bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on Human Resource Management of Science and Technology Enterprises
Authors: Li Yueqin 
Published: April 2022

In the era of modern knowledge economy,the competition of scientific and technological enterprises is essentially the
competition of talents,and human resources are the most important enterprise resources.Science and technology enterprises are
facing various competitions.In order to survive in the fierce market competition,they must be good at improving the utilization rate
of various resources,especially human resources,as the most important and key resource for enterprise development,strengthen the
ability and efficiency of human resources management,and orderly carry out talent recruitment,training and Performance appraisal
and salary management enable the talents of the enterprise to perform their duties,give full play to their talents,give full play to the
dynamic role of employees and be people-oriented.
Book Review:Pragmatic Identity: How to Do Things with Words of Identity
Authors: Wei Zhangting 
Published: April 2022

Pragmatic Identity: How to Do Things with Words of Identity firstly defined identity as pragmatic identity in the
field of pragmatics by Chinese scholar Chen Xinren, and systematically constructs the mechanism of pragmatic identity. It is
an innovative attempt by Chinese scholars to construct a native pragmatic theoretical framework, which can provide a more
appropriate theoretical basis and research path for identity research in the context of Chinese language.
Exploration on the Construction Path of Interdisciplinary About Digital-intelligence Financial Major Under the Background of Digitalization Reform
Authors: Yan Yuwei , Zhang Jian , Zhang Xiang 
Published: April 2022

Based on the education orientation and existing resources of Application-oriented colleges and universities, it adopts
the mode of major cultivation, Direction Specialty to reconstruct the training program of intelligent financial talents. It
develops intelligent financial courses through independent research and development, course co-construction and other ways, and
independently cultivates and creates intelligent teachers. It has accumulated certain experience in professional construction and
reform. It has important strategic significance and popularization value for the development of economics and management in
applied universities.
Research on Blended Teaching Cultivation for International Students
Authors: Cui Shirong 
Published: April 2022

The outbreak of global epidemic has promoted the development of blended teaching model.Relying on the Internet,artificial
intelligence and other new technologies,online and offline blended teaching is booming.As the largest destination country of
international students in Asia,China’s education for international students should also follow the developmental direction of the
world’s education and innovate educational and teaching models.Based on this,this paper studies the blended teaching and training
mode for international students to create”First-class ourses”,improve the quality of education and teaching,attract more foreigners
to study in China,cultivate more friendly people who”know China,befriend China and love China”and provide more support for
the internationalized development of“the Belt and Road”initiative.
The Exploration on the Path of Improving the Quality of Innovation and Entrepreneurship Education through the Integration of Industry and Education in Higher Vocational Medical Majors under the New Media Environment
Authors: Liu Guangmin 
Published: April 2022

In higher vocational medical majors, it is of great practical significance to pay attention to and improve the quality of
innovation and entrepreneurship education. On the one hand, it can promote the smooth employment of higher vocational students.
On the other hand, the overall construction of higher vocational medical majors can be strengthened to promote the development of
various departments in higher vocational colleges. This article mainly carries out discussion around “the importance of improving
the quality of innovation and entrepreneurship education of higher vocational medical majors”, “the path of improving the
quality of innovation and entrepreneurship education through the integration of production and education in higher vocational
medical majors under the new media environment “, focuses on combining with the new media environment, and analyzes how
to improve the quality of innovation and entrepreneurship education of higher vocational medical majors under the background
of industry-education integration, hoping to export outstanding talents for enterprises and society through high-quality innovation
and entrepreneurship education system.
Research on Gender Factors Related to Career Development in Hospitality Management in China
Authors: Gong Mengjie 
Published: April 2022

Owing to the continuous development of China’s market-oriented economy,the service industry has become a dominant
industry in China.As the pillar sector of the service industry,hotels have also flourished unprecedentedly.Human resources are the
key for hotels to maintain sustainable development,and to be in an invincible position amongst fierce competition.According to
statistics,female managers accounted for two thirds of the total managers in hotel industry in China.The study found that social
culture affects people’s perception on women managers’ability and the glass ceiling effect affects women’s career development
in hotel industry in China.The findings suggest that there is room for China’s hotel industry to review the effect of barriers on
women’s career development.
Evaluation model of anti sandstorm effect of Saihan dam based on TOPSIS good and bad solution distance method
Authors: Yu Deqiang , Zhang Haobo , Lu Runsheng 
Published: April 2022

This paper starts from the conditions of sandstorm formation, collected the relevant data of Beijing's air quality, strong
wind weather, precipitation and other indicators in recent years, strong wind, dust volume, air state, water content, vegetation
abundance, and environmental damage degree in surrounding areas were selected as the judging indexes, after data preprocessing,
a factor analysis model was established to extract three comprehensive indicators: strong wind weather, air quality and dust
volume, the comprehensive index was added into TOPSIS model to calculate the score. Finally, by comparing the score, the effect
of the ecological environment restoration of Saihan dam on the sand storm resistance in Beijing was quantitatively obtained.
Design and Analysis of Transmission System of Pure Electric Vehicle
Authors: Zhang Xiaoqing 
Published: April 2022

The number of internal combustion vehicles continues to rise, which not only brings energy crisis, but also tail gas brings
great environmental harm. At present, the new energy vehicle represented by pure electric has attracted the attention of all sectors
of society. It not only effectively solves the problem of energy shortage, but also reduces the harm to the environment. This paper
will briefly introduce the transmission system of pure electric vehicle, and analyze its evaluation indexes and design parameters,
which is of great significance to establish the technology transformation strategy of pure electric drive.
Observation on the Improvement of Cardiopulmonary Function in Children by Increasing Load Exercise
Authors: Liu Long 
Published: April 2022

Objective: To investigate the effect of increasing load exercise on the improvement of children’s cardiopulmonary
function.Methods: 80 students from a primary school were selected as experimental subjects and randomly divided into two
groups, namely control group (40) for routine exercise training, and experimental group (40) for increasing load exercise training.
After training for 6 months, the scores of heart function and lung function of the two groups of students were compared.Results:
Before training, there was no significant difference in each index of heart function between the two groups (P>0.05).After 6
months of follow-up training and observation, the results showed that the heart function index of the experimental group students
was significantly better than the control group, the difference of data comparison was statistically significant (P0.05);The difference of lung function
in the experimental group was statistically significant (P
The development of the university's readers' culture
Authors: Maldybaevna Aituarova Aziza , Absatovna Absatova Marfuga , Ivanovna Klimenko Tatyana , Bisenovna Abdrakhmanova Roza , Mentay Shagyrbayeva , Nesipbekovna Ospanbekova Meirgul 
Published: April 2022

The act of reading affects people in individual and social life. The purpose of this research is the evaluation of student opinions to develop reader culture in universities. Research data were collected through a semi-structured interview form developed by the researchers. Participants in this research included 60 students studying at various universities in Kazakhstan in the 2021-2022 academic year. It has been concluded that the reading habits of the university students participating in the research are at a moderate level, the students do not see themselves as highly qualified readers, and the reading habits of female students are relatively higher than male students. While the type of poetry is mostly preferred by female students, a small portion of male students stated that they read comics. Based on the research findings, it has emerged that universities should organize activities to increase students' reading culture.

Keywords: Reader culture; reading culture; reading habits; university students.
The Performance of Microalgae (Nannochloropsis sp., Tetraselmis sp. and Dunaliella sp.) on White Shrimp (Litopenaeus vannamei) Wastewater Cultivation Media
Authors: Santanumurti Muhammad Browijoyo , Khanza Santrika , Abidin Zaenal , Putri Berta , Hudaidah Siti 
Published: April 2022

Microalgae have an important role in supporting the development of aquaculture because it can be used as natural feed. However, its culture requires an expensive cost because of the nutrient media. To reduce the cost, the media can be replaced by using wastewater from white shrimp (Litopenaeus vannamei) culture. This research was aimed to find out the performance of microalgae (Nannochloropsis sp., Tetraselmis sp. and Dunaliella sp.) cultured on white shrimp wastewater. The performance was measured by the growth, density, and ability to reduce nitrate and phosphate. The experimental design used in this study was a Completely Randomized Design with three treatments and three replications. The treatments were A (Nannochloropsis sp. cultured in white shrimp wastewater), B (Tetraselmis sp. cultured in white shrimp wastewater), and C (Dunaliella sp. cultured in white shrimp wastewater). The density population of Nannochloropsis sp., Tetraselmis sp. and Dunaliella sp. were tested by ANOVA. ANOVA was used to assess the density population of Nannochloropsis sp., Tetraselmis sp., and Dunaliella sp., which was then followed by Duncan's test. The results showed that wastewater from white shrimp aquaculture could be used as a medium culture for Nannochloropsis sp., Tetraselmis sp. and Dunaliella sp. It also maintain good water parameter quality in media. Nannochloropsis sp. was the microalgae that produced the highest density of 34.5 x 104 ind/mL when cultured on waste water from white shrimp culture. Nannochloropsis sp. may also reduce nitrate and phosphate content by up to 76 and 61.37 percent, respectively.
PROCESS OF 3D PRINTING IN ONLINE EDUCATION
Authors: Haidar Nataliia , Zavolodko Ganna , Pustovoitov Pavlo 
Published: April 2022

The subject of the review is methodology of the subsystem verification and printing 3 D -model online learning system mixed type. To do this, a review of analogues, technologies, stages of printing were identified. Due to the development of technology, the educational process is being transformed. Education uses blended learning, part of which is distance learning. The object of research is use of additive technologies, which can make the learning process more motivating. Thus, if in distance education there is an opportunity to develop a 3D model online, check it for fidelity, send the model to print, it optimizes the learning process. The aim is to design with IP topics that uses the additive technologies in the educational process. Methods used: IDEF- diagram describing the function of the system; authentication rules, verification of 3 D models, sending the model to print, selecting a device online, and basic screen forms. Conclusions. The development of innovative thinking in higher education students should become a priority of modern higher education, and the introduction of new elements in modern education is inevitable. And given the development of 3D printing technologies, additive technologies are the most promising for the use of visualization in online and mixed teaching.
Abnormal Lipid Profiles in Nontraumatic Osteonecrosis of the Femoral Head
Authors: Baek Seung-Hoon , Kim Kwang-Hwan , Lee Won Kee , Hong Wonki , Won Heejae , Kim Shin-Yoon 
Published: April 2022

Background:
Abnormal lipid metabolism may play an important role in the development of nontraumatic osteonecrosis of the femoral head (ON). By comparing lipid biomarkers in patients with ON and osteoarthritis (OA) after propensity score matching, we sought to reveal (1) common lipid biomarkers that are abnormal in ON regardless of the etiology and (2) specific lipid biomarkers associated with ON according to the etiology.

Methods:
Among 2,268 patients who underwent primary THA, 1,021 patients were eligible for this study. According to the Association Research Circulation Osseous criteria, ON was classified as either idiopathic (n = 230), alcohol-associated (n = 293), or glucocorticoid-associated ON (n = 132). Most common cause of OA was hip dysplasia in 106 patients (47%). We investigated patient lipid profiles by assessing total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TGs), apolipoprotein (Apo) A1 and B, lipoprotein (a) levels and ApoB/A1 ratio. Since age and body mass index affect the lipid profile, we performed propensity score matching to select 304 patients for final analysis and compared lipid profiles between the ON and OA groups. We also compared biomarkers between the ON subgroups and the OA group.

Results:
Overall, the ON group showed lower HDL-C (p < 0.001), higher TGs (p = 0.001) levels and higher ApoB/A1 ratio (p = 0.003). Idiopathic ON patients demonstrated lower HDL-C (p = 0.032), higher TGs (p = 0.016), ApoB (p = 0.024) levels and ApoB/A1 ratio (p = 0.008). The alcohol-associated ON subgroup showed lower HDL-C (p < 0.001), higher TGs (p = 0.010) levels and ApoB/A1 ratio (p = 0.030). Finally, the steroid-associated ON subgroup demonstrated lower HDL-C (p = 0.003), higher TGs (p = 0.039), lower TC (p = 0.022), LDL-C (p = 0.021), and ApoA1 (p = 0.004) levels.

Conclusions:
Higher TGs and lower HDL-C levels were associated with nontraumatic ON regardless of the etiology. Additionally, idiopathic ON was associated with higher ApoB levels and ApoB/A1 ratio. Alcohol-associated ON was related to higher ApoB/A1 ratio, and steroid-associated ON paired with decreased TC, LDL-C, and ApoA1 levels. Our findings may support future efforts for prevention and management of nontraumatic ON.

Level of Evidence:
Diagnostic Level III.
Core Decompression and Bone Marrow Aspiration Concentrate Grafting for Osteonecrosis of the Femoral Head
Authors: Hoogervorst Paul , Campbell Joshua C. , Scholz Natalie , Cheng Edward Y. 
Published: April 2022

Background:
Core decompression (CD) with bone marrow aspiration concentrate (BMAC) is a technique that may improve outcomes in osteonecrosis of the femoral head (ONFH). The primary aim of this study was to evaluate the radiographic progression free survival (PFS) of CD augmented with BMAC. Secondary aims were to determine the survivorship with conversion (CFS) to total hip arthroplasty (THA) as an endpoint, determine prognostic factors, and characterize the cellular quality of the BMAC.

Methods:
A retrospective cohort study of 61 femoral heads (40 patients) was performed. Patient demographics, comorbidities, BMI, smoking status, etiology, location and extent of ONFH were recorded. The primary endpoint was radiographic progression of ONFH and secondarily, conversion to THA. Additional aims were to determine predictive factors for progression and report the cellular characteristics of the BMAC. Data obtained were compared to the results of a prior randomized controlled trial comparing CD alone versus CD with polymethylmethacrylate cement (PMMA) augmentation.

Results:
Radiographic PFS of CD with BMAC at 2 and 5 years was 78.3% and 53.3%, respectively. The risk of progression was lower in the CD with BMAC group compared to CD alone (HR0.45, p = 0.03), however this difference no longer remained statistically significant on multivariate analysis. Conversion to total hip arthroplasty free survival (CFS) of CD with BMAC at both 2 and 5 years was 72.1% and 54.6%, respectively with no differences compared to the control groups (CD alone, CD and PMMA). The predictive factors for progression were obesity (BMI ≥ 30) and the extent of the disease as quantified by either percentage involvement, necrotic index or modified necrotic index.

Conclusions:
No differences in PFS or CFS between CD with BMAC compared to CD alone or CD with PMMA were identified. Independent statistically significant predictors of progression-free survival or conversion to THA are BMI ≥ 30 and the extent of ONFH. Further research with an adequately powered randomized controlled trial is needed.

Level of Evidence:
3
Deep Learning Accelerated Hydraulic-Mechanical Simulation with Prior Smoothness Constraints for Heterogeneous Petroleum Reservoirs
Authors: Wang Shihao , Zhang Yanbin , Wu Yu-Shu 
Published: April 2022

Summary
Coupled hydraulic-mechanical (HM) reservoir simulation requires tremendous efforts of development and is usually time-consuming. Consequently, the accurate yet fast simulation of poroelastic reservoirs is a challenge to traditional reservoir simulation methods. In this work, we aim to resolve this issue by replacing the geomechanical simulation module with a proxy stress predictor. We have developed a deep learning (DL)-based stress inference module to accelerate geomechanical simulation. The DL is based on convolutional neural network. We have constructed a 2D U-Net network, which takes the pressure, rock properties, and initial and boundary conditions as input and predicts the induced stress fields. We use the upper bound of the gradient of the stress field, which is from the a priori analysis of the mechanical governing equation, as a Lipschitz smoothness constraint. The model is trained with 80,000 pressure–stress pairs and demonstrates accuracy that is greater than 99%. We have augmented the trained network to a hydraulic reservoir simulator to conduct coupled HM simulation. Our results show that the proxy network effectively reduces the computational time of the mechanical module by more than 90% while still maintaining the accuracy of the physical simulator. The smoothness-constrained U-Net demonstrates significantly higher convergence rate and generalization capability. The novelty of this work is that it is arguably the first effort to combine a priori analysis of governing partial differential equations (PDE) with convolutional neural networks.
Volasertib as a monotherapy or in combination with azacitidine in patients with myelodysplastic syndrome, chronic myelomonocytic leukemia, or acute myeloid leukemia: summary of three phase I studies
Authors: Platzbecker Uwe , Chromik Joerg , Krönke Jan , Handa Hiroshi , Strickland Stephen , Miyazaki Yasushi , Wermke Martin , Sakamoto Wataru , Tachibana Yoshifumi , Taube Tillmann , Germing Ulrich 
Published: April 2022

Abstract
This report summarizes three phase I studies evaluating volasertib, a polo-like kinase inhibitor, plus azacitidine in adults with myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia, or acute myeloid leukemia. Patients received intravenous volasertib in 28-day cycles (dose-escalation schedules). In Part 1 of 1230.33 (Study 1; NCT01957644), patients received 250–350 mg volasertib on day (D)1 and D15; in Part 2, patients received different schedules [A, D1: 170 mg/m2; B, D7: 170 mg/m2; C, D1 and D7: 110 mg/m2]. In 1230.35 (Study 2; NCT02201329), patients received 200–300 mg volasertib on D1 and D15. In 1230.43 (Study 3; NCT02721875), patients received 110 mg/m2 volasertib on D1 and D8. All patients in Studies 1 and 2, and approximately half of the patients in Study 3, were scheduled to receive subcutaneous azacitidine 75 mg/m2 on D1–7. Overall, 22 patients were treated (17 with MDS; 12 previously untreated). Across Studies 1 and 2 (n = 21), the most common drug-related adverse events were hematological (thrombocytopenia [n = 11]; neutropenia [n = 8]). All dose-limiting toxicities were grade 4 thrombocytopenia. The only treated patient in Study 3 experienced 18 adverse events following volasertib monotherapy. Studies 1 and 2 showed preliminary activity (objective response rates: 25% and 40%). The safety of volasertib with azacitidine in patients with MDS was consistent with other volasertib studies. All studies were terminated prematurely following the discontinuation of volasertib for non-clinical reasons by Boehringer Ingelheim; however, safety information on volasertib plus azacitidine are of interest for future studies in other diseases.
Significant muscle loss despite high response rate during epidermal growth factor receptor tyrosine kinase inhibitors treatment for advanced lung adenocarcinoma
Authors: Nie Xin , Zou Ming-zhu , Hu Xue-qing , Liu Wei , Li Lin 
Published: April 2022

Abstract
Purpose This study aimed to evaluate skeletal muscle change during epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) treatment as well as its association with survival in advanced lung adenocarcinoma patients.Methods We retrospectively evaluated 72 EGFR-mutant advanced lung adenocarcinoma patients treated with first line icotinib or afatinib. Skeletal muscle was measured by the analysis of computed tomography (CT) obtained before and during EGFR-TKIs. The median time between two CT scans was 109 days (interquartile range, 91 to 123 days). Total cross-sectional skeletal muscle area and muscle CT value in third lumbar vertebra (L3) region was computed using OsiriX software. Sarcopenia was defined as skeletal muscle index<38.5 cm2/m2 for women and <52.4 cm2/m2 for men. Results The mean age (±standard deviation) at diagnosis was 64.5 (±12.0) years. At baseline,58.3% patients were diagnosed with sarcopenia. Sarcopenia was associated with advanced age (p<0.001), comorbidity (p=0.036) and lower body mass index (p<0.001). Although 54.2% patient achieved partial response, mean skeletal muscle area in L3 reduced 1.7cm2(95% confidence interval [CI]: -2.7 to -0.6; p= 0.003) for entire group at approximately 3 months of EGFR-TKIs treatment, corresponding to a reduction of whole-body muscle mass of 0.51kg (95%CI: -0.81 to -0.18). Although muscle status did not affect efficacy of EGFR-TKIs, muscle loss during treatment (HR 2.12, 95%CI: 1.12 to 4.03; p=0.021) instead of baseline sarcopenia was an independent prognostic factor for poor survival. Conclusions Patients had significant muscle loss during EGFR-TKIs. Further studies were warranted for maintain muscle mass during treatment.