bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of single-level lumbar spondylolisthesis by percutaneous endoscopic decompression and fusion (PE-PLIF)
Authors: Gao Zhenwu , Xi Leimin , Feng Haoyu , He Liming , Ma Yongzhuang , Chang Qiang , Wang Rui , Wang Yue 
Published: July 2022

Abstract
Purpose: To investigate the effect of percutaneous endoscopic lumbar decompression and fusion (PE-PLIF) for L4/5 lumbar spondylolisthesis.
Methods: From September 2019 to June 2020, six patients (two men, four women) with l4/5 lumbar spondylolisthesis from the Department of Orthopedics, Bethune Hospital of Shanxi Province were treated with PE-PLIF. Their ages ranged from 43 to 77 years, with an average of (59.66±17.33) years. The duration of operation, blood loss, blood transfusion, and complications were recorded. Results were evaluated by visual analogue scale (VAS) and Oswestry Disability Index (ODI). Student's t- test was used to compare the parameters before and after operation.
Results: Six patients were followed up for an average of 13 months (6~20 months), and their symptoms were significantly improved. VAS scores of low back pain and leg pain at three days (2.19±0.49, 1.47±0.63, respectively) and 24 months (0.41±0.54, 0.24±0.27, respectively) were significantly improved compared with preoperative scores (7.83 ±1.17, 6.50±0.80, respectively). The differences were statistically significant ( t =18.717, 6.771, 17.511, 8.021, all P < 0.001). The ODI score at the last follow-up was also significantly lower than that before surgery (53% ±9% vs 17%±7%, P < 0.001). During the follow-up period, screw extraction occurred in only one patient, and no obvious complications occurred in the other five patients. No complications occurred.
Conclusion: PE-PLIF can achieve satisfactory short-term efficacy in the treatment of single-level lumbar spondylolisthesis with a low complication rate and quick postoperative recovery. It is a safe and effective way to treat single-level lumbar spondylolisthesis.
Hypertensive Retinopathy in Patients With Indications for Kidney Transplantation: A Cross-sectional Study
Authors: Nguyen Le Trung , Toan Pham Quoc , Tuan Vu Anh , Trung Nguyen Kien 
Published: July 2022

Abstract
Purpose: Patients with end-stage renal failure are very susceptible to hypertensive retinopathy. This study explores the relationship between hypertensive retinopathy and risk factors.Methods: The 115 patients with end-stage renal failure are indicated for a kidney transplant. The outcome variable was the hypertensive retinopathy condition of the participants. Wong's classification of hypertensive retinopathy. Using linear regression to evaluate the associationResults: According to levels, the rate of retinal damage due to hypertension is 65.22%. When univariate analysis found the level of visual acuity was statistically significant, the other factors were not statistically significant. In multivariable logistic regression analysis, sex (odds ratio: 3.4, p<0.05), hemodialysis (odd ratio: 3.5, p<0.05), visual acuity (odd ratio: 14.0, p<0.05) is considered to be an influence factor for disease progression.Conclusion: Sex, hemodialysis, visual acuity are factors for hypertensive retinopathy in patients preparing to receive a kidney. These results reinforce the evidence for multifactorial hypertensive retinopathy disease in patients with renal impairment.
The P2Y12 receptor antagonist Ticagrelor ameliorates pulmonary hypertension
Authors: Li Nannan , Yin Jie , Shi Yugen , Sun Li , Zhang Qingshan , Bao Shuai , Zhang Juan , Li Youlei , Wang Miaomiao , Zhang Yanwei , Feng Xue , Cai Weidong , Zhang Hongxing , Li Yan , Yan Suhua , You Shuling , Li Xiaolu 
Published: July 2022

Abstract
Purpose
Pulmonary arterial hypertension (PAH) is a disease that the pulmonary artery is abnormally elevated. P2Y12 is an adenosine diphosphate (ADP) receptor and it act as the target of thienopyridine antiplatelet drugs by controlling vascular remodeling. Inhibition of P2Y12 receptor in the process of PAH was explored in this study.
Methods
The PAH model was established in Sprague-Dawley rats by single subcutaneous injection of 60 mg/kg monocrotaline (MCT). The ticagrelor solution (a selective P2Y12R inhibitor) was intraperitoneally injected into rats at a dose of 14 mg/kg from the time of MCT injection to day 28.
Results
In the lung tissues of PAH rats, the marked P2Y12R was detected. Treatment with ticagrelor greatly decreased P2Y12R level and efficiently abolished the upregulation of α-SMA as demonstrated by Western blot and RT-PCR. The wall thickness and occlusion score of the pulmonary arterioles showed that blockade of P2Y12R could relieve lung remodeling caused by PAH. The haemodynamic changes at 4 weeks determined that P2Y12R inhibition affected RV pressure and right heart hypertrophy.
Conclusions
P2Y12R might be involved in the pathogenesis of PAH. Blockade of P2Y12R has potential in treating PAH.
Tingkatan sosial ekonomi orangtua berdampak pada kemampuan belajar siswa di masa pandemi Covid-19
Authors: Febriani Bunga Anggun , Anshori Isa 
Published: July 2022

Dalam lingkungan masyarakat tingkatan sosial ekonomi setiap orangtua berbeda-beda. Terdapat tingkat sosial ekonomi atas, menengah, dan bawah semua itu berdampak pada kehidupan sosial serta pendidikan anak. Perbedaan tingkatan kelas sosial orangtua nantinya berpengaruh terhadap kemampuan belajar siswa. Namun saat ini dunia sedang digemparkan oleh adanya pandemic covid-19 yang mengakibatkan proses pembelajaran harus dilakukan dengan metode daring. Tetapi metode pembelajaran daring memiliki beberapa permasalahan yang cukup krusial untuk dibahas. Tujuan dari kajian ini adalah untuk mengetahui dan menjelaskan berbagai permasalahan yang dihadapi oleh dunia pendidikan atas pandemic covid-19 terutama dalam ketidaksetaraan yang dirasakan oleh para murid untuk menerima materi pembelajaran secara daring (online) dirumah. Dengan mengetahui berbagai permasalahan yang dihadapi para murid dalam mengikuti proses pembelajaran daring diharapkan pemerintah dapat memperbaiki dan meningkatkan kualitas pendidikan secara merata. Penelitian ini menggunakan metode kualitatif dengan pendekatan secara deskriptif. Penelitian kualitatif ini merupakan suatu langkah yang ditempuh guna memperoleh isi dari komunikasi yang disampaikan oleh peneliti dalam bentuk wawancara maupun pengajuan pertanyaan kepada informan. Hasil penelitian ini menyatakan bahwa kemampuan belajar siswa tergantung pada status sosial orangtua. AbstractIn the social environment, the socioeconomic level of each parent is different. There are socioeconomic levels above, middle, and below all that have an impact on social life and children's education. The difference in the level of parental social class will affect the learning ability of students. However, the world is currently in an uproar by the co-19 pandemic which has resulted in an online learning process. But online learning methods have some issues that are crucial enough to be discussed. The purpose of this study is to find out and explain the various problems faced by the education world of the co-19 pandemic, especially in the inequality felt by students to receive online learning material at home. By knowing the various problems faced by students in participating in the online learning process, it is hoped that the government can improve and improve the quality of education equally. This research uses a qualitative method with a descriptive approach. This qualitative research is a step taken to obtain the contents of communication delivered by researchers in the form of interviews and asking questions to informants. The results of this study stated that the student's learning ability depends on the social status of parents.
Pengembangan bumiku sebagai media pembelajaran lingkungan hidup di sekolah dasar
Authors: Halimah Ima Siti , Djumhana Nana , Saputri Aprilia Eki , Damayanti Mela 
Published: July 2022

Media pembelajaran sebagai alat penunjang penyampaian pembelajaran menjadi bagian yang penting dalam penelitian ini khususnya bagi pembelajaran Pendidikan Lingkungan Hidup yang bersifat kontekstual dan mendorong siswa sekolah dasar untuk mengenali masalah lingkungan di sekitarnya. Bumiku sebagai rancangan media pembelajaran yang berupa buku harian interaktif disusun sesuai dengan aspek lingkungan hidup yang berkenaan langsung dengan siswa. Menggunakan metode kualitatif dengan tahapan perencanaan, produksi, dan evaluasi sebagai tahapan dan proses rancangan Bumiku. Hasil penelitian berupa media grafis berbentuk buku harian interaktif dengan isi konten berupa pertanyaan dan artikel pendek berdasarkan aspek lingkungan yang berkenaan dan berdampak langsung pada kehidupan siswa sekolah yang diantaranya energi listrik, sampah, kondisi alam, sanitasi, dan pemanasan global.AbstractLearning media as a means of supporting the delivery of learning is an important part of this study, especially for learning contextual environmental education and encouraging elementary school students to recognize environmental problems in their surroundings. Bumiku as a learning media design in the form of an interactive diary arranged in accordance with environmental aspects that are directly related to students. Using qualitative methods with the planning, production, and evaluation stages as the process of the Bumiku design. The results of the research are graphic media in the form of interactive diaries with content in the form of questions and short articles based on environmental aspects that have a direct impact on the lives of school students, including electrical energy, waste, natural conditions, sanitation, and global warming
Pale to Pink: Where are we going with the fetomaternal care? A perinatal mortality audit of a tertiary care hospital in coastal Karnataka in India for 2019-2020 By Dr. S. Kanchan (SR), Dr. V. Jatana (JR), Dr. MV Pai (HOD) Dept of OBG, KMC Manipal,
Authors: Kanchan Swati , Jatana Vaishnavi , Pai Murlaidhar 
Published: July 2022

Perinatal Mortality Rate is an important epidemiological indicator of
Maternal and Child Health care because of its sensitivity for both
maternal and new-born care. To analyse trends of perinatal morbidity and
mortality, 4177 deliveries were studied across 18 months in a tertiary
care hospital in Karnataka. Fetal growth restriction accounted to more
than 50% of the perinatal deaths. Maternal morbidities were associated
with up to 40.6% of causes for still birth. Preterm births account to
45.3% of neonatal deaths, sepsis accounting to 20.31%. Early
recognition and intervention for these conditions seemed to be the
mainstay in improving perinatal outcome.
Mandibular retromolar space in adults with different sagittal skeletal patterns: Cone-beam computed tomography analysis
Authors: Fan Zeng , Zhang Qi , Jiang Yujun , Qin Qianyi , Huang Sheng , Guo Jie 
Published: July 2022

ABSTRACT

Objectives
To analyze the mandibular retromolar space among normal-divergent adult patients with different sagittal skeletal patterns by cone-beam computed tomography (CBCT).

Materials and Methods
CBCTs of a total of 120 normal-divergent adult patients were investigated. Patients were categorized into the following three groups according to their ANB angle: skeletal Class I (48 patients), skeletal Class II (36 patients), and skeletal Class III (36 patients). Four different planes parallel to the mandibular occlusal plane were used to measure the retromolar space. The retromolar space was measured by two reference lines and then compared between different sagittal skeletal patterns groups. The incidence of root contact with the inner lingual cortex was compared among the three groups.

Results
The retromolar space of the Class III patients was significantly larger than that of Class I patients and Class II patients. Compared with Class I and Class III patients, Class II patients had a smaller retromolar space and higher incidence of contact with the inner cortex of the mandible.

Conclusions
Class III patients had a larger retromolar space than Class I patients and Class II patients in four different planes. The mandibular retromolar space should be evaluated by CBCT in patients who need mandibular molar distalization.
Sustained pro-inflammatory effects of hypoglycemia in people with type 2 diabetes and in people without diabetes
Authors: Verhulst Clementine E.M. , Heck Julia I.P. van , Fabricius Therese W. , Stienstra Rinke , Teerenstra Steven , McCrimmon Rory J. , Tack Cees J. , Pedersen-Bjergaard Ulrik , Galan Bastiaan E. de 
Published: July 2022

<p>Iatrogenic hypoglycaemia activates the immune system and is associated with an increased risk for atherosclerotic disease. We determined acute and long-term effects of insulin-induced hypoglycemia on inflammatory markers in humans with or without type 2 diabetes. Fifteen adults with type 2 diabetes and 16 matched controls (M/F 17/14, age 59.6±7.1 years, BMI 28.5±4.3 kg/m2) underwent a hyperinsulinemic-euglycemic (5.31±0.32 mmol/L) hypoglycemic (2.80±0.12 mmol/L) glucose clamp. Blood was drawn during euglycemia and hypoglycemia and 1, 3 and 7 days later, to determine circulating immune cell composition, function, and inflammatory proteins. In response to hypoglycemia, absolute numbers of circulating lymphocytes and monocytes significantly increased and remained elevated for one week. The proportion of CD16+-monocytes increased, and the proportion of CD14+-monocytes decreased, which sustained for a week in people without diabetes. During hypoglycemia, ex vivo stimulated, monocytes released more TNF-α and IL-1β, and less IL-10, particularly in people with diabetes. Hs-CRP and 25 circulating inflammatory proteins increased, remaining significantly elevated one week after hypoglycemia. While levels at euglycemia differed, responses to hypoglycemia were broadly similar in people with or without type 2 diabetes. We conclude that hypoglycemia induces a pro-inflammatory response at the cellular and protein level that is sustained for one week in people with type 2 diabetes and controls. </p>
An Immersive Virtual Reality System For Practicum Chair Assembly Training To Increase Effectiveness of PPTI 2
Authors: Huda Vani Aditiya Nur , Susmartini Susy , Herdiman Lobes 
Published: July 2022

The implementation of practicum chair assembly training in PPTI 2 still uses conventional method training. The use of conventional methods has some drawbacks including high resource requirements when starting out and requires an experienced coach who should always be there whenever there is training. The use of conventional methods in the training of practicum chair assembly is considered less effective. There needs to be other alternatives in practicum chair assembly training. The alternative chosen is training using Virtual reality (VR). This paper contains a comparison between training using conventional methods and using virtual reality. That proves training uses VR more effectively than training with conventional methods.
Content and Context
Authors: Li Mingyan , Seneca Tracy , Keller Young Megan 
Published: July 2022

This paper demonstrates how taking differences in end user behavior and differing interdepartmental perspectives on metadata into account can strengthen the digital object workflow to serve a greater variety of users. The University of Illinois Chicago University Library has successfully collaborated on metadata initiatives since establishing a cross-departmental Metadata Working Group. The article examines the perspectives of archivists, digital librarians, and catalogers on digital object metadata. It outlines the workflow established to enable each of these stakeholders to contribute their unique strengths to metadata and considers how bringing those strengths together serves different end user groups. It presents two examples of this workflow in action and considers the next steps for improving that workflow. Future efforts to strengthen the content/context balance of metadata are discussed in three areas: aggregated digitization and description, technology enhancements, and moving from a linear to a circular workflow model.
Endoscopic Prophylaxis and Treatment of Portal-Genesis Oesophageal Haemorrhage
Authors: Bebezov B. Kh. , Sultangaziev R. A. , Abdykadyrov T. A. 
Published: July 2022

Background. Portal hypertension-triggered oesophageal and gastric variceal bleeding is the most dangerous and threatening complication, with an up to 50–70 % mortality at first episode. High-mortality repeated bleeding develops subsequently in 30–50 % patients, with the proved 100 % recurrence rate in the first two years following the first episode. The world experience dictates further research to continue towards developing new surgical methods and approaches.Aim: to evaluate the treatment efficacy of pneumatic endoscopic band ligation of bleeding oesophageal varices (OV).Materials and methods. The experience of applying pneumatic endoscopic ligation treatment in the patients managed at the General Surgery Unit of the Clinical Hospital of the Kyrgyz Republic Presidential Administration during 2017–2019 was analysed. Endoscopic ligation is a modern minimally invasive and less traumatic intervention used to markedly reduce mortality and improve quality of life in patients with portal hypertension syndrome. The evidence on 76 patients following endoscopic OV ligation was summarised. The patient age ranged from 11 to 70 years (mean 46.26 years); 40 men (52.6 %) and 36 women (47.4 %) were included. Among the 76 patients, portal hypertension was caused by viral cirrhosis in 38, hepatitis B in 5, delta agent hepatitis B in 18, hepatitis C in 13, a hepatitis B–C combination in 1 and a delta agent hepatitis B — hepatitis C combination in 1 patient. In 21 patients, cirrhosis was of unknown aetiology. A portal vein malformation was observed in 13 people of whom 4 had it combined with thrombosis.Results. A total of 94 ligation procedures were performed in 76 patients with grade II–III OV. Some patients needed to undergo the procedure several times, 18 patients had 2 sessions. Two cases required 3 and 4 sessions each. Moderate oesophageal soreness was reported in 32 patients for 1–6 days following the ligation. No complications were registered during the operation. In early postoperative period, 2 patients developed recurrent bleeding, with haemostasis re-achieved by a repeated vein ligation below bleeding.Conclusion. Hence, small invasiveness and minor traumatism coupled with high efficiency and lesser complications render endoscopic ligation the method of choice in primary and secondary prophylaxis and treatment of OV. Endoscopic ligation improves the patient’s quality of life, allows an extra time for conservative treatment and longer period to liver transplantation.
Informativity of Locally Estimated Odd-Numbered Higher Fatty Acids for Differential Diagnosis of HSIL and Cervical Cancer
Authors: Kayukova E. V. , Belokrinitskaya T. E. , Ziganshin A. M. , Mudrov V. A. 
Published: July 2022

Background. Current issues in the cytological assessment of cervical epithelium can hamper differential diagnosis of high-grade squamous intraepithelial lesion (HSIL) and cervical cancer.Aim. To determine the informativity of locally estimated values of odd-numbered higher fatty acids as differential markers in HSIL and cervical cancer.Materials and methods. Previous original data on the higher fatty acids content in cervical biopsy of primary pre-treatment HSIL and cervical cancer patients were analysed retrospectively. The study cohorts: clinical cohort I — 30 HSIL patients; clinical cohort II — 45 primary stage I squamous cervical cancer patients. Statistical methods included the analyses of ROC curves, sensitivity (Se), specificity (Sp) and accuracy (Ac).Results. Among all odd-numbered higher fatty acids, the following molecular markers (local thresholds) are differential for cervical cancer: C15:0 ≤1.91 %/cell (Se = 0.81; Sp = 0.84; Ac = 0.83; AUC = 0.81); C15:1 ≤1.72 %/cell (Se = 0.96; Sp = 0.91; Ac = 0.92; AUC = 0.96); C17:0 ≤2.95 %/cell (Se = 0.94; Sp = 0.93; Ac = 0.97; AUC = 0.97); C17:1 ≤1.11 %/cell (Se = 0.96; Sp = 0.98; Ac = 0.96; AUC = 1.0); C19:0 ≤1.17 %/cell (Se = 1.0; Sp = 1.0; Ac = 1.0; AUC = 1.0).Discussion. Tumour cells are known to possess atypical metabolism, which produces large amounts of higher fatty acids with odd numbers of carbon atoms. The study focused on the value of locally estimated odd-numbered higher fatty acids as differential molecular markers in HSIL and cervical cancer.Conclusion. The results suggest that C19:0 estimates are applicable in diagnosis of HSIL and cervical cancer.
ETHNOBOTANICAL STUDY OF PANDANACEAE BY THE BESEMAH TRIBE, LAHAT DISTRICT, SOUTH SUMATERA PROVINCE
Authors: Tanzerina Nina , Harmida Harmida , Apriliani Dwi 
Published: July 2022

The research entitled Ethnobotanical study of Pandanaceae by the Besemah tribe in Lahat Regency, South Sumatra has been conducted form October 2018 to December 2019. The objective of the research were to inventory the species diversity of Pandanaceae and its traditional utilization by the local ethnic in the studied area. The research was conducted by using survey method and field work to collect plant samples. The basic data of ethnobotany was collected by using direct interview from respondents. The result showed that there were six (6) species of Pandanaceae such as; Pandanus lais Kurz, Pandanus helicopus Kurz, Pandanus amaryllifolius Roxb. (two varieties; “large and small” size fragrant pandanus), Benstonea atrocarpa Griff, Benstonea affinis Kurz. and Freycinetia rigidifolia Hemsl. 71,4% of them were belonged to wild species and 28.8% were cultivated species. The trdaitional utilization of Pandanaceae was used for handycrafft (36.4%), building material (9,1%), medicinal & cosmetic ingredients, foodstuffs and customary materials (18.2% each). The Baeemah tribe was used leaves (75%) rather than other part of plant.
Identification and comparison of characteristics of inflation rate in cities in Indonesia in the period of 2009–2014 with the period of 2014–2019
Authors: Setiawan Adi , Wijayanto Bayu , Wattimanela Henry Junus 
Published: July 2022

This study aims to identify the characteristics of the MoM inflation rate in cities in Indonesia. In addition, it also compares the distribution of the monthly inflation rate for the 2009–2014 period with the 2014-2019 period in cities in Indonesia. The method used to identify the characteristics of the MoM inflation rate is by using summary of statistics, while to compare the distribution of the monthly inflation rate for the 2009–2014 period and the 2014–2019 period, the two-sample Kolmogorov-Smirnov test is used. Characteristics of the month to month (MoM) inflation rate in cities in Indonesia for the period October 2009 to March 2019 was presented. Furthermore, the comparison of the characteristics of the MoM inflation rate from October 2009 to September 2014 (period 1) and the period from October 2014 to March 2019 (period 2) was also shown. The cities of Banda Aceh, Kendari, Yogyakarta, Jakarta and Sorong had an average characteristic of inflation each month which tended to be low in February, March, April and September.Six cities had significantly different characteristics during period 2 inflation rate compared to period 1.