bluuebunny/crossref_metadata_2025_split huggingface dataset:
PIN1 As A Marker of Metastasis and Survival in Pancreatic Neuroendocrine Tumor Identified by Single-cell Sequencing and Proteomic Profiling
Authors: Wang Min , Yin Taoyuan , Huang Peiwu , Qin Tingting , Chen Dong , Xu Simiao , Gong Jun , Tian Ruijun , Guo Xingjun , Qin Renyi 
Published: December 2022

Abstract
Background
This study aimed to identify new protein markers that can evaluate the metastatic ability of Pancreatic neuroendocrine tumors (PanNETs) and predict prognosis together with Ki-67.
Methods
Multicentric series analysis was performed to evaluate the effect of metastasis on overall survival (N = 1,109). Single-cell RNA sequencing, proteomics (32 PanNETs and 10 normal pancreas tissues), and immunohistochemical staining (152 PanNETs) were conducted to screen proteins associated with PanNET metastatic capability. Associations between expression of screened proteins and survival were examined using Cox regression. In vitro experiments were performed to verify the function of candidate protein. A survival signature was constructed using recursive partitioning and survival forest analyses.
Results
The combination of G grade and metastasis predicted long-term survival more accurately though retrospective analysis. Single-cell RNA-seq highlighted the PanNET characteristics of metastasis that do not correspond with G grade and identified high metastatic capability subgroups in PanNET. Five proteins (PIN1, POSTN, SEMA4F, ASPN, and KCDT12), which may be related to the metastatic capability of PanNETs, were identified by proteomics. Random survival forest analysis showed that PIN1 could be a marker of PanNET metastatic ability. PIN1 overexpression promoted metastasis through LAMIN in PanNET cells. Finally, a survival signature with a consistency index of 0.921 and strong calibration was established, with good ability to predict patient survival.
Conclusion
In summary, we found that PIN1 can precisely evaluate the metastatic potential of PanNETs and, together with the proliferation marker Ki-67, can accurately predict the survival of PanNET patients.
Cancer patient and Caregiver Communication about Economic Concerns and the Effect on Patient and Caregiver Partners’ Perceptions of Family Functioning
Authors: Thomson Maria D. , Wilson-Genderson Maureen , Siminoff Laura A 
Published: December 2022

Abstract
Purpose: Financial strain and stressful life events predict poor family communication. A cancer diagnosis can bring heightened emotional stress and financial strain for most cancer patients and their families. We evaluated how level of comfort and willingness to discuss important but sensitive economic topics affected longitudinal assessments of family relationships, exploring both within-person and between partner effects over two years after a cancer diagnosis.
Methods: A case series of hematological cancer patient-caregiver dyads (n=171) were recruited from oncology clinics in Virginia and Pennsylvania and followed for 2 years. Multi-level models were developed to examine the associations between comfort discussing economic aspects of cancer care and family functioning.
Results: Broadly, caregivers and patients who were comfortable discussing economic topics reported higher family cohesion and lower family conflict. Dyads’ assessments of family functioning were influenced both by their own and their partners level of communication comfort. Overtime caregiver but not patients perceived a significant decrease in family cohesion.
Conclusions: Communicating about potentially delicate topics such as cancer care costs are associated with family functioning long term. Discussing employment in particular appears to be challenging for both members of the dyad.
Implications for Cancer Survivors: In this sample, cancer patients did not perceive the decline in family cohesion that was reported by their family caregiver. This is an important finding for future work that aims to identify the timing and nature to best intervene with caregiver supports to mitigate caregiver burden that may negatively impact long term patient care and QOL.
Dip-phenomenon and analytical model for velocity profile in open-channel bends
Authors: Hu Peng , Wu Di , Xiang Huawei , Yu Minghui 
Published: December 2022

AbstractThe dip-phenomenon whereby the location of the maximum velocity appears below the free surface is related to the advective momentum transport by secondary flow. In open-channel bends, there exist relatively large-scale vorticities termed Prandtl’s secondary flow of the first kind which is remarkably different from Prandtl’s secondary flow of the second kind induced by anisotropy of turbulence in straight channels. Experiments were carried out in a narrow and sharp bend to explore the dip-phenomenon along the bend. It is revealed that at the bend entrance the dip-phenomenon in the outer bank is more pronounced than that in the inner bank, while it is opposite in the rest region. The variation of the dip position reflects the momentum redistribution by the multiple circulation cells developed along the bend. Based on the Reynolds Averaged Navier–Stokes (RANS) equations with a cylindrical coordinate system and the experimental data, a new analytical model for the velocity profile in open-channel bends is proposed. The model verified by the experimental data is able to predict the dip position and velocity profile accurately in both the inner bank and outer bank regions. Two factors are discussed about the effect of the vertical velocity distribution and transverse gradient of secondary flow on the variation of the streamwise velocity profile.
Characteristics, sources, and exposure risk of the carbonaceous species of PM2.5 in Lahore, Pakistan
Authors: Ahmad Mushtaq , Chen Jing , Yu Qing , Lee Heekwan , Khan Muhammad Tariq , Ali Syed Weqas , Nawab Asim , Panyametheekul Sirima 
Published: December 2022

AbstractSamples of PM2.5are collected and analyzed in the urban areas of Lahore, Pakistan, during the sampling periods of the winter and summertime. The mass concentrations of PM2.5and its carbonaceous species (OC and EC) show a significant variation during both sampling periods. The mean OC concentration in winter and summertime are 50.7 ± 30.5 µg/m3, and 14.6 ± 5.6 µg/m3, whereas EC concentrations are 26.5 ± 18.0 µg/m3and 8.6 ± 3.4 µg/m3, respectively. In the winter and summertime, the OC/EC average ratios reported are 2.1 and 1.9, respectively. There is a strong OC-EC correlation in the wintertime, indicating that they have a common source. The weak OC-EC correlation in the summertime is attributed to increased biogenic emissions and secondary organic aerosol formation through photochemical processes. Secondary organic carbon (SOC) contributes 16.7% of organic carbon in the winter and 22.6% in the summertime sampling. The exposure risk of EC is estimated based on inhalation dose. The higher exposure risk of EC inhalation in winter can adversely affect human health. According to principal component analysis (PCA), the major sources of the carbonaceous species of PM2.5at Lahore included vehicle emission, secondary organic aerosol formation, emissions from combustion sources, and dust. The potential source contribution function (PSCF) and trajectory cluster analysis also demonstrated that the high concentrations of PM2.5and its carbonaceous species in Lahore resulted from regional and local pollution sources.
Geometry and Topology of Conceptual Representations of Simple Visual
Data
Authors: Dolgikh Serge 
Published: December 2022

Introduction:
Representations play an essential role in learning artificial and biological
systems by producing informative structures associated with characteristic patterns in the sensory
environment. In this work, we examined unsupervised latent representations of images of basic geometric
shapes with neural network models of unsupervised generative self-learning.

Background:
Unsupervised concept learning with generative neural network models.

Objective:
Investigation of structure, geometry and topology in the latent representations of generative
models that emerge as a result of unsupervised self-learning with minimization of generative
error. Examine the capacity of generative models to abstract and generalize essential data characteristics,
including the type of shape, size, contrast, position and orientation.

Methods:
Generative neural network models, direct visualization, density clustering, and probing
and scanning of latent positions and regions.

Results:
Structural consistency of latent representations; geometrical and topological characteristics
of latent representations examined and analysed with unsupervised methods. Development and verification
of methods of unsupervised analysis of latent representations.

Conclusion:
Generative models can be instrumental in producing informative compact representations
of complex sensory data correlated with characteristic patterns.
Real-Time Location, Correction and Segmentation Algorithm based on
Tilted License Plate
Authors: Gao Zhiyong , Xiang Jianhong 
Published: December 2022

Background:
Vehicles have become one of the most important means of transportation, and license plate is the only identifying mark of vehicles. License plate recognition technologies are being applied to a series of occasions, such as supervising road traffic violations, recovering stolen vehicles, monitoring wanted vehicles, and dispatching special vehicles. The license plate tilt phenomenon caused by various reasons has brought great trouble to its own recognition.

Objective:
How to identify tilted license plates efficiently and accurately becomes the key to the automatic management of a large number of vehicles. Therefore, a real-time location, correction and segmentation algorithm based on the tilted license plate is proposed in this paper.

Methods:
Firstly, an end-to-end deep convolutional neural network (CNN) is proposed for the location detection of the tilted license plate. The developed CNN is optimized by the most advanced RefineDet algorithm. By improving the object detection module, the representation ability of the CNN for small features and the accuracy of the detector are improved, so as to make the location regression and label prediction of the detected object more accurate. Secondly, the optimized perspective transformation algorithm is applied to correct the tilted license plate. According to the vertices coordinates of the bounding box detected by our CNN, the license plate area cropped out from the original image has a certain tilt angle, and the perspective transformation algorithm achieves the correction. Finally, digital image processing technology is used to segment the characters of license plates.

Results:
The experimental results in the Chinese City Parking (CCP) dataset show that the proposed algorithm exhibits location average precisions improvements of 2.4-5.4% over the other algorithm.

Conclusion:
The proposed algorithm achieves high-accuracy correction and real-time segmentation.
Impact of Gamification on Consumers’ Favorability in Cause-Related Marketing Programs: Between-Subjects Experiments
Authors: Li Yanhe , Li Yanchen , Zhou Xiu , Ma Kunshu 
Published: December 2022

Background
Successful cause-related marketing (CRM) campaigns can help companies stand out from their competitors; however, CRM may not have pleasant outcomes, even if it receives substantial investment.

Objective
This research aimed to investigate how gamified CRM projects influence consumers’ favorability.

Methods
We introduced 3 different CRM projects in 3 different studies. Every project had 2 versions according to the level of gamification, and participants were randomly assigned into these 2 groups. Additionally, we used a 2 (gamification: lower, higher) 2 (rules presentation: without visual cues, with visual cues) between-subjects design to test the moderation role of rules presentation in gamified CRM projects.

Results
In Study 1, we identified that the highly gamified CRM program induces more enjoyment (F1,139=21.11, P<.001) and higher favorability (F1,139=14.57, P<.001). Moreover, we found that enjoyment played a mediation role between gamification and favorability (P<.001) in Study 2. In addition, the results of Study 3 indicated rules presentation in a gamified CRM program can moderate the indirect effect of gamification on favorability via enjoyment (index of the moderated mediation: 95% CI –1.12 to –0.10; for rules presentation with visual cues: 95% CI 0.69 to 1.40; for rules presentation without visual cues: 95% CI 0.08 to 0.83).

Conclusions
Overall, this research contributes to the CRM literature and suggests gamification is an effective way of managing CRM campaigns.
Identifikasi dan Sosialisasi Potensi Desa di Era Informasi: PKM Multidisipliner di Dusun Gatak, Cangkringan, Yogyakarta
Authors: Dhewayani Jeanny 
Published: December 2022

In this Information Age, promoting village life and its potentialities can be delivered as interesting and useful content in digital media. In the effort to empower rural communities, communication technology such as mobile phones, which are relatively inexpensive and practical, can be employed to identify village potential, especially for young people. Not only interesting for the youth, but it can also involve them in community activities and give a meaning ful and greater experience. So, the main objective of this community service program is to assist the local youth in identifying the social condition and potentialities the village has by applying a research method that is easy, accurate, and friendly. Given the limited time available, the multidisciplinary team takes the Digital Humanity approach in the form of youth training as the type of activity implemented in this program. Accordingly, to provide research experience to participants, Rapid Rural Appraisal (RRA) is taken as the primary method in undergoing the activity.
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Di Era Informasi ini, mempromosikan kehidupan desa dan potensinya dapat dihadirkan sebagai konten yang menarik dan bermanfaat di media digital. Dalam upaya pemberdayaan kehidupan masyarakat pedesaan, teknologi komunikasi seperti telepon genggam yang relatif murah dan praktis dapat digunakan untuk mengidentifikasi potensi desa, khususnya bagi generasi muda. Ponsel tidak hanya menarik bagi kaum muda, tetapi juga dapat melibatkan mereka dalam kegiatan masyarakat dan memberikan pengalaman yang lebih bermakna dan lebih besar. Jadi, secara prinsip, tujuan utama dari program pengabdian masyarakat yang dilakukan secara multidisipliner ini adalah membantu pemuda desa setempat dalam mengidentifikasi kondisi sosial dan potensi yang dimiliki desa mereka dengan menerapkan metode penelitian yang mudah, akurat, dan menyenangkan. Mengingat keterbatasan waktu yang tersedia, pelatihan pemuda dipilih sebagai jenis aktivitas yang diterapkan oleh tim dalam program ini. Oleh karena itu, untuk memberikan pengalaman penelitian lapangan kepada peserta. Rapid Rural Appraisal (RRA) dijadikan sebagai metode utama dalam pelaksanakan kegiatan.
Digitalisasi Makam Penyiar Islam Raden Mas Suryodilogo di Pamboang Sulawesi Barat
Authors: Adawiah Rabiatul , Hasyim Ashari  , Ahmad Muaffaq  , Husna  , Nasrah  
Published: December 2022

Unlike the tombs of other Islamic broadcasters, the tomb of Raden Mas Suryodilogo has not received good attentions from the government and the public. The main purpose of this community service is to publish this historical site through digitization in the form of making a video and an infographic poster. This project is implemented from February to July 2022 using the Asset-based Community Development (ABCD) approach which emphasizes a community-driven element. The service team has carried out eight stages starting from team formation, training of trainers, appreciation interviews, asset mapping, observation and literature studies, FGD, making videos and posters, socialization to monitoring, and evaluation. In general, societies in Pamboang realize that they have assets and potential including religious tourism in the form of relics of Raden Mas Suryodilogo so the team did not find any obstacles when mapping assets. The community is also actively involved and willing to participate at the time of image taking and to disseminate information through the output of this PkM.
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Berbeda dengan makam tokoh penyiar Islam lainnya, makam Raden Mas Suryodilogo belum mendapat perhatian yang baik dari pemerintah dan masyarakat. Program pengabdian kepada masyarakat ini bertujuan memublikasikan situs bersejarah tersebut melalui digitalisasi berupa pembuatan video dan poster infografis. PkM ini dilaksanakan pada bulan Februari hingga Juli tahun 2022 dengan menggunakan pendekatan Asset based Community Development (ABCD) yang menekankan unsur community driven. Tim pengabdi telah melaksanakan delapan tahapan yang dimulai dari pembentukan tim, training of trainers, wawancara apresiasi, pemetaan aset, observasi dan studi pustaka, FGD, pembuatan video dan poster, sosialisasi, hingga monitoring dan evaluasi. Secara umum, masyarakat menyadari bahwa mereka memiliki aset dan potensi wisata termasuk wisata religi berupa peninggalan Raden Mas Suryodilogo sehingga tim tidak menemukan kendala pada saat pemetaan aset. Masyarakat juga terlibat aktif dan bersedia untuk berpatisipasi pada saat pengambilan gambar hingga penyebaran informasi melalui output dari PkM ini.
Pengaruh Pendidikan Kesehatan tentang Kepatuhan Pengobatan terhadap Dukungan Keluarga dengan Pasien Skizofrenia
Authors: Syamsiyah Nurlathifah , Mulyanti Mulyanti 
Published: December 2022

Background: Noncompliance with medication is a common concern among patients with schizophrenia. About half of schizophrenic patients who take medication do not take it as prescribed. The family has a crucial part in choosing on schizophrenia patients' care, including medication. The level of knowledge influences family support, furthermore, offering information through health education is one approach to boost knowledge.Objective: To determine how health education on medication compliance influenced family support in schizophrenia patients at Puskesmas Jetis II Bantul.Method: This study was a quasi-experimental with a one-group pre-posttest design. The study was applied on 20 family caregivers of schizophrenia patients at Puskesmas Jetis II during May 2021. Family support questionnaire that had been modified and tested for validity and reliability was applied for collecting data. Data analysis was performed using univariate and bivariate techniques (paired t test).Result: During the pre-test, 13 (65%) of respondents had good family support scores (average score = 67,25), furthermore in the post-test 17 (85%) of respondents had good family support scores (average score = 68,95). The p value for the bivariate analysis was 0,46 which was not statistically meaningful.Conclusion: The provision of health education about medication compliance in this research had no meaningful impact on family support.ABSTRAKLatar belakang: Masalah yang sering dihadapi oleh penderita skizofrenia adalah ketidakpatuhan minum obat. Sekitar 50% dari penderita skizofrenia yang melakukan pengobatan, tidak patuh minum obat. Keluarga mempunyai peranan sangat penting dalam memutuskan perawatan pasien skizofrenia, termasuk pengobatan. Tingkat pengetahuan memengaruhi dukungan keluarga, lebih jauh lagi cara untuk meningkatkan pengetahuan, yakni melalui pendidikan kesehatan.Tujuan: Mengetahui pengaruh pendidikan kesehatan tentang kepatuhan minum obat terhadap dukungan keluarga pada pasien skizofrenia di Puskesmas Jetis II Bantul.Metode: Penelitian ini merupakan jenis quasi eksperimen dengan rancangan one group pretest dan posttest. Responden penelitian yaitu 20 orang keluarga pasien skizofrenia di wilayah kerja Puskesmas Jetis II, selama bulan Mei 2021. Instrumen yang digunakan berupa instrumen dukungan keluarga yang telah dimodifikasi, serta diuji validitas dan reliabilitasnya. Analisis data dilakukan secara univariat dan bivariat (paired t test).Hasil: Sebanyak 13 (65%) responden memiliki nilai dukungan keluarga yang baik (nilai rerata = 67,25) pada saat pretest. Kemudian pada posttest terdapat 17 (85%) responden dengan nilai dukungan keluarga yang baik pula (nilai rerata = 68,95). Hasil analisis menunjukkan, bahwa nilai p = 0,46 yang artinya tidak bermakna secara statistik.Simpulan: Pemberian pendidikan kesehatan tentang kepatuhan minum obat pada penelitian ini tidak berpengaruh secara signifikan terhadap dukungan keluarga.
THE ANTIDEPRESSANT ACTIVITY OF MUNTINGIA CALABURA L. LEAVES ETHANOL EXTRACT IN MALE SWISS-WEBSTER MICE
Authors: RAHAYUNINGSIH NUR , FADHILA SYIFA NUR , CAHYATI KENI IDA 
Published: December 2022

Objective: The purpose of this study was to determine the activity and optimal dose of Muntingia calabura L. ethanol extract as an antidepressant using Forced Swimming Test (FST), Tail Suspensions Test (TST), and Open Field Test (OFT).
Methods: Twenty-five male Swiss-Webster mice were randomly divided into five groups. Group 1 as a control group, got vehicle (1% w/v CMC). As a positive control, group 2 got 0.052 mg/20 g mice BW of fluoxetine. Groups 3-5 received 0.7, 1.4, and 2.8 mg/20 g mice BW orally of M. calabura leaves extract. In the FST and TST, immobility time was the test parameter. In the OFT, the test parameters were the grooming duration, the duration of entries into the central square, and the duration of rearing.
Results: The results showed that all test dose groups had antidepressant activity and test dose 3 was the optimal dose marked by a decreasing in immobility time in the FST and TST with an average percentage decrease of 33.70 % and 13.95%. In the OFT method, it is characterized by increasing in the average percentage of the duration of central square and rearing by 63.46% and 76.25%, respectively and a decreasing in the average percentage of grooming duration by 27.57%.
Conclusion: From these results show ethanol extract of M. calabura leaves has antidepressant activity and the test dose of 3 (2.8 mg/20 g mice BW) is the optimal test dose.
NATURAL INHIBITOR OF AGRONOMICALLY REPELLENT PLANT TOWARDS CLINICAL ISOLATE OF CHLORAMPHENICOL RESISTANT-SALMONELLA TYPHI
Authors: KUSUMA SRI AGUNG FITRI , HERAWATI IRMA ERIKA , RAMDHANI DANNI , MAULANA BAGUS 
Published: December 2022

Objective: This study was purposed to determine the most effective inhibition among those repellent plants i.e. The leaves of kirinyuh (Chromolaena odorata), kenikir (Cosmos caudatus), bandotan (Ageratum conyzoides), grass teki (Cyperus Cyperus rotundus), lemongrass (Cymbopogon citratus) and suren (Toona sureni) towards S. typhi clinical isolate.
Methods: The ethanolic extracts of sixt plants were obtained by maceration method using 70% ethanol. Phytochemical screening was done using the standard methods as described by Farnsworth. The inhibition of the repellent leaves ethanolic extracts to chloramphenicol resistant-S. typhi clinical isolate assayed using the agar diffusion method and statistically analyzed by ANOVA followed by the Duncan test. The most potential plant was further determined by investigating the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) value using the microdilution test.
Results: As the result, all ethanolic leaves extracts contain alkaloids, flavonoids, and tannins, except that tannins were not found in C. rotundus and A. conyzoides. However, all extracts had the activity to inhibit the growth of S. typhi. T. sureni leaves extract evidently showed the strongest inhibition with MIC value in the range of 1.5625<x≤3.125 mg/ml and the MBC value in the range of 6.25<x≤12.5 mg/ml. The ratio of MBC/MIC≤4, thus, T. sureni leaf extract may be classified as a strong bactericidal agent.
Conclusion: In summary, T. sureni extract leaves achieved the most appreciable value of MIC MBC and considered as the bactericidal agent which has strong potential to be a novel anti-typhoid fever agent.