bluuebunny/crossref_metadata_2025_split huggingface dataset:
Store-and-forward teleneurology results in a large Brazilian city
Authors: Scavasine Valéria Cristina , Ribas Michelle Zonkowski , Augustin Gabriella , Zetola Viviane de Hiroki Flumignan , Ducci Renata Dal-Prá , Lange Marcos Christiano 
Published: October 2022

Abstract
Background Neurology is a high-demand specialty with long waiting lines. Some pathologies require rapid decision-making. Through technology, telemedicine can allow neurological patients to have faster access to specialized assessment. In store-and-forward telemedicine, the specialist physician evaluates data collected by a general practitioner and optimizes screening.
Objective The aim of the present study is to evaluate the effectiveness of asynchronous telemedicine, used to refer patients from primary care to neurology, in the city of Curitiba, in southern Brazil.
Methods A retrospective analysis of all patients referred from primary care to neurology between September 2019 and February 2020. After a request is made by a general medical doctor for a specialist's opinion, 5 neurologists with complete access to patients' records are tasked with the decision-making. The main variables analyzed were clinical reasons for telemedicine request, neurologist decision, final diagnosis, indication for diagnostic procedures, and subsequent follow-up.
Results Between September 2019 and February 2020, 1,035 asynchronous telemedicine consultations were performed. Headache (30.43%), epilepsy (19.03%), and dementia (15.85%) accounted for almost two-thirds of the primary care requests; one-third of the cases (33.62%) required a complementary diagnostic procedure. More than 70% of the cases did not require face-to-face assessment by a neurologist.
Conclusions In this study, store-and-forward teleneurology successfully reduced the need for in-visit consultation in 70% of cases. Further studies should identify the best opportunities for teleneurology in the city of Curitiba to facilitate better integrated care between primary care providers and neurologists.
Paul Bouts and the Short Life of Psychognomy in Brazil
Authors: André Charles 
Published: October 2022

AbstractPaul Bouts (1900–1999) was a Belgian pedagogue, a Roman Catholic priest, and the founder of Psychognomy, which is a personality diagnostic system combining phrenology and several related practices – typology, craniofacial measurements, physiognomy, graphology etc. Bouts had a fragile health; therefore, it is unlikely that he travelled to Brazil. Despite this, his most famous book, rich in conservative and religious thoughts, was translated to Portuguese and published with ecclesiastic support in 1943, and the doctrine acquired good reputation among Brazilian members of the clergy, politicians, teachers, and military personnel. Lay scholars and medical doctors founded a Brazilian institute devoted to the study and diffusion of psychognomy in 1949. They published two volumes of a psychognomy treatise, and the institute was active until the early 1960s, when social interest in the subject rapidly vanished.
Characterization of the nigroestriatal system in a sample of patients with amyotrophic lateral sclerosis
Authors: Monsalve Claudio Alejandro Jimenez , Fornari Luis Henrique Tieppo , Júnior Neivo da Silva , Nakata Douglas Tomio , Neto Eurípedes Gomes de Carvalho , Rotta Francisco Tellechea , Rieder Carlos Roberto de Mello 
Published: October 2022

Abstract
Background The coexistence of amyotrophic lateral sclerosis (ALS) with clinical forms of Parkinson disease (PD), although uncommon, is found to a greater degree than one would expect by chance. The pathological mechanisms of ALS and PD are still not fully understood, and the coexistence of these two diseases suggests that they could share mechanisms in common.
Objective Here we present a sample of patients with clinically definitive or probable ALS who were evaluated with single-photon emission computed tomography SPECT/TRODAT and compared with non-ALS controls.
Methods Patients with clinically definite or probable ALS were assessed with the amyotrophic lateral sclerosis functional rating scale (ALSFRS) to define severity and had their demographic data collected. The TRODAT results of patients with ALS were compared with those of patients with a diagnosis of PD with less than 10 years of duration, and with patients with a diagnosis of others movement disorders not associated with neurodegenerative diseases.
Results A total of 75% of patients with ALS had TRODAT results below the levels considered normal; that was also true for 25% of the patients in the control group without neurodegenerative disease, and for 100% of the patients in the PD group. A statistically significant difference was found between patients with ALS and the control group without neurodegenerative disease in the TRODAT values < 0.05.
Conclusions Our study fits with the neuropathological and functional evidence that demonstrates the existence of nigrostriatal dysfunction in patients with ALS. Further research to better understand the role of these changes in the pathophysiological process of ALS needs to be performed.
Validation of ketogenic diet adherence questionnaire: Keto-check
Authors: Neri Lenycia de Cassya Lopes , Sampaio Letícia Pereira de Brito 
Published: October 2022

Abstract
Background The ketogenic diet is a therapeutic option to control drug-resistant epileptic seizures and has difficult compliance standards due to adverse effects, psychosocial factors, or dietary restriction.
Objective To create and validate a ketogenic diet compliance questionnaire.
Methods Methodological study, convergent care. The instrument was analyzed (construct validation) by five judges during two cycles of the Delphi technique. The judges assessed the relevance and clarity by using the Likert scale with three levels and made suggestions. The validation of the instrument was calculated using the agreement rate and content validity index (CVI). The application by two nutritionists made it possible to test reproducibility using the Kappa coefficient. When comparing the classification with a template developed by the health professionals who cared for the patients in question, the Pearson correlation and Fisher exact tests were used. For the reliability test, self-applied data were collected and evaluated using Cronbach Alpha coefficient.
Results The questionnaire initially created with 11 multiple choice questions on a Likert scale was reduced to 10 questions with an agreement rate and the CVI classified as excellent after two rounds with judges. In the application of the tool, a kappa of 0.6087 was obtained, a Pearson that showed no significant difference between evaluators and a Cronbach α of 0.6483, with substantial consistency.
Conclusions This work resulted in the creation of an unprecedented and reliable questionnaire on adherence to the national ketogenic diet. Further studies should be performed to extrapolate the use of this questionnaire in different populations.
Occlusal Analysis in Natural Dentition: Systematic Review
Authors: Velásquez Byron , Rodríguez María , Mosquera Verónica , Álvarez Eddy , Chauca Luis , Mena Alexandra 
Published: October 2022

AbstractThis study aimed to evaluate the effectiveness of conventional occlusal analysis in contrast with digital occlusal analysis in natural dentition. Occlusal analysis allows the identification of normal and abnormal occlusal contact points that alter the craniomandibular cervical system. We searched for articles with keywords [[dental occlusion]], [[natural dentition]], [[occlusal adjustment]], [[Immediate Complete Anterior Guidance Development]] [[mastication]], [[bite force]], [[premature contact]], [[occlusal balance]] [[articulating paper]]], [[spray]], [[Occlusal contacts]], and [[bite strength]]. They were considered observational , odds ratio and case control studies. We found 189 items. After evaluating the abstracts and full texts of the articles, 10 papers met the inclusion criteria. It was found that occlusal analysis allows the identification of the relationship between poor occlusion and the sensitivity of the teeth due to occlusal trauma, which is also related to temporomandibular joint pain in dynamic occlusion. The contacts of greater strength were observed in nonfunctional cusps, 48%, without ruling out the functional cusps, 24%. Despite being the universal method of occlusal control to date, the use of joint paper, remains subjective compared to the digital occlusal control device. Posture is considered directly related to occlusal trauma and temporomandibular disorders; without proper occlusal analysis, a clear diagnosis of the patient's joint condition cannot be obtained. Digital occlusal analysis is more objective than traditional occlusal analysis.
The expulsion of Augusta Dejerine-Klumpke from the Salpêtrière Hospital: Pierre Marie's revenge
Authors: de Vieira Igor Vieira , Batista Filho Emerson Luis , Ferreira Matheus Gomes , Camargo Carlos Henrique Ferreira , Coutinho Léo , Walusinski Olivier , Teive Hélio Afonso Ghizoni 
Published: October 2022

AbstractAugusta Dejerine-Klumpke was ahead of her time, with extensive contributions to the field of neuroanatomy and neurology, achieving international recognition. Despite her great contribution to world neurology, she was expelled from the Salpêtrière hospital in 1917, due to the rivalry and mutual hatred between Pierre Marie and his rival Jules Déjerine, her husband and collaborator.
Consensus of the Brazilian Headache Society (SBCe) for the Prophylactic Treatment of Episodic Migraine: part I
Authors: Melhado Eliana Meire , Santos Paulo Sergio Faro , Kaup Alexandre Ottoni , Costa Aline Turbino Neves Martins da , Roesler Célia Aparecida de Paula , Piovesan Élcio Juliato , Sarmento Elder Machado , Theotonio Giselle Oliveira Martins , Campos Henrique Carneiro de , Fortini Ida , Souza Jano Alves de , Maciel Júnior Jayme Antunes , Segundo João Batista Alves , Carvalho João José Freitas de , Speziali José Geraldo , Calia Leandro Cortoni , Barea Liselotte Menke , Queiroz Luiz Paulo , Souza Marcio Nattan Portes , Figueiredo Marcos Ravi Cerqueira Ferreira , Costa Maria Eduarda Nobre de Magalhães , Peres Mário Fernando Prieto , Jurno Mauro Eduardo , Peixoto Patrícia Machado , Kowacs Pedro André , Rocha-Filho Pedro Augusto Sampaio , Moreira Filho Pedro Ferreira , Silva-Neto Raimundo Pereira , Fragoso Yara Dadalti 
Published: October 2022

AbstractThe Brazilian Headache Society (Sociedade Brasileira de Cefaleia, SBCe, in Portuguese) nominated a Committee of Authors with the aim of establishing a consensus with recommendations regarding prophylactic treatment for episodic migraine based on articles published in the worldwide literature, as well as personal experience. Migraine affects 1 billion people around the world and more than 30 million Brazilians. In addition, it is an underdiagnosed and undertreated disorder. It is well known within the medical community of neurologists, and especially among headache specialists, that there is a need to disseminate knowledge about prophylactic treatment for migraine. For this purpose, together with the need for drug updates and to expand knowledge of the disease itself (frequency, intensity, duration, impact and perhaps the progression of migraine), this Consensus was developed, following a full online methodology, by 12 groups who reviewed and wrote about the pharmacological categories of the drugs used and, at the end of the process, met to read and establish conclusions for this document. The drug classes studied were: anticonvulsants, tricyclic antidepressants, monoclonal anti-calcitonin gene-related peptide (anti-CGRP) antibodies, beta-blockers, antihypertensives, calcium channel inhibitors, other antidepressants (selective serotonin reuptake inhibitors, SSRIs, and dual-action antidepressants), other drugs, and polytherapy. Hormonal treatment and anti-inflammatories and triptans in minimum prophylaxis schemes (miniprophylaxis) will be covered in a specific chapter. The drug classes studied for part I of the Consensus were: anticonvulsants, tricyclic antidepressants, monoclonal anti-CGRP antibodies, and beta-blockers.
Pathogen Reduction Technologies and Their Impact on Metabolic and Functional Properties of Treated Platelet Concentrates: A Systematic Review
Authors: Tsalas Stavros , Petrou Eleni , Tsantes Andreas G. , Sokou Rozeta , Loukopoulou Electra , Houhoula Dimitra , Mantzios Petros G. , Kriebardis Anastasios G. , Tsantes Argirios E. 
Published: October 2022

AbstractPathogen reduction technologies (PRTs) such as Mirasol and Intercept were developed to eliminate transfusion-transmitted infections. The impact of PRTs on platelet function during the storage period, their effect on platelet storage lesions, and the optimal storage duration following PRTs have not been clearly defined. The aim of this study was to systematically review the existing literature and investigate the impact of PRTs on functional alterations of PRT-treated platelets during the storage period. The authors identified 68 studies suitable to be included in this review. Despite the high heterogeneity in the literature, the results of the published studies indicate that PRTs may increase platelet metabolic activity, accelerate cell apoptosis, and enhance platelet activation, which can subsequently lead to a late exhaustion of activation potential and reduced aggregation response. However, these effects have a minor impact on platelet function during the early storage period and become more prominent beyond the fifth day of the storage period. Large in vivo trials are required to evaluate the effectiveness of PRT-treated platelets during the storage period and investigate whether their storage can be safely extended to more than 5 days, and up to the traditional 7-day storage period.
Disruption of proteostasis causes IRE1 mediated reprogramming of alveolar epithelial cells
Authors: Katzen Jeremy , Rodriguez Luis , Tomer Yaniv , Babu Apoorva , Zhao Ming , Murthy Aditi , Carson Paige , Barrett Matthew , Basil Maria C. , Carl Justine , Leach John P. , Morley Michael , McGraw Matthew D. , Mulugeta Surafel , Pelura Timothy , Rosen Glenn , Morrisey Edward E. , Beers Michael F. 
Published: October 2022

Disruption of alveolar type 2 cell (AEC2) protein quality control has been implicated in chronic lung diseases, including pulmonary fibrosis (PF). We previously reported the in vivo modeling of a clinical surfactant protein C (SP-C) mutation that led to AEC2 endoplasmic reticulum (ER) stress and spontaneous lung fibrosis, providing proof of concept for disruption to proteostasis as a proximal driver of PF. Using two clinical SP-C mutation models, we have now discovered that AEC2s experiencing significant ER stress lose quintessential AEC2 features and develop a reprogrammed cell state that heretofore has been seen only as a response to lung injury. Using single-cell RNA sequencing in vivo and organoid-based modeling, we show that this state arises de novo from intrinsic AEC2 dysfunction. The cell-autonomous AEC2 reprogramming can be attenuated through inhibition of inositol-requiring enzyme 1 (IRE1α) signaling as the use of an IRE1α inhibitor reduced the development of the reprogrammed cell state and also diminished AEC2-driven recruitment of granulocytes, alveolitis, and lung injury. These findings identify AEC2 proteostasis, and specifically IRE1α signaling through its major product XBP-1, as a driver of a key AEC2 phenotypic change that has been identified in lung fibrosis.
Kinetics driving nanocomposite thin-film deposition in low-pressure misty plasma processes
Authors: Chouteau S , Mitronika M , Goullet A , Richard-Plouet M , Stafford L , Granier A 
Published: October 2022

Abstract
Mist-assisted methods have recently attracted much attention for plasma deposition in high-quality (multi)functional thin films. However, very little is known on plasma interactions with misted colloidal solutions and their role in plasma process kinetics. Time-resolved optical diagnostics have been carried out to study the deposition of TiO2–SiO2 nanocomposite thin films in low-pressure oxygen-argon plasmas with organosilicon precursors and TiO2 suspensions. Each pulsed injection of the dispersion was followed by a pressure rise due to solvent evaporation. This caused a significant reduction in the electron temperature and density, which mitigated matrix precursor fragmentation and SiO2 deposition as TiO2 nanoparticles were supplied to the film. Comparing injections with and without nanoparticles, misty plasma effects were dominated by plasma droplets rather than plasma-nanoparticle interactions. Successive matrix-rich and nanoparticle-rich deposition steps were confirmed by in situ spectroscopic ellipsometry.
Remarkable enhancement in catechol sensing by the decoration of selective transition metals in biphenylene sheet: A systematic first-principles study
Authors: Mahamiya Vikram , Dewangan Juhee , Shukla Alok , Chakraborty Brahmananda 
Published: October 2022

Abstract
Motivated by the recent successful synthesis of biphenylene structure (Fan et al 2021 Science
372 852), we have explored the sensing properties of this material towards the catechol biomolecule by performing the first-principles density functional theory and molecular dynamics simulations. Pristine biphenylene sheet adsorbs catechol molecule with a binding energy of −0.35 eV, which can be systematically improved by decorating the transition metals (Ag, Au, Pd, and Ti) at various possible sites of biphenylene. It is observed that the catechol molecule is adsorbed on Pd and Ti-decorated biphenylene sheets with strong adsorption energies of −1.00 eV and −2.54 eV, respectively. The interaction of the catechol molecule with biphenylene and metal-decorated biphenylene is due to the charge transfer from the O-2p orbitals of the catechol molecule to the C-2p orbitals of biphenylene and d-orbitals of metals in metal-decorated biphenylene, respectively. From the Bader charge calculation, we found that 0.05e amount of charge is transferred from the catechol molecule to pristine biphenylene, which gets almost double (∼0.1e) for the Ti-decorated biphenylene sheet. The diffusion energy barrier for the clustering of the Pd and Ti atoms comes out to be 2.39 eV and 4.29 eV, computed by performing the climbing-image nudged elastic band calculations. We found that the catechol molecule gets desorbed from the pristine biphenylene sheet at 100 K but remains attached to metal (Pd, Ti) decorated biphenylene sheets at room temperature by performing the ab-initio molecular dynamics simulations. The Ti-decorated biphenylene sheet has more sensitivity toward catechol adsorption while the Pd-decorated biphenylene sheet has a suitable recovery time at 500 K. The results suggest that the Pd and Ti-decorated biphenylene sheets are promising materials for catechol detection.
Controlling the electronic and magnetic properties in epitaxial LaMnO3/LaScO3 superlattices
Authors: Wei Haoming , Chen Xin , Wu Yangqiang , Cao Bingqiang 
Published: October 2022

Abstract
Perovskite superlattices (SLs) have attracted considerable interest owing to their rich and diverse physical properties. In this study, epitaxial LaMnO3/LaScO3 SLs were grown using pulsed laser deposition (PLD) by controlling the number of atomic monolayers. Raman spectroscopy combined with x-ray diffraction reciprocal space maps confirmed that the introduction of LaScO3 suppressed Jahn–Teller distortion in the SLs. Electrical transport measurements revealed a thermally activated single-gap behavior which mainly depended on the thickness of LaMnO3 layers. Magnetic measurements indicated that the magnetic properties of the SLs were related to the proportions of LaMnO3 and LaScO3 layers. These results are beneficial for the further understanding of the electronic and magnetic properties of LaMnO3-based SLs.
Optimal large time behaviour of the 3D compressible magnetohydrodynamics equations with large initial data
Authors: Wu Guochun , Wang Juan , Zhang Yinghui 
Published: October 2022

Abstract
We investigate time-decay rates of strong solutions to the 3D compressible magnetohydrodynamics equations with large initial data. The main novelty of this paper is two-fold: first, we prove the upper optimal decay rates of the higher-order spatial derivatives of the solution, which are the same as those of the heat equation, and faster than the decay rates in the previous related works. Second, if the initial data satisfy some additional low frequency assumption, we also show the lower optimal decay rates of the solution as well as its all-order spatial derivatives. Therefore, our decay rates are optimal in this sense. Our methods mainly involve the Fourier splitting method, low-frequency and high-frequency decomposition and delicate energy estimates.
Manifesting hidden dynamics of a sub-component dark matter
Authors: Kamada Ayuki , Kim Hee Jung , Park Jong-Chul , Shin Seodong 
Published: October 2022

Abstract
We emphasize the distinctive cosmological dynamics in multi-component dark-matter
scenarios and their impact on probing a sub-dominant component of dark matter. The dynamics
originate from the conversion among different dark-matter components. We find that the
temperature of the self-interacting sub-component dark matter is significantly enhanced by the
dark-matter annihilation into the sub-component. The same annihilation sharply increases the
required annihilation cross section for the sub-component as we consider a smaller relative
abundance fraction among the dark-matter species. Because of the enhanced temperature and
couplings of the sub-component, contrary to a naive expectation, the sub-component with smaller
abundance fractions tends to be disfavored by dark-matter direct/indirect-detection experiments
and cosmological observations. We demonstrate this by taking a dark photon portal scenario for
the sub-component at the sub-GeV mass scale. For the abundance fraction ≳ 10 %,
the enhanced temperature of the sub-component is subject to warm dark matter constraints which are
complementary to the parameter space probed by accelerator-based experiments. Smaller abundance
fractions tend to be disfavored by accelerator-based experiments due to the enhanced coupling to
Standard Model particles.
Conformal metric-affine gravities
Authors: Olmo Gonzalo J. , Orazi Emanuele , Pradisi Gianfranco 
Published: October 2022

Abstract
We revisit the gauge symmetry related to integrable projective transformations in metric-affine formalism, identifying the gauge field of the Weyl (conformal) symmetry as a dynamical component of the affine connection. In particular, we show how to include the local scaling symmetry as a gauge symmetry of a large class of geometric gravity theories, introducing a compensator dilaton field that naturally gives rise to a Stückelberg sector where a spontaneous breaking mechanism of the conformal symmetry is at work to generate a mass scale for the gauge field. For Ricci-based gravities that include, among others, General Relativity, f(R) and f(R, R
μν
R
μν) theories and the EiBI model, we prove that the on-shell gauge vector associated to the scaling symmetry can be identified with the torsion vector, thus recovering and generalizing conformal invariant theories in the Riemann-Cartan formalism, already present in the literature.