bluuebunny/crossref_metadata_2025_split huggingface dataset:
Grain Boundary Complexions Enable a Simultaneous Optimization of Electron and Phonon Transport Leading to High‐Performance GeTe Thermoelectric Devices
Authors: Zhang Chaohua , Yan Gan , Wang Yibo , Wu Xuelian , Hu Lipeng , Liu Fusheng , Ao Weiqin , Cojocaru‐Mirédin Oana , Wuttig Matthias , Snyder G. Jeffrey , Yu Yuan 
Published: November 2022

AbstractGrain boundaries (GBs) form ubiquitous microstructures in polycrystalline materials which play a significant role in tuning the thermoelectric figure of merit (ZT). However, it is still unknown which types of GB features are beneficial for thermoelectrics due to the challenge of correlating complex GB microstructures with transport properties. Here, it is demonstrated that GB complexions formed by Ga segregation in GeTe‐based alloys can optimize electron and phonon transport simultaneously. The Ga‐rich complexions increase the power factor by reducing the GB resistivity with slightly improved Seebeck coefficients. Simultaneously, they lower the lattice thermal conductivity by strengthening the phonon scattering. In contrast, Ga2Te3 precipitates at GBs act as barriers to scatter both phonons and electrons and are thus unable to improve ZT. Tailoring GBs combined with the beneficial alloying effects of Sb and Pb enables a peak ZT of ≈2.1 at 773 K and an average ZT of 1.3 within 300–723 K for Ge0.78Ga0.01Pb0.1Sb0.07Te. The corresponding thermoelectric device fabricated using 18‐pair p‐n legs shows a power density of 1.29 W cm−2 at a temperature difference of 476 K. This work indicates that GB complexions can be a facile way to optimize electron and phonon transport, further advancing thermoelectric materials.
Cracking‐Controlled Slurry Coating of Mosaic Electrode for Flexible and High‐Performance Lithium–Sulfur Battery
Authors: Luo Yufeng , Wang Lei , Wei Zhenyao , Huang Qiyao , Deng Yonghong , Zheng Zijian 
Published: November 2022

AbstractThe realization of high‐performance thick S cathodes is a critical step to achieve high energy density lithium–sulfur (Li–S) batteries. However, it normally requires a complicated and time‐consuming fabrication processes to obtain high‐performance S cathodes with high mass loading. On the other hand, thick S cathodes fabricated with high‐speed slurry coating method show poor flexibility, capacity, and cycle life due to unpredictable electrode cracking. Herein, an industrial‐speed cracking‐controlled slurry coating method to generate mosaic‐like cracks in the S cathode is developed, which provides vertical channels to facilitate the rapid diffusion of electrolyte, adequate space to accommodate the volume expansion during cycling, and strain‐releasing structure to achieve high flexibility. With this simple method, thick Mosaic‐S cathodes (9 mAh cm−2) provide outstanding energy density, long cycle life, and outstanding flexibility under dynamic bending. This work paves the way for scalable fabrication of high‐performance S cathodes in the near future.
Clinical implications and optimal extent of lymphadenectomy for intrahepatic cholangiocarcinoma: A multicenter analysis of the therapeutic index
Authors: Umeda Yuzo , Takagi Kosei , Matsuda Tatsuo , Fuji Tomokazu , Kojima Toru , Satoh Daisuke , Hioki Masayoshi , Endo Yoshikatsu , Inagaki Masaru , Oishi Masahiro , Yagi Takahito , Fujiwara Toshiyoshi 
Published: November 2022

AbstractAimsLymph node metastases (LNM) are associated with lethal prognosis in intrahepatic cholangiocarcinoma (ICC). Lymphadenectomy is crucial for accurate staging and hopes of possible oncological treatment. However, the therapeutic implications and optimal extent of lymphadenectomy remain contentious.MethodsTo clarify the prognostic value and optimal extent of lymphadenectomy, the therapeutic index (TI) for each lymph node was analyzed for 279 cases that had undergone lymphadenectomy in a multi‐institutional database. Tumor localization was divided into hilar lesions (n = 130), right peripheral lesions (n = 60), and left peripheral lesions (n = 89). In addition, the lymph node station was classified as Level 1 (LV1: hepatoduodenal ligament node), Level 2 (LV2: postpancreatic or common hepatic artery nodes), or Level 3 (LV3: gastrocardiac, left gastric artery, or celiac artery nodes).ResultsLymph node metastases were confirmed in 109 patients (39%). Five‐y survival rates were 45.3% for N0 disease, 27.1% for LV1‐LNM, 22.9% for LV2‐LNM, and 7.3% for LV3‐LNM (P < 0.001). LV3‐LNM were the most frequent and earliest recurrence outcome, including multisite recurrence, followed by LV2, LV1, and N0 disease. The 5‐year TI (5year‐TI) for lymphadenectomy was 7.2 for LV1, 5.5 for LV2, and 1.9 for LV3. Regarding tumor location, hilar lesions showed 5‐year TI >5.0 in LV1 and LV2, whereas bilateral peripheral lesions showed 5‐year TI > 5.0 in LV1.ConclusionThe implications and extent of lymphadenectomy for ICC appear to rely on tumor location. In the peripheral type, the benefit of lymphadenectomy would be limited and dissection beyond LV1 should be avoided, while in the hilar type, lymphadenectomy up to LV2 could be recommended.
Mechanical, thermal, tribological, and flammability properties of polybutylene terephthalate composites: Comparing the effects of synthetic wollastonite nanofibers, natural wollastonite, and graphene oxide
Authors: Chan Jia Xin , Wong Joon Fatt , Hassan Azman , Othman Norhayani , Abd Razak Jeefferie , Nirmal Umar , Hashim Shahrir , Ching Yern Chee , Yunos Muhamad Zaini , Yahaya Ridwan , Gunathilake T. M. Sampath U. 
Published: November 2022

AbstractPolybutylene terephthalate (PBT) composites were prepared with 1.0 phr synthetic wollastonite nanofibers (SWN), natural wollastonite (NW) and graphene oxide (GO) to study the effect of different fillers on mechanical, thermal, tribological, and flammability properties. The properties of PBT composites are related to the size, structure, and interfacial adhesion of the fillers in PBT matrix. PBT/SWN demonstrated the highest tensile strength and Young's modulus (6% and 9% increment), followed by PBT/NW (1.3% and 7% increment) and PBT/GO (2% decrement and 4% increment). PBT/SWN gave the highest degradation temperature (409°C), followed by PBT/GO (404.7°C). The maximum enhancement in wear resistance (73%) by PBT/SWN and anti‐friction performance (26%) by PBT/GO evinced the excellent load‐bearing ability of SWN and the great lubricating effect of GO. PBT/NW had the lowest peak heat release rate, smoke, and carbon dioxide production rate. This study shows that PBT composites have great potential in different automotive applications.
A comprehensive assessment of lymphocyte subsets, their prognostic significance, and changes after first‐line therapy administration in patients with chronic lymphocytic leukemia
Authors: Vodárek Pavel , Écsiová Dominika , Řezáčová Vladimíra , Souček Ondřej , Šimkovič Martin , Vokurková Doris , Belada David , Žák Pavel , Smolej Lukáš 
Published: November 2022

AbstractBackgroundIn chronic lymphocytic leukemia (CLL), changes in the peripheral blood lymphocyte subsets play an important role in disease progression and infectious complications. The impact of chemoimmunotherapy (CIT) on these changes has not been extensively studiedMethodsWe used multi‐color flow cytometry, to prospectively measure absolute and relative numbers of CD4+ and CD8+ T‐cells and their subsets in 45 patients with indolent untreated CLL, 86 patients indicated for first‐line treatment, and 34 healthy controls. In 55 patients, we analyzed the impact of CITResultsCLL patients had a significant increase in most cell populations in comparison to controls. Progression of CLL was characterized by significantly elevated counts with the exception of a lower percentage of naïve T‐cells. After treatment, the percentage of naïve T‐cells further decreased at the expense of effector memory T‐cells (TEM). In patients with indolent CLL, higher percentages of naïve CD4+ (p = 0.0026) and naïve CD8+ (p = 0.023) T‐cells were associated with a longer time to first treatment (TTFT). The elevation of CD4+ central memory T‐cells (TCM) (p = 0.27) and TEM (p = 0.003) counts and a higher percentage of CD4+ TEM (p = 0.0047), were linked with shorter TTFT. In treated patients, increased regulatory T‐cells count was associated with shorter time to next treatment (TTNT) (p = 0.042), while higher CD4+ TCM count with shorter TTNT (p = 0.035) and shorter overall survival (p = 0.041).ConclusionOur results indicate that naïve cell depletion and CD4+ TCM and TEM increases are detrimental to CLL patients' prognosis.
Synthesis of Palladium‐Catalysed C−C Bond Forming 5‐Chloro Quinolines via Suzuki‐Miyaura Coupling; Anti‐Pancreatic Cancer Screening on PANC‐1 Cell Lines
Authors: Rahman Abdul , Ningegowda Nippu Belur , Siddappa Manjunatha Kammathalli , Pargi Meghana , Kumaraswamy Honnenahally Malleshappa , Satyanarayan Nayak Devappa , Achur Rajeshwara 
Published: November 2022

AbstractPancreatic cancer is the most severe among other cancers due to its late detection and less chance of survivability. Heterocycles are proven ring systems in the treatment of various cancers and this is due to the presence of two biodynamic molecules combined, which have a greater synergistic efficacy in many anticancer drugs. Quinoline and pyridine ring systems are brought together to obtain greater potency and this is achieved by coupling both using Pd‐catalyst, and in the present investigation, Suzuki‐Miyaura coupling (SMC) reactions are adopted to generate potent molecular entities. Pancreatic cancer is difficult to treat due to overexpression of the VEGFR2 protein. VEGFR2 is targeted to design the molecules of quinoline‐coupled pyridine moieties and is docked to evaluate the protein‐ligand interaction at the binding site. The binding affinity of conjugates revealed the potency and capability of ligands to inhibit the VEGFR2 pathway. The in‐silico ADMET properties determined their inherent pharmacokinetic feasibility. The synthesized conjugates have been evaluated by MTT assay against the human pancreatic cancer cell lines (PANC‐1). Among the series, compounds 5d, 5e, and 5h exhibited a greater inhibitory activity against the cell lines with an IC50 value of 82.32±1.38, 54.74±1.18 and 80.35±1.68 μM. In the present exploration, 5e exhibited greater inhibitory activity and it could be a promising lead for the development of new chemotherapeutics against pancreatic cancer.
Chemical Constituents of the Deep‐Sea‐Derived Fungus Cladosporium oxysporum 170103 and Their Antibacterial Effects
Authors: Xie Ming‐Min , Jiang Jia‐Yang , Zou Zheng‐Biao , Xu Lin , Zhang Yong , Wang Chao‐Feng , Liu Cheng‐Bin , Yan Qing‐Xiang , Liu Zhu , Yang Xian‐Wen 
Published: November 2022

AbstractThe Cladosporium fungi, one of the largest genera of dematiaceous hyphomycetes, could produce various bioactive secondary metabolites. From the AcOEt‐soluble extract of Cladosporium oxysporum 170103, three new secopatulolides (1–3) and thirteen known compounds (4–16) were obtained. Their structures were established by detailed analysis of the NMR and HR‐ESI‐MS data. All sixteen compounds were tested for antibacterial activity against Vibrio parahemolyticus, ergosterol (10) presented moderate effect with the minimum inhibitory concentration (MIC) of 32 μM. It can destruct the membrane integrity of Vibrio parahemolyticus to change the cell shape.
Reduction in 90 day readmission rates utilizing ambulatory pulmonary pressure monitoring
Authors: Valika Ali , Sulemanjee Nasir , Pedersen Rachel , Heidenreich Debra 
Published: November 2022

AbstractAimsIn the CHAMPION (CardioMEMS Heart Sensor Allows Monitoring of Pressure to Improve Outcomes in New York Heart Association Functional Class III Heart Failure Patients) trial, heart failure hospitalization (HFH) rates were lower in patients with ambulatory pulmonary artery pressure (PAP) monitoring guidance. We investigated the effect of ambulatory haemodynamic monitoring on 90 day readmission rates after HFH.Methods and resultsWe retrospectively analysed patients across the Advocate Aurora Health hospital network who had undergone PAP sensor implantation between 1 October 2015 and 31 October 2019. Patients with a ventricular assist device (VAD) or transplant prior to implantation were excluded. Rates of total HFH and 30 and 90 day all‐cause readmission up to 12 months after implantation were collected, while censoring for an endpoint of heart transplantation, VAD, or death. Event rates were compared using Poisson regression. Of 459 patients included, there were 404 HFHs before and 179 after implantation. Compared with pre‐implantation, 30 day all‐cause readmission [incidence rate ratio (IRR): 0.55 (0.39–0.77), P = 0.0006] and 90 day all cause readmission rates were lower post‐implantation [IRR: 0.45 (0.35–0.58), P < 0.0001]. The effect of PAP sensor implantation on 90 day all‐cause readmission incidence rates was consistent across multiple subgroups.ConclusionsAcross a large hospital network, ambulatory haemodynamic monitoring was associated with lower HFH rates, as well as 30 and 90 day all‐cause readmission rates. This supports the utility of ambulatory PAP monitoring to improve HF management in the era of value‐based medicine.
Mendelian Disorders in an Interstitial Cystitis/Bladder Pain Syndrome Cohort
Authors: Estrella Elicia , Rockowitz Shira , Thorne Marielle , Smith Pressley , Petit Jeanette , Zehnder Veronica , Yu Richard N. , Bauer Stuart , Berde Charles , Agrawal Pankaj B. , Beggs Alan H. , Gharavi Ali G. , Kunkel Louis , Brownstein Catherine A. 
Published: November 2022

AbstractInterstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic pain disorder causing symptoms of urinary frequency, urgency, and bladder discomfort or pain. Although this condition affects a large population, little is known about its etiology. Genetic analyses of whole exome sequencing are performed on 109 individuals with IC/BPS. One family has a previously reported SIX5 variant (ENST00000317578.6:c.472G>A, p.Ala158Thr), consistent with Branchiootorenal syndrome 2 (BOR2). A likely pathogenic heterozygous variant in ATP2A2 (ENST00000539276.2:c.235G>A, p.Glu79Lys) is identified in two unrelated probands, indicating possible Darier‐White disease. Two private heterozygous variants are identified in ATP2C1 (ENST00000393221.4:c.2358A>T, p.Glu786Asp (VUS/Likely Pathogenic) and ENST00000393221.4:c.989C>G, p.Thr330Ser (likely pathogenic)), indicative of Hailey‐Hailey Disease. Sequence kernel association test analysis finds an increased burden of rare ATP2C1 variants in the IC/BPS cases versus a control cohort (p = 0.03, OR = 6.76), though does not survive Bonferroni correction. The data suggest that some individuals with IC/BPS may have unrecognized Mendelian syndromes. Comprehensive phenotyping and genotyping aid in understanding the range of diagnoses in the population‐based IC/BPS cohort. Conversely, ATP2C1, ATP2A2, and SIX5 may be candidate genes for IC/BPS. Further evaluation with larger numbers is needed. Genetically screening individuals with IC/BPS may help diagnose and treat this painful disorder due to its heterogeneous nature.
Multisitetest–retestreliability and compatibility of brain metrics derived fromFreeSurferversions 7.1, 6.0, and 5.3
Authors: Haddad Elizabeth , Pizzagalli Fabrizio , Zhu Alyssa H. , Bhatt Ravi R. , Islam Tasfiya , Ba Gari Iyad , Dixon Daniel , Thomopoulos Sophia I. , Thompson Paul M. , Jahanshad Neda 
Published: November 2022

AbstractAutomatic neuroimaging processing tools provide convenient and systematic methods for extracting features from brain magnetic resonance imaging scans. One tool, FreeSurfer, provides an easy‐to‐use pipeline to extract cortical and subcortical morphometric measures. There have been over 25 stable releases of FreeSurfer, with different versions used across published works. The reliability and compatibility of regional morphometric metrics derived from the most recent version releases have yet to be empirically assessed. Here, we used test–retest data from three public data sets to determine within‐version reliability and between‐version compatibility across 42 regional outputs from FreeSurfer versions 7.1, 6.0, and 5.3. Cortical thickness from v7.1 was less compatible with that of older versions, particularly along the cingulate gyrus, where the lowest version compatibility was observed (intraclass correlation coefficient 0.37–0.61). Surface area of the temporal pole, frontal pole, and medial orbitofrontal cortex, also showed low to moderate version compatibility. We confirm low compatibility between v6.0 and v5.3 of pallidum and putamen volumes, while those from v7.1 were compatible with v6.0. Replication in an independent sample showed largely similar results for measures of surface area and subcortical volumes, but had lower overall regional thickness reliability and compatibility. Batch effect correction may adjust for some inter‐version effects when most sites are run with one version, but results vary when more sites are run with different versions. Age associations in a quality controlled independent sample (N = 106) revealed version differences in results of downstream statistical analysis. We provide a reference to highlight the regional metrics that may yield recent version‐related inconsistencies in published findings. An interactive viewer is provided athttp://data.brainescience.org/Freesurfer_Reliability/.
The role of Vertebral Augmentation Procedures in the management of vertebral compression fractures secondary to multiple myeloma
Authors: Eseonu Kelechi C. , Panchmatia Jaykar R. , Streetly Matthew J. , Grauer Jonathan N. , Fakouri Bahram 
Published: November 2022

AbstractMultiple myeloma (MM) is a systemic disorder characterised by proliferation of B‐lymphocytes and plasma cells in the bone marrow. The primary aims of the management of spinal lesions in MM are pain control and fracture stabilisation. Vertebral augmentation procedures (VAP) can be subdivided into percutaneous vertebroplasty (VP) and balloon kyphoplasty (BKP). BKP involves the placement of orthopaedic balloons into the fractured vertebral body, creating a void into which polymethylmethacrylate bone cement is injected. This review outlines the management of spinal lesions in patients with MM, with a focus on the comparative risks and efficacy of vertebroplasty (VP) and balloon kyphoplasty (BKP). Soft tissue masses in MM are highly radiosensitive. Bisphosphonates and newer oncological therapies have decreased the indications for palliative radiotherapy, while spinal bracing can be utilised in selected cases to provide stability. BKP and VP provide equivalent long term pain control after MM vertebral compression fractures (VCF). BKP is superior to non‐operative management and VP for restoration of vertebral body height and prevention of segmental kyphosis. Current evidence suggests a greater degree of correction of kyphotic deformity and restoration of mid vertebral height (MVH) with BKP when compared with VP. The literature supports the use of BKP even in the presence of posterior vertebral body wall (PVBW) fractures, a group previously considered a contraindication to VAP. Superior functional outcomes have been reported in patients undergoing early versus delayed BKP (<6–8 weeks). Current evidence supports a lower risk of cement extrusion with BKP than with VP, but serious complications following VAP are rare. MM spinal pathology should be managed in a multidisciplinary setting. Surgical decompression and instrumentation are rarely indicated, due to the radio‐sensitivity of soft tissue lesions in MM. BKP is a safe and effective procedure for VCF secondary to MM.
The effect of weight loss interventions for obesity on fertility and pregnancy outcomes: A systematic review and meta‐analysis
Authors: Boyle Bonnie R. , Ablett Andrew D. , Ochi Christiantus , Hudson Jemma , Watson Laura , Rauh Diayne , Avenell Alison 
Published: November 2022

AbstractBackgroundWeight loss could improve fertility, perhaps by reducing insulin resistance.ObjectivesTo assess the effect of weight loss interventions on fertility in women with obesity not recruited because of known infertility.Search StrategyThree databases during 1966–2020, trial registry.Selection CriteriaRandomized controlled trials (RCTs) with a follow‐up of 1 year or more, with a mean cohort BMI of 30 kg/m2 or above.Data Collection and AnalysisA systematic review and meta‐analysis was conducted. The primary outcome was pregnancy. The secondary outcome was weight change.Main ResultsA total of 27 RCTs (5938 women) were included. Weight loss interventions showed no statistically significant increase in pregnancies compared to control interventions (24 trials, 97 women with pregnancy; risk ratio [RR] 1.43, 95% confidence interval [CI] 0.91–2.23); weight change (mean difference [MD] −2.36 kg, 21 trials, 95% CI −3.17 to −1.55). Compared with low‐fat diets, very‐low‐carbohydrate diets showed no statistically significant effect on women with pregnancy (three trials, 14 women with pregnancy; RR 1.37, 95% CI 0.49–3.84) or weight change (MD −0.32 kg, 95% CI −3.84 to 3.21).ConclusionsDiet‐based weight loss interventions for women with obesity not recruited because of infertility were effective at producing long‐term weight loss. The effects on fertility were not statistically significant, but few trials provided data. Weight loss trials should routinely collect fertility outcomes.Systematic review registrationPROSPERO CRD42017078819.
Constructing a personalized recommender system for life insurance products with machine‐learning techniques
Authors: Kong Hyeongwoo , Yun Wonje , Joo Weonyoung , Kim Ju‐Hyun , Kim Kyoung‐Kuk , Moon Il‐Chul , Kim Woo Chang 
Published: November 2022

SummaryThe collaborative filtering (CF) recommendation algorithm predicts the purchases of specific users based on their characteristics and purchase history. This study empirically analyzes the possibility of applying CF to the insurance industry using real customer data from South Korea. Using three different CF models, we examined the relevance of applying the CF model to insurance products under various situations by comparing them with logistic‐regression‐based recommendation models. Through experiments, we empirically show that CF models apply to the insurance industry, especially when customer purchase information is added to the model.
The effect of internal control and corporate social responsibility on conditional accounting conservatism: Evidence from France
Authors: Boulhaga Mounia , Elbardan Hany , Elmassri Moataz 
Published: November 2022

AbstractThis study examines the impact of internal control (IC) and corporate social responsibility (CSR) on conditional accounting conservatism (CAC). We employ legitimacy theory to understand whether managers adopt CSR reports and IC systems to seek legitimacy through symbolic actions or whether they do so to provide substantive actions to their stakeholders.We adopt a multivariate analysis for a sample of 98 French companies belonging to the SBF 120 index during the period between 2012 and 2021. All accounting and stock market information is extracted from the Thomson Reuter database (Datastream) and the Thomson Reuters ASSET4 ESG database. We found that both IC and CSR have a negative and significant impact on CAC; hence, managers may use CAC levels as a legitimizing tool for corporate activities. French companies are generally characterized by strong IC systems, suggesting a low demand for conditional conservatism. Socially responsible companies may have fewer agency issues and therefore will not practice accounting conservatism (AC) in a pronounced way. Distinct from the previous literature, our study examines the impact of IC as well as CSR on CAC, which provides useful insights regarding how stakeholder pressure, in terms of reporting on social responsibility and maintaining effective control systems, interacts with and impacts upon managers’ decisions to adopt CAC in the French context. Given the position of France after Brexit and the new laws adopted regarding an emphasis on the social dimension in corporate reporting, protecting stakeholders’ interests, and adopting conservatism, it is worth using such a context to gain a better understanding of AC, as this will enrich the literature.