bluuebunny/crossref_metadata_2025_split huggingface dataset:
Secrecy satellite‐terrestrial downlink transmissions against randomly located eavesdroppers
Authors: Wu Haowei , Huang Fengjiao , Xiao Pei , Fang Ke , Ou Jinglan 
Published: November 2022

AbstractThe satellite‐terrestrial downlink transmissions with larger coverage areas face more severe security challenges than terrestrial cellular communications due to the limitation of the satellite's power and the complexity of the channel. In this paper, the system model consists of one satellite, one legitimate user and multiple randomly distributed eavesdroppers while taking into account practical hardware impairments (HIs) at all transceivers involved. The Shadowed‐Rician fading model is adopted since it is a perfect fit for the satellite‐terrestrial channel. Besides, the full‐duplex (FD) operation is introduced in the destination where the receiver acquires the information signal and simultaneously emits the artificial noise (AN) to interfere with the nearby eavesdroppers. The maximal ratio combination scheme is applied to the destination to improve security. To facilitate evaluation of the effect of various parameters on the security performance, the closed‐form expressions of secrecy outage probability and ergodic secrecy capacity for the system are derived under the stochastic geometry framework. Finally, the simulation results show that the AN plays a pivotal role in improving the security performance, while the HIs can greatly deteriorate the performance, especially in the high transmit power regime. In addition, compared with the traditional half‐duplex receiver, the FD receiver have better security performance and can significantly alleviate the performance deterioration caused by HIs.
Practical challenges of continuous real‐time functional magnetic resonance imaging neurofeedback with multiband accelerated echo‐planar imaging and short repetition times
Authors: Renz Malika P. , Zidda Francesca , Andoh Jamila , Prager Marcel , Sack Markus , Becker Robert , Ruf Matthias , Schmitgen Mike M. , Wolf Robert C. , Meyer‐Lindenberg Andreas , Tost Heike 
Published: November 2022

AbstractContinuous real‐time functional magnetic resonance imaging (fMRI) neurofeedback is gaining increasing scientific attention in clinical neuroscience and may benefit from the short repetition times of modern multiband echoplanar imaging sequences. However, minimizing feedback delay can result in technical challenges. Here, we report a technical problem we experienced during continuous fMRI neurofeedback with multiband echoplanar imaging and short repetition times. We identify the possible origins of this problem, describe our current interim solution and provide openly available workflows and code to other researchers in case they wish to use a similar approach.
The impact of the COVID‐19 pandemic and related policy responses on non‐COVID‐19 healthcare utilization in China
Authors: Huang Feng , Liu Hong 
Published: November 2022

AbstractWe investigate the impact of the COVID‐19 pandemic and related policy responses on non‐COVID‐19 healthcare utilization (i.e., different types of outpatient care) up to October 2020 in China. Using an administrative database from a large prefecture‐level city, we find that both direct exposure to the COVID‐19 pandemic and the strict containment policy responses led to reductions in outpatient care utilization. The largest decline during the lockdown was observed in preventive care visits, which nevertheless recovered to pre‐pandemic levels 2 months after the lockdown. The disruptions in prenatal care visits could not be offset by the recovery later on. Chronic care and emergency department visits had not returned to pre‐pandemic levels as of October 2020, which may be driven by extended days' supply of prescription medication, increased use of telemedicine, and improved health‐protective behaviors. In the reopening period, there were increases in visits for mental and sleep disorders, especially among children, and for medical abortion. Among health facilities at all levels, primary care facilities saw the least reductions in total outpatient visits. Our results emphasize the need for strategies to ensure access to urgent or essential care services when managing the current epidemiologic transition and future crises.
Stretchable magnesium–air battery based on dual ions conducting hydrogel for intelligent biomedical applications
Authors: Huang Xingcan , Liu Yiming , Park Wooyoung , Zhao Zhao , Li Jiyu , Lim Chee Kent , Wong Tsz Hung , Yiu Chun Ki , Gao Yuyu , Zhou Jingkun , Li Hu , Zhao Ling , Li Jian , Zhang Binbin , Huang Ya , Shi Rui , Li Dengfeng , Mo Jiaying , Wang Jinpei , Zhang Chao , Li Yuhang , Wang Zuankai , Yu Xinge 
Published: November 2022

AbstractFlexible and bio‐integrated electronics have attracted great attention due to their enormous contributions to personalized medical devices. Power sources, serving as one of the most important components, have been suffering from many problems, including deficient biocompatibility, poor stretchability, and unstable electrical outputs under deformed conditions, which limits the practical applications in flexible and bio‐integrated electronics. Here, we reported a fully stretchable magnesium (Mg)–air battery based on dual‐ions‐conducting hydrogels (SDICH). The high‐performance battery enables long‐term operation with lighting 120 lighting emitting diodes (LEDs) for over 5 h. Benefiting from the advanced materials and mechanical designs, the battery exhibits stability electrical outputs under stretching, which allows to operate ordinarily under various mechanical deformations without performance decay. Furthermore, the great biocompatibility of the battery offers great opportunity for biomedical applications, which is demonstrated by a self‐adaption wound dressing system. The in vitro and in vivo results prove that the self‐adaption wound dressing can effectively prevent wound inflammation and promote wound healing. By exploiting thermal feedback mechanics, the system can adjust antibiotic release rate and dosage spontaneously according to the real‐time wound conditions. The proposed fully stretchable Mg–air battery and self‐adaption wound dressing display great potential in skin‐integrated electronics and personalized medicine.image
Rebuilding from the vacuum: A qualitative study of people with a recent history of incarceration
Authors: Fachilla Frances E. 
Published: November 2022

AbstractThirty‐four adults recently released from incarceration and living in transitional homes were interviewed in this qualitative study. An open‐ended approach to interviewing was used to allow participants’ main concerns to emerge. Participants were primarily focused on rebuilding relationships to achieve stability post‐incarceration. Participants who rebuilt stable relationships were able to work on internal goals (e.g., sobriety). Participants who did not rebuild stable relationships returned to existing social networks of unstable connections characterized by drug addiction, abuse, or criminal activity.
Application of compression optical coherence elastography for characterization of human pericardium: A pilot study
Authors: Zaitsev Vladimir Y. , Sovetsky Alexander A. , Matveyev Alexander L. , Matveev Lev A. , Shabanov Dmitry , Salamatova Victoria Y. , Karavaikin Pavel A. , Vassilevski Yuri V. 
Published: November 2022

AbstractThe recent impressive progress in Compression Optical Coherence Elastography (C‐OCE) demonstrated diverse biomedical applications, comprising ophthalmology, oncology, etc. High resolution of C‐OCE enables spatially resolved characterization of elasticity of rather thin (thickness < 1 mm) samples, which previously was impossible. Besides Young's modulus, C‐OCE enables obtaining of nonlinear stress–strain dependences for various tissues. Here, we report the first application of C‐OCE to nondestructively characterize biomechanics of human pericardium, for which data of conventional tensile tests are very limited and controversial. C‐OCE revealed pronounced differences among differently prepared pericardium samples. Ample understanding of the influence of chemo‐mechanical treatment on pericardium biomechanics is very important because of rapidly growing usage of own patients' pericardium for replacement of aortic valve leaflets in cardio‐surgery. The figure demonstrates differences in the tangent Young's modulus after glutaraldehyde‐induced cross‐linking for two pericardium samples. One sample was over‐stretched during the preparation, which caused some damage to the tissue.
Influence of the complete basis set approximation, tight weighted‐core, and diffuse functions on the DLPNO‐CCSD(T1) atomization energies of neutral H,C,O‐compounds
Authors: Minenkov Yury , Cavallo Luigi , Peterson Kirk A. 
Published: November 2022

AbstractThe impact of complete basis set extrapolation schemes (CBS), diffuse functions, and tight weighted‐core functions on enthalpies of formation predicted via the DLPNO‐CCSD(T1) reduced Feller‐Peterson‐Dixon approach has been examined for neutral H,C,O‐compounds. All tested three‐point (TZ/QZ/5Z) extrapolation schemes result in mean unsigned deviation (MUD) below 2 kJ mol−1 relative to the experiment. The two‐point QZ/5Z and TZ/QZ CBS extrapolation schemes are inferior to their inverse power counterpart () by 1.3 and 4.3 kJ mol−1. The CBS extrapolated frozen core atomization energies are insensitive (within 1 kJ mol−1) to augmentation of the basis set with tight weighted core functions. The core‐valence correlation effects converge already at triple‐ζ, although double‐ζ/triple‐ζ CBS extrapolation performs better and is recommended. The effect of diffuse function augmentation converges slowly, and cannot be reproduced with double‐ ζ or triple‐ ζ calculations as these are plagued with basis set superposition and incompleteness errors.
Frailty is characterized by biomarker patterns reflecting inflammation or muscle catabolism in multi‐morbid patients
Authors: Kochlik Bastian , Franz Kristina , Henning Thorsten , Weber Daniela , Wernitz Andreas , Herpich Catrin , Jannasch Franziska , Aykaç Volkan , Müller‐Werdan Ursula , Schulze Matthias B. , Grune Tilman , Norman Kristina 
Published: November 2022

AbstractBackgroundFrailty development is partly dependent on multiple factors like low levels of nutrients and high levels of oxidative stress (OS) and inflammation potentially leading to a muscle‐catabolic state. Measures of specific biomarker patterns including nutrients, OS and inflammatory biomarkers as well as muscle related biomarkers like 3‐methylhistidine (3MH) may improve evaluation of mechanisms and the complex networks leading to frailty.MethodsIn 220 multi‐morbid patients (≥ 60 years), classified as non‐frail (n = 104) and frail (n = 116) according to Fried's frailty criteria, we measured serum concentrations of fat‐soluble micronutrients, amino acids (AA), OS, interleukins (IL) 6 and 10, 3MH (biomarker for muscle protein turnover) and serum spectra of fatty acids (FA). We evaluated biomarker patterns by principal component analysis (PCA) and their cross‐sectional associations with frailty by multivariate logistic regression analysis.ResultsTwo biomarker patterns [principal components (PC)] were identified by PCA. PC1 was characterized by high positive factor loadings (FL) of carotenoids, anti‐inflammatory FA and vitamin D3 together with high negative FL of pro‐inflammatory FA, IL6 and IL6/IL10, reflecting an inflammation‐related pattern. PC2 was characterized by high positive FL of AA together with high negative FL of 3MH‐based biomarkers, reflecting a muscle‐related pattern. Frail patients had significantly lower factor scores than non‐frail patients for both PC1 [median: −0.27 (interquartile range: 1.15) vs. 0.27 (1.23); P = 0.001] and PC2 [median: −0.15 (interquartile range: 1.13) vs. 0.21 (1.38); P = 0.002]. Patients with higher PC1 or PC2 factor scores were less likely to be frail [odds ratio (OR): 0.62, 95% CI: 0.46–0.83, P = 0.001 for PC1; OR: 0.64, 95% CI: 0.48–0.86, P = 0.003 for PC2] compared with patients with lower PC1 or PC2 factor scores. This indicates that increasing levels of anti‐inflammatory biomarkers and increasing levels of muscle‐anabolic biomarkers are associated with a reduced likelihood (38% and 36%, respectively) for frailty. Significant associations remained after adjusting the regression models for potential confounders.ConclusionsWe conclude that two specific patterns reflecting either inflammation‐related or muscle‐related biomarkers are both significantly associated with frailty among multi‐morbid patients and that these specific biomarker patterns are more informative than single biomarker analyses considering frailty identification.
Trajectories of physical and mental functioning over 25 years before onset of frailty: results from the Whitehall II cohort study
Authors: Landré Benjamin , Ben Hassen Céline , Kivimaki Mika , Bloomberg Mikaela , Dugravot Aline , Schniztler Alexis , Sabia Séverine , Singh‐Manoux Archana 
Published: November 2022

AbstractBackgroundResearch on frailty, a major contributor to heterogeneity in health, is undertaken on older adults although the processes leading to frailty are likely to begin earlier in the life course. Using repeat data spanning 25 years, we examined changes in physical and mental functioning before the onset of frailty, defined using Fried's frailty phenotype (FFP).MethodsFunctioning was measured using the Short‐Form 36 General Health Survey (SF‐36) on nine occasions from 1991 (age range 40–63 years) to 2015 (age range 63–85 years). The poorest of four FFP scores from 2002, 2007, 2012 and 2015 was used to classify participants as frail, pre‐frail, or robust. We used linear mixed models with a backward timescale such that time 0 was the person‐specific date of frailty classification for frail and pre‐frail participants and the end of follow‐up for robust participants. Analyses adjusted for socio‐demographic factors, health behaviours, body mass index and multi‐morbidity status were used to compare SF‐36 physical (PCS) and mental (MCS) component summary scores over 25 years before time 0 as a function of FFP classification, with estimates extracted at time 0, −5, −10, −15, −20 and −25 years. We also used illness–death models to examine the prospective association between SF‐36 component summary scores at age 50 and incident FFP‐defined frailty.ResultsAmong 7044 participants of the Whitehall II cohort study included in the analysis [29% female, mean age 49.7 (SD = 6.0) at baseline in 1991], 2055 (29%) participants remained robust, and 4476 (64%) became pre‐frail and 513 (7%) frail during follow‐up. Frail compared with robust participants had lower SF‐36 scores at t = −25 before onset of frailty with a difference of 3.4 [95% confidence interval (CI) 1.6, 5.1] in PCS and 1.8 (−0.2, 3.8) in MCS. At t = 0, the differences increased to 11.5 (10.5, 12.5) and 9.1 (8.0, 10.2), respectively. The differences in SF‐36 between the robust and pre‐frail groups, although smaller [at t = 0, 1.7 (1.2, 2.2) in PCS and 4.0 (3.4, 4.5) in MCS], were already observed 20 and 25 years, respectively, before the onset of pre‐frailty. Prospective analyses showed that at age 50, scores in the bottom quartiles of PCS [hazard ratio (HR) compared with the top quartile = 2.39, 95% CI 1.85, 3.07] and MCS [HR = 1.49 (1.15, 1.93)] were associated with a higher risk of FFP‐defined frailty at older ages.ConclusionsDifferences in trajectories of physical and mental functioning in individuals who developed physical frailty at older ages were observable 25 years before onset of FFP‐defined frailty. These findings highlight the need for a life course approach in efforts to prevent frailty.
Toward a better modulus at shallow indentations—Enhanced tip and sample characterization for quantitative atomic force microscopy
Authors: Owen David S. 
Published: November 2022

AbstractApproximations of the geometry of indenting probes, particularly when using shallow indentations on soft materials, can lead to the erroneous reporting of mechanical data in atomic force microscopy (AFM). Scanning electron microscopy (SEM) identified a marked change in geometry toward the tip apex where the conical probe assumes a near linear flat‐punch geometry. Polydimethylsiloxane (PDMS) is a ubiquitous elastomer within the materials and biological sciences. Its elastic modulus is widely characterized but the data are dispersed and can display orders of magnitude disparity. Herein, we compare the moduli gathered from a range of analytical techniques and relate these to the molecular architecture identified with AFM. We present a simple method that considers sub‐100 nm indentations of PDMS using the Hertz and Sneddon contact mechanics models, and how this could be used to improve the output of shallow indentations on similarly soft materials, such as polymers or cells.
Comparison of reconstruction methods used during liver transplantation in case of a graft with replaced or accessory right hepatic artery: A retrospective study
Authors: Wouters Dune , Blondeau Marc , Bos Isabel , Camus Christophe , Jezequel Caroline , Bardou‐Jacquet Edouard , van der Plas Willemijn S. , Nieuwenhuis Lianne M. , de Meijer Vincent E. , Porte Robert J. , Rayar Michel 
Published: November 2022

AbstractVariations in graft arterial anatomy can increase the risk of postoperative hepatic arterial thrombosis (HAT), especially in presence of a replaced or accessory right hepatic artery (RHA). We retrospectively analyzed 223 cases of liver transplantations with the presence of an RHA on the graft. Patient outcomes were compared according to the four different reconstruction methods used: (i) the re‐implantation of the RHA into the splenic or gastroduodenal artery (n = 106); (ii) the interposition of the superior mesenteric artery (SMA) (n = 83); (iii) dual anastomosis (n = 24); (iv) use of an aortic patch including the origins of both the SMA and the coeliac trunk (n = 10). A competing risk analysis and Inverse Probability Weighting (IPW) were used. We found that the interposition of the SMA method was associated with a significantly lower incidence of HAT, at 4.8% compared to the re‐implantation method at 17.9%, dual anastomosis at 12.5%, and aortic patch at 20%, p = .03. In the competing risk analysis with IPW, the only risk factor for RHA thrombosis was the type of reconstruction. Taking the SMA interposition group as the reference, the sub‐hazard ratio (sHR) was 5.05 (CI 95 [1.72; 14.78], p < .01) for the re‐implantation group, sHR = 2.37 (CI 95 [0.51; 11.09], p = .27) for the dual anastomosis group and sHR = 2.24 (CI 95 [0.35; 14.33], p = .40) for the aortic patch group. There were no differences for intraoperative transfusion, hospitalization duration (p = .37) or incidence of severe complications (p = .1). The long‐term graft (p = .69) and patient (p = .52) survival was not different. In conclusion, the SMA interposition method was associated with a lower incidence of RHA thrombosis.
Isolated neurological presentations of mevalonate kinase deficiency
Authors: Hoytema van Konijnenburg Eva M. M. , Oussoren Esmeralda , Frenkel Joost , van Hasselt Peter M. 
Published: November 2022

AbstractMevalonate kinase (MK) deficiency is a rare autosomal recessive metabolic disorder caused by pathogenic variants in the MVK gene with a broad phenotypic spectrum including autoinflammation, developmental delay and ataxia. Typically, neurological symptoms are considered to be part of the severe end of the phenotypical spectrum and are reported to be in addition to the autoinflammatory symptoms. Here, we describe a patient with MK deficiency with severe neurological symptoms but without autoinflammation and we found several similar patients in the literature. Possibly, the non‐inflammatory phenotype is related to a specific genotype: the MVK p.(His20Pro)/p.(Ala334Thr) variant. There is probably an underdetection of the neurological MK deficient phenotype without inflammatory symptoms as clinicians may not test for MK deficiency when patients present with only neurological symptoms. In conclusion, although rare, neurological symptoms without hyperinflammation might be more common than expected in MK deficiency. It seems relevant to consider MK deficiency in patients with psychomotor delay and ataxia, even if there are no inflammatory symptoms.
The “vaccine” hubbub: Viral load comparisons of SARS‐CoV‐2 Delta and Omicron variants against different vaccine–booster vaccine combinations
Authors: Ergoren Mahmut C. , Akan Gokce , Volkan Ender , Kandemis Emine , Evren Emine U. , Evren Hakan , Volkan Eliz , Tuncel Gulten , Suer Kaya , Sanlidag Tamer 
Published: November 2022

AbstractThere is a significant body of evidence showing that efficient vaccination schemes against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is helping control the coronavirus disease 2019 (COVID‐19) pandemic. However, this goal cannot be achieved without real world data highlighting the impact of vaccines against viral spread. In this study, we have aimed at differentially investigating the impact of COVID‐19 vaccines (CoronaVac, Pfizer/BioNTech, Astra/Zeneca Oxford, Janssen) used in North Cyprus in limiting the viral load of Delta and Omicron variants of SARS‐COV‐2. We have utilized real‐time quantitative polymerase chain reaction cycle threshold values (Ct values) as a proxy of viral load of the two SARS‐CoV‐2 variants. Our results indicate that the administration of at least two doses of the messenger RNA‐based Pfizer/BioNTech vaccine leads to the lowest viral load (highest Ct values) obtained for both Omicron and Delta variants. Interestingly, regardless of the vaccine type used, our study revealed that Delta variant produced significantly higher viral loads (lower Ct values) compared with the Omicron variant, where the latter was more commonly associated with younger patients. Viral spread is a crucial factor that can help determine the future of the pandemic. Thus, prioritizing vaccines that will play a role in not only preventing severe disease but also in limiting viral load and spread may contribute to infection control strategies.
Significance of barrier membrane on the reconstructive therapy of peri‐implantitis: A randomized controlled trial
Authors: Monje Alberto , Pons Ramón , Vilarrasa Javi , Nart José , Wang Hom‐Lay 
Published: November 2022

AbstractBackgroundThe objective of this trial was to investigate the clinical and radiographic significance of using a mixture of mineralized and demineralized allografts in combination (M) or not (NM) with a resorbable cross‐linked barrier membrane in the reconstructive therapy of peri‐implantitis defects.MethodsA two‐arm randomized clinical trial was performed in patients diagnosed with peri‐implantitis that exhibited contained defects. Clinical parameters were recorded at baseline (T0), 6 months (T1), and 12 months (T2). Radiographic parameters were recorded at T0 and T2. A composite criterion for disease resolution was defined a priori. A generalized linear model of repeated measures with generalized estimation equation statistical methods was used.ResultsOverall, 33 patients (nimplants = 48) completed the study. At T2, mean disease resolution was 77.1%. The use of a barrier membrane did not enhance the probability of disease resolution at T2 (odds ratio [OR] = 1.55, p = 0.737). Conversely, the odds of disease resolution were statistically associated with the modified plaque index recorded at T0 (OR = 0.13, p = 0.006) and keratinized mucosa width (OR = 2.10, p = 0.035). Moreover, women exhibited greater odds to show disease resolution (OR = 5.56, p = 0.02).ConclusionReconstructive therapy by means of a mixture of mineralized and demineralized allografts is effective in clinically resolving peri‐implantitis and in gaining radiographic marginal bone level. The addition of a barrier membrane to reconstructive therapy of peri‐implantitis does not seem to enhance the outcomes of contained bone defects (NCT05282667).