bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on Integration of Retired Lithium-Ion Battery With Photovoltaic for Net-Zero Electricity Residential Homes
Authors: Alhadri Muapper , Zakri Waleed , Farhad Siamak 
Published: September 2022

Abstract
The behavior of a retired lithium-ion battery (LIB) from its first-life in an electric aircraft (EA) to its second-life in a solar photovoltaic (PV) system for a net-zero electricity residential home is studied. The first part of this study presents the design and sizing of a battery energy storage system (BESS), made from retired LIBs, to store a portion of the PV generation for a typical home in Ohio. The home is connected to the grid, but the net electricity usage from the grid in one year is zero. The purpose of the BESS is to peak shaving, power arbitrage, reduce the home dependency on the grid, and increase the economic benefits. The sizing is determined based on the hourly data of the PV system generation, ambient temperature, irradiation, and home demand electricity. In the second part of this study, the retired LIB degradation rate and its remaining useful life in the BESS are estimated using an adopted empirical LIB model. The model includes the capacity-fade for both first-life and second-life of the LIB under various duty cycles. It is shown that the retired LIB from its first-life is still suitable to be used in the PV grid-tied battery (PVGB) system for another 10 years. The results of this study can potentially reduce the LIB cost for electric vehicles (EVs) and EAs because the retired LIBs from these applications still have value to serve for other applications such as PVGB systems for residential homes.
Heterophase Synthesis of Humic Substances at Low Substrate Concentrations and Flow-Through Conditions
Authors: Zavarzina A. G. , Demin V. V. , Belova O. V. , Leontievsky A. A. , Lisov A. V. 
Published: September 2022

Abstract—Humic substances (HS) are heterogeneous and polydisperse compounds formed in soils, sediments and waters during the decay and transformation of organic residues (the process called humification). The role of extracellular free-radical condensation reactions (secondary synthesis) in the formation of HS is a subject of debate. Here we have studied the formation of HS from a mixture of monomers under the dynamic conditions and at low substrate concentrations in the presence of laccase from the fungusCoprinus comatusF-2940. Laccase was immobilized on kaolinite modified with aluminum hydroxide. We have investigated some properties of the enzyme, reactivity of phenolic acids and amino acids in the presence of laccase. The optimum of 2.6-dimethoxyphenol (2.6-DMP) oxidation by free laccase was at pH 6.0. Upon immobilization, it shifted to the acidic region (pH 4.4), the thermal stability decreased, however the kinetic parameters of 2.6-DMP oxidation remained unchanged. In terms of reactivity (% of substrate conversion by free laccase) the individual phenolic acids formed a series: caffeic (72) > ferulic (53) > gallic = syringic (43) > protocatechuic (5.5) > vanillic = p-hydroxybenzoic (0). In the mixture of phenolic acids, gallic acid was most efficiently oxidized (50%), while the other acids were oxidized in comparable amounts (13–17%). The conversion of phenolic acids increased in the presence of lysine. When a mixture of gallic, protocatechuic, syringic, ferulic acids (0.01 mM each) and lysine (0.02 mM) was passed through a flow-through microcolumn, immobilized laccase effectively oxidized the phenolic acids, the reaction products bound to the mineral phase, staining it dark. According to high performance liquid chromatography, the molecular weights of compounds extracted from the mineral phase did not exceed 900 Da, thus fulvic acid-like substances were formed. Results of the study suggest an important role of free-radical heterophase reactions in the formation of the molecular composition of the liquid phase and organo-mineral complexes.
Study protocol for a multicentre nationwide prospective cohort study to investigate the natural course and clinical outcome in benign liver tumours and cysts in the Netherlands: the BELIVER study
Authors: Furumaya Alicia , Haring Martijn P D , van Rosmalen Belle V , Klompenhouwer Anne J , Besselink Marc G , de Man Robert A , IJzermans Jan N M , Thomeer Maarten G J , Kramer Matthijs , Coolsen Mariëlle M E , Tushuizen Maarten E , Schaapherder Alexander F , de Haas Robbert J , Duiker Evelien W , Kazemier Geert , van Delden Otto M , Verheij Joanne , Takkenberg R Bart , Cuperus Frans J C , De Meijer Vincent E , Erdmann Joris I 
Published: September 2022

IntroductionBenign liver tumours and cysts (BLTCs) comprise a heterogeneous group of cystic and solid lesions, including hepatic haemangioma, focal nodular hyperplasia and hepatocellular adenoma. Some BLTCs, for example, (large) hepatocellular adenoma, are at risk of complications. Incidence of malignant degeneration or haemorrhage is low in most other BLTCs. Nevertheless, the diagnosis BLTC may carry a substantial burden and patients may be symptomatic, necessitating treatment. The indications for interventions remain matter of debate. The primary study aim is to investigate patient-reported outcomes (PROs) of patients with BLTCs, with special regards to the influence of invasive treatment as compared with the natural course of the disease.Methods and analysisA nationwide observational cohort study of patients with BLTC will be performed between October 2021 and October 2026, the minimal follow-up will be 2 years. During surveillance, a questionnaire regarding symptoms and their impact will be sent to participants on a biannual basis and more often in case of invasive intervention. The questionnaire was previously developed based on PROs considered relevant to patients with BLTCs and their caregivers. Most questionnaires will be administered by computerised adaptive testing through the Patient-Reported Outcomes Measurement Information System. Data, such as treatment outcomes, will be extracted from electronic patient files. Multivariable analysis will be performed to identify patient and tumour characteristics associated with significant improvement in PROs or a complicated postoperative course.Ethics and disseminationThe study was assessed by the Medical Ethics Committee of the University Medical Center Groningen and the Amsterdam UMC. Local consultants will provide information and informed consent will be asked of all patients. Results will be published in a peer-reviewed journal.Study registrationNL8231—10 December 2019; Netherlands Trial Register.
Effectiveness of linkage to care and prevention interventions following HIV self-testing: a global systematic review and meta-analysis protocol
Authors: Bain Luchuo Engelbert , Amu Hubert , Dowou Robert Kokou , Memiah Peter , Agbor Valirie Ndip 
Published: September 2022

IntroductionEarly identification of persons living with HIV (PLWH) is crucial to institute timely treatment to prevent HIV-related morbidity and mortality. The convenience, flexibility and confidentiality of HIV self-testing enhance the acceptability of HIV testing and early detection of PLWH. However, persons who tested positive after a self-test are more likely to present late for treatment. This review seeks to evaluate the effectiveness of interventions to improve linkage to care and prevention after self-testing.Methods and analysisWe will search PubMed, Embase, Web of Science, Cochrane Library, PsycInfo, Global Health Library, ClinicalTrials.gov and current controlled trials for all randomised and non-randomised studies published from 1 January 2010 to 31 July 2022 without language restriction. Two review authors will independently screen and select articles (based on the eligibility criteria for this review), extract data and assess the risk of bias in the included studies. Study-specific estimates will be converted to log risk ratios and weighted by the inverse of the variance of the log risk ratio before pooling into a fixed-effect model. The Cochrane’s Q χ2test and the I2statistic will be used to assess and quantify heterogeneity in the included studies, respectively. The Egger’s test and funnel plots will be used to assess publication bias. Sensitivity analysis will be conducted using leave-one-out analysis to assess the impact of outliers on the overall summary intervention effect.Ethics and disseminationNo ethical clearance is needed for the current study as it will be based on already published articles. We will publish the findings of this study in international peer-reviewed journals and present them at conferences.
Cross-sectional study investigating the prevalence and causes of vision impairment in Northwest Portugal using capture–recapture
Authors: Ramos Pedro Lima , Santana Rui , Marques Ana Patricia , Sousa Ines , Rocha-Sousa Amandio , Macedo Antonio Filipe 
Published: September 2022

ObjectivesThe aim of this study was to estimate the prevalence and causes of vision impairment (VI) in Portugal.SettingInformation about people with VI was obtained from primary care centres, blind association (ACAPO) and from hospitals (the PCVIP study) in the Northwest of Portugal during a period spanning years 2014–2015. Causes of VI were obtained from hospitals.ParticipantsAdministrative and medical records of people with visual acuity in the better seeing eye of 0.5 decimal (0.30logMAR) or worse and/or visual field less than 20° were investigated. Capture–recapture with log-linear models was applied to estimate the number of individuals missing from lists of cases obtained from available sources.Primary and secondary outcome measuresLog-linear models were used to estimate the crude prevalence and the category specific prevalence of VI.ResultsCrude prevalence of VI was 1.97% (95% CI 1.56% to 2.54%), and standardised prevalence was 1% (95% CI 0.78% to 1.27%). The age-specific prevalence was 3.27% (95% CI 2.36% to 4.90%), older than 64 years, 0.64% (95% CI 0.49% to 0.88%), aged 25–64 years, and 0.07% (95% CI 0.045% to 0.13%), aged less than 25 years. The female-to-male ratio was 1.3, that is, higher prevalence among females. The five leading causes of VI were diabetic retinopathy, cataract, age-related macular degeneration, glaucoma and disorders of the globe.ConclusionsThe prevalence of VI in Portugal was within the expected range and in line with other European countries. A significant number of cases of VI might be due to preventable cases and, therefore, a reduction of the prevalence of VI in Portugal seems possible. Women and old people were more likely to have VI and, therefore, these groups require extra attention. Future studies are necessary to characterise temporal changes in prevalence of VI in Portugal.
Association of area-level education with the regional growth trajectories of rates of antibacterial dispensing to patients under 3 years in Norway: a longitudinal retrospective study
Authors: Svalestuen Sigbjørn , Svendsen Kristian , Eggen Anne Elise , Småbrekke Lars 
Published: September 2022

ObjectiveTo examine the association between area-level education and the local growth trajectories in antibacterial dispensing rates in Norwegian municipalities among children under 3 years old.DesignRetrospective, longitudinal study using individual primary care prescription data from the Norwegian Prescription Database for the period 2006–2016. Data were collected on the date of dispensing, the type and amount of antibiotic, the patient’s age, sex and municipality of residence and linked to municipality-level statistics on education available from Statistics Norway. We used multilevel growth curve modelling, with a linear trend variable modelled as a random effect and a cross-level interaction between linear trends and the proportion of the population in the municipality having received a university or college education.SettingThe local government level in Norway. The sample includes all municipalities over the study period.Outcome measureNumber of dispensed antibacterial prescriptions per 100 children in individual primary care by municipality and year.ResultsWe identified a significant negative linear trend in the square root of the dispensing rate for children under 3 years old during the period. This trend varied between municipalities. A negative cross-level interaction term between population education levels and random trends showed that municipalities with an average level of population education saw a reduction in their square root dispensing rates of −0.053 (95% CI −0.066 to −0.039) prescriptions per 100 children. Each additional percentage point in population education contributed a further −0.0034 (95% CI −0.006 to –0.001) reduction to the square root dispensing rate.ConclusionsMunicipalities in which a larger proportion of the local population have high educational achievements have been more successful in reducing antibacterial dispensing rates in children under 3 years old. Adopting area-level strategies and addressing local community disadvantages may help to optimise practices and prescribing patterns across local communities.
Develop an ADR prediction system of Chinese herbal injections containing Panax notoginseng saponin: a nested case–control study using machine learning
Authors: Wu Xing-Wei , Zhang Jia-Ying , Chang Huan , Song Xue-Wu , Wen Ya-Lin , Long En-Wu , Tong Rong-Sheng 
Published: September 2022

ObjectiveThis study aimed to develop an adverse drug reactions (ADR) antecedent prediction system using machine learning algorithms to provide the reference for security usage of Chinese herbal injections containing Panax notoginseng saponin in clinical practice.DesignA nested case–control study.SettingNational Center for ADR Monitoring and the Electronic Medical Record (EMR) system.ParticipantsAll patients were from five medical institutions in Sichuan Province from January 2010 to December 2018.Main outcomes/measuresData of patients with ADR who used Chinese herbal injections containing Panax notoginseng saponin were collected from the National Center for ADR Monitoring. A nested case–control study was used to randomly match patients without ADR from the EMR system by the ratio of 1:4. Eighteen machine learning algorithms were applied for the development of ADR prediction models. Area under curve (AUC), accuracy, precision, recall rate and F1 value were used to evaluate the predictive performance of the model. An ADR prediction system was established by the best model selected from the 1080 models.ResultsA total of 530 patients from five medical institutions were included, and 1080 ADR prediction models were developed. Among these models, the AUC of the best capable one was 0.9141 and the accuracy was 0.8947. According to the best model, a prediction system, which can provide early identification of patients at risk for the ADR of Panax notoginseng saponin, has been established.ConclusionThe prediction system developed based on the machine learning model in this study had good predictive performance and potential clinical application.
Impact of conventional lipid-lowering therapy on circulating levels of PCSK9: protocol for a systematic review and meta-analysis of randomised controlled trials
Authors: Luo Jichang , Huang Tianze , Xu Ran , Wang Xue , Yang Yutong , Li Long , Zhang Xiao , Zhang Yinhang , Yang Renjie , Wang Jie , Yang Hai , Ma Yan , Yang Bin , Wang Tao , Jiao Liqun 
Published: September 2022

IntroductionConventional lipid-lowering agents, including statins, ezetimibe, fibrates, bile acid sequestrants, nicotinic acid, bempedoic acid and Omega-3, are essential to the management of dyslipidaemia. However, these agents have been shown to increase the level of plasma proprotein convertase subtilisin/kexin 9 (PCSK9), a serine protease associated with increased cardiovascular risk. This review aims to investigate the impact of commonly available conventional lipid-lowering agents on circulating PCSK9 levels and lipid profiles.Methods and analysisThis protocol is conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines. A systematic search will be conducted in the following databases: MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, Web of Science, SCOPUS and ScienceDirect. Additional information will be retrieved from clinical trial registries or from reference list searches. Published and peer-reviewed randomised controlled trials with adults receiving statin, ezetimibe, fibrate, bile acid sequestrant, nicotinic acid, bempedoic acid or Omega-3 monotherapy or in combination for at least 2 weeks, with availability of plasma PCSK9 at the beginning and end of treatment or the net changes in values, will be included. Study selection, data extraction and assessment of the risk of bias will be independently conducted by two investigators. Continuous data will be presented as a standardised mean difference with 95% confidence interval (CI) and dichotomous data as risk ratios with 95% CI. Subgroup analysis and sensitivity analysis will be performed when sufficient studies are included. Publication bias will be assessed with a funnel plot and Egger’s test.Ethics and disseminationEthics approval is not required as this review will only include data from published sources. The results will be published in a peer-reviewed journal.Patient and public involvementNo patient or members of the general public are involved.PROSPERO registration numberCRD42022297942.
Protocol for the Tessa Jowell BRAIN MATRIX Platform Study
Authors: Watts Colin , Savage Joshua , Patel Amit , Mant Rhys , Wykes Victoria , Pohl Ute , Bulbeck Helen , Apps John , Sharpe Rowena , Thompson Gerard , Waldman Adam D , Ansorge Olaf , Billingham Lucinda 
Published: September 2022

IntroductionGliomas are the most common primary tumour of the central nervous system (CNS), with an estimated annual incidence of 6.6 per 100 000 individuals in the USA and around 14 deaths per day from brain tumours in the UK. The genomic and biological landscape of brain tumours has been increasingly defined and, since 2016, the WHO classification of tumours of the CNS incorporates molecular data, along with morphology, to define tumour subtypes more accurately. The Tessa Jowell BRAIN MATRIX Platform (TJBM) study aims to create a transformative clinical research infrastructure that leverages UK National Health Service resources to support research that is patient centric and attractive to both academic and commercial investors.Methods and analysisThe TJBM study is a programme of work with the principal purpose to improve the knowledge of glioma and treatment for patients with glioma. The programme includes a platform study and subsequent interventional clinical trials (as separate protocols). The platform study described here is the backbone data-repository of disease, treatment and outcome data from clinical, imaging and pathology data being collected in patients with glioma from secondary care hospitals. The primary outcome measure of the platform is time from biopsy to integrated histological–molecular diagnosis using whole-genome sequencing and epigenomic classification. Secondary outcome measures include those that are process centred, patient centred and framework based. Target recruitment for the study is 1000 patients with interim analyses at 100 and 500 patients.Ethics and disseminationThe study will be performed in accordance with the recommendations guiding physicians in biomedical research involving human subjects, adopted by the 18th World Medical Association General Assembly, Helsinki, Finland and stated in the respective participating countries’ laws governing human research, and Good Clinical Practice. The protocol was initially approved on 18 February 2020 by West Midlands – Edgbaston Research Ethics Committee; the current protocol (v3.0) was approved on 15 June 2022. Participants will be required to provide written informed consent. A meeting will be held after the end of the study to allow discussion of the main results among the collaborators prior to publication. The results of this study will be disseminated through national and international presentations and peer-reviewed publications. Manuscripts will be prepared by the Study Management Group and authorship will be determined by mutual agreement.Trial registration numberNCT04274283, 18-Feb-2020;ISRCTN14218060, 03-Feb-2020.
Understanding the value of non-specific abnormal capillary dilations in presence of Raynaud’s phenomenon: a detailed capillaroscopic analysis
Authors: Pacini Greta , Pogna Andrea , Pendolino Monica , Pizzorni Carmen , Carmisciano Luca , Gotelli Emanuele , Sulli Alberto , Paolino Sabrina , Schenone Carlotta , Smith Vanessa , Cutolo Maurizio 
Published: September 2022

BackgroundNailfold videocapillaroscopy (NVC) non-specific abnormalities may be present in subjects with isolated Raynaud’s phenomenon (RP) before the potential transition to systemic sclerosis (SSc) specific microvascular alterations (‘scleroderma pattern’). This study aims to investigate NVC non-specific abnormalities, notably capillary dilations, in RP patients, as possible forerunners of the ‘scleroderma pattern’.MethodsA 10-year retrospective NVC-based investigation evaluated 55 RP patients sorted into 3 sex-matched and age-matched groups according to clinical evolution: 18 later developing SSc (cases), 19 later developing other connective tissue disease and 18 maintaining primary RP at long-term follow-up (controls). All patients had a basal NVC showing non-specific abnormalities, namely non-specific >30 µm dilated capillaries (30–50 μm diameter). Sequential NVCs were longitudinally evaluated using current standardised approach. Statistical analysis assessed the risk for developing a ‘scleroderma pattern’.ResultsSignificantly larger capillary diameters were observed in cases versus controls both at basal NVC and during follow-up NVC (p=<0.05 to <0.001). Interestingly, controls showed stable NVC non-specific abnormalities over the study follow-up. The number of >30 µm dilated capillaries/mm at basal NVC was the strongest single predictor of ‘scleroderma pattern’ evolution with 24% increased risk per each dilated capillary (OR 1.24, 95% CI 1.17,1.32). Additionally, a tree-based analysis suggested the efferent (venous) diameter of the most dilated capillary on basal NVCas a variable of interest to identify patients maintaining primary RP.ConclusionThis is the first study to describe an NVC ‘prescleroderma signature’ to potentially identify RP patients later developing a ‘scleroderma pattern’.