bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reorganization of 3D genome architecture across wild boar and Bama pig adipose tissues
Authors: Zhang Jiaman , Liu Pengliang , He Mengnan , Wang Yujie , Kui Hua , Jin Long , Li Diyan , Li Mingzhou 
Published: March 2022

Abstract
Background
A growing body of evidence has revealed that the mammalian genome is organized into hierarchical layers that are closely correlated with and may even be causally linked with variations in gene expression. Recent studies have characterized chromatin organization in various porcine tissues and cell types and compared them among species and during the early development of pigs. However, how chromatin organization differs among pig breeds is poorly understood.

Results
In this study, we investigated the 3D genome organization and performed transcriptome characterization of two adipose depots (upper layer of backfat [ULB] and greater omentum [GOM]) in wild boars and Bama pigs; the latter is a typical indigenous pig in China. We found that over 95% of the A/B compartments and topologically associating domains (TADs) are stable between wild boars and Bama pigs. In contrast, more than 70% of promoter-enhancer interactions (PEIs) are dynamic and widespread, involving over a thousand genes. Alterations in chromatin structure are associated with changes in the expression of genes that are involved in widespread biological functions such as basic cellular functions, endocrine function, energy metabolism and the immune response. Approximately 95% and 97% of the genes associated with reorganized A/B compartments and PEIs in the two pig breeds differed between GOM and ULB, respectively.

Conclusions
We reported 3D genome organization in adipose depots from different pig breeds. In a comparison of Bama pigs and wild boar, large-scale compartments and TADs were mostly conserved, while fine-scale PEIs were extensively reorganized. The chromatin architecture in these two pig breeds was reorganized in an adipose depot-specific manner. These results contribute to determining the regulatory mechanism of phenotypic differences between Bama pigs and wild boar.
The compassionate love for humanity scale (CLS-H-SF): psychometric properties of the Persian version
Authors: Hajiheydari Zahra , Abdollahi Abbas , Jasim Saade Abdalkareem , Alghazali Tawfeeq Abdulameer Hashim , Chupradit Supat , McGlinchey Caomhán , Allen Kelly A. 
Published: March 2022

AbstractCompassionate love is beneficial in a variety of domains, including in education, health, and law, as well as in people’s personal lives. The topic of compassionate love has therefore attracted growing interest from researchers interested in its psychological and social dimensions. Given the importance of compassion to the education and health sectors, and the expansion of these sectors in Iran, this paper aims to provide Persian (Farsi) speaking practitioners and researchers with an effective instrument for measuring compassion. As such, the authors have translated the compassionate love for humanity scale-short form (CLS-H-SF) into the Persian language, and assessed the psychometric properties of this instrument among a sample of the Iranian population. A sample of 827 adults (49.9% women and 51.1% men) completed the Persian version of the CLS-H-SF through an online survey. Concurrent validity was assessed using the Persian versions of the positive and negative affect scale, self-esteem scale, and satisfaction with life scale. The CLS-H-SF positively correlated with positive affect, self-esteem and life satisfaction, and negatively correlated with negative affect. These findings indicate acceptable concurrent validity for the CLS-H-SF. Cronbach’s alpha for the scale was 0.88, indicating good internal consistency between items. A confirmatory factor analysis supported a one-factor model same as the English version of the CLS-H-SF. The findings of this study showed the Persian version of CLS-H-SF had acceptable validity and reliability in assessing compassionate love for humanity in Iranian adults.
Flexible material formulations for 3D printing of ordered porous beds with applications in bioprocess engineering
Authors: Dimartino Simone , Galindo-Rodriguez Giuseppe Rafael , Simon Ursula , Conti Mariachiara , Sarwar M. Sulaiman , Athi Narayanan Selva Manikandan , Jiang Qihao , Christofi Nick 
Published: March 2022

Abstract
Background
3D printing is revolutioning many industrial sectors and has the potential to enhance also the biotechnology and bioprocessing fields. Here, we propose a new flexible material formulation to 3D print support matrices with complex, perfectly ordered morphology and with tuneable properties to suit a range of applications in bioprocess engineering.

Findings
Supports were fabricated using functional monomers as the key ingredients, enabling matrices with bespoke chemistry, such as charged groups, chemical moieties for further functionalization, and hydrophobic/hydrophilic groups. Other ingredients, e.g. crosslinkers and porogens, can be employed to fabricate supports with diverse characteristics of their porous network, providing an opportunity to further regulate the mechanical and mass transfer properties of the supports. Through this approach, we fabricated and demonstrated the operation of Schoen gyroid columns with (I) positive and negative charges for ion exchange chromatography, (II) enzyme bioreactors with immobilized trypsin to catalyse hydrolysis, and (III) bacterial biofilm bioreactors for fuel desulphurization.

Conclusions
This study demonstrates a simple, cost-effective, and flexible fabrication of customized 3D printed supports for different biotechnology and bioengineering applications.
Work histories and provision of grandparental childcare among Italian older women
Authors: Zanasi Francesca , Arpino Bruno , Pirani Elena , Bordone Valeria 
Published: March 2022

AbstractThis work investigates the link between grandmothers’ participation in the labour market during adult life (between ages 18 and 49) and their provision of grandparental childcare later in life. Our contribution is twofold. First, we consider the Italian case, that despite its reliance on informal care has been under-researched. Second, we test two contrasting arguments on the association between grandchild care provision and grandmother’s work histories. On the one hand, lifelong homemakers could be more family-oriented and more likely to provide grandchild care in later life. On the other hand, ever-employed grandmothers could be more likely to have employed daughters and provide grandchild care to support their working careers. With data from the Multipurpose surveys on Families and Social Subjects (2003, 2009, 2016), we estimate logistic regression models, considering various specifications of grandparental childcare, and measuring labour market attachment in three different ways (having ever worked, length of working career, employment interruptions for family reasons). Results show a dualism between grandmothers who ever worked and those who never did, with the former more likely to provide grandparental childcare, especially when parents are at work. Grandmothers who worked only a few years are more similar, in terms of grandchild care provision, to those who worked throughout their life, than to lifelong homemakers. This association is stronger in the South and North-West of Italy. Overall, we showed that care responsibilities are inextricable from labour market participation, as grandmothers who already juggled family and work are those supporting the most their adult children’s work–family reconciliation.
Percutaneous creation of direct intrahepatic portosystemic shunts – an alternative for failed TIPS creation
Authors: Mostafa Karim , Trentmann Jens , Andersson Julian , Günther Rainer , Braun Felix , Schäfer Philipp Jost 
Published: March 2022

Abstract
Introduction
Direct intrahepatic portosystemic shunt creation is a feasible and safe alternative for transjugular intrahepatic portosystemic shunt creation. It needs equipment like endovascular ultrasound with restricted availability. We performed the procedure percutaneously with a common interventional armamentarium to make it more feasible.

Methods
Retrospective analysis of 8 percutaneous DIPS insertions between 2016 and 2020.

Results
The procedure was successful in 8/8 patients. There was no short-term death reported within 30 days. The longest reported patency is 5 years.

Conclusion
Percutaneous DIPS creation is a feasible alternative for failed TIPS. Percutaneously the procedure can be completed faster than conventional DIPS using only minimal puncture equipment.

Level of evidence
Level 4, Case Series.
Differential expression of microRNAs targeting genes associated with the development of high-grade gliomas
Authors: Kit Oleg I. , Pushkin Anton A. , Alliluyev Ilya A. , Timoshkina Nataliya N. , Gvaldin Dmitry Y. , Rostorguev Eduard E. , Kuznetsova Nataliya S. 
Published: March 2022

Abstract
Background
Highly malignant high-grade gliomas are tumors of the central nervous system (CNS). They are solid tumors arising from transformed cells of the brain and/or the spinal cord. In recent years, the expression of genes and regulating miRNAs in glial brain tumors has been actively studied. The present study is devoted to assessing the expression levels of miR-215-5p, miR-22-3p, miR-122-5p, miR-107, miR-324-5p, miR-34a-5p, miR-155. -5p, miR-21-5p, miR-497-5p, miR-330-3p, miR-146a-5p, miR-92a-1-5p, miR-326 and target genes EGFR, SMAD4, SMAD7, SMO, NOTCH1, NOTCH2, HIF1A, EGLIN1/3, KDM1B, KDM1A, MSI1, MSI2, TET1 in high-grade glioma tissues.

Results
As a result of the analysis of the levels of relative expression of the studied genes, there are significant changes (p < 0.05) in tumor tissue for genes: EGFR, SMAD4, SMAD7, SMO, HIF1A, EGLN1/3. We obtained data on a significant change (p < 0.05) in the levels of relative expression for microRNA: hsa-miR-215-5p, hsa-miR-22-3p, hsa-miR-122-5p, hsa-miR-107, hsa-miR-324-5p, hsa-miR-155-5p, hsa-miR-21-5p, hsa-miR-330-3p, hsa-miR-326. Data on the association of overall survival in patients with high-grade glioma and the level of relative expression of the EGFR and HIF1A genes were obtained. The obtained data demonstrate the association of overall survival of patients with high-grade glioma and the level of relative expression of EGFR, HIF1A and hsa-miR-22-3p, hsa-miR-107 and hsa-miR-330-3p.

Conclusions
The obtained data on the expression of genes and microRNAs expand the understanding of the biology of the development of high-grade glial tumors. These data demonstrate new potential therapeutic and prognostic goals in high-grade gliomas.
Factors affecting performance improvement of the metro system in cities
Authors: Aboul-Atta Tarek Abdel-latif , Elmaraghy Sally Bahaa eldin 
Published: March 2022

AbstractThe transportation sector is considered one of the most important sectors affecting the planning and development of cities. It is the responsible sector for traffic and transport inter- and intra-cities through the mass transit systems, which reflect the civilization, urban, economic, and social levels of cities. The importance of this study lies in studying the most important mass transit systems, namely the metro system, as stated unanimously by transport experts and urban planners. It is characterized by speed, safety, and punctuality. It avoids bus drawbacks such as slowness and mixing with other types of traffic. This research aims to find a set of criteria that contribute to improving metro performance and increasing its efficiency. In this paper, some standards were collected from 29 countries with metro systems that are considered successful as they meet the needs of their communities. Conducting the principal component analysis (PCA) and multiple regression analysis (MRA) has produced three mathematical equations to explain the impact of these standards in improving the performance and efficiency of the metro system. The results showed that there is no one set of specific standards among the countries around the world that could be sufficient to rely on to monitor and evaluate metro system performance, which requires further studying and research in this area.
Coupling MCNP6/ANSYS codes to calculate axial temperature and power distribution in a VVER-1000 fuel assembly
Authors: Refeat Riham M. , Refaey Ahmed M. , Abdel-Latif Salwa H. 
Published: March 2022

Abstract
The precise simulation of the reactor core either in steady state or during transients is very important for the safety assessment of nuclear power plants. This requires accurate determination of the parameters that influence the reactor operation. Coupling neutronic and thermal hydraulic schemes are developed to calculate these parameters. In the present paper, a coupling scheme between MCNP6 and ANSYS-FLUENT17.2 codes is proposed to obtain accurate radial and axial temperature distribution and hence pin power distribution for VVER-1000 fuel assembly. The Performance of the developed coupling scheme is investigated in steady state calculations. An iterative process is associated with the exchange of data between codes to meet the convergence criteria. The results obtained demonstrate that the proposed coupling scheme is able to simulate the VVER-1000 fuel assembly accurately. It gives information about thermal and neutronic behavior of the assembly and allows the feedback effects to be accurately modeled. This work is a step forward to establish a consistent methodology to be used in transient calculations.
Elementos asociados al idioma mapuzungun que facilitan y/u obstaculizan el proceso de aprendizaje del idioma inglés en estudiantes de origen mapuche
Authors: Del Valle Rojas Juan Alfredo , Soto Vallejos César Eduardo , Sandoval Tripailaf José Luis , Otárola Rodríguez Joaquín Eduardo , Valdés Guzmán Misael Andrés , Sanhueza Rodríguez Harold Hernán 
Published: March 2022

El objetivo de esta investigación es determinar cuáles son los elementos asociados al idioma mapuzungun que facilitan u obstaculizan el aprendizaje del idioma inglés. En estesentido, son diversos los factores que influyen en el aprendizaje del inglés como un tercer idioma. En relación a los elementos ligados a la cultura mapuche, se encontraron elementos que pudieron haber facilitado y obstaculizado el aprendizaje del inglés. Los hallazgos permiten establecer que el elemento asociado al mapuzungun que facilitó el aprendizaje del inglés en los participantes es la Transferencia Lingüística, ya que este factor se identificó en cuatro de los seis casos. Ellos señalaron que al haber elementos parecidosentre los dos idiomas, aquello facilitó el proceso de aprendizaje del inglés. Igualmente, hubo otros factores que influyeron positivamente en el proceso de aprendizaje del inglés, tales como la Conciencia Metalingüística y factores socioculturales, los cuales se hallaron en tan sólo un caso. En cuanto a los factores asociados al mapuzungun que obstaculizaron el aprendizaje del inglés, se encontró que en la relación entre la cultura mapuche y occidental, existen elementos que obstaculizaron el proceso de aprendizaje en un participante. Por otra parte, se presentó el caso en el cual la diferencia de origen lingüístico del español, mapuzungun e inglés resultó ser un elemento obstaculizador en el aprendizaje del idiomainglés
Las retransmisiones televisivas como origen de nuevos requerimientos en la organización de los eventos
Authors: Montemayor Ruiz Francisco Javier 
Published: March 2022

La organización de un evento mediático conlleva un complejo diseño. Conjugar las necesidades del responsable de la organización con los requerimientos del organismo encargado de la producción de la señal de televisión no siempre resulta una tarea fácil. La interacción entre los diferentes actores que intervienen en este proceso, el flujo de información en ambas direcciones y la coordinación necesaria para conseguir un consenso, facilitará la hoja de ruta en la consecución de un único objetivo comúnque lleve a conseguir el éxito conjunto. El objetivo de este trabajo pretende analizar el modus operandi que se establece entre el comité organizador y el organismo anfitrión de la retransmisión televisiva, al mismo tiempo que establece la hipótesis de que el responsable de protocolo se configura como aglutinador de todas las facetas en el diseño organizacional y constituye la piedra angular de la puesta en escena del evento y quien, junto a los responsables de las áreas de marketing, comunicación y seguridad, será el encargado de establecer las líneas maestras que servirán de base para crear y esbozar la filosofía de la cobertura televisiva.
Análisis del branded content en televisión: estudio de casos españoles
Authors: Castelló Martínez Araceli , Del Pino Romero Cristina 
Published: March 2022

El branded content se ha popularizado como formato de comunicación corporativa y publicitaria alternativa a las acciones comunicacionales tradicionales. El presentetrabajo analiza el uso del branded content por parte de los anunciantes españoles en el medio televisión, con el fin de identificar las características de la aplicación de estatécnica al principal medio en inversión publicitaria en España. La metodología empleada se basa en el estudio de casos, analizando para cada uno de ellos una serie de variables previamente definidas. Los resultados muestran el carácter de utilidad y servicio que, en su mayoría, tienen las acciones de branded content difundidas en el medio televisión, ya que ofrecen información de interés para el ciudadano, como consejos y tutoriales, con un mensaje centrado en el destinatario, y transmitiendo a través de los contenidos los valores de la marca. Como conclusión, podemos destacar la transmedialidad que caracteriza a las acciones de branded ontent televisivas, puesto que la conversación entre marca y usuario sobre la temática tratada en estos espacios continúa en los medios sociales, a través de la presencia de los programas en plataformas como Twitter.
Social Media en el sector del enoturismo
Authors: Matellanes Lazo Mónica 
Published: March 2022

Numerosas ciudades en España han visto ya las ventajas que reportan las actividades enológicas. Castilla y León se intenta posicionar como una comunidad ideal para el destino enoturístico, cultural y para la realización de eventos.La investigación que se muestra pretende dar a conocer el mundo del enoturismo y acercarlo a un mayor número de personas de forma llamativa e interactiva a través de la Comunicación online. Se trata de valorar la comunidad de Castilla y León como destino enoturístico a nivel nacional y mundial. Para ello se ha contactado con profesionales del sector para que ofrezcan sus opiniones y argumentaciones justificadas sobre la gestión de la Comunicación online en las bodegas de Castilla y León. Los resultados afirman que Internet y los Social Media son buenos para comunicar la cultura del vino.
La entrevista periodística como paradigma de un género dialógico: estudio del léxico en la prensa española
Authors: Oliva Marañón Carlos 
Published: March 2022

La entrevista periodística constituye un fenómeno social contemporáneo caracterizado por el hecho de que un mensaje público es dirigido de forma indirecta a unos destinatarios dispares a través de los medios de comunicación. En este estudio se aborda la investigación del léxico de la entrevista periodística en la prensa española durante los años 2008 y 2009. Se estudian los antecedentes históricos de este género, sus definiciones, sus técnicas, la relación entre entrevistador y entrevistado y la ética profesional del periodista. Se ha seleccionado un conjunto de entrevistas publicadas en diarios de tirada nacional para investigar los diferentes tipos de lenguajes. Se constata el uso masivo del lenguaje coloquial, la Retórica, la presencia del lenguaje violento y la utilización de tópicos. Curiosidad, tolerancia, cautela, dominio del lenguaje, capacidad para escuchar y la combinación de técnicas cuantitativas y cualitativas son las aptitudes deseables en un periodista para realizar entrevistas con el máximo rigor.
Presencia de la información especializada en defensa en la red social Twitter. Cuentas oficiales de Twitter del Ministerio de Defensa y organismos militares, cuentas de periodistas especializados y cuentas de ciudadanos
Authors: De Ramón Carrión Manuel 
Published: March 2022

Aunque con mayor retraso que en otros países de la OTAN y del resto de Occidente, las fuentes oficiales de la Defensa española han empezado ya a transmitir noticias a través de la Red Social Twitter y otras. Estas cuentas oficiales han llegado cuando los periodistas especializados en Defensa y otros ciudadanos hacía tiempo que estaban usando las redessociales. Sin embargo, a pesar del retraso, las fuentes oficiales de Defensa han convertido ya Twitter en un importante canal para difundir sus "flashes". El primer caso destacado se produjo en febrero y marzo de 2013, cuando la cuenta @Defensagob anunció que las tropas españolas habían comenzado el repliegue en algunas posiciones de Afganistán. El anuncio sirvió de aviso para todos los periodistas especializados en Defensa, pero también llegó directamente a todos los ciudadanos que siguen la cuenta oficial. Un claro caso "puenteo" del segundo eslabón comunicativo de la Cadena de la Comunicación (la Prensa) que anticipa el riesgo de que algún día las fuentes oficiales se conviertan en emisores directos de mensajes al tercer eslabón (el Público).
Approach for Smart Use of Wastes and Biofuels
Authors: De Simio Luigi , Iannaccone Sabato 
Published: March 2022

The urgent need to reduce greenhouse gas emissions by gradually abandoning fossil fuel sources is required due to climate-changing emergencies. Employing as much as possible renewable energy, in any form and any field, together with a reduction of per capita energy need, can reduce this tendency and contrast the catastrophic consequence of our planet temperature increasing. In this scenario, biofuels production, together with reuse and recycling represent a correct strategy to contrast environmental degradation. Biofuel has been the subject of great interest over the past decade. Their development from the first to the fourth generation has led to significant improvements in the production cycles and extended the interest in new resources. The availability of different choices could permit to use always the best solution to maximize the result.
In this paper, the different biofuel generations are presented with the aim of highlighting strengths and weaknesses to identify a smart approach to energy conversion and land utilization. Even today the first-generation biofuels are the most widespread, while second-generation gives a small contribution, with a low replacement share of fossil fuels. Land use and competition with other human necessities are the most relevant constraints in this evaluation. In general, the production of gaseous fuels requires less energy than liquid for both the first as well as second-generation technologies. When considering gaseous options, biomethane should be preferred for convenient energy balance in the productive process and when biogas cannot be directly employed. Moreover, biomethane gives the possibility to be added to the existing gas network. The new third and fourth-generation technologies could allow a considerable efficiency increase while reducing the problem of the biofuel productive chain.