bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study of connective tissue metabolites in biological fluids of patients with various types of glaucoma
Authors: Stepanova E. A. , Lebedev O. I. 
Published: August 2022

PURPOSE. To quantify the content of connective tissue metabolites reflecting the exchange of its main components in biological fluids in low tension glaucoma (LTG) and primary open-angle glaucoma (POAG), and to conduct a comparative analysis of the obtained data. METHODS. The studies were conducted in 33 patients with low tension glaucoma aged 51 to 80 years old (mean age 69 ± 10.4 years), 20 patients with POAG aged 53 to 80 years old (mean age 67 ± 10.1 years) and 15 clinically healthy volunteers aged 52 to 78 years old (mean age 68 ± 9.2 years). The protein components of the fibrous part of the connective tissue were analyzed for daily excretion of oxyproline in urine by the method involving para-Dimethylamin-obenzaldehyde modified by P.N. Sharaev. Serum glycosaminoglycans (GAG) were studied by analyzing carbohydrate components of connective tissue. The concentration of GAG in the blood serum was determined by the colorimetric method, using Dische's carbazole reaction. RESULTS. The amount of GAG in the blood serum of LTG patients was 3.26 ± 1.57 mmol/L, while in the control group consisting of clinically healthy volunteers — 2.92 ± 1.25 mmol/L. The differences were not statistically significant (p > 0.1). The amount of daily excretion of oxyproline in the urine of LTG patients was 17.17 ± 8.64 mmol/day, and in the group of clinically healthy individuals — 13.96 ± 5.61 mmol/day. The differences were statistically significant (p < 0.05). The amount of GAG in the blood serum of POAG patients was 3.97 ± 1.17 mmol/L. The differences in relation to LTG were statistically significant (p < 0.05). The amount of daily excretion of oxyproline in the urine of POAG patients was 32.71 ± 19.79 mmol/day. The differences were statistically significant in relation to LTG (p < 0.05). The amount of GAG and oxyproline in biological fluids tends to increase with the advancement of LTG and POAG. CONCLUSION. Destruction processes in the connective tissue do occur in LTG, but are less pronounced in comparison to POAG and more pronounced in comparison to healthy individuals. The indicator that most clearly reflects the activity of destructive processes in the connective tissue is the daily excretion of oxyproline in urine.
A clinical study of hydrodynamic parameters of the eye in primary open-angle glaucoma and low-tension glaucoma
Authors: Stepanova E. A. , Lebedev O. I. 
Published: August 2022

PURPOSE. To quantify the outflow of intraocular fluid along various pathways depending on the stage of the disease in typical primary open-angle glaucoma (POAG) and low-tension glaucoma (LTG) cases, and compare the obtained results. METHODS. This study involved 30 patients (57 eyes) with POAG at various stages, aged 58 to 80 years old (mean age 67 ± 8.0 years). The comparison group included 33 patients (62 eyes) with LTG at various stages aged 51 to 80 years old (mean age 69 ± 10.4 years). All subjects had no history of previous laser or surgical interventions on the studied eye. The controls were 15 clinically healthy individuals (30 eyes) of the same age group. On the first day, electronic tonography was performed using tonograph TNC- 100-S with a 4-minute recording of the curve. On the next day, tonography was per-formed with simultaneous blockade of the drainage outflow pathway using a perilimbal vacuum — compression ring according to the method by Prof. N.V. Kosykh. RESULTS. The overall ease of outflow coefficient (EOC) in POAG has a pronounced tendency to decrease with stage advancement. Its decrease in the II and III stages of the disease is 35 % and 30 %, respectively. The EOC for the uveoscleral pathway with POAG decreases in the II and III stages of the disease and amounts to 33.3 % and 25 %, respectively. The ratio of uveoscleral outflow in POAG increases by 3.3 % and 6.5 % in the II and III stages, respectively. With stage I and II LTG, this indicator is stable and remains at a fairly high level, and in the III stage it decreases by 33.3 % compared to stage II. The ratio of uveoscleral out-flow in LTG increases by 21 % in the II stage and by 11 % in the III stage of the disease. CONCLUSION. The rate of fluid outflow along the uveoscleral pathway is higher in LTG than in POAG. The ratio of uveoscleral outflow to overall outflow is greater in LTG in comparison with POAG. In this respect, it can be concluded that preservation of IOP within the limits of the average norm in LTG may be associated with a more pronounced function of the uveoscleral outflow pathway.
Comparative study of the efficacy and safety of 0.005 % Glaumax and 0.005 % Xalatan
Authors: Erichev V. P. , Zinina V. S. , Volzhanin A. V. 
Published: August 2022

PURPOSE. To compare hypotensive efficiency and safety of generic latanoprost 0.005 % (Glaumax, “KEVELT AS”, Estonia) and original latanoprost 0.005 % (Xalatan, “Pfizer Inc”, USA) in glaucoma patients. METHODS. The study included patients with newly diagnosed primary open-angle glaucoma or patients with primary open-angle glaucoma on carbonic anhydrase inhibitor monotherapy 4 days after cease of treatment (the “wash-out” period). Study patients were divided into 2 groups. Group 1 consisted of 25 patients (30 eyes) with initial and advanced stages of newly diagnosed POAG and initial corneal-compensated IOP (IOPcc) of 25.15 ± 1.48 mm Hg. This group of patients was prescribed instillations of 0.005 % Glaumax eye drops 1 time per day. Group 2 also included 25 patients (30 eyes) with initial stage of newly diagnosed POAG and initial corneal-compensated IOP (IOPcc) of 25.08 ± 1.42 mm Hg. Group 2 patients were prescribed instillations of 0.005 % Xalatan eye drops 1 time per day. IOPcc was measured initially after the washout period, then 1 and 2 months after the start of the new therapy. Additionally, all patients were assessed for tear film break up time (Norn’s test) at each follow-up point. RESULTS. After 1 month, IOPcc in groups 1 and 2 was 17.36 ± 1.39 and 18.09 ± 1.45 mm Hg, respectively; after 2 month, 17.87 ± 1.30 and 18.54 mm Hg, respectively. The Norn’s test results in groups 1 and 2 after 1 month were 8 (7; 9.75) and 8 (6; 9.75) seconds, after 2 months it was 8.5 (8; 9) and 8 (7; 10) seconds, respectively, which corresponded to the initial stage of the "dry eye" syndrome. No statistically significant intergroup differences were found in any of the cases. CONCLUSION. Xalatan 0.005 and Glaumax 0.005 have comparable efficacy and tolerability, and both help achieve persistent stabilization of IOP. The option for a single-instillation regimen is convenient for the patients.
Study of the comparison between the effect of E122 dietary dyes and silver nanoparticles extracted from the capparise spinosa plant at the level of fat in male rats
Authors: Gassad Sara Hameed , Fajer Ali Noory 
Published: August 2022

Carmoisine is a type of azo dye , which is widely used in ice cram, soft drinks, sauces and with sweets and others . This study is designed to determine the effect of carmoisine dye (E122) on certain male rat vestal criteria ,including measuring the effectiveness of lipid profile (cholesterol levels .Triglycerides and high-density HDL fatty profile and low –density LDL ).The current study showed that there was an increase in the level of fat (Ch,TG,LDL) in the group of E122 injecting animals but it was observed that there was amoral reduction in the HDL level compared to the group of controlling animals and AgNPS animals
Study the effect some of antioxidant in polycystic ovary syndrome women
Authors: Abd Zahraa Sabah , Hamzah Sundus Kareem 
Published: August 2022

This study was conducted at the Women and Children’s Hospital in Al-Qadisiyah from 1/10/2021 to 2/1/2022, and 50 patients were followed up for women suffering from polycystic ovaries on the third day of the menstrual cycle, and compared to the control group, which included 50 normal cases, which were confirmed to be free. Of the chronic diseases such as heart disease, thyroid, diabetes and blood pressure, the concentration of antioxidants was measured for both infected and non-infected women, including SOD, UA and MDA. A significant increase in antioxidants and decrease GSH was observed in women with PCOS compared to the control group. The concentration of copper, zinc, Cu and Zn elements was also measured, as we showed a high concentration of copper and a decrease in zinc in women with polycystic ovary syndrome compared to the control group.
Analytical method development and validation for the simultaneous estimation of Metoprolol and Benidipine by RP-HPLC in bulk and tablet dosage forms
Authors: Mujawar Tabrej , Ahmad Sufiyan , Gadilohar Hitesh , Deshmukh Nitin , Gaikwad Asmita , Sable Vijay , Bhosale Avinash 
Published: August 2022

Objective: The day by day new combinations drugs are being introduced in market. Then the multiple therapeutic agents which acts at different sites are used in the management of various diseases and disorders are done. Thus it is necessary to develop methods for analysis with the help of number of analytical techniques which are available for the estimation of the drugs in combination. An accurate, precise and reproducible RP-HPLC method was developed for the simultaneous quantitative determination of METO and BENI in tablet dosage forms. Methods: Younglin (S. K.) gradient system UV detector and C18 column with 250 mm x 4.6 mm i. d. and 5μm particle size Acetonitrile: OPA water (45: 55v/v) pH 2.5 was used as the mobile phase for the method. The detection wavelength was 230 nm and flow rate was 1ml/min. Results: In the developed method, the retention time of Metoprolol and Benidipine were found to be 2.9833 min and 7.3833 min. The developed method was validated according to the ICH guidelines. Conclusion: The developed method was validated according to the ICH guidelines. In this methods linearity, precision, range, robustness was within the limits as specified by the ICH guidelines.
Natal and neonatal teeth a case series - from south India
Authors: Margaret A Priya , Kumar S Ramitha Enakshi , Ravanagomagan Ravanagomagan 
Published: August 2022

Teeth eruption into the oral cavity follows a chronology. Small variations depending on endocrine, genetic and environmental factors can alter the chronology of teeth eruption. The occurrence of teeth at birth is called natal teeth and when teeth arise within 30 days of birth it is called neonatal teeth. The occurrence of natal and neonatal teeth is an uncommon anomaly. It is associated with a lot of superstition in various ethnic group. If the natal and neonatal teeth do not interfere with feeding nor are they causing any ulceration they can be left in place. Some natal and neonatal teeth cause injury to the mother on feeding and can cause tongue ulceration in the neonate. In such cases the teeth can be removed. If the natal and neonatal teeth are extremely mobile such that reattachment in unlikely and there is a danger of aspiration of the tooth, then they can be removed. We describe in this report 4 neonates with natal and neonatal teeth.
PCR detection of Gene lip and plcN1 encoding lipase and lecithinase of Stenotrophomonas malltophilia isolated from different infection
Authors: Al_Mosawy Mohammed Shihab , AI_Muhanna Abbas Shaker 
Published: August 2022

Stenotrophomonas maltophilia is a low-virulence opportunistic pathogen that has been identified as an emerging hospital pathogen, Infections caused by S. maltophilia have increased over the years due to increased high-risk patients e.g. patients with immune suppression, hematological malignancies, ICU admission, It is an aerobic, gram- negative, bacilli, motile, non_capsulated and non_ferment glucose, has several virulence potentials for causing various infection. therefore this study conducted to characterization and molecular investigation of some extracellular virulence factor particularly lipase and lecithinase and detection of gene encoding this factors (lip and plcN1genes) in order to determinants the role of this bacteria in causing infection in Al- Najaf province. Therefore 485 clinical specimens were collected from different infection 315(64.9 %) of specimens were collected from male and 170(35.1%) from female, the specimens were cultured on suitable media and cultivated at 37 ℃, The results showed that 373(76.9%) gave bacterial growth while 112(23.1%) appeared no growth. after identification of bacterial isolate, 20 of isolate were identified S. maltophilia recovered from the different infections, from those 12 of isolates were recovered from male specimens, while 8 from female, PCR were used to determinant the predominant of lipase and lecithinase genes among S. maltophilia isolates,,,
Documenting Nigeria’s Hip Hop Music Evolution in Nollywood: an Examination of Tunde Kelani’s Campus Queen
Authors: Adedeji Wale 
Published: August 2022

It has been established that the Nigerian music industry has grown tremendously in recent times through the popularity and dynamism of the Hip hop genre, which has positioned itself as the mainstream music presently. Likewise the Nigerian film industry now referred to as Nollywood is credited as the fastest growing film industry and rated the third largest film industry in the world after Hollywood and India’s Bollywood and currently accounts for an estimated N 853.9 billion ($7.2 billion) or 1.42 percent of Nigeria's GDP. This paper establishes the interface between popular music culture (hip hop) and Nollywood through the notion of documentation with a highlight of how Hip hop music is being documented in Nollywood formative years either consciously or un-consciously. The paper adopts a qualitative research method with an in-depth analysis of music in the movie-Campus Queen.
THE ROLE OF THE EDUCATOR IN IMPROVING THE LEARNING PROCESS THROUGH THE PAULO FREIRE PROBLEM METHOD
Authors: R. Deti Rostika Aulia Nurjannah, Latifah Meynawati, 
Published: August 2022

This research aims to look at how to improve the role of educators in the learning process, especially through Paulo Freire's problematic education concept. As it can achieve the expected goals in the learning process, the role of educators is very important. This study employs a qualitative method with a descriptive design in which it provides a careful description of certain individuals or groups about the conditions and symptoms that occur. In this study, the author uses data techniques based on analyzing the thoughts, biographies, and especially in the concept of problems with the perspective of Paulo Freire descriptively. Traditional methods are still widely used by educators today who are lacking in the learning process, which according to Paulo Freire is called the concept of bank style or the existence of oppression of students, with educators as the dominating party, and arguably are the same direction as students. In this case, the author uses the concept of Education Against Problems to streamline the learning process that can be used to achieve a goal. The educator along with the learner is placed as an educational subject who knows himself, in order to achieve more knowledge in the form of purity and knowledge as an object. Therefore both parties are in the same position as learners, and interact in providing knowledge information in a straight line.
Hearing profile in patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus
Authors: Yousef Mahmoud Gamal Mohamed , Ghazaly Abdel-Hameed Abdel-Hareth , Awwad Hassan Mohamad , Mahmoud Ahmed Mohamed Ahmed 
Published: August 2022

Introduction and aim: Rheumatoid arthritis (RA) and Systemic Lupus Erythematous (SLE) are chronic, inflammatory diseases with intra and extra articular manifestations. They affect 1% of the population. The auditory system can be affected in the course of these diseases. However, the pathogenesis of hearing impairment in these diseases is not clearly understood. The current work aimed to determine frequency and type of hearing impairment (HI) in patients with RA and SLE and possible correlation with different disease parameters.
Methodology: Fifty RA and Fifty SLE patients, and 50 healthy, age and sex matched controls, were included. Their age ranged from 35 to 50 years. They were selected from the outpatient clinic of Al-Azhar university hospital (Damietta). HI was evaluated by pure tone audiometry and tympanometry including acoustic reflex threshold test and auditory brain stem response (ABR). Complete medical history and general & local examination were done along with full laboratory and immunological investigation.
Results: Hearing loss was found in 41(82%) in RA patients and in 19 (38%) in control group. Hearing loss in SLE patients was found in 27(54%) and 15(30%) in control group. In AR patients, the level of hearing loss varied from mild to moderate in 28(56%) and 13(26%) respectively, and in control group was 17(34%) and 2(4%) respectively. In SLE group, level of hearing loss varied from mild to moderate in 19(38%) and 8(16%) respectively, and in control group was 13(26%) and 2(4%).
Conclusion: There was a high frequency of sensorineural hearing loss in both RA (82%) and SLE (54%) patients compared to normal controls. Careful surveillance of hearing profile in early stages of both diseases is important and follow up testing of hearing status should be part of patient care.
Platelets and White Blood Corpuscles' Indices for the Prediction of Premature Rupture of Membranes
Authors: El-Naggar Dalia Ahmed , Elhelw Ehab Mohammed , Emam Abdelrahman Ali Hassan , Aboelmaaty Hamada 
Published: August 2022

Introduction and aim: Premature rupture of membranes (PROM) is a common condition that is usually associated with adverse maternal and fetal outcome. Early identification is crucial to institute proper management strategies. The current study aimed to evaluate the role of platelets and white blood cells (lymphocytes and neutrophil) in prediction of PROM
Methodology: The study included 100 pregnant females. All were subjects to full clinical evaluation. Then vaginal examinations were completed to inspect for the active flowing of amniotic fluid from the cervix. A transabdominal ultrasound was done to confirm gestational age and estimate amount of amniotic fluid and turbidity. Complete blood cell count and differential count of leucocytes was performed and specific ratios were calculated.
Results: We have two groups, the study (PPROM) and females without PROM (control group). White blood cell, platelets, and neutrophils were significantly increased, while lymphocytes and monocytes were significantly decreased in the study than the control group. Mean platelet volume (MPV) and amniotic fluid index (AFI) were significantly reduced in the study than the control group (8.37±0.49, 4.39±0.65 vs. 10.04±0.68 and 11.20±1.18 respectively). However, platelet lymphocyte and neutrophil lymphocyte ratio were significantly increased in the study than control group (139.88±9.34, 5.58±0.70 vs. 127.50±4.70 and 4.06±0.54 respectively). The predictors of PPROM were AFI (η=0.619) followed by mean platelet volume (η=0.254) and finally NLR (η=0.075).
Conclusion: Blood cell count indices are useful indicators in screening for possible development of PPROM. In addition, MPV and NLR as useful predictors of PPROM. The availability, simplicity and low cost of such tests increased its value as a potential indicators for development of PPROM.
Operative Fixation of Displaced Midclavicular Fractures in Adult by Titanium Elastic Nailing System
Authors: Ahmed Atef Abd-Elmonem Abozid  , Fathy Hamza Salama  , Mohamed Abdallah Hassan  
Published: August 2022

Introduction and aim: Clavicular fractures are very common, and it usually treated conservatively. However, recent shift to surgical intervention had been observed. The guidelines seem to be in its road to change. The aim of this work is to asses clinical and radiological results of surgical fixation of midshaft clavicle fractures by Titanium Elastic Nailing System.
Methodology: Fifteen patients with mid-shaft (middle third) displaced fractures of the clavicle were included. All were assessed in systematic manner (history, examination and investigations). Then, eligible patients provided an informed consent and underwent surgical treatment according to study protocol. All were followed up for 6 months and their outcome was ranged according to Constant and Murley Score.
Results: Ten patients (66.7%) had excellent, 3 patients (20%) had good, one patient (6.7%) had fair, and one patient (6.7%) had poor outcome. Pain was absent or mild in the majority of patients (93.3%). 86.7% of patients return to full work, and all had unaffected sleep. Union was achieved in 14 patients (93.3%). One patient had an infection, two had medial end skin irritation and one had hypertrophic non-union. Younger age and absence of any associated medical disease were associated with excellent outcome.
Conclusion: Titanium Elastic Nailing could be considered as a reasonable alternative approach to the management of displaced mid-shaft clavicular fractures, as it is associated with excellent outcome, low pain, and early return to normal daily activities.
The Role of Breast Arterial Calcification on Mammogram as a Predictor for Risk of Coronary Artery Disease in Women
Authors: Abdallah Mohamed Sobhy  , Ahmed Mohamed Fekry Eldeek  , Elsayed Mohamed Abd El-Hamid  
Published: August 2022

Introduction and Aim: Cardiovascular disease is a leading cause of death worldwide. Thus, the detection of mammographic arterial calcifications can be an early, noninvasive instrument for predicting the possible development of coronary heart disease in women. The current work aimed to assess the significance of Breast arterial calcification (BAC) detected by digital mammogram and its relation to coronary artery calcium score and degree of coronary artery stenosis if present.
Patients and methods: The study included 100 female patients submitted to digital mammography for breast cancer screening programs and showed BAC then coronary artery calcification (CAC) score and multidetector coronary computed tomography angiography (MDCCTA) had done to determine the severity of coronary artery stenosis.
Results: The age was ranged between 40 and 80 years; the mean was 56.7+9.42 years. The prevalence of positive BAC and CAD were 50% and 10%, respectively. Hypertension, diabetes mellitus (DM), hyperlipidemia, and Family history of cardiovascular disease was higher in the BAC (+) than in BAC (-) group. The presence of BAC appears to strongly and proportionately correlate with CAC Score and Coronary artery stenosis as determined by coronary CTA (r =0.809, and r = 0.811, respectively).
Conclusion: BAC can indicate a risk of CAD development. Besides, there was a significant correlation between BAC and some cardiac risk factors ( e.g., age, family history of CAD, and DM).