bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three reasons why parental burnout is more prevalent in individualistic countries: A 36-country study
Authors: Roskam Isabelle , Aguiar Joyce , Akgun Ege , Arena Andrew F. , Arikan Gizem , Aunola Kaisa , Besson Eliane , Beyers Wim , Boujut Emilie , Brianda Maria Elena , Brytek-Matera Anna , Budak A. Meltem , Carbonneau Noémie , César Filipa , Chen Bin-Bin , Dorard Géraldine , Elias Luciana Carla Santos , Dunsmuir Sandra , Egorova Natalia , Favez Nicolas , Fontaine Anne-Marie , Foran Heather , Fricke Julia , Furutani Kaichiro , Gannagé Myrna , Gaspar Maria , Godbout Lucie , Goldenberg Amit , Gross James J. , Gurza Maria Ancuta , Helmy Mai , Huynh Mai Trang , Kawamoto Taishi , Lazarevic Ljiljana B. , Vigouroux Sarah Le , Lebert-Charron Astrid , Leme Vanessa , MacCann Carolyn , Manrique-Millones Denisse , Matias Marisa , Miranda-Orrego María Isabel , Miscioscia Marina , Morgades-Bamba Clara , Mousavi Seyyedeh Fatemeh , Muntean Ana , Olderbak Sally , Osman Fatumo , Oyarce-Cadiz Daniela , Pérez-Díaz Pablo A. , Petrides Konstantinos V. , Pineda-Marin Claudia , Prikhidko Alena , Ricci Ricardo T. , Salinas-Quiroz Fernando , Sarrionandia Ainize , Scola Céline , Simonelli Alessandra , Cabrera Paola Silva , Soenens Bart , Sorbring Emma , Sorkkila Matilda , Schrooyen Charlotte , Stănculescu Elena , Starchenkova Elena , Szczygiel Dorota , Tapia Javier , Tri Thi Minh Thuy , Tremblay Mélissa , Bakel Hedwig van , Verhofstadt Lesley , Wendland Jaqueline , Yotanyamaneewong Saengduean , Mikolajczak Moïra 
Published: October 2022

Abstract
Purpose The prevalence of parental burnout, a condition that has severe consequences for both parents and children, varies dramatically across countries and is highest in Western countries characterized by high individualism.
Method In this study, we examined the mediators of the relationship between individualism measured at the country level and parental burnout measured at the individual level in 36 countries (16,059 parents).
Results The results revealed three mediating mechanisms, that is, self-discrepancies between socially prescribed and actual parental selves, high agency and self-directed socialization goals, and low parental task sharing, by which individualism leads to an increased risk of burnout among parents.
Conclusion The results confirm that the three mediators under consideration are all involved, and that mediation was higher for self-discrepancies between socially prescribed and actual parental selves, then parental task sharing, and lastly self-directed socialization goals. The results provide some important indications of how to prevent parental burnout at the societal level in Western countries.
Dimethyl fumarate inhibits noncanonical pyroptosis in dental fibroblasts
Authors: Gu Fan , Wu Hailin , Huang Zhuo , Wang Fei , Yang Ruihuan , Bian Zhuan , He Miao 
Published: October 2022

Abstract
Backgound:
Pyroptosis is a type of inflammatory cell death and is related to some oral inflammatory diseases. However, how dental fibroblasts, the major cell type in inflamed pulp and periodontium, respond to pyroptotic stimuli is not fully understood. Dimethyl fumarate (DMF), a derivative of fumarate, has immunomodulatory effects and is used as an anti-inflammatory drug. However, the effects of DMF on dental fibroblasts under exposure to pyroptotic stimuli are unclear.
Methods
We used three methods (stimulation with lipopolysaccharide (LPS) plus nigericin, poly(dA:dT) transfection and LPS transfection) to induce pyroptosis in periodontal ligament fibroblasts (PDLFs) and dental pulp cells (DPCs), two types of dental fibroblasts. THP-1 cell was used as a positive control. After that, PDLFs and DPCs were treated with or without DMF before inducing pyroptosis to examine the inhibitory effect of DMF. Pyroptotic cell death was measured by lactic dehydrogenase (LDH) release assays, cell viability assays, propidium iodide (PI) staining and flow cytometry. The expression levels of cleaved gasdermin D N-terminal (GSDMD NT), caspase-1 p20, caspase-4 p31 and cleaved PARP were examined by immunoblotting. Immunofluorescence analysis was used to detect the cellular distribution of GSDMD NT.
Results
We showed that PDLFs and DPCs were more sensitive to cytoplasmic LPS-induced noncanonical pyroptosis than to canonical pyroptosis induced by stimulation with LPS priming plus nigericin or by poly(dA:dT) transfection. In addition, treatment with DMF attenuated cytoplasmic LPS-induced pyroptotic cell death in PDLFs and DPCs. Mechanistically, we demonstrated that the expression and plasma membrane translocation of GSDMD NT were inhibited in DMF-treated PDLFs and DPCs.
Conclusions
The current study indicates that dental fibroblasts are more sensitive to cytoplasmic LPS-induced noncanonical pyroptosis and that DMF treatment blocks pyroptosis in LPS-transfected dental fibroblasts by targeting GSDMD, suggesting DMF might be a promising drug for oral inflammatory diseases.
Genetic complementation fosters evolvability in complex fitness landscapes
Authors: Otero Ernesto Alejandro Segredo , Sanjuán Rafael 
Published: October 2022

Abstract
The ability of natural selection to optimize traits depends on the topology of the genotype-fitness map (fitness landscape). Epistatic interactions produce rugged fitness landscapes, where adaptation is constrained by the presence of low-fitness intermediates. Here, we used simulations to explore how evolvability in rugged fitness landscapes is influenced by genetic complementation, a process whereby different sequence variants can compensate for their deleterious mutations. We designed our model inspired by viral populations, in which genetic variants are known to interact frequently through coinfection. Our simulations indicate that genetic complementation enables a more efficient exploration of rugged fitness landscapes. Although this benefit may be undermined by genetic parasites, its overall effect on evolutionary fitness remains positive in populations that exhibit strong relatedness between interacting sequences. Similar processes could operate in contexts other than viral coinfection, such as in the evolution of ploidy.
Mafosfamide, a Cyclophosphamide Analog, Causes a Proinflammatory Response and Increased Permeability on Endothelial Cells in Vitro
Authors: Diaz-Ricart Maribel , Martinez-Sanchez Julia , Pascual-Diaz Roger , Palomo Marta , Moreno-Castaño Ana Belén , Ventosa Helena , Salas Maria , Rovira Montse , Escolar Gines , Carreras Enric 
Published: October 2022

Abstract
Post-transplantation cyclophosphamide (PTCy) has decreased GVHD incidence. Endothelial damage in allo-HCT is caused by multiple factors, including conditioning treatments and some immunosupressants, and underlies HCT-complications as GVHD. Nevertheless, the specific impact of PTCy on the endothelium remains unclear. We evaluated the effect of mafosfamide (MAF), an active Cy analog, on endothelial cells (ECs) vs. cyclosporine A (CSA), with known damaging endothelial effect. ECs were exposed to MAF and CSA to explore changes in endothelial damage markers: i) surface VCAM-1, ii) leukocyte adhesion on ECs, iii) VE-cadherin expression, iv) production of VWF, and v) activation of intracellular signaling proteins (p38MAPK, Akt). Results obtained (expressed in folds vs. controls) indicate that both compounds increased VCAM-1 expression (3.1 ± 0.3 and 2.8 ± 0.6, respectively, p < 0.01), with higher leukocyte adhesion (5.5 ± 0.6, p < 0.05, and 2.8 ± 0.4, respectively). VE-cadherin decreased with MAF (0.8 ± 0.1, p < 0.01), whereas no effect was observed with CSA. Production of VWF augmented with CSA (1.4 ± 0.1, p < 0.05), but diminished with MAF (0.9 ± 0.1, p < 0.05). p38MAPK activation occurred with both compounds, being more intense and faster with CSA. Both drugs activated Akt, with superior MAF effect at longer exposure. Therefore, the cyclophosphamide analog MAF is not exempt from a proinflammatory effect on the endothelium, though without modifying the subendothelial characteristics.
An Unusual Case Of Acute Aortic Insufficiency From A Torn Non-Coronary Cusp
Authors: Moore Carolyn , Tayeb Taher , Brewer Colton , Burnett Dak , Gupta Kamal , Daon Emmanuel 
Published: October 2022

Abstract
Background: Aortic insufficiency (AI) is a valvular heart disease leading to inadequate closure of the valve leaflets. There are many different etiologies of AI.
Case Presentation: This case addresses an unknown etiology of acute AI from a torn non-coronary aortic cusp with associated acute heart failure that was ultimately treated with an aortic valve replacement.
Conclusions: Regardless of the etiology, prompt diagnosis, stabilization, and treatment are paramount to preventing progressive heart failure.
Association between socio-economic status and non-communicable disease risk in young adults from Kenya, South Africa, and the United Kingdom
Authors: Mtintsilana Asanda , Craig Ashleigh , Mapanga Witness , Dlamini Siphiwe N , Norris Shane A 
Published: October 2022

Abstract
There is a pressing need for global health preventions to curb the escalating burden of non-communicable diseases (NCDs). Utilising multi-country study designs can improve our understanding of how socio-economic context shapes the aetiology of NCDs, and this has great potential to advance global health interventions. We examined the association between socio-economic status (SES) and NCD risk, and the potential moderating effects of smoking and alcohol intake in young adults (18-35-year-olds) from Kenya, South Africa (SA), and the United Kingdom (UK). Our study was a cross-sectional online survey that included 3000 respondents (n = 1000 per country, 50% women) conducted in April 2022. We utilised information on twelve NCDs to classify respondents as having “no condition”, “at least one condition”, and “multimorbidity” (having two or more conditions). A total household asset score was calculated and used as a proxy of SES, and subsequently categorised into quintiles (Q1-Q5; lowest-highest). Ordered logistic regression was used to test the associations between NCD risk and exposure variables. We found that a one-category increase in SES quintile was inversely associated with an increased NCD risk in the UK but was positively associated in SA and Kenya. In all countries, smoking and/or alcohol intake were positively associated with an increased NCD risk, and showed some moderating effects on the SES-NCD relationships. Specifically, in Kenya, the risk of developing NCD was more than two times higher in those in the middle (Q3) SES group (OR: 2.493; 95% CI: 1.519–4.091; p < 0.001) compared to their lowest (Q1) SES counterparts. After adjusting for smoking and alcohol, the ORs of middle (Q3) SES group changed from 2.493 to 2.241 (1.360–3.721; p = 0.002). Overall, we found that the strength and direction of SES-NCD associations differed within and between countries. This study highlights how different SES contexts shape the risk of NCDs among young adults residing in countries at different levels of economic development.
Effects of tidal volume challenge on the reliability of plethysmography variability index in hepatobiliary and pancreatic surgeries: a prospective interventional study
Authors: Salem Yasser S.M. , Botros Joseph Makram , Khalil Magdy , Algyar Mohamed Fouad , Yassin Hany Mahmoud 
Published: October 2022

Abstract
The plethysmography variability index (PVI) is a safe, non-invasive, and useful parameter for evaluating fluid responsiveness but it does not reliably predict fluid responsiveness during low tidal volume (VT) ventilation. We hypothesized that in a ‘tidal volume challenge’ with a transient increase in tidal volume from 6 to 8 ml/kg, the changes in PVI will predict fluid responsiveness. We performed a prospective interventional study in adult patients undergoing hepatobiliary pancreatic tumor resections, having continuous cardiac output monitoring, and receiving controlled low VT ventilation. We recorded the values for PVI, perfusion index, corrected flow time (FTc), index of contractility (ICON), stroke volume variation, and stroke volume index at VT of 6 ml/kg and 1 min after the VT challenge. The VT was reduced to 6 ml/kg and a fluid bolus was given to identify fluid responders. The area under the receiver operating characteristic curve (AUC) for absolute change in PVI after increasing VT from 6 to 8 ml/kg was 0.86 (p-value < 0.001) with best cut-off value 2.5% with 95% sensitivity and 68% specificity after doing the tidal volume challenge. AUC for ICON and FTc at VT 8 ml/kg were 0.72 and 0.70 with p-value 0.008 and 0.01 and best cut-off values 40.7% and 332ms respectively. Changes in PVI value obtained by transiently increasing VT are superior to PVI value measured alone for predicting fluid responsiveness during low-VT ventilation. Also, ICON and FTc can be used as good and reliable predictors of fluid responsiveness.
Enhancing the Tribological Performance of MoS2 Coatings in Humid Environments with the Addition of Bi2S3
Authors: Prieto Germán , Pilotti Bruno Adrián , Sobanski Germán , Bajos Jairo , Tuckart Walter Roberto , Dennehy Mariana 
Published: October 2022

Abstract
The present work investigates the friction and wear properties of composite Bi2S3 - MoS2 soft coatings under different humidity levels. To achieve this goal, suspensions containing different proportions of Bi2S3 and MoS2 were sprayed onto polished SAE 1010 steel substrates to generate soft lubricating coatings. The coatings were subjected to reciprocant sliding tribological tests in air at different humidity levels, between 20 and 80%. Additionally, the formation of tribofilms in dry conditions was evaluated by means of reciprocant tests with increasing total sliding distances. The resulting wear surfaces were analyzed using SEM-EDS, Raman microspectroscopy, and laser confocal microscopy. The frictional behavior of the composite coatings was more stable than that of neat ones. The addition of Bi2S3 to MoS2 greatly enhanced the durability of the coatings at all the tested humidity levels, reaching up to a 760% increase in their durabilities. This effect depended on the humidity level and the ratio between Bi2S3 and MoS2.
Celecoxib enhances the regulation of sorafenib on the expression of prognostic genes in hepatocellular carcinoma
Authors: Gu Wang , Zhang Chao 
Published: October 2022

Abstract
Background
Hepatocellular carcinoma (HCC) is a common malignant tumor. The application of sorafenib has brought good results to the treatment of HCC, but the drug resistance of sorafenib cannot be ignored. Celecoxib can enhance the efficacy of sorafenib, but its mechanism is still unclear. The main purpose of this study is to study the efficacy and related mechanism of celecoxib and sorafenib in the treatment of hepatocellular carcinoma.
Methods
The GSE45340 data set was retrieved from the Gene Expression Database (GEO), and the differentially expressed genes were obtained by GEO2R. Then, the differentially expressed genes were screened, analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), and then analyzed by Protein-Protein Interaction (PPI) network to obtain the hub genes, which were verified in TCGA database.
Results
Through the analysis of GEO2r, we got 2181 differentially expressed genes. We selected 50 of the most diverse genes for go and KEGG enrichment analysis, and obtained their main enrichment pathways. The protein-protein interaction network of 50 genes was further obtained. Thus, the relevant key genes were obtained, and twelve genes were screened. Twelve genes (MCM4, POLA1, MCM6, MCM3, RBBP4, DNA2, AP2B1, KIF11, KIF23, TUBA1B, KIF14, NUDT21) significantly related to the prognosis of HCC and the molecular pathways involved in these genes were screened, which explained how celecoxib enhanced the efficacy of sorafenib. Twelve genes were further enriched and analyzed, and their possible mechanism of action was obtained.
Conclusions
celecoxib combined with sorafenib can enhance the regulation of hepatocellular carcinoma gene and reduce the drug resistance to sorafenib, which is of great significance for the treatment of hepatocellular carcinoma.
A few 1,3,4-oxadiazole-phenothiazine based donor-acceptor systems as potential multifaceted bioactive compounds
Authors: M Remya T , M Asha T , Deepti Ayswaria , Prakash Prabha , S Baby Chakrapani P , E Shiju , Unnikrishnan P. A. 
Published: October 2022

Abstract
1,3,4-Oxadiazole pharmacophore is still considered a viable biologically active scaffold for the synthesis of more effectual and broad-spectrum antimicrobial agents. Therefore, the present study is based on five 1,3,4-oxadiazole target structures, viz, CAROT, CAROP, CARON (D-A-D-A systems) and NOPON and BOPOB (D-A-D-A-D systems) bearing various bioactive heterocyclic moieties relevant to potential biological activities. Three of the compounds, CARON, NOPON and BOPOB were assessed in-vitro for their efficacy as antimicrobial agents against gram positive (Staphylococcus aureus and Bacillus cereus) and gram negative (Escherichia coli and Klebsiella pneumonia) bacteria; and two fungi, Aspergillus niger and Candida albicans; also, as an anti-tuberculosis agent against Mycobacterium tuberculosis. Most of the tested compounds displayed promising antimicrobial activity, especially CARON which was then analyzed for the minimum inhibitory concentration (MIC) studies. Similarly, NOPON portrayed the highest anti-TB activity among the studied compounds. Consequently, to justify the detected anti-TB activity of these compounds and to recognize the binding mode and important interactions between the compounds and the ligand binding site of the potential target, these compounds were docked into the active binding site of cytochrome P450 CYP121 enzyme of Mycobacterium tuberculosis, 3G5H. The docking results were in good agreement with the result of in-vitro studies. In addition, all the five compounds were tested for their cell viability and have been investigated for cell labeling applications. To conclude, one of the target compounds, CAROT was used for the selective recognition of cyanide ion by ‘turn-off’ fluorescent sensing technique. The entire sensing activity was examined by spectrofluorometric method and MALDI spectral studies. The limit of detection obtained was 0.14 µM.
Using a multistep approach with multidisciplinary team to increase the diagnosis rate of Lynch syndrome- associated colorectal cancer after universal screening: A single-center study in Japan
Authors: Tatsuta Kyota , Sakata Mayu , Iwaizumi Moriya , Kojima Risa , Yamanaka Katsumasa , Baba Satoshi , Suzuki Katusnori , Morita Yoshifumi , Kikuchi Hirotoshi , Hiramatsu Yoshihiro , Kurachi Kiyotaka , Takeuchi Hiroya 
Published: October 2022

Abstract
Backgrounds: This study aimed to evaluate the changes in the rates of genetic counseling and genetic testing as well as the diagnosis rate of Lynch syndrome (LS)-associated colorectal cancer before and after multistep approach with multidisciplinary team in Japanese.
Methods: In September 2016, we started universal screening for LS by mismatch repair protein immunohistochemistry and prospectively collected the records. Following patient interviews, we started multistep approach with multidisciplinary team (MA) in January 2020. MA consistsof several surgeons, one genetic counselor, one medical geneticist, and several pathologists. MA is set upto compensate for patients’lack of knowledge about geneticdiseases and make case selection for elderly colorectal cancer patients with deficient mismatch repair (dMMR). MA isdesigned as a system that could be performed by a small number of medical genetic specialists. A total of 522 patients were included during the study duration, 323 and 199 patients in the pre-MA (P-MA) and MA groups, respectively.
Results: The frequency of dMMR in all patients was 10.0%. The patient interview results indicated a significant lack of patient education regarding genetic diseases. Therates of genetic counseling and genetic testing wassignificantly higher in MA group than in P-MA group (genetic counseling: MA 34.6% vs P-MA 7.7%, p = 0.04;genetic testing: MA 30.8% vs P-MA 3.8%, p = 0.02). Moreover, the diagnosis rate of LS-associated colorectal cancer was significantly higher in MA group (2.5%) than in P-MA group (0.3%) (P = 0.03). In addition, MA could be performed without problems despite the small number of medical and human genetics specialists.
Conclusions: MA has achieved appropriate pickup of suspected hereditary colorectal cancer patients and complemented the lack of knowledge about genetic diseases. The introduction of MA increased LS-associated colorectal cancer after universal screening. MA is an appropriate LS screening protocol for Japanese who lag behind in medical and human genetics education.
Nonquadratic local stabilization of T-S fuzzy systems via improved slack-variable-free relaxation technique under limited operating region
Authors: Kim Sung Hyun 
Published: October 2022

Abstract
This paper aims to investigate the problem of nonquadratic local stabilization and disturbance attenuation for Takagi-Sugeno (T-S) fuzzy systems under the limited operating region of premise variables. To derive less conservative local stabilization conditions, this paper first proposes a parameterized linear matrix inequality (PLMI) formulation method that enables both the nonquadratic Lyapunov function and the non-parallel distributed compensation (non-PDC) control scheme. Specifically, in the PLMI formulation, the time derivatives of fuzzy basis functions are addressed without any boundary assumptions and by avoiding excessive use of inequality constraints and slack variables. Moreover, an effective relaxation technique is proposed to obtain a finite set of LMIs from PLMIs in a less conservative way without extra slack variables. Finally, three examples are provided to illustrate the effectiveness of the proposed method.