bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered Neuroanatomical Signatures of Patients With Treatment-Resistant Schizophrenia Compared to Patients With Early-Stage Schizophrenia and Healthy Controls
Authors: Liu Congcong , Kim Woo-Sung , Shen Jie , Tsogt Uyanga , Kang Nam-In , Lee Keon-Hak , Chung Young-Chul 
Published: May 2022

BackgroundThe relationship between brain structural changes and cognitive dysfunction in schizophrenia is strong. However, few studies have investigated both neuroanatomical abnormalities and cognitive dysfunction in treatment-resistant schizophrenia (TRS). We examined neuroanatomical markers and cognitive function between patients with TRS or early-stage schizophrenia (ES-S) and healthy controls (HCs). Relationships between neuroanatomical markers and cognitive function in the patient groups were also investigated.MethodsA total of 46 and 45 patients with TRS and ES-S and 61 HCs underwent structural magnetic resonance imaging (MRI) brain scanning and comprehensive cognitive tests. MRI scans were analyzed using the FreeSurfer to investigate differences in cortical surface area (CSA), cortical thickness (CT), cortical volume (CV), and subcortical volume (SCV) among the groups. Four cognitive domains (attention, verbal memory, executive function, and language) were assessed. Comparisons of neuroanatomical and cognitive function results among the three groups were performed.ResultsA widespread reduction in CT was observed in patients with TRS compared to HCs, but differences in cortical thinning between TRS and ES-S patients were mainly limited to the inferior frontal gyrus and insula. Several subcortical structures (accumbens, amygdala, hippocampus, putamen, thalamus and ventricles) were significantly altered in TRS patients compared to both ES-S patients and HCs. Performance in the verbal memory domain was significantly worse in TRS patients compared to ES-S patients. A positive relationship between the thickness of the left middle temporal gyrus and the composite score for language was identified in patients with ES-S.ConclusionsOur findings suggest significant cognitive impairment and reductions in CT and SCV in individuals with TRS compared to those with ES-S and HCs. These abnormalities could act as biomarkers for earlier identification of TRS.
Application of Smartphone Otoscope in Telemedicine in Rural Medical Consortium in Eastern China in the COVID-19 Era
Authors: Meng Xiangming , Dai Zhiyong , Wang Ying , Hua Xiang , Gu Xiaobo , Guo Jianxun , Wang Yangyang , Hang Chao , Jiang Yuting 
Published: May 2022

PurposeThis study aimed to evaluate the effectiveness of smartphone otoscope telemedicine in the rural medical consortium in East China in the COVID-19 era.MethodsThis prospective study was conducted within a rural medical consortium that provides health care services by integrating medical resources in the same area. When a patient visited primary health care (PHC) for ear diseases, the PHC provider used a smartphone otoscope to examine the patient's external ear canal and eardrum, and then sent photos or videos of the patient's ear to the otolaryngologist at the lead hospital via WeChat group. The otolaryngologist provided remote diagnosis and management recommendations to the PHC provider. The following data were recorded: age and gender, outpatient diagnosis, disease duration, sides, duration of treatment, telemedicine visits, treatment outcomes, patient satisfaction, and PHC providers' self-evaluation score.ResultsA total of 83 patients were included in the study, including 43 males and 40 females, with a mean age of 44.6 ± 19.7 years (range 3–83 years). The duration of treatment for these patients was 14.0 (7,14) days. PHC visits were 2.2 ± 1.1 times (range: 1–7 times). Telemedicine visits ranged from 1 to 5, with a mean of 1.8 ± 0.9. Among of patients, 62 (74.7%) were cured, 21 (25.3%) improved, and 0 (0%) were ineffective. Sixty-five patients (78.3%) were very satisfied, 16 (19.3%) patients were somewhat satisfied, and two patients (2.4%) were dissatisfied. Based on the self-reported helpfulness, the primary health care providers assessed telemedicine as very helpful (n = 63, 75.9%), helpful (n = 20, 24.1%), and unhelpful (n = 0, 0%).ConclusionsSmartphone otoscope telemedicine in the medical consortium can effectively improve the ability of rural PHC providers to diagnose and treat ear diseases, save time and costs for patients, and improve patient satisfaction.
Structural Equation Model Analysis of HIV/AIDS Knowledge, Attitude, and Sex Education Among Freshmen in Jiangsu, China
Authors: Tu Fulai , Yang Ruizhe , Li Rui , Du Guoping , Liu Yangyang , Li Wei , Wei Pingmin 
Published: May 2022

BackgroundThe study of acquired immunodeficiency syndrome (AIDS) related knowledge, attitude, and sex education status of Jiangsu freshmen was conducted, which can provide data support directionally for the prevention work of HIV/AIDS among this population.MethodsMale students (4,006) and female students (4,279) were selected from 20 universities or colleges in the Jiangsu province. The knowledge, attitudes, and sex education of freshmen were conducted with an online questionnaire. The log-binomial regression model was used to analyze the influencing factors of HIV/AIDS knowledge. In addition, a structural equation model was used to analyze students' health needs that affect knowledge awareness and knowledge mastery.ResultsThe overall awareness rate of AIDS knowledge was 87.4%. The students in undergraduate colleges (OR = 2.523, 95% CI=2.223~2.864) and independent colleges (OR = 1.389, 95%CI = 1.172~1.646) were more likely to have a higher awareness compared with the students in junior colleges. In this study, 2,011 freshmen approved of premarital behavior, 4,921 freshmen insisted on using condoms when having sex, and 8,138 freshmen were willing to take HIV antibody test when they suspected they were infected. In total, 4,703 freshmen believed that sexual health education was necessary for colleges and universities, and most of them (57.2%) hoped that sex education in schools should be improved. The direct effect of sex education on knowledge awareness and attitude is 0.15 and 0.58. The mediation effect test found that the pass ability knowledge path of sex education indirectly affected sexual attitudes (0.05).ConclusionThe awareness rate of HIV/AIDS among Jiangsu freshmen has not reached the national standard. Health education has a significant positive effect on knowledge awareness and attitude; however, students' needs in terms of time, place, and degree of sex education have not been met in time. It is necessary to strengthen the HIV/AIDS health education of college students in multiple ways.
Intelligent Recognition and Analysis of Negative Emotions of Undergraduates Under COVID-19
Authors: Zhang Weifeng 
Published: May 2022

BackgroundThe outbreak and spread of COVID-19 has brought a tremendous impact on undergraduates' study and life, and also caused anxiety, depression, fear and loneliness among undergraduates. If these individual negative emotions are not timely guided and treated, it is easy to cause the amplification of social negative emotions, resulting in individual and collective irrational behavior, and ultimately destroy social stability and trust foundation. Therefore, how to strengthen the analysis and guidance of negative emotions of undergraduates has become an important issue to be urgently solved in the training of undergraduates.MethodThis paper presents a weight and structure double-determination method. Based on this method, a Radial Basis Function Neural Networks (RBFNN) classifier is constructed for recognizing negative emotions of undergraduates. After classifying the input psychological crisis intervention scale samples by the RBFNN classifier, recognition of negative emotions for undergraduates are divided into normal, mild depression, moderate depression and severe depression.ExperimentsAfterwards, we analyze negative emotions of undergraduates and give some psychological adjustment strategies. In addition, the experiment results demonstrate that the proposed method has a good performance in terms of classification accuracy, classification time and recognition rate of negative emotions among undergraduates.
Role of Foreign-Born Status on Suicide Mortality in Spain Between 2000 and 2019: An Age-Period-Cohort Analysis
Authors: Martínez-Alés Gonzalo , Gimbrone Catherine , Rutherford Caroline , Keyes Katherine , López-Cuadrado Teresa 
Published: May 2022

Objectives: To examine recent age-period-cohort effects on suicide among foreign-born individuals, a particularly vulnerable sociodemographic group in Spain.Methods: Using 2000–2019 mortality data from Spain’s National Institute of Statistics, we estimated age-period-cohort effects on suicide mortality, stratified by foreign-born status (native- vs. foreign-born) and, among the foreign-born, by Spanish citizenship status, a proxy for greater socioeconomic stability.Results: Annual suicide mortality rates were lower among foreign- than native-born individuals. There was heterogeneity in age-period-cohort effects between study groups. After 2010, suicide mortality increased markedly among the foreign-born—especially for female cohorts born around 1950, and slightly among native-born women—especially among female cohorts born after the 1960s. Among native-born men, suicide increased linearly with age and remained stable over time. Increases in suicide among the foreign-born were driven by increases among individuals without Spanish citizenship—especially among cohorts born after 1975.Conclusion: After 2010, suicide in Spain increased markedly among foreign-born individuals and slightly among native-born women, suggesting an association between the downstream effects of the 2008 economic recession and increases in suicide mortality among socioeconomically vulnerable populations.
The Cytoskeletal Protein Zyxin Inhibits Retinoic Acid Signaling by Destabilizing the Maternal mRNA of the RXRγ Nuclear Receptor
Authors: Parshina Elena A. , Orlov Eugeny E. , Zaraisky Andrey G. , Martynova Natalia Y. 
Published: May 2022

Zyxin is an LIM-domain-containing protein that regulates the assembly of F-actin filaments in cell contacts. Additionally, as a result of mechanical stress, Zyxin can enter nuclei and regulate gene expression. Previously, we found that Zyxin could affect mRNA stability of the maternally derived stemness factors of Pou5f3 family in Xenopus laevis embryos through binding to Y-box factor1. In the present work, we demonstrate that Zyxin can also affect mRNA stability of the maternally derived retinoid receptor Rxrγ through the same mechanism. Moreover, we confirmed the functional link between Zyxin and Rxrγ-dependent gene expression. As a result, Zyxin appears to play an essential role in the regulation of the retinoic acid signal pathway during early embryonic development. Besides, our research indicates that the mechanism based on the mRNA destabilization by Zyxin may take part in the control of the expression of a fairly wide range of maternal genes.
SCIENTIFIC EDUCATION AS THE BASIS FOR INNOVATIVE COMPETENCE FORMATION IN THE CONDITIONS OF DIGITAL TRANSFORMATION OF THE SOCIETY
Authors: Моисеенко Н. А. , Темирова А. Б. 
Published: May 2022

В статье обосновано понятие и необходимость внедрения научного образования в средней школе в условиях цифровой трансформации образования, представлен обзор инновационных методик обучения, которые могут эффективно применяться для распространения научного мышления на более широкий перечень учебных предметов и формирования STEAM и инновационной компетентности как ключевых компетентностей учащихся. Автором исследованы теоретические основы научного образования. Перечислены знания, навыки и деятельности, входящие в STEAM и инновационную компетентность. Доказано, что для их формирования целесообразно целенаправленно использовать в образовательном процессе метод учебных проектов, проблемное обучение и опытно-познавательный метод. В статье описаны особенности этих инновационных педагогических технологий при внедрении научного образования в средней школе на основе использования современных цифровых технологий и инструментов.
The article substantiates the concept and the need for the introduction of science education in secondary schools in the context of digital transformation of education, provides an overview of innovative teaching methods that can be effectively used to spread scientific thinking to a wider range of academic subjects and the formation of scientific and innovative competence as the key competencies of students. The author studies the theoretical foundations of scientific education. The knowledge, skills, and activities included in STEAM and innovation competence are listed. It is proved that for their formation it is advisable to purposefully use the method of educational projects, problem-based learning and the experimental- cognitive method in the educational process. The article describes the features of these innovative pedagogical technologies in the implementation of scientific education in secondary schools based on the use of modern digital technologies and tools.
INNOVATIVE EDUCATIONAL ENVIRONMENT AS A FACTOR OF PERSONAL SELF-REALIZATION
Authors: Базаева Ф. У. 
Published: May 2022

Образование - основная общественная сфера. Продуктивное функционирование этой сферы, ее модернизация - это залог развития остальных общественных сфер и будущего страны в целом. Эффективное внедрение современных цифровых технологий, электронного обучения, сетевых и дистанционных технологий обучения как составляющих инновационных технологий является существенным резервом повышения качества и доступности образования, а также выступает как фактор развития и самореализации личности, участвующей в ее процессах. Главная цель инноваций в образовательной среде - обеспечить условия для самореализации личности и потребностей человека, создать такую инновационную образовательную среду, которая способствовала бы самоутверждению личности в различных сферах творческой деятельности. Цель данного исследования - проанализировать инновационную образовательную среду как фактор самореализации личности.
Education is the main public sphere. The productive functioning of this sphere, its modernization is the key to the development of other public spheres and the future of the country as a whole.Effective implementation of modern digital technologies, e-learning, network and distance learning technologies as components of innovative technologies is an essential reserve for improving the quality and accessibility of education, and also acts as a factor of development and self-realization of the individual involved in its processes.The main goal of innovation in the educational environment is to provide conditions for self-realization of the individual and human needs, to create an innovative educational environment that would promote self-affirmation of the individual in various fields of creative activity.The purpose of this study is to analyze the innovative educational environment as a factor of personal self-realization.
KEY CONDITIONS FOR PREPARATION STAFF OF THE DIGITAL ECONOMY
Authors: Барзаева М. А. 
Published: May 2022

Вызовы современной экономики преобразовывают процессы, протекающие на рынке труда в условиях цифровизации. Важнейшим компонентом подобных преобразований является реализация поставленных задач в национальных проектах. Трансформационные преобразования затрагивают и процесс образования, формирование новых компетенций и навыков, способных построить новое цифровое общество и необходимость корректировки государственных программ и реализации национальных проектов, являющихся безусловными для выполнения. Обновление рабочих мест и интересные (востребованные) профессии в цифровой экономике уже сегодня формируют поведение работодателей на рынке труда и определение необходимых компетенций кадров. Актуальность данной статьи состоит в том, что современные тенденции развития цифровой экономики определяют характер и поведенческие факторы нового, формирующегося рынка труда, который заслуживает пристального изучения и внимания всех его участников.
The challenges of the digital economy are transforming the processes taking place in the labor market in the context of digitalization. The most important components of such transformations are the implementation of the tasks set in national projects.Transformational transformations also affect the processof education, the formation of new competencies and skills that can build a new digital society.The problems of transformational changes also affect the need to adjust government programs and implement national projects that are unconditional for implementation.The renewal of jobs and interesting (demanded) professions in the digital economy are already shaping the behavior of employers in the labor market and determining the necessary competencies of personnel.
OPTIMASI PRODUK MESIN PRESS PENCETAK BRIKET ARANG SEKAM PADI
Authors: Cholis Nur 
Published: May 2022

Rice husk is a rice-covering skin in which the rice husk will separate and become waste. Due to the continued abundant rice production, the amount of rice husk waste will also increase and not be processed so that it will accumulate to become garbage and increasingly damage the environment. In choosing this, take steps to improve the quality of the briquette press pressing machine using rice husk charcoal dough from a previously made machine. The purpose of this return is to produce a press machine for printing rice husk charcoal briquettes capable of printing rice husk charcoal up to 100kg / hour.
The machine uses a hydraulic jack to lift the thrusters to press briquettes. The hydraulic jack is driven by a motor with a power of 0.4 HP. The jack is placed under the prop on the thrust which is connected to the engine frame which has dimensions of 770 x 455 x 240 mm. This machine is made with an estimated price of Rp3,024,500.
Key words: rice husk, waste, briquettes, hydraulic jack
PERANCANGAN JARINGAN KOMUNIKASI SISTEM INFORMASI DAN ADMINISTRASI BRIMOB (SIAB) BERBASIS SERAT OPTIK
Authors: . Ariman , Iklil Mochamad 
Published: May 2022

Markas Komando Brimob uses optical fiber as a transmission media in the design of the Sistem Informasi dan Administrasi Brimob (SIAB) communication network. Optical fiber has a large transmission capacity, therefore fiber optic networks are implemented on network of SIAB. This facility includes withdrawal of fiber optic cable from Mako Brimob to seven points, namely Pool Mako, Mako Gegana, Pool Bengkel Gegana, Detasemen Gegana, Pool KBR, Pool Pelopor, and Danpas Pelopor.
The design of the SIAB network is adjusted to the needs of the Mako Brimob such as: 10-10 of BER, 100 Mbps of data speed, and 1310 nm of wavelength. The optical equipment used were single fiber optic tube loosen mode, PIN photodiode light detector, optical laser diode, and SC connector. From the power link analysis, the maximum distance without using an optical amplifier was 491.9 km. Then, the maximum speed was 896 Mbps measured using rise time budget.
Keywords: Power link budget, Rise time budget
ANALISA PROTEKSI OVER CURRENT RELAY (OCR) DAN GROUND FAULT RELAY (GFR) PADA TRANSFORMATOR DAYA GARDU INDUK
Authors: Multi Abdul , Addaus Thufail 
Published: May 2022

ABSTRACT
In the electric power distribution system, the power transformer is an equipment plays an important role in a substation. In a distribution system, a fault cannot be predicted. This fault can be in the form of a 3-phase, 2-phase, or 1-phase short-circuit fault to ground. In order to prevent this, a good and reliable protective equipment is needed, one of which is the Over Current Relay (OCR) and Ground Fault Relay (GFR) which are used as backup protection for power transformers. The work principle of the OCR is to detect the presence of a short-circuit current between phases and the work principle of the GFR is to detect a short-circuit current from the phase to ground, the results of the analysis carried out describe when the fault current exceeds the predetermined setting value then Over Current relay and Ground fault Relay takes instantaneous decisions or by slowing down the opening of the PMT in the event of a disturbance. After doing the calculations, for the setting current (OCR) on the 150 kV side, 277.2 A was obtained with the TMS (OCR) time setting of 0.31 and for the setting current (GFR) on the 150 kV side, 35.22 A was obtained with the TMS time setting ( GFR) is 0.44. For the setting current (OCR) on the 20 kV side, 2,078.4 A is obtained with the TMS time setting (OCR) of 0.23 and for the setting current (GFR) on the 20 kV side, 96.07 A is obtained with the TMS time setting (GFR) namely 0.3.
Keywords: Transformer, Over Current Relay, Ground Fault Relay, OCR, GFR
PENGARUH PEMBERIAN TEKNIK RELAKSASI OTOT PROGRESIF TERHADAP TINGKAT KECEMASAN PASIEN KEMOTERAPI
Authors: Saluy Priscillia Merylin , Tahir Puteri Irtha Ariani , Purnawinadi I Gede 
Published: May 2022

Peningkatan kecemasan dapat terjadi pada pasien dalam proses kemoterapi. Teknik relaksasi otot progresif adalah teknik relaksasi otot dalam memusatkan perhatian pada suatu aktivitas otot dengan mengidentifikasi otot yang tegang kemudian menurunkan ketegangan sehingga mendapatkan perasaan relaks dan menurunkan kecemasan. Tujuan penelitian ini adalah mengetahui apakah ada pengaruh dalam pemberian teknik relaksasi otot progresif terhadap tingkat kecemasan pasien setelah menjalani kemoterapi di RSUP Prof. Dr.R.D Kandou Manado. Metode penelitian ini adalah Pre-eksperimental dengan rancangan one group pre–post test. Hasil penelitian ini adalah menunjukkan ada pengaruhpemberian teknik relaksasi otot progresif terhadap tingkat kecemasan pasien kemoterapidengan p value 0.000< 0.05, tidak ada pengaruh pemberian teknik relaksasi otot progresif terhadap tingkat kecemasan pasien kemoterapibila usia diikutsertakan dengan p value 0.676 > 0.05, tidak ada pengaruh pemberian teknik relaksasi otot progresif terhadap tingkat kecemasan pasien kemoterapi bila pendidikan diikutsertakan dengan p value 0.450 > 0.05. Pemberian teknik relaksasi otot dapat dilakukan kepada pasien yang menjalani kemoterapi untuk menurunkan kecemasan pasien.
Kata Kunci: Teknik Relaksasi Otot Progresif, Kecemasan, Kemoterapi
HUBUNGAN PENGETAHUAN PASANGAN USIA SUBUR TENTANG METODE KONTRASEPSI DENGAN PEMAKAIAN KONTRASEPSI
Authors: Shintya Lea Andy , Monde Firginia Miranda 
Published: May 2022

Kontrasepsi merupakan suatu metode yang digunakan untuk mecegah kehamilan dengan menggunakan obat-obatan atau alat alat, yang terdiri dari kontrasepsi yang mengandung hormonal dan non hormonal, bersifat sementara dan permanen. Pemilihan kontrasepsi dapat dipengaruhi oleh pengetahuan tentang metode kontrasepsi dan pemakaian kontrasepsi. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan pasangan usia subur tentang metode kontrasepsi dengan pemakaian kontrasepsi di desa Pinasungkulan Utara. Metode penelitian menggunakan desain penelitian deskriptif korelasi dengan pendekatan cross sectional. Teknik pengambilan sampel menggunakan consecuttive sampling dengan jumlah sampel sebanyak 74 responden. Hasil penelitian, terdapat hubungan yang signifikan antara pengetahuan PUS tentang metode kontrasepsi dengan pemakaian kontrasepsi di Desa Pinasungkulan Utara yaitu p value 0,000 < 0,05 dan nilai contingency coefficient 0,695 yang artinya pengetahuan tentang metode kontrasepsi dengan pemakaian kontrasepsi mempunyai hubungan yang kuat dengan arah positif. Rekomendasi untuk peneliti selanjutnya dapat meneliti faktor-faktor lain yang mempengaruhi pemilihan jenis kontrasepsi pada PUS, seperti sosial ekonomi, pendidikan, dukungan suami/istri, umur, paritas, serta melakukan penelitian ditempat lain dengan jumlah sampel yang lebih besar.

Kata Kunci: pasangan usia subur, pemakaian kontrasepsi, pengetahuan