bluuebunny/crossref_metadata_2025_split huggingface dataset:
BOrderliNe symptoms and suIcide-related outcomes: proTOcol for a systematic review/meta-analysis and an individual patient data meta-analysis (BONITO study)
Authors: Calati Raffaella , Romano Daniele , Lopez-Castroman Jorge , Turolla Federica , Zimmermann Johannes , Madeddu Fabio , Courtet Philippe , Preti Emanuele 
Published: June 2022

IntroductionPrevalence of suicidal thoughts and behaviours is higher among patients with borderline personality disorder than the general population. However, evidence concerning the role of specific borderline symptoms for predicting suicide-related outcomes is lacking and no systematic review/meta-analysis (SR/MA) investigated this topic. Our aim will be to investigate the relationship between any borderline symptom (except criterion 5) and suicide-related outcomes both through an SR/MA and an individual patient data meta-analysis (IPD-MA).MethodsWe will search PubMed/MEDLINE, Scopus, Web of Science, Embase, PsycINFO, CINAHL and Cochrane Library databases from 1974 until September 2021. Both published and unpublished studies showing the association between any borderline symptom (except criterion 5) and suicide-related outcomes (death wish, suicidal ideation, suicidal plan, non-suicidal self-injury, deliberate self-harm, suicide attempt, suicidal behaviour disorder, suicide) will be included. Two team members will independently perform the selection of the studies and data extraction, with the supervision of two other members in case of discrepancies; and assess each study with study quality assessment tools by National Institutes of Health and Grading of Recommendations Assessment, Development and Evaluation. Each author will be contacted. If possible, we will perform both random-effect meta-analyses on the collected data (odds, risk, rate ratios or correlations) and an IPD-MA on collected databases.Ethics and disseminationThis study does not require an ethical approval. Results will be publicly disseminated, included in research presentations and published in peer-review journals.PROSPERO registration numberCRD42018078696.
Impact of COPD and asthma on in-hospital mortality and management of patients with heart failure in England and Wales: an observational analysis
Authors: Gulea Claudia , Zakeri Rosita , Kallis Constantinos , Quint Jennifer K 
Published: June 2022

ObjectiveTo evaluate the association between having concomitant chronic obstructive pulmonary disease (COPD) or asthma, and in-patient mortality and post-discharge management among patients hospitalised for acute heart failure (HF).SettingData were obtained from patients enrolled in the National Heart Failure Audit.Participants217 329 patients hospitalised for HF in England–Wales between March 2012 and 2018.OutcomesIn-hospital mortality, referrals to cardiology follow-up and prescriptions for HF medications were compared between patients with comorbid COPD (COPD-HF) or asthma (asthma-HF) versus HF-alone using mixed-effects logistic regression.ResultsPatients with COPD-HF were more likely to die during hospitalisation, and those with asthma-HF had a reduced likelihood of death, compared with patients who had HF-alone ((adjusted)ORadj, 95% CI: 1.10, 1.06 to 1.14 and ORadj, 95% CI: 0.84, 0.79 to 0.88). In patients who survived to discharge, referral to HF follow-up services differed between groups: patients with COPD-HF had reduced odds of cardiology follow-up (ORadj, 95% CI 0.79, 0.77 to 0.81), while cardiology referral odds for asthma-HF were similar to HF-alone. Overall, proportions of HF medication prescriptions at discharge were low for both COPD-HF and asthma-HF groups, particularly prescriptions for beta-blockers.ConclusionsIn this nationwide analysis, we showed that COPD and asthma significantly impact the clinical course in patients hospitalised for HF. COPD is associated with higher in-patient mortality and lower cardiology referral odds, while COPD and asthma are both associated with lower use of prognostic HF therapies on discharge. These data highlight therapeutic gaps and a need for better integration of cardiopulmonary services to improve healthcare provision for patients with HF and coexisting respiratory disease.
Exploring the key anthropological drivers of and barriers to zoonotic malaria preventative behaviour in a community exposed to Plasmodium knowlesi infection in Malaysia: protocol for a qualitative study with a participatory research design
Authors: Naserrudin Nurul Athirah , Culleton Richard , Hod Rozita , Saffree Jeffree Mohammad , Ahmed Kamruddin , Hassan Mohd Rohaizat 
Published: June 2022

IntroductionPlasmodium knowlesi malaria is a zoonotic mosquito-borne disease with complex epidemiology. According to the WHO, the prevention and control of vector-borne diseases require community participation to increase coherence between malaria interventions and sustainable public health programmes. We describe a participatory research (PR) design for a study aimed at exploring the key anthropological drivers of and barriers to zoonotic malaria preventive behaviour among communities exposed to P. knowlesi infection in Malaysia. Participatory approaches can facilitate policymakers in designing future zoonotic malaria control programmes by investigating community perspectives and concerns about zoonotic malaria in a local context.Methods and analysisThe PR will be conducted over a period of 12 months, from March 2022 to March 2023, among adults (>18 years old) who are permanent residents in a rural village exposed to P. knowlesi malaria in Sabah, Malaysia. We will select patients who were diagnosed with P. knowlesi infection from January to December 2021 for focus group discussions (FGDs), as they can provide perspectives on the disease from the point of view of those previously diagnosed with infection. In-depth interviews (IDIs) with people of importance in the community, such as village heads, will also be conducted. Both FGDs and IDIs will be conducted from March 2022 until June 2022. Concurrently, a photovoice with adults over 18 years old who reside in the community will be conducted. The target sample sizes for FGDs, IDIs and photovoice are 6–8, 12 and 10–15 participants, respectively. We will use a study framework as a theoretical lens to guide the exploration of the beliefs, social contexts, barriers and drivers surrounding zoonotic malaria preventive behaviour.Ethics and disseminationThis study has been approved by the Medical Research and Ethics Committee Ministry of Health Malaysia (NMRR ID-21-01980-JEH) and the Research and Innovation Secretariat, Faculty of Medicine, Universiti Kebangsaan Malaysia (FF-2021-462). All participants will provide consent prior to participation. The results will be reported in international peer-reviewed journals and presented at conferences and on other platforms.
Effect of subgrade on tensile strains in a geomembrane for tailings storage applications
Authors: Fan Jiying , Rowe R. Kerry 
Published: June 2022

Experiments were conducted to quantify short-term tensile strains induced in a 1.5 mm thick high-density polyethylene geomembrane overlain by tailings. Four subgrades, a poorly graded angular to subangular gravel (GP), a well-graded angular to subangular gravel (GW), a poorly subrounded graded sand (SP), and silty sand (SM), and two nonwoven geotextiles, 450 and 1420 g/m2, were evaluated. All the indentations in the geomembrane (GMB) were due to the subgrade, and with an adequate fraction of sand size particles in the subgrade, the tensile strains could be minimized. At 2000 kPa, the maximum tensile strain was 32% for GP, 16% for GW, 13% for SP, and no discernable indentation was observed for SM prepared at the optimum water content of 11%. For the soft SM subgrade prepared at 20% water content, only one indentation with the tensile strain of 2% was observed. At 2000 kPa, a 450 g/m2 geotextile beneath the GMB reduced the maximum tensile strain from 32% to 23% for GP subgrade, from 16% to 8% for GW subgrade, and from 13% to 6% for SP subgrade; the 1420 g/m2 geotextile reduced the maximum tensile strain to 14% for GP subgrade. Thus, minimal subgrade indentation induced strain and hence the possibility of a very long service life of GMB could be achieved using SM subgrade.
Predicting distribution overlaps betweenDendroctonus adjunctusBlandford 1897 and sixPinusspecies in Mexico under global climate change
Authors: Estrada-Contreras Israel , Ruiz-Montiel Cesar , Ibarra-Zavaleta Sara Patricia , Sánchez-Velásquez Lázaro Rafael , Hoyos-Rivera Guillermo J. , Cristóbal-Salas Alfredo , Bourg Amandine , Pineda-López María Del Rosario 
Published: June 2022

Species that coexist nowadays will not necessarily match their distributions in the future due to different climate suitability. The aim of this study was to identify potential distribution areas where the bark beetle Dendroctonus adjunctus and six of its host tree species overlap under different climate change scenarios. Potential distribution maps were built with species presence data using the MaxLike R library. For each projection, we used WorldClim bioclimatic variables, current and future (2050, 2070) condition climate data, two greenhouse gas concentration scenarios (RCP 4.5, RCP 8.5), and three general circulation models. The results show that the projected current potential distribution area of the bark beetle extends over 216 000 km2. This potential distribution range spans across 28 of the 32 Mexican states, eight of which have not yet reported the insect's presence. Of the 72 overlapping maps that we made, the largest covers more than 118 000 km2for Pinus duranguensis, while all future projections show a reduction in spatial coincidence. Given future climatic scenarios, D. adjunctus will probably reach higher altitudinal sites. The information contained in this study can be used to identify areas to prioritize monitoring, management, plant sanitation treatment, and reforestation strategies in Mexican pine forests.
Formando médicos, rol de las emociones. ¿Cómo incorporamos las emociones para un aprendizaje significativo?
Authors: Prieto Florencia , Campos Mónica , Kunakov Natasha 
Published: June 2022

Este artículo destaca el papel que juegan las emociones en la construcción del aprendizaje. Da cuenta de la importancia de las emociones en la interacción cotidiana en el aula, como así mismo durante todo el proceso de formación de los alumnos en las facultades de medicina; internados, prácticas clínicas y formación de especialidades. Finalmente entrega propuestas para incorporar el manejo de las emociones en la formación de médicos.
Alpelisib Monotherapy for PI3K-Altered, Pretreated Advanced Breast Cancer: A Phase II Study
Authors: Savas Peter , Lo Louisa L. , Luen Stephen J. , Blackley Elizabeth F. , Callahan Jason , Moodie Kate , van Geelen Courtney T. , Ko Yi-An , Weng Chen-Fang , Wein Lironne , Silva Maria João , Bujak Andjelija Zivanovic , Yeung Miriam M. , Ftouni Sarah , Hicks Rodney J. , Francis Prudence A. , Lee Chee Khoon , Dawson Sarah-Jane , Loi Sherene 
Published: June 2022

Abstract

There is limited knowledge on the benefit of the α-subunit–specific PI3K inhibitor alpelisib in later lines of therapy for advanced estrogen receptor–positive (ER+) HER2− and triple-negative breast cancer (TNBC). We conducted a phase II multicohort study of alpelisib monotherapy in patients with advanced PI3K pathway mutant ER+HER2− and TNBC. In the intention-to-treat ER+ cohort, the overall response rate was 30% and the clinical benefit rate was 36%. A decline in PI3K pathway mutant circulating tumor DNA (ctDNA) levels from baseline to week 8 while on therapy was significantly associated with a partial response, clinical benefit, and improved progression-free-survival [HR 0.24; 95% confidence interval (CI), 0.083–0.67, P = 0.0065]. Detection of ESR1 mutations at baseline in plasma was also associated with clinical benefit and improved progression-free survival (HR 0.22; 95% CI, 0.078–0.60, P = 0.003).

Significance:
Alpelisib monotherapy displayed efficacy in heavily pretreated ER+ breast cancer with PIK3CA mutations. PIK3CA mutation dynamics in plasma during treatment and ESR1 mutations detected in plasma at baseline were candidate biomarkers predictive of benefit from alpelisib, highlighting the utility of ctDNA assays in this setting.
This article is highlighted in the In This Issue feature, p. 2007
Reassessing State Consent to Jurisdiction
Authors: Sparks Tom 
Published: June 2022

Abstract
In Monetary Gold Removed from Rome, the International Court of Justice first articulated the “Monetary Gold rule”: the principle that it cannot rule on cases in which the conduct of a State not party to the proceedings forms the “very subject-matter” of the dispute. That principle is taken to be a fundamental rule of international law, deriving its force from the sovereignty of States and the nature of the international legal system.
This article will dispute that claim, and will argue that the principle of consent underpinning Monetary Gold is an empty formalism. Through a comparison of the Court’s approach in its contentious and advisory jurisdictions, it will ask to what States consent and for what purpose they do so, when they “consent to jurisdiction”, and no satisfactory answer will be found. It will conclude that the focus on consent in international adjudication is discretionary.
History, Informally Speaking: Margolis’ Cultural Pragmatism
Authors: Grigoriev Serge 
Published: June 2022

Abstract
This essay aims to adumbrate the relationship between ordinary language, history, and cognition in Joseph Margolis’ pragmatist account of the historical constitution of the human, cultural world. It emphasizes the important connections between his arguments for the essentially practical grounding of all forms of cognitive activity; the existential primacy of the historically evolved ordinary language in the formation of aptly socialized human persons as well as of productively functioning human societies; the transformational role of consciousness in history, including the history of cognition; and the insuperable informality inherent in all philosophical attempts to justify our historically articulated norms of cognition and our way of life. Margolis’ analysis of these relationships claims to show that cultural tolerance and historical plasticity deserve to displace the philosophical ideas of invariance and fixity as the favored resources of conceptual and social stability. This recognition, on Margolis’s view, constitutes pragmatism’s distinctive promise and advantage.
The Transformation of the Meaning and Concept of Zoku 俗
Authors: Baba Mariko 
Published: June 2022

Abstract
This paper clarifies why the characters sei 聖 and zoku 俗 were adopted as the Japanese translations for the terms “sacred” and “profane,” respectively, as well as the circumstances in which these characters took on a diversity of meanings that go beyond those terms in contemporary society at large. While the character zoku has acquired various meanings over its long history, its fundamental nuance is the “general,” in contrast to the particular; accordingly, it only acquires a concrete meaning when contrasted with something else. This ambiguity led to its adoption as the translation of “profane,” as well as the continued expansion of the sei-zoku set’s meaning, resulting in a paired set that can refer to “something mysterious and something not mysterious.” When discussing the above, I also engage with international scholarship on how the cultural background of non-Western societies influenced the meanings and interpretations of imported modern Western concepts.
Washing Knives
Authors: Galman Sally Campbell 
Published: June 2022

Abstract
This comics-based research (cbr) piece focuses on the methodological awakenings that can result from disruption, insertion, and unruly publics. An anthropologist of childhood focusing on gender and preschool, the author reflects on how as anthropologists we often forget the locations of potential transformative power in our work as we are caught up in the everyday cycle of publication and communication, and how we might awaken to diverse purposes through seeing our purposes differently, if only for a moment. The piece asks us to “try on” scholarship as guerrilla art, and to consider what would happen if our work was an untethered public gift rather than a marooned, transactional experience shaped by the contours of academic business-as-usual.
“Such a Thing as the American Dream:” On Immigration, Affect, and the Election of Donald Trump
Authors: Frank-Vitale Amelia 
Published: June 2022

Abstract
In this article, I trace the structures of feeling underlying the 2106 election of Donald Trump as played out through the fear felt by immigrant communities and the fervor felt by anti-immigrant Trump supporters. The discourses of both groups rest on competing claims of the American Dream. Weaving together ethnographic data from fieldwork conducted among migrants and immigrants in Mexico, Honduras, and the United States with expressions of anti-immigrant sentiment as evidenced through online interactions, I explore the intersections and outline the divergences in the ways in which the American Dream is invoked, contested, twisted, and rejected. I use the idea of the American Dream as a fulcrum for the hopes, dreams, and feelings of immigrants and nativists alike. As we face the next election, I ask: whose American Dream as a structure of feeling is the emergent structure, and whose is fading out?
The Global Pattern and Development Trends and Directions on the Drought Monitoring Research from 1983 to 2020 by Using Bibliometric Analysis
Authors: Wang Jianshun , Zhang Qiang , Zhang Liang , Wang Ying , Yue Ping , Hu Yanbin , Ye Peilong 
Published: June 2022

Abstract
As impacted by climate change and further global warming, drought turns out to be the most frequent meteorological extreme event worldwide, which severely affects agriculture, ecosystem, water management, and even human survival. In this study, the global pattern and development trends and directions on drought monitoring were presented based on Web of Science database by conducting a bibliometric analysis from 1983 to 2020. The following conclusions were drawn. 1) The United States and China were found as the most productive and influential nations, accounting for 24.63% and 14.30% in publication outputs and taking up 5,023 and 2,040 in local citations, respectively. 2) Chinese Academy of Science was reported as the core institution with 5.73% publication outputs and 829 local citations. 3) Remote Sensing of Environment and Remote Sensing were found as the most influential journals and the most productive journals with 1,045 local citations and 210 publication outputs, respectively. 4) Agricultural drought profoundly affecting food security was found as the most concerning drought type in the world. The drought monitoring research mainly focus on the research and development of drought index, the response of terrestrial ecosystems to drought, and the trends and dynamics of drought in context of climate change. This study explored key findings, contradictions, and limitations of drought monitoring studies were summarized and explored. In addition, the development trend and research direction of drought monitoring research in the future were also explored.
Effects of a theory-based advance care planning intervention for nursing homes: A cluster randomized controlled trial
Authors: Pivodic Lara , Wendrich-van Dael Annelien , Gilissen Joni , De Buyser Stefanie , Deliens Luc , Gastmans Chris , Vander Stichele Robert , Van den Block Lieve 
Published: June 2022

Background: Uptake of advance care planning in routine nursing home care is low. Through extensive literature review, theoretical development, and stakeholder involvement, we developed the ACP+ intervention. Aims: To evaluate the effects of ACP+ on the knowledge and self-efficacy (confidence in own skills) of nursing home care staff concerning advance care planning. Design: Cluster randomized controlled trial, conducted between February 2018 and January 2019 (NCT03521206, clinicaltrials.gov). ACP+ is a multicomponent intervention aimed at training and supporting nursing home staff and management in implementing advance care planning in nursing home practice through a train-the-trainer approach over 8 months. Fourteen nursing homes were randomized using a matched-pairing strategy, seven received ACP+, seven followed usual practice. Analyses (intention-to-treat) involved linear mixed models. Setting/participants: Nursing homes in Flanders (Belgium). Results: 694 of 1017 care staff (68% response rate) at baseline and 491 of 989 care staff (50%) post-intervention (8 months) returned questionnaires. Post-intervention, care staff’s self-efficacy concerning advance care planning was significantly higher in the intervention than in the control group (baseline-adjusted mean difference 0.57; 95% CI 0.20–0.94; p = 0.003; Cohen’s d = 0.30). Advance care planning knowledge (95% CI 0.95–1.15; p = 0.339; ratio: 1.04) did not differ significantly between groups. Conclusions: The ACP+ intervention for nursing homes improved care staff’s self-efficacy but not their knowledge concerning advance care planning. Considering the comprehensive and multi-component approach used, these effects were smaller than expected. Reasons for this may be related to the chosen follow-up period, outcomes and measurements, or to the intervention itself and its implementation.
Upregulation of CCT3 predicts poor prognosis and promotes cell proliferation via inhibition of ferroptosis and activation of AKT signaling in lung adenocarcinoma
Authors: Wang Kun , He Jian , Tu Changling , Xu Hui , Zhang Xugang , Lv Yongchang , Song Chao 
Published: June 2022

Abstract
Background
Chaperonin containing TCP1 subunit 3 (CCT3) acts as an oncogene in cancers, whereas its role and underlying mechanisms in lung adenocarcinoma (LUAD) are poorly understood. This study investigated the clinical relevance and function of CCT3 in LUAD.

Methods
Clinical relevance of CCT3 in LUAD and lung squamous cell carcinoma (LUSC) was analyzed based on TCGA database. qRT-PCR and Western blot were used to detect mRNA and protein expression, respectively. CCK8 and colony formation were performed to measure cell viability. PI and PI/Annexin V-FITC assay kit was used to determine cell cycle and cell death, respectively. Luciferase activity was performed to check whether CCT3 regulated slc7a11’s transcription activity. Ferroptosis was determined by incubating the cells with ferroptosis and apoptosis inducer, their inhibitor and autophagy inhibitor, followed by cell viability examination.

Results
We found that CCT3 was overexpressed in LUAD and LUSC tissues. Overexpression of CCT3 predicted the poor prognosis of LUAD patients. Loss-of-function and gain-of-function experiments demonstrated that CCT3 promoted the proliferation and colony formation of LUAD cells. In addition, CCT3 promoted cell cycle progression and suppressed slc7a11-mediated cell ferroptosis, but not apoptosis. We also found that CCT3 activated AKT. MK2206 significantly reduced the viability of CCT3 overexpressed LUAD cells, while had smaller inhibitory effect on the proliferation of control cells, suggesting that CCT3 dictates the sensitivity of LUAD cells to AKT inhibition.

Conclusion
Our study demonstrates that CCT3 contributes to the proliferation and growth of LUAD cells through inhibition of ferroptosis and activation of AKT.