bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perahu Sampah sebagai Alternatif Pengangkut/Pengumpul Sampah di Lingkungan Bantaran Sungai Beting Permai Pontianak
Authors: Arena Azza , Syafarudin Syafarudin , Widhiastuti Rahayu 
Published: March 2022

Produksi sampah rumah tangga setiap hari semakin meningkat seiring dengan bertambahnya jumlah produk dan pola konsumsi masyarakat. Hal yang harus dilakukan untuk mengatasi peningkatan volume sampah tersebut adalah dengan cara, mengurangi volume sampah dari sumbernya melalui pengelolaan persampahan dengan pemberdayaan masyarakat. Studi tentang pengelolaan sampah di Pemukiman Beting Permai bertujuan untuk: (1) memperoleh gambaran proses perencanaan dan pengelolaan sampah teknik operasional dengan peran serta masyarakat, (2) menginventarisir tantangan dan peluang dalam pengelolaan sampah rumah tangga, (3) mengajukan usulan pengelolaan sampah berskala rumah tangga. Jenis studi ini adalah deskriptif kuatitatif, yaitu studi yang bermaksud mendeskripsikan fenomena yang terjadi dilokasi studi. Teknik pengumpulan data meliputi wawancara, observasi dan dokumentasi, sedangkan analisis data menggunakan teknik deskriptif kuatitatif. Hasil studi menyimpulkan bahwa pengelolaan dan peran serta masyarakat Pemukiman Beting Permai dapat mereduksi timbulan sampah yang dibuang ke TPS atau TPA, namun belum optimal dilaksanakan baik dalam pemilahan dan atau dalam pengomposan karena keterbatasan sarana dan prasarana. Komposisi timbulan sampah berdasarkan pengambilan dan pengukuran terdiri dari: sampah organik 87% dan sampah anorganik 13%. Dari 79 sampel yang terkumpul dan hasil pengukuran maka timbulan sampah didapat adalah 734,341 kg/hari. Dengan timbulan sampah orgaik 639,148 kg/hari dan anorganik 95,193 kg/hari. Pola pengelolaan sampah pemukiman yang disarankan sampah dari sumber (tiap rumah) dipisahkan organic dan anorganik, dan tiap rumah tangga memiliki wadah sampah individual atau komunal. Berdasarkan hasil pola pengelolaan sampah Pemukiman Beting Permai adalah (1) kapasitas rencana wadah sampah komunal untuk rumah tangga yaitu 1 m3, (2) volume rencana pengangkutan sampah dari sumber ke TPS menggunakan sampan 1,2 m3, (3) volume rencana pengumpul atau tempat pengumpul sementara (TPS) adalah 6,28 m3. Hasil pengelolaan sampah masih sangat kurang. dan berdasarkan persepsi masyarakat, sebagian besar dinilai oleh masyarakat masih kurang baik karena dipengaruhi antara lain jumlah personil dan sarana prasarana masih sangat terbatas atau tidak ada, operasional pengangkutan yang belum optimal, masih kurang jelasnya pembagian tugas terutama pada sistem pewadahan, pemindahan, pengumpulan dan pengangkutan, masyarakat belum sepenuhnya mendukung pengelolaan sampah. Hasil analisis sampah Pemukiman Beting Permai terletak di Bantara Sungai yang image masyarakat sungai sebagai TPS besar maka Pemukiman Beting Permai perlu memiliki pewadahan sampah komunal yang terletak ditepi gertak atau jalan dimana masing-masing RT memerlukan 2 unit pewadah sampah komunal dan 1 unit sampan sampah, ritasi pengangkutannya 3 hari dengan pemisahan sampah oganik dan anorganik.
Pediatric brainstem cavernous malformations: 2-center experience in 40 children
Authors: Velz Julia , Özkaratufan Sena , Krayenbühl Niklaus , Beccaria Kevin , Akeret Kevin , Attieh Christian , Ghannam Boulos , Guida Lelio , Benichi Sandro , Bozinov Oliver , Puget Stephanie , Blauwblomme Thomas , Regli Luca 
Published: March 2022

OBJECTIVE
Brainstem cavernous malformations (BSCMs) are relatively uncommon, low-flow vascular lesions in children. Given the paucity of data, guidelines regarding the clinical management of BSCMs in children are lacking and the surgical indication is most commonly based on an individual surgeon’s judgment and experience. The goal in this study was to evaluate the clinical behavior of BSCMs in childhood and the long-term outcome in children managed conservatively and surgically.

METHODS
This was an observational, retrospective study including all children with BSCMs who were followed at 2 institutions between 2008 and 2020.

RESULTS
The study population consisted of 40 children (27 boys, 67.5%) with a mean age of 11.4 years. Twenty-three children (57.5%) were managed conservatively, whereas 17 children (42.5%) underwent resection of BSCMs. An aggressive clinical course was observed in 13 children (32.5%), who experienced multiple hemorrhages with a progressive pattern of neurological decline. Multiple BSCMs were observed in 8 patients, of whom 3 patients presented with a complex of multiple tightly attached BSCMs and posed a significant therapeutic challenge. The overall long-term outcome was favorable (modified Rankin Scale [mRS] scores 0–2) in 36 patients (90%), whereas an unfavorable outcome (mRS scores 3 and 4) was seen in 4 children (10%). An mRS score of 5 or 6 was not observed. The mean (± SD) follow-up was 88.0 (± 92.6) months.

CONCLUSIONS
The clinical course of BSCMs in children is highly variable, with benign lesions on the one hand and highly aggressive lesions with repetitive hemorrhages on the other. Given the greater life expectancy and the known higher functional recovery in children, surgical treatment should be considered early in young patients presenting with surgically accessible lesions and an aggressive clinical course, and it should be performed in a high-volume center.
Zingiber officinale ameliorates diabetic nephropathy and hepatotoxicity in rats by preventing tissue injury and controlling liver/kidney function
Authors: Hamman Luteino Lorna , Garba Sani Hyedima , Jacks Tamunotonye Watson , Zirahei Joseph Vandi , Dibal Nathan Isaac , Attah Martha Orendu Oche 
Published: March 2022

BACKGROUND: Chronic hyperglycemia results in decrease glucose metabolism leading to nephropathy, hepatotoxicity and neuropathy. Diabetic complications are regarded globally as one of the leading cause of disability and mortality. OBJECTIVE: The study aims to evaluate the role of Zingiber officinale (ZO) on diabetic nephropathy and hepatotoxicity in rats. METHODS: Thirty diabetic rats and six non-diabetic rats were distributed into six groups ( n = 6). Group 1 & 2 (nondiabetic and diabetic) received distilled water at 1 ml/kg. Groups 3–5 received (12.5, 25& 50) mg/kg of ZO respectively while group 6 received 100 mg/kg metformin. All treatments lasted for 28 days and rats were euthanized on day 29. Biochemical parameters, kidney and liver histology were evaluated. RESULTS: No significant change ( P > 0.05) was noticed in blood glucose and creatinine levels of diabetic rats treated with 25 mg/kg ZO compared to control. The liver of 25 mg/kg ZO treated diabetic rats showed mild distortion of hepatocytes while kidneys of ZO treated diabetic rats showed mild distortion of renal tubules with few collagen deposits and intact Bowman’s capsule. CONCLUSIONS: ZO ameliorates diabetic complications by regulating biochemical parameters and preventing renal tubules and hepatocytes damage in rats.
Application of Expectation Maximization Algorithm in Estimating Parameter Values of Maximum Likelihood Model
Authors: Simarmata Justin Eduardo 
Published: March 2022

Parameter estimation is an estimation of the population parameter values ​​based on data or samples of population. Parameter estimation can be solverd by several methods, one of which is the Maximum Likelihood method. The focus of this research is to estimate the parameter value of a normal distribution data with Maximum Likelihood based on iteration algorithm. The iteration algorithm that will be used is the Expectation Maximation Algorithm with help of Matlab 2016a program. Based on the results obtained that the estimation value of the parameter and for an accident data in Indonesia based on age group with using Expectation Maximization algorithm is and with 2 iterations.
PENGARUH MEDIA PEMBELAJARAN MONOPOLY GAME SMART TERHADAP KEMANDIRIAN DAN HASIL BELAJAR SISWA PADA PEMBELAJARAN IPS
Authors: Ria Kurniasari  
Published: March 2022

Penelitian ini bertujuan untuk mengetahui pengaruh media pembelajaran monopoly game smart terhadap kemandirian dan hasil belajar siswa pada pembelajaran IPS Kelas V SD Negeri Legok II Sumedang Tahun Pelajaran 2018/2019. Bentuk penelitian ini adalah Quasi eksperimental design dengan desain one group pretest-postest. Berdasarkan observasi yang dilakukan sebelumnya, didapatkan kelas V sebagai kelas eksperimen. Alat pengumpulan data yang digunakan terdiri dari tes tertulis dan lembar observasi. Berdasarkan analisis data skor menggunakan uji paired t-test (α=5%) diperoleh skor rata-rata hasil belajar pada pretest 61,2 dan posttest 75,2. Kemudian diperoleh skor rata-rata observasi kemandirian yaitu 11,78 untuk pretest dan 20,79 untuk posttest. Hal tersebut menunjukkan adanya perbedaan yang signifikan dari penggunaan media pembelajaran monopoly game smart terhadap kemandirian dan hasil belajar siswa.
Análise da balneabilidade das praias de Itanhaém (São Paulo, Brasil): percepções de uma série de dados de monitoramento de longo prazo
Authors: Freitas Gabriel Sousa de , Arruda Regina de Oliveira Moraes , Rosini Edna Ferreira , Osti João Alexandre Saviolo 
Published: March 2022

A qualidade das águas das praias nas cidades litorâneas é essencial para a saúde pública. O conceito de balneabilidade é aplicado quando do contato humano prolongado e direto com a água e onde existe a possibilidade de ingestão da mesma, como nas praias. Por isso torna-se importante entender balneabilidade das praias litorâneas tanto como questão de saúde, como para a indústria do turismo. O município de Itanhaém, objeto do estudo está localizado no litoral sul do estado de São Paulo, na Região Metropolitana da Baixada Santista. O objetivo desta pesquisa foi analisar as condições de balneabilidade de doze praias do município de Itanhaém, SP-Brasil, frente aos corpos hídricos, que chegam nas praias, e as condições de saneamento, entre 2010 e 2020. Para tanto foram utilizados dados secundários disponibilizados pela Companhia Ambiental do Estado de São Paulo. A maioria das praias de Itanhaém-SP tem valores anuais de balneabilidade considerados regulares, no período estudado. Foi observada uma melhora na qualidade da água dos corpos hídricos que chegam a essas praias, que pode ser um reflexo do aumento de domicílios com coleta de esgoto. Espera-se que com a melhoria dos serviços de saneamento, as praias se tornem mais seguras aos turistas e moradores do município.
A Broad-Range Disposable Electrochemical Biosensor Based on Screen-Printed Carbon Electrodes for Detection of Human Noroviruses
Authors: Wang Nan , Pan Guiying , Guan Shimin , Rong Shaofeng , Wang Dapeng , Gao Zhiyong , Tian Peng , Li Qianqian 
Published: March 2022

Human noroviruses (HuNoVs) are the major non-bacterial pathogens causing acute gastroenteritis in people of all ages worldwide. No stable culture system in vitro is available for routing the detection of multiple strains of HuNoVs. A simple and rapid method for detection of HuNoVs is of great significance for preventing and controlling this pathogen. In this work, an electrochemical biosensor for sensitive and fast detection of HuNoVs was constructed based on a screen-printed carbon electrode (SPCE). Gold nanoparticles and protein-A were applied on the SPCE surface for enhancement of the electrical signals and the linkage of antibodies with a fixed orientation, respectively. A monoclonal antibody (MAb) against the S domain protein of the viral capsid (VP1) was further immobilized on the SPCE to bind HuNoVs specifically. The binding of VP1 to the coated MAbs resulted in the reduction of conductivity (current) measured by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The reduction in the current was correlated to the concentration of VP1/HuNoVs. The detection limitation of Genogroup I.1 (GI.1) VP1 and Genogroup II.4 (GII.4) VP1 was 0.37 ng/ml (≈1.93×107 HuNoVs/mL) and 0.22 ng/ml (≈1.15×107 HuNoVs/mL), respectively. The detection limitation of both GI and GII HuNoVs in clinical fecal samples was 104 genomic copies/mL. The results could be obtained in 1 h. We demonstrated that this disposable electrochemical biosensor was a good candidate for rapid detection of different genogroup and genotype HuNoVs.
Angiogenesis-Related Gene Signature-Derived Risk Score for Glioblastoma: Prospects for Predicting Prognosis and Immune Heterogeneity in Glioblastoma
Authors: Wang Gang , Hu Jin-Qu , Liu Ji-Yuan , Zhang Xiao-Mei 
Published: March 2022

Background: Glioblastoma multiforme (GBM) is the most common malignant tumor in the central nervous system with poor prognosis and unsatisfactory therapeutic efficacy. Considering the high correlation between tumors and angiogenesis, we attempted to construct a more effective model with angiogenesis-related genes (ARGs) to better predict therapeutic response and prognosis.Methods: The ARG datasets were downloaded from the NCBI-Gene and Molecular Signatures Database. The gene expression data and clinical information were obtained from TCGA and CGGA databases. The differentially expressed angiogenesis-related genes (DE-ARGs) were screened with the R package “DESeq2”. Univariate Cox proportional hazards regression analysis was used to screen for ARGs related to overall survival. The redundant ARGs were removed by least absolute shrinkage and selection operator (LASSO) regression analysis. Based on the gene signature of DE-ARGs, a risk score model was established, and its effectiveness was estimated through Kaplan–Meier analysis, ROC analysis, etc.Results: A total of 626 DE-ARGs were explored between GBM and normal samples; 31 genes were identified as key DE-ARGs. Then, the risk score of ARG signature was established. Patients with high-risk score had poor survival outcomes. It was proved that the risk score could predict some medical treatments’ response, such as temozolomide chemotherapy, radiotherapy, and immunotherapy. Besides, the risk score could serve as a promising prognostic predictor. Three key prognostic genes (PLAUR, ITGA5, and FMOD) were selected and further discussed.Conclusion: The angiogenesis-related gene signature-derived risk score is a promising predictor of prognosis and treatment response in GBM and will help in making appropriate therapeutic strategies.
Valosin Containing Protein as a Specific Biomarker for Predicting the Development of Acute Coronary Syndrome and Its Complication
Authors: Xu Chenchao , Yu Bokang , Zhao Xin , Lin Xinyi , Tang Xinru , Liu Zheng , Gao Pan , Ge Junbo , Wang Shouyu , Li Liliang 
Published: March 2022

BackgroundAcute coronary syndrome (ACS) consists of a range of acute myocardial ischemia-related manifestations. The adverse events of ACS are usually associated with ventricular dysfunction (VD), which could finally develop to heart failure. Currently, there is no satisfactory indicator that could specifically predict the development of ACS and its prognosis. Valosin-containing protein (VCP) has recently been proposed to protect against cardiac diseases. Hence, we aimed to assess whether VCP in serum can serve as a valuable biomarker for predicting ACS and its complication.MethodsHuman serum samples from 291 participants were collected and classified into four groups based on their clinical diagnosis, namely healthy control (n = 64), ACS (n = 40), chronic coronary syndrome (CCS, n = 99), and nonischemic heart disease (non-IHD, n = 88). Clinical characteristics of these participants were recorded and their serum VCP levels were detected by enzyme-linked immunosorbent assay (ELISA). Association of serum VCP with the development of ACS and its complication VD was statistically studied. Subsequently, GWAS and eQTL analyses were performed to explore the association between VCP polymorphism and monocyte count. A stability test was also performed to investigate whether VCP is a stable biomarker.ResultsSerum VCP levels were significantly higher in the ACS group compared with the rest groups. Besides, the VCP levels of patients with ACS with VD were significantly lower compared to those without VD. Multivariate logistic regression analysis revealed that VCP was associated with both the risk of ACS (P = 0.042, OR = 1.222) and the risk of developing VD in patients with ACS (P = 0.035, OR = 0.513) independently. The GWAS analysis also identified an association between VCP polymorphism (rs684562) and monocyte count, whereas the influence of rs684562 on VCP mRNA expression level was further verified by eQTL analysis. Moreover, a high stability of serum VCP content was observed under different preservation circumstances.ConclusionValosin-containing protein could act as a stable biomarker in predicting the development of ACS and its complication VD.
Seasonal Variation: A Non-negligible Factor Associated With Blood Pressure in Patients Undergoing Hemodialysis
Authors: Wu Zhibin , Lan Shan , Chen Chengqiang , Zhang Xiuan , Zhang Yazhen , Chen Shanying 
Published: March 2022

ObjectiveTo investigate a seasonal variation in blood pressure (BP) for patients undergoing hemodialysis (HD).MethodsIn this retrospective study, we exported all BP measurements from the information system to investigate a seasonal variation of BP. We also investigated a seasonal variation in BP for patients of different gender types, of different age groups, with diabetic nephropathy (DN), and with non-DN having HD. Multiple linear regression models were used to explore the associations between BP and climatic parameters.ResultsIn 2019, a total of 367 patients had received HD therapy in the Longwen HD unit. We included nearly 40,000 pre-dialysis BP measurements. The result of our study demonstrated a clear seasonal variation in pre-dialysis BP in general patients with HD, in male and female patients, and patients with DN and non-DN. December seemed to be a peak in the values of pre-dialysis systolic BP (SBP) and diastolic BP (DBP). The nadir values of pre-dialysis SBP and DBP were observed in June and July, respectively. A difference between peak and nadir values of BP is 3.81/2.20 mmHg in patients undergoing HD. Maximal seasonal variation in BP is 9.03/5.08 mmHg for patients with DN. A significant association of SBP and DBP with climatic parameters was found in this study. Pre-dialysis BP was inversely correlated with outdoor temperature, daytime length, and relative humidity.ConclusionA clear seasonal variation in BP is observed for patients with HD. Pre-dialysis SBP and DBP are inversely associated with outdoor temperature, daytime length, and relative humidity. The magnitude of a seasonal variation in BP increases in patients with DN.
Initial Invasive or Conservative Strategy in Heart Failure With Preserved Ejection Fraction and Coronary Artery Disease
Authors: Gu Jun , Pan Jian-an , Zhang Jun-feng , Wang Chang-qian 
Published: March 2022

BackgroundIn patients with both heart failure with preserved ejection fraction (HFpEF) and coronary artery disease (CAD), whether adopting an initial invasive strategy benefits better in clinical outcomes compared with those who received an initial conservative strategy remains inconclusive.MethodsWith data from the heart failure (HF) cohort study, we analyzed patients who had HFpEF and CAD amenable to the invasive intervention using propensity score matching of 1:1 ratio to compare the initial invasive strategy and the initial conservative strategy of medical therapy alone. The primary outcome was the composite endpoints of all-cause mortality or cardiovascular hospitalization, and the secondary outcome was all-cause mortality or cardiovascular hospitalization.ResultsOf 1,718 patients, 706 were treated with the invasive strategy and 1,012 with the conservative strategy initially. Propensity score matching was used to assemble a matched cohort of 1,320 patients receiving the invasive intervention (660 patients) or the medical therapy alone (660 patients). With a follow-up of 5 years, 378 (57.3%) in the invasive-strategy group and 403 (61.1%) in the conservative-strategy group reached the primary endpoint, and there was no significant difference in the rate of the primary endpoint (P = 0.162). The initial invasive strategy only improved the secondary outcome of cardiovascular hospitalization (P = 0.035). Also, the multivariable Cox regression model revealed that antiplatelet therapy, angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker (ACEI/ARB), or statin prescription was associated with a decreased risk of the primary outcome.ConclusionIn this well-profiled, propensity-matched cohort of patients with HFpEF and CAD, the addition of invasive intervention to medical therapy did not improve the long-term composite of all-cause mortality or cardiovascular hospitalization.
Evolving Antithrombotic Treatment Patterns for Patients With Nonvalvular Atrial Fibrillation and Acute Coronary Syndrome or Underwent Percutaneous Coronary Intervention in China: A Cross-Sectional Study
Authors: Suo Ni , Yang Yan-min , Wang Juan , Zhang Han , Shao Xing-hui , Wu Shuang , Zhu Jun 
Published: March 2022

ObjectiveAntithrombotic therapy in patients with nonvalvular atrial fibrillation (NVAF) concomitant with the acute coronary syndrome (ACS) or underwent percutaneous coronary intervention (PCI) is challenging and has evolved in recent years. However, real-world data on this issue about antithrombotic regimens at discharge and its evolving trend were relatively scarce, especially in China.MethodsA total of 2,182 patients with NVAF and ACS/PCI were enrolled from 2017 to 2019. A total of 1,979 patients were finally analyzed and divided in three sequential cohorts: cohort 1 (2017), n = 674; cohort 2 (2018), n = 793; and cohort 3 (2019), n = 512. Baseline characteristics and antithrombotic therapy at discharge were analyzed by cohort.ResultsIn our cross-sectional study, the majority of patients (59.6%) received dual antiplatelet therapy (DAPT). Over the 3 years, DAPT prescription reduced from nearly 70% to &lt;50% (P trend &lt; 0.001), while triple therapy (TT)/double therapy (DT) increased from 27.2 to 50.0% (P trend &lt; 0.001). This trend was also seen in different subgroups stratified by CHA2DS2-VASc score, HAS-BLED score, coronary artery disease type, or management type, and was validated after multivariate adjustment. Persistent atrial fibrillation and history of congestive heart failure, hypertension, diabetes mellitus, and stroke/transient ischemic attack/systemic embolism were the independent predictors of TT/DT use, while ACS, PCI, or advanced chronic kidney disease was related with more DAPT prescription.ConclusionThere is a shift of antithrombotic regime at discharge for patients with NVAF with recent ACS/PCI with reducing DAPT prescription and increasing TT/DT prescription. While the appropriate antithrombotic regimen for patients with NVAF having ACS/PCI is still underused in China.