bluuebunny/crossref_metadata_2025_split huggingface dataset:
The public’s attitude to and acceptance of periodic doses of the COVID-19 vaccine: A survey from Jordan
Authors: Abuhammad Sawsan , Khabour Omar F. , Alzoubi Karem H. , Hamaideh Shaher , Alzoubi Baker A. , Telfah Waed S. , El-zubi Farah K. 
Published: July 2022

Aims
This study surveyed people regarding their acceptance of periodic doses (i.e., annual boosters) of the COVID-19 vaccine. Moreover, factors that correlate with attitudes toward periodic COVID-19 vaccines were assessed and identified.

Method
The study employed a cross-sectional methodology. The study questionnaire was distributed using Google Forms. Data were collected during the last quarter of 2021, and 1,416 adults (18 years old and over) from Jordan responded. Acceptance of COVID-19 periodic vaccine doses was calculated as a percentage of the total number of study participants, and their attitudes were scored. A multiple regression model was used to determine the predictors of public attitudes toward the annual dose of COVID-19 vaccines.

Results
The acceptance rate for receiving periodic doses of the COVID-19 vaccine was low (19.3%). Additionally, 26% of participants were unsure about receiving additional doses of the vaccine. However, 54.7% had a negative attitude toward getting periodic doses. The mean score for attitudes toward periodic doses was 47.9 (range: 29–66). Among the identified factors leading to decisions not to receive periodic doses were side effects (49.1%), waiting for further clinical studies (38.8%), and perceived no risk of contracting COVID-19 (17.7%). Regression analysis showed that income, educational attainment, and following the news about COVID-19 were predictors of participants’ attitudes toward the periodic COVID-19 vaccine.

Conclusion
Acceptance of periodic doses of the COVID-19 vaccine in Jordan is low, and the public’s attitude is generally negative. Health programs and educational interventions are needed to promote vaccine acceptance and positive attitudes.
Association between life events and later depression in the population-based Heinz Nixdorf Recall study—The role of sex and optimism
Authors: Gronewold Janine , Duman Ela-Emsal , Engel Miriam , Engels Miriam , Siegrist Johannes , Erbel Raimund , Jöckel K-H. , Hermann Dirk M. 
Published: July 2022

Background
The association between life event stress and depressive symptoms has not been analyzed in the general population before.

Methods
In the population-based Heinz Nixdorf Recall study, we assessed the association of 1.) the presence of important life events and 2.) life event stress, with the amount of depressive symptoms in univariable linear regressions and in multivariable regressions adjusted for age and sex (model 1) and age, sex and optimism as important determinants of coping with life events (model 2). Presence of life events and life event stress were assessed with the Social Readjustment Rating Scale (SRRS), optimism with the Life Orientation Test-Revised (LOT-R), and depressive symptoms with the 15-item Center for Epidemiological Studies Depression Scale (CES-D).

Results
Of the total cohort of 4,814 participants, 1,120 had experienced important life events during the previous 6 months. Presence of important life events was significantly associated with higher CES-D scores (B = 2.6, 95%CI = 2.2 to 3.0, p < .001; model 2) compared to absence of life events. Associations were stronger for women than for men and for pessimists than for optimists. Among the participants with important life events, median (Q1; Q3) stress-score was 45.0 (39.0; 63.0). Stress-scores >Q3 were significantly associated with higher CES-D scores (2.2, 1.1 to 3.3, < .001) with a stronger association in pessimists than in optimists.

Conclusions
Experiencing life-changing events is associated with depression. Women and individuals with pessimistic personality are especially vulnerable which should be considered in prevention strategies.
The charophytes (Characeae, Charophyceae) from the Yenisey Siberia (Russia)
Authors: Romanov Roman E. , Efimov Denis Yu. , Makeeva Evgeniya G. , Shaulo Dmitriy N. , Kipriyanova Laura M. , Zotina Tatiana A. , Pospelov Igor N. , Ebel Alexandr L. , Zarubina Evgeniya Yu. , Polyanskaya Dana Yu. 
Published: July 2022

The records of new localities of charophytes from the Yenisey Siberia and confirmations for the ones known before were summarized as a result of study both available herbarium collections and field studies during 2007–2021. The twenty species, including one novel genus and five novel species records, 59 new localities (67 % of its total number), 127 new populations (83 % of its total number) were found in this region. In particular, 12 species (incl. 3 novel ones for the region) are known from the Republic of Khakassia, 17 (7) – from the Krasnoyarsk Territory, 12 (7) – from the Tuva Republic. The genus Chara is the most species-rich and frequent in the area of study. The taxonomic rank of C. arcuatifolia sensu Hollerb. et Krassavina is discussed. It seems to be a morphotype of C. globularis having clearly arcuate branchlets. Nitella tenuissima is a novel species record for Asian Russia. The charophyte northernmost locality on the continent was revealed. It belongs to C. virgata collected at Southern Taymyr. The novel locality of circumpolar species Tolypella canadensis, far distant from ones known before from Komi Republic and Republic of Yakutia, was found in this region too. The species occurrence in different ecoregions was estimated. The contemporary presence of some species after long intervals between observations from their first records was confirmed. The persistence of the same species in the same water bodies after a long period was revealed as evidence of stability of their populations, important for species protection. The loss of charophyte localities as a result of construction of large Krasnoyarskoe and Sayano-Shushenskoe water reservoirs is remarkable. The red lists for the regions studied were compiled and some species were suggested for protection. The important charophyte areas enabling protection of some species were revealed.
Three new species of Polystichum (Dryopteridaceae) from China
Authors: Jiang Ri-Hong , Чжан Сянь-Чунь 
Published: July 2022

Three new species of Polystichum (Dryopteridaceae), P. paramartini R. H. Jiang et X. C. Zhang, P. sublanceolatum R. H. Jiang et X. C. Zhang, and P. venosum R. H. Jiang et X. C. Zhang, are described and illustrated. They are all from the limestone mountains in South and Southwest China. The first two species are found in limestone caves while the third one occurs on limestone mountain slopes. Detailed descriptions, line drawings, ecological preferences, conservation status are provided.
In Silico Analysis Prediction of B-Cell Epitope as a Vaccine Candidate for SARS-CoV-2 B.1.617.2 (Delta) Variant
Authors: Wattimena Mauritz Nicolaas , Wijanarka Wijanarka 
Published: July 2022

Background: The COVID-19 pandemic by SARS-CoV-2 has caused many losses. One way to prevent the spread of this virus is to get vaccinated. However, the latest SARS-CoV-2 variants, including variant B.1.617.2 (Delta) are doubtful to be inhibited by existing vaccines because of mutations. Therefore, we need a new vaccine candidate that is effective against this SARS-CoV-2 variant. Through an immunoinformatics approach with various software and analysis websites, vaccine candidates can be predicted in a short time.Objective: Identity, analyze, obtain, and confirm the selected B-cell epitope sequence that can be used as a vaccine candidate for the SARS-CoV-2 B.1.617.2 (Delta) variant.Methods: This research was conducted by isolating the amino acid peptide sequence in the SARS-CoV-2 B.1.617.2 (Delta) variant protein spike from the Protein Data Bank which is suspected to be an immunogenic epitope and can be used as a vaccine candidate. A Series of tests were carried out such as antigenicity, toxicity, allergenicity, and BLAST® protein to ensure that this vaccine candidate is safe for later application into the human body. The next stage is a conservation analysis to see its potential by comparing it with the SARS-CoV-2 Delta (B.1.617.2) variant spike protein sequence in Indonesia. The study ended by mapping amino acid peptides to the SARS-CoV-2 Delta (B.1.617.2) variant spike protein using the Biovia Discovery Studio Visualizer v21.1.0.20298 2020 software to ensure that the selected sequences were epitope.Results: From the five amino acid peptides that have been isolated, the FTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFT epitope sequence has good results than the others. It is probable an antigen, non-toxic, non-allergen, and non-homolog to the human body protein.Conclusion: Based on this in silico study, it was found that the FTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFT epitope sequence was the best to be used as a vaccine candidate of SARS-CoV-2 B.1.617.2 (Delta) variant.Keywords: SARS-CoV-2 B.1.617.2 (Delta) variant, B-cell epitope, vaccine, in silico, immunoinformatics.
The Discontinuation Effect of Topical Prednisolone on Extracellular Matrix Trabecular Meshwork in Wistar Rat
Authors: Kumalasari Sekar , Ekowati Liana , Wildan Arief , Istiadi Hermawan , Saubig Arnila Novitasari , Rahmi Fifin Luthfia 
Published: July 2022

ABSTRACT Background:Intra ocular pressure (IOP) elevationis one of topical steroids’ side effects. Corticosteroid will initiate matrix metalloproteinase cascade that leads to extra cellular matrix (ECM)of trabecular meshwork (TM) turnover(remodeling) and its acumulationin TM. Objective: To analyze the reversibility of ECM TM in Wistar rat after discontinuation oftopical prednisolone1% at different periode(14 days and 28 days). Methods:This was an experimental study with post test only controlgroup design. Total samples of 28 rats were divided into 4 groups: Treatment groups 1 was treated with topical prednisolone for 28 days, and was terminated 14 days after discontinuation of the drug.Treatment goups2 was treated topical prednisolone for 28 days and was terminated28 days after discontinuation of the drug. Control 1 was treated withtopical prednisolone for 28 days, and Control 2 was treated with topical saline for 28 days and terminated without periode of discontinuation. Histopathological grading score was used to evaluate ECM TM deposition. Mann-Whitney test and Kruskal-Wallis test were used to analyze the data. Result: Deposition of ECM in TM was not statistically different intreamentgroup 1 and treatment group 2 (p>0.05). Deposition of ECM in TM were statistically differentbetween treatment group 2 and control group 1 (p<0.05). Comparative test showed p<0.001,which means that there was a change in the thickness of ECM after discontinuation of instillation. Conclusion: ECM TM was thinner in the experimental animals with a longer duration of topical prednisolondiscontinuation, which demonstrate that maintenance remodeling of ECM was happen.
Realities and Impacts of Teaching Approach and Method in Bilingual Classroom in Indonesia
Authors: Khair Imamatul 
Published: July 2022

Pedagogical approach and methods are prominent in students’ engagement in second language learning. Strategies and scaffolds are two other interconnected issues that matter in bilingual classrooms. This study crafted some findings of pedagogical practices performed by bilingual teachers which may fall into accommodating or dumbing down bilingual learners’ needs. It is an ethnographic study which used class observations as data to find the realities of practices that teachers used for English language learners at the Indonesian college level. It revealed how a teacher stood for a certain method and pedagogical approach to negotiate instructional strategies within a bilingual classroom. Further, this study picturized challenges, upsides, and downsides of using the approach and method in the bilingual classroom which needs further balance of two language acquisitions. This study implicates principles of second language teaching and learning and most importantly bilingual teaching resources are required to improve the effectiveness of bilingual teaching.
The Debate on Avant-Garde and Modernism—With Russian Futurism and Symbolism as an Example
Authors: Wang Zonghu 
Published: July 2022

Abstract
The relation between avant-garde and modernism has always been an issue in dispute, partly because the hypothetical nature of the terms makes them hard to cover the all-encompassing artistic reality, and partly because discussion of their relation is always in a macroscopic perspective, which makes it difficult to produce detailed and concrete research results. This paper compares Russian futurism and symbolism to analyze the similarities and differences between avant-garde and modernism in terms of their ontological, artistic, and linguistic views in creation. It has, to some extent, obtained a relatively clear answer to the relation between avant-garde and modernism.
On unitary equivalence to a self-adjoint or doubly–positive Hankel operator
Authors: Martin Robert T.W. 
Published: July 2022

Abstract
Let A be a bounded, injective and self-adjoint linear operator on a complex separable Hilbert space. We prove that there is a pure isometry, V, so that AV > 0 and A is Hankel with respect to V, i.e. V
*
A = AV, if and only if A is not invertible. The isometry V can be chosen to be isomorphic to N ∈ ℕ ∪ {+∞} copies of the unilateral shift if A has spectral multiplicity at most N. We further show that the set of all isometries, V, so that A is Hankel with respect to V, are in bijection with the set of all closed, symmetric restrictions of A
−1.
Challenges in the determination of the macroscopic degree of cleanliness determined by ultrasonic immersion testing of (ultra-clean) gear steels
Authors: Fuchs D. , Tobie T. , Stahl K. 
Published: July 2022

Abstract
Power density demands for gearboxes are steadily increasing. Higher gear steel qualities can help to meet these demands. Steel manufacturer, as well as customers, usually examine the quality of gear steel batches. For this purpose, ultrasonic immersion testing is a fast and non-destructive evaluation method for the determination of the macroscopic degree of cleanliness. The evaluation follows certain standards and the common influence factors are usually well known. However, the state of knowledge shows that there are still many open questions. Some of these open questions can lead to differences between the results of different laboratories. In the framework of a research project, the macroscopic degree of cleanliness of ultra-clean gear steels had to be determined. However, first results showed significant differences between the results of the laboratories. For this reason, an interlaboratory test was initiated. The same samples were used for the characterizations at the different laboratories. The aim of the investigation was to determine the influencing factors that led to the different results. Based on the interlaboratory test, countermeasures should be defined to ensure a reliable determination of the macroscopic degree of cleanliness of (ultra-clean) gear steels and to ensure comparable results from different laboratories in the future.
The Soundscape of Alola
Authors: Gunn Milly 
Published: July 2022

This article explores how Pokémon Sun and Pokémon Moon use Hawaiian musical tropes and nondiegetic signifiers throughout the games, helping to “situate the player in the game.” This identification relies on a combination of player cultural literacy and game musical literacy to contextualize the Pokémon region of Alola. The soundscape of the game is made up of the underscore, incorporating traditional instruments from the steel guitar to Ka'eke'eke drums, alongside diegetic sounds to evoke and situate gameplay in a culture and geography most likely foreign to the player. The player’s ability to contextualize and situate themselves in this region relies on a combination of their cultural and game musical literacy.
This investigation will also address the consumption of Hawaiian culture both within Japan and in the West, and the portrayal of its traditional music and performance within not only the Pokémon franchise but other AAA game titles that have been enjoyed globally. The use of these musical tropes and nondiegetic signifiers simultaneously grounds the player in the region of Alola, whilst constructing a sense of “otherness” in a Hawaiian soundscape designed by composers who are observing and enjoying the culture as tourists and visitors.
The soundscape developed for Alola takes inspiration from traditional Hawaiian culture and music, but it ultimately diverges from these musical traditions and thereby produces a sonic environment unique to the fictional region. Consequently, players develop a literacy built through a return to the sounds traditionally associated with the Pokémon game franchise with a new addition of Hawaiian musical tropes to create a region that serves as something of a pastiche of Hawai'i, packaged to be culturally palatable and consumable to nonnative audiences.
Penerimaan Teknologi Virtual Reality Untuk Virtual Tourism di Indonesia
Authors: Khaqiqi Shafiq , Alfansi Lizar 
Published: July 2022

ABSTRACTOver the last few years, the technology of tourism has grown significantly. Technology that is still relatively new in tourism is Virtual Reality (VR). VR technology is a solution, especially during the current pandemic, where many tourist attractions are closed. The novelty of the experience offered by VR is still relatively new and its acceptance in tourism still needs to be explored further. This study aims to determine the determinants of the acceptance of VR technology for virtual tourism by examining the effect of seven independent variables on one dependent variable Behavioral Intention to Use VR in Tourism. This study uses a quantitative approach using primary data obtained through the distribution of online questionnaires with 246 respondents filling out this questionnaire. The data processing technique of this research uses the Statistical Package for Social Science (SPSS) software. The analytical method used by the researcher is multiple linear regression analysis. The results showed that all variables used in this study had a significant effect on adoption intentions. Six variables had a positive effect and one variable had a negative effect. ABSTRAKSelama beberapa tahun terakhir, teknologi pariwisata telah berkembang secara signifikan. Teknologi yang masih tergolong baru dalam dunia pariwisata adalah Virtual Reality (VR). Teknologi Virtual Reality (VR) menjadi solusi, terutama di masa pandemi saat ini, dimana banyak tempat wisata ditutup. Kebaruan pengalaman yang ditawarkan oleh VR masih relatif baru dan penerimaannya dalam pariwisata masih perlu dieksplorasi lebih lanjut. Penelitian ini bertujuan untuk mengetahui determinan penerimaan teknologi VR untuk pariwisata virtual dengan menguji pengaruh tujuh variabel independen (Perceived Enjoyment, Perceived Immersion, Technology Anxiety, Social Influence, dan Sensation Seeking.) terhadap satu variabel dependen Behavioral Intention to Use VR in Tourism. Penelitian ini menggunakan pendekatan kuantitatif dengan menggunakan data primer yang diperoleh melalui penyebaran kuesioner online dengan metode snowball sampling. 246 responden dinyatakan memenuhi syarat sebagai sample. Responden terdiri dari masyarakat umum dengan umur lebih dari 15 tahun yang mengetahui tentang Teknologi Virtual Reality. Teknik pengolahan data penelitian ini menggunakan software Statistical Package for Social Science (SPSS) versi 24.0. Metode analisis yang digunakan adalah regresi linier berganda. Hasil penelitian menunjukkan bahwa semua variabel yang digunakan dalam penelitian ini berpengaruh signifikan terhadap niat adopsi, dengan enam variabel berpengaruh positif dan satu variabel berpengaruh negatif.
Cardiotoxicity of anticancer drugs and radiotherapy in patients with hematologic malignancies and solid tumors
Authors: Kogoniya L. M. , Rusanov M. O. , Shikina V. E. 
Published: July 2022

Cardioncology has emerged as a new field at the intersection of cardiology and oncology. Despite the fact that improving efficiency of antitumor treatment increased the survival of oncological hematological patients, the long-term cardiovascular consequences of this treatment have become more clinically significant.Despite the effectiveness of modern methods of treatment, some drugs, such as Bcr-Abl kinase inhibitors, anthracyclines, HER2/Erbb2 inhibitors, vascular endothelial growth factor inhibitors, fluoropyrimidines, as well as radiation therapy can have a pronounced effect on the cardiovascular system. These toxic effects lead to cardiac arrhythmia, heart failure, vascular toxicity and even death. It is important for hematologists, oncologists and cardiologists to understand the basic diagnostic and treatment strategies that should be used in the event of toxicity of this kind. At a time when, due to the developed cardiotoxicity, antitumor therapy should be discontinued, in some cases, it is possible to consider continuing treatment with caution and careful monitoring.
Toxicity assessment of acute lymphoblastic leukemia treatment protocol ALL IC-BFM 2002
Authors: Valiev T. T. , Shervashidze M. A. , Belysheva T. S. 
Published: July 2022

Background. Treatment results of acute lymphoblastic leukemia in children on protocol, developed by one of the leading research study group BFM (Berlin-Frankfurt-Munster) are impressive - longstanding overall survival rate comprise 93.4 %. The basis of success is a differential approach based on prognostic factors. In some local issues BFM protocols receive criticism because of high toxicity, but trying to find results of complex protocol toxicity assessment by modern scales in local literature, it was absent.Aim. To study a toxicity of acute lymphoblastic leukemia treatment by ALL IC-BFM 2002 protocol.Materials and methods. 119 patients with primary diagnosed acute lymphoblastic leukemia were enrolled the study. All the patients were treated by ALL IC-BFM 2002 protocol. Toxicity assessment was performed by the scale of National Cancer Institute (NCI) USA, 2nd version.Results. The most often variants of toxicity during treatment according to the ALL IC-BFM 2002 protocol were myelo-suppression, infections and hepatotoxicity of I-IV degrees of severity. Clinically significant toxicity (grade IV) was myelosuppression and necessity for transfusions in 76.8-100 % (depending on prognostic risk group and as such protocol arm). Nephro- and hepatotoxicity described on high-dosed methotrexate (2000 mg/m2 or 5000 mg/m2) were I-II grade in 89.5 % patients. Stomatitis grade I-II was in 93.7 % patients of standard and intermediate risk groups, but in the most (90 %) patients from high risk group it was higher - grade III-IV. Mortality on protocol ALL IC-BFM 2002 caused by infection complications was 1.6 %. It should be noted, that supportive care, prescribed in ALL IC-BFM 2002 protocol help to prevent and correct severe toxicity effectively.Conclusion. The toxicity profile of ALL IC-BFM 2002 protocol, analyzed by frequency of toxicity grade III-IV with whole supportive care approaches, is acceptable. The noted variants of toxicity were fully resolved without irreversible consequences for the patients.
Neutrosophic Beta Omega Closed Sets in Neutrosophic Topological Spaces
Authors: A. Anusuya, A. Nagarajan S. Pious Missier, 
Published: July 2022

We introduce and examine several applications of neutrosophic beta omega closed sets namely , , , , in this study. We also introduce the concept of neutrosophic betaomega continuous mapping in neutrosophic topology. Furthermore, we study the relation between the neutrosophic betaomega continuous mapping with the already existing neutrosophic continuous mapping. In addition, we discuss the properties of neutrosophic betaomega continuous mapping.