bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of myeloid neoplasia with doxorubicin and cytarabine in 11 dogs
Authors: Matsuyama Arata , Beeler‐Marfisi Janet , Wood R. Darren , Richardson Danielle , Calvalido Jerome , Mutsaers Anthony J. , Bienzle Dorothee 
Published: September 2022

AbstractMyelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML) are primary myeloid neoplasms in dogs generally considered to have a poor outcome. In this study, we assessed toxicity, efficacy and outcome of concurrent administration of doxorubicin and cytarabine in 11 dogs with myeloid neoplasia. Bone marrow specimens were reviewed by three pathologists and classified as either MDS (n = 2), high grade MDS/early AML (MDS/AML; n = 4) or AML (n = 5). The median number of treatment cycles was 5 (range 1–9) and resolution of cytopenia was reported in 7 of 11 dogs including 2 dogs with MDS, 2 dogs with MDS/AML, and 3 dogs with AML. The median duration of remission in the seven responders was 344 days (range 109–1428) and the median overall survival for all dogs was 369 days. Adverse events consisted of predominantly low‐grade gastrointestinal illness and myelosuppression. Three dogs developed grade V toxicity manifesting with heart failure (n = 2) at 369 and 1170 days after diagnosis and acute gastrointestinal side effects (n =1). Despite a limited sample size, these results suggest that a doxorubicin and cytarabine protocol may be considered as a therapeutic option in dogs with myeloid neoplasia. Protocol safety, in particular regarding myocardial toxicity, and efficacy should be further investigated.
Animal models for the study of acute cutaneous wound healing
Authors: Saeed Shayan , Martins‐Green Manuela 
Published: September 2022

AbstractThe process of wound healing is critical to maintaining homeostasis after injury. Although a considerable amount has been learned about this complex process, much remains unknown. Whereas, studies with human volunteers are ideal given the unique nature of the human skin anatomy and immune system, the lack of such clinical access has made animal models prime candidates for use in preclinical studies. This review aims to discuss the strengths and limitations of the commonly used mammalian species in wound healing studies: murine, rabbit and porcine. Thereafter, a survey of models of various acute wounds such as cutaneous, ear, and implant are presented and representative studies that use them are described. This review is intended to acquaint readers with the vast spectrum of models available, each of which has a distinct utility. At the same time, it highlights the importance of utilising clinical samples to complement investigations conducted in animal models. Through this strategy, it is hoped that forthcoming research may be more reflective of the acute wound healing process as it occurs in humans.
Pilot study: Utility of long‐wave infrared thermography as a correlate to transcutaneous oximetry for candidates of hyperbaric oxygen therapy
Authors: Heyboer Marvin , Kozminski Andrew G. , Pacelli Lauren D. , Wojcik Susan M. 
Published: September 2022

AbstractHyperbaric oxygen (HBO2) has been used as an adjunctive treatment for the care of advanced non‐healing diabetic foot ulcers (DFUs). A patient's in‐chamber transcutaneous oximetry measurement (TCOM) is currently the most effective predictor for response to HBO2 therapy but still excludes close to one in four patients who would benefit out of treatment groups when used for patient selection. Improving selection tools and criteria could potentially help better demonstrate HBO2 therapy's efficacy for such patients. We sought to identify if long‐wave infrared thermography (LWIT) measurements held any correlation with a patient's TCOM measurements and if LWIT could be used in a response prediction role for adjunctive HBO2 therapy. To investigate, 24 patients already receiving TCOM measurements were enrolled to simultaneously be imaged with LWIT. LWIT measurements were taken throughout each patient's therapeutic course whether they underwent only standard wound care or adjunctive HBO2 treatments. A significant correlation was found between in‐chamber TCOM and post‐HBO2 LWIT. There was also a significant difference in the post‐HBO2 LWIT measurement from 1st treatment to 6 weeks or the last treatment recorded. These initial findings are important as they indicate a possible clinical use for LWIT in the selection process for patients for HBO2 therapy. Larger studies should be carried out to further articulate the clinical use of LWIT in this capacity.
A large diffusion and small amplification dynamics for density classification on graphs
Authors: Leal Laura , Montealegre Pedro , Osses Axel , Rapaport Ivan 
Published: September 2022

The density classification problem on graphs consists in finding a local dynamics such that, given a graph and an initial configuration of 0’s and 1’s assigned to the nodes of the graph, the dynamics converge to the fixed point configuration of all 1’s if the fraction of 1’s is greater than the critical density (typically 1/2) and, otherwise, it converges to the all 0’s fixed point configuration. To solve this problem, we follow the idea proposed in [R. Briceño, P. M. de Espanés, A. Osses and I. Rapaport, Physica D 261, 70 (2013)], where the authors designed a cellular automaton inspired by two mechanisms: diffusion and amplification. We apply this approach to different well-known graph classes: complete, regular, star, Erdös–Rényi and Barabási–Albert graphs.
Gas kinetics of galactic disks explains rotation curves of S-type galaxies without a need for dark matter
Authors: Lipovka Anton A. 
Published: September 2022

In this paper, I show that the generally accepted methods of classical mechanics are not applicable for calculating the outer parts of the rotation curves (RCs) of galaxies, where the influence of collisions on gas dynamics becomes dominant. In addition, the hydrodynamic approach cannot be used for this purpose due to an extreme rarefaction of the gas. I develop a new approach for describing the gas dynamics in outer regions of galactic disks, where the gas dynamics is determined mainly by collisions. Equations (free from restrictions imposed on hydrodynamics) are obtained that describe the dynamics of rarefied gas. The resulting equation [Formula: see text] (14) relates two quantities: the tangential velocity of the gas as a function of the distance from the center of a galaxy (RC) and the radial distribution of the gas density. It is shown that if the physical properties of the rarefied gas are properly taken into account, then dark matter (DM) is not required, and the “nonphysical” (non-Keplerian) RCs of the outer parts of the galactic disks are tailwinds that can be described within the framework of conventional gas kinetics. To illustrate the correctness of the obtained model, two galaxies with flat RCs (NGC7331 and NGC3198) are considered. From the observed RCs, using Eq. ( 14 ), the radial densities of the gas are calculated. An excellent agreement was obtained between the calculated gas densities and their observed values, which is a serious argument in favor of the developed model. Thus, the nonphysical RCs of spiral galaxies represent the tailwinds of gas, the dynamics of which is naturally described by the kinetic equation without involving the concept of DM. Total masses of two galaxies NGC7331 and NGC3198 have been calculated. Implications for cosmology are discussed.
Analytical View of Pricing Weather and Freight Derivatives: 1950–2020
Authors: Satya Sekhar G. V. 
Published: September 2022

A weather derivative is financial instrument that companies or individuals use to hedge against the risk of weather-related losses. Freight derivatives value is derived from the future levels of freight rates, like a dry bulk-a category of cargo stowed in bulk, consisting of grain, cotton, coal, etc., carrying rates, and oil tanker rates.Numerous empirical studies exist on weather and freight derivatives and their pricing models such as Indifference Pricing Approach, Arbitrage Pricing Model, Financial Pricing model, Benchmark Pricing Approach, Fair Pricing Approach, Actuarial Pricing, Consumer Based Pricing Method, and Index Modeling. This paper aims to address issues relating to the functioning of weather and freight derivatives.This paper also focuses on the studies published on weather and freight derivatives’ pricing models during the last seven decades (i.e., 1950–2020).Objectives:(1) To understand the vital issues relating to models of weather and freight derivatives. (2) To compare pricing models of weather and freight derivatives during the last seven decades (i.e., 1950–2020).
PHYSIOLOGICAL PARAMETERS AND SEVERITY OF CORONAVIRUS INFECTION: CASE STUDY
Authors: HADI AMEER M. , AL-MAWLA YASI HAIDER , AL-IMARI MUSTAFA JAWAD , ABBOOD SARAH KAMIL , ALSAFFAR MARWA FADHIL 
Published: September 2022

Preface: Coronavirus has several mechanisms that facilitate its entry into the target cell such as cholesterol by acting concurrently with angiotensin-converting enzyme (ACE2) at entry site, where the virus uses it to increase its entry and spread. We conducted a practical research for measuring Cholesterol, Triglyceride (TG) and Lactate dehydrogenase concentrations in COVID-19 patients. Objectives: The aim of this research is to see the correlation between Cholesterol, TG and Lactate dehydrogenase and the severity of coronavirus infection. Methods: This study is made at Al-Zahra Teaching Hospital during the period from March 2021 to July 2021 and it was performed on two groups: patients group that involved 30 samples (15 male and 15 female), age ranging from 18 to 84 years old and another group consisting of 30 individuals who were not infected with SARS-CoV-2. Results: Our findings show that the high value for markers under this study associated with coronavirus was detected in lactate dehydrogenase ([Formula: see text] IU/l), ([Formula: see text] Mg/dl) for TG and ([Formula: see text] Mg/dl) for cholesterol. High concentration of cholesterol is shown in the age category between 54 and 64 years is represented as (487 Mg/dl and 502 Mg/dl), TG at ages 42, 54 and 64 years is represented as 497, 509 and 521 Mg/dl, Lactate dehydrogenase at ages 80–84 years that represented is as 739, 809 and 812 IU/l. According to physiological parameters which were elevated, a high concentration was observed in almost both sexes, as males were more affected than females when determining cholesterol at (500 Mg/dl), while females had more than males with respect to lactate dehydrogenase and TGs at (520 Mg/dl and 800 IU/l), respectively. In the correlation test, we found the highest significant differences, according to the correlation test, between cholesterol and lactate dehydrogenase at (1) cholesterol and TG at (0.000), TG and lactate dehydrogenase at (0.739). Conclusions: We conclude that COVID-19 patients suffer from increased markers under the studies on cholesterol, TG and lactate dehydrogenase.
On disjoint maximum and maximal independent sets in graphs and inverse independence number
Authors: Kaci Fatma 
Published: September 2022

In this paper, we give a class of graphs that do not admit disjoint maximum and maximal independent (MMI) sets. The concept of inverse independence was introduced by Bhat and Bhat in [Inverse independence number of a graph, Int. J. Comput. Appl. 42(5) (2012) 9–13]. Let [Formula: see text] be a [Formula: see text]-set in [Formula: see text]. An independent set [Formula: see text] is called an inverse independent set with respect to [Formula: see text]. The inverse independence number [Formula: see text] is the size of the largest inverse independent set in [Formula: see text]. Bhat and Bhat gave few bounds on the independence number of a graph, we continue the study by giving some new bounds and exact value for particular classes of graphs: spider tree, the rooted product and Cartesian product of two particular graphs.
Illegal Immigration with Tariff Distortions
Authors: Woodland Alan , Yoshida Chisato 
Published: September 2022

We construct and analyse a two-country general equilibrium model in which the home and foreign countries trade two final goods, and legal immigration is restricted. International trade is distorted via tariffs imposed by both countries. Foreign migrants attempt illegal entry to the home country but face a probability of detection and arrest by border patrol of the home country. We examine how stricter border patrol affects the level of illegal immigration, establish conditions under which stricter border patrol reduces successful illegal immigration and determine the welfare implications of this policy change. We also determine the effects on illegal immigration and the welfare of all agents when illegal immigrants increase remittances back to the source country. JEL Codes: F13, F16, F22.
Saving Household Production-Cum-Consumption Time: Implications for International Trade in Trash
Authors: Van Long Ngo 
Published: September 2022

This article revisits Kemp’s and Tran-Nam’s incorporation into trade theory the Gossenian theme that consumption takes time. We show how the substitutability between time-intensive household-produced consumption goods and time-saving commercially produced consumption goods (which save households’ consumption and production time) together with capital accumulation can lead to an increase in trash and international trade in trash. The applicability of the standard gains from trade theorems is shown to be compromised by the externalities associated with international trade in trash between North and South. Under some parameter values, South is better off under autarky than under free trade in trash and the gains from trade by North is not sufficient to compensate South’s loss from trade. JEL Codes: D13, F18, F13
Trade Data Falsification and Informal Capita Movement: A Study of Bangladesh with Major Asian Trade Partners
Authors: Das Samir Kumer , Biswas Amit K. 
Published: September 2022

The imposition of restrictive trade policies and consequent fabrication of foreign trade statistics acts as hindrance for effective policy formulations in the developing countries. This article presents the trade misreporting scenario of Bangladesh in relation to major Asian trade partner countries (China, India and Singapore) between 1973 and 2018 and examines the possibilities of informal capital movements across borders. Using the vector autoregression (VAR) and autoregressive distributed lag (ARDL) models, we first build partner-level exercise, followed by a combined panel, and find that spot and forward exchange rates, custom duties and real interest rate differences between foreign and home largely affect trade misreporting rates. Interestingly, we also find that the values of past import under-invoicing might also lead to export under-invoicing and vice versa, a two-way causal relationship. JEL Codes: F14, F68, C10, C52
Sexuality and psychological well-being in different polycystic ovary syndrome phenotypes compared with healthy controls: a cross-sectional study
Authors: Bahadori Fatemeh , Jahanian Sadatmahalleh Shahideh , Montazeri Ali , Nasiri Malihe 
Published: September 2022

Abstract
Introduction
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. The present study aimed to compare the women with different PCOS phenotypes with the healty group in terms of sexual function, depression, anxiety and quality of life scale.

Materials and methods
The present cross-sectional study was carried out on 192 women with PCOS (classified on the basis of Rotterdam criteria into four categories) and 50 healthy controls. All participants were asked to fill out the valid and reliable questionnaires of FSFI (Female Sexual Function Index), HADS (Hospital Depression and Anxiety Scale) and SF-12.

Results
In the HADS questionnaire, phenotype B achieved the highest mean score in anxiety and depression domains, whereas, phenotype B had the lowest mean score in the FSFI and SF-12 quassionnaires. Furthermore, there was a significant difference between the women with PCOS phenotypes and the control grroup in arousal, lubrication, pain, and mean total score of FSFI (P < 0.05). In regression logistic analysis, age, infertility and depression were predictors of sexual dysfunction (P < 0.05).

Conclusion
The results indicated significant differences in terms of sexual dysfunction, depression, anxiety and quality of life in the women suffering from different phenotypes of PCOS compared with the healthy group. These results provide evidence that care and recommendations for improving women’s QoL and sexual function should be considered according to the relevant PCOS phenotypes.
Exploring the relationship between autophagy and Gefitinib resistance in NSCLC by silencing PDLIM5 using ultrasound-targeted microbubble destruction technology
Authors: Zhang Yao , Lv Wenhao , Li Hui , Dong Tiantian , Wu Hao , Su Chunhong , Shu Hong , Nie Fang 
Published: September 2022

Abstract
Background
Ultrasound-targeted microbubble destruction (UTMD) technology is a new drug and gene delivery strategy. This study investigates novel ultrasound (US) sensitive siRNA-loaded nanobubbles (siRNA-NBs) to explore the relationship between PDLIM5 mediated autophagy and drug resistance development using epidermal growth factor tyrosine kinase inhibitors (EGFR-TKIs) in the treatment of non-small cell lung cancer (NSCLC).

Methods
US sensitive siRNA-NBs were designed to inhibit the expression of PDLIM5 in gefitinib-resistant human NSCLC PC9GR cells in vitro. The expression of autophagy-related proteins (P62 and LC3-II/I) and autophagosomes in PC9GR cells after PDLIM5 gene silencing were explored.

Results
US-sensitive PDLIM5-targeted siRNA-NBs were effectively delivered into PC9GR cells, inhibiting PDLIM5 expression, increasing LC3-II/I and p62 expressions and increasing autophagosomes in PC9GR cells in vitro.

Conclusions
Using UTMD, US-sensitive siRNA-NBs have the potential as an ideal delivery vector to mediate highly effective RNA interference for NSCLC cells. Furthermore, PDLIM5 plays a role in the autophagy-mediated resistance in gefitinib-resistant PC9GR cells.
Strategies for cost-effectiveness analysis of rehabilitation for older patients with acute heart failure
Authors: Sakai Kotomi , Momosaki Ryo , Hoshino Eri 
Published: September 2022

AbstractThe prevalence of heart failure (HF) is increasing in the ageing world population, and its burden on the medical and health economic fields is enormous. Rehabilitation is an essential component of the nonpharmacological treatment of patients with HF; however, its efficacy and cost-effectiveness for patients with acute HF remain unclear. A trial assessed the cost-effectiveness of acute cardiac rehabilitation among older adults. Herein, we discussed strategies for the cost-effectiveness analysis of acute cardiac rehabilitation using the rehabilitation therapy in older acute heart failure patients trial.
Success and failures in MRSA infection control during the COVID-19 pandemic
Authors: Kavanagh Kevin T. , Cormier Lindsay E. 
Published: September 2022

AbstractPrivate sector facilities in the United States have experienced a resurgence of Methicillin-resistant Staphylococcus aureus (MRSA) hospital-onset infections during the COVID-19 pandemic, which eliminated all gains that were achieved over the last decade. The third quarter of 2021, the Standardized Infection Ratio for hospital onset MRSA bloodstream infections was 1.17, well above the baseline value of 1.0. In contrast, the Veterans Health Administration (VHA) has been able to maintain its mitigation efforts and low rates of MRSA hospital-onset infections through the second quarter of fiscal year 2022 (Mar. 31, 2022), the most recent available data. The difference may be explained not only by the VHA’s use of uniform mitigating policies which rely on active surveillance and contact precautions, but also on the VAH’s ability to maintain adequate staffing during the pandemic. Future research into MRSA mitigation is warranted and this data supports the need for healthcare system transformation.
Illegal waste fly-tipping in the Covid-19 pandemic: enhanced compliance, temporal displacement, and urban–rural variation
Authors: Dixon Anthony C. , Farrell Graham , Tilley Nick 
Published: September 2022

AbstractObjectiveIllegal dumping of household and business waste, known as fly-tipping in the UK, is a significant environmental crime. News agencies reported major increases early in the COVID-19 pandemic when waste disposal services were closed or disrupted. This study examines the effect of lockdowns on illegal dumping in the UK.MethodA freedom of information request was sent to all local authorities in the UK asking for records of reported incidents of fly-tipping for before and after the first national lockdown. ARIMA modelling and year-on-year comparison was used to compare observed and expected levels of fly-tipping. Urban and rural local authorities were compared.ResultsA statistically significant decline in fly-tipping during the first lockdown was followed by a similar increase when lockdown ended. The effects largely cancelled each other out. There was pronounced variation in urban–rural experience: urban areas, with higher rates generally, experienced most of the initial drop in fly-tipping while some rural authorities experienced an increase.ConclusionWaste services promote compliance with laws against illegal dumping. When those services were disrupted during lockdown it was expected that fly-tipping would increase but, counter-intuitively, it declined. This enhanced compliance effect was likely due to increased perceived risk in densely populated urban areas. However, as lockdown restrictions were eased, fly-tipping increased to clear the backlog, indicating temporal displacement.