bluuebunny/crossref_metadata_2025_split huggingface dataset:
SARS CoV-2 Genomic Characteristics and Clinical Impact of SARS-CoV-2 Viral Diversity in Critically Ill COVID-19 Patients: A Prospective Multicenter Cohort Study
Authors: Fourati Slim , Audureau Etienne , Arrestier Romain , Marot Stéphane , Dubois Claire , Voiriot Guillaume , Luyt Charles-Edouard , Urbina Tomas , Mayaux Julien , Roque-Afonso Anne-Marie , Pham Tai , Landraud Luce , Visseaux Benoit , Roux Damien , Bellaiche Raphael , L’honneur Anne-Sophie , Hamou Zakaria Ait , Brichler Ségolène , Gaudry Stéphane , Salmona Maud , Clere-Jehl Raphaël , Azoulay Elie , Joubert Laurence Morand , Marcelin Anne-Geneviève , Chaix Marie-Laure , Descamps Diane , Dessap Armand Mekontso , Rodriguez Christophe , Pawlotsky Jean-Michel , de Prost Nicolas 
Published: January 2022

Abstract
Background: SARS-CoV-2 variant of concern (VOC) α spread worldwide, including in France, at the beginning of 2021. This variant was suggested to be associated with a higher risk of mortality than other variants. Little information is available in the subset of patients with severe disease admitted in the intensive care unit (ICU). We aimed to characterize the genetic diversity of SARS-CoV-2 variants isolated from patients with severe COVID-19 in order to unravel the relationships between specific viral mutations/mutational patterns and clinical outcomes.Methods: Prospective multicentre observational cohort study. Patients aged ≥18 years admitted in 11 ICUs from Great Paris area hospitals between October 1, 2020, and May 30, 2021 (before the introduction of VOC δ (B.617.2) in France) for acute respiratory failure (SpO2≤90% and need for supplemental oxygen or ventilator support) were included. SARS-CoV-2 infection, determined by RT-PCR testing. The primary clinical endpoint was day-28 mortality. Full-length SARS-CoV-2 genomes were sequenced by means of next-generation sequencing (Illumina COVIDSeq).Results: 413 patients were included, 183 (44.3%) had been infected with pre-existing variants, 197 (47.7%) with variant α (B.1.1.7), and 33 (8.0%) with other variants. Patients infected with pre-existing variants were significantly older (64.9±11.9 vs 60.5±11.8 years; p=0.0005); they had significantly more frequent COPD (11.5% (n=21/183) vs 4.1% (n=8/197); p=0.009), and higher SOFA score (4 [3-8] vs 3 [2-4]; 0.0002). Day-28 mortality was not different between patients infected with pre-existing, α (B.1.1.7) or other variants (31.1% (n=57/183) vs 26.2% (n=51/197) vs 30.3% (n=10/33), respectively; p=0.550). There was no association between day-28 mortality with a specific variant or the presence of specific mutations in SARS CoV-2 genome, including 17 mutations selected in the spike protein and all 1017 non-synonymous mutations detected throughout the entire viral genome.Conclusions: At ICU admission, patients infected with pre-existing variants had a different clinical presentation from those infected with variant α (B.1.1.7) and other variants later in the course of the pandemic, but mortality did not differ between these groups. There was no association between a specific variant or SARS CoV-2 genome mutational pattern and day-28 mortality.
Nuclear magnetic resonance in chemical structures authentication and pyrolysis oil characterization
Authors: Liu Fanxin , Zeng Wujun , Wei Yinglei 
Published: January 2022

Abstract
Nuclear Magnetic Resonance (NMR) involves the study of nuclei immersed in a static magnetic field and exposed to a second oscillating field. Nuclei have two properties; spin properties and charge properties. Pyrolysis oil is created by dry heating biomass in a reactor without oxygen to around 500 degrees Celsius and then cooling it. Pyrolysis oil is a type of tar that includes too much oxygen to be classified as a pure hydrocarbon. One of the most fundamental methods in synthetic chemistry is using NMR to verify chemical structure. In the literature, little attention has been paid to the application of NMR in the authentication of chemical structures. In this study, we present a use case of NMR to characterize pyrolysis oil and authenticate chemical structures. Results show that the elucidation of chemical compositions of bio-oil is essential for the optimization of its processing technology and exploration of its potential application.
Distribution and phenology of monarch butterfly larvae and their milkweed hosts in the South Central US
Authors: Tracy James L , Kantola Tuula , Baum Kristen A. , Coulson Robert N. 
Published: January 2022

Abstract
South Central US milkweeds (Asclepias) are critical adult nectar and larval food resources for producing the first spring and last summer/fall generations of declining eastern migratory monarch butterflies (Danaus plexippus). This study addresses multiple gaps in assessment of monarch conservation priorities for the South Central US through analyses of monarch larval host selectivity, phenology, and spatial density, as well as the phenology, niche modeled distribution, and land cover selectivity of important milkweed hosts. Results are synthesized to estimate seasonal milkweed resource areas. About 70% of monarch larval activity occurred from mid-March to mid-July (early season) and 30% from mid-August to late November (late season). Twenty-six wild milkweed (Apocynaceae) hosts were mapped, including four new records for North America. Important hosts included Asclepias a. ssp. capricornu, A. viridis, and A. oenotheroides, that were utilized more frequently during early season, and Asclepias latifolia, utilized more frequently during late season. Landscape host selectivity was positive for A. viridis and A. a. ssp. capricornu in late and early seasons, respectively, and negative for A. oenotheroides in late season. Milkweed land cover selectivity was positive for Developed-Open Space and Grassland Herbaceous, and negative for Cultivated Crops and Shrub/Scrub. Seasonal milkweed resource areas and larval spatial densities resolved interior and coastal corridors providing functional connectivity for monarch spring and fall migrations. A potential gap in milkweed land cover benefit was identified in South Texas. The novel merging of milkweed niche models with larval phenology, host selectivity, milkweed phenology, and land cover selectivity informs conservation assessment.
Kekerasan Non-fisik Media pada Artis Gisella Anastasia (Analisis Wacana Kritis Sara Mills)
Authors: Bungsu Agung Pangeran 
Published: January 2022

Abstract: The increasing violence against women makes the issue of gender will continue to be interesting to study. The forms of violence committed against women are also increasingly diverse, one of which is non-physical violence through the news media. Women are often treated unfairly and even harassed their dignity in news discourse. This paper will describe the styles of two media that are quite popular in Indonesia, namely Detik.com and Media Indonesia in constructing news about the hot video of artist Gisella Anastasia. Then the discourse construction will be analyzed using Sara Mills' critical discourse analysis. Sara Mills' critical discourse analysis will analyze the discourse building holistically which includes the position of the subject-object and also the position of the writer-reader in the news. The results of the study reveal that the position of the subject and the author is dominated by men to convince the public that women are the cause of the hot video case. The tendentious narratives aimed at women by the two media in constructing discourse further exacerbate the framing inherent in women.
Keywords: Gisella Anastasia, Sara Mills Critical Discourse Analysis, Sara Mills Critical Discourse Analysis
Abstrak: Meningkatknya kekerasan pada perempuan membuat isu tentang gender akan terus menarik untuk dikaji. Bentuk kekerasan yang dilakukan pada perempuan juga semakin beragam, salah satunya kekerasan non fisik lewat media pemberitaan. Perempuan kerap diperlakukan tidak adil bahkan dilecehkan martabatnya dalam pewacanaan berita. Tulisan ini akan menguraikan gaya dua media yang cukup populer di Indonesia yaitu Detik.com dan Media Indonesia dalam mengkonstruksikan berita tentang video panas artis Gisella Anastasia. Kemudian konstruksi wacana akan dianalisa dengan menggunakan analisis wacana kritis Sara Mills. Analisis wacana kritis Sara Mills akan menganalisa bangunan wacana secara holistik yang meliputi posisi subjek-objek dan juga posisi penulis-pembaca dalam pemberitaan. Hasil penelitian mengungkapkan posisi subjek maupun penulis dikuasai oleh laki-laki untuk meyakinkan publik bahwa perempuan sebagai penyebab terjadinya kasus video panas. Narasi tendensius yang ditujukan bagi perempuan oleh kedua media dalam mengkonstruksikan wacana semakin memperburuk framing yang melekat pada perempuan.
Kata Kunci: Gisella Anastasia, Analisis Wacana Kritis Sara Mills, Critical Discourse Analysis Sara Mills
Risiko KDRT terhadap Anak sebagai Dampak Ketegangan Sosial Akibat Pandemi Covid-19
Authors: Sukmariana Indira , Wirawan Logan Gunadi , Tsabitah Hanna , Arya Freishya Manayra 
Published: January 2022

Abstract: Various drastic and sudden changes caused by the COVID-19 pandemic have an impact on economic and social implications that affect various aspects of life, including life in the family. Increased social tensions arise in line with economic imbalances and self-isolation as a result of the pandemic, so that it has the potential to create ideal conditions involving Domestic Violence (KDRT) against children by parents. This study sought to monitor this potential by using a survey-based study to determine the relationship between parental experience (n=150) with increased social tension and risky behavior patterns towards children. The results obtained will be analyzed contextually with existing research, namely regarding the factors of Domestic Violence (KDRT) against children. The results obtained indicate a relationship between social tension and risky behavior of parents towards their children.

Keywords: Pandemic, domestic violence, social tension
Abstract: Berbagai perubahan drastis dan mendadak yang diakibatkan oleh pandemi COVID-19 berdampak pada implikasi ekonomi dan sosial yang mempengaruhi beragam aspek kehidupan, termasuk kehidupan dalam keluarga. Peningkatan ketegangan sosial muncul sejalan dengan adanya ketidakseimbangan ekonomi dan isolasi diri yang merupakan dampak dari pandemi, sehingga berpotensi untuk menciptakan kondisi ideal yang melibatkan Kekerasan Dalam Rumah Tangga (KDRT) terhadap anak oleh orang tua. Penelitian ini berusaha mengawasi potensi terjadinya hal tersebut dengan menggunakan studi berbasis survei untuk menentukan hubungan antara pengalaman orang tua (n=150) dengan peningkatan ketegangan sosial dan pola perilaku beresiko terhadap anak. Hasil yang didapatkan akan dianalisis secara kontekstual dengan penelitian yang telah ada, yaitu mengenai faktor-faktor Kekerasan Dalam Rumah Tangga (KDRT) terhadap anak. Hasil temuan yang didapatkan menunjukkan adanya hubungan antara ketegangan sosial dan perilaku berisiko orang tua terhadap anak.

Kata Kunci: Pandemi, KDRT, ketegangan sosial
A statistical bias correction technique for global climate model predicted near-surface temperature in India using the generalized regression neural network
Authors: Dutta Diljit , Bhattacharjya Rajib Kumar 
Published: January 2022

Abstract
Global climate models (GCMs) developed by the numerical simulation of physical processes in the atmosphere, ocean, and land are useful tools for climate prediction studies. However, these models involve parameterizations and assumptions for the simulation of complex phenomena, which lead to random and structural errors called biases. So, the GCM outputs need to be bias-corrected with respect to observed data before applying these model outputs for future climate prediction. This study develops a statistical bias correction approach using a four-layer feedforward radial basis neural network – a generalized regression neural network (GRNN) to reduce the biases of the near-surface temperature data in the Indian mainland. The input to the network is the CNRM-CM5 model output gridded data of near-surface temperature for the period 1951–2005, and the target to the model used for bias correcting the input data is the gridded near-surface temperature developed by the Indian Meteorological Department for the same period. Results show that the trained GRNN model can improve the inherent biases of the GCM output with significant accuracy, and a good correlation is seen between the test statistics of observed and bias-corrected data for both the training and testing period. The trained GRNN model developed is then used for bias correction of CNRM-CM5 modelled projected near-surface temperature for 2006–2100 corresponding to the RCP4.5 and RCP8.5 emission scenarios. It is observed that the model can adapt well to the nature of unseen future temperature data and correct the biases of future data, assuming quasi-stationarity of future temperature data for both emission scenarios. The model captures the seasonal variation in near-surface temperature over the Indian mainland, having diverse topography appreciably, and this is evident from the bias-corrected output.
Design, Molecular Docking, Synthesis, Characterization and Biological
Activities of Novel Thiazole Derivatives
Authors: Yamsani Neeharika , Sundararajan Raja 
Published: January 2022

Aim:
The study aims to design and synthesize novel thiazole derivatives as potent antitubercular
agents with minimal side effects.

Background:
The emergence and rapid spread of multi-drug resistant infectious microbial flora embracing
a variety of bacterial as well as mycobacterium strains are causing a threat to public health worldwide.

Objective:
Owing to the importance, we designed compounds with thiazole functionality coupled with
Schiff base and thiosemicarbazide, predicted the molecular properties and antitubercular potency of designed
compounds by the in-silico method, and synthesized fifteen novel thiazole analogs, characterized
and tested in vivo antitubercular, antibacterial and antioxidant potencies.

Methods:
Molinspiration online tool was used to predict the molecular properties and molecular docking
was used to predict the antitubercular potency. FT-IR, 1H-NMR, 13C-NMR, Mass spectroscopy and bases
of elemental analysis are employed to confirm the structure of compounds. 10-Fold serial dilution method,
agar streak dilution test and DPPH radical scavenging methods are used to estimate antitubercular,
antibacterial and antioxidant potency of title analogs, respectively.

Results:
Multi-step synthesis was used to synthesize a variety of novel thiazole derivatives coupled with
Schiff base and thiosemicarbazide. Synthesized title compounds displayed a varying degree of antitubercular,
antibacterial and antioxidant activities (mild to good). The title compounds possessing deactivating
group exhibited superior activities than activating group, while unsubstituted analogs displayed intermediate
activities. In addition, para-substituted analogs showed slightly higher activity than the corresponding
meta substituted analogs.

Conclusion:
Among fifteen tested title compounds, the potent compound of this series was found to be 1-
(4-nitrobenzylidene)-4-(4-(4-methoxyphenyl)thiazol-2-yl)thiosemicarbazide (BTS14), which might be
extended as a novel class of antitubercular and antibacterial agents.
Monoclonal Antibodies and their Target Specificity Against
SARS-CoV-2 Infections: Perspectives and Challenges
Authors: Bakkari Mohammed A. , Moni Sivakumar Sivagurunathan , Sultan Muhammad Hadi , Madkhali Osama A. 
Published: January 2022

Abstract:
The world continues to be in the midst of a distressing pandemic of coronavirus disease 2019 (COVID-19) infection caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel virus with multiple antigenic systems. The virus enters via nasopharynx, oral and infects cells by the expression of the spike protein, and enters the lungs using the angiotensin-converting enzyme-2 receptor. The spectrum of specific immune responses to SARS-CoV-2 virus infection is increasingly challenging as frequent mutations have been reported and their antigen specificity varies accordingly. The development of monoclonal antibodies (mAbs) will have a more significant advantage in suppressing SARS-CoV-2 virus infectivity. Recently, mAbs have been developed to target specific neutralizing antibodies against SARS-CoV-2 infection. The use of the therapeutic index of mAbs that can elicit neutralization by binding to the viral spike protein and suppress the cytokine network is a classic therapeutic approach for a potential cure. The development of mAbs against B-cell function as well as inhibition of the cytokine network has also been a focus in recent research. Recent studies have demonstrated the efficacy of mAbs as antibody cocktail preparations against SARS-CoV-2 infection. Target specific therapeutic accomplishment with mAbs, a milestone in the modern therapeutic age, can be used to achieve a specific therapeutic strategy to suppress SARS-CoV-2 virus infection. This review focuses on the molecular aspects of the cytokine network and antibody formation to better understand the development of mAbs against SARS-CoV-2 infection.
Is the Mandibular Condyle Involved in Medication-Related Osteonecrosis of the Jaw? Audit of a Single Tertiary Referral Center and Literature Review
Authors: Lo Giudice Giorgio , Troiano Antonio , Lo Faro Carmelo , Santagata Mario , Montella Marco , D’Amato Salvatore , Tartaro Giampaolo , Colella Giuseppe 
Published: January 2022

Background:
Medication-related osteonecrosis of the jaw (MRONJ) may manifest as exposed mandible bone. Recent reviews of the incidence of MRONJ report primarily as exposed cortical bone of the mandibular body, ramus, and symphysis with no reports of condylar involvement.

Objective:
The aim of this study is to analyze the topographical incidence of MRONJ, comorbidities, demographics data, and clinical characteristics of patients diagnosed with MRONJ between 2014 and 2019 in the Maxillo-Facial Surgery Department University of Campania “Luigi Vanvitelli”, and compare these results with published reports.

Methods:
Data on 179 patients were collected for the study, including gender, age, underlying malignancy, medical history, and specific lesion location-identifying premaxilla and posterior sectors area involvement for the maxilla and symphysis, body, ramus, and condyle area for the mandible. A literature review was performed in order to compare our results with similar or higher sample sizes and find if any condylar involvement was ever reported. The research was carried out on PubMed database identifying articles from January 2003 to November 2020, where MRONJ site distribution was discussed, and data were examined to scan for condylar localization reports.

Results:
30 patients had maxillary MRONJ, 136 patients had mandibular MRONJ, and 13 patients had lesions located in both maxilla and mandible. None of the patients reported condylar involvement, neither as a single site nor as an additional localization. Literature review results were coherent to our findings showing no mention of condylar MRONJ.

Conclusion:
Results do not show reports of condylar involvement in MRONJ. Although the pathophysiology of the disease has not been fully elucidated, two possible explanations were developed: the first one based on the condyle embryogenetic origin; the second one based on the bisphosphonate and anti-resorptive medications effects on the different vascular patterns of the mandible areas.
Prevalence and Recovery of Microorganisms from Containers used for the Collection of Forensic Biological Samples
Authors: Dass Gitanjali , Sharma Vrishty , Malla Muneer Ahmad , Lukose Sally , Kori Rajesh Kumar 
Published: January 2022

Background:
Microbes play a significant role in the degradation of biological evidence collected for forensic analysis. The present study is aimed to isolate and identify the microbes present inside the empty container used for the biological evidence collection.

Methods:
Bacterial isolation from the selected containers was done by cotton swab over the inner surface of the containers. Streaking was done on the surface of the three different culture plates as a Blood agar plate, Nutrient plate and MacConkey plate. The plates were placed in an incubator shaker at 37ºC for 48 hours. The colonies grown on the surface of the media were counted on and used for further study. Various biochemical assays were performed to characterize isolated bacteria.

Results:
Staining results suggested that the presence of Gram-positive stain (Staphylococcus, Bacillus, Corynebacterium, Clostridium) and Gram negative stain (E. coli, Enterobacteriaceae, Pseudomonas, Salmonella, Shigella, Stenotrophomonas, Bdellovibrio, Acetic acid bacteria). The Catalase and Coagulase test suggested the presence of Staphylococcus aureus, S. epidermis and S. sapropyticus. Moreover, the indole test suggested the presence of Citrobacter koseri, Kebsiella oxytoca, Proteus vulgaris etc. Some of the bacteria were urea metabolizing, including Proteus spp, Helicobacter pylori, Cryptococcus spp, Corynebacterium spp.

Conclusion:
This study recommends that there should be proper maintenance of the chain of custody from the collection to analysis so that evidence properly prevents degradation or contamination in the biological evidence. Extra care is needed for the collection and packing of biological evidence from the crime scene. Moreover, the collection containers, if left wide open, lead to contamination and degradation of biological evidence.
Self-Leadership Practices of Nurse Educators at South African Nursing Education Institutions
Authors: Matahela Vhothusa Edward , Van Rensburg Gisela Hildegard 
Published: January 2022

Background:
Self-leadership has emerged as a leadership style that could be used to achieve successful performance for individuals and organisations, including higher education institutions. It is, however, not known how nurse educators perceive their self-leadership practices.

Objective:
To describe the self-leadership practices of nurse educators at nursing education institutions.

Methods:
This article reports the quantitative phase of a broader exploratory, descriptive, sequential mixed-method design study conducted with conveniently selected nurse educators (n=265) in two provinces in South Africa. Data were collected using a self-administered questionnaire.

Results:
Constructs found to be valid for self-leadership practices were autonomy-supportive environment, continuing professional development, role modelling, and shared leadership. Respondents perceived themselves to be engaged in self-leadership practices. The Cronbach alpha coefficient indicated the internal consistency of the constructs.

Conclusion:
Educational institutions should create environments that support autonomy and role modelling to facilitate the engagement of nurse educators in self-leadership practices.
The Effect of Institutional Support on the Cultural Intelligence of Nursing Students
Authors: Phanphairoj Kanjanee 
Published: January 2022

Background:Cultural intelligence is important for studying, working, and living in multicultural societies. Previous studies have indicated that training and learning support are important for improving students’ cultural intelligence. The purpose of this study was to investigate the effect of institutional support on cultural intelligence.Methods:933 nursing students in three countries, among Malaysia, the Philippines, and Thailand, answered a rating scale questionnaire. A structural equation model was used to examine the effect of institutional support on cultural intelligence.Results:Institutional support had a statistically significant effect on cultural intelligence, with an effect size of 0.57.Conclusion:For promoting cultural intelligence divided into three aspects, the first concerns the implementation of multicultural experiences in curricula; the second involves extra-curricular activities for being applied in multicultural situations; and the last regards encouraging teachers to realize the importance of culture and integrating cultural content in their teaching and in the students’ learning.