bluuebunny/crossref_metadata_2025_split huggingface dataset:
Placenta Accreta Spectrum Disorders: A. Chohan Continuous Squeezing Suture (ACCSS) for Controlling Haemorrhage from the Lower Uterine Segment at Caesarean Section
Authors: Chohan Muhammad Arshad , Butt Prof Fauzia , Imran Dr Maria , Zahra Dr Sadaf , Chohan Dr Moiz 
Published: November 2022

Objectives: To describe the simplicity, efficacy and safety of A. Chohan Continuous Squeezing Suture (ACCSS) for controlling haemorrhage from the lower uterine segment at caesarean section for placenta Praevia and accrete spectrum disorders.
Methods: This prospective study was conducted on 47 patients with placenta Praevia and accreta spectrum disorders from February 2019 to May 2022 in two teaching hospitals of Lahore and ACCSS was applied. The outcome measures were peripartum hysterectomy procedure time, estimated blood loss, number of blood transfusions, duration of stay in the hospital, bladder trauma, uterine necrosis, pelvic abscess formation, secondary postpartum haemorrhage and maternal mortality. Descriptive statistics were calculated by using SPSS version 21.
Results: Out of 47 patients, 7 (15%) had placenta creta, 29 (61.7%) increta, 11 (23.3%) percreta (grade 3a), and 36 (76.6%) central anterior dominant placenta. Peripartum hysterectomy was prevented in 97.8% of patients. ACCSS procedure time was 5-10 minutes (87.2%), with mean blood loss 2500±485 ml, mean blood transfusion 1.85±1.02 units and mean hospital stay of 3.3±0.84 days. One patient had bladder trauma. There was no case of uterine necrosis, pelvic abscess formation, secondary postpartum haemorrhage or maternal mortality.
Conclusion: ACSS appears to be a simple, effective and safe treatment option for placenta praevia and accreta spectrum disorders, as an alternative to hysterectomy.
Registration: ClinicalTrial.gov NCT04660578, NCT05070689.
doi: https://doi.org/10.12669/pjms.39.1.6990
How to cite this: Chohan MA, Butt F, Imran M, Zahra S, Chohan MA. Placenta Accreta Spectrum Disorders: A. Chohan Continuous Squeezing Suture (ACCSS) for Controlling Haemorrhage from the Lower Uterine Segment at Caesarean Section. Pak J Med Sci. 2023;39(1):---------. doi: https://doi.org/10.12669/pjms.39.1.6990
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Determining staffing needs for improving primary health care service delivery in Kaduna State, Nigeria
Authors: Oaiya Agbonkhese I. , Tinuoye Oluwabambi , Olatawura Layi , Balarabe Hadiza , Abubakar Hamza 
Published: November 2022

Background: The equitable distribution of a skilled health workforce is critical to health service delivery. Kaduna state has taken significant steps to revamp the primary health care system to ensure access to health care for its populace. However, these investments are yet to yield the desired outcomes due to health workforce shortages and the inequitable distribution of those available. Methods: A Workload Indicator for Staffing Need (WISN) study was conducted at Kaduna state's primary health care level. The study focused on estimating staffing requirements; Nurses/Midwives and Community Health Worker practitioners, Community Health Officers, Community Health Extension Workers, and Junior Community Health Extension Workers in all government-prioritised primary health care facilities. A total of ten focal primary health care facilities in Kaduna North Local Government Area (LGA) were included in the study. Results: Findings from the study revealed a shortage of Nurses/Midwives and Community Health Workers across the study facilities. For the Nurse/Midwife staffing category, nine of the ten PHCs have a WISN ratio < 1, indicating that the number of staff in the Nurse/Midwife category is insufficient to cope with the workload. In two of the ten primary health care facilities, there is an excess in the number of CHWs available; a WISN ratio > 1 was calculated. Conclusion: The WISN study highlights staffing needs in Kaduna State's government-prioritised primary health care facilities. This evidence establishes the basis for applying an evidence-based approach to determining staffing needs across the primary health care sector in the State to guide workforce planning strategies and future investments in the health sector. The World Health Organisation (WHO) WISN tool is useful for estimating staffing needs required to cope with workload pressures, particularly in a resource-constrained environment like Kaduna State.
The effects of beliefs, knowledge, and attitude on herbal medicine use during the COVID-19 pandemic: A cross-sectional survey in Indonesia
Authors: Kristianto Heri , Pramesona Bayu Anggileo , Rosyad Yafi Sabila , Andriani Lili , Putri Tri Antika Rizki Kusuma , Rias Yohanes Andy 
Published: November 2022

Background: Herbal medicines are gaining a greater degree of popularity as complementary and alternative medicines during the COVID-19 pandemic. Nonetheless, there is a lack of data concerning the rationale for and factors influencing their use. Methods: A cross-sectional community-based online study involving 1,621 participants was conducted to explore the effects of magical health beliefs, holistic health beliefs, knowledge, and pro- complementary alternative medicine (CAM) attitudes on herbal medicine use in the Indonesian population. Results: Logistic regression findings showed that knowledge about herbal medicines was independently and positively associated with herbal medicine use to a greater extent than herbal medicine non-use (adjusted odds ratio; AOR = 1.20; 95% confidence interval; CI = 1.16 to 1.24). The participants who used herbal medicines had a greater magical health belief score than herbal medicine non-users, with AOR = 1.03 and 95% CI = 1.00 to 1.06. Moreover, holistic health beliefs and pro-CAM attitudes were also found to be independently associated with herbal medicine use. Conclusion: Magical health beliefs, holistic health belief, knowledge, and attitudes are key factor in determining the herbal medicine use. Our findings offer crucial implications for health policymakers to encourage the use of herbal medicine during the COVID-19 pandemic.
A Review of Wound Healing Mechanisms of Natural Products in Keratinocyte Cells
Authors: Fristiohady Adryan , Asasutjarit Rathapon , Julian Purnama La Ode Muh , Haruna Lidya Agriningsih , Al-Ramadan Wirhamsah 
Published: November 2022

Background: Wound-healing in the skin is one mechanism that maintains homeostasis. Ineffective skin wound healing is a significant health problem that ultimately causes morbidity and mortality. The process of wound healing using traditional medicine has a good effect with various mechanisms of action. This review aims to provide insights related to the wound-healing mechanisms of several plants in HaCat cells. Methods: The literature study method was used from primary and secondary libraries. The library search was conducted using online-based library search instruments from 1988 to 2021, such as NCBI-PubMed, Google Scholar, and Elsevier. Results: The wound-healing mechanism includes processes that restore skin integrity through four stages: hemostasis, inflammation, multiplication, and remodeling. Many plants have been studied to have activity in wound healing by various mechanisms. Conclusions: Several compounds in plants have shown the activity in wound healing in keratinocyte cells by various mechanisms.
SARS-CoV-2 and the role of close contact in transmission: a systematic review
Authors: Onakpoya Igho J. , Heneghan Carl J. , Spencer Elizabeth A. , Brassey Jon , Plüddemann Annette , Evans David H. , Conly John M. , Jefferson Tom 
Published: November 2022

Background: SARS-CoV-2 transmission has been reported to be associated with close contact with infected individuals. However, the mechanistic pathway for transmission in close contact settings is unclear. Our objective was to identify, appraise and summarise the evidence from studies assessing the role of close contact in SARS-CoV-2 transmission. Methods: This review is part of an Open Evidence Review on Transmission Dynamics of SARS-CoV-2. We conduct ongoing searches using WHO Covid-19 Database, LitCovid, medRxiv, PubMed and Google Scholar; assess study quality based on the QUADAS-2 criteria and report important findings on an ongoing basis. Results: We included 278 studies: 258 primary studies and 20 systematic reviews. The settings for primary studies were predominantly in home/quarantine facilities (39.5%) and acute care hospitals (12%). The overall reporting quality of the studies was low-to-moderate. There was significant heterogeneity in design and methodology. The frequency of attack rates (PCR testing) varied between 2.1-75%; attack rates were highest in prison and wedding venues, and in households. The frequency of secondary attack rates was 0.3-100% with rates highest in home/quarantine settings. Three studies showed no transmission if the index case was a recurrent infection. Viral culture was performed in four studies of which three found replication-competent virus; culture results were negative where index cases had recurrent infections. Eighteen studies performed genomic sequencing with phylogenetic analysis – the completeness of genomic similarity ranged from 77-100%. Findings from systematic reviews showed that children were significantly less likely to transmit SARS-CoV-2 and household contact was associated with a significantly increased risk of infection. Conclusions: The evidence from published studies demonstrates that SARS-CoV-2 can be transmitted in close contact settings. The risk of transmission is greater in household contacts. There was a wide variation in methodology. Standardized guidelines for reporting transmission in close contact settings should be developed.
Improving physical and psychological outcomes of cardiac patients using the Naluri app: A study protocol for a randomized controlled trial
Authors: Fadil Azim Darlina H. , Mohd Ghazi Azmee , Ong Siew Hoon , Abdul Majid Hariyati S. , Morgan Karen , Hickey Anne 
Published: November 2022

Background: Coronary artery disease (CAD) continues to be a significant burden to public health. Poor treatment and management can lead to more severe cardiac events that could result in death or disability. Early interventions like cardiac rehabilitation programs can provide patients the required knowledge, skills and support to recover from and prevent more cardiac events. Electronic health (eHealth) interventions have potential to complement hospital-based rehabilitation programs. This study aims to investigate the effectiveness of the Naluri app in improving health behaviours, clinical and psychological outcomes in a sample of cardiac patients in Malaysia. Methods: This study is a two-arm, parallel, superiority randomized control trial to be conducted at the Malaysian National Heart Institute. A total of 200 patients will be randomly assigned to either a 16-week theory-based Naluri app in addition to usual care (treatment) or to usual care only (control). Outcomes will be measured at baseline and at 16 weeks. Health behaviour outcomes include physical activity and diet. Clinical outcomes include BMI, hemoglobin A1c (HbA1c), and lipid levels. Psychological outcomes include anxiety, depression, and health related quality of life (HRQOL). The Naluri app theoretical framework is based on the Health Action Process Approach (HAPA) theory. Risk perception, self-efficacy, planning, intentions, outcome expectancies, illness perceptions and psychological outcomes will be measured using self-reported measures. Discussion: This trial will determine the effectiveness of the Naluri app intervention in improving various outcomes of cardiac patients after four months. It will provide data on the applicability of the HAPA theory in Mobile health (mHealth) intervention and the acceptance and efficacy of mHealth as a cardiac rehabilitation program for patients in Malaysia. The results may inform the potential implementation of the app for use with patients with other chronic illnesses like diabetes, stroke, and depression. Registration: Australia New Zealand Clinical Trials Registry (14/01/2019, ACTRN12619000104156).
Identification of putative reader proteins of 5-methylcytosine and its derivatives in Caenorhabditis elegans RNA
Authors: Navarro IC , Suen Kin Man , Bensaddek Dalila , Tanpure Arun , Lamond Angus , Balasubramanian Shankar , Miska Eric A 
Published: November 2022

Background: Methylation of carbon-5 of cytosines (m5C) is a conserved post-transcriptional nucleotide modification of RNA with widespread distribution across organisms. It can be further modified to yield 5-hydroxymethylcytidine (hm5C), 5-formylcytidine (f5C), 2´-O-methyl-5-hydroxymethylcytidine (hm5Cm) and 2´-O-methyl-5-formylcytidine (f5Cm). How m5C, and specially its derivates, contribute to biology mechanistically is poorly understood. We recently showed that m5C is required for Caenorhabditis elegans development and fertility under heat stress. m5C has been shown to participate in mRNA transport and maintain mRNA stability through its recognition by the reader proteins ALYREF and YBX1, respectively. Hence, identifying readers for RNA modifications can enhance our understanding in the biological roles of these modifications. Methods: To contribute to the understanding of how m5C and its oxidative derivatives mediate their functions, we developed RNA baits bearing modified cytosines in diverse structural contexts to pulldown potential readers in C. elegans. Potential readers were identified using mass spectrometry. The interaction of two of the putative readers with m5C was validated using immunoblotting. Results: Our mass spectrometry analyses revealed unique binding proteins for each of the modifications. In silico analysis for phenotype enrichments suggested that hm5Cm unique readers are enriched in proteins involved in RNA processing, while readers for m5C, hm5C and f5C are involved in germline processes. We validated our dataset by demonstrating that the nematode ALYREF homologues ALY-1 and ALY-2 preferentially bind m5C in vitro. Finally, sequence alignment analysis showed that several of the putative m5C readers contain the conserved RNA recognition motif (RRM), including ALY-1 and ALY-2. Conclusions: The dataset presented here serves as an important scientific resource that will support the discovery of new functions of m5C and its derivatives. Furthermore, we demonstrate that ALY-1 and ALY-2 bind to m5C in C. elegans.
Predictors of fear of falling among community-dwelling older adults: Cross-sectional study from Palestine
Authors: Badrasawi Manal , Hamdan May , Vanoh Divya , Zidan Souzan , ALsaied Tasneem , Muhtaseb Tala B. 
Published: November 2022

Introduction
Fear of falling has serious implications for health and is an important threat to autonomy. The purpose of this cross-sectional study was to investigate risk factors for fear of falling among Palestinian older adults in Hebron district.

Methods
A cross-sectional study was conducted among Palestinians > 60 years living in Hebron, West Bank. The Falls Efficacy Scale-International was used to predict falls among Palestinian older adults. Moreover, socio-demographic data, medical history, lifestyle habits, body composition, nutritional status, cognitive status (using the Montreal cognitive assessment tool), and functional status (using activities of daily living and instrumental activities of daily living scale), the presence of depressive symptoms (using geriatric depression scale), and physical fitness performance (using senior fitness test) were collected through an interview-based questionnaire. Data were analyzed using univariate and multivariate approach.

Results
A total of 200 participants were included in the study; 137 (68.5%) females and 63 (31.5%) males. Mean age was 70.5 ± 5.7 years, ranged from 65 to 98 years old. Fear of falling was significantly higher among older adults with advanced aged, living in villages or camps, low educational level, and being married (p < 0.05). Functional status (ADL and IADL), physical fitness status (timed up and go), and depression symptoms were significantly related to fear of falling (p < 0.05).

Conclusion
High concern of falling is significantly associated with advanced age, low education level, being married, and living in villages or camps. ADLs were among the factors that had a significant relationship with increased fear of falling. Predictors of fear of falling among Palestinian older adults were IADL scores, body fat percentage, rapid gait speed, timed up and go test. Future studies could investigate further correlates of fear of falling among older adults.
Association between subjective health status and frequency of visits to acupuncture clinic: A cross-sectional study
Authors: Kayo Takumi , Suzuki Masao , Kato Ryuji , Ishizaki Naoto , Mitsuma Tadamichi , Fukuda Fumihiko 
Published: November 2022

Objective
There are few studies on the relationship between the frequency of acupuncture use and subjective health status. Therefore, we investigated this relationship using data of a previously performed cross-sectional survey of patients visiting Japanese acupuncture clinics.

Methods
This study used data from a cross-sectional survey conducted in 2011 on patients visiting 180 acupuncture clinics nationwide that were run by members of the alumni association of Meiji University of Integrative Medicine Faculty of Acupuncture and Moxibustion, and did not provide treatment other than acupuncture. We calculated the frequency of visits to acupuncture clinics (< 24 times, 24–47 times, 48–95 times, or ≥ 96 times per year) and the Short Form-36 (SF-36) summary scores (physical, mental, role/social) based on the response of the questionnaire conducted at the time of the survey. Multiple linear regression analysis with multiple imputation was performed with three SF-36 summary scores as the dependent variables, and the frequency of visits to acupuncture clinics as the independent variable.

Results
The questionnaire was distributed to 2,379 outpatients of acupuncture clinics, 1,409 of whom met the criteria and were included in the analysis. More frequent visits to acupuncture clinics were associated with lower scores on all three SF-36 summary scores. Compared to those who visited < 24 times a year, those who visited ≥ 96 times a year had unstandardized regression coefficients (95% confidence interval) of -5.6 (-7.8 to -3.3) for the physical, -2.0 (-3.9 to -0.1) for the mental, and -2.9 (-5.4 to -0.4) for the role/social SF-36.

Conclusions
Frequent visits to acupuncture clinics were associated with poor subjective health status, especially physical health.
A mámoron és az igézeten túl
Authors: Z. Karvalics László 
Published: November 2022

As an introduction to a special, thematic issue, the author reviews four possible analytic approach to information history centered view of lists. The microhistory explanation (1), a tipology-driven, time-sensitive contextualization (through melting the given type of list with similar ones, extending the scope to other information managing objects, actors and institutions of a given age (2), the macrohistory framing, when we try to insert the list into different sets of trendlines and trajectories (3), and a group of content-oriented, functional, structural points of views, reviving the epistemological nature of list-making, regarding to different societies, cultures and situations (4).After speculating on the validity and possible significance of a substantive and dedicated ‘science of lists’, the author summarizes the aspects, which can be devoted to specially information history-related dissections.
Aktualisasi Nilai-Nilai Pancasila dalam Kehidupan Berbangsa dan Bernegara di Era Generasi Milenial
Authors: Mulyaningrum Chitra Wahyu , Pratama Iqbal Bagas , Oktavia Nadia Ria , Fitriono Riska Andi 
Published: November 2022

The dynamics in actualizing the values of Pancasila in the life of the nation and state in the era of the millennial generation is a form of necessity, so that Pancasila is always aligned in its function to provide guidance in the life of the nation and state as a policy-making and solving problems. Pancasila values have been inculcated since childhood, but if they are not studied and understood, they will easily fade. The millennial era is currently in the midst of the swift currents of western globalization. Pancasila values should be engraved in the spirit and brain of the ongoing millennium. The implied values contained in Pancasila are key in regulating individual behavior and mentality.
Operation Moonshot: rapid translation of a SARS-CoV-2 targeted peptide immunoaffinity liquid chromatography-tandem mass spectrometry test from research into routine clinical use
Authors: Hällqvist Jenny , Lane Dan , Shapanis Andrew , Davis Kayleigh , Heywood Wendy E. , Doykov Ivan , Śpiewak Justyna , Ghansah Nana , Keevil Brian , Gupta Pankaj , Jukes-Jones Rebekah , Singh Raj , Foley Dominic , Vissers Johannes P.C. , Pattison Rebecca , Ferries Samantha , Wardle Robert , Bartlett Amy , Calton Lisa J. , Anderson Leigh , Razavi Morteza , Pearson Terry , Pope Matt , Yip Richard , Ng Leong L. , Nicholas Benjamin I. , Bailey Alistair , Noel Dan , Dalton R. Neil , Heales Simon , Hopley Christopher , Pitt Andrew R. , Barran Perdita , Jones Donald J. L. , Mills Kevin , Skipp Paul , Carling Rachel S. 
Published: November 2022

Abstract

Objectives
During 2020, the UK’s Department of Health and Social Care (DHSC) established the Moonshot programme to fund various diagnostic approaches for the detection of SARS-CoV-2, the pathogen behind the COVID-19 pandemic. Mass spectrometry was one of the technologies proposed to increase testing capacity.

Methods
Moonshot funded a multi-phase development programme, bringing together experts from academia, industry and the NHS to develop a state-of-the-art targeted protein assay utilising enrichment and liquid chromatography tandem mass spectrometry (LC-MS/MS) to capture and detect low levels of tryptic peptides derived from SARS-CoV-2 virus. The assay relies on detection of target peptides, ADETQALPQRK (ADE) and AYNVTQAFGR (AYN), derived from the nucleocapsid protein of SARS-CoV-2, measurement of which allowed the specific, sensitive, and robust detection of the virus from nasopharyngeal (NP) swabs. The diagnostic sensitivity and specificity of LC-MS/MS was compared with reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) via a prospective study.

Results
Analysis of NP swabs (n=361) with a median RT-qPCR quantification cycle (Cq) of 27 (range 16.7–39.1) demonstrated diagnostic sensitivity of 92.4% (87.4–95.5), specificity of 97.4% (94.0–98.9) and near total concordance with RT-qPCR (Cohen’s Kappa 0.90). Excluding Cq>32 samples, sensitivity was 97.9% (94.1–99.3), specificity 97.4% (94.0–98.9) and Cohen’s Kappa 0.95.

Conclusions
This unique collaboration between academia, industry and the NHS enabled development, translation, and validation of a SARS-CoV-2 method in NP swabs to be achieved in 5 months. This pilot provides a model and pipeline for future accelerated development and implementation of LC-MS/MS protein/peptide assays into the routine clinical laboratory.
Crystal structure of bis(μ2-5-chloro-2-oxido-N-(1-oxido-2-oxo-2-phenylethylidene)-benzohydrazonato-κ5
N,O,O′:N′,O′′)-oktakis(pyridine-κ1
N)trinickel(II) – methanol – pyridine (1/1/1) C76H65N13Cl2Ni3O9
Authors: Zhongyuan Zhou , Liguo Yang , Kun Zou , Jiaqi Fu , Xinyu Ji 
Published: November 2022

Abstract
C76H65N13Cl2Ni3O9, monoclinic, P21/n, a = 15.937(4) Å, b = 16.805(4) Å, c = 27.463(7) Å, β = 94.613(3)°, V = 7332(3) Å3, Z = 4, Rgt
(F) = 0.0490, wRref
(F
2) = 0.1596, T = 298 K.