bluuebunny/crossref_metadata_2025_split huggingface dataset:
EDIL3 influenced the αvβ3‐FAK/MEK/ERK axis of endothelial cells in psoriasis
Authors: Niu Xuping , Han Qixin , Li Xinhua , Li Juan , Liu Yanmin , Li Yan , Wu Yan , Zhang Kaiming 
Published: September 2022

AbstractOne of the earliest events in the development of psoriatic lesion is a vascular network expansion. The abnormal vascular network is associated with increased endothelial cells (ECs) survival, proliferation, adhesion, migration, angiogenesis and permeability in psoriatic lesion. Our previous study demonstrated that epidermal growth factor‐like repeats and discoidin I‐like domains 3 (EDIL3) derived from psoriatic dermal mesenchymal stem cells (DMSCs) promoted cell–cell adhesion, migration and angiogenesis of ECs, but the molecular mechanism of upstream or downstream has not been explored. So, this study aimed to explore the association between EDIL3 derived from DMSCs (DMSCs‐derived EDIL3) and psoriasis‐associated angiogenesis. We injected recombinant EDIL3 protein to mouse model of psoriasis to confirm the roles of EDIL3 in psoriasis. Besides, we employed both short‐interference RNA (si‐RNA) and lentiviral vectors to explore the molecular mechanism of EDIL3 promoting angiogenesis in psoriasis. In vivo, this research found that after injected recombination EDIL3 protein, the epidermis thickness and microvessel density were both elevated. EDIL3 accelerated the process of psoriasis in the IMQ‐induced psoriasis‐like mouse model. Additionally, we confirmed that in vitro DMSCs‐derived EDIL3 is involved in the tube formation of ECs via αvβ3‐FAK/MEK/ERK signal pathway. This suggested that DMSCs‐derived EDIL3 and αvβ3‐FAK/MEK/ERK signal pathway in ECs play an important role in the pathogenesis of psoriasis. And the modification of DMSCs, EDIL3 and αvβ3‐FAK/MEK/ERK signal pathway will provide a valuable therapeutic target to control the angiogenesis in psoriasis.
Risk factors for tooth loss and progression of periodontitis in patients undergoing periodontal maintenance therapy
Authors: Siow Dawn S. F. , Goh Edwin X. J. , Ong Marianne M. A. , Preshaw Philip M. 
Published: September 2022

AbstractAimThe aim of this study was to investigate patient‐ and tooth‐level factors that may predict tooth loss and periodontitis progression in patients who have undergone at least 5 years of periodontal maintenance.Materials and MethodsIn this retrospective cohort study, 135 patients were examined after active periodontal therapy (APT) and periodontal maintenance for 5.09–8.65 years (mean 6.16 ± 0.74 years). Regression models were applied to identify risk factors associated with tooth loss and disease progression.ResultsStage IV periodontitis (incidence rate ratio [IRR] = 4.61; 95% confidence interval, CI [2.97–7.18], p < .001), the presence of ≥5 sites with probing pocket depth (PPD) ≥5 mm at the end of APT (IRR = 2.04; 95% CI [1.32–3.20], p < .01), and residual PPD ≥7 mm at the end of APT (odds ratio [OR] = 3.01; 95% CI [1.14–7.94], p < .05) were risk factors for tooth loss. Residual PPDs of 5 mm (OR = 2.02; 95% CI [1.20–3.40], p < .01) and 6 mm (OR = 2.41; 95% CI [1.22–4.76], p < .05) at the end of APT were risk factors for disease progression. Above 3 mm, each 1 mm increase in maximum PPD/clinical attachment loss was associated with an increased risk of tooth loss and disease progression.ConclusionsStage IV periodontitis is associated with an increased risk of tooth loss. Teeth with PPD ≥5 mm at the end of APT are at risk of periodontitis progression or tooth loss.
Changing spectrum of hair and scalp disorders over the last decade in a tertiary medical centre
Authors: Lyakhovitsky Anna , Tzanani Ido , Gilboa Sarit , Segal Oz , Galili Eran , Baum Sharon , Barzilai Aviv 
Published: September 2022

AbstractBackgroundHair‐ and scalp‐related disorders (HSRDs) encompass a wide range of conditions that affect people of all ages.ObjectiveTo evaluate the workload and trends in HSRDs at an outpatient dermatological clinic in a tertiary medical centre over a 10‐year period.MethodsMedical records for HSRD visits to the outpatient dermatology clinic at the Sheba Medical Center, an Israeli tertiary care center, were reviewed between 1 January, 2010 and 31 December, 2020.ResultsThere were 10,396 HSRD visits with a new‐to‐follow‐up visit ratio of 1:1.9. The annual number of HSRD visits, as well as their proportion out of all dermatological outpatient visits, have increased from 295 (1.24%) in 2010 to 1726 (9.44%) in 2020. The patients' mean age was 35.3 years (women 39.5 years, men 28.8 years), age range 1–87 years. Over the decade, there was a growing predominance of women with an average female‐to‐male ratio of 2:1. The winter season accounted for 28.7% of annual visits, followed by the autumn (25.6%), summer (24.3%) and spring (21.4%). The most prevalent HSRDs included androgenetic alopecia (30.6%), alopecia areata (19.3%), telogen effluvium (15.4%), non‐scarring folliculitis (15.4%), seborrheic dermatitis (14.9%), lichen planopilaris (7.1%) and folliculitis decalvans (6.6%). Androgenetic alopecia demonstrated the highest increase over the decade examined (from 17% to 32%).ConclusionHSRDs account for a significant percentage of visits at a tertiary dermatology outpatient clinic. The number of HSRD visits has increased annually over the past decade. The recent advancement in diagnosis and treatment may account, at least in part, for the growing burden of HSRDs within dermatological ambulatory care.
Exploring unheard voices: Best practices in interviewing women prosumers in Indian subsistence contexts
Authors: Jagadale Sujit Raghunathrao , Krisjanous Jayne 
Published: September 2022

AbstractA growing body of literature is focused on subsistence markets and how marketing interventions can increase well‐being for those whose daily existence is a struggle to ensure access to necessities of life. To understand the lifeworld of those living at the subsistence level, interviews are favored as a data collection tool. This methodological paper examines interviewing in the subsistence context with a focus on women whose lived experiences are affected by the intersection of gender, power imbalance, and culture. The study context is India. Specifically, we draw upon data from three previous author‐conducted academic studies and conduct a reflective analysis that leads to a series of reflections and recommendations for the interview process. This paper calls for more work to be done in the area and raises the need for a new research paradigm rather than reliance on western‐oriented approaches that may not fit the context.
Comprehensive review of oral minoxidil in alopecia
Authors: Modha Jay D. , Pathania Yashdeep Singh 
Published: September 2022

AbstractBackgroundThere have been various treatment modalities available for alopecia in the form of topical and systemic with a variable response. The compliance of the patients is important in reaping results in alopecia. Minoxidil has come a long‐way finding its use from topical formulations to systemic at lower dose in different alopecia.ObjectiveThe objective of this article is to discuss various conditions in alopecia where oral minoxidil has found its role.MethodsA comprehensive literature search was performed relating to oral minoxidil role in various alopecia. Various clinical trials, case series, and case reports were searched on PubMed and Google Scholar. The references of available studies were also reviewed to collect the additional resources. Available data from various studies and case reports were collected and consolidated to provide a concise overview of oral minoxidil indications in various alopecia.ResultsOral minoxidil has been used in various non‐scarring and scarring alopecia at a lower dosage with less side effects and with promising results. Androgenetic alopecia and female pattern hair loss were the two conditions where it has been used more commonly than other alopecia, providing a ray of hope along with overcoming the issues related to topical formulations and compliance.
Diversity trends in the leadership of the American Society for Laser Medicine And Surgery, 1996–2021
Authors: Chen Jennifer C. , Geronemus Roy G. , Feng Hao 
Published: September 2022

AbstractObjectivesTo evaluate the temporal trends in diversity within the ASLMS board of directions from 1996 to 2021.Materials and MethodsA list of Board of Directors from 1996 to 2021 was obtained from ASLMS headquarters. Using a composite of publicly available resources through internet searches, board director characteristics, such as age, gender, race/ethnicity, terminal degrees, specialties/field of expertise, and current full‐time affiliations, were recorded.ResultsOne hundred forty‐six unique individuals held 628 ALSMS board member positions from the years 1996‐2021. The median age of the board members started with a median age of 43.0 years old in 1996 to 54.5 years old in 2021. The age spread between first and third quartiles (interquartile range) in each year in more recent years (2014‐2019) was 17.0, 20.0, 18.8, 18.8, 18.0, and 15.3 years, respectively. Female representation started with 10.5% in 1996 to 30.8% in 2021. Diversity, by racial/ethnicity measures, has more representation of Asian (average across 1996‐2010: 2.3% to 2010‐2022: 19.0%) and Hispanic (average 1996‐2010: 0.7% to 2010‐2022: 4.4%) board members. No African American has held a position across these decades. MD holders (average 66.5%) and other degree holders (average 33.5%) have been relatively consistent across all years observed. From 2016 to 2021, dermatologists held board member seats at an average rate of 56.5% across these years, while prior, from 1996 to 2015, 67.3% of board member seats on average were held by members of other expertises. Most board members have full‐time affiliations in private practice across most years observed (average 43.7% across all years observed).ConclusionAfter analyzing the diversity trends across board members in ASLMS across 1996‐2020, we have noticed overall trends of increased diversity over time that reflect a greater chance of bringing in new ideas and experiences to grow ASLMS. Although the leadership of ASLMS has become significantly more diverse over time, there remain opportunities to increase diversity further, including women, underrepresented ethnic minorities, and other experts of specialties other than dermatology.
Navigating asthma—the immigrant child in a tug‐of‐war: A constructivist grounded theory
Authors: Sudarsan Indu , Hoare Karen , Sheridan Nicolette , Roberts Jennifer 
Published: September 2022

AbstractBackgroundAvoidable hospitalisation rates for Indian immigrant children with asthma is high in New Zealand and other Western countries. Understanding how children and their carers manage asthma may lead to a reduction in hospitalisation rates. The topic of asthma and Indian immigrant children's perspectives has not been investigated. Most studies on the topic focus on the experiences of family carers and health professionals. Practice cannot be advanced in the child's best interests unless the child's asthma experiences are explored. The following research addressed this gap by upholding Article 12 of the United Nations Convention on the Rights of the Child, thereby giving Indian immigrant children a voice in describing their asthma experiences.DesignConstructivist grounded theory.MethodsIntensive interviews were conducted with ten family carers and nine children (eight to 17 years old). Child‐sensitive data collection techniques such as drawing, and photography were used to facilitate interviewing children younger than 14 years. The COREQ guidelines guided the reporting of this study.ResultsThe theory, navigating asthma: the immigrant child in a tug‐of‐war, is the resulting grounded theory with the tug‐of‐war being the basic social process. This theory comprises three main categories: being fearful, seeking support and clashing cultures. The data reflected two types of tug‐of‐war: one between two cultures, the native Indian and the host New Zealand culture and another between family carers' and children's preferences.ConclusionAcculturation and sociocultural factors may significantly influence the asthma experiences of Indian immigrants.Relevance to clinical practiceThe theory may assist healthcare practitioners to better comprehend Indian immigrants' asthma experiences within their wider sociocultural context. Our research indicates the need for healthcare practitioners to work in partnership with Indian immigrant families to implement culturally safe asthma management strategies.
Female sexual function after repair of uterovaginal prolapse
Authors: Hamdy Mostafa A. , Ahmed Waleed A. S. , Abolill Zakia M. , Elshahat Amal M. , Taha Omima T. 
Published: September 2022

AbstractObjectiveTo evaluate the impact of repair of uterovaginal prolapse using sacrospinous hysteropexy on female sexual function.MethodsA cross‐sectional study was conducted at the Urogynecology Clinic of the Suez Canal University Hospital from May 2014 to April 2019. Twenty‐seven women with a diagnosis of uterovaginal prolapse and wishing to preserve their uteri were recruited. Sacrospinous ligament fixation was done. Sexual symptoms were assessed using the female sexual function index (FSFI) questionnaire just before and 6 months after the operation.ResultsThe mean age of the participants was 36.5 ± 4 years. Sacrospinous hysteropexy only was performed for three women. Additional procedures included anterior colporrhaphy (12), posterior colporrhaphy (9), and perineorrhaphy (15). There was a significant improvement in pre‐ and postoperative patients' orgasm (3.1 ± [0.8] vs. 3.7 ± [1.1]; p value = 0.03) and satisfaction (3.4 ± [0.6] vs. 4.2 ± [0.8]; p value < 0.001) while there was worsening of pain (4.3 ± [1.5] vs. 3.2 ± [1.6]; p value = 0.017). There was insignificant improvement in the other three domains as well as total score of FSFI, with all patients having sexual dysfunction.ConclusionSacrospinous hysteropexy was associated with significant improvement orgasm and satisfaction domains of FSFI and significant worsening of pain.
Evaluation of the fracture resistance and failure types of different CAD‐CAM ceramic crowns supported by angled titanium abutments
Authors: Yüksel Merve , Saygin Ayşegül Göze , Bolayir Giray 
Published: September 2022

AbstractPurposeTo evaluate the fatigue resistance of computer‐aided design and computer‐aided manufacturing (CAD‐CAM) single‐ceramic crowns which were applied on angled implant abutments after thermomechanical aging.Materials and MethodsTitanium abutments (N = 72, MODE Medical Dental Implant, Turkey) with three different angles (0˚, 15°, and 25°) were restored using different materials (monolithic zirconia [Zir], lithium silicate ceramic reinforced by zirconia [VS], and hybrid ceramic [VE]). Crowns in the maxillary first premolar form were cemented to abutments using resin cement (Panavia 2.0 Introkit). Dynamic loading and thermomechanical aging were applied to the specimens (120,000 cycles, 49 N, 5‐55°C). Fracture resistance values were measured in the universal test machine and fracture types were determined. Two‐way ANOVA and Tukey test were used for statistical analysis (Jamovi version 2.3.5).ResultsBoth the abutment angle and the type of material had a significant effect on fracture resistance (F = 3.295, p < 0.05). The highest fracture resistance was obtained in Group 0˚‐Zir, and the lowest fracture resistance was obtained in Group 15˚‐VE. Fracture resistance showed significant differences between Group 0˚ and Group 15˚ for the Zir and VE materials, and between Group 0˚ and Group 25˚ for VS (p < 0.05); no statistical significance was determined between the other groups (p>0.05). When failure types were evaluated, they were seen to be full or partial crown fractures, and abutment deformation was found in some samples.ConclusionsMonolithic crowns may be preferred on angled abutments. The fracture resistance of CAD‐CAM materials decreases as the angle of abutments increases. Monolithic zirconia has higher fracture resistance than other materials.
Effects of applying nutritional programming at different early stages of Largemouth bass (Micropterus salmoides, Lacepède) development on growth and dietary plant protein utilization
Authors: Schwepe Connor , Wojno Michal , Molinari Giovanni S. , Kwasek Karolina 
Published: September 2022

AbstractPlant protein (PP) utilization in fish is limited due to lower digestibility compared to fishmeal (FM) and the presence of antinutritional factors. Its utilization can be improved by nutritional programming (NP), a method wherein a fish is provided a nutritional stimulus early in life which can alter their physiology. NP has been shown to be effective but methods of applying NP are varied and have been applied at different stages of development with different outcomes. To find the optimal timeframe to perform NP in fish early stages Largemouth bass (Micropterus salmoides, Lacepède) were nutritionally programmed at three different ages in early development. In this study bass were programmed with: (1) live food enriched with soybean meal (SBM) from 6 to 15 days post‐hatch (dph) (NPL), (2) SBM‐based formulated diet from 16 to 25 dph (NPD1) and (3) formulated SBM‐diet from 26 to 35 dph (NPD2). After programming, each group was fed FM‐diet before being refed SBM‐diet from 100 to 172 dph. A positive control (PC) was fed FM‐diet throughout. Final average body weight of PC was significantly higher than NPD1 and NPD2 but did not significantly differ from NPL. Overall NPL showed much improved growth and utilization of PP compared to NPD1 and was similar to growth achieved by PC. This study showed an optimum window of time exists wherein NP of Largemouth bass yields the best impact on growth in the larval stage and later in life when fed SBM‐diet. Programming should be performed right after mouth opening using enriched live food and can result in growth similar to non‐programmed fish fed FM‐based diet. Programming effects similar to that of the live food approach can be achieved with formulated diet, however it is crucial that Largemouth bass are of a proper age and sufficiently developed when programmed with dry food or severe impacts on growth can occur.
The Good Sleeper Scale‐15 items: a questionnaire for the standardised assessment of good sleepers
Authors: Manners Jack , Appleton Sarah L. , Reynolds Amy C. , Melaku Yohannes Adama , Gill Tiffany K. , Lovato Nicole , Sweetman Alexander , Bickley Kelsey , Adams Robert , Lack Leon , Scott Hannah 
Published: September 2022

SummaryResearch with ‘good sleepers’ is ubiquitous, yet there are no standardised criteria to identify a ‘good sleeper’. The present study aimed to create and validate a questionnaire for identifying good sleepers for use in research studies known as the Good Sleeper Scale‐15 items (GSS‐15). Data were derived from a population‐based survey of Australian adults (n = 2,044). A total of 23 items were chosen for possible inclusion. An exploratory factor analysis (EFA) was conducted on ~10% of the survey dataset (n = 191) for factor identification and item reduction. A confirmatory factor analysis (CFA) was conducted on the remaining data (n = 1,853) to test model fit. Receiver operating characteristic curves and correlations were conducted to derive cut‐off scores and test associations with sleep, daytime functioning, health, and quality‐of‐life. The EFA identified six factors: ‘Sleep Difficulties’, ‘Timing’, ‘Duration’, ‘Regularity’, ‘Adequacy’, and ‘Perceived Sleep Problem’. The CFA showed that model fit was high and comparable to other sleep instruments, χ2 (63) = 378.22, p < 0.001, root mean square error of approximation = 0.05, with acceptable internal consistency (α = 0.76). Strong correlations were consistently found between GSS‐15 global scores and outcomes, including ‘a good night′s sleep’ (r = 0.7), ‘feeling un‐refreshed’ (r = −0.59), and ‘experienced sleepiness’ (r = −0.51), p < 0.001. Cut‐off scores were derived to categorise individuals likely to be a good sleeper (GSS‐15 score ≥40) and those very likely to be a good sleeper (GSS‐15 score ≥45). The GSS‐15 is a freely available, robust questionnaire that will assist in identifying good sleepers for the purpose of sleep research. Future work will test relationships with other sleep measures in community and clinical samples.
Collective and harmonized high throughput barcoding of insular arthropod biodiversity: Toward a Genomic Observatories Network for islands
Authors: Emerson Brent C. , Borges Paulo A. V. , Cardoso Pedro , Convey Peter , deWaard Jeremy R. , Economo Evan P. , Gillespie Rosemary G. , Kennedy Susan , Krehenwinkel Henrik , Meier Rudolf , Roderick George K. , Strasberg Dominique , Thébaud Christophe , Traveset Anna , Creedy Thomas J. , Meramveliotakis Emmanouil , Noguerales Víctor , Overcast Isaac , Morlon Hélène , Papadopoulou Anna , Vogler Alfried P. , Arribas Paula , Andújar Carmelo 
Published: September 2022

AbstractCurrent understanding of ecological and evolutionary processes underlying island biodiversity is heavily shaped by empirical data from plants and birds, although arthropods comprise the overwhelming majority of known animal species, and as such can provide key insights into processes governing biodiversity. Novel high throughput sequencing (HTS) approaches are now emerging as powerful tools to overcome limitations in the availability of arthropod biodiversity data, and hence provide insights into these processes. Here, we explored how these tools might be most effectively exploited for comprehensive and comparable inventory and monitoring of insular arthropod biodiversity. We first reviewed the strengths, limitations and potential synergies among existing approaches of high throughput barcode sequencing. We considered how this could be complemented with deep learning approaches applied to image analysis to study arthropod biodiversity. We then explored how these approaches could be implemented within the framework of an island Genomic Observatories Network (iGON) for the advancement of fundamental and applied understanding of island biodiversity. To this end, we identified seven island biology themes at the interface of ecology, evolution and conservation biology, within which collective and harmonized efforts in HTS arthropod inventory could yield significant advances in island biodiversity research.
A case of peripheral‐type facial palsy with dysgeusia due to pontine infarction: A case report
Authors: Fukunaga Daiki , Jun Fujinami , Toru Kishitani , Naoki Tokuda , Soichiro Numa , Nagakane Yoshinari 
Published: September 2022

AbstractWe describe an 83‐year‐old woman who presented with an acute onset of hemifacial droop. The patient's neurological examination showed peripheral‐type facial palsy with dysgeusia of the right anterior two‐thirds of her tongue. However, MRI revealed an anterior inferior cerebellar artery lesion, diagnosed as brain stem infarction. Peripheral‐type facial palsy has been reported in some stroke cases, with these cases not presenting with dysgeusia. Thus, this finding usually helps differentiate facial nerve palsy from peripheral‐type facial palsy caused by brain stem lesions. Despite the cerebral infarction, our patient presented with peripheral facial nerve palsy with taste disorder. This is because the lesion not only involved the pons but also the middle cerebellar peduncle. Therefore, patients with multiple vascular risk factors need to be carefully diagnosed.