bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Task-oriented mirrored upper-limb robotic training in subacute patients after stroke: a case control study
Authors: Wu Jingsong , Huang Zhenming , Deng Haiyin , He Youze , Huang Jia , Wu Jianhuang 
Published: December 2022

Abstract
Objective
People with stroke often have upper limb motor impairment, which has an impact on their activities of daily living and quality of life. Robotic-assisted training devices are used for upper limb rehabilitation, but their effectiveness in enhancing activities of daily living is not satisfactory yet. In this study, we combined task-oriented training and mirror training to an upper limb robot, created a task-oriented mirrored upper limb robot (Wisebot X5), and investigated the feasibility and safety of task-oriented mirror robot training for subacute stroke patients and observed its effects on upper limb motor function and activities of daily living.
Methods
Based on case-control principles, 32 patients with subacute stroke were assigned to receive task-oriented mirrored upper limb rehabilitation robot training for 30 minutes each time, 5 times per week for 4 weeks, or to receive the equivalent duration of conventional occupational therapy training. The primary outcome was the Fugl-Meyer Assessment of the Upper Extremity (FMA-UE), and secondary outcomes were the Modified Barthel Index (MBI), the Stroke Self-Efficacy Scale (SSEQ), the System Usability Scale (SUS), and the Chinese version of the Quebec User Evaluation With Assistive Technology(C-QUEST). Statistical analysis was performed with paired-samples t-test.
Results
Thirty-two patients participated and completed the study. After the 4-week intervention, for FMA-UE, the experimental group was better than the control group in terms of the change score from the baseline to post intervention (P༜0.05). For MBI and SSEQ, both the experimental and control groups showed significant increases after the intervention(P༜0.05). However, there was no statistical difference between the groups in terms of the change score from the baseline to post intervention(P༞0.05). The usability assessment reported a high level of satisfaction: mean SUS score is 74.84% (SD = 11.64), mean QUEST scale is 4.42 (SD = 0.31).
Conclusions
Task-oriented mirrored upper-limb robotic training is feasible and safe for patients with subacute stroke. It is beneficial in promoting the recovery of upper limb function and activities of daily living.
The Comparison of Adjuvant Mitomycin-C and Triamcinolone-Impregnated Nasal Packing for Endoscopic Dacryocystorhinostomy
Authors: Kim Sang Yoon , Chambers Christopher B , Ahn Jung Hyo 
Published: December 2022

Abstract
Purpose: This study compared the success rate and complications of adjuvant use of mitomycin C (MMC) and triamcinolone (TA)-impregnated biodegradable nasal packing in endoscopic dacryocystorhinostomy(DCR). We also evaluated the efficacy of the combined use of intraoperative MMC and TA-impregnated biodegradablenasal packing for endoscopic DCR.
Methods: We retrospectively reviewed the data of 198 eyes from 148 patients who underwent endoscopic DCR for acquired nasolacrimal duct obstruction. The patients were randomly divided into three groups. Group A included patients treated without intraoperative MMC but with TA-impregnated nasal packing. Group B included patients treated without TA but with intraoperative MMC and normal saline-impregnated nasal packing. Group C included patients treated with intraoperative MMC with TA-impregnated nasal packing.
Results: The results revealed no significant difference in the overall success rates between groups A (86.8%) and B (89.2%) (p = 0.377). However, group C (97.5%) showed a higher overall success rate than groups A and B, with statistically significant differences. The incidence rate of granulomas was significantly lower in group C (5%) than in groups A (20.8%) and B (15.2%) (p = 0.009). Other complications, like crust, synechiae, and revision surgery, did not differ significantly between the three groups.
Conclusions: The combined use of intraoperative MMC and TA-impregnated absorbable nasal packing was effective in preventing granulomas and enhancing the surgical success rate.Additionally, single use of MMC or TA nasal packing was not statistically different.
Whole-body vibration protects against early brain injury and neuroinflammation after experimental subarachnoid hemorrhage
Authors: Wang Yue , Ding Yingying , Zhang Wang , Sheng Yu , Chen Tao , Wang Yuhai 
Published: December 2022

Abstract
Whole body vibration (WBV), as a form of physical stimulation through mechanical vibration, has been proved to have neuroprotective effects on a variety of central nervous system (CNS) diseases. However, whether WBV plays a neuroprotective role in early brain injury (EBI) after subarachnoid hemorrhage (SAH) has not been well demonstrated. Herein, we focused on investigating the potential mechanism of the therapeutic effects of WBV on SAH-induced mice. The endovascular perforation was performed to induce SAH in C57BL/6J male mice. The mice were exposed to WBV twice a day at a frequency of 30 Hz for 20 days. The curative actions of WBV were assessed using the modified Garcia scale and the beam balance scoring system, along with measuring brain water content 24 h after SAH induction. TUNEL staining was performed to observe the apoptotic cells. Immunofluorescence staining was used to evaluate the expression of astrocytes and microglia in mice's cerebral cortex. Additionally, the ELISA assay was performed to detect inflammatory cytokines, such as IL-10, IL-18, and IL-1β. Western blot was conducted to explore the expression analysis of apoptosis-associated proteins (cleaved Caspase-3). Morris Water Maze (MWM) test and rotarod test were used to evaluate the long-term neurological function of mice. Nissl staining was used to evaluate the loss of neurons in the hippocampus of mice. Our study illustrated that WBV can reduce brain water content without significantly affecting the weight of mice. Also, the TUNEL-positive cell counts of the cerebral cortex of mice in the SAH+WBV group were significantly reduced compared with that in the SAH group. The protein level of cleaved Caspase-3 in the SAH+WBV group was also decreased than that in the SAH group. Immunofluorescence staining showed that WBV suppressed the high expression of GFAP and Iba-1 caused by SAH. MWM assay and rotarod test revealed that the long-term neurological dysfunction of mice following SAH was attenuated by WBV treatment compared with SAH-induced mice, which may be closely related to the low level of neuronal loss in the hippocampal regions. Our research demonstrated that WBV treatment can reduce EBI and neuroinflammation and improve the long-term neurological dysfunction of mice after SAH, which provides a new possibility for clinical treatment of SAH in the future.
Labor Market Flows Between the Two World Wars: Estimates for Interwar Italy, 1921-1940
Authors: Vojnovic Jovan , Magnini Gino 
Published: December 2022

Abstract

This paper estimates Italy’s labor market flows between 1921 and 1940 by exploiting evidence from three population censuses in 1921, 1931 and 1936. We compute historical series for the working-age population, inactive population, labor force and unemployed individuals. Further, we estimate seasonal agricultural workers to obtain a new unemployment series. We also estimate all labor market flows and series by gender in order to shed light on gender-based differences in labor outcomes in this period. Our estimates show that the Italian interwar period was characterized by falling labor participation and large increases in inactivity, primarily driven by women leaving the labor force. Our estimates are also reassessing the evolution of unemployment in the 1920s and 1930s. Unemployment rates were fairly high during the 1920s, with almost a third of unemployment made up of agricultural seasonal workers. Following the Great Depression, unemployment rates fell considerably due to the outflow of workers from the labor force. Finally, we estimate significant gender differences in labor market outcomes while both male and female participation and unemployment rates experience long-term negative trends.
Type 2 diabetes mellitus and oral health: A case-control study
Authors: Heidarpour Maryam , Mazroui Alireza , Azimipour Yasmin , kabirzadeh Arefeh , Manshaee Behrad , Rabbanipour Najmeh , Najimi Arash , Rezvanian Hassan , Shafie Davood , Faghihian Elham 
Published: December 2022

Abstract
Background: Type 2 diabetes mellitus (T2DM) is one of the main causes of disability and mortality in human societies. This study aims to investigate oral health changes in patients with T2DM.
Methods: A total of 70 T2DM cases and 140 non-diabetic controls were selected. A questionnaire was applied to gather data of the clinical history. An oral exam was performed to determine taste disorder, xerostomia, community periodontal index (CPI), premalignant lesions of the oral cavity, geographic tongue, candida-related lesions, and decayed, missing, and filled teeth (DMFT) index.
Results: The mean age of cases and control group was 52.29±6.62 years and 49.64±12.78 years Respectively. Participants with T2DM were more likely to had a higher DMFT index [odds ratio (OR), 1.24; 95% confidence interval (95% CI), 1.11-1.38, p<0.0001], coated tongue (OR, 3.25; 95%CI, 1.08-9.79, p=0.04), and xerostomia (OR, 5.64; 95%CI, 1.01-31.50, p=0.04) compared with non-diabetic participants. Also, among diabetic patients, the use of oral diabetes medication or insulin, as well as good (HbA1c ≤ 7%) or poor glycemic control, was not associated with oral health disorders.
Conclusion:This study revealed that physicians should pay more attention to the oral and dental issues of diabetic patients regardless of diabetes control status.
EFFECT OF BREASTFEEDING ON RISK OF DEVELOPING INFLAMMATORY BOWEL DISEASE
Authors: Tenlik İlyas , Öztürk Ömer , Çoşkun Orhan , Arı Derya , Bacaksız Ferhat , Yüksel Mahmut , Yeşil Bayram , Durak Muhammed Bahaddin 
Published: December 2022

Abstract
Purpose:This study aimed to investigate whether breastfeeding in early childhood affect the risk of devoloping IBD.
Methods:In order to investigate the effect of breast milk on the development of IBD and in order to reduce the effects of genetic and environmental factors, the patient data obtained from the survey were compared to the data of their non-IBD siblings as a control group.
Results: The data of 122 Crohn's disease patients were compared with the sibling group of 332 individuals, and the data of 182 ulcerative colitis patients with the sibling group of 508 individuals. Compared to the control group, it was determined that the proportion of those who never breastfed was statistically significantly higher in both the CD and UC groups (7.4% vs. 2.1% for CD, p=0.017 and 3.9% vs. 0.8% for UC, p=0.01), and the risk of disease increased significantly in those who wasn’t breastfed (OR= 3.70 [1.35-10.16] for CD, p=0.017 and OR= 5.07 for UC [1.47-17.53], p=0.010). It was determined that the protective effect increased against CD as the duration of breastfeeding increased, but that the protection increased with breastfeeding for up to 12 months for UC, and breastfeeding for more than 12 months did not provide additional protection. There was no relationship between breastfeeding and demographic and behavioral chracteristics of patients.
Conclusions: Not having been breastfed in infancy increases the risk of developing both UC and CD, and as the duration of breastfeeding increases, the protection against disease risk increases.
Synthesis of novel modified acrylamide copolymers for montmorillonite flocculants in water-based drilling fluid
Authors: Faridi Shirin , Mobinikhaledi Akbar , Moghanian Hassan , Shabanian Meisam 
Published: December 2022

Abstract
A study was conducted to treat the water-based drilling fluid through coagulation-flocculation. A series of acrylamide copolymers was prepared by in situ free radical polymerization in aqueous medium using ammonium persulfate as a radical initiator. The chemical structure of the prepared copolymers was confirmed by FT-IR and the polydispersity indices of the copolymers determined using gel permeation chromatography. Thermal gravimetric analysis showed that the copolymers have a very high temperature tolerance, i.e. they are stable up to 390°C. In this paper, acrylamide copolymers were used as coagulant with cationic, anionic groups or both of them simultaneously. Consequently, in order to clarify the relationship between inhibitive properties, sedimentation volume measurement, SEM, XRD and contact angle were adopted. Some factors including molecular weight and molecular chain affecting the interaction between copolymers and clay particles were analyzed. Anionic sample with the highest molecular weight can reduce the interlayer spacing of the hydrated clay to the minimum. Amphoteric sample exhibit the best performance as a coagulant in comparison with other copolymers.
WITHDRAWN: Oral Health Knowledge and Attitude among Nursing Students and Staff in Mahasamund City, India
Authors: Chandrakar Mayank , Prabhu Shruti 
Published: December 2022

Abstract
Introduction
The study was conducted to assess the oral health knowledge and attitude among nursing students and staff of Mahasamund city, India.
Materials and Methods
A total of 281 nursing students and staff from nursing colleges were included and requested to complete 25 questions close ended questionnaire.
Results
53% were of the view that tooth paste and brush is ideal material for brushing. Almost 66.4% reported that brushing should be done twice daily. Majority of them (65%) had sufficient knowledge for detection of Dental Caries. Most of them (70%) were interested in doing work in Public Health Dentistry.
Conclusion
Overall oral health knowledge and attitude of nursing students and staff was insufficient. Only half of the study participants were aware of various aspects of oral health. Nurses should have basic knowledge about oral health and disease.
Assessment of Preschool Preparedness Intervention Package on Adoption of Nutrition Friendly School Initiative in Rural Sindh, Pakistan: An Exploratory Sequential Mixed Method Design
Authors: Samnani Amir Ali Barket Ali , Karmaliani Rozina , Nuruddin Rozina , Petrucka Pammla , Soofi Sajid 
Published: December 2022

Abstract
Background
Early years of life are crucial for growth and development; any adverse events (such as nutrition deficiencies) during this period significantly influence children’s life-course developmental trajectories to maturity. In 1995, the World Health Organization launched its Global School Health Initiative with the aim of expanding the Health Promoting School (HPS) approach globally. Therefore the primary objective of this study is to assess the preschool preparedness intervention package in adoption of Nutrition Friendly School Initiative.
Methodology:
An exploratory sequential mixed method study design was carried out in three campuses of Aga Khan School (Mirpur Sakro, Junior Campus Vur, community-based school Sujawal) in the Sindh province of Pakistan. Study participants (children & parents) were selected using purposive sampling. Data collection includes in-depth interviews with the school community, pre & post assessment of knowledge of parents, baseline and end-line nutrition status of preschool children of age 24-59 months and beyond, and baseline & end line assessment of Preschool preparedness using checklist
Results/outcomes:
The qualitative findings has informed additional measures (setting up nutrition theme corner, including parenting package in manual, aligning school nutrition policy with school handbook, launch of special campaign for engagement and awareness purpose with parents) that were adapted within the intervention package. Preschool preparedness also improved from 10 points to 22 points out of 26 indicators (with some indicators labeled at not applicable). The knowledge of parents on nutrition and health promoting manual has been enhanced with mean improvement of 7.17 points (out of 25 points). Also the mean increase in MUAC, height and weight of preschool children are 0.27cm, 0.6cm and 0.26kg respectively.
Discussion and conclusion:
This initiative has improved preschools preparedness in creating an enabling environment in addressing health and nutritional problems within and beyond the classroom. Program implementers should not ignore this nexus of health, nutrition, and early child development by utilizing school platforms to improve the nutrition status and prevent all forms of malnutrition. Policy takeaway include initiating a school accreditation program to certify schools as Nutrition friendly and utilized the developed school nutrition policy developed to feed the development of National Nutrition Friendly school policy
Challenges and chances coexist: A visualized analysis and bibliometric study of research on bioresorbable vascular scaffolds from 2000 to 2022
Authors: Zhang Xiaohan , Guo Zezhen , Zhu Lihong , Liu Yao , Wang Huan , Jiang Yuchen , Du Bai , Hu Yuanhui 
Published: December 2022

Abstract
Background: Bioresorbable scaffold (BVS) provides a transient supporting force for blocked vessels and allows them to return to previous physiological characteristics. After the verification with twists and turns, it has been acknowledged as an emerging revolution of percutaneous coronary intervention (PCI), which expresses the current concept of intervention without placement. Through this bibliometric study, we organize the knowledge structure of bioresorbable scaffolds and attempt to predict future research hotspots in this field.
Methods: 12371 articles were retrieved from the WEB OF SCIENCE CORE COLLECTION (WoSCC) database from 2000-2022. Then, we utilize CiteSpace 6.1.R2 and VOSviewer 1.6.18 to analyze the data visually.
Results: Firstly, according to the spatial analysis, the quantity of annual publications shows an approximately increasing trend over the past two decades. The USA, the People’s Republic of China, and GERMANY published the most articles about bioresorbable scaffolds. Secondly, SERRUYS P ranked first for his most prolific work and the highest cited frequency in this domain. Thirdly, the hotspots in this field can be inferred from the keyword distribution; they were the fabrication technique based on tissue engineering, the factors to be optimized of bioresorbable scaffolds such as mechanical property, degradation, and implantation, and the common adverse effects of bioresorbable scaffolds such as thrombosis. Most importantly, in terms of burst detection, we could speculate that cutting-edge technology for manufacturing scaffolds represented by 3D printing constitutes the future hotspots in bioresorbable scaffold development.
Conclusion: We review the growing trend of bioresorbable scaffolds since their introduction and present the early prosperity, the subsequently questioned safety, and the resultantly advanced techniques in recent years. In brief, this review, the first visualized bibliometric analysis on BVS, enrolls extensive literature in this field and offers more guidance for future research from a panoramic view.
The polyol pathway and nuclear ketohexokinase A signaling drive hyperglycemia-induced metastasis of gastric cancer
Authors: Kang Ye-Lim , Kim Jiyoung , Kim Yi-Sook , Park Jong-Wan 
Published: December 2022

Abstract

Background:Diabetes is significantly associated with increased cancer risk, with several studies reporting hyperglycemia as a primary oncogenic stimulant. Glucose metabolism is linked to numerous metabolic pathways, making it difficult to specify the mechanisms underlying hyperglycemia-induced cancer progression. Here, we focused on the polyol pathway, which is dramatically activated under hyperglycemia and causes diabetic complications. We tested the possibility that polyol pathway-derived fructose facilitates hyperglycemia-induced gastric cancer metastasis.Methods: We performed bioinformatics analysis of gastric cancer datasets and immunohistochemical analyses of gastric cancer specimens, followed by transcriptomic and proteomic analyses to evaluate phenotypic changes in gastric cancer cells. We used two xenograft models to evaluate gastric cancer metastasis in patients with diabetes.Results: We observed a clinical association between the polyol pathway and gastric cancer progression. In gastric cancer cell lines, hyperglycemia enhanced cell migration and invasion, cytoskeletal rearrangement, and epithelial-mesenchymal transition (EMT). The hyperglycemia-induced acquisition of metastatic potential was mediated by increased fructose derived from the polyol pathway, which stimulated the nuclear ketohexokinase-A (KHK-A) signaling pathway, thereby inducing EMT by repressing theCDH1gene. In two different xenograft models of cancer metastasis, gastric cancers overexpressing AKR1B1, which catalyzes the rate-limiting step in the polyol pathway, were found to be highly metastatic in diabetic mice.Conclusions: Hyperglycemia induces fructose formation through the polyol pathway, which in turn stimulates the KHK-A signaling pathway, driving gastric cancer metastasis by inducing EMT. Thus, the polyol and KHK-A signaling pathways could be potential therapeutic targets for lowering the metastatic risk in gastric cancer patients with diabetes.
Towards electroencephalography-based consciousness assessment and cognitive function profiling in prolonged disorders of consciousness
Authors: Coyle Damien , Korik Attila , du Bois Naomi , Hodge Stephanie , Hudson Leah , Elahi Ainjila , Bigirimana Alain Desire , Dayan Natalie , McCann Alison , Yelden Kudret , McElligott Jacinta , Carroll Áine 
Published: December 2022

Abstract
Background: Electroencephalography (EEG) -based motor-imagery brain-computer interface (MI-BCI) systems can facilitate training of wilful modulation of sensorimotor oscillations in patients with prolonged disorders of consciousness, potentially enabling empirical assessment of awareness and movement independent responses and question answering.
Methods: A multistage, ten session, protocol was evaluated with twenty-four (N = 24) patients who have prolonged disorders of consciousness (PDoC) (unresponsive wakefulness syndrome (UWS) or minimally conscious state (MCS)) or locked-in syndrome (LIS). Phase one assessed capacity to modulate brain activity and thus detect awareness, phase two involved motor-imagery training with neurofeedback, and phase three assessed patients’ motor-imagery response to closed questions, categorised to assess biographical, numerical, logical, and situational awareness.
Results: Patients from all groups show significant capacity to modulate brain activity and respond to closed questions with motor imagery. A conservative approach to statistical testing was necessarily taken, due to a limited sample size and uneven groups. However, significant group differences were observed indicating patients with LIS outperform patients with PDoC. As patients diagnosed with UWS present evidence of command following in this protocol and thus could have MCS, significant differences between UWS and MCS across a range of tests were inconclusive although, in general, group performances are correlated with the level of awareness associated with clinical diagnosis.
Conclusions: We conclude that the proposed multistage protocol involving progression from motor imagery training with neurofeedback to closed question responses under the correct conditions may be effective for movement-independent consciousness profiling in prolonged disorders of consciousness.