bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluid-Attenuated Inversion Recovery Vascular Hyperintensity as a Potential Predictor for the Prognosis of Acute Stroke Patients After Intravenous Thrombolysis
Authors: Zhu Lin , Jiang Fuping , Wang Meng , Zhai Qian , Zhang Qing , Wang Feng , Mao Xuqiang , Chen Nihong , Zhou Junshan , Xi Guangjun , Shi Yachen 
Published: January 2022

BackgroundFluid-attenuated inversion recovery vascular hyperintensity (FVH) can reflect the collateral status, which may be a valuable indicator to predict the functional outcome of acute stroke (AS) patients.MethodsA total of 190 AS patients with large vessel occlusion (LVO) were retrospectively investigated. All patients completed a 6-month follow-up and their modified Rankin Scale (mRS) scores were recorded at 1, 3, and 6 months after intravenous thrombolysis (IVT). Based on their mRS at 3 months, patients were divided into two groups: poor prognosis (131 patients; 68.9% of all subjects) and favorable prognosis (59 patients; 31.1% of all subjects). The death records of 28 patients were also analyzed in the poor prognosis group.Results(1) Univariate and multivariate analyses showed that the higher National Institutes of Health Stroke Scale (NIHSS) score at admission, higher fasting blood glucose, and lower FVH score were independent risk factors to predict the poor prognosis of IVT. (2) Survival analysis indicated that FVH score was the only baseline factor to predict the 6-month survival after IVT. (3) Baseline FVH score had great prediction performance for the prognosis of IVT (area under the curve = 0.853). (4) Baseline FVH score were negatively correlated with the NIHSS score at discharge and mRS score at 1, 3, and 6 months.ConclusionAmong various baseline clinical factors, only the FVH score might have implications for 3-month outcome and 6-month survival of AS patients after IVT. Baseline FVH score showed great potential to predict the prognosis of the AS patients.
Diagnostic Performance of Extraprostatic Extension Grading System for Detection of Extraprostatic Extension in Prostate Cancer: A Diagnostic Systematic Review and Meta-Analysis
Authors: Li Wei , Shang Wenwen , Lu Feng , Sun Yuan , Tian Jun , Wu Yiman , Dong Anding 
Published: January 2022

PurposeTo evaluate the diagnostic performance of the extraprostatic extension (EPE) grading system for detection of EPE in patients with prostate cancer (PCa).Materials and MethodsWe performed a literature search of Web of Science, MEDLINE (Ovid and PubMed), Cochrane Library, EMBASE, and Google Scholar to identify eligible articles published before August 31, 2021, with no language restrictions applied. We included studies using the EPE grading system for the prediction of EPE, with histopathological results as the reference standard. The pooled sensitivity, specificity, positive likelihood ratio (LR+), negative likelihood ratio (LR−), and diagnostic odds ratio (DOR) were calculated with the bivariate model. Quality assessment of included studies was performed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool.ResultsA total of 4 studies with 1,294 patients were included in the current systematic review. The pooled sensitivity and specificity were 0.82 (95% CI 0.76–0.87) and 0.63 (95% CI 0.51–0.73), with the area under the hierarchical summary receiver operating characteristic (HSROC) curve of 0.82 (95% CI 0.79–0.85). The pooled LR+, LR−, and DOR were 2.20 (95% CI 1.70–2.86), 0.28 (95% CI 0.22–0.36), and 7.77 (95% CI 5.27–11.44), respectively. Quality assessment for included studies was high, and Deeks’s funnel plot indicated that the possibility of publication bias was low (p = 0.64).ConclusionThe EPE grading system demonstrated high sensitivity and moderate specificity, with a good inter-reader agreement. However, this scoring system needs more studies to be validated in clinical practice.
Safety Profile of Monoclonal Antibody Compared With Traditional Anticancer Drugs: An Analysis of Henan Province Spontaneous Reporting System Database
Authors: Jiao Zhiming , Wang Ganyi , Feng Zhanchun , Yan Ziqi , Zhang Jinwen , Li Gang , Wang Qianyu , Feng Da 
Published: January 2022

Introduction: Monoclonal antibody (mAb) is an important treatment option for cancer patients and has received widespread attention in recent years. In this context, a comparative safety evaluation of mAbs and traditional anticancer drugs in real-world is warranted.Methods: ADR reports submitted to Henan Adverse Drug Reaction Monitoring Center from 2016 to 2020 for individuals taking antineoplastic drugs were included. Data were analyzed with respect to demographic characteristics, disease types, polypharmacy, past history of ADRs, system organ class, name of suspected drugs per ADR report, severity, result, impact on the primary disease, and biosimilars.Results: A total of 15,910 ADR reports related to antineoplastic drugs were collected, 575 (3.61%) cases were related to mAbs. Female had more reports of ADRs than male. The ADRs of non-mAbs mainly occurred in 1–3 days after injection (4,929, 32.15%), whereas those of mAbs mainly occurred on the same day (297, 51.65%). Serious ADRs accounted for 30.26% (n = 174) of mAb-related reports and 34.46% (n = 5,285; four death cases) of non-mAb-related reports, respectively. A total of 495 (86.08%) reports were related to the branded drugs of mAbs. In general, our findings indicate that the female, the population aged 60–79 years, people with a single disease, people who have no ADRs in the past and people who have received treatment regimens were less likely to be affected by the primary disease after receiving mAbs therapy. The signal mining method produced 14 signals, only Sintilimab-Hepatic failure was off-label ADR.Conclusion: This study partly confirmed the safety profile of mAbs. It is unlikely to affect groups such as the female, the population aged 60-79 years, people with a single disease, people who have no ADRs in the past and people who have received treatment regimens. Combined drugs have little effect on the primary disease. By conducting signal mining method, 14 signals were produced, and only one of them was off-label ADR.
Activation of AMPA Receptors in the Lateral Habenula Produces Anxiolytic Effects in a Rat Model of Parkinson’s Disease
Authors: Zhang Jin , Wang Xiaobing , Bernardi Rick E. , Ju Jun , Wei Shoupeng , Gong Zhiting 
Published: January 2022

Background: Parkinson’s disease (PD) is commonly accompanied with anxiety disorder, however, the mechanisms underlying PD-mediated anxiety remain elusive. The lateral habenula (LHb) is a critical brain region that influences the activity of the monoaminergic system in the midbrain and consequently modulates anxiety. Most neurons in the LHb express AMPA receptors (AMPARs). The PD model for the pharmacological intervention of AMPA receptors was established by the unilateral lesion of the substantia nigra pars compacta (SNc) with 6-hydroxydopamine (6-OHDA).Methods: The AMPAR agonist (S)-AMPA and antagonist NBQX were microinjected into the LHb, respectively, to examine whether anxiety-like behaviors were altered in sham-operated and SNc-lesion rats, measured with the paradigms of the open-field test (OPT) and elevated plus maze (EPM). Furthermore, dopamine (DA) and 5-hydroxytryptamine (5-HT) levels in the basolateral amygdala (BLA) were measured using in vivo microdialysis immediately following the injections of (S)-AMPA and NBQX into the LHb.Results: Activation of LHb AMPA receptors by (S)-AMPA produced anxiolytic-like behaviors and enhanced the extracellular DA and 5-HT in the BLA. Conversely, NBQX induced anxiety-like effects and suppressed the extracellular DA and 5-HT in the BLA. In addition, the minimal doses inducing the effects in the SNc-lesion rats were lower than those in sham-operated rats.Conclusion: These findings suggest that the effects of AMPA receptors in the LHb on anxiety-like behaviors likely involve the extracellular levels of DA and 5-HT in the BLA. The present results may improve our understanding of the neuropathology and/or treatment of PD.
Electro-characteristics of Myocardial Pouches and Reduction of the Frequency of Steam Pops During Radiofrequency Ablation
Authors: Luo Jianfeng , Guo Fei , Zhu Hongjun , Su Hao , Wu Yuanbo , Zhu Jing , Zhang Can , Xu Jian 
Published: January 2022

Background: Radiofrequency ablation (RFA) effectively treats arrhythmia. Steam pop (SP) is a dangerous complication of RFA, which can lead to pericardial tamponade or even death.Objective: This study aimed to explore the electro-characteristics of myocardial pouches, and the relationship between SP, pouch, and impedance.Methods: Swine myocardium was divided into the pouch group and smooth myocardium group. Continuous RFA at 50 W was applied. The initial impedance reduction within the first 3 s of ablation and the time from the start of ablation to SP were recorded. After enabling the delta impedance cutoff function, RFA was performed at different percentage of delta impedance (PDI) cutoff thresholds.Results: The impedance was higher for the pouch myocardium compared to the smooth myocardium (123.22 ± 8.63 Ω and 95.75 ± 4.75 Ω, respectively; p &lt; 0.001). The RFA duration before SPs was shorter in the pouch group compared to the smooth myocardium group [9 s (interquartile range, IQR: 6.25–13 s) and 33 s (IQR: 26.25–40.75 s), respectively; p &lt; 0.001]. Within the first 3 s of RFA, impedance reduction (24.65 ± 6.57 Ω and 12.78 ± 3.35 Ω, respectively; p &lt; 0.001) and PDI [19.18% (IQR: 16.39–24.20%) and 12.96% (IQR: 11.17–14.39%), respectively; p &lt; 0.001] were greater in the pouch group compared to the smooth myocardium group. A PDI of 15% and delta time of 3 s effectively reduced the frequency of SPs without seriously affecting RFA use.Conclusion: SPs occur more frequently in the pouch area during RFA. Appropriate delta impedance cutoff settings (PDI: 15%; delta time: 3 s) can reduce the frequency of SPs and improve the RFA safety.
Positive Association Between Therapeutic Alliance and Quality of Life in Psychodynamic Psychotherapy, Cognitive Behavior Therapy, and Interpersonal Therapy: The Patient's Perspective
Authors: Barbisan Guilherme Kirsten , de Pieri Luiza Zamban , Gonçalves Leonardo , Rebouças Cinthia Danielle Vasconcelos , da Rocha Neusa Sica 
Published: January 2022

BackgroundThe therapeutic alliance (TA) is considered a common psychotherapeutic factor associated with positive results in psychotherapies. There are no studies relating the TA with quality of life (Qol).ObjectivesOur objective was to evaluate whether there is an association between the TA and Qol across three different psychotherapies.MethodsA cross-sectional study, which included outpatients undergoing individual psychotherapeutic treatment was conducted. When analyzing the total sample, the correlation of the TA with Qol domains did not present statistical significance. When considering only the sample of patients who were undergoing treatment in psychodynamic psychotherapy (PP), there was a statistically significant association between the TA and the psychological domain of Qol (p &lt; 0.05). When using a regression model for adjusting for confounding factors, the association between psychological domain with the TA on the PP patients sample lost significance (p = 0.221).DiscussionThese findings suggest that the TA seems to be more strongly related to better QoL in PP.
Mental Health of Staff at Correctional Facilities in the United States During the COVID-19 Pandemic
Authors: Burhanullah M. Haroon , Rollings-Mazza Pamela , Galecki Jeffrey , Van Wert Michael , Weber Thomas , Malik Mansoor 
Published: January 2022

BackgroundAlthough United States (US) correctional workers (correctional officers and health care workers at correctional institutions) have experienced unprecedented stress during the COVID-19 pandemic, to date, there are no systematic data on the mental health impact of COVID-19 on correctional workers.ObjectiveTo determine the perceived mental health burden of the COVID-19 pandemic on correctional workers and to explore the relationship between workers' mental health, social demographics, and environmental/work factors. In particular, the study sought to examine if occupational role (correctional officers vs. health care workers) or sex were associated with mental health status.MethodsThis cross-sectional survey was conducted in 78 correctional sites in Pennsylvania, Maryland, West Virginia and New York from November 1 to December 1, 2020. There were 589 participants, including 103 correctional officers and 486 health care workers employed at the correctional facilities. Measurements included the Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, Adult PROMIS Short Form v.1.0—Sleep Disturbance, Impact of Event Scale-Revised, Maslach Burnout Inventory 2-item, and Connor-Davidson Resilience Scale 2-item.ResultsApproximately 48% of healthcare workers and 32% of correctional officers reported mild to severe depressive symptoms, 37% reported mild to severe anxiety symptoms, 47% of healthcare workers and 57% of correctional officers reported symptoms of burnout, and 50% of healthcare workers and 45% of correctional officers reported post-traumatic stress symptoms. Approximately 18% of healthcare workers and 11% of correctional officers reports mild to moderate sleep disturbance. Health care workers had significantly higher depression and sleep disturbance scores than did correctional officers, while correctional officers had significantly higher burnout scores. Female correctional workers scored significantly higher on anxiety than their male counterparts. Increased workload, workplace conflict, younger age of employees, trust in institutional isolation practices, and lower work position were associated with increased burnout. Despite experiencing high mental health burden, correctional workers showed high resilience (60%).ConclusionWe found a high level of psychological symptoms among health care workers in correctional settings, and this population may experience unique challenges, risks and protective factors relative to other health care workers outside of correctional settings. Understanding these factors is essential for developing effective interventions for correctional workers.
Polysubstance Use Patterns Among High Dose Benzodiazepine Users: A Latent Class Analysis and Differences Between Male and Female Use
Authors: Zamboni Lorenzo , Portoghese Igor , Congiu Alessio , Zandonai Thomas , Casari Rebecca , Fusina Francesca , Bertoldi Anna , Lugoboni Fabio 
Published: January 2022

Benzodiazepines (BZDs) represent one of the most widely used groups of pharmaceuticals, but if used for long periods of time they are associated with dependence and an increased risk of harmful effects. High-dose (HD) BZD dependence is a specific substance use disorder associated with a poor quality of life. It is especially important to pinpoint differences in HD BZD addict subgroups in order to tailor treatment to the individual's specific needs, also considering possible comorbidities with other substance use disorders. We conducted a study to evaluate HD BZD dependence (converted doses to diazepam equivalents, mg) in an Italian sample of 1,354 participants. We also investigated if and to which extent participants co-used other substances (alcohol, tobacco, cannabis/cannabinoids, cocaine, and heroin). We then performed latent class analysis (LCA) to identify the use patterns of these substances, finding three classes: participants in Class 1 (4.3% of the sample) had the highest probability of also using cocaine and alcohol (Polysubstance BZD users); Class 2 comprised subjects with the highest probability of being former heroin, cocaine, THC, and alcohol users (Former polysubstance BZD users); Class 3 represented mono-dependence BZD users (78.5% of the sample) and was the most prevalent among women, while young men were most prevalent in Class 1.The present study underlines different characteristics in HD BZD users both concerning other addictions and sex, and also highlights the need for a stricter control of BZD use, ranging from prescriptions to sales.
Effect of Dexmedetomidine-Assisted Intravenous Inhalation Combined Anesthesia on Cerebral Oxygen Metabolism and Serum Th1/Th2 Level in Elderly Colorectal Cancer Patients
Authors: Tang Yixun , Liu Jitong , Huang Xiaoling , Ding Huijuan , Tan Suhong , Zhu Yimin 
Published: January 2022

ObjectiveTo observe the effect of dexmedetomidine-assisted intravenous inhalation combined anesthesia on cerebral oxygen metabolism and serum Th1/Th2 levels in elderly patients with colorectal cancer.MethodFrom April 2018 to May 2020,100 elderly patients undergoing elective laparoscopic radical resection of colorectal cancer were prospectively selected and randomly divided into observation group and control group. Before induction of anesthesia, the loading dose of dexmedetomidine was given at 0.5 μg/kg, and the infusion time was 15 min. After tracheal intubation, 0.4 μg/kg/h dexmedetomidine was continuously pumped, and the infusion was stopped 40 min before the end of the operation. In the control group, the same amount of 0.9% sodium chloride was injected intravenously in the same way. 30 min before induction of anesthesia (T0), immediately before induction of anesthesia (T1), immediately after tracheal intubation (T2), 40 min before operation (T3), and immediately after operation (T4), record the blood oxygen content of the artery and internal jugular vein Difference (D(a-jv)O2), brain oxygen uptake rate (COER%), brain oxygen saturation (rSO2) mean. VAS scale, Ramsay scale, MoCA scale were taken at 6, 12, 24, and 48 h postoperatively to evaluate analgesia, sedation, and cognitive function. And monitor the levels of interferon-γ (IFN-γ), interleukin-4 (IL-4), myelin basic protein (MBP), neuron-specific enolase (NSE) and S100β. The occurrence of restlessness and adverse reactions during the recovery period of the two groups were compared.ResultThe levels of D(a-jv)O2, COER%, and rSO2 in the control group and observation group were higher than the preoperative basic values at T2, T3, and T4 (P &lt; 0.05); The levels of D(a-jv)O2, COER%, and rSO2 in the observation group were lower than those in the control group at T2, T3, and T4 (P &lt; 0.05). The VAS score and Ramsay score of the observation group were lower than those of the control group at 6, 12, 24, and 48 h after surgery, while the MoCA score was higher than that of the control group (P &lt; 0.05). In addition, the serum IFN-γ, MBP, NSE and S100β levels of the observation group were lower than those of the control group (P &lt; 0.05), and the ratio of IFN-γ/IL-4 was higher than that of the control group (P &lt; 0.05). The overall incidence of adverse reactions in the observation group was lower than that in the control group [32.0% (16/50) vs. 12.0% (6/50), P &lt; 0.05].ConclusionDexmedetomidine-assisted combined intravenous and inhalation anesthesia is beneficial to reduce perioperative cerebral oxygen metabolism and improve postoperative immunosuppression in elderly patients with colorectal cancer. It has a certain protective effect on nerve injury after operation, thus improving the cognitive function of patients and reducing the occurrence of adverse reactions.
Hubungan antara Perceived Organizational Support dengan Organizational Commitment pada Anggota Organisasi UKKI
Authors: Fantazilu Ikhwan Fadlu , Agustin Magdalena Ayu , Dev I Gusti Ayu Agung Istri Risna Prajna 
Published: January 2022

Abstrak– This study aims to find out the relationship between perceived organizational support and organizational commitment to UKKI members. This research design was quantitative with 70 UKKI members recruited through accidental sampling technique. The data was obtained then tested first into the classical assumption test, which consists test of normality and homogeneity. Then, after the data passed the classical assumption test, the data was continued with the pearson correlation test. The results showed that there was a significant correlation between perceived organizational support and organizational commitment and the p value = 0,001 < 0,05. The implication of this research shows that in order to increase the commitment of UKKI members, UKKI must be able to provide beneficial support for its members during Covid 19 pandemic period such as by maintaining intense communication and many more.
Abstrak- Penelitian ini memiliki tujuan untuk mencari tahu hubungan antara perceived organizational support terhadap organizational commitment pada anggota UKKI. Adapun desain penelitian ini ialah kuantitatif dengan jumlah subjek sebanyak 70 orang anggota UKKI yang direkrut melalui teknik accidental sampling. Data yang diperoleh kemudian diuji terlebih dahulu ke dalam uji asumsi klasik yang terdiri atas uji normalitas dan homogenitas. Kemudian setelah data dinyatakan lolos uji asumsi klasik, data akan diolah pada uji korelasi pearson. Hasil penelitian ini menunjukkan terdapat korelasi signifikan antara perceived organizational support dengan organizational commitment dengan nilai korelasi p = 0,001 < 0,05. Implikasi dari penelitian menunjukkan bahwa untuk meningkatkan komitmen anggota UKKI, maka organisasi UKKI harus bisa menyediakan dukungan yang baik bagi anggotanya selama masa pandemi seperti dengan cara menjaga komunikasi yang intens dan lain sebagainya.
PENCEGAHAN PENYEBARAN COVID-19 (PENGGUNAAN MASKER YANG BENAR)
Authors: Suri Martha , Putri Vevi Suryenti , Feronika Feti Septia 
Published: January 2022

ABSTRAKLatar Belakang: Penggunaan masker adalah salah satu langkah pencegahan yang dapat membatasi penyebaran penyakit-penyakit saluran pernapasan tertentu yang diakibatkan oleh virus, termasuk COVID-19. Pentingnya penggunaan masker yang benar masih kurang difahami oleh masyarakat dalam pencegahan penyakit dimana potensi penularan Covid-19 jika antara penderita dan yang sehat memakai masker hanya 1,5%.Metode: Memberikan edukasi kepada warga RT.15 Kelurahan Simpang III Sipin dengan metode ceramah, tanya jawab dan demostrasi tentang cara penggunaan masker yang benar. Hasil: 15 orang (100%) warga mengalami peningkatan pengetahuan dan kesadaran menggunakan masker sebagai pencegahan terhadap corona virus-19.
Kesimpulan: Setelah dilakukan pendidikan kesehatan pada warga RT 15 Kelurahan Simpang Tiga Sipin warga mau menggunakan masker sebagai pencegahan terhadap corona virus-19.
ABSTRACT Background: The use of masks is one of the preventive measures that can limit the spread of certain respiratory diseases caused by viruses, including COVID-19. The importance of the correct use of masks is still poorly understood by the public in disease prevention where the potential for Covid-19 transmission if between sufferers and healthy people wear masks is only 1.5%. Methods: Provide education to residents of RT.15 Simpang III Sipin Village with lecture, question and answer methods and demonstrations on how to use masks correctly. Result: 15 respondents (100%) of residents experienced increased knowledge and awareness of using masks as a prevention against the corona virus-19.Conclusion: After health education was carried out for residents of RT 15 Simpang Tiga Sipin Village, residents wanted to use masks as a precaution against the corona virus-19.