bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum copeptin as a biomarker of hypertension in children with obesity
Authors: Gor Zeynep , Bezen Digdem , Turkmenoglu Yelda , Vurgun Eren , Irdem Ahmet , Dursun Hasan 
Published: September 2022

AbstractBackgroundHypertension (HT) in obesity has been reported frequently in children in recent years. The role of copeptin and uric acid here are not well known. We aimed to investigate the relationship between HT and serum copeptin and uric acid levels in children with obesity.MethodsWe included 80 children with obesity who were admitted to our hospital between April 2018 and September 2018. The patients were separated into two groups: hypertensive and non‐hypertensive. Serum copeptin levels were measured using the enzyme‐linked immunosorbent assay.ResultsCopeptin levels were significantly higher in patients with HT than in those without (p = 0.0001). In addition, serum uric acid levels in patients with HT were significantly higher, while the serum potassium levels were significantly lower (p = 0.01) than in those without HT (p = 0.001). In correlation analyses, a positive correlation was detected between blood sodium and copeptin levels (p = 0.037).ConclusionsHypertensive children with obesity had higher serum copeptin and uric acid and lower blood potassium levels. Moreover, copeptin levels were positively correlated with blood sodium levels. Thus, in addition to copeptin, serum uric acid, potassium, and sodium levels may be important in the diagnosis and follow‐up of children with HT.
An early perceptual locus of absolute pitch
Authors: Ngan Vince S. H. , Cheung Leo Y. T. , Ng Hezul T. Y. , Yip Ken H. M. , Wong Yetta Kwailing , Wong Alan C.‐N. 
Published: September 2022

AbstractAbsolute pitch (AP) refers to the naming of musical tone without external reference. The influential two‐component model states that AP is limited by the late‐emerging pitch labeling process only and not the earlier perceptual and memory processes. Over the years, however, support for this model at the neural level has been mixed with various methodological limitations. Here, the electroencephalography responses of 27 AP possessors and 27 non‐AP possessors were recorded. During both name verification and passive listening, event‐related potential analyses showed a difference between AP and non‐AP possessors at about 200 ms in their response toward tones compared with noise stimuli. Multivariate pattern analyses suggested that pitch naming was subserved by a series of transient processes for the first 250 ms, followed by a stage‐like process for both AP and non‐AP possessors with no group differences between them. These findings are inconsistent with the predictions of the two‐component model, and instead suggest the existence of an early perceptual locus of AP.
Blood conservation strategies at United States hospitals during the COVID‐19 pandemic: Findings from a multi‐institutional analysis ‐ International Society of Blood Transfusion survey
Authors: Jacobs Jeremy W. , Karafin Matthew S. , Allen Elizabeth S. , Abels Elizabeth , Park Yara A. , Stephens Laura D. , Ward Dawn C. , Woo Jennifer S. , Gehrie Eric A. , Booth Garrett S. , Adkins Brian D. 
Published: September 2022

AbstractBackgroundDue to the coronavirus disease 2019 (COVID‐19) pandemic, the transfusion medicine community has experienced unprecedented blood supply shortages since March 2020. As such, numerous changes to everyday practice have occurred with a specific emphasis on blood conservation. We sought to determine the strategies used to mitigate blood shortages and promote blood conservation during the pandemic.MethodsAn anonymous, 37‐question survey was developed using Research Electronic Data Capture and distributed via e‐mail to transfusion medicine specialists across the US obtained via publicly available databases.ResultsAmongst surveyed [41.1% response rate (51/124 institutions)], 98.0% experienced a product shortage, with the greatest number reporting red blood cell (RBC) shortages (92.0%). This led to 35.3% of institutions altering the composition and/or number of blood product suppliers, including a 100% increase in the number of institutions acquiring blood from organizations that connect hospital transfusion services with blood collection centers (e.g., Blood Buy) compared to before March 2020. Prospective triaging of blood products was the most common blood conservation strategy (68.1%), though 35.4% altered their RBC exchange or transfusion program for patients receiving chronic RBC transfusion/exchange. As a result of these changes, 78.6% of institutions reported that these changes resulted in a reduction in blood product usage, and 38.1% reported a decrease in product wastage.ConclusionsMost hospitals experienced the effects of the supply shortage, and many of them implemented blood conserving measures. Conservation strategies were associated with decreased blood utilization and waste, and future studies could evaluate whether these changes persist.
Effects of commercial amniotic membrane extract on the re‐epithelialization time and the early expression of matrix metalloproteinase‐9 in cats with experimentally induced corneal ulcers
Authors: Silveira Bruna Carvalho , Ribeiro Alexandre Pinto , Pizzinatto Fabio Dumit , Lobo Paloma Moraes , Miranda Hanna Rodrigues , de Assis Pereira Nathalia 
Published: September 2022

AbstractObjectivesTo investigate whether a commercially available amniotic membrane extract (AME) can accelerate corneal wound healing and suppress the early expression of MMP‐9 in the tears of cats with experimentally induced superficial ulcerative keratitis.ProceduresA total number of 16 cats were included. At the end of keratectomy, cats in the treatment group (TG, n = 8) received 40 μl of AME (EyeQ® Amniotic Eye Drops, Vetrix®) four times daily, while cats in the control group (CG, n = 8) received 40 μl of saline at the same time points. Tears were collected 24 and 48 h after keratectomy, and the total MMP‐9 was quantified by ELISA.ResultsThe corneal re‐epithelialization rate did not differ between groups (p = .26), being 0.48 ± 0.05 mm2/h in the CG and 0.41 ± 0.03 mm2/h in the TG. Similarly, the average time to achieve corneal wound healing did not differ between groups (p = .25) and was 61.50 ± 3.54 h in the CG and 70.50 ± 6.71 h in the TG. The dimensions of the ulcerated areas also did not differ at any time point between the groups (p > .05). In both groups, corneas healed without scarring, pigmentation, or vascularization. The expression of MMP‐9 in the tears was similar in both groups at 24 h post‐keratectomy, with a slight decrease at 48 h (p > .05).ConclusionsThe instillation of a commercial AME (EyeQ®) is safe, but it did not decrease the corneal re‐epithelialization time or the early expression of MMP‐9 in the tears of cats with experimentally induced superficial ulcerative keratitis in this study.
Extracellular vesicles and their non‐coding RNA cargos: Emerging players in cardiovascular disease
Authors: Collado Aida , Gan Lu , Tengbom John , Kontidou Eftychia , Pernow John , Zhou Zhichao 
Published: September 2022

AbstractExtracellular vesicles (EVs), including exosomes, microvesicles and apoptotic bodies, have recently received attention as essential mechanisms for cell‐to‐cell communication in cardiovascular disease. EVs can be released from different types of cells, including endothelial cells, smooth muscle cells, cardiac cells, fibroblasts, platelets, adipocytes, immune cells and stem cells. Non‐coding (nc)RNAs as EV cargos have recently been investigated in the cardiovascular system. Up‐ or downregulated ncRNAs in EVs have been shown to play a crucial role in various cardiovascular diseases. Communication via EV‐derived ncRNAs can occur between cells of the same type and between different types of cells involved in the pathophysiology of cardiovascular disease. In the present review, we highlight the important aspects of diverse cell‐derived EVs and their ncRNA cargos as disease mediators and potential therapeutic targets in atherosclerosis, coronary artery disease, ischaemic heart disease and cardiac fibrosis. In addition, we summarize the potential of EV‐derived ncRNAs in the treatment of cardiovascular disease. Finally, we discuss the different methods for EV isolation and characterization. A better understanding of the specific role of EVs and their ncRNA cargos in the regulation of cardiovascular (dys)function will be of importance for the development of diagnostic and therapeutic tools for cardiovascular disease.
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Analyses of Damping Sustainability of Additively Manufactured Nickel Alloy Components Subjected to High Strain Loading Cycles
Authors: Hollkamp John P. , Scott-Emuakpor Onome , Celli Dino 
Published: September 2022

Abstract
While integrally bladed rotors in turbine engines have multiple benefits, they are more susceptible to vibration and as a result, high cycle fatigue failure. In response, damping treatments such as viscoelastic layers, hard coatings, and particle dampers have been utilized to reduce vibration of integrally bladed rotors and promote long service life. In recent experiments, nickel-based alloy 718 structural beams representative of turbine blades were manufactured via laser powder bed fusion (LPBF) with internal geometries containing unfused powder. Compared to fully fused beams, these beams with internal particle dampers have demonstrated a significant improvement in damping performance, suppressing vibrations by as much as 95%. However, the inherent damping of the particle dampers decreases as the strain amplitude increases when some of the unfused powder fuses to the walls of the pockets. This study investigates the effect of the location of the particle dampers within the beam on the sustainability of its damping performance. To compare the effect of the particle damper's location, the LPBF nickel-based alloy 718 beams are subjected to successive resonance dwells with increasing strain amplitude. After each dwell, the damping performance is assessed via the half-power bandwidth method of the frequency response function. Results from this study indicate that while the location of the particle dampers within the specimen does influence when the damping begins to degrade, it is not the optimal parameter for damping sustainability. The aim of this and future work is to improve the long-term damping performance and viability of the internal particle damper so that it can be more effectively utilized to extend the lifetime of turbomachinery components.
Design of a Compact Dry Cooler With an Aluminum Heat Exchanger Core for a Supercritical CO2 Power Cycle Is Evaluated for a Concentrating Solar Power Application
Authors: Katcher Kelsi M. , Amogne Dereje , Patil Abhay 
Published: September 2022

Abstract
As the supercritical CO2 power cycle develops and the component technologies mature, there is still a need to reduce the associated capital and operating costs to maintain a competitive levelized cost of electricity (LCOE) in order to enter the market. When considering concentrating solar power (CSP) coupled with an sCO2 power block and sensible thermal storage, the technology presents a clean source for utility-scale power generation to support baseload or peak-load electrical demand. However, the LCOE of the technology is still considered higher than the competing technologies and should be reduced to better compete in the market; 2030 targets for dispatchable solar plants are 5¢/kWh for baseload CSP and 10¢/kWh for peaker plants, as set by the United States Department of Energy. In response to this need, this study is targeting improvements in the power cycle precooler to reduce power block contribution to LCOE. This study considers a dry cooler, as CSP plants are sensitive to water consumption because many installations are slated for remote or arid locations where solar irradiance is very high, but water is scarce. Furthermore, the power block footprint for an sCO2 system is quite compact, especially as compared to a steam cycle. Therefore, there is interest in installing a more compact dry cooler that is proportional to the reduced footprint sCO2 power block, while conventional dry coolers are an order of magnitude larger. The competing goals of size, performance, and cost were considered in this study to develop a compact dry cooler that can easily be packaged with the power block, significantly reducing the installation and transport cost compared to the current state of the art, while maintaining or improving upon the heat transfer performance and impact on plant LCOE. This paper details the high-level findings of a large dry cooler sensitivity study for design point selection, design of the compact dry cooler, expected year-round performance for the dry cooler and the power cycle, and the predicted LCOE for a 30-year plant life. It was found that an aluminum heat exchanger core can be suitably designed to meet the pressure and temperature requirements for a precooler in an sCO2 recompression Brayton cycle. The dry cooler assembly was found to have improved heat transfer performance, allowing for increased cycle efficiencies and a reduced plant LCOE. When coupled with a centrifugal blower and compact transition duct, the dry cooler assembly was able to reduce the installation footprint by over 50%.
Metatarsophalangeal Joint Dynamic Stiffness During Toe Rocker Changes With Walking Speed
Authors: Nigro Luke , Arch Elisa S. 
Published: September 2022

Dynamic joint stiffness (or simply “stiffness”) is a customization criteria used to tune mechanical properties of orthotic and prosthetic devices. This study examines metatarsophalangeal (MTP) joint stiffness during the toe-rocker phase of barefoot walking and establishes baseline characteristics of MTP joint stiffness. Ten healthy individuals walked at 4 speeds (0.4, 0.6, 0.8, and 1.0 statures·s−1) over level ground. MTP sagittal plane joint angles and moments were calculated during the toe-rocker phase of stance. Least-squares linear regressions were conducted on the MTP moment versus angle curve to determine joint stiffness during early toe rocker and late toe rocker. Multilevel linear models were used to test for statistically significant differences between conditions. Early toe rocker stiffness was positive, while late toe rocker was negative. Both early toe rocker and late toe rocker stiffness increased in magnitude significantly with speed. This study establishes baseline characteristics of MTP joint stiffness in healthy walking, which previously had not been examined through a range of controlled walking speeds. This information can be used in the future as design criteria for orthotic and prosthetic ankle and ankle–foot devices that can imitate, support, and facilitate natural human foot motion during walking better than existing devices.
New Data on the Biology of Kildin Cod Gadus morhua kildinensis (Gadidae) from Lake Mogilnoe (Kildin Island, the Barents Sea) Obtained by Echo Sounding and Underwater Photography
Authors: Stroganov A. N. , Strelkov P. P. , Shilin N. I. , Mukhina N. V. , Menshakova M. Yu. , Fedyuk M. L. 
Published: September 2022

Abstract
The distribution of the Kildin cod Gadus morhua kildinensis in Lake Mogilnoye (Kildin Island, Barents Sea) is assessed based on the results of echo sounding and hydrological surveys, underwater photography and field observations. Underyearlings live in the lower part of the freshened upper layer, younger age groups locate in vicinity of the natural dam in the southeastern part of the lake, adults are distributed along the water area of the lake within the depth range of 4.0–6.4 m (mainly 5.0–5.4 m), characterized by favorable temperature values, water salinity, and oxygen saturation.
Synthesis, Structure, and Magnetic Properties of Ditopic Ferrocenylboron-Capped Tris-Pyridineoximate Iron, Cobalt, and Nickel(II) Pseudoclathrochelates
Authors: Belova S. A. , Belov A. S. , Efimov N. N. , Pavlov A. A. , Nelubina Yu. V. , Novikov V. V. , Voloshin Y. Z. 
Published: September 2022

Abstract
Tris-pyridineoximate iron, cobalt, and nickel(II) pseudoclathrochelates with apical ferrocenyl substituent were obtained in the reasonable yields (50–70%) in a boiling ethanol by the template condensation of 2-acetylpyridineoxime with ferrocenylboronic acid on the corresponding M2+ ion as a matrix. The composition and structure of new ditopic compounds, isolated in the forms of their ionic associates with perchlorate anion, were determined using elemental analysis, UV-vis spectroscopy, MALDI-TOF mass spectrometry, and NMR spectroscopy. According to the magnetometry data, the iron(II) pseudoclathrochelate is a diamagnetic compound, while the temperature dependences of magnetic susceptibility of the nickel and cobalt(II) complexes are characteristic of the high-spin systems with S = 1 and 3/2, respectively. As follows from the X-ray diffraction data for the iron and nickel(II) pseudoclathrochelates, the Ni–N distances (2.15–2.17 Å) are characteristic of the high-spin Ni2+ complexes, while they in its iron(II)-containing analog, slightly exceed of 2 Å, thus suggesting the low-spin state of this ion.
Hybrid Microwave Solid-Phase Synthesis of Wollastonite Based on Natural Renewable Raw Materials
Authors: Shichalin O. O. , Tarabanova A. E. , Papynov E. K. , Fedorets A. N. , Buravlev I. Yu. , Kapustina O. V. , Kornakova Z. E. , Gribova V. V. , Gribanova S. S. 
Published: September 2022

Abstract
A method was tested to perform the solid-phase synthesis of ceramic wollastonite under hybrid microwave heating using such natural renewable raw materials as sea shells as a source of CaCO3 with the addition of commercial SiO2 powder. The XRD, SEM, TGA, and EDS methods were used to explore the effect of the mechanical homogenization time and the conditions for the chemical interaction of raw materials, provided that the required phase composition is reached. It was studied how temperature (800–1150°C) and time (15–60 min) of sintering affect the composition and structure of the ceramic wollastonite samples, including those in the presence of the strengthening additive sodium tetraborate. The formation of an apatite (Ca10(PO4)6(OH)2) layer on the surface of the obtained samples under conditions of their contact with artificial human blood plasma was assessed to confirm the biocompatible properties of these materials. The proposed method of synthesis is promising for obtaining a chemically pure valuable biomaterial in the form of synthetic wollastonite with the possibility of rational use of biogenic raw materials.
Circular Permutants of BrUSLEE Protein as Fluorescent pH Indicators
Authors: Mamontova A. V. , Simonyan T. R. , Lukyanov K. A. , Bogdanov A. M. 
Published: September 2022

Abstract—
Two variants of circularly permuted BrUSLEE, a green fluorescent protein with a short fluorescence lifetime, have been engineered. We characterized the pH-dependence of fluorescence decay kinetics of these fluorophores. It was shown that both permutants (cpBrUS and cpBrUS-145) exhibit three-component fluorescence decay kinetics, with the lifetime of the one component varying within the ~3000–300 ps range upon pH shift from 5.5 to 9.0. At the same time, the original BrUSLEE does not show a significant change in the fluorescence decay kinetics within the physiologically relevant pH-range of 6.0–8.5. The described pH-dependence allows considering the BrUSLEE permutants as pH indicators with the fluorescence lifetime readout.
Association of concussion with high school academic standing: sex, school grade and race as stratifiers
Authors: Takagi-Stewart Julian , Qiu Qian , Mills Brianna , Avery Aspen D , Muma Amy , Vavilala Monica S 
Published: September 2022

IntroductionThe purpose was to examine the association between concussion history and academic standing among high school students, and whether the association varies by sex, school grade and race/ethnicity.MethodsData from the 2019 Youth Risk Behaviour Survey were used for our cross-sectional study. Exposure was self-reported history of concussions in the past 12 months. Outcome was self-reported academic standing in the past 12 months. Poisson regression was used to analyse the exposure–outcome association, and whether there were differences by our stratifying variables.ResultsHaving a history of concussion in the past 12 months was significantly associated with a higher risk of poor academic standing during the same period, and the association varied by race/ethnicity.DiscussionYouth with a history of concussion may be at risk for poorer academic standing, indicating to the importance of prevention. Future studies are needed to examine the interaction of race/ethnicity on the presented association.
Randomised feasibility trial of a virtual intervention to address infant car seat misuse
Authors: Kendi Sadiqa , Taylor Michael F , Thomas Bobbe , Khemraj Uma D , Mohamed Mohamed A. , Macy Michelle L. , Chamberlain James M. 
Published: September 2022

BackgroundSerious car seat installation errors occur at high rates in infants and children. These errors significantly increase the risk of child injury in a motor vehicle crash, and few interventions have addressed the challenge longitudinally.MethodsThis was a pilot randomised controlled feasibility trial of virtual car seat safety checks for caregivers of newborns recruited from an urban newborn nursery. The control (enhanced usual care (EUC)) group received an in-person car seat check as a newborn and virtual check at 9 months. The intervention group received two additional virtual checks at 3 and 6 months. Installation and infant positioning errors were documented and corrected by a child passenger safety technician (CPST). We measured feasibility and acceptability by tracking caregiver and CPST challenges, and caregiver retention. Group differences were tested for statistical significance using χ2or Fisher’s exact test for categorical variables, and two sample t-tests for continuous variables.Results33 caregivers were randomised to the EUC and 28 to the intervention group. Virtual checks were feasible, with variable participation levels at each quarter. Wi-Fi and app challenges noted in 30%. There was satisfaction with the virtual car seat checks. At baseline, car seat installation and infant positioning errors occurred at equal frequency, and at 9 months the intervention group had a significantly lower mean proportion than the EUC group in all categories of errors. In summary, virtual seat checks are feasible and the optimal timing of repeat checks requires additional study. A larger study is needed to further evaluate the effect of longitudinal virtual checks on errors.