bluuebunny/crossref_metadata_2025_split huggingface dataset:
A big data-driven eHealth approach to prevent, detect, and reduce atherosclerotic cardiovascular disease burden
Authors: Scheenstra B , Bruninx A , Van Daalen F , Stahl N , Latuapon E , Townend D , Bermejo I , Dekker A , Spreeuwenberg M , Maessen J , Van 'T Hof A , Kietselaer B 
Published: May 2022

Abstract

Funding Acknowledgements
Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Netherlands Organisation for Scientific Research (NWO)
eHealth is a promising tool to support citizens and patients to reduce their risk of future atherosclerotic vascular disease (ASCVD). Currently, many eHealth initiatives are developed, however their use is limited. To improve the adoption of eHealth initiatives, personalization is needed according to preferences and understanding of the individual. Together with stakeholders, we used the design thinking method to create a dream user-scenario for an eHealth solution to improve cardiovascular outcomes. This point-of-view shows the essential concepts of such an eHealth initiative and focuses on scientific solutions and the most important challenges faced during its development.
In the user-scenario a federated data infrastructure collects distributed medical and non-medical data from different organizations, while ensuring maximal privacy. This data, that is currently not available, is used in a screening model to identify citizens with an increased risk for ASCVD. Citizens at risk are offered the use of an eCoach, which is connected to a counterfactual prediction model to calculate a residual risk for hypothetical interventions. This risk is visualized in a personalized way to support the shared decision making process of personalized lifestyle and healthcare goals. eHealth modules, integrated in the eCoach, encourages the patient in achieving these goals. Relevant outcomes are monitored and are used to adjust the intensity of the modules and follow-up accordingly. To realize this federated data infrastructure, an ethical and legal framework should be developed to ensue responsible data handling.
Triglycerides, polymorphisms and the risk of acute coronary syndrome in the Czech population
Authors: Todorovova V , Dlouha L , Hubacek JA , Satny M , Adamkova V , Pitha J , Ceska R , Vrablik M 
Published: May 2022

Abstract

Funding Acknowledgements
Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Supported by Ministry of Health, Czech Republic - conceptual development of research organization 64165, General University Hospital in Prague, Czech Republic

Background and Aims
Elevated levels of plasma triglycerides (TG) have been identified as a risk factor for the development of cardiovacular disease, including acute coronary syndrome (ACS). Final TG levels are largely influenced by genetic factors. The most important genetic factors influencing TG levels in the Czech population are the polymorphisms in APOA5, GCKR, MAP3K1, CTF1, CYP26A1, LRP1, CILP2, LIPC, APOE, GALNT2 and LPL genes.

Methods
The variants in mentioned genes were analyzed in total 929 patients with ACS and 936 healthy controls (study post-MONICA). Only adult men under the age of 65 were included in the study.

Results
Plasma TG levels did not differ significantly between patients and controls (1.96 ± 1.30 mmol/L vs. 2.06 ± 1.47 mmol/L). CYP26A1 AA homozygotes (rs2068888) were more common (P &lt;0.05; OR; 95% CI = 1.34; 1.03-1.74) among patients. The differences in the frequencies of the other variants were not statistically significant, however, with the exception of GCKR, LRP1, MAP3K1, GALNT2 and LPL variants, they were used to calculate the risk genetic score due to the higher OR value (above 1.15). Subjects with a score of 8 or more vs less than 3 occurred more frequently among patients with ACS than among controls (60% vs. 30%, P = 0.005; OR; 95% CI – 2.03; 1.24 – 3.31).

Conclusions
Genetic score calculated from six selected variants associated with plasma TG levels is a significant predictor of ACS in Czech Caucasian males.
A randomized trial of non-fasting vs. fasting for cardiac implantable electronic device procedures (Fast-CIED Study)
Authors: Bode Kerstin , Gerhards Matthias , Doering Michael , Lucas Johannes , Tijssen Jan , Dagres Nikolaos , Hilbert Sebastian , Richter Sergio , Nedios Sotirios , Lurz Julia , Moscoso-Luduena Cathleen , Arya Arash , Shamloo Alireza Sepehri , Hindricks Gerhard 
Published: May 2022

Abstract

Aims
Data on safety and efficacy of a non-fasting strategy in minimal invasive cardiac procedures are lacking. We assessed a non-fasting strategy compared with a fasting strategy regarding patient’s well-being and safety in elective cardiac implantable electronic device (CIED) procedures.

Methods and results
In this randomized, single-blinded clinical trial, 201 patients (non-fasting = 100, fasting = 101) with a mean age of 72.0 ± 11.6 years (66.7% male) were assigned to a non-fasting strategy (solids/fluids allowed up to 1 h) or a fasting strategy (at least 6 h no solids and 2 h no fluids) before the procedure and analysed on an intention-to-treat basis. The co-primary outcomes were patients’ well-being scores (based on numeric rating scale, 0–10) and incidence of intra-procedural food-related adverse events, including vomiting, perioperative pulmonary aspiration, and emergency intubation. Renal, haematological, and metabolic blood parameters and 30-day follow-up data were gathered. The summed pre-procedural patients’ well-being score was significantly lower in the non-fasting group [non-fasting: 13.1 ± 9.6 vs. fasting: 16.5 ± 11.4, 95% confidence interval (CI) of mean difference (MD) −6.35 to −0.46, P = 0.029], which was mainly driven by significantly lower scores for hunger and tiredness in the non-fasting group (non-fasting vs. fasting; hunger: 0.9 ± 1.9 vs. 3.1 ± 3.2, 95% CI of MD −2.86 to −1.42, P &lt; 0.001; tiredness: 1.6 ± 2.3 vs. 2.6 ± 2.7, 95% CI of MD −1.68 to −0.29, P = 0.023). No intra-procedural food-related adverse events were observed. Relevant blood parameters and 30-day follow-up did not show significant differences.

Conclusion
These results showed that a non-fasting strategy is beneficial to a fasting one regarding patient’s well-being and comparable in terms of safety for CIED procedures (NCT04389697).
Abnormal depletion of terrestrial water storage and crustal uplift owing to the 2019 drought in Yunnan, China
Authors: Su Guangli , Zhan Wei 
Published: May 2022

SUMMARYDroughts are natural disasters that cause severe economic and social impacts. Analysing changes in terrestrial water storage (TWS) before and after typical drought events is important for understanding the principles of the regional terrestrial water transport law and drought response, and for providing scientific agricultural production guidance. Yunnan is a drought-prone region, and high temperatures and low rainfall in 2019 led to a severe drought. Precipitation data showed that the wet season in Yunnan started 1 month later than usual in 2019. Moreover, 52 per cent (205 000 km2) of the total area of Yunnan experienced a cumulative precipitation anomaly (PA; in percentage) of −30 per cent between January and May. In this study, we used data from the Gravity Recovery and Climate Experiment (GRACE) and Gravity Recovery and Climate Experiment Follow-On (GRACE-FO) missions to identify the spatial and temporal variations in TWS before and after the 2019 drought. Our results show that the drought led to an average reduction of 125 mm (equivalent water height) in the TWS, with the greatest loss in southern Yunnan, with a maximum loss of 272 mm. The reduced TWS caused by the delayed and anomalously weak southwest monsoon in 2019 gradually spread from the southwest to the northeast. By comparing with the drought in 2009–2010, we find that the southern Yunnan with abundant rainfall is more vulnerable to drought and has a relatively larger deficit in TWS. Furthermore, we used GRACE and GRACE-FO data to invert the crustal uplift caused by terrestrial water unloading in the 2019 drought, and found a maximum uplift of 8.4 mm. This showed a consistent spatial distribution with displacement variations recorded by 26 continuous Global Positioning System (GPS) stations in Yunnan during the same period, albeit slightly different in magnitude, indicating the potential of GPS for monitoring regional TWS changes.
Species targeting and discarding in mixed fisheries
Authors: Marchal Paul , Vermard Youen 
Published: May 2022

AbstractThis study examined some of the spatial patterns and temporal dynamics of species targeting and discarding, for the French bottom trawlers operating in the eastern English Channel, building on spatial overlaps (or mismatches) between fishing effort, survey-based biomass or abundance indices and discard rates. We first identified that cuttlefish (Sepia officinalis), squids (Loligo sp.) and, to a lesser degree, striped red mullet (Mullus surmuletus), and seabass (Dicentrarchus labrax) were the main targets, while fishing for historically important species was less attractive. This result was broadly in accord with catch compositions, although mackerel (Scomber scombrus) targeting was possibly underestimated. We also showed that the distributions of fishing effort and of undersized herring, plaice, and whiting did not overlap. Although fishing effort covered fishing grounds populated with undersized horse mackerel, the proportion of undersized individuals in the discards was small. Plaice and whiting discard rates overlapped in space with undersized abundance indices. Fishing effort may have avoided spatial units with potentially high plaice discard rates, which may have been driven by large proportions of undersized fish, but also by restricted access to coastal area. Overall, the EU Landing Obligation had limited effects on fishing effort allocation relative to either undersized abundance or discard rates distributions.
Construction of a hypoxia-immune-related prognostic model and targeted therapeutic strategies for cervical cancer
Authors: Xie Shuqian , Ding Bo , Wang Shiyuan , Zhang Xing , Yan Wenjing , Xia Qianqian , Meng Dan , Shen Siyuan , Yu Bingjia , Liu Haohan , Hu Jing , Wang Shizhi 
Published: May 2022

Abstract
Emerging evidence indicates that hypoxia and immunity play important roles in tumorigenesis and development. However, the hypoxia-immune-related prognostic risk model has not been established in cervical cancer (CC). We aimed to construct a hypoxia-immune-related prognostic risk model, which has potential application in predicting the prognosis of CC patients and the response to targeted therapy. The RNA-seq data and corresponding clinical information were retrieved from The Cancer Genome Atlas (TCGA) database. The hypoxia status and immune status of CC patients were evaluated using the Consensus Clustering method and single-sample gene set enrichment analysis (ssGSEA), respectively. The univariate Cox regression, least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression were applied to establish the prognostic risk model of CC. The chemotherapy response for six chemotherapeutic agents of each CC patient was calculated according to the Genomics of Drug Sensitivity in Cancer (GDSC). And the Connectivity Map (CMap) database was performed to screen candidate small-molecule drugs. In this study, we identified seven gene signatures (P4HA2, MSMO1, EGLN1, ZNF316, IKZF3, ISCU and MYO1B) with prognostic values. And the survival time of patients with low risk was significantly longer than those with high risk. Meanwhile, CC patients in the high-risk group yielded higher sensitivity to five chemotherapeutic agents. And we listed 10 candidate small-molecule drugs that exhibited a high correlation with the prognosis of CC. Thus, the prognostic model can accurately predict the prognosis of patients with CC and may be helpful for the development of new hypoxia-immune prognostic markers and therapeutic strategies for CC.
Distributional reinforcement learning with the independent learners for flexible job shop scheduling problem with high variability
Authors: Oh Seung Heon , Cho Young In , Woo Jong Hun 
Published: May 2022

Abstract
Multi-agent scheduling algorithm is a useful method for the flexible job shop scheduling problem (FJSP). Also, the variability of the target system has to be considered in the scheduling problem that includes the machine failure, the setup change, etc. This study proposes the scheduling method that combines the independent learners with the implicit quantile network by modeling of the FJSP with high variability to the form of the multi-agent. The proposed method demonstrates superior performance compared to the several known heuristic dispatching rules. In addition, the trained model exhibits superior performance compared to the reinforcement learning algorithms such as proximal policy optimization and deep Q-network.
The Fake One is the Real One: Finstas, Authenticity, and Context Collapse in Teen Friend Groups
Authors: Darr Christopher R , Doss Erin F 
Published: May 2022

Abstract
Research has shown that as individuals—particularly teenagers—navigate social media, they value authenticity, typically understood as congruence between their online and offline identities. Portraying oneself in an authentic manner, however, is complicated by the phenomenon of context collapse, where multiple audiences (e.g., friends, teachers, parents) become homogenized and boundaries become blurred. Drawing on focus group data with 20 teenagers aged 13–17, we examined how teens use Finstas (“fake Instagram” accounts) to navigate tensions between context collapse and authenticity. Our participants see themselves as quite skilled at creating idealized identities on their Rinstas (“real Instagram” accounts) but turn to Finstas because they find such performances unsatisfying, using these secondary accounts for active resistance to norms of mainstream Instagram, often through negative emotional expression and self-description. Our study adds to the literature on teen social media use by illuminating strategies teens use to navigate context collapse as they seek authenticity.
The Emergence of the qirāʾāt: The Divine Permission Hypothesis
Authors: Moqbel Tareq 
Published: May 2022

Abstract
Various theories for the emergence of the qirāʾāt (variant readings in the Qurʾān) have been suggested. This paper proposes another: the divine permission hypothesis. It shows that the Muslim scholarly tradition appears either to have taken for granted or all-but explicitly stated that the sending down of the Qurʾān was, from the beginning, accompanied by a divine concession permitting a measure of flexibility in its recitation. The paper presents some of the scholarly discussion on the restrictions or controls on this concession, including its being time-bound. The variant readings circulating during the lifetime of the Companions did not all carry the same divine authority—they ranged from those directly taught by the Prophet, to those he specifically approved, to those initiated by the Companions under the general authority of the divine permission. The permission hypothesis offers considerable explanatory efficiency. It allows us to take more of what is recorded in the Islamic tradition at face value; to accommodate the traditions that the Qurʾān was sent down predominantly in the dialect of Quraysh; to link up the seven aḥruf and qirāʾa bi-l-maʿnā traditions; to simplify some of the issues around the so-called ‘Companion codices’; to account for the existence, before the text was standardized, of an unspecified number of variants; to anticipate some of the directions taken in ʿilm al-qirāʾāt; and to make sense of the unease with and critique of qirāʾāt of such towering figures in Qurʾān scholarship as al-Ṭabarī and al-Zamaksharī.
The Quest to Eradicate HPV-Related Oropharyngeal Carcinoma: An Opportunity Not to Miss
Authors: Lalonde Chloe S , Teng Yong , Burtness Barbara A , Ferris Robert L , Ahmed Rafi , Saba Nabil F 
Published: May 2022

Abstract
Oropharyngeal squamous cell carcinoma (OPSCC) accounts for more than half of all head and neck cancers. Since the 1970s, OPSCC has shifted from an environmentally triggered to virally mediated disease due to a sharp rise in human papillomavirus (HPV)–related squamous cell carcinoma. Although a highly effective prophylactic vaccine is available, its current implementation is far below national targets, and OPSCC incidence is predicted to further increase by 2045. However, we believe that with prompt action now, we can not only defy these predictions but also effectively eradicate HPV-related OPSCC in these next 20 years. We herein provide an overview of the necessary elements to eliminate this disease: improved primary vaccine uptake, a 1-time universal vaccination effort, and implementation of novel therapeutics that have potential to cure existing disease.
The Association Between Sleep and Musculoskeletal Injuries in Military Personnel: A Systematic Review
Authors: Lisman Peter , Ritland Bradley M , Burke Tina M , Sweeney Lisa , Dobrosielski Devon A 
Published: May 2022

ABSTRACT

Introduction
Musculoskeletal injuries (MSKIs) are a significant health problem in the military. Accordingly, identifying risk factors associated with MSKI to develop targeted strategies that attenuate injury risk remains a top priority within the military. Insufficient sleep has garnered increased attention as a potential risk factor for MSKI in both civilians and military personnel. Yet, there are no systematic evaluations of the potential association between sleep and MSKI in the military. The purpose of this review is to examine the relationship between sleep and injury in military personnel.

Materials and Methods
Literature searches were performed in multiple electronic databases using keywords relevant to sleep quantity and quality, MSKI, and military populations. Two investigators independently assessed the methodological quality of each study using the Newcastle–Ottawa Scale for cohort studies or an adapted form of this scale for cross-sectional studies.

Results
The search yielded 2402 total citations, with 8 studies (3 cohort and 5 cross-sectional) fitting the inclusion criteria. Overall, the systematic review found 5 of the 8 reviewed studies supporting an association between sleep (quality and duration) and MSKI in military personnel. Specifically, poor sleep was associated with increased injury incidence in 2 cohort and 3 cross-sectional studies.

Conclusion
This is the first systematic review to evaluate the published literature on the association between sleep and MSKI risk in military populations. Although there is currently limited research on this topic, findings suggest that sleep is associated with MSKI and should be considered when designing strategies aimed at reducing MSKI risk in military personnel.
Intermediate- and high-velocity clouds in the Milky Way – II. Evidence for a Galactic fountain with collimated outflows and diffuse inflows
Authors: Marasco Antonino , Fraternali Filippo , Lehner Nicolas , Howk J Christopher 
Published: May 2022

ABSTRACTWe model the kinematics of the high- and intermediate-velocity clouds (HVCs and IVCs) observed in absorption towards a sample of 55 Galactic halo stars with accurate distance measurements. We employ a simple model of a thick disc whose main free parameters are the gas azimuthal, radial, and vertical velocities (vϕ, vR, and vz), and apply it to the data by fully accounting for the distribution of the observed features in the distance–velocity space. We find that at least two separate components are required to reproduce the data. A scenario where the HVCs and the IVCs are treated as distinct populations provides only a partial description of the data, which suggests that a pure velocity-based separation may give a biased vision of the gas physics at the Milky Way’s disc–halo interface. Instead, the data are better described by a combination of an inflow component and an outflow component, both characterized by rotation with vϕ comparable to that of the disc and vz of $50\!-\!100\, {\rm km\, s}^{-1}$. Features associated with the inflow appear to be diffused across the sky, while those associated with the outflow are mostly confined within a bicone pointing towards (l = 220°, b = +40°) and (l = 40°, b = −40°). Our findings indicate that the lower ($|z| \lesssim 10\, {\rm kpc}$) Galactic halo is populated by a mixture of diffuse inflowing gas and collimated outflowing material, which are likely manifestations of a galaxy-wide gas cycle triggered by stellar feedback, that is, the galactic fountain.
Deep radio-interferometric imaging with POLISH: DSA-2000 and weak lensing
Authors: Connor Liam , Bouman Katherine L , Ravi Vikram , Hallinan Gregg 
Published: May 2022

ABSTRACT
Radio interferometry allows astronomers to probe small spatial scales that are often inaccessible with single-dish instruments. However, recovering the radio sky from an interferometer is an ill-posed deconvolution problem that astronomers have worked on for half a century. More challenging still is achieving resolution below the array’s diffraction limit, known as superresolution imaging. To this end, we have developed a new learning-based approach for radio interferometric imaging, leveraging recent advances in the classical computer vision problems of single-image superresolution and deconvolution. We have developed and trained a high-dynamic range residual neural network to learn the mapping between the dirty image and the true radio sky. We call this procedure POLISH, in contrast to the traditional CLEAN algorithm. The feed-forward nature of learning-based approaches like POLISH is critical for analysing data from the upcoming Deep Synoptic Array (DSA-2000). We show that POLISH achieves superresolution, and we demonstrate its ability to deconvolve real observations from the Very Large Array. Superresolution on DSA-2000 will allow us to measure the shapes and orientations of several hundred million star-forming radio galaxies (SFGs), making it a powerful cosmological weak lensing survey and probe of dark energy. We forecast its ability to constrain the lensing power spectrum, finding that it will be complementary to next-generation optical surveys such as Euclid.
AlignMe: an update of the web server for alignment of membrane protein sequences
Authors: Staritzbichler René , Yaklich Emily , Sarti Edoardo , Ristic Nikola , Hildebrand Peter W , Forrest Lucy R 
Published: May 2022

Abstract
The AlignMe web server is dedicated to accurately aligning sequences of membrane proteins, a particularly challenging task due to the strong evolutionary divergence and the low compositional complexity of hydrophobic membrane-spanning proteins. AlignMe can create pairwise alignments of either two primary amino acid sequences or two hydropathy profiles. The web server for AlignMe has been continuously available for &gt;10 years, supporting 1000s of users per year. Recent improvements include anchoring, multiple submissions, and structure visualization. Anchoring is the ability to constrain a position in an alignment, which allows expert information about related residues in proteins to be incorporated into an alignment without manual modification. The original web interface to the server limited the user to one alignment per submission, hindering larger scale studies. Now, batches of alignments can be initiated with a single submission. Finally, to provide structural context for the relationship between proteins, sequence similarity can now be mapped onto one or more structures (or structural models) of the proteins being aligned, by links to MutationExplorer, a web-based visualization tool. Together with a refreshed user interface, these features further enhance an important resource in the membrane protein community. The AlignMe web server is freely available at https://www.bioinfo.mpg.de/AlignMe/.