bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of pulmonary arterial hypertension in severe chronic obstructive pulmonary disease patients attending tertiary care centre Ernakulam
Authors: George Jilse , V. Niranjan A. , Nair Tara B. , . Minhaj 
Published: February 2022

Background: Chronic obstructive pulmonary disease (COPD) is an irreversible bronchial inflammation of lung airways and parenchyma. Various factors play an important role in occurrence and severity of pulmonary arterial hypertension (PAH), a common in severe COPD. The objective of the study is to know the proportion of PAH in patients with severe COPD and to find the association between various factors.Methods: 180 cases of severe COPD patients admitted in Government Medical College Ernakulum from January 2019-December 2019, were enrolled into this cross-sectional descriptive study. Subject’s history, clinical examination, anthropometric measurements, vitals, Arterial Blood Gas (ABG) analysis were done.Results: Among 180 subjects, 148 (82.22%) had mild PAH, 22 (12.22%) subjects had moderate PAH and 10 (5.56%) had severe PAH. Use of accessory muscle was the most elicited sign in the study with 174 (96.67%). 170 (94.44%) had cough and 169 (93.89%) had breathlessness which were the most reported symptoms. Demographic variables and clinical features had no significant mean pulmonary artery pressure (mPAP) association. Grade 3 PAH groups were elder than others, which was statistically significant (p<0.047). FEV1, Oxygen Saturation and ejection fraction were lowest in grade 3 PAH subjects. Respiratory rate, hemoglobin, PCV, tricuspid velocity, PaCO2 were highest in grade 3 PAH subjects being statistically significant (p<0.0001).Conclusions: In our study, majority of severe COPD patients had mild PAH. There was an independent correlation between respiratory rate, hemoglobin, PCV, tricuspid regurgitant velocity and PaCO2 with severity of PAH.
Nutrimentum vascularum as pulsatile tinnitus
Authors: Narayankar Nivedita M. , V. Chandre Gowda B. , Rai S. Juthika 
Published: February 2022

<p>Tinnitus is one of the most common otological symptoms encountered in otorhinolaryngology. In recent times our understanding of tinnitus has significantly progressed but nonetheless, it still constitutes a very incapacitating symptom which greatly affects the quality of life. Objective tinnitus accounts for only 5% and has various aetiologies both non-otological and otological which include both non vascular and vascular. Vascular malformations like dural arteriovenous fistulas (DAVFs) constitute about 10% of objective tinnitus and hence are of academic interest to an otolaryngologist due to their rarity. We present one such case. A 26-year-old female presented to the department of ENT with chief complaints of a left pulsatile tinnitus of 2 months duration. A detailed clinical examination revealed no abnormality. A pure tone audiometry (PTA) was then done which once again showed hearing within normal limits. Given the clinical persistence of the symptom which was affecting her daily activities, further investigation of magnetic resonance imaging (MRI) brain was done. A suspicion of a dural arterio-venous fistula in the transverse sinus further warranted an arteriography which showed a low grade DAVF at the level of the left sigmoid sinus. DAVFs, although infrequent, constitute a treatable cause of tinnitus and hence should be considered as a possible diagnosis in all patients with pulsatile tinnitus, especially if it is unilateral. We also carried out a review of the current medical and surgical management in an attempt to better understand this rare yet intriguing condition.</p><p><strong> </strong></p>
Energy poverty in the świętokrzyskie voivodeship during the Covid-19 pandemic - In the context of the cumulative causation theory
Authors: Chojnacka Katarzyna J. 
Published: February 2022

Purpose of the study: The purpose of this article is to answer the question: does changing the socioeconomic situation alter the households’ condition and energy poverty level in a noticeable manner in the region? (with particular emphasis on the COVID-19 pandemic period).
Methodology: An inherent aspect of poverty is the limitation of the broadly defined development opportunities, both on economic, political, and social levels. Since economic poverty co-occurs with the phenomenon of energy poverty in households, the author posited the following thesis: there is a relationship between energy poverty and economic situation of households and health of its members in the region. The analysis will be based on: a study of household budgets, social diagnosis and available reports on energy poverty, and supplemented by an interpretation of an original survey conducted in the Świętokrzyskie voivodeship (conducted in mid-2021 for the previous two years).
Main Findings: Effectively combating energy poverty in the country and in a specific area (including the voivodeship) requires adequate recognition of the situation and identification of the people or households affected. The multifaceted nature of the phenomenon does not make it easy to choose which of the known indicators should be analyzed first. Moreover, its consequences vary as well. More details you will see at the conclusion.
Applications of the study: The article presents the phenomenon of energy poverty accompanying both social and economic life (the phenomenon of poverty should be considered multidimensionally). The social and health costs of energy poverty were emphasized. The content of the article can be useful for a wide group of recipients interested in the subject under research. Besides, this research is expected to be applied in Jan Kochanowski University during practical meetings with students.
Novelty/Originality of the study: The COVID-19 pandemic is having a noticeable impact on society and its members, individual markets, and the economy as a whole. Undeniably we have found ourselves in a difficult situation where numerous concepts are beginning to take on a deeper meaning. This includes energy poverty. In addition, there is no comprehensive research on the topic described in the title (for the Świętokrzyskie voivodeship) and the article tries to fill this gap. The article can inspire further research and inquiry in the field of it.
PENGARUH KOMUNIKASI INTERPERSONAL, KOMPENSASI KERJA, DAN MOTIVASI KERJA TERHADAP KINERJA GURU [THE EFFECT OF INTERPERSONAL COMMUNICATION, JOB COMPENSATION, AND JOB MOTIVATION ON TEACHER PERFORMANCE]
Authors: Purwaningratri Maria Arika 
Published: February 2022

<div><p class="1eAbstract-text"><em>Teacher performance is one of the most important things that shows that the learning process is running well. The learning process is the way to achieve the learning goals and foundation’s goals. Teacher performance can be affected by several things, such as interpersonal communication, </em><em>job </em><em>compensation, and job motivation. </em><em>Therefore, this research is going to find out the impact of interpersonal communication, job compensation, job motivation towards teachers’ performances. </em><em>This research used the quantitative approach and path analysis method. The subjects of this research were 30 teachers of SDS Saint Peter Kelapa Gading. The data were collected from 4 March 2016 until 11 March 2016. </em><em>The data were processed by the SmartPLS software to try out the research instrument and hypothesis. </em><em>Based on the data processing, there are five findings show that (1) interpersonal communication has a </em><em>positive</em><em> impact in teachers performances, (2) </em><em>job </em><em>compensation has a </em><em>positive</em><em> impact on teachers performances, (3) interpersonal communication has a </em><em>positive </em><em>impact on job motivation, (4) compensation has a </em><em>positive</em><em> impact on job motivation, (5) job motivation has a </em><em>positive</em><em> impact on teachers performances. In this research, interpersonal communication </em><em>is strongly influenced</em><em> toward the teachers’ performances.</em></p></div><p> </p>
Moderasi Beragama Berbasis Komunitas
Authors: Putrawan Agus Dedi , Gafur Abdul 
Published: February 2022

Moderasi beragama dengan keberterimaan tanpa syarat adalah cita-cita semua manusia di dunia ini, karena itu jejak DNA yang paling dasar dalam diri manusia adalah kedamaian. Maka dari itu manusia harus membenci kekerasan atas nama apapun. Manusia harus saling menghargai, menerima, menghormati dan menjunjung tinggi nilai-nilai kemanusiaan. Terciptanya gerakan moderasi beragama tidak bisa lepas dari jalan panjang meilitasi sistem sosial yang telah mengerah ke kehancuran sistem sosial. Berita-berita yang disodorkan terlevisi dan di beranda-beranda media sosial tentang korupsi, kolusi dan nepotisme, pemerkosaan, pencurian, perampokan, penyalahgunaan obat-obatan terlarang, kekerasan sosial dan kekerasan di dalam rumah tangga, bullying serta konflik di masyarakat karena perbedaan inter dan antar umat beragama. Tulisan ini mengasumsikan bahwa semua problem-problem sosial yang melibatkan individu, kelompok dan organisasi dalam masyarakat bermula dari perjumpaan yang tidak normal. Karena setiap saat manusia tidak dapat menghindari suatu perjumpaan dan menggunakan berbahasa maka perbaikannya dimulai di ranah itu. Mempertimbangkan bahwa perbaikan sistem sosial untuk menciptakan moderasi agama tidak boleh elitis yang memakan biaya mahal maka pendekatannya haruslan dengan pendekatan populis bengkelnya terdapat pada komunitas perjumpaan yang diberi nama Komunitas Sekolah Perjumpaan.. Sekolah perjumpaan merupakan teknologi sederhana namun sangatlah prinsipil yaitu bagaimana mengoptimalisasi perjumpaan dan mengedepankan tindakan berbahasa.
Upregulation of P2Y12 inhibits chondrocyte apoptosis in lumbar osteoarthritis through PI3K/AKT signaling pathway
Authors: Wu Guanyin , Xue Pengfei , Jin Hurich , Zhang Mo , Gui Chao , Bao Guofeng , Xu Guanhua , Jiang Jiawei , Zhang Jinlong , Cui Shengyu , Cui Zhiming , Sun Yuyu 
Published: February 2022

Abstract
BackgroundLumbar facet osteoarthritis (FJOA) is one of the major causes of severe low back pain and disability worldwide. However, the underlying mechanism of cartilage degeneration in FJOA remains unclear. MethodsThe rats were randomly divided into non-operation group (n=20) and operation group (n=10). In the operation group, MIA (Sigma, 200mg/mL) was injected into the right L4/5 facet process by blunt nanoneedle 26 (WPI, Sarasota, FL, USA) under the control of injection pump. The final injection volume was 5μL and the injection rate was 2μL/min. The facet joint was removed 4 weeks after surgery. After the operation, some samples were stored at 80°C until use. The right facet joints in each group were tested as follows. HE staining and iron red solid green staining were used to observe the degeneration of articular chondrocytes in rats. Immunohistochemistry and Western blot were used to observe the expression of P2Y12, MMP13, COL2 and other cartilage degeneration and apoptosis related indexes. Co-localization of P2Y12-Cleaved caspase-3 in apoptosis models was detected by dual-standard immunofluorescence staining. Apoptosis was detected by flow cytometry and TUNEL.ResultsThe expression of P2Y12 increased in OA cartilage tissue, and P2Y12 inhibited apoptosis. Knockdown of P2Y12 promotes IL-1β -induced apoptosis.ConclusionOur data suggest that P2Y12 has a chondroprotective effect on FJOA.
Epidemic inference through generative neural networks
Authors: Biazzo Indaco , Braunstein Alfredo , Dall'Asta Luca , Mazza Fabio 
Published: February 2022

Abstract
Reconstructing missing information in epidemic spreading on contact networks can be essential in prevention and containment strategies. For instance, identifying and warning infective but asymptomatic individuals (e.g., manual contact tracing) helped contain outbreaks in the COVID-19 pandemic.
The number of possible epidemic cascades typically grows exponentially with the number of individuals involved. The challenge posed by inference problems in the epidemics processes originates from the difficulty of identifying the almost negligible subset of those compatible with the evidence (for instance, medical tests).
Here we present a new generative neural networks framework that can sample the most probable infection cascades compatible with observations. Moreover, the framework can infer the parameters governing the spreading of infections.
The proposed method obtains better or comparable results with existing methods on the patient zero problem, risk assessment, and inference of infectious parameters in synthetic and real case scenarios like spreading infections in workplaces and hospitals.
The outcome of intravenous and inhalation anesthesia after pancreatic cancer resection: a retrospective study
Authors: Wang Yu , Ren Jie , Wang Junli , Chen Jingwen , Ma Yue , Yang Yutong , Wei Ming , Wang Liping 
Published: February 2022

Abstract
Background: Different types of anesthesia may affect cancer patient’s outcomes, we compared the overall survival (OS) and disease-free survival (DFS) of patients with pancreatic cancer under total intravenous and inhalation anesthesia.Methods: The authors collected the electronic medical records of patients who had accepted at a pancreatectomy from January 1, 2010 to December 31, 2016. Patients respectively received total intravenous anesthesia (TIVA) or inhalational anesthesia (INHA). Stabilized inverse probability of treatment weighting (SIPTW)was used to minimize differences. Kaplan-Meier survival was established to analyze the influence of sort of anesthesia on disease-free and overall survival. We compare the effects of each sort of anesthesia on cancer recurrence or metastasis and all-cause mortality.Results: A total of 463 patients who had undergone pancreatic cancer resection were collected in this study, of which 442 patients were available (TIVA group, n=323, INHA group, n=119). After SIPTW there were no significant differences between the two groups in disease-free survival (hazard ratio, 1.00, 95%CI, 0.79 to 1.27, P=0.995) or overall survival (hazard ratio, 1.10, 95%CI, 0.86 to 1.41, P=0.433).Conclusions: In conclusion, the present study showed no significant difference in overall survival and disease-free survival between total intravenous anesthesia and volatile anesthesia.
First-Born Children’s Temperament And Psychological Adaptation: The Mediating Effect Of Parenting Style
Authors: Qian Guoying , Yang Sijie , Li Ruonan , Dou Gang 
Published: February 2022

Abstract
Chinese first-born children need to learn how to get along with their siblings after the implementation of the universal two-child policy in 2016. We investigated the relationships between temperament, parenting style, and psychological adjustment among firstborns. A total of 524 Chinese children completed the Temperament, Parenting Style, and First-Born Behavior Questionnaires. The results indicated that (1) children’s temperament subscales were significantly related to parenting style subscales and psychological adaptation. Moreover, the parenting style subscales were significantly related to psychological adaptation, and (2) authoritarian parenting partially mediated the relationship between approach or withdrawal and psychological adjustment.
Microplastics Derived From Disposable Greenhouse Plastic Films and Irrigation Pipes: A Case Study From Turkey
Authors: Gündoğdu Rezan , Önder Derya , Gündoğdu Sedat , Gwinnett Claire 
Published: February 2022

Abstract
Plastics are ubiquitous. It has been used in human activities, from agriculture to packaging, infrastructure, and health. The wide range of usage makes plastics an omnipresent pollutant in the environment. Microplastics (MPs) are one of the most concerning environmental problems. This study investigated the abundance and type of MPs in agricultural soil in the Adana/Karataş region in Turkey, where disposable low tunnel greenhouse plastic films and irrigation pipes were in use. For this purpose, one kg of soil samples from the top 5 cm (from the surface) was taken from 10 different sampling locations. An average of 11.13 ± 2.31 MPs/kg of microplastic was found in the soil samples. The highest amount of microplastics was seen at the Bahçe-4 location with 32.0 ± 14.36 MPs/kg and the lowest amount of microplastics at the Karataş-1 location with 0.3 ± 0.3 MPs/kg. The average size of microplastics was found to be 3.28 ± 0.08 mm. The average microplastics originating from greenhouse cover plastics was 3.29 ± 0.09 mm, and from disposable irrigation pipes was 3.17 ± 0.22 mm. It was determined that the amount of microplastics decreased in the soil where used plastics were removed after usage. As a result, it has been determined that a significant amount of microplastic pollution remains in soil due to plastics used in agricultural areas.
An empirical comparison between polygenic risk scores and machine learning for case/control classification
Authors: Muneeb Muhammad , Feng Samuel , Henschel Andreas 
Published: February 2022

Abstract
BackgroundWe compared the procedure to calculate polygenic risk scores and machine learning for simulated data, devised a way to compare machine learning results with PRS, and highlighted the required files formats for PRS calculation and machine learning model training. For PRS calculation, we used three tools: Plink, PRSice, and Lassosum, and for the machine learning algorithm, we used artificial neural networks. ResultsBased on our survey, we cannot say machine learning is better or polygenic risk scores because it depends on the phenotype under consideration. The average classification AUC of PRSice, Plink, Lassosum, and Machine learning was 0.27, 0.3, 0.35, and 0.87 on simulated data. ConclusionThis article presents the comparison method in an automated way, ultimately assisting in various analyses. For instance, datasets with different heritability or genetic variations can be generated, and the effect on machine learning algorithms' accuracy and PRS's accuracy can be studied. Such analyses may require the generation of multiple datasets, calculation of PRS, and training machine learning model, which can be done quickly using the code segments and scripts provided in this manuscript. Apart from that, we compared the steps of PRS calculation with machine learning and found some steps are optional in machine learning.
Identification of microRNAs associated with heart failure with reduced ejection fraction
Authors: Li Xinli , Zhu Qingqing , Chen Mengli , Cheang Iokfai , Shi Mengsha , Zhang Ting , Gao Rongrong , Yao Wenming 
Published: February 2022

Abstract
Heart failure with reduced ejection fraction (HFrEF) is a complex disease with high mortality. The identification of new biomarkers and regulatory mechanisms for heart failure (HF) remains an important task. The crucial role of miRNAs in regulating the pathophysiological processes of HF has continuously been explored. Notably, the miRNA profiles from cardiac tissue and blood of patients with HFrEF were collected from the Gene Expression Omnibus (GEO) database in this study. After screening the data, two miRNAs (hsa-miR-216a and hsa-miR-217) with the highest cross-validation expression in tissues and blood and one miRNA (hsa-miR-208a) with the highest cross-validation expression in blood were identified. The miRNA-mRNA target gene interaction network and the enrichment analysis of the gene ontology (GO) and Kyoto Encyclopedia of Genomes (KEGG) pathways of differentially expressed miRNAs and target genes showed multiple signaling pathways with specific genes. The consistent expression of miR-217 in myocardial tissue and blood in HFrEF patients and mouse models demonstrates its reliability and repeatability in different etiologies, which will further deepen the understanding of miRNA as a potential biomarker and therapeutic target for heart failure.
The analysis of the impact of bone cement leakage through the endplate on the prognosis of patients after PKP on intervertebral disc
Authors: Qian Zhong-lai , Hua Xi , Lv Nan-ning , Deng Lei , Zhang Jun-Xin 
Published: February 2022

Abstract
Background:There is a high incidence in the elderly who come down with osteoporotic vertebral compression fracture (OVCF) and percutaneous kyphoplasty (PKP) is an effective solution which can relieve pain quickly. Previous studies have shown that both the volume and the distribution of bone cement filling are related to the clinical outcome after PKP surgery. However, the influence of bone cement leakage through the endplate after PKP on intervertebral disc remains to be explained. Methods:118 patients with single level OVCF operated by PKP were retrospectively reviewed from 2015 to 2020. These patients were grouped according to the degree of bone cement leakage. Group A: Bone cement leakage involving one endplate relative to the intervertebral disc. Group B: Bone cement leakage involving one endplate and the adjacent disc. Group C: Bone cement leakage involving both endplates of the intervertebral disc. The following variables were reviewed: gender, age, BMI, BMD and surgical parameters including cement volume (CV), Oswestry Disability Index (ODI), Visual analogue Scale (VAS), Anterior vertebral height ration (AVHR), Local kyphotic angle (LKA), Intervertebral space height (ISH) and the incidence of complications.Results:Compared with the preoperative for all groups, the VAS, ODI, AVHR, LKA and ISH were improved significantly after PKP. There is no significant difference among groups in AVHR and LKA (P> 0.05). Compared with preoperative levels, there was a significant reduction in fracture perivertebral pain in all groups after the surgery, but at the last follow-up, the VAS of Group C were worser than other groups (3.28±0.29 vs. 2.55±0.67vs. 1.73±0.51, P <0.05) and the ODI of Group C were also worser than other groups (44.46±6.65 vs. 35.77±6.33 vs. 29.80±5.96, P <0.05). At the last follow-up, the ISH of group C was worser than group B and group C (4.04±0.38 vs. 4.63±0.27 vs. 5.19±0.34, P <0.05). The complications including the adjacent vertebral fracture (AVF) and backache of group A was (1/39, 2.5%), that of group B was (6/33, 15.4%) and that of group C was (17/22, 42.5%). The incidence of complications in the group C was significantly higher than that in the other groups (P＜0.05). Conclusions:As the area of bone cement leaking from one endplate to another endplate of the intervertebral disc increases, there is no significant difference in the short-term effect after surgery, but the patient's long-term postoperative efficacy becomes worse. The incidence of AVF and back pain of adjacent vertebral bodies increases. It even aggravated the degeneration of the intervertebral disc and the symptoms of discogenic neuralgia appeared.