bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment patterns and outcomes in patients with chronic urticaria during pregnancy: Results of PREG‐CU, a UCARE study
Authors: Kocatürk Emek , Al‐Ahmad Mona , Krause Karoline , Gimenez‐Arnau Ana M. , Thomsen Simon Francis , Conlon Niall , Marsland Alexander , Savk Ekin , Criado Roberta F. , Danilycheva Inna , Fomina Daria , Godse Kiran , Khoshkhui Maryam , Gelincik Aslı , Degirmentepe Ece Nur , Demir Semra , Ensina Luis Felipe , Kasperska‐Zajac Alicja , Rudenko Michael , Valle Solange , Medina Iris , Bauer Andrea , Zhao Zuotao , Staubach Petra , Bouillet Laurence , Küçük Özlem Su , Baygül Arzu , Maurer Marcus 
Published: September 2022

AbstractBackgroundAlthough chronic urticaria (CU) is a common and primarily affects females, there is little data on how pregnancy interacts with the disease.ObjectiveTo analyse the treatment use by CU patients before, during and after pregnancy as well as outcomes of pregnancy.MethodsPREG‐CU is an international, multicentre study of the Urticaria Centers of Reference and Excellence network. Data were collected via a 47‐item‐questionnaire completed by CU patients who became pregnant during their disease course.ResultsQuestionnaires from 288 CU patients from 13 countries were analysed. During pregnancy, most patients (60%) used urticaria medication including standard‐dose second generation H1‐antihistamines (35.1%), first generation H1‐antihistamines (7.6%), high‐dose second‐generation H1‐antihistamines (5.6%) and omalizumab (5.6%). The preterm birth rate was 10.2%; rates were similar between patients who did and did not receive treatment during pregnancy (11.6% vs. 8.7%, respectively). Emergency referrals for CU and twin birth were risk factors for preterm birth. The caesarean delivery rate was 51.3%. More than 90% of new‐borns were healthy at birth. There was no link between any patient or disease characteristics or treatments and medical problems at birth.ConclusionMost CU patients used treatment during pregnancy especially second‐generation antihistamines which seem to be safe during pregnancy regardless of the trimester. The rates of preterm births and medical problems of new‐borns in CU patients were similar to population norms and not linked to treatment used during pregnancy. Emergency referrals for CU increased the risk of preterm birth and emphasize the importance of sufficient treatment to keep urticaria under control during pregnancy.
Learning curve analysis for duodenal endoscopic submucosal dissection: A single‐operator experience
Authors: Ozeki Yuichiro , Hirasawa Kingo , Sawada Atsushi , Ikeda Ryosuke , Nishio Masafumi , Fukuchi Takehide , Kobayashi Ryosuke , Sato Chiko , Maeda Shin 
Published: September 2022

AbstractBackground and AimsSuperficial duodenal epithelial tumors are emerging targets for endoscopic submucosal dissection (ESD). However, it is unknown how competence is achieved in duodenal ESD. This study aimed to elucidate the learning curve for duodenal ESD.MethodsThis retrospective observational study included 100 consecutive patients who underwent duodenal ESD by a single endoscopist between March 2014 and September 2021. The primary outcome was to define the learning curve for duodenal ESD by an endoscopist with sufficient non‐duodenal ESD experience. Cumulative sum (CUSUM) curve analysis was used to assess the learning curve in terms of procedural speed. Comparative analyses of phases identified using the CUSUM method were performed.ResultsIn total, 98 patients were included in the analysis. Evaluation of the cumulative sum curve revealed four distinct phases in the graph: phase I, cases 1–25 (learning phase); phase II, cases 26–47 (proficiency phase); phase III, cases 48–72 (mastery phase); and phase IV, cases 73–98 (after introduction of general anesthesia). The median procedural speed was significantly faster in phase II than in phase I (11.1 mm2/min vs 7.0 mm2/min, P = .002). Clinically significant intraoperative perforation tended to decrease through phase II to phase IV (22.7%, 12.0%, and 3.8% in phases II, III, and IV, respectively). Delayed perforation occurred only in phases I and II.ConclusionsDuodenal ESD requires 25 cases to gain proficiency and 50 to achieve mastery even for an endoscopist with extensive non‐duodenal ESD experience.
The global incidence of adverse events associated with fecal microbiota transplantation in children over the past 20 years: A systematic review and meta‐analysis
Authors: Wang Ji‐Gan , Liang Qing , Dou Hui‐Hong , Ou Yuan 
Published: September 2022

AbstractObjectivesTo understand the global incidence of the adverse events associated with fecal microbiota transplantation (FMT) in children over the past 20 years.MethodsWe searched PubMed, Web of Science, Embase, and three Chinese databases (CNKI, Wanfang, and Chongqing Weipu) for high‐quality articles written over the past 20 years and made selections based on the quality standard score. The study characteristics and incidences of adverse events were extracted from each article, meta‐analysis was performed using the R.3.6.3 software, and randomized‐effect or fixed‐effect meta‐analyses were used to determine the incidence of adverse events. Subgroup analysis was performed to determine heterogeneity.ResultsA total of 18 articles involving 681 children were included in the analysis. The total effective rate of FMT in children was 85.75% (95% CI: 76.23–93.15%), of which the overall efficacy of FMT for the treatment of Clostridium difficile infection was 91.22% (95% CI: 83.49–96.68%) and the overall adverse event rate was 28.86% (95% CI: 19.56–39.15%), with a mild to moderate adverse event rate of 27.72% (95% CI: 17.86–38.83%) and a severe adverse event rate of 0.90% (95% CI: 0.33–1.76%). The most common mild to moderate adverse events were as follows: bellyache, 14.02% (95% CI: 5.43–25.77%); diarrhea, 7.75% (95% CI: 2.69–15.11%); and bloating, 7.36% (95% CI: 1.79–16.28%). Other adverse events included fever, 2.34%; vomiting, 3.12%; nausea, 1.50%; hematochezia, 2.30%; anorexia, 1.94%; and fatigue, 0.03%. The only death reported was in a study from China, in which the patient died of sepsis and liver failure 4 weeks after FMT. The other serious adverse event was an immunodeficiency patient with severe hematochezia. Another study in the United States described seven serious adverse events including one death that was not considered to be related to FMT; however, they did not describe the events in detail. There was no difference in the incidence of adverse events between the upper and lower gastrointestinal tracts (OR = 0.61, 95% CI: 0.02–15.42, P = 0.76).ConclusionAdverse events related to FMT in children are mostly mild to moderate, of short duration, and self‐limiting. Therefore, the use of FMT in children is safe and worthy of widespread promotion.
Characteristics of shifting ability in children with mild intellectual disabilities: an experimental study with a task‐switching paradigm
Authors: Kitamura Y. , Okumura Y. , Shirakawa Y. , Ikeda Y. , Kita Y. 
Published: September 2022

AbstractBackgroundShifting enables flexible switch between tasks or mental sets. It is a component of the executive function that plays critical roles in human behaviour control. However, shifting ability in individuals with intellectual disability (ID) has not been well clarified because of the use of intellectually demanding tasks in previous studies. The present study invented a novel shifting task with minimal intellectual demands and aimed to clarify the characteristics of shifting in adolescents with ID.MethodsAdolescents with ID (n = 21) and chronological‐age‐matched (n = 10) and mental‐age‐matched controls (n = 33) performed a novel shifting task with simple rule switching (i.e. change in direction). Analyses focused on the switch cost or the increase in the reaction time associated with rule switching.ResultsTwo subtypes of adolescents with ID were found with respect to the switch cost: one that lacks it and another with an increased switch cost. The lack of a switch cost was unique to the subgroup adolescents with ID and was not indicated in the control group.ConclusionsThe present study indicated that shifting in adolescents with ID does not depend solely on their intellectual function and is highly heterogeneous. This finding further implies that executive functions, including shifting, must be evaluated separately from their intellectual functions.
Treatment of sensitive skin by short‐wave radiofrequency combined with intense pulsed light
Authors: Jin Tingting , Pan Lei , Zhao Ye , Wu Sufan , Sun Yi 
Published: September 2022

AbstractBackgroundSensitive skin is a widespread dermatologic condition, and no optimal treatments have been established so far.ObjectiveTo investigated the efficacy and safety of the combined therapy of short‐wave radiofrequency (SWRF) and intense pulsed light (IPL) in improving transepidermal water loss (TEWL) and facial erythema in sensitive skin patients.MethodsTwenty‐two patients with sensitive skin received the SWRF treatment once per week for 4 weeks and IPL treatment once. Digital photographs and three‐dimensional images were taken at each follow‐up. The clinical efficacy was evaluated by the improvement of sensitive scale‐10 including irritant symptoms and facial erythema. In addition, erythema area and TEWL values were measured.ResultsAll patients showed subjective and objective improvement in irritant sensations and facial erythema after treatment. The TEWL values decreased from 20.29 ± 5.97 g·h−1·m−2 at baseline to 14.70 ± 6.02 g·h−1·m−2 after SWRF treatment and 13.78 ± 4.70 g·h−1·m−2 after combined therapy (p = 0.000). The clearance of the erythema area was statistically significant, with 14.05% ± 5.71% at baseline, 9.38% ± 4.08% after SWRF treatment, and 5.73% ± 2.79% after combined therapy (p = 0.000). No adverse events were observed.ConclusionsThe combination of SWRF with IPL was effective in relieving skin irritant sensations and facial erythema of sensitive skin by repairing skin barrier function.
Partner violence surrounding divorce: A record‐linkage study of wives and their husbands
Authors: Einiö Elina , Metsä‐Simola Niina , Aaltonen Mikko , Hiltunen Elina , Martikainen Pekka 
Published: September 2022

AbstractObjectiveThis study analyzes the victimization trajectories of partner violence against women surrounding divorce, depending on whether the couple has children together.BackgroundPrior studies have found that partner violence is associated with an increased risk of divorce. No study has assessed the victimization trajectories surrounding divorce for women with and without children, although women with children may remain at higher risk of violence following divorce.MethodUsing Finnish record‐linkage data of 22,468 divorced and 333,542 continuously married women and their husbands, we used repeated‐measures logistic regression analyses to assess changes in victimization for partner violence before and after divorce. The outcomes considered were police‐reported crimes committed by husbands against their wives and hospital‐treated assault injuries recorded for wives.ResultsThe risk of crime victimization for partner assault was already elevated from 2 to 3 years before divorce, peaked in the year prior to divorce, and then mainly leveled off 1–2 years after divorce. Hospital data show that the time of the greatest risk was from 6 to 12 months before divorce, when divorce is usually filed for. Women with younger children experienced elevated risks of physical violence shortly before divorce and remained at higher risk of menace than women without children for a year after divorce.ConclusionDivorcing women committed assaults against their husbands, but these were mostly accompanied by victimization, suggesting that resistant violence was common for women as perpetrators. Women with a history of victimization need support, especially at the starts of their divorce processes.
Current classification of vascular anomalies of the head and neck
Authors: Oomen Karin P. Q. , Wreesmann Volkert B. 
Published: September 2022

AbstractVascular anomalies of the head and neck comprise a wide spectrum of phenotypically diverse lesions. Optimal diagnosis and management of these lesions are critically dependent upon establishment of uniform and well‐defined histopathologic, clinical, and radiological criteria, but these remain subject of debate. In this paper, we describe the International Society for the Study of Vascular Anomalies classification scheme, which was first published in 1996 and updated in 2014. The strength of this proposal rests on its distinction between vascular malformations and tumors, and is responsible for its wide adoption. This paradigm serves as a developing platform for diagnosis, inter‐collegial communication, and treatment, and adhering to it will help clinicians to improve the management of vascular anomalies.
Angiosarcomas of the head and neck: Impact of large data analysis on clinical management
Authors: Wreesmann Volkert B. , Oomen Karin P. , Brennan Peter A. 
Published: September 2022

AbstractAngiosarcoma is a rare but often fatal malignancy from blood and lymphatic vessels that can arise anywhere in the body and often affects the head and neck region. Although its dismal prognosis is predominantly explained by its aggressive biology, several secondary factors contribute to poor outcomes. These include a phenotypic resemblance to innocuous blood vessel lesions, which contributes to a significant degree of late diagnosis. Another important factor is the rarity of angiosarcoma, which has impaired scientific determination of its optimal treatment significantly. As a result, treatment of angiosarcomas has largely been guided by information derived from the study of sarcomas at large, themselves a highly heterogeneous group of mesenchymal cancers both from a diagnostic as well as therapeutical perspective. The Digital Revolution and resultant Information Age promise to transform the clinical management of rare cancers from a generic to a more customized approach. In this paper, we review the current understanding of head and neck angiosarcomas within the context of this process.
Regional inequality in China during its rise as a giant exporter: A value chain analysis
Authors: Duan Yuwan , Dietzenbacher Erik , Los Bart , Dai Ruochen 
Published: September 2022

AbstractChina's exports success has implications for regional income inequality, because most of its export products are manufactured in the coastal zone. We propose a value chain‐based accounting framework to quantify the contributions of exports to regional income inequality. We employ newly developed interregional input–output tables for China, which distinguish between processing export activities and ordinary export activities. We analyze the period 2002–2012, the decade during which China became the “Factory of the World.” We find that an RMB of processing exports contributed much more to regional inequality than an RMB of ordinary exports or domestic final demand. Still, changes in regional inequality (increasing in 2002–2007 and decreasing between 2007 and 2012) are much more due to rising ordinary exports in the first subperiod and the growth of domestic final demand coupled with changes in the configuration of value chains in the second.
VanG‐ and D‐Ala‐D‐Ser‐dependent peptidoglycan synthesis and vancomycin resistance in Clostridioides difficile
Authors: Belitsky Boris R. 
Published: September 2022

AbstractA Clostridioides difficile strain deficient in the ddl gene is unable to synthesize the dipeptide D‐Ala‐D‐Ala, an essential component of peptidoglycan and the target of vancomycin. We isolated spontaneous suppressors of a ∆ddl mutation that allowed cell growth in the absence of D‐Ala‐D‐Ala. The mutations caused constitutive or partly constitutive expression of the vancomycin‐inducible vanG operon responsible for the synthesis of D‐Ala‐D‐Ser, which can replace D‐Ala‐D‐Ala in peptidoglycan. The mutations mapped to the vanS or vanR genes, which regulate expression of the vanG operon. The constitutive level of vanG expression was about 10‐fold above that obtained by vancomycin induction. The incorporation of D‐Ala‐D‐Ser into peptidoglycan due to high expression of the vanG operon conferred only low‐level resistance to vancomycin, but VanG was found to synthesize D‐Ala‐D‐Ala in addition to D‐Ala‐D‐Ser. However, the same, low resistance to vancomycin was also observed in cells completely unable to synthesize D‐Ala‐D‐Ala and grown in the presence of D‐Ala‐D‐Ser. D‐Ala‐D‐Ala presence was required for efficient vancomycin induction of the vanG operon showing that vancomycin is not by itself able to activate VanS. D‐Ala‐D‐Ser, similar to D‐Ala‐D‐Ala, served as an anti‐activator of DdlR, the positive regulator of the ddl gene, thereby coupling vanG and ddl expression.
FKBP4 correlates with CD8+ T cells and lymphatic metastases in oral squamous cell carcinoma
Authors: Zhang Yamin , Wang Jin , Yu Jing , Zhu Huiyong 
Published: September 2022

AbstractObjectivesTo identify the engagement of CD8+ T cells in the lymph node metastasis (LNM) of oral squamous cell carcinoma (OSCC) and significant CD8+ T cell‐related genes regulating the LNM.Subjects and methodsTumor samples of primary OSCC patients were obtained (n = 71). CD8 expression in LNM− and LNM+ tumors were identified using tissue microarray (TMA)‐based immunohistochemistry (IHC) and compared using the Mann–Whitney U test. The LNM status, as well as the metagene expression of CD8+ T cells of OSCC patients, were obtained from The Cancer Genome Atlas (TCGA) database. Metagenes related to LNM were screened using logistic regression analyses and further identified using TMA‐based IHC.ResultsCD8 was significantly positively associated with LNM (p < 0.05). Furthermore, tumors with higher expression of FKBP4 had significantly higher LNM rate (HR: 1.63; 95% CI: 1.08 ~ 2.53; p < 0.05), which was also proven using TMA‐based IHC analysis.ConclusionCD8+ T cells might engage in the lymphatic metastases of OSCC. Among CD8+ T cell‐related genes, FKBP4 could be a promising biomarker to predict the risk of LNM of OSCC.
Is a spice missing from the recipe? The intra‐cellular localization of vanillin biosynthesis needs further investigations
Authors: Diamond A. , Barnabé S. , Desgagné‐Penix I. 
Published: September 2022

AbstractVanillin is the most popular flavor compound in the world. Substantial effort were made in the last decades to completely elucidate the metabolic pathway that leads to vanillin in plants, with some controversy reported. In V. planifolia, vanillin biosynthesis occurs in plastids or in redifferentiated‐plastids termed ‘‘phenyloplasts’’. More recently, it was shown that all enzymes required for the conversion of [14C]‐phenylalanine to [14C]‐vanillin‐glucoside are confined within that organelle. However, knowing that some of these enzymes are cytosolic or ER‐membrane bound in most plant species, it raises questions on the interpretation of data obtained from the technique used and on the true localization of the biosynthetic enzymes in V.planifolia. In addition, intense debate has emerged about the real participation of last enzyme of the pathway involving vanillin synthase (VpVAN) in the direct conversion of ferulic acid to vanillin. With the discovery of another enzyme capable of this conversion and the lack of activity of VpVAN in vitro, further disagreement emerged. One additional challenge to VpVAN being necessary and sufficient is that the transcript for this protein is abundant invarious non‐vanillin‐producing tissues of the vanilla plant. In this viewpoint, we discuss the findings surrounding the cellular‐localization and activity of enzymes of vanillin biosynthesis. This will help to further understand the pathway and urge for additional research study to resolve the debate.
President Ford, the ASALH, and the political origins of black history month
Authors: Tomsovic Phil , Preston Thomas 
Published: September 2022

AbstractIn 1976, the Association for the Study of Afro‐American Life and History (ASALH) expanded their observance of black history from a week to a month. This decision was made because of the fortuitous timing of America's bicentennial, which the ASALH saw as an ideal opportunity not only to spotlight African American history as a fundamental part of United States history and to highlight black contributions to the country but also to celebrate its founder, Carter G. Woodson, whose centennial anniversary fell on the same year. To honor the new observance, the ASALH asked President Gerald Ford to issue a proclamation. Ford agreed to honor the observance, but chose to do so by issuing a presidential message instead of a proclamation. In this article, we examine the Ford administration's handling of ASALH's request, arguing that the decisions made resulted from several competing factors, both personal and political. Ford's personal sympathy for the struggle of black Americans and his wish to be seen favorably by black voters were tempered by his desire to act cautiously due to the shifting political considerations surrounding the 1976 election.
Administration of carbetocin—a long‐acting oxytocin analogue—before sperm collection by transrectal ultrasound‐guided massage of the accessory sex glands in bucks (Capra hircus) and ibexes (Capra pyrenaica)
Authors: Ungerfeld Rodolfo , Giriboni Julia , Toledano‐Díaz Adolfo , Guerrero Madeleine , Santiago‐Moreno Julián 
Published: September 2022

AbstractTransrectal ultrasonic‐guided massage of the accessory sex glands (TUMASG) is a technique that allows collecting semen requiring few electrical stimuli or even no pulse. A long‐acting analogue of oxytocin (carbetocin, 0.1 mg) was i.v. administered before TUMASG in 10 conscious bucks (Experiment 1) and 10 anaesthetized Iberian ibexes (Experiment 2) to shorten the time of semen collection, decrease the number of electrical stimuli and/or improve the semen quality. The ejaculated volume, concentration, quality parameters and kinetics variables of the sperm were determined in fresh semen. The time length of the procedures and the number of electric pulses applied were recorded. Furthermore, stress response indicators (number of vocalizations in Experiment 1; heart and respiratory rates, rectal temperature, cortisol levels, totals proteins and neutrophil‐to‐lymphocyte ratio in Experiment 2) were documented. In bucks, the administration of carbetocin tended to shorten the time needed for semen collection but no‐showed differences in the fresh seminal quality. In the Iberian ibexes, there were no significant differences between groups in the time length of procedures or in the number of animals that ejaculated. Carbetocin administration only reduced the respiratory rate, did it modify fresh semen characteristics in ibexes. In conclusion, the administration of carbetocin did not appear as a useful tool to improve welfare during semen collection with TUMASG or semen quality in conscious bucks and anaesthetized ibexes, having only slight advantages related to the procedure.