bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of stable radon fluoride molecules and geometry optimization using first-principle calculations
Authors: Kang Jaeeun , Park Ina , Shim Ji Hoon , Kim Duck Young , Um Wooyong 
Published: October 2022

Abstract
Noble gases possess extremely low reactivity because their valence shells are closed. However, previous studies have suggested that these gases can form molecules when they combine with other elements with high electron affinity, such as fluorine. Radon is a naturally occurring radioactive noble gas, and the formation of radon-fluorine molecules is of significant interest owing to its potential application in future technologies that address environmental radioactivity. Nevertheless, because all isotopes of radon are radioactive and the longest radon half-life is only 3.82 days, experiments on radon chemistry have been limited. Here, we study the formation of radon molecules using first-principles calculations; additionally, possible compositions of radon fluorides are predicted using a crystal structure prediction approach. Similar to xenon fluorides, di-, tetra-, and hexa-fluorides are found to be stabilized. Coupled-cluster calculations reveal that RnF6 stabilizes with Oh point symmetry, unlike XeF6 with C3V symmetry. Furthermore, relativistic effects are considered to calculate physical properties, such as bond length, bond angle, and vibrational spectra, and the results suggest that relativistic effects should be considered to describe properly many-electrons of Rn. The molecular stability of radon fluoride obtained through calculations may lead to advances in radon chemistry research.
Characterisation of Clostridioides difficile spore response to sodium hypochlorite using EM-imaging and Raman Spectroscopy
Authors: Malyshev Dmitry , jones Imogen , McKracken Matthew , Harper Glenn , Lovleen Tina Joshi , Andersson Magnus 
Published: October 2022

Abstract
Background Clostridioides difficile is a spore forming bacterial species that is the major causative agent of serious infection in hospitals. C. difficile spores are highly resilient to disinfection methods and to prevent infection, common cleaning protocols use sodium hypochlorite solutions to decontaminate hospital surfaces and equipment. However, there is a balance between minimising the use of harmful chemicals to the environment and patients as well as the need to eliminate spores, which can have varying resistance properties between strains. In this work, we compare the effect of sodium hypochlorite on different C. difficile clinical isolates and the chemical's impact on spores' biochemical composition. Biochemical changes can, in turn, change spores' vibrational spectroscopic fingerprints, which can impact the possibility of detecting spores in a hospital using Raman based methods.
Results First, we found that the isolates show different susceptibility to hypochlorite, with the R20291 strain, in particular, showing less than 1 log reduction in viability for a 0.5 % hypochlorite treatment, far below typically reported values for C. difficile. Second, TEM and Raman spectra analysis of hypochlorite-treated spores revealed that some hypochlorite-exposed spores remained intact and not distinguishable to controls. Finally, we saw differences in the ultra-structure of C. difficile and B. thuringiensis spores in response to hypochlorite.
Conclusion This study highlights the ability of certain C. difficile spores to survive practical disinfection exposure as well as the changes in spore spectra that can be seen using Raman spectroscopy. These findings are important to consider to avoid a false-positive response when screening decontaminated areas.
An Efficient High-Order Two-Level Explicit/Implicit Numerical Scheme For Two-Dimensional Time Fractional Mobile/Immobile Advection-Dispersion Model
Authors: Ngondiep Eric 
Published: October 2022

Abstract

This paper constructs a new two-level explicit/implicit numerical scheme in an approximate solution for the two-dimensional time fractional mobile/immobile advection-dispersion problem. The stability and error estimates of the proposed technique are deeply analyzed in the $L^{\infty}(0,T;L^{2})$-norm. The developed approach is less time consuming, fourth-order in space and temporal accurate of order $O(k^{2-\frac{\lambda}{2}})$, where $k$ is the time step and $\lambda$ denotes a positive parameter less than $1$. This result shows that the two-level explicit/implicit formulation is fast and more efficient than a large class of numerical schemes widely discussed in the literature for the considered problem. Numerical experiments are performed to verify the theoretical studies and to demonstrate the efficiency of the new numerical method.
Oligogenic prediction of eye and hair colour in the Danish population
Authors: Cabrejas Amaia , Athanasiadis Georgios 
Published: October 2022

Abstract
Genetic predictions of external traits are commonplace in current research, but little is known about the performance of such predictions in Nordic populations. Here, we perform eye and hair colour prediction in a sample of 723 Danish high school students using the oligogenic HIrisPlex method. We analysed the genetic structure of the Danish population by use of principal component analysis. Hair and eye colour predictions were carried out with an R script that was based on the HIrisPlex method. We predicted brown, blue and green colour with an accuracy of 92.17%, 98.38% and 0.73%, respectively. We also obtained accuracies of 80.95% for black, 93.72% for blond, 6.16% for brown and 53.33% for red hair colour. Our predictions were overall less accurate than previously reported in the HirisPlex study. The dissimilarities might be explained by differences in genetic ancestry between training and target samples. Due to the complexity eye and hair colour present as traits, a polygenic risk model is more suitable for their prediction.
Sirt1 overexpression inhibits fibrous scar formation and improves outcome after cerebral ischemic injury by deacetylation of 14-3-3ζ
Authors: Chen Yue , Huang Jiagui , Liu Jie , Zhu Huimin , Li Xuemei , Wen Jun , Tian Mingfen , Ren Jiangxia , Zhou Li , Yang Qin 
Published: October 2022

Abstract
Fibrous scar is one of major factors for hindering synaptic regeneration after central neural system (CNS) injury. Silencing information regulator 2 related enzyme 1 (Sirt1) can regulate lung, liver, kidney and heart fibrosis. However, it is unclear how the fibrous scar forms and is regulated and it is unknown whether and how Sirt1 regulates formation of the fibrous scar after cerebral ischemic stroke. The present study tests whether and how Sirt1 affects formation of the fibrous scar following cerebral ischemic injury. Therefore, we examined the expression and localization and the effects of Sirt1 on the formation of the fibrotic scar after middle cerebral artery occlusion/reperfusion (MCAO/R) injury in vivoand transforming growth factor β1 (TGF-β1)-induced meningeal fibroblasts migration, proliferation, transdifferentiation and extracellular matrix (ECM) secretion. Finally, we explored the molecular mechanisms underlying the Sirt1-regulated fibrosis process in vitro. We found that MCAO/R injury induced fibrotic scar formation in the ischemic area accompanied with downregulation of Sirt1 expression. Overexpression of Sirt1 reduced the infarct volume in acute stage, alleviated loss of Nissl body and formation of fibrotic scar in middle and later periods, further promoted the synaptic plasticity and neurological function recovery. Similarly, Sirt1 expression is also downregulated during TGF-β1-induced fibrosis model. Sirt1 overexpression inhibited fibroblasts migration, proliferation, transdifferentiation into myofibroblasts and secretion of ECM by controlling deacetylation of lysine at K49 and K120 sites of 14-3-3ζ in vitro. Therefore, we believe Sirt1 can regulate fibrous scar formation and improve outcome after cerebral ischemic stroke through controlling deacetylation of 14-3-3ζ.
Study on Mechanical Properties and Energy Change of Rock Materials in Whole Splitting Process Based on peridynamics
Authors: Li Hewan , Liu Jian , Wang Laigui , Ren Tianjiao 
Published: October 2022

Abstract
Aiming at the problem that the evolution process of rock internal deformation and fracture cannot be observed directly, this paper proposes that based on the bond-base peridynamic theory in peridynamics and the PMB model of brittle materials, combined with laboratory experiments, rock samples with different inclination angles are analyzed from the angle of energy. The method of analyzing the whole process of shearing, and the lammps software is used to simulate the internal energy change of rock-like materials under shear conditions, and the damage evolution law of samples with different dip angles is studied from macro and micro perspectives.The result shows that prefabricated cracks and the inclination of cracks are important factors for specimen damage, which has important theoretical value for rock mechanics research. The research results can reduce the occurrence of rock burst accidents or reduce the difficulty of mine support, reduce the cost of mining engineering, and improve the mine safety level.
Effects of a mixture of Iranian native probiotics on kidney oxidative injuries induced by cadmium chloride: A biochemical, anti-inflammatory, Antioxidative and antiapoptosis approach
Authors: salar shakiba , keshtmand zahra 
Published: October 2022

Abstract
Introduction: Cadmium(Cd)tends to produce severe oxidative stress triggering serious clinical problems and tissues damage.The purpose of the current investigation was to study the efficacy of native Iranian probioticsin protection against Cd-induced kidney damages at histopathological and biochemical levels.
Material and Methods: Twenty-one adult male Wistar rats were randomized into three groups of seven rats(control,receivingCd(3mg/kg) and Cd+mix probiotics(Cd+Pro) for 30 days).Histological changes were assessed using H&E,Trichrome Masson, and PAS staining, and qRT-PCR was used for evaluating apoptotic,and pro-inflammatory genes expression levels. Serum biochemical parameters and tissue antioxidant status were also evaluated.
Result:The histopathological results revealed that the probiotic strains recovered the tissue damage caused by Cd in kidneys.The results of qRT-PCR showed the up-regulation of Bax,p53,caspase3 and down-regulation of Bcl2,TNF-α,and IL-6 gene expressions in the kidneys of Cd+mix Pro treated rats compared with Cd-treated animals.Also,Cd+Pro treated rats displayed a reduction in MDA,high levels of SOD,catalase activities,reduced serum contents of Na+,Creatinine, urea, finally higher levels of K+and total protein compared toCd-treated animals.
Conclusion: Iranian native probiotics exhibited antioxidant, anti-inflammatory, and anti-apoptotic functions it is suggested to use them in pharmaceutical studies to further investigate their health benefits.
Inverse scattering transform and dynamics of soliton solutions for nonlocal focusing modified Korteweg-de Vries equation
Authors: Zhang Xiao-Fan , Tian Shou-Fu , Yang Jin-Jie , Zhang Tian-Tian 
Published: October 2022

Abstract
The Riemann-Hilbert (RH) problem is developed to study the general N-soliton solutions of the nonlocal modified Korteweg-de Vries (mKdV) equation in this work. For the initial value belonging to Schwarz space, we firstly obtain the corresponding eigenfunctions and scattering data in the direct scattering process. Then the suitable RH problem of the nonlocal mKdV equation is successfully established. The exact expression of the solution for the equation is derived via solving the RH problem. Utilizing the symmetry of scattering data, the abundant phenomena corresponding to different eigenvalues are analyzed, including bounded solutions, singular solutions, degenerate solution and kink solutions. Finally, the propagation behaviors of the solution (including one-, two-, and three soliton) are observed, and the characteristic lines are further used to analyze the continuity and other phenomena of the solution.
Mathematics Subject Classification (2010) 35Q15 · 35Q51 · 45Q05
A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development
Authors: O'Keefe Ryan , Carli Annalisa , Baloyan David , Chisanga David , Shi Wei , Afshar-Sterle Shoukat , Eissmann Moritz , Poh Ashleigh , Pal Bhupinder , Seillet Cyril , Locksley Richard , Ernst Matthias , Buchert Michael 
Published: October 2022

Abstract
Although gastric cancer is a leading cause of cancer-related deaths, systemic treatment strategies remain scarce. Here, we report the pro-tumorigenic properties of the crosstalk between intestinal tuft cells and type 2 innate lymphoid cells (ILC2) that is evolutionarily optimized for epithelial remodeling in response to helminth infection. We demonstrate that tuft cell-derived interleukin 25 (IL25) drives ILC2 activation, inducing the release of IL13 and promoting epithelial tuft cell hyperplasia. While the resulting tuft cell - ILC2 feed-forward circuit promotes gastric metaplasia and tumor formation, genetic depletion of tuft cells or ILC2s, or therapeutic targeting of IL13 or IL25 alleviates these pathologies in mice. In gastric cancer patients, tuft cell and ILC2 gene signatures predict worsening survival in intestinal-type gastric cancer where ~40% of the corresponding cancers show enriched co-existence of tuft cells and ILC2s. Our findings suggest novel roles for ILC2 and tuft cells, along with their associated cytokine IL13 and IL25 as gatekeepers and enablers of metaplastic transformation and gastric tumorigenesis, thereby providing novel therapeutic vulnerabilities of for the treatment of these pathologies.
Evaluation of Soil CO 2 Efflux and its Influence Factors in a Revegetated Area in Tengger Desert, NW China
Authors: Nan Yicong , Huang Lei , Yang Yonggang , Yang Guisen , Wang Zeqing 
Published: October 2022

Abstract
Soil profile CO2 transport and production are vital in the carbon stock in desert artificial vegetation ecosystem. In this study, the soil profile CO2 concentration, soil water content and temperature at depths of 0–40 cm were measured at four revegetated sites (1956, 1964, 1981 and 1987), located in the southeastern edge of Tengger desert, China. The gradient method was applied to simulated soil gas diffusion coefficient and soil profile CO2 efflux. We found that the soil profile CO2 concentration increased with depths, while the soil CO2 diffusion coefficient, soil CO2 efflux and production in upper layers were significantly higher than those in bottom layers. The CO2 diffusion coefficient decreased at first and then increased with revegetation age. The soil profile CO2 concentration, CO2 efflux and production increased with revegetation age. The simulated soil surface CO2 efflux were 0.54 µmol·m− 2·s− 1, 0.49 µmol·m− 2·s− 1, 0.44 µmol·m− 2·s− 1 and 0.25 µmol·m− 2·s− 1 at 1956, 1964, 1981 and 1987 revegetated sites, respectively. The soil surface CO2 efflux mainly came from the layers of 0–10 cm, which contributed to 76.4% − 94.9% of the total. The structural equation modeling (SEM) explained 97.0% of the variations in soil surface CO2 efflux (F0). The effects of soil CO2 concentration, temperature and water content in the layers of 10 cm, and plant properties on soil surface CO2 efflux were 0.977, 0.516, -0.358 and − 0.156, respectively, and the interaction between soil temperature and water content was 0.439, which meant that the soil temperature and water content significantly influenced soil CO2 efflux.
Study on magnetic pulse crimping process for joining large diameter aluminum alloy tube/magnesium alloy shaft
Authors: Chen Chang , Han Zichuan , Cui Junjia , Li Guangyao , Jiang Hao 
Published: October 2022

Abstract
A structure for joining 6061T6 aluminum alloy tube and AZ31B magnesium alloy shaft via the magnetic pulse crimping process was proposed. The forming process, mechanical properties, failure modes, corrosion behaviors of the joint were studied. The results showed that the enormous Lorentz force drove the wall of aluminum alloy tube to move towards the groove of magnesium alloy shaft at high-velocity, thus realized mechanical locking and formed joint. Through torsion tests, it was found that the mechanical properties of the joint with different process parameters varied. There were two failure modes for joint: torsional separation and torsional crack. Specifically, discharge time, groove angle and discharge energy for torsional crack was respectively 1, 90°, 28 kJ and 3, 90°, 25kJ. The maximum torque was up to 961.99N·m under discharged twice, 90° groove angle and 25kJ discharge energy. Through neutral salt spray corrosion tests, it was found that the maximum torque only decreased by 28.03% after corrosion for 192h. It indicated that the corrosion resistance of joint was good relatively.
The angular gyrus serves as an interface between the non-lexical reading network and the semantic system - evidence from dynamic causal modeling
Authors: Junker Frederick Benjamin , Schlaffke Lara , Lange Joachim , Schmidt-Wilcke Tobias 
Published: October 2022

Abstract
Understanding encoded language, such as written words, requires multiple cognitive processes that act in a parallel and interactive fashion. These processes and their interactions, however, are not fully understood. Various conceptual and methodical approaches including computational modeling and neuroimaging have been applied to better understand the neural underpinnings of these complex processes in the human brain. In this study, we tested different predictions of cortical interactions that derived from computational models for reading using dynamic causal modeling. Morse code was used as a model for non-lexical decoding followed by a lexical-decision during an MR examination. Our results suggest that individual letters are first converted into phonemes within the left parietal lobe, followed by a phoneme assembly to reconstruct word phonology, involving the left inferior frontal cortex. To allow the identification and comprehension of known words, the inferior frontal cortex then interacts with the semantic system via the left angular gyrus. As such, the left angular gyrus is likely to host phonological and semantic representations and serves as a bidirectional interface between the networks involved in language perception and word comprehension.
Are aluminum and iron resorbed from old leaves?
Authors: Hu Nan , Mao Qinggong , Sun Xibin , Xu Qianhao , Li Meimei , Chen Hao 
Published: October 2022

Abstract
Purpose
Leaf resorption is an important mechanism for plant nutrient conservation, but not all elements are resorbed by plants. It is generally believed that aluminum (Al) and iron (Fe) are not resorbed from old leaves due to their toxic effects. However, the fact is that positive Al and Fe resorptions have been found in some specific cases. To date, no one has addressed these specific cases and the mechanisms underlying.
Methods
Here, a data synthesis was conducted to explore the patterns and controls on leaf resorption efficiency of Al and Fe, based on 34 published studies with 272 data points. We aimed to answer whether and why Al and Fe can be resorbed from old leaves.
Results
The resorption efficiency of Al was positive in conifer plants (11.3%), but was negative in deciduous and evergreen plants (-94.2% and − 111.2%, respectively). The resorption efficiency of Fe was positive in nitrogen-fixing plants (39.2%), but was negative in non-nitrogen-fixing plants (-37.0%). Lower soil pH favored leaf Al resorption, but limited leaf Fe resorption. Higher precipitation inhibited leaf Fe resorption.
Conclusions
In contrast to the general belief, our study highlights that Al and Fe can be resorbed from old leaves, depending mainly on plant functional group and soil environment. This knowledge is an important supplement for understanding leaf resorption process, and helpful for modeling global biogeochemical cycles.
Hadamard bent sequences-survey and new results
Authors: Shi Minjia , Xiao Xianglin , Sole Patrick 
Published: October 2022

Abstract
A new notion of bent sequence related to Hadamard matrices was introduced recently, motivated by a security application (Solé et al, 2021). The subclass of self-dual bent sequences was studied from the standpoint of generation and symmetry (Shi et al., 2022). An analogous study was led for complex Hadamard matrices (Shi et al., submitted). We survey these recent results, and add some new results (asymptotics, Mutually Unbiased Hadamard matrices).
MSC (2020): 05B20, 94D10, 94B25
Development and validation of a diagnostic prediction model reminiscent of systemic inflammation and organ interaction in heart failure preserved ejection fraction (HFpEF) patients
Authors: Zhou Rong , Xia Yi-Yuan , Li Zheng , Wu Li-Da , Shi Yi , Ling Zhi-Yu , Zhang Jun-Xia 
Published: October 2022

Abstract
Purpose
Systemic inflammation and reciprocal organ interactions are associated with the pathophysiology of heart failure with preserved ejection fraction (HFpEF). Herein, we proposed a simple diagnostic model with markers from complete routine blood test as well as liver and renal dysfunction for HFpEF.
Patients and methods:
This is a hospital-based single-center, cross-sectional observation study. 1808 eligible patients with documented cardiovascular diseases were enrolled. HFpEF was diagnosed independently by two expert cardiologists according to the clinical manifestation, echocardiography and the N-Terminal pro B-type natriuretic peptide. A diagnostic model for HFpEF was developed by logistic regression and assessed by ROC and Brier score. Then, the model was validated by the 10-fold cross-validation and presented as nomogram and a web-based online risk calculator as well.
Results
Patients with HFpEF account for 47.23% in development data. Univariate, multivariate and LASSO regression analysis revealed that age, Hb, NLR, AST/ALT ratio, Cr, UA, atrial fibrillation, and pulmonary arterial hypertension were associated with HFpEF. The predictive model exhibited reasonably accurate discrimination (ROC, 0.753, 95% CI, 0.732 to 0.772) and calibration (Brier score was 0.200). Subsequent internal validation showed good discrimination and calibration (AUC = 0.750, Brier score was 0.202).
Conclusion
Our new diagnostic model incorporating markers of inflammation, liver-heart and kidney-heart interactions has the predictive ability for HFpEF, and may be helpful for timely diagnosis of patients with HFpEF.
WITHDRAWN: Investigation of regenerative effects of Theranekron ® and Misoprostol after partial hepatectomy in rats
Authors: YILMAZ İsmet , KANAT Burhan Hakan , YILDIZ Azibe , BİLGİÇ Yılmaz , BERK Ahmet , UYUMLU Ayşe Burçin , Burak Muhammet 
Published: October 2022

Abstract
Background/Aims:
In the present study we were aimed to investigate/compare regenerative effects of Theranekron® (TC) and Misoprostol (MS) after Partial Hepatectomy (PH) in rats.
Material and Methods:
This study was conducted in 38 rats, they were divided in to 5 groups and 14 days study periot.
Results, and Conclusions:
When considering biochemical and histopathological results; we were seen that before and after PH 7 days duration and used dozes of both drugs was not sufficient and also higher dozes and at least 10 days periot may be necessary. Althought some literatures were reported about positive effects of TC and MS on epithelial growing, we have not seen that they have not any positive effect on liver regeneration. For future research -at higher dozes and durations- may be found effective.