bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune checkpoint inhibitors-associated thrombosis in patients with lung cancer and melanoma: a study of the Spanish society of medical oncology (SEOM) thrombosis and cancer group
Authors: Cánovas Manuel Sánchez , Garay David Fernández , Moran Laura Ortega , Pérez Jaime Rubio , Rubio Carlos Miguel Guirao , de Mena Miriam Lobo , Portero Berta Obispo , Castro Jesús Brenes , Lage Yolanda , Lavin Diego Cacho , Blanco Ana Belen Rupérez , de Soignie Ana Manuela Martín Fernández , Perejón Jonatan Zacarías Benoit , Colomo Laura Jiménez , Boluda Noel Blaya , Moreno Javier Bosque , Verduguez Teresa Quintanar , Garrido Carmen Rosa , Huertas Roberto Martín , Puig Carme Font i , Martín Andrés Jesús Muñoz 
Published: June 2022

Abstract
Purpose
Immune Checkpoint Inhibitors (ICI) can be associated with thrombotic events, both venous and arterial (VTE/AT). However, there is a paucity of information regarding patients in routine clinical practice.

Methods/patients
Retrospective, multicenter study promoted by the Thrombosis and Cancer Section of the Spanish Society of Medical Oncology (SEOM). Patients with melanoma and lung cancer who initiated ICI between 01/01/2015 and 31/12/2019 were recruited. Minimum follow-up was 6 months (unless it was not possible because of death). The primary objective was to calculate the incidence of ICI-associated VTE/AT and the secondary objectives included to analyze its impact on survival and to identify predictor variables for VTE/AT.

Results
665 patients with lung cancer were enrolled. The incidence of VTE/AT during follow-up was 8.4%. Median overall survival (OS) was lower in the VTE/AT group (12 months 95% CI 4.84–19.16 vs. 19 months 95% CI 16.11–21.9; p = 0.0049). Neutrophil/lymphocyte ratio (NLR) and anemia upon initiation of IT, as well as a history of thrombosis between cancer diagnosis and the start of ICI, were predictive variables for developing of VTE/AT (p < 0.05). 291 patients with melanoma were enrolled. There was a 5.8% incidence rate of VTE/AT during follow-up. Median OS was lower in the VTE/AT group (10 months 95% CI 0.0–20.27 vs. 29 months 95% CI 19.58–36.42; p = 0.034). NLR and lactate dehydrogenase (LDH) at the beginning of ICI were predictor variables for VTE/AT (p < 0.05).

Conclusions
ICI increases the risk of VTE/AT in patients with lung cancer and melanoma, which impact OS.
Let’s Play at Digging
Authors: Mateos Ana , Zorrilla-Revilla Guillermo , Rodríguez Jesús 
Published: June 2022

AbstractExtractive foraging tasks, such as digging, are broadly practiced among hunter-gatherer populations in different ecological conditions. Despite tuber-gathering tasks being widely practiced by children and adolescents, little research has focused on the physical traits associated with digging ability. Here, we assess how age and energetic expenditure affect the performance of this extractive task. Using an experimental approach, the energetic cost of digging to extract simulated tubers is evaluated in a sample of 40 urban children and adolescents of both sexes to measure the intensity of the physical effort and the influence of several anatomical variables. Digging is a moderately vigorous activity for inexperienced girls and boys from 8 to 14 years old, and it requires significant physical effort depending on strength and body size. However, extracting subterranean resources is a task that may be performed effectively without previous training. Sex-specific and age-specific differences in the net energy expenditure of digging were detected, even though both sexes exhibited similar proficiency levels when performing the task. Our results highlight that both boys and girls spend considerable energy while digging, with differences largely driven by body size and age. Other factors beyond ability and experience, such as strength and body size, may influence the proficiency of juveniles in performing certain physically intensive foraging tasks, such as gathering tubers.
Effect of early feeding practices and eating behaviors on body composition in primary school children
Authors: Omar Omneya Magdy , Massoud Mohamed Naguib , Ibrahim Afaf Gaber , Khalaf Nada Atef 
Published: June 2022

Abstract
Background
Understanding children’s feeding practices and eating behaviors is important to determine etiology of childhood obesity. This study aimed to explore the relationship between early feeding practices, eating behavior and body composition among primary school children.

Methods
The data were collected from 403 primary school children. They were administered structured questionnaire, including sociodemographic characteristics, early feeding practices and Child’s Eating Behavior Questionnaire. Anthropometric and blood pressure (BP) measurements were performed.

Results
Children with obesity and overweight showed higher food approach subscales and lower food avoidance subscales compared to a healthy and underweight child. Children who were exclusively or predominantly breast fed during the first 6 months had the lowest scores for the food approach subscales, food responsiveness (FR) and emotional overeating (EOE) and had the highest scores for the food avoidance subscales, satiety responsiveness (SR) and emotional under eating (EUE). Children who were introduced solid food after 6 months showed lower scores for FR, enjoyment of food and EOE but scored highest for SR, slowness in eating (SE) and EUE. All anthropometric measurements were positively correlated with all food approach subscales and negatively with SE, SR and food fussiness. All food approach subscales were positively correlated with BP percentiles. All food avoidance subscales were negatively correlated with both BP percentiles, except for EUE, which was negatively correlated with diastolic BP percentile only. Age, SR, SE and FR were predictors for child body mass index.

Conclusion
Early feeding practices and eating behavior are considered as prevention approaches for obesity.
Explaining consumer suspicion: insights of a vignette study on online product reviews
Authors: Kollmer Tim , Eckhardt Andreas , Reibenspiess Victoria 
Published: June 2022

AbstractAs part of the online product and service selection and purchase process, many consumers consult and rely on online product reviews. In order to persuade potential customers to buy their products, many organizations and businesses post deceptive product reviews of their own products on their own or third-party websites to their advantage. This creates consumer suspicion about the authenticity and veracity of online product reviews. To better understand how consumers’ experiences of having been deceived by deceptive online product reviews in the past and the density of deception characteristics in an online product review influence their level of suspicion about the review and, ultimately, their intention to buy the product, we conduct a 3 × 3 vignette study. Our results indicate that deceptive characteristics in online product reviews and prior encounters with deception in online marketplaces increase consumer suspicion. Furthermore, we show that preference for a specific product decreases consumer suspicion about reviews of that product. Lastly, we demonstrate that consumer suspicion towards a product decreases purchase intention.
Quality of life among out-patients with long-term indwelling urinary catheter attending Urology Clinic at a Tertiary Hospital in Northwestern Tanzania
Authors: Ndomba Asteria L. M. , Laisser Rose M. , T.Konje Eveline , Silago Vitus , Mwanga Joseph R. , Mshana Stephen E. 
Published: June 2022

Abstract
Background
This study aimed to determine quality of life (QoL) among patients living with long-term indwelling urinary catheter (IUC) at home in the Northwestern Tanzania. To the best of our knowledge for the first time in Africa, we report on quality of life for patients living with a long-term IUC at home.

Methods
This was a descriptive cross‑sectional study conducted between December 2016 and September 2017. A total of 202 out-patients aged 18 years and above living with a long-term IUC were conveniently recruited. The QoL was determined using WHOQOL‑BREF tool. Quantitative data were entered into Microsoft Excel for cleaning and coding, then into STATA software version 13.0 for analysis. Descriptive statistics were used to compute means and standard deviations for numerical variables as well as frequencies for nominal and ordinal variables. Significance of association between various variables and QoL were tested using t test with equal variances. Inferential statistics applied included an independent sample’s t‑test for comparing numerical socio-demographic variables. A P-value < 0.05 was considered statistically significant. The mean score indicating good QoL according to our study is a mean score of 50 and above. The higher the score the higher the QoL.

Results
Median age of participants was 69 (IQR 61–77) years. Majority of participants were males (195, 96.5%), married (187, 92.6%), and having primary education (116, 57.3%). Generally, the QoL was poor in all the domains: mean score for physical health being 36.67 ± 0.89, psychological 29.54 ± 0.87, social relationship 49.59 ± 1.61, and environment 26.05 ± 0.63. Married participants were slightly better under social domain 51.1 ± 1.6 than singles 31.1 ± 5.4; P-value 0.001. Those with primary education & above were slightly better in environmental domain 26.1 ± 0.7 than those with no formal education 23.5 ± 1.5; P-value 0.039.

Conclusion
QoL of participants with a long-term IUC in Northwestern Tanzania is generally poor in all domains. Those with primary education & above and the married were slightly better in environmental and social domains respectively. We recommend on the needs of improved social economic status and the importance of close follow up at home for the married participants living with long-term IUC.
SimplifyEnrichment: A Bioconductor Package for Clustering and Visualizing Functional Enrichment Results
Authors: Gu Zuguang , Hübschmann Daniel 
Published: June 2022

Abstract
Functional enrichment analysis or gene set enrichment analysis is a basic bioinformatics method that evaluates the biological importance of a list of genes of interest. However, it may produce a long list of significant terms with highly redundant information that is difficult to summarize. Current tools to simplify enrichment results by clustering them into groups either still produce redundancy between clusters or do not retain consistent term similarities within clusters. We propose a new method named binary cut for clustering similarity matrices of functional terms. Through comprehensive benchmarks on both simulated and real-world datasets, we demonstrated that binary cut could efficiently cluster functional terms into groups where terms showed consistent similarities within groups and were mutually exclusive between groups. We compared binary cut clustering on the similarity matrices obtained from different similarity measures and found that semantic similarity worked well with binary cut, while similarity matrices based on gene overlap showed less consistent patterns. We implemented the binary cut algorithm in the R package simplifyEnrichment, which additionally provides functionalities for visualizing, summarizing, and comparing the clustering. The simplifyEnrichment package and the documentation are available at https://bioconductor.org/packages/simplifyEnrichment/.
On equal-input and monotone Markov matrices
Authors: Baake Michael , Sumner Jeremy 
Published: June 2022

AbstractThe practically important classes of equal-input and of monotone Markov matrices are revisited, with special focus on embeddability, infinite divisibility, and mutual relations. Several uniqueness results for the classic Markov embedding problem are obtained in the process. To achieve our results, we need to employ various algebraic and geometric tools, including commutativity, permutation invariance, and convexity. Of particular relevance in several demarcation results are Markov matrices that are idempotents.
Normal Approximation for Functions of Hidden Markov Models
Authors: Houdré Christian , Kerchev George 
Published: June 2022

AbstractThe generalized perturbative approach is an all-purpose variant of Stein’s method used to obtain rates of normal approximation. Originally developed for functions of independent random variables, this method is here extended to functions of the realization of a hidden Markov model. In this dependent setting, rates of convergence are provided in some applications, leading, in each instance, to an extra log-factor vis-à-vis the rate in the independent case.
Limit theorems for continuous-state branching processes with immigration
Authors: Foucart Clément , Ma Chunhua , Yuan Linglong 
Published: June 2022

AbstractA continuous-state branching process with immigration having branching mechanism$\Psi$and immigration mechanism$\Phi$, a CBI$(\Psi,\Phi)$process for short, may have either of two different asymptotic regimes, depending on whether$\int_{0}\frac{\Phi(u)}{|\Psi(u)|}\textrm{d} u<\infty$or$\int_{0}\frac{\Phi(u)}{|\Psi(u)|}\textrm{d} u=\infty$. When$\int_{0}\frac{\Phi(u)}{|\Psi(u)|}\textrm{d} u<\infty$, the CBI process has either a limit distribution or a growth rate dictated by the branching dynamics. When$\scriptstyle\int_{0}\tfrac{\Phi(u)}{|\Psi(u)|}\textrm{d} u=\infty$, immigration overwhelms branching dynamics. Asymptotics in the latter case are studied via a nonlinear time-dependent renormalization in law. Three regimes of weak convergence are exhibited. Processes with critical branching mechanisms subject to a regular variation assumption are studied. This article proves and extends results stated by M. Pinsky in ‘Limit theorems for continuous state branching processes with immigration’ (Bull. Amer. Math. Soc.78, 1972).
Redefining capabilities as drivers of adaptation, incremental change, and transformation: recognizing the importance of strategic and operational intent on performance
Authors: Paavola Lauri , Cuthbertson Richard 
Published: June 2022

AbstractPrior research has emphasized the importance of dynamic capabilities to organizational transformation. In this paper, we explore how dynamic capabilities can have varying roles in change, and only potentially create transformational outcomes. By conducting ethnographic phenomenon driven research and observing the interactions of specific customer data related capabilities over a long period of time, we relate the potential for change to the way in which capabilities' interact, and identify three different mechanisms for change. Transformation requires a disruption of existing operational capabilities, which may result from one of the three identified mechanisms. Introducing a more theoretically consistent and practical taxonomy for (dynamic) capabilities may help in resolving some of the criticisms for their unclear practical implications. Further, our findings underline the importance of studying capabilities in their networks within organizations and over time.
Existing Ethical Tensions in Xenotransplantation
Authors: Johnson L. Syd M 
Published: June 2022

AbstractThe genetic modification of pigs as a source of transplantable organs is one of several possible solutions to the chronic organ shortage. This paper describes existing ethical tensions in xenotransplantation (XTx) that argue against pursuing it. Recommendations for lifelong infectious disease surveillance and notification of close contacts of recipients are in tension with the rights of human research subjects. Parental/guardian consent for pediatric xenograft recipients is in tension with a child’s right to an open future. Individual consent to transplant is in tension with public health threats that include zoonotic diseases. XTx amplifies concerns about justice in organ transplantation and could exacerbate existing inequities. The prevention of infectious disease in source animals is in tension with the best practices of animal care and animal welfare, requiring isolation, ethologically inappropriate housing, and invasive reproductive procedures that would severely impact the well-being of intelligent social creatures like pigs.
Current trends and future perspective of designing on-chip antennas
Authors: Singh Harshavardhan , Mandal Sujit Kumar 
Published: June 2022

AbstractWith the evolution of 5G and 6G network architectures, the demand for highly compact system-on-chip-based devices with high data transfer capabilities has been increased significantly. While the advancement of very large-scale integration technology with the continuous scaling of complementary metal–oxide–semiconductor nodes put forward to integrate different functional modules of a complete system on a single IC board, the antenna being the largest component still remains outside of the chip. Integration of the antenna and other functional modules of a system on the same chip leads to produce a really compact and economical design. Though on-chip antenna (OCAs) have several other advantages and emerging applications, they have some design challenges in terms of low gain due to losses in the substrate, requirement of miniaturization at lower microwave frequencies (LMFs) (particularly, below 10 GHz), unavailability of proper design rules, etc. In this paper, analyzing the design challenges of OCAs, their current research trends and future perspective applications are discussed.
Sensitivity of Air Pollution Exposure and Disease Burden to Emission Changes in China Using Machine Learning Emulation
Authors: Conibear Luke , Reddington Carly L. , Silver Ben J. , Chen Ying , Knote Christoph , Arnold Stephen R. , Spracklen Dominick V. 
Published: June 2022

AbstractMachine learning models can emulate chemical transport models, reducing computational costs and enabling more experimentation. We developed emulators to predict annual−mean fine particulate matter (PM2.5) and ozone (O3) concentrations and their associated chronic health impacts from changes in five major emission sectors (residential, industrial, land transport, agriculture, and power generation) in China. The emulators predicted 99.9% of the variance in PM2.5 and O3 concentrations. We used these emulators to estimate how emission reductions can attain air quality targets. In 2015, we estimate that PM2.5 exposure was 47.4 μg m−3 and O3 exposure was 43.8 ppb, associated with 2,189,700 (95% uncertainty interval, 95UI: 1,948,000–2,427,300) premature deaths per year, primarily from PM2.5 exposure (98%). PM2.5 exposure and the associated disease burden were most sensitive to industry and residential emissions. We explore the sensitivity of exposure and health to different combinations of emission reductions. The National Air Quality Target (35 μg m−3) for PM2.5 concentrations can be attained nationally with emission reductions of 72% in industrial, 57% in residential, 36% in land transport, 35% in agricultural, and 33% in power generation emissions. We show that complete removal of emissions from these five sectors does not enable the attainment of the WHO Annual Guideline (5 μg m−3) due to remaining air pollution from other sources. Our work provides the first assessment of how air pollution exposure and disease burden in China varies as emissions change across these five sectors and highlights the value of emulators in air quality research.
Global Flash Drought Analysis: Uncertainties From Indicators and Datasets
Authors: Mukherjee Sourav , Mishra Ashok Kumar 
Published: June 2022

AbstractFlash Drought (FD) has garnered much attention in recent years, with significant advancements in the indicators applied for identifying these rapidly intensifying events. However, the difference in existing FD definitions and methodologies among research communities and the choice of different data sources underscores the importance of addressing the uncertainties associated with the global FD characteristics and their drivers. This study compares two key FD indicators derived based on evaporative stress ratio (ESR) and root‐zone soil‐moisture (RZSM) using three different data sources to investigate the uncertainties in global FD frequency and intensity (speed), and the influencing drivers. The results suggest that such disparities are significant in the two FD indicators across different climate regions of the globe. The results highlight varying spatial drivers of FD frequency, intensity, and their evolution, potentially linked to background aridity. Changes in precipitation, temperature, vapor pressure deficit, and soil‐temperature coupling play an important role with a cascading (concurrent) impact on the evolution of FD based on RZSM (ESR). The relationship between ESR and RZSM fails to explain most of the variance in each of these indicators specific to the FD episodes, especially in the transitional and humid climate regimes. Overall, the results highlight the necessity of more nuanced methodologies for deriving FD indicators that can efficiently couple the rapid soil‐moisture depletion rates in deeper layers with changes in atmospheric evaporative demand which has direct implications on vegetation health.
Modeling the East‐West Asymmetry of Energetic Particle Fluence in Large Solar Energetic Particle Events Using the iPATH Model
Authors: Ding Zheyi , Li Gang , Ebert Robert W. , Dayeh Maher A. , Fe‐Dueñas Adolfo Santa , Desai Mihir , Xie Hong , Gopalswamy N. , Bruno A. 
Published: June 2022

AbstractIt has been noted that in large solar energetic particle (SEP) events, the peak intensities show an East‐West asymmetry with respect to the source flare locations. Using the 2D improved Particle Acceleration and Transport in the Heliosphere (iPATH) model, we investigate the origin of this longitudinal trend. We consider multiple cases with different solar wind speeds and eruption speeds of the coronal mass ejections (CMEs) and fit the longitudinal distributions of time‐averaged fluence by symmetric/asymmetric Gaussian functions with three time intervals of 8, 24 and 48 hr after the flare onset time respectively. The simulation results are compared with a statistical study of three‐spacecraft events. We suggest that the East‐West asymmetry of SEP fluence and peak intensity can be primarily caused the combined effect of an extended shock acceleration process and the evolution of magnetic field connection to the shock front. Our simulations show that the solar wind speed and the CME speed are important factors determining the East‐West fluence asymmetry.