bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resveratrol ameliorates bisphenol A-induced testicular toxicity in adult male rats: A stereological and functional study
Authors: Bordbar Hossein , Yahyavi Seyedeh-Saeedeh , Noorafshan Ali , Aliabadi Elham , Naseh Maryam 
Published: March 2022

Abstract
Bisphenol A (BPA) is one of the most widely used synthetic chemicals worldwide. BPA as an endocrine disruptor affects the reproductive systems through estrogenic and antiandrogenic proprieties. Resveratrol (RES) as a natural polyphenol and potent antioxidant exhibits the protective effects against reproductive toxicity by inhibition of oxidative stress. 48 male rats divided into eight groups (n = 6), including control (CON), Olive oil (0.5 ml/ day), Carboxy methylcellulose (CMC) (1 ml of 10 g/l), RES (100mg/kg/day), low dose of BPA (25 mg/kg/day), high dose of BPA (50 mg/kg/day), low dose of BPA + RES, and high dose of BPA + RES. All treatment were done orally by gavages per day for 56 days. At the end of the 8th week, blood samples were collected for hormone assays. Then, the sperm parameters were analyzed, and the left testis was removed for stereological study. We showed a significant decrease in sperm parameters in the low and high doses of BPA groups compared to control group (P < 0.05). The volume of testicular components as well as the diameter and length of seminiferous tubules significantly reduced (11–64%), and the total number of the testicular cell types decreased (34–67%) on average in the low and high doses of BPA groups. Moreover, serum FSH, LH, and testosterone hormones concentration showed a significant reduction in both doses of BPA groups (P < 0.01). Nonetheless, treatment with RES could ameliorate all the above-mentioned changes in the low and high doses of BPA groups (P < 0.05). RES could prevent BPA-induced testicular structural changes and sperm quality via improving gonadotropin hormones and testosterone levels.
Radiogenomic Analysis of Vascular Endothelial Growth Factor in Patients With Glioblastoma
Authors: Chen Baoshi , zheng fei , Zhang Lingling , Shen Huicong , Chen Hongyan , Zang Yuying , Li Yiming , Chen Xuzhu 
Published: March 2022

Abstract
Purpose Vascular endothelial growth factor (VEGF) is very important for glioblastoma (GBM) angiogenesis. This study is to predict VEGF expression in cerebral GBM by radiomic analysis.Methods We analysed the axial T2WI and T1-weighted contrast-enhancement (T1CE) images of preoperative MRI in 217 patients with pathologically diagnosed GBM. Patients were divided into negative and positive VEGF groups, with the latter group further subdivided into low and high expression and analysed by the machine learning model built by the maximum relevance and minimum redundancy (mRMR) algorithm and the extreme gradient boosting (XGBoost) classifier. The area under the receiver operating curve (AUC) and accuracy were calculated for the training and validation sets. Results Positive VEGF in GBM was 63.1% (137/217), with a high expression ratio of 53.3% (73/137). To predict the positive and negative VEGF expression, seven radiomic features were selected with three features from T1CE and four from T2WI. The accuracy and AUC were 0.83 and 0.81, respectively, in the training set, and were 0.73 and 0.74, respectively, in the validation set. To predict high and low levels, seven radiomic features were selected, with two from T1CE, one from T2WI, and four from the data combinations of T1CE and T2WI. The accuracy and AUC were 0.88 and 0.88, respectively, in the training set, and 0.72, and 0.72, respectively, in the validation set. Conclusion The VEGF expression status in GBM can be predicted using a machine learning model. Radiomic features resulting from data combinations of different MRI sequences could be helpful for analysis.
Effectiveness of Prophylactic Antibiotics in Infection Prevention in Closed Lower-Limb Fracture Surgery
Authors: Jokar Rahmatollah , Esmaeilnejadganji Seyyed Mokhtar , Bijani Ali , Ahangar Sekineh kamali , Shafeei Nahid 
Published: March 2022

Abstract
Background:‌ Postoperative infection is a major orthopedic problem that can be reduced by prescribing antibiotics to prevent surgical infection as an effective strategy. Therefore, the present study aimed to evaluate the effectiveness of prophylactic antibiotics to prevent infection in closed lower limb fracture surgery. Methods:‌ The present study was conducted on all patients with closed lower limb fracture from hip to the ankle that underwent Open reduction and internal fixation ‌(ORIF)‌ by a surgeon and received antibiotics and prophylactic antibiotics. The patients who received cefazolin prophylactic antibiotics 1 hour before surgery and 24 hours after surgery were put into the first group. Those receiving cefazolin prophylactic antibiotics 1 hour before surgery and up to 72 hours after surgery were put into the second group. It should be noted that the criterion for the presence of infection was the physician’s clinical judgment based on clinical manifestations such as heat, redness and swelling, pain and infectious secretions, and laboratory tests. Results:‌ Of 140 patients with closed lower limb fractures, two patients‌ (1.4%)‌were infected in each group. The culture of two patients with infection resulted in Staphylococcus aureus, and both patients showed fever and chill symptoms. Infection rates in patients, who received prophylactic antibiotics for 24 hours, had no significant difference with those who received antibiotics for 72 hours ‌(p=0.99).Conclusion:‌ Based on the present study results, the 24-hour prophylactic antibiotic administration to reduce risks of postoperative infection of the closed lower limb fracture in patients can be a suitable alternative for the long-term use of antibiotics.
Evaluating the genetic relationship between spondyloarthritis and human plasma proteins: Linkage disequilibrium score regression
Authors: Xu Jiawen , Si Haibo , Zeng Yi , Wu Yuangang , Shen Bin 
Published: March 2022

Abstract
Background: Spondyloarthritis (SpA) is a kind of complex bone disease influenced by genetic factors, environment, and lifestyles. In recent years, the impact of human plasma proteins on the development of SpA has been reported. However, the genetic relationships between human plasma proteins and SpA have not systematically studied.Methods: The genome-wide association study (GWAS) summary dataset of SpA was derived from a published study, involving a total of 452,264 White British individuals (3,966 SpA patients and 448,298 controls). The GWAS summary dataset for 3,622 human plasma proteins was derived from the published study. Consequently, linkage disequilibrium score regression (LD score regression) analysis was performed to evaluate the genetic correlations between each human plasma protein and SpA. The significant plasma proteins were further compared with the differentially expressed genes (DEGs) detected by the mRNA expression profiles of SpA.Results: For LD score regression analysis, 5 kinds of human plasma proteins were found to be associated with SpA, such as Testis-specific chromodomain protein Y 1(rg =0.2973, P value=0.0439), Interleukin-17D (rg =0.3890, P value=0.0381), Neurensin-1(rg =0.3667, P value=0.0333), Trypsin-2(rg =0.3653, P value=0.0380), Serpin A9(rg =0.3746, P value=0.0424). Among them, IL-17D is the common gene identified for SpA both at protein level and gene expression level (P protein value=0.0006, P mRNA value=0.0381).Conclusions: We identified several SpA associated human plasma proteins. Our novel findings may provide new ideas for the future study of the genetic mechanism of SpA.
Cost-Based Analyses of Random Neighbor and Derived Sampling Methods
Authors: Novick Yitzchak , Bar-Noy Amotz 
Published: March 2022

Abstract
Random neighbor sampling, or RN , is a method for sampling vertices with a mean degree greater than that of the graph. Instead of na¨ıvely sampling a vertex from a graph and retaining it (‘random vertex’ or RV), a neighbor of the vertex is selected instead. While considerable research has analyzed various aspects of RN , the extra cost of sampling a second vertex is typically not addressed. This paper explores RN sampling from the perspective of cost. We break down the cost of sampling into two distinct costs, that of sampling a vertex and that of sampling a neighbor of an already sampled vertex, and we also include the cost of actually selecting a vertex/neighbor and retaining it for use rather than discarding it. With these three costs as our cost-model, we explore RN and compare it to RV in a more fair manner than comparisons that have been made in previous research. As we delve into costs, a number of variants to RN are introduced. These variants improve on the cost-effectiveness of RN in regard to particular costs and priorities. Our full cost-benefit analysis highlights strengths and weaknesses of the methods. We particularly focus on how our methods perform for sampling high-degree and low-degree vertices, which further enriches the understanding of the methods and how they can be practically applied. We also suggest ‘two-phase’ methods that specifically seek to cover both high-degree and low-degree vertices in separate sampling phases.
Light color efficiency-balanced trans-palpebral illumination for widefield fundus photography of the retina and choroid
Authors: Son Taeyoon , MA JIECHAO , TOSLAK DEVRIM , ROSSI ALFA , KIM HOONSUP , Chan Robison , Yao Xincheng 
Published: March 2022

Abstract
A wide-field fundus camera, which can selectively evaluate the retina and choroid, is desirable for better detection and treatment evaluation of eye diseases. Trans-palpebral illumination has been demonstrated for wide-field fundus photography, but its application for true-color retinal imaging is challenging due to the light efficiency delivered through the eyelid and sclera is highly wavelength dependent. This study is to test the feasibility of true-color retinal imaging using efficiency-balanced visible light illumination, and to validate multiple spectral imaging (MSI) of the choroid. 530 nm, 625 nm, 780 nm and 970 nm light emission diodes (LED)s are used to quantitatively evaluate the spectral efficiency of the trans-palpebral illumination. In comparison with 530 nm illumination, the 625 nm, 780 nm and 970 nm light efficiencies are 30.25, 523.05, and 1238.35 times higher. The light efficiency-balanced 530 nm and 625 nm illumination control can be used to produce true-color retinal image with contrast enhancement. The 780 nm light image enhances the visibility of choroidal vasculature, and the 970 nm image is predominated by large veins in the choroid. Without the need of pharmacological pupillary dilation, a 140° eye-angle field of view (FOV) is demonstrated in a snapshot fundus image. In coordination with a fixation target, the FOV can be readily expanded over the equator of the eye to visualize vortex ampullas.
Prevalence, psychiatric correlates, and psychosocial determinants of illicit substance use among UK undergraduate students
Authors: Akram Umair , Foster Holly 
Published: March 2022

Abstract
This study examined the prevalence of illegal drug use in UK students and motivators behind such behaviour. Additionally, we explored possible relationships between substance use, psychosocial motivators, and psychiatric distress. N=543 students completed online measures of substance use, anxiety, depression, perceived stress, insomnia. A series of reasons behind their use were ranked based on importance. Reported cannabis, cocaine, nitrous oxide, ketamine and MDMA use were most prevalent based on lifetime, past year, and month assessments. The experience of anxiety, depression, perceived stress, and insomnia were related to increased reports of substance use. Poor self-confidence and self-medication were key motivators of illicit drug use in those presenting greater psychiatric distress. These outcomes add to the sparse body of literature concerning illicit substance use in relation to psychiatric distress amongst UK students. Furthermore, we provided novel insight into the psychosocial motivators of such use.
A neutron diffraction study of boussingaultite, (NH4)2[Mg(H2O)6](SO4)2
Authors: Gatta G. Diego , Guastella Giorgio , Guastoni Alessandro , Gagliardi Valentina , Cañadillas-Delgado Laura , Fernandez-Diaz Maria Teresa 
Published: March 2022

Abstract
The crystal structure and chemical composition of boussingaultite from Pécs-Vasas, Mecsek Mountains, South Hungary, were investigated by single-crystal neutron diffraction (at 20 K) along with a series of chemical analytical techniques [i.e., gravimetric determination of sulfates, EDTA titrimetric determination of magnesium, ion selective electrode for F and Cl, indirect gravimetric determination of ammonium as (NH4,Rb,Cs,K) tetraphenylborate, inductively coupled plasma atomic emission spectroscopy for REE and other minor elements, elemental analysis for C, N, and H content, high-T mass loss for H2O content]. The concentrations of more than 50 elements were measured. The experimental formula of the boussingaultite is: [(NH4)1.77K0.22)Σ1.99[(Mg0.95Mn0.06)Σ1.01(H2O)5.7](SO4)1.99. Neutron data analysis confirms that the structure of boussingaultite is built up by isolated Mg(H2O)6-octahedra, along with isolated NH4- and SO4-tetrahedra connected by a complex H-bonds network. Mg2+ is completely solvated by H2O molecules in a typical octahedral bonding configuration. All the seven independent oxygen sites in the structure are involved in H-bonds, as donors or as acceptors. The geometry of all the H2O molecules, bonded to Mg, is in line with that usually observed in crystalline compounds. The H2O molecules show moderate-strong H-bonds, with H···Oacceptor and Odonor···Oacceptor ranging between 1.72–1.87 and 2.70–2.84 Å, respectively, along with Odonor-H···Oacceptor angles between 168–178°. The four independent N-H···O bonds show H···Oacceptor and Ndonor···Oacceptor distances ranging between 1.81–2.00 and 2.84–2.98 Å, respectively, with N-H···O angles between 158–176°. All the H-bonds of the H2O molecules and of the NH4-group involve the oxygen sites of the SO4-group as acceptors: the SO4-group is, therefore, the “bridging unit” between the NH4 and the Mg(H2O)6 units, via H-bonds. Our structure refinement proved, unambiguously, that the partial K+ vs. NH4+ replacement generates a local disorder. K lies at the N site, and its bonding configuration can be described by a distorted polyhedron with CN = 8. However, the K+ vs. NH4+ replacement implies a change in the configuration of the SO4-tetrahedron, through a sort of rotation of the polyhedron. This is the first evidence of the presence of a partial picromerite component in the boussingaultite structure, which gives rise to a local disorder likely due to the significantly different bonding configurations of the two cations. Our refinement also revealed that Mn2+ replaces Mg2+ at the Mg site. No evidence of distortion of the octahedron is observed in response to such a replacement, but the fraction of Mn2+ is modest. An analysis of previous Raman and IR results is provided, and is compared with the experimental results of this study.
The structure and content of special customs statistics as a data source for the economic analysis of customs payments
Authors: Попов В.В. 
Published: March 2022

Статья посвящена вопросам рассмотрения содержания одного из направлений деятельности таможенных органов - ведения специальной таможенной статистики, с позиции ее дальнейшего применения как эмпирической базы проведения экономического анализа таможенных платежей как вида экономической деятельности таможенных органов. Также затрагиваются и международные аспекты ведения таможенной статистики как основы получения необходимой информации в области внешней торговли, деятельности таможенных органов и ряда смежных междисциплинарных вопросов.
The article is devoted to the issues of considering the content of one of the activities of customs authorities - maintaining special customs statistics, from the point of view of its further application as an empirical basis for economic analysis of customs payments as a type of economic activity of customs authorities. The international aspects of customs statistics are also touched upon as the basis for obtaining the necessary information in the field of foreign trade, the activities of customs authorities and a number of related interdisciplinary issues.
Scientific and industrial cooperation as a factor in the development of entrepreneurship in the region
Authors: Иванов С.Л. 
Published: March 2022

В данной статье рассматривается влияние научно-производственной кооперации (НПК) на развитие предпринимательства в регионе. Для этого были использованы данные мониторинга состояния малого и среднего предпринимательства, проведенного Вологодским научным центром Российской академии наук при участии автора. Было доказано, что НПК является одним из значимых инструментов развития предпринимательства. В частности, предприятия, участвующие в научно-производственной кооперации, способны повышать свою конкурентоспособность на внешних рынках, создавать новые рабочие места (в том числе, высокотехнологичные).
This article examines the impact of scientific and industrial cooperation (RPC) on the development of entrepreneurship in the region. For this, we used data from monitoring the state of small and medium-sized businesses, carried out by the Vologda Scientific Center of the Russian Academy of Sciences with the participation of the author. It has been proven that CPD is one of the most important tools for the development of entrepreneurship. In particular, enterprises participating in scientific and industrial cooperation are able to increase their competitiveness in foreign markets, create new jobs (including high-tech ones).
Methodology for constructing a static regression multifactor model from experimental data with factor scheduling of a fiber optic gyroscope
Authors: Скворцов В.С. , Лазаренко О.И. 
Published: March 2022

В статье обосновывается использование полного факторного эксперимента, как основного для исследования волоконно-оптического гироскопа. Показаны этапы построения регрессионных многофакторных моделей, полученных на основе результатов активного эксперимента. Также на основе модели волоконно-оптического гироскопа, построенной в вычислительно среде Matlab/Simulink, проведен анализ выбора основных характеристик, которые могут выступать как факторы необходимые для проведения полного факторного эксперимента и получения адекватной математической модели.
The article substantiates the use of a full factorial experiment as the main one for the study of fiber-optic gyroscopes. The stages of constructing regression multifactor models obtained based on an active experiment are shown. Also, based on the fiber-optic gyroscope model built in the Matlab/Simulink computing environment, the analysis of the selection of the main characteristics that can act as factors necessary for conducting a complete factor experiment and obtaining an adequate mathematical model is carried out.
Study of neural network approach application in face detection problem
Authors: Крысин И.А. , Гаврилов К.А. 
Published: March 2022

В статье приводится исследование применения сверточных нейронных сетей с разными структурами при решении задачи обнаружения лиц. Приводятся тесты и сравнение эффективности в сравнении с алгоритмом Viola-Jones по оценкам точности и скорости обработки. Проверяется точность при обнаружении лиц с очками. Результаты доказали возможность применения нейросетевого подхода. В статье описываются возможные варианты применения нейронных сетей в гибриде с алгоритмом Viola-Jones для более эффективного решения.
The article brings study of convolutional neural network with various structures application in face detection problem. Tests and effectiveness comparison to Viola-Jones algorithm are carried out in terms of accuracy and speed of processing. Accuracy on face detection with glasses is tested. Results proved the ability of neural network approach application. The article describes possible options of using neural networks with Viola-Jones algorithm to improve performance on the solution.
Investigating the effects of climate change, drought, and agricultural sector policies on the trend of the water poverty index in Iran
Authors: Yazdi Nabeallah , Mousavi Seyed Nematollah , Zarei Abdol Rassoul , Shirvanian Abdoulrasool 
Published: March 2022

Abstract
Since climate change, intermittent droughts with various severities, poor management and uncontrolled abstraction of water resources, and inattention to the balance of these resources have caused the water crisis in recent decades, it is vitally important to study the water scarcity, its changes in the future, and the effect of climate change and drought on the scarcity through appropriate management policies in the agricultural sector. To achieve this goal, the present study selected the Fasa plain in Iran and calculated its water poverty index (WPI) from 2008 to 2018 using parametric and non-parametric statistical tests. Also, the study calculated the correlation coefficient between the WPI and climate change and drought in the study area. It then evaluated the effects of water resources management policies in the agricultural sector on the poverty index. The results showed that water consumption had the greatest weight in calculating the WPI. The WPI has fluctuated between 0.297 and 0.678 in the Fasa plain, and the worst situation of water poverty was experienced in 2014. Despite its insignificance, the downward trend in the WPI showed that water resources management has become more unfavorable over time. Finally, it was concluded that the WPI in the Fasa plain was more dependent on drought than on climate change in the short term. Therefore, managing water resource consumption in this plain is vitally important, especially in drought conditions. The results also showed that reducing water consumption in the agricultural sector can significantly improve the WPI. Therefore, solving the water crisis in this plain, given the drought conditions and its future trend, requires policies improving water-use efficiency in the agricultural sector.
A lab-scale study on the influence of the compost-dewatering process on moisture removal and pathogen inactivation in pre-sanitized fecal sludge
Authors: Odey Emmanuel Alepu , Odey John Adinya , Li Zifu , Zhou Xiaoqin 
Published: March 2022

Abstract
In many developing cities, fecal sludge management has become a serious environmental issue. As the increasing urban settlement results in the generation of fecal matter that causes environmental problems, recovering and recycling fecal waste for soil amendment could be beneficial. In this study, pre-sanitized fecal sludge (FS) was collected from the ongoing FS treatment process at the University of Science and Technology Beijing and subjected to a compost-dewatering process to mitigate pathogen and moisture content (MC). Biochar and dry leaves were added to reactors 1, 2, and 3 (1:1, 2:1, and 3:1) at 10% to facilitate the degradation process. The result shows that the final MC from the 45-day experiment has values of 35.1, 37.3, 38.9, and 65% in reactors 1, 2, 3, and the control, respectively. The indicator organism (fecal coliform) was completely mitigated in reactors 1 and 2. However, fecal coliform was merely reduced from 7.2 to 5.7 log10 CFU/100 mL in reactor 3 and remained available in the control reactor. This phenomenon of pathogen inactivation and MC removal from FS was attributed to the concentration of lactic acid bacteria (LAB) in the pre-sanitized FS. The addition of LAB to the treatment process enhanced the acidification process and resulted in pathogen inactivation. Biochar and dry leaves also played an important role in mitigating moisture and enhancing the fast composting process. Given the hygienic condition of the compost, it is suitable for soil amendment in agriculture.