bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibody response after first and second BNT162b2 vaccination to predict the need for subsequent injections in nursing home residents
Authors: Tuaillon Edouard , Pisoni Amandine , Veyrenche Nicolas , Rafasse Sophia , Niel Clémence , Gros Nathalie , Muriaux Delphine , Picot Marie-Christine , Aouinti Safa , Van de Perre Philippe , Bousquet Jean , Blain Hubert 
Published: August 2022

AbstractWe explored antibody response after first and second BNT162b2 vaccinations, to predict the need for subsequent injections in nursing home (NH) residents. 369 NH residents were tested for IgG against SARS-CoV-2 Receptor-Binding Domain (RBD-IgG) and nucleoprotein-IgG (SARS-CoV-2 IgG II Quant and SARS-CoV-2 IgG Alinity assays, Abbott Diagnostics). In NH residents with prior SARS-CoV-2 infection, the first dose elicited high RBD-IgG levels (≥ 4160 AU/mL) in 99/129 cases (76.9%), with no additional antibody gain after the second dose in 74 cases (74.7%). However, a low RBD-IgG level (< 1050 AU/mL) was observed in 28 (21.7%) residents. The persistence of nucleoprotein-IgG and a longer interval between infection and the first dose were associated with a higher RBD-IgG response (p < 0.0001 and p = 0.0013, respectively). RBD-IgG below 50 AU/mL after the first dose predicted failure to reach the antibody concentration associated with a neutralizing effect after the second dose (≥ 1050 AU/mL). The BNT162b2 vaccine elicited a strong humoral response after the first dose in a majority of NH residents with prior SARS-CoV-2 infection. However, about one quarter of these residents require a second injection. Consideration should be given to immunological monitoring in NH residents to optimize the vaccine response in this vulnerable population.
Effects of Cordyceps militaris fermentation products on reproductive development in juvenile male mice
Authors: Lin Shan , Hsu Wen-Kuang , Tsai Ming-Shiun , Hsu Tai-Hao , Lin Tso-Ching , Su Hong-Lin , Wang Sue-Hong , Jin Dazhi 
Published: August 2022

AbstractCordyceps militaris (CM) is a popular medicinal fungus; however, few studies have focused on its impact on the male reproductive system. We evaluated the effects of CM fermentation products on the reproductive development of juvenile male (JM) mice. Mice were divided into four experimental groups, each fed 5% CM products (weight per weight (w/w) in normal diet): extracellular polysaccharides (EPS), fermentation broth (FB), mycelia (MY), and whole fermentation products (FB plus MY, FBMY) for 28 days, while mice in the control group (CT) were fed a normal diet. Basic body parameters, testicular structure, sperm parameters, and sex hormones concentrations were analyzed. Compared to the CT group, mice in the EPS, MY, and FBMY groups showed a significantly increased mean seminiferous tubule area (p < 0.05), mice in the FB and MY groups had significantly higher sperm concentrations (p < 0.05), and mice in the EPS, FB, and FBMY groups showed significantly increased ratios of motile sperm (p < 0.05). Meanwhile, EPS significantly promoted the ability of JM mice to synthesize testosterone (p < 0.05). Furthermore, all CM products significantly increased the food intake of JM mice (p < 0.05) but did not significantly change their water intake and body weight gain (p > 0.05). In conclusion, CM products, especially EPS, exhibit strong androgen-like activities that can promote male reproductive development.
Si1–xGex anode synthesis on plastic films for flexible rechargeable batteries
Authors: Murata H. , Nozawa K. , Suzuki T. , Kado Y. , Suemasu T. , Toko K. 
Published: August 2022

AbstractSiGe is a promising anode material for replacing graphite in next generation thin-film batteries owing to its high theoretical charge/discharge capacity. Metal-induced layer exchange (LE) is a unique technique used for the low-temperature synthesis of SiGe layers on arbitrary substrates. Here, we demonstrate the synthesis of Si1−xGex (x = 0–1) layers on plastic films using Al-induced LE. The resulting SiGe layers exhibited high electrical conductivity (up to 1200 S cm−1), reflecting the self-organized doping effect of LE. Moreover, the Si1−xGex layer synthesized by the same process was adopted as the anode for the lithium-ion battery. All Si1−xGex anodes showed clear charge/discharge operation and high coulombic efficiency (≥ 97%) after 100 cycles. While the discharge capacities almost reflected the theoretical values at each x at 0.1 C, the capacity degradation with increasing current rate strongly depended on x. Si-rich samples exhibited high initial capacity and low capacity retention, while Ge-rich samples showed contrasting characteristics. In particular, the Si1−xGex layers with x ≥ 0.8 showed excellent current rate performance owing to their high electrical conductivity and low volume expansion, maintaining a high capacity (> 500 mAh g–1) even at a high current rate (10 C). Thus, we revealed the relationship between SiGe composition and anode characteristics for the SiGe layers formed by LE at low temperatures. These results will pave the way for the next generation of flexible batteries based on SiGe anodes.
Novel detection of stem cell niche within the stroma of limbus in the rabbit during postnatal development
Authors: Abdellah Nada , Desoky Sara M. M. El- 
Published: August 2022

AbstractIdentifying and locating stem cell populations in the limbus may lead to developing a cell-based strategy for treating the corneal injury. Therefore, this study was the first to design a follow-up on the microscopical and histomorphometric changes in the rabbit limbus and to localize and demonstrate the limbal stem cell niche during postnatal development. The paraffin sections from the eyes of different postnatal-developmental stages were stained and examined using light microscopy. Furthermore, sections were immunohistologically stained for the epithelial stem cell differentiation marker, cytokeratin-14. Moreover, semithin and ultrathin sections were applied for ultrastructural demonstration of the stem cell niche. This study revealed that the number and thickness of limbal epithelial layers increased with age, whereas the thickness of limbal stroma decreased. Additionally, the immunohistochemical data showed that ck14 staining intensity increased in the limbal region where limbal stem cells reside. The semithin and ultrastructure investigation revealed stem cell clusters within the limbus’s underlying stroma close to the blood and nerve supply and surrounded by telocytes. Conclusively, isolated clusters of limbal epithelial stem cells combined with blood vessels, nerve fibers, and telocytes propose a harmonious microenvironment of a stem cell niche.
Heterogeneous impact of Covid-19 response on tuberculosis burden by age group
Authors: Kim Boyeon , Kang Young Ae , Lee Jeehyun 
Published: August 2022

AbstractApart from the incidence and mortality caused by it, Coronavirus disease (COVID-19) has had a significant impact on other diseases. This study aimed to estimate the influences of COVID-19 pandemic on the incidence of tuberculosis (TB) and the number of TB-associated deaths in Republic of Korea. A dynamic compartment model incorporating age-structure was developed for studying TB transmission and progression using the Korean population data. After calibration with notification of incidence data from South Korea, the TB burden over 6 years (2020–2025) was predicted under the nine different scenarios. Under the scenario of strong social distancing and low-level health service disruption, new TB cases were reduced by 761 after 1 year in comparison to the baseline. However, in the elderly population, social distancing had little impact on TB incidence. On the other hand, the number of TB-related deaths mainly depends on the level of health service disruption for TB care. It was predicted that with a high degree of health service disruption, the number of TB-related deaths would increase up to 155 in 1 year and 80 percent of the TB-related deaths would be in the elderly population. The decrease of tuberculosis incidence is significantly affected by social distancing, which is owing to reduction of contacts. The impact of health service disruption is dominant on TB-related deaths, which occurs mainly in the elderly. It suggests that it is important to monitor TB-related deaths by COVID-19 because the TB burden of the elderly is high in the Republic of Korea.
Deficits in multiple object-tracking and visual attention following mild traumatic brain injury
Authors: Alnawmasi Mohammed M , Khuu Sieu K. 
Published: August 2022

AbstractDifficulty in the ability to allocate and maintain visual attention is frequently reported by patients with traumatic brain injury (TBI). In the present study, we used a multiple object tracking (MOT) task to investigate the degree to which TBI affects the allocation and maintenance of visual attention to multiple moving targets. Fifteen adults with mild TBI and 20 control participants took part in this study. All participants were matched for age, gender, and IQ. The sensitivity and time taken to perform the MOT task were measured for different conditions in which the duration of the tracking, number of target, and distractor dots were systematically varied. When the number of target dots required to be tracked increased, sensitivity in correctly detecting them decreased for both groups but was significantly greater for patients with mild TBI. Similarly, increasing the number of distractor dots had a greater effect on reducing task sensitivity for patients with mild TBI than control participants. Finally, across all conditions, poorer detection performance was observed for patients with mild TBI when the tracking duration was longer compared to control participants. The present study showed that patients with mild TBI have greater deficits (compared to control participants) in their ability to maintain visual attention on tracking multiple moving objects, which was particularly hindered by increased tracking load and distraction.
Adiabatic logic based shift registers for low energy IoT architecture—Design and contemplation
Authors: Sanadhya Minakshi , Kumar Sharma Devendra 
Published: August 2022

AbstractShift register is one of the important components in any digital circuit. By improving the performance of shift register, one can improvise the whole system performance. Shift registers are the basic memory units and data transfer devices in IoT applications. The efficacy of computing devices depends on the performance of arithmetic circuits, including shift registers. Adiabatic logic has been proposed as anew computing platform to develop power‐efficient IoT devices. This paper presents low power adiabatic shift registers. The design of shift registers uses D flipflop, based on DC‐DB PFAL (direct‐current diode based positive feedback adiabatic logic). Performance parameters of the presented circuits are analyzed for transistor count, power dissipation, latency, and PDP (power delay product). Simulations are run for all the presented circuits at 180nm and 45nm technology nodes. It is found that the proposed parallel in parallel out shift register (PIPO) design outperforms with the improvement in PDP as 53%, 53%, and 57% compared to theserial in serial out (SISO), serial in parallel out (SIPO), and parallel inserial out (PISO) shift registers respectively at 100MHz and 45 nm technology node. Further, the proposed PIPO shift register shows improved performance than the other designs in the literature.
Optical gas sensing of sub‐ppm SO2F2 and SOF2 from SF6 decomposition based on photoacoustic spectroscopy
Authors: Zhang Ying , Wang Mingwei , Yu Pengcheng , Liu Zhe 
Published: August 2022

AbstractSF6 has been recognized worldwide as the main insulating gas for Gas‐Insulated Switchgear (GIS). It is often required to accurately and effectively detect typical SF6 decomposition. In this paper, a sub‐ppm‐level SO2F2 and SOF2 gas sensor based on photoacoustic spectroscopy (PAS) is proposed and demonstrated. The steel resonant photoacoustic cell with a resonant frequency of 1750 Hz was designed and fabricated. The harmonic detection technique in wavelength modulation spectroscopy was applied to improve the signal‐to‐noise ratio. A mercury‐cadmium‐telluride photodetector was added in the PAS system to monitor the input optical power, in order to compensate for the errors caused by power fluctuations. SO2F2 and SOF2 were measured by using distributed feedback quantum cascade lasers at 6648 and 7463 nm, respectively. The results show that the proposed sensor performed with favourable linearity within the dynamic range, and reached the minimum detection limit of 0.22 ppm for SO2F2 and 0.28 ppm for SOF2, which indicated its great potential for monitoring the decomposition process of SF6 in GIS.
High metal content of highly accreting quasars: Analysis of an extended sample
Authors: Garnica K. , Negrete C. A. , Marziani P. , Dultzin D. , Śniegowska M. , Panda S. 
Published: August 2022

Context.We present an analysis of UV spectra of quasars at intermediate redshifts believed to belong to the extreme Population A (xA), aimed to estimate the chemical abundances of the broad line emitting gas. We follow the approach described in a previous work, extending the sample to 42 sources.Aim.Our aim is to test the robustness of the analysis carried out previously, as well as to confirm the two most intriguing results of this investigation: evidence of very high solar metallicities and a deviation of the relative abundance of elements with respect to solar values.Methods.The basis of our analysis are multicomponent fits in three regions of the spectra centered at 1900, 1550, and 1400 Å in order to deblend the broad components of AlIIIλ1860, C III]λ1909, CIVλ1549, He IIλ1640, and SiIVλ1397+OIV]λ1402 and their blue excess.Results.By comparing the observed flux ratios of these components with the same ratios predicted by the photoionization codeCLOUDY, we found that the virialized gas (broad components) presents a metallicity (Z) higher than 10Z⊙. For nonvirialized clouds, we derived a lower limit to the metallicity around ∼5Z⊙under the assumption of chemical composition proportional to the solar one, confirming the previous results. We especially relied on the ratios between metal lines and He IIλ1640. This allowed us to confirm systematic differences in the solar-scaled metallicity derived from the lines of Aluminum and Silicon, and of Carbon, with the first being a factor ≈2 higher.Conclusions.For luminous quasars accreting at high rates, highZvalues are likely, butZ-scaled values are affected by the possible pollution due to highly-enriched gas associated with the circumnuclear star formation. The high-Zvalues suggest a complex process involving nuclear and circumnuclear star formation and an interaction between nuclear compact objects and an accretion disk, possibly with the formation of accretion-modified stars.
Zur Geschichte einer speziellen Verbindung von Universitäts-
und Anstaltspsychiatrie (1903–1974)
Authors: Braun Birgit 
Published: August 2022

Zusammenfassung
Einleitung Erst 1974 erfolgte die endgültige Trennung der Erlanger
Universitätspsychiatrie von der Bezirkspsychiatrie. Im vorliegenden
Aufsatz wird die über 70-jährige Geschichte einer speziellen
Verbindung von Universitäts- und Anstaltspsychiatrie näher
analysiert.
Methode Relevantes archivarisches Material sowie Primär- und
Sekundärliteratur wurden ausgewertet.
Ergebnisse Obwohl die Universität Erlangen mit Johann Michael
Leupoldts (1794–1874) psychiatrischen Vorlesungen ab 1818 eine
frühe Pflegstätte der Psychiatrie ist, wurde erst 1903 eine
Psychiatrische Klinik gegründet und zwar innerhalb des Verbandes der
Heil- und Pflegeanstalt (HuPflA). Die Klinikpatienten wurden
verwaltungstechnisch als „Anstaltsinsassen“ geführt, die
Klinik hatte keine eigenen Einnahmen. Insbesondere bemerkenswert ist, dass der
Direktor der psychiatrischen Universitätsklinik formal als
„Abteilungsarzt der Anstalt“ betrachtet wurde. Die
Autonomiebestrebungen der universitären Psychiatrie in Erlangen konnten
aufgrund der sozialpolitischen Situation bis zur Mitte der 1970er-Jahre nicht
verwirklicht werden.
Diskussion Neben persönlichen Unstimmigkeiten mag die
vertragsbedingt komplizierte dienstliche Abhängigkeit des
Klinikdirektors vom Anstaltsdirektor die jahrzehntelange
„mésalliance-Tradition“ zwischen Klinikvorstand und
Anstaltsleiter entscheidend mitbedingt haben. Zum regelrechten
öffentlichen Skandal gereichte 1978 eine Dienstaufsichtsbeschwerde bei
der Regierung von Mittelfranken wegen mangelnder Sicherung von
Patientenunterlagen und Medikamenten im Rahmen des Umzuges der ehemaligen
Anstaltsabteilungen in den Bezirkskrankenhaus-Neubau am Europakanal. Diesen
Vorgängen mag das Fehlen der Trennungsunterlagen zwischen
Universität und Bezirk geschuldet sein.
Ausblick In gewandelter Form besteht gegenwärtig eine
Zusammenarbeit der beiden Erlanger psychiatrischen Institutionen. So kann die
Psychiatrische Klinik stationäre Patienten des Bezirkskrankenhauses am
Europakanal in wissenschaftliche Untersuchungen einbeziehen.
Darüberhinausgehend kann der vorliegende Aufsatz die aktuelle Diskussion
um eine Form der bedarfsangepassten integrierten Patientenversorgung in
Zusammenschluss von Universitäts- und Anstaltspsychiatrie bereichern und
aufzeigen, wie eine interinstitutionelle psychiatrische Therapie gelingen
kann.
Effect of individual characteristics and aerobic training on the %HRR‐%V̇O2R relationship
Authors: Ferri Marini Carlo , Sisti Davide , Skinner James S. , Sarzynski Mark A. , Bouchard Claude , Amatori Stefano , Rocchi Marco B. L. , Piccoli Giovanni , Stocchi Vilberto , Federici Ario , Lucertini Francesco 
Published: August 2022

ABSTRACTThis study aimed to assess if, during incremental exercise, considering individual characteristics can make the relationship between the percentages of heart rate (HRR) and oxygen uptake (V̇O2R) reserve either 1:1 or more accurate. Cycle ergometer data of the maximal incremental exercise tests performed by 450 healthy and sedentary participants (17–66 years) of the HERITAGE Family Study, grouped for sex, ethnicity, age, body fat, resting HR, and V̇O2max, were used to calculate the individual linear regressions between %HRR and %V̇O2R. The mean slope and intercept of the individual linear regressions of each subgroup were compared with 1 and 0 (identity line), respectively, using Hotelling tests followed by post‐hoc one‐sample t‐tests. Two multiple linear regressions were also performed, using either the slopes or intercepts of the individual linear regressions as dependent variables and sex, age, resting HR, and V̇O2max as independent variables. The mean %HRR‐%V̇O2R relationships of all subgroups differed from the identity line. Moreover, individual linear regression intercepts (8.9 ± 16.0) and slopes (0.971 ± 0.190) changed (p < 0.001) after 20 weeks of aerobic training (13.1 ± 11.1 and 0.891 ± 0.122). The multiple linear regressions could explain only 3.8% and 1.3% of the variance in the intercepts and slopes, whose variability remained high (standard error of estimate of 15.8 and 0.189). In conclusion, the %HRR‐%V̇O2R relationship differs from the identity line regardless of individual characteristics and their difference increased after aerobic training. Moreover, due to the high interindividual variability, using a single equation for the whole population seems not suitable for representing the %HRR‐%V̇O2R relationship of a given subject, even when several individual characteristics are considered.
Dependence of the conductivity of two-dimensional site percolation network on the length-ratio of conducting paths to all bonds: the viewpoint of effective path theory
Authors: Zeng Jianwen , Wang Yu , Zheng Xiaojuan , Zhou Conghua 
Published: August 2022

Abstract
Previous studies have found that the network conductivity of 2-dimensional disordered nanowire networks (DNNs) scaled linearly with the length-ratio of conducting-paths to all nanowires. To show the universality of this rule, the conducting behavior of a 2-dimensional site percolation problem is studied in this article with the assistance of a Monte Carlo based numerical simulation. It is observed that, as the existence probability of site increases in the 2-dimensional site percolated network, more conducting-paths are formed, and the network becomes more conductive. After correlating the site-percolated lattice to DNNs, the normalized network conductivity is observed to scale linearly with the length-ratio of conducting-paths to all bonds, which could be well described by the linear formula using a slope of 2 and an incept of 0.5. As a result, the length-ratio of conducting-paths could again serve as a basic topological parameter in describing the conducting behavior of 2-dimensional site percolation networks. Such universality enables the definition of an ‘effective path theory’, in which the normalized network conductivity scales linearly with the length-ratio of conducting-paths to all bonds.
Determination of the direct bandgap value in In4Se3 thin films
Authors: de Brucker L , Moret M , Gil B , Desrat W 
Published: August 2022

Abstract
The value and the nature of the bandgap of In4Se3 are still not well defined, with a large spread of the experimental data between 0.42 and 1.68 eV and an uncertain nature, predicted to be indirect by ab initio band structure calculations. Here we report on the optical transmission and photoluminescence (PL) performed in In4Se3 thin films grown by coevaporation on (0001)-oriented sapphire wafers. The quality of the polycrystalline layers allows the first detection of the excitonic-like transition in the optical absorption of this compound at low temperature. The PL detected under weak laser excitation shows a bound exciton emission at 0.75 eV. Strong laser irradiation reveals a quadratic dependence of the PL intensity on the optical excitation, which demonstrates a stimulated emission at 0.79 eV in relation with an exciton–exciton scattering process. On the basis of a reasonable estimate of the exciton energy, equal to

10
−
15

meV, we evaluate the direct bandgap of In4Se3 to

0.82
±
0.01

eV at low temperature.
Intravital optical imaging for immune cell tracking after photoimmunotherapy with plasmonic gold nanostars
Authors: Chorniak Ericka , Liu Yang , Odion Ren , Etienne Wiguins , Canning Aidan , Nair Smita K , Maccarini Paolo , Palmer Gregory M , Inman Brant A , Vo-Dinh Tuan 
Published: August 2022

Abstract
Bladder cancer has been ranked as one of the most commonly occurring cancers in men and women with approximately half of the diagnoses being the late stage and/or metastatic diseases. We have developed a novel cancer treatment by combining gold nanostar-mediated photothermal therapy with checkpoint inhibitor immunotherapy to treat bladder cancer. Experiment results with a murine animal model demonstrated that our developed photoimmunotherapy therapy is more efficacious than any individual studied treatment. In addition, we used intravital optical imaging with a dorsal skinfold window chamber animal model to study immune responses and immune cell accumulation in a distant tumor following our photoimmunotherapy. The mice used have the CX3CR1-GFP receptor on monocytes, natural killer cells, and dendritic cells allowing us to dynamically track their presence by fluorescence imaging. Our proof-of-principle study results showed that the photoimmunotherapy triggered anti-cancer immune responses to generate anti-cancer immune cells which accumulate in metastatic tumors. Our study results illustrate that intravital optical imaging is an efficient and versatile tool to investigate immune responses and mechanisms of photoimmunotherapy in future studies.