bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal soybean genistein on prevention of later-life breast cancer through inherited epigenetic regulations
Authors: Chen Min , Li Shizhao , Srinivasasainagendra Vinodh , Sharma Manvi , Li Zhenhai , Tiwari Hemant , Tollefsbol Trygve O , Li Yuanyuan 
Published: January 2022

AbstractBreast cancer has strong developmental origins and maternal nutrition composition may influence later-life breast cancer risk in the offspring. Our study focused on a bioactive dietary component, genistein (GE) enriched in soybean products, to investigate specific timing of maternal GE exposure that may influence preventive efficacy of GE on offspring breast cancer later in life, and to explore the potential epigenetic mechanisms. Our results indicate a time-dependent effect of maternal GE exposure on early-life breast cancer development in offspring mice. Through integrated transcriptome and methylome analyses, we identified several candidate genes showing significantly differential gene expression and DNA methylation changes. We further found maternal long-term GE treatment can induce inherited epigenetic landmark changes in a candidate tumor suppressor gene, Trp63, resulting in transcriptional activation of Trp63 and induction of the downstream target genes. Our results suggest that maternal long-term exposure to soybean GE may influence early-life epigenetic reprogramming processes, which may contribute to its temporal preventive effects on breast cancer in the offspring. This study provides important mechanistic insights into an appropriate maternal administration of soybean products on prevention of breast cancer later in offspring life.
Predictive factors and prognosis of microscopic residual disease in non-small-cell lung cancer surgery
Authors: Rabinel Pierre , Vergé Romain , Cazaux Mathilde , Mazzoni Lucia , Renaud Claire , Rouch Axel , Brouchet Laurent 
Published: January 2022

Abstract

OBJECTIVES
We described patients with microscopic residual disease (R1) operated on for non-small-cell lung cancer (NSCLC) and investigated predictive factors for R1. We also examined prognostic factors for overall survival in these patients.

METHODS
From June 2003 to December 2019, a total of 2595 patients benefited from an anatomical resection operation for NSCLC in our department. All preoperative data were prospectively collected in Epithor, the French thoracic surgery national database. All pre-, per- and postoperative care followed the current recommendations. Tumours were classified by experienced pathologists according to the TNM classification and the resection status R. Survival information was collected retrospectively using the French national death register.

RESULTS
A total of 94 R1 patients (3.6%) and 2255 R0 patients (86.9%) were identified. R1 patients showed significant differences: They were older (p = 0.02), with a high rate of pneumonectomy(p &lt; 0.001), more squamous cell carcinomas (p &lt; 0.001) and more cases of advanced-stage disease (p &lt; 0.001). We proved that incomplete resection was a poor and independent prognostic factor whereas complete resection had a significant impact on overall survival (HR: 4.66 [3.46–6.27]). Thus, we identified high clinical T status (odds ratio [OR]: 8.82 [5.00–15.56]), high clinical N status (OR: 3.54 [2.13–5.87), squamous cell carcinoma (OR: 3.86 [2.33–6.42]), obesity (OR 1.91 [1.04–3.52]) and low forced expiratory volume in 1 s (OR: 3.62 [1.70–7.68]) as risk factors for R1. No statistical differences were found according to the location of positive resection margin or treatment, whether adjuvant or neoadjuvant.

CONCLUSIONS
Incomplete resection was a poor prognostic factor for overall survival of patients operated on for NSCLC, particularly in the advanced stages of the disease. Identification of different predictive factors should help to avoid this situation.
subj collection: 152
Galectin 3 enhances platelet aggregation and thrombosis via Dectin-1 activation: a translational study
Authors: Chen Yufei , Fu Wanrong , Zheng Yunbo , Yang Jing , Liu Yangyang , Qi Zhiyong , Wu Meiling , Fan Zhichao , Yin Kanhua , Chen Yunfeng , Gao Wen , Ding Zhongren , Dong Jianzeng , Li Qi , Zhang Si , Hu Liang 
Published: January 2022

AbstractAimsGalectin-3, a β-galactoside-binding lectin, is abnormally increased in cardiovascular disease. Plasma Galectin-3 receives a Class II recommendation for heart failure management and has been extensively studied for multiple cellular functions. The direct effects of Galectin-3 on platelet activation remain unclear. This study explores the direct effects of Galectin-3 on platelet activation and thrombosis.Methods and resultsA strong positive correlation between plasma Galectin-3 concentration and platelet aggregation or whole blood thrombus formation was observed in patients with coronary artery disease (CAD). Multiple platelet function studies demonstrated that Galectin-3 directly potentiated platelet activation and in vivo thrombosis. Mechanistic studies using the Dectin-1 inhibitor, laminarin, and Dectin-1−/− mice revealed that Galectin-3 bound to and activated Dectin-1, a receptor not previously reported in platelets, to phosphorylate spleen tyrosine kinase and thus increased Ca2+ influx, protein kinase C activation, and reactive oxygen species production to regulate platelet hyperreactivity. TD139, a Galectin-3 inhibitor in a Phase II clinical trial, concentration dependently suppressed Galectin-3-potentiated platelet activation and inhibited occlusive thrombosis without exacerbating haemorrhage in ApoE−/− mice, which spontaneously developed increased plasma Galectin-3 levels. TD139 also suppressed microvascular thrombosis to protect the heart from myocardial ischaemia–reperfusion injury in ApoE−/− mice.ConclusionGalectin-3 is a novel positive regulator of platelet hyperreactivity and thrombus formation in CAD. As TD139 has potent antithrombotic effects without bleeding risk, Galectin-3 inhibitors may have therapeutic advantages as potential antiplatelet drugs for patients with high plasma Galectin-3 levels.
Improving cardiovascular magnetic resonance access in low- and middle-income countries for cardiomyopathy assessment: rapid cardiovascular magnetic resonance
Authors: Menacho Katia Devorha , Ramirez Sara , Perez Aylen , Dragonetti Laura , Perez de Arenaza Diego , Katekaru Diana , Illatopa Violeta , Munive Sara , Rodriguez Bertha , Shimabukuro Ana , Cupe Kelly , Bansal Rajiv , Bhargava Vivek , Rodriguez Ivonne , Seraphim Andreas , Knott Kris , Abdel-Gadir Amna , Guerrero Salomon , Lazo Marco , Uscamaita David , Rivero Marco , Amaya Neil , Sharma Sanjiv , Peix Amelia , Treibel Thomas , Manisty Charlotte , Mohiddin Sam , Litt Harold , Han Yuchi , Fernandes Juliano , Jacob Ron , Westwood Mark , Ntusi Ntobeko , Herrey Anna , Walker John Malcolm , Moon James 
Published: January 2022

Abstract

Aims
To evaluate the impact of a simplified, rapid cardiovascular magnetic resonance (CMR) protocol embedded in care and supported by a partner education programme on the management of cardiomyopathy (CMP) in low- and middle-income countries (LMICs).

Methods and results
Rapid CMR focused particularly on CMP was implemented in 11 centres, 7 cities, 5 countries, and 3 continents linked to training courses for local professionals. Patients were followed up for 24 months to assess impact. The rate of subsequent adoption was tracked. Five CMR conferences were delivered (920 attendees—potential referrers, radiographers, reporting cardiologists, or radiologists) and five new centres starting CMR. Six hundred and one patients were scanned. Cardiovascular magnetic resonance indications were 24% non-contrast T2* scans [myocardial iron overload (MIO)] and 72% suspected/known cardiomyopathies (including ischaemic and viability). Ninety-eighty per cent of studies were of diagnostic quality. The average scan time was 22 ± 6 min (contrast) and 12 ± 4 min (non-contrast), a potential cost/throughput reduction of between 30 and 60%. Cardiovascular magnetic resonance findings impacted management in 62%, including a new diagnosis in 22% and MIO detected in 30% of non-contrast scans. Nine centres continued using rapid CMR 2 years later (typically 1–2 days per week, 30 min slots).

Conclusions
Rapid CMR of diagnostic quality can be delivered using available technology in LMICs. When embedded in care and a training programme, costs are lower, care is improved, and services can be sustained over time.
Remote-delivered cardiac rehabilitation during COVID-19: a prospective cohort comparison of health-related quality of life outcomes and patient experiences
Authors: Candelaria Dion , Kirkness Ann , Farrell Maura , Roach Kellie , Gooley Louise , Fletcher Ashlee , Ashcroft Sarah , Glinatsis Helen , Bruntsch Christine , Roberts Jayne , Randall Sue , Gullick Janice , Ladak Laila Akbar , Soady Keith , Gallagher Robyn 
Published: January 2022

AbstractAimsEnforced suspension and reduction of in-person cardiac rehabilitation (CR) services during the coronavirus disease-19 (COVID-19) pandemic restrictions required rapid implementation of remote delivery methods, thus enabling a cohort comparison of in-person vs. remote-delivered CR participants. This study aimed to examine the health-related quality of life (HRQL) outcomes and patient experiences comparing these delivery modes.Methods and resultsParticipants across four metropolitan CR sites receiving in-person (December 2019 to March 2020) or remote-delivered (April to October 2020) programmes were assessed for HRQL (Short Form-12) at CR entry and completion. A General Linear Model was used to adjust for baseline group differences and qualitative interviews to explore patient experiences. Participants (n = 194) had a mean age of 65.94 (SD 10.45) years, 80.9% males. Diagnoses included elective percutaneous coronary intervention (40.2%), myocardial infarction (33.5%), and coronary artery bypass grafting (26.3%). Remote-delivered CR wait times were shorter than in-person [median 14 (interquartile range, IQR 10–21) vs. 25 (IQR 16–38) days, P &lt; 0.001], but participation by ethnic minorities was lower (13.6% vs. 35.2%, P &lt; 0.001). Remote-delivered CR participants had equivalent benefits to in-person in all HRQL domains but more improvements than in-person in Mental Health, both domain [mean difference (MD) 3.56, 95% confidence interval (CI) 1.28, 5.82] and composite (MD 2.37, 95% CI 0.15, 4.58). From qualitative interviews (n = 16), patients valued in-person CR for direct exercise supervision and group interactions, and remote-delivered for convenience and flexibility (negotiable contact times).ConclusionRemote-delivered CR implemented during COVID-19 had equivalent, sometimes better, HRQL outcomes than in-person, and shorter wait times. Participation by minority groups in remote-delivered modes are lower. Further research is needed to evaluate other patient outcomes.
Comparison of various late gadolinium enhancement magnetic resonance imaging methods with high-definition voltage and activation mapping for detection of atrial cardiomyopathy
Authors: Eichenlaub Martin , Mueller-Edenborn Bjoern , Minners Jan , Figueras i Ventura Rosa M , Forcada Barbara Rubio , Colomer Anna Vallès , Hein Manuel , Ruile Philipp , Lehrmann Heiko , Schoechlin Simon , Allgeier Juergen , Bohnen Marius , Trenk Dietmar , Neumann Franz Josef , Arentz Thomas , Jadidi Amir 
Published: January 2022

Abstract

Aims
Atrial cardiomyopathy (ACM) is associated with increased arrhythmia recurrence rates after pulmonary vein isolation (PVI). We compare the most common left atrial (LA) late gadolinium enhancement magnetic resonance imaging (LGE-MRI)-methods [Utah-method and image intensity ratio (IIR)-methods] and endocardial voltage mapping for ACM-detection and outcome prediction after PVI for atrial fibrillation (AF).

Methods and results
In this prospective observational study, 37 ablation-naive patients (66 ± 9 years, 84% male) with persistent AF underwent LA-LGE-MRI and high-definition voltage and activation mapping (2129 ± 484 sites) in sinus rhythm prior to PVI. The MRI-post-processing-analyses were performed by two independent expert laboratories. Arrhythmia recurrence was recorded within 12 months following PVI. The global ACM-extent was highly variable: median LA low-voltage substrate (LA-LVS) was 12.9% at &lt;1.0 mV and 2.7% at &lt;0.5 mV; median LA-LGE-extent using the Utah-method was 18.3% and 0.03–93.1% using the IIR-methods. The LA activation time was significantly correlated with LA-LVS (r = 0.76 at &lt;0.5 mV and r = 0.82 at &lt;1.0 mV, both P &lt; 0.0001), but not with LA-LGE-extent. The highest regional matching between LA-LVS &lt;0.5 mV and LA-LGE was found for the anterior wall in 57% of patients using the Utah-method and in 59% using IIR 1.20. The corresponding values for the posterior wall were 19% and 38%, respectively. Arrhythmia recurrence occurred in 15(41%) patients. Freedom from arrhythmia was significantly lower in those with LA-LVS ≥2 cm2 at 0.5 mV but not in those with LGE ≥20% (Utah-stages III and IV): 43% vs. 81%, P = 0.009 and 50% vs. 67%, P = 0.338, respectively.

Conclusion
Comparison of the most common LA-LGE-MRI methods and endocardial voltage mapping revealed large discrepancies in global and regional ACM-extent.
Self-Enhanced False Memory Across the Life Span
Authors: Wang Jianqin , Otgaar Henry , Howe Mark L , Dong Qun , Zhou Chu 
Published: January 2022

Abstract

Objectives
The role of self in veridical memory has been extensively studied, but what is the role of self in false memory development across the life span? The current study examined the impact of self-reference on associative false memory in children, younger adults, and older adults, and further investigated possible mechanisms concerning how self-reference might affect false memory in different age groups.

Methods
Combining a self-reference manipulation with the Deese/Roediger–McDermott (DRM) paradigm, children, younger adults, and older adults encoded DRM word lists as paired with their own name, another person’s name, or a red square. Later their true and false recognition memory as well as recollection and familiarity were measured.

Results
A self-enhanced false memory effect was found in all age groups. That is, participants generated more false memories in the self-reference condition relative to the other-reference and neutral conditions. Furthermore, when examining its underlying memory mechanisms, we found that self-reference mainly increased false recollection in younger adults but facilitated familiarity of critical lures in older adults.

Discussion
Although self-reference increases false memory in both younger and older adults, the underlying mechanisms are different in that older adults have more self-relevant false familiarity while younger adults generate more self-relevant phantom recollection. The current study also has implications for eyewitness reports, suggesting that the self-relevance of memory may be one relevant factor to consider when evaluating potential risk factors of false memory.
Application of multiscale magnetotelluric data to mineral exploration: an example from the east Tennant region, Northern Australia
Authors: Jiang Wenping , Duan Jingming , Doublier Michael , Clark Andrew , Schofield Anthony , Brodie Ross C , Goodwin James 
Published: January 2022

SUMMARY
The footprint of a mineral system is potentially detectable at a range of scales and lithospheric depths, reflecting the size and distribution of its components. Magnetotellurics is one of a few techniques that can provide multiscale data sets to image and understand mineral systems. We have used long-period data from the Australian Lithospheric Architecture Magnetotelluric Project (AusLAMP) as a first-order reconnaissance survey to resolve large-scale lithospheric architecture for mapping areas of mineral potential in northern Australia. The 3-D resistivity model reveals a broad conductivity anomaly extending from the Tennant Creek district to the Murphy Province in the lower crust and upper mantle, representing a potential fertile source region for mineral systems. Results from a higher-resolution infill magnetotelluric survey reveal two prominent conductors in an otherwise resistive host whose combined responses result in the lithospheric-scale conductivity anomaly mapped in the AusLAMP model. Integration of the conductivity structure with deep seismic reflection data reveals a favourable crustal architecture linking the lower, fertile source regions with potential depositional sites in the upper crust. The enhanced conductivity likely resulted from the remnant (metallic) material deposited when fluids were present during the ‘ancient’ tectonic events. This observation strongly suggests that the deep-penetrating major faults potentially acted as pathways for transporting metalliferous fluids to the upper crust where they could form mineral deposits. This result and its integration with other geophysical and geochronological data sets suggest high prospectivity for major mineral deposits in the vicinity of these major faults, that is, Gulunguru Fault and Lamb Fault. In addition to these insights, interpretation of high-frequency magnetotelluric data acquired during the infill survey helps to characterize cover and assist with selecting targets for stratigraphic drilling which, in turn, can validate the models and improve our understanding of basement geology, cover sequences and mineral potential. This study demonstrates that integration of geophysical data from multiscale surveys is an effective approach to scale reduction during mineral exploration in covered terranes with limited geological knowledge.
Comparison of transient electromagnetic fields excited by single- and double-line grounded-wire sources on land
Authors: Zhou Nan-nan , Xue Guoqiang , Li Hai , Kangxin Lei , Chen Wen 
Published: January 2022

SUMMARY
The lack of a systematic comparison of field surveys on land makes it challenging to select a suitable grounded-wire transient electromagnetic (TEM) source. Therefore, in this study, we compare land-based TEM methods with single- and double-line grounded-wire sources in the broadside direction. The comparison results indicate that the amplitude of the electric field from the double-line source is one or two orders weaker than that of the single-line source in the same time range. Further, we compare the detectability of horizontal electric fields for resistive or conductive targets by analysing the root mean square misfit and decay curves. According to the decay curve analysis, the double-line source shows better detectability for resistive targets, whereas the single-line source has a larger depth of investigation in the broadside direction. In the presence of a resistive target, sign reversal is more likely in the broadside direction for the double-line source than for the single-line source. In the field survey over Kalatongke Ni-Cu sulphide deposits in Xinjiang, China, both single- and double-line configurations can locate the resistive target; however, the latter configuration outperforms the former in discriminating the different values of the resistive rocks in the broadside direction. The double-line source will be the preferred choice for exploring resistive targets in the broadside direction.
Intruders in the Scottish church: clerical allegiance and English clergymen in Scotland during the Second War of Independence, 1332–57
Authors: McHugh Jenny M 
Published: January 2022

Abstract
Ecclesiastics on both sides of the Anglo-Scottish border have often been forgotten in discussions of allegiance and political identity during the Scottish Wars of Independence. This article explores the careers and loyalties of English clergymen working in Scotland, their relationship to their Scottish counterparts, and their influence on the political landscape of the Anglo-Scottish border. It argues that the lives of these men can offer unique insights into the English administration of Scotland between 1332 and 1357, and challenges claims that the English sought to incorporate the regions of Berwickshire and Roxburghshire into the kingdom of England.
A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis
Authors: Katsoula Georgia , Steinberg Julia , Tuerlings Margo , Coutinho de Almeida Rodrigo , Southam Lorraine , Swift Diane , Meulenbelt Ingrid , Wilkinson J Mark , Zeggini Eleftheria 
Published: January 2022

Abstract
Osteoarthritis is a prevalent joint disease and a major cause of disability worldwide with no curative therapy. Development of disease-modifying therapies requires a better understanding of the molecular mechanisms underpinning disease. A hallmark of osteoarthritis is cartilage degradation. To define molecular events characterizing osteoarthritis at the whole transcriptome level, we performed deep RNA sequencing in paired samples of low- and high-osteoarthritis grade knee cartilage derived from 124 patients undergoing total joint replacement. We detected differential expression between low- and high-osteoarthritis grade articular cartilage for 365 genes and identified a 38-gene signature in osteoarthritis cartilage by replicating our findings in an independent dataset. We also found differential expression for 25 novel long non-coding RNA genes (lncRNAs) and identified potential lncRNA interactions with RNA-binding proteins in osteoarthritis. We assessed alterations in the relative usage of individual gene transcripts and identified differential transcript usage for 82 genes, including ABI3BP, coding for an extracellular matrix protein, AKT1S1, a negative regulator of the mTOR pathway and TPRM4, coding for a transient receptor potential channel. We further assessed genome-wide differential splicing, for the first time in osteoarthritis, and detected differential splicing for 209 genes, which were enriched for extracellular matrix, proteoglycans and integrin surface interactions terms. In the largest study of its kind in osteoarthritis, we find that isoform and splicing changes, in addition to extensive differences in both coding and non-coding sequence expression, are associated with disease and demonstrate a novel layer of genomic complexity to osteoarthritis pathogenesis.
Maximal Hörmander Functional Calculus onLpSpaces and UMD Lattices
Authors: Deleaval Luc , Kriegler Christoph 
Published: January 2022

AbstractLet $A$ be a generator of an analytic semigroup having a Hörmander functional calculus on $X = L^p(\Omega ,Y)$, where $Y$ is a UMD lattice. Using methods from Banach space geometry in connection with functional calculus, we show that for Hörmander spectral multipliers decaying sufficiently fast at $\infty $, there holds a maximal estimate $\| \sup _{t&gt; 0} |m(tA)f|\, \|_{L^p(\Omega ,Y)} \lesssim \|f\|_{L^p(\Omega ,Y)}$. We also show square function estimates $\left \| \left ( \sum _k \sup _{t&gt; 0} |m_k(tA)f_k|^2 \right )^{\frac 12} \right \|_{L^p(\Omega ,Y)} \lesssim \left \| \left ( \sum _k |f_k|^2 \right )^{\frac 12} \right \|_{L^p(\Omega ,Y)}$ for suitable families of spectral multipliers $m_k$, which are even new for the euclidean Laplacian on scalar valued $L^p(\ensuremath {{\mathbb {R}}}^d)$. As corollaries, we obtain maximal estimates for wave propagators and Bochner–Riesz means. Finally, we illustrate the results by giving several examples of operators $A$ that admit a Hörmander functional calculus on some $L^p(\Omega ,Y)$ and discuss examples of lattices $Y$ and non-self-adjoint operators $A$ fitting our context.