bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early glomerular filtration rate changes in living kidney donors and recipients: an example of renal plasticity
Authors: Rinne Ana González , Sorensen Cristian Acosta , Lima Sergio Luis , Gil Marta Gómez , Mena Natalia Negrín , Martín Laura Díaz , Ramírez Ana , Morales Adelaida , Vega Nicanor , Gallego Eduardo , Izquierdo Edduin Martín , Cabello Elisa , Rodríguez Ana Elena Rodríguez , González Jesús Pimentel , Escamilla Beatriz , Cruz Coriolano , Tamajón Lourdes Pérez , Ramírez Armando Torres , Gaspari Flavio , Ortiz Alberto , Porrini Esteban 
Published: January 2022

ABSTRACT

Background
In living kidney transplantation there are two different individuals, a healthy donor and a renal transplant recipient. This is an excellent human model to study factors that influence kidney function in the context of reduced renal mass and the adaptation of two comparable kidneys to different metabolic demands.

Methods
We analyzed the changes in measured glomerular filtration rate (GFR, iohexol) from pretransplantation to 12 months after transplantation in 30 donor–recipient pairs. Each donor was compared with his/her recipient. We defined a priori three different groups based on GFR differences at 12 months: donor &gt; recipient (Group A; 78 ± 8 versus 57 ± 8 mL/min), donor &lt; recipient (Group B; 65 ± 11 versus 79 ± 11 mL/min) and donor ≈ recipient (Group C; 66 ± 7 versus 67 ± 7 mL/min). Other factors like donor/recipient mismatches in body mass index (BMI), surface area and gender were evaluated.

Results
In Group A donors were mostly male and recipients were female (75% each). Donors had a higher baseline weight than their recipients. During follow-up, weight remained stable in donors but increased 7% in recipients. In Group B donors were mostly female (60%) and recipients male. At baseline, donors had a lower weight than recipients. At 12 months, weight was stable in donors but increased in recipients. In Group C donors were mostly (75%) female and recipients male. At baseline, donors had a higher BMI than their recipients. At 12 months, BMI was stable in donors but increased 14% in recipients. In multivariable analysis, higher GFR at 12 months was associated with higher baseline weight and GFR in donors and with male gender and higher baseline weight in recipients.

Conclusions
Kidneys from living donors are more ‘plastic’ than originally thought and respond to metabolic demands and weight changes of their new host. These changes should be taken into account when assessing GFR outcomes in this population.
GNIFdb: a neoantigen intrinsic feature database for glioma
Authors: Li Wendong , Sun Ting , Li Muyang , He Yufei , Li Lin , Wang Lu , Wang Haoyu , Li Jing , Wen Hao , Liu Yong , Chen Yifan , Fan Yubo , Xin Beibei , Zhang Jing 
Published: January 2022

Abstract

Abstract
Neoantigens are mutation-containing immunogenic peptides from tumor cells. Neoantigen intrinsic features are neoantigens’ sequence-associated features characterized by different amino acid descriptors and physical–chemical properties, which have a crucial function in prioritization of neoantigens with immunogenic potentials and predicting patients with better survival. Different intrinsic features might have functions to varying degrees in evaluating neoantigens’ potentials of immunogenicity. Identification and comparison of intrinsic features among neoantigens are particularly important for developing neoantigen-based personalized immunotherapy. However, there is still no public repository to host the intrinsic features of neoantigens. Therefore, we developed GNIFdb, a glioma neoantigen intrinsic feature database specifically designed for hosting, exploring and visualizing neoantigen and intrinsic features. The database provides a comprehensive repository of computationally predicted Human leukocyte antigen class I (HLA-I) restricted neoantigens and their intrinsic features; a systematic annotation of neoantigens including sequence, neoantigen-associated mutation, gene expression, glioma prognosis, HLA-I subtype and binding affinity between neoantigens and HLA-I; and a genome browser to visualize them in an interactive manner. It represents a valuable resource for the neoantigen research community and is publicly available at http://www.oncoimmunobank.cn/index.php.

Database URL
http://www.oncoimmunobank.cn/index.php
China’s Antitrust Probe into the Platform Economy – A Comment on the Alibaba Decision
Authors: Xiao Yukun 
Published: January 2022

Abstract
China’s competition authority imposed a record fine against the largest domestic online platform operator Alibaba. The decision concludes that Alibaba abused its dominant position in the market for online retail platform services by prohibiting merchants from selling or participating in promotional events on rival platforms. This article provides an overview of the grounds of the decision and a detailed analysis in the context of China’s anti-monopoly regulations and guidelines for the platform sector. The Alibaba decision is well-structured and reasoned, but also leaves some open questions in its competitive assessment. In addition to the fine, the competition authority issued a guidance letter to Alibaba and initiated a three-year-long compliance monitoring. The penalty decision also has an industry-wide deterrent impact through the follow-up administrative supervisory meeting with major platform operators. The Alibaba decision marks a turning point in China’s antitrust interventions in the platform economy in the shift from a very tolerant and cautious approach towards a more proactive and stringent one.
The Neglected Gut Microbiome: Fungi, Protozoa, and Bacteriophages in Inflammatory Bowel Disease
Authors: Guzzo Gina L , Andrews Jane M , Weyrich Laura S 
Published: January 2022

Abstract
The gut microbiome has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Studies suggest that the IBD gut microbiome is less diverse than that of the unaffected population, a phenomenon often referred to as dysbiosis. However, these studies have heavily focused on bacteria, while other intestinal microorganisms—fungi, protozoa, and bacteriophages—have been neglected. Of the nonbacterial microbes that have been studied in relation to IBD, most are thought to be pathogens, although there is evidence that some of these species may instead be harmless commensals. In this review, we discuss the nonbacterial gut microbiome of IBD, highlighting the current biases, limitations, and outstanding questions that can be addressed with high-throughput DNA sequencing methods. Further, we highlight the importance of studying nonbacterial microorganisms alongside bacteria for a comprehensive view of the whole IBD biome and to provide a more precise definition of dysbiosis in patients. With the rise in popularity of microbiome-altering therapies for the treatment of IBD, such as fecal microbiota transplantation, it is important that we address these knowledge gaps to ensure safe and effective treatment of patients.
Natural Herbal Remedy Wumei Decoction Ameliorates Intestinal Mucosal Inflammation by Inhibiting Th1/Th17 Cell Differentiation and Maintaining Microbial Homeostasis
Authors: Wu Xiaohan , Chen Huimin , Gao Xiang , Gao Han , He Qiong , Li Gengfeng , Yao Jun , Liu Zhanju 
Published: January 2022

Abstract

Background
Evidence has shown that the traditional Chinese herbal medicine Wumei decoction (WMD) has a protective effect on ulcerative colitis. Here, we studied the anti-inflammatory effects and potential mechanisms of WMD on chronic colitis in mice.

Methods
A dextran sulfate sodium (DSS)–induced chronic colitis model and CD45RBhighCD4+ T cell transfer model were established in mice. Body weight, Disease Activity Index, and colon length were assessed, and histopathology was confirmed by hematoxylin and eosin staining. Colon tissue samples were collected to detect the frequencies of various immune cells, expression of cytokines, and tight junction–related proteins using flow cytometry, quantitative real-time polymerase chain reaction, and enzyme-linked immunosorbent assay, respectively. 16S ribosomal DNA sequencing was performed to distinguish differential microbiota of fecal samples.

Results
Severe chronic colitis was observed in mice after DSS exposure and in Rag1-/- mice reconstituted with CD45RBhighCD4+ T cells, as manifested by weight loss, hematochezia, and shortening and thickening of the colon, which were reversed by WMD treatment. WMD markedly suppressed intestinal mucosal CD4+ T cell differentiation and the secretion of proinflammatory cytokines (eg, tumor necrosis factor α, interleukin-1β, interferon γ, and IL-17A) by flow cytometry, quantitative real-time polymerase chain reaction, and enzyme-linked immunosorbent assay, respectively. Moreover, WMD promoted the expression of occludin, zonula occludens-1, and E-cadherin, thereby maintaining the epithelial barrier function. Additionally, 16S ribosomal DNA sequencing revealed that WMD regulated the dysbiosis of gut microbiota in CD45RBhighCD4+ T cell-reconstituted Rag1-/- mice, evidenced by an increase of Allobaculum and Bacteroides and a decrease of Ileibacterium.

Conclusions
WMD ameliorates chronic colitis in mice induced by DSS or reconstituted with CD45RBhighCD4+ T cells through suppressing Th1/Th17 cell differentiation and the secretion of proinflammatory cytokines, maintaining epithelial barrier function, and improving the dysbiosis.
Identifying species complexes based on spatial and temporal clustering from joint dynamic species distribution models
Authors: Omori Kristen L , Thorson James T 
Published: January 2022

AbstractData-limited species are often grouped into a species complex to simplify management. Commonalities between species that may indicate if species can be adequately managed as a complex include the following: shared habitat utilization (e.g., overlapping fine-scale spatial distribution), synchrony in abundance trends, consistent fishing pressure or gear susceptibility, or life history parameters resulting in similar productivity. Using non-target rockfish species in the Gulf of Alaska as a case study, we estimate spatial and temporal similarities among species to develop species complexes using the vector autoregressive spatio-temporal (VAST) model, which is a joint dynamic species distribution model. Species groupings are identified using Ward's hierarchical cluster analysis based on spatial and temporal species correlations. We then compare the spatial and temporal groupings with cluster analysis groupings that use exploitation and life history characteristics data. Based on the results, we conclude that there are some rockfish species that consistently group together, but the arrangement and number of clusters differ slightly depending on the data used. Developing species complexes for fisheries management requires a variety of analytical approaches including species distribution models and cluster analyses, and these can be applied across the full extent of available data sources.
Self-reported sexually transmitted infections among adolescent girls and young women in sub-Saharan Africa
Authors: Dadzie Louis Kobina , Agbaglo Ebenezer , Okyere Joshua , Aboagye Richard Gyan , Arthur-Holmes Francis , Seidu Abdul-Aziz , Ahinkorah Bright Opoku 
Published: January 2022

Abstract

Background
Sexually transmitted infections (STIs) affect individuals of all ages, but adolescent girls and young women are disproportionately affected. We examined the prevalence and factors associated with self-reported STIs (SR-STIs) among adolescent girls and young women in sub-Saharan Africa (SSA).

Methods
Demographic and Health Survey data of 27 sub-Saharan African countries were used for the study. The sample size comprised 68944 adolescent girls and young women (15–24 y of age). The outcome variable was SR-STIs. Multilevel binary logistic regression analysis was performed to identify factors associated with SR-STIs.

Results
On average, the prevalence of SR-STIs among adolescent girls and young women in SSA was 6.92%. The likelihood of SR-STIs was higher among young women aged 20–24 y (adjusted odds ratio [aOR] 1.36 [confidence interval {CI} 1.27 to 1.46]), those not married (aOR 1.64 [CI 1.51 to 1.79]), those working (aOR 1.20 [CI 1.12 to 1.27]), those whose age at first sex was ≤19 y (aOR 1.99 [CI 1.80 to 2.20]), those with two or more sex partners (aOR 1.56 [CI 1.35 to 1.80]), those who listened to radio (aOR 1.26 [CI 1.17 to 1.35]), those in urban areas (aOR 1.42 [CI 1.30 to 1.51]) and those with a wealth index of rich (aOR 1.28 [CI 1.17 to 1.40]) compared with their counterparts. In contrast, those with a primary (aOR 0.86 [CI 0.78 to 0.94]) or secondary/higher level of education (aOR 0.83 [CI 0.75 to 0.92]) compared with those with no formal education and those who were exposed to television (aOR 0.90 [CI 0.84 to 0.98]) compared with those who were not exposed were less likely to report STIs.

Conclusions
Our findings demonstrate the need for countries in SSA to commit towards reducing the incidence of STIs. Community-based health educational programs are required to intensify the awareness of STIs and their prevention in various sub-Saharan African countries considering the factors that expose adolescent girls and young women to STIs.
Law Enforcement and Bargaining over Illicit Drug Prices: Structural Evidence from a Gang’s Ledger
Authors: Leong Kaiwen , Li Huailu , Rysman Marc , Walsh Christoph 
Published: January 2022

AbstractWe estimate a structural model of bargaining between a branch of a large transnational gang and pushers using data from detailed records kept by the gang. The model allows for the gang’s relative bargaining power to differ for pushers with different characteristics, such as those with addictions or borrowing problems. Exploiting supply shocks in our data, we use the estimated model to study the effectiveness of various enforcement strategies. We find that targeting pushers is more effective at reducing quantities sold compared to targeting the gang’s upstream supply chain.
Enhanced Excito-Repellency of Binary Mixtures of Plant-Based Mosquito Repellents Against Culex quinquefasciatus Say (Diptera: Culicidae), a Night Biting Mosquito Species
Authors: Boonyuan Wasana , Ahebwa Alex , Nararak Jirod , Sathantriphop Sunaiyana , Chareonviriyaphap Theeraphap 
Published: January 2022

Abstract
Efficacies of essential oils (EOs) of Vetiveria zizanioides (L.) Nash. (Poales: Poaceae) (VZ EO), Cananga odorata (Lam) Hook. F. & Thomson (Magnoliales: Annonaceae) (CO EO), and crude extract (CE) of Andrographis paniculata (Burm.F.) Wall ex. Nees (Lamiales: Acanthaceae) (AP CE), against laboratory (lab) and field strains of Culex quinquefasciatus Say were investigated. Irritant and repellent activities of individual and binary mixtures of plant extracts were compared with N,N-diethyl-m-toluamide (DEET) using an excito-repellency system. The irritant activity (direct tarsal contact), the mean percent escape response of VZ EO (91.67%, 83.33%), and CO EO (80%, 88.33%) were not significantly different compared with DEET (88.33%, 95%) against lab and field strains, respectively. Similarly, irritant responses in combinations (1:1 and 1:2, v:v) of either VZ EO or CO EO with AP CE were not significantly different from DEET against both strains (P &gt; 0.001). The repellent activity (no tarsal contact), the mean percent escape response of VZ EO (68.33%), CO EO (61.67%), and VZ EO+AP CE (1:1, v:v) (81.67%) against lab strain and CO EO (85%) against field strain were not significantly different from that of DEET (P &gt; 0.001). Interestingly, the greatest contact irritancy of VZ EO+AP CE (1:1, v:v) (96.67%) (P = 0.0026) and a stronger repellency response of CO EO (85%) (P = 0.0055) produced significantly different patterns of escape response compared with DEET against both lab and field strains, respectively. The EOs of VZ EO and CO EO or their mixture with AP CE showed potential as plant-based active ingredients for mosquito repellents. In addition, the major chemical constituents of VZ EO were β-vetivone (6.4%), khusimol (2.96%), and α-vetivone (2.94%) by gas chromatograpy–mass spectrometry.
Narrowing Insurance Disparities Among Children and Adolescents With Cancer Following the Affordable Care Act
Authors: Ji Xu , Hu Xin , Castellino Sharon M , Mertens Ann C , Yabroff K Robin , Han Xuesong 
Published: January 2022

Abstract
Despite advances toward universal health insurance coverage for children, coverage gaps remain. Using a nationwide sample of pediatric and adolescent cancer patients from the National Cancer Database, we examined effects of the Affordable Care Act (ACA) implementation in 2014 with multinomial logistic regressions to evaluate insurance changes between 2010-2013 (pre-ACA) and 2014-2017 (post-ACA) in patients aged younger than 18 years (n = 63 377). All statistical tests were 2-sided. Following the ACA, the overall percentage of Medicaid and Children’s Health Insurance Program–covered patients increased (from 35.1% to 36.9%; adjusted absolute percentage change [APC] = 2.01 percentage points [ppt], 95% confidence interval [CI] = 1.31 to 2.71; P &lt; .001), partly offset by declined percentage of privately insured (from 62.7% to 61.2%; adjusted APC = −1.67 ppt, 95% CI = −2.37 to −0.97; P &lt; .001), leading to a reduction by 15% in uninsured status (from 2.2% to 1.9%; adjusted APC = −0.34 ppt, 95% CI = −0.56 to −0.12 ppt; P = .003). The largest declines in uninsured status were observed among Hispanic patients (by 23%; adjusted APC = −0.95 ppt, 95% CI = −1.67 to −0.23 ppt; P = .009) and patients residing in low-income areas (by 35%; adjusted APC = −1.22 ppt, 95% CI = −2.22 to −0.21 ppt; P = .02). We showed nationwide insurance gains among pediatric and adolescent cancer patients following ACA implementation, with greater gains in racial and ethnic minorities and those living in low-income areas.
Stumpage Price Distributions and Correlations and Their Impact On Timberland Investment Modeling: An Analysis Using Maine Stumpage Prices (1961–2017)
Authors: Eckardt Rory , Lutz Jack , MacKay Donald G , McKeever Daniel 
Published: January 2022

AbstractThis paper analyzes more than 55 years of Maine stumpage prices and finds that the normal distribution does not best characterize many of the primary species and products located in the state. Nontrivial correlations are also identified among many of the species and product stumpage prices. The implications of these findings are discussed for the value of species and age diversification and the use of financial simulations to assess projected return distributions from timberland investments. Specifically, we look at two hypothetical timberland investment scenarios with varying amounts of species and age diversification and demonstrate the differences in the projected return distributions timber analysts would obtain with simple (normal distribution and independence) versus data-based (best-fit distributions and correlations) assumptions.
A simulation on coevolution between language and multiple cognitive abilities
Authors: Gong Tao , Shuai Lan , Yang Xiaolong 
Published: January 2022

AbstractWe propose a coevolution scenario between language and two cognitive abilities, namely shared intentionality and lexical memory, under a conceptual framework that integrates biological evolution of language learners and cultural evolution of communal language among language users. Piggybacking on a well-attested agent-based model on the origin of simple lexicon and constituent word order out of holistic utterances, we demonstrate: (1) once adopted by early hominins to handle preliminary linguistic materials, along with the origin of an evolving communal language having a high mutual understandability among language users, the initially low levels of the two cognitive abilities are boosted and get ratcheted at sufficiently high levels in language users for proficient language learning and use; (2) the socio-cultural environment is indispensable for the coevolution, and natural selection (selecting highly understandable adults to produce offspring), not cultural selection (choosing highly understandable adults to teach offspring), drives the coevolution. This work modifies existing models and theories of coevolution between language and human cognition and clarifies theoretical controversies regarding the roles of natural and cultural selections on language evolution.
What’s your poison? Cyanide production regulated by a bHLH transcription factor inLotus japonicus
Authors: Rosati Viviana C 
Published: January 2022

AbstractHumans hold a love–hate relationship with cyanogenic plants. Preferentially selected for domestication due to their heightened pest resistance, they can nevertheless threaten both human and livestock health if not consumed in moderation or adequately processed. Over 20% of crops are cyanogenic due to the stable accumulation of cyanogenic glucosides (CNglcs) and, while the biochemical pathways of these specialized metabolites are known, the same cannot be said regarding their underlying molecular pathways. In a comprehensive study, Chen et al. (2022) characterized a basic helix–loop–helix (bHLH) transcription factor that is responsive to methyl jasmonate and directly induces expression of the key CNglc biosynthetic gene in the model species Lotus japonicus.
Seimei KOOLS-IFU mapping of the gas and dust distributions in Galactic planetary nebulae: the case of IC 2165
Authors: Otsuka Masaaki 
Published: January 2022

ABSTRACT
We investigated the physical and chemical properties of the gas and dust components in a carbon-rich planetary nebula (PN) IC 2165 using two-dimensional emission-line maps with superior resolution. The extinction map is generated in a self-consistent and assumption-free manner. The circumstellar gas-to-dust mass ratio (GDR) map ranges radially from 1210 in the central nebula filled with hot gas plasma to 120 near the ionization front. The determined GDR is comparable to ∼400, which is commonly adopted for carbon-rich asymptotic giant branch (AGB) stars, and ∼100 for interstellar medium. Except for the inner regions, the GDR in IC 2165 is nearly the same as in such AGB stars, indicating that most dust grains withstand the harsh radiation field without being destroyed. The gas and dust mass distributions concentrated in the equatorial plane may be related to the non-isotropic mass loss during the AGB phase and nebula shaping. The spatial distributions of electron densities/temperatures and ionic/elemental abundances were investigated herein. We determined 13 elemental abundances using point-spread-function-matched spatially integrated multiwavelength spectra extracted from the same aperture. Their values are consistent with values predicted by a theoretical model for stars of initially 1.75 M⊙ and Z = 0.003. Finally, we constructed the photoionization model using our distance measurement to be consistent with all derived quantities, including the GDR, gas and dust masses, and post-AGB evolution. Thus, we demonstrate the capability of the Kyoto Okayama Optical Low-dispersion Spectrograph with optical-fibre Integral Field Unit (KOOLS-IFU) and how the spatial variation of the gas and dust components in PNe derived from IFU observations can help understand the evolution of the circumstellar/interstellar medium.