thereafter for up to 2 years of follow-up. The presence of serum IgG and IgA against SARS-CoV-2 antigens (S1-spike, nucleocapsid, and NSP3) was analysed. Nasal and rectal swabs were tested for the presence of mucosal IgA against the outer envelope S1 spike and the nucleocapsid protein. Ninety percent of the participants were seropositive for SARS-CoV-2 recombinant proteins on Day 28 after study entry, and all (100%) were seropositive based on samples collected 2 months or later. Almost all (95%) developed serum SARS-CoV-2-neutralizing antibodies that were measurable from 6 to 24 months. The most common antibody responses (both serum IgG, mainly IgG1, and in nasal mucosa IgA) reacted with the S1-spike protein and the nucleoprotein. In samples collected from nasal tissues, IgA anti-S1 spike protein was mainly observed during 2 months of follow-up. In a subpopulation (18% of tested individuals), rectal IgA swabs showed the presence of anti-S1 spike IgA for 1 month of follow-up among the participants studied. .
Modification of TiO 2 nanotubes by graphene - strontium and cobalt molybdate perovskite for efficient hydrogen evolution reaction in acidic medium
Authors: Szkoda Mariusz , Ilnicka Anna , Skorupska Malgorzata , Wysokowski Marcin , Lukaszewicz Jerzy P. 
Published: October 2022

Abstract
Herein, we demonstrate that modification of TiO2 nanotubes with graphene-strontium and cobalt molybdate perovskite can turn them into active electrocatalysts for hydrogen evolution reaction (HER). For this purpose, a simple method of hydrothermal synthesis of perovskites was developed directly on the TiO2 nanotubes substrate. Moreover, the obtained hybrids were also decorated with graphene oxide (GO) during one-step hydrothermal synthesis. The obtained materials were characterized by scanning electron microscopy with energy dispersive X-ray analysis, Raman spectroscopy, and X-ray diffraction analysis. Catalytic properties were verified by electrochemical methods (linear voltammetry, chronopotentiometry). The obtained hybrids were characterized by much better catalytic properties towards hydrogen evolution reaction compared to TiO2 and slightly worse than platinum. The optimized hybrid catalyst (decorated by GO) can drive a cathodic current density of 10 mA cm−2 at an overpotential of 121 mV for HER with a small Tafel slope of 90 mV dec−1 in 0.2 M H2SO4.
Love-type waves in multilayered elastic media containing voids: Haskell matrix method
Authors: Kaur Savkirat , Khurana Aarti , Tomar S. K. 
Published: October 2022

Abstract
Propagation of Love-type waves is investigated in a model of multilayered elastic solid half-space containing voids. Using Haskell matrix method, the dispersion relations are derived for two situations of topmost boundary surface of the model: (a) when it is stress-free and (b) when it is rigid. For both the situations, there exist two wave fronts of Love-type waves that are dispersive in nature and propagating with distinct speeds. One of these wave fronts is analogous to that propagating through multilayered elastic half-space without voids, while the other front is new and appeared due to the presence of voids in the model. Conditions of propagation of both the wave fronts of Love-type waves are derived analytically for 2-layered model. Comparison of dispersion curves corresponding to both these fronts is also depicted graphically for 2-and 3-layered models with stress-free boundary surface. Effect of the thickness of layer and the presence of void parameters on the corresponding wave speeds is studied and depicted graphically for a specific 2-layered model.
Finite differences and quadratures: General formulae from deferred correction method
Authors: Koyaguerebo-Imé Saint-Cyr Elvi Rodrigue 
Published: October 2022

Abstract
In this paper deferred correction method is applied to derive explicitly different arbitrary high order finite difference (FD) formulae for the numerical differentiation of analytic functions. With this approach, various first and second order FD formulae are given with error terms explicitly expanded as Taylor series of the analytic function. These lower order approximations are successively improved by one or two to give FD formulae of arbitrary high order. The new approach efficiently recovers all the existing FD formulae on uniformly spaced grid points and the standard backward, forward and central FD formulae which are usually only given heuristically in terms of formal power series of FD operators. Examples of new FD formulae suited for timestepping schemes are built, and a stable self-starting time-stepping scheme of order four is provided to illustrate the application of the new FD approach to time-stepping method. The new approach extends to unequally spaced grid points and allows to Gaussian quadratures with exact error terms while it can also be used to correct high order Newton-Côte quadratures to quadratures with weights all positive. Contrary to existing quadrature rules, the new approach allows to a better approximation of the integral of a function f on an interval [a,b] using arbitrary given interpolation nodes within this interval.
Role of Preimplantation genetic testing in Indian women with advanced maternal age to optimize Reproductive Outcomes
Authors: mantravadi Krishna chaitanya , Rao Durga Gedela , Rawat Beena , Chauhan Pooja 
Published: October 2022

Abstract
PURPOSE
Does preimplantation genetic testing for aneuploidy (PGT-A) in embryos help women of advanced maternal age (AMA) achieve better reproductive outcomes?
METHODS
Multicenter, controlled retrospective study, a total of 267 patients (n = 267) were recruited, of which 53 patients (PGT-A group) consented to PGT-A, followed by euploid embryo transfer, whereas the remaining 214 patients (non-PGT-A group) underwent embryo transfer of un-screened morphologically graded blastocysts.
RESULTS
A significant increase in the clinical pregnancy rate was observed in the PGT-A group when compared to the non-PGT-A group (71.6% vs. 51%, p = 0.007), while the miscarriage rate was found to be lower in the PGT-A group compared to the non-PGT-A group (11% vs. 25%, p = 0.02). The live birth rates observed in either group were statistically nonsignificant (62.2% vs 51%, p = 0.14). In the PGT-A group, similarly, the implantation rate was found to be significantly higher than in the non-PGT-A group (53% vs. 33%, p = 0.007).
CONCLUSION:
The data suggest that PGT-A testing in women of advanced maternal age can improve their reproductive outcomes.