bluuebunny/crossref_metadata_2025_split huggingface dataset:
Piezoelectric property of PZT nanofibers characterized by resonant piezo-force microscopy
Authors: Zhang Guitao , Chen Xi , Xu Weihe , Yao Wei-Dong , Shi Yong 
Published: March 2022

Nano-piezoelectric materials have drawn tremendous research interest. However, characterization of their piezoelectric properties, especially measuring the piezoelectric strain coefficients, remains a challenge. Normally, researchers use an AFM-based method to directly measure nano-materials’ piezoelectric strain coefficients. But, the extremely small piezoelectric deformation, the influence from the parasitic electrostatic force, and the environmental noise make the measurement results questionable. In this paper, a resonant piezo-force microscopy method was used to accurately measure the piezoelectric deformation from 1D piezoelectric nanofibers. During the experiment, the AFM tip was brought into contact with the piezoelectric sample and set to work at close to its first resonant frequency. A lock-in amplifier was used to pick up the sample’s deformation signal at the testing frequency. By using this technique, the piezoelectric strain constant d33 of the Lead Zirconate Titanate (PZT) nanofiber with a diameter of 76 nm was measured. The result showed that d33 of this PZT nanofiber was around 387 pm/V. Meanwhile, by tracking the piezoelectric deformation phase image, domain structures inside PZT nanofibers were identified.
Rapid-turn inflation in supergravity is rare and tachyonic
Authors: Aragam Vikas , Chiovoloni Roberta , Paban Sonia , Rosati Robert , Zavala Ivonne 
Published: March 2022

Abstract
Strongly non-geodesic, or rapidly turning trajectories in multifield inflation have attracted much interest recently from both theoretical and phenomenological perspectives. Most models with large turning rates in the literature are formulated as effective field theories. In this paper we investigate rapid-turn inflation in supergravity as a first step towards understanding them in string theory. We find that large turning rates can be generated in a wide class of models, at the cost of high field space curvature. In these models, while the inflationary trajectories are stable, one Hessian eigenvalue is always tachyonic and large, in Hubble units. Thus, these models satisfy the de Sitter swampland conjecture along the inflationary trajectory. However, the high curvatures underscore the difficulty of obtaining rapid-turn inflation in realistic string-theoretical models.
In passing, we revisit the η-problem in multifield slow-roll inflation and show that it does not arise, inasmuch as the inflatons, ϕi
, can all be heavier (in absolute value) that the Hubble scale: |mi
|/H>1, ∀i.
The Near-infrared Imager and Slitless Spectrograph for the James Webb Space Telescope. II. Wide Field Slitless Spectroscopy
Authors: Willott Chris J. , Doyon René , Albert Loic , Brammer Gabriel B. , Dixon William V. , Muzic Koraljka , Ravindranath Swara , Scholz Aleks , Abraham Roberto , Artigau Étienne , Bradač Maruša , Goudfrooij Paul , Hutchings John B. , Iyer Kartheik G. , Jayawardhana Ray , LaMassa Stephanie , Martis Nicholas , Meyer Michael R. , Morishita Takahiro , Mowla Lamiya , Muzzin Adam , Noirot Gaël , Pacifici Camilla , Rowlands Neil , Sarrouh Ghassan , Sawicki Marcin , Taylor Joanna M. , Volk Kevin , Zabl Johannes 
Published: March 2022

Abstract
We present the wide field slitless spectroscopy mode of the NIRISS instrument on the James Webb Space Telescope. This mode employs two orthogonal low-resolution (resolving power ≈150) grisms in combination with a set of six blocking filters in the wavelength range 0.8–2.3 μm to provide a spectrum of almost every source across the field-of-view. When combined with the low background, high sensitivity and high spatial resolution afforded by the telescope, this mode will enable unprecedented studies of the structure and evolution of distant galaxies. We describe the performance of the as-built hardware relevant to this mode and expected imaging and spectroscopic sensitivity. We discuss operational and calibration procedures to obtain the highest quality data. As examples of the observing mode usage, we present details of two planned Guaranteed Time Observations programs: The Canadian NIRISS Unbiased Cluster Survey and The NIRISS Survey for Young Brown Dwarfs and Rogue Planets.
The role of pickup truck electrification in the decarbonization of light-duty vehicles
Authors: Woody Maxwell , Vaishnav Parth , Keoleian Gregory A , De Kleine Robert , Kim Hyung Chul , Anderson James E , Wallington Timothy J 
Published: March 2022

AbstractElectrification can reduce the greenhouse gas (GHG) emissions of light-duty vehicles. Previous studies have focused on comparing battery electric vehicle (BEV) sedans to their conventional internal combustion engine vehicle (ICEV) or hybrid electric vehicle (HEV) counterparts. We extend the analysis to different vehicle classes by conducting a cradle-to-grave life cycle GHG assessment of model year 2020 ICEV, HEV, and BEV sedans, sports utility vehicles (SUVs), and pickup trucks in the United States. We show that the proportional emissions benefit of electrification is approximately independent of vehicle class. For sedans, SUVs, and pickup trucks we find HEVs and BEVs have approximately 28% and 64% lower cradle-to-grave life cycle emissions, respectively, than ICEVs in our base case model. This results in a lifetime BEV over ICEV GHG emissions benefit of approximately 45 tonnes CO2e for sedans, 56 tonnes CO2e for SUVs, and 74 tonnes CO2e for pickup trucks. The benefits of electrification remain significant with increased battery size, reduced BEV lifetime, and across a variety of drive cycles and decarbonization scenarios. However, there is substantial variation in emissions based on where and when a vehicle is charged and operated, due to the impact of ambient temperature on fuel economy and the spatiotemporal variability in grid carbon intensity across the United States. Regionally, BEV pickup GHG emissions are 13%–118% of their ICEV counterparts and 14%–134% of their HEV counterparts across U.S. counties. BEVs have lower GHG emissions than HEVs in 95%–96% of counties and lower GHG emissions than ICEVs in 98%–99% of counties. As consumers migrate from ICEVs and HEVs to BEVs, accounting for these spatiotemporal factors and the wide range of available vehicle classes is an important consideration for electric vehicle deployment, operation, policymaking, and planning.
Comparison of FDA Table of Pharmacogenetic Associations and Clinical Pharmacogenetics Implementation Consortium guidelines
Authors: Pritchard Daryl , Patel Jai N , Stephens Lindsay E , McLeod Howard L 
Published: March 2022

Abstract

Purpose
Healthcare professionals need a clear understanding of information about gene-drug interactions in order to make optimal use of pharmacogenetic (PGx) testing. In this report, we compare PGx information in the US Food and Drug Administration (FDA) Table of Pharmacogenetic Associations with information presented in Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines.

Summary
Information from CPIC guidelines and the FDA Table of Pharmacogenetic Associations do not have a high level of concordance. Many drugs mentioned in CPIC guidelines are not listed in the FDA table and vice versa, and the same gene-drug association and dosing recommendation was reported for only 5 of the 126 drugs included in either source. Furthermore, classification of drugs in specific sections of the FDA table does not correlate well with CPIC-assigned or provisionally assigned clinical actionability levels. The Pharmacogenomics Knowledge Base (PharmGKB) clinical annotation levels are generally high for drugs mentioned in CPIC guidelines. PharmGKB clinical annotation levels are often unassigned or are lower level for drugs listed on the FDA table but not in CPIC guidelines. These differences may be due in part to FDA having access to PGx information that is unavailable in published literature and/or because PGx classifications are based on criteria other than clinical actionability.

Conclusion
There are important differences between the PGx information presented in the FDA Table of Pharmacogenetic Associations and in CPIC guidelines. FDA and CPIC have different perspectives when evaluating PGx associations and use different approaches and information resources when considering clinical validity related to specific medicines. Understanding how information sources developed by each group differ and can be used together to form a holistic view of PGx may be helpful in increasing adoption of these information sources in practice.
A Meta-Regression of Trial Features Predicting the Effects of Alcohol Use Disorder Pharmacotherapies on Drinking Outcomes in Randomized Clinical Trials: A Secondary Data Analysis
Authors: Grodin Erica N , Donato Suzanna , Du Han , Green ReJoyce , Bujarski Spencer , Ray Lara A 
Published: February 2022

Abstract

Aims
To test whether two critical design features, inclusion criteria of required pre-trial abstinence and pre-trial alcohol use disorder (AUD) diagnosis, predict the likelihood of detecting treatment effects in AUD pharmacotherapy trials.

Methods
This secondary data analysis used data collected from a literature review to identify randomized controlled pharmacotherapy trials for AUD. Treatment outcomes were selected into abstinence and no heavy drinking. Target effect sizes were calculated for each outcome and a meta-regression was conducted to test the effects of required pre-trial abstinence, required pre-trial AUD diagnosis, and their interaction on effect sizes. A sub-analysis was conducted on trials, which included FDA-approved medications for AUD.

Results
In total, 118 studies testing 19 medications representing 21,032 treated participants were included in the meta-regression analysis. There was no significant effect of either predictor on abstinence or no heavy drinking outcomes in the full analysis or in the sub-study of FDA-approved medications.

Conclusion
By examining these design features in a quantitative, rather than qualitative, fashion the present study advances the literature and shows that requiring AUD diagnosis or requiring pre-trial abstinence do not impact the likelihood of a significant medication effect in the trial.
Complex patterns of ploidy in a holocentric plant clade (Schoenus, Cyperaceae) in the Cape biodiversity hotspot
Authors: Elliott Tammy L , Muasya A Muthama , Bureš Petr 
Published: February 2022

AbstractBackground and AimsIt is unclear how widespread polyploidy is throughout the largest holocentric plant family – the Cyperaceae. Because of the prevalence of chromosomal fusions and fissions, which affect chromosome number but not genome size, it can be impossible to distinguish if individual plants are polyploids in holocentric lineages based on chromosome count data alone. Furthermore, it is unclear how differences in genome size and ploidy levels relate to environmental correlates within holocentric lineages, such as the Cyperaceae.MethodsWe focus our analyses on tribe Schoeneae, and more specifically the southern African clade of Schoenus. We examine broad-scale patterns of genome size evolution in tribe Schoeneae and focus more intensely on determining the prevalence of polyploidy across the southern African Schoenus by inferring ploidy level with the program ChromEvol, as well as interpreting chromosome number and genome size data. We further investigate whether there are relationships between genome size/ploidy level and environmental variables across the nutrient-poor and summer-arid Cape biodiversity hotspot.Key ResultsOur results show a large increase in genome size, but not chromosome number, within Schoenus compared to other species in tribe Schoeneae. Across Schoenus, there is a positive relationship between chromosome number and genome size, and our results suggest that polyploidy is a relatively common process throughout the southern African Schoenus. At the regional scale of the Cape, we show that polyploids are more often associated with drier locations that have more variation in precipitation between dry and wet months, but these results are sensitive to the classification of ploidy level.ConclusionsPolyploidy is relatively common in the southern African Schoenus, where a positive relationship is observed between chromosome number and genome size. Thus, there may be a high incidence of polyploidy in holocentric plants, whose cell division properties differ from monocentrics.
Maize brace root mechanics vary by whorl, genotype and reproductive stage
Authors: Hostetler Ashley N , Erndwein Lindsay , Ganji Elahe , Reneau Jonathan W , Killian Megan L , Sparks Erin E 
Published: March 2022

Abstract

Background and Aims
Root lodging is responsible for significant crop losses worldwide. During root lodging, roots fail by breaking, buckling or pulling out of the ground. In maize, above-ground roots, called brace roots, have been shown to reduce susceptibility to root lodging. However, the underlying structural–functional properties of brace roots that prevent root lodging are poorly defined. In this study, we quantified structural mechanical properties, geometry and bending moduli for brace roots from different whorls, genotypes and reproductive stages.

Methods
Using 3-point bend tests, we show that brace root mechanics are variable by whorl, genotype and reproductive stage.

Key Results
Generally, we find that within each genotype and reproductive stage, the brace roots from the first whorl (closest to the ground) had higher structural mechanical properties and a lower bending modulus than brace roots from the second whorl. There was additional variation between genotypes and reproductive stages. Specifically, genotypes with higher structural mechanical properties also had a higher bending modulus, and senesced brace roots had lower structural mechanical properties than hydrated brace roots.

Conclusions
Collectively these results highlight the importance of considering whorl-of-origin, genotype and reproductive stage for the quantification of brace root mechanics, which is important for mitigating crop loss due to root mechanical failure.
Systematic optimization of host-directed therapeutic targets and preclinical validation of repositioned antiviral drugs
Authors: Xie Dafei , He Song , Han Lu , Wu Lianlian , Huang Hai , Tao Huan , Zhou Pingkun , Shi Xunlong , Bai Hui , Bo Xiaochen 
Published: February 2022

Abstract
Inhibition of host protein functions using established drugs produces a promising antiviral effect with excellent safety profiles, decreased incidence of resistant variants and favorable balance of costs and risks. Genomic methods have produced a large number of robust host factors, providing candidates for identification of antiviral drug targets. However, there is a lack of global perspectives and systematic prioritization of known virus-targeted host proteins (VTHPs) and drug targets. There is also a need for host-directed repositioned antivirals. Here, we integrated 6140 VTHPs and grouped viral infection modes from a new perspective of enriched pathways of VTHPs. Clarifying the superiority of nonessential membrane and hub VTHPs as potential ideal targets for repositioned antivirals, we proposed 543 candidate VTHPs. We then presented a large-scale drug–virus network (DVN) based on matching these VTHPs and drug targets. We predicted possible indications for 703 approved drugs against 35 viruses and explored their potential as broad-spectrum antivirals. In vitro and in vivo tests validated the efficacy of bosutinib, maraviroc and dextromethorphan against human herpesvirus 1 (HHV-1), hepatitis B virus (HBV) and influenza A virus (IAV). Their drug synergy with clinically used antivirals was evaluated and confirmed. The results proved that low-dose dextromethorphan is better than high-dose in both single and combined treatments. This study provides a comprehensive landscape and optimization strategy for druggable VTHPs, constructing an innovative and potent pipeline to discover novel antiviral host proteins and repositioned drugs, which may facilitate their delivery to clinical application in translational medicine to combat fatal and spreading viral infections.
Sex-specific effects of bisphenol A on the signaling pathway of ESRRG in the human placenta
Authors: Zou Zhiyong , Harris Lynda K , Forbes Karen , Heazell Alexander E P 
Published: February 2022

Abstract
Bisphenol A (BPA) exposure during pregnancy is associated with low fetal weight, particularly in male fetuses. The expression of estrogen-related receptor gamma (ESRRG), a receptor for BPA in the human placenta, is reduced in fetal growth restriction. This study sought to explore whether ESRRG signaling mediates BPA-induced placental dysfunction and determine whether changes in the ESRRG signaling pathway are sex-specific. Placental villous explants from 18 normal term pregnancies were cultured with a range of BPA concentrations (1 nM–1 μM). Baseline BPA concentrations in the placental tissue used for explant culture ranged from 0.04 to 5.1 nM (average 2.3 ±1.9 nM; n = 6). Expression of ESRRG signaling pathway constituents and cell turnover were quantified. BPA (1 μM) increased ESRRG mRNA expression after 24 h in both sexes. ESRRG mRNA and protein expression was increased in female placentas treated with 1 μM BPA for 24 h but was decreased in male placentas treated with 1 nM or 1 μM for 48 h. Levels of 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) and placenta specific-1 (PLAC1), genes downstream of ESRRG, were also affected. HSD17B1 mRNA expression was increased in female placentas by 1 μM BPA; however, 1 nM BPA reduced HSD17B1 and PLAC1 expression in male placentas at 48 h. BPA treatment did not affect rates of proliferation, apoptosis, or syncytiotrophoblast differentiation in cultured villous explants. This study has demonstrated that BPA affects the ESRRG signaling pathway in a sex-specific manner in human placentas and a possible biological mechanism to explain the differential effects of BPA exposure on male and female fetuses observed in epidemiological studies.
TNFα antagonist in combination with PD-1 blocker to prevent or retard malignant transformation of B[a]P-induced chronic lung inflammation
Authors: Zhao Ai , Li Fanfan , Wei Cheng , Zhou Zhujun , Luo Xianqiang , Wu Haiming , Ning Chunhong , Liu Wanyu , Li Dong , Lin Danni , Liu Shuwen , Zhang Guangji , Gao Jimin 
Published: March 2022

Abstract
Benzo[a]pyrene (B[a]P) is a typical complete carcinogen in tobacco, but its mechanism of inducing the development of chronic pneumonia and consequent lung cancer is unclear. Here we elucidated the role of myeloid-derived suppressor cells (MDSCs) in developing B[a]P-induced chronic lung inflammation and efficacy of immunotherapy in preventing subsequent malignant transformation. Our study showed that as B[a]P could induce the accumulation of MDSCs in lung tissues and enhance the immunosuppressive effect regulated by cytokines and metabolites, thereby promoting the formation of immunosuppressive microenvironment, where effector T cells were exhausted, NK cells were dysfunctional, regulatory T (Treg) cells were expanded, polarized alveolar macrophages were transformed from M1 to M2. Subsequently, we performed the immunotherapy to block TNFɑ only or both TNFɑ and PD-1 at the early- or middle-stage of B[a]P-induced chronic lung inflammation to ameliorate the immunosuppressive microenvironment. We found that TNFɑ antagonist alone or with PD-1 blocker was shown to exert therapeutic effects on malignant transformation at the early stage of B[a]P-induced chronic lung inflammation. Taken together, our findings demonstrated that B[a]P-induced chronic lung inflammation resulted in the accumulation of MDSCs in lung tissues and exercise their immunosuppressive functions, thereby developing an immunosuppressive microenvironment, thus TNFɑ antagonist alone or with PD-1 blocker could prevent or retard the malignant transformation of B[a]P-induced chronic lung inflammation.
Prediction and action in cortical pain processing
Authors: Koppel Lina , Novembre Giovanni , Kämpe Robin , Savallampi Mattias , Morrison India 
Published: March 2022

AbstractPredicting that a stimulus is painful facilitates action to avoid harm. But how distinct are the neural processes underlying the prediction of upcoming painful events vis-à-vis those taking action to avoid them? Here, we investigated brain activity as a function of current and predicted painful or nonpainful thermal stimulation, as well as the ability of voluntary action to affect the duration of upcoming stimulation. Participants performed a task which involved the administration of a painful or nonpainful stimulus (S1), which predicted an immediately subsequent very painful or nonpainful stimulus (S2). Pressing a response button within a specified time window during S1 either reduced or did not reduce the duration of the upcoming stimulation. Predicted pain increased activation in several regions, including anterior cingulate cortex (ACC), midcingulate cortex (MCC), and insula; however, activation in ACC and MCC depended on whether a meaningful action was performed, with MCC activation showing a direct relationship with motor output. Insula’s responses for predicted pain were also modulated by potential action consequences, albeit without a direct relationship with motor output. These findings suggest that cortical pain processing is not specifically tied to the sensory stimulus, but instead, depends on the consequences of that stimulus for sensorimotor control of behavior.
Prematurity, Delivery Method, and Infant Feeding Type Are Not Associated with Paediatric-onset Inflammatory Bowel Disease Risk: A Scottish Retrospective Birth Cohort Study
Authors: Burgess Christopher J , Schnier Christian , Wood Rachael , Henderson Paul , Wilson David C 
Published: March 2022

AbstractBackground and AimsThe incidence of paediatric-onset inflammatory bowel disease [PIBD] continues to rise globally. We aimed to determine whether mode of delivery, gestational age at birth, or type of infant feeding contribute to the development of PIBD in a nationwide cohort of Scottish children.MethodsAll children born in Scotland between 1981 and 2017 were identified using linked health administrative data to determine mode of delivery, gestational age at birth, and type of infant feeding. PIBD cases were defined as onset of Crohn’s disease [CD], ulcerative colitis [UC], or IBD-unclassified [IBDU] before age 16 years. Validation was performed within an entire Scottish health board [16% of total population] via individual case-note verification. Hazard ratios [HR] were calculated for each exposure using Cox proportional hazards models.ResultsA study population of 2 013 851 children was identified including 1721 PIBD cases. Validation of 261 PIBD patients coded as CD and/or UC identified 242 [93%] as true positive. Children delivered vaginally did not have an altered risk of developing PIBD compared with those delivered by caesarean section, adjusted HR 0.95 [95% CI 0.84-1.08] [p = 0.46]. Compared with children born at term [≥37 weeks], children born prematurely did not have an altered risk of developing PIBD, i.e., at 24-31 weeks of gestation, HR 0.99 [95% CI 0.57-1.71] [p = 0.97] and at 32-36 weeks of gestation, HR 0.96 [95% CI 0.76-1.20] [p = 0.71]. Compared with children exclusively breastfed at age 6 weeks, children exclusively formula fed did not have an altered risk of developing PIBD: adjusted HR 0.97 [95% CI 0.81-1.15] [p = 0.69].ConclusionsThis population-based study demonstrates no association between mode of delivery, gestational age, or exclusive formula feeding at 6 weeks, and the development of PIBD.