bluuebunny/crossref_metadata_2025_split huggingface dataset:
Durable Immunity to Ricin Toxin Elicited by Intranasally Administered Monoclonal Antibody–Based Immune Complexes
Authors: Tolman Lindsey E , Yates Jennifer L , Rong Yinghui , Reynolds-Peterson Claire , Ehrbar Dylan , Torres-Velez Fernando J , Mantis Nicholas J 
Published: June 2022

Abstract
Inhalation of ricin toxin (RT) elicits profuse inflammation and cell death within the upper and lower airways, ultimately culminating in acute respiratory distress syndrome. We previously reported that the effects of pulmonary RT exposure in mice are nullified by intranasal administration of an mAb mixture consisting of PB10, directed against ricin’s enzymatic subunit (RTA), and SylH3, directed against ricin’s binding subunit (RTB). We now report that delivery of PB10 and SylH3 as an RT–mAb immune complex (RIC) to mice by the intranasal or i.p. routes stimulates the rapid onset of RT-specific serum IgG that persists for months. RIC administration also induced high-titer, toxin-neutralizing Abs. Moreover, RIC-treated mice were immune to a subsequent 5 × LD50 RT challenge on days 30 or 90. Intranasal RIC administration was more effective than i.p. delivery at rendering mice immune to intranasal RT exposure. Finally, we found that the onset of RT-specific serum IgG following RIC delivery was independent of FcγR engagement, as revealed through FcγR knockout mice and RICs generated with PB10/SylH3 LALA (leucine to alanine) derivatives. In conclusion, a single dose of RICs given intranasally to mice was sufficient to stimulate durable protective immunity to RT by an FcγR-independent pathway.
The Wave Function Collapse Algorithm and its Application to AI Navigation
Authors: Trefry Luke 
Published: June 2022

For so long, game developers have had to hand place waypoints, leading to linear paths being taken by Artificial Intelligence (AI) which move between them. These paths often loop, and if they don’t, they only serve to move an AI from point A to point B in the same way time and time again. A more dynamic solution is needed, and the Wave Function Collapse Algorithm is suited to provide that. This solution was implemented in the Unity engine using C#. By utilizing the provided Wave Function Collapse Algorithm template, waypoints were able to be substituted for game objects. When implemented in this manner, the Wave Function Collapse Algorithm places waypoints within a defined area allowing an AI navigator to maneuver between them. Should a waypoint be inaccessible, the waypoints will regenerate. Waypoints, upon the map regenerating, are removed so that any of those colliding waypoints cannot be accessed by the AI. This creates a dynamic path for an AI to traverse. The AI only moves between active waypoints and the map is able to regenerate so that the paths laid out do not succumb to the same pitfalls that traditionally plotted paths do. The next logical step is to apply the Wave Function Collapse Algorithm to a generated map. By allowing the Wave Function Collapse Algorithm to plot waypoints dynamically and continuously, different applications can utilize this to allow an AI to traverse a map in a unique way.
Instances of Human Genetic Resistance Against Pathogens
Authors: Sampson Joshua , Ravindran Pavithran 
Published: June 2022

This paper will review research on genetic mutations in humans that grant resistance against pathogens. It will describe the characteristics of these genetic traits, which pathogens they grant resistance to, and the mechanism by which these traits provide resistance. It will then discuss the detrimental aspects of these traits, if any, and the potential applications of the genetic resistance mechanisms. Finally, it will cover further research on the genetic trait or pathogen that should be conducted. The following traits will be discussed within this review: sickle cell mutation in the hemoglobin gene and malaria resistance, the Δ32 mutation in the CCR5 gene and HIV resistance, and the erythrocyte silent mutation in the Duffy antigen promoter and malaria resistance. The research conducted on these genetic traits has allowed us to understand more of the pathophysiology of the disease they resist against.
Effects of Health Care System Responsiveness On Diabetes Management Among the Patients Seeking Care at St. Mary’s Mission Hospital in Nairobi
Authors: Njiru Zipporah Wawira , Mulemi B.A. , Njeri S. Ngacha 
Published: June 2022

Purpose: Diabetes is one of the non-communicable diseases (NCDs) of great global public health and development concern. This NCD has adverse effects on the social well-being of patients, their households, and the whole society. The overall objective of this study was to determine the effects of health care system responsiveness on diabetes management among the patients seeking care at St. Mary’s Mission Hospital in Nairobi.
Methodology: This study drew on descriptive study design, involving quantitative and qualitative methods, particularly closed and open questions. The sample size was 269 respondents included in the study through purposive and convenient sampling. These sampling techniques were preferred in this research since data was gathered from the respondents during their visit to the hospital. The researcher collected data through interviewer-administered questionnaires containing both open and closed questions. Qualitative data was grouped, coded, and categorized, picking on cross-cutting issues, then compiled, analysed, and interpreted accordingly. Quantitative data was coded then entered into Statistical Package for Social Sciences (SPSS) version 22 for windows. SPSS was used to run frequency distributions and cross-tabulations for analysis and interpretation, and Microsoft Excel was used for graphical presentation.
Findings: The study established unequal distribution of health care facilities for diabetes management across the Counties in Kenya. This leads to a late diabetes diagnosis. The respondents reported that the health care system in Kenya does not offer an affordable quality of care to diabetes patients. This makes some patients skip days or weeks without medication.
Unique contribution to theory, practice and policy: The study recommends the hospitals to form support groups or devise other forums for patients’ education and encouragement on diabetes management. They should also look into the possibilities of having diabetes services in one building. This would ensure rapid diagnostic tests and treatment for diabetes patients.
Formation of the motivational and value component of the economic competence of future bachelors in the field of training "Physical Culture" with the use of digital technologies
Authors: Кручинина Г.А. , Сорокин И.А. 
Published: June 2022

Актуальность статьи обусловлена тем, что у выпускников образовательных организаций высшего образования должен быть сформирован определенный уровень экономической компетентности. Целью статьи является представление результатов исследований по оценке сформированности мотивационно-ценностного компонента экономической компетентности будущих бакалавров направления подготовки «Физическая культура» с применением цифровых технологий. На основе анализа психолого-педагогических научных источников было выявлено, что цифровые технологии являются эффективным средством формирования и развития компонентов экономической компетентности: мотивационно-ценностного, когнитивно-деятельностного, рефлексивно-оценочного. Нами был проведен эксперимент по оценке влияния применения средств цифровых технологий на формирование мотивационно-ценностного компонента экономической компетентности будущих бакалавров. В статье проводится анализ: динамики направленности мотивации будущих бакалавров; мотивов учебной деятельности; интереса к изучению экономических дисциплин и применения средств цифровых технологий при обучении. Статья предназначена для: исследователей в области формирования экономической компетентности, работников образовательных организаций высшего образования.
The relevance of the article is due to the fact that graduates higher educational institutions of higher education should have a certain level of economic competence. The purpose of the article is to present the results of studies on the evaluation of the formation of the motivational and value component of the economic competence of future bachelors in the field of training "Physical Culture" with the use of digital technologies. Based on the analysis of psychological and pedagogical scientific sources, it was revealed that digital technologies are an effective means of forming and developing components of economic competence: motivational-value, cognitive-activity, reflexive-evaluative. We conducted an experiment to assess the impact of the use of digital technologies on the formation of the motivational and value component of the economic competence of future bachelors. The article analyzes: dynamics of the orientation of motivation of future bachelors; motives of educational activity; interest in the study of economic disciplines and the use of digital technologies in teaching. The article is intended for: researchers in the field of economic competence formation, employees of higher educational institutions of higher education.
The role of higher educational institutions in the improvement of students: comparative analysis
Authors: Морозкина А.И. , Наумкин А.Н. , Наумкина Т.С. 
Published: June 2022

Актуальность статьи обусловлена противоречиями между потребностями студентов в оздоровлении и возможностью ее организации в современной высшей школе. Цель статьи заключается в сравнительном анализе деятельности вузов по оздоровлению студентов и формировании у них навыков здорового образа жизни. Автором определены основные направления деятельности вуза в сфере оздоровления студенческой молодежи, формировании у них навыков здорового образа жизни. Выделены общие и специфические составляющие социально-оздоровительной деятельности вузов. Подчеркнута зависимость формы обучения студентов от предоставления оздоровительных услуг вузом. Определены основные проблемы в организации социально-оздоровительной деятельности студентов и предложены пути их решения, включающие комплекс мероприятий по формированию мотивации студенческой молодежи к ведению здорового образа жизни. Статья предназначена для специалистов сферы образования, физической культуры и порта, здравоохранения, исследователей, студентов.
The relevance of the article is due to the contradictions between the needs of students in health improvement and the possibility of its organization in a modern higher school. The purpose of the article is a comparative analysis of the activities of universities to improve the health of students and the formation of their healthy lifestyle skills. The author defines the main activities of the university in the field of health improvement of students, the formation of their healthy lifestyle skills. The general and specific components of the social and recreational activities of universities are highlighted. The dependence of the form of students' education on the provision of health services by the university is emphasized. The main problems in the organization of social and recreational activities of students are identified and ways to solve them are proposed, including a set of measures to motivate students to lead a healthy lifestyle. The article is intended for specialists in the field of education, physical culture and sports, healthcare, researchers, students.
Analysis of experience of design the reflexive session structure
Authors: Гутник И.Ю. , Гембель Т.П. , Дмитриева Ю.И. 
Published: June 2022

В статье представлен опыт педагогического проектирования новой рефлексивной воспитательной практики – «рефлексивной сессии». Данная практика разрабатывалась с целью внедрения в образовательный процесс школы формирующего, рефлексивного педагогического диагностирования, направленного на самоопределение учеников. В статье представлена работа исследователей, осуществлявшаяся на каждом из этапов: «Предпроектном этапе – Этапе реализации проекта – Рефлексивном этапе – Послепроектном этапе». Коррекция процесса проектирования осуществлялась при помощи метода «исследования действием», который позволял оценивать эффективность работы и осуществлять ее своевременную коррекцию. В основу выделения этапов рефлексивной сессии была положена модель рефлексивного обучения Колба. В структуре сессии заложено сочетание трех ролевых позиций педагога: как наставника, как коуча и как тренера. В статье представлена итоговая структура рефлексивной сессии и описан пример одной из рефлексивных сессий.
The article presents the experience of pedagogical design of a new reflexive educational practice – "reflexive session". This practice was developed with the aim of introducing formative, reflexive pedagogical diagnostics aimed at self-determination of students into the educational process of the school. The article presents the work of researchers carried out at each of the stages: "The pre–project stage – The stage of project implementation – The Reflexive stage - the Post-Project stage". Correction of the design process was carried out using the method of "action research", which allowed to evaluate the effectiveness of the work and carry out its timely correction. The basis for the allocation of the stages of the reflexive session was based on the Kolb model of reflexive learning. The structure of the session includes a combination of three role positions of the teacher: as a mentor, as a coach and as a trainer. The article presents the final structure of the reflexive session and describes an example of one of the reflexive sessions.
Study of the sexual profile of men and women of different ages
Authors: Корецкая И.А. , Тайсаева С.Б. , Сисева Е.В. 
Published: June 2022

Актуальность статьи обусловлена важностью сексуального аспекта личности для самоидентификации, для формирования личных сексуальных предпочтений, для укрепления семейных отношений. Целью нашего исследования являлось определение сексуального профиля у мужчин и женщин. Было доказано, что значимых различий между сексуальными профилями у мужчин и женщин нет. Авторами был сделан вывод о том, что для обоих полов характерна ответственность, избирательность контактов, способность к пониманию партнеров, открытость к обсуждению вопросов сексуального характера. Отмечается более выраженная эмоциональность у женщин, для них более значима верность в отношениях. Мужчины в большей степени придерживаются традиционных взглядов на гетеросексуальные отношения. Полученные результаты позволяют сделать вывод о том, что в настоящем время сексуальное поведение мужчин и женщин имеет сходные черты и установки, что говорит больше о партнерских, а не традиционных патриархальных отношениях между мужчинами и женщинами.
The relevance of the article is due to the importance of the sexual aspect of personality for personal self-identification, for the formation of personal sexual preferences, for strengthening family relationships. The purpose of our study was to determine the sexual profile of men and women. It has been proved that there are no major differences between male and female profiles. The authors concluded that both sexes are characterized by responsibility, selectivity of contacts, the ability to understand partners, and openness to discussing issues of a sexual nature. There is a more pronounced emotionality in women, for them the price is fidelity in a relationship. Men are more likely to adhere to traditional views on heterosexual relationships. Our article is intended to work on sex education. The results obtained allow us to conclude that at the present time, the sexual behavior of men and women in general is a common life attitude regarding sexual behavior, which speaks more about partnership rather than traditional relationships between men and women.
Impelementasi Permendes PDTT No 4 Tahun 2015 di Desa Naru Kecamatan Sape Kabupaten Bima
Authors: Igul  , Yaqub Cikusin  , Yaqub  
Published: June 2022

Tujuan peneltian ini membahas tentang implementasi Peraturan Menteri Desa nomor 4 tahun 2015 tentang Pendirian, Pengurusan, dan Pengelolaan dan Pembubaran BUMDes. Dalam penelian ini, peneliti menggunakan metode deskriptif dengan pendekatan kualitatif, yakni mengambarkan beberapa kajian kebijakan publik tentang BUMDes Desa Naru. Pemerintah desa mengeluarkan peraturan yang membahas tentang pendirian, pengurusan, pengelolaan dan pembubaran BUMDes, yang tertuang dalam Permendes PDTT RI Nomor 4 Tahun 2015 tentang pendirian, pengurusan, dan pengelolaan, dan pembubaran BUMDes. Dalam sejumlah desa di Indonesia masih banyak yang gagal menerapkan Permendes PDTT, salah satunya Desa Naru. Dalam sejumlah programnya, BUMDes di Desa Naru belum memberikan kontribusi yang besar terhadap perekonomian masyarakat Desa Naru dilihat dari keterlibatan dan dampaknya terhadap masyarakat. Minimnya sosialisasi atau proses pengenalan BUMDes kepada masyarakat luas menjadi penyebab utama dalam kemajuannya serta struktur organisasi yang belum tertata dengan baik. sehingga hasil yang diharapkan tidak sesuai dengan keinginan organisasi (BUMDes).
High-pressure and high-temperature structure and equation of state of Na&lt;sub&gt;3&lt;/sub&gt;Ca&lt;sub&gt;2&lt;/sub&gt;La(CO&lt;sub&gt;3&lt;/sub&gt;)&lt;sub&gt;5&lt;/sub&gt; burbankite
Authors: Milani Sula , Spartà Deborah , Fumagalli Patrizia , Joseph Boby , Borghes Roberto , Chenda Valentina , Maurice Juliette , Bais Giorgio , Merlini Marco 
Published: June 2022

Abstract. In this study we report the synthesis of single crystals of
burbankite, Na3Ca2La(CO3)5, at 5 GPa and 1073 K.
The structural evolution, bulk modulus and thermal expansion of burbankite were
studied and determined by two separate high-pressure (0–7.07(5) GPa) and
high-temperature (298–746 K) in situ single-crystal X-ray diffraction
experiments. The refined parameters of a second-order Birch–Murnaghan
equation of state (EoS) are V0= 593.22(3) Å3 and KT0= 69.8(4) GPa. The thermal expansion coefficients of a Berman-type EoS are
α0= 6.0(2) ×10-5 K−1, α1= 5.7(7) ×10-8 K−2 and V0= 591.95(8) Å3. The thermoelastic
parameters determined in this study allow us to estimate the larger density
of burbankite in the pressure-temperature range of 5.5–6 GPa and
1173–1273 K, with respect to the density of carbonatitic magmas at the same
conditions. For this reason, we suggest that burbankite might fractionate
from the magma and play a key role as an upper-mantle reservoir of light
trivalent rare earth elements (REE3+).
PERAN ORANG TUA TERHADAP ANAK DALAM MENUNJANG PENDIDIKAN DI DESA TOMHALU KECAMATAN TOBELO SELATAN
Authors: Bubala Yurni alita , Salem Veronika , Singal Zoni Hengki 
Published: June 2022

The problem in this research is the role of parents who have a role in supporting the success of their children, especially in terms of increasing children's learning motivation. By using qualitative research methods with observation and interview techniques, the conclusions of this

research are: The role of parents in children's education is very important, not only as breadwinners for male parents and nurturing and caring for female parents, but there are several important things that can be done. encourage children to be better in their education, namely as parents, they must understand teaching children about socio-cultural, religious, and love life as well as other factors that parents must know. And applied to children. Parents act as educators because in their work not only teach, but also train children's skills, especially training children's mental attitudes.
Evaluate microbial profile and IL-17 level in transmission transfusion infection patients
Authors: Jabbar Murtadha Rahi , Darweesh Mayyada F 
Published: June 2022

Transfusion-transmitted infections (TTIs) an important causes of morbidity and mortality among recipients of blood /blood products since it among the essential vehicles for infectious agents that lead to disability or death. So this study aimed to evaluate the important causative agents and the role of IL-17 in progressive disease . A Case-control study was performed to 100 patients with Transfusion blood attended to AL-Sadder teaching hospital with group of 30 healthy individual as control. Blood sample was collected from all patients and control. IL-17 level were measured by enzyme-linked immunosorbent assay (ELISA). The result shown that Hemodialysis patients 54 (54%) patient from which 40(74%) suffering from TTI, HCV were most common causative agents with 42 % and the male recorded 63%. While 46(46%) patients with thalassemia from which 32(70%) were TTI and HCV a most common pathogen with 19(41 %), the male higher than female with frequency (65%). In conclusion: This result explain that HCV infected more than non-infected HD patients and the serum IL-17 level increased significantly in HD patients with HCV, then patients without HCV infection in comparison with healthy control group.
Rising Giants: Charting the Growth of Arbitration in Vietnam and China
Authors: Lixin Chen , Sinh Vuong Nguyen 
Published: June 2022

The appeal of arbitration, as a mode of dispute resolution, to foreign investors has led to the common wisdom that there is a broad correlation between the growth of the arbitration sector and the growth of the economy as a whole. This common wisdom is however subject of some scepticism in Asia, where arbitration and its association with the Western neoliberal project continues to raise concerns amongst some quarters. This article seeks to dispel this scepticism in the context of two Asian economic powerhouses. By tracking how the arbitration sector in both countries have evolved over time, both quantitatively and qualitatively, the authors observe that economic growth has been matched by a corresponding liberalization of the arbitration sector and the adoption of new standards, as well as the design of novel approaches worthy of consideration by other more established jurisdictions.
arbitration, Asia, Vietnam, China.
Space for Challenges: NASA’s Protest Process Makes Procurement Fairer and More Transparent
Authors: A. Melograna Catrina 
Published: June 2022

This article examines the National Aeronautics and Space Administration (NASA) procurement system broadly, starting from the top down with further examination of the protest process. It asks whether the protest process ensures fairness and transparency in the competition between commercial companies to win the contracts solicited by NASA. As a case study on the protest process, and to help answer the question, the article examines the recent Blue Origin protest regarding the Human Landing System and the SpaceX lunar lander contract award. Finally, the article concludes that the protest procedure is vital in ensuring the procurement process is fair and that NASA is held accountable for its decisions when it comes to spending public funds.
NASA Procurement System, NASA, SpaceX, Blue Origin, Protest Process