bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microperimetric evaluation in eyes with cuticular drusen
Authors: Lee Jung Hwa , Kong Mingui 
Published: April 2022

Abstract
Introduction: To determine microperimetric retinal sensitivity in patients with cuticular drusen and evaluate differences on retinal sensitivity according to cuticular drusen type on spectral domain optical coherence tomography (SD-OCT) scans. Methods: Thirty two eyes of 52 participants with cuticular drusen were recruited in this retrospective cross-sectional study. All subjects underwent ophthalmologic evaluations including best-corrected visual acuity (BCVA) assessment, SD-OCT, slit-lamp biomicroscopy, color fundus photography, fluorescein angiography, fundus autofluorescence, and mean retinal sensitivity (MRS) as measured by microperimetry, which was performed using 52 stimulus points. The division of patients into three groups was based on SD-OCT. The correlation between MRS and the mean deviation (MD) value was evaluated with linear regressions.Results: MRS was significantly different between cuticular drusen types (p<0.05). Generalized decreased MRS was detected more frequently in eyes with cuticular drusen type 2 (73.7%, 14/19) and 3 (85.7%, 18/21) compared to normal eyes. Retinal sensitivity was significantly correlated only with the MD value (p<0.001). There were no significant correlations with age, corrected visual acuity, pattern standard deviation, drusen occupying points, or cuticular drusen types.Conclusion: Our study showed that MRS decreased according to the type of cuticular drusen on SD-OCT. These visual function tests could be useful measurements, for cuticular drusen type.
The mechanism by which tertiary lymphoid structures in tumours affect prognosis and immunotherapy in patients with hepatocellular carcinoma
Authors: Li Jianhui , Nie Ye , Wu Wenlong , Lei Xinjun , Zhang Tianchen , Mao Zhenzhen , Wang Yanfang , Cao Zhuolin , Tao Kaishan , Song Wenjie 
Published: April 2022

Abstract
Background
Tertiary lymphoid structures (TLSs) are formed by the aggregation of tumour-infiltrating lymphocytes (TILs), which is driven by chemokines or cytokines in the tumour microenvironment. Studies have shown that TLSs are associated with good prognosis in patients with various solid tumours and can improve patient responses to immunotherapy. However, the role of TLSs in hepatocellular carcinoma (HCC) remains controversial, and the underlying molecular mechanism is unclear.
Methods
According to haematoxylin-eosin (HE) staining results, 150 HCC patients from Xijing Hospital were divided into TLS + and TLS- groups, and Kaplan–Meier (K-M) analysis was performed to assess their overall survival (OS) and recurrence-free survival (RFS). Spearman correlation analysis was used to calculate the correlation between LCK and TILs, and the molecular pathways of LCK regulating immunotherapy were clarified through enrichment analysis. Immune score was calculated based on the expression difference of LCK to evaluate the sensitivity of HCC patients to ICIs.
Results
The HE results showed that 61 (40.7%) of 150 HCC patients had TLSs, and 89 (59.3%) didn't. The K-M results showed that TLSs had no effect on the OS of HCC patients but significantly affected the RFS. Enrichment analysis showed that upregulation of LCK expression mainly regulated cytokine signalling pathway, the chemokine signalling pathway and T cell activation. Immune score showed that HCC patients with high expression of LCK had higher sensitivity to ICIs.
Conclusion
LCK may regulate the sensitivity of HCC patients to ICIs by affecting the related pathways of TLSs formation to improve the prognosis of patients.
Clinical predictors of the rapid progression and revascularization of coronary non-target lesions: a serial angiographic study
Authors: Wang Juan , Xu Haobo , Yuan Jiansong , Guo Chao , Hu Fenghuan , Yang Weixian , Song Lei , Luo Xiaoliang , Liu Rong , Cui Jingang , Liu Shengwen , Chen Jilin , Qiao Shubin 
Published: April 2022

Abstract
Rapid progression of coronary no-target lesions is essential for the induction of future cardiovascular events. We aimed to investigate clinical predictors of rapid progression and revascularization of coronary non-target lesions. Consecutive patients who underwent two serial coronary angiographies were included. All coronary non-target lesions were recorded and evaluated at both procedures. A total of 1255 patients and 1670 lesions were included. At the patient level, 239 (19%) had rapid progression and 186 (14.8%) underwent revascularization. The incidence of lesion revascularization and myocardial infarction was significantly higher in patients with rapid progression. In multivariable analyses, hypertension (hazards ratio [HR], 0.76; 95% confidence interval [CI], 0.58-1.00; P = 0.049), ST-segment elevation myocardial infarction (HR, 1.46; 95%CI, 1.03-2.07; P = 0.035), glycosylated hemoglobin (HR, 1.16; 95%CI, 1.01-1.33; P = 0.039) and lesion classification (B2/C versus A/B1) (HR, 1.73; 95%CI, 1.27-2.35; P = 0.001) were significant factors associated with rapid progression. The level of triglyceride (HR, 1.10; 95%CI, 1.00-1.20; P = 0.040) and lesion classification (B2/C versus A/B1) (HR, 1.53; 95%CI, 1.09-2.14; P = 0.014) were predictors of lesion revascularization. Clinicians should pay more attention to patients with these factors to prevent future cardiovascular events.
The prevalence of normal-weight obesity and its possible related dietary factors: A cross-sectional study of university employees of Iran
Authors: Eftekhari Mohammad Hassan , Kohanmoo Ali , Masoumi Seyed Jalil , Mohsenpour Mohammad Ali , Jamshidi Sanaz 
Published: April 2022

Abstract
Background: The aim of this study was to assess the prevalence of Normal-Weight Obesity (NWO) and some possible relationships with dietary factors in an Iranian population.Methods: A cross-sectional study was conducted on the participants of the Employees Health Cohort Study, Shiraz, Iran. Based on the anthropometric assessments, participants were categorized into three groups: Normal-weight Non-obese, NWO, and Overweight/Obese. NWO was defined as having normal body mass index (BMI) but high body fat; which was determined by waist circumference or percentage of body fat, using various cut-off points. Body fat % ≥ 25 for men and ≥35 for women, proposed by WHO, was selected as the main definition of NWO to test possible relationships. Dietary factors included consumption of energy, macro-nutrients intake, frequency of meals, fried foods’ and grilled foods’ consumption, and salt intake.Results: Overall, 1038 participants (513 men and 525 women) were studied with a mean age of 41.04 ± 6.98 years. 35.9% had normal weight and 63.0% were overweight or obese according to BMI criteria. Based on WHO criteria, the prevalence of NWO was 21.68% and 26.63% among men and women, respectively. Women were more likely to have high body fat than men (p<0.001). No significant relationship was observed between any dietary factor and NWO.Conclusions: NWO was prevalent among university employees. No relationship was observed between dietary factors and NWO. Considering the high cardio-metabolic risk of this condition, it needs further attention to acknowledge and control.
The ability of phase angle to predict death risk factors in maintenance hemodialysis patients
Authors: Xu Yuanzhao , Ling Shuyi , Liu Zheyan , Luo Denggui , Qi Airong , Zeng Youjia 
Published: April 2022

Abstract
Objectives: To investigate the ability of phase angle and body composition to predict the death risk factors of maintenance hemodialysis (MHD) patients. Methods: We studied the cause of death in 43 MHD patients treated at our hemodialysis center between January 2016 and December 2021 and compared them with the 71 patients who survived. Body composition was measured using direct segmental multi­frequency bioelectrical impedance to obtain phase angle, fat-free mass(FFM), extracellular water/total body water(ECW/TBW), and waist circumference (WC). Laboratory test data were collected. Phase angle cut-off value associated variables were calculated using ROC analysis. The ability of body composition variables to predict death risk factors in MHD patients was evaluated. Results: The most common cause of death was cardiovascular disease. ROC curve analysis showed that the optimal cut-off values for phase angle as death risk factors in MHD patients was 4.50°. Moreover, in MHD patients, lower phase angle, aging and hypoproteinemia are death risk factors. Conclusion: Cardiovascular disease is the most common cause of death in MHD patients. Lower phase angle, aging, and hypoproteinemia can indicate risk of death in MHD patients. The potential mechanism of lower phase angle to predict the prognosis of MHD patients.
Dysfunction of the BDNF-TrkB signaling pathway contributes to learning and memory impairments induced by neuroinflammation in mice
Authors: Zhang Wen , Ge Meng-meng , Zhang Long-Qing , Yuan Xiao-Man , Han Si-yi , Manyande Anne , Tian Yu-Ke , Tian Xuebi 
Published: April 2022

Abstract
Background
Evidence suggests neuroinflammation is the main mechanism in cognitive dysfunction. The brain-derived neurotrophic factor (BDNF) is involved in learning and memory via binding to tyrosine kinase B (TrkB) receptors. Herein, we mainly tested roles of the BDNF-TrkB signaling pathway and its downstream cascades in lipopolysaccharide (LPS) induced cognitive dysfunction in mice.
Methods
Mice were treated with LPS and 7,8-DHF for 7 days, and learning and memory function was evaluated by the novel object recognition test (NORT). Western blot elucidated roles of the BDNF-TrkB signaling pathway and its downstream cascades in LPS mice.
Results
The NORT showed that LPS induced learning and memory deficits in mice. LPS increased the levels of IL-1β, IL-6, and TNF-α in the serum of mice. In the hippocampus and medial prefrontal cortex (mPFC) regions, LPS reduced protein levels of BDNF, p-TrkB, Bcl-2, p-ERK1/2, p-CaMK2, p-CREB and p-GluR1 and increased the expression of Bax. In the entorhinal cortex (EC), levels of BDNF, p-TrkB, Bcl-2, p-CaMK2 and p-CREB proteins were reduced and the protein level of Bax was increased in LPS mice. 7,8-DHF could alleviate these disorders in LPS mice and improved their learning and memory function, however, the TrkB antagonist ANA12 effectively reversed the effects of 7,8-DHF.
Conclusion
These results revealed that the BDNF-TrkB signaling pathway and its downstream cascades disorders contributed to neuroinflammation induced cognitive dysfunction in mice. 7,8-DHF could become a new therapeutic drug for cognitive dysfunction induced by BDNF-TrkB signaling pathway disorders in neurodegenerative diseases.
The Shear Strength Behaviour of Natural Joint Infill.
Authors: Bhardwaj Sandeep , Rao K. Seshagiri 
Published: April 2022

Abstract
The shear strength of the infill or gouge material inside infilled joints has a serious impact on the infilled joint shear strength. Initial Barton’s study considers only the infill strength as an infilled joint strength. Things have changed since then now asperity, joint roughness, infill particle size also plays critical role in infill joints. This study giving proper justification in analyzing the role of particle sizes of infill material in the shear strength of infill joints. Direct shear environment in insitu natural joints are simulated through plane Plaster of Paris joints filled with lime stone infill with different grades of sizes in infill material. The choice of limestone infill is due to its strong affinity to seepage water. This study giving comparisons of shear strengths with respect to different grades of sizes of infill lime stone in plane Plaster of Paris(POP) limestone infilled joints in CNL condition.
Using Text Mining to Identify Key Dimensions of Service Quality for the Indian Public Sector Banks' Mobile Banking Apps
Authors: Halvadia Nirav B. , Halvadia Shekha , Purohit Rajen 
Published: April 2022

Abstract
The purpose of this study is to identify service quality dimensions that are very important for satisfied mobile banking app users of the Indian public sector banks using customer online reviews (CORs) analysis. A total of 5294 reviews of satisfied mobile banking app users (positive reviews) of leading Indian public sector banks (State Bank of India, Punjab National Bank, and Bank of Baroda) were collected from Google Play Store for text mining and the collected reviews were written from January 2018 to January 2022. Text indexing was performed after finding the string length and word count of all reviews. After text indexing, N-gram Analysis and word cloud analysis were performed using NLP models of Python software. Three important service quality dimensions for satisfied mobile banking app users (users with positive reviews) of the Indian public sector banks were identified. These dimensions were security, ease of use, and convenience. Mobile banking app users of Indian Public Sector banks are happy and satisfied because they perceive that the app is secure, convenient, and easy to use. The Indian public sector banks should position their mobile banking apps as secure and easy mobile banking apps for money transfers. The findings of this research are very useful to managers of Indian public sector banks in improving customer loyalty, getting new customers, and promoting their mobile banking apps in effective ways. This paper is a pioneer study in identifying important service quality dimensions for satisfied users of any mobile banking app in India using a text mining approach.
Development and validation of a nomogram model to predict the prognosis of intrahepatic cholangiocarcinoma
Authors: Chen Yi , Huang Liyun , Wei Zuwu , Liu Xiaoling , Chen Lihong , Wang Bin 
Published: April 2022

Abstract
Background
The effective method for predicting prognosis of ICC is still lack. This study aims to establish and verify an effective prognostic nomogram for intrahepatic cholangiocarcinoma (ICC) after partial hepatectomy.
Methods
A nomogram model was developed in a cohort of 127 patients from January 2015 to December 2019. General clinical characteristics including preoperative physical examination data and postoperative pathological features were obtained. The independent risk factors identified by univariate and multivariate COX proportional hazards regression models were used to construct nomogram model. Predictive accuracy and discriminative ability were determined using a concordance index and a calibration curve. In addition, the clinical significance of postoperative pathological subtypes was analyzed by Kaplan-Meier.
Results
Univariate analysis and multivariate COX regression analysis revealed that CEA, maximum diameter, tumor number, and large duct type ICC. These variables were incorporated into the nomogram and the C-index for one year and three year overall survival prediction was 0.765 (95% CI: 0.672–0.814) and 0.695 (95% CI: 0.672–0.814), respectively. Postoperative pathological analysis showed that the large duct ICC had a distinct clinicopathological features and poor outcome.
Conclusion
The proposed nomogram enables a prognostic prediction for patients with ICC and postoperative subclassification of ICC is of great significant to the prognosis of ICC.
PlagueKG: A plague knowledge graph based on biomedical literature mining
Authors: Li Jin , Gao Jing , Feng Baiyang , Jing Yi 
Published: April 2022

Abstract
BackgroundPlague is an extremely horrific infectious disease caused by Yersinia pestis. Its mortality rate is exceedingly high that threatens the lives of human and animals seriously. There is a vast amount of knowledge related to plague in the literature at present. It is particularly important to obtain useful information from an enormous amount of literature and intuitively represent it in the form of knowledge graph. This will provide help to researchers to quickly understand plague’s complex pathogenesis and potential therapeutic approaches and provide the potential action mechanism of corresponding drug candidates. Consequently, the speed of vaccine research and development could be accelerated.ResultsThis paper identifies and extracts plague-related entities and relations based on 5388 abstracts that obtained from PubMed biomedical literature library automatically. Then we construct the plague knowledge graph called PlagueKG, which contains 9633 nodes of 33 types such as disease, gene, protein, species, symptom, treatment, geographic location and so on, and 9466 association relations such as disease-gene, gene-protein, disease-species and so forth. The Neo4j graph database is used to store the relational data in the form of triple. Finally, a multi-factor correlation knowledge graph centered on plague is constructed, as well as a plague knowledge base platform.ConclusionsWe extracted and integrated knowledge from existing plague-related literature using text mining techniques, and constructed a plague knowledge graph, which shows detailed plague-related knowledge in an intuitive and clear way. To the best of our knowledge, it is the first plague knowledge graph that is built using literature mining techniques. In addition, our plague knowledge base platform successfully managed and visualized a large amount of structured data related to plague. Researchers can acquire integrated plague information more conveniently by using this platform. It provides more direct and comprehensive knowledge of the disease.
Berberine maintains intestinal homeostasis through modulating TLR4/ NF-κB / MTORC pathway and autophagy in cats
Authors: Guo MengYao , Cao JingWen , Chen MiaoYu , Li Xueying 
Published: April 2022

Abstract
Background Inflammatory bowel disease (IBD), a disease that seriously harms human and animal health, has attracted many researchers' attention because of its complexity and difficulty in treatment. Most research has involved rats and dogs, and very little was cats. We should know that gut microbiota varies significantly from animal to animal. Traditional Chinese Medicine and its monomer component have many advantages compared with antibiotics used in pet clinics. Numerous studies have shown berberine (berberine hydrochloride， BBr) therapeutic value for IBD; however, the specific mechanism remains to consider.Results We assessed gut pathology and analyzed fecal bacterial composition using Histological staining and 16S rRNA sequence. DSS administration destroyed intestinal mucosal structure and changed the diversity of intestinal flora relative to control. RT-PCR and western blot confirmed specific molecular mechanisms that trigger acute inflammation and intestinal mucosal barrier function disruption after DSS treatment. And autophagy inhibition is typical pathogenesis of IBD. Interestingly, berberine ameliorates inflammation during the development of the intestinal by modulating the TLR4(Toll-like receptors 4)/NF-κB signaling pathway and activating autophagy. Berberine significantly reduces tumor necrosis factor α(TNF-α), interleukin (IL)-6, and IL-1β expression in cats' serum. Enhancing the antioxidant effect of IBD cats is one of the protective mechanisms of berberine. We demonstrated that berberine repairs intestinal barrier function by activating the mTOR(mammalian target of rapamycin) complex, which inhibits autophagy.Conclusions Berberine can restore intestinal microbiota homeostasis and regulate the TLR4/ NF-Κb pathway, thereby controlling inflammatory responses. In addition, we propose a novel mechanism of berberine therapy for IBD, namely, berberine therapy can simultaneously activate MTORC and autophagy to restore intestinal mucosal barrier function in cats, which should be further studied to shed light on berberine to IBD.
Collection and uses of ethno-ecological species among Chuktia Bhunjia tribe of Odisha, India: Examining Sustainable Livelihood through Local Knowledge
Authors: Sabar Bhubaneswar , Midya Dipak K. 
Published: April 2022

Abstract
Introduction: Plant resources gathered from the wild are considered to be important sources of livelihood for many forest-dwelling communities who rely on these plants for food, fuelwood, medicine, agriculture and cultural purposes. This paper documents the ethno-ecological knowledge of Chuktia Bhunjia tribe of Odisha, India pertaining to collection and uses of plant species; and examines how the community people earn their livelihood sustainably by negotiating with those knowledges through various cultural beliefs.Methods: Data for this study were collected in few selected Chuktia Bhunjia villages during 2019-2020 largely through formal interview with local people including farmers, herbalists and ethno-veterinarians of both genders. Participant observation were used to understand resource use patterns that were documented through narrative and case study method.Results: This study documents 193 plant species used by Chuktia Bhunjia for different purposes with varied life forms: tree species (n=77) followed by shrub (38), herbs (28), climber (20) and so on. The Chuktia Bhunjia largely collect fruits (n=60) followed by leaves (35), stem (28), whole plants (25), roots (25), etc. that are used for consumption, medicine, oil extraction, house construction, agriculture and cultural purposes. Data reveals that ethno-ecological knowledge among them continue to shape their livelihood but is governed by set of customary rules with regard to collection and consumption. The cultural reproduction of ecological knowledge intertwined with institutionalised social norms, socialisation, and inherent ecological worldview are although predominantly reported; the gradual state intervention and market influence have altered their interaction with ecological resources.Conclusion: The ethno-ecological practice among Chuktia Bhunjia is a cultural process in which culture is found to be an intermediary tool to negotiate with the local landscape for collective survival. Yet, socio-economic transformation among them because of state intervention has altered their ecological relationships and negatively impacted on knowledge, cultural diversity and identity. At policy level, given the implications of ethno-ecological species in food and medicine there is a need to screen those species to measure the medicinal potency and nutritive value for wider acceptability. Besides, non-destructive way of harvesting of ethno-ecological species can be encouraged that can possible only with the promotion of cultural diversity, although mere attempts to integrate their knowledge with scientific knowledge can add substantial benefit to the knowledge holders.