bluuebunny/crossref_metadata_2025_split huggingface dataset:
Video-based simulations in teacher education: the role of learner characteristics as capacities for positive learning experiences and high performance
Authors: Nickl Michael , Huber Sina A. , Sommerhoff Daniel , Codreanu Elias , Ufer Stefan , Seidel Tina 
Published: September 2022

AbstractAssessing students on-the-fly is an important but challenging task for teachers. In initial teacher education, a call has been made to better prepare pre-service teachers for this complex task. Advances in technology allow this training to be done through authentic learning environments, such as video-based simulations. To understand the learning process in such simulations, it is necessary to determine how cognitive and motivational learner characteristics influence situative learning experiences, such as the perception of authenticity, cognitive load, and situational motivation, during the simulation and how they affect aspects of performance. In the present study, N = 150 pre-service teachers from German universities voluntarily participated in a validated online video-based simulation targeting on-the-fly student assessments. We identified three profiles of learner characteristics: one with above average knowledge, one with above average motivational-affective traits, and one with below average knowledge and motivational-affective traits. These profiles do not differ in the perception of the authenticity of the simulation. Furthermore, the results indicate that the profiled learners navigate differently through the simulation. The knowledgeable learners tended to outperform learners of the other two profiles by using more learning time for the assessment process, also resulting in higher judgment accuracy. The study highlights how learner characteristics and processes interact, which helps to better understand individual learning processes in simulations. Thus, the findings may be used as a basis for future simulation research with a focus on adaptive and individual support.
The effect of preprocessing filters on predictive performance in radiomics
Authors: Demircioğlu Aydin 
Published: September 2022

Abstract
Background
Radiomics is a noninvasive method using machine learning to support personalised medicine. Preprocessing filters such as wavelet and Laplacian-of-Gaussian filters are commonly used being thought to increase predictive performance. However, the use of preprocessing filters increases the number of features by up to an order of magnitude and can produce many correlated features. Both substantially increase the dataset complexity, which in turn makes modeling with machine learning techniques more challenging, possibly leading to poorer performance. We investigated the impact of these filters on predictive performance.

Methods
Using seven publicly available radiomic datasets, we measured the impact of adding features preprocessed with eight different preprocessing filters to the unprocessed features on the predictive performance of radiomic models. Modeling was performed using five feature selection methods and five classifiers, while predictive performance was measured using area-under-the-curve at receiver operating characteristics analysis (AUC-ROC) with nested, stratified 10-fold cross-validation.

Results
Significant improvements of up to 0.08 in AUC-ROC were observed when all image preprocessing filters were applied compared to using only the original features (up to p = 0.024). Decreases of -0.04 and -0.10 were observed on some data sets, but these were not statistically significant (p > 0.179). Tuning of the image preprocessing filters did not result in decreases in AUC-ROC but further improved results by up to 0.1; however, these improvements were not statistically significant (p > 0.086) except for one data set (p = 0.023).

Conclusions
Preprocessing filters can have a significant impact on the predictive performance and should be used in radiomic studies.
Non-vitamin K antagonist oral anticoagulants in adults with congenital heart disease
Authors: Ban Ji-Eun 
Published: September 2022

AbstractDespite an improved survival rate, cardiovascular accidents including thromboembolic events are a common cause of death in adults with congenital heart disease (CHD). Therefore, many adult patients with CHD require long-term oral anticoagulants depending on disease complexity, atrial tachyarrhythmia, residual intracardiac shunt, ventricular dysfunction, and the presence of a prosthetic valve. Although prevention of stroke and pulmonary embolism has traditionally been managed with vitamin K antagonists (VKA), recent guidelines suggest the use of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with adult CHD presenting with atrial fibrillation (AF), stroke, or pulmonary embolism. NOACs are an efficient alternative to VKA with reduced bleeding propensity, relatively low dietary and drug interactions, and the potential to eliminate the need for international normalized ratio monitoring in patients with nonvalvular AF. Recently, several multicenter studies reported the indication for thromboprophylaxis and the potential role of NOACs in adult CHD patients. In this review, we aim to assess the efficacy and safety of NOACs in adult CHD patients and to pursue adequate anticoagulation strategies in this special population.
Assessment of left atrial remodeling using speckle tracking echocardiography after percutaneous atrial septal defect closure in adult patients
Authors: Choi Ji-Hoon , Kim Ju Youn , Hwang Jin Kyung , Kim Hye Ree , Chung Tae Wan , Kim Juwon , Park Seung Woo , Kang I-Seok , Song Jinyoung , Park Seung-Jung , Park Kyoung-Min , On Young Keun , Kim June Soo , Huh June 
Published: September 2022

Abstract
Background
Atrial fibrillation (AF) is a well-known, long-term complication of atrial septal defect (ASD) in adults, even after device closure. Left atrial (LA) strain rate applied to the analysis of chamber function has been demonstrated to be an important predictor of LA reverse remodeling. This study aimed to determine the changes in chamber function after device closure of ASD.

Methods
This prospective study enrolled adults with secundum ASD undergoing transcatheter device closure from December 2016 to August 2017. We analyzed the clinical characteristics and LA strain rate before and six months after ASD closure.

Results
A total of 11 patients were enrolled. The mean age was 42.6 ± 9.9 years, and six (54.5%) were females. There was no significant change of conventional echocardiographic parameters after ASD closure. The mean global LA reservoir strain rate before ASD closure was 1.17 ± 0.34 and 0.85 ± 0.30 after ASD closure (p = 0.030). The median global LA conduit strain rate was 0.68 (0.42–1.16) and 0.41 (0.16–0.79) before and after ASD closure (p = 0.213), respectively. The mean global LA contractile strain rate at the six-month follow-up showed significant improvement compared with pre-procedural strain rate (0.33 ± 0.65 vs. − 0.43 ± 0.38, p = 0.006).

Conclusions
LA functional changes occurred during the six-month follow-up, while LA and right atrial (RA) geometric changes were not significant. LA reverse remodeling was proved by restoration of LA late diastolic contractile function.
Probing nutritional and functional properties of salted noodles supplemented with ripen Banana peel powder
Authors: Pasha Imran , Basit Abdul , Ahsin Muhammad , Ahmad Farah 
Published: September 2022

AbstractBanana peel is appreciated for higher dietary fiber, phenolics, flavonoid contents, and minerals (particularly iron, calcium, and potassium), despite being a waste product. After drying, it can be processed into powder/flour to be combined with wheat flour (WF) for development of value-added products. In this study, we substituted WF with banana peel powder (BPP) at supplementation rates of 5, 10, and 15%, and evaluated their suitability to develop salted noodles. The results showed that the composite flour with 15% BPP had significantly higher protein, ash, and crude fiber content as compared to control. Higher antioxidant capacity was observed in composite flour noodles: total phenolics content (TPC), total flavonoid content (TFC), ferric reducing power (FRAP) and DPPH reducing power were increased up to 278, 260, 143 and 13 percent respectively in the noodles containing 15% BPP as compared to control (100% WF). On the other hand, values for viscosity decreased up to 22% with addition of BPP in WF. Furthermore, water absorption capacity and cooking losses were increased up to 15 and 13 percent respectively with 15% BPP incorporation in WF. Results for sensory evaluation demonstrated that noodles with 10% BPP scored highest for sensory profile.
Graphical abstract
Depressive symptoms and its correlates among medical students in Upper Egypt
Authors: Mohammed Heba M. , Soliman Sara M. , Abdelrahman Ahmed A. , Ibrahim Ahmed K. 
Published: September 2022

Abstract
Background
Medical students are at high risk of developing depressive symptoms rather than their age-matched group as medical education is stressful and medical students have psychological and academic stressors. The study aimed to estimate the prevalence of depressive symptoms and the most important correlates associated with it among Assiut University Medical Students in the academic year 2019–2020. It is a cross sectional study conducted among 766 medical students at Assiut University in the academic year 2019–2020, screening for depressive symptoms was by patient health questionnaire-9 (PHQ-9).

Results
The mean age of students was 21.27 ± 1.9, 55.5% of them have depressive symptoms. Female students had statistically significantly higher percent of depressive symptoms compared with males (58.9% vs 51.2%), there was statistically significant lower mean socio-economic score among students having depressive symptoms compared to students with no depressive symptoms (5.73 ± 2.46 and 6.22 ± 2.5 respectively). Students having depressive symptoms had higher mean scores of stresses. The multivariable regression revealed that younger age of the students (OR = 0.797; p < 0.001), having a chronic disease (OR = 3.174; P = 0.024), lower life satisfaction score (OR = 0.908; p < 0.001), students with higher medical stress score (OR = 3.596, P < 0.001), and high sense of control score (OR = 2.323; p < 0.001) were the significant correlates of depressive symptoms among medical students.

Conclusions
Female gender, low socio-economic status, having chronic disease, presence of family history of either mental illness or depressive symptoms, low satisfaction with life, higher total medical stressors, and low sense of control were the most important correlates of depressive symptoms among medical students.
Value of apparent diffusion coefficient factor in correlation with the molecular subtypes, tumor grade, and expression of Ki-67 in breast cancer
Authors: Hegazy Rania , Azzam Heba 
Published: September 2022

Abstract
Background
Breast cancer is known to be the most common cancer in women; in the last decade, contrast-enhanced magnetic resonance imaging has become an important tool in the diagnosis of cancer breast. Numerous studies have analyzed associations between imaging and histopathological features as well as the proliferation potential of breast cancer. The purpose of this study was to evaluate the relationship between the apparent diffusion coefficient (ADC) and expression of Ki-67 as well as tumor molecular subtype in breast cancer.

Results
No significant difference between the mean ADC value of tumors of grade I, II, and III was found. However, there was a significant difference between the mean ADC value of tumors of molecular type A and molecular type B (P = 0.000), HER2 overexpression (P = 0.018), and TN (P = 0.000), respectively. However, there was no significant difference between molecular type B, HER2 overexpression and TN. Also, no significant difference was found between the Ki-67 value of tumors of grade I, II, and III. Yet there was a significant difference between the mean ADC value of tumors of molecular type A and molecular type B (P = 0.000), HER2 overexpression (P = 0.014), and TN (P = 0.000), respectively. However, there was no significant difference between molecular type B, HER2 overexpression, and TN.

Conclusions
There is a significant inverse correlation between ADC values and Ki-67 expression. DWI and Ki-67 could be a good discriminator between tumors of molecular subtype A from other subtypes, yet it did not show a correlation with the tumor grade.
β-Cell Cre Expression and Reduced Ins1 Gene Dosage Protect Mice From Type 1 Diabetes
Authors: Skovsø Søs , Overby Peter , Memar-Zadeh Jasmine , Lee Jason T C , Yang Jenny C C , Shanina Iryna , Sidarala Vaibhav , Levi-D’Ancona Elena , Zhu Jie , Soleimanpour Scott A , Horwitz Marc S , Johnson James D 
Published: September 2022

Abstract
A central goal of physiological research is the understanding of cell-specific roles of disease-associated genes. Cre-mediated recombineering is the tool of choice for cell type–specific analysis of gene function in preclinical models. In the type 1 diabetes (T1D) research field, multiple lines of nonobese diabetic (NOD) mice have been engineered to express Cre recombinase in pancreatic β cells using insulin promoter fragments, but tissue promiscuity remains a concern. Constitutive Ins1tm1.1(cre)Thor (Ins1Cre) mice on the C57/bl6-J background have high β-cell specificity with no reported off-target effects. We explored whether NOD:Ins1Cre mice could be used to investigate β-cell gene deletion in T1D disease modeling. We studied wild-type (Ins1WT/WT), Ins1 heterozygous (Ins1Cre/WT or Ins1Neo/WT), and Ins1 null (Ins1Cre/Neo) littermates on a NOD background. Female Ins1Neo/WT mice exhibited significant protection from diabetes, with further near-complete protection in Ins1Cre/WT mice. The effects of combined neomycin and Cre knockin in Ins1Neo/Cre mice were not additive to the Cre knockin alone. In Ins1Neo/Cre mice, protection from diabetes was associated with reduced insulitis at age 12 weeks. Collectively, these data confirm previous reports that loss of Ins1 alleles protects NOD mice from diabetes development and demonstrates, for the first time, that Cre itself may have additional protective effects. This has important implications for the experimental design and interpretation of preclinical T1D studies using β-cell-selective Cre in NOD mice.
Castration of Male Mice Induces Metabolic Remodeling of the Heart
Authors: Svedlund Eriksson Elin , Johansson Inger , Mårtensson Anna K F , Lantero Rodriguez Marta , Schilperoort Maaike , Kroon Jan , Kooijman Sander , Omerovic Elmir , Andersson Linda , Levin Malin C , Rensen Patrick C N , Tivesten Åsa 
Published: September 2022

Abstract
Androgen deprivation therapy of prostate cancer, which suppresses serum testosterone to castrate levels, is associated with increased risk of heart failure. Here we tested the hypothesis that castration alters cardiac energy substrate uptake, which is tightly coupled to the regulation of cardiac structure and function. Short-term (3-4 weeks) surgical castration of male mice reduced the relative heart weight. While castration did not affect cardiac function in unstressed conditions, we observed reductions in heart rate, stroke volume, cardiac output, and cardiac index during pharmacological stress with dobutamine in castrated vs sham-operated mice. Experiments using radiolabeled lipoproteins and glucose showed that castration shifted energy substrate uptake in the heart from lipids toward glucose, while testosterone replacement had the opposite effect. There was increased expression of fetal genes in the heart of castrated mice, including a strong increase in messenger RNA and protein levels of β-myosin heavy chain (MHC), the fetal isoform of MHC. In conclusion, castration of male mice induces metabolic remodeling and expression of the fetal gene program in the heart, in association with a reduced cardiac performance during pharmacological stress. These findings may be relevant for the selection of treatment strategies for heart failure in the setting of testosterone deficiency.
Autophagy of the somatic stalk cells nurses the propagating spores of Dictyostelid social amoebas
Authors: Du Qingyou , Schaap Pauline 
Published: September 2022

Background: Autophagy (self-feeding) assists survival of starving cells by partial self-digestion, while dormancy as cysts, spores or seeds enables long-term survival. Starving Dictyostelium amoebas construct multicellular fruiting bodies with spores and stalk cells, with many Dictyostelia still able to encyst individually like their single-celled ancestors. While autophagy mostly occurs in the somatic stalk cells, autophagy gene knock-outs in Dictyostelium discoideum (D. discoideum) formed no spores and lacked cAMP induction of prespore gene expression. Methods: To investigate whether autophagy also prevents encystation, we knocked-out autophagy genes atg5 and atg7 in the dictyostelid Polysphondylium pallidum, which forms both spores and cysts. We measured spore and cyst differentiation and viability in the knock-out as well as stalk and spore gene expression and its regulation by cAMP. We tested a hypothesis that spores require materials derived from autophagy in stalk cells. Sporulation requires secreted cAMP acting on receptors and intracellular cAMP acting on PKA. We compared the morphology and viability of spores developed in fruiting bodies with spores induced from single cells by stimulation with cAMP and 8Br-cAMP, a membrane-permeant PKA agonist. Results: Loss of autophagy in P. pallidum reduced but did not prevent encystation. However, spore, but not stalk differentiation, and cAMP-induced prespore gene expression were lost. Spores induced in vitro by cAMP and 8Br-cAMP were smaller and rounder than spores formed multicellularly and while they were not lysed by detergent they did not germinate, unlike multicellular spores. Conclusions: The stringent requirement of sporulation on both multicellularity and autophagy, which occurs mostly in stalk cells, suggests that stalk cells nurse the spores through autophagy. This highlights autophagy as a major cause for somatic cell evolution in early multicellularity.
Measles: A disease that’s making a comeback
Authors: Bojarska Małgorzata , Domańska Natalia , Brzyska Anna , Bogucka Julia , Wilczek Natalia , Piecewicz-Szczęsna Halina 
Published: September 2022

Introduction: Measles is a highly contagious viral disease that occurs around the world, featured by fever and the characteristic maculopapular rash, which can also be associated with cough, conjunctivitis or coryza. In recent years, there has been an alarming increase in the amount of measles cases in many countries around the world. The aim of this study is to review the literature and systematize knowledge about measles.Brief description of the state of knowledge: The disease is caused by the measles virus, which is highly infectious, and its only reservoir is humans. The infection occurs via droplets, and the disease is a three-phase course. Unfortunately, measles is behind multiple complications, which may lead to death. In view of no specific antiviral therapies available for the treatment of measles, controlling the spread of the disease depends on prophylaxis, that is the use of widely available and effective vaccination against measles. Despite the presence of vaccines, there is still a substantial risk of further endemic outbreaks.
Conclusions: Nowadays, the elimination of measles is a major challenge due to increasing population density, ongoing wars, pandemics and other social and political factors. Hence, it remains paramount to make every effort to increase the quantity of people vaccinated against measles and to control its spread globally.
David Hume i Adam Smith o sympatii
Authors: Grzeliński Adam Jerzy , Markwart Anna 
Published: September 2022

Artykuł zawiera porównanie dwóch koncepcji sympatii, autorstwa Davida Hume’a i Adama Smitha. Chociaż w obu systemach filozoficznych pojęcie topełni centralną rolę, jej znaczenie jest nieco inne. Drobiazgowe analizy teoriopoznawcze Hume’a pozwalają na wyodrębnienie w jego filozofii trzech płaszczyzn opisu: zdroworozsądkowy, mechanicystyczny i fenomenalistyczny, przy czym sympatia pełni na każdej z nich nieco odmienną rolę. Smith dostrzegł centralne znaczenie tego pojęcia w Hume’owskiej koncepcji umysłu i uczuć, a także zaadoptował je w swej teorii uczuć moralnych, ale brak u niego subtelnych analiz „mechaniki” ludzkiego myślenia. Brak ten jednak można traktować zarówno jako zaniedbanie, jednak z drugiej strony – paradoksalnie – pozwala on dostrzec doktrynerski charakter koncepcji Hume’a wynikający z przyjęcia fizykalistycznego modelu eksplikacji ludzkiej afektywności.
Meaningful values of the EQ-5D-3L in patients undergoing primary knee arthroplasty
Authors: Yapp Liam Z. , Scott Chloe E. H. , Howie Colin R. , MacDonald Deborah J. , Simpson A. Hamish R. W. , Clement Nick D. 
Published: September 2022

Aims The aim of this study was to report the meaningful values of the EuroQol five-dimension three-level questionnaire (EQ-5D-3L) and EuroQol visual analogue scale (EQ-VAS) in patients undergoing primary knee arthroplasty (KA). Methods This is a retrospective study of patients undergoing primary KA for osteoarthritis in a university teaching hospital (Royal Infirmary of Edinburgh) (1 January 2013 to 31 December 2019). Pre- and postoperative (one-year) data were prospectively collected for 3,181 patients (median age 69.9 years (interquartile range (IQR) 64.2 to 76.1); females, n = 1,745 (54.9%); median BMI 30.1 kg/m2 (IQR 26.6 to 34.2)). The reliability of the EQ-5D-3L was measured using Cronbach’s alpha. Responsiveness was determined by calculating the anchor-based minimal clinically important difference (MCID), the minimal important change (MIC) (cohort and individual), the patient-acceptable symptom state (PASS) predictive of satisfaction, and the minimal detectable change at 90% confidence intervals (MDC-90). Results The EQ-5D-3L demonstrated good internal consistency with an overall Cronbach alpha of 0.75 (preoperative) and 0.88 (postoperative), respectively. The MCID for the Index score was 0.085 (95% confidence interval (CI) 0.042 to 0.127) and EQ-VAS was 6.41 (95% CI 3.497 to 9.323). The MICCOHORT was 0.289 for the EQ-5D and 5.27 for the EQ-VAS. However, the MICINDIVIDUAL for both the EQ-5D-3L Index (0.105) and EQ-VAS (-1) demonstrated poor-to-acceptable reliability. The MDC-90 was 0.023 for the EQ-5D-3L Index and 1.0 for the EQ-VAS. The PASS for the postoperative EQ-5D-3L Index and EQ-VAS scores predictive of patient satisfaction were 0.708 and 77.0, respectively. Conclusion The meaningful values of the EQ-5D-3L Index and EQ-VAS scores can be used to measure clinically relevant changes in health-related quality of life in patients undergoing primary KA. Cite this article: Bone Joint Res 2022;11(9):619–628.
September 2022 Pulmonary Case of the Month: A Sanguinary Case
Authors:   Department of Pulmonary Medicine, Mayo Clinic Arizona, Scottsdale, AZ USA, Abdalla Abdelmohaymin , Wesselius Lewis 
Published: September 2022

No abstract available. Manuscript truncated after 150 words. History of Present Illness A 55 years-old woman presented to pulmonary clinic with shortness of breath and chest pain for 4-6 weeks. No specific timing for her symptoms or triggers. The symptoms occurring occasionally at random times. Her dyspnea was not limiting her daily activities, though she has been asking her partners to help with chores more than before. Her chest pain was sharp localized to left posterior chest wall that seldom get worse with taking a deep breath. At worse it’s mild. She also experienced dry cough that is occasional and not bothersome. Past Medical History (PMH), Social History (SH), Family History (FH) PMH •	Paraplegia secondary to gunshot wound to T11-12 in 2003; wheelchair-bound •	COVID 2021, incidentally diagnosed with no pulmonary symptoms •	Carpal tunnel syndrome, bilateral •	Acne •	GERD •	Splenectomy 2003 after uncontrolled bleeding from splenic laceration following gunshot wound •	Tubal ligation 2005 SH •	Former tobacco use, 15 pack-years, quit …