bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multidisciplinary Team Meeting Proposal and Final Therapeutic Choice in Early Breast Cancer: Is There an Agreement?
Authors: Bortot Lucia , Targato Giada , Noto Claudia , Giavarra Marco , Palmero Lorenza , Zara Diego , Bertoli Elisa , Dri Arianna , Andreetta Claudia , Pascoletti Gaetano , Poletto Elena , Russo Stefania , Seriau Luca , Mansutti Mauro , Cedolini Carla , Basile Debora , Fasola Gianpiero , Bonotto Marta , Minisini Alessandro Marco 
Published: June 2022

BackgroundA multidisciplinary team meeting (MDM) approach in breast cancer (BC) management is a standard of care. One of the roles of MDMs is to identify the best diagnostic and therapeutic strategies for patients (pts) with new diagnosis of early BC. The purpose of this study was to define whether there was an agreement between the planned program (i.e., MDMs-based decision) and that actually applied. In addition, the study explored factors associated with discordance.MethodsWe conducted a retrospective study of a consecutive series of 291 patients with new diagnosis of early BC, discussed at MDMs at the University Hospital of Udine (Italy), from January 2017 to June 2018. The association between clinico-biological factors and discordance between what was decided during the MDMs and what was consequently applied by the oncologist was explored through uni- and multivariate logistic regression analyses.ResultsThe median age was 62 years (range 27–88 years). Among invasive early BC patients, the most frequent phenotype was luminal A (38%), followed by luminal B (33%), HER2-positive (12%), and triple-negative (5%). In situ carcinoma (DCIS) represented 12% of cases. The median time from MDM discussion to first oncologic examination was 2 weeks. The rate of discordance between MDM-based decision and final choice, during a face-to-face consultation with the oncologist, was 15.8% (46/291). The most frequent reason for changing the MDM-based program was clinical decision (87%). Follow-up was preferred to the chemotherapy (CT) proposed within the MDMs in 15% of cases, and to the endocrine therapy (ET) in 39% of cases (among these, 44.5% had a diagnosis of DCIS). Therapeutic change from sequential CT-ET to ET alone was chosen in 16/46 pts (35%): among these patients, seven had a luminal B disease and six had an HER2-positive disease. On univariate analysis, factors associated with discordance were values of Ki-67 14%–30% (OR 3.91; 95% CI 1.19–12.9), age &gt;70 years (OR 2.44, 95% CI 1.28–4.63), housewife/retired status (OR 2.35, 95% CI 1.14–4.85), polypharmacy (OR 1.95; 95% CI 1.02–3.72), postmenopausal status (OR 4.15; 95% CI 1.58–10.9), and high Charlson Comorbidity Index (OR 1.31; 95% CI 1.09–1.57). The association with marital status, educational level, alcohol and smoke habits, presence of a caregiver, parity, grading, histotype and phenotype, and stage was not statistically significant. On multivariate analysis, only Ki-67 value maintained its statistical significance.ConclusionThe results of our study could be useful for enhancing the role of MDMs in the clinical decision-making process in early BC.
Anopheles stephensi Feeding, Flight Behavior, and Infection With Malaria Parasites are Altered by Ingestion of Serotonin
Authors: Briggs Anna M. , Hambly Malayna G. , Simão-Gurge Raquel M. , Garrison Sarah M. , Khaku Zainab , Van Susteren Grace , Lewis Edwin E. , Riffell Jeffrey A. , Luckhart Shirley 
Published: June 2022

Approximately 3.4 billion people are at risk of malaria, a disease caused by infection with Plasmodium spp. parasites, which are transmitted by Anopheles mosquitoes. Individuals with severe falciparum malaria often exhibit changes in circulating blood levels of biogenic amines, including reduced serotonin or 5-hydroxytryptamine (5-HT), and these changes are associated with disease pathology. In insects, 5-HT functions as an important neurotransmitter for many behaviors and biological functions. In Anopheles stephensi, we show that 5-HT is localized to innervation in the head, thorax, and midgut, suggesting a gut-to-brain signaling axis that could support the effects of ingested 5-HT on mosquito biology and behavioral responses. Given the changes in blood levels of 5-HT associated with severe malaria and the key roles that 5-HT plays in insect neurophysiology, we investigated the impact of ingesting blood with healthy levels of 5-HT (1.5 µM) or malaria-associated levels of 5-HT (0.15 µM) on various aspects of A. stephensi biology. In these studies, we provisioned 5-HT and monitored fecundity, lifespan, flight behavior, and blood feeding of A. stephensi. We also assessed the impact of 5-HT ingestion on infection of A. stephensi with the mouse malaria parasite Plasmodium yoelii yoelii 17XNL and the human malaria parasite Plasmodium falciparum. Our data show that ingestion of 5-HT associated with severe malaria increased mosquito flight velocity and investigation of visual objects in response to host odor (CO2). 5-HT ingestion in blood at levels associated with severe malaria also increased the tendency to take a second blood meal 4 days later in uninfected A. stephensi. In mosquitoes infected with P. y. yoelii 17XNL, feeding tendency was decreased when midgut oocysts were present but increased when sporozoites were present. In addition to these effects, treatment of A. stephensi with 5-HT associated with severe malaria increased infection success with P. y. yoelii 17XNL compared to control, while treatment with healthy levels of 5-HT decreased infection success with P. falciparum. These changes in mosquito behavior and infection success could be used as a basis to manipulate 5-HT signaling in vector mosquitoes for improved control of malaria parasite transmission.
Clinical Predictive Models for Delayed Cerebral Infarction After Ruptured Intracranial Aneurysm Clipping for Patients: A Retrospective Study
Authors: Su Jun , Huang Hao , Xin Yuan-jun , Liang Yi-dan , Wu Xin-tong , Yang Xiao-lin , Liu Xiao-zhu , He Zhaohui 
Published: June 2022

ObjectiveA nomogram was developed in this work to predict the probability of delayed cerebral infarction (DCI) after ruptured intracranial aneurysms (RIA) clipping.MethodsClinical data of patients with intracranial aneurysm were obtained from the neurosurgery department of the First Affiliated Hospital of Chongqing Medical University from January 2016 to December 2020. A total of 419 patients receiving surgery of ruptured intracranial aneurysm clipping were included and a total of 37 patients with DCI were set as the observation group. The control group consisted of 382 patients without DCI. Risk factors of DCI were screened by univariate and multivariate logistic regression analysis and included in the nomogram.ResultsUnivariate analysis showed that female (P = 0.009), small aneurysm (P = 0.031), intraoperative aneurysm rupture (P = 0.007) and cerebral vasospasm (P &lt; 0.001) were risk factors for postoperative DCI while smoking history (P = 0.044) were protective factors for postoperative DCI. Multivariate Logistic regression analysis showed that small aneurysm (P = 0.002, OR = 3.332, 95%–7.104), intraoperative aneurysm rupture (P = 0.004, OR = 0.122, 95%-CI, 0.029–0.504)and cerebral vasospasm (P &lt; 0.001, OR = 0.153, 95%-CI, 0.070–0.333) were independent risk factors of postoperative DCI. The calibration curve of the probability of occurrence showed that the nomogram was in good correspondence with the observed results with a C-index of 0.766 (95% CI, 0.684–0.848). Meanwhile, the Decision curve analysis (DCA) showed that the established predictive model had a good clinical net benefit.ConclusionThe well-established nomogram is expected to be an effective tool to predict the occurrence of DCI after intracranial ruptured aneurysm and can be used to assist clinicians to develop more effective treatment strategies and improve the prognosis of patients.
SLAM: NA ENGRENAGEM, A CONTRA-MOLA QUE RESISTE!
Authors: Carneiro Gizele Cristiana , Kasper Kátia Maria 
Published: June 2022

Escreve-se em travessia ao caos. A linha: o Slam. Acontecimento ocupando espaços à margem, território de potência. É das vibrações sentidas nesse lugar de batalha e daquilo que afeta num clamor por resistência, que se efetiva uma escrita poética de recusa.
Aplicação algébrica para se calcular o valor da raiz quadrada de um número natural não-quadrado perfeito pelo método iterativo babilônico / An algebraic application for calculating the square root of a non-square perfect natural number by the iterative babylonian method
Authors: Saraiva Odirley Willians Miranda , Dias Gustavo Nogueira , Vogado Gilberto Emanoel Reis , Barbosa Eldilene da Silva , Loureiro Rondineli Carneiro , Barreto Wagner Davy Lucas , Beirão Antonio Thiago Madeira , Silva Katiane Pereira da , Junior Washington Luiz Pedrosa da Silva , Cardoso Waljucy Furtado 
Published: June 2022

A matemática passou por muitas transformações ao longo da história da humanidade. Embora, as atuais mudanças a tornaram mais sofisticadas, do que no passado, e hoje se façam muitos cálculos, com o auxílio dos computadores atuais, na utilização de algoritmos preestabelecidos em softwares, não se deve esquecer como tais algoritmos foram criados. Numa perspectiva para os leigos, que desconhecem a matemática desenvolvidas por civilizações antigas, muitos dos algoritmos que ainda operam hoje em avançados sistemas de computadores, foram criados por civilizações que dominaram os primeiros quatro milênios antes da era comum, como: os babilônicos e posteriormente gregos. Que, até hoje, estes povos despertam a admiração e beleza, para a aqueles que, apreciam a arte que as generalizações matemáticas podem alcançar. Logo, o objetivo deste trabalho é apresentar, entre tantos métodos existentes, o método iterativo babilônico para se calcular a raiz quadrada de um número natural não quadrado perfeito, como forma alternativa, em relação ao métodos das tentativas e a utilização da calculadora e outros dispositivos eletrônicos que de longe são os mais utilizados para se calcular raiz quadrada.
Estresse no trabalho relacionado ao exercício da docência no ensino superior / Work stress related ated to the exercise of teaching in higher education
Authors: Alves Ana Paula de Oliveira Nascimento , Siqueira Leila das Graças , Versiani Claudia Mendes Campos , Nunes Raynara Laurinda Nascimento , Silva Carla Silvana de oliveira e , Souza Lucas Faustino de , Junior Rene Ferreira da Silva , Oliveira Suzane Fonseca , Silva Deiviane Pereira da , Teles Mariza Alves Barbosa , Teixeira Nadine Antunes , Dias Ana Catarina Perez 
Published: June 2022

Objetivo: Avaliar o nível de estresse de docentes atuantes no ensino superior público. Realizou-se um estudo epidemiológico, transversal e analítico, com docentes atuantes em cursos de graduação da área de saúde da Universidade Federal dos Vales do Jequitinhonha e Mucuri no ano de 2019. Métodos: Como instrumento, utilizou-se a Escala de Estresse no Trabalho (EET) associada a um questionário para investigar as características sociodemográficas, de formação, trabalho e saúde. Foi realizada a análise descritiva e bivariada por meio do teste qui-quadrado. Resultados: Os resultados encontrados pela classificação dos escores totais na Escala de Estresse no Trabalho evidenciaram preponderância de baixo nível de estresse em todas as variáveis analisadas. Os docentes do estudo possuíam baixos níveis de estresse. Conclusão: Conclui-se que os docentes deste estudo apresentaram baixo nível de estresse, entretanto, é indispensável considerar os fatores estressantes desses profissionais a fim de produzir um ambiente favorável à qualidade de vida e do trabalho docente.
«Необъяснимо, но хайп!» Функционирование лексемы хайп и её производных в современных российских СМИ и интернет-дискурсе
Authors: Lyakhova Mariya 
Published: June 2022

Le présent travail se propose d’examiner le fonctionnement du lexème hype, récemment emprunté par le russe à l’anglais, qui semble gagner le droit de cité dans le discours de l’internet et des médias voire se généraliser par le biais du parler « jeune ». Après avoir précisé l’étymologie et répertorié les différentes valeurs sémantiques, l’auteur démontre une assimilation progressive de ce lexème par la langue russe aux niveaux morphologique et syntaxique. L’auteur retrace ensuite l’évolution de son fonctionnement discursif et évoque les explications possibles de sa « longévité » comparativement à d’autres néologismes avant de conclure sur son évaluation axiologique et les perspectives de son intégration dans la langue russe à long terme.
Longitudinal mode control in long cavity VCSELs with a curved mirror
Authors: Kearns Jared A. , Hamaguchi Tatsushi , Hayashi Kentaro , Ohara Maho , Makino Tomohiro , Ito Maiko , Kobayashi Noriko , Jyoukawa Tatsurou , Nakayama Eiji , Nagane Shoetsu , Sato Koichi , Nakamura Yuki , Hoshina Yukio , Koda Rintaro , Futagawa Noriyuki 
Published: June 2022

Abstract
A single cavity filtering mirror with a highly varying reflectivity spectrum was used to demonstrate a single longitudinal mode operation for a VCSEL with a ∼25 μm cavity length. The 443.5 nm lasing peak had an SMSR of 42 dB at 9 mA, 70 kA cm−2. Increasing the number of DBR pairs between the VCSEL and filtering mirror cavity reduced the simulated optical standing wave in the mirror cavity by 57% and experimentally gave a 42% increase in the slope efficiency to achieve 2.56 mW at 7 mA from a device with a 4 μm aperture with a single longitudinal mode.
Unification of gravitation and electromagnetic force (Third Portion)
Authors: Zheng shengming Physicist 
Published: June 2022

<p> According to new discovery of law of moving photon does create force, we can know the reason why the photon become to electron-positron pair and can get that the elementary particle in Nature is photon, from this we can know the basic composition of matter is photon, in other words: the matter of producing gravitation and electromagnetic force is based on the same matter: photon. Meanwhile here show the Millikan's elementary charge is not universal law, reveal the essence of matter wave is due to force. </p>
FSSA: Efficient 3-Round Secure Aggregation for Privacy-Preserving Federated Learning
Authors: Luo Fucai 
Published: June 2022

<p>Federated learning (FL) allows a large number of clients to collaboratively train machine learning (ML) models by sending only their local gradients to a central server for aggregation in each training iteration, without sending their raw training data. This paper proposes a 3-round secure aggregation protocol, that is effificient in terms of computation and communication, and resilient to client dropouts.</p>
PERANCANGAN SISTEM MONITORING KECEPATAN KENDARAAN DI BANDARA BERBASIS GPS DENGAN FITUR GEOFENCE DAN WIRELESS
Authors: Asardin La Ode Muhammad , Kasrani Mayda Waruni , Saiful Rahman Aswadul Fitri 
Published: June 2022

Dalam dunia robotika khususnya bagi pengguna NodeMcu ESP 8266 maka pastinya menggunakan software Arduino IDE dalam programannya. Maka dari itu teknologi yang dikembangkan dalam penulisan ini membantu dalam menghitung kecepatan kendaraan. Dihubungkan melalui android yang akan memonitoring suatu kendaraan tersebut, system monitoring ini bekerja membaca kecepatan kendaraan yang dimana ketika kendaraan melakukan pelanggaran maka kecepatan akan di monitoring melalui Smartphone Android dan buzzer dalam system ini sebagai alarm pengingat di kendaraan dimana ketika kendaraan melaju di kecepatan 25 km/jam alarm akan memberitahukan bahwa kendaraan telah melampaui batas yang ditentukan. alarm ini bekerja ketika sebelum 25 km/jam kecepatan alarm memberitahukan melalui bunyi yang sangat pelan tetapi ketika melebihi dari 25 km/jam alarm berbunyi nyaring. Dan juga ketika melewati pembatas lokasi yang dimana ketika kendaraan berada di luar batas yang di tentukan maka kecepatan kendaraan tidak bisa di monitoring malalui system tetapi jika kendaraan masuk lagi di area yg di tentukan system akan dapat memonitoring kecepatan kendaraan lagi.
PERANCANGAN SISTEM PENGENDALIAN KECERAHAN LAMPU UTAMA PADA MOBIL BERBASIS ARDUINO UNO
Authors: Kasrani Mayda Waruni , B A. Asni , Putra Agi Setia 
Published: June 2022

Intisari— Pada penelitian ini di lakukan perancangan sebuah sistem pengendali kecerahan lampu utama pada mobil berbasis Arduino Uno. Tujuan dari sistem ini adalah membuat dan merancang sistem otomatisasi yang dapat mengendalikan kecerahan lampu utama pada mobil berdasarkan parameter keadaan di sekitar yang di lalui kendaraan tersebut. Dengan sistem ini diharapkan dapat lebih mengoptimalkan penggunaan daya pada baterai mobil. Dengan alasan tersebut maka di gunakanlah metode Fuzzy Logic untuk pengambilan keputusan. Penggunaan metode ini karena solusi dari kondisi-kondisi yang terjadi dalam berkendara dapat di parameterkan menggunakan metode Fuzzy. Masukan dari metode ini adalah tingkat kecerahan cahaya yang di baca oleh sensor BH1750 dan jarak kendaraan lain yang berada di depannya di baca oleh sensor HCSR04. Parameter jarak dan kecerahan cahaya tersebutlah yang di gunakan peneulis sebagai penentu fuzzy rule dari sistem ini. Dimana hasil pembacaan kedua sensor tersebut akan mempengaruhi nilai PWM Out dari Arduino tersebut. Dan perubahan nilai PWM tersebut akan berpengaruh terhadap tingkat kecerahan lampu utama mobil tersebut. Hasil dari dari pengontrolan kecerahan cahaya ini cukup efektif dalam menjaga efisiensi tegangan. Pada kondisi Low-Beam tegangan rata-rata 1,6 Volt, Pada kondisi Med-Beam 4,9 Volt, dan pada kondisi High-Beam 8,6 Volt.
Efek Moderasi Kualitas Tata Kelola Perusahaan dari Pengaruh Modal Intelektual dan Pengungkapan Tanggung Jawab Sosial Perusahaan terhadap Kinerja Pasar
Authors: Hariadi Sugeng , Waikabu Indah Sari S 
Published: June 2022

– Tujuan dari penelitian ini adalah untuk menganalisis efek moderasi kualitas tata kelola perusahaan dari pengaruh modal intelektual dan pengungkapan tanggung jawab sosial perusahaan terhadap kinerja pasar. Populasi yang digunakan adalah industri Jasa tahun 2016 - 2019 yang ada pada penilaian IICG (The Indonesian Institute for Corporate Governance). Sampel terkumpul sebanyak 28 data dengan menggunakan metode purposive sampling, dan variabel yang digunakan yaitu pengungkapan tanggung jawab sosial perusahaan dan modal intelektual sebagai variabel independen, kinerja pasar sebagai variabel dependen dan kualitas tata kelola perusahaan sebagai variabel moderasi. Alat analisis yang digunakan analisis Regresi Moderated Regression Analysis dan regresi linear berganda. Hasil penelitian menunjukkan bahwa 1) Pengungkapan tanggung jawab sosial perusahaan berpengaruh secara positif signifikan terhadap kinerja pasar. 2) Modal intelektual berpengaruh secara positif signifikan terhadap kinerja pasar. 3) Kualitas tata kelola perusahaan sebagai moderating tidak terbukti memperkuat hubungan antara pengungkapan tanggung jawab sosial perusahaan terhadap kinerja pasar. 4) Kualitas tata kelola perusahaan sebagai moderating mampu memoderasi secara signifikan hubungan antara modal intelektual terhadap kinerja pasar.

Kata Kunci: kinerja pasar, modal intelektual, pengungkapan tanggung jawab sosial perusahaan, kualitas tata kelola perusahaan
Product Design of Card Game with the Theme of Mental Health for Teenagers
Authors: Gunawan Livia Angelica 
Published: June 2022

This research contains the product development of the card game, Wellbeing, which is a game published under Petualangan Menuju Sesuatu that attempts to simulate different events and coping mechanisms as a means to educate players about mental health management. The methods used in this research are qualitative and quantitative research through interviews with expert and extreme users, as well as surveys to the target consumer and literature studies. The purpose of this research is to discover whether or not the card game, Wellbeing, is already able to answer the needs of its target market. The results afterwards show that the game is already able to garner positive response from the public as well as provide them with content that can give appropriate educational value and thereby solve the problem which is the lack of coherence between the initial iteration of the product and its target market at the time.

Keywords: board game, educational game, mental health literacy, gameplay mechanic, target market fit
Derechos reales disposiciones generales en el CCCN
Authors: Díaz Reyna José Manuel 
Published: June 2022

I) Introducción.
II) Parte general de todos los derechos reales.
III) Principios comunes. A) Concepto de derecho real, y numerus clausus. B) Efectos de la violación del numerus clausus. C) Convalidación, aplicación a la hipoteca. D) El jus preferendi y jus persecuendi. E) Enumeración. Consideraciones. F) Clasificaciones. Presunción. G) Ejercicio de los derechos reales. Cuasiposesión.
IV) Adquisición, transmisión, extinción y oponibilidad. A) Necesidad del modo tradición. B) OpombiUdad. Publicidad posesoria y registral. C] Falta de publicidad. No invocable. D) Adquisición legal de muebles por subadquirente. E) Muebles registrables y buena fe. F) Prohibición a los jueces. G) Modo prescripción adquisitiva breve. Novedad. H) Prescripción breve cosas muebles robadas o perdidas. I) La buena fe para prescripción breve. J) Posesión ostensible. K) Posesión continua. L) Unión de posesiones. M) Juicio de usucapión. N) Transmisibilidad y extinción.
V) Disposiciones generales dentro de los derechos específicos.
VI) Conclusiones.
Prueba sobre el carácter propio o ganancial de los bienes.
Authors: Pappano Ana Laura 
Published: June 2022

I. Introducción.
II. Bienes propios y gananciales en el Código Civil y Comercial.
III. Oponiblilidad entre partes y frente a terceros.
IV. Artículo 466 CCYCN. Principio general de Presunción de Ganancialidad.
V. Medios de Prueba.
VI. Omisión Declaración Bien Propio en Escrituras.
VII. Vía judicial.
VIII. Conclusiones.
IX. Bibliografía.
Graphitic carbon nitride-based upconversion photocatalyst for hydrogen production and water purification
Authors: Sudhaik Anita , Raizada Pankaj , Khan Aftab Aslam Parwaz , Singh Arachana , Singh Pardeep 
Published: June 2022

Upconversion luminescence (UCL) is mainly a nonlinear optical method that some engineered nanomaterials can attain and helps in the transformation of low energy phonons (near-infrared photons) into higher energy phonons (ultraviolet (UV) and visible light photons). Upconversion (UC) nanomaterials are a suitable candidate for preparing near-infrared (NIR) light-responsive photocatalytic systems by mixing with other photocatalysts. Many reports have been published on lanthanide-based UC materials (Ln3+ ions as dopants) and carbon quantum dots (CQDs) carrying UC property with their use in photocatalytic removal of pollutants and energy production. Besides these UC nanomaterials, graphitic carbon nitride (g-C3N4) as a potential photocatalyst (metal-free and ecofriendly) has gained attention owing to its unique and amazing possessions. But some limitations and inadequate utilization of visible light restrict its photocatalytic applicability. Therefore, to enhance or widen its light-harvesting property towards the NIR region, the integration of upconversion nanocrystals (UC NCs) into g-C3N4 is considered an effective approach. Thus, the present review is focused on the amalgamation of g-C3N4 with UC nanomaterials for full solar spectrum absorption in H2 production and pollutant degradation via NIR light absorption.