bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of the combination of photobiomodulation therapy and the intralesional administration of corticoid in the preoperative and postoperative periods of keloid surgery: A randomized, controlled, double-blind trial protocol study
Authors: Pires Jefferson André , Bragato Erick Frank , Momolli Marcos , Guerra Marina Bertoni , Neves Leonel Manea , de Oliveira Bruscagnin Meire Augusto , Ratto Tempestini Horliana Anna Carolina , Porta Santos Fernandes Kristianne , Kalil Bussadori Sandra , Agnelli Mesquita Ferrari Raquel 
Published: February 2022

Keloid scars are characterized by the excessive proliferation of fibroblasts and an imbalance between the production and degradation of collagen, leading to its buildup in the dermis. There is no “gold standard” treatment for this condition, and the recurrence is frequent after surgical procedures removal. In vitro studies have demonstrated that photobiomodulation (PBM) using the blue wavelength reduces the proliferation speed and the number of fibroblasts as well as the expression of TGF-β. There are no protocols studied and established for the treatment of keloids with blue LED. Therefore, the purpose of this study is to determine the effects of the combination of PBM with blue light and the intralesional administration of the corticoid triamcinolone hexacetonide on the quality of the remaining scar by Vancouver Scar Scale in the postoperative period of keloid surgery. A randomized, controlled, double-blind, clinical trial will be conducted involving two groups: 1) Sham (n = 29): intralesional administration of corticoid (IAC) and sham PBM in the preoperative and postoperative periods of keloid removal surgery; and 2) active PBM combined with IAC (n = 29) in the preoperative and postoperative periods of keloid removal surgery. Transcutaneous PBM will be performed on the keloid region in the preoperative period and on the remaining scar in the postoperative period using blue LED (470 nm, 400 mW, 4J per point on 10 linear points). The patients will answer two questionnaires: one for the assessment of quality of life (Qualifibro-UNIFESP) and one for the assessment of satisfaction with the scar (PSAQ). The team of five plastic surgeons will answer the Vancouver Scar Scale (VSS). All questionnaires will be administered one, three, six, and twelve months postoperatively. The keloids will be molded in silicone prior to the onset of treatment and prior to excision to assess pre-treatment and post-treatment size. The same will be performed for the remaining scar at one, three, six, and twelve months postoperatively. The removed keloid will be submitted to histopathological analysis for the determination of the quantity of fibroblasts, the organization and distribution of collagen (picrosirius staining), and the genic expression of TGF-β (qPCR). All data will be submitted to statistical analysis.
Trial registration: This study is registered in ClinicalTrials.gov (ID: NCT04824612).
Effects of physical activity interventions using wearables to improve objectively-measured and patient-reported outcomes in adults following orthopaedic surgical procedures: A systematic review
Authors: Master Hiral , Bley Jordan A. , Coronado Rogelio A. , Robinette Payton E. , White Daniel K. , Pennings Jacquelyn S. , Archer Kristin R. 
Published: February 2022

Objective
To synthesize evidence on physical activity interventions that used wearables, either alone or in combination with education or rehabilitation, in adults following orthopaedic surgical procedures.

Methods
PubMed, CINAHL, PsycINFO and EMBASE were searched for randomized controlled trials of wearable-based interventions from each database’s inception to August 2021 in patients undergoing orthopaedic surgery. Relevant outcomes included physical activity, physical function, pain, psychological distress, or general health. PEDro scale scoring ranges from 0 to 10 and was used to appraise studies as high (≥7), moderate (5–6), or poor (<5) quality.

Results
Of 335 articles identified, 6 articles met eligibility criteria. PEDro scores ranged from 2 to 6, with 3 studies of moderate quality and 3 of poor quality. Studies included patients undergoing total knee (number; n = 4) or total knee or hip (n = 1) arthroplasty and lumbar disc herniation surgery (n = 1). In addition to wearables, intervention components included step diary (n = 2), motivational interviewing (n = 1), goal setting (n = 2), tailored exercise program (n = 2), or financial incentives (n = 1). Interventions were delivered in-person (n = 2), remotely (n = 3) or in a hybrid format (n = 1). Intervention duration ranged from 6 weeks to 6 months. Compared to controls, 3 moderate quality studies reported greater improvement in steps/day; however, 1 moderate and 2 poor quality studies showed no between-group difference in physical function, pain, or quality of life. No serious adverse events related to the use of wearable were reported.

Conclusions
The effects of physical activity interventions using wearables, either delivered in-person or remotely, appear promising for increasing steps per day after joint arthroplasty; however, this finding should be viewed with caution since it is based on 3 moderate quality studies. Further research is needed to determine the therapeutic effects of using wearables as an intervention component in patients undergoing other orthopaedic surgical procedures.

Trial registration
PROSPERO Registration Number: CRD42020186103
Young adults’ needs when seeking first-line healthcare: A grounded theory design
Authors: Viktorsson Lisa , Törnvall Eva , Falk Magnus , Wåhlin Ingrid , Yngman-Uhlin Pia 
Published: February 2022

BackgroundHealthcare outpatient visits have increased in recent years, and young adults are often given as an explanatory factor for many avoidable visits.ObjectiveThe objective of this study was to explore how young adults perceive seeking first-line healthcare.Design and settingThe study utilized a grounded theory design with data collection at primary healthcare centres and emergency departments in southeast Sweden.MethodData were collected during individual interviews and patient observations with subsequent interviews during the years 2017–2018. The analysis was performed using grounded theory.ResultsThe main concern when young adults are seeking healthcare is that their worries are taken seriously. It is a four-part process: becoming aware of, verifying, communicating, and receiving an opinion about one’s symptoms. The process includes external factors, clarity of symptoms, behavioural approaches, healthcare know-how, enabling self-management, and prior healthcare experience(s). When communicating symptoms, the clearer the symptoms, the less there needs to be communicated. When symptoms are unclear, the importance of different behavioural approaches and healthcare know-how increases. When receiving a medical opinion about symptoms, young adults want to learn how to self-manage their symptoms. Depending on previous healthcare experience, the healthcare visit can either harm or help the patient in their healthcare-seeking process.ConclusionThis study reflects several insights in the healthcare-seeking process from a young adult perspective. Based on the results, we suggest that healthcare providers focus on the final step in the healthcare-seeking process when giving their medical opinion about symptoms. Having extra minutes to give support for future self-care regardless of diagnosis could increase positive healthcare experiences and increase future self-care among young adults.
Prevalence and determinants of care needs among older people in Ghana
Authors: Awuviry-Newton Kofi , Ofori-Dua Kwadwo , Deku Charles Selorm , Abekah-Carter Kwamina , Awortwe Victoria , Oti George Ofosu 
Published: February 2022

Introduction
Given the longevity noticed among older people in Ghana, and the potential occurrence of functional disability in later years of life, it has become essential to understand their care needs. This study examined the care needs in daily tasks and associated factors in Ghana, following the World Health Organisation International Classification of Functioning, Disability and Health framework.

Materials and methods
A cross-sectional survey was conducted among a sample of 400 older people from Komfo Anokye Teaching Hospital in Southern Ghana. Care need was assessed by one question; “Do you regularly need help with daily tasks because of long-term illness, disability, or frailty?” Multivariate logistic regression was used to test the association between care need and independent variables based on the WHO-ICF conceptual framework.

Results
Majority of the sample (81%), particularly women (54%) reported needing care in daily tasks. Per the WHO-ICF conceptual framework, functional disability—activity variable, (OR = 1.07 95%CI: 1.05–1.09, p<0.001), and absence of government support—an environmental factor, (OR = 3.96 95%CI: 1.90–8.25, p<0.001) were associated with care need.

Conclusions
The high prevalence of care needs among older people may offer an indication that majority of older people in Ghana could benefit from long-term care services. Functional disability and the absence of government support are the major issues that need to be prioritised in addressing the increased demand for care related to performing daily tasks among older people in Ghana.
Neonatal Intestinal Obstruction Due to Kaposiform Hemangioendothelioma of the Jejunum
Authors: Maddileti Varunkumar , Mammen Abraham , Kuruvilla Shalini 
Published: February 2022

ABSTRACT
Kaposiform hemangioendothelioma is a borderline vascular tumor usually seen in infants and children as cutaneous lesions classically associated with the Kasabach-Merritt phenomenon. Intestinal involvement is uncommon and can cause acute presentations, such as obstruction or gastrointestinal bleeding. A 5-day-old neonate presented with bilious vomiting for 2 days. The tumor was in the jejunum. Histopathological examination with immunohistochemistry of the resected jejunum showed CD34 positive endothelial lined vascular spaces infiltrating from submucosa to serosa, which is classical of kaposiform hemangioendothelioma. There was no deranged coagulation profile. This case forms an interesting cause for neonatal intestinal obstruction.
Intraepithelial and lamina propria lymphocytes do not correlate with symptoms or exposures in microscopic colitis
Authors: Sandler Robert S. , Hansen Jonathan J. , Peery Anne F. , Woosley John T. , Galanko Joseph A. , Keku Temitope O. 
Published: February 2022

ABSTRACT

BACKGROUND:
Microscopic colitis, a common cause of diarrhea, is characterized by a largely normal appearance of the mucosa but increased numbers of lymphocytes in the epithelium and lamina propria on microscopy. We sought to determine whether T cell percentage was associated with exposures or symptoms.
METHODS
We conducted a case-control study that enrolled patients referred for colonoscopy for diarrhea. Patients were classified as microscopic colitis cases or controls by an experienced pathologist. Participants provided information on symptoms and exposures during a telephone or internet survey. Research biopsies from the ascending and descending colon were examined using immunofluorescence stains for CD3, CD8, and FOXP3 to determine percent T cells per total epithelial or lamina propria cells. Digital images were analyzed by region of interest using Tissue Studio.
RESULTS
There were 97 microscopic colitis cases and 165 diarrhea controls. There was no association between demographic factors and percentage of intraepithelial or lamina propria T cells. In cases, the mean percent T cells was similar in the right and left colon. There was no association between mean percent T cells and stool frequency or consistency. There was no association with irritable bowel syndrome, abdominal pain, or medications purported to cause microscopic colitis.
CONCLUSION
The lack of association between the density of T cells and medications raises further doubts about their role in disease etiology. Loose and frequent stools in patients with microscopic colitis are not correlated with T-cell density.
IbDM tentang Literasi Media bagi Pemilih Perempuan Jelang Pemilu Langsung 2019
Authors: Anggraini Oktiva 
Published: February 2022

Kegiatan pengabdian pada masyarakat ini ditawarkan sebagai solusi akan minimnya akses teknologi informasi serta rendahnya pemahaman pada persoalan hoax dan info pemilu 2019. Hal ini berawal dari kondisi pre survey pengabdi bahwa di lokasi desa mitra, yakni di kecamatan Umbulharjo. Menjelang pemilu langsung Presiden tahun 2019, sebagai salah satu kecamatan terbesar kota Yogyakarta, Umbulharjo tak luput dari sasaran fenomena hoax. Pemilih perempuan mudah dipengaruhi secara emosional. Di samping itu, rata-rata perempuan memiliki pendidikan lebih rendah dari laki-laki, akses terhadap infromasi politik pun lebih rendah. Mengingat lebih seringnya emosi yang mendominasi sehingga perempuan sering tidak sadar untuk menahan diri menyebarkan hoax. Berdasarkan latar belakang tersebut, hal yang menarik persoalan yang dijumpai di lokasi mitra: kurangnya pemahaman politik perempuan, hoax sulit ditangkal oleh masyarakat dan kurangnya kesadaran warga untuk menahan diri menyebarkan hoax tanpa sadar. Berangkat dari akar permasalahan tersebut, tim IbDM UWMY menawarkan solusi berupa literasi media yang sejalan dengan keseriusan pemerintah untuk menciptakan situasi politik yang kondusif jelang pemilu langsung Presiden Indonesia tahun 2019. Pendekatan yang dilakukan pada program aksi yakni Model Partisipatory Rural Appraisal (PRA), dengan teknik penyuluhan dan praktek.Digiatkannya gerakan literasi digital menjadi penting sebagai upaya menyadarkan masyarakat tentang peningkatan penguasaan teknologi digital dan alat komunikasi untuk mengakses, menerima, menganalisis dan mengevaluasi informasi dengan efektif. Dengan Gerakan Literasi Digital ini, masyarakat dilatih untuk mengoptimalkan kebaikan bermedsos, mengakses informasi yang positif serta mengajak masyarakat bersikap kritis dalam menerima informasi.
ANALISIS STRATEGI DIGITAL MARKETING PRODUK INDUSTRI KREATIF DI KECAMATAN RAJAPOLAH, TASIKMALAYA
Authors: Risdiana Aris 
Published: February 2022

Kecamatan Rajapolah memiliki potensi produk industri kreatif yang melimpah. Namun potensi ini belum sepenuhnya dapat diberdayakan. Pasalnya, para perajin masih kesulitan untuk menjual produknya. Oleh karena itu, diperlukan strategi pemasaran yang termanajerial dengan baik, sehingga harapannya dapat menghasilkan income yang signifikan bagi para perajin. Berdasarkan hal tersebut, UIN Sunan Kalijaga Yogyakarta sebagai lembaga yang bergerak dalam bidang pengembangan ilmu pengetahuan menjadikan kecamatan Rajapolah sebagai laboratorium sosial-ekonomi. Dengan memberikan pelatihan dan pendampingan digital marketing yang tujuannya sebagai strategi meningkatkan signifikasi pemasaran produk dari industri kreatif di kecamatan Rajapolah. Adapun program kerja UIN Sunan Kalijaga yang dilaksanakan berupa pelatihan, dengan tahapan sebagai berikut: (1) tahap persiapan, (2) tahap pelaksanaan proses dan (3) tahap pemandirian. Kegiatan program kerja ini dilaksanakan pada bulan Juli – Agustus 2019 yaitu berupa kegiatan: pendidikan dan pelatihan digital marketing. Beberapa manfaat praktis yang diharapkan dari pelaksanaan program kerja ini, antara lain: (1) masyarakat mendapatkan informasi yang utuh dan jelas tentang hakekat digital marketing sebagai strategi pemasaran yang efektif; (2) para perajin dapat menyusun strategi digital marketing untuk produk industri kreatif melalui pemanfaatan media sosial dan digital; (3) masyarakat dapat mengakses peluang-peluang pengembangan usaha mereka melalui digital marketing yang dapat mendatangkan nilai finansial. Dengan demikian, penelitian ini merupakan penelitian kualitatif yang berusaha menganalisis strategi digital marketing dengan fokus pada program yang dimotori dan dibimbing secara langsung oleh UIN Sunan Kalijaga dalam kaitannya untuk meningkatkan kualitas produk dan pemanfaatan digital marketing oleh masyarakat desa di era revolusi industri 4.0 yang berdasar pada community based research (CBR).diharapkan dari pelaksanaan program kerja ini, antara lain: (1) masyarakat mendapatkan informasi yang utuh dan jelas tentang hakekat digital marketing sebagai strategi pemasaran yang efektif; (2) para perajin dapat menyusun strategi digital marketing untuk produk industri kreatif melalui pemanfaatan media sosial dan digital; (3) masyarakat dapat mengakses peluang-peluang pengembangan usaha mereka melalui digital marketing yang dapat mendatangkan nilai finansial. Dengan demikian, penelitian ini merupakan penelitian kualitatif yang berusaha menganalisis strategi digital marketing dengan fokus pada program yang dimotori dan dibimbing secara langsung oleh UIN Sunan Kalijaga dalam kaitannya untuk meningkatkan kualitas produk dan pemanfaatan digital marketing oleh masyarakat desa di era revolusi industri 4.0 yang berdasar pada community based research (CBR).
Moderasi Relasi Lintas Agama Tau Samawa (Orang Sumbawa) Berbasis Keseharian di Tana Sumbawa
Authors: Funay Yaspis Edgar 
Published: February 2022

This paper will analyze the interfaith relations based on people’s daily life patterns in Tana Sumbawa. Deeper, the author tries to see how a cultural-based lifestyle in society can also be one of the strengths and the closest way out to maintain community relations when they want to conflict or create post-conflict reconciliation. This paper draws a tentative conclusion that the original culture of the Sumbawa people can be a reconciliation of ideological conflicts and strengthen collective awareness because they have ethical values, morals, and good behavior as local products. Using a sociological perspective this paper examines the extent to which cultural values play a role in interfaith relations in Sumbawa. In the final part, this paper will explore the concept of Sumbawa culture as outlined in local philosophy as a concept of tolerance between religious communities in order to maintain the existence of the local cultural heritage.
Case report of a novel mutation in Bruton’s tyrosine kinase gene with confirmed agammaglobulinemia and absent B lymphocytes
Authors: Bedaiwy Nouf , Alhamdi Shatha , Al Suwairi Wafaa , Alsalamah Mohammad 
Published: February 2022

Background: X-linked agammaglobulinemia type 1 (XLA) is one of the most common pediatric inborn errors of immunity affecting the humoral immune system. The condition is caused by a mutation in the Bruton’s tyrosine kinase gene (BTK), located in the long arm of the X-chromosome. BTK is crucial for B lymphocyte differentiation and activation. Therefore, a defect in BTK results in B lymphocyte maturation arrest, absence of plasma cells, and failure of immunoglobulin production. XLA affected individuals present with a history of frequent severe pyogenic infections such as pneumonia, conjunctivitis, otitis media, and bacteremia. Laboratory evaluation classically reveals undetectable immunoglobulins and the absence of B cells. The mainstay treatment is immunoglobulin replacement which can be administered intravenously (IVIG) or subcutaneously (SCIG). Aggressive antimicrobial treatment is also administered to reduce complications such as bronchiectasis or invasive bacterial infections during active infections. Aim: To report the clinical presentation, immune features, and genetic mutation in a case of a four-year-old boy with a novel mutation in the BTK gene leading to XLA. Results: The patient’s chart was reviewed. We describe the phenotypical and diagnostic characteristics of an established case in a four-year-old boy who suffered from recurrent infections. Genetic analysis revealed a pathogenic novel mutation in the BTK gene (c.1953C>A; p.Tyr651*), while flow cytometry found 0% CD19+ (B cells), and low serum Ig levels. Discussion: We report the clinical presentation, immune features, and genetic mutation in a patient with a novel mutation in the BTK gene causing XLA. Genetic analysis along with patient history, physical examination, and laboratory results are necessary to identify and diagnose XLA associated with pathogenic mutations in the BTK gene. Statement of novelty: We present an established case of a novel mutation in the BTK gene (c.1953C>A; p.Tyr651*), based on genetic analysis, absent CD19+cells (B cells), and low Ig serum levels.
Zcchc12-Containing Nociceptors Are Required for Noxious Heat Sensation
Authors: Wu Dan , Chen Yan , Li Zhen , Xie Hong , Wang Sashuang , Lu Yingjin , Bao Lan , Zhang Xu , Li Changlin 
Published: February 2022

DRG neurons are classified into distinct types to mediate the somatosensation with different modalities. Recently, transcriptional profilings of DRG neurons by single-cell RNA-sequencing have provided new insights into the neuron typing and functional properties. Zinc-finger CCHC domain-containing 12 (Zcchc12) was reported to be the representative marker for a subtype of galanin-positive (Gal+) DRG neurons. However, the characteristics and functions ofZcchc12+neurons are largely unknown. Here, we genetically labeledZcchc12+neurons inZcchc12-CreERT2::Ai9 mice, and verified thatZcchc12represented a new subpopulation of DRG neurons in both sexes.Zcchc12+neurons centrally innervated the superficial laminae in spinal dorsal horn, and peripherally terminated as free nerve endings in the epidermis and cluster-shaped fibers in the dermis of footpads and nearby. In addition,Zcchc12+neurons also formed circumferential endings surrounding the hair follicles in hairy skin. Functionally,in vivocalcium imaging in DRGs revealed thatZcchc12+neurons were polymodal nociceptors and could be activated by mechanical and noxious thermal stimuli. Behavioral tests showed that selective ablation ofZcchc12+DRG neurons reduced the sensitivity to noxious heat in mice. Together, we identified a new subpopulation ofZcchc12+nociceptors essential for noxious heat sensation.SIGNIFICANCE STATEMENTZcchc12represents a new subpopulation of DRG neurons. The characteristics and functions ofZcchc12+neurons are largely unknown. Here we genetically labeledZcchc12+neurons, and showed that the fibers ofZcchc12+DRG neurons projected to superficial lamina at spinal dorsal horn, and innervated skin as free nerve endings in the epidermis and cluster-shaped fibers in the dermis of footpads and nearby. Functionally,Zcchc12+DRG neurons responded to noxious mechanical and heat stimuli. Ablation ofZcchc12+DRG neurons impaired the sensation of noxious heat in mice. Therefore, we identify a new subpopulation of DRG neurons required for noxious heat sensation.
Conceptual Change Texts to Improve Teachersâ€™ Misconception at Verbal and Visual Representation on Heat Conduction Concept
Authors: Anam R. S. , Widodo A. , Sopandi W. 
Published: February 2022

Heat Conduction is a scientific concept that related to daily life. Learning about heat conduction is usually only discussed at the macroscopic level, whereas at the sub-microscopic level never be a concern from elementary students until to the teachers. This study aims to identify the effect of using Conceptual Change Text on the teacher's representation on the Â heat conduction concept. A quasi-experimental method using a one-group pretest-posttest design was used in this study. The instrument was a diagnostic test, the data were analyzed from the comparison of participants' representations (5 elementary teachers) before and after treatment, the results showed that teacher representation was better after treatment. This research also reinforces that the representation of the sub-microscopic level is an important aspect of the learning process. Science learning needs to be developed and equipped up to the sub-microscopic level both verbal or visual to make science lessons more meaningful and easily understood by students.