bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomic profiling of circulating plasma exosomes reveals novel biomarkers of Alzheimer’s disease
Authors: Cai Huimin , Pang Yana , Wang Qi , Qin Wei , Wei Cuibai , Li Ying , Li Tingting , Li Fangyu , Wang Qigeng , Li Yan , Wei Yiping , Jia Longfei 
Published: December 2022

AbstractBackgroundNeuronal- and astrocyte-derived exosomes have been identified as an optimal source for screening biomarkers for Alzheimer’s disease (AD). However, few studies focus on the bulk exosome population isolated from plasma of AD. This study investigated whether proteins in bulk exosomes can aid in the diagnosis of AD.MethodsThe plasma exosomes were collected by ultracentrifuge. Protein samples were extracted from exosomes. Cerebrospinal fluid levels of amyloid β (Aβ)42 and phosphorylated tau (P-tau)181 were measured for diagnostic purposes. A pilot study (controls, 20; AD, 20) followed by a second dataset (controls, 56; AD, 58) was used to establish a diagnostic model of AD. Mass spectrometry-based proteomics was performed to profile the plasma exosomal proteome. Parallel reaction monitoring was used to further confirm the differentially expressed proteins.ResultsIn total, 328 proteins in plasma exosomes were quantified. Among them, 31 proteins were altered in AD patients, and 12 were validated. The receiver operating characteristic curve analysis revealed a combination of six proteins (upregulated: Ig-like domain-containing protein (A0A0G2JRQ6), complement C1q subcomponent subunit C (C1QC), complement component C9 (CO9), platelet glycoprotein Ib beta chain (GP1BB), Ras suppressor protein 1 (RSU1); downregulated: disintegrin and metalloproteinase domain 10 (ADA10)) has the capacity to differentiate AD patients from healthy controls with high accuracy. Linear correlation analysis showed that the combination was significantly correlated with cognitive performance.ConclusionsThe combination of plasma exosomal proteins A0A0G2JRQ6, C1QC, CO9, GP1BB, RSU1, and ADA10 acts as a novel candidate biomarker to differentiate AD patients from healthy individuals.
Cecal perforations due to descending colon obstruction (closed loop): a case report and review of the literature
Authors: Naiem Mohamed Eltayeb Abdelrahman , Suliman Suliman Hussein 
Published: December 2022

Abstract
Background
Cases of large bowel closed-loop phenomenon with cecal perforation are extremely rare, especially when extracolonic epiploic appendage and peritoneal bands are the cause. However, sporadic cases exist in the literature with various presentations, but very few occur in patients in the abdomen without a previous scar.

Case presentation
An 89-year-old Sudanese farmer was admitted to the emergency department with 9-day history of generalized colicky abdominal pain, abdominal distension, anorexia, persistent vomiting, and constipation. Given his clinical presentation and assessment, he was diagnosed with peritonitis due to a perforated viscus in a virgin abdomen. Operative exploration revealed an extraluminal left-sided omento–epiploic band that resulted in closed-loop colonic obstruction with secondary multiple cecal perforations. Standard right hemicolectomy with adhesiolysis was done. Postoperative wound infection and hypoalbuminemia were treated, and the patient was discharged on postoperative day 9 on a regular oral diet.

Conclusions
Although this condition is rare, it can be extremely dangerous, requiring prompt investigation and surgical intervention. It usually occurs secondary to raised intraluminal pressure with subsequent ischemia of the cecal wall. Through this case report, we aim to reflect on this rare experience, shedding light on the benign, extracolonic pathologies that can be life threatening or even fatal.
Attention mechanism combined with residual recurrent neural network for sound event detection and localization
Authors: Lan Chaofeng , Zhang Lei , Zhang Yuanyuan , Fu Lirong , Sun Chao , Han Yulan , Zhang Meng 
Published: December 2022

AbstractIn the task of sound event detection and localization (SEDL) in a complex environment, the acoustic signals of different events usually have nonlinear superposition, so the detection and localization effect is not good. Given this, this paper is based on the Residual-spatially and channel Squeeze-Excitation (Res-scSE) model. Combined with Multiple-scale Convolutional Recurrent Neural Network (M-CRNN), the Res-scSE-CRNN model is proposed. Firstly, to solve the problem of insufficient extraction of time-frequency feature in single-size convolution kernel, multi-scale feature fusion is carried out by using the feature hierarchy of the convolutional neural network to improve the accuracy of detection. Secondly, aiming at the problem of overlapping audio event localization accuracy is not high, with Res-scSE to replace common convolution module and add residual structure to strengthen the feature extraction, and combining with an attention mechanism to enhance neural network channels and spatial relationships, to improve the network to extract the characteristics of directivity, achieve the goal of the overlapped audio localization. In this paper, experiments are carried out in the open dataset DCASE2019, and evaluation indicators are used to analyze the effectiveness of the proposed model and baseline model in the detection and localization of audio events. The results show that compared with the M-CRNN model, the detection error rate of Res-scSE-CRNN model is reduced 4%, the F1-Score is increased 3.4%, the localization error is reduced by 22.8°, and the frame recall rate is increased 3%.
A critical appraisal of delirium clinical practice guidelines relevant to the care of older adults in the emergency department with a synthesis of recommendations: an umbrella review protocol
Authors: Filiatreault Sarah , Grimshaw Jeremy M. , Kreindler Sara A. , Chochinov Alecs , Linton Janice , Doupe Malcolm B. 
Published: December 2022

Abstract
Background
Up to 35% of older adults present to the emergency department (ED) with delirium or develop the condition during their ED stay. Delirium associated with an ED visit is independently linked to poorer outcomes such as loss of independence, increased length of hospital stay, and mortality. Improving the quality of delirium care for older ED patients is hindered by a lack of knowledge and standards to guide best practice. High-quality clinical practice guidelines (CPGs) have the power to translate the complexity of scientific evidence into recommendations to improve and standardize practice. This study will identify and synthesize recommendations from high-quality delirium CPGs relevant to the care of older ED patients.

Methods
We will conduct a multi-phase umbrella review to retrieve relevant CPGs. Quality of the CPGs and their recommendations will be critically appraised using the Appraisal of Guidelines, Research, and Evaluation (AGREE)-II; and Appraisal of Guidelines Research and Evaluation – Recommendations Excellence (AGREE-REX) instruments, respectively. We will also synthesize and conduct a narrative analysis of high-quality CPG recommendations.

Discussion
This review will be the first known evidence synthesis of delirium CPGs including a critical appraisal and synthesis of recommendations. Recommendations will be categorized according to target population and setting as a means to define the bredth of knowledge in this area. Future research will use consensus building methods to identify which are most relevant to older ED patients.

Trial registration
This study has been registered in the Open Science Framework registries: https://doi.org/10.17605/OSF.IO/TG7S6.
Effectiveness of postoperative oral administration of cephalexin and metronidazole on surgical site infection among obese women undergoing cesarean section: a randomized, double-blind, placebo-controlled, parallel-group study—phase III
Authors: Tara Fatemeh , Danesteh Sina , Rezaee Maral , Geraylow Kiarash Roustai , Moodi Ghalibaf AmirAli , Moeindarbari Somayeh 
Published: December 2022

AbstractBackgroundCesarean section (CS) is the most frequently performed surgery in the United States. Compared to vaginal delivery, CS has a higher risk of maternal and neonatal mortality, morbidities, and complications, among which surgical site infection (SSI) is the most common. We aimed at evaluating the effectiveness of postoperative oral administration of cephalexin and metronidazole on SSI among obese women undergoing CS.MethodsWe conducted a randomized, double-blind clinical trial comparing the prophylactic effect of oral cephalexin and metronidazole vs cephalexin and placebo on SSI following CS among obese women. who had received preoperative prophylactic cephalosporin antibiotics. The study was conducted at the Ommolbanin Hospital, affiliated with Mashhad University of Medical Sciences from April 2019 to February 2020.ResultThe participants were randomized into the intervention group (n = 210) and the control group (n = 210). At week-1 follow-up, the outcomes were significantly lower in the intervention group as compared to the control group in terms of fever (9% vs 19%,p = 0.003), abnormal discharge from the incision (serous: 8.6% vs 10.5%, purulent: 2.9% vs 16.7%,p < 0.001), incision separation (1% vs 7.1%,p = 0.001), and cellulitis (4.8% vs 13.3%,p = 0.002). At week-2 follow-up, there were no patients in the intervention group with fever, abnormal discharge from the incision, incision separation, or cellulitis and there was a statistically significant difference for fever, abnormal discharge from the incision, and incision separation between the two groups (p < 0.001,p = 0.001,p = 0.014, respectively).ConclusionPost-operative administration of cephalexin and metronidazole for 48-h post-cesarean delivery among obese women, in addition to the standard pre-operative prophylaxis, reduced the overall rate of surgical site infection and wound infection symptoms in a 2-week follow-up.Trial registrationThe study protocol was approved by the Iranian Registry of Clinical Trials (IRCTID: IRCT20200608047685N2) on 2021-03-15.
Identification of DNA methylation signatures for hepatocellular carcinoma detection and microvascular invasion prediction
Authors: Hao Yijie , Yang Qingxia , He Qiye , Hu Huanjing , Weng Zongpeng , Su Zhixi , Chen Shuling , Peng Sui , Kuang Ming , Chen Zhihang , Xu Lixia 
Published: December 2022

AbstractBackground and aimPreoperative evaluation of microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC) is important for surgical strategy determination. We aimed to develop and establish a preoperative predictive model for MVI status based on DNA methylation markers.MethodsA total of 35 HCC tissues and the matched peritumoral normal liver tissues as well as 35 corresponding HCC patients’ plasma samples and 24 healthy plasma samples were used for genome-wide methylation sequencing and subsequent methylation haplotype block (MHB) analysis. Predictive models were constructed based on selected MHB markers and 3-cross validation was used.ResultsWe grouped 35 HCC patients into 2 categories, including the MVI− group with 17 tissue and plasma samples, and MVI + group with 18 tissue and plasma samples. We identified a tissue DNA methylation signature with an AUC of 98.0% and a circulating free DNA (cfDNA) methylation signature with an AUC of 96.0% for HCC detection. Furthermore, we established a tissue DNA methylation signature for MVI status prediction, and achieved an AUC of 85.9%. Based on the MVI status predicted by the DNA methylation signature, the recurrence-free survival (RFS) and overall survival (OS) were significantly better in the predicted MVI− group than that in the predicted MVI + group.ConclusionsIn this study, we identified a cfDNA methylation signature for HCC detection and a tissue DNA methylation signature for MVI status prediction with high accuracy.
Revisiting the electricity consumption-led growth hypothesis: is the rule defied in France?
Authors: Rafindadi Abdulkadir Abdulrashid , Aliyu Isah Buhari , Usman Ojonugwa 
Published: December 2022

AbstractRecent economics literature emphasises the inextricable link between economic prosperity and efficient energy supply and consumption, arguing vehemently that much of today’s prosperity is predicated on secure and reliable energy use and that modern industry would grind to a halt without the necessary energy infrastructure. France is an example of an advanced country with enormous energy infrastructure. The country’s economic growth has been rather sluggish in recent years, despite its robust and efficient energy production and consumption. The current study analyses empirically whether France’s current sustainable electricity use defies the theoretical and empirical literature. To achieve this objective, the standard tools of growth empirics were used over the period 1961–2015. The Zivot–Andrews trended and de-trended structural break tests, as well as Autoregressive Distributed lag (ARDL) bounds testing were employed to analyse the data. The findings of this study demonstrated that France's economic growth is stimulated by electricity usage, financial development, capital, import, and export. The study sheds light on the feedback impact between economic growth and power usage as well as capital and economic growth. With these findings, we argue that it is not electricity that has ceased to serve a functional purpose in France, rather there is a need for entrepreneurial innovative capacity to create factors that require an infinite horizon for the continued use of electricity, which seems to be impeding the country's economic growth potential, among other things.
Carbohydrate malabsorption in anorexia nervosa: a systematic review
Authors: Buck Patrizia , Joli Jian , Zipfel Stephan , Stengel Andreas 
Published: December 2022

Abstract
Objectives
Anorexia nervosa (AN) is an eating disorder accompanied by a low body mass index and (self-) restricted food intake. Nutritional limitations can cause complaints of the digestive system, because of a disturbed absorption of food components. The absorption of carbohydrates may be seriously affected and reduced to a minimum. On this basis, a possible connection between AN, and the prevalence of gastrointestinal symptoms due to malabsorption was examined.

Methods
For the systematic literature research with the aim of a better understanding of the topic the databases PubMed, Web of Science, Cochrane Library, Livivo and Google Scholar were used.

Results
After the manual selection process of 2215 retrieved studies, 89 full texts were read and according to the predetermined eligibility criteria, finally 2 studies on the monosaccharide fructose and disaccharide lactose were included in this review.

Conclusion
Malabsorption is often observed in patients with AN. It may contribute to the gastrointestinal complaints reported by patients and hamper body weight regain. Among others, mucosal atrophy and duodenal transporter dysfunction are discussed as main reasons. In the future more studies on carbohydrate malabsorption related to low body weight as observed in AN are warranted and may be conducted rather in an outpatient setting.
Bleaching cotton in textile conservation: a closer look using atomic force microscopy
Authors: Salem Rana T. A. , Thompson Karen , Uttamlal Mahesh 
Published: December 2022

Abstract
Aqueous bleaching may be used in textile conservation to improve the appearance of historic and culturally significant textiles. It is generally accepted amongst conservators that bleaching imparts damage. The aim of this research is to characterise the condition of cotton fibre's surface pre- and post-bleaching using atomic force microscopy (AFM). Unprocessed cotton calico (‘raw’ cotton), scoured cotton, and a historic cotton dress shirt (circa. 1920) were bleached using three separate methods: NaBH4 for 15 min; H2O2/NaBO3 for 1 h; and H2O2/NaBO3 buffered to pH 8.4 for 1 h. AFM was used in tapping-mode to obtain height, amplitude, and phase images. AFM imaging was able to distinguish between the cuticle, primary walls, and secondary walls of the cotton fibres. The data shows that bleaching has the effect of softening and removing individual layers of the cotton structure. Unprocessed cotton calico and scoured cotton fared better against the impact of bleaching. This was in stark contrast to the historic shirt where the already damaged surface of cotton fibres underwent further degradation using both oxidative and reductive bleaching. In general, reductive bleaching was more aggressive on the fibre surface compared to oxidative bleaching. The use of AFM provides further evidence of the physical effects of bleaching on historic textiles, and cotton textiles more broadly, and it has the potential to influence the conservator’s decision-making.
Adaptive learning: toward an intentional model for learning process guidance based on learner’s motivation
Authors: Bayounes Walid , Saâdi Ines Bayoudh , Kinshuk  
Published: December 2022

AbstractThe goal of ITS is to support learning content, activities, and resources, adapted to the specific needs of the individual learner and influenced by learner’s motivation. One of the major challenges to the mainstream adoption of adaptive learning is the complexity and time involved in guiding the learning process. To tackle these problems, this research proposes an intentional model that adopts Map formalism to support personalized learning guidance by considering learner’s motivation. For that, the intentional model adopts the ARCS model of motivation. The proposed model couples the learner’s intention with the learning strategies and provides a multitude of paths between learner intentions. Based on the learner’s motivation and the corresponding learning mode or the individual learning style, the ITS can adaptively support the learner to achieve his/her intention through the selected strategy. The first results show that this study’s provide implications for both theoretical research and the practical development of ITSs that will help education professionals make full use of ITSs. In the initial tests, the process model has met what was expected, however, more studies with experiments must be carried out.
A decellularized and sterilized human meniscus allograft for off-the-shelf meniscus replacement
Authors: Spierings Janne , Velthuijs Wietske , Mansoor Amal , Bertrand Manon E. , Uquillas Jorge Alfredo , Ito Keita , Janssen Rob P. A. , Foolen Jasper 
Published: December 2022

Abstract
Purpose
Meniscus tears are one of the most frequent orthopedic knee injuries, which are currently often treated performing meniscectomy. Clinical concerns comprise progressive degeneration of the meniscus tissue, a change in knee biomechanics, and an early onset of osteoarthritis. To overcome these problems, meniscal transplant surgery can be performed. However, adequate meniscal replacements remain to be a great challenge. In this research, we propose the use of a decellularized and sterilized human meniscus allograft as meniscal replacement.

Methods
Human menisci were subjected to a decellularization protocol combined with sterilization using supercritical carbon dioxide (scCO2). The decellularization efficiency of human meniscus tissue was evaluated via DNA quantification and Hematoxylin & Eosin (H&E) and DAPI staining. The mechanical properties of native, decellularized, and decellularized + sterilized meniscus tissue were evaluated, and its composition was determined via collagen and glycosaminoglycan (GAG) quantification, and a collagen and GAG stain. Additionally, cytocompatibility was determined in vitro.

Results
Human menisci were decellularized to DNA levels of ~ 20 ng/mg of tissue dry weight. The mechanical properties and composition of human meniscus were not significantly affected by decellularization and sterilization. Histologically, the decellularized and sterilized meniscus tissue had maintained its collagen and glycosaminoglycan structure and distribution. Besides, the processed tissues were not cytotoxic to seeded human dermal fibroblasts in vitro.

Conclusions
Human meniscus tissue was successfully decellularized, while maintaining biomechanical, structural, and compositional properties, without signs of in vitro cytotoxicity. The ease at which human meniscus tissue can be efficiently decellularized, while maintaining its native properties, paves the way towards clinical use.
What factors encourage the acceptance of cosmetic surgery? Differences in sociopsychological influences contingent upon cosmetic surgery experience
Authors: Kim Sunwoo 
Published: December 2022

AbstractWhile numerous sociopsychological factors affect one’s acceptance of cosmetic surgery, little is known about the sociopsychological influences that lead to cosmetic surgery acceptance based on one’s prior experience with cosmetic surgery. The present study identified the differences between two groups: women with cosmetic surgery experience and women without prior cosmetic surgery experience. A research model was developed with five hypotheses to identify the four sociopsychological influences on cosmetic surgery acceptance: upward appearance comparison, awareness of an emphasis on beauty ideals, internalization of beauty ideals, and body surveillance. Data were collected from 651 South Korean women in their 20 s to 40 s and were analyzed using second-order confirmatory factor analysis and multi-group structural equation modeling. In the cosmetic surgery group, upward appearance comparison, awareness of an emphasis on beauty ideals, and body surveillance had a positive effect on cosmetic surgery acceptance. Internalization of beauty ideals and body surveillance also had a positive effect on cosmetic surgery acceptance in the no cosmetic surgery group. Additionally, the effects of upward appearance comparison, awareness of an emphasis on beauty ideals, and internalization of beauty ideals on cosmetic surgery acceptance varied significantly between the two groups. The findings add insights on the design of therapeutic programs to prevent cosmetic surgery addiction and education programs to increase body appreciation.