bluuebunny/crossref_metadata_2025_split huggingface dataset:
Profiles and predictive value of cytokines in children with human metapneumovirus pneumonia
Authors: Xiang Wen-qing , Li Lin , Wang Bing-han , Ali Ahmed Faisal , Li Wei 
Published: December 2022

Abstract
Background
Human metapneumovirus (HMPV) is an important cause of respiratory tract infections in young children. Early innate immune response to HMPV is focused on induction of antiviral interferons (IFNs) and other pro-inflammatory cytokines that are critical for the formation of adaptive immune responses. To evaluate the predictive value of Th1/Th2 cytokines which include IL-2, IL-4, IL-6, IL-10, INF-γ and TNF-α in pneumonia caused by HMPV.

Methods
A retrospective study was performed among 59 pneumonia pediatric patients with HMPV infection and 33 healthy children as the control cohort, which was detected by the immunofluorescence assay, and the Th1/Th2 cytokines were measured by flow cytometry. 131 children infected with Influenza virus A (IVA) and 41 children infected with influenza virus B (IVB) were detected by RT-PCR assay in throat swabs.

Results
When compared with the healthy children, children who were infected with HMPV pneumonia had a significantly lower level of IL-2 (p < 0.001) and higher levels of IL-4 (p < 0.001), IL-6 (p = 0.001), IL-10 (p < 0.001), and IFN-γ (p < 0.001). Compared with patients diagnosed with IVA or IVB infection, HMPV-positive patients had significantly higher levels of IL-4 (p < 0.001 and < 0.001), IFN-γ (p < 0.001 and < 0.001), and TNF-α (p < 0.001 and 0.016). Moreover, compared with IVA patients, HMPV-positive patients had a significantly lower level of IL-6 (p = 0.033). Finally, when comparing cytokine levels among the patients with HMPV pneumonia, IL-6 and TNF-α levels were found to be significantly higher in the severe group than the mild group (p = 0.027 and 0.049). The IL-6 and TNF-α were used to differentiate between mild symptoms and severe symptoms in children diagnosed with HMPV pneumonia with an AUC of 0.678 (95% CI 0.526–0.829) and 0.658 (95% CI 0.506–0.809), respectively.

Conclusion
Our study indicated that difference in cytokine trends depending on the virus species. The levels of IL-4, TNF-α and IFN-γ were significantly distinguished in children infected with HMPV versus IVA and IVB. IL-6 and TNF-α may be helpful in assessing the severity and prognosis of HMPV infection.
Coil and n-butyl-2-cyanoacrylate migration into the stomach after TIPS for gastroesophageal variceal bleeding: a case report and literature review
Authors: Zhang Yue-Lin , Nie Chun-Hui , Zhou Tan-Yang , Zhou Guan-Hui , Zhu Tong-Yin , Chen Sheng-Qun , Wang Hong-Liang , Wang Bao-Quan , Yu Zi-Niu , Jing Li , Xia Qi , Chen Hong-Tan , Sun Jun-Hui 
Published: December 2022

Abstract
Background
Transjugular intrahepatic portosystemic shunt (TIPS) is a well-established therapeutic option for the management of variceal hemorrhage in patients with cirrhosis. The simultaneous migration of the coil and n-butyl-2-cyanoacrylate (NBCA) is an extremely rare but significant complication after TIPS. Because of its rare presentation, there are currently no definitive recommendations for the management of this condition.

Case presentation
A 46-year-old man with hepatitis B cirrhosis underwent TIPS placement for uncontrolled gastroesophageal varix (GEV) bleeding secondary to portal hypertension in August 2018. During the procedure, large GEVs were embolized using a coil and NBCA. After a year, coil and NBCA migration into the stomach was observed. Attempts to remove the coil using biopsy forceps during esophagogastroduodenoscopy failed. The patient refused further intervention on the coil to prevent further complications and received conservative therapy instead. Close surveillance with endoscopy is recommended for detecting coils and varices.

Conclusions
The present case reports an extremely rare but significant complication after TIPS, which highlights the management and follow-up recommendation for such rare complications. Our experience may provide guidance for the management of future similar cases and stimulate discussion about treatment methods of similar patients.
Two-year follow-up of KTE-X19 in patients with relapsed or refractory adult B-cell acute lymphoblastic leukemia in ZUMA-3 and its contextualization with SCHOLAR-3, an external historical control study
Authors: Shah Bijal D. , Ghobadi Armin , Oluwole Olalekan O. , Logan Aaron C. , Boissel Nicolas , Cassaday Ryan D. , Leguay Thibaut , Bishop Michael R. , Topp Max S. , Tzachanis Dimitrios , O’Dwyer Kristen M. , Arellano Martha L. , Lin Yi , Baer Maria R. , Schiller Gary J. , Park Jae H. , Subklewe Marion , Abedi Mehrdad , Minnema Monique C. , Wierda William G. , DeAngelo Daniel J. , Stiff Patrick , Jeyakumar Deepa , Dong Jinghui , Adhikary Sabina , Zhou Lang , Schuberth Petra C. , Faghmous Imi , Masouleh Behzad Kharabi , Houot Roch 
Published: December 2022

Abstract
Background
Brexucabtagene autoleucel (KTE-X19) is an autologous anti-CD19 CAR T-cell therapy approved in the USA to treat adult patients with relapsed or refractory B-precursor acute lymphoblastic leukemia (R/R B-ALL) based on ZUMA-3 study results. We report updated ZUMA-3 outcomes with longer follow-up and an extended data set along with contextualization of outcomes to historical standard of care.

Methods
Adults with R/R B-ALL received a single infusion of KTE-X19 (1 × 106 CAR T cells/kg). Long-term post hoc subgroup assessments of ZUMA-3 were conducted. Outcomes from matched patients between historical clinical trials and ZUMA-3 patients were assessed in the retrospective historical control study SCHOLAR-3.

Results
After 26.8-months median follow-up, the overall complete remission (CR) rate (CR + CR with incomplete hematological recovery) among treated patients (N = 55) in phase 2 was 71% (56% CR rate); medians for duration of remission and overall survival (OS) were 14.6 and 25.4 months, respectively. Most patients responded to KTE-X19 regardless of age or baseline bone marrow blast percentage, but less so in patients with > 75% blasts. No new safety signals were observed. Similar outcomes were observed in a pooled analysis of phase 1 and 2 patients (N = 78). In SCHOLAR-3, the median OS for treated patients from ZUMA-3 (N = 49) and matched historical controls (N = 40) was 25.4 and 5.5 months, respectively.

Conclusions
These data, representing the longest follow-up of CAR T-cell therapy in a multicenter study of adult R/R B-ALL, suggest that KTE-X19 provides a clinically meaningful survival benefit with manageable toxicity in this population.
Trial Registration: NCT02614066.
The influence of walking speed and effects of signal processing methods on the level of human gait regularity during treadmill walking
Authors: Brachman Anna , Sobota Grzegorz , Bacik Bogdan 
Published: December 2022

Abstract
Background
In recent years the use of sample entropy (SampEn) to evaluate the complexity of the locomotor system in human gait data has gained in popularity. However, it has been suggested that SampEn is sensitive to various input parameters and signal preprocessing methods. This study quantified the effects of different temporal and spatial normalization approaches and various lengths of the template vector (m) on SampEn calculations. The discriminatory ability of SampEn was studied by comparing two walking conditions.

Methods
Twenty-three participants (seven males, 55.7 ± 8.5 years, 165.7 ± 7.9 cm, 80.5 ± 16.7 kg) walked on a treadmill with preferred (Vpref) and maximum (Vmax) speed. Data were segmented and resampled (SEGM), resampled and spatially normalized (NORM), resampled and detrended (ZERO).

Results
For vertical ground reaction force (vGRF) and center of pressure in anterio-posterior direction (COPap), in both walking conditions, SampEn was generally sensitive to the vector length and not to the data processing, except for COPap in ZERO, m = 2, 4. For the COPml SampEn behaved oppositely, it was sensitive to preprocessing method and not to the m length. The regularity of COPap and vGRF in all processed signals increased in Vmax condition. For the COPml only two signals, WHOLE and ZERO, revealed increased complexity caused by more demanding walking conditions.

Conclusions
SampEn was able to discriminate between different walking conditions in all analyzed variables, but not in all signals. Depending on evaluated variable, SampEn was susceptible in different way for the m level and processing method. Hence, these should be checked and selected for each variable independently. For future studies evaluating influence of walking velocity on COP and vGRF regularity during treadmill walking it is advised to use raw time series. Furthermore, to maintain template vector which represents biological relevance it is advised to detect highest frequencies present in analyzed signals and evaluate minimal time interval which can reflect change caused by response of a neuromuscular system. During evaluating treadmill walking measured with 100 Hz sampling frequency it is recommended to adopt m from 6 to 10, when average stride time is up to about 1 s.
Efficient 3D object recognition in mobile edge environment
Authors: Song Mofei , Guo Qi 
Published: December 2022

Abstract3D object recognition has great research and application value in the fields of automatic drive, virtual reality, and commercial manufacturing. Although various deep models have been exploited and achieved remarkable results for 3D object recognition, their computational cost is too high for most mobile applications. This paper combines edge computing and 3D object recognition into a powerful and efficient framework. It consists of a cloud-based rendering stage and a terminal-based recognition stage. In the first stage, inspired by the cloud-based rendering technique, we upload the 3D object data from the mobile device to the edge cloud server for multi-view rendering. The rendering stage utilizes the powerful computing resource in the edge cloud server to generate multiple view images of the given 3D object from different views by parallel high-quality rendering. During the terminal-based recognition stage, we integrate a lightweight CNN architecture and a neural network quantization technique into a 3D object recognition model based on the multiple images rendered in the edge cloud server, which can be executed fast in the mobile device. To reduce the cost of network training, we propose a novel semi-supervised 3D deep learning method with fewer labeled samples. Experiments demonstrate that our method achieves competitive performance compared to the state-of-the-art methods with low latency running in the mobile edge environment.
Health care systems administrators perspectives on antimicrobial stewardship and infection prevention and control programs across three healthcare levels: a qualitative study
Authors: Aika Isabel Naomi , Enato Ehijie 
Published: December 2022

Abstract
Introduction
Antimicrobial stewardship (AMS) and infection prevention control (IPC) programs are proposed to address antimicrobial resistance. Nigeria’s 5-years action plan for these programs is expiring by 2022. The objective of this study was to examine the perspectives, barriers and facilitators of these programs among health care managers and the current state of these programs in the three levels of healthcare facilities in Benin City, Nigeria.

Methods
Fourteen in-depth interviews were conducted among hospital manager across primary, secondary and tertiary healthcare facilities. The interviews were guided by semi-structured questionnaire. Responses were audio-taped and hand written. Data were analyzed by transcribing recorded tapes into major themes.

Results
Most of the participants viewed inappropriate prescribing as a problem both in the country and their facilities. None of the institutions have a formal AMS program, but participants believed that the presence of drug and therapeutic committee is a foundation for such programme. Majority of the participants acknowledged barriers to AMS to include lack of management backing, interprofessional rivalry, and poor laboratories. Only the tertiary institution has a formal IPC program. Some challenges to IPC across the healthcare institutions are inadequate waste disposal, lack of personal protective equipment and behavioral change among healthcare providers.

Conclusion
There is no AMS program across all facilities studied, although some forms of IPC activities are present in all healthcare institutions, only the tertiary facility has a formal IPC program. Effort should be made to strengthen AMS and IPC in the study facilities.
Antibiotic resistance pattern of microorganisms causing urinary tract infection: a 10-year comparative analysis in a tertiary care hospital of Bangladesh
Authors: Majumder Md. Mahabubul Islam , Mahadi Ashrafur Rahaman , Ahmed Tareq , Ahmed Mostaque , Uddin Mohammad Nazim , Alam Md. Zahirul 
Published: December 2022

AbstractBackgroundAntimicrobial resistance is an emerging concern globally in recent years. Management of common infectious diseases like urinary tract infection (UTI) has become challenging. In this context, the purpose of this study is to compare the shifting trends in bacteriology and antibiotic resistance pattern among uropathogens to similar studies conducted at various times in Bangladesh.MethodsIt was a cross-sectional study conducted at the CUMILLA MEDICAL COLLEGE HOSPITAL’S MEDICINE DEPARTMENT in three phases (2011, 2016, 2021. Patients who visited the outpatient and inpatient departments of the study center with symptoms suggestive of a urinary tract infection were undergone urine culture. Those who yielded positive growth in urne culture were finally included in the study.ResultsEscherichia coli(62% in 2021, 86% in 2016 and 76% in 2011) andKlebsiella species(11% in 2021, 10% in 2016 and 11% in 2011) were the most frequently isolated bacteria. Overall, in Gram-negative organisms, resistance was almost > 50% to all the tested antibiotics. Very high frequency of resistance ranging from 66.67 to 93.75% to cotrimoxazole, ciprofloxacin, cefuroxime, cephradine, amoxicillin and nalidixic acid, moderately high resistance to ceftriaxone (64.52%) and gentamicin (53.13%) and low resistance to nitrofurantoin (25.38%) were shown by the most commonly isolated organisms. Resistance to common antibiotics has been significantly increased over time in the isolated orgnaisms, especially in carbapenem and aminoglycoside group.ConclusionResistance of uropathogens against conventional antibiotics used to treat UTI is high and the proportion has been increased over time. The situation might be grave in upcoming years if rational consumption of antibiotics is not warranted.
Lung sparing and ribcage coverage in total body irradiation delivered by helical tomotherapy
Authors: Köksal Mümtaz , Baumert Jonathan , Schoroth Felix , Scafa Davide , Koch David , Leitzen Christina , Sarria Gustavo R. , Giordano Frank A. , Chatzikonstantinou Georgios , Schmeel Leonard C. 
Published: December 2022

Abstract
Purpose
Helical tomotherapy (HT) is a viable method for delivering total body irradiation (TBI) when preparing patients for allogenic stem cell or bone-marrow transplantation. TBI can be planned to reduce the amount of radiation delivered to organs at risk, such as the lungs, with the aim of decreasing toxicity. However, it is important for the ribcage to receive the prescribed radiation dose in preparation for bone-marrow transplantation. In this retrospective study, we analyzed radiation dose coverage of the lungs and ribcage in patients who underwent TBI delivered by HT to achieve lung dose sparing.

Methods
Thirty-five patients were included in the analysis and divided into three groups based on their prescribed radiation dose (4, 8, or 12 Gy). HT was performed using a rotating gantry to reduce radiation to the lungs. Dosimetric parameters for the lungs and ribcage as well as dose-volume histograms were calculated.

Results
The mean lung D95 was 60.97%, 54.77%, and 37.44% of the prescribed dose for patients receiving 4 Gy, 8 Gy, and 12 Gy, respectively. Ribcage coverage was most optimal for patients receiving 4 Gy, with a D95 of 91.27% and mean homogeneity index of 1.17, whereas patients receiving 12 Gy had a mean D95 of 78.65% and homogeneity index of 1.37, which is still within the range recommended by treatment guidelines.

Conclusions
Using HT to achieve lung tissue sparing is a viable approach to minimizing pulmonic complications in patients undergoing TBI. As this planning adjustment does not compromise the dose and quality of coverage received by the ribcage, it is a feasible tool within conditioning regimens for allogeneic bone-marrow transplantation.
A behavior and physiology-based decision support tool to predict thermal comfort and stress in non-pregnant, mid-gestation, and late-gestation sows
Authors: McConn Betty R. , Schinckel Allan P. , Robbins Lindsey , Gaskill Brianna N. , Green-Miller Angela R. , Lay Donald C. , Johnson Jay S. 
Published: December 2022

AbstractBackgroundAlthough thermal indices have been proposed for swine, none to our knowledge differentiate by reproductive stage or predict thermal comfort using behavioral and physiological data. The study objective was to develop a behavior and physiology-based decision support tool to predict thermal comfort and stress in multiparous (3.28 ± 0.81) non-pregnant (n = 11), mid-gestation (n = 13), and late-gestation (n = 12) sows.ResultsRegression analyses were performed using PROC MIXED in SAS 9.4 to determine the optimal environmental indicator [dry bulb temperature (TDB) and dew point] of heat stress (HS) in non-pregnant, mid-gestation, and late-gestation sows with respiration rate (RR) and body temperature (TB) successively used as the dependent variable in a cubic function. A linear relationship was observed for skin temperature (TS) indicating that TDBrather than the sow HS response impacted TSand so TSwas excluded from further analyses. Reproductive stage was significant for all analyses (P < 0.05). Heat stress thresholds for each reproductive stage were calculated using the inflections points of RR for mild HS and TBfor moderate and severe HS. Mild HS inflection points differed for non-pregnant, mid-gestation, and late gestation sows and occurred at 25.5, 25.1, and 24.0 °C, respectively. Moderate HS inflection points differed for non-pregnant, mid-gestation, and late gestation sows and occurred at 28.1, 27.8, and 25.5 °C, respectively. Severe HS inflection points were similar for non-pregnant and mid-gestation sows (32.9 °C) but differed for late-gestation sows (30.8 °C). These data were integrated with previously collected behavioral thermal preference data to estimate the TDBthat non-pregnant, mid-gestation, and late-gestation sows found to be cool (TDB < TDBpreference range), comfortable (TDB = TDBpreference range), and warm (TDBpreference range < TDB < mild HS).ConclusionsThe results of this study provide valuable information about thermal comfort and thermal stress thresholds in sows at three reproductive stages. The development of a behavior and physiology-based decision support tool to predict thermal comfort and stress in non-pregnant, mid-gestation, and late-gestation sows is expected to provide swine producers with a more accurate means of managing sow environments.
Future of work in 2050: thinking beyond the COVID-19 pandemic
Authors: Barbosa Carlos Eduardo , de Lima Yuri Oliveira , Costa Luis Felipe Coimbra , dos Santos Herbert Salazar , Lyra Alan , Argôlo Matheus , da Silva Jonathan Augusto , de Souza Jano Moreira 
Published: December 2022

AbstractWork has been continuously changing throughout history. The most severe changes to work occurred because of the industrial revolutions, and we are living in one of these moments. To allow us to address these changes as early as possible, mitigating important problems before they occur, we need to explore the future of work. As such, our purpose in this paper is to discuss the main global trends and provide a likely scenario for work in 2050 that takes into consideration the recent changes caused by the COVID-19 pandemic. The study was performed by thirteen researchers with different backgrounds divided into five topics that were analyzed individually using four future studies methods: Bibliometrics, Brainstorming, Futures Wheel, and Scenarios. As the study was done before COVID-19, seven researchers of the original group later updated the most likely scenario with new Bibliometrics and Brainstorming. Our findings include that computerization advances will further reduce the demand for low-skill and low-wage jobs; non-standard employment tends to be better regulated; new technologies will allow a transition to a personalized education process; workers will receive knowledge-intensive training, making them more adaptable to new types of jobs; self-employment and entrepreneurship will grow in the global labor market; and universal basic income would not reach its full potential, but income transfer programs will be implemented for the most vulnerable population. Finally, we highlight that this study explores the future of work in 2050 while considering the impact of the COVID-19 pandemic.
Health-Related Quality of Life in pre-dialysis patients with chronic kidney disease: the role of Big-Five personality traits and illness denial
Authors: Pugi Daniele , Ferretti Fabio , Galeazzi Maddalena , Gualtieri Giacomo , Lorenzi Lore , Pappalardo Niccolò , Macrì Pasquale Giuseppe , Garosi Guido , Coluccia Anna , Pozza Andrea 
Published: December 2022

Abstract
Background
Health-Related Quality of Life (HRQoL) in patients with chronic kidney disease (CKD) is significantly affected, regardless of the stage of the disease, as regards the physical, psychological and social functioning dimension. Big-Five personality traits can affect patients’ HRQoL and willingness to take treatment options. Illness denial consists of denial of negative emotions, resistance to change and conscious avoidance. Poorer HRQoL can predict a higher risk of hospitalization and mortality, and broadly a worse adjustment to the dialytic therapy. Thus, a clearer knowledge of the psychological variables associated with a worse HRQoL in the predialysis stage might improve the intervention planning. No study investigated illness denial and personality traits simultaneously. We investigated the role of illness denial and Big-Five personality traits in the domains of HRQoL in predialysis patients with CKD.

Methods
One hundred adults (mean age: 75.87 years) with CKD participated. The Kidney Disease Quality of Life Short form, the Italian version of Ten Item Personality Inventory Revised, the Illness Denial Questionnaire, and the State-Trait Anxiety Inventory Form-Y were administered.

Results
Illness denial was associated with increased HRQoL related to symptoms/problems, effect and burden of CKD and cognitive functions domains, and it was a predictor of higher HRQoL in the last three domains mentioned above. Extraversion was related to better work status and sexual function; agreeableness was linked to elevated cognitive function, quality of social interaction and sexual function; conscientiousness was related to better sexual function; neuroticism was linked to improved cognitive and sexual functions; in the end, openness to experience was related to fewer symptoms and problems.

Conclusions
This is the first study which simultaneously assessed Big-Five personality traits and illness denial in different domains of HRQoL of CKD patients. Personalised psychological interventions aimed at improving HRQoL in this population might focus on specific illness denial processes and personality traits.