bluuebunny/crossref_metadata_2025_split huggingface dataset:
Donor liquid biopsy and outcomes in kidney transplantation
Authors: Anfaiha-Sanchez Miriam , Rodrigo Calabia Emilio , Ortiz Alberto , Martin-Lorenzo Marta , Alvarez-Llamas Gloria 
Published: October 2022

ABSTRACTKidney transplantation is the treatment of choice for patients with kidney failure. Priority on the waiting list and optimal donor–recipient matching are guided by mathematical scores, clinical variables and macroscopic observation of the donated organ. Despite the increasing rates of successful kidney transplantation, maximizing the number of available organs while ensuring the optimum long-term performance of the transplanted kidney remains both key and challenging, and no unequivocal markers are available for clinical decision making. Moreover, the majority of studies performed thus far has focused on the risk of primary non-function and delayed graft function and subsequent survival and have mainly analysed recipients’ samples. Given the increasing use of donors with expanded criteria and/or cardiac death, predicting whether grafts will provide sufficient kidney function is increasingly more challenging. Here we compile the available tools for pre-transplant kidney evaluation and summarize the latest molecular data from donors that may predict short-term (immediate or delayed graft function), medium-term (6 months) and long-term (≥12 months) kidney function. The use of liquid biopsy (urine, serum, plasma) to overcome the limitations of the pre-transplant histological evaluation is proposed. Novel molecules and approaches such as the use of urinary extracellular vesicles are also reviewed and discussed, along with directions for future research.
Dynamic demand for differentiated products with fixed-effects unobserved heterogeneity
Authors: Aguirregabiria Victor 
Published: October 2022

SummaryThis paper studies identification and estimation of a dynamic discrete choice model of demand for differentiated product using consumer-level panel data with few purchase events per consumer (i.e., short panel). Consumers are forward-looking and their preferences incorporate two sources of dynamics: last choice dependence due to habits and switching costs, and duration dependence due to inventory, depreciation, or learning. A key distinguishing feature of the model is that consumer unobserved heterogeneity has a Fixed Effects structure; that is, its probability distribution conditional on the initial values of endogenous state variables is unrestricted. I apply and extend recent results to establish the identification of all the structural parameters as long as the dataset includes four or more purchase events per household. The parameters can be estimated using a sufficient statistic—conditional maximum likelihood (CML) method. An attractive feature of CML in this model is that the sufficient statistic controls for the forward-looking value of the consumer’s decision problem, such that the method does not require solving dynamic programming problems or calculating expected present values.
Fifteen-year secular changes in the care and outcomes of patients with out-of-hospital cardiac arrest in Japan: a nationwide, population-based study
Authors: Shibahashi Keita , Kato Taichi , Hikone Mayu , Sugiyama Kazuhiro 
Published: October 2022

Abstract

Aims
Countries have implemented initiatives to improve the outcomes of patients with out-of-hospital cardiac arrest (OHCA). However, secular changes in care and outcomes at the national level have not been extensively investigated. This study aimed to determine 15-year secular changes in the outcomes of such patients in Japan.

Methods and results
Using population-based data of patients with OHCA, covering all populations in Japan (2005–19), patients for whom resuscitation was attempted were identified. The primary outcome was a favourable neurological outcome (Cerebral Performance Category 1 or 2: sufficient cerebral function for independent activities of daily life and work in a sheltered environment). Secular changes in outcomes were determined using a mixed-level multivariate logistic regression analysis. Overall, 1 764 440 patients (42.4% women; median age, 78 years) were examined. The incidence, median age, and proportion of patients who received bystander cardiopulmonary resuscitation (CPR) and dispatcher instructions for resuscitation increased significantly during the study period (P &lt; 0.001). A significant trend was noted toward improved outcomes over time (P for trend &lt; 0.001); favourable neurological outcome proportions 1 month after arrest increased from 1.7–3.0% (odds ratio, 1.03 per 1-incremental year). A remarkable increase was noted in favourable neurological outcomes in younger patients and patients with initial shockable cardiac rhythm, while improvement varied among prefectures.

Conclusion
In Japan, collaborative efforts have yielded commendable achievements in the care and outcomes of patients with OHCA over 15 years through to 2019, while the improvement depended on patient characteristics. Further initiatives are needed to improve OHCA outcomes.
Data standards for atrial fibrillation/flutter and catheter ablation: the European Unified Registries for Heart Care Evaluation and Randomized Trials (EuroHeart)
Authors: Batra Gorav , Aktaa Suleman , Camm A John , Costa Francisco , Di Biase Luigi , Duncker David , Fauchier Laurent , Fragakis Nikolaos , Frost Lars , Hijazi Ziad , Juhlin Tord , Merino José L , Mont Lluis , Nielsen Jens C , Oldgren Jonas , Polewczyk Anna , Potpara Tatjana , Sacher Frederic , Sommer Philipp , Tilz Roland , Maggioni Aldo P , Wallentin Lars , Casadei Barbara , Gale Chris P 
Published: October 2022

Abstract

Aims
Standardized data definitions are essential for monitoring and assessment of care and outcomes in observational studies and randomized controlled trials (RCTs). The European Unified Registries for Heart Care Evaluation and Randomized Trials (EuroHeart) project of the European Society of Cardiology aimed to develop contemporary data standards for atrial fibrillation/flutter (AF/AFL) and catheter ablation.

Methods and results
We used the EuroHeart methodology for the development of data standards and formed a Working Group comprising 23 experts in AF/AFL and catheter ablation registries, as well as representatives from the European Heart Rhythm Association and EuroHeart. We conducted a systematic literature review of AF/AFL and catheter ablation registries and data standard documents to generate candidate variables. We used a modified Delphi method to reach a consensus on a final variable set. For each variable, the Working Group developed permissible values and definitions, and agreed as to whether the variable was mandatory (Level 1) or additional (Level 2). In total, 70 Level 1 and 92 Level 2 variables were selected and reviewed by a wider Reference Group of 42 experts from 24 countries. The Level 1 variables were implemented into the EuroHeart IT platform as the basis for continuous registration of individual patient data.

Conclusion
By means of a structured process and working with international stakeholders, harmonized data standards for AF/AFL and catheter ablation for AF/AFL were developed. In the context of the EuroHeart project, this will facilitate country-level quality of care improvement, international observational research, registry-based RCTs, and post-marketing surveillance of devices and pharmacotherapies.
Factor XI inhibitors: cardiovascular perspectives
Authors: De Caterina Raffaele , Prisco Domenico , Eikelboom John W 
Published: October 2022

Abstract
Anticoagulants are the cornerstone for prevention and treatment of thrombosis but are not completely effective, and concerns about the risk of bleeding continue to limit their uptake. Animal studies and experience from patients with genetic coagulation factor XI deficiency suggesting that this factor is more important for thrombosis than for haemostasis raises the potential for drugs that target factor XI to provide safer anticoagulation. Multiple factor XI inhibitors are currently under evaluation in clinical trials, including parenterally administered antisense oligonucleotides, monoclonal antibodies, and orally active small-molecule inhibitors. Promising results of phase 2 trials in patients undergoing major orthopaedic surgery, and in those with end-stage kidney disease, atrial fibrillation and acute coronary syndromes have led to large phase 3 trials that are currently ongoing. We here review premises for the use of these agents, results so far accrued, ongoing studies, and perspectives for future patient care.
Detection of pneumococcus during hospitalization for SARS-CoV-2
Authors: Stahlfeld Anne , Glick Laura R , Ott Isabel M , Craft Samuel B , Yolda-Carr Devyn , Harden Christina A , Nakahata Maura , Farhadian Shelli F , Grant Lindsay R , Alexander-Parrish Ronika , Arguedas Adriano , Gessner Bradford D , Weinberger Daniel M , Wyllie Anne L 
Published: October 2022

Abstract

Background
Infections with respiratory viruses [e.g. influenza and respiratory syncytial virus (RSV)] can increase the risk of severe pneumococcal infections. Likewise, pneumococcal coinfection is associated with poorer outcomes in viral respiratory infection. However, there are limited data describing the frequency of pneumococcus and SARS-CoV-2 coinfection and the role of coinfection in influencing COVID-19 severity. We, therefore, investigated the detection of pneumococcus in COVID-19 inpatients during the early pandemic period.

Methods
The study included patients aged 18 years and older, admitted to the Yale-New Haven Hospital who were symptomatic for respiratory infection and tested positive for SARS-CoV-2 during March–August 2020. Patients were tested for pneumococcus through culture-enrichment of saliva followed by RT-qPCR (to identify carriage) and serotype-specific urine antigen detection (UAD) assays (to identify presumed lower respiratory tract pneumococcal disease).

Results
Among 148 subjects, the median age was 65 years; 54.7% were male; 50.7% had an ICU stay; 64.9% received antibiotics; and 14.9% died while admitted. Pneumococcal carriage was detected in 3/96 (3.1%) individuals tested by saliva RT-qPCR. Additionally, pneumococcus was detected in 14/127 (11.0%) individuals tested by UAD, and more commonly in severe than moderate COVID-19 [OR: 2.20; 95% CI: (0.72, 7.48)]; however, the numbers were small with a high degree of uncertainty. None of the UAD-positive individuals died.

Conclusions
Pneumococcal lower respiratory tract infection (LRTI), as detected by positive UAD, occurred in patients hospitalized with COVID-19. Moreover, pneumococcal LRTI was more common in those with more serious COVID-19 outcomes. Future studies should assess how pneumococcus and SARS-CoV-2 interact to influence COVID-19 severity in hospitalized patients.
The efficacy and safety of thalidomide in the treatment of refractory Crohn's disease in adults: a double-center, double-blind, randomized–controlled trial
Authors: Peng Xiang , Lin Zi-Wen , Zhang Min , Yao Jia-Yin , Zhao Jun-Zhang , Hu Pin-Jin , Cao Qian , Zhi Min 
Published: October 2022

Abstract

Background
Thalidomide is applied in therapy for refractory Crohn's disease (CD) in adults, but systematic and rigorous clinical evidence is scant. The aim was to provide theoretical references for the efficacy of thalidomide in the therapy for refractory CD in adults.

Methods
A double-center, double-blind, placebo-controlled, randomized clinical trial of refractory CD in adults in two inflammatory bowel disease centers in China. In the double-blind trial, patients were randomly assigned to 100 mg of thalidomide or placebo daily for 8 weeks. The primary outcome was considered as the clinical remission rate calculated based on the Crohn's disease activity index at the eighth week following thalidomide or placebo treatment. In open label, non-response to placebo was additionally treated with 8 weeks of thalidomide; all responders were continuously treated with thalidomide until the 48th week.

Results
Twenty-five patients were randomly assigned to each group. At the eighth week, the clinical remission rate in the thalidomide group was significantly higher than that in the placebo group (68.0% [17/25] vs 16.0% [4/25]; relative risk, 4.2; 95% confidence interval, 1.8–10.9, P &lt; 0.001). After a 48-week follow-up, the continuous treatment rate of thalidomide was 46.3% (19/41). Adverse events during the whole process were reported in 58.5% of patients, mainly involving drowsiness, rash, and peripheral neuropathy that were mild and tolerable.

Conclusion
Thalidomide can be used in the induction and maintenance therapy of refractory CD in adults. And it could be one of the treatment options for refractory CD.
Sample2Sample: an improved self-supervised denoising framework for random noise suppression in distributed acoustic sensing vertical seismic profile data
Authors: Zhao Y X , Li Y , Wu N , Wang S N 
Published: October 2022

SUMMARYThe performance of supervised deep learning-based denoising methods relies on massive amounts of high-quality training data set with labels. However, data labelling is a time-consuming and tedious process, and the lack of labelled data set has become a major bottleneck affecting the development of supervised deep learning-based denoising methods. In recent years, denoising methods that only use unlabelled noisy data set for training have received more and more attention. Although these methods get rid of the dependence on labels, they usually have some specific requirements on the training data set. For example, the paired training data are required to be multiple noisy observations for each scene or obey a specific noise distribution, etc., which are often very challenging to meet in practical applications. In this study, we propose an improved self-supervised denoising framework based on Noise2Noise that only uses noisy seismic data set for training, and we name it sample2sample. The proposed denoising framework does not require multiple repeated acquisitions of seismic data to obtain multiple independent noisy observations for each scene used for training, and has no specific requirement for the noise distribution prior. Specifically, we introduce a random sampler to generate paired subsamples from some individual noisy seismic data for training. The corresponding elements in the two paired subsamples are adjacent in the original seismic data and approximately meet the training premise of Noise2Noise, that is the paired training data have the same signal. In addition, considering that there are some subtle differences in the signals of the paired subsamples generated by sampling, we also introduce a regularization loss to compensate for this. We conducted a qualitative and quantitative analysis of the denoising performance of the proposed method through further experiments, including synthetic data experiments and field data experiments.
Simulation of thermoelastic wave propagation in 3-D multilayered half-space media
Authors: Yang Bo , Li Zhengbo , Zeng Ling , Chen Xiaofei 
Published: October 2022

SUMMARY
Thermal phenomena are common in both the generation and propagation of seismic waves. To investigate the propagation characteristics of thermoelastic waves generated by point sources in a 3-D multilayered half-space, herein, we develop a method that can solve problems involving coupled mechanical and thermal motions. The method first transforms the governing equations into two sets of first-order ordinary differential equations with a unified form in the frequency–wavenumber domain and then solves them by a generalized reflection and transmission coefficient method. To verify the correctness of our method and the corresponding computer program, we compare our solutions with analytical solutions. We further apply the method to different multilayered models, and the numerical results clearly demonstrate the reflection and transmission phenomena of thermoelastic waves within the interlayer. Furthermore, the generated thermal and seismic signals are synchronous, and the two P waves predicted by generalized thermoelastic theory can be converted into each other. The records on the ground show that thermal motions influence our observation of direct waves, especially in the presence of high thermal conductivity subsurface media, it can significantly impact the propagation of both body and surface waves, making surface seismic observations more complex than those predicted by elastic theory.
New insights into the Rhône–Simplon fault system (Swiss Alps) from a consistent earthquake catalogue covering 35 yr
Authors: Lee Timothy , Diehl Tobias , Kissling Edi , Wiemer Stefan 
Published: October 2022

SUMMARYSeismotectonic interpretations in regions characterized by low to moderate seismicity require consistent earthquake catalogues covering periods of several decades. Inevitable changes in network configuration and analysing procedures, however, introduce significant bias to the hypocentre parameters and uncertainty estimates reported in such catalogues. To overcome these limitations, we developed a procedure using coupled hypocentre-velocity inversions to compute consistent hypocentre locations covering time periods of several decades while accounting for changes in network geometry. We apply these procedures to 35 yr of instrumentally recorded seismicity along the Rhône–Simplon fault system in southwest Switzerland, which is at the transition between the Central and Western Alps. The entire catalogue is relocated using a probabilistic location algorithm in combination with the derived minimum 1-D velocity models. A combination of location parameters is used to define consistent location-quality classes allowing for reliable interpretation of epicentres and focal depths. The relocated catalogue is interpreted together with a recent 3-D P-wave tomographic model and available 2-D reflection seismic profiles. The relocated hypocentres indicate that the major band of seismicity north of the Rhône valley is associated with a 30–40 km long, steeply north-dipping shear zone, which roots in the crystalline basement of the Aar Massif and extends to the shallowest levels of the sedimentary cover of the Helvetic nappes in the Rawil Depression. Seismicity towards the southwest indicates the existence of a similar shear zone within the Aiguille Rouge Massif. This zone possibly extends to the northeast and joins the Rawil fault zone. To the south of the Rhône valley, seismicity is scattered within the Penninic nappes, but limited to the hanging wall of the Pennine Basal Thrust (PBT). The Penninic nappes are characterized by a relatively higher VP of about 5 per cent compared to the Aar Massif, indicating differences in composition or metamorphic grade across the PBT.
How China lost its wolf pack: the fracturing of the emerging-power alliance at the WTO
Authors: Hopewell Kristen 
Published: October 2022

Abstract
There has been considerable debate about the capacity of emerging powers, such as the BRICS (Brazil, India, China, South Africa), to act as a unified and coherent force in global economic governance. In the case of the World Trade Organization (WTO), strategic cooperation and alliance-building among the emerging powers—specifically Brazil, India and China (BIC)—were essential to counterbalancing the US and other traditional powers and enabling the rising powers to defend their interests. However, as this article shows, the BIC alliance at the WTO has collapsed. The core issue that historically united the emerging powers and provided the foundation for their alliance was ‘special and differential treatment’ (SDT) for developing countries. Yet both Brazil and India have now defected from the alliance, abandoning China. Brazil was the first to defect, switching sides and realigning itself with the US; the change in its alliance calculations reflected shifting economic priorities and a fundamental reorientation of its foreign policy strategy away from its earlier Third Worldism. India then defected when its alliance with China, once an important source of strength in WTO negotiations, instead became a liability. As a result, having lost its key allies at the WTO, China is increasingly isolated in multilateral trade negotiations.
Localizing refugeehood: norms and the US resettlement of Afghan allies
Authors: Coen Alise 
Published: October 2022

Abstract
A central challenge for the study of norms in International Relations entails understanding how meaning is enacted through use and local context. Amid trends towards governments reducing pathways of humanitarian migration, local constructions of meaning around refugeehood and the obligations owed to people fleeing persecution can influence global trajectories of containment and responsibility-sharing. As a means of advancing our understanding of norm localization and contestation, this article provides an account of how obligations around refugee protection are configured and contested among national and subnational authorities. Using a case study of discourses (re)produced among United States' federal, state and municipal leaders, it explores the multiple, complex layers of meaning which emerged around duties of care owed to foreign civilian ‘allies’ in the context of the 2021 Taliban takeover of Afghanistan. Beyond illustrating dynamics of localization and contestation, the article shows how domestic resistance to norm implementation can operate as a surrogate for wider visions of resisting liberal international principles. The case study more broadly contributes to understanding the conflicting logics associated with duties of care in the aftermath of military interventions.
Bone Density Variation in Rattails (Macrouridae, Gadiformes): Buoyancy, Depth, Body Size, and Feeding
Authors: Martin Rene P , Dias Abigail S , Summers Adam P , Gerringer Mackenzie E 
Published: October 2022

Synopsis
Extreme abiotic factors in deep-sea environments, such as near-freezing temperatures, low light, and high hydrostatic pressure, drive the evolution of adaptations that allow organisms to survive under these conditions. Pelagic and benthopelagic fishes that have invaded the deep sea face physiological challenges from increased compression of gasses at depth, which limits the use of gas cavities as a buoyancy aid. One adaptation observed in deep-sea fishes to increase buoyancy is a decrease of high-density tissues. In this study, we analyze mineralization of high-density skeletal tissue in rattails (family Macrouridae), a group of widespread benthopelagic fishes that occur from surface waters to greater than 7000 m depth. We test the hypothesis that rattail species decrease bone density with increasing habitat depth as an adaptation to maintaining buoyancy while living under high hydrostatic pressures. We performed micro-computed tomography (micro-CT) scans on 15 species and 20 specimens of rattails and included two standards of known hydroxyapatite concentration (phantoms) to approximate voxel brightness to bone density. Bone density was compared across four bones (eleventh vertebra, lower jaw, pelvic girdle, and first dorsal-fin pterygiophore). On average, the lower jaw was significantly denser than the other bones. We found no correlation between bone density and depth or between bone density and phylogenetic relationships. Instead, we observed that bone density increases with increasing specimen length within and between species. This study adds to the growing body of work that suggests bone density can increase with growth in fishes, and that bone density does not vary in a straightforward way with depth.