bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spontaneous Lymphoma in a SMP30 Knock-Out C57BL/6 Mouse
Authors: Lee Seoung-Woo , Baek Su-Min , Lee Young-Jin , Park Jin-Kyu 
Published: December 2022

Abstract
70-weeks-old female C57BL6 senescence marker protein 30 knock out mice exhibited anorexia, lethargy and enlarged abdomen because of an intraperitoneal mass. On necropsy, the mouse revealed a large brown-whitish mass located on the mesentery. The mass also exhibited systemic metastasis and spread over in various organs. On microscopic findings, the neoplastic masses were mainly composed of neoplastic round cells characterized by severe anisokaryosis, narrow cytoplasm, round nuclei, prominent nucleoli, and numerous mitotic figures (13-15 in a 400X field). Consequently, the present case was diagnosed as a metastatic lymphoma arising from a mesenteric lymph node, the tumor spread to other organs such as the intestine, kidney and thoracic cavity. According to previous studies, SMP30 plays an important role in inhibiting cancer in both human and mouse. Taken together, it seems that the present case can be used as a valuable asset for evaluating the potential risks of SMP30 depletion in developing lymphoma.
A New Wooden Supply Chain Model for Inventory Management Considering Environmental Pollution: A Genetic algorithm
Authors: Babaeinesami Abdollah , Ghasemi Peiman , Chobar Adel Pourghader , Sasouli Mohammad Reza , Lajevardi Masoumeh 
Published: December 2022

Abstract
Nowadays, companies need to take responsibility for addressing growing markets and the growing expectations of their customers to survive in a highly competitive context that is progressing on a daily basis. Rapid economic changes and increasing competitive pressure in global markets have led companies to pay special attention to their supply chains. As a result, in this research, a mathematical model is proposed to minimize closed loop supply chain costs taking into account environmental effects. Thus, suppliers first send wood as raw materials from forests to factories. After processing the wood and turning it into products, the factories send the wood to retailers. The retailers then send the products to the customers. Finally, customers send returned products to recovery centers. After processing the products, the recovery centers send their products to the factories. The considered innovations include: designing a supply chain of wood products regarding environmental effects, customizing the genetic solution approach to solve the proposed model 3-Considering the flow of wood products and determining the amount of raw materials and products sent and received.
Content Analysing Work Performance of Lecturers in Southwestern Nigeria
Authors: Adesa Ademola , Oladejo Segilola 
Published: December 2022

Abstract
Lecturers in Nigerian universities, according to literature, are subjected to challenging workplace conditions that tends to inhibit their performance and subsequently, their ability to achieve the teaching, research and community development service functions of their job description. It, therefore, becomes pertinent that the work performance of lecturers be analysed to either support or negate existing literature on the subject matter. This study is qualitative in nature and data was gathered through in-depth interview schedule from nine universities across Southwestern Nigeria (three Federal universities, three State universities and three Private universities). Three face-to-face individual interviews were held with academic staff who were Heads of Department and/or Deans in each of the selected universities giving a total of 27 of such interviews.Data were analysed using content analysis. The study found out that there are hinderances surrounding the work performance of lecturers particularly in terms of efficiency, effectiveness and productivity due to challenging poor working conditions such as erratic power supply, increased workload, absence of certain office facilities and lack of research funds. This study thus supports existing literature.
Academic self-regulation and academic performance of humanities and social science students
Authors: Relleve Cesar Chester O. , Pangilinan Michael C. , Ronio Maricor N. 
Published: December 2022

Abstract
The goal of this research is to find out if the Academic Self-Regulation can predict the Academic Performance of Grade 11 students enrolled in the subject Disciplines and Ideas in the Applied Social Sciences by analyzing the Regression Model. In this study, the Quantitative-Descriptive method was used. The results revealed that: a) Identified Regulation is the highest while the Intrinsic Motivation is the lowest; b) there is a significant difference in the academic performance of the students, female students have higher grades compared to males; c) there is no significant difference in the self-regulation of the students; d) significant difference exists within the self-regulations so Post Hoc Analysis was employed; e) based on Bonferroni post host test there is no significant difference between Introjected Regulation and Intrinsic Motivation; f) the overall regression model is not statistically significant to predict the Academic Performance of the students.
Isolasi DNA pada Produk Otak-Otak Ikan Bandeng
Authors: Utaminingsih Sri , Utami Sofia Dyah , Sophian Alfi 
Published: December 2022

Latar belakang: Analisis mutu DNA hasil isolasi merupakan teknik analisis yang digunakan untuk mengetahui kualitas DNA hasil isolasi sehingga meminimalkan kegagalan proses amplifikasi dalam analisis molekuler. Tujuan: Tujuan dilakukan penelitian ini adalah untuk melihat mutu DNA hasil isolasi pada produk pangan olahan ikan berupa otak-otak ikan bandeng. Prosedur ekstraksi DNA mengikuti protokol ekstraksi manual kit yang digunakan. Analisis mutu DNA hasil isolasi diukur menggunakan nanophotometer, dimana analisis mutu berdasarkan nilai konsentrasi dan kemurnian DNA hasil isolasi. Analisis data dilakukan menggunakan uji rata-rata nilai konsentrasi dan kemurnian. Hasil: Berdasarkan hasil analisis mutu DNA diperoleh hasil konsentrasi DNA berada pada kisaran 9.6 – 18.5 dengan nilai rata-rata DNA hasil isolasi berada pada nilai 13.4 ng/µL, sedangkan nilai kemurnian yang dibaca pada panjang gelombang A260/A28 berada pada kisaran 1.64 – 1.87, dengan nilai rata-rata berada pada nilai 1.79. Simpulan: Sehingga dapat disimpulkan bahwa DNA hasil isolasi yang dilakukan pada sampel produk pangan olahan otak-otak ikan bandeng menunjukkan nilai konsentrasi dan kemurnian yang masuk dalam kategori hasil isolasi DNA yang baik.
Satisfaction of mahasantri in accessing Instagram
Authors: Luthfi Mohammad , Firmansyach Ade Bayu 
Published: December 2022

Indonesia has active social media users of 68.9% or 191.4 out of 277.7 million in 2022. Instagram is the second social media platform, with active users accounting for 84.8% of the population. The use of Instagram is certainly driven by certain motives that encourage people's attitudes and beliefs to access media as needed, and Instagram can provide satisfaction according to the needs of its audience. This study aims to examine the satisfaction of the Mahasantri University of Darussalam Gontor in accessing Instagram by taking 300 samples from 1,997 populations. The data were analysed using descriptive statistics to describe the findings referring to the Expectancy Value theory as a development of the Uses and Gratification theory with two variables, namely gratifications sought (GS) and gratification obtained (GO). Then a gap test was conducted between the mean scores of the GS and GO variables to determine the satisfaction of Darussalam Gontor University students in accessing Instagram social media. The results showed that Instagram could pleasure the Mahasantri University of Darussalam Gontor in building personal relationships, filling free time, getting entertainment, fulfilling knowledge needs, and solving problems. This study answers the phenomenon of using Instagram as the second most accessed social media platform by Indonesian people, especially among teenagers. This finding positively contributes to the University of Darussalam Gontor and educational institutions' management in using Instagram as a medium of socialisation and promotion. Also, as an effort for the government to improve social media literacy for the younger generation through various creative and educational content through Instagram.
Anodal Block in Evaluation of Nerve Conduction Changes in Anesthetized Rats: Preclinical Non-Randomized Experimental Study
Authors: Pokrovskiy V. M. , Ardelyan A. N. , Tashu B. S. , Arutyunyan N. A. , Sherbakov O. Y. , Pilipenko S. S. , Pocheshkhova D. A. 
Published: December 2022

Background. There is currently no gold standard for functional assessment of nerve regeneration. Different researchers use various methods to assess the functionality of the regenerated nerve directly and indirectly. Indirect methods have the advantage of being minimally invasive, and the benefit of direct methods is recording the signal directly in the nerve.Objectives. To identify significant parameters of neurogram changes in the sciatic nerve in an anaesthetized rat when the anode block is applied and to evaluate neurography as a method for functional assessment of nerve regeneration.Methods. A series of experiments was performed on 10 anaesthetized rats. A DC anode was placed on the exposed sciatic nerve, more proximal and more distal to the recording electrodes, and a common cathode in the form of a needle was introduced into one of the forelimbs. Needle nichrome electrodes were introduced into the nerve using a manipulator. An original neurogram and a neurogram against anode activation were recorded by closing the DC circuit of different voltages to block the afferent signal, efferent signal and afferent and efferent signals simultaneously.Results. When the anodal block of different voltages was applied to the afferent signal, efferent signal, and afferent and efferent signals simultaneously in all 10 experiments, the frequency-amplitude characteristics of the neurogram changed significantly as compared to the original neurogram. The amplitude of the neurogram increased considerably, while the frequency decreased, though not so dramatically. The changes in amplitude and frequency parameters were revealed to depend on the voltage value. In most cases, this relationship was directly proportional to the amplitude and inversely proportional to the frequency.Conclusion. Considering the nature of the dynamics of the neurogram when exposed to the anodal block, the most significant parameter of its change is the amplitude. Changes in nerve fibre composition during its regeneration after damage cause changes in afferent and efferent signals, which is likely to be displayed in the neurogram as compared to the initial state. Thus, the anodal block can be used as a model of nerve damage, and the analysis of the dynamics of neurogram parameters — as a method for functional assessment of nerve regeneration.
Intensive Care Outcomes and Differences Between Survivors and Deceased Patients in a Terminal Coma: A Retrospective Observational Study
Authors: Konareva T. I. , Malyshev Yu. P. , Golubtsov V. V. 
Published: December 2022

Background. Early prognosis for the outcome of a coma-induced critical condition is central to selecting an optimal tactic for patient management. This question remains insufficiently studied, thus justifying the task of identifying significant criteria for differences in terminal coma patients (stage III, irreversible) who died and those recovered to different levels of consciousness.Objectives. To analyze the intensive care outcomes for patients in a terminal coma and to establish differences between the initial state of patients who have died and those who have recovered to different levels of consciousness.Methods. A retrospective observational study was conducted on 210 patients aged 21 to 65 hospitalized in the Anesthesiology and Resuscitation Unit of Ochapovsky Regional Clinical Hospital No. 1 (Krasnodarsky Krai) with a diagnosis of terminal coma in the period from 2010 to 2015. The study did not include patients with pregnancy, histologically-confirmed malignancies, cardiovascular diseases (NYHA classes III-IV, according to the New York Heart Association Functional Classification), terminal liver cirrhosis and chronic kidney disease at the stage of hemodialysis. Depending on the critical condition outcome, the admitted patients were divided into groups: group 1 (n = 101) — patients with adverse outcomes; group 2 (n = 109) — patients with relatively favorable outcomes (recovery to a level of consciousness at score 4 and higher, according to The Glasgow Coma Scale). The condition was assessed with referring to available clinical data. Statistical processing of the obtained study results was carried out via nonparametric techniques using Microsoft Excel 10 (Microsoft, USA) and Statistica 6.0 (StatSoft, USA).Results. The mortality structure against the background of a terminal coma in the following diagnosis: polytrauma — 54%, hemorrhagic stroke — 56%, isolated traumatic brain injury — 37%, acute cerebrovascular accidents (ischemic type) — 33% and acute posthypoxic dyscirculatory encephalopathy — 11%. Intergroup differences between the deceased and survivors were obtained in the following parameters: age (older with unfavorable outcome); base deficit — by 52%; glucose — by 47.6%; troponin — by 47.1%; potassium — by 13.7% and daily diuresis — by 27.5%.Conclusion. The obtained results are likely to be used in a combination of clinical, instrumental and laboratory examinations in order to provide early detection of the risk group with an adverse outcome.
Diagnostic and Treatment Errors in Biliary Cystadenomas and Cystadenocarcinomas: Clinical Cases
Authors: Ayvazyan Kh. A. , Kuzminikh E. D. , Shevchenko T. V. , Stepanova Yu. A. , Zhavoronkova O. I. , Ionkin D. A. , Shirokov V. S. , Glotov A. V. , Gurmikov B. N. , Zhao A. V. 
Published: December 2022

Background. Biliary cystadenomas and cystadenocarcinomas are rare cystic tumors of the liver. Complicated differential diagnostics for simple cysts often leads to errors in surveillance of patients with these tumors. Cystadenoma and cystadenocarcinoma should be suspected upon detection of single or multilocular cystic neoplasms of the liver with septa and blood flow loci in the cyst wall, especially in middle-aged women. The localization of the tumor is critical. The most common localization is segment IV of the liver. Urgent intraoperative biopsy is required to determine the extent of surgery.Case description. Clinical observations with analysis of the examination and treatment data of two female patients aged 38 and 56 were presented. Both clinical observations illustrate the underestimation of the preoperative examination data that served as a ground for diagnosis of liver cysts with inadequate extent of surgery. In the first case, the resection was incomplete, and, as such, the biliary cystadenoma recurred in the resection area, the capsule of the neoplasm was ruptured and an encysted fluid collection was formed. In the second case, lack of histological examination of the excised neoplasm, due to confidence in its morphological verification as a cyst, resulted in cystadenoma recurrence in the resection zone with metastasis to the contralateral lobe of the liver.Conclusion. Hepatic cystadenomas and cystadenocarcinomas are often misdiagnosed as simple cysts. These tumors should be suspected in central localization of the tumor in the liver, especially in young women. The clinical and instrumental symptomatology and radiological semiotics of the disease require careful evaluation. The recurrence of a cystic lesion in the resection zone in a patient previously operated for a hepatic cyst serves as an additional signal for detecting biliary cystadenoma. Rational strategy for surgical management of cystic liver lesions should include hepatectomy within healthy tissues (both anatomical and atypical) with mandatory intraoperative ultrasound and urgent histological examinations.
Occipital condyle fracture caused by minor head trauma
Authors: Hayashi Seiya , Umakoshi Michiari , Yunoki Masatoshi , Hirashita Koji 
Published: December 2022

Background:
Occipital condyle fractures (OCF) are commonly identified in patients suffering from severe craniocerebral trauma. Here, we present a 57-year-old male whose computed tomography (CT)-documented atlanto-occipital dislocation (AOD), due to just minor trauma was successfully managed with bracing alone.

Case Description:
A 57-year-old male presented with the right upper neck pain following a motor vehicle accident. The screening cervical CT scan revealed a fracture of the right occipital condyle, while the subsequent dynamic X-rays showed no instability or AOD. The patient was treated with a hard cervical collar, and over the next 6 months, remained asymptomatic. The 6-month repeat craniocervical CT scan additionally confirmed spontaneous fusion at the fracture site.

Conclusion:
Patients who have sustained even mild craniocervical trauma may develop AOD attributed to an OCF. It is critical to screen these patients early with CT and X-ray studies so they can be successfully managed with bracing alone, and avoid the need for surgery to address the delayed onset of instability.
Primary midbrain germinoma relapse-free for 5 years: A case report
Authors: Oshima Akito , Kimura Toshikazu , Akabane Atsuya , Inoue Tomohiro 
Published: December 2022

Background:The biology and clinical course of intracranial germinomas differ as per their location of occurrence. Germinoma of the primary midbrain is particularly rare, and its clinical features, treatment strategies, and long-term prognosis remain uncertain.Case Description:A 39-year-old man who had been diagnosed with midbrain germinoma by open biopsy through the occipital transtentorial approach had undergone chemoradiotherapy and achieved 5 years with no recurrence.Conclusion:Germinomas should be considered as a differential diagnosis for adolescents and young adult men with mesencephalic tumors, and reliable sampling followed by chemoradiotherapy must be performed.
TEXTO DE DIVULGAÇÃO CIENTÍFICA: UMA POSSIBILIDADE PARA DISCUSSÃO DO CONTEÚDO POLÍMEROS NO ENSINO MÉDIO
Authors: Sousa Bárbara Lethicya Silva , Cantanhede Severina Coelho da Silva , Cantanhede Leonardo Baltazar , Sousa Diana Araujo de 
Published: December 2022

Os Textos de Divulgação Científica (TDC) divulgam a ciência de forma clara e acessível para o público em geral, permitindo a articulação dos saberes científicos com a sociedade em geral. Assim, propostas de inclusão de TDC no ambiente escolar têm se destacado como um caminho viável para atender diferentes necessidades de aprendizagem recorrentes na Educação Básica. Neste trabalho, investigamos o potencial do uso de TDC no Ensino Médio como um recurso didático para o ensino da Química. Para tanto, elaboramos e aplicamos uma estratégia didática pautada no uso do TDC da Revista Ciência Hoje, seção O Leitor Pergunta A sacola de amido pode ser uma solução menos danosa ao ambiente, do que as sacolas tradicionais? (Edição 305, julho/2013, nº. 53). A escolha do TDC foi orientada, considerando a relevância do assunto e a discussão da pergunta, como forma de facilitar o estudo do conteúdo de polímeros. A análise e a viabilidade da utilização dos TDC foram realizadas pelo uso de questionário no formato Likert, além de questões discursivas. O somatório dos índices positivos de análise apresentou valor próximo a 90%. Sob o ponto de vista pedagógico, o TDC possibilitou debates a partir da sistematização dos conhecimentos científicos associados à discussão do conteúdo polímeros, integrando problemáticas sociais, como a poluição ambiental, descarte, reciclagem, plásticos e lixo que estão presentes nas discussões do conteúdo polímeros, contribuindo para o exercício da cidadania dos estudantes, a partir de uma maior consciência ambiental sob a utilização de sacolas plásticas.
Is the Get-passive Really that Adversative?
Authors: Coto Villalibre Eduardo 
Published: December 2022

The characteristics commonly attributed to central get-passives in the relevant literature include the possibility of taking an overtly expressed agent by-phrase, a dynamic meaning conveyed by the lexical verb, an animate and human referent who is at the same time responsible for the action expressed in the clause, and an adversative semantic implication of the past participle. This paper focuses on one of the abovementioned features: the semantic implication of get-passives, that is, whether the event described in the clause is beneficial or favorable for the subject (get awarded, get elected, get promoted), adversative or unfavorable for the subject (get arrested, get killed, get shot), or semantically neutral (get printed, get sent, get written). Data collected from a corpus-based analysis of the spoken British English component and other spoken ESL components of the International Corpus of English (ICE) will be deployed to argue against those claims which define the get-passive as a predominantly negative or adversative construction in Present-Day English.
PERANCANGAN SISTEM INFORMASI MANAJEMEN KEPEGAWAIAN (SIMPEG) BERBASIS WEB PADA UNIVERSITAS NEGERI MAKASSAR
Authors: Bahar Muhammad Mahdinul , Nurwahid Muhammad Syahid , Putra Suhendhar Aji , Parenreng Jumadi Mabe , Wahid Abdul , Irmawati Irmawati 
Published: December 2022

Pada sektor pelayanan publik yang dilakukan oleh pemerintah telah mengalami perkembangan teknologi informasi dan komunikasi yaitu melalui elektronic government (e-government). Salah satu upaya subbagian tenaga kependidikan kepegawaian pada biro umum dan keuangan Univrsitas Negeri Makassar dalam mendukung e-government yaitu dengan melaksanakan pengembangan Sistem Informasi Manajemen Kepegawaian (SIMPEG). Seluruh kegiatan kepegawaian tidak jauh dari pengolahan data pegawai. Pada subbagian tenaga kependidikan kepegawaian pada biro umum dan keuangan Univrsitas Negeri Makassar proses pengolahan data masih menggunakan microsoft excel atau secara manual dalam memasukan data dan pencarian data, sehingga dalam pengolahan data butuh waktu yang lama dan tidak efisien dalam pengerjaannya. Tujuan dari pengembangan aplikasi ini untuk Optimalisasi Pelayanan Administrasi Kepegawaian Melalui Pembangunan Aplikasi Dokumen Digital Pada Subbagian Tenaga Kependidikan.
Pengembangan Aplikasi Sim-Lab Universitas Negeri Makassar
Authors: Agung Muhammad , Ismail Ismail 
Published: December 2022

Penelitian ini dilakukan untuk mengembangkan suatu aplikasi yang dapat digunakan dalam memanajemen penyewaan dan peminjaman laboratorium yang ada dalam lingkup Universitas Negeri Makassar (UNM). Tujuan penelitian ini: 1) aplikasi sistem informasi peminjaman atau penyewaan laboratorium yang terkomputerisasi sehingga pencatatan tidak akan dilakukan secara manual. 2) sebagai layanan system informasi manajemen pengolahan data laboratorium di Universitas Negeri Makassar. Hasil yang diperoleh pada penelitian ini adalah sebuah sistem sim lab yang memanajemen data laboratorium, penyewaan laboratorium dan peminjaman laboratorium Dirancang menggunakan pendekatan prototyping models dan telah diuji validasi fungsionalitas sistem berjalan dengan baikKata kunci: Laboratorium, UNM, peminjaman, Penyewaan, UPT TIK.