bluuebunny/crossref_metadata_2025_split huggingface dataset:
How to approach a neurogenetics diagnosis in different European countries: The European Academy of Neurology Neurogenetics Panel survey
Authors: Mancuso Michelangelo , Houlden Henry , Molnar Maria Judit , Filla Alessandro , Breza Marianthi , Graessner Holm , Bassetti Claudio L. A. , Boesch Sylvia 
Published: March 2022

AbstractBackground and purposeSeven thousand rare diseases have been identified; most of them are of genetic origin. The diagnosis of a neurogenetic disease is difficult, and management and training programs are not well defined through Europe. To capture and assess care needs, the Neurogenetics Panel of the European Academy of Neurology (EAN) has performed an explorative survey.MethodsThe survey covering multiple topics of neurogenetics was sent to all neurologists and neuropediatricians affiliated with the EAN practicing in Europe.ResultsWe collected answers from 239 members based in 40 European member states. Even though most of the responders were aware of neurogenetic diseases, when we came to amenability of carrying out a complete genetic diagnosis, almost one‐third of the responders declared they were not happy with the current way of ordering genetic analyses in their countries. Furthermore, although single‐gene analysis is diffusely present in Europe, whole exome and genome sequencing are not easily accessible, with considerable variabilities among countries. Almost 10% of the responders did not know if presymptomatic and prenatal diagnosis was available in their countries, and 47.3% were not aware of which newborn screening programs were available. Finally, 96.3% of responders declared that there is a need for education and training in neurogenetics.ConclusionsWe believe that this survey may be of importance for all European stakeholders in neurogenetics in identifying key priorities, targeting areas to encourage education/travel fellowships, and educational seminars in the future, because this area will only accelerate, and diagnostic requirements will expand.
RETRACTED: Measuring systemic and systematic risk in the financial markets using artificial intelligence
Authors: Kamruzzaman M. M. , Alruwaili Omar , Aldaghmani Dhiyaa 
Published: March 2022

AbstractFinancial markets are exposed to sharp price volatility, and defaults and errors, which results in high risks for relevant stakeholders. In such markets, success depends upon the quality and quantity of information available to assist the decision‐making. Artificial intelligence (AI), in this regard, can measure or predict systemic and systematic risk in the financial markets. This research study aims to highlight how the risks can be measured and controlled with the support and integration of modern AI and machine learning mechanisms. By performing a review‐based methodology, the study first presents an explanation of the models, which is followed by proposing a new AI‐based model. The model relies on several financial system's inputs, which include portfolio data, trade data, market data, financial reports, market condition, and sector‐wise data. The systemic and systematic risk is then assessed through a number of outputs that the AI algorithm will process, in the form of an interactive dashboard. The article further tests that model and presents benefits and implications.
Haitian and Haitian American experiences of racism and socioethnic discrimination in Miami‐Dade county: At‐risk and court‐involved youth
Authors: Cela Toni , Marcelin Louis Herns , Waldman Rachel , Dembo Richard , Demezier Danna , Clement Roy , Arcayos Alexandra , Santisteban Daniel , Jean‐Gilles Michèle , Hogue Aaron 
Published: March 2022

AbstractWe examine how juvenile justice‐involved youth of Haitian descent in Miami‐Dade County cope with structural racism and its impact on their mental health. Drawing on longitudinal ethnography, psychosocial assessment data, and a family‐based clinical intervention funded by the National Institute on Drug Abuse, this article explores youth narratives of discrimination prior to and during the COVID‐19 pandemic. We use critical race theory and theory of practice to understand youths’ perceptions as racialized bodies and stigmatized selves, highlighting the experiences and perspectives of a particular black immigrant group, ethnic beings caught up in the everyday practices of racialization, sociocultural marginalization, and racism. We frame these experiences as a variation of the complex continuum of structural racism and racial domination in the US. These experiences have caused anger, fear, anxiety, chronic anticipatory distress, and hopelessness among youth of Haitian descent. We conclude with some recommendations for therapeutic support that encourages youth to process their experiences, promotes their development of a positive self‐concept, and provides them with mind‐body techniques to attenuate the physical impacts of discriminatory events. The clinical trial registration number for this study intervention is NCT03876171.
Giving an account of patients' experience: A qualitative study on the care process of hip and knee osteoarthritis
Authors: Battista Simone , Manoni Mattia , Dell'Isola Andrea , Englund Martin , Palese Alvisa , Testa Marco 
Published: March 2022

AbstractIntroductionDespite the publication of clinical practice guidelines, the quality of the care process as experienced by patients with osteoarthritis (OA) appears suboptimal. Hence, this study investigates how patients with OA experience their disease and care process, highlighting potential elements that can enhance or spoil it, to optimise their quality of care.MethodsA qualitative study based on semi‐structured interviews. Patients with hip and knee OA in Italy were interviewed. The interview guide was created by a pool of health professionals and patients. The interviews were analysed through a theme‐based analysis following a philosophy of descriptive phenomenological research.ResultsOur analysis revealed seven main themes: (1) Experiencing a sense of uncertainty, as interviewees perceived treatment choices not to be based on medical evidence; (2) Establishing challenging relationships with the self and the other, as they did not feel understood and felt ashamed or hopeless about their condition; (3) Being stuck in one's own or the health professionals' beliefs about the disease management, as a common thought was the perception of movement as something dangerous together with a frequent prescription of passive therapies; (4) Dealing with one's own attitudes towards the disease; Understanding (5) the barriers to and (6) the facilitators of the adherence to therapeutic exercise, which revolve around the therapy cost, the time needed and the patients' willingness to change their life habits and (7) Developing an uneasy relationship with food since the diet was considered as something that “you force yourself to follow” and overeating as a way “to eat your feelings”.ConclusionThe lack of clear explanations and a negative attitude towards first‐line nonsurgical treatments (mainly physical exercise), which are considered as a way to fill the time while waiting for surgery, underlines the importance of providing patients with adequate information about OA treatments and to better explain the role of first‐line intervention in the care of OA. This will enhance patient‐centred and shared decision‐making treatments.Patient ContributionPatients with hip and knee OA participated in creating the interview and contributed with their experience of their care process.
The occurrence of antibiotic-resistant bacteria on the clothes of nursery teachers in daycare centres
Authors: Žagar Dominika , Zore Anamarija , Godič Torkar Karmen 
Published: March 2022

Abstract

Aims
Childcare facilities act as microenvironments that facilitate and promote the selection, spread and transmission of antibiotic-resistant micro-organisms in the community. We focused on the study of antimicrobial resistance and genetic predispositions for β-lactamase production in bacterial isolates from nursery teachers' clothing.

Methods and Results
Antimicrobial resistance of bacterial strains belonging to Enterobacteriaceae, Enterococcus, Staphylococcus spp., Pseudomonas spp. and Bacillus spp. isolated from 80 samples of nursery teachers' clothing was determined. The selected ESβL genes were found in 30 (44.1%) of 68 strains examined. The CTX-M type ESβL determinants were detected in 15.4%, 71.5% and 42.5% of the Enterobacteriaceae, Pseudomonas and Bacillus isolates, respectively. The OXA-type coding genes were detected only in strains of the genera Pseudomonas (57.1%) and Bacillus (48.6%). Thus, most B. cereus strains were sensitive to the recommended antibiotics used to treat infections caused by these bacteria. Methicillin resistance was phenotypically confirmed in 27 (14.6%) of 185 staphylococcal isolates. Four isolates (2.2%) were identified as MRSA. Vancomycin resistance was not observed in any of the staphylococcal and enterococci strains.

Conclusions
This study has shown that potential pathogens have been isolated from the clothing of nursery teachers, posing a risk of transmission to children. These clothes should be maintained and properly laundered to avoid cross-contamination and the spread of multidrug-resistant (MDR) bacteria in childcare centres.

Significance and impact of the study
This study provides insight into the route of transmission of MDR micro-organisms through the clothing of nursery teachers, to which greater importance should be given in the future. Proper procedures for the cleaning and use of clothing in daycare centres should be clarified and standardized.
A review: Developing an ecological model approach to co‐worker incivility experiences of new graduate nurses
Authors: Blackstock Sheila , Cummings Greta , Glanfield Florence , Yonge Olive 
Published: March 2022

AbstractAimTo explore how an ecological approach be used to explore relationships among workplace empowerment, authentic leadership, trust in management, areas of work life and co‐worker incivility experiences of new graduate nurses.DesignKey concepts related to new graduate nurses' incivility experience informed the research question building on the findings of our first author's integrative review. Second, relevant theories and concepts were identified by conducting a literature review. Third, the themes build on prior theories and factors to propose a hypothetical model.Data Sources(2016–2019) CINAHL, OVID, PSYCINFO, PUBMED, EBSCO, ERIC, SCOPUS, Cochrane Library; PROQUEST and Google Scholar.Review Methods(a) Constructs identified in an IR (Blackstock et al., 2018) guided a literature review on predictive variables linked to new graduate nurse's co‐worker incivility experiences; (b) an ecological approach was explored; and (c) we demonstrate how multidimensional organizational factors related to incivility experiences of new graduate nurses can be situated in an ecological model.ResultsStructural and organizational factors, and nurse leaders influencing new graduate nurses' experiences are situated in an ecological model. Placing new graduate nurses' co‐worker incivility experiences in the microsystem and close to the mesosystem (nurse supervisor) and exosystem (workplace empowerment) of our ecological model provides new insights into their incivility experiences and informs future research.ConclusionThe ecological approach and operational definition of incivility help to clarify incivility behaviours as not merely individual behaviours observed by others needing corrective cognitive behaviours, nor support in a graduate transition program, but rather a symptom of work environment factors contributing to multidimensional work environments of new graduate nurses' and influence incivility behaviours.ImpactNew graduate nurse co‐worker incivility research could measure change across time and across system domains informed by this ecological approach and can shape new ways of thinking about how to prevent and mitigate incivility.
The relationship between posttraumatic stress disorder, posttraumatic growth, and rumination in adolescents after earthquake: A systematic review
Authors: Turan Nazan , Yılmaz Didem Yüksel , Ertekin Kutluhan 
Published: March 2022

AbstractPurposeThis systematic review aims to examine, from an interdisciplinary perspective, the relationship between posttraumatic stress disorder (PTSD), posttraumatic growth (PTG), and rumination in adolescents after an earthquake. The aim of the review is to provide high‐quality, evidence‐based recommendations that contribute to the roles of psychiatric nurses and the development of psychosocial support systems.Design and MethodsThis study has been conducted in line with the Centres for Reviews and Dissemination (CRD) guideline which guides preparation for transparent reporting of meta‐analysis and systematic reviews.FindingsDespite the limited evidence, it was concluded that it is important to identify the psychological processes that lead to PTG and reduce the incidence of PTSD in earthquake‐affected adolescents.Practical ImplicationsThis evidence shows how important it is to raise the awareness of healthcare providers in different disciplines, including psychiatric nurses, around the need for psychosocial support interventions following a natural disaster.
Immediate impact of child maltreatment on mental, developmental, and physical health trajectories
Authors: Winter Sibylle M. , Dittrich Katja , Dörr Peggy , Overfeld Judith , Moebus Imke , Murray Elena , Karaboycheva Gergana , Zimmermann Christian , Knop Andrea , Voelkle Manuel , Entringer Sonja , Buss Claudia , Haynes John‐Dylan , Binder Elisabeth B. , Heim Christine 
Published: March 2022

ObjectiveThe immediate impact of child maltreatment on health and developmental trajectories over time is unknown. Longitudinal studies starting in the direct aftermath of exposure with repeated follow‐up are needed.MethodWe assessed health and developmental outcomes in 6‐month intervals over 2 years in 173 children, aged 3–5 years at study entry, including 86 children with exposure to emotional and physical abuse or neglect within 6 months and 87 nonmaltreated children. Assessments included clinician‐administered, self‐ and parent‐report measures of psychiatric and behavioral symptoms, development, and physical health. Linear mixed models and latent growth curve analyses were used to contrast trajectories between groups and to investigate the impact of maltreatment features on trajectories.ResultsMaltreated children exhibited greater numbers of psychiatric diagnoses (b = 1.998, p < .001), externalizing (b = 13.29, p < .001) and internalizing (b = 11.70, p < .001) symptoms, impairments in cognitive (b = −11.586, p < .001), verbal (b = −10.687, p < .001), and motor development (b = −7.904, p = .006), and greater numbers of medical symptoms (b = 1.021, p < .001) compared to nonmaltreated children across all time‐points. Lifetime maltreatment severity and/or age at earliest maltreatment exposure predicted adverse outcomes over time.ConclusionThe profound, immediate, and stable impact of maltreatment on health and developmental trajectories supports a biological embedding model and provides foundation to scrutinize the precise underlying mechanisms. Such knowledge will enable the development of early risk markers and mechanism‐driven interventions that mitigate adverse trajectories in maltreated children.
Analysis of relapse by inflammatory Rasch‐built overall disability scale status in the PATH study of subcutaneous immunoglobulin in chronic inflammatory demyelinating polyneuropathy
Authors: Merkies Ingemar S. J. , van Schaik Ivo N. , Bril Vera , Hartung Hans‐Peter , Lewis Richard A. , Sobue Gen , Lawo John‐Philip , Mielke Orell , Cornblath David R. ,   the PATH study group
Published: March 2022

AbstractClinical trials in chronic inflammatory demyelinating polyneuropathy (CIDP) often assess efficacy using the ordinal Inflammatory Neuropathy Cause and Treatment (INCAT) disability score. Here, data from the PATH study was reanalyzed using change in Inflammatory Rasch‐built Overall Disability Scale (I‐RODS) to define CIDP relapse instead of INCAT. The PATH study comprised an intravenous immunoglobulin (IVIG) dependency period and an IVIG (IgPro10 [Privigen]) restabilization period; subjects were then randomized to weekly maintenance subcutaneous immunoglobulin (SCIG; IgPro20 [Hizentra]) 0.2 g/kg or 0.4 g/kg or placebo for 24 weeks. CIDP relapse was defined as ≥1‐point deterioration in adjusted INCAT, with a primary endpoint of relapse or withdrawal rates. This retrospective exploratory analysis redefined relapse using I‐RODS via three different cut‐off methods: an individual variability method, fixed cut‐off of ≥8‐point deterioration on I‐RODS centile score or ≥4‐point deterioration on I‐RODS raw score. Relapse or withdrawal rates were 47% for placebo, 34% for 0.2 g/kg IgPro20 and 19% for 0.4 g/kg IgPro20 using the raw score; 40%, 28% and 15%, respectively using the centile score, and 49%, 40% and 27%, respectively using the individual variability method. IgPro20 was shown to be efficacious as a maintenance therapy for CIDP when relapse was defined using I‐RODS. A stable response pattern was shown for I‐RODS across various applied cut‐offs, which could be applied in future clinical trials.
Attitudes towards prevention of cervical cancer and early diagnosis among female academicians
Authors: Doğan Nurhan , Fışkın Gamze 
Published: March 2022

AbstractBackgroundIt is important for public health to determine the awareness of cervical cancer, which is preventable and treatable when detected at an early stage.AimThis study was conducted to determine female academicians' attitudes towards prevention and early diagnosis of cervical cancer and the factors affecting them.MethodsThis descriptive study was conducted with 211 female academicians working in all departments of a university. In the study, the data were collected using questionnaire form, the attitude scale for early diagnosis of cervical cancer, and the attitudes towards prevention of cervical cancer scale.ResultsIt was determined that 68.2% of the female academicians had knowledge about the pap smear test; however, 41.0% of them did not have the test because they could not find time, and 56.4% had the knowledge about the pap smear test from a healthcare professional. It was determined that academicians had lower scores from the Attitude Scale for Early Diagnosis of Cervical Cancer (88.55 ± 9.75) and above‐average scores from the Attitudes Towards Prevention of Cervical Cancer Scale (74.30 ± 15.92). It was found that area of expertise, income status, history of infectious disease, and vaginal douching affected both the early diagnosis of cervical cancer and the attitudes towards prevention of it.ConclusionThe female academicians inadequate attitudes towards early diagnosis of cervical cancer and better attitudes towards prevention. Nurses and administrators should encourage female academics and all women to screen for cervical cancer.
Current Tobacco Use Trends and Harm Perceptions Among High School Students by Asthma Status and Sex, 2012‐2018
Authors: Miura Sarah Selica T. , Bernat Debra , Reid Keshia M. , Macdonald Megan , Porter Lauren , Choi Kelvin 
Published: March 2022

ABSTRACTBACKGROUNDTobacco use is known to worsen asthma management. No studies have investigated how trends in youth tobacco use and related harm perceptions vary by asthma status and sex. This study examined these trends among Florida high school students during 2012‐2018.METHODSData from the 2012, 2014, 2016, and 2018 Florida Youth Tobacco Survey were analyzed. Public high school students (grades 9‐12) with known asthma status were included along with their current tobacco product use, tobacco product harm perceptions, and demographics. Weighted multivariable logistic regression was used to assess trends in tobacco product use and harm perceptions and test differences by asthma status and sex.RESULTSFrom 2012 to 2018, high school students with asthma had the slowest decline in cigarette and cigar use prevalence (asthma status‐time interaction p = .01) compared to those with no asthma. Cigarette and cigar smoking were perceived as less harmful over time, except among females with asthma who smoked cigarettes (p < .05).CONCLUSIONSThose with asthma showed a slower decline and were more likely to smoke cigarettes. Results indicate that further public health efforts are needed to address tobacco use among high school students with asthma.
The effects of genetic variation in seed parent lines for high biomass F1 sorghum (Sorghum bicolor) in the breeding process
Authors: Osanai Kousuke , Honda Toshimitsu , Kawahigashi Hiroyuki , Yonemaru Jun‐ichi , Kasuga Sigemitsu 
Published: March 2022

AbstractThe agronomic traits of sorghum F1 lines from 93 seed parent lines crossed with a fixed pollen parent were evaluated in three different locations, namely, Chiba, Miyazaki and Nagano, in Japan in 2016 and 2017. Genomic DNA extraction from 93 sorghum parental lines and subsequent analysis were performed for determining genetic diversity. Data on single nucleotide polymorphisms (SNPs) were obtained through the Genotyping by Sequencing method. Overall, 3,577 SNPs were obtained from the parent seed lines and were grouped into four clusters characterized by stem length and lodging resistance. Genome‐wide association studies were conducted using field data to identify genes that conferred agronomic traits. There were peaks in stem length, dry matter weight, lodging and aphid damage on Chr. 9, which covered the Dw1 gene locus, suggesting that the gene exerted a multi‐faced effect on agronomic traits. The F1 lines from the seed parent lines with the homozygous dw1 mutant gene were likely to have shorter stem length, lower dry matter weight, resistance to lodging and severer aphid damage.
Federalism: Contemporary political philosophy issues
Authors: Da Silva Michael 
Published: March 2022

AbstractFederalism has important implications for basic philosophical concepts, including authority and distributive justice. Philosophers played key roles in the development of federalism as a(n at least purportedly) normative doctrine. However, federalism remains peripheral in contemporary political philosophy, leading to periodic calls for renewed scrutiny. This article identifies questions that any complete philosophical account of federalism should aim to answer and provides an overview of some dominant responses to those questions offered in contemporary work in law, political science, and the nascent contemporary philosophical work on the doctrine. It first explains why federalism should be considered philosophically important. It then explores issues about the meaning and purpose, paradigm cases, institutional implications, and subjects/objects of federalism. It finally highlights the need to explain federalism's relationships to adjacent concepts, like democracy, subsidiarity, and self‐determination, and possible links between them.