bluuebunny/crossref_metadata_2025_split huggingface dataset:
Price Transparency for Primary Care Office Visits and Routine Tests: Results From a 2016 Audit Study
Authors: Batra Anchita , Candon Molly 
Published: April 2022

Introduction: Price transparency is a central component of the shift from volume to value in healthcare delivery. Price transparency in primary care, the most common point of contact with the healthcare system for patients in the U.S., has not been widely studied. Methods: Using an audit study across 10 states in 2016, we examined the characteristics of primary care practices that were able to provide price information for office visits and routine tests. Results: Most primary care practices were able to disclose some price information for office visits and routine tests. Results indicate that larger, integrated primary care practices in urban areas and in areas with a higher percentage of minority residents were less likely to provide prices than smaller, standalone practices. Conclusion: These findings suggest that future efforts to increase price transparency in primary care should be tailored to practice characteristics, including practice location and whether the practice is embedded in an integrated health system.
LINC00936 exacerbated myocardial infarction progression via miR-4795-3p/Wnt3a signaling pathway based on biological and imaging methods
Authors: Xu Lvyun , Wang Fan 
Published: April 2022

Objective LncRNAs show great potential in diagnosing and treating myocardial infarction (MI). Clarifying the mechanism of lncRNAs on MI is of great significance for the application of MI biomarkers. Therefore, this report intended to determine the role and mechanism of LINC00936 on MI by biological and imaging methods. Methods Hypoxia H9C2 model was established by hypoxia treatment. Flow cytometry and terminal deoxynucleotidyl transferase dUTP nick end labeling assay detected the apoptosis of H9C2. H2DCFDA staining and enzyme-linked immunosorbent assay (ELISA) was used to detect the reactive oxygen species (ROS) accumulation and Lactate dehydrogenase (LDH) contents, respectively. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to detect LINC00936, Wnt3a and miR-4795-3p levels. Western blot detected Wnt3a protein expression. Dual luciferase reporter assays detected the relationship of miR-4795-3p to LINC00936 or Wnt3a. Echocardiography analysis detected cardiac function. 2,3,5-Triphenyltetrazolium chloride (TTC) detected the infarct size. Masson staining detected the pathological changes. Results LINC00936 level was elevated in the MI patients compared with the controls. Overexpression of LINC00936 promoted apoptosis and ROS accumulation in hypoxia H9C2 model and exacerbated MI progression in vivo. miR-4795-3p bound with LINC00936 in H9C2 cells and miR-4795-3p mimics inhibited apoptosis and ROS accumulation in hypoxia H9C2 model regulated by LINC00936. Wnt3a was targeted by miR-4795-3p and Wnt3a elevation promoted apoptosis and ROS accumulation in hypoxia H9C2 model. Conclusion In this report, we illustrated that LINC00936 exacerbated MI progression via the miR-4795-3p/Wnt3a signaling pathway based on biological and imaging methods. These findings might provide potential molecular target for the diagnosis and treatment of MI.
Communications to Promote Interest and Confidence in COVID-19 Vaccines
Authors: Thorpe Alistair , Fagerlin Angela , Drews Frank A. , Butler Jorie , Stevens Vanessa , Riddoch Marian S. , Scherer Laura D. 
Published: April 2022

Purpose Communicating about COVID-19 vaccine side effects and efficacy is crucial for promoting transparency and informed decision-making, but there is limited evidence on how to do so effectively. Design A within-subjects experiment. Setting Online survey from January 21 to February 6, 2021. Subjects 596 US Veterans and 447 non-Veterans. Intervention 5 messages about COVID-19 vaccine side effects and 4 messages about COVID-19 vaccine efficacy. Measures COVID-19 vaccine interest (1 = “I definitely do NOT want the vaccine” to 7 = “I definitely WANT the vaccine” with the midpoint 4 = “Unsure”). Confidence about COVID-19 vaccine efficacy (1= “Not at all confident,” 2 = “Slightly confident,” 3 = “Somewhat confident,” 4 = “Moderately confident,” 5 = “Extremely confident”). Results Compared to providing information about side effects alone ( M = 5.62 [1.87]), messages with additional information on the benefits of vaccination (M = 5.77 [1.82], P < .001, dz = .25), reframing the likelihood of side effects (M = 5.74 [1.84], P < .001, dz = .23), and emphasizing that post-vaccine symptoms indicate the vaccine is working (M = 5.72 [1.84], P < .001, dz = .17) increased vaccine interest. Compared to a vaccine efficacy message containing verbal uncertainty and an efficacy range ( M = 3.97 [1.25]), messages conveying verbal certainty with an efficacy range ( M = 4.00 [1.24], P = .042, dz=.08), verbal uncertainty focused on the upper efficacy limit ( M = 4.03 [1.26], P < .001, dz = .13), and communicating the point estimate with certainty ( M = 4.02 [1.25], P < .001, dz = .11) increased confidence. Overall, Veteran respondents were more interested ( M Veterans = 5.87 [1.72] vs M NonVeterans = 5.45 [2.00], P < .001, d = .22) and confident ( M Veterans = 4.13 [1.19] vs M NonVeterans = 3.84 [1.32], P < .001, d = .23) about COVID-19 vaccines than non-Veterans. Conclusions These strategies can be implemented in large-scale communications (e.g., webpages, social media, and leaflets/posters) and can help guide healthcare professionals when discussing vaccinations in clinics to promote interest and confidence in COVID-19 vaccines.
Food Insecurity and Mental Well-Being Among Low-Income Families During COVID-19 Pandemic
Authors: Ling Jiying , Duren Paige , Robbins Lorraine B. 
Published: April 2022

Purpose To examine the interaction effects of adult and child food insecurity on parents’ and children’s mental well-being. Design An online survey study was conducted. Setting Two Head Start organizations and the Qualtrics Panel. Subjects Four hundred and eight parents under poverty level and having a child aged 3–5 years participated. Measures Food insecurity was assessed by the U.S. Household Food Security Survey Module. Parents’ stress, anxiety and depression; and children’s sadness, fear, anger, and positive affect were measured using instruments from HealthMeasures. Analysis Multivariate general linear models were performed in SPSS. Results Mean age was 31 years, 17% Hispanic, 21% Black. About 51% parents and 37% children were food insecure. After adjusting for demographics and child food insecurity, parents with adult food insecurity had higher stress ( B = 2.65, p = .002), anxiety ( B = 3.02, p = .001), and depression ( B = 3.66, p = .001); and fear in their children ( B = 5.03, p = .002) than those without adult food insecurity. Similarly, parents reporting child food insecurity had greater depression than those having no child food insecurity ( B = 4.61, p = .020). Black parents had lower stress ( B = −1.91, p = .018), anxiety ( B = −2.26, p = .012), and depression ( B = −4.17, p < .001) than their White counterparts. Conclusions The study’s results underscore the importance of reducing food insecurity in both parents and children as a whole family system to promote mental well-being of low-income families.
Longitudinal Cohort Study of Depression and Anxiety Among Older Informal Caregivers Following the Initial COVID-19 Pandemic Response in Aotearoa New Zealand
Authors: Allen Joanne , Uekusa Shinya , Alpass Fiona M. 
Published: April 2022

Objectives To assess the impact of providing care and conditions of care on psychological wellbeing among older informal caregivers following the initial period of COVID-19 pandemic restrictions in Aotearoa New Zealand. Methods Data were from population-based cohorts of older adults participating in the 2020 Health, Work and Retirement longitudinal survey ( n = 3839, 17.4% informal caregivers). Changes in symptoms of depression and anxiety over 2018–2020 surveys associated with sociodemographic factors, caregiving, cohabitation with the care recipient, assistance provided with activities of daily living, support in providing care, and opportunity cost of care were assessed. Results Increased depression, but not anxiety, was associated with providing informal care. Among caregivers, lower living standards and cohabitation were associated with increased depression. Lower living standards, unemployment, and lower help from friend/family networks were associated with increased anxiety. Discussion Economic hardship and social capital provide targets for supporting psychological wellbeing of older caregivers during periods of pandemic restrictions.
Psychological disorders in patients with orthopaedic oncological diseases and their coping strategies
Authors: Weng Hong Chung , Ajit Singh Vivek , Amar Singh Amarpreet Kaur 
Published: April 2022

Background This study aimed to determine the prevalence and risk factors of anxiety and depression among orthopaedic oncology patients, their quality of life and coping strategies. Methods This cross-sectional study recruited patients from the outpatient orthopaedic oncology clinic at a tertiary institution. Data were collected from self-report questionnaires: Hospital Anxiety and Depression Scale Hospital Anxiety Depression Scale, World Health Organization Quality of Life (WHOQOL-BREF) and Brief Coping with Problems Experienced (Brief COPE). Risk factors were analyzed with multiple logistic regression. Results 191 patients were recruited. The median age was 39.4 years old (IQR 35.0). 29.8% had anxiety, 16.2% had depression, and 15.2% had mixed anxiety and depression. Quality of life median scores differed significantly between patients with anxiety and no anxiety and patients with depression and no depression ( p < 0.001). Patients with mixed anxiety and depression had a more inferior quality of life ( p < 0.001). Age, psychological health and radiotherapy were inversely associated with anxiety. Physical and psychological health were significantly associated with less depression. Ongoing chemotherapy was significantly associated with anxiety and depression. The commonest coping strategies were denial, behavioural disengagement, venting and self-blame. Conclusion Anxiety and depression are prevalent among orthopaedic oncology patients. Patients with mixed anxiety and depression had a more inferior quality of life. Patients with ongoing chemotherapy had higher risks of anxiety and depression. The commonest coping strategies were denial, behavioural disengagement, venting and self-blame. Psychosocial evaluation followed by appropriate psychiatric referrals and consultations could be established to facilitate orthopaedic oncology patients during their course of treatment.
Relationship between oral narrative and vocabulary skills among bilingual language-minority children and their monolingual peers in primary school
Authors: Vettori Giulia , Bigozzi Lucia , Incognito Oriana , Pinto and Giuliana 
Published: April 2022

Aim: This study investigates whether the conditions of bilingual language-minority (BLM) children versus monolingualism have different effects on oral narrative and vocabulary skills in the societal language (SL-Italian) and on the predictive interrelations between the two skills. Methodology: A total of 112 primary school children (44 % BLM L1-Chinese, L2-Italian and 56 % Italian monolinguals) aged 7–11 years ( M age = 113 months, SD = 12.03; 44 girls, 68 boys) performed an oral story-narration task and a vocabulary task. The purpose of the former was to assess the children’s textual (structure, coherence) and language (cohesion, word productivity) competences, while the latter test assessed their ability to define written words by implementing different cognitive-linguistic processes. A parental questionnaire was used to obtain information regarding age, socioeconomic status (SES), and home language exposure. Data analysis: We compared BLM and monolinguals’ lexical competence and oral narrative ability in an independent t-test analysis. We further verified the relationship between the lexical and oral narrative abilities in Spearman bivariate correlations analyses and investigated their interrelations in a stepwise regression model. Age and SES were controlled for. Findings: BLM children fall significantly behind their monolingual peers on textual structure and lexical skills. Meanwhile, their textual and language competences in stories are similar. In the total sample and monolingual group, lexical skills are positively correlated with the text structure. Results of stepwise regression analyses show that lexical skills completely mediate the effect of BLM versus monolingualism on text structure. Originality: Results on school-aged BLM (L1-Chinese, L2-Italian) children’s oral narrative, vocabulary skills, and their relations extend previous research on bilingualism. Significance: The scarce narrative structure in BLM children’s stories is related to limited vocabulary input. High-level textual processing difficulties may result from the high cognitive effort of managing both the choosing of adequate words in L2 and composing an oral story concurrently.
A Blended Cognitive–Behavioral Intervention for the Treatment of Postpartum Depression: A Case Study
Authors: Branquinho Mariana , Canavarro Maria Cristina , Fonseca Ana 
Published: April 2022

Postpartum depression is a highly prevalent mental health problem with harmful consequences for women, babies, and mother–infant relationships. Cognitive–behavioral therapy (CBT) is among the most effective treatment options for postpartum depression. However, a large number of postpartum women do not seek professional help, suggesting the need for new treatment delivery formats. The present article describes the application of Be a Mom Coping with Depression, a blended CBT treatment for postpartum depression, for a 31-year-old postpartum woman. The intervention was provided over a period of 13 weeks, integrating seven biweekly sessions with a psychologist and six sessions within an online program, and it is described in detail. A summary of the patient’s progress and the results obtained throughout treatment is reported. At the end of the intervention, a significant decrease in depressive and anxiety symptoms was observed, as well as increased perceived maternal self-efficacy, higher psychological flexibility, and higher self-compassion. This case study provides encouraging data for the preliminary evidence of the acceptability, feasibility, and efficacy of the Be a Mom Coping with Depression intervention in the reduction of depressive symptoms during the postpartum period. Advantages of this treatment format and implications for clinical practice and future research are discussed.
A phase 1 study of the safety, pharmacokinetics and pharmacodynamics of escalating doses followed by dose expansion of the selective inhibitor of nuclear export (SINE) selinexor in Asian patients with advanced or metastatic malignancies
Authors: Ho Jingshan , Heong Valerie , Peng Yong Wei , Soo Ross , Ean Chee Cheng , Wong Andrea , Sundar Raghav , Liang Thian Yee , Gopinathan Anil , Yan Pang Mei , Koe Priscillia , Nathan Jeraj Santhiay , Pyar Soe Phyu , Yar Soe Mu , Tang Tiffany , Ng Matthew C.H. , Tai David W.M. , Tan Tira J.Y. , Xu Hongmei , Chang Hua , Landesman Yosef , Shah Jatin , Shacham Sharon , Chin Lee Soo , Tan Daniel S.W. , Cher Goh Boon , Tan David S.P. 
Published: April 2022

Purpose: This phase 1 study aims to evaluate the tolerability and the recommended phase 2 dose of selinexor in Asian patients with advanced or metastatic malignancies. Experimental Design: A total of 105 patients with advanced malignancies were enrolled from two sites in Singapore (National University Hospital and the National Cancer Centre, Singapore) from 24 February 2014 to 14 January 2019. We investigated four dosing schedules of selinexor in a 3 + 3 dose escalation design with an additional Phase 1b expansion cohort. Adverse events were graded with the NCI Common Terminology Criteria for Adverse Events v 4.03. Pharmacodynamic assessments included nuclear cytoplasmic localization of p27, XPO1 cargo proteins pre and post selinexor dosing and pharmacokinetic assessments were conducted at doses between 40 and 60 mg/m2. Results: In our Asian patient cohort, dosing at 40 mg/m2 given 2 out of 3 weeks, was the most tolerable for our patients. At this dose level, grade 3 adverse events included fatigue (8%), hyponatremia (23%), vomiting (5%), thrombocytopenia (5%), and anaemia (2%). Selinexor had a rapid oral absorption with median Tmax of 2 h and no PK accumulation after multiple doses of tested regimens. Complete responses were seen in two lymphoma patients. Partial responses were noted in three diffuse large B cell lymphomas, one Hodgkin’s lymphoma and thymic carcinoma patient, respectively. Conclusion: Selinexor is tolerated by Asian patients at 40 mg/m2 twice a week given 2 out of 3 weeks. A 1-week drug holiday was needed as our patients could not tolerate the current approved continuous dosing regimens because of persistent grade 3 fatigue, anorexia and hyponatremia.
COVID-19 in Long-Term Care Facilities: A Rapid Review of Infection Correlates and Impacts on Mental Health and Behaviors
Authors: Yang Haoyue , Rigsby Matilin , Zhu Xuemei , Lee Chanam , Ory Marcia 
Published: April 2022

Background: Long-term care facilities (LTCFs) with compact, group-living arrangements have become COVID-19 hot spots during the pandemic. Systematic research is needed to understand factors associated with COVID-19 infections in LTCFs and the inadvertent effects of preventive measures adopted by LTCFs. Objectives: This rapid review identifies factors associated with LTCF residents’ COVID-19 infections and the impacts of the pandemic and the corresponding preventive measures on residents’ mental health and behavioral problems. Methods: Following the preferred reporting items for systematic reviews and meta-analyses guidelines, we identified and reviewed relevant literature in Medline, PsycINFO, and AgeLine. Results: Thirty-seven articles were identified and reviewed, including 30 reporting factors associated with COVID-19 infections in LTCFs and seven reporting the impact of the pandemic and corresponding prevention measures on LTCF residents. Results revealed four domains of factors associated with COVID-19 infections: facility physical environments, resident characteristics, facility management and testing, and community factors. The pandemic and infection control measures increased residents’ depression, anxiety, loneliness, and behavioral problems (e.g., agitation, hallucinations). Residents without cognitive impairments were more vulnerable to these adverse effects. Conclusion and implications: LTCF managers/policymakers and healthcare designers can help mitigate COVID-19 infections by (1) providing additional resources to vulnerable LTCFs; (2) enhancing the training of personal protective equipment use and guideline compliance; and (3) investing in amenities, such as sinks, quarantine rooms, and outdoor spaces. Digital activities and accessible green spaces can mitigate mental health and behavior issues. Future LTCF design can benefit from flexible spaces, natural ventilation, and reducing crowding.
Training Interprofessional Staff in Whole Health Clinical Care at the Veterans Health Administration
Authors: Ametrano Rebecca M. , McGillicuddy Morgan L. , Sanyal Shefali , Topor David R. 
Published: April 2022

Introduction The Veterans Health Administration (VHA) initiated a system-wide redesign in 2011 toward a patient-centered approach called the Whole Health System (WHS) of care. Education of VHA clinical staff in WHS-informed care, Whole Health Clinical Care (WHCC), is one critical element of this redesign effort. At a minimum, WHCC education should address core competencies for clinicians and be considered satisfactory for learners. This is the first study to evaluate learner satisfaction and perceived achievement of course objectives in WHCC that incorporated active learning strategies. Method A large VA Healthcare System developed an in-person workshop focused on WHCC that used multiple active learning activities. These activities included case presentations, role playing, experiential learning, and group discussion. Results Sixty-two interprofessional staff attended the workshop in November 2019. Forty (64.50%) participants completed post-workshop surveys within 30 days. Data suggest participants were highly satisfied with the workshop and that they successfully met stated learning objectives. Conclusions We call on VHA and private-sector hospitals to train clinical staff in WHCC that incorporates use of active learning strategies.
Perceptions of Retired Nurses on Factors Preventing Younger Professional Nurses from Applying the Ethos of Ubuntu in Professional Care
Authors: Mulaudzi Fhumulani M. , Anokwuru Rafiat Ajoke , Mogale Ramadimetja , Moloko-Phiri Seepaneng Salaminah , DuPlessis Moselene AR 
Published: April 2022

Introduction Younger professional nurses are the future of the nursing profession and they receive the baton from older and retired nurses to continue the profession in good light. Ubuntu is an African philosophy that is embedded in caring ethics and it is viewed as a core value of the nursing profession and is highly valued by older nurses. Objective We explored the perceptions of retired nurses on factors that prevent younger professional nurses from applying the ethos of Ubuntu in professional care. Methods In this study, we explored the factors that prevent younger professional nurses from applying the ethos of Ubuntu in professional care. In this qualitative explorative study, data were collected during focus group discussions in a workshop held with 40 retired nurses in a province in South Africa. The transcripts were analyzed following the six steps outlined by Braun and Clarke (2006). Results Based on the perceptions of the retired nurses two main themes emerged as factors that prevent the younger professional nurses from applying the ethos of Ubuntu in their professional practice; 1) Motivation to practice Ubuntu in nursing, 2) Lack of political will to recognize nursing. Conclusion Retired nurses felt that Ubuntu could be applied in nursing care if these factors are addressed by both nurses and stakeholders.