bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Antara Interaksi Sosial Teman Sebaya Dengan Kepercayaan Diri Remaja di SMKN 3 Kota Bima
Authors: R Yuli , Sarbudin Sarbudin , Irham Irham , Faijin Faijin 
Published: May 2022

Penelitian ini dilatarbelakangi oleh adanya keterkaitan interaksi peserta didik dengan teman sebayanya. Peserta didik jurusan tata boga yang jarang bergaul dan berinteraksi dengan temannya cenderung minder serta malu untuk berbicara karena tidak terbiasa melakukan interaksi dengan teman sebaya, sehinga terlihat seperti kurang kepercayaan diri untuk bersosial dengan teman sebayanya. Tujuan yang hendak dicapai dalam penelitian adalah untuk mengetahui hubungan antara interaksi sosial teman sebaya dengan kepercayaan diri pada remaja di smkn 3 kota bima tahun pelajaran 2021/2022. Rancangan penelitian adalah penelitian kuantitatif korelasional, sebab penelitian ini bertujuan untuk mengetahui seberapa kuat pengaruh antara dua variabel. Kedua variabel yang dimaksud adalah interaksi sosial teman sebaya bertindak sebagai variabel bebas (X) dan kepercayaan diri peserta didik bertindak sebagai variabel terikat (Y). Adapun yang menjadi populasi dalam penelitian ini ada di beberapa jurusan di SMKN 3 Kota Bima Tahun Pelajaran 2021 yang berjumlah -100 orang peserta didik, Adapun sampel dalam penelitian ini 20 % dari populasi yaitu sebanyak 17 peserta didik. Cara pengambilan sampel menggunakan simple random sampling. Instrumen penelitian yang digunakan berupa angket. Analisis data dengan menggunakan rumus Korelasi Product Moment. Berdasarkan hasil penelitian tentang hubungan antara interaksi sosial teman sebaya dengan percaya diri pada remaja di SMKN 3 Kota Bima tahun pelajaran 2021/2022, maka penulis dapat simpulkan bahwa: interaksi sosial teman sebaya dengan percaya diri pada remaja memiliki hubungan yang erat sebesar 6.059 dengan percaya diri pada remaja, sedangkan sisanya dipengaruhi oleh faktor-faktor lain yang tidak dimasukkan dalam penelitian ini. Yang berarti hipotesis alternatif (Ha diterima).
Keanekaragaman Cyperaceae Di Kawasan Persawahan Desa Beringin Kencana Kecamatan Tabunganen Kalimantan Selatan
Authors: Dari Cici Ayu Wulan , Hardiansyah Hardiansyah , Noorhidayati Noorhidayati 
Published: May 2022

Cyperaceae merupakan tumbuhan familia teki-tekian, berhabitus herba, batangnya kebanyakan berbentuk segitiga dengan bunga majemuk. Cyperaceae banyak ditemukan di kawasan persawahan. Penelitian ini bertujuan untuk mendeskripsikan keanekaragaman .Cyperaceae di kawasan persawahan Desa Beringin Kencana Kecamatan Tabunganen. Penelitian ini menggunakan metode deskriptif dengan teknik pengambilan sampel secara jelajah dengan metode line transect. Hasil Penelitian Keanekaragaman Cyperaceae di kawasan persawahan Desa Beringin Kencana Kecamatan Tabunganen didapatkan 5 genus, yaitu Cyperus berjumlah 4, Fuirena berjumlah 2, Eleocharis berjumlah 1, Fimbristylis berjumlah 1, dan Scleria berjumlah 1 dengan jumlah 9 spesies, yaitu Cyperus polystachyos, C. odoratus, C. rotundus, C. sphacelatus, Fuirena simplex, F. umbellata, Eleocharisrdulcis, Fimbristylis miliacea, dan Scleria sumatrenisis
Pengaruh Model Pembelajaran Picture And Picture Terhadap Motivasi Belajar dan Retensi Biologi Peserta Didik Kelas X MIA SMA Negeri 2 Majene
Authors: Sainab Sainab 
Published: May 2022

Penelitian ini merupakan penelitian Quasi Eksperimen dengan menggunakan desain control group pre-test-post-tes yang bertujuan untuk mengetahui pengaruh model pembelajaran Picture And Picture terhadap motivasi belajar dan retensi peserta didik kelas X MIA SMA Negeri 2 Majene. Sampel pada penelitian ini adalah kelas X MIA3 dan kelas X MIA4 yang diambil dengan menggunakan purposive sampling dengan asumsi bahwa kelas yang diambil homogen. Instrumen yang digunakan dalam penelitian ini berupa angket motivasi untuk mengukur motivasi belajar peserta didik dan tes retensi untuk mengukur retensi (Ijpe). Analisis data uji hipotesis menggunakan uji-z. Hasil uji- z data motivasi diperoleh Zhitung>Ztabel= 4.88>1.96 dengan nilai signifikasi 5%, maka Ho ditolak dan H1 diterima. Data Hasil retensi menggunakan uji z diperoleh nilai 3.68>1.96 dengan nilai signifikasi 5%, dimana Zhitung>Ztabel, maka Ho ditolak dan H1 diterima. Hal ini menunjukkan bahwa terdapat pengaruh model pembelajaran Picture and picture terhadap motivasi belajar dan retensi peserta didik kelas X MIA SMA Negeri 2 Majene.
PENGARUH KESEJAHTERAAN EKONOMI, PELATIHAN DAN MOTIVASI BERPERESTASI TERHADAP KOMPETENSI GURU EKONOMI
Authors: Agussalim Agussalim 
Published: May 2022

Kompetensi guru adalah gambaran pengetahuan dan pemahaman guru sebagai tenaga pendidik yang profesional. Kompetensi guru merupakan gambaran mengenai kualitas proses pembelajaran. Penguasaan kompetensi secara garis besar dipengaruhi oleh kesejahteraan ekonomi, pelatihan dan motivasi berprestasi guru dalam menjalan tugas dan kehidupan sosial. Tujuan penelitian ini adalah untuk mendeskripsikan mengenai sudi empiris pengaruh kesejahteraan ekonomi, pelatihan dan motivasi berprestasi terhadap kompetensi guru ekonomi. Ada beberapa perubahan dilakukan terutama mengenai rujukan internasional untuk memperkuat teori dan hasil penelitian ini. Subjek penelitian adalah guru ekonomi SMA se-Kota Bima berjumlah 48 orang. Instrumen penelitian ini adalah (1) kuesioner terhadap kesejahteraan ekonomi, pelatihan dan motivasi berprestasi; dan (2) soal pilihan ganda untuk mengungkap penguasaan kompetensi guru ekonomi. Kemudian data dianalisis dengan memnggunakan regresi linier berganda. Hasil penelitian menujukan; (1) kesejahteraan ekonomi tergolong rendah, (2) pelatihan tergolong rendah; (3) motivasi berprestasi tergolong cukup tinggi; dan (4) kompetensi guru ekonomi tergolong cukup tinggi. Hasil pengujian hipotesis menunjukan bahwa kesejahteraan ekonomi, pelatihan dan mtovasi berprestasi berpengaruh signifikan dan positif terhadap kompetensi guru ekonomi, dan kesejahteraan ekonomi sebagai model terbaik dan signifikan dalam mempengaruhi kompetensi guru ekonomi. Rekomendasi penelitian ini adalah dalam rangka kebijakan pengembangan kompetensi guru paling utama yaitu meningkatkan kesejahteraan ekonomi berikut motivasi berprestasi dan pelatihan.
STUDI IMPLEMENTASI PENGELOLAAN DAN PENGUSAHAAN BURUNG WALET HABITAT ALAMI DI DUSUN PASIR PUTIH DESA BAJO PULAU KECAMATAN SAPE KABUPATEN BIMA
Authors: Mukhsin Zainuddin , Mukhlis Mukhlis , Hidayat Indra Arif 
Published: May 2022

Tujuan dalam penelitian ini adalah untuk mengetahui Bagaimana Implementasi Pengelolaan Dan Pengusahaan Burung Walet Habitat Alami di Dusun Pasir Putih Desa Bajo Pulau Kecamatan Sape Kabupaten Bima. Metode penelitian yang digunakan adalah metode kualitatif. Jadi menurut pendekatan ini, kawasan penelitian dilihat sebagai kenyataan hidup yang dinamis, memiliki pikiran dan perasaan serta subjektif yang unik, sehingga dalam pendekatan ini data yang diperoleh tidak mesti angka atau data-data yang bisa digunakan. Pendekatan yang digunakan dalam penelitian ini menggunakan pendekatan deskriptif-analitik yaitu suatu pendekatan dalam meneliti status kelompok usaha, kawasan, kondisi, suatu peristiwa maupun kelas peristiwa pada masa sekarang.. Data yang dikumpulkan berupa kata-kata, gambar dan bukan angka. Data yang mungkin berasal dari naskah wawancara, catatan lapangan, dokumen dan sebagainya dideskripsikan sehingga dapat memberikan kejelasan terhadap kenyataan atau realitas. Dalam proses analisis data, dalam penelitian ini digunakan konstruksi tiga alur, yaitu dengan reduksi data, penyajian data dan penarikan kesimpulan. Dari hasil pembahasan maka peneliti menyimpulkan bahwa mengacu Peraturan Bupati Bima Nomor 08 Tahun 2010. Tentang; perubahan atas Peraturan Bupati Bima Nomor 631 Tahun 2005 tenang petunjuk tender pengelolaan dan pengusahaan sarang burung walet (colla calia) yang termuat dalam surat keputusan Kontrak Pengelolaan dan Pengusahaan Gua Sarang Burung Walet Kecamatan Sape dan Kecamatan Lambu Kabupaten Bima Nomor: 03.3/025/369/03.4/2017 pasal 4 tentan kewajiban pihak kedua poin 3) Memanfaatkan tenaga kerja setempat (lokal) dalam kegiatan pengelolaan , poin 5) Memberikan program-program sosial yang dapat memberikan kontribusi kepada masyarakat setempat tidak diaplikasikan oleh pihak kedua CV. Samudra matahari sehingga terjadi penyimpangan peraturan pengelolaan dan pengusahaan sarang burung walet (colla calia) dengan pelaksanaan peraturan yang diberlakukan oleh CV. Samudra matahari, seharusnya masyarakat pribumi juga harus mengetahui dan ikut terlibat dalam pengelolaan dan pengusahaan sarang burung walet (colla calia) dengan tujuan diperhatikannya penduduk setempat baik secara geografis, sosial, budaya, politik dan ekonomi
Biomechanical Effects of 3D-Printed Bioceramic Scaffolds With Porous Gradient Structures on the Regeneration of Alveolar Bone Defect: A Comprehensive Study
Authors: Yang Zhuohui , Wang Chunjuan , Gao Hui , Jia Lurong , Zeng Huan , Zheng Liwen , Wang Chao , Zhang Hongmei , Wang Lizhen , Song Jinlin , Fan Yubo 
Published: May 2022

In the repair of alveolar bone defect, the microstructure of bone graft scaffolds is pivotal for their biological and biomechanical properties. However, it is currently controversial whether gradient structures perform better in biology and biomechanics than homogeneous structures when considering microstructural design. In this research, bioactive ceramic scaffolds with different porous gradient structures were designed and fabricated by 3D printing technology. Compression test, finite element analysis (FEA) revealed statistically significant differences in the biomechanical properties of three types of scaffolds. The mechanical properties of scaffolds approached the natural cancellous bone, and scaffolds with pore size decreased from the center to the perimeter (GII) had superior mechanical properties among the three groups. While in the simulation of Computational Fluid Dynamics (CFD), scaffolds with pore size increased from the center to the perimeter (GI) possessed the best permeability and largest flow velocity. Scaffolds were cultured in vitro with rBMSC or implanted in vivo for 4 or 8 weeks. Porous ceramics showed excellent biocompatibility. Results of in vivo were analysed by using micro-CT, concentric rings and VG staining. The GI was superior to the other groups with respect to osteogenicity. The Un (uniformed pore size) was slightly inferior to the GII. The concentric rings analysis demonstrated that the new bone in the GI was distributed in the periphery of defect area, whereas the GII was distributed in the center region. This study offers basic strategies and concepts for future design and development of scaffolds for the clinical restoration of alveolar bone defect.
Therapeutic Effects of Zoledronic Acid-Loaded Hyaluronic Acid/Polyethylene Glycol/Nano-Hydroxyapatite Nanoparticles on Osteosarcoma
Authors: Xu Yan , Qi Jingqi , Sun Wei , Zhong Wu , Wu Hongwei 
Published: May 2022

Zoledronic acid (ZOL) has been approved as the only bisphosphonate for the prevention and treatment of metastatic bone diseases with acceptable safety and tolerability. However, systemic or direct injection of ZOL often causes severe side effects, which limits its clinical application. Here, an innovative nano-drug delivery system, ZOL-loaded hyaluronic acid/polyethylene glycol/nano-hydroxyapatite nanoparticles (HA-PEG-nHA-ZOL NPs), has been found to effectively inhibit the proliferation of three types of human osteosarcoma cell lines (143b, HOS, and MG63) at 1–10 μmol/L, while with low cell cytotoxicity on normal cells. The NPs significantly enhanced the apoptosis-related protein expression and tumor cell apoptosis rate. The NPs could also inhibit the proliferation of osteosarcoma cells by blocking the S phase of the cell cycle. In the orthotopic osteosarcoma nude mice model, local injection of the HA-PEG-nHA-ZOL NPs stimulated tumor necrosis, apoptosis, and granulocyte infiltration in the blood vessels. Altogether, the ZOL nano-delivery system possesses great potential for local treatment to prevent local tumor recurrence and can be applied in clinical osteosarcoma therapy.
Selecting for Feed Efficient Cows Will Help to Reduce Methane Gas Emissions
Authors: Manzanilla-Pech Coralia Ines Valentina , Stephansen Rasmus Bak , Difford Gareth Frank , Løvendahl Peter , Lassen Jan 
Published: May 2022

In the last decade, several countries have included feed efficiency (as residual feed intake; RFI) in their breeding goal. Recent studies showed that RFI is favorably correlated with methane emissions. Thus, selecting for lower emitting animals indirectly through RFI could be a short-term strategy in order to achieve the intended reduction set by the EU Commission (-55% for 2030). The objectives were to 1) estimate genetic parameters for six methane traits, including genetic correlations between methane traits, production, and feed efficiency traits, 2) evaluate the expected correlated response of methane traits when selecting for feed efficiency with or without including methane, 3) quantify the impact of reducing methane emissions in dairy cattle using the Danish Holstein population as an example. A total of 26,664 CH4 breath records from 647 Danish Holstein cows measured over 7 years in a research farm were analyzed. Records on dry matter intake (DMI), body weight (BW), and energy corrected milk (ECM) were also available. Methane traits were methane concentration (MeC, ppm), methane production (MeP; g/d), methane yield (MeY; g CH4/kg DMI), methane intensity (MeI; g CH4/kg ECM), residual methane concentration (RMeC), residual methane production (RMeP, g/d), and two definitions of residual feed intake with or without including body weight change (RFI1, RFI2). The estimated heritability of MeC was 0.20 ± 0.05 and for MeP, it was 0.21 ± 0.05, whereas heritability estimates for MeY and MeI were 0.22 ± 0.05 and 0.18 ± 0.04, and for the RMeC and RMeP, they were 0.23 ± 0.06 and 0.16 ± 0.02, respectively. Genetic correlations between methane traits ranged from moderate to highly correlated (0.48 ± 0.16–0.98 ± 0.01). Genetic correlations between methane traits and feed efficiency were all positive, ranging from 0.05 ± 0.20 (MeI-RFI2) to 0.76 ± 0.09 (MeP-RFI2). Selection index calculations showed that selecting for feed efficiency has a positive impact on reducing methane emissions’ expected response, independently of the trait used (MeP, RMeP, or MeI). Nevertheless, adding a negative economic value for methane would accelerate the response and help to reach the reduction goal in fewer generations. Therefore, including methane in the breeding goal seems to be a faster way to achieve the desired methane emission reductions in dairy cattle.
Veno-Arterial Extracorporeal Membrane Oxygenation in Elective High-Risk Percutaneous Coronary Interventions
Authors: Bai Ming , Lu Andong , Pan Chenliang , Hu Sixiong , Qu Wenjing , Zhao Jing , Zhang Bo 
Published: May 2022

BackgroundThe safety and feasibility of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) as mechanical circulatory support in high-risk percutaneous coronary intervention (HR-PCI) remain unclear.MethodsThis retrospective study included patients with complex and high-risk coronary artery disease who underwent elective PCI with VA-ECMO support pre-operatively during March 2019–December 2020. Rates of VA-ECMO-related complications, complications during PCI, death, myocardial infarction, and stroke during hospitalisation and 1-year post-operatively were analysed.ResultsOverall, 36 patients (average age: 63.6 ± 8.9 years) underwent PCI. The average duration of VA-ECMO support was 12.5 (range, 3.0–26.3) h. Intra-aortic balloon pump counterpulsation was used in 44.4% of patients. The SYNTAX score was 34.6 ± 8.4 pre-operatively and 10.8 ± 8.8 post-operatively (P &lt; 0.001). Intraoperative complications included pericardial tamponade (N = 2, 5.6%), acute left-sided heart failure (N = 1, 2.8%), malignant arrhythmia requiring electrocardioversion (N = 2, 5.6%), and no deaths. Blood haemoglobin levels before PCI and 24 h after VA-ECMO withdrawal were 145.4 ± 20.2 g/L and 105.7 ± 21.7 g/L, respectively (P &lt; 0.001). Outcomes during hospitalisation included death (N = 1, 2.8%), stroke (N = 1, 2.8%), lower limb ischaemia (N = 2, 5.6%), lower limb deep venous thrombosis (N = 1, 2.8%), cannulation site haematoma (N = 2, 5.6%), acute renal injury (N = 2, 5.6%), bacteraemia (N = 2, 5.6%), bleeding requiring blood transfusion (N = 5, 13.9%), and no recurrent myocardial infarctions. Within 1 year post-operatively, two patients (5.6%) were hospitalised for heart failure.ConclusionsVeno-arterial extracorporeal membrane oxygenation mechanical circulation support during HR-PCI is a safe and feasible strategy for achieving revascularisation in complex and high-risk coronary artery lesions. VA-ECMO-related complications require special attention.
Classification of Children's Heart Sounds With Noise Reduction Based on Variational Modal Decomposition
Authors: Zhang Anqi , Wang Jiaming , Qu Fei , He Zhaoming 
Published: May 2022

PurposeChildren's heart sounds were denoised to improve the performance of the intelligent diagnosis.MethodsA combined noise reduction method based on variational modal decomposition (VMD) and wavelet soft threshold algorithm (WST) was proposed, and used to denoise 103 phonocardiogram samples. Features were extracted after denoising and employed for an intelligent diagnosis model to verify the effect of the denoising method.ResultsThe noise in children's phonocardiograms, especially crying noise, was suppressed. The signal-to-noise ratio obtained by the method for normal heart sounds was 14.69 dB at 5 dB Gaussian noise, which was higher than that obtained by WST only and the other VMD denoising method. Intelligent classification showed that the accuracy, sensitivity and specificity of the classification system for congenital heart diseases were 92.23, 92.42, and 91.89%, respectively and better than those with WST only.ConclusionThe proposed noise reduction method effectively eliminates noise in children's phonocardiograms and improves the performance of intelligent screening for the children with congenital heart diseases.
Size-Dependent Interplay of Volume Exclusion Versus Soft Interactions: Cytochrome c in Macromolecular Crowded Environment
Authors: Parray Zahoor Ahmad , Ahmad Faizan , Chaudhary Anis Ahmad , Rudayni Hassan Ahmad , Al-Zharani Mohammed , Hassan Md. Imtaiyaz , Islam Asimul 
Published: May 2022

Even though there are a great number of possible conformational states, how a protein generated as a linear unfolded polypeptide efficiently folds into its physiologically active form remained a fascinating and unanswered enigma inside crowded conditions of cells. In this study, various spectroscopic techniques have been exploited to know and understand the effect and mechanism of action of two different sizes of polyethylene glycols, or PEGs (molecular mass ∼10 and ∼20 kilo Daltons, kDa), on cytochrome c (cyt c). The outcomes showed that small size of the PEG leads to perturbation of the protein structure, and conversely, large size of the PEG has stabilizing effect on cyt c. Moreover, binding measurements showed that small size of PEG interacts strongly via soft interactions compared to the larger size of PEG, the latter being governed more by excluded volume effect or preferential exclusion from the protein. Overall, this finding suggests that conformations of protein may be influenced in cellular crowded conditions via interactions which depend upon the size of molecule in the environment. This study proposes that both volume exclusion and soft (chemical) interactions governs the protein’s conformation and functional activities. The cellular environment’s internal architecture as evident from crowder size and shape in this study has a significant role.
Dietary Acid Load Is Positively Associated With Risk of Gestational Diabetes Mellitus in a Prospective Cohort of Chinese Pregnant Women
Authors: Zhao Rui , Zhou Leilei , Lei Gang , Wang Shanshan , Li Yan , Yang Xuefeng , Xiong Guoping , Hao Liping 
Published: May 2022

BackgroundGrowing evidence suggests that dietary acid load plays an important role in the development of type 2 diabetes. However, prospective studies on the relationship between dietary acid load and gestational diabetes mellitus (GDM) are limited in the pregnant population. This study aimed to investigate the effect of dietary acid load during early pregnancy on the risk of GDM in Chinese pregnant women.MethodsA total of 1,327 pregnant women were enrolled from an ongoing prospective study of the Tongji Birth cohort (TJBC) in Wuhan, China. Dietary intake was assessed before 20 weeks using a 74-item semiquantitative food frequency questionnaire (FFQ). The dietary acid load was estimated using potential renal acid load (PRAL), net endogenous acid production (NEAP), and animal protein to potassium ratio (A:P ratio). A 75g 2-h oral glucose tolerance test (OGTT) was performed at 24-28 gestational weeks to diagnose GDM.ResultsThe mean (standard deviation) values for PRAL score, NEAP score, and A:P ratio were 0.8 ± 11.3 mEq/day, 45.3 ± 16.5 mEq/day, and 9.8 ± 6.0, respectively. There was a significant positive correlation of dietary acid load with the intake of red meat, poultry, fish, and eggs, and a negative correlation with the intake of vegetables, fruits, nuts, and legumes (all P &lt; 0.05). Compared to the lowest tertile, the highest tertile of dietary acid load, including PRAL score (odds ratio [OR]: 2.26, 95% confidence interval [CI] = 1.38–3.71, P-trend = 0.002), NEAP score (OR: 2.02, 95% CI = 1.25–3.27, P-trend = 0.009), and A:P ratio (2.08, 95% CI = 1.30–3.31, P-trend = 0.005), significantly increased the risk of GDM. In addition, the dietary acid load was also significantly associated with an increase in 1-h and 2-h post-load blood glucose concentrations (all P-trend &lt; 0.05).ConclusionWe found a significant positive association between dietary acid load during early pregnancy and the risk of GDM in a Chinese population, suggesting that the reduction of food sources of dietary acid load may be an effective strategy for preventing the risk of GDM.
Anlotinib for Recurrent or Metastatic Primary Malignant Bone Tumor: A Multicenter, Single-Arm Trial
Authors: Tang Lina , Niu Xiaohui , Wang Zhen , Cai Qiqing , Tu Chongqi , Fan Zhengfu , Yao Yang 
Published: May 2022

ObjectiveAnlotinib, a novel multitarget kinase inhibitor of VEGFR, FGFR, PDGFR and c-Kit, has proven to be effective and safe for refractory soft tissue sarcoma patients, but has not been examined in recurrent or metastatic primary malignant bone tumors in a clinical trial setting.MethodsThis is a multicenter single-arm trial. Patients with pathologically proven recurrent or metastatic primary malignant bone tumors were eligible. Anlotinib was administered orally at 12 mg per day. Each cycle consisted of 2 weeks of treatment followed by 1-week off-treatment. The primary endpoint was progression-free survival (PFS), as assessed in the intention-to-treat (ITT) population. Secondary endpoints included objective response rate (ORR), disease control rate (DCR) and overall survival (OS). Adverse events (AEs) were assessed per NCI CTCAE version 4.03.ResultsA total of 42 patients were enrolled. Median PFS was 5.3 months (95% CI 3.5-8.4 months) in the overall analysis, 4.8 months (95%CI 3.5-7.1 months) in osteosarcoma patients and 2.8 months [95%CI 1.3 months to not reached (NR)] in chondrosarcoma patients. The median OS was 11.4 months (95% CI 10.1 months to NR) in the overall analysis, not reached (95% CI, NR, NR) in osteosarcoma patients and 11.4 months (95% CI 1.8 to 21.1 months) in chondrosarcoma patients. The ORR was 9.52% and DCR was 78.57%. Grade 3 or above AEs occurred in 54.76% of the patients, and included hypertension (19.05%), hypertriglyceridemia (9.52%) and pustulosis palmaris et plantaris (7.14%). No treatment-related death was reported.ConclusionAnlotinib demonstrated promising antitumor activities in recurrent or metastatic primary malignant bone tumors with manageable AEs.