bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polygenic scores, diet quality, and type 2 diabetes risk: An observational study among 35,759 adults from 3 US cohorts
Authors: Merino Jordi , Guasch-Ferré Marta , Li Jun , Chung Wonil , Hu Yang , Ma Baoshan , Li Yanping , Kang Jae H. , Kraft Peter , Liang Liming , Sun Qi , Franks Paul W. , Manson JoAnn E. , Willet Walter C. , Florez Jose C. , Hu Frank B. 
Published: April 2022

BackgroundBoth genetic and lifestyle factors contribute to the risk of type 2 diabetes, but the extent to which there is a synergistic effect of the 2 factors is unclear. The aim of this study was to examine the joint associations of genetic risk and diet quality with incident type 2 diabetes.Methods and findingsWe analyzed data from 35,759 men and women in the United States participating in the Nurses’ Health Study (NHS) I (1986 to 2016) and II (1991 to 2017) and the Health Professionals Follow-up Study (HPFS; 1986 to 2016) with available genetic data and who did not have diabetes, cardiovascular disease, or cancer at baseline. Genetic risk was characterized using both a global polygenic score capturing overall genetic risk and pathway-specific polygenic scores denoting distinct pathophysiological mechanisms. Diet quality was assessed using the Alternate Healthy Eating Index (AHEI). Cox models were used to calculate hazard ratios (HRs) for type 2 diabetes after adjusting for potential confounders. With over 902,386 person-years of follow-up, 4,433 participants were diagnosed with type 2 diabetes. The relative risk of type 2 diabetes was 1.29 (95% confidence interval [CI] 1.25, 1.32;P< 0.001) per standard deviation (SD) increase in global polygenic score and 1.13 (1.09, 1.17;P< 0.001) per 10-unit decrease in AHEI. Irrespective of genetic risk, low diet quality, as compared to high diet quality, was associated with approximately 30% increased risk of type 2 diabetes (Pinteraction= 0.69). The joint association of low diet quality and increased genetic risk was similar to the sum of the risk associated with each factor alone (Pinteraction= 0.30). Limitations of this study include the self-report of diet information and possible bias resulting from inclusion of highly educated participants with available genetic data.ConclusionsThese data provide evidence for the independent associations of genetic risk and diet quality with incident type 2 diabetes and suggest that a healthy diet is associated with lower diabetes risk across all levels of genetic risk.
Global, regional, and national burden and quality of care index in children and adolescents: A systematic analysis for the global burden of disease study 1990–2017
Authors: Hanifiha Melika , Ghanbari Ali , Keykhaei Mohammad , Saeedi Moghaddam Sahar , Rezaei Negar , Pasha Zanous Maryam , Yoosefi Moein , Ghasemi Erfan , Rezaei Nazila , Shahin Sarvenaz , Rashidi Mohammad-Mahdi , Ghamari Azin , Haghshenas Rosa , Kompani Farzad , Farzadfar Farshad 
Published: April 2022

Purpose
To express a global view of care quality in major causes of mortality and morbidity in children and adolescences

Methods
We used primary epidemiologic indicators from the Global Burden of Disease 1990–2017 database. We have created four secondary indices from six primary indices in order to assess the care quality parameters. We conducted a principal component analysis on incidence, prevalence, mortality, Years of Life Lost (YLLs), Years Lived with Disability (YLDs), and Disability Adjusted Life Years (DALYs) to create an index presented by quality-of-care index (QCI) to compare different countries.

Results
The global QCI scores of respiratory infection, enteric infection, leukemia, foreign body aspiration, asthma, epilepsy, diabetes mellitus, dermatitis, road injury, and neonatal disorders have improved remarkably. These causes showed equal distribution of qualified care for both sexes. The global trend of QCI score for mental health showed a steady pattern during the same time and disparities favoring females was evident. The quality of care for these causes was notably higher in developed areas.

Conclusions
The global QCI revealed a universal growth in major causes of death and morbidity in <20y during 28 years. Quality of care is an associate of the level of country’s development. Despite effective interventions, inequities still remain. Implementation of policies to invest in quality improvement and inequality elimination is needed.
“This topic was inconsiderate of our culture”: Jordanian students’ perceptions of intercultural clashes in IELTS writing tests
Authors: Altakhaineh Abdel Rahman Mitib , Melo-Pfeifer Sílvia 
Published: April 2022

Abstract
In this contribution, we analyse how students perceive and comment on potential instances of intercultural clashes in the writing component of the International English Language Testing System. Following student accounts, we argue that intercultural bias is indeed perceived, preventing test takers from fully positioning themselves regarding cultural practices in general, and religious beliefs more particularly, as well as from expressing their sociocultural identities. Analysing a corpus of interviews in Amman (Jordan) with Jordanian students who took the test, we uncover how student perceptions of elements that reflect the culture of the test creator negatively influenced their performance, or at least their perception of what constitutes a good performance, which they implicitly identify with like-mindedness and alignment with the test creator’s cultural expectations.
Zwei neuerschlossene Dokumente zur Frühgeschichte der Juden in Eslohe
Authors: Jütte Robert , Meiselman Louis 
Published: April 2022

Abstract
In the chronicle of the Catholic parish of Eslohe in Westphalia there are two Hebrew manuscripts that have not yet been edited or researched. Both provide a glimpse on religious life in a small Ashkenazi Jewish community at the end of the 18th century. One manuscript, dated March 9, 1800, contains the answer written by a certain Simon ben Eljakum on behalf of Joseph Friedländer from Padberg to a request from Jacob Zander from Eslohe regarding the creation of a mikveh, i. e. a ritual immersion bath. The second Hebrew manuscript, dated September 2, 1796, contains the text of a Hebrew eulogy that begins with a song that is sung in Jewish homes on Friday evening after dinner and begins with the Hebrew words zamah nafschi l'elohim (= my soul thirsts for God). Both manuscripts are examined and commented on here for the first time. In the appendix follows a complete transcription of both Hebrew (and partly also Yiddish) texts as well as a translation into German.
»Der Satan tanzt«: Rhetorische Strategien in der Responsa-Sammlung Ele Divre ha-Brit
Authors: Kramp-Seidel Nicola 
Published: April 2022

Abstract
Respondents construct their answers by implanting a style, using tropes and patterns of argumentations. Thereby, they intend to emphasize the correctness of their answer and to stage their authority. Due to this fact it is worthwhile to examine responsa as literature – one of two trends in the Law-and-Literature-Movement. In this paper I want to analyse the collection of responsa called Ele Divre ha-Brit. This collection of 22 responsa was edited in 1819 by the Bet Din (rabbinical court) of Hamburg in order to condemn the new reforms in Hamburg implemented by the reformers. My goal is to see if and how the febrile atmosphere is visible in rhetoric. It can be shown that a lot of tropes and stylistic devices are used to emotionalise the reader. But patterns of argumentations like »correctio« are used as well with the intention to stress the correctness of the answers.
Influence of surface modification on thermal, adhesive properties and impact behavior of TPU films for laminated glass
Authors: Zhang Chenxing , Wu Hongwu , Xu Liangfeng , Ren Mingyuan 
Published: April 2022

Abstract
The poor adhesion of TPU films limits their extensive application in lightweight laminated glass (LLG). A simple and effective method is reported in this paper to obtain modified TPU films by silane coupling agent (SCA) treatment. The polar groups (such as urethane groups, carboxyl groups, etc.) on the surface of TPU films reacted chemically with the reactive groups of SCA. Meanwhile, hydrogen bonds were formed between the silicon hydroxyl groups generated by the hydrolysis of SCA. Therefore, the adhesivity and thermal stability of TPU films were improved. Moreover, the surface of TPU films became rough after modification, hence the interfacial bonding area between TPU film and glass increased, which furthered the bonding effect of TPU film with glass plate. Compared with unmodified TPU films, the tensile shear bond strength (TSBS) of modified TPU films increased by nearly 28%, and the initial decomposition temperature increased from 277 °C to a maximum of 295.3 °C. The impact resistance of LLG was significantly improved due to the improvement of the adhesivity of TPU film.
A Dynamic SIqIRV Mathematical model with Non-linear Force of Isolation, Infection and Cure
Authors: Chatzarakis G. E. , Dickson S. , Padmasekaran S. 
Published: April 2022

Abstract
The Susceptible-Isolated-Infected-Recovered-Vaccinated (SIqIRV) deterministic model is examined in this paper. This model considers a nonlinear force of quarantine, infection and care, where vaccinated individuals lose their immunity after a period of time and become susceptible to infection. Isolation is the main key to bringforth the SIq
IRV model. The fundamentals of reproduction number calculated using this model is an outbreak threshold that decides whether or not a disease can spread. The infection free steady state solutions are locally and globally found to be asymptotically stable when R
0 < 1. Infection persistent steady state solutions are also found to be locally asymptotically stable when R
0 > 1. At the end, computational simulations were run to confirm and support our theoretical findings.
In-silico elucidation reveals potential phytochemicals against angiotensin-converting enzyme 2 (ACE-2) receptor to fight coronavirus disease 2019 (COVID-19)
Authors: Khalid Hina , Khalid Sana , Sufyan Muhammad , Ashfaq Usman Ali 
Published: April 2022

Abstract
The coronavirus (SARS-CoV-2) pandemic is rapidly advancing and spreading worldwide, which poses an urgent need to develop anti-SARS-CoV-2 agents. A human receptor, namely, angiotensin-converting enzyme 2 (ACE-2), supports the SARS-CoV-2 entry, therefore, serves as a target for intervention via drug. In the current study, bioinformatic approaches were employed to screen potent bioactive compounds that might be ACE-2 receptor inhibitors. The employment of a docking study using ACE receptor protein with a ready-to-dock database of phytochemicals via MOE software revealed five compounds as potent molecules. Among them, astragaloside exhibited the highest binding affinity −21.8 kcal/mol and stable interactions within the active site of the ACE-2 receptor. Similarly, the phytochemicals such as pterocaryanin B, isoastragaloside II, and astraisoflavan glucoside followed by oleuropein showed a stronger binding affinity. We hypothesize these compounds as potential lead candidates for the development of anti- COVID-19 target-specific drugs.
Studi Aliran Daya pada CCR 1 dan CCR 2 Proyek Otomatisasi Sistem Kontrol Unit 1, 2, 3 dan 4 Area Geothermal Lahendong
Authors: Armanjaya Agus Jaya 
Published: April 2022

Studi aliran daya pada CCR 1 dan CCR 2 proyek otomatisasi sistem kontrol unit 1, 2, 3 dan 4 Lehendong merupakan studi yang dilakukan untuk memverfikasi hasil perencanaan yang sudah dilakukan sebelum dilakukan proses order material, konstruksi dan komisioning. Dengan studi aliran daya dapat diketahui karakteristik dari peralatan-peralatan yang akan dipasang, seperti kemampuan pembebanan suatu transformator,Â kamampuan suplai emergency diesel generator pada saat terjadi gangguan suplai listrik dari PLN dan nilai tegangan dan arus pada masing-masing bus. Berdasarkan hasil pengujian didapatkan bahwa pada kondisi normal operation nilai tegangan terendah pada CCR 1 dan CCR 2 terjadi pada bus LHD4-BGD01-GS003-Q02 yaitu sebesarÂ 98,649 %. Sedangkan pada kondisi emergency operation nilai tegangan terendah pada CCR 1 dan CCR 2 terjadi pada bus LHD4-BGD01-GS003-Q02 yaitu sebesar 99,567 % dari tegangan nominal.Kata kunci: Otomatisasi, geothermal, CCR, sistem kontrol
POTENSI TINGKAT PERTUMBUHAN TANAMAN AREN (Arenga pinnata MERR.) DI KABUPATEN HULU SUNGAI TENGAH KALIMANTAN SELATAN
Authors: Naemah Dina , Payung Damaris , Karni Fauzi 
Published: April 2022

Arenga pinnata is a plant that has potential for the community as a source of income that can improve the welfare of the community because most of them get a source of income from processing this plant. Almost all parts of the sugar palm plant can be utilized, from the roots to the male flower bunches that can produce sap.Plant structure is the organization of individuals in space and composition is the arrangement of forest stands that includes the number of species or the number of individuals. Composition means also studying the distribution of a plant species based on density, frequency and dominance value. Vegetation structure is the result of spatial planning by stand components or plant communities in a community both vertically and horizontally. The purpose of this study was to determine the potential distribution of sugar palm growth rates in one of the districts in South Kalimantan, Hulu Sungai Tengah. The analysis was carried out by calculating the significant value index (INP) based on the values of Density, Frequency and Dominance. Data were collected using the plotted path method. The results showed that the density of sugar palm seedlings was very large, with an average of 13,055 seedlings/Ha (INP: 200%), the average pole density was 217 stems/Ha and the tree level averaged 90 trees/Ha. The number of panicles, which is the part that is used as raw material for making brown sugar, amounts to an average of 90 panicles/ha.
KEMAMPUAN TANAMAN GENJER (LIMNOCHARIS FLAVA) DALAM MENURUNKAN KADAR LOGAM BERAT TIMBAL PADA AIR LIMBAH ARTIFISIAL
Authors: Lidiana Roci , Suprayogi Dedy , Nengse Sulistiya 
Published: April 2022

Penelitian ini bertujuan untuk mengetahui kemampuan tanaman genjer dalam menurunkan kadar logam Pb pada air limbah. Penelitian ini dilaksanakan secara ekperimental menggunakan Rancangan Acak Lengkap (RAK) dengan menggunakan dua faktor variasi, yaitu jumlah tanaman (5, 10, dan 15 tanaman) dan waktu paparan (3, 5, dan 7 hari). Jenis reaktor fitoremediasi yang digunakan pada penelitian ini yaitu reaktor batch. Hasil penelitian menunjukan tanaman genjer mampu menurunkan logam Pb. Penurunan logam Pb yang paling efisien terjadi pada variasi 5 tanaman dengan lama paparan 7 hari yakni sebesar 0,06 ppm (99,6%). Namun, hasil penurunan tersebut belum memenuhi baku mutu air kelas 1 Peraturan Pemerintah Nomor 22 Tahun 2021 yaitu sebesar 0,03 ppm. Berdasarkan analisis statistik Kruskal-Wallis yang dilakukan, didapatkan P-value>0,05, atau tidak ada perbedaan nyata pada penggunaan variasi jumlah tanaman dan waktu paparan dalam menurunkan logam Pb. Kata Kunci: Air Limbah, Fitoremediasi, Logam Berat Timbal, Tanaman Genjer.This study aims to determine the capability of yellow velvetleaf to reduce the Pb levels in wastewater. The research is accomplished by doing an experiment that uses a Completely Randomized Design (CRD)with two variation factor, the number of plants (5, 10, and 15 plants) and exposure time (3, 5, and 7 days). The type of phytoremediation reactor used in this study is a batch reactor. The result showed that yellow velvetleaf were able to reduce Pb. The most efficient reduction of Pb levels occurs in the variation of 5 plants with exposure time for 7 days which is equal to 0,06 ppm (99,6%). However, the results of this reduction have not met the class 1 water quality standard of Peraturan Pemerintah Nomer 22 Tahun 2021, which is 0.03 ppm. Based on the Kruskal-Wallis statistical analysis, it was found that the P value> 0.05, or there was no significant difference in the use of variations in the number of plants and exposure time in reducing Pb. Keywords: Lead Heavy Metal, Phytoremediation, Wastewater, Yellow Velvetleaf.
Pergerakan Pasukan Divisi 7 Desember di Wilayah Jawa Barat (1947-1950)
Authors: Rifkialdy Muhammad Bintang , Darmawan Wawan , Winarti Murdiyah 
Published: April 2022

This article is entitled “The Movement of the 7 December Division Troops in the West Java Region (1947-1950)”. The main problem discussed in this article is how the movement of the 7 December Division Troops while in West Java. The purpose of this study is to examine more deeply the movement of the 7 December Division Troops in West Java during the battle with the TNI and the policies carried out by the 7 December Division while in West Java. This research used historical method which has several steps, namely Heuristic, source criticism in which there are external and internal criticisms, interpretation and historiography. To deepen the analysis of this research, this research used the approach of sociology and conflict theory. The research used literature study technique. Based on research results, the December 7th Division was a special troop formed directly by Queen Wilhelmina. These troops were asked to come to Indonesia and be stationed in the West Java region for the task of carrying out security and order. But the security and order carried out by the 7 December Division Troops in West Java constituted colonial order and security. West Java region is a strategic place because by conquering West Java, to control the capital can easily be achieved. The December 7th Division troops had their headquarters in the Batavia area. The 7 December Division troops have guardhouses in West Java, including: Buitenzorg, Batavia, Cibadak, Cianjur, Sukabumi, Tanggerang, Cibinong, Kebalen, and Tanjung Priok. In 1950, the 7 December Division was withdrawn and relieved of duties by Dutch East Indies. Keywords: 7 December Division Troops, West Java Region, Security and Order, Battle of West Java
Karakteristik Pasangan Usia Subur yang Menggunakan Metode Kontrasepsi Jangka Pendek di Kecamatan Banjarmasin Tengah
Authors: Hikmah Nurfiqria , Arisanty Deasy , Hastuti Karunia Puji 
Published: April 2022

This study aims to determine the demographic factors of short term contracepcion methods in fertile age couples in Banjarmasin Tengah District, Banjarmasin City, South Kalimantan Province in 2019. The research sample was fertile age couples who used short term contraception totaling 364 people. This study used descriptive research with a quantitative approach. Data collection was carried out using questionnaires, observations, interviews and studies of secondary data from related agencies. The sampling technique in the study used the Simple Random Sampling technique. Analyzing data in the study was descriptive analysis by percentage. The results showed that the fertile age couple in Banjarmasin who used short-term contraceptive methods were aged 20-35 years (61%), the number of children <2 (66%), high education level (66%), good contraception knowledge ( 100%), KIE from midwives (46%), family planning services from puskesmas (50%), and income according to the Banjarmasin UMR (58%). Keywords: Fertile age couple, short-term contraceptives, family planning, number of children
The Effect of Various Tricoderma sp. Isolate As TRICHOCOMPOST Fertilizer In Tomato (Lycopersicum esculentum Mill) Growth And Yield
Authors: Wachid Abdul , Fitrianisyah Laili 
Published: April 2022

The main objective of this investigation was to study the effects of TRICHOCOMPOST treatments on some vegetative growth and yield characters of tomato plants. This experiment was conducted at theyard area of Wates, Kedensari Village, Tanggulangin and Agricultural Research and Experiment Center, Muhammadiyah Sidoarjo University, during Februaryto August 2018. This research used a single factor Randomized Complete Block Design (RCBD) with compost fertilizer without Trichoderma sp. as control, Trichoderma sp. Claket isolate, Trichoderma sp. Jatijejer Isolate, dan Trichoderma sp. Jatirejo isolate as the main factor, 8 treatment levels and repeated 4 times. Then differences in the average value proceed used Honestly Significant Difference (HSD) at 5% level. The obtained results indicated generally that the effects of Trichocompost with Jatirejo isolate (P3) treatments reflected significant differences among the mean values of number of leaves plantand number of branch plant characters. Trichocompost with Jatijejer isolate (P2) reflected significant differences amongroot wet weight, Trichocompost with Jatirejo isolate (P3) reflected insignificant difference on plant characters than P0 treatment, however the treatment has the highhest mean value among the number of flower, the sum of fruit, and plant dry weight.
Designing and Study of New Small Molecules Based Thiophene as Donor Materials for Bulk Heterojunction Photovoltaic Cells
Authors: zouitina Said , Aboulouard Abdelkhalk , Ghazali Ahlam El , Byadi Said , idrissi Mohammed El , Tounsi Abdessamad 
Published: April 2022

Abstract
In this research work, we study the structural, optical, electronic and photovoltaic properties of eight thiophene-based π-conjugated organic molecules using quantum methods namely time-dependent density functional theory(TD-DFT). In particular, we identify the relationships between the chemical structure of these π-conjugated organic molecules and their optoelectronic properties. Moreover, we calculate and compare the highest energy occupied molecular orbital (HOMO) and lowest energy unoccupied molecular orbital (LUMO) energy levels of these compounds to that of the PCBM.As a result, the investigated molecules show a low band gap, suitable open circuit voltage and appropriate alignment energy level between the engineered donor molecules and the acceptor PCBM. This theoretical study shows that these new molecules have potential properties for the development of organic heterojunction photovoltaic cells.
Novel lectin-based chimeric antigen receptors target Gb3-positive tumour cells
Authors: Römer Winfried , Meléndez Ana Valeria , Cárdenas Rubí M-H Velasco , Lagies Simon , Siukstaite Lina , Thomas Oliver S. , Weber Wilfried , Kammerer Bernd , Minguet Susana 
Published: April 2022

Abstract
A link between cancer and aberrant glycosylation has recently become evident. Glycans and their altered forms, known as tumour-associated carbohydrate antigens (TACAs), are diverse, complex and difficult to target therapeutically. Lectins are naturally occurring glycan-binding proteins and offer a unique opportunity to recognise TACAs. T cells expressing chimeric antigen receptors (CARs) have proven to be a successful immunotherapy against leukaemias, but so far have shown limited success in solid tumours. We developed a panel of lectin-CARs that recognise the glycosphingolipid globotriaosylceramide (Gb3), which is overexpressed in various cancers, such as Burkitt's lymphoma, colorectal, breast and pancreatic cancer. We have selected the following lectins: Shiga toxin's B-subunit from Shigella dysenteriae , LecA from Pseudomonas aeruginosa , and the engineered lectin Mitsuba from Mytilus galloprovincialis as antigen-binding domains and fused them to a well-known second generation CAR. The Gb3-binding lectin-CARs have demonstrated target-specific cytotoxicity against Burkitt's lymphoma-derived cell lines as well as solid tumour cells from colorectal and triple negative breast cancer. Our findings reveal the big potential of lectin-based CARs as therapeutical applications to target Gb3 and other TACAs expressed in haematological malignancies and solid tumours.