bluuebunny/crossref_metadata_2025_split huggingface dataset:
CBX4 contributes to HIV‐1 latency by forming phase‐separated nuclear bodies and SUMOylating EZH2
Authors: Wu Liyang , Pan Ting , Zhou Mo , Chen Tao , Wu Shiyu , Lv Xi , Liu Jun , Yu Fei , Guan Yuanjun , Liu Bingfeng , Zhang Wanying , Deng Xiaohui , Chen Qianyu , Liang Anqi , Lin Yingtong , Wang Lilin , Tang Xiaoping , Cai Weiping , Li Linghua , He Xin , Zhang Hui , Ma Xiancai 
Published: June 2022

AbstractThe retrovirus HIV‐1 integrates into the host genome and establishes a latent viral reservoir that escapes immune surveillance. Molecular mechanisms of HIV‐1 latency have been studied extensively to achieve a cure for the acquired immunodeficiency syndrome (AIDS). Latency‐reversing agents (LRAs) have been developed to reactivate and eliminate the latent reservoir by the immune system. To develop more promising LRAs, it is essential to evaluate new therapeutic targets. Here, we find that CBX4, a component of the Polycomb Repressive Complex 1 (PRC1), contributes to HIV‐1 latency in seven latency models and primary CD4+ T cells. CBX4 forms nuclear bodies with liquid–liquid phase separation (LLPS) properties on the HIV‐1 long terminal repeat (LTR) and recruits EZH2, the catalytic subunit of PRC2. CBX4 SUMOylates EZH2 utilizing its SUMO E3 ligase activity, thereby enhancing the H3K27 methyltransferase activity of EZH2. Our results indicate that CBX4 acts as a bridge between the repressor complexes PRC1 and PRC2 that act synergistically to maintain HIV‐1 latency. Dissolution of phase‐separated CBX4 bodies could be a potential intervention to reactivate latent HIV‐1.
Europski platni nalog - naplata dospjelih novčanih potraživanja od stranih pravnih i fizičkih osoba
Authors: Nižić-Peroš Jadranka 
Published: June 2022

Predmet ovog rada je analiza zakonskog uređenja i sudske prakse u svezi izdavanja europskog platnog naloga te je svrha ovog rada pružiti poticaj pravnim i fizičkim osobama za buduće korištenje ovog instrumenta koji se primjenjuje u Republici Hrvatskoj od dana pristupanja Europskoj Uniji, od srpnja 2013., a koji se koristi u izuzetno malom broju slučajeva. Za izdavanje europskog platnog naloga u Republici Hrvatskoj su nadležni sudovi te se radi o instrumentu kojim se naplaćuje tražbina od stranih pravnih i fizičkih osoba, dužnika, bez potrebe znanja jezika Europske unije. Stoga se upravo primjenom postupka izdavanja platnog naloga omogućuje jednostavna, brza i jeftina sudska naplata tražbine od dužnika sa pretpostavkom da tražbina neće biti osporena od strane dužnika. Europski platni nalog je alternativni postupak u odnosu na postupak koji se provodi na nacionalnoj razini te je najveća prednost ovog postupka njegova praktičnost jer je potrebno podnijeti samo jedan zahtjev na propisanom obrascu dostupnom na jezicima svih zemalja Europske unije, a koji obrazac je svima dostupan na internetskom portalu e-pravosuđe. U radu se analizira izdavanje platnog naloga od strane država članica Europske unije, osim Danske, obzirom da vjerovnici iz Republike Hrvatske mogu tražiti izdavanje europskog platnog naloga protiv svojih dužnika neposredno u svim ostalim državama članicama Europske unije. Polazi se od stajališta da u poslovnom svijetu veliki problem predstavljaju nenaplaćena dospjela potraživanja prema stranim pravnim i fizičkim osobama te da je ulaskom u Europsku uniju vjerovnicima omogućeno da naplate svoja potraživanja prema dužnicima koji žive u nekoj od zemalja Europske unije na brz i jednostavan način, a o čemu prema mišljenju autora, vjerovnici nemaju dovoljna saznanja. Primjena Uredbe (EZ) br. 1896/2006 kojom se regulira postupak izdavanja europskog platnog naloga je od iznimne važnosti upravo iz razloga što se njezinom primjenom osiguravaju jednaki uvjeti naplate nespornih (neosporenih) građanskih i trgovačkih tražbina na području cijele Europske unije osim Danske.
A Criminalization of Civil Servant in Case of Neutrality Violations in a Regional Head Election
Authors: Rusdiana Emmilia , Maharani Rizkiyah Putri 
Published: June 2022

This study aims to validate and analyze the accuracy of sentencing the the defendant as the head of the service in fulfilling the elements of the legal subject as a Civil Servant, as well as legal proof of the defendant's actions which are considered beneficial or detrimental to one of the candidate pairs. Legal research with normative juridical, as well as statutory, case, and conceptual approaches and analyzed prescriptively. The accuracy of sentencing the the defendant in Decision Number 147/Pid.Sus/2018/PN.Sdr regarding legal subjects is based that the Panel of a judge s interprets ASN holding certain positions in government as ASN. The judge's considerations did not refer to the Civil Servant Law and the the defendant was a High Pratama Official, belonging to an Echelon 2 position, and this was based on the theory of a criminal responsibility that the actions taken by the the defendant were a burden of personal responsibility not the responsibility of the position. It has nothing to do with the main duties and official functions as Head of the Social, Civil and Population Registration Service, and not as a legitimate job order task. Legal proof of the the phrase "favorable" or "detrimental" to one of the Candidate pairs is inappropriate, because it is not based on the benefit or harm is a formal offense so it does not need to be proven because there is a potential loss and at the same time the theory of economics analysis of law on the principle of optimization, proving cost-benefit analysis, the principle of balance, and the principle of efficiency.
Exploration of Relational Thinking Skills Using Problem Solving of Geometry Transformation
Authors: Ramadhan Sahrul , Effendi Moh Mahfud , Ummah Siti Khoiruli 
Published: June 2022

The aimed study is analyzing the mathematical ability of students with relational thinking skills in geometry transformation material. This study used a descriptive qualitative approach. Data collection techniques were carried out by giving tests based on contextual problems and interviews. The test result was used to measure the effectiveness and completeness of learning outcomes. Furthermore, the result of the interviews supported the data of test results and identified the problem that was faced during the process of the test. The research showed that the most achieved indicator is the first indicator which can write the important information and create the relation about the description of the problem. Meanwhile, the least indicator that has been achieved was the third and fourth indicator which analyzed the relation by using structures, symbols, and properties to find models and re-check in the form of sketching and operating matrices transformation.Tujuan dari penelitian ini yaitu “mengkaji kemampuan matematis peserta didik dengan relational thinking skill pada materi transformasi geometri”. Penelitian ini menggunakan deskripstif dengan pendekatan kualitatif. Teknik pengumpulan data dilakukan dengan memberikan soal tes berbasis permasalahan kontekstual dan wawancara. Hasil test digunakan untuk mengukur keefektifan dan ketuntasan hasil belajar. Selanjutnya hasil wawancara mendukung data dari hasil tes dan mengidentifikasi masalah yang dihadapi selama proses tes. Hasil penelitian menunjukkan bahwa Indikator yang paling banyak dicapai yaitu indikator pertama yang mana mampu menuliskan informasi penting dan membentuk relasi tentang gambaran sebuah masalah. Sementara itu, indikator yang paling sedikit dicapai adalah indikator ketiga dan keempat yang mana menganalisis relasi dengan menggunakan struktur, simbol, dan sifat untuk mencari model dan mengecek kembali dalam bentuk sketsa dan operasi transformasi matriks.
Demographic and Clinical Differences Between Applied Definitions of Medical Complexity
Authors: Heneghan Julia A. , Goodman Denise M. , Ramgopal Sriram 
Published: June 2022

OBJECTIVES
To identify the degree of concordance and characterize demographic and clinical differences between commonly used definitions of multisystem medical complexity in children hospitalized in children’s hospitals.

METHODS
We conducted a retrospective, cross-sectional cohort study of children &lt;21 years of age hospitalized at 47 US Pediatric Health Information System-participating children’s hospitals between January 2017 to December 2019. We classified patients as having multisystem complexity when using 3 definitions of medical complexity (pediatric complex chronic conditions, pediatric medical complexity algorithm, and pediatric chronic critical illness) and assessed their overlap. We compared demographic, clinical, outcome, cost characteristics, and longitudinal healthcare utilization for each grouping.

RESULTS
Nearly one-fourth (23.5%) of children hospitalized at Pediatric Health Information System-participating institutions were identified as meeting at least 1 definition of multisystem complexity. Children with multisystem complexity ranged from 1.0% to 22.1% of hospitalized children, depending on the definition, with 31.2% to 95.9% requiring an ICU stay during their index admission. Differences were seen in demographic, clinical, and resource utilization patterns across the definitions. Definitions of multisystem complexity demonstrated poor agreement (Fleiss’ κ 0.21), with 3.5% of identified children meeting all 3.

CONCLUSIONS
Three definitions of multisystem complexity identified varied populations of children with complex medical needs, with poor overall agreement. Careful consideration is required when applying definitions of medical complexity in health services research, and their lack of concordance should result in caution in the interpretation of research using differing definitions of medical complexity.
Introduzindo o tema da corrupção nas análises sobre mudanças dos modelos de gestão da saúde
Authors: Andreazzi Maria de Fátima Siliansky de 
Published: June 2022

O trabalho, recorte de uma pesquisa sobre privatização da saúde no município do Rio de Janeiro, aborda a principal questão levantada na literatura nacional e internacional sobre os resultados das reformas gerencialistas da Administração pública no contexto do neoliberalismo, que é a falta de controle sobre as parcerias público-privadas e os contratos de gestão. No caso, as Organizações Sociais de Saúde (OSS) têm frequentemente sido envolvidas em processos de corrupção. Faz-se uma breve revisão sobre a corrupção, abordando suas dimensões quantitativas e as concepções correntes. O marco teórico adotado é o marxismo, em especial, a partir de análises de formações econômico-sociais pós ou semicoloniais, onde tem sido encontrado, na contemporaneidade, níveis significativos de corrupção. O caso do Rio de Janeiro abordou 14 OSS que estabeleceram contratos com a prefeitura entre 2009 e 2015 utilizando fontes públicas oficiais, jornais e processos do Ministério Público. Em somente quatro OSS não se identificaram irregularidades, a partir das fontes citadas. As mais comuns envolveram irregularidades na prestação de contas, sobrepreços e pagamento de propinas a agentes públicos. Aponta ao final, que, a contrarreforma do Estado na saúde, ao contrário do proposto nos anos 1990, parece estar facilitando a corrupção, indo contra os princípios da administração pública que orientaram a Constituição de 1988.
A harmonia possível das coisas
Authors: Santos Pedro Brum 
Published: June 2022

A presente reflexão objetiva apontar componentes textuais para ilustrar modos de funcionamento do discurso na narrativa de José Saramago. Papel do autor, posição do narrador, ordenações temporais, amarrações tropológicas e atualização da modalidade romance histórico, dentre outros aspectos, como se procura demonstrar, colocam-se em ordem de uma diversidade de recursos que concorrem para a pluralidade de sentidos, objeto e efeito de vigor artístico e alcance abrangente.
Sources of Variation in the Carbon Footprint of Hemodialysis Treatment
Authors: Sehgal Ashwini R. , Slutzman Jonathan E. , Huml Anne M. 
Published: June 2022

Significance Statement
Studies have demonstrated that hemodialysis facilities have a high environmental effect because the treatment requires large amounts of energy, water, and supplies. However, data regarding how much greenhouse gas emissions from hemodialysis treatment vary across facilities, treatments, and emission contributors have been lacking. In this study, the authors estimated magnitude and sources of variation in the carbon footprint of hemodialysis treatment. They found that the annual emissions per hemodialysis facility are equivalent to emissions from the annual energy use of 93 homes, and emissions per treatment are equivalent to driving an average automobile for 238 km (149 miles). Carbon footprints across facilities, treatments, and emission contributors also varied substantially. Understanding the magnitude and variation in greenhouse gas emissions may help identify measures to reduce the environmental effect of hemodialysis treatment.

Background
Greenhouse gas emissions from hemodialysis treatment in the United States have not been quantified. In addition, no previous studies have examined how much emissions vary across facilities, treatments, and emission contributors.

Methods
To estimate the magnitude and sources of variation in the carbon footprint of hemodialysis treatment, we estimated life-cycle greenhouse gas emissions in carbon dioxide equivalents (CO2-eq) associated with 209,481 hemodialysis treatments in 2020 at 15 Ohio hemodialysis facilities belonging to the same organization. We considered emissions from electricity, natural gas, water, and supply use; patient and staff travel distance; and biohazard and landfill waste.

Results
Annual emissions per facility averaged 769,374 kg CO2-eq (95% CI, 709,388 to 848,180 kg CO2-eq). The three largest contributors to total emissions were patient and staff transportation (28.3%), electricity (27.4%), and natural gas (15.2%). Emissions per treatment were 58.9 kg CO2-eq, with a three-fold variation across facilities. The contributors with the largest variation in emissions per treatment were transportation, natural gas, and water (coefficients of variation, 62.5%, 42.4%, and 37.7%, respectively). The annual emissions per hemodialysis facility are equivalent to emissions from the annual energy use in 93 homes; emissions per treatment are equivalent to driving an average automobile for 238 km (149 miles).

Conclusions
Similar medical treatments provided in a single geographic region by facilities that are part of the same organization may be expected to have small variations in the determinants of greenhouse gas emissions. However, we found substantial variation in carbon footprints across facilities, treatments, and emission contributors. Understanding the magnitude and variation in greenhouse gas emissions may help identify measures to reduce the environmental effect of hemodialysis treatment.
The indicator-based measurement of the circular economy in the countries of the European Union
Authors: Kozma Dorottya Edina , Molnár Tamás , Molnárné Barna Katalin 
Published: June 2022

The circular economy is an integral part of sustainable development as a new economic model, which is the opposite of the linear economy that is still in force today. In terms of its basics, we can speak of a sustainable economic system in which economic growth is completely decoupled from the use of resources, in order to reduce the use of natural resources and recycle them. In the study, the authors present the possibility of measuring the circular economy and establish a ranking for the 28 Member States of the European Union based on the created composite indicators measuring the circular economy. The values of the created CCEI index were compared with rankings produced by other researchers in similar and different ways. The goodness of the presented methodology is examined by comparing previous similar research results.
The primary objective of the study is to create composite indicators and to analyse their comparability. Further aim is to characterise the leading and the tail-ender countries from which conclusions can be drawn regarding ranking and thus make them comparable. The research objective is achieved by using secondary data based on different Eurostat databases related to a sub-sector of the circular economy for the year 2018. The indicators of the circular economy were grouped according to four areas: production and consumption, waste management secondary raw materials, competitiveness and innovation. These areas are adequately show the topics related to the circular economy.
In terms of its structure, the international literature related to the circular economy is reviewed first, followed by the EU strategy and a set of relevant indicators. In the methodological chapter, the methodology of the analysis, the scale coordinate transformation is explained. The research results are compared with the rankings created by other authors and the authors of this study. In this study, the comparison is made from composite indicators using rank correlation, followed by the conclusions.
The research findings of the study highlighted the fact that composite indicators can be created in relation to the circular economy, however, creating and comparing them is not an easy task. The ranking on which the comparison is based shows a very high degree of similarity with the selected rankings. Overall and typically, the leading States, such as Germany, the United Kingdom, the Netherlands and Italy are almost without exception in the top of the rankings in most cases, while the group of tail-enders is led by Malta and Estonia. Based on the results of the macro-level studies, the authors established a kind of competitiveness ranking.
Gelang Giroskop dengan Parameter Sumbu X dan Y sebagai Alat Pemandu Salat bagi Tunarungu
Authors: Nurhafizah Arti , Fajrin Hanifah Rahmi , Kartika Wisnu 
Published: June 2022

Mayoritas penduduk Indonesia beragama Islam, diantaranya lebih dari 13 ribu orang penyandang disabilitas Tunarungu. Dalam melaksanakan Salat berjamaah, Tunarungu kesulitan mengikuti instruksi gerakan Imam. Tujuan pembuatan inovasi alat gelang giroskop adalah untuk membantu penyandang disabilitas Tunarungu mengikuti instruksi gerakan Imam saat melaksanakan Salat berjamaah. Metode yang digunakan pada gelang giroskop adalah dengan memberikan notifikasi berupa getaran yang berbeda pada setiap perubahan gerakan Imam. Sensor pendeteksi perubahan sudut X dan Y yaitu sensor gyroscope MPU6050. Pengaturan range sudut yaitu pada sumbu X dan sumbu Y untuk mendeteksi setiap perubahan gerakan Salat. Sistem kontrol alat menggunakan arduino nano FT232RL FTDI FT232. Modul komunikasi menggunakan HC-12 SI4463.Gelang yang digunakan Imam akan mengirimkan kode berupa perubahan sudut sumbu X dan sumbu Y ke gelang yang digunakan oleh makmum Tunarungu. Tingkat keberhasilan pada gelang giroskop mencapai 89%. Dengan demikian,gelang giroskop pemandu Salat bagi Tunarungu dapat membantu makmum Tunarungu dalam melaksanakan ibadah Salat berjamaah.
Avaliação da estabilidade de taludes em áreas de expansão urbana do município de Rio Piracicaba - MG, Brasil
Authors: Araújo Daniel Miranda Ramos de , Lima Cleverson Alves de , Assis Lais Emily de , Marques Eduardo Antônio Gomes , Menezes Sady Júnior Martins da Costa de , Carvalho Thayse Gama de 
Published: June 2022

Esse estudo teve como objetivo avaliar as condições de estabilidade de três áreas situadas em uma zona de expansão urbana no município de Rio Piracicaba – MG, quando ao movimento de massa. A região apresenta um histórico de instabilizações desta natureza, em especial de escorregamentos translacionais rasos, com superfície de ruptura planar. Para a realização desta pesquisa recorreu-se à utilização de imagens obtidas por um veículo aéreo não tripulado, que permitiram a modelagem do terreno em ambiente SIG, e de amostras de campo indeformadas extraídas para análise geotécnica em laboratório do solo local. Os taludes selecionados para avaliação apresentaram como critérios preponderantes alta declividade, inicio de assentamentos habitacionais informais e terrenos antropizados. Após o levantamento dos dados de campo e de laboratório, os dados foram implementados em uma ferramenta de simulação computacional para obtenção dos seus respectivos fatores de segurança (FS) à luz da norma NBR 11682/2009, na condição saturada, verificando qual o grau de suscetibilidade as encostas e os moradores daquela localidade estavam expostas e que demandam medidas mitigatórias ou corretivas, por parte das autoridades gestoras, a fim de se garantir a segurança dos seus habitantes.
Short Acting Beta Agonist Use Associated with Increased Mortality and Morbidity in Asthma Patients: A Systematic Review and Meta-Analysis
Authors: Hu Yiyun , Kung Janice , Galatis Dimitri , Banh Hoan Linh 
Published: June 2022

Purpose: Short acting b2 agonists are recommended to be used ≤ 2 canisters per year. It is suggested that overuse of b2 agonists will lead to increased morbidity and mortality. This study aimed to determine if overuse of b2 agonists result in increased morbidity and mortality. Methods: We performed a systematic review and meta-analysis of the literature to determine if overuse of b2 agonists cause increase mortality, ICU admissions, hospitalization, and exacerbation. Results: A total of 11,888 publications were identified and 4260 duplications were removed, resulting in 7268 abstracts that were screened and 7254 irrelevant studies that were excluded. Ultimately, 14 studies were included. The overall pooled estimated odds ratio (OR) for mortality was 0.83 (95% CI: 0.66, 1.05), 0.99 for ICU admission (95% CI: 0.80, 1.21), 1.22 for hospitalization (95% CI: 0.96, 1.31), and 0.99 for exacerbation (95% CI: 0.85, 1.15). Conclusion: There is no statistical difference in mortality, ICU admission rate, hospitalization, or exacerbation with using b2 agonists.
Pueblos indígenas y COVID-19 en el Perú: la crisis sanitaria y las deficiencias estructurales
Authors: Orcotorio Figueroa Rodrigo Walter 
Published: June 2022

La pandemia por el COVID-19 es un evento de grandes y complejas proporciones. El Gobierno peruano ha tratado, innumerables veces, de lidiar con sus consecuencias durante el primer año de la crisis. Sin embargo, debido a las condiciones sociales y económicas de la gran mayoría de la población, estos intentos resultaron ser infructuosos y en casos específicos solo agravaron aún más los efectos de la pandemia. En ese sentido, las comunidades nativas, y en general los pueblos indígenas, sufrieron por las ausencias estructurales en materia de servicios públicos (acceso a agua potable y salud) que el COVID-19 se encargó de revelar. Las respuestas tardías del Gobierno central y las preferencias por la reactivación económica dieron cuenta de una seria contradicción entre las prioridades en la gestión de la crisis en los territorios amazónicos.
En el presente trabajo se abordan, en primer lugar, estas condiciones estructurales en materia de servicios públicos, sobre todo aquellas relacionadas con el acceso a agua potable y salud en las comunidades nativas. En segundo lugar, se analizan las medidas legislativas y administrativas implementadas para la protección de las comunidades nativas y el fortalecimiento de sus capacidades contra el COVID-19. Con todo ello, se indagará en las verdaderas falencias y deficiencias de la propuesta nacional para la reactivación económica y el problema vivido por dichas comunidades en el primer año de la crisis.