bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancement of immiscible fluid mixing using passive micromixers to increase the performance of liquid-liquid extraction
Authors: Amini Younes , Shadman Mohammad Mahdi , hassanvand Amin , Ghazanfari V. 
Published: December 2022

Abstract
This paper aims to simulate an immiscible two-phase flow in two-dimensional micro mixers numerically. The effects of various parameters, including Capillary number, phase flow rate ratio, and channel width ratio, on the generation of droplets, were studied. Also, modification of T-shaped and cross-shaped micromixers was proposed. The results reveal that equidistant tiny droplets are generated in the modified micromixers compared to ordinary geometry under the same conditions. Moreover, this study demonstrates that the multiphase flows in micro-devices are very sensitive to even small changes in the channel geometry.
Synthesis of Crystalline Carbon Nitride with Molten Salt Thermal Treatment for Efficient Photocatalytic Reduction and Removal of U(Ⅵ)
Authors: Wu Zhiwen , Wang Bo , Zhu Yean , Xue Jinming , Nie Yidan , Xie Zongbo , Le Zhanggao 
Published: December 2022

Abstract
It is critical to recover uranium from wastewater containing U(VI) and to ensure the commercial development of nuclear related energy sources. With the rapid development of photocatalytic technology, the extraction and recovery methods of uranyl ions from contaminated areas has become clearer. However, it faces several challenges, such as low charge carrier migration and lack of active sites. In order to improve the efficiency of photocatalytic reduction of uranium, the crystallized carbon nitride (CCN) catalysts at different temperatures were successfully obtained and well characterized. The effects of catalyst dosage, pH value of solution and concentration of U(Ⅵ) on the photocatalytic reactions, as well as the photoreduction mechanisms were investigated in detail. The results demonstrate that CCN can effectively remove U(Ⅵ) by photocatalytic reduction, which has a great application prospect for the treatment of uranium-containing wastewater.
Associations of Parenting Stress with Anterior Thalamic Radiations and Reuniens Nuclei in the Developing Brain
Authors: Cheong Yong Jeon , Lee Seonkyoung , Yu Jinyoung , Ro Ji Hyeong , Jung Minyoung 
Published: December 2022

Abstract
Despite the importance of child-caregiver interactions in child development, the association between parenting stress and the brain development of children remains unclear. We investigated how parenting stress relates to neural connectivity in the white matter structures and whether it has any associations with volume of thalamic subfields in 47 typically developing children (24 girls, mean age: 8.96 years old). While parents completed the Parenting Stress Index (PSI), children underwent diffusion tensor imaging (DTI) and structural magnetic resonance imaging (sMRI) scanning. The six PSI subscales reflecting child characteristics were negatively associated with the mean fractional anisotropy values of the bilateral anterior thalamic radiations (ATRs), bridging thalamus to the prefrontal cortex. Our exploratory analysis on thalamic subfields disclosed significant negative associations between the six PSI subscales and the volume of the right reuniens nuclei (MV-re) that is situated in the medial ventral thalamus and mediates interaction between the hippocampus and the prefrontal cortex. Considering a reduced white matter integrity in bilateral ATRs and smaller MV-re volume, parenting stress stemming from child-related features may reflect inefficient exchange of information via thalamocortical circuits in the developing brain. Our findings indicate the significance of interactions in child-caregiver dyads in brain development and particularly, thalamic structures.
A Hybrid Algortihm for Aadhaar Card Security Using Rsa With Rk and Gt
Authors: Lizy R.Felista Sugirtha , Raj V.Joseph 
Published: December 2022

Abstract
The protection of the underlying networking infrastructure against illegal access, misuse, or theft is known as network security. It entails establishing a secure infrastructure that allows devices, applications, users, and applications to operate safely. The primary purpose of this study is to improve the RSA algorithm's security. As a result, improvements in the Feistel (F) function integrating RSA, RK, and Game Theory's Mixed Strategy concepts are being made to improve the safety of the RSA cryptographic algorithm. The impact of the RK-GT-RSA algorithm has been analyzed using a number of performance metrics. By improving its Avalanche Effect, Speed, Throughput, and Power Consumption performance, the RK-GT-RSA algorithms are presented. The performance of the RK-GT-RSA algorithm has been improved, and experimental results have been shown.
The Role of RNA Methylation Modification Related Genes in Prognosis and Immunotherapy of Colorectal Cancer
Authors: Lin Ruoyang , Chen Renpin , Ye Lechi , Huang Zhiming , Lin Xianfan , Chen Tanzhou 
Published: December 2022

Abstract
This study aimed to analyze the effects of RNA methylation regulatory genes in prognosis and treatment of CRC. Prognostic signature associated with CRCs were constructed by differential expression analysis, Cox and LASSO analyses. ROC and Kaplan-Meier survival analyses were used to validate the reliability of the developed model. Finally, normal and cancerous tissue were collected to validate gene by qRT-PCR. A prognostic risk model based on LRPPRC and UHRF2 was constructed and relevant to the OS of CRC. Ultimately, PCR validation showed that a significant upregulation in the expression of LRPPRC and UHRF2 in cancerous tissue. A prognostic risk model based on LRPPRC and UHRF2 was successfully built, and the model could predict the immunotherapy efficacy of CRC.
An Innovative Ferroptosis-related Genes Signature for Prediction of Prognosis and Immune Microenvironment in Patients with Hepatocellular Carcinoma
Authors: Zhang Shihang , Xu Jian , Wang Jianguo , Shen Bingbing , Jiang Jianxin 
Published: December 2022

Abstract
Background: Hepatocellular carcinoma (HCC) is a lethal malignancy with high heterogeneity, which impedes prognostic prediction. Cuproptosis is an innovative copper-trigged modality of mitochondrial cell death. Ferroptosis is a unique form of programmed cell death with iron-dependent phospholipid peroxidation. The target of this study was to establish a new signature with ferroptosis-related genes conjoining cuproptosis-related genes for the prediction of prognosis and tumor immunity in patients with HCC.
Method: The expression profiles and corresponding clinical data of HCC patients were retrieved from TCGA. Pearson correlation analysis was conducted to identify the cuproptosis-related ferroptosis genes (CRFGs). A risk prognostic signature of 5-gene was constructed based on the CRFGs via the Cox regression and the least absolute shrinkage and selection operator (LASSO) method. Subsequently, the prognostic performance of the signature was evaluated by survival analysis, nomogram, Cox regression, clinicopathological characteristics correlation analysis, and the receiver operating characteristic (ROC) curve. Furthermore, the GO, KEGG pathway, GSEA, protein-protein interaction (PPI), the correlation between the signature risk score and immune cell infiltration, immune checkpoint, immune function, TMB, TIDE score, ESTIMATE score, and anticancer drug sensitivity were analyzed.
Results: The 5-CRFGs signature comprising ATG13, BAP1, ELAVL1, SLC38A1, and YY1AP1 were explored to ameliorate the prognosis prediction of HCC patients. Kaplan-Meier analysis and ROC curve revealed the high-risk group associated with a poorer prognosis compared to the low-risk group. Cox regression and stratified survival analysis demonstrated that this signature was a risk factor independent of various clinical parameters. Moreover, immune cell infiltration, immune function, immune checkpoint, increased TMB, decreased TIDE score, ESTIMATE score, and half-inhibitory concentration significantly differed between high-and low-risk subtypes, which implied that the signature had acceptable assessing potency in the clinical efficacy of chemotherapy and immunotherapy.
Conclusion: The novel cuproptosis-related ferroptosis gene signature indicated extraordinary predictive potency in prognosis and the immune microenvironment, which can provide a potentially promising therapeutic strategy for HCC patients.
Imagination Beyond National Jurisdiction - Computing and Envisioning Possible Sustainable Futures for the High Seas
Authors: Lübker Hannah Marlen , Keys Patrick W. , Merrie Andrew , Pereira Laura M. , Rocha Juan C. 
Published: December 2022

Abstract
The high seas are experiencing a stark increase in industrial activities, with resources being exploited unsustainably and shared unequally. This suggests the need for a transformation, a shift in the deeper structures of the system such as underlying paradigms and mind-sets. We created future visions by combining computational text analysis with a structured yet creative futuring approach. This process resulted in four science fiction stories, which aim to capture the complexity of the system, embrace the inherent uncertainty of the future and question current unsustainable trajectories, while emphasizing the vastness of future option space. The visions are analyzed using the concept of imaginaries, demonstrating that futuristic stories can be traced back to current realities and the scientific evidence they were based upon. We argue that engaging with alternative futures can open up transformative spaces to rethink the relationships between humans and the high seas, from which novel imaginaries can emerge.
Comparison of patients with community-acquired and hospital-acquired sepsis or septic shock: a systematic review and meta-analysis
Authors: Li Yuting , Wang Youquan , Guo Jianxing , Li Hongxiang , Yang Hongmei , Zhang Dong 
Published: December 2022

Abstract
Background
Mortality and other clinical outcomes between community-acquired and hospital-acquired patients with sepsis or septic shock have been documented inconsistently and are controversial. A systematic review and meta-analysis was performed to compare the clinical outcomes of community-acquired and hospital-acquired sepsis or septic shock.
Methods
We searched the PubMed, Embase databases and Cochrane Library for studies from inception to the 1st of Oct. 2022. We included studies involving patients with sepsis or septic shock. All authors reported our primary outcome of all-cause mortality and clearly comparing community-acquired versus hospital-acquired patients with clinically relevant secondary outcomes (ICU length of stay, hospital length of stay, mechanical ventilation requirements, renal replacement requirements, days on vasopressor and cost of hospitalization). Results were expressed as odds ratio (OR) and mean difference (MD) with accompanying 95% confidence interval (CI).
Results
Thirteen studies including 1175830 patients were included. The primary outcome of this meta-analysis showed that the all-cause mortality of hospital-acquired group was higher than that of the community-acquired group(OR = 0.43; 95% CI, 0.42 to 0.43; P < 0.00001; Chi2 = 262.95; I2 = 95%). Secondary outcomes demonstrated that the ICU length of stay of hospital-acquired group was longer than that of the community-acquired group(MD=-4.38;95% CI, -4.43 to -4.32; P < 0.00001;Chi2 = 2678.16; I2 = 100%), the hospital length of stay of hospital-acquired group was longer than that of the community-acquired group (MD=-12.36;95% CI, -12.44 to -12.27; P < 0.00001;Chi2 = 539.65; I2 = 98%), the mechanical ventilation requirements of hospital-acquired group was more than that of the community-acquired group (OR = 0.39; 95% CI, 0.32 to 0.46; P < 0.00001; Chi2 = 18.54; I2 = 84%), the days on vasopressor of hospital-acquired group was longer than that of the community-acquired group (MD=-1.71;95% CI, -1.78 to -164; P < 0.00001;Chi2 = 289.53; I2 = 100%), the cost of hospitalization of hospital-acquired group was more than that of the community-acquired group (MD=-34064.29; 95% CI, -34327.71 to -33800.87; P < 0.00001;Chi2 = 63.96; I2 = 98%). There was no statistically significant difference in the renal replacement requirements between two groups(OR = 0.75; 95% CI, 0.52 to 1.09; P = 0.13; Chi2 = 0.29; I2 = 0%).
Conclusions
The proportion of hospital-acquired sepsis or septic shock is about 12.9%. Compared with community-acquired sepsis or septic shock patients, hospital-acquired ones had higher mortality and other worse clinical outcomes, including longer ICU and hospital length of stay, more requirements of mechanical ventilation and renal replacement, longer vasopressor days and more cost of hospitalization.
ProS/Mer alleviates sepsis-induced neuromuscular dysfunction by inhibiting TLR4/MyD88/NF-κB signals
Authors: Xie Fei , Sun Jiaxin , Zhang Hongwei , Zhou Shukui 
Published: December 2022

Abstract
Background
Sepsis remains a significant cause of morbidity and mortality worldwide, with systemic inflammation and behavioral impairment. Microglia are well-known critical regulators of neuroinflammation, which feature in multiple neurodegenerative disorders. These cells become “activated” through stimulation of toll-like receptors (TLRs), resulting in changes in morphology and production and release of cytokines. Myeloid-epithelial-reproductive tyrosine kinase (Mer), a member of the Tyro-Axl-Mer (TAM) family of receptor tyrosine kinases, regulates multiple features of microglial/macrophage physiology. The present study examined the roles of the related TAM receptors, Mer, and its ligand, Protein S (ProS), in regulating neuroinflammation and neuromuscular function following sepsis.
Methods
The sepsis was established by cecal ligation and puncture (CLP) in wildtype (WT) and Mer−/− rats, and recombinant protein S (ProS) or normal saline (NS) was intrathecally injected for intervention. The muscle weight, neuromuscular function, Nissl staining, immunofluorescence, ELISA, and Western blot were performed.
Results
Knockout of Mer showed significantly decreased muscle weight and neuromuscular function at day 4 post-CLP, as well as increased inflammatory cytokines, activated microglia/macrophage, and TLR4/MyD88/NF-κB signal pathway in the spinal cord. The administration of ProS activated the signal transducer and activator of transcription 1 (STAT1)/suppressor of cytokine signaling 1/3 (SOCS1/3) pathway and inhibited the TLR4/MyD88/NF-κB signal pathway, which alleviated the neuromuscular dysfunction after CLP.
Conclusion
ProS/Mer alleviates muscle atrophy and neuromuscular dysfunction in the sepsis model by activating the STAT1/SOCS signaling pathway and inhibiting the TLR4/MyD88/NF-κB signaling pathway.
Bibliometric analysis of scientific publications of surgical procedures for papillary thyroid cancer
Authors: Li Wei , Zhao Dan , Zhang Xiaomei 
Published: December 2022

Abstract
Background
Papillary thyroid cancer (PTC) is the most common pathological strain of thyroid cancer, and thyroidectomy is the most traditional and currently dominant treatment for PTC. However, the large number of publications on surgical procedures for PTC is not well summarized. This study aims to condense information from scientific papers on surgical procedures for PTC published over the past three decades, quantify the research progress in this field, respond to research hotspots, and reveal potential future research directions.
Methods
The scientific publications assessed in this study were retrieved from the Science Citation Index—Expanded (SCI-E) database, having been published between 1990–2021. Annual outputs, high-yield journals, countries, institutions, authors, and their citation times were summarized. In addition, bibliometric analysis was performed on keyword co-occurrence, burst citations, and citation networks. The relationships between citations were computed and visualized using the CiteSpace_5.7.R5W and VOSviewer_1.6.16 visualization software programs.
Results
A total of 442 articles on "surgical procedures for PTC" were indexed in SCI-E during the past 30 years, covering five categories, namely, endocrinology and metabolism; surgery; oncology; otorhinolaryngology; and radiology, nuclear medicine, and medical imaging. The United States, Italy, and South Korea showed dominance in terms of publication output, h-index, and total citations. Thyroid was the top publisher of relevant papers, and the most-cited article was “2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer.” The keywords that appeared most frequently were “cancer”, “carcinoma”, “management”, “surgery”, “papillary”, and “nodules”. Popular research topics were "association guidelines,” "extent,” "meta-analysis,” "lymph node metastasis, " and "outcome." In addition, new surgical methods, including intraoperative nerve monitoring and robot-assisted surgery, have been advanced in recent years and may have a good future in the field of PTC surgery.
Conclusions
This study provides a comprehensive analysis of research in the field of surgical procedures for PTC. How to effectively screen patients for immediate surgery and develop uniform criteria for recommending surgery for patients with progressive lesions may be a focus of research in the coming years.
Challenges in Conducting Population-based Seroepidemiology Survey of Covid-19 in Lagos State, Nigeria
Authors: Ojogbede Adewale Kayode , Bamidele Tajudeen , Aina Oluwagbemiga , Raheem Toyosi , Okwuraiwe Azuka , Amoo Olufemi , Osuolale Kazeem Adewale , Oladele David , Salako Abideen , Ige Fehintola , Musa Adesola Zaidat , Idigbe Ifeoma , Anwoju Fatimoh , Baruwa Sikiru , Abdur-Razzak Hussein , Adebayo Bisola , Wright Kikelomo , Ohihoin Aigbe , Ezechi Oliver , Audu Rosemary 
Published: December 2022

Abstract
Population-based study is known to be a very essential type of study during and after a pandemic or epidemics, as it provides important information on the incidence, prevalence and risk factors of the disease in question. There has been limited information about challenges faced in conducting such surveys in Nigeria. In this paper, we would share our experience, and describe the challenges faced in conducting population-based seroepidemiological study of COVID – 19 in Lagos, Nigeria. Some challenges were peculiar to specific Local Government Areas (LGAs) while others were general. The challenges include general misconception of community members about health research, difficulties in mapping houses, planning for data collection, standardising data collection, working in hard-to-reach community when resources were limited as well as difficulty in collection of blood, oral and naso-oropharyngeal swabs. Ways of overcoming these problems, lessons learnt, and recommendations are hereby discussed.
Impact of cardiac shock wave therapy on the dynamics of biomarkers: results of proteomic analysis
Authors: Burneikaitė Greta , Jasiūnas Eugenijus , Shkolnik Evgeny , Zuozienė Gitana , Misonis Nerijus , Petrauskienė Birutė , Kazėnaitė Edita , Laucevičius Aleksandras , Smih Fatima , Rouet Philippe , Čelutkienė Jelena 
Published: December 2022

Abstract
Background: Cardiac shock-wave therapy (CSWT) is a non-invasive treatment based on low-frequency ultrasound waves that stimulate angiogenesis. Current data on the effects of revascularization procedures on angiogenesis biomarkers are limited.
In this study, we aimed to characterize the serum protein profiles of patients with coronary artery disease after CSWT treatment in relation to changes in exercise and imaging parameters.
Methods: The study population included 10 patients from a prospective, randomized, triple-blind, sham-procedure controlled study (NCT02339454), who received CSWT and had demonstrated improvement in myocardial perfusion and/or contractility at 6 months follow-up
The blood samples were collected at baseline, after the last treatment procedure (9th treatment week), at 6-month follow-up and stored at −80°C until analysis. The cardiovascular-related proteins (n=92) were measured using the Olink Proseek Multiplex Cardiovascular III panel (Olink, Uppsala, Sweden).
Results: The median age was 65.5 years, and 7 patients were males. A total of 20 biomarkers showed significant changes from baseline to 9th week and 6 months follow-up (p<0.05).
We identified 28 proteins that showed clear association with an increase in exercise tolerance and improvement in myocardial contractility or perfusion after CSWT. Using a volcano plot and results from the paired Mann-Whitney U test at confidence level of 0.95, we identified 3 proteins (PON3, TR-AP, CD163) with elevated values corresponding to increase in exercise duration (p<0.05) and 2 proteins (CPA1, COL1A1) related to improved myocardial contractility (p<0.05).
A pathway analysis including 28 proteins suggested that these biomarkers were related to immune and inflammatory response, cell adhesion, tissue remodeling, proteolysis and catabolic processes.
Conclusions: This study demonstrates the association of an increase in protein levels with an improvement in exercise duration and contractile function. Proteomic analysis suggests that CSWT exerts biological effects including immune and inflammation response, cell adhesion and tissue remodeling, all of which may mediate angiogenesis.
Trial registration: Clinicaltrials.gov (NCT02339454).
Standardized Equipment Management Procedures and Fleet Management of Department of Public Works and Highways Region Iv-a
Authors: Naelgas Mary Anne 
Published: December 2022

Abstract
The study determined the implementation of the standardized equipment management procedures (SEMP) and fleet management of the Department of Public Works and Highways (DPWH) Region IV-A for a basis of a proposed Equipment Services Section (ESS). It aimed to answer the level of perceptions of the respondents in the implementation of SEMP in terms of Equipment Administration (EA), Preventive Maintenance (PM), and Repair Process (RP), determine the problems encountered in fleet management, and if there are significant differences between the perceptions of the respondents in the implementation of SEMP and in the problems encountered in fleet management. The researcher adopted the descriptive survey method. The data gathered were treated using mean, standard deviation, analysis of variance, and posteriori test. The findings revealed that the null hypothesis which stated that there is no significant difference in the level of implementation of SEMP in DPWH Region IV-A in terms of equipment administration and repair process and the problems encountered in fleet management is accepted. However, the null hypothesis which states that there is no significant difference in the implementation of SEMP in terms of preventive maintenance is rejected.