bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of a quality improvement strategy with implementation of a specific visual tool to promote ICU early mobilization
Authors: de Souza Patricia Nery , Kroth Jessica Borges , dos Santos Ligero Amanda , Mendes Juliana Mesti , Maida Ana Lígia Vasconcelos , Pastore Laerte , Yamaguti Wellington Pereira 
Published: October 2022

AbstractEarly progressive mobilization is a safe strategy in the intensive care unit (ICU), however, it is still considered challenging by the inherent barriers and poor adherence to early mobilization protocol. The aim of this study was to evaluate the effectiveness of a quality improvement (QI) multifaceted strategy with implementation of a specific visual tool, the “mobility clock”, in reducing non-compliance with the institutional early mobilization (EM) protocol in adult ICUs. A single-center QI with a retrospective before-after comparison study was conducted using data from medical records and hospital electronic databases. Patients from different periods presented similar baseline characteristics. After the QI strategy, a decline in “non-compliance” with the protocol was observed compared to the previous period (10.11% vs. 26.97%, p < 0.004). The proportion of patients walking was significantly higher (49.44% vs. 29.21%, p < 0.006) and the ICU readmission rate was lower in the “after” period (2.25% vs. 11.24%; p = 0.017). The multifaceted strategy specifically designed considering institutional barriers was effective to increase out of bed mobilization, to reduce the “non-compliance” rate with the protocol and to achieve a higher level of mobility in adult ICUs of a tertiary hospital.
Cloning and in silico characterization of an abiotic stress-inducible U-box domain-containing protein gene GsPUB8 from Glycine soja
Authors: Mallano Ali Inayat , Nisa Zaib-un , Khaliq Binish , Ali Naila , Ali Qurban , Chao Chen , Yanming Zhu 
Published: October 2022

AbstractThe ubiquitination pathway is involved in the posttranslational modification of cellular proteins. However, the role of E3 ubiquitin ligase family proteins under abiotic stress conditions remains unclear, particularly in soybean. The core objective of the current study was to isolate and functionally characterize the GsPUB8 protein gene from wild soybean (Glycine soja) by using a homologous cloning method to investigate its abiotic stress responses. The GsPUB8 is a 40,562 Da molecular weight protein with 373 amino acid residues. The sequence alignment revealed the presence of U-box domain while the phylogenetic analysis showed an abundance of PUB8 proteins in both monocot and dicot plants. Analysis of gene structure predicted the absence of introns along with the presence of one exon. Furthermore, the activity of the GsPUB8 protein was anticipated in the plasma membrane and its expression was persuaded with NaCl, ABA, PEG6000, and NaHCO3 treatments with considerably higher manifestation in roots than leaves although, expressed in both vegetative and reproductive parts of G. soja. GsPUB8 protein showed 54% and 32% sequence identity to U-box domain containing 8 and 12 proteins from Arabidopsis thaliana and Oryza sativa subsp. japonica, respectively. GsPUB8 exhibited relatively higher expression under saline and drought stress particularly in roots. Whereas, the 3D model of GsPUB8 protein was generated using the SWISS-MODEL. This study can be used to manipulate the GsPUB8 protein or GsPUB8 gene for transformation purposes and its functional characterization under abiotic stress conditions.
Ferromagnetism modulation by ultralow current in a two-dimensional polycrystalline molybdenum disulphide atomic layered structure
Authors: Muneta Iriya , Shirokura Takanori , Hai Pham Nam , Kakushima Kuniyuki , Tsutsui Kazuo , Wakabayashi Hitoshi 
Published: October 2022

AbstractLayered materials, such as graphene and transition metal dichalcogenides, are able to obtain new properties and functions through the modification of their crystal arrangements. In particular, ferromagnetism in polycrystalline MoS2 is of great interest because the corresponding nonmagnetic single crystals exhibit spontaneous spin splitting only through the formation of grain boundaries. However, no one has reported direct evidence of this unique phenomenon thus far. Herein, we demonstrate ferromagnetism modulation by an ultralow current density < 103 A/cm2 in 7.5-nm-thick polycrystalline MoS2, in which magnetoresistance shows three patterns according to the current intensity: wide dip, nondip and narrow dip structures. Since magnetoresistance occurs because of the interaction between the current of 4d electrons in the bulk and localized 4d spins in grain boundaries, this result provides evidence of the current modulation of ferromagnetism induced by grain boundaries. Our findings pave the way for the investigation of a novel method of magnetization switching with low power consumption for magnetic random access memories.
Sporozoite motility as a quantitative readout for anti-CSP antibody inhibition
Authors: de Korne C. M. , van Schuijlenburg R. , Sijtsma J. C. , de Bes H. M. , Baalbergen E. , Azargoshasb S. , van Oosterom M. N. , McCall M. B. B. , van Leeuwen F. W. B. , Roestenberg M. 
Published: October 2022

AbstractAntibodies can prevent malaria by neutralizing the infectious Plasmodium falciparum sporozoites (SPZ) before they establish an infection in the liver. Circumsporozoite protein (CSP), the most abundant surface protein of SPZ is the leading candidate for passive (and subunit) immunization approaches against malaria. Comprehensive assessment of the parasite-inhibitory capacity of anti-CSP monoclonal antibodies (mAbs) is an important step in advancing CSP-based immunization strategies. In this study, we employed a quantitative imaging-based motility assay to quantify the effect of anti-CSP mAbs on SPZ motility, both in vitro and in human skin.Our assay provided a quantitative measure of mAb parasite-inhibitory capacity through measurement of the half-maximal motility inhibitory concentration (IC50M) value for anti-CSP mAbs (IC50M 2A10: 24 nM, IC50M 3SP2: 71 nM). We found a sevenfold discrepancy between the IC50M and the binding saturation concentration measured by ELISA, possibly related to the observed shedding of CSP-mAb complexes during SPZ movement. In a subset of SPZ (5%), in vitro motility was unaffected by the presence of 2A10 while 3SP2 was able to completely block movement. In our ex vivo skin explant model, SPZ proved less susceptible to anti-CSP mAbs compared to SPZ in an in vitro environment. By quantitatively assessing motility, we created a valuable tool that can be used for comprehensive assessment of anti-CSP mAb potency. Insight that will help deepen our understanding of anti-CSP mAb potency and guide selection of the most promising anti-CSP mAbs for downstream clinical development.
Non-redox reactivity of V(ii) and Fe(ii) formamidinates towards CO2 resulting in the formation of novel M(ii) carbamates
Authors: Korona Krzesimir , Kornowicz Arkadiusz , Justyniak Iwona , Terlecki Michał , Błachowski Artur , Lewiński Janusz 
Published: October 2022

Multiple CO2 insertions into the M–N bonds of V(ii) and Fe(ii) bis(formamidinates) led to the isolation of three novel carbamates. The CO2 insertion effectivity depended on the solvent used and the metal centre's coordination sphere geometry.
Dizziness, Falls, and Hearing Loss in Adults Living With Sickle Cell Disease
Authors: Nelson M. Dawn , Bennett Danielle M. , Lehman Mark E. , Okonji Angela I. 
Published: October 2022

Objective:
The aim of this study was to assess the prevalence of reported dizziness/imbalance, frequency of falls, and hearing loss in adults with sickle cell disease (SCD) and determine the relationship of these self-reported problems both during and in the absence of an SCD crisis. Also, the impact of educational level and health insurance on seeking treatment services, as well as the relationship of falls to stroke, legal blindness, and other orthopedic problems, was assessed. Interrupted blood flow to shared vestibular and auditory arteries supports the notion of increased likelihood of balance deficits and increased falls in this population.

Design:
A cross-sectional survey study design was used. Adults living with SCD responded to a questionnaire that was distributed online and through traditional mail.

Study Sample:

Adults living with SCD (
N
= 135) participated in the study.

Results:
Responses revealed 70% of participants with SCD experienced dizziness/imbalance and 23% reported hearing loss. Furthermore, 33% of participants reported falling one or more times in the last year. The prevalence of dizziness/imbalance, falling, and hearing loss in the respondents with SCD was much higher than that of the general population of the United States. Additionally, for dizziness and falling, the prevalence was higher not only than the national average but also for persons over 65 years of age. A significant association was demonstrated between dizziness/imbalance and hearing loss as well as dizziness/imbalance and falls for adults living with SCD. In fact, participants with self-reported hearing loss were 5.2 times more likely to also report dizziness/imbalance. They were 4.9 times more likely to fall if they also reported dizziness/imbalance. Numbness of the feet was revealed to significantly impact the likelihood of falling in this disease population and should be further studied. Regarding SCD crisis status, dizziness/imbalance and falls were more likely to occur outside of SCD crisis than during a crisis. Furthermore, pain levels were significantly associated with dizziness/imbalance only when respondents were in crisis and not in the absence of a crisis. In crisis, higher pain levels were reported from respondents who also reported dizziness/imbalance than from those who did not report dizziness. No significant relationship was revealed between hearing loss and falls.

Discussion:
These results provide justification for patient and health care provider education regarding appropriate referrals for vestibular/balance assessments and provision of fall prevention strategies. Future studies on balance and SCD are encouraged.
“Tan and Crunchy Is Where We Live”: An Interpretative Phenomenological Analysis of Caregivers' Perspectives of Pediatric Feeding Disorder in Children With Developmental Disability
Authors: Muldoon Deirdre M. , Murphy Thomas M. , DeBonis David A. 
Published: October 2022

Purpose:
The purpose of this study was to examine caregivers' perceptions of feeding disorders in their young child who also had a co-occurring developmental disability (DD).

Method:
Using interpretative phenomenological analysis, eight caregivers of children with DD and pediatric feeding disorder (PFD) were interviewed. Interviews were recorded, transcribed, and analyzed for the lived experiences of caregivers. Thematic analysis, member checking, and an audit were completed by three researchers.

Results:
Three themes emerged: Parenting Journey, Emotions and Repercussions, and Winging It. Results indicated caregivers struggled to find appropriate professional help, referenced lack of confidence in the professionals designated to help, and were often ambivalent in approach to the PFD. Indications were that parents were frequently retelling past experiences as they presented the narrative of the feeding disorder and, as such, created narratives that became part of their present and the future experiences when feeding their child.

Conclusions:
Implications for speech-language pathologists are considered. Particularly, interventions that go beyond the immediate environmental variables of the feeding or mealtime environment are considered, including the application of this analysis to necessary psychological flexibility for caregivers of children with PFD.
A deep learning approach for focal-plane wavefront sensing using vortex phase diversity
Authors: Quesnel M. , Orban de Xivry G. , Louppe G. , Absil O. 
Published: October 2022

Context.The performance of high-contrast imaging instruments is limited by wavefront errors, in particular by non-common path aberrations (NCPAs). Focal-plane wavefront sensing (FPWFS) is appropriate to handle NCPAs because it measures the aberration where it matters the most, that is to say at the science focal plane. Phase retrieval from focal-plane images results, nonetheless, in a sign ambiguity for even modes of the pupil-plane phase.Aims.The phase diversity methods currently used to solve the sign ambiguity tend to reduce the science duty cycle, that is, the fraction of observing time dedicated to science. In this work, we explore how we can combine the phase diversity provided by a vortex coronagraph with modern deep learning techniques to perform efficient FPWFS without losing observing time.Methods.We applied the state-of-the-art convolutional neural network EfficientNet-B4 to infer phase aberrations from simulated focal-plane images. The two cases of scalar and vector vortex coronagraphs (SVC and VVC) were considered using a single post-coronagraphic point spread function (PSF) or two PSFs obtained by splitting the circular polarization states, respectively.Results.The sign ambiguity has been properly lifted in both cases even at low signal-to-noise ratios (S/Ns). Using either the SVC or the VVC, we have reached a very similar performance compared to using phase diversity with a defocused PSF, except for high levels of aberrations where the SVC slightly underperforms compared to the other approaches. The models finally show great robustness when trained on data with a wide range of wavefront errors and noise levels.Conclusions.The proposed FPWFS technique provides a 100% science duty cycle for instruments using a vortex coronagraph and does not require any additional hardware in the case of the SVC.
Accurate cosmic microwave background covariance matrices: Exact calculation and approximations
Authors: Camphuis E. , Benabed K. , Galli S. , Hivon E. , Lilley M. 
Published: October 2022

Context. A reliable estimation of cosmological parameters from pseudo-power spectrum estimators requires accurate covariance matrices.
Aims. We focus on the analytical calculation of covariance matrices. We consider the case of observations of the cosmic microwave background (CMB) in temperature and polarization on a small footprint such as in the South Pole Telescope third-generation (SPT-3G) experiment, which observes 4% of the sky. Power spectra evaluated on small footprints are expected to have strong correlations between modes, and these need to be accurately modeled.
Methods. We present for the first time an algorithm that allows an efficient (but computationally expensive) exact calculation of analytic covariance matrices. Using it as our reference, we tested the accuracy of existing fast approximations of the covariance matrix. Furthermore, we propose a new approximation that is designed to be more precise. Finally, we derived the covariance matrices for mask-corrected power spectra estimated by the PolSpice code. In particular, in the case of a small sky fraction, we included the effect of the apodization of the large-scale modes.
Results. We find that when the power spectrum is binned in wide bandpowers, current approximations of the covariance matrix are correct up to the 5% level on the SPT-3G small sky footprint. Our new approximation improves the previous approximations and reaches a precision of 1% for the wide bandpowers. It is generally more than four times more accurate than current approaches.
Conclusions. While we considered the specific case of the CMB, our results are applicable to any other cosmological probe that requires the calculation of pseudo-power spectrum covariance matrices.
L’épidémiologie psychiatrique en question
Authors: Falissard Bruno 
Published: October 2022

De nombreuses études scientifiques tentent de mesurer la proportion de personnes souffrant de
troubles mentaux comme la dépression ou l’anxiété généralisée dans la population. Les valeurs
obtenues posent souvent problème : que signifient-elles et quelle est leur pertinence scientifique ?
Comment les obtient-on ? Pour répondre à ces questions, il faut se souvenir que le malade est, par
définition, celui qui sonne à la porte du médecin. La maladie, quant à elle, est une construction,
un outil conceptuel qui aide le médecin à penser et à prendre en charge le malade. S’il existe
des classifications modernes des troubles mentaux, elles ont beaucoup de mal à définir clairement
ce qui caractérise le malade plutôt que la maladie. Une des grandes difficultés en épidémiologie
psychiatrique est d’« opérationnaliser » ce qu’est un trouble mental, c’est-à-dire de faciliter et
d’homogénéiser le diagnostic psychiatrique grâce à des instruments standardisés. Compte tenu de
cette complexité à la fois méthodologique et conceptuelle, la plus grande prudence s’impose aux
acteurs de santé publique quand ils prennent leurs décisions sur la base de mesures des différents
troubles psychiatriques dans la population générale.
EFSUMB Clinical Practice Guidelines for Point-of-Care Ultrasound: Part One (Common Heart and Pulmonary Applications) LONG VERSION
Authors: Jarman Robert David , McDermott Cian , Colclough Anna , Bøtker Morten , Knudsen Lars , Harris Tim , Albaroudi Bilal , Albaroudi Omar , Haddad Mahmoud , Darke Robert , Berry Edward , Breslin Tomas , Fitzpatrick Gareth , Flanagan Leah , Olusanya Olusegun , Craver Dominic , Omar Adhnan , Simpson Thomas , Cherian Nishant , Dore Martin , Prosen Gregor , Kay Sharon , Villén-Villegas Tomás , Gargani Luna , Carley Simon , Woo Michael , Dupriez Florence , Hussain Arif , Via Gabriele , Connolly James Anthony , Peck Marcus , Melniker Larry , Walden Andrew , Attard Biancardi Mark Anthony , Żmijewska-Kaczor Olga , Lalande Elizabeth , Geukens Paul , McLaughlin Russell , Olszynski Paul , Hoffmann Beatrice , Chin Eric , Muhr Christopher , Kim Daniel J. , Mercieca Andre , Shukla Dharmesh , Hayward Simon , Smith Michael , Gaspari Romolo , Smallwood Nick , Pes Philippe , Tavazzi Guido , Corradi Francesco , Lambert Michael , Morris Craig , Trauer Michael , Baker Kylie , Bystrzycki Adam , Goudie Adrian , Liu Rachel , Rudd Lynne , Dietrich Christoph F. , Jenssen Christian , Sidhu Paul S. 
Published: October 2022

AbstractAims To evaluate the evidence and produce a summary and recommendations for the most common heart and lung applications of point-of-care ultrasound (PoCUS).Methods We reviewed 10 clinical domains/questions related to common heart and lung applications of PoCUS. Following review of the evidence, a summary and recommendation were produced, including assignment of levels of evidence (LoE) and grading of the recommendation, assessment, development, and evaluation (GRADE). 38 international experts, the expert review group (ERG), were invited to review the evidence presented for each question. A level of agreement of over 75 % was required to progress to the next section. The ERG then reviewed and indicated their level of agreement regarding the summary and recommendation for each question (using a 5-point Likert scale), which was approved if a level of agreement of greater than 75 % was reached. A level of agreement was defined as a summary of “strongly agree” and “agree” on the Likert scale responses.Findings and Recommendations One question achieved a strong consensus for an assigned LoE of 3 and a weak GRADE recommendation (question 1). The remaining 9 questions achieved broad agreement with one assigned an LoE of 4 and weak GRADE recommendation (question 2), three achieving an LoE of 3 with a weak GRADE recommendation (questions 3–5), three achieved an LoE of 3 with a strong GRADE recommendation (questions 6–8), and the remaining two were assigned an LoE of 2 with a strong GRADE recommendation (questions 9 and 10).Conclusion These consensus-derived recommendations should aid clinical practice and highlight areas of further research for PoCUS in acute settings.
Patterns of Prenatal Care Delivery and Obstetric Outcomes before and during the COVID-19 Pandemic
Authors: Kern-Goldberger Adina R. , Sheils Natalie E. , Ventura Maria Eloisa M. , Paderanga Ana Jane A. , Janer Ciara D. , Donato Patricia Rose B. , Asch David A. , Srinivas Sindhu K. 
Published: October 2022

Objective Health care providers and health systems confronted new challenges to deliver timely, high-quality prenatal care during the coronavirus disease 2019 (COVID-19) pandemic as the pandemic raised concerns that care would be delayed or substantively changed. This study describes trends in prenatal care delivery in 2020 compared with 2018 to 2019 in a large, commercially insured population and investigates changes in obstetric care processes and outcomes.
Study Design This retrospective cohort study uses de-identified administrative claims for commercially insured patients. Patients whose entire pregnancy took place from March 1 to December 31 in years 2018, 2019, and 2020 were included. Trends in prenatal care, including in-person, virtual, and emergency department visits, were evaluated, as were prenatal ultrasounds. The primary outcome was severe maternal morbidity (SMM). Secondary outcomes included preterm birth and stillbirth. To determine whether COVID-19 pandemic-related changes in prenatal care had an impact on maternal outcomes, we compared the outcome rates during the pandemic period in 2020 to equivalent periods in 2018 and 2019.
Results In total, 35,112 patients were included in the study. There was a significant increase in the prevalence of telehealth visits, from 1.1 to 1.2% prior to the pandemic to 17.2% in 2020, as well as a significant decrease in patients who had at least one emergency department visit during 2020. Overall prenatal care and ultrasound utilization were unchanged. The rate of SMM across this period was stable (2.3–2.8%) with a statistically significant decrease in the preterm birth rate in 2020 (7.4%) compared with previous years (8.2–8.6%; p < 0.05) and an unchanged stillbirth rate was observed.
Conclusion At a time when many fields of health care were reshaped during the pandemic, these observations reveal considerable resiliency in both the processes and outcomes of obstetric care.
Key Points
Low risk of local recurrence after a successful en bloc endoscopic submucosal dissection for noninvasive colorectal lesions with positive horizontal resection margins (R-ESD study)
Authors: Haasnoot Krijn J. C. , Baldaque-Silva Francisco , Koch Arjun , Figueiredo Ferreira Mariana , Santos-Antunes João , Dias Emanuel , Omae Masami , van Tilburg Laurelle , Dang Hao , Lemmers Arnaud , Boonstra Jurjen J. , Moons Leon M. G. 
Published: October 2022

Background During endoscopic submucosal dissection (ESD), the normal mucosa is cut under constant optical control. We studied whether a positive horizontal resection margin after a complete en bloc ESD predicts local recurrence.
Methods In this European multicenter cohort study, patients with a complete en bloc colorectal ESD were selected from prospective registries. Cases were defined by a horizontal resection margin that was positive or indeterminate for dysplasia (HM1), whereas controls had a free resection margin (HM0). Low risk lesions with submucosal invasion (T1) and margins free of carcinoma were analyzed separately. The main outcome was local recurrence.
Results From 928 consecutive ESDs (2011–2020), 354 patients (40 % female; mean age 67 years, median follow-up 23.6 months), with 308 noninvasive lesions and 46 T1 lesions, were included. The recurrence rate for noninvasive lesions was 1/212 (0.5 %; 95 %CI 0.02 %–2.6 %) for HM0 vs. 2/96 (2.1 %; 95 %CI 0.57 %–7.3 %) for HM1. The recurrence rate for T1 lesions was 1/38 (2.6 %; 95 %CI 0.14 %–13.5 %) for HM0 vs. 2/8 (25 %; 95 %CI 7.2 %–59.1 %) for HM1.
Conclusion A positive horizontal resection margin after an en bloc ESD for noninvasive lesions is associated with a marginal nonsignificant increase in the local recurrence rate, equal to an ESD with clear horizontal margins. This could not be confirmed for T1 lesions.