bluuebunny/crossref_metadata_2025_split huggingface dataset:
Critical review of polymer and hydrogel deposition methods for optical and electrochemical bioanalytical sensors correlated to the sensor’s applicability in real samples
Authors: Bauer Meike , Duerkop Axel , Baeumner Antje J. 
Published: October 2022

AbstractSensors, ranging from in vivo through to single-use systems, employ protective membranes or hydrogels to enhance sample collection or serve as filters, to immobilize or entrap probes or receptors, or to stabilize and enhance a sensor’s lifetime. Furthermore, many applications demand specific requirements such as biocompatibility and non-fouling properties for in vivo applications, or fast and inexpensive mass production capabilities for single-use sensors. We critically evaluated how membrane materials and their deposition methods impact optical and electrochemical systems with special focus on analytical figures of merit and potential toward large-scale production. With some chosen examples, we highlight the fact that often a sensor’s performance relies heavily on the deposition method, even though other methods or materials could in fact improve the sensor. Over the course of the last 5 years, most sensing applications within healthcare diagnostics included glucose, lactate, uric acid, O2, H+ ions, and many specific metabolites and markers. In the case of food safety and environmental monitoring, the choice of analytes was much more comprehensive regarding a variety of natural and synthetic toxicants like bacteria, pesticides, or pollutants and other relevant substances. We conclude that more attention must be paid toward deposition techniques as these may in the end become a major hurdle in a sensor’s likelihood of moving from an academic lab into a real-world product.
Graphical abstract
Examining the synergistic effects of a cognitive control video game and a home-based, self-administered non-invasive brain stimulation on alleviating depression: the DiSCoVeR trial protocol
Authors: Dechantsreiter Esther , Padberg Frank , Morash Alon , Kumpf Ulrike , Nguyen Arthur , Menestrina Zeno , Windel Fabienne , Burkhardt Gerrit , Goerigk Stephan , Morishita Takuya , Soldini Aldo , Ahissar Shira , Cohen Tamar , Pasqualotto Angela , Rubene Linda , Konosonoka Liene , Keeser Daniel , Zill Peter , Assi Razan , Gardier Rémy , Viñals Roser , Thiran Jean-Philippe , Segman Ronen , Benjamini Yuval , Bonne Omer , Hummel Friedhelm Christoph , Bavelier Daphne , Rancans Elmars , Nahum Mor 
Published: October 2022

AbstractEnhanced behavioral interventions are gaining increasing interest as innovative treatment strategies for major depressive disorder (MDD). In this study protocol, we propose to examine the synergistic effects of a self-administered home-treatment, encompassing transcranial direct current stimulation (tDCS) along with a video game based training of attentional control. The study is designed as a two-arm, double-blind, randomized and placebo-controlled multi-center trial (ClinicalTrials.gov: NCT04953208). At three study sites (Israel, Latvia, and Germany), 114 patients with a primary diagnosis of MDD undergo 6 weeks of intervention (30 × 30 min sessions). Patients assigned to the intervention group receive active tDCS (anode F3 and cathode F4; 2 mA intensity) and an action-like video game, while those assigned to the control group receive sham tDCS along with a control video game. An electrode-positioning algorithm is used to standardize tDCS electrode positioning. Participants perform their designated treatment at the clinical center (sessions 1–5) and continue treatment at home under remote supervision (sessions 6–30). The endpoints are feasibility (primary) and safety, treatment efficacy (secondary, i.e., change of Montgomery-Åsberg Depression Rating Scale (MADRS) scores at week six from baseline, clinical response and remission, measures of social, occupational, and psychological functioning, quality of life, and cognitive control (tertiary). Demonstrating the feasibility, safety, and efficacy of this novel combined intervention could expand the range of available treatments for MDD to neuromodulation enhanced interventions providing cost-effective, easily accessible, and low-risk treatment options.ClinicalTrials.gov: NCT04953208.
The limits to growth: how large can subaqueous, flow-transverse bedforms ultimately become?
Authors: Flemming Burg 
Published: October 2022

AbstractBased on field and experimental evidence, the average initial spacing (seed wavelength) of flow-transverse bedforms (ripples and dunes) appears to lie between 80 and 130 grain diameters (L = 80–130Dmm). Starting with an average initial spacing of L = 100Dmm, subsequent bedform growth proceeds by amalgamation of two successive bedforms, which results in a doubling of the spacing in each step. Geometric principles dictate that the combined volume of two smaller bedforms lacks about 40% of the volume required for a fully developed amalgamated bedform. The missing volume is gained by excavation of the troughs, i.e., by lowering the base level. Where base level lowering is prevented by the presence of a coarse-grained armor layer or hard ground pavement, the larger amalgamated bedform remains sediment starved. In its simplest form, bedform growth proceeds by continuous doubling of the spacing in response to increases in flow velocity, the process being reversible in response to flow decelerations. Bedform growth terminates when the shear velocity (u*) at the crest reaches the mean settling velocity (ws) of the sediment. At this point, 40% of the bed material is in suspension, at which point the missing volume can no longer be compensated by trough excavation. In shallow water, maximum bedform size is dictated by the water depth, whereas in deep water, bedforms can potentially grow to their ultimate size. Evaluation of bedform data from deep water settings suggests that the largest two-dimensional, flow-transverse bedforms in terms of grain size (phi) can be approximated by the equations: lnLmax = 13.72–4.03Dphi and lnHmax = 9.95–3.47Dphi for grain sizes <  ~ 0.2 mm (> ~ 2.32 phi), with L and H representing bedform spacing and height in meters and D the grain size in phi. For grain sizes >  ~ 0.2 mm (< ~ 3.23 phi), the corresponding relationships are lnLmax = 6.215–0.69 Dphi and lnHmax = 3.18–0.56Dphi, with notations as before, or in terms of grain diameters in mm: Lmax = 5 × 105Dmm.
Implementation of Lost & Found, An Intervention to Reengage Patients Out of HIV Care: A Convergent Explanatory Sequential Mixed-Methods Analysis
Authors: Linthwaite Blake , Kronfli Nadine , Lessard David , Engler Kim , Ruppenthal Luciana , Bourbonnière Emilie , Obas Nancy , Brown Melodie , Lebouché Bertrand , Cox Joseph ,   the CVIS clinical team
Published: October 2022

AbstractBeing out of HIV care (OOC) is associated with increased morbidity and mortality. We assessed implementation of Lost & Found, a clinic-based intervention to reengage OOC patients. OOC patients were identified using a nurse-validated, real-time OOC list within the electronic medical records (EMR) system. Nurses called OOC patients. Implementation occurred at the McGill University Health Centre from April 2018 to 2019. Results from questionnaires to nurses showed elevated scores for implementation outcomes throughout, but with lower, more variable scores during pre-implementation to month 3 [e.g., adoption subscales (scale: 1–5): range from pre-implementation to month 3, 3.7–4.9; thereafter, 4.2–4.9]. Qualitative results from focus groups with nurses were consistent with observed quantitative trends. Barriers concerning the EMR and nursing staff shortages explained reductions in fidelity. Strategies for overcoming barriers to implementation were crucial in early months of implementation. Intervention compatibility, information systems support, as well as nurses’ team processes, knowledge, and skills facilitated implementation.
Short-time cold atmospheric pressure plasma exposure can kill all life stages of the poultry red mite, Dermanyssus gallinae, under laboratory conditions
Authors: Rüster Vanessa , Werner Henrik , Wieneke Stephan , Avramidis Georg , ten Bosch Lars , Krause Eike Tobias , Strube Christina , Bartels Thomas 
Published: October 2022

AbstractIn the present study, the acaricidal effects of cold atmospheric pressure plasma treatment on poultry red mites of different developmental stages have been investigated under laboratory conditions using a dielectric barrier discharge system. A total of 1890 poultry red mites and 90 mite eggs, respectively, were exposed to the plasma under various parameter settings with a single plasma pulse generated using the gas mixture of the ambient air at atmospheric pressure. The results showed that all developmental stages of the poultry red mite could be killed by cold atmospheric pressure plasma treatment. Plasma exposure to mite eggs resulted in a complete 100% hatch inhibition regardless of the parameter settings. Post-exposure mortality rates of larvae, nymphs and adults showed significant differences after utilization of plasma at 10 W for 1.0 s. In addition, the mortality rate increased with progressing time after plasma exposure. An average mortality rate of 99.7% was observed after 12 h in all mites exposed to plasma, regardless of the selected plasma parameter, developmental stage, and nutritional status of the mites. Cold atmospheric pressure plasma has an acaricidal effect on all developmental stages of Dermanyssus gallinae, suggesting that it could be developed to an effective method for the control of poultry red mites in laying hen husbandry.
Long-term preserved mycelium establishes the presence of Cryphonectria carpinicola in the Balkans and of Cryphonectria radicalis in Bulgaria
Authors: Cornejo Carolina , Risteski Mihajlo , Sotirovski Kiril , Rigling Daniel 
Published: October 2022

AbstractAround the world, isolate collections in mycological institutes have long preserved valuable specimens and information for science. In the present study, we determine Cryphonectria-like taxonomic rarities in our 10–24 years old isolate collection from the Balkans to link preserved dry mycelium with DNA data. Using ITS sequences, we confirm for the first time the occurrence of Cryphonectria carpinicola on a Carpinus tree in the Balkans and extend the range of Cryphonectria radicalis found on Castanea sativa to Bulgaria. The oldest specimen examined dates from 1998 and molecularly confirms the first reported finding of Cryphonectria radicalis for North Macedonia.
Recent advances in graves ophthalmopathy medical therapy: a comprehensive literature review
Authors: Li Xueting , Li Senmao , Fan Wanlin , Rokohl Alexander C. , Ju Sitong , Ju Xiaojun , Guo Yongwei , Heindl Ludwig M. 
Published: October 2022

AbstractGraves ophthalmopathy (GO), which occurs in autoimmune thyroid disease, can reduce patients’ quality of life due to its impact on visual function, physical appearance, and emotional health. Corticosteroids have been the first-line treatment for GO. More recently, the pathogenesis of GO has made significant progress. Various targeting biological agents and immunosuppressive agents make GO management more promising. Fully understanding GO pathogenesis and precise clinical management are beneficial for the prognosis of patients. Therefore, we conducted a comprehensive review of the medical management of GO and summarized research developments to highlight future research issues.
Complex group rings and group C$$^*$$-algebras of group extensions
Authors: Öinert Johan , Wagner Stefan 
Published: October 2022

AbstractLet N and H be groups, and let G be an extension of H by N. In this article, we describe the structure of the complex group ring of G in terms of data associated with N and H. In particular, we present conditions on the building blocks N and H guaranteeing that G satisfies the zero-divisor and idempotent conjectures. Moreover, for central extensions involving amenable groups we present conditions on the building blocks guaranteeing that the Kadison–Kaplansky conjecture holds for the group C$$^*$$

∗

-algebra of G.
Socioeconomic and Medical Vulnerabilities Among Syrian Refugees with Non-communicable Diseases Attending Médecins Sans Frontières Services in Irbid, Jordan
Authors: Carrion-Martin Antonio Isidro , Alrawashdeh Ahmad , Karapanagos Georgios , Mahmoud Refqi , Ta’anii Nashaat , Hawari Mais , Dittmann Stefanie , Hammad Luna , Huisman Geertje , Sherlock Mark , Reddy Amulya 
Published: October 2022

AbstractNon-communicable diseases (NCDs) are high-prevalence health problems among Syrian refugees. In 2014, Médecins Sans Frontières (MSF) identified unmet NCD care needs and began providing free-of-charge services for Syrian refugees in Irbid, Jordan. This study aimed to describe current socioeconomic and medical vulnerabilities among MSF Irbid Syrian refugee patients and their households and raise awareness of their ongoing health needs that must be addressed. A cross-sectional survey among Syrian refugees attending MSF NCD services in Irbid Governorate, Jordan was conducted by telephone interviews in January 2021 to query sociodemographic characteristics, economic situation, self-reported NCD prevalence, and Ministry of Health (MoH) policy awareness. Descriptive analysis of indicators included proportions or means presented with 95% confidence intervals. The survey included 350 patient-participants in 350 households and 2157 household members. Mean age was 28.3 years. Only 13.5% of household members had paid or self-employed work; 44% of households had no working members. Mean monthly income was 258.3 JOD (95%CI: 243.5–273.1) per household. Mean expenditures were 320.0 JOD (95%CI: 305.1–334.9). Debt was reported by 93% of households. NCD prevalence among adults was 42% (95%CI: 40–45). Hypertension was most prevalent (31.1%, 95%CI: 28.7–33.7), followed by diabetes (21.8%, 95%CI: 19.7–24.1) and cardiovascular diseases (14.4%, 95%CI: 12.6–16.4). Only 23% of interviewees were aware of subsidized MoH rates for NCD care. Twenty-nine percent stated they will not seek MoH care, mainly due to the unaffordable price. Our findings highlight increased vulnerability among MSF Irbid Syrian refugee NCD patients and their households, including: an older population; a high percentage of unemployment and reliance on cash assistance; higher proportion of households in debt and a high number of households having to resort to extreme coping mechanisms when facing a health emergency; and a higher proportion of people with multiple comorbid NCDs and physical disability. Their awareness of subsidised MoH care was low. MoH care is expected to be unaffordable for many. These people are at increased risk of morbidity and mortality. It is vital that health actors providing care for Syrian refugees take action to reduce their risk, including implementing financial support mechanisms and free healthcare.
Teaching automation with Factory I/O under a competency-based curriculum
Authors: Vargas Hector , Heradio Ruben , Donoso Matias , Farias Gonzalo 
Published: October 2022

AbstractSome of the most critical competencies students need to acquire to become control engineers require performing practices under actual industrial conditions. This means that they must not only master the theoretical aspects of the discipline but also acquire skills and attitudes to face unpredictable real-world situations. Software tools such as Matlab/Simulink are widely used to train the design and validation of controllers, but they fail to provide real industrial contexts. Nowadays, there are 3D simulation tools that support recreating industrial environments to a remarkable extent, making them very attractive for university courses. Nevertheless, their application in engineering courses is scarce yet. This paper presents a methodological framework for seizing into competency-based courses one of these simulation tools, called Factory I/O. Our approach was evaluated in a master’s course on Industrial PID Control at Pontifical Catholic University of Valparaíso (PUCV) in Chile. The evaluation comprised the qualitative analysis of students’ grades over four consecutive course editions and the qualitative study of students’ opinion on Factory I/O educational value. The objectives of our evaluation were (i) testing if Factory I/O helped students develop skills hard to practice in academic contexts, such as detecting faults or recognizing the importance of having well-defined operation protocols; (ii) validating our methodology for competency-based courses; and (iii) surveying our students about Matlab/Simulink and Factory I/O strengths/weaknesses to teach control engineering. According to the results, (a) Factory I/O complements Simulink by providing an adequate virtual environment to learn the aforementioned skills; and (b) our methodology supports courses’ continuous improvement through the statistical analysis of students’ achievements at different abstraction levels.
Analysis of material susceptibility in silicon on insulator waveguides with combined simulation of four-wave mixing and linear mode coupling
Authors: Höfler Ulrike , Kernetzky Tasnad , Hanik Norbert 
Published: October 2022

AbstractWe derive propagation equations modeling third-order susceptibility-induced nonlinear interaction and linear mode coupling in waveguides. We model material susceptibility with Raman and electronic response which include approximations suited for optical communications. We validate our model by comparing numerical integration of the propagation equations to continuous wave measurements of a silicon on insulator waveguide.
Stuck in between. Phenomenology’s Explanatory Dilemma and its Role in Experimental Practice
Authors: Casper Mark-Oliver , Haueis Philipp 
Published: October 2022

AbstractQuestions about phenomenology’s role in non-philosophical disciplines gained renewed attention. While we claim that phenomenology makes indispensable, unique contributions to different domains of scientific practice such as concept formation, experimental design, and data collection, we also contend that when it comes to explanation, phenomenological approaches face a dilemma. Either phenomenological attempts to explain conscious phenomena do not satisfy a central constraint on explanations, i.e. the asymmetry between explanans and explanandum, or they satisfy this explanatory asymmetry only by largely merging with non-phenomenological explanation types. The consequence of this dilemma is that insofar as phenomenological approaches are explanatory, they do not provide an own type of explanation. We substantiate our two claims by offering three case studies of phenomenologically inspired experiments in cognitive science. Each case study points out a specific phenomenological contribution to experimental practice while also illustrating how phenomenological approaches face the explanatory dilemma we outline.
Does ageing make life simpler? The dynamics, covariates, and implications of complexity of time-use patterns in late adulthood
Authors: Jarosz Ewa 
Published: October 2022

AbstractAgeing affects individuals’ daily behaviours. Functional and social limitations increase, while the pool of possible activities and individuals’ ability to switch between tasks decline. If older adults lose ability to perform certain activities and do not substitute them with others, the complexity of their daily time-use sequences will decline. Studies show that having less complex behaviours and being in less complex environments are associated with poorer cognitive performance, worse intellectual functioning, and lower wellbeing. This study looks at complexity of everyday time-use patterns of older adults, aged 65 and above. A pooled sample of 25,495 time-use diaries came from four nationally representative time-use surveys: German (2012/2013), Polish (2013/2014), Finnish (2009/2010), and British (2014/2015). Using multivariable linear regression we investigated how complexity was related to individuals’ age, gender, education and income, area of residence, household composition, and disability status. Complexity generally declined in later life but its mean levels and the steepness of this decline differed across countries. Controlling for age, complexity was significantly lower for men and lower-educated individuals, as well as for individuals with disabilities and those living in larger households. Most older adults want to live rich and engaged lives. Individuals having significantly less complex sequences may be at an increased risk of functional, cognitive or social decline, and lower overall wellbeing. Looking at sequence complexity may offer unique insight into older adults’ overall functioning in later life.
The interaction mechanism of cesium with water on the SrTiO3(100) surface at room temperature
Authors: Kamaratos Mattheos , Giotopoulou Εleftheria , Vlachos Dimitrios 
Published: October 2022

AbstractThe interaction of water with cesium on the strontium titanate surface SrTiO3(100), was studied, mainly by means of work function measurements and thermal desorption spectroscopy. The catalytic role of cesium with respect to the dissociation of water on surface was investigated, by applying two different adsorption processes at room temperature (RT): (1) The adsorption of water on the cesium covered surface (sequential adsorption), and (2) the co-adsorption process (simultaneous adsorption) on surface. Based on the results and by adopting the Lewis acid–base model, we conclude that during the sequential adsorption the water molecules are mostly adsorbs non-dissociatively on surface, without oxidizing the alkaline overlayer. This seems to be due, first to the strong interaction between the alkaline adatoms and the substrate, and secondly to the limited maximum pre-deposited amount of cesium (≤ 0.45 ML). Instead, water dissociation appears to merely occur on defective sites of the substrate in accordance with previous studies. For a full cesium layer covered surface, the adsorbed water retracts the metallicity of cesium due to electrostatic interactions. In contrast to the sequential adsorption, during the co-adsorption process the oxidation of cesium takes place above a critical coverage of cesium (≥ 0.45 ML). It appears that the co-adsorbed cesium with water modifies the surface potential providing an effective template for cesium oxide, Cs2O development. Based on that, we suggest a catalytic reaction of water dissociation according to the Langmuir–Hinshelwood mechanism. Finally, we propose atomistic adsorption models for both processes of cesium with water adsorption.
Technology-driven surrogates and the perils of epistemic misalignment: an analysis in contemporary microbiome science
Authors: Suárez Javier , Boem Federico 
Published: October 2022

AbstractA general view in philosophy of science says that the appropriateness of an object to act as a surrogate depends on the user’s decision to utilize it as such. This paper challenges this claim by examining the role of surrogative reasoning in high-throughput sequencing technologies (technology-driven surrogates) as they are used in contemporary microbiome science. Drawing on this, we argue that, in technology-driven surrogates, knowledge about the type of inference practically permitted and epistemically justified by the surrogate constrains their use and thus puts a limit to the user’s intentions to use any object as a surrogate for what they please. Ignoring this leads to a serious epistemic misalignment, which ultimately prevents surrogative reasoning. Thus, we conclude that knowledge about the type of surrogate reasoning that the technologies being used allow is fundamental to avoid misinterpreting the consequences of the data obtained with them, the hypothesis this data supports, and what these technologies are surrogates of.