bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effectiveness of Atorvastatin for the Prevention of Deep Vein Thrombosis in Cancer Patients Undergoing Chemotherapy
Authors: Setiawan Budi , Budianto Widi , Sukarnowati Tri Wahyu , Rizky Daniel , Pangarsa Eko Adhi , Santosa Damai , Sudoyo Aru Wisaksono , Winarni Tri Indah , Riwanto Ignatius , Setiabudy Rahajuningsih Dharma , Suharti Catharina 
Published: October 2022

Abstract
Background: Deep vein thrombosis (DVT) is a common complication in cancer. Although thromboprophylaxis in cancer patients is recommended by the guidelines, clinicians’ use of thromboprophylaxis remains limited due to cost, bleeding complications, and reluctance to give injectable anticoagulants. Inflammation plays essential roles in the pathogenesis of cancer-associated thrombosis. Owing to its ability to decrease proinflammatory cytokines, statins have anti-inflammatory properties. Thus, statins can be possibly utilized as thromboprophylaxis therapy in cancer patients undergoing chemotherapy.
Objective: To compare the effectiveness of atorvastatin and rivaroxaban for DVT prevention in high-risk thrombosis patients with cancer undergoing chemotherapy.
Methods: Double-blind, randomized controlled trial involving cancer patients with high-risk of thrombosis undergoing chemotherapy. We randomly assigned patients without deep-vein thrombosis at screening to receive atorvastatin 20 mg or rivaroxaban 10 mg daily for up to 90 days. Doppler ultrasonography was performed 90 days following chemotherapy to diagnose DVT. Average cost-effectiveness analysis was performed to analyze the cost of atorvastatin compared to rivaroxaban
Results: Of the eighty six patients who underwent randomization, primary efficacy end point was observed in 1 of 42 patients (2.3%) in the atorvastatin group and in 1 of 44 (2.2%) in the rivaroxaban group (Odds Ratio [OR], 0.953; 95% confidence interval [CI], 0.240 to 3.971; p = 1.000). There was a significant difference in the incidence of major bleeding, 2 of 42 patients (4.8%) in the atorvastatin group and 12 of 44 (27.3%) in the rivaroxaban group (OR, 0.257; 95% CI, 0.07 to 0.94; p=0.007). The average cost-effectiveness ratio of using atorvastatin was lower than that of rivaroxaban.
Conclusion:
Atorvastatin did not differ significantly from rivaroxaban in reducing the incidence of DVT, lower bleeding risk, and cost-effectiveness for thromboprophylaxis in high-risk thrombosis patients with cancer undergoing chemotherapy.
Trial Registration
ISRCTN39181.
Does DFT work for H­­2O and H2S dimers?
Authors: Sapkota Dhurba , Shrestha Pitamber , Parajuli Rajendra 
Published: October 2022

AbstractWater and hydrogen sulfide dimers have been studied with several different density functional theory (DFT) methods using a 6-311 + + G(d, p) basis set. Geometries, energies, and QTAIM parameters were computed for different functionals and the values were compared with otherab initioand experimental results available in the literature.
HTSE: Hierarchical Time-Surface Model for Temporal Knowledge Graph Embedding
Authors: Jin Langjunqing , Zhao Feng , Jin Hai 
Published: October 2022

Abstract
Representation learning based on temporal knowledge graphs (TKGs) has attracted widespread interest, and TKG embeddings express time entity and relation tokens and exhibit strong dynamics. Despite the significance of the dynamics and the persistent updates in TKGs, most studies have been devoted to static knowledge graphs. Moreover, previous temporal works ignored the semantic hierarchies observed in knowledge modelling cases, which are common in real-world applications. Inaccurate semantic expressions caused by incomplete projections might not capture complex topological structures very well. To solve this problem, a novel hierarchical time-surface embedding (HTSE) model is proposed for the representation learning of entities, relations and time. Specifically, a unified relation-oriented hierarchical space aims to distinguish relations at different semantic levels of a hierarchy , and entities can naturally reflect the corresponding hierarchy. Then, a time surface aims to enhance the temporal characteristics, and quadruples are learned through exponential mapping and tangent planes in the time surface. According to extensive experiments, HTSE can achieve remarkable performance on five benchmark datasets, outperforming baseline models for time scope prediction, temporal link prediction and hierarchical relation embedding tasks. Furthermore, the qualitative analysis is used to demonstrate the explainable strategy for hierarchical embeddings and their significance in TKGs.
Posterior Intra-articular Fixation Stabilizes Both Primary and Secondary Sacroiliac Joints: A Cadaveric Study and Comparison to Lateral Trans-articular Fixation Literature
Authors: Sayed Dawood , Amirdelfan Kasra , Hunter Corey , Raji Oluwatodimu Richard 
Published: October 2022

Abstract
Background
Posterior and lateral techniques have been described as approaches to sacroiliac joint arthrodesis. The purpose of this study was to compare the stabilizing effects of a novel posterior stabilization implant and technique to a previously published lateral approach in a cadaveric multidirectional bending model. We hypothesized that both approaches would have an equivalent stabilizing effect in flexion-extension, and that the posterior approach would exhibit better performance in lateral bending and axial rotation. We further hypothesized that unilateral and bilateral posterior fixation would stabilize both the primary and secondary joints.
Methods
Ranges of Motion (RoMs) of six cadaveric sacroiliac joints were evaluated by an optical tracking system, in a multidirectional flexibility pure moment model, between ± 7.5 Nm applied moment in flexion-extension, lateral bending, and axial rotation under intact, unilateral fixation, and bilateral fixation conditions.
Results
Intact RoMs were equivalent between both samples. Unilateral posterior intra-articular fixation reduced the RoMs of both primary and secondary joints in all loading planes (flexion-extension RoM by 45%, lateral bending RoM by 47%, and axial RoM by 33%), and bilateral fixation maintained this stabilizing effect in both joints (flexion-extension at 48%, in lateral bending at 53%, and in axial rotation at 42%). Only bilateral lateral trans-articular fixation reduced mean RoM of both primary and secondary sacroiliac joints, and only under flexion-extension loads (60%).
Conclusion
During flexion-extension, the posterior approach is equivalent to the lateral approach; while producing superior stabilization during lateral bend, and axial rotation.
Effectiveness of substantial shortening of the endotracheal tube for decreasing airway resistance and increasing tidal volume during pressure-controlled ventilation in pediatric patients: a prospective observational study
Authors: Takahashi Kazuhiro , Toyama Hiroaki , Kubo Ryosuke , Yoshida Norifumi , Ejima Yutaka , Kikuchi Kenji , Ishikawa Takuji , Yamauchi Masanori 
Published: October 2022

Abstract
Purpose: Anesthesiologists often shorten endotracheal tubes (ETTs) because the resistance of the ETT (RETT) is believed to be a major contributor to total airway resistance (Rtotal) in children intubated with ETTs of smaller inner diameter. However, the effectiveness of ETT shortening for mechanical ventilation in the clinical setting has not been reported. In this work, we performed a prospective clinical study and a laboratory experiment to assess the effectiveness of shortening a cuffed ETT for increasing tidal volume (TV) and decreasing Rtotal during constant pressure-controlled ventilation, and to estimate the RETT/Rtotal ratio in children.
Method: In anesthetized children in a constant pressure-controlled ventilation setting, TV and Rtotal were measured with a pneumotachometer before and after shortening a cuffed ETT. The pressure gradient curves for the original length, shortened length, and the slip joint alone of the ETT were measured in vitro to determine the RETT/Rtotal ratio.
Results: The clinical study included 22 children. The median ETT percent shortening was 21.7%. Median Rtotal was decreased from 26 to 24 cmH2O/L/s, and median TV was increased by 6% after ETT shortening. Additionally, approximately 40% of the pressure gradient across the ETT at its original length was generated by the slip joint. Median RETT and median RETT/Rtotal before ETT shortening were calculated as 17.7 cmH2O/L/s and 0.69, respectively.
Conclusions: The increase in TV caused by ETT shortening was small because the resistance of the slip joint was very large, limiting the effectiveness of ETT shortening.
A novel holding process for forming boxes by optimizing effect of BHF distribution
Authors: Zhang Hongsheng , Qin Siji 
Published: October 2022

Abstract
This research is aimed to adjust blank holder force (BHF) in different flange areas to eliminate wrinkles and cracks on rectangular box deep drawing product. The calculating formulae of the critical BHF in the flange area are derived by using the energy method and a wrinkle model parameter m effect on the critical BHF by is analyzed. It's shown that the critical BHF decreases with decreasing m as the same wrinkle height. Steel sheet of SPCC grade, thickness of 0.6 mm was used in the finite element simulation study. It's shown that the segmental blank holder technique is better than the conventional one. Finally, compared to the application of the single blank holder, BHF can be quite effective for preventing the occurrence of cracking and increasing the formability of deep drawing.
An overview of pharmacotherapy in the management of children diagnosed with autism spectrum disorder at a public hospital in KwaZulu-Natal, South Africa
Authors: Maniram Jennal , Oosthuizen Frasia , Karrim Saira B.S 
Published: October 2022

Abstract

Background The pharmacological management of Autism Spectrum Disorder (ASD) remains a challenge due to limited effective treatment options, the Food and Drug Administration's (FDA) approval of only two drugs, and the absence of drugs that can cure the core symptoms. In South Africa, little is known about the role of pharmacotherapy in the management of children diagnosed with ASD. This study presents an overview of prescribing patterns and provides insight into the current management practice for the core symptoms and comorbidities of ASD in children. Method A quantitative retrospective study was conducted at a public hospital in Kwa-Zulu Natal, South Africa by reviewing patient files of children diagnosed with ASD and meeting the inclusion criteria for the study. A descriptive analysis of data was done to identify treatment trends and patient therapeutic outcomes. Results A total of 181 children met the inclusion criteria of the study. Risperidone was the most frequently prescribed drug (88%) for the management of comorbidities and/or core symptoms of ASD. Attention deficit hyperactivity disorder (54%), irritability or aggression (25%), and sleep dysregulation (22%) were frequent ASD comorbidities that warranted pharmacotherapy. Drugs prescribed to manage ASD comorbidities included methylphenidate, melatonin, sodium valproate, risperidone, oxybutynin, carbamazepine, and others. Except for risperidone, there were no additional drugs that targeted the core symptoms of ASD. Non-pharmacological therapies were often used collaboratively with medication to manage ASD symptoms. The use of psychotropic drug combinations was influenced by the age and gender of a child. In 41% of patients, there were improvements in their symptoms (comorbidities and/or core symptoms) which indicated a positive response to the treatment plan. Conclusion Drugs played a prominent role in managing the comorbidities of ASD, however, pharmaco-therapeutic options for the management of ASD core symptoms are limited. As the availability and use of additional effective drugs (including vitamin, mineral, and dietary supplements) for the management of ASD increases, improved therapeutic outcomes for children with ASD in South Africa could be achievable.
Evaluation of Serum Kidney Injury Markers FABP1, NGAL, Cystatin C and the Inflammatory Cytokine IL-18 in the Detection of Acute-on-Chronic Liver Failure (ACLF) Associated Acute Kidney Injury (AKI)
Authors: Saha Rohini , Sharma Samriddhi , Mondal Antara , Sati Hem Chandra , Khan Maroof Ahmad , Mahajan Sandeep , Datta Sudip , . Shalimar , Acharya Pragyan 
Published: October 2022

Abstract
Acute-on-chronic liver failure (ACLF) is a complication of liver cirrhosis which is driven by dysfunctional innate immune activation and multiple organ failure. In ACLF, short-term mortality (28-day mortality) is ~50%. The risk of mortality in ACLF increases significantly with the occurrence of AKI. Hence, early detection and prevention of AKI is a priority for the management of ACLF patients. Here we show, that commonly used serum biomarkers of AKI i.e. FABP1, NGAL and Cystatin C, as well as a marker of inflammation IL-18, are not effective at discriminating between ACLF patients having AKI (ACLF-AKI) and ACLF patients without AKI (ACLF no-AKI). However, IL-18, which is a measure of inflammation, is able to predict mortality in ACLF patients and, Cystatin C is able to discriminate between ACLF-AKI and non-liver AKI. Our results demonstrate that the biomarkers of renal injury which might be effective in other etiologies of AKI may not be effective in early detection of ACLF associated AKI possibly suggesting a different pathomechanism of AKI in ACLF. We anticipate that this study will provide impetus to biomarker discovery studies towards early detection of AKI in ACLF patients.
PENERAPAN STRATEGI REACT BERBANTUAN GEOGEBRA DALAM MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS MATEMATIS
Authors: Sofyan Deddy , Sugandi Asep Ikin , Linda Linda , Sari Dewi Ratna , Bernard Martin 
Published: October 2022

The purpose of this research is to examine the effectiveness of applying Geogebra-assisted REACT strategy to improve students' critical thinking. The experimental method is the method chosen in this study. The population of this study were all students of the Mathematics Education Study Program, IKIP Siliwangi Bandung, while the sample was students of the Class of 2020 of the Mathematics Education Study Program of 2 classes. In this study, an instrument in the form of a description of 4 items was used to measure critical thinking. Data analysis used descriptive statistics and inferential statistics with the help of SPSS version 21. Based on the results of data processing, it was concluded that the application of the REACT strategy assisted by GeoGebra was more effective in improving critical thinking skills than conventional learning.Tujuan pada penelitian ini untuk menelaah keefektifan penerapan strategi REACT berbantuan Geogebra untuk meningkatkan berpikir kritis mahasiswa. Metode eksperimen merupakan metode yang dipilih dalam penelitian ini. Populasi penelitian ini adalah semua mahasiswa Prodi Pendidikan Matematika IKIP Siliwangi Bandung, sedangkan sampelnya adalah mahsiswa Angkatan 2020 Prodi Pendidikan Matematika sebanyak 2 kelas . Dalam penelitian ini digunakan instrumen berupa soal uraian sebanyak 4 butir soal yang digunakan dalam mengukur berpikir kritis. Analisis data yang digunakan dengan menggunakan statistik deskriptif dan statistik inferensial dengan bantuan SPSS versi 21. Berdasarkan hasil pengolahan data didapat kesimpulan bahwa penerapan strategi REACT berbantuan Geogebra lebih efektif dalam meningkatkan kemampuan berpikir kritis dibandingkan pembelajaran konvensional.
Relativistic Effects in the Rotation of Dwarf Planets and Asteroids
Authors: Pashkevich Vladimir V. , Vershkov Andrey N. 
Published: October 2022

Abstract
The effect of the geodetic rotation (which includes two relativistic effects: geodetic precession and geodetic nutation) is the most significant relativistic effect in the rotation of the celestial bodies. For the first time in this research, this relativistic effect is determined in the rotation of dwarf planets (Ceres, Pluto, and Charon) and asteroids (Pallas, Vesta, Lutetia, Europa, Ida, Eros, Davida, Gaspra, Steins, and Itokawa) in the Solar System with known values of their rotation parameters. Calculations of the values of their geodetic rotation are made by a method for studying any bodies in the Solar System with a long-term ephemeris. Values of geodetic precession and geodetic nutation for all these celestial bodies were calculated in ecliptic Euler angles relative to their proper coordinate systems and in their rotational elements relative to the fixed equator of the Earth and the vernal equinox (at the epoch J2000.0). The obtained analytical values of the geodetic rotation for the celestial bodies can be used to numerically investigate their rotation in the relativistic approximation, and also used to estimate the influence of relativistic effects on the orbital–rotational dynamics for the bodies of exoplanetary systems.
Nitrogen Removal and Sludge Reduction in Anoxic-Aerobic Sequencing Batch Reactor with Alkaline-H2O2 Disintegration
Authors: Gürtekin Engin 
Published: October 2022

Abstract
In this study, alkaline-H2O2 sludge disintegration was combined with anoxic-aerobic sequencing batch reactor (SBR). The carbon obtained by alkaline-H2O2 sludge disintegration was used in the denitrification process and sludge reduction was achieved in the SBR process. In the SBR process, a 9 % increase in nitrogen removal efficiency was achieved with the improvement in the denitrification process. A sludge reduction efficiency of 43 % was obtained in the SBR process with alkaline-H2O2 sludge disintegration. A synergistic effect was obtained in the combination of alkaline and H2O2 methods and the sludge reduction increased by 8 %. By combining sludge disintegration into the SBR process, it is possible to reduce the amount of sludge formed, which is an important environmental problem, and to provide carbon source for the denitrification process.
What Do Polygraphers–Practitioners Expect from Science?
Authors: Widacki Jan 
Published: October 2022

Abstract
The purpose of the study was to learn the opinions of polygraph examiners concerning the role and applicability of scientific research in detection of deception conducted in Universities or other scientific centres. The questionnare was distributed among participants of the 56th Annual Seminar of the American Polygraph Association (Orlando Fl. 2022). The 55 copies of the questionnare were hande out, 48 completed sheets were returned. As it could been expected, polygraph examiners are generally not interested in of detection of deception other than the ones they currently using in their practice. The new methods of detection of deception, as for example exploiting the neurophysiological level (EEG, fMRI) or methods remotely observable and registrable indicators other than those that have as yet been used in polygraph examination generally was not interested for him.
Spring phenology of oak stands in the Western Carpathians: validation of satellite metrics from MODIS using ground-based observations
Authors: Bucha Tomáš , Sitková Zuzana , Pavlendová Hana , Snopková Zora 
Published: October 2022

Abstract
The study focuses on the validation of the leaf unfolding (LU) onset of oak stands in the Western Carpathians in 2000–2021 derived from MODIS satellite data. LU onset was derived from the annual trajectories of the Normalised difference vegetation index (NDVI) fitted with a double sigmoid logistic function. The satellite metric Growing speed day (GSD) corresponding to the LU onset is represented by the first derivative of the sigmoid function. Ground-based observations from 22 phenological stations of the Slovak Hydrometeorological Institute (SHMI) were used to validate the date of GSD. The results showed a good agreement between the medians of ground- and satellite-based LU onset dates. In addition to the median, the LU onset at the 5th and 95th percentiles were compared. For both percentiles, we found differences in the onset from MODIS and SHMI. The 5th percentile of the LU onset derived from MODIS was determined later than the one from SHMI data. With the 95th percentile, it was the opposite. As a result, the range determining the duration of LU onset from MODIS was significantly shorter than from SHMI observations. The trend analyses over the period 2000–2021 revealed a shift to the earlier onset of LU ~ 0.33 day.year−1 (p = 0.13) from satellite and ~ 0.32 day.year−1 from ground-based observations (p = 0.08). The validated LU onset and trends using the median allow analysing of the oak stands response to changing environmental conditions. However, the differences at the 5th and 95th percentiles, i.e. at the beginning and the end of the LU onset duration, remained unexplained.
Syntactic variation and interactional coherence in online communication: The German conjunction “weil” in written interactions
Authors: Glaznieks Aivars 
Published: October 2022

Abstract
The current study presents an analysis of a linguistic device supporting interactional coherence in computer-mediated communication (CMC). The analysis focused on the use of the German causative conjunction weil and, more specifically, on the syntactic variation of verb-final versus verb-second word order in the weil-clause. Verb-final word order in German indicates a dependent clause, whereas verb-second word order indicates an independent clause. While only the former is accepted in written Standard German, the latter is well documented in oral communication. Relying on freely available Facebook, WhatsApp, and Wikipedia corpus data, the analysis shows that both grammatical constructions are used in written CMC. In a specific usage across discrete messages, the syntactic variation of the weil-clause can serve to unambiguously identify its reference clause. While verb-final weil-clauses can be used to refer to previous messages by both an interlocutor and oneself, verb-second weil-clauses are predominantly used to relate to an own previous message. Thus, the syntactic variation in weil-clauses can be used for disambiguating references in written interactions.
Referring to other participants in asynchronous online discussions: Citation patterns in a higher education context
Authors: Cal-Varela Mario , Fernández-Polo Francisco Javier 
Published: October 2022

Abstract
The effectiveness of asynchronous online discussions as a learning tool in higher education critically depends on the participants’ ability to create a cohesive social space. Referring to one another’s messages is a key way to display a sense of affiliation and solidarity, and contribute to the consolidation of the learning community. However, research has shown that students often fail to adequately exploit this dimension of the online forum, as it requires considerable involvement in the activity and is very time-consuming.In the current study, we examined references to previous posts in a set of online discussions held during a one-term undergraduate course. The overall frequency of citations was low, with slightly over half of the 885 analyzed posts containing at least one reference. While this seems to indicate that a large number of participants conceived the activity as hardly interactive, for those who did quote their classmates, the preferred practice was using their first names, although the more formal name+surname pattern increased in the second half of the course, possibly indicating an awareness of the academic character of the activity. If the frequency and kind of mutual references can be taken as a measure of how successful asynchronous online discussions can prove as a collaborative learning tool, our results invite deep reflection regarding task design to ensure that students and instructors understand their goals in the same way.