bluuebunny/crossref_metadata_2025_split huggingface dataset:
YWHAG promotes gastric cancer proliferation and migration via PI3K/AKT pathway
Authors: Yanmei Gu , Daijun Wang , Xiaomei Li , Yingying Wang , Meixia Deng , Li Yumin 
Published: March 2022

Abstract
Background: The influence of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma (YWHAG) remains unknown in gastric cancer (GC). We investigated biological effects of YWHAG on GC and clarified the potential molecular mechanisms.Methods: YWHAG expression in GC was assessed by immunohistochemistry, followed by correlation analysis. GC cells of YWHAG knockdown and overexpression­ were constructed by lentivirus transfection. Cell viability of growth was evaluated by cell counting kit-8 (CCK8) and the 5-ethyny-2-deoxyuridine (EdU) assays. Cell cycle and apoptosis were conducted. The following migration and invasion analysis were detected by wound-healing and trans-well assays. The role of YWHAG in vivo was revealed by xenograft models. Gene set enrichment analysis (GSEA) and western blotting were applied for the potential pathways. Results: YWHAG was elevated in GC (p<0.05), and closely related to differentiation degree. The study demonstrated that YWHAG knockdown significantly inhibited the proliferation, migration, invasion and epithelial-mesenchymal transformation (EMT) of GC cells and decelerated the growth of xenograft tumors, while YWHAG overexpression reversed the effects. Consistent with the results of GSEA, YWHAG activated PI3K/AKT pathway. Conclusions: YWHAG can promote proliferation and migration of GC, which might be related to the cell cycle, EMT and PI3K/AKT signaling pathway.
Nectarine Disease Detection based on Color Features and Label Sparse Dictionary Learning with Hyperspectral Images
Authors: miao ronghui , Jinlong Wu , Hua Yang , Fenghua Huang 
Published: March 2022

Abstract
Fruit cracking and rust spot are common diseases of nectarine which would seriously affect its yield and quality. Therefore, it is essential to construct disease detection models for agricultural products with high speed and accuracy. In this paper, a sparse dictionary learning method was proposed to realize the rapid and nondestructive detection of nectarine disease based on the multiple color features combined with the improved K-SVD (K-Singular Value Decomposition). According to the color characteristics of nectarine itself and the significant color differences existing in the three categories of nectarine (diseased, normal and background parts), multiple color spaces of RGB, HSV, Lab and YCbCr were studied. It was concluded that the G channel in RGB space, Y channel in YCbCr space and L channel in Lab space can better distinguish the diseased part from the other parts. At the model training stage, pixels of the diseased, normal and background parts in the nectarine image were randomly selected as the initial training sets, then the neighborhood image block of the pixels were selected to construct the feature vectors based on the above color space channels. An improved LK-SVD (Label K-SVD) dictionary learning algorithm was proposed that integrating the category label into the process of dictionary learning, then an over-complete feature dictionary with significant discrimination was obtained. At the model testing stage, orthogonal matching pursuit (OMP) algorithm was used to sparse reconstruction the original data which can obtain the classification categories based on the optimized feature dictionary. Experimental results show that the sparse dictionary learning method based on multi-color features combined with improved LK-SVD can detect fruit cracking and rust spot diseases of nectarine quickly and accurately, and the average overall classification accuracies were 92.06% and 88.98% respectively, which was better than k-nearest neighbor (KNN) and support vector machine (SVM). It is demonstrated that this study can provide technical support for the diseases detection of agricultural products.
Feasibility Study of Functional Movement Screening in Drug Abuse Population
Authors: Yan Hanhui , Wang Jingsong , Guo Yin , Tan Jun , Lu Chunxia , Liu Yi , Zhang Jun , Zheng Lan 
Published: March 2022

Abstract
Objective: To investigate the feasibility of functional movement screening (FMS) in drug abuse patients and to evaluate the relationship between functional motor ability and age, sex and drug type. Methods: Random sampling was used to include 886 drug abusers from 5 provinces. The FMS test was conducted on 886 patients in compulsory isolation drug rehabilitation centers in five provinces of China, and the statistics were calculated. Results: The FMS scores of the psychotropic drugs group were all lower than that of the narcotic drugs group, especially in the core stability items (P < 0.01). Men scored higher than women in core stability and lower than women in flexibility. The seven FMS scores of the 30-34 years old group were lower than those of 35-49 years old and 40-44 years old groups, respectively. The total FMS scores were significantly correlated with gender (r=0.198, P < 0.01), age (r=0.161, P < 0.01) and drug type (r=0.283, P < 0.01).Conclusions: The application of FMS in the drug abuse population is viable, and drug type, sex and age can be used to predict the FMS composite score.
Evaluation and Projections of Surface Air Temperature over the Tibetan Plateau from CMIP6 and CMIP5: Warming Trend and Uncertainty
Authors: Zhou Minpei , Yu Zhongbo , Gu Huanghe , Ju Qin , Gao Yiyan , Wen Lei , Huang Tangkai 
Published: March 2022

Abstract
This paper compares the historical simulations and future projections of surface air temperature over the Tibetan Plateau of the updated Coupled Model Intercomparison Project phase (CMIP6) and the precedent phase of the project (CMIP5) to quantify differences in the projections under different scenarios. Model evaluation for the historical period (1961-2005) indicates that the multi-model ensemble (MME) mean of CMIP6 outperforms CMIP5 MME in simulating spatial-temporal characteristics of surface air temperature. The temperature changes relative to 1986-2005 are projected in the near-term (2021-2040), mid-term (2041-2060), and long-term (2081-2100) future under Shared Socio-economic Pathway (SSP)2-4.5 and SSP5-8.5 of CMIP6 and Representative Concentration Pathway (RCP)4.5 and RCP8.5 of CMIP5. The projected temperature shows larger increases in the long-term compared with the near-term and mid-term under both SSPs and RCPs. CMIP6 MME projects higher temperature changes and accelerated warming trends relative to CMIP5 MME. Additionally, the temperature increases and warming rates show a significant elevation dependency, especially in the long-term. The uncertainty for future projections is quantified by the square root of error variance (SREV) method. The results record a clear reduction in the uncertainty of CMIP6 temperature relative to CMIP5 primarily concentrated at the elevation zones of over 5,000 m. The analysis of the projected temperature over the Tibetan Plateau is of great significance for policy-makers to make socio-economic adjustments for the future warming. This study is conducive to the credibility of future temperature projections for CMIP6 and enhances our comprehension of the uncertainty of SSP and RCP scenarios.
Green Synthesis Approach For Preparing Zeolite Based Co-Cu Bimetallic Catalysts For Low Temperature CO2 Hydrogenation To Methanol
Authors: Din Israf Ud , Alotaibi Mshari A. , Naeem A. , Alharthi Abdulrahman I. , Al-Shalwi Matar N. , Alshehri Feras 
Published: March 2022

Abstract
In this study, zeolite based Cu-Co bimetallic catalysts were synthesized by green deposition precipitation method. To investigate the optimum metal-metal ratio, catalysts with different Cu-Co metal weigh ratios were studied. XRD analysis revealed deposition of highly dispersed Cu-Co metal oxides on the surface of zeolite support. The nitrogen adsorption-desorption studies showed that surface area of Cu-Co bimetallic catalysts was slightly decreased by increasing Cu content in bimetallic catalysts. Temperature program reduction studies exhibited synergism between the Cu-Co metals which resulted variation in reduction behavior of zeolite based bimetallic catalysts. Temperature program desorption investigations showed the existence of three types of basic sites on the surface of zeolite based Cu-Co bimetallic catalysts. Activity profiles of zeolite based Cu-Co bimetallic catalysts were examined for low temperature CO2 hydrogenation to methanol in slurry reactor. The activity studies documented enhancement in methanol synthesis rate from 7.5 to 25. 6 g/Kgcat. h by increasing the Cu content in catalysts. Based on the physico-chemicals findings and activity data, structure-activity patterns were elaborated in details.
The incidence, risk factors and outcomes of impaired cerebral autoregulation in aortic arch surgery: a single-center, retrospective cohort study
Authors: Peng Ling , Guo Dan , Shi Yinhui , Yang Jiapei , Wei Wei 
Published: March 2022

Abstract
Backgroundː Impairment of cerebral autoregulation (CA) has been observed in patients undergoing cardiopulmonary bypass (CPB), but little is known about its risks and associations with outcomes. The objective of this study was to analyze the incidence and risks of impaired CA, based on cerebral oximetry index (COx), in patients undergoing total aortic arch replacement with CPB and moderate hypothermic circulatory arrest (MHCA). We also evaluated the association between impaired CA and patient outcomes.Methodsː One hundred fifteen four adult patients who underwent total aortic arch replacement with stented elephant trunk implantation under CPB and MHCA at our hospital were retrospectively analyzed. Patients were defined as having new-onset impaired CA if post-CPB COx > 0.3, calculated based on a moving linear correlation coefficient between regional cerebral oxygen saturation (rScO2) and mean blood pressure (MAP). Pre- and intraoperative factors were tested for independent association with impaired CA. Postoperative outcomes were compared between patients with normal and impaired CA.Resultsː In our 154 patients, 46(29.9%) developed new-onset impaired CA after CPB with MHCA. Multivariate analysis revealed a prolonged low rScO2 (rScO2 <55%) independently associated with onset of impaired CA, and receiver operating charactoristic curve showed a cutoff value at 40 min (sensitivity, 89.5%; specificity, 68.0%). Compared with normal CA patients, those with impaired CA showed a significantly higher rates of in-hospital mortality and postoperative complications.Conclusionː Prolonged low rScO2 (rScO2 <55%) during aortic arch surgery was closely related to onset of impaired CA. Impaired CA remained associated with the increased rates of postoperative complications and in-hospital mortality.Trial registration: ChiCTR1800014545 with registered date 20/01/2018.
Toxicity Ranking of European Industrial Facilities
Authors: Erhart Szilard , Erhart Kornél 
Published: March 2022

Abstract
Here, we present a methodology to improve environmental assessment of Europe based facilities, industries and regions by linking the European Pollutant Release and Transfer Register and the USEtox, a scientific consensus model for characterizing human and ecotoxicological impacts of chemicals. Such environmental assessment is an increasingly important need in policy and finance. In this paper we measure human, cancer and non-cancer toxicity and ecotoxicity risks of more than 10,000 companies from point source pollutant releases in Europe from 2007 to 2017. We discuss water and air emissions of dozens of pollutants in urban, rural, coastal and inland areas. There are clusters of toxicity in the most industrialized regions of North-England, North-Italy, the German Ruhr-area, South-Poland, in the Benelux states, and in coastal areas of Spain, Portugal and Nordic countries. There is an overlap of areas of the largest emissions of human toxicity and ecotoxicity. We confirm toxicity potential of major pollutants in previous research papers (Hg accounting for 71% of the total human toxicity and Zn accounting for 55% of total ecotoxicity). Human toxicity is estimated to be mostly non-cancer type in Europe. Companies in the electricity production sector are estimated to have the largest human toxicity potential (52% of total) in the European Union 2017 and companies in the sewerage sector have the largest ecotoxicity impact potential (41%). Total human toxicity almost halved from 2001 to 2017, although the downward trend reversed in 2016. Ecotoxicity increased by 20% in the same period. A key advantage of our methodology and indicators is that they can be used to measure progress towards the United Nation's Sustainable Development Goals and the environmental objectives in the EU Taxonomy regulation on the company facility level and regionally.
Effects of Autologous Platelet-Rich Fibrin (PRF) Therapy on Wound Healing in Dogs
Authors: Soares Carla S. , Dias Isabel R. , Pires Maria A. , Carvalho Pedro P. 
Published: March 2022

Abstract
Background: Platelet-rich fibrin (PRF), also recognized as leukocyte-rich-PRF, is a recent platelet-based biomaterial, pointed as an innovative regenerative strategy for the treatment of wounds, from different etiologies. This study aimed to evaluate the efficacy of autologous PRF as a regenerative therapy for the treatment of skin wounds of multiple etiology, in dogs. The authors postulated that autologous PRFs could be successfully used as a biocompatible patch to increase the physiologic wound regeneration, acting as a biological antiseptic biomaterial, in spontaneous open large or chronic wounds in dogs. Eight dogs, aged between 7-months to 9-year-old, with naturally occurring cutaneous wounds were enrolled in this study. Four of these wounds were infected. The PRF treatment was initially performed two times per week, followed by single weekly treatments from the second week onwards, until exophytic granulation tissue was present. The study was finalized when complete wound closure was achieved. Results: PRF grafting treatments were well tolerated in all treated wounds, inducing significant granulation tissue formation. PRF clots acted as a natural tissue-filler, promoting the epithelization and wound closure, without the requirement of topical antimicrobial/antiseptics application, or additional debridement. Evident skin contraction was recorded in larger injuries and all the treatments resulted in vestigial aesthetic scars.Conclusions: The PRF therapy constitutes a promising regenerative treatment, accelerating the natural healing process.
Evaluation of the Mutagenic and Antimutagenic Activity of Chlorella Vulgaris in a Test of Allium Cepa
Authors: Messias Inalda Maria de Oliveira , Beltrão Gerusa Tomaz  de Aquino , Oliveira Giselly Thais da Silva , de Andrade Lúcio Arantes , Silva Silvana de Fátima Ferreira da , Messias Júlio Brando , Ferreira Adriano Gomes , Bezerra Raquel Pedrosa , Marques Daniela Araújo Viana , Porto Ana Lúcia Figueiredo 
Published: March 2022

Abstract
The microalgae Chlorella vulgaris is usually commercialized as nutraceutical althoughit has potential application in the pharmaceutical and cosmetic industries. Therefore, our objective in this research is to evaluate the mutagenic and antimutagenic action of the aqueous extract of Chlorella vulgaris through the Allium cepa assay. Three concentrations of the aqueous extract of Chlorella vulgaris were tested: 0.075, 0.15 and 0.30mg/mL. In the mutagenicity analysis, Allium cepa meristematic cells were cultured in the presence of the aqueous extract of Chlorella vulgaris with distilled water as negative control and copper sulfate as positive control. For antimutagenicity, pre-treatment, simple simultaneous and post-treatment protocols were used. 400 cells/treatment were analyzed under optical microscopy (40x). Data were analyzed by ANOVA (one-way) and Tukey tests, considering p < 0.05. The aqueous extract of Chlorella vulgaris did not show mutagenicity in any of the three concentrations evaluated. About the antimutagenicity protocols, the harm reduction percentages were 94.7%, 94.1% and 96.2% (pre-treatment); 88.9%, 93.2% and 91.08% (simultaneous simple); and 85.2%, 84.5% and 94.7% (post-treatment) referring to concentrations of 0.075, 0.15 and 0.30 mg/mL, respectively. According to these results, the microalgae Chlorella vulgaris did not show mutagenic action at the tested doses and it reduced genetic damage caused by copper sulfate.
Antifungal Activities of Artesunate, Chloramphenicol, and Co-trimoxazole in Comparison to Standard Antifungal Agents against Basidiobolus Species
Authors: Al-Qahtani Saleh M. , Joseph Martin R.P. , Al-Hakami Ahmed M. , Asseri Ali A. , Shati Ayed A. , Mathew Anjali , Bshabshe Ali Al , Alhumayed Suliman , Hamid Mohamed E. 
Published: March 2022

Abstract
Background: Basidiobolomycosis, which is caused by pathogenic Basidiobolus species, is a rare fungal infection affecting the skin and gastrointestinal tract, which is mainly reported from tropical and subtropical regions. There is evidence that 'unconventional' antifungal drugs affect some fungal species. The current study intended to assess the in vitro effect of non-antifungal drugs, namely, artesunate, chloramphenicol, and co-trimoxazole in comparison to amphotericin B, fluconazole, itraconazole, metronidazole, and voriconazoleon in comparison to amphotericin B, fluconazole, itraconazole, metronidazole, and voriconazoleon on representative medically significant fungi. Methods: Basidiobolus species (n =13) isolated from human gastrointestinal basidiobolomycosis and lizards were tested against artesunate, chloramphenicol, and co-trimoxazole. The antimicrobial assay was done using the agar diffusion method. The broth microdilution method was performed with a two-fold serial dilution of each antimicrobial agent to determine the minimum inhibitory concentration (MIC). The nonparametric Wilcoxon Signed Rank Test. analyzed the mean difference between inhibitory measures between the drugs. Results: The three agents exhibited inhibitory actions against Basidiobolus species comparable to the known antifungals. The combined effects of artesunate + voriconazole and co-trimoxazole + voriconazole have significant synergic effects, p = 0.003 and p = 0.021, respectively. Conclusions: This study showed that non-antifungal agents were active against Basidiobolus species. These are promising results that enhance the accelerated combined treatment of GIB in humans, particularly the combination of artesunate and voriconazole.
Spatiotemporal Change in Groundwater Sustainability of Bangladesh for the Period 1995-2019
Authors: Fahim Abul Kashem Faruki , Kamal A S M Maksud , Shahid Shamsuddin 
Published: March 2022

Abstract
Groundwater is gradually becoming scarce in Bangladesh like many other countries around the globe due to various climatic, hydrological, and socio-economic changes. This study aimed to assess the spatiotemporal changes in groundwater availability and sustainability in Bangladesh. The study employed weekly groundwater table (GWT) data from 844 groundwater observation wells of the Bangladesh Water Development Board (BWDB) from 1995 to 2019. Mann-Kendall (M-K) test at 95% significance level and the Sen's slope estimator were used to assess the spatiotemporal variations in GWT, and the reliability-resiliency-vulnerability (RRV) approach was applied for evaluating sustainability. In addition, the yearly trends in RRV indicators and sustainability were estimated. The results revealed the mean GWT is low in the northwest and central regions. The GWT is declining almost all over the country, particularly in the areas where it is already low by 0.548-1.398 m/year. The groundwater showed remarkably poor sustainability for most of the areas. It also showed a declining trend over a large area in the central north. The analysis of results through the scrutiny of irrigated land and population distribution of the country revealed higher abstraction of groundwater for irrigation and domestic supply are the major cause of declining GWT in the northwest and central regions of the country. The study provided an understanding of the changes in groundwater and its sustainability which can be used as a guide for sustainable management of groundwater and contribute to drawing up future groundwater policies.
Using AFR+PNI Model for Predicting Disease Activity in Patients With Systemic Lupus Erythematosus
Authors: Luo Qing , Zhao Hongshuai , Fu Peng , Xiao Qiuyun , Fu Biqi , Guo Yang , Huang Qingshui , Huang Zikun , Li Junming 
Published: March 2022

Abstract
Background: Systemic lupus erythematosus (SLE) is chronic autoimmune disease with multiple organ damage and is associated with poor prognosis and high mortality. Identification of universal biomarkers to predict SLE activity is challenging due to the heterogeneity of the disease. This study aimed to identify the indicators that are sensitive and specific to predict activity of SLE. Methods: We retrospectively analyzed 108 patients with SLE. Patients were categorized into SLE with activity and without activity groups on the basis of SLE disease activity index. We analyzed the potential of routine and novel indicators in predicting the SLE activity using receiver operating characteristic curves and multivariate logistic regression. The Spearman method was used to understand the correlation between albumin to fibrinogen ratio (AFR), prognostic nutritional index (PNI), AFR+PNI model and disease activity.Results: SLE with activity group had elevatory C3, ESR, CRP, D-dimer, fibrinogen, CRP to albumin ratio, positive rate of anti-dsDNA and ANUA, lower TBIL, TP, albumin, albumin/globulin, creatinine, HDL-C, hemoglobin, hematocrit, lymphocyte count, AFR, PNI. A further established model based on combination of AFR and PNI (AFR-PNI model) showed prominent value in distinguishing SLE with activity patients from SLE without activity patients. In addition, the sensitivity and specificity of AFR-PNI model +anti-dsDNA combination model were superior to AFR-PNI model. AFR and PNI were risk factors for SLE activity. Moreocer, AFR, PNI and AFR+PNI model correlated with disease activity. Furthermore, AFR, PNI, and AFR-PNI model were associated with fever, pleurisy, pericarditis, renal involvement. Conclusion: These findings suggest that predictive model based on combination of AFR and PNI may be useful markers to identify active SLE in clinical practice.
Tetracycline Adsorption on Magnetic Sludge Biochar: Effects of pH and Natural Organic Matters
Authors: Wu Yuanhui , Long Dan , Yang Fanian , Luo Suxing 
Published: March 2022

Abstract
Natural organic matters (NOM) are ubiquitous in the environment, but few systematic studies have examined the influence of NOM on the sorption ability of magnetic sludge biochar. In this study, magnetic sludge biochar was synthesized, characterized, and used as a sorbent for the removal of tetracycline (TC) from aqueous solutions. The effects of pH, humic acid (HA) and fulvic acid (FA) on TC adsorption by magnetic sludge biochar were studied using batch experiments. Adding HA and FA would alter adsorption behavior of TC, except its pH dependency. Results showed that relatively low concentration of dissolved HA (≤ 8 ppm) and FA(≤ 5 ppm) promoted the adsorption capacity of TC, but higher concentration competed against TC for sorption sites on surface of magnetic sludge biochar. The results of this study promote a better understanding the application of magnetic sludge biochar in real antibiotic wastewater.