bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of social skills of high school students on virtual platforms, 2021
Authors: Reynosa Navarro Enaidy , Montero Juana María Cruz , Meléndez Lindon Vela , Navarro Enaidy Reynosa 
Published: February 2022

The objective of this study is the development of social skills of high school students in virtual settings. Methodology: Qualitative, phenomenological, hermeneutical study, developed in three stages. In the descriptive stage, planning activities and ethical procedures were socialized; In the structural setting, intervention protocols, contingency plans, methodological memory, approach to participants, and delimitation of roles were foreseen both within and outside the field of study. In the discussion stage, the results were contrasted with recent studies, arriving at definitive conclusions. The technique used was the semi-structured interview, and as an instrument, a guide of questions derived from the subcategories of the study was used. The participants were five students of the sixth cycle of Regular Basic Education (first and the second year of secondary education) with ages of 13 and 14 years, three men and two women volunteers, a teacher (director), and two teachers (without management positions). Experts validated the interview. Results: Reciprocal help in the affective sphere motivates the encounters in virtual settings in the participants. Virtual scenarios mediate effective relationships in a significant way. Conclusions: Reciprocity is a priority element that generates trust and allows participants to understand the needs of their colleagues, virtual spaces serve as emotional support for all their members, and as they all connect with the active cameras, scenarios very similar to those are generated.
Keywords: Social Skills; Emotional Support; Affective Relationships; TIC
Analysis of the state of digital contact habits of primary school students
Authors: Kazaz Nalan , Dilci Tuncay 
Published: February 2022

The aim of this study is to examine the status of digital contact habits of primary school students during the pandemic period. This study is important because it will reveal the difference between primary school students' digital contact habits before and after the COVID-19 period. The study also has the distinction of being the first within the scope of studies conducted at primary school level in the direction of digital life skills and addiction. Survey method was used. The study group consists of 986 parents of primary school students in three different provinces in districts similar to each other in terms of socio-economic and cultural aspects. The collected data were obtained by Digital analyze technique. The data was interpreted in the artificial intelligence-algorithmic system. According to the findings, the addiction rate increased in the study group students during the COVID-19 period, and one out of every four children was digitally dependent.
Keywords: Covid-19; Digitalization; Digital Addiction; digital contact; primary school.
Polacy za granicą i Polonia we współczesnym świecie a wybory prezydenckie w latach 2000–2015
Authors: Alberska Małgorzata , Ściebior-Jońska Patrycja 
Published: February 2022

Due to the complicated history of Poland, many Poles live outside the country. This state was influenced by many processes, such as: economic emigrations, refugees, the effects of deportations carried out by the invaders during World War II and the shift of national borders after it. Polish citizens retain voting rights without any restrictions related to living outside the country and the duration of their stay abroad. These rights are enforced by the country government by creating voting wards in the countries where the Polish diaspora lives.
In order to answer the question about its real influence on shaping the Polish government, the size of the Polish diaspora should be determined and also how much the Poles abroad are involved in domestic affairs. One of the criteria for analyzing their involvement is their participation in the Polish presidential election (the analysis is based on data from the presidential elections taking place from 2000 to 2015).
Aktivitas Sitotoksik dan Induksi Apoptosis dari Ekstrak Etanol Kulit Apel Hijau (Pyrus malus L.) terhadap Sel MCF-7
Authors: Setiawan Syahrul Iqbal , Safitri Erika Indah , Hidayati Devi Nisa , Muna Laili Nailul 
Published: February 2022

Ekstrak kulit apel hijau (Pyrus malus L.) mengandung senyawa Quercetin yang mampu menurunkan ekspresi Bcl-2. Penelitian ini bertujuan untuk mengetahui aktivitas sitotoksik dan induksi apoptosis ekstrak etanol kulit apel hijau (EEKAH) pada model sel kanker payudara MCF-7. Serbuk kulit apel hijau diekstraksi menggunakan pelarut etanol 70% dengan metode ultrasonik. Uji sitotoksik terhadap sel kanker payudara MCF-7 dengan metode MTT Assay pada konsentrasi EEKAH yaitu 31,25; 62,5; 125; 250; 500 dan 1000 µg/mL. Hasil uji sitotoksik dihitung nilai IC50menggunakan regresi linier. Pengamatan induksi apoptosis dengan konsentrasi ½ IC50(442,5 μg/ml) dan IC50 (885 μg/ml) menggunakan flowcytometry. Analisis data dianalisis menggunakan analisis statistik One Way Anova. Hasil penelitian menunjukan bahwa EEKAH memiliki aktivitas sitotoksik dengan nilai IC50 sebesar 885 µg/ml. Persentase rata-rata fase apoptosis total EEKAH pada konsentrasi ½ IC50sebesar 30,2% (p>0,05) dan IC50 sebesar 47,9% (p<0,05) dibandingkan kontrol sel sebesar 12,7%. EEKAH mampu menginduksi apoptosis terhadap sel MCF-7. Kata kunci: MCF-7, Pyrus malus L., Sitotoksisitas, Apoptosis Green apple peel extract (Pyrus malus L.) contains Quercetin compound which decrease Bcl-2 expression. The aims of this study was to determined the cytotoxic activity and apoptosis induction of green apple peel ethanol extract (GASEE) on MCF-7 breast cancer cells. The green apple peel powder was extracted using 70% ethanol solvent by ultrasonic method. Cytotoxic test against MCF-7 breast cancer cells using the MTT Assay method at the GASEE concentration, namely 31.25; 62.5; 125; 250; 500 and 1000 µg/mL. The results of the cytotoxic test calculated the IC50 value using linear regression. Determination of apoptosis induction with a concentration of ½ IC50 (442.5 µg/mL) and IC50 (885 µg/mL) using flowcytometry. Data analysis was analyzed using statistical analysis One Way Anova. The results showed that GASEE has cytotoxic activity with an IC50 value of 885 µg/ml. Average percentage of total apoptosis phase are ½ IC50 concentration of 30.2% (p>0.05) and IC50 of 47.9% (p<0.05) than cell control of 12.6%. GASEE can apoptosis induced against MCF-7 cells.
Uji Aktivitas Antioksidan dan Antitirosinase Fraksi n-Butanol Daun Sungkai (Peronema canescens Jack.) Secara Kualitatif Menggunakan Kromatografi Lapis Tipis
Authors: Fadlilaturrahmah Fadlilaturrahmah , Putra Aditya Maulana Perdana , Rizki Muhammad Ikhwan , Nor Titin 
Published: February 2022

Kerusakan oksidatif dalam tubuh manusia dapat disebabkan oleh radikal bebas, sehingga menimbulkan berbagai permasalahan. Daun P. canescens memiliki kandungan senyawa fenolik, tanin, alkaloid, steroid, saponin dan flavonoid yang potensial sebagai antioksidan. Tujuan penelitian ini yaitu untuk melakukan uji aktivitas antioksidan dan antitirosinase fraksi n-butanol daun sungkai secara kualittaif menggunakan kromatografi lapis tipis. Metode yang digunakan yaitu preparasi sampel dengan pembuatan simplisia yang kemudian diekstraksi secara maserasi menggunakan etanol 96%. Hasil ekstrak kental kemudian difraksinasi bertingkat dengan pelarut n-heksan, etil asetat, dan n-butanol. Selanjutnya dilakukan skrining fitokimia, uji aktivitas antioksidan, dan antitirosinase secara kualitatif menggunakan kromatografi lapis tipis. Hasil rendemen ekstrak etanol daun P. canescens yaitu sebesar 7,28% sedangkan rendemen fraksi yaitu 24,8%. Skrining fitokimia ekstrak etanol P. canescens mengandung alkaloid, flavonoid, terpenoid, steroid, tanin, saponin, dan fenol. Kesimpulan yang didapatkan dari penelitian ini yaitu fraksi n-butanol daun P. canscens berpotensi memiliki aktivitas antioksidan yang ditandai adanya noda kuning pucat setelah penyemprotan dengan reagen DPPH, serta berpotensi memiliki aktivitas antitirosinase secara kualitatif yang ditandai dengan adanya bercak putih pada plat KLT. Kata Kunci: DPPH, L-DOPA, Asam askorbat, Enzim Oxidative damage in the human body can be caused by free radicals, causing various problems. P. canescens leaves contain phenolic compounds, tannins, alkaloids, steroids, saponins and flavonoids that have potential as antioxidants. The purpose of this study was to test the antioxidant and antityrosinase activity of the n-butanol fraction of sungkai leaves qualitatively using thin layer chromatography. The method used is sample preparation by making simplicia which is then extracted by maceration using 96% ethanol. The viscous extract was then fractionated with n-hexane, ethyl acetate, and n-butanol as solvents. Furthermore, phytochemical screening, antioxidant activity, and antityrosinase tests were carried out qualitatively using thin layer chromatography. The yield of P. canescens leaf ethanol extract was 7.28%, while the fraction yield was 24.8%. Phytochemical screening of P. canescens ethanol extract containing alkaloids, flavonoids, terpenoids, steroids, tannins, saponins, and phenols. The conclusion obtained from this study is that the n-butanol fraction of P. canscens leaves has the potential to have antioxidant activity which is indicated by a pale yellow stain after spraying with DPPH reagent, and has the potential to have qualitative antityrosinase activity which is indicated by the presence of white spots on the TLC plate.
Evaluation of The Distance Learning System Success of Apparatus Training: User Satisfaction Mediation
Authors: Azwar Azwar , Aisyah Siti , Muhammad Adji Suradji 
Published: February 2022

This research aims to find out the influence of system quality and service quality of distance learning system on user satisfaction and the achievement of learning outcomes of trainees during the covid-19 pandemic era at the Financial Education and Training Agency of Makassar. In addition, the study also aims to examine how the role of user satisfaction in mediating the influence of system quality and service quality of distance learning systems on learning outcomes. This study used data obtained from respondents through questionnaires and quantitative approaches through component or variant-based of Structural Equation Modelling (SEM) techniques with Partial Least Square (PLS). The results show that in general the distance learning system has fully run well and successfully based on indicators of DeLone and McLean model. The system quality significantly has positive influence on user satisfaction, service quality significantly has positive influence on user satisfaction and user satisfaction also significantly has positive influence the learning outcomes. Meanwhile, user satisfaction can be a mediator in strengthening the influence of system quality service quality on learning outcomes. Financial Education and Training Agency of Makassar is expected to maintain and improve the quality of systems and services in the existing distance learning system in order to maintain and improve the satisfaction of trainees and learning outcomes.
Exploration The Quality of Knowledge Sharing in Increasing Employees’ Innovative Behavior
Authors: Pratiwi Ratna 
Published: February 2022

Background: Maximizing the innovation potential of employees is a top priority in all companies. New ideas and initiatives generated by employees give the organization a competitive advantage by differentiating and improving products or services. Given the growing importance of intellectual capital in all areas of the company, human resource researchers and professionals are expected to develop and implement effective measures that encourage their employees to innovate. Several factors that can increase employee innovation behavior are the quality of knowledge sharing and its support, namely, employee motivation to learn and transformative leadership.
Purpose: This study was intended to examine the direct effect of learning motivation on employee innovative behaviour and the indirect effect of motivation to learn and transformational leadership in improving the quality of knowledge sharing on increasing employee innovative behaviour.
Originality/value: The novelty of this research is that there is no research on motivation to learn, transformational leadership and knowledge sharing mediation to increase employee innovative behaviour at PT. Indonesia Power Suralaya Power Generation Unit.
Research limitations: The limitation in conducting this research is to explore motivation to learn, transformational leadership mediated by knowledge sharing to increase employee's innovative behaviour.
Design/methodology/approach: The quantitative method using a questionnaire with a 10-point Likert scale was used as a research method. The sampling technique was done by simple random sampling. The number of samples used as many as 63 samples to test four (4) hypotheses that have been determined. In testing the statistical significance of the path coefficient, the Structural Equation Modelling model was used.
Findings: From the research, it was found that motivation to learn had a significant positive effect on innovative behaviour. Motivation to learn has a negative and insignificant effect on knowledge sharing. Transformational leadership has a significant positive effect on knowledge sharing. And knowledge sharing has a significant positive effect on innovative behaviour. The implications of the findings explain that transformational leadership mediates knowledge sharing so that innovative behaviour increases and motivation to learn has a direct influence on increasing innovative behaviour.
Origin of the Miocene Adakitic Rocks and Implication for Tectonic Transition in the Himalayan Orogen: Constraints from Kuday Granitoid Porphyry in Southern Tibet
Authors: Fan Yunsong , Zhang Jinjiang , Lin Chao , Wang Haibing , Gu Daxiang , Wang Xiaoxian , Zhang Bo 
Published: February 2022

Abstract
Postcollisional adakitic magmatism in the Himalayan Orogen provides a probe into the evolution of the collisional orogen. During the Miocene, the Himalayan Orogen underwent a tectonic transition, which was characterized by a series of tectonic events, including the activity of the North-South Trending Rift, exhumation of eclogite, rapid uplift of the orogen, and the extensive adakitic rocks. In this study, we reported the geochemistry and geochronological data of the Kuday dikes intruding into the Tethys Himalayan Sequence near the Sakya Dome of southern Tibet. The Kuday dikes are granitoid porphyries with zircon U-Pb ages of ca. 11 Ma. The Kuday granitoid porphyry dikes have high SiO2 (63.01–68.41 wt.%) and Al2O3 (17.31–19.87 wt.%) but low Mg (0.88–1.41 wt.%), Mg# (36–50), Ni (2.8–19.3 ppm), and Cr (2.9–26.4 ppm), indicating no input of mantle material. They have high Sr (934–1881 ppm), (La/Yb)N (18.84–113.13), and Sr/Y ratios (89.25–305.85) but low K2O/Na2O ratios (0.17–0.79), indicating that they are adakitic affinity. They display initial 87Sr/86Sr ratios of 0.707–0.711 and εNdt values of -3.7–-6.7. These geochemical signatures indicate that the Kuday granitoid porphyrite dikes were derived from the partial melting of the thickened lower crust of the Himalayan Orogen. Partial melting of the thickened lower crust requires additional heat, so the delamination model with lithospheric mantle thinning and asthenospheric upwelling is proposed to explain the formation of the Kuday adakitic rock. The delamination model can also provide a reasonable explanation for the tectonic events during the Miocene in the Himalayan Orogen.
Alpha-power in electroencephalography as good outcome predictor for out-of-hospital cardiac arrest survivors
Authors: Kim Min-Jee , Kim Youn-Jung , Yum Mi-Sun , Kim Won Young 
Published: February 2022

Abstract
This study aimed to identify the quantitative EEG biomarkers for predicting good neurologic outcomes in OHCA survivors treated with targeted temperature management (TTM) using power spectral density (PSD), event-related spectral perturbation (ERSP), and spectral entropy (SE). This observational registry-based study was conducted at a tertiary care hospital in Korea using data of adult nontraumatic comatose OHCA survivors who underwent standard EEG and treated with TTM between 2010 and 2018. Good neurological outcome at 1 month (Cerebral Performance Category scores 1 and 2) was the primary outcome. The linear mixed model analysis was performed for PSD, ESRP, and SE values of all and each frequency band. Thirteen of the 54 comatose OHCA survivors with TTM and EEG, 13 were excluded due to poor EEG quality or periodic/rhythmic pattern, leaving 41 patients for analysis. The median time to EEG was 21 h, and the rate of the good neurologic outcome at 1 month was 52.5%. The good neurologic outcome group was significantly younger and showed higher PSD and ERSP and lower SE features for each frequency than the poor outcome group. After age adjustment, only the alpha-PSD was significantly higher in the good neurologic outcome group (1.13 ± 1.11 vs. 0.09 ± 0.09, p = 0.031) and had best performance with 0.903 of the area under the curve for predicting good neurologic outcome. Alpha-PSD best predicts good neurologic outcome in OHCA survivors and is an early biomarker for prognostication. Larger studies are needed to conclusively confirm these findings.
Effects of Ferula on Polycystic Ovary Syndrome
Authors: Fatemeh Ghavi , Abdolahian Somayeh , Fatemeh Shakeri 
Published: February 2022

Abstract
Background: Polycystic ovarian syndrome is the most common endocrine disorder in reproductive aged women. As a result of side effect of pharmaceutical medications women are interested in using alternative medicines to treat. To determine the comparative effects of Ferula assa-foetida on androgenic hormone levels and ovarian features in patient with polycystic ovarian syndrome (PCOS). Methods: In this triple-blinded controlled clinical trial, 34 student participants were randomly divided in two groups. Intervention group received 100 mg of oleo-gum resin of Ferula assa- foetida, control group received oral paraffin (Placebo) twice daily for 3 months. The efficacy of this herbal medicines was measured after the 3-month intervention. Hormonal assay for evaluating Testosterone, DEHAS, Prolactin, TSH, FSH, LH levels and also trans abdominal ultrasound for evaluating ovarian volumes, number of follicles of both ovaries, and endometrial thickness. Were measured before and after the study. Results: In this study, significant changes in DEHAS and TSH level were observed (p value<0.03). The greatest reduction in the number of ovarian follicles was reported in the Ferula group (p value <0.00). Conclusion: Use of Ferula assa-foetida can be effected in decrease of DHEAS, TSH levels, and ovarian follicles number in young girls with PCOS.
Comparison of the radiomics-based predictive models using machine learning and nomogram for epidermal growth factor receptor mutation status and subtypes in lung adenocarcinoma
Authors: Kawazoe Yusuke , Shiinoki Takehiro , Fujimoto Koya , Yuasa Yuki , Hirano Tsunahiko , Matsunaga Kazuto , Tanaka Hidekazu 
Published: February 2022

Abstract
Introduction: The purpose of this study is to develop the predictive models for epidermal growth factor receptor (EGFR) mutation status and subtypes [exon 21-point mutation (L858R) and exon 19 deletion mutation (19Del)] and validate the clinical effectiveness.Methods: Total 172 patients with lung adenocarcinoma were enrolled. The analysis of variance and the least absolute shrinkage were used feature selection from plain computed tomography images. Then, radiomic score (rad-score) was calculated for the training and test cohorts. Two machine learning (ML) models with 5-fold were applied to construct the predictive models with rad-score and clinical features and evaluated by the area under the curve (AUC) of receiver operating characteristic curve. The nomogram was developed using rad-score and clinical features, then evaluated by the C-index. Finally, decision curve analysis (DCA) was performed using the best ML and nomogram models.Results: The AUC of the best ML models and the C-index of the nomogram models were 0.82, 0.73 and 0.84, 0.78 in the EGFR mutation groups, 0.83, 0.83 and 0.83, 0.80 in the L858R mutation groups, and 0.84, 0.77 and 0.85, 0.69 in the 19Del groups, respectively in the training and test cohorts. DCA showed that nomogram models have more benefits than ML models.Conclusion: We constructed two predictive models for EGFR mutation status and subtypes. The nomogram models had more clinical usefulness than ML models.
E-Consent - a guide to implement an innovative solution to maintain recruitment in clinical trials during the COVID-19 pandemic
Authors: Almeida-Magana Ricardo , Maroof Hanna , Grierson Jack , Clow Rosie , Dinneen Eoin , Al-Hammouri Tarek , Muirhead Nicola , Brew-Graves Chris , Kelly John , Shaw Greg 
Published: February 2022

Abstract
Background:The COVID-19 pandemic has posed daunting challenges for the conduction of clinical research. Adopting new technologies such as remote electronic consent (e-Consent) can help overcome them. However, guidelines for e-Consent implementation in ongoing clinical trials are currently lacking. The NeuroSAFE PROOF trial is a randomised clinical trial evaluating the role of frozen section analysis during RARP for prostate cancer. In response to the COVID-19 crisis, recruitment was halted, and a remote e-Consent solution was designed. The aim of this paper is to describe the process of implementation, impact on recruitment rate and patients’ experience using e-Consent.Methods:A substantial amendment of the protocol granted the creation of a remote e-Consent framework based on the REDCap environment, following the structure and content of the already approved paper consent form. A new pathway was developed which offered continuous support to patients through remote consultations. The whole process was judged to be compliant with regulatory requirements before implementation.Results:Before the first recruitment suspension, NeuroSAFE PROOF was recruiting an average of 9 patients per month. After e-Consent implementation, 63 new patients (4/month) have been enrolled despite a second lockdown, none of whom would have been recruited using the old methods given restrictions on face-to-face consultations. Patients have given positive feedback on the use of the platform. Limited troubleshooting has been required after implementation.Conclusion:Remote e-Consent based recruitment was critical for the continuation of the NeuroSAFE PROOF trial during the COVID-19 pandemic. The described pathway complies with ethical and regulatory guidelines for informed consent, while minimizing face-to-face interactions that increase the risk of COVID-19 transmission. This guide will help researchers integrate e-Consent to ongoing or planned clinical trials while uncertainty about the course of the pandemic continues.Trial registration: The NeuroSAFE PROOF trial has the registration number NCT03317990 (23 October 2017). Regional Ethics Committee; reference 17/LO/1978