bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global and regional estimates of orphans attributed to maternal cancer mortality in 2020
Authors: Guida Florence , Kidman Rachel , Ferlay Jacques , Schüz Joachim , Soerjomataram Isabelle , Kithaka Benda , Ginsburg Ophira , Mailhot Vega Raymond B. , Galukande Moses , Parham Groesbeck , Vaccarella Salvatore , Canfell Karen , Ilbawi Andre M. , Anderson Benjamin O. , Bray Freddie , dos-Santos-Silva Isabel , McCormack Valerie 
Published: November 2022

AbstractDespite women being disproportionally affected by cancer deaths at young ages, there are no global estimates of the resulting maternal orphans, who experience health and education disadvantages throughout their lives. We estimated the number of children who became maternal orphans in 2020 due to their mother dying from cancer in that year, for 185 countries worldwide and by cause of cancer-related death. Female cancer deaths—by country, cancer type and age (derived from GLOBOCAN estimates)—were multiplied by each woman’s estimated number of children under the age of 18 years at the time of her death (fertility data were derived from United Nations World Population Prospects for birth cohort), accounting for child mortality and parity-cancer risk associations. Globally, there were 1,047,000 such orphans. Over half of these were orphans due to maternal deaths from breast (258,000, 25%), cervix (210,000, 20%) and upper-gastrointestinal cancers (136,000, 13%), and most occurred in Asia (48%: India 15%, China 10%, rest of Asia 23%) and Africa (35%). Globally, there were 40 new maternal orphans due to cancer per 100,000 children, with a declining trend with a higher Human Development Index (range: 121 in Malawi to 15 in Malta). An estimated 7 million children were prevalent maternal orphans due to cancer in mid-2020. Accelerating the implementation of the World Health Organization’s cervical and breast cancer initiatives has the potential to avert not only millions of preventable female cancer deaths but also the associated, often-overlooked, intergenerational consequences of these deaths.
Observation of Rayleigh-Lamb waves generated by the 2022 Hunga-Tonga volcanic eruption with the POLA detectors at Ny-Ålesund
Authors: Abbrescia M. , Avanzini C. , Baldini L. , Ferroli R. Baldini , Batignani G. , Battaglieri M. , Boi S. , Bossini E. , Carnesecchi F. , Casula M. , Cavazza D. , Cicalò C. , Cifarelli L. , Coccetti F. , Coccia E. , Corvaglia A. , Gruttola D. De , Pasquale S. De , Galante L. , Garbini M. , Gemme G. , Gnesi I. , Gramstad E. , Grazzi S. , Haland E. S. , Hatzifotiadou D. , Rocca P. La , Liu Z. , Lombardo L. , Mandaglio G. , Margotti A. , Maron G. , Mazziotta M. N. , Mazzola M. , Mulliri A. , Nania R. , Noferini F. , Nozzoli F. , Ould-Saada F. , Palmonari F. , Panareo M. , Panetta M. P. , Paoletti R. , Parvis M. , Pellegrino C. , Perasso L. , Pinazza O. , Pinto C. , Pisano S. , Riggi F. , Righini G. , Ripoli C. , Rizzi M. , Sartorelli G. , Scapparone E. , Schioppa M. , Scioli G. , Scribano A. , Selvi M. , Taiuti M. , Terreni G. , Trifirò A. , Trimarchi M. , Viola A. P. , Vistoli C. , Votano L. , Williams M. C. S. , Zichichi A. , Zuyeuski R. 
Published: November 2022

AbstractThe eruption of the Hunga-Tonga volcano in the South Pacific Ocean on January 15, 2022, at about 4:15 UTC, generated a violent explosion, which created atmospheric pressure disturbances in the form of Rayleigh-Lamb waves detected all over the globe. Here we discuss the observation of the Hunga-Tonga shock-wave performed at the Ny-Ålesund Research Station on the Spitsbergen island, by the detectors of the PolarquEEEst experiment and their ancillary sensors. Online pressure data as well as the results of dedicated offline analysis are presented and discussed in details. Results include wave arrival times, wave amplitude measurements and wave velocity calculation. We observed five passages of the shock wave with a significance larger than 3 $$\sigma$$
σ
and an amplitude up to 1 hPa. The average propagation velocity resulted to be (308 ± 0.6) m/s. Possible effects of the atmospheric pressure variation associated with the shock-wave multiple passages on the cosmic-ray rate at ground level are also investigated. We did not find any significant evidence of this effect.
A familial case of MYH9 gene mutation associated with multiple functional and structural platelet abnormalities
Authors: Safiullina Svetlana I. , Evtugina Natalia G. , Andrianova Izabella A. , Khismatullin Rafael R. , Kravtsova Olga A. , Khabirova Alina I. , Nagaswami Chandrasekaran , Daminova Amina G. , Peshkova Alina D. , Litvinov Rustem I. , Weisel John W. 
Published: November 2022

AbstractMutations in the MYH9 gene result in macrothrombocytopenia often associated with hemorrhages. Here, we studied the function and structure of platelets in three family members with a heterozygous mutation R1933X in the MYH9 gene, characteristic of closely related disorders known as the May-Hegglin anomaly and Sebastian syndrome. The examination included complete blood count, blood smear microscopy, platelet flow cytometry (expression of P-selectin and active integrin αIIbβ3 before and after activation), the kinetics of platelet-driven contraction (retraction) of blood clots, as well as scanning/transmission electron microscopy of platelets. Despite severe thrombocytopenia ranging (36–86) × 109/l, none of the patients had hemorrhages at the time of examination, although they had a history of heavy menstruation, spontaneous ecchymosis, and postpartum hemorrhage. Flow cytometry showed background platelet activation, revealed by overexpression of P-selectin and active αIIbβ3 integrin above normal levels. After TRAP-induced stimulation, the fractions of platelets expressing P-selectin in the proband and her sister were below normal response, indicating partial platelet refractoriness. The initiation of clot contraction was delayed. Electron microscopy revealed giant platelets with multiple filopodia and fusion of α-granules with dilated open canalicular system, containing filamentous and vesicular inclusions. The novel concept implies that the R1933X mutation in the MYH9 gene is associated not only with thrombocytopenia, but also with qualitative structural and functional defects in platelets. Platelet dysfunction includes impaired contractility, which can disrupt the compaction of hemostatic clots, making the clots weak and permeable, therefore predisposing patients with MYH9 gene mutations to the hemorrhagic phenotype.
Predicting building types using OpenStreetMap
Authors: Atwal Kuldip Singh , Anderson Taylor , Pfoser Dieter , Züfle Andreas 
Published: November 2022

AbstractHaving accurate building information is paramount for a plethora of applications, including humanitarian efforts, city planning, scientific studies, and navigation systems. While volunteered geographic information from sources such as OpenStreetMap (OSM) has good building geometry coverage, descriptive attributes such as the type of a building are sparse. To fill this gap, this study proposes a supervised learning-based approach to provide meaningful, semantic information for OSM data without manual intervention. We present a basic demonstration of our approach that classifies buildings into eitherresidentialornon-residentialtypes for three study areas: Fairfax County in Virginia (VA), Mecklenburg County in North Carolina (NC), and the City of Boulder in Colorado (CO). The model leverages (i) available OSM tags capturing non-spatial attributes, (ii) geometric and topological properties of the building footprints including adjacent types of roads, proximity to parking lots, and building size. The model is trained and tested using ground truth data available for the three study areas. The results show that our approach achieves high accuracy in predicting building types for the selected areas. Additionally, a trained model is transferable with high accuracy to other regions where ground truth data is unavailable. The OSM and data science community are invited to build upon our approach to further enrich the volunteered geographic information in an automated manner.
Analysis of influence of deformation modes of retaining structures on deformation of a side shield tunnel
Authors: Wei Gang , Guo Binglai , Wang Zhe , Diao Hongguo , Wang Xinquan 
Published: November 2022

AbstractIn the process of foundation pit excavation, different retaining structures and support stiffness may lead to different deformation modes of retaining structures. The soil displacement cause by the deformation of the retaining structure is calculated by the virtual image technique. Meanwhile, the collaborative deformation model for rotation and dislocation is introduced to analyze the tunnel longitudinal deformation caused by different deformation modes as well as the tunnel maximum displacement equivalent field, and two case verifications are carried out. The study shows that there is a large difference in the size and distribution law of the soil displacement field caused by different enclosure structure deformation modes. The horizontal displacement of soil caused by the cantilever type always shows a "cantilever type" curve with increasing horizontal distance from the enclosure structure, while the composite type, inner convex type and kicker type develop from the "bow" to the "cantilever type" curve. The vertical displacement field of the soil is in the shape of a "spoon" and the soil exhibits a certain bulge deformation below the critical depth. The critical depths of the composite type and inner convex type are similar, while the kick type is the largest and the cantilever type is the smallest. The influence area of the maximum horizontal displacement of the tunnel outside the pit of the inner convex type and the composite type is basically the same. The influence area of the cantilever mode is the smallest, while the influence depth of the kick-in mode is higher than that of the other three deformation modes.
Impedance modelling and stability analysis of modular multilevel converter with different types of grid‐forming control schemes
Authors: Guo Hanlin , Zhang Zheren , Xu Zheng 
Published: November 2022

AbstractWith the increasing penetration of power electronics, grid‐forming modular multilevel converters (MMCs) have attracted great attention in the upcoming MMC‐based high‐voltage direct current transmission (HVDC) projects. Power synchronization control (PSC) and direct power control (DPC) are two typical grid‐forming control schemes for MMCs. This paper sets out to investigate the impedance‐based stability characteristics of PSC‐MMC and DPC‐MMC. Utilizing the harmonic state space (HSS), equivalent impedance models of PSC‐MMC and DPC‐MMC are developed with the consideration of complete controllers and MMC internal dynamic characteristics. Impedance shaping effects of the major controllers are further analyzed to identify the frequency bands where the MMCs have negative resistive impedance characteristics. Finally, potential instability phenomena of the interconnected system are shown through the case studies, and the virtual impedance method is introduced as the stabilization control scheme. The electromagnetic transient simulation results based on PSCAD/EMTDC verify the accuracy of the impedance models and the effectivity of the stabilization control scheme.
Catalyst-Free Synthesis of Phosphorothioates via P–S Coupling ­Reaction of Dialkyl Phosphites with Thiols
Authors: Kaboudin Babak , Daliri Payam , Esfandiari Hesam , Kazemi Foad 
Published: November 2022

AbstractA catalyst-free synthesis of phosphorothioates via a P–S cross-coupling reaction of thiols with dialkyl phosphites has been studied. With presented method, various phosphorothioates were obtained by the reaction of thiols with H-dialkyl phosphites in the presence of DMSO as both solvent and oxidant under transition-metal-free conditions. Mechanistic studies showed that the reaction proceeds with formation of a known disulfide intermediate via the oxidation of thiols in the presence of DMSO. Nucleophilic substitution of dialkyl phosphite with the disulfide intermediate gave phosphorothioate. The presented method is a convenient process for the synthesis of phosphorothioates under catalyst-free conditions.
Studies Towards the Total Synthesis of Populusone: Stereoselective Construction of Functionalized 2-Oxa-bicyclo[2.2.2]octenes
Authors: Schmalz Hans-Günther , Hemmersbach Lars 
Published: November 2022

AbstractA short and efficient synthetic access to functionalized compounds displaying major structural elements of the natural product populusone is elaborated by exploiting a diastereoselective Mukaiyama aldol addition followed by a triflic anhydride-induced oxa-Michael addition to construct the sensitive 2-oxa-bicyclo[2.2.2]octene unit as an enol triflate, which is directly used in a subsequent Suzuki cross-coupling. While attempts to close the strained 10-membered ring by means of Ru-catalyzed ring-closing metathesis were not successful, the developed synthetic scheme opens a rapid synthetic access to advanced intermediates, which may allow the completion of the total synthesis of populusone in the future.
Reassembly of Unsaturated C–C Bonds by a Cutting/Insertion Cascade
Authors: Jiang Yaojia , Xu Ying , Li Ling , Zhao Min 
Published: November 2022

AbstractThe reassembly of unsaturated C–C bonds has attracted widespread attention from synthetic chemists due to its advantages of unique reactivity, easy handling, and high atom and step economies. We recently explored a cutting/insertion cascade as a means of introducing a new C1 source and constructing functionalized 1,4-keto aldehyde and 2H-furan derivatives through cyclopropanation of enamines with various carbene precursors and subsequent ring-opening reactions in situ. Aminocyclopropanes are believed to be involved as key intermediates in these transformations. This Synpacts article outlines our recent contributions to this increasingly important research area.1	Introduction2	Cleavage of Enamine C=C Double Bonds and Hydrolysis to 1,4-Keto Aldehydes3	Cleavage of Enamine C=C Double Bonds and Cyclization to 2H-Furans4	Cleavage of Ynone/Ynoate C≡C Triple Bonds5	Conclusion
Effect of melatonin and nitric oxide on capacitation and apoptotic changes induced by epidermal growth factor in ram sperm
Authors: Miguel-Jiménez Sara , Carvajal-Serna Melissa , Peña-Delgado Victoria , Casao Adriana , Pérez-Pe Rosaura 
Published: November 2022

Context Apart from the canonical cAMP-PKA pathway, ram sperm capacitation can be achieved by the MAPK ERK1/2 signalling cascade, activated by epidermal growth factor (EGF). Aims This study aims to investigate the effect of melatonin and nitric oxide (NO·) on capacitation and apoptotic-like changes in EGF-capacitated ram spermatozoa. Methods In vitro capacitation was induced by EGF in the absence or presence of melatonin (100 pM or 1 μM). Also, a NO· precursor, L-arginine, or a NOS inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), were added to capacitation media to study the interaction of NO· and melatonin during EGF-capacitation. Sperm functionality parameters (motility, viability, capacitation state), apoptotic markers (caspase activation and DNA damage), NO· levels, and phosphorylated c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (assessed by Western blot), were evaluated in swim-up and capacitated samples with EGF. Key results NO· levels and the apoptotic-related markers were raised after EGF incubation. Melatonin had a bimodal role on sperm EGF-capacitation, preventing it at high concentration and promoting acrosome reaction at low concentration, but neither of the two concentrations prevented the increase in apoptotic-like markers or NO· levels. However, melatonin at 1 μM prevented the activation of JNK. Conclusions NO· metabolism does not seem to modulate the apoptosis-like events in ram spermatozoa. Melatonin at 1 μM prevents ram sperm capacitation induced by EGF independently from nitric oxide metabolism, and it could be exerted by limiting the JNK mitogen-activated protein kinase (MAPK) activation. Implications This study improves our understanding of the biochemical mechanisms involved in sperm capacitation, and ultimately, fertility.
Multivariate analysis of hydropedologically significant soil variables on cultivated semi-arid hillslopes
Authors: Kavaklıgil Seval Sünal , Erşahin Sabit 
Published: November 2022

Context Hydropedology bridges hydrology to pedology, and hillslope hydropedology is central in understanding topography–hydropedology interrelations. Aim The objective of this study was to statistically evaluate soil–hillslope hydropedology interrelations by multivariate analysis of hydropedologically significant soil variables (HSSVs). Methods A complete randomised 6 × 5 × 3 factorial experiment (six slope aspects, five slope positions and three soil horizons) was established. Twenty nine soil profiles were excavated and described on topslope, shoulder, backslope, footslope, and toeslope positions of hillslopes oriented in different directions. A total of 486 soil samples were taken from A, B, and C horizons at 174 sampling points and analysed for soil parametric properties. In addition, soil morphometric factors were described in the field and converted to their quantitative values. Relationships among HSSVs were analysed by Spearman’s correlation and principal component analysis. Association between HSSVs, soil horizonation and slope factors (slope aspect and position) was analysed by a multivariate factorial ANOVA. Results Slope aspect and slope position were dominant factors, which significantly affected (P < 0.05) variability in the majority of the HSSVs. Variability in clay and sand contents, bulk density, organic matter content, saturated hydraulic conductivity, and field capacity was significantly affected (P < 0.05) by these factors. Also, soil morphological variables of concentration factors (such as clay accumulation on the ped faces and pore walls), mottles, rupture resistance, stickiness, and plasticity were significantly (P < 0.05) controlled by these factors. Conclusions Clay content and abundance of concentration factors must be included in prospective similar studies, as they are key soil indicators of hydropedology. Implications Further studies should be conducted with different soils for an improved conceptualisation of hillslope-hydropedology interrelations.
Formation of tantalum coatings with a given structure on the surface of niti alloy by magnetron sputter deposition
Authors: Larionov А S , Dikov А S , Akayev S О , Dikova L А , Zhakanbayev Е А , Sarsenbaeva К B 
Published: November 2022

Abstract
Way for applying tantalum coating with a given structure to the surface of an alloy with a shape memory effect NiTi to increase the biocompatibility of implants from this alloy is presented. The coating was synthesized by direct current (DC) magnetron sputtering. The changes sequence of the structural-phase states depending on the thickness of the coating, that is, the rate of its deposition, has been established. It is shown that at a low magnetron power, ∼14 W in present study, a single-phase α-Ta coating with a bcc structure and a high degree of perfection of the crystal lattice is successfully synthesized on the titanium nickelide surface.
Medicine and Health “in the Least Civilized Regions”
Authors: Carey David 
Published: November 2022

Abstract
In nations with large Indigenous populations like Guatemala and Ecuador, overlapping narratives of nationalism, public health, and race signal the complexity of modernizing health care. Various variables—race, gender, class, geography, the role of the state, divisions within the ruling class—impinged on people’s health care decisions. To analyze how racial thought and public health influenced each other during Guatemala’s predominantly dictatorial rule and Ecuador’s authoritarian but more participatory government at a time when the most significant international public health organization—the Rockefeller Foundation (RF)—sought to improve public health in both countries, I combine transnational and comparative historical analyses of the first half of the twentieth century. Triangulating Guatemalan, Ecuadorian, and RF archives and focusing on the primacy of Indigenous voices reveals an interactive matrix of different types of racism in Guatemala, Ecuador, and RF that shaped indígenas’ (Indigenous people’s) engagement with, exclusion from, or rejection of public health initiatives and scientific medicine. The politics of indigeneity was as consequential for public health as scientific developments. Many state agents and RF representatives used public health contexts to mobilize social constructions of race and ethnicity that advanced their agendas and marginalized indígenas. In turn, indígenas often determined the extent to which authorities’ aspirations matched their accomplishments.
IPPF-FE: an integrated peptide and protein function prediction framework based on fused features and ensemble models
Authors: Yu Han , Luo Xiaozhou 
Published: November 2022

AbstractThe prediction of peptide and protein function is important for research and industrial applications, and many machine learning methods have been developed for this purpose. The existing models have encountered many challenges, including the lack of effective and comprehensive features and the limited applicability of each model. Here, we introduce an Integrated Peptide and Protein function prediction Framework based on Fused features and Ensemble models (IPPF-FE), which can accurately capture the relationship between features and labels. The results indicated that IPPF-FE outperformed existing state-of-the-art (SOTA) models on more than 8 different categories of peptide and protein tasks. In addition, t-distributed Stochastic Neighbour Embedding demonstrated the advantages of IPPF-FE. We anticipate that our method will become a versatile tool for peptide and protein prediction tasks and shed light on the future development of related models. The model is open source and available in the GitHub repository https://github.com/Luo-SynBioLab/IPPF-FE.
Label-free proteome quantification and evaluation
Authors: Fu Jianbo , Yang Qingxia , Luo Yongchao , Zhang Song , Tang Jing , Zhang Ying , Zhang Hongning , Xu Hanxiang , Zhu Feng 
Published: November 2022

Abstract
The label-free quantification (LFQ) has emerged as an exceptional technique in proteomics owing to its broad proteome coverage, great dynamic ranges and enhanced analytical reproducibility. Due to the extreme difficulty lying in an in-depth quantification, the LFQ chains incorporating a variety of transformation, pretreatment and imputation methods are required and constructed. However, it remains challenging to determine the well-performing chain, owing to its strong dependence on the studied data and the diverse possibility of integrated chains. In this study, an R package EVALFQ was therefore constructed to enable a performance evaluation on &gt;3000 LFQ chains. This package is unique in (a) automatically evaluating the performance using multiple criteria, (b) exploring the quantification accuracy based on spiking proteins and (c) discovering the well-performing chains by comprehensive assessment. All in all, because of its superiority in assessing from multiple perspectives and scanning among over 3000 chains, this package is expected to attract broad interests from the fields of proteomic quantification. The package is available at https://github.com/idrblab/EVALFQ.