bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergising decision making and interventions across human health and environment: concepts for designing a model for infectious diseases
Authors: Stanhope Jessica , Mayfield Helen J. , Guillaume Joseph H. A. , Sahin Oz , Weinstein Philip , Lau Colleen 
Published: May 2022

The impact of environmental factors on human health outcomes is well established. It is therefore not surprising that interventions aimed at improving human health are often environmental-based, such as restoring riparian vegetation for flood mitigation, with a view to reducing associated infectious disease transmission. Yet the risks and benefits of these interventions on the environment itself are rarely measured, or weighed up against potential health gains. One of the challenges with such an evaluation is the requirement for cross-sectoral support from decision makers in both the health and environmental sectors. To facilitate this support, cross-sectoral models are required that simultaneously estimate the impact of proposed environmental interventions on both sectors. Despite their obvious value, a systematic search of the peer-reviewed literature did not identify any model that concurrently models the impact of environmental intervention on both environmental and human infectious disease related outcomes. In this paper, we conceptually explore potential approaches for designing such a model, using leptospirosis as a case study to highlight the various data sources, spatial scales, temporal scales and required system behaviour that would need to be integrated for a cross-sectoral model of this complexity. By comparing these system requirements against the strengths and limitations of individual modelling techniques, we demonstrate the potential benefits of a hybrid-ensemble approach that uses component models from different frameworks. By combining the strengths of the different techniques to tackle this wicked problem, such a modelling approach supports the prioritisation of environmental interventions that optimise the overall benefit by considering impacts on both human health and the environment.
Understanding smallholder farmer decision making in forest land restoration using agent-based modeling
Authors: Ahimbisibwe Vianny , Groeneveld Jürgen , Lippe Melvin , Tumwebaze Susan Balaba , Auch Eckhard , Berger Uta 
Published: May 2022

Success of forest restoration at farm level depends on the farmer´s decision-making and the constraints to farmers’ actions. There is a gap between the intentions and the actual behavior towards restoration in Sub-Saharan Africa and the Global South. To understand this discrepancy, our study uses empirical household survey data to design and parameterize an agent-based model. WEEM (Woodlot Establishment and Expansion Model) has been designed based on household socio-demographics and projects the temporal dynamics of woodlot numbers in Uganda. The study contributes to a mechanistic understanding of what determines the current gap between farmer’s intention and actual behavior. Results reveal that an increase in knowledge of the current forest policies laws and regulations (PLRs) from 18% to 50% and to 100% reduces the average number of woodlots by 18% and 79% respectively. Lack of labor reduces the number of woodlots by 80%. Increased labor requirement from 4 to 8 and to 12 man-days, reduces the number of woodlots by 26% and 61% respectively. WEEM indicates that absence of household labor and de facto misconception of PLRs “perceived tenure insecurity” constrains the actual behavior of farmers. We recommend forest PLRs to provide full rights of use and ownership of trees established on private farmland. Tree fund in the case of Uganda should be operationalized to address the transaction costs and to achieve the long-term targets of forest land restoration.
A retrospective study of the prevalence and management of complications of proliferative diabetic retinopathy and its visual outcome in patients in a tertiary care hospital
Authors: Bokhari Syed Saifullah , Sujatha M A Rani , KC Ranjitha , Sinha Durgesh Kumar , Karanvi Shweta B , B J Sannidhi 
Published: May 2022

To provide the prevalence of complications of proliferative diabetic retinopathy (PDR) in patients visiting the retina clinic in Dr. B. R. Ambedkar Medical College and Hospital and to evaluate their visual acuity (VA) status. A retrospective study in which the chart review was done of the patients diagnosed with PDR, attending the retina clinic in Dr. B.R. Ambedkar Medical College and Hospital. Patients with a diagnosis of type 1 or 2 diabetes with a clinical diagnosis of active PDR in any or both eyes, who had long term follow-up for up to at least 5 years were included. Evaluating the prevalence of the complications of PDR, presenting VA of people with PDR, short-term outcomes at 6 months and 5 years are the main outcomes of the study. The most common complication of PDR was diabetic macular edema (DME). Eyes receiving treatment early in the disease course (i.e. baseline VA 6/18 or better) had significantly better VA outcomes at 5 years versus eyes treated at a later stage (i.e. baseline VA &#60;6/18 - ≥3/60). The treatment of patients with VA &#60;3/60 can also lead to significant improvement in visual outcome. Our results suggest that early diagnosis and treatment of patients with PDR is of utmost importance in preventing severe vision loss due to advanced diabetic eye disease. People with diabetes in India need to be made aware of annual screening and treatment of their eyes to avoid vision impairment and blindness.
A clinical study on prevalence and management of eyelid tumours – A prospective observational study
Authors: Karthik Senthil Kumar Niranjan , R Malarvizhi , A Anuradha , KST Latha 
Published: May 2022

To study the incidence of eyelid tumours pertaining to age, sex, lid, globe or orbital involvement and analyse the various aspects of treatment modalities and their functional and cosmetic outcome. A prospective study of 40 cases of eyelid tumours over a period of 1 year, both benign and malignant eyelid lesions were included and those with inflammatory lesions were excluded. Patients were evaluated and treated with appropriate modalities and the outcome was analysed. Malignant tumours were common in the age group between 60-85 years and benign tumours were common in the age group of 30-45 years. Benign tumours were more common among males and malignant tumours more common among females. Out of the 40 cases, 28 (70 %) eyelid lesions were benign and 12 (30%) cases were malignant. Benign tumours were found more commonly in the upper lid and malignant tumours in lower lid. Squamous papilloma was found to be the most common benign tumour, followed by pyogenic granuloma. Meibomian carcinomais the most common malignant tumour. Most common presentation of malignant eyelid tumour was ulcerative growth pattern. Meibomian carcinoma presented in the form of nodule and ulcerative growth pattern. The treatment for most of the benign tumour was simple excision and malignant tumour was wide local excision with 4-5 mm margin clearance. Glabellar rotation flap was performed in one case of meibomian carcinoma involving the medial aspect of lower lid after excision. Hughes tarso-conjunctival flap was performed in two cases of squamous cell carcinoma and basal cell carcinoma, after tumour excision as the defect involved more than 75% of the lower lid without involvement of canthus. Two cases one each of sebaceous carcinoma and squamous cell carcinoma involving the lateral aspect of lower lid was reconstructed after excision, with Tenzel flap. In one case of sebaceous gland carcinoma with diffuse involvement of the upper lid the was excised and reconstructed with Cutler-Beard technique.Histopathologic examination of all excised lesion must be done as an innocuous looking lesion might be malignant. Early clinical suspicion of malignancy and confirmation by incisional biopsy will aid in planning wide excision and appropriate method of lid reconstruction depending on the amount of lid loss. After wide excision of malignant tumour appropriate lid reconstruction technique is done as a primary procedure in all our patients and we could obtain good outcomes with no recurrences. Advanced tumours with orbital involvement and recurrent tumour need adjuvant chemotherapy or radiotherapy.
The Feminist Movement: Major Contributions, Perspectives, Communication Landmarks
Authors: Durac Livia 
Published: May 2022

The sensitization of the human being regarding the correction of some accumulated injustices ontologically towards femininity is a desideratum that urges reflection, the feminist movement being, for more than a century, the way to reach this desideratum.
The issue of discrimination against women allows for the most varied approaches, due to the diversity of plans and forms under which this phenomenon makes its presence felt, day after day, in any corner of the world. Perceptual abnormality, of patriarchal origin, which perpetually fuels the subordination of women to the opposite sex, blocking in patterns of thinking and behaviour with oppressive accents intensifies and justifies the continuation of feminist activism under its various forms of manifestation.
Feminism does not have the connotation of a simple action to claim rights but is a very complex combination of actions and attitudes, through which the socio-political assertion of women transcends the classical doctrines of rights and freedoms, which remain what has been proven: to be simple theorizations.
Starting from some philosophical considerations, the article brings to the fore the main contributions that have substantiated and structured, ennobling through their value the feminist movement, the succession of reference stages, particularities of feminism, depending on the sphere of influence, ending with a perspective on the confluence of feminism and communication.
Alternative Prognosis of Recovery Assessment for the Hemiplegic Limb (APRAHL): a biomarker-free algorithm that predicts recovery potential for the hemiplegic upper-limb.
Authors: Athanasiadis Dimitrios , Dionyssiotis Yannis , Athanasiadis Dimitrios , Stefas Eleftherios 
Published: May 2022

Abstract
Objective
Stroke is a significant cause of disability, rendering patients with inability to perform activities of daily living due to lack of functional recovery. Precise prognosis in the early stage after stroke could enable realistic goal-setting and efficient resources allocation. Prediction algorithms have been tested and validate in the past, but they were using neurological biomarkers, thus they were time-consuming, difficult to apply, expensive and dangerous. The aim of this study was to create a new prediction algorithm that would not utilize any biomarkers.
Methods
127 stroke patients prospectively enrolled at day 3 after their stroke (mean age: 71, males: 84, females: 43). First, a sum of shoulder abduction and finger extension (SAFE) MRC score was graded at day 3. Secondly, a binarized response was marked by the MaSoNT’s basic application on the upper-limb. Third, the NIHSS score was assessed. All data from the patients were included in a Classification and Regression Tree analysis to predict upper limb function 3 months poststroke according to the Action Research Arm Test score at week 12.
Results
The CART analysis produced that combines three different scores in order to predict upper-limb recovery: the SAFE score, MaSoNT’s application response and the NIHSS. The overall correct prediction of the new algorithm is 69% which is lower than previous algorithms, though not significantly.
Conclusion
This study offers basic data to support the validity of the APRAHL algorithm. The new algorithm is faster and easier, but less accurate than the previous similarly-designed ones. Future studies are necessary to generalize and validate APRAHL.
Incidence and associated factors of cetuximab-induced hypersensitivity infusion reactions in 1392 cancer patients treated in four French areas: A possible association with Lyme disease?
Authors: Dupont Marine , Carlier Claire , Gower-Rousseau Corine , Barbier-Lider Pauline , Botsen Damien , Brasseur Mathilde , Burgevin Alice , Chourbagi Christophe , D’Almeida Rosario , Hautefeuille Vincent , Hentzien Maxime , Lambert Aurélien , Lamuraglia Michele , Lavau-Denes Sandrine , Lopez Anthony , Parent Damien , Slimano Florain , Brugel Mathias , Bouché Olivier 
Published: May 2022

Abstract
Background Previous studies have observed an increased incidence of Cetuximab-induced hypersensitivity infusion reactions (CI-IRs) in the southeastern states of the USA. Tick’s bites were suspected of generating cross-reactions between cetuximab and alpha-gal. This study aims was to describe the incidence and associated risk factors of CI-IRs, in the French areas chosen according to their Lyme disease incidence.Patients and methods A retrospective chart review was conducted on patients that received cetuximab infusion from January 2010 to June 2019 in 4 French areas with different Lyme disease incidence rates. Results Of 1392 patients, 117 (8.4%) experienced a CI-IR, including 68 severe (grade 3 or 4) reactions (4.9%). This CI-IR incidence was significantly higher in the Lyme disease high-risk area than in the other areas (13.2% versus 7.1%, 8.1% and 6.4%; P=0.016). Sex (P=0.53), premedication (P=0.91), primary cancer location (P=0.46) and chemotherapy regimen type (P=0.78) had no impact on CI-IR incidence in the overall population. In the head and neck squamous cell carcinoma (HNSCC) patient subgroup, CI-IRs were significantly more frequent in the high-risk area (16.4% versus 6.7%, 7.1% and 7.0%; P=0.0015). ConclusionThis study suggests that patients treated in the French area with the highest incidence of Lyme disease are at a higher risk of CI-IRs.
Enteric pathogens and histology of collared peccaries (Mammalia, Tayassuidae) according to levels of dietary fiber and interindividual behavioral differences
Authors: Cairo Pedro Leon Gomes , Gross Eduardo , Nogueira Selene Siqueira da Cunha , Lopes Amanda Teixeira Sampaio , Maciel Bianca Mendes , Vandenheede Marc , Bindelle Jérome , Nogueira-Filho Sérgio Luiz Gama 
Published: May 2022

Abstract
We aimed to measure differences in hindgut pH, intestinal histological parameters and occurrence of enteric pathogens in the collared peccary (Dicotyles tajacu), according to dietary fiber levels and interindividual behavioral differences. Samples of ileum and cecum (tissue and content) were collected from 24 adult males classified according to their behavioral traits, and which received either low (n = 12) or high-fiber (n = 12) diets. Salmonella spp. was discovered in the cecum content of the most distressed individual. Non-pathogenic E. coli was present in 21 of the 24 collared peccaries. The pH in cecum samples was higher when animals were fed with high-fiber diet. The depth of the crypt (CD) was correlated with the peccaries’ behavioral traits: the more relaxed, the higher the CD. Associations linking individual behavioral qualities, dietary fiber, pH, histology of the hindgut and the presence of enteric pathogens in farmed peccaries are multifaceted. The existence of Salmonella in the hindgut of the distressed individual and the positive impact of behavioral calmness traits on some intestinal histological parameters suggests the possible benefit of selecting calm individuals, from the point of view of both animal and human health and welfare.
Detecting Distributed Denial of Service (DDoS) in SD-IoT Environment with Enhanced Firefly Algorithm and Convolution Neural Network
Authors: N. Sivanesan 
Published: May 2022

Abstract
In Recent years, Network security becomes essential due to increase in usage of Smart phones and Internet of Things (IoT) devices. An IoT device plays a vital role in day to day life of human being. Such IoT devices are less secured and mostly used under abandoned environment. Recently these devices are widely affected by Distributed Denial of Service (DDoS) attack. DDos is one of the risky threats that destroy the critical network services. The extreme flow of packets in a network results in attack. Single source attack raises the Denial of Service (DoS); on the other hand attack rises from multiple servers referred to as DDoS. Researchers have developed software-defined networks (SDN) to effectively handle IoT equipment. To overcome above issue, we use an updated firefly algorithm to optimize the convolutional neural network (CNN) for detection of DDoS attacks in software-defined Internet of Things (SD-IoT) environment. Experimental result shows that our proposed model achieves 98% accuracy over detection of DDoS attack.
The effect of pre-treatment and anaerobic digestion for pathogens reduction in agricultural utilization of sewage sludge
Authors: Machnicka Alicja , Grübel Klaudiusz 
Published: May 2022

Abstract
The aim of the research work was to explain the possibilities of application of waste activated sludge (WAS) pretreatment processes prior to anaerobic digestion (mesophilic fermentation). Hydrodynamic disintegration and freezing/thawing disintegration methods were used. Based on the microbiological and parasitological analyses, a significant decrease in pathogenic bacteria, coliphages and parasite eggs was observed. The number of bacteria analysed (Salmonella sp., Escherichia coli, Clostridium perfringens) and coliphages were reduced from 19.3–42.3% after hydrodynamic cavitation. A similar effect was achieved for destruction by freezing/thawing with dry ice – between 7.8–14.9%. The effectiveness of parasite eggs reduction (Ascaris sp., Trichuris sp., Toxocara sp.) for these disintegration methods ranged from 10.7–29.3%. The highest results were observed for the hybrid disintegration method (hydrodynamic cavitation + dry ice disintegration) caused by a synergistic effect. Salmonella sp. in 1 gd.w. decrease about 69.7%, E. coli by 70.0%, Clostridium perfringens by 38.4%, coliphages by 48.2%. Disruption of WAS by a hybrid method led to a reduction in the number of helminth eggs Ascaris sp. (63.8%), Trichuris sp. (64.3%) and Toxocara sp. (66.4%). After anaerobic digestion under mesophilic conditions, an additional reduction of analysed bacterial pathogens and helminth eggs were observed. The introduction of hybrid disintegrated WAS to the fermentation chamber resulted in higher efficiency in decrease (from 1–23%) in comparison to the control sample (70%WAS + 30%DS (inoculum – digested sludge)).
Mixed culture of plants improved nutrients removal in constructed wetlands: response of microbes and root exudates
Authors: Wang Zhufang , Zhang Yinjing , Li Xiao , Li Jinkun , Zhao Zhimiao , Hou Xin 
Published: May 2022

Abstract
Root exudates are determined by plant species configuration and affect microbial community, which in turn affect purification efficiency of constructed wetlands (CWs). However, it is not well understood how the plant configuration affects CWs purification efficiency through specific root exudates. Herein, four mixed culture CWs were constructed, CW-G3 with Iris pseudacorus, Iris sibirica, Juncus effusus, and Hydrocotyle vulgaris showed the optimal diversity nutrients removal efficiency (TN: 94.2%, TP: 82.9%, COD: 74.7%). Highly increased antioxidant enzymes (peroxidase and catalase) reduced photosynthesis-negative enzyme (malondialdehyde) activity of plants in CW-G3, which ensured oxygen (O2) and organic carbon (OC) production and successfully released to rhizosphere by well-developed root aeration tissues. Further, plant configurations resulted in diversity microbial communities, CW-G3 enriched higher abundance of genus Saccharimonadales and Flavobacterium, which benefited nitrogen removal. More importantly, as OC, higher contents of maltose in CW-G3 (6.6 ~ 11.1 folds of that in other three CWs), as well as lauramide, choline, triethylamine and urocanic acid contributed to microbial denitrifying. Differently, higher contents of unsaturated fatty acids linoleic acid and oleic acid in other three CWs inhibited their microbial nitrifying, rather than utilized by bacteria as OC. Co-occurrent network results also proved the interactions between root exudates and functional bacteria. Thereby, plant configuration in CW-G3 provided higher O2 and OC contents for bacteria, and reduced nitrifying inhibitors, which contributed to higher purifying efficiency. The study promoted the understanding about root exudates’ effects on bacteria through plant configurations, and improved the purification efficiency of CWs.
Magnetic methods for phase control in titanium-base alloy synthesized by ball milling
Authors: ABADA Abderahim , YOUNES Abderrahmane 
Published: May 2022

Abstract
The nanocrystalline TiAlV alloys have been synthesized from pure titanium, aluminum and vanadium powders by mechanical alloying technique within a high energy planetary ball-mill. Magnetic behavior, Morphology and micro-structural properties were examined by a Vibrating sample magnetometer (VSM), Scanning Electron Microscope (SEM), and X-ray diffraction (XRD), respectively. Crystallite size reduced from 48.73nm to 9.38 nm and lattice strain increased from 0.15% to about 0.81% for 60 hours of grinding. X-ray diffraction testing confirms the apparition of new phases during grinding time. The Magnetic non-destructive testing showed that the nanocrystalline TiAlV contain a magnetic particle which is different from one period to another period, the change of magnetic properties is due by the reduction in crystallite size of magnetic particle which is due to the collision between the balls and the magnetic particles of the powder. The NDT by magnetic measurement confirms that we can control the state of the nanocrystalline alloy using the vibrating magnetometer samples.
Rubber dam isolation increases the costs and does not impact on composite resin restorations’ survival in primary teeth. 2-year results from a non-inferiority clinical trial
Authors: Olegário Isabel C. , Moro Bruna L. P. , Tedesco Tamara K. , Freitas Raiza D. , Pássaro Ana Laura , Garbim Jonathan Rafael , Oliveira Rodolfo , Mendes Fausto M. , Raggio Daniela , Group Cardec Collaborative 
Published: May 2022

Abstract
Background
This non-inferiority randomised trial aimed to evaluate the survival rate, costs and discomfort/behaviour of two operative field isolation methods.
Methods
A total of 93 4–8 years old children (174 molars) with at least one dentine caries lesion were randomly allocated to groups: rubber dam isolation (RDI) and cotton roll isolation (CRI), restored with bulk fill composite resin. Two blinded examiners assessed the restorations up to 24 months. Wong-baker faces, and Frankl’s behaviour rating scales were used for accessing child’s discomfort and behaviour, respectively. For the statistical analysis, the primary outcome (restoration survival) used two-sample non-inferiority test for survival data using Cox Regression, Bootstrap Linear regression analysis for cost analysis and logistic regression for discomfort and behaviour.
Results
157 restorations were evaluated (drop-out = 9.7%). Survival was RDI = 60.4% and CRI = 54.3. The non-inferiority hypothesis was accepted by the Cox Regression analysis (HR = 1.33; 90% CI 0.88–1.99; p = 0.036). RDI was 53% more expensive when compared to the CRI group. No differences were found between the groups in terms of discomfort and behaviour.
Conclusion
Cotton roll isolation proved to be non-inferior when compared to rubber dam for composite restorations longevity in primary molars. Furthermore, the latest presented the disadvantage of higher cost and longer procedure time.
Clinical Significance:
Rubber dam isolation has no impact on the survival of composite restoration in primary molars.
Clinical trial registration:
registered NCT03733522 on 07/11/2018. The present trial was nested within another clinical trial, the CARies DEtection in Children (CARDEC-03 - NCT03520309).