bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time kill-assays of antibiotic combinations for multidrug resistant clinical isolates of OXA-48 carbapenemase producing Klebsiella pneumoniae
Authors: Erdem Fatma , Díez-Aguilar María , Oksuz Lutfiye , Kayacan Cigdem , Abulaila Ayham , Oncul Oral , Morosini María Isabel , Cantón Rafael , Aktas Zerrin 
Published: September 2022

Abstract
Treatment of infections caused by OXA-48 carbapenemase producing multidrug-resistant isolates often necessitates combination therapy. In vitro effect of different antibiotic combinations against multidrug-resistant (MDR) Klebsiella pneumoniae isolates were evaluated in this study.
Meropenem-tobramycin (MER+TOB), meropenem-ciprofloxacin (MER+CIP), colistin-meropenem (COL+MER), colistin-ciprofloxacin (COL+CIP) and colistin-tobramycin (COL+TOB) combinations were tested by time kill-assays. Each antibiotic alone and in combination at their Cmax values were tested against 4 clinical K. pneumoniae isolates at 1, 2, 4, 6, 8, 12 and 24 h. Effect of colistin and its associations were also assessed at 30 min. Bactericidal activity was defined as ≥3log10 CFU mL−1 decrease compared with initial inoculum. Synergy was defined as ≥2log10CFU mL−1 decrease by the combination compared with the most active single agent. Presence of bla
OXA-48, bla
NDM, bla
VIM, bla
IMP, bla
KPC and bla
CTX-M-1 genes was screened by PCR using specific primers.
The bla
OXA-48 gene was identified together with bla
CTXM-1 group gene in all isolates. COL+MER demonstrated to be synergistic and bactericidal. MER+TOB showed synergistic and bactericidal effect on two strains although, regrowth was seen on other two strains at 24 h. MER+CIP exhibited indifferent effect on the strains.
Combination therapy could be a potential alternative to treat MDR K. pneumoniae infections. This combination might prevent resistance development and secondary effects of colistin monotherapy. MER+TOB and MER+CIP might have an isolate-dependent effect, that may not always result in synergism.
Another failure of the latent disease model? The case of compulsive sexual behavior disorder •
Authors: Borgogna Nicholas C. , Aita Stephen L. 
Published: September 2022

Abstract
Recent debates have evolved regarding the classification/conceptualization of compulsive sexual behavior disorder (CSBD). Conclusions regarding an agreed upon CSBD model are hindered by reliance on the latent disease model. Competing biological-based frameworks are moving forward to replace latent disease classification more broadly but have been met with limited success. We suggest that CSBD researchers move towards developing dimensional, transtheoretical, process-based models. We further suggest additional research, particularly mixed methods and longitudinal studies. Finally, we request that federal funding bodies take a more active role in supporting CSBD research.
Organic crystal structure prediction and its application to materials design
Authors: Zhu Qiang , Hattori Shinnosuke 
Published: September 2022

AbstractIn recent years, substantial progress has been made in the modeling of organic solids. Computer simulation has been increasingly shaping the area of new organic materials by design. It is possible to discover new organic crystals by computational structure prediction, based on the combination of powerful exploratory algorithms and accurate energy modeling. In this review, we begin with several key early concepts in describing crystal packing, and then introduce the recent state-of-the-art computational techniques for organic crystal structure prediction. Perspectives on the remaining technical challenges, functional materials screening and software development are also discussed in the end. It is reasonable to expect that, in the near future, accurate predictive computational modeling can be accomplished within a time frame that is appreciably shorter than that needed for the laboratory synthesis and characterization.
Graphical abstract
PEMBERDAYAAN MASYARAKAT PENGRAJIN GRABAH KASONGAN DI TENGAH PANDEMI COVID-19
Authors: Irma Tiza , Atmojo Muhammad Eko 
Published: September 2022

This study aims to see community empowerment in strengthening MSMEs for pottery craftsmen in Kasongan, Bantul in the midst of the COVID-19 pandemic. Because as is known that the COVID-19 pandemic is enough to cause a multidimensional crisis that has a very significant impact on economic movements. So that this economic sector feels a considerable impact from the COVID-19 pandemic, coupled with the various policies carried out by the Indonesian government. One of the affected sectors is the MSME sector located in Kasongan, Bantul. During the COVID-19 pandemic, MSME players, especially the pottery craftsmen MSME group, were also affected where there was a decrease in pottery sales turnover and also a decrease in pottery production. However, the pottery craftsman MSME group was able to survive amid the uncertainty of the covid-19 pandemic. This is certainly influenced by several things, one of which is the efforts of the village government itself in empowering the community in strengthening MSMEs. Therefore, to determine community empowerment in strengthening MSMEs in the midst of the COVID-19 pandemic, researchers used qualitative research methods with descriptive analysis. So that it can see the social phenomena that occur directly and more deeply. From this study, the results were obtained that if you look at the empowerment of the three phases of empowerment, namely the Initial Phase, the Participatory Phase, and the Emancipatory Phase, then the empowerment of the community in Bangunjiwo for pottery MSME actors can be said to be successful. So that with these 3 phases, it can strengthen Kasongan pottery craftsmen to survive in the midst of the COVID-19 pandemic
Água e espaços transfronteiriços na América do Sul:
Authors: Rio Gisela A. Pires do , Drummond Helena 
Published: September 2022

Muitos países permanecem reticentes Ã implantação de novas institucionalidades e arenas de negociações participativas em espaços transfronteiriços. Assumindo-se a existência de dinâmica transfronteiriça peculiar, o presente trabalho apresenta e discute questões sobre gestão de água em espaços transfronteiriços, a fim suscitar debates sobre situações efetivas de cooperação/conflito transfronteiriços na América do Sul. Partimos do pressuposto de que uma turbulência de escalas é característica dessas áreas. Entende-se por turbulência de escalas a possibilidade de manifestação de cooperação, tensões, conflitos e disputas em múltiplas escalas. Recorrendo a exemplos recentemente discutidos na literatura geográfica em diferentes regiões do mundo, foram definidos parâmetros para refletir sobre a realidade sul-americana. Esses parâmetros referem-se Ã s manifestações de concordância e discordância da implantação de dispositivos de gestão de águas por bacias hidrográficas. Complementa o levantamento bibliográfico, a análise de documentação de organismos internacionais, tendo em vista a identificação de situações que se projetaram em várias escalas geográficas. O interesse do trabalho reside na apresentação de questões próprias ao contexto sul americano, como proposta de agenda para reflexão. Nas considerações finais são apresentados os desafios que nos parecem mais significativos para a construção de proximidades institucionais nos espaços transfronteiriços.
THE ECHOES OF GENOCIDAL CONFLICTS IN THE KITE RUNNER BY KHALED HUSSEINI
Authors: Khan Saood , Amina Sidra , Sarwar Maryam , Shah Sayed Mujeeb Ullah , Khan Afaqullah 
Published: September 2022

Purpose of the Study: The discourse aims to diagnose the causes of genocidal conflict between Pashtuns and Hazaras. It also aims to analyze the power exercised by the Pashtuns who have subjugated and marginalized the Hazaras since the 1221 century.
Methodology: The theoretical framework employed in the study is Critical Discourse Analysis (CDA) (Fairclough, 2001). Fairclough’s three-dimensional model is implemented to reflect the nature of social practices which comprises an understanding of discourse as a text (micro-level) discourse practice (Meso-level) and socio-cultural practice (macro-level).
Main Findings: The result of the study shows that Hazaras became the victim of the Genocidal conflict owing to their prior historical battle fought Between Khawarzamis (ancestors of Pashtuns) and Mongols (ancestor of Hazaras) in 1221CE. In the war Mongols loathed Khawazamis as a result it adopted the shape of a genocidal conflict. With passing years, it coloured in many ways such as in the shape of cultural, socioeconomic, and religiopolitical conflicts, which in turn marginalized, subalternate, Othered, and killed thousands of Hazaras, and the conflict is still unstoppable.
Application of this Study: Since different books, websites, as well as the novel The Kite Runner, have been critically examined for a better understanding of the concept of genocidal conflict which is very helpful to understand the stance of genocidal conflict and the factors that prompt genocidal conflict. It can be helpful in sociology in political studies for power balance in society.
Formation of readiness of future teachers-psychologists for the organization of psycho-diagnostic activity
Authors: Rapikova Sandugash , Kosherbayeva Aygerim , Iskakova Marzhan , Amangul Orakova , Sholpan Abisheva , Aigerim Amantayeva 
Published: September 2022

The aim of this research is to get the opinions of psycho-diagnostic activity on the vocational training of educational psychologists of the trainings given at the university for the organization of psychodiagnostic activities in the educational environment. With the findings to be obtained from this research, it can be concluded that the efficiency of the pedagogical activity and the education of the future occupational groups can be effective. Qualitative research design was used in this study. The psychodiagnostic readiness levels of teacher candidates studying at university were measured. The study group of the research consists of 78 senior students studying at the faculty of education at universities. The research questions were applied with the permission of the ethics committee. In the spring semester of 2021-2022, a working group was formed with the last year teacher candidates studying at the education faculties of two universities. The findings obtained from the research were analyzed with the content analysis method. According to the results of the research, it was concluded that the readiness of the people who will do the teaching profession should be increased by increasing the psychological knowledge in teacher education in educational institutions.
Keywords: Formation, university, pre-service teacher, psychological, psycho-diagnostic
Biomarcadores y síndrome de burnout en estudiantes universitarios del área de la salud.
Authors: Cortés Espinosa Juan David , Chávez Torres Ninfa Marlén , Zárate Herrán Angélica , Doncel Andrés Felipe 
Published: September 2022

El objetivo de esta revisión fue sintetizar la información publicada en los últimos 10 años acerca de los biomarcadores de estrés empleados para medir esta condición en los estudiantes de ciencias de la salud y su relación con las escalas de estrés subjetivo agudo y crónico. Se realizaron búsquedas sistemáticas en Pubmed, Science Direct, Scopus y Lilacs, encontrado 112 artículos, de los cuales se incluyeron 17 que cumplieron con los criterios de inclusión. Los resultados muestran que el cortisol sérico y salival fue el biomarcador más utilizado y las escalas STAI, VASS y la escala de sucesos estresantes, son las que mejor se relacionan con niveles de cortisol en los estudios incluidos en esta revisión. Sim embargo consideramos que la información obtenida no es suficiente para establecer una correlación significativa entre los niveles de biomarcadores de estrés y de estrés percibido medido por escalas autoreferidas.
ANALISIS KEPERCAYAAN DIRI PADA KORBAN BULLYING
Authors: Moh Anang Zulqurnain  , Mohammad Thoha  
Published: September 2022

Penelitian ini dilatarbelakangi oleh banyaknya tindakan bullying di kalangan remaja atau siswa, hal ini disebabkan kurangnya pengawasan guru terhadap siswa terhadap bullying sehingga hal tersebut akan berdampak pada kepercayaan diri siswa. Tujuan dari peneliti ini adalah untuk mengetahui kepercayaan diri pada siswa korban bullying di SMP Al-Hakim Sampang. Berdasarkan hal tersebut, ada tiga fokus peneliti yang menjadi acuan kajian peneliti ini, yaitu: pertama, bagaimana gambaran perilaku bullying di SMP Al Hakim Sampang? Kedua, bagaimana dampak perilaku bullying terhadap kepercayaan diri siswa di SMP Al Hakim Sampang? Ketiga, apakah bapak/ibu guru sudah berupaya untuk meningkatkan kepercayaan diri siswa akibat perilaku bullying di SMP Al Hakim Sampang?. Penelitian ini menggunakan metode penelitian kualitatif, prosedur pengumpulan data yang digunakan oleh peneliti dantaranya wawancara, observasi, dokumentasi. Sedangkan dalam analisis data meliputi reduksi data penyajian data, dan kesimpulan. Kemudian dalam proses pengecekan keabsahan data hasil penelitan melalui perpajang keikutsertaan, ketekunan dalam proses pengamatan, dan yang terakhir melalui triangulasi. Hasil dari penelitian ini menunjukkan bahwa: Pertama, Gambaran perilaku bullying siswa kelas VIII yaitu berawal dari saling ejek-ejekan yang berkelanjutan sehingga menimbulkan pelaku kekerasan atau bullying fisik. Hasil angket menunjukkan perilaku bullying fisik 80 dengan presentase 54% lebih banyak dari perilaku bullying lainnya, kemudian bullying verbal dengan skor 43 dengan presentase 29% menjadi perilaku bullying terbanyak yang kedua, kemudian bullying rasional dengan skor 16 presentase 11%, diurutan terakhir bullying elektronik/cyber bullying dengan skor 9 presentase 6%. Kedua, Dampak perilaku bullying terhadap kepercayaan diri siswa. Dampak yang terjadi pada kepercayaan diri anak bermacam-macam, seperti anak suka menyendiri, tidak semangat untuk belajar, kurang aktif di dalam kelas, tidak pernah bergabung dengan teman lainnya, sering tidak masuk sekolah bahkan ada yang ingin berhenti sekolah. Ketiga, upaya guru untuk meningkatkan kepercayaan diri siswa akibat perilaku bullying di SMP Al Hakim Sampang yaitu jika ada yang melakukan perilaku bullying guru langsung memanggil pelaku maupun korban bullying untuk menanganinya, bagi korban dikasih motivasi agar kepercayaan dirinya kembali kembali lagi dan untuk pelaku dikasih teguran dan diberi hukuman sesuai dengan pelanggarannya, agar perilaku bullying tidak sering terjadi lagi.
Histamine intolerance (HIT)
Authors: Matysiak Joanna 
Published: September 2022

Histamine intolerance (HIT) is food intolerance of non-immunological origin, and it results from an imbalance between the consumption of histamine with food and the organism ability to metabolize it. The patients with HIT were found to have a significantly reduced concentration of histamine-degrading enzymes, diamine oxidase (DAO) and histamine N-methyltransferase (HNMT). Factors which have been identified that are conducive to histamine intolerance are: genetic factors, dysbacteriosis, chronic diseases – especially allergic and intestinal diseases, chronic infections, mastocytosis and some drug use. Clinical symptoms of histamine excess may affect various organs and systems - the most common are skin symptoms (pruritis, erythema) nausea, vomiting, abdominal pain, diarrhea, headaches and sometimes severe reactions with shortness of breath, arrhythmias, blood pressure drop, and even cardiac arrest.
Diagnostic methods in HIT utilize determination of serum DAO, determination of histamine metabolites in urine, measurement of the histamine wheal in the 50th minute of the skin prick test (SPT), gastroscopy with intestinal biopsy, diagnostic and therapeutic test, oral histamine-challenge test and genetic tests.
The mainstay of histamine intolerance treatment if a low-histamine diet. Patients should avoid products belonging to the three groups of food: containing large amounts of histamine, histamine liberators, and products inhibiting the activity of DAO. Additionally, supplements containing DAO and antihistamines can be used.
Pengaruh Keaktifan Organisasi Terhadap Prestasi Akademik Mahasiswa Fakultas Kedokteran
Authors: Luailiyah Afridatul , Zadal Hilmi Akbar , Sahariani Menik 
Published: September 2022

Background: The activeness of students in organizations is considered as one of the things that influences the learning achievement of students. Participating in organizations can also make students have experience and practice management. Medical students are required to master seven areas of competence including noble professionalism, insight and personal development, effective communication, information management, scientific foundation of medical science, clinical skills and management of health problems. These competencies can be achieved through academic learning or intra and extracurricular activities. The purpose of this study was to determine the effect of the level of organizational activeness with a cumulative achievement index (CAI) for students of the medical faculty of Unissula Semarang.
Methods: Analytic observational research with pre-posttest design. A total of 111 students of the medical faculty of Unissula Semarang class of 2016 were the subject of this study. Organizational activity was assessed by a questionnaire containing 12 questions about the quantity of organization. The CAI value of semester 2 and 6 and its difference were used. The effect of organizational activity on CAI was analyzed by the Wilcoxon and Kruskal Wallis tests.
Results: The GPA value for semester 6 was significantly higher than in semester 2 for all of the organizational activities level includes low, medium and high categories (p <0.05). However, the increase in the value of the CAI was not related to the organizational activity level (p> 0.05).
Conclusion: The level of activeness in organizing has no effect on the CAI of students of the medical faculty of Unissula Semarang.
Tingkat Pemahaman Mengenai COVID-19 dan Kepatuhan Pemeriksaan Kehamilan (ANC) : A Cross Sectional
Authors: Larasati Raden Rara Pandhan Budi , Laqif Abdurahman , Melinawati Eriana , Aryoseto Lukman 
Published: September 2022

Pendahuluan: Ante natal care (ANC) dilakukan untuk mengetahui perkembangan janin dan kesehatan ibu hamil. Ketidakpatuhan memenuhi jadwal pemeriksaan ANC meningkatkan risiko terjadinya komplikasi kehamilan dan persalinan, Angka Kematian Ibu (AKI), dan Angka Kematian Bayi (AKB). Protokol kesehatan (prokes) di masa pandemi COVID-19 memberlakukan stay at home (tetap tinggal di rumah) dan social distancing (menjaga jarak). Ibu hamil merupakan individu yang rentan terhadap infeksi COVID-19. Keterbaharuan penelitian melihat pengaruh pengetahuan ibu hamil terhadap kepatuhan melakukan pemeriksaan ANC. Tujuan untuk mengetahui pengaruh tingkat pengetahuan mengenai COVID-19 terhadap kepatuhan subjek melakukan pemeriksaan ANC di masa pandemi COVID-19.
Metode: Design penelitian adalah cross-sectional study dengan wawancara pada ibu hamil yang datang ANC saat masa pandemi COVID-19 di Puskesmas Cawas 1, Klaten yang memenuhi kriteria inklusi dan eksklusi. Kelengkapan data diperoleh dengan pengisian kuesioner yang telah divalidasi dan catatan dari buku KIA. Olah data univariat dan bivariat dengan menggunakan uji Chi-Square.
Hasil: Jumlah responden sebanyak 66 orang dengan 77,3 % (51/66) berusia antara 20-35 tahun, 75,8% (50/66) berpendidikan tinggi, dan 69,7% (46/66) merupakan ibu yang tidak bekerja. Tidak terdapat pengaruh tingkat pengetahuan mengenai COVID-19 terhadap kepatuhan pemeriksaan kehamilan (ANC) dalam masa pandemi di Puskesmas Cawas 1, Klaten, dengan p value 0,673.
Kesimpulan: Tidak ada pengaruh tingkat pengetahuan COVID-19 terhadap kepatuhan ANC di masa pandemi di Puskesmas Cawas 1, Klaten.
Development of E Module Based on Android in Basic Graphics Design Course
Authors: Subastian Moh Dycki , Astuti Cindy Cahyaning 
Published: September 2022

This study aims to development and feasibility of e modul based on Android in the basic subjects of graphic design for class X Multimedia at SMK PGRI 2 Sidoarjo. This research was conducted at SMK PGRI 2 Sidoarjo with research subjects in class X Multimedia who received Basic Graphic Design subjects. In this study are research and development method of R and D uses the ADDIE model which consists of analysis, design, development, implementation, and evaluation. However, in this study, only three stages were applied, namely the analysis, design, development stages, while the implementation dissemination and evaluation stages were not carried out due to the limited time of the study and the impact of the Covid 19 outbreak. The android-based e-module has met the validity criteria by obtaining an average score from all aspects of the assessment, the media expert validator is 88 percent which is in the category suitable for use with revisions, and the material expert validator is 74 percent in the category suitable for use with revisions so that based on the assessment experts have been appropriate and suitable to be used as learning media in Basic Graphic Design subjects
Nonlinear Analysis by Applying Best Approximation Method in p-Vector Spaces
Authors: YUAN George X. 
Published: September 2022

Abstract
It is known that the class of p-vector spaces (0 < p ≤ 1) is an important generalization of usual norm spaceswith rich topological and geometrical structure, but the most tools and general principles with nature in nonlinearity have not been developed yet, the goal of this paper is to develop some useful tools in nonlinear analysisby applying the best approximation approach for the classes of 1-set contractive set-valued mappings in p-vectorspaces. In particular, we first develop the general fixed point theorems of condensing mappings which provideanswer to Schauder conjecture in 1930’s in the affirmative way under the setting of p-vector spaces. Then one bestapproximation result for upper semi-continuous and 1-set contractive set-valued is established, which is used as auseful tool to establish fixed points of non-self set-valued mappings with either inward or outward set conditions,and related various boundary conditions.
AMS Classification: 47H04, 47H10, 46A16, 46A55, 49J27, 49J35, 52A07, 54C60, 54H25, 55M20