bluuebunny/crossref_metadata_2025_split huggingface dataset:
The feasibility and effects of a pharmacological treatment algorithm for cancer patients with terminal dyspnea: A multicenter cohort study
Authors: Mori Masanori , Yamaguchi Takashi , Suzuki Kozue , Matsuda Yoshinobu , Matsunuma Ryo , Watanabe Hiroaki , Ikari Tomoo , Matsumoto Yoshihisa , Imai Kengo , Yokomichi Naosuke , Miwa Satoru , Yamauchi Toshihiro , Okamoto Soichiro , Inoue Satoshi , Inoue Akira , Morita Tatsuya , Satomi Eriko ,   the Japanese Dyspnea Relief Investigators
Published: October 2022

AbstractBackgroundHow clinicians treat patients with terminal dyspnea widely varies, which could hamper quality care. We visualized comprehensive pharmacological treatment delivered by palliative care physicians.AimTo examine adherence to a comprehensive pharmacological treatment algorithm for patients with terminal dyspnea, and to explore its outcomes during 48 h.DesignA multicenter cohort study at five sites (February 2020 to June 2021).Setting/ParticipantsWe prospectively enrolled consecutive patients with advanced cancer, Eastern Cooperative Oncology Group performance status 3–4, and moderate/severe dyspnea. Participating palliative care physicians initiated algorithm‐based treatment. The primary outcome was the proportion of adherence to the treatment algorithm over 24 h (predefined goal, 70%). We evaluated the adherence, goal achievement, and dyspnea level with a numerical rating scale (NRS), as well as adverse events over 48 h.ResultsAll 108 patients received algorithm‐based pharmacological treatment. Among 96 and 87 patients who were alive at 24 and 48 h, respectively, 96 (100%; 95% confidence interval [CI] = 96%–100%) and 82 (94%; 95%CI = 87%–98%) continued to receive the algorithm treatment, respectively, and 66 (69%; 95%CI = 59%–77%) and 64 (74%; 95%CI = 63%–82%) achieved the treatment goals, respectively. Using a complete case analysis with paired t‐tests, mean dyspnea NRS scores significantly reduced from 7.3 (standard error, 0.2) at the baseline to 4.9 (0.3) at 24 h (n = 72; p < 0.001), and 7.2 (0.3) at the baseline to 4.6 (0.4) at 48 h (n = 55; p < 0.001). Most adverse events were mild to moderate.ConclusionsThe comprehensive pharmacological treatment algorithm was feasible, and the study data supports its preliminary efficacy and safety. The use of this algorithm may help clinicians improve care for patients with terminal dyspnea.
Development of venetoclax performance using its new derivatives on BCL‐2 protein inhibition
Authors: Najafi Vahideh , Yoosefian Mehdi , Hassani Zahra 
Published: October 2022

AbstractCancer cells are resistant to apoptosis and this is one of the most obvious symptoms of cancer in humans. One of the most exciting strategies for treating cancer is to design regulators that increase cell death and stop cell growth. Members of the BCL‐2 family of proteins play an important role in the regulation of apoptosis. In this study, an attempt was made to improve the performance of one of the anticancer drugs by designing new analogs of venetoclax (VNT). For this purpose, molecular docking studies were performed to determine the best binding state of VNT and its newly designed derivatives at the protein‐binding site to estimate the binding energy. The best analog in terms of free energy was VNT‐12 with the lowest energy (−12.15 kcal/mol). Finally, to investigate the inhibitory effect of the compounds on BCL‐2 protein, molecular dynamics simulation was used, and by performing the relevant analyses during the simulation, it was observed that the newly designed ligand had better performance in inhibiting BCL‐2 protein compared to VNT.
Regulation of radiation‐induced liver damage by modulation of SIRT‐1 activity: In vivo rat model
Authors: El‐Sheikh Marwa M. , Abdel‐Naby Doaa H. , El‐Hazek Rania M. , El‐Ghazaly Mona A. 
Published: October 2022

AbstractSilent information regulator 1 (SIRT‐1), a nicotinamide adenine dinucleotide‐dependent deacetylase, was found to regulate cell apoptosis, inflammation, and oxidative stress response in living organisms. Therefore, the role of SIRT‐1 in regulating forkhead box O/poly ADP‐ribose polymerase‐1 (FOXO‐1/PARP‐1) signaling could provide the necessary validation for developing new pharmacological targets for the promotion or inhibition of SIRT‐1 activity toward radiation sensitivity. In the present study, the SIRT‐1 signaling pathway is being investigated to study the possible modulatory effect of resveratrol (RSV, SIRT‐1 activator) versus nicotinamide (NAM, SIRT‐1 inhibitor) in case of liver damage induced by whole‐body gamma irradiation. Rats were exposed to 6 Gy gamma radiation after being pretreated with either RSV (10 mg/kg/day) or NAM (100 mg/kg/day) for 5 days, and subsequent examining hepatic morphological changes and apoptotic markers were assessed. The expression of SIRT‐1, FOXO‐1, and cleaved PARP‐1 in the liver was analyzed. RSV improved radiation‐induced apoptosis, mitochondrial dysfunction, and inflammation signified by low expression of caspase‐3, lactate dehydrogenase, complex‐I activity, myeloperoxidase, and total nitric oxide content. RSV increased the expression of SIRT‐1, whereas cleaved PARP‐1 and FOXO‐1 were suppressed. These protective effects were suppressed by inhibition of SIRT‐1 activity using NAM. These findings suggest that RSV can attenuate radiation‐induced hepatic injury by reducing apoptosis and inflammation via SIRT‐1 activity modulation.
Fluvoxamine prompts the antitumor immune effect via inhibiting the PD‐L1 expression on mice‐burdened colon tumor
Authors: Wei Pengkun , Jia Huijie , Li Ruipeng , Zhang Congli , Guo Shuoshuo , Wei Sujiao , Sun Ke , Cheng Sichang , Cui Tongquan , Huang Juan , Guo Sheng , Guo Jing , Yang Zishan , Zhong Jiateng , Lu Chengbiao , Feng Zhiwei , Zhao Tiesuo 
Published: October 2022

AbstractA colon tumor, one of the digestive tract malignant tumors, is harmful to human health. A potential new treatment still deserves attention. The development of a new drug needs more resources, including time and expense. Therefore, the old drug with new targets has become a current research hotspot. Fluvoxamine, as an antidepressant, could play an effect on inhibiting 5‐hydroxytryptamine reuptake. In the present research, the antitumor effects and possible mechanisms of fluvoxamine are validated. The results showed that fluvoxamine significantly suppressed the migration and proliferation of tumor cells, and increased the apoptosis in vitro. Additionally, fluvoxamine significantly delays tumor development, and prompts the apoptosis in tumor tissues of mice‐burdened colon tumors in vivo. The tumor suppression might be related with that fluvoxamine inhibits the expression of phosphorylated signal transducer and activator of transcription 3, matrix metalloproteinase 2, and cleaved‐caspase 3. Importantly, fluvoxamine significantly reduces the expression level of programmed cell death ligand 1. This could be a possible reason that treatment with fluvoxamine drives the infiltration of T lymphocytes and M1‐type macrophages in tumor tissues. Taken together, this research suggests that fluvoxamine might be a promising drug to treat colon cancer by inhibiting the proliferation and migration, inducing apoptosis, and even increasing the immune response of antitumor.
Multiple asymptomatic papules following breast cancer treatment
Authors: Chaima Kouki , Khadija Sellami , Emna Bahloul , Emna Mnif , Soumaya Graja , Nadine Kammoun , Naourez Gouiaa , Tahya Boudawara , Hamida Turki 
Published: October 2022

AbstractAcquired lymphangiectasia (AL) represents superficial lymphatic dilatation caused by different processes. It is a consequence of lymphatic damage by an external cause; leading to obstruction of local lymphatic drainage.1 We report a case of AL of the breast in a 45‐year‐old woman mimicking warts.
Chitosan‐Silica as a Cheap Carrier and Green Soft Ligand for Improved Ru‐catalyzed Hydroformylation
Authors: Escobar‐Bedia Francisco Javier , Martin‐Diaconescu Vlad , Simonelli Laura , Sabater Maria J. , Concepción Patricia 
Published: October 2022

AbstractDodecacarbonyltriruthenium Ru3(CO)12 has been immobilized onto a biopolymer (chitosan) supported on SiO2 (Ch@SiO2) to give Ru−Ch@SiO2. Ch@SiO2 behaves as a soft, recoverable and bulky ligand allowing the stabilization of released Ru active species and preventing its irreversible reduction to Ru0. Under these conditions very high activity (TOF= 1086 h−1; TON=2749) and regioselectivity (n:iso=92 : 8) are obtained, surpassing that of the homogeneous Ru3(CO)12 counterpart.Spectroscopic studies have shown that Ru3(CO)12 transforms into a mononuclear Run+ (n=2,3) di o try carbonyl species by interacting with the amido/amino groups of the biopolymer, being released into the reaction media whilst stabilized by the chitosan functional groups.The herein 0.5 Ru‐Ch@SiO2 catalyst can operate be operated under a semi‐continuous mode for at least 14 h without deactivation, representing providing a starting point in the search for a green catalyst with definitive industrial application in hydroformylations. In particular in the search for a heterogeneous catalyst away from the use of phosphines and their known drawbacks (i. e. tedious synthesis, facile oxidation of phosphor center, ..) as well as expensive Rh as active site.
Water‐Triggered Chemical Transformation of Perovskite Nanocrystals
Authors: Das Avik , Debnath Tushar 
Published: October 2022

AbstractRecently emerged lead‐halide perovskite nanocrystals (PNCs) are promising optoelectronic material due to their easy solution processability, wide range of color tunability, as well as very high photoluminescence quantum yield. Despite their significant success in lab‐scale optoelectronic applications, the long‐term stability becomes the main issue, hindering them towards commercialization. The highly ionic nature of such lead‐halide structure makes them extremely unstable in water and air. But a very few groups have taken the advantage of such nature of the crystal structure for water‐triggered chemical transformation towards shape, composition, and morphology controlled stable and bright PNCs, which are otherwise difficult to obtain by typical direct approach. Furthermore, using polymer as an encapsulating layer for the PNCs, water‐soluble stable PNCs have been prepared. In this review, the recent progress on the water–hexane interface chemistry towards chemical transformation to produce several PNCs is described. Such method not only ensure to yield several shape‐controlled perovskites nanocrystals, but also formation of perovskites in aqueous phase that show promising application towards bio‐imaging.
Cobalt Cyclopentadienyl‐Phosphine Dinitrogen Complexes
Authors: Wang Gao‐Xiang , Yan Xuechao , Yin Jianhao , Yin Zhu‐Bao , Wei Junnian , Xi Zhenfeng 
Published: October 2022

AbstractBy applying the potassium salts of cyclopentadienyl‐phosphine ligands LK to CoCl2, the corresponding cobalt chlorides (1, LCoIICl) were prepared. By reducing complexes 1 with KHBEt3 under a N2 atmosphere, bridging end‐on complexes, LCoI−N2−CoIL (2 a and 2 b), were successfully obtained. 15N2‐labeled [15N2]‐2 a was prepared under 15N2/14N2 exchange in THF solution. LCoI−N2−CoIL complex 2 a could react with P4 molecules to release N2 and generate a Co−P4−Co moiety 4. Further reduction of complex 2 b led to cleavage of a P−C bond in the cyclopentadienyl‐phosphine ligand to provide novel μ‐PCy2‐bridged Co0−N2 complex 5. DFT calculations confirmed the experimental observations.
Stimulus‐Responsive Lanthanide MOF Materials Encapsulated with Viologen Derivatives: Characterization, Photophysical Properties and Sensing on Nitrophenols
Authors: Li Hui‐Shu , Xing Shang‐Hua , Xiao Yao , Wang Chen , Guan Qing‐Lin , Bai Feng‐Ying , Xing Yong‐Heng , Xu Fen 
Published: October 2022

AbstractViologens (1,1’‐disubstituted 4,4’‐bipyridyls) possessing electron‐deficient properties and redox activity are a class of suitable chromophores to assemble metal–organic hybrid photochromic materials. Thus, viologen‐functionalized metal–organic frameworks (MOFs) have attracted much attention for their photochromic properties; however, the syntheses of lanthanide‐viologen hybrid crystalline photochromic materials still face many challenges. For example, the structures and properties of the final products are difficult to predict and are limited by molecular configurations. In this work, host‐guest composite‐material Ln‐NH2BDC‐pbpy MOFs were constructed by encapsulating viologen derivative pbpyCl2. The pbpy2+ moieties are uniformly embed by their π‐π conjugation in the pores of the 3D structure by electrostatic interactions. Due to the encapsulation of the chromophore pbpy2+ moieties, Ln‐NH2BDC‐pbpy MOFs have reversible photochromic properties: they can change color after irradiation and can return to the original color after being protected from light or heating. Interestingly, the fluorescence intensity decreases with illumination time and recovers in the dark. As a result, Ln‐NH2BDC‐pbpy MOFs show both photochromic and photomodulated fluorescence. Based on the outstanding fluorescence performance of the Ln‐NH2BDC‐pbpy MOFs, they also show a wonderful effect for detecting nitrophenols, especially TNP.
Coordination of Pnictogenylboranes Towards Tl(I) Salts and a Tl‐ Mediated P−P Coupling
Authors: Szlosek Robert , Ackermann Matthias T. , Marquardt Christian , Seidl Michael , Timoshkin Alexey Y. , Scheer Manfred 
Published: October 2022

AbstractThe coordination chemistry of only Lewis‐base (LB)‐stabilized pnictogenylboranes EH2BH2⋅NMe3 (E=P, As) towards Tl(I) salts has been studied. The reaction of Tl[BArCl] (BArCl=[B(3,5‐C6H3Cl2)4]−) with the corresponding pnictogenylborane results in the formation of [Tl(EH2BH2⋅NMe3)][BArCl] (1 a: E=P; 1 b: E=As). Whereas the Tl ion in 1 a/b is monocoordinated, the exchange of the weakly coordinating anion (WCA) in the Tl(I) salt leads to the formation of a trigonal pyramidal coordination mode at the Tl atom by coordination of three equivalents of EH2BH2 ⋅ NMe3 in [Tl(EH2BH2 ⋅ NMe3)3][WCA] (2 a: E=P, WCA=TEFCl; 2 b: E=As, WCA=TEF) (TEF=[Al{OC(CF3)3}4]−, TEFCl=[Al{(OC(CF3)2(CCl3)}4]−). Furthermore, by using two equivalents of PH2BH2⋅NMe3, a Tl(I)‐mediated P−P coupling takes place in CH2Cl2 as solvent resulting in [Me3N⋅BH2PH2PHBH2⋅NMe3][WCA] (WCA=TEF, 3 a; BArCl, 3 b; TEFCl, 3 c). In contrast, for the arsenic derivatives 1 b and 2 b, no coupling reaction is observed. The underlying chemical processes are elucidated by quantum chemical computations.
Overclocking Nitronyl Nitroxide Gold Derivatives in Cross‐Coupling Reactions
Authors: Zayakin Igor , Tretyakov Evgeny , Akyeva Anna , Syroeshkin Mikhail , Burykina Julia , Dmitrenok Andrey , Korlyukov Alexander , Nasyrova Darina , Bagryanskaya Irina , Stass Dmitri , Ananikov Valentine 
Published: October 2022

AbstractNitronyl nitroxides are functional building blocks in cutting‐edge research fields, such as the design of molecular magnets, the development of redox and photoswitchable molecular systems and the creation of redox‐active components for organic and hybrid batteries. The key importance of the nitronyl nitroxide function is to translate molecular‐level‐optimized structures into nano‐scale devices and new technologies. In spite of great importance, efficient and versatile synthetic approaches to these compounds still represent a challenge. Particularly, methods for the direct introduction of a nitronyl nitroxide moiety into aromatic systems possess many limitations. Here, we report gold derivatives of nitronyl nitroxide that can enter Pd(0)‐catalysed cross‐coupling reactions with various aryl bromides, affording the corresponding functionalized nitronyl nitroxides. Based on the high thermal stability and enhanced reactivity in catalytic transformation, a new reagent is suggested for the synthesis of radical systems via a universal cross‐coupling approach.
A novel modified long short term memory architecture for automatic liver disease prediction from patient records
Authors: Antony Asir Daniel V. , Ramaraj Ravi 
Published: October 2022

SummaryThe liver is the second largest organ in the human body after the skin and liver disease mainly impacts the liver's functionality by properly separating the nutrients and waste into the digestive system and also causes scarring (cirrhosis) as time passes. The scarring over time affects the healthy liver tissue and also affects its proper functioning and if left untreated for a prolonged period it can also result in severe complications such as liver failure or liver cancer. The patients can be prevented from the severe complications if the disease is detected at an earlier stage and the existing research for liver disease prediction mainly encouraged the usage of intelligent machine learning‐based techniques. However, these techniques have several complexities such as low accuracy, overfitting, higher training time, poor feature extraction capabilities and so on. To overcome these problems, we present modified long short term emory (MLSTM) architecture for chronic liver disease prediction. The proposed methodology has three stages: information enhancement, feature extraction, and classification. The modified generative adversarial network uses an autoencoder system for sample augmentation which helps to enrich the diversity present in both the normal and abnormal classes. The outlier information is eliminated via the criminal search algorithm which captures the differences and correlation associated with multiple samples. The fast independent component analysis algorithm and enhanced whale optimization algorithm are used for feature extraction. This step mainly identifies the crucial features for liver disease prediction and leaves out the irrelevant and duplicate features thus enhancing the convergence, computational time, and prediction accuracy. The MLSTM architecture is used to classify the samples present in the liver disease datasets into normal and abnormal (liver disease) classes. The proposed methodology offers improved performance in terms of accuracy, recall, means square error, and F‐measure. The results show that the proposed methodology will be efficient for doctors to diagnose liver disease in the earlier stage.
A real‐time privacy‐preserving scheme based on grouping queries for continuous location‐based services
Authors: Liu Haoyu , Zhang Shiwen , Li Mengling , Liang Wei , Arthur Sandor Voundi Koe 
Published: October 2022

SummaryWith the advancement of global positioning systems and communication technologies, location‐based services (LBS) have become widely used. However, user location privacy is vulnerable during service exchange, and location‐related queries may result in serious privacy disclosure issues. In this article, considering that attackers may make use of auxiliary information to track a mobile user, we propose a real‐time privacy‐preserving scheme based on the grouping of queries in continuous LBS. In this scheme, we first design the probability density functions to select virtual locations. Then, we group these virtual locations and the query location of the user into several queries. Simultaneously, we send these grouping queries to the LBS server. Following the steps outlined above, grouping queries can be used to conceal the true query. Moreover, the results of security analyses and performance evaluations show that the proposed scheme is effective and secure.
Photoactive Covalent Organic Frameworks for Catalyzing Organic Reactions
Authors: Yang Liting , Wang Jialin , Zhao Kun , Fang Zhe , Qiao Huijie , Zhai Lipeng , Mi Liwei 
Published: October 2022

AbstractBecause of their large surface areas, long‐range order, π‐π stacking interactions and hierarchically integrated building blocks, covalent organic frameworks (COFs) have attracted increasing attention. Recently, COFs have been regarded as promising heterogeneous photocatalysts, owing to their remarkable light‐harvesting and energy transition capabilities. The research progress of COFs in photocatalytic organic synthesis is summarized, such as preparation of imines through the oxidation of amines, selective oxidation of sulfides, oxidative hydroxylation of arylboronic acids, C−H bond activation, cyclization, asymmetric organic synthesis and so on. Finally, a perspective of the present challenges of photoactive COFs in organic transformations is given.
Fostering Innovation and Global Competitiveness in the 2023 Farm Bill
Authors: Owen Rachel K. 
Published: October 2022

AbstractWith the 2018 farm bill set to expire next year, stakeholder groups—like CCAs and members of the American Society of Agronomy (ASA), Crop Science Society of America (CSSA), and Soil Science Society of America (SSSA)—are working to develop their recommendations to put forward to Congress. During this time, it is critical that our Societies engage in the discussion and make sure that Congress is aware of the effects that farm bill programs have on the scientific community. To do this, a Farm Bill Task Force, made up of CCAs and members from all three Societies, has been established to assist the Science Policy Office staff in developing our policy and research recommendations.
Biodiversity conservation adaptation to climate change: Protecting the actors or the stage
Authors: Zhu Gengping , Giam Xingli , Armsworth Paul R. , Cho Seong‐Hoon , Papeş Monica 
Published: October 2022

AbstractTo be able to protect biodiversity in coming decades, conservation strategies need to consider what sites will be important for species not just today but also in the future. Different methods have been proposed to identify places that will be important for species in the future. Two of the most frequently used methods, ecological niche modeling and climate resilience, have distinct aims. The former focuses on identifying the suitable environmental conditions for species, thus protecting the “actor,” namely, the species, whereas the latter seeks to safeguard the “stage,” or the landscape in which species occur. We used the two methods to identify climate refugia for 258 forest vertebrates under short‐ and long‐term climatic changes in a biodiversity hotspot, the Appalachian ecoregion of the United States. We also evaluated the spatial congruence of the two approaches for a possible conservation application, that of protecting 30% of the Appalachian region, in line with recent national and international policy recommendations. We detected weak positive correlations between resilience scores and baseline vertebrate richness, estimated with ecological niche models for historical (baseline) climatic conditions. The correlations were stronger for amphibians and mammals than for birds and reptiles. Under climate change scenarios, the correlations between estimated vertebrate richness and resilience were also weakly positive; a positive correlation was detected only for amphibians. Locations with estimated future gain of suitable climatic conditions for vertebrates showed low correlation with resilience. Overall, our results indicate that climate resilience and ecological niche modeling approaches capture different characteristics of projected distributional changes of Appalachian vertebrates. A climate resilience (the stage) approach could be more effective in safeguarding species with low dispersal abilities, whereas an ecological niche modeling (the actor) approach could be more suitable for species with long‐distance dispersal capacity because they may be more broadly impacted by climate and less sensitive to geophysical features captured by a climate resilience approach.