bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Concept of Retrofitting Suburban in Commercial Corridor
Authors: Sitompul Sonia Nadia Ruth Madelene , Hadinugroho Dwi Lindarto 
Published: October 2022

Pasar Ikan Lama, located on the Commercial Road, is a well-known commercial area in Medan. The location is close to the city center so that local and foreign tourists easily find it. The place dominates by cloth sales such as kebaya wholesaler center, headscarves, Mukenah, prayer mats, carpets, batik, traditional clothing, and their items are originating from Makah such as dates and zam-zam water. The phenomenon that is now occurring in the Pasar Ikan Lama is an untidy arrangement. Another phenomenon is the strategic position that is adjacent to the historical area. Even so, the Pasar Ikan Lama is still visited. Visitors come not only from Medan but from various regions to foreign countries. The Pasar Ikan Lama can use as a destination or icon for the City of Medan. Therefore, it is necessary to revitalize it to increase vitality in the area of ​​the Pasar Ikan Lama. Revitalization model for the Medan commercial corridor with the concept of suburban retrofitting carried out using the theory of Suburban Retrofitting as a basis, accordingly the idea of Hamid Shirvani as a determinant of needs from a commercial corridor, Lynch theory is beneficial as a determinant of something interesting, potentially to be developed or abolished. The results of the study obtained from this study are the revitalization model of the Medan City commercial corridor with the concept of suburban retrofitting
, textiles y saberes de las mujeres wixaritari
Authors: Pacheco Ladrón de Guevara Lourdes Consuelo 
Published: October 2022

En el presente texto me propongo abordar los textiles de las mujeres wixaritari[1] como saberes de las mujeres indígenas, dentro de una concepción que considera los textiles como expresión de la experiencia de las mujeres, en los que capturan/rehacen formas de la naturaleza en trazos, formas, dimensiones y colores.

El texto se centra en dos aspectos: el primero se refiere a problematizar lo que se entiende por arte/artesanía y el segundo, a abordar la creación de textiles como una forma de expresión textilizada del entorno vivido y simbolizado, que no es ficcional en el sentido de narrar, desde la imaginación o la utopía, sino desde maneras decantadas de estar en el mundo y que surgen en el acontecer de la experiencia de vida de las mujeres wixaritari. Lo que propongo es comprender los textiles como una escritura de saberes donde las mujeres participan con sus cuerpos y sus experiencias de vida dentro de las comunidades.

[1] El pueblo wixaritari o huicholes, habitan una extensa zona comprendida en los Estados de Nayarit, Jalisco y Zacatecas. Además de tener presencia en algunas zonas urbanas.
La labor del docente dentro del Espacio Europeo de Educación Superior y de la sociedad de los Objetivos de Desarrollo Sostenible
Authors: García Moro Francisco José , Gomez Baya Diego , Augusto Nicoletti Javier 
Published: October 2022

La sociedad actual, tan global y tal local al mismo tiempo, gira en torno a múltiples fuerzas, muchas de ellas contradictorias, que exigen respuestas en el ahora inmediato pero también sin olvidar el futuro. La universidad no es ajena a dicha situación; y ya no le basta con transmitir conocimientos, y menos información; sino que ha de asumir una función ontológicamente propedéutica, ética, de capacitación y preparación, para que el futuro profesional tenga la competencia de identificar lo que acerca a la persona, a la sociedad y al mundo al bien, sabiendo diferenciar lo importante de lo que no lo es; el discurso que narcotiza de la orientación que apoya y media. Ya no es suficiente con saber hacer, sino que el buen hacer y el buen ser cobran especial protagonismo. El presente artículo es una reflexión de lo que la universidad, y más concretamente, la función docente en la educación superior, debería de aportar a los futuros profesionales con una finalidad más enfocada en la persona y sociedad. En particular, se indaga en el concepto de pensamiento crítico y en aquellas estrategias que se pueden utilizar en la enseñanza superior para favorecerlo.
Clinical characteristics and analysis of risk factors for disease progression of patients with SARS-CoV-2 Omicron variant infection: A retrospective study of 25207 cases in a Fangcang hospital
Authors: Ying-hao Pei , Yuan-yuan Gu , Hai-dong Zhang , Qiu-hua Chen , Xue-ran Gu , Hai-qi Zhou , Hua Jiang 
Published: October 2022

ObjectivesTo summarize the clinical characteristics of patients infected by SARS-CoV-2 omicron variant and explore the risk factors affecting the progression in a Fangcang hospital, Shanghai, China.MethodsA total of 25,207 patients were retrospectively enrolled. We described the clinical characteristics and performed univariate and multivariate logistic regression analysis to identify the risk factors for non-severe to severe COVID-19 or death.ResultsAccording to the outcomes, there were 39 severe patients (including 1 death) and 25,168 non-severe patients enrolled in this study. Among the 25,207 cases, the median age was 45 years (IQR 33-54), and 65% patients were male. Cough (44.5%) and expectoration (38.4%) were the most two common symptoms. Hypertension (10.4%) and diabetes (3.5%) were most two common comorbidities. Most patients (81.1%) were fully vaccinated. The unvaccinated and partially vaccinated patients were 15.1% and 3.9%, respectively. The length of viral shedding time was six days (IQR 4-9) in non-severe patients. Multivariate logistic regression analysis suggested that age (OR=1.062, 95%CI 1.034-1.090, p&lt;0.001), fever (OR=2.603, 95%CI 1.061-6.384, p=0.037), cough (OR=0.276, 95%CI 0.119-0.637, p=0.003), fatigue (OR=4.677, 95%CI 1.976-11.068, p&lt;0.001), taste disorders (OR=14.917, 95%CI 1.884-118.095, p=0.010), and comorbidity (OR=2.134, 95%CI 1.059-4.302, p=0.034) were predictive factors for deterioration of SARS-CoV-2 omicron variant infection.ConclusionsNon-critical patients have different clinical characteristics from critical patients. Age, fever, cough, fatigue, taste disorders, and comorbidity are predictors for the deterioration of SARS-CoV-2 omicron variant infection.
Differences in the impact of impaired glucose status on clinical outcomes in younger and older adults: Over a decade of follow-up in the Tehran lipid and glucose study
Authors: Asgari Samaneh , Masrouri Soroush , Khalili Davood , Azizi Fereidoun , Hadaegh Farzad 
Published: October 2022

IntroductionStudies found that the impact of dysglycemia on microvascular, macrovascular events and mortality outcomes were different between the younger vs. older population. We aimed to investigate the age-specific association of prediabetes with clinical outcomes including type 2 diabetes (T2DM), hypertension, chronic kidney disease (CKD), cardiovascular disease (CVD), and mortality.Materials and methodsA total of 5,970 Iranians (3,829 women) aged ≥30 years, without T2DM, were included. The age-specific (&lt;60 and ≥60 years; minimum p-value for interaction = 0.001) multivariable-adjusted Cox regression was done to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) of the impaired glucose status including impaired fasting glucose (IFG) vs. normal fasting glucose (NFG), impaired glucose tolerance (IGT) vs. normal glucose tolerance (NGT), and IFG&amp;IGT vs. NFG/NGT with each outcome.ResultsAmong individuals aged ≥60 years, the prevalence of impaired glucose status (IFG, IGT, or both) was about 2 times higher compared to those aged &lt;60. Age-specific association between prediabetes and incident hypertension was found for those aged &lt;60 years; [HR (95% CI); IFG: 1.38 (1.16–1.65), IGT: 1.51 (1.26–1.81), and IFG&amp;IGT: 1.62 (1.21–2.12)]. For CVD, in all impaired glycemic states, those aged &lt;60 were at higher significant risk [IFG: 1.39 (1.09–1.77), IGT: 1.53 (1.19–1.97), and IFG&amp;IGT: 1.60 (1.14–2.25)]. Stratified analyses showed similar associations for IFG and IGT with non-CV mortality 1.71 (1.04–2.80) and 2.12 (1.30–3.46), respectively, and for all-cause mortality among those aged &lt;60 years [IFG: 1.63 (1.08–2.45) and IGT: 1.82 (1.20–2.76)]. In both age groups, all glycemic status groups were significantly associated with T2DM but not with CKD and CV mortality.ConclusionsThe high prevalence of prediabetes particularly among the elderly population, limited resources, and the observed significant age differences in the impact of prediabetes states on different clinical outcomes calls for multicomponent intervention strategies by policy health makers, including lifestyle and possible pharmacological therapy, with the priority for the young Iranian population.
Percutaneous or mini-invasive surgical radiofrequency re-ablation of atrial fibrillation: Impact on atrial function and echocardiographic predictors of short and long-term success
Authors: Montserrat Sílvia , Gabrielli Luigi , Borràs Roger , Cascos Enric , Castellá Manel , Sanchis Laura , Bijnens Bart , Mont Lluís , Sitges Marta 
Published: October 2022

ObjectivesThe aim of this study was to compare percutaneous catheter ablation vs. minimally invasive surgical ablation, evaluating the impact of repeated ablation on atrial function, and evaluating predictors of atrial fibrillation (AF) recurrence.BackgroundWhen AF ablation fails, re-ablations are required in up to 40% of patients to treat recurrent arrhythmia; surgical ablation is more effective than catheter ablation.MethodsThirty-two patients with failed prior catheter ablation and referred for a second ablation (18 catheter and 14 surgical) were included in a descriptive observational study. Left atrial volumes, strain, and strain rate were measured with 2D speckle tracking echocardiography at baseline and 6 months after the procedures to assess left atrial functions. Patients received up to 1 year of clinical and Holter follow-up.ResultsAt the 12-month follow-up, catheter ablation was effective in 56% and surgical ablation in 72% of patients (OR 2 (CI 0.45–8.84), p 0.36). Left atrial booster function was similar in all patients, but left atrial reservoir function was more impaired in those patients who underwent surgical ablation. Left atrial booster function was predictive of arrhythmia recurrence after both catheter and surgical ablation: late diastolic strain rate (LASRa) cut-off ≤ -0.89 s–1 (sensitivity 88%, specificity 70%, AUC 0.82) and ≤ -0.85 s–1 (sensitivity 60%, specificity 100%, AUC 0.82), respectively.ConclusionSurgical ablation has a more negative impact on LA reservoir function despite being slightly more effective in arrhythmia suppression. LA booster function is not significantly impaired by either procedure. LA booster function predicts arrhythmia elimination after a re-ablation (catheter or surgical).
Systematic bibliometric and visualized analysis of research hotspots and trends on the application of artificial intelligence in diabetic retinopathy
Authors: Wang Ruoyu , Zuo Guangxi , Li Kunke , Li Wangting , Xuan Zhiqiang , Han Yongzhao , Yang Weihua 
Published: October 2022

BackgroundArtificial intelligence (AI), which has been used to diagnose diabetic retinopathy (DR), may impact future medical and ophthalmic practices. Therefore, this study explored AI’s general applications and research frontiers in the detection and gradation of DR.MethodsCitation data were obtained from the Web of Science Core Collection database (WoSCC) to assess the application of AI in diagnosing DR in the literature published from January 1, 2012, to June 30, 2022. These data were processed by CiteSpace 6.1.R3 software.ResultsOverall, 858 publications from 77 countries and regions were examined, with the United States considered the leading country in this domain. The largest cluster labeled “automated detection” was employed in the generating stage from 2007 to 2014. The burst keywords from 2020 to 2022 were artificial intelligence and transfer learning.ConclusionInitial research focused on the study of intelligent algorithms used to localize or recognize lesions on fundus images to assist in diagnosing DR. Presently, the focus of research has changed from upgrading the accuracy and efficiency of DR lesion detection and classification to research on DR diagnostic systems. However, further studies on DR and computer engineering are required.
Triglyceride: A mediator of the association between waist-to-height ratio and non-alcoholic fatty liver disease: A second analysis of a population-based study
Authors: Hu Haofei , Han Yong , Liu Yufei , Guan Mijie , Wan Qijun 
Published: October 2022

ObjectiveIncreasing evidence suggests that an increased waist-to-height ratio (WHtR) may increase the risk of non-alcoholic fatty liver disease (NAFLD). Whether this association is due to WHtR itself or mediated by WHtR-associated increases in triglyceride (TG) is uncertain. On that account, our research aims to disentangle these relationships.MethodsIn this cross-sectional study, 14251 participants who participated in the medical examination program were consecutively and non-selectively collected in Murakami Memorial Hospital in Japan from 2004 to 2015. The independent and dependent variables were WHtR and NAFLD, respectively. Triglyceride was the mediating factor. The correlation between WHtR, TG, and NAFLD risk factors was examined using spearman correlation analysis. The association between WHtR or TG and NAFLD was examined using multiple logistic regression. In order to determine whether TG mediated the association between WHtR and NAFLD, a mediation analysis was performed.ResultsThe mean age of the included individuals was 43.53 ± 8.89 years old, and 7411 (52.00%) were male. The mean WHtR and TG were 0.46 ± 0.05, 0.89 ± 0.63, respectively. The prevalence rate of NAFLD was 2507 (17.59%). Individuals with NAFLD had significantly higher levels of WHtR and TG than those without NAFLD (P&lt;0.05). After adjusting covariates, the multivariate linear regression analysis showed that WHtR was positively associated with TG. That was, for every 0.1 increase in WHtR, TG increased by 0.226mmol/L (β=0.226, 95%CI: 0.206, 0.247). Multiple logistic regression analysis indicated that WHtR (OR=8.743, 95%CI: 7.528, 10.153) and TG (OR=1.897, 95%CI: 1.732, 2.078) were positively associated with NAFLD. The mediation analysis showed that WHtR had a direct, significant effect on NAFLD (β=0.139, 95%CI: 0.126, 0.148), and TG partially mediated the indirect effect of WHtR on NAFLD (β=0.016, 95% CI: 0.013-0.019). TG contributed to 10.41% of WHtR-related NAFLD development.ConclusionFindings suggest a mediation link between WHtR and TG and the risk of NAFLD. The significance of TG as a mediator deserves recognition and consideration.
An artificial intelligence ultrasound system’s ability to distinguish benign from malignant follicular-patterned lesions
Authors: Xu Dong , Wang Yuan , Wu Hao , Lu Wenliang , Chang Wanru , Yao Jincao , Yan Meiying , Peng Chanjuan , Yang Chen , Wang Liping , Xu Lei 
Published: October 2022

ObjectivesTo evaluate the application value of a generally trained artificial intelligence (AI) automatic diagnosis system in the malignancy diagnosis of follicular-patterned thyroid lesions (FPTL), including follicular thyroid carcinoma (FTC), adenomatoid hyperplasia nodule (AHN) and follicular thyroid adenoma (FTA) and compare the diagnostic performance with radiologists of different experience levels.MethodsWe retrospectively reviewed 607 patients with 699 thyroid nodules that included 168 malignant nodules by using postoperative pathology as the gold standard, and compared the diagnostic performances of three radiologists (one junior, two senior) and that of AI automatic diagnosis system in malignancy diagnosis of FPTL in terms of sensitivity, specificity and accuracy, respectively. Pairwise t-test was used to evaluate the statistically significant difference.ResultsThe accuracy of the AI system in malignancy diagnosis was 0.71, which was higher than the best radiologist in this study by a margin of 0.09 with a p-value of 2.08×10-5. Two radiologists had higher sensitivity (0.84 and 0.78) than that of the AI system (0.69) at the cost of having much lower specificity (0.35, 0.57 versus 0.71). One senior radiologist showed balanced sensitivity and specificity (0.62 and 0.54) but both were lower than that of the AI system.ConclusionsThe generally trained AI automatic diagnosis system can potentially assist radiologists for distinguishing FTC from other FPTL cases that share poorly distinguishable ultrasonographical features.
Case report: Prenatal diagnosis of Ectrodactyly–Ectodermal dysplasia–Cleft syndrome (EEC) in a fetus with cleft lip and polycystic kidney
Authors: Biwei He , Min Su , Yanlin Wang , Xinrong Zhao , Li Gao , Renyi Hua , Jinling Sun , Shan Wang , Yi Wu , Weiwei Cheng 
Published: October 2022

Ectrodactyly–ectodermal dysplasia–cleft (EEC) syndrome is an autosomal dominant disorder characterized by ectrodactyly, ectodermal dysplasia, and orofacial clefting. Reduced penetrance is manifested in these core features and additional under-recognized features, especially in prenatal cases. Here, we present a fetus with EEC syndrome at 22 weeks gestation, in which the cleft lip and palate and the right polycystic kidney are shown by prenatal ultrasound. A de novo missense mutation of R304W in the TP63 gene is confirmed by whole-exome sequencing associated with EEC syndrome. We further investigate the reported TP63-related prenatal cases and provide a more complete picture of the prenatal phenotypic spectrum about EEC. It illustrates the potential severity of genitourinary anomalies in TP63-related disorders and highlights the need to counsel for the possibility of EEC syndrome, given the occurrence of genitourinary anomalies with orofacial cleft or limb deformities.
Polymorphisms of nucleotide excision repair genes associated with colorectal cancer risk: Meta-analysis and trial sequential analysis
Authors: Yi Chuncheng , Li Tiandong , Shen Yajing , Wang Peng , Dai Liping , Shi Jianxiang , Wang Keyan , Sun Changqing , Ye Hua 
Published: October 2022

Background: Reduced DNA repair capacity in nucleotide excision repair (NER) pathways owing to genetic variant may influence cancer susceptibility. According to published studies, variants of NER genes associations with colorectal cancer (CRC) risk were inconclusive. Thus, this meta-analysis aimed to explore the possible association. A trial sequence analysis (TSA) analysis was performed to control the risk of false positive or false negative.Methods: PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Network (CNKI), Wanfang Database and Scientific and Technical Journal Database (VIP) were searched to identify relative studies until April 2022. The association was assessed by odds ratio (OR) in Allele, homozygous, heterozygous, dominant, recessive, and over-dominant models. In addition, Begg’s and Egger’s tests, sensitivity analysis, subgroup analysis and TSA analysis were performed.Results: A total of 29 studies were eventually included in the meta-analysis, including 12,153 CRC patients and 14,168 controls. It showed that excision and repair cross complementary group 1 (ERCC1) rs11615 CC genotype decreased the risk of CRC, compared with TT genotype (CC vs. TT: OR = 0.816, 95% CI = 0.673–0.990, p = 0.039). For ERCC1 rs3212986, the significant impact was detected on increased the risk of CRC in the allele (OR = 1.267, 95% CI = 1.027–1.562, p = 0.027), homozygous (OR = 1.805, 95% CI = 1.276–2.553, p = 0.001), dominant (OR = 1.214, 95% CI = 1.012–1.455, p = 0.037) and recessive (OR = 1.714, 95% CI = 1.225–2.399, p = 0.002) models, especially in the Asian population. The results revealed the association of ERCC2 rs1799793 A allele with a higher risk of CRC (A vs. G: OR = 1.163, 95% CI = 1.021–1.325, p = 0.023). It also showed that ERCC5 rs17655 increased CRC risk in the allele (OR = 1.104, 95% CI = 1.039–1.173, p = 0.001), homozygous (OR = 1.164, 95% CI = 1.018–1.329, p = 0.026), heterozygous (OR = 1.271, 95% CI = 1.018–1.329, p &lt; 0.001), dominant (OR = 1.241, 95% CI = 1.135–1.358, p &lt; 0.001) and over-dominant (OR = 0.828, 95% CI = 0.762–0.900, p &lt; 0.001) models, especially among Asians.Conclusion: This meta-analysis based on current evidence suggests that the significant association was observed between ERCC1 rs11615, ERCC1 rs3212986, ERCC2 rs1799793, and ERCC5 rs17655 and CRC susceptibility. However, given the limited sample size and the influence of genetic background, studies of a larger scale and well-designed are required to confirm the results.
Case Report: Variegate porphyria disclosed by post-gastric bypass complications and causing predominant painful sensorimotor axonal peripheral neuropathy
Authors: Collaud Edwige , Wittwer Luis , Minder Anna-Elisabeth , Annoni Jean-Marie , Minder Elisabeth I. , Chabwine Joelle N. 
Published: October 2022

Background and aims: Porphyrias constitute a group of rare genetic diseases due to various, mostly autosomal dominant mutations, causing enzymatic deficiency in heme biosynthesis. As a result, neurotoxic porphyrin precursors and light-sensitive porphyrins accumulate, while dysfunction in their targets determines the disease symptoms. Variegate porphyria (VP), one of the acute hepatic porphyrias, is caused by a protoporphyrinogen oxidase (PPOX) mutation. During acute attacks, among other factors, triggered by drugs, stressors, or fasting, an increase in urinary and fecal porphobilinogen (PBG), aminolevulinic acid (ALA), and porphyrins occurs, damaging the autonomous, peripheral, or central nervous system. The disease remains often latent or displays minimal symptoms usually overlooked, exposing undiagnosed patients to potentially serious complications in the presence of the aforementioned triggers.Case report: This 46-year-old woman presented, some days after a bariatric surgery, with severe flaccid tetraparesis and neuropathic pain, initially misdiagnosed as a functional neurological disorder. The severe axonal sensorimotor polyneuropathy led to further investigations, disclosing high urinary porphobilinogen, ALA, and porphyrin levels due to a new PPOX mutation. Retrospectively, it appeared that the patient had had typical VP symptoms (abdominal pain, fragile skin, and dark urine episodes) for years prior to the surgery. Treated with carbohydrate load, neurorehabilitation, and analgesics, she slowly recovered to full mobility, with partial autonomy in her daily life activities, although fatigue and severe pain persisted, preventing her from returning to work.Conclusion: This case documents gastric bypass surgery as a trigger of severe VP invalidating neurological symptoms and illustrates how the delayed diagnosis and post-interventional complications could have been prevented by screening for porphyria cardinal symptoms prior to the intervention. Likewise, this cost-effective screening should be performed before any treatment influencing the diet, which would dramatically improve the porphyria diagnosis rate and outcome.