bluuebunny/crossref_metadata_2025_split huggingface dataset:
No time to die? Intrinsic apoptosis signaling in hematopoietic stem and progenitor cells and therapeutic implications
Authors: Hagenbourger Florian , Bohler Sheila , Erlacher Miriam 
Published: July 2022

Purpose of review
Dysregulated apoptosis contributes to the pathogenesis of many hematologic malignancies. BH3-mimetics, antagonists of antiapoptotic BCL-2 proteins, represent novel, and promising cancer drugs. While the acute myelosuppressive effects of Venetoclax, the first Food and Drug Administration approved BCL-2 inhibitor, are fairly well described, little is known about side effects of novel BH3-mimetics and effects of chronic Venetoclax treatment.

Recent findings
Highly relevant publications focused on the effects of acute and chronic Venetoclax therapy, with focus on cell-type specific adaptive mechanisms, the emergence of clonal hematopoiesis, and the selection of BAX-mutated hematopoietic cells in patients treated with Venetoclax for a long period. Important advances were made in understanding primary and secondary Venetoclax resistance and prediction of Venetoclax response. Combination therapies of BH3-mimetics targeting different BCL-2 proteins are highly anticipated. However, human stem and progenitors require both MCL-1 and BCL-XL for survival, and serious myelosuppressive effects of combined MCL-1/BCL-XL inhibition can be expected.

Summary
Long-term studies are indispensable to profile the chronic side effects of Venetoclax and novel BH3-mimetics and better balance their risk vs. benefit in cancer therapy. Combination therapies will be powerful, but potentially limited by severe myelosuppression. For precision medicine, a better knowledge of BCL-2 proteins in the healthy and diseased hematopoietic system is required.
The new metabolic needs of hematopoietic stem cells
Authors: Bartram James , Filippi Marie-Dominique 
Published: July 2022

Purpose of review
Hematopoietic stem cells (HSCs) are endowed with high regenerative potential to supply mature blood cells throughout life, under steady state or stress conditions. HSCs are thought to rely on glycolysis when in a quiescent state and to switch to oxidative phosphorylation to meet their metabolic needs during activation. Recently, a series of important studies reveals a higher degree of complexity that goes well beyond the dichotomy between glycolysis and oxidative phosphorylation. The purpose of this review is to summarize the recent findings highlighting the multifaceted metabolic requirements of HSC homeostasis.

Recent findings
Emerging evidence points to the importance of lysosomal catabolic activity and noncanonical retinoic acid pathway in maintaining HSC quiescence and stemness. HSC activation into cycle seems to be accompanied by a switch to glycolysis-mitochondrial coupling and to anabolic pathways, including Myc, aspartate-mediated purine synthesis.

Summary
Knowledge of metabolism of HSCs has dramatically increased in the past 2 years and reveals unexpected needs of HSCs during both their quiescent and activated state. Understanding how HSCs use metabolism for their functions will offer new opportunity for HSC-based therapies.
Connecting tremors – a circuits perspective
Authors: Buijink Arthur W.G. , van Rootselaar Anne-Fleur , Helmich Rick C. 
Published: July 2022

Purpose of review
Tremor is one of the most prevalent movement disorders in clinical practice. Here, we review new insights in the pathophysiology of tremor. We focus on the three most common tremor disorders: essential tremor (ET), dystonic tremor syndrome (DTS), and Parkinson's disease (PD) tremor.

Recent findings
Converging evidence suggests that ET, DTS, and PD tremor are all associated with (partly) overlapping cerebral networks involving the basal ganglia and cerebello-thalamo-cortical circuit. Recent studies have assessed the role of these networks in tremor by measuring tremor-related activity and connectivity with electrophysiology and neuroimaging, and by perturbing network components using invasive and noninvasive brain stimulation. The cerebellum plays a more dominant and causal role in action tremors than in rest tremor, as exemplified by recent findings in ET, DTS, and re-emergent tremor in PD. Furthermore, the role of the cerebellum in DTS is related to clinical differences between patients, for example, whether or not the tremor occurs in a dystonic limb, and whether the tremor is jerky or sinusoidal.

Summary
Insight into the pathophysiological mechanisms of tremor may provide a more direct window into mechanism-based treatment options than either the etiology or the clinical phenotype of a tremor syndrome.
Deep brain stimulation in dystonia: factors contributing to variability in outcome in short and long term follow-up
Authors: Tisch Stephen 
Published: July 2022

Purpose of review
Deep brain stimulation (DBS) is currently the most effective treatment for medically refractory dystonia with globus pallidus internus (GPi) usually the preferred target. Despite the overall success of DBS in dystonia, there remains variability in treatment outcome in both short and long-term follow-up, due to various factors. Factors contributing to variability in outcome comprise ’Dystonia Related’ including dystonia classification, semiology, duration, body distribution, orthopaedic deformity, aetiology and genetic cause. The majority of these factors are identifiable from clinical assessment, brain MRI and genetic testing, and therefore merit careful preoperative consideration. ’DBS related’ factors include brain target, accuracy of lead placement, stimulation parameters, time allowed for response, neurostimulation technology employed and DBS induced side-effects. In this review, factors contributing to variability in short and long-term dystonia DBS outcome are reviewed and discussed.

Recent findings
The recognition of differential DBS benefit in monogenic dystonia, increasing experience with subthalamic nucleus (STN) DBS and in DBS for Meige syndrome, elucidation of DBS side effects and novel neurophysiological and imaging techniques to assist in predicting clinical outcome.

Summary
Improved understanding of factors contributing to variability of DBS outcome in dystonia may assist in patient selection and predicting surgical outcomes.
The effect of mobile device usage on creating text reviews
Authors: Park Keeyeon , Kim Hye-Jin , Kim Jong Min 
Published: July 2022

PurposeThe purpose of this study is to examine how the usage of mobile devices influences text-posting behavior in the online review-generation process. This study attempts to improve the understanding of the negative impacts of mobile channels on the quality of online reviews.Design/methodology/approachThe authors develop a series of hypotheses to investigate the text-posting behaviors with mobile device usage. To examine the authors' hypotheses, the authors collect online reviews posted in London hotels on Booking.com. The authors first use a logistic regression model to examine the relationship between the usage of mobile devices and text-posting behavior. Then, the authors explored the characteristics of textual content in mobile reviews compared to reviews written via traditional devices.FindingsThe authors' finding shows that the use of mobile devices negatively influences text-posting behavior. Compared to traditional devices, consumers are less likely to post texts in their reviews with mobile devices. Although consumers decide to post text comments in consumers' reviews, the quality of textual content is relatively low – short in length, with limited analytical thinking and less authenticity.Originality/valueTo the best of the authors' knowledge, no study has attempted to explore text generation in review-posting behaviors in the context of mobile channels. Also, the authors' findings show the negative effects of using mobile channels on the value of generated information, which is counterintuitive to previous research.
The impact of executive isolation of CEO on CXOs attrition: a case study of a not-for-profit organization
Authors: Kappal Rishi , Mishra Dharmesh K. 
Published: July 2022

Purpose
This paper aims to explore the interlinkage and association of executive isolation at the workplace faced by Chief Executive Officer (CEO) of a not-for-profit organizations (NPOs) and its impact on the attrition at the C-Suite Professionals (CXO), Direct reports of CEO levels.

Design/methodology/approach
Executive isolation at top management with reference to the CEO level has emerged as a major challenge that is faced by NPOs with the effect being multiplied by the pandemic and remote working. This paper intends to examine the relevance of the impact of executive isolation experienced by top management leading to increase in the attrition at the CXO levels in NPOs due to their increasing dissatisfaction. To make a thorough study, a detailed literature review has been done followed by qualitative research methods of individual interviews, group interviews and surveys to ascertain the implications of CXO-level executive isolation on the CXOs attrition in NPOs.

Findings
The executive isolation experienced by CEOs makes them develop certain preconceived set of beliefs. By being isolated from the direct report CXOs and action on the ground and working from a remote location, they tend to inculcate their own decisions into the direct reports, thereby depriving them of authority and autonomy. This starts leading to the high level of CXO attrition.

Research limitations/implications
This paper has tried to study the linkage of the executive isolation at top management with the levels of CXO dissatisfaction leading to attrition at NPOs. This topic appears to be much-needed to be understood, especially when the new normal of work is being redefined.

Practical implications
The paper enumerates that the NPOs can attempt to deal with the challenges of engaging CXOs through virtual working; however, the mindfulness can be impacted by the experiences of executive isolation at management levels. This, in turn, can lead to lower morale, compromised performance resulting in CXO-level dissatisfaction and attritions.

Originality/value
With the limited awareness about executive isolation and its multiplier effect due to the pandemic, NPOs, like other enterprises, had to resort to virtual working. However, executive isolation at management levels apparently leads to reduction in the CXO-level engagement with the teams under them and with the CEO to which they report. This aspect can lead to the NPOs not being able to achieve their impact objectives during the outward turbulence and inward challenges of CXO-level attritions because of the CXO-level dissatisfaction.
How TikTok leads users to flow experience: investigating the effects of technology affordances with user experience level and video length as moderators
Authors: Zhao Hongying , Wagner Christian 
Published: July 2022

PurposeAlthough the short-video-based application TikTok and its AI-enhanced technology have achieved enormous success and reshaped the user experience, few studies have focused on the user experience in the TikTok context. This study adopts a technology affordance theory lens to identify the main mechanisms contributing to the user experience in the short-video platform context while including user experience level and video length as moderating effects.Design/methodology/approachThis study collected 401 valid questionnaires from TikTok users and used the structural equation modeling approach to examine the proposed research model.FindingsThree technology affordances (perceived effortlessness, perceived recommendation accuracy, and perceived recommendation serendipity) contribute to TikTok users' optimal flow experience. Multi-group analysis results further indicate that individuals react differently to the same stimuli as their experience level increases. Finally, video length critically influences the impact of technology affordances on users' cognitive responses.Originality/valueAs a burgeoning industry, the mechanisms enabling short-video platforms to engage users remain unclear to practitioners and researchers. Thus, this study's technology affordance lens provides necessary insights into how TikTok's innovative and advanced technologies contribute to user flow experience from a context-dependent perspective. Furthermore, given that most existing studies have neglected possible variations in user preferences when investigating the effects of technology, this study enriches the existing literature by employing user experience level and video length as moderators.
Explaining individual job performance in work from home (WFH) arrangements
Authors: Danilova Kjersti Berg , Ulfsten Andreas , Eikebrokk Tom Roar , Iden Jon , Johannessen Trond Vegard , Johanson Daniel 
Published: July 2022

PurposeThis study investigates which factors are conducive to individual job performance in large-scale work from home (WFH) arrangements that rely on the current generation of technology, such as information and communications platforms.Design/methodology/approachThe researchers proposed a research model based on research on WFH arrangements. The model was tested based on a survey of 1,183 respondents who engaged in large-scale WFH arrangements during an extensive national COVID-19 lockdown.FindingsThe proposed research model explains 41% of the variance in individual job performance in WFH arrangements. The findings show that the strongest positive predictors for job performance are home office quality and the reach and communication quality of information and communications platforms. A sense of professional isolation was found to have a negative impact.Originality/valueThis study is based on a unique situation of large-scale mandatory WFH arrangements that are comparable to a natural experiment, and it is one of the first studies to conduct an extensive exploration of WFH that relies on the current generation of digital technology.
Political skill and cross-cultural adjustment among self-initiated expatriates: the role of host employer's psychological contract fulfillment
Authors: Koveshnikov Alexei , Wechtler Heidi , Moeller Miriam , Dejoux Cecile 
Published: July 2022

PurposeUsing social influence theory, this study examines the relationship between self-initiated expatriates' (SIE) political skill, as a measure of their social effectiveness, and cross-cultural adjustment (CCA). It also tests whether the host employer's psychological contract (PC) fulfillment mediates this relationship.Design/methodology/approachPartial least square structural equation modeling (covariance-based SEM) technique is employed to analyze a sample of 209 SIEs.FindingsThe study finds SIEs' political skill positively and significantly associated with SIEs' work-related adjustment. The relationship with interactional adjustment is only marginally significant. It also finds that SIEs' PC fulfillment mediates the relationship between SIEs' political skill and work-related adjustment. The mediation is marginally significant for the relationship between SIEs' political skill and general living adjustment.Originality/valueThe study adds to the literature on expatriates' skills and CCA by theorizing and testing the hitherto unexplored role of SIEs' political skill in their work and non-work CCA. It also theorizes and examines the host employer's PC fulfillment as a mediating mechanism, through which SIEs' political skill facilitates their CCA. Finally, it advances the literature on political skill by testing the construct's application in the cross-cultural and non-work domain.
Effects of inventive capabilities on new product development performance: the knowledge combination view
Authors: Xu Luyun , Yin Xin , Gong Hong , Zeng Deming 
Published: July 2022

PurposeA firm's inventions provide technical information for product planning and technical support for new product development (NPD). In the knowledge-based theory, inventing is regarded as a process of knowledge combination. This paper aims to classify the firm's inventive capabilities based on the combinatorial view and investigate the effects of inventive capabilities on NPD performance.Design/methodology/approachFour types of inventive capabilities are identified concerned with the knowledge used to combine in the inventive activities. By utilizing a dataset of 572 firms from China's automotive manufacturing industry, the roles of different inventive activities in the generation of new inventions are compared. Then the effects of different inventive capabilities on NPD performance are empirically examined by using negative binomial regression analysis.FindingsThe time series for the number of patented inventions derived from different types of combinations generally exhibits a steady upward trend, and the number of patents derived from recombination is much higher. The empirical results demonstrate that the inventive capabilities associated with reused recombination and creative recombination exhibit positive effects on NPD performance, and the inventive capabilities associated with novel combination and original combination exhibit non-linear effects on NPD performance.Originality/valueThe findings contribute to NPD literature by investigating the effects of different inventive capabilities on NPD performance. This study also provides guidelines for manufacturing managers to improve NPD performance by building appropriate inventive capabilities.
Online customer reviews: insights from the coffee shops industry and the moderating effect of business types
Authors: Tao Shuting , Kim Hak-Seon 
Published: July 2022

Purpose
This study aims to explore the hidden connectivity among words by semantic network analysis, further identify salient factors accounting for customer satisfaction of coffee shops through analysis of online reviews and, finally, examine the moderating effect of business types of coffee shops on customer satisfaction.

Design/methodology/approach
Two typical major procedures of big data analytics in the hospitality industry were adopted in this research: one is data collection and the other is data analysis. In terms of data analysis, frequency analysis with text mining, semantic network analysis, CONCOR analysis for clustering and quantitative analysis with dummy variables were performed to dig new insights from online customer reviews both qualitatively and quantitatively.

Findings
Different factors were extracted from online customer reviews contributing to customer satisfaction or dissatisfaction, and among these factors, the brand-new factor “Sales event” was examined to be significantly associated with customer satisfaction. In addition, the moderating effect of business types on the relationship between “Value for money” and customer satisfaction was verified, indicating differences between customers from different types of coffee shops.

Research limitations/implications
The present study broadened the research directions of coffee shops by adopting online customer reviews through relative analytics. New dimensions such as “Sales event” and detailed categorization of “Coffee quality”, “Interior” and “Physical environment” were revealed, indicating that even new cognition could be generated with new data source and analytical methods. The industry professionals could develop their decision-making based on information from online reviews.

Originality/value
The present study used online reviews to understand coffee shop costumer experience and satisfaction through a set of analytical methods. The textual reviews and numeric reviews were concerned simultaneously to unearth qualitative perception and quantitative data information for customers of coffee shops.
X‐ray‐based machine vision technique for detection of internal defects of sterculia seeds
Authors: Xue Qilong , Miao Peiqi , Miao Kunhong , Yu Yang , Li Zheng 
Published: July 2022

AbstractAn online machine learning system based on X‐ray nondestructive quality evaluation technique was developed to detect internal defects of boat‐fruited sterculia seed. The X‐ray images of boat‐fruited sterculia seed were first acquired by the detection system. Then, a boat‐fruited sterculia seed net (BSSNet) was trained to identify the defective boat‐fruited sterculia seeds based on the X‐ray images. The BSSNet was evaluated with the accuracy, precision, specificity, and sensitivity as 94.64%, 93.51%, 92.37%, and 96.64%, respectively. Further, three classical CNN models including VGG16, Resnet, and Inception were trained on the same dataset with accuracy of 95.71%, 94.29%, and 94.64%, respectively. Compared with the classical CNN models, the BSSNet achieved similar or higher accuracy in X‐ray images classification. Finally, an independent dataset containing 200 X‐ray images was used to validate the performance of the BSSNet and obtained an accuracy of 96.5%. The results presented above demonstrated that this classification method has a great potential for industrial applications.Practical ApplicationAn X‐ray online detection system integrated with a machine vision model was used to evaluate the quality of boat‐fruited sterculia seed. A low‐power x‐ray detection system can detect internal defects of the object and ensure safety in the production process. The developed machine vision can sort the boat‐fruited sterculia seed with an accuracy of 96.5%. The proposed nondestructive detection system showed a good potential to be used in industrial applications.
Comparative evaluation of encapsulation using β‐cyclodextrin versus freeze‐drying for better retention and stabilizing of black Périgord truffle (Tuber melanosporum) aroma
Authors: Phong Win Nee , Al‐Salami Hani , Gibberd Mark R. , Dykes Gary A. , Payne Alan D. , Coorey Ranil 
Published: July 2022

AbstractThis study aimed to develop a novel technique to retain and stabilize compounds contributing to truffle aroma by encapsulation using β‐cyclodextrin. Two experiments were conducted. In the first experiment, the key volatile profile and microbial population of products resulting from three different encapsulation methods, namely direct mixing method (M1), direct mixing followed by ethanol addition method (M2), and paste method (M3), were compared with untreated truffles (positive control) over a 90‐day period. The M2‐derived product was the least optimal for retaining key volatile compounds despite showing the lowest microbial population. There was no significant difference in the volatile profile of products derived from M1 and M3 on day 0. However, it was observed that the M3‐derived product could retain its volatile profile better than the M1‐derived product by day 90. M3 was compared with freeze‐drying in the second experiment. Freeze‐dried truffles showed an overall higher relative percentage of volatiles than the M3‐derived product on day 0. However, by day 90, some volatile changes occurred in the freeze‐dried truffles but not in the M3‐derived product. The findings indicate that while freeze‐drying could adequately conserve truffle volatiles, the encapsulation of volatile compounds in β‐cyclodextrin could improve the volatile stability of truffle products and allow for longer storage times. Microbes were found in all encapsulated truffle products and freeze‐dried truffles on days 0 and 90, suggesting the need to explore the possibility of incorporating a decontamination step in the process prior to either encapsulation or freeze‐drying.Practical ApplicationA technique to capture and stabilize compounds responsible for truffle aroma by encapsulation using β‐cyclodextrin was developed and compared with freeze‐drying in this study. The overall finding suggests that while freeze‐drying of truffle could sufficiently preserve volatiles, encapsulating truffle volatiles with β‐cyclodextrin may improve its stability, extending its shelf life, which can be applied in the development of a natural truffle ingredient that can be applied in food product development.