bluuebunny/crossref_metadata_2025_split huggingface dataset:
SIRT7 is a prognostic biomarker in kidney renal clear cell carcinoma that is correlated with immune cell infiltration
Authors: Zhang Wei , Qian Yue , Jin Xue , Wang Yixian , Mu Lili 
Published: January 2022

Abstract
Background: SIRT7 has been shown to be expressed in many cancer types, including kidney renal clear cell carcinoma (KIRC), but its functional role in this oncogenic context remains to be firmly defined. This study was designed to explore correlations between SIRT7 and KIRC characteristics using the TCGA database. Methods: Relationships between SIRT7 expression and KIRC patient clinicopathological characteristics were assessed through Kruskal-Wallis tests, Wilcoxon signed-rank tests, and logistic regression analyses. Area under the ROC curve (AUC) values were used to assess the prognostic value of SIRT7 as a means of classifying KIRC patients. The functional role of SIRT7 in this cancer type was assessed through GO/KEGG enrichment analyses and immune cell infiltration analyses. Results: In KIRC patients, higher levels of SIRT7 expression were associated with Race, M stage, T stage (all P < 0.05). SIRT7 offered significant diagnostic value in ROC curve analyses (AUC = 0.912), and elevated SIRT7 levels were linked to worse patient overall survival (OS; P < 0.001). The expression of SIRT7 was independently related with KIRC patient OS (HR: 1.827; 95%CI: 1.346-2.481; P<0.001). In GO/KEGG analyses, SIRT7 was found to be associated with ubiquitin-mediated proteolysis and nucleotide excision repair. Higher SIRT7 expression was related to the enhanced infiltration of certain immune cells.Conclusions: Increased SIRT7 expression was associated with a worse KIRC patient prognosis, and immune infiltrates, suggesting it may offer value as a prognostic biomarker for this cancer type.
Color effects of Cu nanoparticles in Cu-bearing plagioclase feldspars
Authors: Jin Shiyun , Sun Ziyin , Palke Aaron C. 
Published: January 2022

Abstract
The optical properties (scattering, absorption, and extinction) of spheroidal Cu particles embedded in intermediate plagioclase feldspar are computed for various sizes and shapes using the Mie theory and T-matrix method. The observed color for Cu-bearing plagioclase, as a function of particle size and shape, is also calculated from the computed extinction spectra. The colors and pleochroism observed in natural and treated Cu-bearing plagioclase can be explained from the computational results. The enigmatic green colors in some precious Oregon sunstones result from red light being scattered away by Cu nanoparticles of certain sizes. The UV-VIS spectra are collected on Cu-bearing plagioclase samples for comparison with the computational results, which are shown to match the optical observations. The results from this work may be used to quantify the concentration of colloidal Cu in plagioclase or glass with a similar refractive index. Particle sizes and shapes can also be characterized using extinction and scattering spectra, which can be collected with different optical configurations. New materials with special color effects and optical characteristics may be designed and engineered by applying the unusual properties of metal colloids.
Determination of Both TP53 Mutation Status and the Amount of p53
Protein has Limited Diagnostic Importance for Patients with Ovarian
Cancer
Authors: Klein Sebastian M. , Bozko Maria , Toennießen Astrid , Malek Nisar P. , Bozko Przemyslaw 
Published: January 2022

Background:
Ovarian cancer is one of the most aggressive types of gynecologic cancers. Many patients have a relapse within two years after diagnosis and subsequent therapy. Among different genetic changes generally believed to be important for the development of cancer, TP53 is the most common mutation in the case of ovarian tumors.

Objective:
Our work aims to compare the outcomes of different comparisons based on the overall survival of ovarian cancer patients, determination of TP53 status, and amount of p53 protein in tumor tissues.

Methods:
We analyzed and compared a collective of 436 ovarian patient’s data. Extracted data include TP53 mutation status, p53 protein level, and information on the overall survival. Values for p53 protein level in dependence of TP53 mutation status were compared using the Independent-Samples t-Test. Survival analyses were displayed by Kaplan-Meier plots, using the log-rank test to check for statistical significance.

Results:
We have not found any statistically significant correlations between determination of TP53 status, amount of p53 protein in tumor tissues, and overall survival of ovarian cancer patients.

Conclusion:
In ovarian tumors both determination of TP53 status as well as p53 protein amount has only limited diagnostic importance.
Recent Advances in Dimethyl Sulfoxide (DMSO) Used as a Multipurpose Reactant
Authors: Cai Su-Qian , Zhang Ke-Feng , Cai Xiao-Hua 
Published: January 2022

Abstract:
Dimethyl sulfoxide (DMSO) is not only a common and cheap aprotic polar solvent
with low toxicity but also serves as an efficient and multipurpose reactant, and has widely
been used in organic synthesis. DMSO as an important precursor can effectively introduce a
broad range of functional fragments into organic molecules, such as -Me, -CH, -CH2, -SMe2, -
CH2SMe, -CH2SOMe, -SMe, -SO2Me, -SOMe or O substituents, and serves as a mild oxidant
in organic transformations. Many significant achievements based on DMSO as a synthon in
synthetic chemistry have rapidly been made over the past several years. To help researchers
further understand the recent advances in the field, the review summarizes the applications of
DMSO as carbon, sulfur, and oxygen sources and its use as the dual synthon in synthetic
transformations.
Aptamers Against COVID-19: An Untested Opportunity
Authors: Haberland Annekathrin , Müller Johannes 
Published: January 2022

Abstract:
Given the lack of success in the development of effective drugs to treat COVID-19, which show “game-changing” potential, it is necessary to explore drugs with different modes of action. Single mode-of-action drugs have not been succeeded in curing COVID-19, which is a highly complex disease. This is the case for direct antivirals and anti-inflammatory drugs, both of which treat different phases of the disease. Aptamers are molecules that deliver different modes of action, allowing their effects to be bundled, which, when combined, support their therapeutic efficacy. In this minireview, we summarise the current activities in the development of aptamers for the treatment of COVID-19 and long-COVID. A special emphasis is placed on the capability of their multiple modes of action, which is a promising approach for treating complex diseases such as COVID-19.
Development of an Insulin Nano-delivery System through Buccal Administration
Authors: Bozeya Ayat , Al-Domi Diaa , Al-Fandi Mohamed 
Published: January 2022

Aim:
The aim of the study was to develop a new nano-delivery system for buccal administration
of insulin.

Background:
Biodegradable polymeric nanoparticles (PNPs) had undergone countless breakthroughs
in drug delivery systems. The main objective of PNPs application in delivering and carrying
different promising drugs is to make sure that the drugs are being delivered to their action sites,
maximizing the desired effect and overcoming their limitations and drawbacks.

Objectives:
The main goals of this study were to produce an insulin consumable nano-delivery system
for buccal administration and enhance the mucoadhesive effect in sustaining insulin release.

Methods:
Water-oil-water (W-O-W) microemulsion solvent evaporation technique was used for
the preparation of nanoparticles consisting of positively charged poly (D, L-lactide-co-glycolide)
coated with chitosan and loaded with insulin. Later, a consumable buccal film was prepared by the
spin coating method and loaded with the previously prepared nanoparticles.

Results:
The newly prepared nanoparticle was assessed in terms of size, charge and surface morphology
using a Scanning Electron Microscope (SEM), zeta potential, Atomic Force Microscope
(AFM), and Fourier Transform Infra-red (FTIR) spectroscopy. An in-vitro investigation of the insulin
release from nanoparticles and buccal film demonstrated controlled as well as sustained delivery
over 6 hrs. The cumulative insulin release decreased to about 28.9% with buccal film compared
to the nanoparticle (50%).

Conclusion:
The buccal film acted as a barrier for insulin release. Therefore, the release was sustained.
Green and Efficient Synthesis of 1, 2, 4-Triazolidine-3-thiones using
Guanidine Hydrochloride as a Recyclable Catalyst under the Aqueous
Condition
Authors: Barkule Angad B. , Gadkari Yatin U. , Telvekar Vikas N. 
Published: January 2022

Abstract:
A rapid and highly efficient methodology for the synthesis of 1, 2, 4-triazolidine-3-thiones
derivatives has been developed in the presence of a catalytic amount of guanidine hydrochloride using
water as a solvent. The reaction of thiosemicarbazide with different aryl aldehydes resulted in the formation
of title compounds in good yields (85-95%) with a convenient reaction time (20-30 min). The
key advantages of this approach include shorter reaction time, energy efficiency, easy work-up procedure,
and wide substrate scope tolerance. Furthermore, the catalyst was recycled without significant
loss of its catalytic activity.
Genitourinary Tract Tumors in Children: An Update
Authors: García-Perdomo Herney Andrés , González-Arboleda Andrés Augusto , Fernandez Nicolás 
Published: January 2022

Background:
Genitourinary tract tumors in children are less common than in adults.
Most of these tumors have different genetic backgrounds, clinical presentation, and oncologic behavior
than their adult counterpart. As a result of low prevalence in children, some of the treatment
approaches and recommendations are based on treatment experience in adult patients. However,
thanks to scientific and technological development, survival rates have risen considerably.

Objective:
This paper presents a review of the principal features of the tumors involving the genitourinary
tract in children and an update in genetic background, diagnosis, and treatment.

Methods:
A narrative review was performed on published literature about genitourinary tract tumors
in pediatric patients. Papers presented in English and Spanish literature were reviewed.
PubMed, Science Direct, and SciELO databases were used to collect information and present this
article.

Results:
Kidney tumors are the most common type of genitourinary tumors in children. Among
those, Wilms tumor represents the majority of cases and shows the successful work of clinical trial
groups studying this tumor type. Other tumors involving the genitourinary tract in children include
Rhabdomyosarcoma, Transitional cell carcinoma, Testicular, and Adrenal tumors.

Conclusion:
Genitourinary tract tumors in children represent significant morbidity and economic
burden, so awareness in early diagnosis represents improvement in treatment, clinical, and oncological
outcomes.
Impact of the COVID-19 Pandemic on Chronic Neurological Disorders: Focus on Patients with Dementia
Authors: Irrera Natasha , Barbieri Maria Antonietta , Bagnato Gianluca , Ioppolo Carmelo , Versace Antonio Giovanni 
Published: January 2022

Abstract:The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) represents a public health problem worldwide. COVID-19 triggers a maladaptive cytokine release commonly referred to as cytokine storm syndrome with increased production of proinflammatory cytokines, which also appears to contribute to chronic neuroinflammation and neurodegenerative disorders’ appearance, including multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. In this context, SARS-CoV-2 might enter the central nervous system through binding with the angiotensin converting enzyme 2 receptors which are highly expressed in glial cells and neurons. For this reason, an association between COVID-19, its dependent cytokine storm, and the development and/or progression of neurodegenerative disorders might be evaluated. Therefore, the aim of this review was to assess the impact of COVID-19 on neurodegenerative disorders, focusing on the possible increased mortality risk and/or deterioration of the clinical course of pre-existing chronic neurological diseases in patients with dementia.
DFT Studies and Quantum Chemical Calculations of Benzoyl
Thiourea Derivatives Linked to Morpholine and Piperidine for the
Evaluation of Antifungal Activity
Authors: Tigote Radhakrishnan M. , Dongare Rameshwar K. , Inamdar Shaukatali N. 
Published: January 2022

Background:
Benzoyl thiourea derivatives linked to morpholine and piperidine
have been reported to possess good antifungal activity.

Objective:
The aim of the study was to find the correlations between the quantum chemical
calculations and the antifungal activity of the benzoyl thiourea derivatives linked to morpholine
and piperidine.

Methods:
Optimization of six compounds BTP 1-3 and BTM 4-6 was carried out with DFT
using B3LYP method utilizing 6-31G(d,p) basis set. The structural parameters of the compounds
as molecular geometry, bond lengths, bond angles, atomic charges and HOMOLUMO
energy gap have been investigated and compared with the reported experimental results.

Results:
A good correlation between the quantum chemical calculations and the antifungal
activity of the benzoyl thiourea derivatives linked to morpholine and piperidine was found.

Conclusion:
The DFT study of benzoyl thiourea derivatives linked to morpholine and piperidine
conducted with respect to their Quantum chemical parameters for evaluation of
their antifungal activity showed good correlations between the antifungal activity and the
quantum chemical parameters.
Polymer Supported Proline-Based Organocatalysts in Asymmetric Aldol
Reactions: A Review
Authors: Saithalavi Anas , Shajahan Rubina , Sarang Rithwik 
Published: January 2022

Abstract:
The use of proline-based organocatalysts has acquired significant attention in organic
synthesis, especially in enantioselective synthesis. Proline and its derivatives are proven to be quite
effective chiral organocatalysts for a variety of transformations, including the aldol reaction, which
is considered as one of the important C-C bond forming reactions in organic synthesis. The use of
chiral organocatalysts has several advantages over its metal-mediated analogues. Subsequently, a
large number of highly efficient proline-based organocatalysts, including polymer-supported chiral
analogues, have been identified for aldol reaction. The use of polymer-supported organocatalysts
exhibited remarkable stability under the reaction conditions and offered the best results, particularly
in terms of its recyclability and reusability. These potential benefits along with their economic
and green chemistry advantages have led to the search for many polymer-supported proline catalysts.
In this review, recent developments in exploring various polymer immobilized proline-
based chiral organocatalysts for asymmetric aldol reactions are described.
COVID-19 Assessment and Testing in Rural Communities During the Pandemic: Cross-sectional Analysis
Authors: Fitzsimon Jonathan , Gervais Oliver , Lanos Chelsea 
Published: January 2022

Background
The COVID-19 pandemic exacerbated the need for urgent improvements in access to health care for rural, remote, and underserviced communities. The Renfrew County Virtual Triage and Assessment Centre (VTAC) was designed to provide access to COVID-19 testing and assessment with a family physician. The goal was to protect emergency departments and 911 paramedics while ensuring that nobody was left at home, suffering in silence. Residents were encouraged to call their own family physician for any urgent health needs. If they did not have a family physician or could not access their usual primary care provider, then they could call VTAC. This study reports on the output of a service model offering access to assessment and COVID-19 testing through a blend of virtual and in-person care options by a multidisciplinary team.

Objective
The purpose of this study was to assess the ability of VTAC to provide access to COVID-19 assessment and testing across rural, remote, and underserviced communities.

Methods
We conducted a cross-sectional analysis of the data derived from the cases handled by VTAC between March 27, 2020 (launch day), and September 30, 2020.

Results
Residents from all 19 census subdivisions and municipalities of Renfrew County accessed VTAC. A total of 10,086 family physician assessments were completed (average 64 per day). Of these, 8535 (84.6%) assessments were to unique patient users. Thirty physicians provided care. Using digital equipment setup in the patients’ home, 31 patients were monitored remotely. VTAC community paramedics completed 14,378 COVID-19 tests and 3875 home visits.

Conclusions
Renfrew County’s experience suggests that there is tremendous synergy between family physicians and community paramedics in providing access to COVID-19 assessment and COVID-19 testing. The blended model of virtual and in-person care is well suited to provide improved access to other aspects of health care post pandemic, particularly for patients without a family physician.
A Tailored App for the Self-management of Musculoskeletal Conditions: Evidencing a Logic Model of Behavior Change
Authors: Berry Alice , McClellan Carey , Wanless Ben , Walsh Nicola 
Published: January 2022

Background
Musculoskeletal conditions such as joint pain are a growing problem, affecting 18.8 million people in the United Kingdom. Digital health interventions (DHIs) are a potentially effective way of delivering information and supporting self-management. It is vital that the development of such interventions is transparent and can illustrate how individual components work, how they link back to the theoretical constructs they are attempting to change, and how this might influence outcomes. getUBetter is a DHI developed to address the lack of personalized, supported self-management tools available to patients with musculoskeletal conditions by providing knowledge, skills, and confidence to navigate through a self-management journey.

Objective
The aim of this study was to map a logic model of behavior change for getUBetter to illustrate how the content and functionality of the DHI are aligned with recognized behavioral theory, effective behavior change techniques, and clinical guidelines.

Methods
A range of behavior change models and frameworks were used, including the behavior change wheel and persuasive systems design framework, to map the logic model of behavior change underpinning getUBetter. The three main stages included understanding the behavior the intervention is attempting to change, identifying which elements of the intervention might bring about the desired change in behavior, and describing intervention content and how this can be optimally implemented.

Results
The content was mapped to 25 behavior change techniques, including information about health consequences, instruction on how to perform a behavior, reducing negative emotions, and verbal persuasion about capability. Mapping to the persuasive system design framework illustrated the use of a number of persuasive design principles, including tailoring, personalization, simulation, and reminders.

Conclusions
This process enabled the proposed mechanisms of action and theoretical foundations of getUBetter to be comprehensively described, highlighting the key techniques used to support patients to self-manage their condition. These findings provide guidance for the ongoing evaluation of the effectiveness (including quality of engagement) of the intervention and highlight areas that might be strengthened in future iterations.
The Behavior Change Techniques Used in Canadian Online Smoking Cessation Programs: Content Analysis
Authors: Struik Laura , Rodberg Danielle , Sharma Ramona H 
Published: January 2022

Background
Smoking rates in Canada remain unacceptably high, and cessation rates have stalled in recent years. Online cessation programs, touted for their ability to reach many different populations anytime, have shown promise in their efficacy. The Government of Canada has therefore funded provincial and national smoking cessation websites countrywide. However, little is known about the behavior change techniques (BCTs) that underpin the content of these websites, which is key to establishing the quality of the websites, as well as a way forward for evaluation.

Objective
The purpose of this study, therefore, is to apply the BCTTv1 taxonomy to Canadian provincial and federal websites, and to determine which BCTs they use.

Methods
A total of 12 government-funded websites across Canada were included for analysis. Using deductive content analysis and through training in applying the BCTTv1 taxonomy, the website content was coded according to the 93 BCTs across the 16 BCT categories.

Results
Of the 16 BCT categories, 14 were present within the websites. The most widely represented BCT categories (used in all 12 websites) included goals and planning, social support, natural consequences, and regulation. Implementation of BCTs within these categories varied across the sites.

Conclusions
Analyzing the content of online smoking cessation websites using the BCTTv1 taxonomy is an appropriate method for identifying the behavior change content of these programs. The findings offer programmers and researchers tangible directions for prioritizing and enhancing provincial and national smoking cessation programs, and an evaluation framework to assess smoking cessation outcomes in relation to the web-based content.
The Engineering Characteristics and Classifications of Rock Masses along Road Section from Prambanan to Patuk, Yogyakarta, Indonesia
Authors: Juhari Aisyah Shahirah , Indrawan, Dr. I Gde Budi , Wilopo Wahyu 
Published: January 2022

Several attraction places and agriculture area that essentials for tourism and villager to do their activities are located approximately 6 km along the road of Candi Ijo to Ngoro-Oro in between Prambanan and Patuk sub-districts, Yogyakarta, Indonesia. Many jointed rock masses along the road have the potential to fail. This paper describes the rock mass characteristic and quality determined using the Geological Strength Index (GSI) and Rock Mass Rating (RMR) classifications. The rock mass characteristic and quality were essentially the preliminary results of a study to evaluate stability of the rock slopes along the road of Candi Ijo to Ngoro-Oro. Field observation and laboratory tests were carried out to determine parameters of the GSI and RMR. The results show that the slopes in the study area consisted of tuffaceous sandstone, vitric tuff, lithic tuff, cemented tuffaceous sandstone, lapilli tuff, subarkose, laminated mudrock, and laminated tuffaceous sandstone. The intact rocks were classified as weak to very strong. The research area consisted of three rock mass qualities, namely fair rock mass quality having GSI between 30 and 45 and RMR between 41 and 60, good rock mass quality having GSI between 46 to 65 and RMR between 61 and 80, and very good rock mass quality having GSI > 65 and RMR between 81-100. The relationship between GSI and RMR obtained in this study was in good agreement with that proposed by Hoek et al. (1995).