bluuebunny/crossref_metadata_2025_split huggingface dataset:
Succinate Dehydrogenase loss causes cascading metabolic effects that impair pyrimidine biosynthesis
Authors: Hart Madeleine L. , Davidsen Kristian , Danquah Serwah , Zheng Eric , Sokolov David , Sullivan Lucas B. 
Published: February 2025

AbstractImpaired availability of the amino acid aspartate can be a metabolic constraint of cell proliferation in diverse biological contexts. However, the kinetics of aspartate depletion, and its ramifications on downstream metabolism and cell proliferation, remain poorly understood. Here, we deploy the aspartate biosensor jAspSnFR3 with live cell imaging to resolve temporal relationships between aspartate and cell proliferation from genetic, pharmacological, and nutritional manipulations. In cells with impaired aspartate acquisition from mitochondrial complex I inhibition or constrained uptake in aspartate auxotrophs, we find that the proliferation defects lag changes in aspartate levels and only manifest once aspartate levels fall below a critical threshold, supporting the functional link between aspartate levels and cell proliferation in these contexts. In another context of aspartate synthesis inhibition, impairing succinate dehydrogenase (SDH), we find a more complex metabolic interaction, with initial aspartate depletion followed by a rebound of aspartate levels over time. We find that this aspartate rebound effect results from SDH inhibition disproportionately impairing pyrimidine synthesis by inhibiting aspartate transcarbamoylase (ATCase) through the dual effect of diminishing aspartate substrate availability while accumulating succinate, which functions as a competitive inhibitor of aspartate utilization. Finally, we uncover that the nucleotide imbalance from SDH inhibition causes replication stress and introduces a vulnerability to ATR kinase inhibition. Altogether, these findings identify a mechanistic role for succinate in modulating nucleotide synthesis and demonstrate how cascading metabolic interactions can unfold to impact cell function.
The impact of brand perception of “standards + certification” regional quality brands on consumer loyalty – the case of “Zhejiang manufacturing”
Authors: Kong Xinyi , Zhang Yueyi , Lu Chenyuan , Hu Jing 
Published: February 2025

PurposeSince the “Standards + Certification” regional quality brand initiative has become a key component of China’s efforts to promote a quality-driven economy, this paper aims to examine the effect of perception, trust and satisfaction toward the regional quality brand on consumer loyalty.Design/methodology/approachData were collected from 401 consumers who have bought “Zhejiang Manufacturing” regional quality brand products. The structural equation modeling (SEM) technique was applied to assess the relationship of the research model.FindingsThe results show that brand perception, trust and satisfaction toward regional quality brands all significantly positively impact both consumer behavioral and attitudinal loyalty. Further, the results confirmed that brand trust and satisfaction fully mediate the relationship between brand perception and behavioral loyalty and partially mediate the relationship between brand perception and attitudinal loyalty.Originality/valueThis study presents a conceptual model on the impact of perception toward regional quality brands on consumer loyalty in a field where little research has been done. It offers a consumer-focused analysis that advances the theoretical and empirical knowledge of regional quality brands.
WITHOUT by Ashaya: an eco-conscious start-up turning trash into treasure
Authors: Anand Leenu , Shroff Arvind 
Published: February 2025

Learning outcomes
The case study aims to achieve the following learning objectives post discussion by the students: evaluate Social Entrepreneurship Quotient of Anish Malpani, founder of WITHOUT; understand Sustainable Development Goals to which the start-up aims to contribute; apply the framework of SWOT analysis to the social start-up; and analyze triple bottom line and triple top line concepts to identify approach of WITHOUT.

Case overview/synopsis
Malpani’s eco-conscious start-up named “Ashaya Recyclers Pvt. Ltd.” is the first of its kind in the world, selling sunglasses made from recycled postconsumer metalized multi-layered plastic packaging (MLP) under the brand name WITHOUT. MLP generally ends up in landfills. It is a low-value, high-volume composite waste that is considered economically and technically “impossible” to recycle. The founder wanted to do something good out of the recycled stuff instead making money. Will Ashaya’s early breakthrough and now patented technology be able to bring significant change in the waste management system in India?

Complexity academic level
This case study is suitable for undergraduate BBA and postgraduate MBA courses.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 4: Environmental Management.
Tourists’ visit intention toward “libraries + cultural tourism”: a stimulus-organism-response perspective
Authors: Xu Xiaojuan , Wu Manli , Zhao Zerui , Pan Li 
Published: February 2025

Purpose
This study aims to investigate the factors that affect the tourists’ intention to visit “Libraries + cultural tourism (LCT)” and enhance the quality of LCT to attract tourists.

Design/methodology/approach
An online survey was conducted with 249 LCT tourists in China. By integrating LCT characteristics into the stimulus-organism-response framework, a research model was developed to examine the factors that predict tourists’ intention to visit LCT. The research model was tested using AMOS 24.0.

Findings
The results show that social function significantly influences tourists’ flow experience, which in turn affects their intention to visit LCT. Entertainment function and knowledge seeking function have significant impacts on tourists’ social presence, flow experience and perceived knowledge value, which further affect their intention to visit LCT. Flow experience is the strongest predictor of visit intention than social presence and perceived knowledge value. In particular, social presence, flow experience and perceived knowledge value partially mediate the relationships between LCT functions and tourists’ visit intention.

Originality/value
This study contributes to the LCT literature by identifying key factors that drive tourists’ intention to visit LCT projects. The findings have practical implications for enhancing the popularity of LCT.
Isogeometric boundary element formulation to simulate droplets in microchannel confinement
Authors: Gumus Ozgur Can , Kabacaoglu Gokberk , Cetin Barbaros 
Published: February 2025

Purpose
This study aims to present an isogeometric boundary element formulation that stably and accurately models the motion of a droplet with arbitrary viscosity in free flows and microchannel confinements.

Design/methodology/approach
Like other numerical methods, isogeometric boundary element formulation also suffers from mesh distortion; therefore, volume correction and mesh relaxation are also required for efficient and stable simulations of deformable particles in Stokes flow with high accuracy. To improve the stability and accuracy of the proposed formulation, (i) volume correction and (ii) mesh relaxation algorithms to prevent mesh distortion are implemented.

Findings
Several test cases for a droplet in free-space shear flow are demonstrated for different Ca and viscosity ratio values which determine the deformability of a droplet. The results reveal that the drift of the enclosed volume inside a droplet and the mesh distortion becomes severe at low viscosity ratios and high Ca values, i.e. in the high deformability regime. The proposed numerical method integrating the stabilization algorithm enables the simulations at low spatiotemporal resolutions, even in extreme cases. The proposed method provides more than 10× speed-up compared to high-fidelity simulations without mesh relaxation. Efficient and accurate 3D simulations of droplets are also presented for simulations in microfluidic confinement.

Practical implications
The current formulation can be applied for many different microfluidic applications, and can be extended to tackle multiphysics simulations of multiple droplets in microchannel confinement.

Originality/value
The paper presents an isogeometric boundary element formulation with volume correction and mesh relaxation to model the motion of a droplet with arbitrary viscosity in free flows and microchannel confinements.
Appraising construction artisans health insurance enrolment to achieve sustainable development goal 3 in the informal sector: issues and solutions
Authors: Ebekozien Andrew , Aigbavboa Clinton , Ahmed Mohamed Ahmed Hafez , Samsurijan Mohamad Shaharudin , Aliu John 
Published: February 2025

PurposeIn developing countries, informal construction artisans are vital to economic growth. Governments encourage enrolment into micro health insurance schemes to sustain artisans’ well-being and achieve universal health coverage. The peculiarity associated with the informal construction artisans may hinder the scheme enrolment, particularly in Nigeria. It may threaten to improve achieving sustainable development goal 3 (good health and well-being). This study investigated the level of awareness and causes and suggested measures to improve micro health insurance policy enrolment for construction artisans in the informal sector and, by extension, improve the achievement of Goal 3.Design/methodology/approachThis study adopted face-to-face interviews to collect data in Lagos and Benin City, Nigeria. The researchers engaged 40 participants and achieved saturation at the 35th participant. The researchers manually analysed the collected data and reported the findings using the thematic approach.FindingsResults showed low enrolment of informal sector construction artisans into micro health insurance schemes and identified the contributory factors. This includes poor awareness and poor funding of micro health insurance schemes, lax expertise and understanding of the micro insurance market space, extreme poverty, poor medical services, uneducated clients/customers/consumers, etc.Originality/valueAs part of the study’s implications, it recommends that the government invest more in social health for the informal sector’s low-income earners to enhance accomplishing universal health coverage and, by extension, improve achieving Goal 3. This study may stir policymakers to call for a review of the National Health Insurance Authority Act 2022 with implementable and enforceable clauses to reduce uninsured informal sector construction artisans.
Blended learning trends and future directions: a systematic literature review and bibliometric analysis
Authors: Amarathunga Buddhini 
Published: February 2025

PurposeThe current study intended to conceptually and technically examine the literature on blended learning (BL) utilising a dual-focused approach with systematic literature review and bibliometric analysis. This study intends to address eight different research problem areas.: (1) the descriptive features of the retrieved empirical studies on BL, (2) the tendencies of the annual scientific production and the thematic evolution of BL, (3) the most relevant and high-impact sources in the field of BL, (4) how sources are clustering through Bradford’s Law of Scattering, (5) the most cited articles on BL, (6) the most relevant countries for BL, (7) the authors’ productivity through Lotka’s Law of Authors’ Scientific Productivity and (8) the trending research themes for future investigations in the field of BL.Design/methodology/approachThe current study analysed 5,809 articles extracted from the Scopus database through the systematic literature review and bibliometric analysis mapping approaches. The two primary tools used in the analysis were VOSviewer and Biblioshiny.FindingsThe results suggest that BL is a subject discipline that is growing progressively, with a remarkable 8.3% yearly growth in scientific output from 2000 to 2023 (October). Online teaching, e-learning, flipped classrooms, distance education, interactive learning environments, asynchronous learning, curriculum, computer-assisted instructions and online learning are the trending themes in the discipline of BL based on the keyword co-occurrence analysis and trend topic analysis. Moreover, motivation, self-regulated learning, flipped learning, self-efficacy, collaborative learning, simulation and social media themes are suggested future directions for further investigations on BL, according to the thematic map of keywords analysis.Originality/valueThe present study offers an extensive literature evaluation, which advances the BL conversation. The outcomes of this research are important for students, educators, legislators, regulators in the field of education and higher education and the community worldwide.
Critical drivers of changes in energy-saving behaviours in student housing in Northern Ghana
Authors: Anugwo Iruka Chijindu , Appau Miller Williams , Simpeh Fredrick , Attakora-Amaniampong Elvis 
Published: February 2025

Purpose
Energy saving in student housing has become a major challenge in the growing tertiary higher learning institutions in Africa. The purpose of this study is to evaluate the drivers of changes in energy-saving behaviours in student housing in Ghana.

Design/methodology/approach
This study is quantitative based on the theory of planned behaviour. A survey of 1,702 on-campus university student housing users in Northern Ghana was conducted using a simple random sampling technique. Behavioural drivers were conceptualised into two broad themes and analysed using the Partial Least Square Structural Equation Model tool.

Findings
The findings of this study accept the general view that behavioural factors affect energy saving. However, financial, indoor environmental quality and student housing energy management techniques positively determine changes in energy-saving behaviours in student housing than behavioural factors. Knowledge-related factors did not show any contribution to behavioural intentions of energy saving.

Practical implications
An all-inclusive energy-saving mechanism, highlighting improvement in student housing conditions, can enhance energy saving. Aside from this, increasing the attention to sustainability and energy efficiency programs in student housing environments can provide positive potential for energy saving in student housing.

Originality/value
Introducing the theory of planned behaviour in similar studies confirms the large contributions of behavioural drivers to energy saving. The additional exploration of other drivers in this study showcases the potential of influencing energy-saving decisions in student housing within the sub-Saharan sub-region.
The mediating role of sports team love in the relationship between cognitive engagement and eFANgelism
Authors: Amani David 
Published: February 2025

PurposeThis study aimed to examine the impact of cognitive engagement on eFANgelism through the mediating role of sports team love.Design/methodology/approachA conceptual model was designed to formulate hypotheses, which were then tested quantitatively through Partial Least Squares Structural Equation Modeling (PLS-SEM). Data for testing the model were collected from 313 sports fans of Young Africans Sports Club and Simba Sports Club in Dodoma City, Tanzania.FindingsThe study revealed that elevated levels of cognitive attention and absorption inspire sports fans to cultivate a strong passion and commitment to their team. In turn, these highly passionate and dedicated fans are motivated to express their loyalty through evangelistic behavior.Originality/valueBy contributing to the extension of brand evangelism into sports industry, this paper highlights the pivotal role of cognitive engagement in encouraging sports fans toward eFANgelism. This study is one of the few scholarly efforts to shed light on the mechanisms that can inspire fans to exhibit evangelistic behavior.
Reciprocal dedication in times of crisis: the role of professional association membership benefits, organizational social responsibility and indebtedness
Authors: Kang Jiyun , Jung Shinyong , Shin Hhye Won 
Published: February 2025

PurposeProfessional associations in the hospitality, tourism and events (HTE) industry are struggling to keep their members committed and engaged, especially in uncertain times of external crises. This study examines whether pre-crisis perceived benefits from membership lead to increased post-crisis organizational commitment and organizational citizenship, considering the moderating role of organizational social responsibility (OSR) and the mediating effect of perceived indebtedness.Design/methodology/approachTwo sequential studies were conducted. Study 1 was designed to test the effects of perceived benefits on organizational commitment and citizenship and the moderating effects of OSR. Study 1 used a survey of event association members for a more homogeneous sample, thereby increasing the internal validity of the initial findings. Subsequently, Study 2 tested the conceptual model with the addition of a mediator – perceived indebtedness – using the second survey with a larger sample from broader hospitality and tourism associations, thereby increasing the external validity of the findings. Data from both studies were analyzed using partial least squares structural equation modeling.FindingsStudy 1 found that perceived benefits (knowledge, networking and self-esteem) enhanced organizational commitment. When moderated by OSR, networking benefits increased organizational citizenship, a more proactive form of reciprocal dedication. Study 2 confirmed perceived indebtedness as a significant mediator.Originality/valueThis paper is among the first to frame organizational commitment and citizenship as reciprocal dedication and to conceptually propose and empirically confirm indebtedness as an explicit mediator, providing robust evidence for the theory of indebtedness. The findings also offer practical implications, suggesting strategic directions for professional associations to effectively communicate their OSR initiatives to members, provide enhanced networking opportunities and cultivate perceived indebtedness.
Exploring the shopping experiences of visually impaired consumers: a scoping literature review
Authors: Thadikaran Greeshma Benny , Singh Sandeep Kumar 
Published: February 2025

Purpose
This study aims to synthesize the literature on shopping experiences of visually impaired consumers (VIC). The review probes the extent of the research done, highlights the shopping experiences of VIC documented in the existing literature, pinpoints gaps and provides directions for future research.

Design/methodology/approach
This study uses Arksey and O’Malley’s framework to conduct a scoping review. Articles related to VIC shopping experience were collected from Scopus databases. In total, 27 articles that met the inclusion criteria were selected for the review.

Findings
The results were divided into three sections. The analysis section conveys the extent of the research relevant to the methodology, study context, geographical location, timeline and citation analysis. The emerging themes portray the experiences VIC encounters while shopping. Finally, the consultation process revealed the current perspectives of VIC.

Practical implications
This review collates the existing literature and identifies the research gaps. These research gaps provide directions for future research. This study creates awareness of VIC shopping needs.

Originality/value
To the best of the authors’ knowledge, this is the first study to review the literature on VIC’s shopping experience.
Real Estate Insights: Reshaping the skills of future property professionals: the IDEA framework
Authors: Cheung Ka Shing 
Published: February 2025

PurposeThe property profession is in the midst of significant change, driven by new technologies, evolving societal needs and the growing emphasis on sustainability. This article explores how property professionals can adapt to these changes using the IDEA framework – integration, digitisation, engagement and adaptability. The goal is to outline the essential skills and strategies that can help professionals stay relevant and effective in a rapidly changing industry.Design/methodology/approachInformed by discussions at the Pacific Rim Real Estate Society (PRRES) 2025 conference, this article combines academic insights with industry expertise. By examining each pillar of the IDEA framework, the article provides practical examples and case studies of how property professionals can integrate new technologies, digitise their practices, engage with key stakeholders and remain adaptable to the evolving demands of the sector.FindingsThe research reveals that the future of property professionals hinges on their ability to integrate diverse areas of knowledge, such as data science, urban planning and environmental considerations, into their work. Technology, particularly AI and geospatial data, is transforming property valuation, but professionals must also address the challenges of bias and transparency. Engagement with stakeholders – from regulators to local communities – is crucial for ensuring ethical practices, while adaptability through continuous learning, internships and real-world experience is key to thriving in this fast-changing field.Practical implicationsThe findings underscore the need for property professionals to stay ahead of technological advancements and market shifts by embracing ongoing learning and practical experience. Suggestions include incorporating geospatial data into property assessments, developing ethical guidelines for AI and promoting flexible career paths through industry internships and active learning. These strategies will help professionals keep pace with industry change and enhance the profession’s long-term resilience.Originality/valueThis article presents a unique approach to preparing property professionals for the future, focusing on the practical application of the IDEA framework. It offers a fresh perspective on integrating technology, ethics and multidisciplinary collaboration into everyday practice. The article contributes valuable insights bridging the gap between academic theory and real-world application, providing thought leadership and actionable guidance for the profession.