bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of pre- and post-weaning supplementation on performance, nutritional, and metabolic characteristics in Nellore heifers under grazing
Authors: de Paula Camila , Rennó Luciana Navajas , Ferreira Matheus Fellipe de Lana , Silva Ághata Elins Moreira da , Moreira Samira Silveira , Assis Gutierrez José de Freitas , Detmann Edenio , Valadares Filho Sebastião de Campos , Fonseca Paulino Mário , Santos Giancarlo Magalhães dos 
Published: July 2022

Context Supplementation during the pre- and post-weaning periods is essential to improve the development of beef heifers in tropical pastures. Especially during the dry period, performance of heifers is limited due to low forage yield and poor nutritional value. Aim Evaluate the effect of supplementation during pre- and post-weaning periods on performance, nutritional, and metabolic characteristics in Nellore heifers under grazing. Methods Fifty-four Nellore heifers were randomly divided between the following four supplementation plans, with two replicates: NN, not supplemented in the pre- and post-weaning dry period; NS, not supplemented in the pre-weaning period and supplemented in the post-weaning dry period; SN, supplemented in the pre-weaning period and not supplemented in the post-weaning dry period; and SS, supplemented in the pre- and post-weaning dry periods; with 14, 13, 13 and 14 calves in each treatment respectively. In the post-weaning dry-to-rainy transition period, all heifers were supplemented. Key results Supplementation increased (P < 0.05) the intake of dry matter and crude protein on Day 56 (pre-weaning phase) and Day 168 (post-weaning dry period). Heifers supplemented during the pre-weaning phase had a higher final body weight (fBW) and average daily gain (ADG) on Day 112 (P < 0.05). Heifers NS and SS had higher fBW and ADG on Day 224 (P < 0.05). On Day 280, fBW were higher (P < 0.05) for heifers NS and SS. Insulin-like growth factor 1 was higher for heifers supplemented in the pre-weaning period on Day 112, and higher for NS and SS heifers on Day 224 (P < 0.05). Albumin concentrations were higher (P < 0.05) for heifers NS and SS on Day 280. Supplementation had no effect on either corpus luteum presence or concentration of progesterone (P > 0.05). Conclusions Supplementation during either pre- or post-weaning phases improved multiple performance, nutritional, and metabolic characteristics. The results due to supplementation post-weaning were independent of supplementation pre-weaning. However, supplementation did not result in an improved response to the puberty induction protocol used in this experiment. Implications For replacement heifers, it is important to maintain high weight gains at all stages of growth.
Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity
Authors: Ma Lijuan , Yang Fan , Wu Xiang , Mao Chunyou , Guo Lulu , Miao Tianshu , Zang Shao-Kun , Jiang Xiaoyu , Shen Dan-Dan , Wei Tianhui , Zhou Hengxing , Wei Qin , Li Shiyang , Shu Qiang , Feng Shiqing , Jiang Changtao , Chu Bo , Du Lutao , Sun Jin-Peng , Yu Xiao , Zhang Yan , Zhang Pengju 
Published: July 2022

The G protein–coupled bile acid receptor (GPBAR) is the membrane receptor for bile acids and a driving force of the liver–bile acid–microbiota–organ axis to regulate metabolism and other pathophysiological processes. Although GPBAR is an important therapeutic target for a spectrum of metabolic and neurodegenerative diseases, its activation has also been found to be linked to carcinogenesis, leading to potential side effects. Here, via functional screening, we found that two specific GPBAR agonists, R399 and INT-777, demonstrated strikingly different regulatory effects on the growth and apoptosis of non–small cell lung cancer (NSCLC) cells both in vitro and in vivo. Further mechanistic investigation showed that R399-induced GPBAR activation displayed an obvious bias for β-arrestin 1 signaling, thus promoting YAP signaling activation to stimulate cell proliferation. Conversely, INT-777 preferentially activated GPBAR-Gs signaling, thus inactivating YAP to inhibit cell proliferation and induce apoptosis. Phosphorylation of GPBAR by GRK2 at S310/S321/S323/S324 sites contributed to R399-induced GPBAR–β-arrestin 1 association. The cryoelectron microscopy (cryo-EM) structure of the R399-bound GPBAR-Gs complex enabled us to identify key interaction residues and pivotal conformational changes in GPBAR responsible for the arrestin signaling bias and cancer cell proliferation. In summary, we demonstrate that different agonists can regulate distinct functions of cell growth and apoptosis through biased GPBAR signaling and control of YAP activity in a NSCLC cell model. The delineated mechanism and structural basis may facilitate the rational design of GPBAR-targeting drugs with both metabolic and anticancer benefits.
Corpus RLD
Authors: Manteca Ángel Alonso-Cortés , Ayuga Juan Manuel Díaz , Fernández–Pampillón Cesteros Ana María 
Published: July 2022

Abstracta
Este artículo explica el corpus RLD, una recopilación de sentencias dictadas por jueces del Tribunal Supremo y del Tribunal Constitucional que han optado por el uso de diccionarios y la gramática del español como autoridad lingüística en la redacción de dichas sentencias judiciales. Las cuatro fases seguidas para la construcción del corpus –(i) diseño, (ii) implementación, (iii) revisión y (iv) publicación– se explican detalladamente. El objetivo del corpus, que incluye 1940 sentencias emitidas entre los años 2012 y 2018, es proporcionar una muestra de datos representativos y empíricamente satisfactorios del empleo de los diccionarios y la gramática como autoridad lingüística en la jurisprudencia española. Este corpus viene a cubrir un vacío en los estudios de lengua y derecho: por una parte, la ausencia de grandes corpus de textos jurídicos compartidos, disponibles para cualquier investigador o grupo de investigación interesado; y, por otra, la necesidad de analizar empíricamente el uso del diccionario y la gramática en las sentencias del Tribunal Supremo y del Tribunal Constitucional.
Phase field crystal simulation of gap healing at nanoscale
Authors: Li Yi-xuan , Gao Ying-Jun , Yi Xiao-Ai , Deng Qian-Qian , Kun Liao , Huang Zong-Ji , Luo Zhi-Rong 
Published: July 2022

Abstract
The phase field crystal method is used to simulate the healing process of the central gap of three-dimensional bcc crystal material under compressive strain at the atomic level. It is found that during the healing process of the central gap, the gap protrudes at both ends of it, leading to dislocation nucleation and vacancy formation. Through the mechanism of dislocation nucleation and dislocation emission, the thickness of gap is reduced layer by layer, and finally the connection and closure of the lattice atoms on up and down surface of the gap are achieved, and the surface healing of the central gap is realized. According to the sharpening and passivation mechanism of the lattice atomic planes at both ends of the gap, the elliptic shape gap is approximated to calculate and analyze the influence of the change of stress intensity factor during the gap healing, and the critical condition of the gap dislocation emission is determined.
Surface induced melting of long Al nanowires: phase field model and simulations for pressure loading and without it
Authors: Javanbakht Mahdi , Eskandari Shekoofeh Salehi , Silani Mohammad 
Published: July 2022

Abstract
In this paper, melting of long Al nanowires is studied using a phase field model in which deviatoric transformation strain described by a kinetic equation produces a promoting driving force for both melting and solidification and consequently, a lower melting temperature is resolved. The coupled system of the Ginzburg–Landau equation for solidification/melting transformation, the kinetic equation for the deviatoric transformation strain and elasticity equations are solved using the COMSOL finite element code to obtain the evolution of melt solution. A deviatoric strain kinetic coefficient is used which results in the same pressure as that calculated with the Laplace equation in a solid neglecting elastic stresses. The surface and bulk melting temperatures are calculated for different nanowire diameters without mechanical loading which shows a good agreement with existing MD and analytical results. For radii R > 5 nm, a complete surface solid-melt interface is created which propagates to the center. For smaller radii, premelting occurs everywhere starting from the surface and the nanowire melts without creating the interface. The melting rate shows an inverse power relationship with radius for R < 15 nm. For melting under pressure, the model with constant bulk modulus results in an unphysical parabolic variation versus pressure in contrast to the almost linear increase of the melting temperature versus pressure from known MD simulations. Such drawback is resolved by considering the pressure dependence of the bulk modulus through the Murnaghan’s equation due to which an almost linear increase of the melting temperature versus pressure is obtained. Also, a reduction of the interface width and a significant increase of the melting rate versus pressure are found. The presented model and results allow for a better understanding of the premelting and melting of different metallic nanowires with various loading conditions and structural defects.
Computability of topological pressure on compact shift spaces beyond finite type*
Authors: Burr Michael , Das Suddhasattwa , Wolf Christian , Yang Yun 
Published: July 2022

Abstract
We investigate the computability (in the sense of computable analysis) of the topological pressure P
top(ϕ) on compact shift spaces X for continuous potentials

ϕ
:
X
→
R

. This question has recently been studied for subshifts of finite type (SFTs) and their factors (sofic shifts). We develop a framework to address the computability of the topological pressure on general shift spaces and apply this framework to coded shifts. In particular, we prove the computability of the topological pressure for all continuous potentials on S-gap shifts, generalised gap shifts, and particular beta-shifts. We also construct shift spaces which, depending on the potential, exhibit computability and non-computability of the topological pressure. We further prove that the generalised pressure function (X, ϕ) ↦ P
top(X, ϕ|
X
) is not computable for a large set of shift spaces X and potentials ϕ. In particular, the entropy map X ↦ h
top(X) is computable at a shift space X if and only if X has zero topological entropy. Along the way of developing these computability results, we derive several ergodic-theoretical properties of coded shifts which are of independent interest beyond the realm of computability.
Orbital stability of a sum of solitons and breathers of the modified Korteweg–de Vries equation
Authors: Semenov Alexander 
Published: July 2022

AbstractIn this article, we prove that a sum of solitons and breathers of the modified Korteweg–de Vries equation (mKdV) is orbitally stable. The orbital stability is shown inH2. More precisely, we will show that if a solution of mKdV is close enough to a sum of solitons and breathers with distinct velocities att= 0 in theH2sense, then it stays close to this sum of solitons and breathers for any timet⩾ 0 in theH2sense, up to space translations for solitons or space and phase translations for breathers, provided the condition that the considered solitons and breathers are sufficiently decoupled from each other and that the velocities of the considered breathers are all positive, except possibly one. The constants that appear in this stability result do not depend on translation parameters. From this, we deduce the orbital stability of any multi-breather of mKdV, provided the condition that the velocities of the considered breathers are all positive, except possibly one (the condition about the decoupling of the considered solitons and breathers between each other is not required in this setting). The constants that appear in this stability result depend on translation parameters of the considered solitons and breathers.
Partial regularity for an exponential PDE in crystal surface models
Authors: Xu Xiangsheng 
Published: July 2022

Abstract
We study regularity properties of weak solutions to the boundary value problem for the equation −Δρ + au = f in a bounded domain

Ω
⊂

R

N

, where

ρ
=

e

−
div

|
∇
u

|

p
−
2

∇
u
+

β

0

|
∇
u

|

−
1

∇
u

. This problem is derived from the mathematical modelling of crystal surfaces. It is known that the exponential term can be a measure-valued function. In this paper we obtain a partial regularity result, which asserts that there exists an open subset Ω0 ⊂ Ω such that |Ω\Ω0| = 0 and the exponential term is locally bounded in Ω0. Furthermore, if x
0 ∈ Ω\Ω0, then ρ vanishes of N + 2 − ɛ order at x
0 for each ɛ ∈ (0, 2).
Nonlinear dynamic buckling and vibration of thermally post-buckled temperature-dependent FG porous nanobeams based on the nonlocal theory
Authors: Salari E , Ashoori A R , Sadough Vanini S A , Akbarzadeh A H 
Published: July 2022

Abstract
In this paper, nonlinear dynamic snap-through buckling and vibration behavior of the thermally post-buckled functionally graded (FG) porous nanobeams subjected to static and sudden mechanical loads are investigated utilizing the nonlocal elasticity theory. The physical properties of the nanobeam are considered to be functions of temperature based on the Touloukian model. In addition, to describe the FG porous materials, two different patterns of porosity distribution are adopted using trigonometric functions through the thickness of the nanobeam. The equations of motion in conjunction with the von-Kármán nonlinear assumption are established in the framework of Hamilton’s principle. By employing the Chebyshev-Ritz procedure, the nonlinear equations are discretized for three types of edge supports. Following that, the cylindrical arc-length technique is employed to assess the vibrational responses of the post-buckled nanobeam during static snap-through buckling. To evaluate the nonlinear dynamic buckling of the graded nanobeam under a sudden dynamic load, the Newmark time integration scheme together with the Newton-Raphson iterative method are utilized. Next, by means of the Budiansky-Roth criterion and the phase-plane approach, the dynamic snap-through loads are identified. After validating the developed mathematical model, a comprehensive investigation is carried out to determine the role of various physical and geometrical parameters on the dynamic snap-through buckling and vibration characteristics of the post-buckled FG nanobeams.
Study of the structural, electronic, mechanical, electro-thermal and optical properties of double perovskite structures Cs2SbAgX6, (X = I, Br, or Cl)
Authors: Jafar Aqel Mashot , Khalaph Kawther A , Al Husseini Hussein B 
Published: July 2022

Abstract
In the double perovskites structures, Cs2SbAgX6, X is I, Br, or Cl, the structural, electronic, thermodynamic, thermoelectric and optical, properties have been investigated by using the density functional theory (DFT) correction method. The XRD structural study exhibits that the double perovskite structures are stable in the cubic phase structures. Elastic parameters reveal all structures to be very hard and ductile in nature. The energy band profiles display indirect band-gap of semiconductor behavior for the structures Cs2SbAgX6; X is Cl or Br, while exhibiting metallic behavior of the structure Cs2SbAgI6. The thermoelectric transport properties were verified in the temperature range (5–1000) K, which includes electrical conductivity, thermal conductivity, Seebeck coefficients, and the figure of merit, ZT, for Cs2SbAgX6 structures. These structures exhibit high thermal conductivity with good Seebeck coefficients at room temperature. The semiconducting structure, Cs2SbAgBr6, has appropriate band gaps and best Seebeck coefficients; therefore, it has the best values of ZT reached 0.000 16 at 1000 K, which means the suitable structure for employment in thermoelectric and spintronic devices applications. The optical properties of these structures exhibit that the absorption effective region at the Visible-Ultraviolet region, therefore these materials are suitable in the applications of solar cells and optoelectronic devices.
CW and Q-switched operations of a Tm3+:YAP laser at 1892–1994 nm In-band fiber-laser pumped at 1670 nm
Authors: Antipov O L , Dobrynin A A , Getmanovskiy Yu A , Sharkov V V , Shestakova I A , Balabanov S S , Larin S V 
Published: July 2022

Abstract
Tm3+:YAP lasers in-band fiber-laser pumped at 1670 nm with a linear or L-shaped cavity were studied in CW, actively and passively Q-switched regimes. High-efficiency CW and repetitively-pulsed operations were registered at three spectral regions: 1987–1994 nm, 1935–1941 nm and 1892–1897 nm. The transition between these three spectral regions was achieved by controlling the pump power and the output mirror in a laser cavity. The highest CW output power that was achieved without degrading the beam quality was 12.2 W at the 52% slope efficiency with respect to the incident pump. Acousto-optically Q-switched operation with the average power of 9.8 W at the 20 kHz pulse repetition rate (PRR) and 6 W at 3 kHz PRR was achieved, the pulse energy was scaled up to 2.7 mJ at 0.5 kHz PRR. The passive Q-switch operation at 1935–1938 nm was obtained using a Cr2+:ZnSe saturable absorber; the pulse energy reached 150 µJ at the 20 kHz PRR
Nuclear data libraries for IFMIF-DONES neutronic calculations
Authors: Mendoza E. , Cano-Ott D. , Ibarra A. , Mota F. , Podadera I. , Qiu Y. , Simakov S.P. 
Published: July 2022

Abstract
International Fusion Materials Irradiation Facility-DEMO Oriented NEutron Source (IFMIF-DONES) is an installation aimed to irradiate with a high neutron flux materials relevant for the construction of the DEMOnstration fusion power plant (DEMO), in order to study the damage due to irradiation. Neutrons are generated using a 40 MeV and 125 mA deuteron beam impinging on a thick liquid lithium target. With these characteristics, damage due to irradiation comparable to that in the first wall of a fusion power reactor is achieved. In this paper we investigate the differences in the neutronic calculations of the IFMIF-DONES design when using different nuclear data libraries. We first studied the differences in neutron production due to Li(d, xn) reactions between different models and evaluations, comparing the different results with experimental data. Additionally, we tested the performance of the MCNP6.2 and Geant4 Monte Carlo codes when using deuteron incident data libraries. Then, we performed neutronic calculations of the IFMIF-DONES design using the most reliable Li(d, xn) neutron production models available, which are the FZK-2005 and JENDL/DEU-2020 evaluations according to the results obtained in the first part of the study. Thus, the differences in these evaluations are propagated to different neutronic calculation results: neutron flux, primary displacement damage, gas production, and heating in the materials to be irradiated. Finally, we also carried out these same neutronic calculations while using different nuclear data libraries for the neutron transport.
Symmetry-driven network reconstruction through pseudobalanced coloring optimization
Authors: Leifer Ian , Phillips David , Sorrentino Francesco , Makse Hernán A 
Published: July 2022

Abstract
Symmetries found through automorphisms or graph fibrations provide important insights in network analysis. Symmetries identify clusters of robust synchronization in the network which improves the understanding of the functionality of complex biological systems. Network symmetries can be determined by finding a balanced coloring of the graph, which is a node partition in which each cluster of nodes receives the same information (color) from the rest of the graph. In recent work we saw that biological networks such as gene regulatory networks, metabolic networks and neural networks in organisms ranging from bacteria to yeast and humans are rich in fibration symmetries related to the graph balanced coloring. Networks based on real systems, however, are built on experimental data which are inherently incomplete, due to missing links, collection errors, and natural variations within specimens of the same biological species. Therefore, it is fair to assume that some of the existing symmetries were not detected in our analysis. For that reason, a method to find pseudosymmetries and repair networks based on those symmetries is important when analyzing real world networks. In this paper we introduce the pseudobalanced coloring (PBCIP) problem, and provide an integer programming formulation which (a) calculates a PBCIP of the graph taking into account the missing data, and (b) optimally repairs the graph with the minimal number of added/removed edges to maximize the symmetry of the graph. We apply our formulation to the C. elegans connectome to find pseudocoloring and the optimal graph repair. Our solution compares well with a manually curated ground-truth C. elegans graph as well as solutions generated by other methods of missing link prediction. Furthermore, we provide an extension of the algorithm using Bender’s decomposition that allows our formulation to be applied to larger networks.
Design optimization of engine mounting system for a modular electric vehicle platform with different powertrain characteristics
Authors: Hazra Sandip , Janardhan Reddy K 
Published: July 2022

Abstract
In recent days, there is much focus on the modularity of the platform to reduce the cost and improve the system-level design efficiency. In this paper, a study has been done for various non-linear input torque (different powertrain) and optimization with a modular powertrain mounting system where only stiffness is varied to achieve the optimization goal. Here, the optimization goals are maximization of kinetic energy distribution to improve the decoupling rate and minimization of powertrain CoG movement under torque. HEEDS and MATLAB optimization tools are used for analysis. First, three different powertrains are considered individually for optimization. Then, all three powertrains for a particular location on the modular platform are optimized with different mount stiffness. Different mount stiffnesses are chosen in such a way that the stiffness can be achieved only by hardness adjustment or minimum design modification without any change in complete mount design. Proposed results show that a properly chosen mounting system can address the platform modularity quite quickly.
Integrated artificial intelligence and life cycle assessment to predict environmental and economic impacts for natural gas hybrid electric vehicle with multi-dimension
Authors: Miao Yang , Qiu Zaihui , Zhang Meng , He Baofeng , Zhang Xiaolu , Li Miao 
Published: July 2022

Abstract
The automotive industry plays very significant role in Chinese industry. but higher energy consumption and higher pollution accompanying with the vehicle’s industry chain as well. natural gas for vehicles has the characteristics of cleanness, economy and reliability. Therefore, the hybrid vehicle with both advantages of natural gas and electricity has great potential. However, it is unclear that the promotion of natural gas / electric hybrid vehicles (NGEHV) could really achieve energy saving and emission reduction. In this paper, consider all stages vehicle production, transportation, use, maintenance and scrap recovery, the possession is decomposed into three aspects: resource attributes, energy attributes and environmental attributes. An composition analysis method of NGEHV is constructed. A life cycle assessment(LCA), in the view of Cradle-to-Grave, of environmental impact for natural gas / electric hybrid vehicles is established. Based on BP neural network, prediction information of traditional vehicles and NGEHV on various environmental factors and costs are obtained. It could provide scientific basis for the sustainable advancement and decision-making for government.