bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pioglitazone use in Australia and the United Kingdom following drug safety advisories on bladder cancer risk: An interrupted time series study
Authors: Kemp‐Casey Anna , Mintzes Barbara , Morrow Richard L. , Dormuth Colin R. , Souverein Patrick C. , Roughead Elizabeth E. 
Published: July 2022

AbstractPurposeNational regulators in Australia and the United Kingdom issued safety advisories on the association between pioglitazone use and bladder cancer in July 2011. The Australian advisory noted that males were at higher risk of bladder cancer than females, while the UK advisory highlighted a new recommendation, suggest careful consideration in the elderly due to increasing risk with age. This study examined whether these differences in the advisories had different age‐ and sex‐based impacts in each country.MethodsInterrupted time series analysis was used to compare pioglitazone use (prescriptions/100000 population) in Australia and the United Kingdom for the 24 months before and 11 months after the July 2011 safety advisories (study period July 2009–June 2012). Separate models were used to compare use by sex and age group (≥65 years vs. <65 years) in each country.ResultsPioglitazone use fell in Australia (17%) and the United Kingdom (24%) following the safety advisories. Use of pioglitazone fell more for males (18%) than females (16%) in Australia, and more for females (25%) than males (23%) in the United Kingdom; however, neither difference was statistically significant (Australia p = 0.445, United Kingdom p = 0.462). Pioglitazone use fell to a similar extent among older people than younger people in the United Kingdom (23% vs. 26%, p = 0.354), and did not differ between age groups in Australia (both 18%, p = 0.772).ConclusionsThe results indicate that differences in the Australian and UK safety advisories resulted in substantial reductions in pioglitazone use at the population level in both countries, however, differences by sub‐groups were not observed.
Ameliorating potential of curcumin and its analogue in central nervous system disorders and related conditions: A review of molecular pathways
Authors: Joshi Priyanka , Bisht Akansha , Joshi Sushil , Semwal Deepak , Nema Neelesh Kumar , Dwivedi Jaya , Sharma Swapnil 
Published: July 2022

AbstractCurcumin, isolated from turmeric (Curcuma longa L.) is one of the broadly studied phytomolecule owing to its strong antioxidant and anti‐inflammatory potential and has been considered a promising therapeutic candidate in a wide range of disorders. Considering, its low bioavailability, different curcumin analogs have been developed to afford desired pharmacokinetic profile and therapeutic outcome in varied pathological states. Several preclinical and clinical studies have indicated that curcumin ameliorates mitochondrial dysfunction, inflammation, oxidative stress apoptosis‐mediated neural cell degeneration and could effectively be utilized in the treatment of different neurodegenerative diseases. Hence, in this review, we have summarized key findings of experimental and clinical studies conducted on curcumin and its analogues with special emphasis on molecular pathways, viz. NF‐kB, Nrf2‐ARE, glial activation, apoptosis, angiogenesis, SOCS/JAK/STAT, PI3K/Akt, ERK1/2 /MyD88 /p38 MAPK, JNK, iNOS/NO, and MMP pathways involved in imparting ameliorative effects in the therapy of neurodegenerative disorders and associated conditions.
A scoping review of nutritional interventions and policy guidelines in the interconception period for prevention of noncommunicable diseases
Authors: Watson Daniella , Jacob Chandni M. , Giles Gareth , McAuliffe Fionnuala M. , Godfrey Keith , Hanson Mark 
Published: July 2022

AbstractIntroductionThe interconception period is considered a time when parents are likely to engage with health messages and are in frequent contact with healthcare professionals. Through this scoping review and policy analysis, we synthesized articles and guidelines on interconception care to provide recommendations to improve health outcomes for parents, infants and future generations.MethodsFour databases were searched systematically, using Medical Subject Headings and free‐text terms based on ‘interconception’ and ‘postpartum.’ Selected articles included systematic reviews, pilot studies and guidelines on interconception and postpartum interventions published globally and in English by UK public health organizations and government agencies between 1 January 2010 and 12 January 2021. Thirty percent of titles, abstracts and full‐text papers were double‐screened. The description table of identified guidelines was used as a template to qualitatively generate key categories, which later developed into a framework of six domains. Findings are described using a narrative synthesis approach.ResultsWe found 47 documents with guidelines, 29 systematic reviews and 6 pilot studies on interconception and postpartum care. Six domains were generated as follows: interconception care, nutrition‐specific, nutrition‐sensitive, personal‐centred care, health professional, and multistakeholder approach. Interconception care opportunities include the postpartum period, family planning, routine practice and risk assessments. Health and nonhealthcare professionals with roles to play in the interconception period include general pratitioners, health visitors, dieticians, nutritionists, health psychologists, community groups, local authorities and charities such as Tommy's and First Step Nutrition.ConclusionsThe interconception and postpartum periods offer crucial opportunities to intervene, to reduce possible long‐term effects of suboptimal nutrition. Although the policy analysis for this scoping review focused on the United Kingdom, the literature review had a global focus and the recommendations can have wider implications for other countries.
A novel approach for characterization of multibeam communication payloads
Authors: Trivedi Jatin , Joshi Siddhant , Vyas Rakesh 
Published: July 2022

SummaryCommunication payload architecture has changed from a conventional single broad beam to a large number of spot beam forms to meet the ever‐increasing data rate demand. Owing to the large telecommunication requirements of the user, current generation satellites are equipped with a large number of transponders/beams. Due to the increased number of payload beams, performance evaluation and validation time increases during all stages of the satellite integration process. Also, satellite testing in thermal–vacuum (TVAC) conditions is hugely cost‐intensive. Under such circumstances, the conventional test setup established for multibeam payload characterization presents limitations and increases overall measurement time. The paper proposes a novel switch matrix (SWM) based architecture for integrated multibeam payload characterization at payload input and output to significantly reduce effective uplink and downlink transmission line chains required for RF characterization without compromising overall measurement accuracy. We have developed a Telecommand and Telemetry (TCTM) simulator system for closed‐loop automated switching of switches in SWM to reduce human intervention and ensure safety aspects of payload. We present the SWM approach for two classes of high throughput satellites (HTS), namely, symmetrical and asymmetrical architectures. The results show that the proposed approach is robust and advantageous in overall RF performance, reduction in the number of interfaces, electromagnetic interference and electromagnetic susceptibility (EMI/EMC) considerations, electrical integrity, and ground test setup complexity compared with conventional characterization philosophy.
Real‐Time Interfacial Nanothermometry Using DNA‐PAINT Microscopy
Authors: Nooteboom Sjoerd W. , Wang Yuyang , Dey Swayandipta , Zijlstra Peter 
Published: July 2022

AbstractBiofunctionalized nanoparticles are increasingly used in biomedical applications including sensing, targeted delivery, and hyperthermia. However, laser excitation and associated heating of the nanomaterials may alter the structure and interactions of the conjugated biomolecules. Currently no method exists that directly monitors the local temperature near the material's interface where the conjugated biomolecules are. Here, a nanothermometer is reported based on DNA‐mediated points accumulation for imaging nanoscale topography (DNA‐PAINT) microscopy. The temperature dependent kinetics of repeated and reversible DNA interactions provide a direct readout of the local interfacial temperature. The accuracy and precision of the method is demonstrated by measuring the interfacial temperature of many individual gold nanoparticles in parallel, with a precision of 1 K. In agreement with numerical models, large particle‐to‐particle differences in the interfacial temperature are found due to underlying differences in optical and thermal properties. In addition, the reversible DNA interactions enable the tracking of interfacial temperature in real‐time with intervals of a few minutes. This method does not require prior knowledge of the optical and thermal properties of the sample, and therefore opens the window to understanding and controlling interfacial heating in a wide range of nanomaterials.
A Reliable and Precise Protocol for Urea Quantification in Photo/Electrocatalysis
Authors: Li Dong , Xu Ning , Zhao Yunxuan , Zhou Chao , Zhang Li‐Ping , Wu Li‐Zhu , Zhang Tierui 
Published: July 2022

AbstractTo comply with the trend toward green and sustainable development of the fine chemical industry, multitudinous promising technologies (e.g., photocatalysis and electrocatalysis) are beginning to dabble in the green synthesis of fine chemicals, particularly urea synthesis. Whilst numerous advances are made in mechanistic understanding, the low yield reported so far also imposes more stringent requirements on the reliability and anti‐interference of the detection method. Herein, the applicability of frequently used methods for urea quantification is methodically compared. In terms of the experimental results, a precise and methodical protocol for urea quantification or evaluation in photo/electrocatalysis is explored and established, with emphasis on screening quantitative methods under specific conditions and indispensable isotopic tracing experiments. The budding urea photo/electrosynthesis urgently demands a rigorous protocol, including the rapid isotopic identification and evaluation criteria, capable of promoting healthy development in the future.
Bridging the Gap between Single Nanoparticle Imaging and Global Electrochemical Response by Correlative Microscopy Assisted By Machine Vision
Authors: Godeffroy Louis , Lemineur Jean‐François , Shkirskiy Viacheslav , Miranda Vieira Mathias , Noël Jean‐Marc , Kanoufi Frédéric 
Published: July 2022

AbstractThe nanostructuration of an electrochemical interface dictates its micro‐ and macroscopic behavior. It is generally highly complex and often evolves under operating conditions. Electrochemistry at these nanostructurations can be imaged both operando and/or ex situ at the single nanoobject or nanoparticle (NP) level by diverse optical, electron, and local probe microscopy techniques. However, they only probe a tiny random fraction of interfaces that are by essence highly heterogeneous. Given the above background, correlative multimicroscopy strategy coupled to electrochemistry in a droplet cell provides a unique solution to gain mechanistic insights in electrocatalysis. To do so, a general machine‐vision methodology is depicted enabling the automated local identification of various physical and chemical descriptors of NPs (size, composition, activity) obtained from multiple complementary operando and ex situ microscopy imaging of the electrode. These multifarious microscopically probed descriptors for each and all individual NPs are used to reconstruct the global electrochemical response. Herein the methodology unveils the competing processes involved in the electrocatalysis of hydrogen evolution reaction at nickel based NPs, showing that Ni metal activity is comparable to that of platinum.
A location privacy protection method based on cipher‐text retrieval in cloud environment
Authors: Zhang Yongbing , Zhang Qiuyu , Jiang Yilong , Yan Yan 
Published: July 2022

AbstractIn order to improve the efficiency of location query and the effect of privacy protection in cloud environment, a location privacy protection method based on cipher‐text retrieval was proposed. Firstly, the spatial area is divided into several square grids, and the big Morton code of each location is calculated, the spatial area in the grid is divided again, and the small Morton code of each location is calculated. Secondly, the location data is encrypted by the combination of public key encryption and scrambling encryption, and then outsourced to the cloud server. When querying the location data of the interest points, the query request is sent to the data owner. After obtaining the query trapdoor and the private key, the query trapdoor is sent to the location data server for query. On the server side, the interest points in the region are found according to the cipher‐text matching, and the cipher‐text top‐k sorting is implemented. Finally, the cipher‐text query results are decrypted into plaintext by the private key. Experimental results show that the proposed method ensures the location data privacy, and improves query efficiency. At the same time, the balance between privacy protection security and query quality is achieved.
Monitor wind characteristics and wind‐induced responses of a skyscraper during two typhoons
Authors: Cao Jixing , Xiong Haibei , Qin Xiaoming 
Published: July 2022

SummarySkyscrapers are wind‐sensitive structures due to their large slenderness ratio and good flexibility. Understanding the wind characteristics and wind‐induced response from the actual data provides first‐hand information for wind resistance design. This paper reports the wind properties and dynamic performance of a 632 m high‐rise building in Shanghai during the passage of typhoons Jongdari and Rumbbia. Field measurements obtained from the structural health monitoring system include acceleration and wind speed. The data analysis of turbulence intensity, turbulence integral length, and gust factor are compared and discussed. For the identification of dynamic characteristics, the stochastic subspace method and enhanced frequency domain decomposition method are employed to identify the modal parameters. Besides, the comfort assessment using peak value and root mean square of accelerations is compared with different standards. Studying the wind characteristics during the passage of typhoons and their impact on high‐rise buildings in a metropolis is expected to gain an insight into the dynamic mechanism of high‐rise buildings and collect a database for wind resistance design in typhoon‐prone regions.
A collection and categorization of open‐source wind and wind power datasets
Authors: Effenberger Nina , Ludwig Nicole 
Published: July 2022

AbstractWind power and other forms of renewable energy sources play an ever more important role in the energy supply of today's power grids. Forecasting renewable energy sources has therefore become essential in balancing the power grid. While a lot of focus is placed on new forecasting methods, little attention is given on how to compare, reproduce and transfer the methods to other use cases and data. One reason for this lack of attention is the limited availability of open‐source datasets, as many currently used datasets are non‐disclosed and make reproducibility of research impossible. This unavailability of open‐source datasets is especially prevalent in commercially interesting fields such as wind power forecasting. However, with this paper, we want to enable researchers to compare their methods on publicly available datasets by providing the, to our knowledge, largest up‐to‐date overview of existing open‐source wind power datasets, and a categorization into different groups of datasets that can be used for wind power forecasting. We show that there are publicly available datasets sufficient for wind power forecasting tasks and discuss the different data groups properties to enable researchers to choose appropriate open‐source datasets and compare their methods on them.
Corporate investment prediction using a weighted temporal graph neural network
Authors: Li Jianing , Yao Xin 
Published: July 2022

AbstractCorporate investment is an important part of corporate financial decision‐making and affects the future profit and value of the corporation. Predicting corporate investment provides great significance for capital market investors to understand the future operation and development of a corporation. Many researchers have studied independent prediction methods. However, individual firms imitate each other's investment in the actual decision‐making process. This phenomenon of investment convergence indicates investment correlation among individual firms, which is ignored in these existing methods. In this article, we first identify key variables in multivariate sequences by our designed two‐way fixed effects model for precise corporate network construction. Then, we propose a weighted temporal graph neural network called weighted temporal graph neural network (WTGNN) for graph learning and investment prediction over the corporate network. WTGNN improves the graph convolution capability by weighted sampling with attention and multivariate time series aggregation. We conducted extensive experiments using real‐world financial reporting data. The results show that WTGNN can achieve excellent graph learning performance and outperforms existing methods in the investment prediction task.This article is categorized under:
Technologies > Prediction
Technologies > Machine Learning
Application Areas > Business and Industry
The Framework Convention on Tobacco Control (FCTC) and implementation of tobacco control policies: Lessons learned from Indonesia and Thailand
Authors: Moeis Faizal Rahmanto , Nurhasana Renny , Rahardi Fandy , Novitasari Danty , Shellasih Ni Made , Inayati  , Murwendah  , Suriyawongpaisal Paibul , Patanavanich Roengrudee , Ratih Suci Puspita 
Published: July 2022

AbstractThe threat that the tobacco epidemic poses to public health underscores the importance of comprehensive tobacco‐related regulation. Despite aiming to reduce the prevalence of smoking, Indonesia still falls short of this goal. In contrast, within the same region, Thailand's achievement in controlling tobacco serves as a potential role model for Indonesia. To understand the issue, we conducted a literature review of the current regulatory framework as well as the implementation of the World Health Organization's Framework Convention on Tobacco Control (FCTC) and MPOWER framework in both countries. The review was supplemented with a Focus Group Discussion and an in‐depth interview with stakeholders in Thailand and Indonesia. This study finds that: (1) Indonesia currently lacks a strong tobacco control policy champion, whereas Thailand has several authorities that focus on the issue; (2) Thailand's tobacco product advertising and promotion and smoking bans are more restrictive compared to Indonesia's policies; and (3) Thailand's policies on tobacco pictorial health warnings, pharmacotherapy, and excise taxes are more extensive than Indonesia's. We recommend that Indonesia ratify the FCTC as the foundation of tobacco control policies while also strengthening and coordinating organizations working on tobacco control, encouraging subnational governments to introduce regulations, and enforce control, as well as improving excise policies to reduce the affordability of tobacco products.
Abschließende Bewertung – Planspiele als eine geeignete didaktische Methode zum Einstieg in das Thema Ressourceneffizienz
Authors: Anstätt Kerstin , Schmidt Mario , Bertagnolli Frank 
Published: July 2022

ZusammenfassungIn diesem Kapitel wird der Einsatz von Planspielen als didaktische Methode in der Weiterbildung abschließend bewertet. Die Praxisanwendung der Spiele hat gezeigt, dass Planspiele einen guten Einstieg in das Thema Ressourceneffizienz darstellen und im Spiel wichtige Impulse zur weiteren Umsetzung im Unternehmen gegeben werden können.
RE:GEBÄUDE – das Planspiel zu Energieeffizienz in Verwaltungsgebäuden
Authors: Grund Ernst , Gehrung Katja 
Published: July 2022

ZusammenfassungDas Planspiel RE:GEBÄUDE (Abb. 7.1) vermittelt den Spielern Wissen zur Energierelevanz von Verwaltungsgebäuden. In dem Planspiel werden für die Spieler die Zusammenhänge und Wechselbeziehungen von Energieeinsparungen und gebäudebezogenen Querschnittstechnologien sichtbar. Es wird dabei deutlich, wie wichtig das Einbeziehen aller Beschäftigten im Unternehmen ist. Das haptische Spielbrett ermöglicht es den Spielern, energetische Potenziale zu erleben.Während des Spiels werden in Teams verschiedene Maßnahmen umgesetzt, welche die Energieeffizienz des Gebäudes verbessern und damit CO2 reduzieren. Dabei lernen die Spieler Zusammenhänge zwischen ökologischen und ökonomischen Potenzialen besser kennen.Weiterhin wird durch die interaktive Gestaltung des Planspiels die Kommunikations- und Sozialkompetenz aller Spieler gestärkt. Durch das Planspiel werden die Spieler animiert, das vermittelte Wissen in den eigenen Unternehmensalltag zu übertragen.
Lokaltherapeutisches Vorgehen bei Blasen der Haut: Ein Positionspapier der Initiative Chronische Wunden (ICW) e. V.
Authors: Dissemond Joachim , Bültemann Anke , Gerber Veronika , Motzkus Martin , Münter Christian , Erfurt-Berge Cornelia 
Published: July 2022

ZusammenfassungBlasen an der Haut können durch sehr unterschiedliche Krankheitsbilder verursacht werden. Daher handelt es sich hierbei um eine interdisziplinär und interprofessionell relevante Herausforderung. Im klinischen Alltag werden derzeit verschiedene lokaltherapeutische Vorgehensweisen praktiziert. Entweder wird die Blase belassen oder die Blase wird punktiert und das Blasendach wird belassen, alternativ wird das komplette Blasendach abtragen. Jede dieser Vorgehensweisen hat potenzielle Vor- und Nachteile. Es erfolgte die Durchsicht der aktuellen Literatur und Konsensfindung durch die Expert*innen der Initiative Chronische Wunden (ICW) e. V. Folgende Vorgehensweisen werden empfohlen: unkomplizierte Blasen ohne Druckschmerz: Blasen belassen; druckschmerzhafte sowie palmar und plantar lokalisierte Blasen: Blase punktieren und Dach belassen; rupturierte Blasen ohne klinische Infektionszeichen: Reste des Blasendachs belassen; rupturierte Blasen mit klinischen Infektionszeichen: Reste des Blasendachs abtragen; Blasen bei Verbrennungen ab Grad 2a oder bei unklarer Verbrennungstiefe oder bei chemischer Verbrennung: Blasendach abtragen. Anschließend erfolgt jeweils die Anlage eines sterilen Wundverbandes. Beim Auftreten von Blasen an der Haut gibt es nicht die eine richtige lokaltherapeutische Vorgehensweise. Bei der Planung eines Behandlungskonzepts sollte die Genese der Blasen geklärt werden, ggf. sollte eine kausale Behandlung erfolgen. Die Lokaltherapie orientiert sich dann an verschiedenen individuellen Faktoren. Somit kann das gemeinsam mit den Patient*innen gewählte Vorgehen interindividuell sehr unterschiedlich sein.