bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imidazole-amino acids. Conformational switch under tautomer and pH change
Authors: Staś Monika , Najgebauer Piotr , Siodłak Dawid 
Published: November 2022

AbstractReplacement of the main chain peptide bond by imidazole ring seems to be a promising tool for the peptide-based drug design, due to the specific prototropic tautomeric as well as amphoteric properties. In this study, we present that both tautomer and pH change can cause a conformational switch of the studied residues of alanine (1–4) and dehydroalanine (5–8) with the C-terminal peptide group replaced by imidazole. The DFT methods are applied and an environment of increasing polarity is simulated. The conformational maps (Ramachandram diagrams) are presented and the stability of possible conformations is discussed. The neutral forms, tautomers τ (1) and π (2), adapt the conformations αRτ (φ, ψ = − 75°, − 114°) and C7eq (φ, ψ = − 75°, 66°), respectively. Their torsion angles ψ differ by about 180°, which results in a considerable impact on the peptide chain conformation. The cation form (3) adapts both these conformations, whereas the anion analogue (4) prefers the conformations C5 (φ, ψ = − 165°, − 178°) and β2 (φ, ψ ~ − 165°, − 3°). Dehydroamino acid analogues, the tautomers τ (5) and π (6) as well as the anion form (8), have a strong tendency toward the conformations β2 (φ, ψ = − 179°, 0°) and C5 (φ, ψ = − 180°, 180°). The preferences of the protonated imidazolium form (7) depend on the environment. The imidazole ring, acting as a donor or acceptor of the hydrogen bonds created within the studied residues, has a profound effect on the type of conformation.
Human capital and the intertemporal substitution for leisure: empirical evidence for Spain
Authors: Cutanda Antonio , Sanchis-Llopis Juan A. 
Published: November 2022

AbstractIn this paper we provide the first estimate of the intertemporal substitution for leisure in Spain, accounting for the impact of human capital accumulation. This would allow uncovering whether the intertemporal labour supply of Spanish workers is affected by human capital. Our empirical strategy consists of estimating the equation for the intertemporal substitution of leisure with and without accounting for human capital, what allows to detect hypothetical estimation biases associated to omitting the impact of human capital. To that end, we build a pseudo-panel data set combining the Spanish Family Expenditure Survey and the Labour Survey over the period 1987–1997. While the model that ignores human capital accumulation provides an estimate of the intertemporal elasticity of substitution for leisure about 0.25, comparable to previously available estimates for Spain and other economies, the model with human capital provides an estimate about 0.5, what confirms the existence of a bias in the former estimates. Finally, this bias is larger for the younger cohorts than for the older ones.
On Why Quine’s Ontological Relativity Requires Reconsideration
Authors: Król Zbigniew , Lubacz Józef 
Published: November 2022

AbstractWe aim to show from a new perspective that Quine’s ontological relativity, based largely on his so-called “proxy-function argument”, falls short of being a rigorously coherent philosophical conception, as it exhibits significant formal defects. This new perspective enables exposing the shortcomings of Quine's position and suggests a possible reformulation of the original position. Moreover, we argue that his ontological relativity is inconsistent with the empirical data associated with some of our best physical theories, such as quantum mechanics. We refer to fundamental concepts of philosophy and the foundations of mathematics in order to clarify our critique of Quine’s position concerning the relation between formalized theories and both what we can know about the real world and how we come to know it.
Connecting academics’ disciplinary knowledge to their professional development as university teachers: a conceptual analysis of teacher expertise and teacher knowledge
Authors: van Dijk Esther E. , Geertsema Johan , van der Schaaf Marieke F. , van Tartwijk Jan , Kluijtmans Manon 
Published: November 2022

AbstractDisciplinary knowledge lies at the heart of academic work. However, connecting academics’ disciplinary knowledge to their professional development as teachers has been a longstanding challenge for (research-intensive) universities. This is reflected in criticism of the practices that aim to support the professional development of university teachers. In order to create better connections, a deeper understanding is needed of how academics’ disciplinary knowledge relates to the development of their teaching. In this paper, we therefore aim to advance theoretical insights about how academics’ disciplinary knowledge connects to their professional development as university teachers. We do so by providing a conceptual analysis of teacher expertise and teacher knowledge perspectives. Literature discussed as part of the teacher expertise perspective provides insights into how knowledge is structured in order to perform teacher tasks. In our discussion of the teacher knowledge perspective, we include bodies of literature about teachers’ knowledge base to explore the role of disciplinary knowledge in how to teach and about powerful knowledge to explore the role of disciplinary knowledge in what to teach. Insights from these bodies of literature can, from a teacher knowledge perspective, offer theoretical underpinnings for connecting academics’ disciplinary knowledge to their professional development as university teachers. Adaptive expertise and practical knowledge are identified as concepts that include elements of both teacher expertise and teacher knowledge perspectives. Based on the conceptual analysis, we identify and discuss three aspects related to supporting the professional development of university teachers where attention to connection with teachers’ disciplinary knowledge is important.
An Examination of the Negative Occupancy Distribution and the Coupon-Collector Distribution
Authors: O’Neill Ben 
Published: November 2022

AbstractWe examine the negative occupancy distribution and the coupon-collector distribution, both of which arise as distributions relating to hitting times in the extended occupancy problem. These distributions constitute a full solution to a generalised version of the coupon collector problem, by describing the behaviour of the number of items we need to collect to obtain a full collection or a partial collection of any size. We examine the properties of these distributions and show how they can be computed and approximated. We give some practical guidance on the feasibility of computing large blocks of values from the distributions, and when approximation is required.
Why does the confidence in companies, but not the confidence in the government, affect the demand for regulation differently across countries?
Authors: Czeglédi Pál 
Published: November 2022

AbstractIn an attempt to contribute to the literature on how and why confidence in market participants and in the government shape the demand for market regulation, this paper contrasts two interpretations. The interpretation implicit in the empirical literature supposes that people trade off market failures for government failures. The paper argues that implicit in the broader public choice literature there is an alternative that emphasizes the nirvana fallacy and leads to the conclusion that people’s views on markets and government in general is a determinant of the effect of trust on the demand for regulation. The paper applies a meta-regression analysis to examine the results of country-level regressions with different survey waves of the Integrated Values Surveys. It shows that the effect of the two kinds of trust are asymmetric and that the negative effect of the confidence in companies on the demand for government regulation is larger in countries that score higher on individualism.
Who are the In-Work Poor? A Study of the Profile and Income Mobility Among the In-Work Poor in Sweden from 1987 to 2016
Authors: Broström Lovisa , Jansson Birgitta 
Published: November 2022

AbstractWe studied the development, profile, and income mobility among individuals in in-work poverty in Sweden over a period of 30 years using data covering the entire population on a yearly basis from 1987 to 2016. By introducing a more solid work requirement that stretches over more time than the frequently used ‘seven-month rule’, we make sure that the in-work poor person in our study is mainly working. Our results show that the profile has changed: in 1987, the typical in-work poor person was a native-born single woman, but in 2016, they were a married man born outside of Sweden. When modelling income mobility over two 5-year periods, our results show that changes in household composition explain both upward and downward mobility and that it has become harder to change income position. Interpreting the results on a structural level, two conclusions can be drawn. As in-work poverty is no longer female-dominated, the Swedish policy for gender equality has been successful. As it is now closely connected with immigration status, the integration of immigrants into the labour market must improve.
Digitalization of the Logistics Process in Short Food Supply Chains. An online Viable System Model application during the COVID-19 pandemic
Authors: Vilalta-Perdomo Eliseo , Salinas-Navarro David E. , Michel-Villarreal Rosario , García Bustamante Rocío 
Published: November 2022

AbstractThis paper reports an ongoing exercise concerning the design of a logistics App to support operations within Farmers’ Markets in Mexico. This exercise is part of a wider research agenda focused on ‘Supporting Alternative Food Networks’ (SAFeNET). This is a research agenda to conceive, build, implement, and develop better-informing decision-making processes that support effective and efficient AFNs (also known as Short Food Supply Chains) logistics operations in a digital environment, through smooth flows of goods and information among producers, AFNs coordinators, and consumers. This view calls for taking a systemic approach to help collectives of people to improve their autonomy and viability. Initial plans were to conduct this collaborative design exercise, using the Viable System Model (VSM) as a conversational tool. Accordingly, a series of face-to-face interviews and a focus group were planned. However, the lockdown due to COVID-19 forced researchers to abandon the face-to-face option and conduct the primary data collection online. The VSM intervention had to be adapted for its use on an online platform, in such a way that the platform would support knowledge building interactively, with a series of participants. This paper describes the format and visual appearance of the online VSM framework, its application, and the lessons learned through this exercise. Two points deserve to be highlighted: First, although the exercise outcome was very valuable for the next stage of the design, the participants’ capacity for collective and individual reflection during the workshop was limited. Second, participants continued adding comments via the adopted online visual collaboration platform after the workshop ended, showing an understanding of the process and commitment beyond the researchers’ expectations. The outcomes from this experiment are promissory, suggesting that online Systems Thinking interventions deserve further development.
Diverse forms of xylem-Like cells and strand formation in Xylogenic Eucalyptus bosistoana callus culture
Authors: Shwe Sabai Saw , Alizadeh Hossein , Tayagui Ayelen , Leung David W. M. 
Published: November 2022

AbstractIn vitro xylem induction system is a basic tool in physiological, biochemical, and molecular studies of secondary cell wall formation, lignin biosynthesis and deposition associated with tracheary element formation. Eucalyptus bosistoana is a Class 1 durable hardwood tree species, selected by the New Zealand Dryland Forest Initiative for good quality wood and high adaptability to the NZ growing conditions. Xylogenic E. bosistoana callus culture was established and up to 40% of the callus cells were xylem-like cells (XLCs) which may have differentiated from small, cytoplasmically dense or compact dividing, and exhibited increased lignin contents during culture. The eucalyptus XLCs showed diverse sizes, patterns of secondary cell wall thickenings similar to the xylem cells in the young shoots and organized development including cell–cell connections of the XLCs to form xylem strands. This is the first report of the organized development of XLCs in E. bosistoana callus culture.
Exploring the antecedents of customers’ willingness to use service robots in restaurants
Authors: Molinillo Sebastian , Rejón-Guardia Francisco , Anaya-Sánchez Rafael 
Published: November 2022

AbstractThis study examines the willingness of customers to accept, and their intention to recommend, the services provided by service robots in restaurants. A mixed-methods research approach was taken to evaluate a theoretical model based on behavioural reasoning theory (BRT). The results demonstrated the important influence of positive attitudes and objections to the use of service robots on consumers’ willingness to use service robots, as well as their intention to recommend restaurants that use them. Among the main aspects that affect attitudes and objections, we found hedonic perceptions, perceived safety, interaction quality perception and anthropomorphism.
Parametric assessment of groundwater vulnerability to pollution within an open pit reclaimed by gangue
Authors: Niedbalska Katarzyna 
Published: November 2022

AbstractThe use of post-mining wastes in the reclamation of an open pit may act as a source of pollution that has a very strong impact on the groundwater environment. One such facility in Poland is the CTL Maczki-Bór S.A. sand mine filled with waste rock from hard coal mines. The current hydrodynamic conditions in the Quaternary aquifer causes that the wastes are in the bottom part of the open pit under the constant influence of groundwater. Due to the sub-level nature of the pollution source, the author of the study modified the classic rank-weight method of assessing the groundwater vulnerability to pollution in order to adapt it to the atypical type of the pollutant emitter. An individual approach was proposed by modifying the range of parameters as well as the assigned ranks and weights. Six key parameters were indicated, i.e. the thickness of the aeration zone, the thickness of the saturation zone, the filtration coefficients of the deposits in both of these zones, the recharge of the aquifer and the surface topography. The correctness of weight selection was verified by sensitivity analysis in the sensitivity variant of one parameter. It has been proposed to classify the groundwater vulnerability to 5 classes from moderately high to extremely high. For theoretical and effective weights, the obtained values of the index of groundwater vulnerability to pollution allowed to divide the area of the reclaimed open pit into two zones with high and very high groundwater vulnerability to pollution.
Microeconomic adaptation to severe climate disturbances on Australian coral reefs
Authors: Bartelet Henry A. , Barnes Michele L. , Cumming Graeme S. 
Published: November 2022

AbstractCoral reefs are increasingly affected by climate-induced disturbances that are magnified by increasing ocean temperatures. Loss of coral reefs strongly affects people whose livelihoods and wellbeing depend on the ecosystem services reefs provide. Yet the effects of coral loss and the capacity of people and businesses to adapt to it are poorly understood, particularly in the private sector. To address this gap, we surveyed about half (57 of 109) of Australian reef tourism operators to understand how they were affected by and responded to severe impacts from bleaching and cyclones. Reef restoration and spatial diversification were the primary responses to severe bleaching impacts, while for cyclone-impacts coping measures and product diversification were more important. Restoration responses were strongly linked to the severity of impacts. Our findings provide empirical support for the importance of response diversity, spatial heterogeneity, and learning for social-ecological resilience.
Rapid re-establishment of top-down control at a no-take artificial reef
Authors: Kraufvelin Patrik , Bergström Lena , Sundqvist Frida , Ulmestrand Mats , Wennhage Håkan , Wikström Andreas , Bergström Ulf 
Published: November 2022

AbstractEstablishment of artificial reefs and no-take areas are management measures available for restoring deteriorated marine ecosystems, compensating for habitat loss and strengthening harvested populations. Following the establishment of no-take artificial reefs in western Sweden to compensate for hard bottoms lost to a shipping lane, we detected rapid positive effects on crustaceans and demersal fish compared to fished reference areas. The relative abundance and size structure of European lobster (Homarus gammarus) increased strongly in the no-take area indicating more than doubled and tripled egg production in 5 and 10 years, respectively. For benthic fish and crustacean communities, the abundances of gadoids and wrasses increased and the abundances of small decapod crustaceans decreased in the no-take area, likely indicating cascading effects of increased predation. The study demonstrates that relatively small no-take areas, enhanced by artificial reefs, can rapidly invigorate populations of lobster and fish that in turn may re-initiate local top-down control.
Die MISSCARE-Austria-Studie – Teil III
Authors: Cartaxo Ana , Eberl Inge , Mayer Hanna 
Published: November 2022

ZusammenfassungHintergrundPflegepersonen auf Allgemeinstationen im Krankenhaus arbeiten unter belastenden Arbeitsbedingungen und mit knappen Ressourcen. Der Pflegepersonalmangel im akutstationären Bereich stellt bereits jetzt eine Gefährdung für die Aufrechterhaltung der Patient*innenversorgung dar. Das Pflegepersonal berichtet darüber, dass notwendige Maßnahmen in der Patient*innenversorgung aufgrund knapper Ressourcen weggelassen werden müssen. Dieses Phänomen wird alsMissed Nursing Carebezeichnet. Die sich daraus ergebende Situation wird in der Literatur als erheblicher Faktor für die berufsbezogene Zufriedenheit von Pflegepersonen und für die Absicht, den Pflegeberuf zu verlassen, beschrieben.ZieleDie derzeitige berufliche Zufriedenheit und die Absicht, den Pflegeberuf zu verlassen, von Pflegepersonen auf Allgemeinstationen im akuten Bereich zu untersuchen. Insbesondere sollen unter Berücksichtigung der Arbeitssituation und des Phänomens vonMissed Nursing CareAspekte aufgedeckt werden, die einen Einfluss auf die Absicht, den Pflegeberuf zu verlassen, ausüben können.MethodeDie MISSCARE-Austria-Studie ist eine quantitative Querschnittstudie mittels Online-Fragebogenerhebung mit dem revised MISSCARE-Austria. Die Analyse erfolgt mittels deskriptiver Statistik sowie Korrelationskoeffizienten, nichtparametrischen Gruppenvergleichstests und logistischer Regressionsanalyse. Teilnehmer*innen sind Pflegepersonen auf Allgemeinstationen in österreichischen Krankenhäusern.ErgebnisseAn der Studie haben 1006 Pflegepersonen teilgenommen. Der Großteil der Befragten arbeitet in Vollzeit, in wechselnden Diensten und mehr als 10 h/Dienst. 80 % überschritten ihre geplanten Arbeitsstunden innerhalb der letzten 3 Monate. Es wurde eine positive Tendenz zur Arbeitszufriedenheit beobachtet, wobei jedoch ca. 75 % der Befragten in unterschiedlichen Zeitabständen darüber nachdenken, aus dem Pflegeberuf auszusteigen. Ein hochsignifikanter Zusammenhang zwischenMissed Nursing Careund den beiden VariablenArbeitszufriedenheitundAbsicht, den Pflegeberuf zu verlassen, wurde festgestellt. Wichtige Einflussfaktoren auf die Absicht, den Pflegeberuf zu verlassen, waren das Alter (OR = 1,57), die Funktion als diplomiertes Pflegepersonal (OR = 2,83), Überstunden bei Pflegepersonen ohne wechselnde Dienstzeiten (OR = 1,04), Arbeitszufriedenheit (OR = 0,04) sowieMissed Nursing Care(OR = 1,56).SchlussfolgerungMissed Nursing Careist ein wichtiger Prädiktor für die Arbeitszufriedenheit und für die Absicht von Pflegepersonen, den Beruf zu verlassen. Unsere Studie bestärkt die Relevanz des weiteren Monitorings dieses Phänomens in der österreichischen Versorgungslandschaft angesichts der aktuell prekären Pflegepersonalsituation, um aktuelle Entscheidungen in der Pflegepolitik zu unterstützen.
Cognitive trajectories preluding the imminent onset of Alzheimer’s disease dementia in individuals with normal cognition: results from the HELIAD cohort
Authors: Liampas Ioannis , Siokas Vasileios , Ntanasi Eva , Kosmidis Mary H. , Yannakoulia Mary , Sakka Paraskevi , Hadjigeorgiou Georgios M. , Scarmeas Nikolaos , Dardiotis Efthimios 
Published: November 2022

Abstract
Background
The cognitive trajectories of cognitively normal (CN) individuals rapidly progressing to Alzheimer’s disease dementia (AD) have not been investigated.

Aim
To explore the preclinical pattern of cognitive performance heralding the rapid progression from normal cognition to AD.

Methods
The HELIAD cohort underwent comprehensive neuropsychological assessments (memory, language, attention, executive and visuo-perceptual functions) at baseline and after approximately 3-year intervals. The cognitive trajectories of those with normal cognition at baseline were explored according to the follow-up diagnosis using adjusted generalised estimating equations analyses.

Results
A total of 932 predominantly female (61%), older (72.9 ± 4.9), CN participants were followed for 3.09 (± 0.83) years. Among them, 761 individuals remained CN, 29 progressed to AD and 142 developed MCI (33 single-domain amnestic, 41 multidomain amnestic, 37 single-domain non-amnestic and 31 multidomain non-amnestic). Those progressing to AD were already performing worse than the healthy reference in every single cognitive domain at baseline. Cognitive deficits ranged between ~ 0.5SD (attention, executive function and language) and ~ 1.0SD (memory and visuo-perceptual skills). Throughout the 3-year follow-up, memory constantly exhibited the most prominent impairment compared to the remaining cognitive domains while executive function diminished in the most abrupt fashion (~ 0.19SD yearly) separating from the remaining three cognitive functions before the development of full-blown AD. Heterogeneous patterns of cognitive decline clearly differentiated those progressing to MCI from those rapidly converting to AD, as well.

Discussion
Poor performance in every cognitive domain may characterise cognitively normal individuals at high risk of fast progression to AD.

Conclusion
Strict neuropsychological cut-offs fail to detect a considerable number of individuals at high risk of rapid progression to AD.