bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety of cholecystectomy in patients under antithrombotic Drugs: A systematic review and meta-analysis
Authors: Shao Xiaolan , Cui Xiuhong 
Published: October 2022

Objective: This review aimed to assess evidence on the safety of cholecystectomy in patients under antithrombotic therapy.
Methods: PubMed, Embase, Science Direct, CENTRAL, and Google Scholar databases were searched from inception up to 20th January 2022 for studies comparing outcomes of patients undergoing cholecystectomy surgeries with or without concomitant antithrombotic therapy.
Results: Nine studies were included. Meta-analysis revealed that the use of antithrombotic medications had no statistically significant effect on intra-operative blood loss in patients undergoing cholecystectomy (MD: 82.31 95% CI: -283.38, 448 I2=98% p=0.66). However, incidence of blood transfusion (OR: 5.65 95% CI: 1.10, 28.86 I2=83% p=0.04) and bleeding complications (OR: 8.02 95% CI: 1.71, 37.58 I2 = 71% p=0.008) were significantly increased in patients under antithrombotic therapy. Pooled analysis indicated that cholecystectomy patients under antithrombotic are at an increased risk of conversion to open surgery (OR: 2.02 95% CI: 1.21, 3.36 I2=0% p=0.007). Meta-analysis revealed significantly shorter LOS in patients under antithrombotic (MD: -5.01 95% CI: -8.29, -1.73 I2=97% p=0.03).
Conclusion: Current evidence from a limited number of studies indicates that the use of antithrombotic may be associated with an increased risk of bleeding-related complications in patients undergoing cholecystectomies. Antithrombotic use may also increase the risk of conversion to open surgery in patients undergoing laparoscopic cholecystectomies.
doi: https://doi.org/10.12669/pjms.38.8.7032
How to cite this:Shao X, Cui X. Safety of cholecystectomy in patients under antithrombotic Drugs: A systematic review and meta-analysis. Pak J Med Sci. 2022;38(8):2365-2372. doi: https://doi.org/10.12669/pjms.38.8.7032
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
SPME-GC-HRTOF-MS dataset of fermented maize flour volatilome
Authors: Adebo Oluwafemi Ayodeji , Gbashi Sefater , Kewuyemi Yusuf Olamide , Sobowale Sunday Samuel , Adeboye Adedola Sulaiman , Njobeh Patrick Berka , Oyeyinka Samson Adeoye , Wilkin Jonathan D. , Chinma Chiemela Enyinnaya 
Published: October 2022

Background: The volatilome of fermented food products are essential metabolites that significantly contribute to such foods’ overall composition and sensorial quality. The dataset presented herein represents the volatilome of raw and fermented maize flour samples. Methods: Maize grains were milled and naturally fermented at 35°C into sourdough at different periods (24, 48 and 72 h) and, at each point, the profile of the volatiles was investigated. Samples at the different fermentation periods were analyzed using solid phase microextraction coupled with a gas chromatography-high resolution time of flight-mass spectrometry (SPME-GC-HRTOF-MS). Results: Data obtained were classified into different compound groups such as alcohols, aldehydes, aromatic compounds, esters, organic acids, terpenes, ketones, among others and their characteristics such as the retention time, observed mass, molecular formular, mean peak areas and mass spectra also presented. Conclusion: These datasets of fermented maize volatilome can be used as biomarkers for maize fermentation.
Hypertension and its risk factors among the Shabar tribe: A community-based cross-sectional study in Odisha, India
Authors: Chakrabarty Suman , Bharati Premananda 
Published: October 2022

In developing countries like India, the increasing trend of hypertension is one of the significant public health problems. In recent times, the Indian tribes are also experiencing a similar trend, which is rarely documented and less emphasized.
The objectives of the present study are to assess the prevalence of hypertension among the Shabar tribe and to understand the association with some selected biological, behavioural and socio-economic factors. The data were collected from 816 individuals (389 males and 427 females, aged 20 to 60 years) in the Khurda and Cuttack districts of Odisha. Conventional methodologies were used to collect the cross-sectional data of blood pressure and other parameters.
It was found that 9.2% of the respondents suffered from hypertension (SBP ≥ 140 and DBP ≥ 90 mmHg), and 12.3% had high normal blood pressure (SBP ≥ 130 and DBP ≥ 85 mmHg). The unadjusted odd ratios showed that the proportion of hypertension increased significantly as age increased. High normal blood pressure and hypertension were significantly higher in females and people who belonged to the high-income group and consumed more fat. The Shabar people who suffered from overweight and obesity, took extra salt during meals, smokers, smokeless tobacco chewers, and alcoholics were more vulnerable to hypertension and high blood pressure. Interestingly, the participants who perceived their fatty bodies and engaged in light activities were more likely to be hypertensive than their counterparts.
Shabar people residing in Odisha state have shown increasing frequencies of hypertension with advancing age. A significant co-occurrence of higher body mass index (BMI), fewer physical activities, increased fat consumption, and changing habits relating behaviour to hypertension may be designated as potential risk factors.
Neurodegenerations are diseases of the present and the future
Authors: Górska Ewelina , Bogdan Sylwia , Gorodkiewicz Ewa , Hermanowicz Adam 
Published: October 2022

Neurodegenerations are diseases of the present and the future. As the human population grows, the number of people suffering from neurodegenerative diseases will increase. Neurodegenerations diseases are Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, spinocerebellar ataxia, spinal muscular ataxia), sporadic (amyotrophic lateral sclerosis) or infectious (prion disease). Nerve cells (neurons) can’t regenerate and therefore die under the influence of pathological factors. Neurodegenerations diseases can be serious or life-threatening. It depends on the type. Drags and treatments may help improve symptoms, relieve pain, and increase mobility.
From Perspective Maps to Epigraphical Projections
Authors: Friedlander Michael P. , Goodwin Ariel , Hoheisel Tim 
Published: October 2022

The projection onto the epigraph or a level set of a closed proper convex function can be achieved by finding a root of a scalar equation that involves the proximal operator as a function of the proximal parameter. This paper develops the variational analysis of this scalar equation. The approach is based on a study of the variational-analytic properties of general convex optimization problems that are (partial) infimal projections of the sum of the function in question and the perspective map of a convex kernel. When the kernel is the Euclidean norm squared, the solution map corresponds to the proximal map, and thus, the variational properties derived for the general case apply to the proximal case. Properties of the value function and the corresponding solution map—including local Lipschitz continuity, directional differentiability, and semismoothness—are derived. An SC1 optimization framework for computing epigraphical and level-set projections is, thus, established. Numerical experiments on one-norm projection illustrate the effectiveness of the approach as compared with specialized algorithms. Funding: This work was supported by Natural Sciences and Engineering Research Council of Canada (NSERC). M.P. Friedlander was supported by NSERC discovery grant [Grant RGPIN-2017-04461]. T. Hoheisel was supported by NSERC discovery grant [Grant RGPIN-2017-04035]. A. Goodwin’s work was partially supported by an NSERC summer research stipend.
Effects of the FIFA 11+ and a modified warm-up programme on injury prevention and performance improvement among youth male football players
Authors: Asgari Mojtaba , Alizadeh Mohammad Hossein , Shahrbanian Shahnaz , Nolte Kevin , Jaitner Thomas 
Published: October 2022

Introduction
The effects of the FIFA11+ programme (the 11+) on ankle and groin injuries and performance have remained questionable. The latter, particularly, has potentially reduced the implementation rate and applicability of the programme. This study aimed to evaluate the mid-to-long-term effects of the 11+ and a modified programme including football-specific exercises on injury prevention and performance improvement.

Materials and methods
Three teams of the Iranian Youth League (division two) volunteered to participate in this study and were randomly assigned to two intervention groups (F11+; n = 29, M11+; n = 31) and a control group (n = 30). The F11+ followed the FIFA 11+ programme, whereas the M11+ performed modified exercises three times weekly as a warm-up protocol before training and competition through a football season. The control group carried out its routine warm-ups, including joggings, basic football drills, and static stretches, while having no injury prevention approaches. Lower extremity injuries, as well as exposure time for each player, were recorded. The football-specific performance was assessed using the Illinois Agility and Slalom Dribbling tests. ANOVA, Fisher Freeman Halton, and chi-square tests were used to analyze the data.

Results
Injury incidences differed significantly between groups (p = 0.02, C = 0.40), with M11+ reporting the lowest incidence. Significant differences between the pre- and posttest as well as differences between the groups for development over time were revealed for the Illinois agility and dribbling speed (p≤0.01). Both performance tests demonstrated a large time effect, as the effect sizes for time in agility and dribbling speed were 0.74 (CI = [0.66; 0.79]) and 0.86 (CI = [0.79; 0.87]), respectively. The effect size for the interaction can be categorized as medium, with 0.38 (CI = [0.25; 0.49]) for agility and 0.52 (CI = [0.40; 0.61]) for dribbling speed. M11+ showed the largest improvement in both.

Discussion
Mid-to-long-term application of a structured dynamic warm-up that integrates injury prevention and performance approaches may lower injury incidences and improve youth subelite players’ performance. Although additional studies with larger samples are needed to prove the results of the current study, the amateur clubs/teams could integrate such twofold dynamic warm up into their routine training plan and benefit its advantages on injury prevention and performance improvement.
Perceived empowerment and the impact of negative effects of the COVID-19 pandemic on the quality of life of persons with severe mental illness
Authors: Mueller-Stierlin Annabel Sandra , Meixner Friedrich , Lehle Jutta , Kohlmann Anne , Schumacher Mara , Woehler Stefanie , Haensel Anke , Reuter Sabrina , Herder Katrin , Bias Nicole , Becker Thomas , Kilian Reinhold 
Published: October 2022

Purpose
Beyond its direct effects on physical health the COVID-19 pandemic has been shown to have negative effects on the living situation of people with severe mental illness (SMI). To date, there has been little research on resilience factors preventing people with SMI from experiencing negative effects of the COVID-19 pandemic.
The objective of this study was to investigate the role of perceived empowerment (PE) as a resilience factor, preventing people with SMI from experiencing negative effects of the COVID-19 pandemic on daily living.

Methods
We investigated negative effects of the COVID-19 pandemic on daily living in 931 persons with SMI at two times within six month between June 2020 and Mai 2021. To take into account the longitudinal structure of the data we applied mixed effects regression analyses and longitudinal path models.

Results
A majority of participants experienced negative effects of the COVID-19 pandemic on several dimensions of daily living. Negative effects increased with rising levels of illness-related impairment but decreased as the level of PE rose. While negative effects of the COVID-19 pandemic at follow-up were negatively associated with overall subjective quality of life baseline, PE was negatively associated with the negative impact of the pandemic and positively with quality of life.

Conclusion
Patients with SMI need support to reduce negative effects of the COVID-19 pandemic on their quality of life. The promotion of PE could help strengthen resilience in this target group.

Trial registration
German Clinical Trial Register, DRKS00019086, registered on 3 January 2020. (https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00019086).
Three-dimensional fractal dimension and lacunarity features may noninvasively predict TERT promoter mutation status in grade 2 meningiomas
Authors: Won So Yeon , Lee Jun Ho , Lee Narae , Park Yae Won , Ahn Sung Soo , Kim Jinna , Chang Jong Hee , Kim Se Hoon , Lee Seung-Koo 
Published: October 2022

Purpose
The 2021 World Health Organization classification includes telomerase reverse transcriptase promoter (TERTp) mutation status as a factor for differentiating meningioma grades. Therefore, preoperative prediction of TERTp mutation may assist in clinical decision making. However, no previous study has applied fractal analysis for TERTp mutation status prediction in meningiomas. The purpose of this study was to assess the utility of three-dimensional (3D) fractal analysis for predicting the TERTp mutation status in grade 2 meningiomas.

Methods
Forty-eight patients with surgically confirmed grade 2 meningiomas (41 TERTp-wildtype and 7 TERTp-mutant) were included. 3D fractal dimension (FD) and lacunarity values were extracted from the fractal analysis. A predictive model combining clinical, conventional, and fractal parameters was built using logistic regression analysis. Receiver operating characteristic curve analysis was used to assess the ability of the model to predict TERTp mutation status.

Results
Patients with TERTp-mutant grade 2 meningiomas were older (P = 0.029) and had higher 3D FD (P = 0.026) and lacunarity (P = 0.004) values than patients with TERTp-wildtype grade 2 meningiomas. On multivariable logistic analysis, higher 3D FD values (odds ratio = 32.50, P = 0.039) and higher 3D lacunarity values (odds ratio = 20.54, P = 0.014) were significant predictors of TERTp mutation status. The area under the curve, accuracy, sensitivity, and specificity of the multivariable model were 0.84 (95% confidence interval 0.71–0.93), 83.3%, 71.4%, and 85.4%, respectively.

Conclusion
3D FD and lacunarity may be useful imaging biomarkers for predicting TERTp mutation status in grade 2 meningiomas.
Comprehensive analysis of the immune implication of FABP4 in colon adenocarcinoma
Authors: Wu Dabin , Xiang Ling , Peng Linglong , Gu Haitao , Tang Yunhao , Luo Haoyun , Liu Hang , Wang Yaxu 
Published: October 2022

Background
Fatty acid-binding protein 4 (FABP4) has been reported to be associated with tumor progress and poor prognosis in various cancers. However, the relationship between FABP4 expression and tumor immunity in colon adenocarcinoma (COAD) is still poorly understood.

Methods
FABP4 mRNA expression was analyzed using The Cancer Genome Atlas (TCGA)-COAD data. FABP4 protein staining was performed by immunohistochemistry (IHC) staining in our 10 paired COAD samples and corresponding adjacent noncancerous tissues. The association between FABP4 and immune cell infiltration was evaluated by Tumor Immune Estimation Resource (TIMER) database. FABP4 coexpressed genes were identified based on Cancer Cell Line Encyclopedia (CCLE) database, which were employed for further enrichment analysis. FABP4 related immunomodulators was identified by Tumor and Immune System Interaction Database (TISIDB) database, and a prognostic risk signature was constructed based on FABP4-related immunomodulators using stepwise Cox regression analysis. A nomogram consists of FABP4 related immunomodulators signature and clinical parameters was developed to predict the overall survival (OS).

Results
In TCGA data, we found that the decreased FABP4 mRNA expression in COAD samples compared with normal samples, and low FABP4 mRNA expression was associated with B cells, CD4+ T cells, CD8+ T cells, myeloid dendritic cells, macrophages, and neutrophils. In our 10 paired samples, the protein levels of COAD were lower in all COAD tissues than in their adjacent noncancerous tissues. Functional enrichment analysis revealed that FABP4 coexpressed genes were mostly enriched in immune-related pathways. Based on 54 FABP4-related immunomodulators, a 2-gene FABP4-related prognostic risk signature was developed, and the signature stratified the patients into the high-risk and low-risk groups with statistically different survival outcomes. The Nomogram consists of the prognostic signature and clinical parameters had a certain predictability for prognosis of COAD patients.

Conclusion
These findings suggest that FABP4 is associated with 2-gene immune signature which also correlate with the prognosis of COAD patients.
Ultrasonography can replace chest X-rays in the postoperative care of thoracic surgical patients
Authors: J. Jakobson Daniel , Cohen Ornit , Cherniavsky Evgenia , Batumsky Moris , Fuchs Lior , Yellin Alon 
Published: October 2022

Objectives
Lung ultrasound accurately identifies pulmonary and pleural pathologies. Presently it has not been accepted as a routine examination in the postoperative follow-up of thoracic surgical patients. The present study aimed to compare thoracic ultrasonography with chest X-ray for detecting and clinical relevance of pneumothorax, pleural effusion, and lung consolidation and determine whether ultrasonography could replace chest X-ray as the standard examination after surgery.

Methods
In this blinded, prospective, single-center study, lung ultrasound images were obtained within 2 hours of post-operative routine chest X-ray. A severity score was given to each examination in each technique. Lung ultrasound and chest X-ray results were compared by three methods: absolute comparison of normal to abnormal, the degree of pathology, and the clinical findings’ relevance.

Results
Eighty patients were enrolled from 2013 to 2017, and 215 ultrasonography images were obtained. For pneumothorax, the precise overlap was found in 129/180 (72%) images. In 24% of examinations, X-ray missed ultrasonography findings. There was an agreement between studies in 80/212 (38%) images for pleural effusion. 60% of pleural effusions were missed by chest X-ray and detected by ultrasonography, and only 2.4% were missed by ultrasound, all very small. Clinically relevant fluid accumulation found a precise match in 80%, and 20% were found only by lung ultrasound. For lung consolidation, a 100% overlap was found with both methods.

Conclusions
Our results suggest that lung ultrasound may replace chest X-ray as the standard examination in the postoperative care of patients undergoing thoracic surgical procedures.
Risk factors for venous thromboembolism following fractures isolated to the foot and ankle fracture
Authors: Gouzoulis Michael J. , Joo Peter Y. , Kammien Alexander J. , McLaughlin William M. , Yoo Brad , Grauer Jonathan N. 
Published: October 2022

Objective
Venous thromboembolism (VTE) is an uncommon, but potentially morbid, complication following foot and ankle fractures. Current standard is to not administer thromboprophylaxis to patients with such injuries. Nonetheless, patient and fracture factors might affect this risk/benefit consideration. The goal of this study was to determine what patients are most at risk.

Methods
The M53Ortho Pearldiver database was used to identify patients with fractures isolated to the foot and ankle that were treated non-operatively or operatively. Patients with pilon, other appendicular fractures remote from the foot and ankle, and other traumatic injuries were excluded. The 90-day occurrence of VTE was identified based on codes for deep vein thrombosis or pulmonary embolism. Characteristics of those patients who did and did not have VTEs were compared using chi-square analyses. Multivariate logistical regression was then performed to determined factors independently associated with VTE. Finally, timing of VTE relative to fracture was analyzed.

Results
A total of 298,886 patients with isolated foot or ankle fractures were identified, of which 1,661 (0.56%) had VTE in the 90 days following fracture. In terms of timing, 27.3% occurred in the first week, and 49.8% occurred in the first three weeks. Independent risk factors for VTE included (in decreasing order):prior VTE (odd ratio [OR] = 25.44), factor V Leiden (OR = 24.34), active cancer (OR = 1.84), specific fracture relative to metatarsal fracture (multiple fractures [OR: 1.51], ankle fracture [OR = 1.51], and calcaneus fracture [OR = 1.24]), surgical treatment (OR = 1.41), male sex (OR = 1.19), greater Elixhauser index (OR = 1.05), and increasing age (OR:1.05 per decade) (p<0.05 for each).

Conclusions
The present study found that, although only 0.56% of isolated foot and ankle fractures had a VTE within ninety days. Defined risk factors, such as Factor V Leiden, prior VTE, surgical treatment, active cancer, specific fracture patterns, and surgical treatment significantly affected the odds of their occurrence.
Prevalence of depression in Uganda: A systematic review and meta-analysis
Authors: Kaggwa Mark Mohan , Najjuka Sarah Maria , Bongomin Felix , Mamun Mohammed A. , Griffiths Mark D. 
Published: October 2022

BackgroundDepression is one of the most studied mental health disorders, with varying prevalence rates reported across study populations in Uganda. A systematic review and meta-analysis was carried out to determine the pooled prevalence of depression and the prevalence of depression across different study populations in the country.MethodsPapers for the review were retrieved fromPubMed,Scopus,PsycINFO,African Journal OnLine, andGoogle Scholardatabases. All included papers were observational studies regarding depression prevalence in Uganda, published before September 2021. The Joanna Briggs Institute Checklist for Prevalence Studies was used to evaluate the risk of bias and quality of the included papers, and depression pooled prevalence was determined using a random-effects meta-analysis.ResultsA total of 127 studies comprising 123,859 individuals were identified. Most studies were conducted among individuals living with HIV (n= 43; 33.9%), and the most frequently used instrument for assessing depression was the Depression sub-section of the Hopkins Symptom Checklist (n= 34). The pooled prevalence of depression was 30.2% (95% confidence interval [CI]: 26.7–34.1,I2= 99.80,p<0.001). The prevalence of depression was higher during the COVID-19 pandemic than during the pre-pandemic period (48.1% vs. 29.3%,p= 0.021). Refugees had the highest prevalence of depression (67.6%; eight studies), followed by war victims (36.0%; 12 studies), individuals living with HIV (28.2%; 43 studies), postpartum or pregnant mothers (26.9%; seven studies), university students (26.9%; four studies), children and adolescents (23.6%; 10 studies), and caregivers of patients (18.5%; six studies).LimitationSignificantly high levels of heterogeneity among the studies included.ConclusionAlmost one in three individuals in Uganda has depression, with the refugee population being disproportionately affected. Targeted models for depression screening and management across various populations across the country are recommended.Trial registrationProtocol registered with PROSPERO (CRD42022310122).