bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and characteristics of factitious hypoglycaemia in non‐diabetic patients in a department of endocrinology
Authors: Oueslati Ibtissem , Terzi Amani , Yazidi Meriem , Kamoun Elyes , Chihaoui Melika 
Published: September 2022

AbstractIntroductionFactitious hypoglycaemia is defined as the surreptitious use of insulin or oral hypoglycaemic agents to deliberately induce self‐harm. It represents a challenging diagnosis and misdiagnosis is associated with significant morbidity and mortality.The aim of this study was to assess the prevalence and the associated factors of factitious hypoglycaemia in non‐diabetic patients.MethodsThis was a single‐centre, retrospective study including 70 non‐diabetic patients who were admitted for the investigation of hypoglycaemia. All patients fulfilled the Whipple triad. Epidemiological parameters, medical history, clinical and paraclinical data and the aetiology of hypoglycaemia were collected from medical records.ResultsThe diagnosis of factitious hypoglycaemia was held in 11 patients (9 women and 2 men) corresponding to a prevalence of 16%. It was secondary to intentional insulin use in six patients and the ingestion of glibenclamide in five patients. The median age of the patients was 28 years (interquartile range: 21–43). Two patients with factitious hypoglycaemia had a personal history of psychiatric disorders. The other causes of hypoglycaemia were adrenal insufficiency (34%), prediabetes (24%), insulinoma (6%), iatrogenic hypoglycaemia (10%), criminal hypoglycaemia (1%) and alcohol intoxication (2%). Age ≤ 35 years (Odds Ratio = 5.6, p = .017), family history of diabetes mellitus (Odds Ratio = 1.29, p = .015), attention disorders during hypoglycaemia (Odds Ratio = 12.5, p = .017) and fasting glucose level <0.7 g/L (Odds Ratio = 5.75, p = .017) were positively associated with factitious hypoglycaemia.ConclusionFactors significantly associated with factitious hypoglycaemia were young age, family history of diabetes and a low fasting glucose level.
Return to work in patients with head and neck cancer: Systematic review and meta‐analysis
Authors: Yu Justin , Smith Justin , Marwah Ravi , Edkins Oskar 
Published: September 2022

AbstractBackgroundThe aim of this review was to determine the prevalence of return to work (RTW) amongst head and neck cancer (HNC) survivors and to determine its impact on quality of life (QoL).MethodsA literature search was conducted in PubMed, Scopus, Embase and CINAHL in March 2021. Articles were included if they reported the number of patients with HNC receiving definitive treatment who were working at the time of diagnosis and returned to work.ResultsThere were 21 articles deemed eligible for inclusion. Meta‐analysis suggested that 67% of patients with HNC who were employed at diagnosis RTW (95% CI 62%–73%, I2 = 97.53%). Patients who RTW were demonstrated to have lower levels of anxiety and depressive symptoms on the Hospital Anxiety and Depression Scale.ConclusionsReturn to work is an important clinical outcome which must be considered in the survivorship care of patients with HNC.
IL-1β/NF-κB signaling inhibits IGF-1 production via let-7f-5p in dendritic epidermal T cells
Authors: Li Yashu , Wang Juan , Wang Yangping , He Weifeng , Zhang Yixin , Liu Yan 
Published: September 2022

AbstractDendritic epidermal T cells (DETCs) are the main source of insulin-like growth factor-1 (IGF-1) in epidermal tissue, which promote re-epithelialization and wound healing. In refractory wounds, IL-1β has been shown to activate NF-κB and suppress IGF-1 expression in DETCs. Nevertheless, the underlying mechanisms remain unclear. In this study, chromatin immunoprecipitation analysis revealed that IL-1β did not inhibit NF-κB binding to IGF-1 promoter, indicating that IL-1β/NF-κB may suppress IGF-1 expression by alternative mechanisms. MiRNAs negatively regulate gene expression predominantly by base pairing to the 3′ untranslation region (UTR) of target mRNAs. Let-7f-5p, miR-1a-3p, and miR-98-5p have been identified as IGF-1-specific miRNAs that can bind directly to the 3′UTR of IGF-1 mRNA and dysregulate IGF-1 mRNA and protein levels. In IL-1β-treated epidermis around wounds or DETCs in vitro, NF-κB promoted the expression of let-7f-5p, and IGF-1 expression was impeded via NF-κB/let-7f-5p pathway. As pre-let-7f-5p, let-7f-1 is located in the 3′UTR of LOC118568094, and let-7f-2 is located in the intron of HUWE1. We discovered that NF-κB p65 bound to the promoters of LOC118568094 and HUWE1 to accelerate let-7f-5p expression, but NF-κB p65 did not affect the methylation levels of LOC118568094 and HUWE1 CpG islands. Injections of Let-7f-5p antagomir into IL-1β-treated and ischemic wound margins restored IGF-1 secretion in DETCs and promoted wound healing. In conclusion, we demonstrated that NF-κB signaling pathway activated by IL-1β could increase let-7f-5p expression to inhibit IGF-1 production in DETCs and delay wound healing. And let-7f-5p antagomir utilized in wound margin could effectively promote refractory wound healing.
Impact of anticoagulation therapy on the cognitive decline and dementia in patients with non‐valvular atrial fibrillation (cognitive decline and dementia in patients with non‐valvular atrial fibrillation [CAF] trial)
Authors: Bunch Thomas Jared , May Heidi , Cutler Michael , Woller Scott C. , Jacobs Victoria , Stevens Scott M. , Carlquist John , Knowlton Kirk U. , Muhlestein Joseph B. , Steinberg Benjamin A. , Anderson Jeffrey L. 
Published: September 2022

AbstractBackgroundAtrial fibrillation (AF) is associated with a risk for cognitive impairment and dementia, which is more pronounced in patients with a history of clinical stroke. Anticoagulation use and efficacy impact long‐term risk of dementia in AF patients in observational trials.MethodsThe cognitive decline and dementia in patients with non‐valvular atrial fibrillation (CAF) Trial was a randomized, prospective, open‐label vanguard clinical study with blinded endpoint assessment involving patients with moderate‐ to high‐risk (CHADS2 or CHA2DS2‐Vasc scores of ≥2) non‐valvular AF assigned to dabigatran etexilate or warfarin. The primary endpoint was incident dementia or moderate cognitive decline at 24 months.ResultsA total of 101 patients were enrolled [mean age:73.7 ± 6.0 years, male: 54(53.5%)]. Prior stroke and stroke risk factors were similar between groups. Average INR over the study was 2.41 ± 0.68 in the warfarin group. No patient experienced a stroke or developed dementia. Mini‐Mental Status Evaluation, Hachinski Ischemic scale, cognitive subscale of the Alzheimer's Disease Assessment Scale, Disability Assessment for Dementia, Quality of Life Improvement as assessed by Minnesota Living with Heart Failure Scale and the Anti‐Clot Treatment Scale Quality of Life Survey scores did not vary at baseline or change over 2 years. Biomarker analysis indicated a similar efficacy of anticoagulation strategies.ConclusionUse of dabigatran and well‐managed warfarin therapy were associated with similar risks of stroke, cognitive decline, and dementia at 2 years, suggestive that either strategy is acceptable. The results of this Vanguard study did not support the pursuit of a larger formally powered study.
Effects of lateral instability on ankle coupled motions in vivo using 3D fluoroscopy
Authors: Lin Shang‐His , Hung Li‐Wei , Kuo Mei‐Ying , Lin Cheng‐Chung , Lu Hsin‐Yi , Weng Pei‐Ling , Fan Chia‐Ling , Kuo Chien‐Chung , Lu Tung‐Wu 
Published: September 2022

AbstractLateral ankle instability (LAI) compromises the normal kinematics of the ankle, affecting activities of daily living. In vitro kinematics of ankles with LAI during single‐plane motions are available, but the active control stability of these motions remains unclear. The current study measured the 3D ankle kinematics during unresisted single‐plane motion tests using a bi‐plane fluoroscope with a CT model‐based 2D/3D registration method in 12 patients with LAI and 14 healthy peers. The coupling of the kinematic components at the talocrural and subtalar joints was quantified by the path difference between the forward and return paths of the coupled motion. Significantly increased path differences were found in the subtalar dorsiflexion/plantarflexion and inversion/eversion components during internal/external rotation tests (p < 0.05). During inversion/eversion, significantly reduced tibiocalcaneal ranges of motion and the path differences in the talocrural and subtalar dorsiflexion/plantarflexion components were noted (p < 0.05). The current results suggest that chronic LAI had compromised control stability at the subtalar joint during internal/external rotation tests and a conservative motion control strategy with significantly reduced ranges of motion to maintain good control of out‐of‐plane motion components in response to direct challenges of the anterior talofibular ligament during inversion/eversion tests. The current results also suggest that, compared to kinematic patterns of individual components, the path difference of the coupled motion may serve as a better measure of the motion control stability of the ankle in differentiating LAI from healthy controls.
Absolute thermometry using hyperpolarized 129Xe free‐induction decay and spin‐echo chemical‐shift imaging in rats
Authors: Kern Agilo L. , Gutberlet Marcel , Rumpel Regina , Bruesch Inga , Hohlfeld Jens M. , Wacker Frank , Hensen Bennet 
Published: September 2022

PurposeTo implement and test variants of chemical shift imaging (CSI) acquiring both free induction decays (FIDs) showing all dissolved‐phase compartments and spin echoes for specifically assessing Xe in lipids in order to perform precise lipid‐dissolved Xe MR thermometry in a rat model of general hypothermia.MethodsImaging was performed at 2.89 T. of Xe in lipids was determined in one rat by fitting exponentials to decaying signals of global spin‐echo spectra. Four rats (conventional CSI) and six rats (turbo spectroscopic imaging) were scanned at three time points with core body temperature 37/34/37C. Lorentzian functions were fit to spectra from regions of interest to determine the water‐referenced chemical shift of lipid‐dissolved Xe in the abdomen. Absolute Xe‐derived temperature was compared to values from a rectal probe.ResultsGlobal of Xe in lipids was determined as . Friedman tests showed significant changes of chemical shift with time for both sequence variants and both FID and spin‐echo acquisitions. Mean and SD of Xe and rectal probe temperature differences were found to be (FID) and (spin echo) for conventional CSI as well as (FID) and (spin echo) for turbo spectroscopic imaging.ConclusionXe MRI using conventional CSI and turbo spectroscopic imaging of lipid‐dissolved Xe enables precise temperature measurements in the rat's abdomen using both FID and spin‐echo acquisitions with acquisition of spin echoes enabling most precise temperature measurements.
Optimized ultrahigh field parallel transmission workflow using rapid presaturated TurboFLASH transmit field mapping with a three‐dimensional centric single‐shot readout
Authors: Bosch Dario , Bause Jonas , Geldschläger Ole , Scheffler Klaus 
Published: September 2022

PurposeTo evaluate the usage of three‐dimensional (3D) presaturated TurboFLASH (satTFL) for and mapping on single channel and parallel transmission (pTx) systems.Methods maps recorded with 3D satTFL were compared to maps from three other 3D mapping sequences in an agar phantom. Furthermore, individual‐channel maps of 18 human subjects were recorded with 3D satTFL using interferometry. A neural network was trained for masking of the maps.ResultsOut of the sequences compared satTFL was the only one with a mapping range exceeding well over 90°. In regions with lower flip angles there was high correspondence between satTFL and AFI. DREAM and double angle method also showed high qualitative similarity, however the magnitude differed from the other two measurements. The individual‐channel maps were successfully used for pTx pulse calculation in a separate study.Conclusion3D satTFL can record high‐quality maps with a high dynamic range in a short time. Correspondence with AFI maps is high, while measurement duration is reduced drastically.
Clinical analysis of patients who dropout in oral appliance therapy in obstructive sleep apnea
Authors: Hiraga Chiho Kondo , Komatsu Masumi , Ito Yasutaka , Sato Kazumichi , Yoshida Yoshifumi , Nakajima Tsuneya , Iimura Jiro , Matsuura Nobuyuki , Nomura Takeshi 
Published: September 2022

AbstractAimThe purpose of this study was to characterize patients who received oral appliance (OA) therapy for obstructive sleep apnea (OSA) and to investigate the factors linked to patient dropout from OA therapy.MethodsThis study included 132 patients with OSA. The patients were categorized into an OA user group or a dropout group. Clinical parameters and craniofacial features were compared.ResultsFifty‐seven patients (43.2%) dropped out of OA therapy. The most common reasons for stopping OA therapy, as reported by patients, were unknown (51%), ineffectiveness (16%), strong discomfort not related to the temporomandibular joint TMJ (e.g., tooth or gum pain; 14%), pain in the TMJ (TMJ; 9%), nasal symptoms (4%), excessive salivation (2%), and other reasons (5%). Body mass index (BMI) and the presence or absence of OSA‐related complications (e.g., cardiovascular disease, cerebrovascular disease, and diabetes) were determined by univariate analysis. Age, BMI, facial axis (Fx), and the presence of OSA‐related complications were determined by multivariate logistic analyses to be risk factors for dropping out of OA therapy.ConclusionsThis study found that more patients than anticipated had discontinued OA treatment for various reasons.
Polyvinyl alcohol‐modified graphene oxide as a support for bimetallic Pt–Pd electrocatalysts to enhance the efficiency of formic acid oxidation
Authors: Saipanya Surin , Fang Li , Themsirimongkon Suwaphid , Maturost Suphitsara , Pongpichayakul Natthapong , Promsawan Napapha , Waenkaew Paralee 
Published: September 2022

AbstractThe aim of this research was to study the efficiency of polyvinyl alcohol (PVA)‐modified graphene oxide (GO) as a supporting material for catalysts that oxidize formic acid. The active metal catalysts (e.g., Pt and Pd) were electrodeposited on PVA/GO surfaces. The morphologies of the prepared catalysts were characterized by scanning electron microscopy and transmission electron microscopy, while their chemical compositions were identified by X‐ray diffraction and X‐ray photoelectron spectroscopy. The results show that compared with the other catalysts on GO, the prepared active PtPd alloy catalyst nanoparticles with 11.49–20.73 nm sizes were well dispersed on the PVA/GO surfaces. Electrochemical results indicate that the activities of the catalysts with PVA provided a higher current density than that of the catalysts without PVA. The bimetallic 3Pt3Pd/PVA/GO catalyst showed the greatest catalytic activity, stability, and CO oxidation when compared to those of other catalysts. The electronic, morphological, and structural properties promote the mass‐charge transfer through the interaction. These results indicate that the PVA‐modified GO provides a suitable site for active bimetallic catalyst surfaces, resulting in excellent formic acid oxidation and high CO elimination. The 3Pt3Pd/PVA/GO electrocatalyst is promising for enhancing formic acid oxidation.
The development of the Negative Bias in Prospection Scale: A novel assessment of dysfunctional prospection in depression
Authors: Yang Zhuo‐ya , Zheng Ying‐can , Yang Xiao , Wang Ya‐ting , Feng Zheng‐zhi 
Published: September 2022

Abstract“Prospection” refers to the ability to mentally simulate one's future episodes. Negative bias in prospection, which includes both reduced positivity and enhanced negativity, is considered to be closely related to the development and maintenance of depression. However, there is a relative paucity of measures that adequately assess negative bias in prospection in depressed people. The current study developed and initially validated the Negative Bias in Prospection Scale (NBPS) using a nonclinical sample (n = 959). The validity and reliability of the NBPS were investigated in several ways. Results suggested the 14 NBPS items loaded onto three factors, namely the “Increased negativity,” the “Reduced positivity,” and the “Overgeneralization.” The NBPS demonstrated decent internal consistency and test–retest reliability. Further, the NBPS was strongly associated with severity of depressive symptoms. Moreover, the NBPS was correlated in a theoretically meaningful way with other measures of future‐oriented cognitions or negative biases. In conclusion, the NBPS has promising preliminary psychometric properties. It will be an efficient tool for exploring dysfunctional prospection in depression and provides a novel measure for mechanism of change in prospection‐based interventions.
Influencing the influencers: Regulating the morality of online conduct in Indonesia
Authors: Mahy Petra , Winarnita Monika , Herriman Nicholas 
Published: September 2022

AbstractIndonesia boasts a lively influencer scene. These influencers promote various products and messages, including political messages, to their followers for commercial gain, and have been particularly active during the coronavirus disease 2019 (COVID‐19) pandemic. Influencers in Indonesia are potentially subject to state regulation, particularly via the controversial Electronic Transactions and Information Law (ITE Law) which criminalizes digital communications that “breach morality,” defame the good name of another, or spread misleading information resulting in consumer losses. In addition, influencers face a risk of community‐led regulation, via an online backlash, should they transgress perceived moral boundaries. In this article, we present and analyze a series of case studies where influencer behavior has attracted regulatory responses. These cases illustrate the interactions among regulatory actors and also where and how the lines for acceptable influencer moral standards of behavior are being drawn.
Broadcasting anti‐media populism in the Philippines: YouTube influencers, networked political brokerage, and implications for governance
Authors: Soriano Cheryll Ruth R. , Gaw Marie Fatima 
Published: September 2022

AbstractThis article interrogates platform governance and accountability amid the growing role of influencers in constructing political discourses, and particularly, in the intermediation of anti‐media ideological frames through their embeddedness in networked assemblages. We deploy the concept of “networked political brokerage” to examine the sociotechnical relations among influencers, the platform, and its users, and how this dynamic assemblage engages in the intermediation of anti‐media populism. The study draws from a critical examination of the network and discursive tactics deployed by Filipino YouTube influencers who advance partisan political commentary and deceptive narratives to delegitimize mainstream media institutions through issue network analysis concerning the franchise denial and eventual shutdown of the Philippines' oldest media network, ABS‐CBN. We problematize how influencers engage platform affordances and cultures of use to enable, amplify, and fortify the brokering of their political agenda within a larger network of political actors, while eliding accountability. Through the mutually affirming relationship of content creators and the platform, networked hyperpoliticized contents gain visibility and galvanize anti‐media rhetoric. Ultimately, the article raises concerns on the social consequences of networked political brokerage and offers a framework for how governance and policy discussions can treat the functioning of such networked political influence.
Spiritual well‐being, distress and quality of life in Hispanic women diagnosed with cancer undergoing treatment with chemotherapy
Authors: Barata Anna , Hoogland Aasha I. , Small Brent J. , Acevedo Karina I. , Antoni Michael H. , Gonzalez Brian D. , Jacobsen Paul B. , Lechner Suzanne C. , Tyson Dinorah Martinez , Meade Cathy D. , Rodriguez Yvelise , Salsman John M. , Sherman Allen C. , Sutton Steven K. , Jim Heather S. L. 
Published: September 2022

AbstractObjectivePrevious studies have examined whether spiritual well‐being is associated with cancer outcomes, but minority populations are under‐represented. This study examines associations of baseline spiritual well‐being and change in spiritual well‐being with change in distress and quality of life, and explores potential factors associated with changes in spiritual well‐being among Hispanic women undergoing chemotherapy.MethodsParticipants completed measures examining spiritual well‐being, distress, and quality of life prior to beginning chemotherapy and at weeks 7 and 13. Participants' acculturation and sociodemographic data were collected prior to treatment. Mixed models were used to examine the association of baseline spiritual well‐being and change in spiritual well‐being during treatment with change in distress and quality of life, and to explore whether sociodemographic factors, acculturation and clinical variables were associated with change in spiritual well‐being.ResultsA total of 242 participants provided data. Greater baseline spiritual well‐being was associated with less concurrent distress and better quality of life (p < 0.001), as well as with greater emotional and functional well‐being over time (p values < 0.01). Increases in spiritual well‐being were associated with improved social well‐being during treatment, whereas decreases in spiritual well‐being were associated with worsened social well‐being (p < 0.01). Married participants reported greater spiritual well‐being at baseline relative to non‐married participants (p < 0.001).ConclusionsGreater spiritual well‐being is associated with less concurrent distress and better quality of life, as well as with greater emotional, functional, and social well‐being over time among Hispanic women undergoing chemotherapy. Future work could include developing culturally targeted spiritual interventions to improve survivors' well‐being.
SH‐PRO extract alleviates benign prostatic hyperplasia via ROS‐mediated activation of PARP/caspase 3 and inhibition of FOXO3a/AR/PSA signaling in vitro and in vivo
Authors: Park Ji Eon , Shin Woo‐Cheol , Lee Hyo‐Jung , Yoon Dahye , Sim Deok Yong , Ahn Chi‐Hoon , Park Su‐Yeon , Shim Bum Sang , Park So Jung , Kim Kyung Seok , Park Geum Duck , Kim Sung‐Hoon , Lee Dae Young 
Published: September 2022

AbstractTo target benign prostatic hyperplasia (BPH) as a common urinary disease in old men, in the current study, the antiproliferative and apoptotic mechanism of SH‐PRO, a mixture of Angelica gigas and Astragalus membranaceus (2:1), was evaluated in BPH‐1 cells and rats with testosterone‐induced BPH. Herein, SH‐PRO significantly reduced the viability of BPH‐1 cells and dihydrotestosterone (DHT)‐treated RWPE‐1 cells. Also, SH‐PRO increased the sub‐G1 population in BPH‐1 cells and consistently attenuated the expression of pro‐PARP, pro‐caspase 3, Bcl2, FOXO3a, androgen receptor (AR), and prostate‐specific antigen (PSA) in BPH‐1 cells and DHT‐treated RWPE‐1 cells. Of note, SH‐PRO generated reactive oxygen species (ROS) in BPH‐1 cells, while ROS inhibitor N‐acetyl‐l‐cysteine (NAC) disturbed the ability of SH‐PRO to reduce the expression of pro‐PARP, FOXO3a, catalase, SOD, and increase sub‐G1 population in BPH‐1 cells. Furthermore, oral treatment of SH‐PRO significantly abrogated the weight of the prostate in testosterone‐treated rats compared to BPH control with the reduced expression of AR, PSA, and DHT and lower plasma levels of DTH, bFGF, and EGF with no toxicity. Overall, these findings highlight the antiproliferative and apoptotic potential of SH‐PRO via ROS‐mediated activation of PARP and caspase 3 and inhibition of FOXO3a/AR/PSA signaling as a potent anti‐BPH candidate.