bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of returnee executives and managerial discretion on excess perquisite consumption
Authors: Ren Ge , Zeng Ping , Zhong Xi 
Published: October 2022

AbstractThis study examines the impact of returnee executives on top management teams' (TMTs') unethical management behavior (e.g., excess perquisite consumption). Synthesizing insights from upper echelons theory and the psychological entitlement literature, this study proposes that returnee executives cause TMTs to generate a high degree of psychological entitlement, which subsequently leads to a high degree of excess perquisite consumption in their firms. In addition, this study proposes that returnee chief executive officers, product diversification, and regional institutional development moderate the aforementioned relationships by influencing managerial discretion. This study provides empirical evidence for the above view using a dataset that was constructed based on 1960 listed Chinese manufacturing companies from 2010 to 2019. From a psychological entitlement perspective, this study confirms, for the first time, that the introduction of returnee executives may have unintended negative consequences, for example, in promoting the excess perquisite consumption activities of TMTs.
circTOP2A functions as a ceRNA to promote glioma progression by upregulating RPN2
Authors: Sun Jikui , Wang Jinhuan , Li Meng , Li Shengjie , Li Hanyun , Lu Yan , Li Feng , Xin Tao , Jin Feng 
Published: October 2022

AbstractCompeting endogenous RNA (ceRNA)‐mediated signaling pathway dysregulation provides great insight into comprehensively understanding the molecular mechanism and combined targeted therapy for glioblastoma. circRNA is characterized by high stability, tissue/developmental stage‐specific expression and abundance in brain and plays significant roles in the initiation and progression of cancer. Our previous published data have demonstrated that RPN2 was significantly upregulated in glioma and promoted tumor progression via the activation of the Wnt/β‐catenin pathway. Furthermore, we proved that miR‐422a regulated the Wnt/β‐catenin signaling pathway by directly targeting RPN2. In this study, based on the glioblastoma microarray profiles, we identified the upstream circTOP2A, which completely bound to miR‐422a and was co‐expressed with the RPN2. circTOP2A was significantly overexpressed in glioma and conferred a poor prognosis. circTOP2A could regulate RPN2 expression by sponging miR‐422a, verified by western blot, dual‐luciferase reporter gene assay, and RNA pull‐down assay. Functional assays including CCK8, transwell and FITC‐annexin V were performed to explore the RPN2‐mediated role of the circTOP2A effect on the glioma malignant phenotype. Additionally, TOP/FOP and immunofluorescence analysis were used to confirm that sh‐circTOP2A could suppress the Wnt/β‐catenin pathway partly through RPN2. Finally, a tumor xenograft model was applied to validate the biological function of circTOP2A in vivo. Taken together, our findings reveal the critical role of circTOP2A in promoting glioma proliferation and invasion via a ceRNA mechanism and provide an exploitable biomarker and therapeutic target for glioma patients.
A monolateral pigmented lesion of the nipple
Authors: Volontè Martina , Barruscotti Stefania , Feltri Monica , Brazzelli Valeria , Tomasini Carlo Francesco , Vassallo Camilla 
Published: October 2022

Abstract
Pigmented mammary Paget's disease is a very rare variant of mammary Paget's disease linked to an underlying carcinoma in almost all cases. We present the case of a 62-year-old female patient who came to our attention for the evaluation of a monolateral asymptomatic pigmented lesion of the right nipple, which turned out to be a pigmented mammary Paget's disease unassociated to an underlying malignancy – an extremely rare entity only anecdotally reported in literature. The two main peculiarities of our patient's lesion, the importance of immunohistochemistry in the differential diagnosis and the theories on its pathogenesis are discussed. Further studies are necessary to establish the best treatment options.
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Carbohydrate antigen 19‐9 plus carcinoembryonic antigen for prognosis in colorectal cancer: An observational study
Authors: Lee Jong O. , Kim Minjung , Lee Jeong‐Hwan , Kim Youngmin , Lim Han‐Ki , Kwon Yoon‐Hye , Shin Rumi , Park Ji W. , Ryoo Seung‐Bum , Park Kyu J. , Jeong Seung‐Yong 
Published: October 2022

AbstractAimCarcinoembryonic antigen (CEA) is a primary prognostic marker and can detect colorectal cancer (CRC) recurrence; however, it has low sensitivity. Carbohydrate antigen 19‐9 (CA 19‐9) can be used as a supplemental tumour marker along with CEA. The purpose of this study was to determine whether preoperative CA 19‐9 added to CEA helped predict long‐term prognosis and whether follow‐up CA 19‐9 added to CEA had additional benefits in diagnosing the recurrence of CRC.MethodWe retrospectively assessed patients who underwent surgery for primary CRC between January 2004 and December 2015 at Seoul National University Hospital. Data on demographics, preoperative and follow‐up CEA and CA 19‐9 levels, recurrence and survival were obtained and analysed with respect to tumour marker levels to ascertain their prognostic and diagnostic values.ResultsA total of 4972 and 1530 patients were included to analyse preoperative and follow‐up tumour marker levels, respectively. The 5‐year relapse‐free survival rates were 72.2% ± 0.8%, 52.5% ± 2.2%, 55.5% ± 3.2% and 32.1% ± 2.3% in the normal CEA and CA 19‐9, high CEA, high CA 19‐9, and high CEA and high CA 19‐9 groups, respectively (all P < 0.001). Patients whose elevated CEA or CA 19‐9 levels reduced to normal levels had better survival outcomes than those with postoperatively elevated levels. Elevated follow‐up CA 19‐9 and CEA levels were related to higher incidences of distant metastasis (CA 19‐9, 14.0% vs. 23.1%, P = 0.004; CEA, 12.6% vs. 30.1%, P < 0.001) but not to local recurrence. Combined follow‐up CEA and CA 19‐9 increased the sensitivity for recurrence to 31.4%, with a 5% difference from the sensitivity of CEA alone. In the subgroup with high preoperative CA 19‐9 levels, sensitivity increased by 18.2% overall.ConclusionCA 19‐9 is a valuable prognostic and diagnostic marker for CRC when used adjunctively with CEA and can be a supplementary marker with CEA to improve sensitivity, especially with elevated preoperative CA 19‐9.
Coronary artery calcium score and its association with stroke: A systematic review and meta‐analysis
Authors: Kwok Chun Shing , Bennett Sadie , Lip Gregory Y. H. 
Published: October 2022

AbstractBackgroundThe relationship between coronary artery calcium (CAC) score and incident stroke is controversial.MethodsWe conducted a systematic review of the literature evaluating CAC score and incident stroke. A search of MEDLINE and EMBASE was performed, and data were extracted from relevant studies. Statistical pooling with random‐effects meta‐analysis was undertaken to evaluate the risk of incident stroke with any CAC vs. no CAC, 1–100 CAC vs. no CAC, and >100 CAC vs. no CAC.ResultsData from nine different cohort studies from the United States and Europe with a total of 61,096 patients were included in this review. The mean age of patients in the studies ranged from 44 to 69 years, and follow‐up duration ranged from a median of 5.5 years to 12.3 years. The crude stroke event varied from 1.6% to 9.5%. Meta‐analysis of risk of incident stroke with any vs. no CAC (RR 1.70 95% CI 0.87–3.31, I2 = 95%) and for CAC 1–100 vs. no CAC (RR 1.54 95% CI 0.75–3.17, I2 = 93%) was not statistically significant. For CAC >100, the risk of incident stroke was significantly higher compared with no CAC (RR 2.61 95% CI 1.51–4.52, I2 = 89%). When one study which included only young adults was excluded, there was significant increase in risk of incident stroke with all categories of CAC.ConclusionsThere is an association between high CAC score and incident stroke, but more studies are needed to determine how patients with incidental CAC should be managed from the perspective of stroke prevention.
European Soil Data Centre 2.0: Soil data and knowledge in support of the EU policies
Authors: Panagos Panos , Van Liedekerke Marc , Borrelli Pasquale , Köninger Julia , Ballabio Cristiano , Orgiazzi Alberto , Lugato Emanuele , Liakos Leonidas , Hervas Javier , Jones Arwyn , Montanarella Luca 
Published: October 2022

AbstractThe European Soil Data Centre (ESDAC), hosted by the European Commission's Joint Research Centre (JRC), is the focal point for soil data, support to policy making and awareness raising for the European Union (EU). Established in 2006 to provide harmonised soil‐related information for the EU Member States, and ESDAC currently hosts 88 datasets, 6000 maps, six atlases, 500 scientific publications, and a copious amount of soil‐related material. Through its data repository publishing activity, ESDAC has licensed over 50,000 datasets during the past 15 years; 8500 of them in 2021 alone. It has published 140 monthly newsletters and is followed by more than 12,000 subscribed users, which receive regular updates. This article addresses the use, usability, and usefulness of ESDAC. About 75% of the ESDAC users come from academia and the research community while the remaining 25% includes public administration (at EU, national, regional, and local level) and the private sector. In addition, we provide some insights of the datasets evaluation and how they have been developed. The general ESDAC vision is to provide evidence underlying EU soil‐relevant policies and to facilitate the access to relevant data for research. ESDAC is an integral part of the recently established European Union Soil Observatory (EUSO), with a target to have an even stronger role in supporting EU and regional policies.Highlights
ESDAC is a central place from where to find European wide relevant soil data.
ESDAC is an integral part of the EU Soil Observatory in creating data and knowledge for policy support.
The ESDAC website shows a high volume of traffic; 10,000 of user licenses are granted per year.
ESDAC key success: open access data policy, documentation, operational helpdesk and regular updates.
Land use and land cover changes in coastal and inland wetlands cause soil carbon and nitrogen loss
Authors: Tan Lishan , Ge Zhenming , Ji Yuhuang , Lai Derrick Y. F. , Temmerman Stijn , Li Shihua , Li Xiuzhen , Tang Jianwu 
Published: October 2022

AbstractAimNatural wetlands are widely considered important for mitigation of climate change, but they have been impacted by land use and land cover change (LULCC), often resulting in ecosystem degradation and significant changes in soil carbon (C) and nitrogen (N) dynamics. However, the impact of various LULCC types on wetland soil C and N dynamics remains unclear.LocationGlobal.Time period1982–2021.Major taxa studiedWetland.MethodsWe present a global meta‐analysis using a database of 487 sites compiled from the literature, demonstrating the response of soil C and N concentrations and stocks in coastal wetlands, riparian wetlands and peatlands to various types of LULCCs, including agricultural lands, drained wetlands, aquaculture ponds, pastures and constructed wetlands.ResultsThe conversion of coastal wetlands, riparian wetlands and peatlands to most LULCC types decreased the mean soil C and N concentrations and stocks by 17.8 ± 10.3, 25.3 ± 13.4 and 23.2 ± 6.3%, respectively. The loss of wetland soil C owing to LULCC is estimated to cause a potential CO2 emission of 1.8–22.8 Mg CO2 equivalent emission/ha/year, except for conversion to constructed wetlands. The soil C and N contents were more sensitive to LULCCs, relative to the stocks. We also found that the patterns of soil C and N variations were closely related to the conversion time since completion of LULCC. After LULCC, the response of soil C and N variables was sensitive to changes in plant biomass, soil water conditions, bulk density, pH and NH4+‐N concentration, with the major controlling factors varying with the conversion age.Main conclusionsOur results highlight the important role of LULCC in triggering soil C and N loss in natural wetlands, which enhances the greenhouse effect. As such, our study calls for sustainable land management strategies aiming at wetland conservation as a powerful tool to mitigate climate warming.
Monochromatic Wave of Fluid Pressure in a Porous Rock
Authors: Li Guangquan , Miao Yifang , Mei Yangming 
Published: October 2022

AbstractFrom the perspective of rock mechanics, transmission of fluid pressure that drives groundwater flow is not instantaneous; instead it is a slow compressional (P) wave in porous rocks saturated with a fluid. In this paper, the approach of monochromatic wave is used to analyze the slow P‐wave. Permeability is derived as a function of the frequency of the wave. The permeability appears to be a complex number which asymptotes to Darcy permeability at the low frequency end but tends to vanish at the high frequency end. With Biot theory, the permeability predicts phase velocity and the quality factor of the monochromatic wave. Using Berea sandstone as an illustrative example, the complex‐number permeability can yield a lower phase velocity (within frequency of 105–108 Hz) and a larger attenuation (for frequency above 106 Hz) than Darcy permeability does. This study extends the recent research of the low‐frequency waves of fluid pressure to the regime of very high frequency.
Myoid gonadal stromal tumours are characterised by recurrent chromosome‐level copy number gains: molecular assessment of a multi‐institutional series
Authors: Collins Katrina , Sholl Lynette M. , Siegmund Stephanie , Dickson Brendan C. , Colecchia Maurizio , Michalová Květoslava , Hwang Michael , Ulbright Thomas M. , Kao Chia‐Sui , van Leenders Geert J.L.H. , Mehta Vikas , Trpkov Kiril , Yilmaz Asli , Cimadamore Alessia , Matoso Andres , Epstein Jonathan I. , Maclean Fiona , Comperat Eva , Anderson William J. , Fletcher Christopher D.M. , Acosta Andrés M. 
Published: October 2022

Myoid gonadal stromal tumours (MGST) represent a rare type of testicular sex cord‐stromal tumour that has recently been recognised as a distinct entity by the World Health Organization (WHO) classification of genitourinary tumours. MGSTs affect adult men and have been reported to behave in an indolent fashion. Histologically, MGSTs are pure spindle cell neoplasms that coexpress SMA and S100 protein. Given that the molecular features of these neoplasms remain largely undescribed, we evaluated a multi‐institutional series of MGSTs using DNA and RNA sequencing. This study included 12 tumours from 12 patients aged 28 to 57 years. Tumour sizes ranged from 0.6 to 4.3 cm. Aggressive histologic features, such as vascular invasion, necrosis, invasive growth, and atypical mitoses were invariably absent. Mitotic activity was low, with a median of less than 1 mitosis per 10 high power fields (HPF; maximum: 3 mitoses per 10 HPF). Molecular analyses did not identify recurrent mutations or gene fusions. All cases with interpretable copy number variant data (9/10 cases sequenced successfully) demonstrated a consistent pattern of chromosome arm‐level and whole‐chromosome‐level copy number gains indicative of ploidy shifts, with recurrent gains involving chromosomes 3, 6, 7, 8, 9, 11, 12, 14q, 15q, 17, 18q, 20, and 21q. Similar findings have also been recognised in pure spindle cell and spindle‐cell predominant sex cord‐stromal tumours without S100 protein expression. MGSTs are characterised by ploidy shifts and may be part of a larger spectrum of spindle cell‐predominant sex cord‐stromal tumours, including cases without S100 protein expression.
Revenue sharing or not? Coordination of the buy‐online‐and‐pickup‐in‐store supply chain
Authors: Peng Yang , Lu Junjie , Cheng Tai Chiu Edwin , Ji Min 
Published: October 2022

AbstractWhile there is much research on coordinating the dual‐channel supply chain using the revenue‐sharing contract, it is unclear if there is a better mechanism design in the buy‐online‐and‐pickup‐in‐store (BOPS) mode. In this channel integration environment, the customer service provided by the bricks‐and‐mortar store is critical to the chain's success. Based on a stackable game model, we analyze the contract methods for the cases of revenue sharing and no revenue sharing, where the latter is classified into two types: All the credit goes to the offline or online channel. Focusing on improving consumer service and supply chain performance in the BOPS mode, we observe that revenue sharing is not necessarily the best contract type, while the non‐revenue‐sharing contract of a lump‐sum subsidy plus quantity discount can coordinate the supply chain. We also analyze the impacts of some endogenous parameters and derive the conditions for the equilibrium outcomes. We find that revenue sharing cannot effectively stimulate the offline channel to improve its service effort as the offline channel is more concerned about service cost sharing than revenue sharing. The results are similar to those of revenue allocation to the online or offline channel in the BOPS mode, but the conditions are slightly different. Conducting numerical studies to gain insights from the analytical findings, we find that the subsidy contract is better than the revenue‐sharing approach under various market conditions.
A dual realist review: Compression for leg swelling at the end of life has potential quality of life benefit
Authors: O'Brien Joanna , Dingle Maria 
Published: October 2022

AbstractAimsTo examine the evidence for the use of compression in the general population and determine how far it can be used to inform treatment at the end of life.DesignIn advanced illness, some patients suffer lower limb swelling and its resulting problems. In the general population, compression is used to treat lower limb swelling, but little is known about its use at the end of life. This review is designed to deeply explore the available evidence and identify what is known and areas for further research.Data SourcesFive databases were searched; CINAHL, MEDLINE, Embase, AMED and Cochrane, in November 2021. Reference lists for included studies were hand‐searched. A web search was carried out.Review MethodsTwo parallel realist reviews were performed. The first reviewed the use of compression in the general population. The second explored lower limb swelling at the end of life. Findings were screened using inclusion and exclusion criteria, quality assessed and qualitative and quantitative data extracted.ResultsThe initial searches returned 1179 articles in review one and 839 articles in review two. Following the screening, 10 articles remained in each review for analysis. A programme theory was drawn for each review. The theories had sufficient similarities to allow evidence from the general population to be used to make recommendations for those at the end of life.ImpactPeople with advanced illness and leg swelling suffer physically and psychologically. Compression delivers a reduction in swelling and quality of life benefit in the general population. This study found people with advanced illness may experience the same benefits. A cautious approach should be taken and stockings or adjustable Velcro compression devices (AVCDs) are likely to be the best starter interventions. Existing guidelines should also be consulted. Further research to develop the right intervention in this group is needed.
Peripheral levels of monocytic myeloid‐derived suppressive cells before and after first induction predict relapse and survivals in AML patients
Authors: Peterlin Pierre , Debord Camille , Eveillard Marion , Garnier Alice , Le Bourgeois Amandine , Guillaume Thierry , Jullien Maxime , Béné Marie C. , Chevallier Patrice 
Published: October 2022

AbstractMyeloid Derived Suppressive Cells (MDSC) are capable to suppress innate and adaptive immune responses, thus favouring solid cancer progression. However, little is known about the role of MDSC in acute myeloid leukaemia (AML). In this monocentric prospective study, 73 adult AML patients, eligible for first‐line intensive chemotherapy, were included with the aim to study the influence on long‐term outcomes of peripheral blood (PB) levels of monocytic (M) MDSC (M‐MDSC) assessed by flow cytometry. A percentage of peripheral M‐MDSC higher than 0.55% of leukocytes at diagnosis and a decrease of M‐MDSC% after induction came out both as independent negative prognostic factors for leukaemia‐free and overall survival.
Recent progression and future perspectives in cotton genomic breeding
Authors: Yang Zhaoen , Gao Chenxu , Zhang Yihao , Yan Qingdi , Hu Wei , Yang Lan , Wang Zhi , Li Fuguang 
Published: October 2022

AbstractUpland cotton is an important global cash crop for its long seed fibers and high edible oil and protein content. Progress in cotton genomics promotes the advancement of cotton genetics, evolutionary studies, functional genetics, and breeding, and has ushered cotton research and breeding into a new era. Here, we summarize high‐impact genomics studies for cotton from the last 10 years. The diploid Gossypium arboreum and allotetraploid Gossypium hirsutum are the main focus of most genetic and genomic studies. We next review recent progress in cotton molecular biology and genetics, which builds on cotton genome sequencing efforts, population studies, and functional genomics, to provide insights into the mechanisms shaping abiotic and biotic stress tolerance, plant architecture, seed oil content, and fiber development. We also suggest the application of novel technologies and strategies to facilitate genome‐based crop breeding. Explosive growth in the amount of novel genomic data, identified genes, gene modules, and pathways is now enabling researchers to utilize multidisciplinary genomics‐enabled breeding strategies to cultivate “super cotton”, synergistically improving multiple traits. These strategies must rise to meet urgent demands for a sustainable cotton industry.
A model to understand antecedents of nursing attitudes and perceptions influencing outcomes of patients with SUD
Authors: Vottero Beth , Schuler Monika , Kratovil Amanda 
Published: October 2022

AbstractIntroductionSubstance use disorder (SUD) is a persistent and long‐standing public health issue in the United States. While SUD is medically considered a chronic illness, it is also one that is viewed as self‐inflicted, thereby resulting in judgmental attitudes and stigmatization from care providers, specifically from nurses.DesignIn 2020, the authors completed an analytical cross‐sectional study that included open‐ended questions to examine nurses' knowledge and attitudes toward caring for patients with SUD across practice settings.MethodsA conceptual model was constructed by examining original study data and published literature on SUD, re‐analyzing themes, determining constructs and variables, then coming to a consensus on critical aspects of the model.ConclusionThe resulting conceptual model highlights antecedents of nursing behaviors that directly affect patient care outcomes, providing a roadmap to improving patient outcomes.Clinical relevanceUnderstanding antecedents that affect nurses' attitudes and perceptions of patients with SUD highlights changes that can influence patient outcomes.