bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondrial disease registries worldwide: A scoping review
Authors: Abdul-Fatah Ammanie , Esmaeilisaraji Leila , Juan Crisel Mae , Holcik Martin 
Published: October 2022

BackgroundMitochondrial diseases are a large group of genetically heterogeneous and clinically diverse disorders. Diagnosis often takes many years for which treatment may not exist. Registries are often used to conduct research, establish natural disease progression, engage the patient community, and develop best disease management practices. In Canada, there are limited centralized registries for mitochondrial disease patients, presenting a challenge for patients and professionals.ObjectiveTo support the creation of such a registry, a systematic scoping review was conducted to map the landscape of mitochondrial disease patient registries worldwide, with a focus on registry design and challenges. Furthermore, it addresses a knowledge gap by providing a narrative synthesis of published literature that describes these registries.MethodsArksey and O’Malley’s methodological framework was followed to systematically search English-language literature in PubMed and CINAHL describing the designs of mitochondrial disease patient registries, supplemented by a grey literature search. Data were extracted in Microsoft Excel. Stakeholder consultations were also performed with patient caregivers, advocates, and researchers to provide perspectives beyond those found in the literature. These data were thematically analyzed and were reported in accordance with the PRISMA-ScR reporting guidelines.ResultsA total of 17 articles were identified describing 13 unique registries located in North America, Europe, Australia, and West Asia. These papers described the registries’ designs, their strengths, and weaknesses, as well as their tangible outcomes such as facilitating recruitment for research and supporting epidemiological studies.ConclusionBased on our findings in this review, recommendations were formulated. These include establishing registry objectives, respecting patients and their roles in the registry, adopting international data standards, data evaluations, and considerations to privacy legislation, among others. These recommendations could be used to support designing a future Canadian mitochondrial disease patient registry, and to further research directly engaging these registries worldwide.
Simulation study on LDL cholesterol target attainment, treatment costs, and ASCVD events with bempedoic acid in patients at high and very-high cardiovascular risk
Authors: Katzmann Julius L. , Becker Christian , Bilitou Aikaterini , Laufs Ulrich 
Published: October 2022

Background and aims
The LDL cholesterol (LDL-C) treatment goals recommended by the 2019 ESC/EAS guidelines are only achieved in a minority of patients. The study objective was to estimate the impact of bempedoic acid treatment on LDL-C target attainment, drug costs, and atherosclerotic cardiovascular disease (ASCVD) events.
The simulation used a Monte Carlo approach in a representative cohort of German outpatients at high or very-high cardiovascular risk. Additionally to statins, consecutive treatment with ezetimibe, bempedoic acid, and a PCSK9 inhibitor was simulated in patients not achieving their LDL-C goal. Considered were scenarios without and with bempedoic acid (where bempedoic acid was replaced by a PCSK9 inhibitor when LDL-C was not controlled).

Results
The simulation cohort consisted of 105,577 patients, of whom 76,900 had very-high and 28,677 high cardiovascular risk. At baseline, 11.2% of patients achieved their risk-based LDL-C target. Sequential addition of ezetimibe and bempedoic acid resulted in target LDL-C in 33.1% and 61.9%, respectively. Treatment with bempedoic acid reduced the need for a PCSK9 inhibitor from 66.6% to 37.8% and reduced drug costs by 35.9% per year on stable lipid-lowering medication. Compared to using only statins and ezetimibe, this approach is projected to prevent additional 6,148 ASCVD events annually per 1 million patients, whereas PCSK9 inhibition alone would prevent 7,939 additional ASCVD events annually.

Conclusions
A considerably larger proportion of cardiovascular high- and very-high-risk patients can achieve guideline-recommended LDL-C goals with escalated lipid-lowering medication. Bempedoic acid is projected to substantially decrease the need for PCSK9 inhibitor treatment to achieve LDL-C targets, associated with reduced drug costs albeit with fewer prevented events.
Annona muricata L. peel extract inhibits carbohydrate metabolizing enzymes and reduces pancreatic β-cells, inflammation, and apoptosis via upregulation of PI3K/AKT genes
Authors: Ojo Oluwafemi Adeleke , Grant Susan , Amanze Jennifer Chidubem , Oni Abosede Itunuoluwa , Ojo Adebola Busola , Elebiyo Tobiloba Christiana , Obafemi Tajudeen Olabisi , Ayokunle Damilare Iyinkristi , Ogunlakin Akingbolabo Daniel 
Published: October 2022

Background and objective
Annona muricata L. peel has been recognized for many ethnobotanical uses, including diabetes management. However, limited detailed scientific information about its mechanism of antidiabetic activity exists. The objective of this study was to evaluate the anti-diabetic properties of an aqueous extract of A. muricata peel (AEAMP) and its mechanism of action on alloxan-induced diabetic rats.

Methods
In vitro antidiabetic assays, such as α-amylase and α-glucosidase were analyzed on AEAMP. Alloxan monohydrate (150 mg/kg b.w) was used to induce diabetes in the rats. 150 mg/kg b.w positive control group doses of 6.67, 13.53, and 27.06 mg/kg were administered to 3 groups for twenty-one days. The positive control group was administered 30 mg/kg of metformin. The negative and normal control groups were administered distilled water. The fasting blood glucose, serum insulin, lipid profile, inflammatory cytokines, antioxidant markers, carbohydrate metabolizing enzymes, and liver glycogen were analyzed as well as PI3K/AKT and apoptotic markers PCNA and Bcl2 by RT-PCR.

Results
AEAMP inhibited α-amylase and α-glucosidase enzymes more effectively than acarbose. AEAMP reduced FBG levels, HOMA-IR, G6P, F-1,6-BP, MDA, TG, TC, AI, CRI, IL-6, TNF-α, and NF-κB in diabetic rats. Furthermore, in diabetic rats, AEAMP improved serum insulin levels, HOMA-β, hexokinase, CAT, GST, and HDL-c. Liver PI3K, liver PCNA and pancreas PCNA were not significantly different in untreated diabetic rats when compared to normal rats suggesting alloxan induction of diabetes did not downregulate the mRNA expression of these genes. AEAMP significantly up-regulated expression of AKT and Bcl2 in the liver and pancreatic tissue. It is interesting that luteolin and resorcinol were among the constituents of AEAMP.

Conclusions
AEAMP can improve β-cell dysfunction by upregulating liver AKT and pancreatic PI3K and AKT genes, inhibiting carbohydrate metabolizing enzymes and preventing apoptosis by upregulating liver and pancreatic Bcl2. However, the potential limitation of this study is the unavailability of equipment and techniques for collecting more data for the study.
Big data network security defense mode of deep learning algorithm
Authors: Yu Yingle 
Published: October 2022

Abstract
With the rapid development and progress of big data technology, people can already use big data to judge the transmission and distribution of network information and make better decisions in time, but it also faces major network threats such as Trojan horses and viruses. Traditional network security functions generally wait until the network power is turned on to a certain extent before starting, and it is difficult to ensure the security of big data networks. To protect the network security of big data and improve its ability to defend against attacks, this article introduces the deep learning algorithm into the research of big data network security defense mode. The test results show that the introduction of deep learning algorithms into the research of network security model can enhance the security defense capability of the network by 5.12%, proactively detect, and kill cyber attacks that can pose threats. At the same time, the security defense mode will evaluate the network security of big data and analyze potential network security risks in detail, which will prevent risks before they occur and effectively protect the network security in the context of big data.
Delayed femoral vein ligation reduces operative time and blood loss during hip disarticulation in patients with extremity tumors
Authors: Yu Hongwei , Wang ShuHuai , Song Qi , You Yan , Bao Junjie , Yao Meng 
Published: October 2022

Abstract
This study aimed to evaluate the effects of delayed femoral vein ligation on the clinical outcomes of hip disarticulation. We retrospectively reviewed 20 patients with extremity tumors (10 bone tumors and 10 soft tissue sarcomas [STS]) who underwent hip disarticulation. Patients treated for hip disarticulation with synchronous femoral vein ligation (n = 10, regular surgery group) and hip disarticulation with delayed femoral vein ligation (n = 10, delayed ligation group), respectively, were enrolled in this study. The operative time and blood loss were used to evaluate the clinical outcomes. The delayed ligation group had significantly lower operative times than the regular surgery group (P < 0.05). Total, hidden, and intraoperative blood loss were all significantly lower in the delayed ligation group than in the regular surgery group (P < 0.05). However, there were no significant differences in postoperative blood loss. In conclusion, delayed femoral vein ligation could significantly reduce the operative time, hidden blood loss, and intraoperative blood loss in patients undergoing hip disarticulation.
The crystal structure of (tris(2-benzimidazolylmethyl)amine)-benzoato-copper(II) perchlorate monohydrate, CuC31H28N7O7Cl
Authors: Li Ji , Miao Mingzhi 
Published: October 2022

Abstract
CuC31H28N7O7Cl, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 10.1386(6) Å, b = 12.1155(8) Å, c = 14.1972(8) Å, α = 100.297(2)°, β = 98.411(2)°, γ = 112.744(2)°, V = 1536.78(16) Å3, Z = 2, R

gt
(F) = 0.0613, wR

ref
(F
2) = 0.1519, T = 250(2) K.
The New Girls’ Clubs: Candidate Training Programs and the Women Changing the Face of United States Politics
Authors: Carson Sarah A. 
Published: October 2022

AbstractHundreds of training and support programs for women political candidates have emerged in the United States as increasing numbers of women run for elected office. Drawing on two years of ethnographic research with Republican and Democratic programs, I outline how the groups not only provide skills training but also function as supportive social networks that propel women into leadership, toeing the line between rethinking what leadership looks like and encouraging participants to adopt entrenched practices that reflect existing gendered norms.A qualitative investigation shows that the “sisterhood” created through training is a crucial support system for alumnae, less robust but perhaps particularly important for Republican women whose party leaders and institutions are less willing to support women as an identity group. Training networks vary in the amount of support and resources they can provide, but program alumnae across the board seek to help each other socially, emotionally, and materially with advising, mentorship, volunteering, and fundraising. By helping participants band together to propel each other into elected office, women’s candidate training organizations can serve as substitutes for elite traditional fundraising and mentorship “boys’ club” networks. They are an increasingly important mechanism through which members of historically excluded communities can gain power.
Triumph and Trauma: Justifications of Mass Violence in Deuteronomistic Historiography
Authors: Markl Dominik 
Published: October 2022

AbstractThis article investigates the justifications of mass violence in Deuteronomistic historiography through the lens of cultural trauma. The analysis concentrates on the representation and justification of mass violence, that is mass killings and other forms of violence against non-combatants, in Israel’s conquest of the promised land in the books of Deuteronomy and Joshua as well as during the loss of the land at the hand of the Assyrian and Babylonian armies, as narrated in 2 Kings 17–25. A comparison of these texts and their respective historical backgrounds helps to profile the contrasts and continuities between them. Trauma theory sheds light on both narratives as media to recover agency and to reconstruct collective identity for emerging Judaism via the historiographical representation of cultural trauma.
TRADUÇÃO: OS WARAO DO DELTA DO ORINOCO: UMA CULTURA DE PALAFITEIROS
Authors: Navarro Alexandre 
Published: October 2022

A descoberta de aldeias de palafitas pré-históricas chamadas de estearias na região estuarina do estado do Maranhão, no leste do Brasil, serve de exemplo de comparação etnográfica com as aldeias de palafitas na América do Sul. Os Warao, indígenas das terras baixas do delta do Orinoco, são povos cuja adaptação cultural às várzeas das florestas tropicais inclui casas construídas sobre estacas sobre a água, além de outras estruturas. Neste artigo, apresentaremos as características da cultura Warao, registradas ao longo de mais de quatrocentos anos. Embora sua cultura às vezes seja representada como uma rara sobrevivência dos primeiros grupos de caçadores-coletores do Holoceno, as evidências corroboram para grupos de uma variação regional das maiores culturas da floresta tropical da Amazônia. Embora a aculturação forçada de missionários, fazendeiros, proprietários de serrarias e agricultores no final do século 20 tenha integrado alguns Warao às nações ocidentais, a maioria deles ainda vive em áreas úmidas de florestas ribeirinhas ou de marés, como registraram os primeiros exploradores europeus. A sociedade tradicional Warao ainda é organizada em famílias matrilocais lideradas por uma mulher mais velha, suas filhas, cônjuges e filhos. Os Warao ainda vivem a partir da exploração sazonal de frutos, amido de palmeiras cultivadas, domesticadas e selvagens, ervas, cultivo de milho e pesca. A caça da maioria dos grandes animais é tabu, mas espécies menores são consumidas e patos são domesticados. As estruturas materiais de seus assentamentos, geralmente feita de colmo, são distribuídas e construídas em plataformas elevadas sobre estacas ou no solo em diques aluviais mais altos. Pequenos edifícios rituais nos assentamentos incluem uma casa de isolamento ritual para mulheres a oeste, e, a leste, um santuário com ídolos de pedra, instrumentos rituais e um armazém para estocagem de amido de palmeiras para festivais sazonais. A rica ideologia religiosa dos Warao concentra-se nos espíritos ancestrais e deidades astronômicas de um cosmos mítico estabelecido pela primeira xamã, uma divindade chamada "Mãe da Floresta". Seu alter ego, a serpente da água, está representada nas canoas que os Warao se especializaram em fazer. Um festival anual liderado por mulheres e oficializado por sacerdotes-xamãs de ambos os sexos celebra a colheita de amido do buriti com canto, dança, festa e confecção de artesanato especial. Reconhecidos como navegadores e remadores infatigáveis, os Warao sempre comercializaram ativamente seus inúmeros produtos, desde canoas, remos, redes e cestas a pássaros domésticos, cães de caça e peixes defumados.
Musical Meter Induces Interbrain Synchronization during Interpersonal Coordination
Authors: Hu Yinying , Zhu Min , Liu Yang , Wang Zixuan , Cheng Xiaojun , Pan Yafeng , Hu Yi 
Published: October 2022

AbstractMusic induces people to coordinate with one another. Here, we conduct two experiments to examine the underlying mechanism of the interbrain synchronization (IBS) that is induced by interpersonal coordination when people are exposed to musical beat and meter. In experiment 1, brain signals at the frontal cortex were recorded simultaneously from two participants of a dyad by using functional near-infrared spectroscopy (fNIRS) hyperscanning, while each tapped their fingers to aural feedback from their partner (coordination task) or from themselves (independence task) with and without the musical meter. The results showed enhanced IBS at the left-middle frontal cortex in case of the coordination task with musical beat and meter. The IBS was significantly correlated with the participants performance in terms of coordination. In experiment 2, we further examined the IBS while the participants coordinated their behaviors in various metrical contexts, such as strong and weak meters (i.e., high/low loudness of acoustically accenting beats). The results showed that strong meters elicited higher IBS at the middle frontal cortex than weak meters. These findings reveal that the musical beat and meter can affect brain-to-brain coupling in action coordination between people, and provide insights into the interbrain mechanism underlying the effects of music on cooperation.
Phospholipid imbalance impairs autophagosome completion
Authors: Polyansky Alexandra , Shatz Oren , Fraiberg Milana , Shimoni Eyal , Dadosh Tali , Mari Muriel , Reggiori Fulvio M , Qin Chao , Han Xianlin , Elazar Zvulun 
Published: October 2022

AbstractAutophagy, a conserved eukaryotic intracellular catabolic pathway, maintains cell homeostasis by lysosomal degradation of cytosolic material engulfed in double membrane vesicles termed autophagosomes, which form upon sealing of single‐membrane cisternae called phagophores. While the role of phosphatidylinositol 3‐phosphate (PI3P) and phosphatidylethanolamine (PE) in autophagosome biogenesis is well‐studied, the roles of other phospholipids in autophagy remain rather obscure. Here we utilized budding yeast to study the contribution of phosphatidylcholine (PC) to autophagy. We reveal for the first time that genetic loss of PC biosynthesis via the CDP‐DAG pathway leads to changes in lipid composition of autophagic membranes, specifically replacement of PC by phosphatidylserine (PS). This impairs closure of the autophagic membrane and autophagic flux. Consequently, we show that choline‐dependent recovery of de novo PC biosynthesis via the CDP‐choline pathway restores autophagosome formation and autophagic flux in PC‐deficient cells. Our findings therefore implicate phospholipid metabolism in autophagosome biogenesis.
Evidence for helical microstructure of aragonite fibers in pteropod shells
Authors: Checa Antonio G. , Pimentel Carlos , Berent Katarzyna , Ramos-Silva Paula , Rodríguez-Navarro Alejandro B. , Cartwright Julyan H. E. , Sainz-Díaz Claro I. 
Published: October 2022

Abstract
Planktonic gastropods of the suborder Euthecosomata (order Pteropoda) secrete a unique microstructure made of tightly interlocked, space-filling helically coiled aragonite fibers. This material has a high degree of ordering because all fibers are in phase at a given growth plane. The recognition of the helical nature from mere scanning electron micrographs is somewhat uncertain. In addition, three-dimensional (3D) reconstructions of individual helices are hindered by the small dimensions of fibers, and the virtual absence of intervening organic interphases. Here, we (1) reexamine the morphological characteristics of the fibers in fracture and find them compatible with a helical model, (2) provide direct evidence of the helical mode of coiling in the form of anaglyphs, and (3) develop a 3D model, which is fully consistent with the patterns observed in fractures and polished sections. Proposals based on motifs different from helices are not congruent with the observations.

Graphical abstract

Impact statement
Some planktonic gastropods of the order Pteropoda secrete a unique microstructure that was originally described as made of tightly interlocked helically coiled continuous aragonite fibers. Despite this material having been described 50 years ago, there is still debate as to the helical design of such fibers. We provide additional unambiguous evidence that fibers describe true helical trajectories during growth. Establishing their true nature is essential in order to know the spectrum of calcified biomaterials produced by molluscs. This is also a prerequisite for future biomimetic studies aiming at producing bioinspired highly functional materials.
Diagnostic approach to chronic bowel diseases in children
Authors: Yaroshevska Tetiana , Skriabina Kateryna 
Published: October 2022

Diagnosing inflammatory bowel diseases in children and differentiating them from functional disorders is complicated based on clinical assessment, laboratory data, and radiological, endoscopic, and histological signs. Therefore, in paediatrics, substantial attention has been given to standard invasive evaluation methods. Recently, research efforts have been directed towards using faecal calprotectin as a sensitive non-invasive stool test.
The aim of the research was to study the diagnostic value of faecal calprotectin in pediatric chronic inflammatory bowel diseases. The paper discusses faecal calprotectin's diagnostic and monitoring role in 35 children aged 3 to 17 years with ulcerative colitis, non-specific non-ulcerative colitis, and irritable bowel syndrome. The concentration of the faecal calprotectin level was examined by ELISA using monoclonal antibodies.
Results. The study shows that in patients with non-specific ulcerative and non-ulcerative colitis, the faecal calprotectin level exceeds the normal ranges 2-5 times, corresponding to clinical and morphological manifestations of the diseases and the level of inflammatory markers. However, this biological marker does not exceed the average values in children with irritable bowel syndrome.
Conclusions. The faecal calprotectin test allows us to differentiate organic and functional intestinal diseases, monitor chronic inflammatory bowel disease activity dynamics, and estimate treatment effectiveness. Applying the faecal calprotectin test within the framework of primary medical care can decrease the number of referrals for invasive endoscopic, laboratory, and radiologic examinations in pediatric patients with inflammatory bowel diseases
A cross-sectional study of psychopathology, quality of life and caregiver burden in caregivers of cancer patients
Authors: Sanjeevani Gangaraboina , Ramakanth Paniharam , Chaitanya Adhi 
Published: October 2022

Caregivers of cancer patients were prone to deterioration of their QOL due to the caregiving burden. A high caregiving burden and low QOL were common among CG. In India, only a few studies were done on the caregivers of cancer patients. Hence this study was undertaken.
The aim: To study psychopathology, quality of life and burden in caregivers of cancer patients
Materials and methods: The study was done on 100 caregivers of cancer patients attending after fulfilling the inclusion criteria. A semi-structured Proforma was administrated to collect the socio-demographic details. Following by Mini International Neuropsychiatric Interview (MINI), WHO-QOL and Burden assessment scale was administered to the caregivers. Data were analysed using SPSS. Descriptive statistics, Pearson and Spearman Correlations and ANOVA were used.
Results: 31 % of caregivers suffer from generalised anxiety disorders (15 %) and depression (16 %). The environmental domain of QOL (mean-18.2, SD-15.4) was the most affected. 83 % of caregivers experienced a moderate burden, and 17 % had a severe burden. These variables are significantly associated with caregiver relation with patient and socio-economic status (<0.05). A significant correlation was found between Psychiatric morbidity, QOL and Burden in caregivers.
Conclusion: psychiatric morbidity, quality of life and burden in CGs influence one another. The least attention was paid to caregivers' mental health, many of them left unidentified and untreated. These results highlight the need to educate them about mental health and counsel and treat them for their psychiatric problems