bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of immunomodulatory therapies for patients with repeated implantation failure: a systematic review and network meta-analysis
Authors: Liu Mengqi , Yuan Yuan , Qiao Yan , Tang Yuzhu , Sui Xi , Yin Ping , Yang Dongzi 
Published: November 2022

AbstractThis meta-analysis analyzed the clinical pregnancy outcomes of repeated implantation failure (RIF) patients treated with immunomodulatory therapies. Publications (published by August 16, 2021) were identified by searching the PubMed, Embase, and Web of Science databases. The quality of the studies was evaluated with the Cochrane bias risk assessment tool, and a network meta-analysis was performed with Stata 14.0. The outcomes were clinical pregnancy rate (CPR), live birth rate (LBR), and implantation rate (IR). The results of our network meta-analysis of 16 RCTs (including 2,008 participants) show that PBMCs, PRP, and SC-GCSF can significantly improve the CPR compared with LMWH (PBMCs: OR 2.15; 95% CI 1.21–3.83; PRP: OR 2.38; 95% CI 1.08–5.24; SC-GCSF: OR 2.46; 95% CI 1.05–5.72). The LBR of PRP was significantly higher than those of IU-GCSF (OR 3.81; 95% CI 1.22–11.86), LMWH (OR 4.38; 95% CI 1.50–12.90), and intralipid (OR 3.85; 95% CI 1.03–14.29), and the LBR of PBMCs was also significantly better than that of LMWH (OR 2.35; 95% CI 1.14–4.85). Furthermore, PRP treatment significantly improved the IR compared with LMWH treatment (OR 2.81; 95% CI 1.07–7.4). The limited evidence from existing RCTs suggests that PBMCs and PRP are the best therapeutic options for RIF patients. However, owing to the quantity limitation, more top-quality research is required to obtain additional high-level evidence.
DNA read count calibration for single-molecule, long-read sequencing
Authors: Soares Luis M. M. , Hanscom Terrence , Selby Donald E. , Adjei Samuel , Wang Wei , Przybylski Dariusz , Thompson John F. 
Published: November 2022

AbstractThere are many applications in which quantitative information about DNA mixtures with different molecular lengths is important. Gene therapy vectors are much longer than can be sequenced individually via short-read NGS. However, vector preparations may contain smaller DNAs that behave differently during sequencing. We have used two library preparations each for Pacific Biosystems (PacBio) and Oxford Nanopore Technologies NGS to determine their suitability for quantitative assessment of varying sized DNAs. Equimolar length standards were generated from E. coli genomic DNA. Both PacBio library preparations provided a consistent length dependence though with a complex pattern. This method is sufficiently sensitive that differences in genomic copy number between DNA from E. coli grown in exponential and stationary phase conditions could be detected. The transposase-based Oxford Nanopore library preparation provided a predictable length dependence, but the random sequence starts caused the loss of original length information. The ligation-based approach retained length information but read frequency was more variable. Modeling of E. coli versus lambda read frequency via cubic spline smoothing showed that the shorter genome could be used as a suitable internal spike-in for DNAs in the 200 bp to 10 kb range, allowing meaningful QC to be carried out with AAV preparations.
Association between metabolic syndrome and uric acid: a systematic review and meta-analysis
Authors: Raya-Cano Elena , Vaquero-Abellán Manuel , Molina-Luque Rafael , De Pedro-Jiménez Domingo , Molina-Recio Guillermo , Romero-Saldaña Manuel 
Published: November 2022

AbstractThis systematic review and meta-analysis aim to provide the best evidence on the association between metabolic syndrome (MetS) and uric acid (UA) by determining the size of the effect of this biomarker on MetS. The review protocol is registered with PROSPERO (CRD42021231124). The search covered the PubMed and Scopus databases. Methodological quality was assessed with the STROBE tool, overall risk of bias with RevMan (Cochrane Collaboration) and quality of evidence with Grade Pro. Initially, 1582 articles were identified. Then, after excluding duplicates and reviewing titles and abstracts, 1529 articles were excluded from applying the eligibility criteria. We included 43 papers (56 groups) comparing UA concentrations between subjects 91,845 with MetS and 259,931 controls. Subjects with MetS had a higher mean UA of 0.57 mg/dl (95% CI 0.54–0.61) (p < 0.00001). Given the heterogeneity of the included studies, the researchers decided to perform subgroups analysis. Men with MetS have a higher UA concentration mg/dl 0.53 (95% CI 0.45–0.62, p < 0.00001) and women with MetS 0.57 (95% CI 0.48–0.66, p < 0.00001) compared to subjects without MetS. Assessment of UA concentration could provide a new avenue for early diagnosis of MetS, as a new biomarker and the possibility of new therapeutic targets.
Immune mobilising T cell receptors redirect polyclonal CD8+ T cells in chronic HIV infection to form immunological synapses
Authors: Wallace Zoë , Kopycinski Jakub , Yang Hongbing , McCully Michelle L. , Eggeling Christian , Chojnacki Jakub , Dorrell Lucy 
Published: November 2022

AbstractT cell exhaustion develops in human immunodeficiency virus (HIV) infection due to chronic viral antigenic stimulation. This adaptive response primarily affects virus-specific CD8+ T cells, which may remain dysfunctional despite viral load-reducing antiretroviral therapy; however, abnormalities may also be evident in non-HIV-specific populations. Both could limit the efficacy of cell therapies against viral reservoirs. Here, we show that bulk (polyclonal) CD8+ T cells from people living with HIV (PLWH) express proposed markers of dysfunctional HIV-specific T cells at high levels yet form lytic immunological synapses (IS) and eliminate primary resting infected (HIV Gaglo) CD4+ T cells, when redirected by potent bispecific T cell-retargeting molecules, Immune mobilising monoclonal T cell receptors (TCR) Against Virus (ImmTAV). While PLWH CD8+ T cells are functionally impaired when compared to CD8+ T cells from HIV-naïve donors, ImmTAV redirection enables them to eliminate Gaglo CD4+ T cells that are insensitive to autologous HIV-specific cytolytic T cells. ImmTAV molecules may therefore be able to target HIV reservoirs, which represent a major barrier to a cure.
Quantitative analysis of choroidal vasculature in central serous chorioretinopathy using ultra-widefield swept-source optical coherence tomography angiography
Authors: Zeng Qiaozhu , Yao Yuou , Tu Shu , Zhao Mingwei 
Published: November 2022

AbstractWe aimed to quantitatively compare the choroid blood flow and choroid thickness at the periphery among eyes with central serous chorioretinopathy (CSC), fellow eyes and healthy eyes using ultra-widefield swept-source optical coherence tomography angiography (UWF SS-OCTA). Retrospective analysis of 49 patients with CSC (98 eyes, including unaffected fellow eyes) and 49 age and sex matched controls were included. We obtained 3-dimensional data of vertical 20 mm × horizontal 24 mm × scan depth 6 mm, comprising 9 subfields (superotemporal, upper, superonasal, temporal, central, nasal, inferotemporal, lower, inferonasal regions). CSC eyes presented with greater density of large-vessel choroidal layer in all the 9 subfields compared with controls. Compared with normal eyes, CSC eyes had greater choroidal thickness (superotemporal, upper, superonasal, temporal, central, nasal, inferotemporal, and inferonasal subfields) and choroidal volume (superotemporal, upper, superonasal, temporal, central, and nasal subfields). Compared with control eyes, the choriocapillaris density in the superotemporal, inferotemporal and inferonasal subfields was greater in patients with CSC. Our study may provide further evidence for the congestion of vortex vein in the pathogenesis of CSC. UWF SS-OCTA can be used to evaluate the abnormalities of the choroidal structures even at the periphery in eyes with CSC.
Aggressive Lymphome (DLBCL, MCL) – was ist neu?
Authors: Silkenstedt Elisabeth , Dreyling Martin 
Published: November 2022

Was ist neu?
DLBCL. Biologie Der kürzlich publizierte „LymphGen-Algorithmus“ differenziert 7 genetische Subtypen, die sich in der Aktivierung onkogener Signalwege, im Genexpressionsmuster, im Tumormikromilieu, der Überlebenswahrscheinlichkeit und potenzieller zielgerichteter Therapien unterscheiden.
Erstlinientherapie Der Einsatz des neuen Antikörper-Wirkstoff-Konjugats Polatuzumab-Vedotin (6 Zyklen der Kombination aus Polatuzumab + R-CHP) waren der bisherigen Erstlinien-Standardtherapie mit R-CHOP hinsichtlich 2-Jahres-PFS überlegen. Subgruppenanalysen wiesen vor allem auf eine Wirksamkeit bei Patienten mit Hochrisikofaktoren hin.
Rezidivtherapie Seit Kurzem steht mit dem gegen den CD19 gerichteten Antikörper Tafasitamab in Kombination mit dem Immunmodulator Lenalidomid eine wirksame Rezidivtherapie für jene Patientengruppe zur Verfügung, die für eine Hochdosistherapie nicht geeignet ist. In 2 Phase-III-Studien wurde kürzlich bereits im 1. Rezidiv eine Überlegenheit von CAR-T-Zellen gegenüber dem bisherigen Standard der Hochdosistherapie, gefolgt von aPBSCT, gezeigt. Mit den bispezifischen, T-Zell-rekrutierenden CD3 / CD20-Antikörpern Mosunetuzumab, Epcoritamab und Glofitamab sind derzeit weitere vielversprechende immuntherapeutische Ansätze Gegenstand aktueller Phase I/II-Studien.
MCL. Biologie Trotz der weiteren Entschlüsselung des genetischen Hintergrunds des MCL ist weiterhin nur für TP53 eine klinische Relevanz nachgewiesen.
Erstlinientherapie In der Ära der zielgerichteten Therapiestrategien wird derzeit die Bedeutung des BTK-Inhibitors Ibrutinib für die Erstlinien- und Erhaltungstherapie des MCL evaluiert. Für ältere Patienten erwies sich kürzlich die Kombination des Proteasom-Inhibitors Bortezomib, Rituximab, Cyclophosphamid, Doxorubicin und Prednisolon (VR-CAP) der bisherigen Standardtherapie mit R-CHOP überlegen. Für ältere Patienten, die für intensivere Therapieregime nicht geeignet sind, führte die Erweiterung des klassischen Regimes Rituximab + Bendamustin um Ibrutinib zu einer deutlichen Verbesserung des PFS.
Rezidivtherapie Für das rezidivierte/refraktäre MCL wurden neben dem seit Jahren zugelassenen Ibrutinib kürzlich auch die beiden Next-Generation-BTK-Inhibitoren Acalabrutinib and Zanubrutinib zugelassen. Der bcl1-Inhibitor Venetoclax bietet für Hochrisikopatienten, die nach vorangegangener Therapie mit Ibrutinib ein Rezidiv erlitten, eine vielversprechende Behandlungsmöglichkeit. Bezüglich immuntherapeutischer Therapieansätze erfolgte kürzlich die Zulassung des CD19-CAR-T-Zell-Konstrukts Brexucabtagene autoleucel ab dem 2. Rezidiv.
Periphere arterielle Verschlusskrankheit bei Diabetes mellitus
Authors: Schmitt Volker H. , Keller Karsten , Espinola-Klein Christine 
Published: November 2022

Was ist neu?
Morbidität und Mortalität. Patienten mit peripherer arterieller Verschlusskrankheit (pAVK) und Diabetes mellitus stellen eine vulnerable Patientengruppe dar. Sie weisen im Vergleich zu pAVK-Patienten ohne Diabetes eine erhöhte Morbidität und eine gesteigerte Mortalität auf.
Diabetes mellitus – ein relevanter Risikofaktor für Amputationen. Das Vorliegen eines Diabetes mellitus stellt bei Menschen mit einer pAVK ein erhebliches Risiko für eine Amputation dar. Die Inzidenz von Major-Amputationen bei Diabetikern ist nach einer aktuellen Studie 10-mal und von Minor-Amputationen 15-mal höher als bei Nichtdiabetikern. Eine Amputation bei Menschen mit Diabetes mellitus hat zudem einen erheblichen Einfluss auf die Morbidität und Mortalität.
Optimierung der Patientenversorgung notwendig. Trotz großer Anstrengungen im Gesundheitssystem repräsentiert der Diabetes mellitus weiterhin einen bedeutenden Risikofaktor, auch bei Menschen mit pAVK. Unabhängig vom Vorliegen eines Diabetes mellitus wird eine pAVK wiederum bei betroffenen Menschen oftmals nicht erkannt oder nicht adäquat therapiert. Nur wenige Menschen mit pAVK werden gefäßmedizinisch betreut. Zur Reduktion von Morbidität und Mortalität sind Prävention, frühzeitige Detektion sowie eine optimale Therapie von pAVK und Diabetes mellitus allerdings essenziell.
Behandlungsstrategien bei diabetischer Nephropathie – Update 2022
Authors: Schork Anja , Artunc Ferruh 
Published: November 2022

„Was ist neu?“
Behandlungsziele bei diabetischer Nephropathie: Eine neue Einteilung von Patienten mit Diabetes mellitus in sog. Cluster kann zur Risikoeinschätzung der Entwicklung einer diabetischen Nephropathie herangezogen werden. Die Behandlung von Patienten mit diabetischer Nephropathie umfasst längst nicht mehr die reine Blutzuckerkontrolle, sondern stellt einen gesamtheitlichen Ansatz der (Progressions-) Vermeidung diabetischer Folgekomplikationen und Senkung der kardiovaskulären Mortalität des Patienten in den Mittelpunkt.
Säulen der Behandlung bei diabetischer Nephropathie: Um diese Behandlungsziele zu erreichen, benötigt es eine umfassende Betreuung des Patienten zur Umsetzung von Lebensstil-Interventionen (hinsichtlich Ernährung, körperlicher Aktivität, Gewichtsabnahme, Raucherentwöhnung) und Auswahl der medikamentösen Therapie mit dem größtmöglichen individuellen Nutzen.
Ernährungsempfehlungen bei diabetischer Nephropathie: Teil der Lebensstil-Intervention ist die Einhaltung einer Ernährungsform, die sich in aktuellen Studien erneut als relevanter Bestandteil der Progressionshemmung der chronischen Nierenerkrankung und der Senkung des kardiovaskulären Risikos erwiesen hat. Dazu gehören insbesondere eine Proteinrestriktion mit Bevorzugung pflanzlicher Proteinquellen und eine Kochsalzrestriktion.
Einsatz von medikamentösen Substanzen mit nachgewiesenem kardiorenalem Nutzen: Die Anpassung einer medikamentösen Therapie erfolgt nicht mehr nur anhand der antihyperglykämischen Effekte, sondern berücksichtigt die Progressionshemmung der Nephropathie und das kardiale Risiko sowie die Unterstützung einer Gewichtsreduktion. Hierzu stehen zusätzlich zu den RAAS-Inhibitoren aus dem Bereich der Antihypertensiva nun die Antidiabetika-Klassen der SGLT2-Inhibitoren und GLP-1-Rezeptor-Agonisten sowie der nicht steroidale Aldosteron-Antagonist Finerenon zur Verfügung.
A Case of Right Subclavian Artery Agenesis
Authors: Gooding Rose C. , Hines George L. 
Published: November 2022

AbstractThe authors present a 12-year-old male with an asymptomatic absence of the proximal right subclavian artery. On physical examination, his right brachial, radial, and ulnar pulses were diminished compared with the left side. Computed tomographic angiography revealed that the right subclavian artery was supplied from the anterior right internal mammary artery. A description of the acquired and congenital aortic arch anomalies and thoracic outlet syndrome differential diagnoses is provided.
Retrograde Type A Aortic Dissection 48 Hours after TEVAR in a Patient with a Delayed Diagnosis of Vascular Ehlers-Danlos Syndrome
Authors: Diebels Ian , Hendriks Jeroen M.H. , Durnez Joke , Paelinck Bernard P. , El Addouli Haroun , Laga Steven , Loeys Bart L. 
Published: November 2022

AbstractWe report a case of a fatal retrograde Type A aortic dissection following thoracic endovascular aortic repair (TEVAR). The patient was diagnosed with vascular Ehlers-Danlos syndrome (vEDS) only postoperatively, which is a relative contraindication for TEVAR. The patient had no major or minor criteria for vEDS. This case report emphasizes pitfalls of TEVAR in patients with a connective tissue disorder.
Unravelling the Imaging Conundrum of Rabies
Authors: Ramakrishnan Banupriya , Sivaramalingam Geethapriya , Raghavan Bagyam , Govindaraj Jayaraj 
Published: November 2022

AbstractRabies is a major disease burden worldwide, especially in Asia. Approximately, 59,000 human deaths per year occurs in over 150 countries due to rabies, with Africa and Asia contributing 95% of cases. It is a fatal infection of central nervous system (CNS) caused by rabies RNA virus via transmission through bite of an infected animal, aerosols, open wound, or organ transplantation. Magnetic resonance imaging helps in early detection of involvement of CNS and to differentiate rabies encephalitis from other conditions like Guillain-Barre syndrome, acute disseminated encephalomyelitis and other viral encephalitis.
Viscoelastic Management of Coagulopathy during the Perioperative Period of Liver Transplantation
Authors: Stewart Erin , Nydam Trevor L. , Hendrickse Adrian , Pomposelli James J. , Pomfret Elizabeth A. , Moore Hunter B. 
Published: November 2022

AbstractViscoelastic testing (VET) in liver transplantation (LT) has been used since its origin, in combination with standard laboratory testing (SLT). There are only a few, small, randomized controlled trials that demonstrated a reduction in transfusion rates using VET to guide coagulation management. Retrospective analyses contrasting VET to SLT have demonstrated mixed results, with a recent concern for overtreatment and the increase in postoperative thrombotic events. An oversight of many studies evaluating VET in LT is a single protocol that does not address the different phases of surgery, in addition to pre- and postoperative management. Furthermore, the coagulation spectrum of patients entering and exiting the operating room is diverse, as these patients can have varying anatomic and physiologic risk factors for thrombosis. A single transfusion strategy for all is short sighted. VET in combination with SLT creates the opportunity for personalized resuscitation in surgery which can address the many challenges in LT where patients are at a paradoxical risk for both life-threatening bleeding and clotting. With emerging data on the role of rebalanced coagulation in cirrhosis and hypercoagulability following LT, there are numerous potential roles in VET management of LT that have been unaddressed.
Monitoring of the heavy-ion beam distribution using poly- and monochromatic x-ray fluorescence imaging
Authors: Zähter Ş. , Rosmej O. N. , Beloiu P. , Bogdanov A. , Golubev A. , Gyrdymov M. , Jacoby J. , Kantsyrev A. , Loetzsch R. , Nicolai M. , Panyushkin V. , Skobliakov A. , Tavana P. M. , Uschmann I. , Zahn N. , Spielmann C. 
Published: November 2022

In this work, the first proof of the principal of an in situ diagnostics of the heavy-ion beam intensity distribution in irradiation of solid targets is proposed. In this scheme, x-ray fluorescence that occurs in the interaction of heavy-ions with target atoms is used for imaging purposes. The x-ray conversion to optical radiation and a transport-system was developed, and its first test was performed in experiments at the Universal Linear Accelerator in Darmstadt, Germany. The Au-beam intensity distribution on thin foils and Cu-mesh targets was imaged using multiple x-ray pinholes (polychromatic imaging) and 2D monochromatic imaging of Cu Kα radiation by using a toroidally bent silicon crystal. The presented results are of importance for application in experiments on the investigation of the equation of states of high energy density matter using high intensity GeV/u heavy-ion beams of ≥1010 particles/100 ns.
Lexical blending in terms of cognitive modeling
Authors: Peña-Cervel María Sandra 
Published: November 2022

Abstract
This corpus-based proposal provides a
fine-grained study of lexical blending in the English language in
terms of cognitive modeling. Blending as a word-formation process
has gained growing popularity in recent years either to fill certain
lexical/conceptual gaps or simply to endow language with creativity.
Blended words are defined as combinations of two or more lexemes,
one of which at least has been clipped (Bauer, 2003; Plag, 2003). Researchers of different
persuasions have addressed topics like the definition of blends,
their status as part of prosodic morphology, their scaffolding, the
recognizability of the source words making them up, their degree of
entrenchment, their lack of morphological analyzability, their
classification, and the meaning each of the source words contributes
to the resulting blend (Adams,
1973; Algeo,
1977; Bauer,
2003; Kemmer,
2003; Plag,
2003). Our corpus of analysis has been retrieved from the
online Cambridge Dictionary, consists of 715
lexical items, and covers a five-year time span, from 2016 to 2020.
The analysis of our data reveals that the most productive
word-formation process is compounding, followed by blending, which
accounts for 27.83% of our data (199 coinages). We provide evidence
of the regularity of blended words and of their principled nature by
drawing on the latest developments in cognitive modeling (Peña & Ruiz de Mendoza,
2017; Ruiz de
Mendoza, 2020; Ruiz
de Mendoza & Galera, 2014). In this connection, we
offer an in-depth study of parameterization (both metonymic and
non-metonymic), generalization, contrast, resemblance,
strengthening, expansion, and reduction as cognitive operations that
play a fundamental role in the creation and construal of blended
words.
Time-creation in film
Authors: Coëgnarts Maarten 
Published: November 2022

Abstract
This chapter aims to discuss the creation of time in cinema from an embodied cognitive perspective. Drawing on principles of Cognitive linguistics, we first discuss briefly how our ordinary thinking about time is informed by spatial knowledge. Knowing how space shapes temporal thought, we subsequently show how filmmakers may cue this spatio-temporal logic in the direction of two opposing models of time-creation in cinema: one model in which cinematic creativity serves the purpose of optimal narrative clarity, and another model in which creativity resolves around the opposite goal of spatio-temporal ambiguity. We illustrate both models through various case-examples drawn from classical narrative cinema and modern and postmodern art cinema, respectively.
Physical and imaginary landmarks in English time gestures
Authors: Alcaraz Carrión Daniel 
Published: November 2022

Abstract
In this chapter I discuss several creative instances of time co-speech gestures in English obtained from a repository of television news. I argue that, even though time gestures tend to follow certain patterns in their form, speakers may deviate, giving rise to more creative instances with a more complex meaning. The chapter begins with a brief introduction to the relation between speech and gesture, with a focus on temporal cognition, and timelines. Then, I discuss the notion of creativity in gesture research. I analyze five examples of time gestures that fall under three main categories: the ad hoc creation of imaginary timelines, the inclusion of physical items to the time construal and the emotional and pragmatic component of facial gestures.
For a prospective sociology of language
Authors: Querol Puig Ernest 
Published: November 2022

Abstract
The paper begins by defining the term prospective and goes on to analyze the studies that have been carried out “significantly, only in Catalonia” to predict the future of the Catalan language. Firstly, a critical analysis is made of ‘pseudo-prophetic’ studies – which cannot be considered prospective – that are based on an inability to contemplate a monolingual future, a dream that began with the onset of democracy. The second part of the paper deals with studies that, conversely, can be termed prospective and the third part highlights the advantages of prospective studies and suggests that they be used in language sociology, particularly in the areas of planning and language policy in order to both foresee and prevent.
The process of normalising Catalan in the media
Authors: Gifreu Josep , Corominas Maria 
Published: November 2022

Abstract
The aim of this chapter consists of an initial overall approach to the research carried out over the last 40 years on the process of normalising the Catalan Language in the conventional media (press, radio and television) and online. Firstly, it summarizes the research on the relationship between language policies and communication policies related to the processes of normalisation (“status planning”); secondly, the study of the general process of language standardisation in the media, (“corpus planning”); and, thirdly, the study of the processes and scope of implementation of Catalan in the media (extension of use).