bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful treatment of advanced squamous cell carcinoma arising from mature cystic teratoma of the ovary with homologous recombination deficiency: A case report
Authors: Tamura Ryo , Yamaguchi Masayuki , Kitani Yohei , Nishikawa Nobumichi , Kawasaki Takashi , Kikuchi Akira 
Published: June 2022

Abstract
BackgroundSquamous cell carcinoma arising from mature cystic teratoma of the ovary (MCT-SCC) has a poor prognosis at advanced stages. Although the relationship between the homologous recombination deficiency (HRD) status and platinum-based chemotherapy sensitivity or poly (ADP ribose) polymerase (PARP) inhibitor efficacy in epithelial ovarian cancer has been demonstrated in clinical trials, the significance of the HRD status in MCT-SCC remains unclear.Case presentationA 73-year-old woman with no remarkable past medical history was referred to our hospital for a huge left ovarian tumor. Laparotomy was urgently performed due to tumor rupture. We performed total abdominal hysterectomy, bilateral salpingo-oophorectomy, and partial omentectomy. The ovarian tumor was strongly adherent to the surrounding pelvic organs and could not be completely resected. The postoperative diagnosis was stage IIIB MCT-SCC (pT3bNXM0) of the left ovary. After surgery, we conducted the myChoice CDx and microsatellite instability (MSI) tests. The genomic instability (GI) score of 87 was remarkably high, and there was no BRCA1/2 pathogenic mutation. In contrast, the MSI test was negative. After six courses of combination therapy with paclitaxel and carboplatin, the residual tumors had shrunk by 73% (target lesions: 85 mm to 23 mm) and SCC-Antigen levels decreased from 12.8 ng/ml postoperatively to 1.6 ng/ml at the end of the initial course of chemotherapy and remained in the normal range thereafter. We considered the complete removal of residual tumors feasible and performed interval debulking surgery (IDS). We performed residual tumor resection and pelvic and para-aortic lymphadenectomy, and the tumors were completely resected. Subsequently, the patient underwent two courses of the combination of paclitaxel, carboplatin, and bevacizumab, followed by maintenance therapy with olaparib and bevacizumab. Five months after IDS, no recurrence has been observed.Conclusion To the best of our knowledge, this is the first reported case of MCT-SCC with HRD-positive status. Although its frequency is unknown, platinum-based chemotherapy followed by maintenance therapy with oraparib and bevacizumab could be one of the promising treatment options for MCT-SCC.
How Priming with Body Odors Affects Consumer Behavior
Authors: Alcaniz Mariano , Giglioli Irene Irene Alice Chicchi , Carrasco-Ribelles Lucia A. , Minissi Maria Maria Eleonora , Semin Gün 
Published: June 2022

Abstract
To date, odor research has primarily focused on the behavioral effects of common odors on consumer perception and choices. We report a study that examines, for the first time, the effects of human body odor cues on consumer purchase behaviors. The influence of human chemosignals produced in three conditions, namely happiness, fear, a relaxed condition (rest), and a control condition (no odor), were examined on willingness to pay (WTP) judgments across various products. We focused on the speed with which participants reached such decisions. The central finding revealed that participants exposed to human odors reached decisions significantly faster than the no odor control group. The main driving force is that human body odors activate the presence of others during decision-making. This, in turn, affects response speed. The broader implications of this finding for consumer behavior are discussed.
Theory-based mHealth targeting fathers and mothers to improv exclusive breastfeeding: a quasi-experimental study
Authors: Gebremariam Kidane , Mulugeta Afework , Gallegos Danielle 
Published: June 2022

Abstract
BackgroundExclusive breastfeeding remains sub-optimal in low-income countries contributing to infant mortality. mHealth interventions to improve exclusive breastfeeding have shown promise, but very few include fathers or have been applied in low-income countries. The aim of this study was to assess the effectiveness of a SMS-based breastfeeding intervention targeting fathers and mothers in improving exclusive breastfeeding at three months in a low-income country.MethodsA quasi-experimental study was carried out with couples in their last trimester of pregnancy, in Mekelle, Ethiopia. The SMS-based intervention delivered a total of 16 SMS text messages to two arms: mothers-and-fathers, and mothers-only with the third group acting as the control. The main outcome measure was exclusive breastfeeding at months one, two and three after birth.Result There were no significant differences in exclusive breastfeeding at month one between the three groups (N=128). At month three 85% and 80% of babies were exclusively breastfed in the mothers-and-fathers and the mothers-only compared to 60% in the control group (p=0.01, p=0.04). Babies born to mothers in the mother-and-fathers group were almost five times more likely to be exclusively breastfeed at three months than babies born to mothers who received standard care [AOR: 4.88, 95% CI (1.35-17.63)]. Conclusion An mHealth intervention targeting fathers and mothers, and mothers increased the likelihood of babies being exclusively breastfed at three months. The risk of not exclusively breastfeeding in the control group increased over time. A low-cost SMS-based breastfeeding intervention targeting fathers and mothers significantly improved exclusive breastfeeding.Trial registration: This trial was registered with the Australian New Zealand Clinical Trials Registry (ANZCTR) 12618001481268.
A comprehensive study on the scavenging of carcinogenic metal ions using immobilized microalgae Auxenochlorella protothecoides on the lignocellulosic matrix
Authors: NOUACER Imane , HAMMADI Soumia , BENALIA Mokhtar , DJEDID Mebrouk , BENCHEIKH Salah Eddine 
Published: June 2022

Abstract
An efficient carcinogenic metal biosorbent was prepared by immobilizing microalgae Auxenochlorella protothecoides (AP) within Sugarcane Bagasse (SB) lignocellulosic matrix. The immobilization technique enhanced the biosorption of nickel by 32.25% at equilibrium compared with free Auxenochlorella protothecoides. The maximum metal biosorption capacity of free and immobilized Auxenochlorella protothecoides was calculated to be 42.08 and 62.1 mg /g, respectively. The removal efficiency of nickel ions was evaluated with Box-Behnken factorial design using three parameters: pH solution, contact time, and biosorbent concentration. Under optimum conditions, the RSM- DF platform determined the maximum metal elimination rate of 97.96% with the following optimal set of factors: pH 5.06, biosorbent concentration of 1.6 g/L, and contact time of 53.33 min. In the experimental design of the nickel bioprocess, the equilibrium adsorption isotherms were analyzed using sixteen models of two-, three-, and four –parameters. An evaluation of non-linear regression isotherms for choosing the goodness predicted fit elucidated that Fritz–Schlünder (IV) model was the more suitable model to present the equilibrium curves, identified based on the values of four error functions were as follow: the coefficient of determination (R²), the hybrid fractional error function (HYBRID), marquardt's percent standard deviation (MPSD), and the average relative error (ARE). The thermodynamic factors followed by the kinetics analyze demonstrated that the bioprocess was exothermic, favorable, and spontaneous at 298–318 K. Further, the biosorption of nickel ions towards the functional sites on the SB-AP was clarified by the proposal of four mechanisms on the network structure for cellulose, lignin, N-acetyl- β -d-glucosamine, and β-D-glucosamine unite. Finally, the functional groups, surface morphology, elemental compositions was analyzed using FTIR, SEM-EDX and ATG-DTG, respectively confirmed its ability to successfully treating the contaminants.
Associations between Dietary and Plasma Copper and Liver Function in a Chinese Population
Authors: Wei Yanfei , Zhang Zhiyong , Mo Xiaoting , Xu Min , Liu Qiumei , Zhang Junling , Liu Shuzhen , Lin Yinxia , Huang Shenxiang , Qin Jian , Cai Jiansheng 
Published: June 2022

Abstract
The potential mechanisms underlying the association between copper exposure and liver function are unclear. This study aimed to investigate the potential association of dietary copper (Cu) intake and plasma Cu with liver function parameters. A cross-sectional study was performed to determine liver function parameters—namely, total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), alanine transaminase (ALT), and aspartate transaminase (AST)—in 2376 subjects in Guangxi, China. Dietary Cu was obtained from a food frequency questionnaire containing 109 common foods. Plasma Cu concentrations were determined by inductively coupled plasma mass spectrometry. Multiple linear regression combined with the multivariate restricted cubic spline function (RCS) was used to evaluate the correlation of plasma and dietary Cu with liver function parameters. The covariate adjustment results of the linear regression analysis showed that plasma Cu levels were significantly negatively correlated with serum IBIL (β = −0.37), DBIL (β = −0.22), and TBIL (β = −0.32) (all p < 0.05), and dietary Cu was negatively correlated with serum AST (β = −0.12, p < 0.05). The spline analysis further elucidated the negative linear relationship between dietary Cu and AST in the total population. In summary, our results suggested that plasma Cu is associated with serum bilirubin and dietary Cu is associated with serum AST. Further studies are needed to validate these associations and reveal the underlying mechanisms.
Management of Agricultural Waste Biomass as raw material for the construction sector. An analysis of sustainable and circular alternatives
Authors: Duque-Acevedo Mónica , Lancellotti Isabella , Andreola Fernanda , Barbieri Luisa , Belmonte-Ureña Luis J. , Camacho-Ferre Francisco 
Published: June 2022

Abstract
Background: The agricultural and construction sectors demand enormous amounts of natural resources and generate environmental impacts that negatively affect ecosystems. One of the main problems is the generation and inadequate management of waste. For this reason, under the approaches of the new sustainable and circular models, waste valorization has been prioritised as a strategy for advancing towards the sustainability of production systems. This research aims to carry out a general analysis of Agricultural Waste Biomass (AWB) in the production of bio-based products for the construction sector. Bibliometric techniques were applied for the general analysis of the scientific production obtained from Scopus. A systematic review identified the main research approaches. In addition, European projects were reviewed to assess the practical application. This study is novel and provides relevant contributions to new trends in the valorisation of AWB in the building sector and the sustainability benefits. For policymakers, it is a source of information on the contribution of new policies to scientific advances and the aspects that need to be strengthened to improve sustainable and circular practices in both sectors.Results: The results show that 74% of the research has been published within the last five years. Regarding the main types of AWBs, rice husk ash and sugar cane bagasse ash are the most commonly used in manufacturing a wide variety of bio-based building products. Cement, concrete and bricks are the main bio-based products obtained from AWB. However, a new approach to utilisation was identified in road construction. Conclusions: The findings indicate that the AWB is an important resource with great potential for the construction sector. Similarly, that policies on sustainable and circular development have driven scientific progress on new alternatives for the valorisation of AWB to improve sustainability in the construction sector. Although the practical application has also been driven through European projects, development at this level is still low. Therefore, it is necessary to strengthen partnerships between these two sectors and improve government strategies on sustainability and circularity to overcome existing constraints.
A novel Silva pattern-based model for precisely predicting recurrence in intermediate-risk cervical adenocarcinoma patients
Authors: Guo Chenyan , Tao Xiang , Zhang Lihong , Zhang Ying , Hua Keqin , Qiu Junjun 
Published: June 2022

Abstract
Background: Considering the unique biological behavior of cervical adenocarcinoma (AC) compared to squamous cell carcinoma, we now lack a distinct method to assess prognosis for AC patients, especially for intermediate-risk patients. Thus, we sought to establish a Silva-based model to predict recurrence specific for the intermediate-risk AC patients and guide adjuvant therapy.Methods: 345 AC patients were classified according to Silva pattern, their clinicopathological data and survival outcomes were assessed. Among them, 254 patients with only intermediate-risk factors were identified. The significant cutoff values of four factors (tumor size, lymphovascular space invasion (LVSI), depth of stromal invasion (DSI) and Silva pattern) were determined by univariate and multivariate Cox analyses. Subsequently, a series of four-, three- and two-factor Silva-based models were developed via various combinations of the above factors. Results: (1) We confirmed the prognostic value of Silva pattern using a cohort of 345 AC patients. (2) We established Silva-based models with potential recurrence prediction value in 254 intermediate-risk AC patients, including 12 four-factor models, 30 three-factor models and 16 two-factor models. (3) Notably, the four-factor model, which includes any three of four intermediate-risk factors (Silva C, ≥3 cm, DSI >2/3, and >mild LVSI), exhibited the best recurrence prediction performance and surpassed the Sedlis criteria. Conclusions: Our study established a Silva-based four-factor model specific for intermediate-risk AC patients, which has superior recurrence prediction performance than Sedlis criteria and may better guide postoperative adjuvant therapy.
Survival Analysis and Risk Factors for in-hospital mortality in COVID-19 Patients: A retrospective cohort study
Authors: Hosseini Elahe Seyed , Azadchehr Mohammd-Javad , Sarafrazi Mahla , Vaghari Leila , Parchebafi Atefeh , Nikzad Hossein , Kashani Hamed Haddad 
Published: June 2022

Abstract
Purpose:
Since the outbreak in late December 2019 in Wuhan, China, coronavirus disease-2019 (COVID-19) has become a global pandemic. We analyzed and compared the clinical, laboratory, and radiological characteristics between survivors and non-survivors and identify risk factors for mortality.
Methods:
This single-center study was conducted at Hospital for COVID-19 patients in Kashan, Iran. Inpatients with confirmed COVID-19 were included. Clinical and laboratory variables, radiological features, complications were collected. Patients were classified as the discharged or survivor group and the death or non-survivor group based on their outcome (improvement or death). Clinical, Epidemiological characteristics, as well as laboratory parameters, were extracted from electronic medical records. Cox regression analysis was conducted to identify the risk factors for mortality. Significant level was set as 0.05 in all analyses.
Results:
Multiple Cox regression showed age (HR 1.028; 95% CI 1.016–1.039), LDH (HR 1.0004; 95% CI 1.0002–1.001), AST (HR 1.002; 95% CI 1.001–1.004) and BUN (HR 1.008; 95% CI 1.004–1.012) as factors associated with an increased risk of in-hospital mortality.
Conclusion:
The current study showed that higher mortality was significantly associated with age, LDH, AST and BUN. Assessing risk factors of the disease could be helpful for clinicians to detect the risk of disease progression, to perform proper intervention earlier to get the best therapeutic outcome.
Effect of Quercetin on Tumor-Derived Exosomal miRNA Circulation in Primary (Colo 320) and Metastatic (Colo 741) Colon Cancer Cell Lines
Authors: Becer Eda , Özsoy Serpil , Kabadayı Hilal , Vatansever Hafize Seda 
Published: June 2022

Abstract
Objective: Quercetin is a phytochemical that is regarded as a potential anticancer agent in colon cancer prevention. Exosomes are nanovesicles secreted by normal or cancer cells, which transport miRNAs and proteins and participate in intercellular communication as a cargo. Cytotoxicity, exosomal miRNA secretion, and distribution of Dicer, Ago2, CD9, CD63 and eIF2α in quercetin applied Colo 320 and Colo 741 colon cancer cell lines were aimed.Materials and Methods: The cytotoxicity test that we used to evaluate cell viability is MTT assay. The distribution of Dicer, Ago2, CD9, CD63 and eIF2α in both cell lines were analyzed using the indirect immunoperoxidase technique. The exosomal miRNA levels were evaluated by using a miRCURY™ Kit.Results: Decreased eIf2α immunoreactivity following quercetin application was significant in Colo 741 colon cancer cells. Increased Dicer and CD9 immunoreactivities were significant between Colo 320 and Colo 741 colon cancer cells. Additionally, after quercetin application, exosomal miRNA concentrations were increased in both Colo 320 and Colo 741 cell lines.Conclusion: According to our results, total exosomal miRNA concentration and levels of associated proteins were affected after quercetin administration. Additionally, the change in the immunoreactivity of the related proteins after quercetin application differed according to the cell type and origin.
Enhanced fruiting body production and bioactive phytochemicals from white Cordyceps militaris by blending Cordyceps militaris and using cold plasma jet
Authors: Seelarat Weerasak , Sangwanna Sujarinee , Panklai Teerapap , Chaosuan Natthaphon , Bootchanont Atipong , Wattanawikkam Chakkaphan , Subcharoen Ahkasit , Subcharoen Nuttapon , Chanchula Nattapong , Boonyawan Dheerawan , Porjai Porramain 
Published: June 2022

Abstract
The impact of cold plasma jet (CPJ) on fruiting body production and bioactive phytochemicals in white Cordyceps militaris blended with Cordyceps militaris (blended C. militaris) cultured on solid media was evaluated. CPJ was driven by a 12 kV neon transformer with a duty cycle of 50% and a fixed flow rate of 5 L/min. Primarily, reactive oxygen and nitrogen species (RONS) were produced, including nitric oxides, hydroxyl radicals, and atomic oxygen. Before solid media cultivation, the CPJ was activated in liquid media containing potato dextrose agar of blended C. militaris for different treatment times (30 to 120 s). Changes in fresh and dry weights and cordycepin content of the most sensitive blended C. militaris cultivar increased by 22.49, 22.56, and 25.23%, respectively. CPJ treatment markedly increased antioxidant enzymes, including superoxide dismutase and glutathione S-transferase, by 34.71 and 17.42%, respectively. Moreover, CPJ treatment significantly increased the contents of bioactive compounds, including total phenolic content and total flavonoid content. The changes in antioxidant activities in the fruiting bodies of blended C. militaris were assayed using DPPH and ABTS radical scavenging activities to assess ferric-reducing antioxidant power. Therefore, CPJ treatment can represent a promising nonthermal method to enhance fruiting body production and nutritional value of blended C. militaris, which has implications for human health.
Social networks, mobility, and HIV risk among women in the fishing communities of Lake Victoria
Authors: Nakamanya Sarah , Okello Elialilia S. , Kwena Zachary A , Nanyonjo Gertrude , Bahemuka Ubaldo M , Kibengo Freddie M , Ssetaala Ali , Bukusi Elizabeth , Kapiga Saidi , Fast Pat , Seeley Janet , Kidega The Lake Victoria Consortium for Health Research (LVCHR) 
Published: June 2022

Abstract
BackgroundPopulation mobility is a demonstrated barrier to reducing HIV incidence. A clear understanding of social networks and their influence on mobility among women in the fishing communities of Lake Victoria may contribute to tailoring effective interventions that suit the needs of these mobile women. MethodsA cross-sectional qualitative study was conducted to understand mobility patterns among women resident and or working in fishing communities of Lake Victoria in Kenya, Tanzania and Uganda. The study was conducted in six fishing communities from March 2018 to June 2019. The communities were purposively selected, based on population size (1000 people or more) and HIV prevalence of >15% among women aged 18 years or older and mature/emancipated minors aged 15-17 years and had lived in the fishing community for at least six months. In-depth interviews were conducted with 24 key informants and 72 women from the sites in the three countries. Questions focused on women’s social networks and other factors that fuelled/facilitated women’s mobility as well as challenges faced in mobility. Data analysis followed a thematic framework approach.ResultsDifferent social groupings/networks existed among women in fishing communities of Lake Victoria. These included female sex workers, women fish processors/traders, women bar workers/ owners, restaurant workers, and women’s-family networks. Networks encouraged mobility, supporting finding work opportunities, but also increased sexual risks through partner changes. The benefits of networks included information sharing, financial support, and group protection, especially against violence. ConclusionSocial networks and groupings among women in fishing communities of Lake Victoria could be useful in tailoring HIV prevention and HIV care interventions to suit the needs of these highly mobile populations.
Analyzing Answering Patterns in Progress Test Data
Authors: Sieg Miriam , Tomova Mihaela Todorova , Atanet Iván Roselló , Sehy Victoria , Mäder Patrick , März Maren 
Published: June 2022

Abstract
Background: The Progress Test Medicine (PTM) is a 200-question formative test administered to approximately 11,000 students at medical faculties (Germany, Austria, Switzerland) each semester. Participants receive feedback on their knowledge (development) mostly in comparison to their own semester. In this study, we use the data of the assessment to find groups with similar answer patterns.Methods: We performed k-means clustering with a dataset of 5,444 participations, selected cluster number k=5, and answers as features. Subsequently, the data was passed to XGBoost with the cluster assignment as the target enabling the derivation of cluster-relevant questions for each cluster with SHAP. Clusters were examined by total score, answer patterns, and confidence. Relevant questions were evaluated for difficulty, discriminatory index and confidence levels.Results: Three of the five clusters can be seen as ’performance clusters’: cluster 0 (n=761) consists predominantly of participants in higher semesters. Relevant questions tend to be difficult, but participants answer confidently and correctly. Participants in cluster 1 (n=1,357) are amidst their study, cluster 3 (n=1,453) consists mainly of early study stage participants. Guessed questions increase successively, relevant questions are rather easy. Two clusters are mostly ‘leaver clusters’: participants in cluster 2 (n=384) drop out of the test about halfway through after initially performing well. Cluster 4 (n=1,489) includes students from the first semesters - but also "non-serious" participants with mostly wrong guesses or no answers. Conclusion: Clusters dissolve the allocation to one's own semester and place performance in the context of the overall cooperation.