bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extensional Setting of Hainan Island in Mesoproterozoic: Evidence from Granitic Intrusions in the Baoban Group
Authors: LIU Yuheng , MAO Jingwen , QIU Kunfeng , HU Jun , WANG Lei , XU Deming 
Published: February 2022

AbstractThe Mesoproterozoic Baoban Group is the oldest basement in Hainan Island and has played an important role in Columbia (Nuna) supercontinent reconstructions. The Mesoproterozoic granitic intrusions in the Baoban Group are the most widely‐exposed Precambrian magmatic rocks and are the key to understanding the tectonic settings of Hainan Island and its relationship with the South China Block and the Columbia supercontinent. New LA‐ICP‐MS zircon U‐Pb dating on three mylonitic granite samples from the Tuwaishan and Baoban areas yield ages ranging from 1447 Ma to 1437 Ma, representing the absolute timing of the emplacement of the granitic intrusions. Combined with previously published geochronological data for rocks from the Baoban Group and regional mafic intrusions, it is concluded that the Baoban Group formed at 1460–1430 Ma, coeval with the emplacement of the granitic and mafic intrusions. New in‐situ zircon Lu‐Hf isotope analyses for the three mylonitic granite samples yielded positive ∊Hf(t) values, ranging from +0.49 to +8.27, with model ages () ranging from 2181 Ma to 1687 Ma, suggesting that the granitic intrusions originated from a mixed source of Paleoproterozoic crust with juvenile crust. New zircon trace element data show characteristics of high Th/U values of 0.24–1.50, steep slopes from LREE to HREE and negative Pr, Eu anomalies with positive Ce, Sm anomalies, representing typical magmatic zircons formed in continental crust. Compared with available magmatic and detrital zircon ages from Precambrian rocks in the Cathaysia Block, Yangtze Block and western Laurentia, it is inferred that Hainan Island was separated from both the Cathaysia Block and the Yangtze Block, instead being connected with western Laurentia in the Columbia supercontinent. Considering the decreasing tendency of basin deposition time along the western margin of Laurentia, it is proposed that Hainan Island was located to the north or northwest of the Belt‐Purcell Supergroup, along the western margin of Laurentia, during the breakup of the Columbia supercontinent.
A New Family of Galeaspids (Jawless Stem‐Gnathostomata) from the Early Silurian of Chongqing, Southwestern China
Authors: CHEN Yang , GAI Zhikun , LI Qiang , WANG Jianhua , PENG Lijian , WEI Guangbiao , ZHU Min 
Published: February 2022

AbstractA new genus and species of agnathan Eugaleaspidiformes (Galeaspida), Yongdongaspis littoralis gen. et sp. nov., is described from the Llandovery (lower Silurian) Huixingshao Formation at Yongdong Town, Xiushan County, Chongqing, southwestern China. This new Telychian taxon morphologically exhibits some transitional states between Sinogaleaspidae and a cluster of higher eugaleaspidiforms containing Tridensaspidae, Eugaleaspidae, Yunnanogaleaspis, and Nochelaspis, which we term here as the ‘eugaleaspid cluster'. Phylogenetic analysis of an extended character matrix of Galeaspida reveals Yongdongaspis, on which Yongdongaspidae fam. nov. is erected, as the sister taxon of this ‘eugaleaspid cluster', supported by two synapomorphies, the presence of one median transverse canal, and two lateral transverse canals leaving from the infraorbital canal. As the first fish described from the Llandovery Huixingshao Formation in Chongqing, Yongdongaspis provides new fossil evidence for the subdivision and correlation of the Upper Red Beds in South China.
Pharmacokinetics of alectinib and its metabolite M4 in a patient with advanced lung adenocarcinoma undergoing hemodialysis: A case report
Authors: Park Ji Eun , Yoon Young‐Ran , Kim Chang Ho , Lee Jaehee 
Published: February 2022

AbstractThis study presents the first detailed pharmacokinetic data of alectinib and its metabolite M4 in a patient with anaplastic lymphoma kinase (ALK)‐rearranged lung adenocarcinoma undergoing hemodialysis. When the patient was administered a daily 300 mg bid dose of alectinib, the maximal observed plasma concentration (Cmax) of alectinib and M4 were 638 and 82 ng/ml, respectively, at steady‐state (day 9). These pharmacokinetic data were similar to those previously reported in patients with normal organ function. The trough plasma concentration (Ctrough) of alectinib and M4 on the hemodialysis day were 562 and 66 ng/ml, respectively, identical to those on post‐hemodialysis day. He remains well and in partial remission 12 months after his diagnosis. We believe that alectinib is feasible and effective for patients with ALK‐rearranged non‐small cell lung cancer undergoing hemodialysis.
Coagulation abnormalities in patients with COVID‐19 on venovenous ECLS increased risk for technical complications and support times but had no impact on survival
Authors: Lehle Karla , Philipp Alois , Foltan Maik , Schettler Frank , Ritzka Markus , Müller Thomas , Lubnow Matthias 
Published: February 2022

AbstractBackgroundPatients with severe coronavirus disease‐19 (COVID‐19)‐associated acute respiratory distress on venovenous extracorporeal lung support (V‐V ECLS) showed a high incidence of vascular as well as ECLS‐related thrombotic complications. The latter may influence the outcome of the patients.MethodsThis is a retrospective monocentric study on prospectively collected data of technical complications including 69 adult COVID‐19 patients on V‐V ECLS (ECLS Registry, March 2020 until April 2021) without and with system exchanges. Alterations in ECLS‐specific data, hemolysis, coagulation, and hemostasis parameters were analyzed.ResultsEvery second COVID‐19 patient on V‐V ECLS developed technical complications. Optimized ECLS management at our ECLS center reduced cases of acute clot formation (pump head thrombosis, acute oxygenator thrombosis) (17%), and allowed early identification of progressive clotting processes (worsened gas transfer, coagulation disorder) (14%, 54%) with a significant overhang of hyperfibrinolysis (37%). Although COVID‐19 disease and technical complications caused the prolonged length of stay at the intensive care unit and ECLS support times, the proportion of successful weaning and survival rates were comparable with patients without system exchange.ConclusionThe survival of ECLS patients with COVID‐19 was independent of the requirement for system exchange due to technical‐induced coagulation disorders. Close monitoring for circuit clotting is mandatory in COVID‐19 patients and is one prerequisite for successful organ support in these difficult patients.
Does breastfeeding influence sleep? A longitudinal study across the first two postpartum years
Authors: Astbury Laura , Bennett Christie , Pinnington Donna M. , Bei Bei 
Published: February 2022

AbstractBackgroundThe association between breastfeeding and sleep of the gestational parent is poorly understood. This longitudinal study investigated how breastfeeding is associated with total nighttime sleep duration and sleep efficiency (percentage of total sleep time in bed) in nulliparous participants over the first two postpartum years.MethodsNulliparous participants (N = 155, Mage = 33.45, SDage = 3.50) self‐reported patterns of breastfeeding via telephone interviews and sleep via self‐report at 1.5, 3, 6, 12 and 24 months postpartum. Data were analyzed using mixed‐effects models, with breastfeeding variables as predictors and sleep variables as outcomes, controlling for relevant covariates.ResultsNeither the presence of breastfeeding nor the percentage of human milk in infants' total diets was significantly associated with participants' sleep duration or sleep quality (P‐values > 0.08). This finding held after controlling for the number of nighttime feeds (P‐values > 0.11). However, greater numbers of nighttime feeds, regardless of feeding content, were strongly associated with shorter sleep duration and poor sleep efficiency (P‐values < 0.05). On average, with each additional nighttime feed, nocturnal sleep duration decreased by 6.6‐8.4 minutes, and sleep efficiency decreased by 2.88%‐3.02%.ConclusionsData from this study showed that breastfeeding per se was not associated with shorter or poor nocturnal sleep, but the number of nighttime feeds was. Sharing nighttime infant care amongst different carers in the household could help reduce postpartum sleep disturbance and ameliorate its negative impact on wellbeing.
High-dose, high-frequency ustekinumab therapy for patients with severe hidradenitis suppurativa
Authors: Jiang Simon W. , Kwock Jeffery T. , Liu Beiyu , Petty Amy J. , Zhao Aaron T. , Green Cynthia L. , Jaleel Tarannum 
Published: February 2022

Abstract
In this case series, ustekinumab therapy demonstrated efficacy in some patients with severe hidradenitis suppurativa previously treated with adalimumab and/or infliximab. Larger prospective studies are needed to evaluate ustekinumab as a treatment option for recalcitrant hidradenitis suppurativa.
Interplay of environmental cues and wood density in the vegetative and reproductive phenology of seasonally dry tropical forest trees
Authors: Luna‐Nieves Adriana L. , González Edgar J. , Cortés‐Flores Jorge , Ibarra‐Manríquez Guillermo , Maldonado‐Romo Axel , Meave Jorge A. 
Published: February 2022

AbstractThe great phenological diversification characteristic of seasonally dry tropical forests (SDTF) suggests that these patterns result from a complex interplay between exogenous (e.g., climatic) and endogenous (e.g., morphological, physiological, anatomical) factors. Based on the well‐established relationships of wood density with water‐storing capacity and cavitation vulnerability in woody plants, we hypothesized differential vegetative and reproductive phenological responses to environmental cues for hardwood and softwood species. To test this hypothesis, we compared phenological patterns of pairs of conspecific populations of 10 species differing in wood density, occurring in two localities with slightly different climatic regimes, and evaluated the influence of three environmental variables (rainfall, photoperiod, and temperature) on them. Our results, based on the assessment of the overlap of the phenological curves of conspecific populations occurring in different sites and on linear modeling, showed different effects of the environmental factors on phenophase attributes, depending on wood density of the study species, thus supporting our hypothesis. Leaf out in softwood species took place in the dry season, they shed the foliage at the first signs of drought, and once leafless, they flowered and fruited shortly after. By contrast, hardwood species bore leaves and flowers in the rainy season, shed their leaves several months after the rain ceased, and produced fruits during the dry season. We conclude that the role of environmental variables in cueing growth and reproduction cycles in SDTF tree species is interrelated with their wood density, a key endogenous factor crucially linked to plant hydraulics in these water‐limited ecosystems.Abstract in Spanish is available with online material.
Clinical outcomes of a cohort of 271 patients with lung metastases from differentiated thyroid carcinoma
Authors: Maciel Joana , Cavaco Daniela , Silvestre Catarina , Simões Pereira Joana , Vilar Helena , Leite Valeriano 
Published: February 2022

AbstractContextLung is the most common site of distant metastases from differentiated thyroid carcinoma (DTC).ObjectiveTo investigate the outcomes of a cohort of patients with DTC and lung metastases (LM).MethodsA retrospective analysis of a cohort of 271 patients with LM was performed.ResultsThe female‐to‐male ratio was 1:1 and the median follow‐up time was 5.9 (1.1–38.4) years. Papillary thyroid carcinoma (PTC) was the most frequent type (83.4%), mainly the classic variant, followed by follicular thyroid carcinoma (FTC, 10.3%) and Hürthle cell carcinoma (HTC, 6.3%). The prevalence of PTC, FTC and HCC was different between the micronodular and macronodular LM groups [87.4%, 6.3% and 6.3% vs. 74.6%, 19.0% and 6.3%, respectively (p = .013)]. Only 5.0% of the patients had LM diagnosed after a period of remission. LM were submitted to radioactive iodine treatment (RAIT) in 84.5% (52.8% showed 131iodine avid metastases). Complete remission was only achieved in 12.2%. Micronodular disease and age <55 years at LM diagnosis were associated with a better prognosis (p < .05). We found no difference in survival between patients with LM treated or not with RAIT. However, in patients submitted to RAIT, there was a tendency for longer survival in the group of patients with 131I avid lesions. Conclusion: The classic variant of PTC was the most frequent histology found in LM of DTC. LM are rarely diagnosed in the follow‐up when complete remission is achieved after surgery and 131I. Younger age at LM diagnosis and a micronodular pattern are associated with a better prognosis.
What are predictors of impaired quality of life in patients with hypoparathyroidism?
Authors: Büttner Matthias , Krogh Dieter , Siggelkow Heide , Singer Susanne 
Published: February 2022

AbstractContextHypoparathyroidism (hypoPT) is a rare endocrine disorder. Little is known about what factors are associated with potential quality of life (QOL) impairments.DesignHypoPT patients at a minimum of 6 months' post diagnosis were invited to participate in an online survey through their treating physician or through self‐help organisationsMethodsImpairments of clinical importance in QOL were considered present if the score of the respective functioning scale of the European Organization for Research and Treatment of Cancer (EORTC) QLQ‐C30 exceeded a pre‐defined threshold. Symptom burden was assessed using the HPQ‐28. Multivariate logistic regression was used to identify factors associated with impairments in QOL.ResultsData were available for 264 hypoPT patients. Impairments of clinical importance in QOL were reported for 40.4% in role functioning (RF), 40.6% in social functioning (SF), 60.8% in physical functioning (PF), 65.5% in cognitive functioning (CF) and 76.0% in emotional functioning (EF). Higher odds for reporting impaired QOL were seen for higher symptom burden (for almost all domains) and for being unable to work (for PF, RF and SF). Surgery for thyroid cancer being the cause of hypoPT was associated with lower odds in PF for patients and in PF and CF for patients with surgery for other thyroid‐related diseases being the hypoPT cause.ConclusionsHypoPT needs to be recognised as a disease which might be associated with impaired QOL and affect daily living. Symptom management is crucial for improving QOL in hypoPT patients but socioeconomic factors like work‐ability need to be considered when treating hypoPT patients.
Incidental T1 stage medullary thyroid carcinoma: The effect of tumour diameter on prognosis and therapeutic implications
Authors: Gui Zhiqiang , Wang Zhihong , Xiang Jingzhe , Sun Wei , He Liang , Dong Wenwu , Huang Jiapeng , Zhang Dalin , Lv Chengzhou , Zhang Ting , Shao Liang , Zhang Ping , Zhang Hao 
Published: February 2022

AbstractObjectiveThe definition of the tumour diameter of micro‐medullary thyroid carcinoma (micro‐MTC) is insufficient. It is controversial to perform a completion thyroidectomy immediately for incidental T1 stage MTC.DesignWe used the Surveillance, Epidemiology and End Results (SEER) registry to retrospectively analyze all patients with T1 stage MTC diagnosed between 2004 and 2015. The tumour diameter 1.0 and 0.5 cm were used as the cut‐off points to group and analyze the differences of clinicopathological features. We analyzed the prognosis of patients with less than total thyroidectomy.MethodsThe disease‐specific survival was the main outcome. Survival was estimated with Kaplan–Meier curves and Cox regression models estimated hazard ratios for tumour characteristics.ResultsA total of 908 patients diagnosed with T1 stage MTC in the SEER database were included. Our study found that tumour diameter 1.0 cm is a key point affecting the prognosis of T1 stage MTC patients, although patients with tumour diameter ≤ 0.5 cm had a lower rate of lymph node metastasis and no distant metastasis. Cox proportional hazard multivariate analysis showed that distant metastasis was the only risk factor for survival in patients with T1 stage MTC. Kaplan–Meier survival analysis showed that, regardless of tumour diameter, there was no significant difference between less than total thyroidectomy and total thyroidectomy in T1 stage patients.ConclusionsFor incidental MTC with tumour diameter ≤ 1.0 cm and without distant metastasis, if there is no significant increase in serum calcitonin level after surgery and ret proto‐oncogene (RET) gene mutation is negative, it may be not necessary to perform completion thyroidectomy immediately.
Neural entrainment via perceptual inferences
Authors: Tavano Alessandro , Maess Burkhard , Poeppel David , Schröger Erich 
Published: February 2022

AbstractEntrainment depends on sequential neural phase reset by regular stimulus onset, a temporal parameter. Entraining to sequences of identical stimuli also entails stimulus feature predictability, but this component is not readily separable from temporal regularity. To test if spectral regularities concur with temporal regularities in determining the strength of auditory entrainment, we devised sound sequences that varied in conditional perceptual inferences based on deviant sound repetition probability: strong inference (100% repetition probability: If a deviant appears, then it will repeat), weak inference (75% repetition probability) and no inference (50%: A deviant may or may not repeat with equal probability). We recorded EEG data from 15 young human participants pre‐attentively listening to the experimental sound sequences delivered either isochronously or anisochronously (±20% jitter), at both delta (1.67 Hz) and theta (6.67 Hz) stimulation rates. Strong perceptual inferences significantly enhanced entrainment at either stimulation rate and determined positive correlations between precision in phase distribution at the onset of deviant trials and entrained power. We conclude that both spectral predictability and temporal regularity govern entrainment via neural phase control.
Cloning and expression analysis of ZjHSP18.9 from Zoysia japonica
Authors: Huang Zhi‐yong , Sun Xin‐bo , Zou Yao 
Published: February 2022

AbstractThe ZjHSP18.9 gene was isolated from Zoysiagrass by homologous cloning based on publicly available transcriptome database. Sequence alignment analysis revealed that ZjHSP18.9 protein contains a classic Hsp23/ACD domain. Phylogenetic analysis and subcellular localization prediction suggested that ZjHSP18.9 belongs to cytosolic class VI subfamily. The expression profiles of ZjHSP18.9 in leaf and root after abiotic stress or Abscisic Acid (ABA) treatment was investigated using quantitative real‐time polymerase chain reaction. The results showed that the expression level of ZjHSP18.9 in leaf was higher than that in root. The expression of ZjHSP18.9 was strongly induced by high temperature in leaf; the ZjHSP18.9 expression level was up‐regulated in both leaf and root by the treatment of low temperature, salt and heavy metal, while down‐regulated under the treatment of drought and ABA. The gene expression profiles indicated that ZjHSP18.9 may play an important role in Zoysiagrass response to environmental stress including extreme temperature, salinity, water deficiency and heavy metal through ABA dependent and/or independent pathway.
The COVID‐19 pandemic: The watershed moment for student mobility in Chinese universities?
Authors: Li Min , Ai Ni 
Published: February 2022

AbstractAs COVID‐19 drastically affects cross‐border mobility, virtual mobility emerges as a viable alternative to cope with the crisis. This article reports on the integrated findings of an exploratory sequential mixed methods design to understand benefits and challenges of virtual mobility at a Chinese university and future projection of outbound student mobility. The mixed methods design used in this study is characterized by an initial quantitative phase of data collection and analysis, followed by a phase of qualitative data collection and analysis, with a final phase of integration or linking of data from the two separate strands of data. The study suggests Chinese students appreciate the flexibility and economic advantages of virtual mobility but also express concerns on several limitations. Online mobility may be viewed as a complement or alternative for Chinese institutions when the COVID‐19 crisis is over. As Chinese universities are promoting internationalization at home, the number of virtual programmes available to Chinese students will surge. In this context, coupled with the stress of geopolitical instability, the growth in Chinese student mobility may be entering a period of contraction, which may exert profound impacts on a global scale.
Exploring an algorithm to harmonize International Obesity Task Force and World Health Organization child overweight and obesity prevalence rates
Authors: Cole Tim J. , Lobstein Tim 
Published: February 2022

SummaryBackgroundThe International Obesity Task Force (IOTF) and World Health Organization (WHO) body mass index (BMI) cut‐offs are widely used to assess child overweight, obesity and thinness prevalence, but the two references applied to the same children lead to different prevalence rates.ObjectivesTo develop an algorithm to harmonize prevalence rates based on the IOTF and WHO cut‐offs, to make them comparable.MethodsThe cut‐offs are defined as age‐sex‐specific BMI z‐scores, for example, WHO +1 SD for overweight. To convert an age‐sex‐specific prevalence rate based on reference cut‐off A to the corresponding prevalence based on reference cut‐off B, first back‐transform the z‐score cut‐offs and to age‐sex‐specific BMI cut‐offs, then transform the BMIs to z‐scores and using the opposite reference. These z‐scores together define the distance between the two cut‐offs as the z‐score difference . Prevalence in the target group based on cut‐off A is then transformed to a z‐score, adjusted up or down according to and back‐transformed, and this predicts prevalence based on cut‐off B. The algorithm's performance was tested on 74 groups of children from 14 European countries.ResultsThe algorithm performed well. The standard deviation (SD) of the difference between pairs of prevalence rates was 6.6% (n = 604), while the residual SD, the difference between observed and predicted prevalence, was 2.3%, meaning that the algorithm explained 88% of the baseline variance.ConclusionsThe algorithm goes some way to addressing the problem of harmonizing overweight and obesity prevalence rates for children aged 2–18.
Cannabis, cannabidiol and tetrahydrocannabinol in sport: an overview
Authors: Kennedy Michael 
Published: February 2022

AbstractThe World Anti‐Doping Agency now allows cannabidiol (CBD) to be taken in elite sport, but has retained all other cannabinoids on its banned list. This, together with liberalisation of cannabis laws, has led to an increasing interest in its use in sport. This includes commercial sponsorship of sporting events and highlights the need for accurate information to be readily available to athletes and their advisers. This narrative review confirms that CBD and tetrahydrocannabinol (THC) do not enhance performance. CBD possesses anti‐inflammatory and analgesic properties that have not been adequately evaluated in the area of sport. Some formulations of CBD contain THC or other cannabinoids that may result in a positive drug test.