Sex differences in the impact of coronary artery disease on long-term survival after transcatheter aortic valve implantation
Authors: Minten L , Wissels P , McCutcheon K , Desmet W , Bennett J , Dubois C 
Published: October 2022

Abstract

Background
It has been suggested that the complexity of coronary artery disease (CAD) is a determinant of worse outcomes after transcatheter aortic valve implantation (TAVI). However, no data is available showing this applies equally to both sexes.

Purpose
Males are usually overrepresented in studies regarding CAD and care should be used when translating these results to the female population. The purpose of this analysis was to compare sex specific clinical outcomes in patients undergoing TAVI with and without coexisting CAD.

Methods
All patients undergoing TAVI at a tertiary referral centre between 2008 and 2020 were included and outcomes up to five years after TAVI were prospectively recorded. Baseline and residual (after revascularization) SYNTAX-scores (SS) were retrospectively calculated to make groups of different CAD complexity.

Results
A total of 605 patients, of whome 284 (46.9%) female patients, underwent TAVI. Five years after TAVI, females and males had similar overall survival (62 vs 59%, p=0.320) and cardiovascular mortality (22% vs 20%, p=0.540), respectively. Females were older (82.7y vs 80.8y, p&lt;0.001), had a higher left ventricular ejection fraction (53.7% vs 49.4%, p&lt;0.001) and higher aortic valve mean gradient (45.7 vs 41.6 mmHg, p=0.002). EuroScore II was comparable between both groups (26.8 vs 27.5, p=0.330). Females had less obstructive CAD (49% vs 64%, p&lt;0.001) and less complex CAD (mean SS: 8.3 vs 12.6, p&lt;0.001), despite reporting similar rates of angina (10% vs 11%, p=0.492). While in males CAD complexity was not predictive of survival (fig 1A) or cardiovascular mortality (fig 2A), females showed worse survival (fig 1B) and cardiovascular mortality (fig 2B) with increasing CAD complexity. This difference seems not to be driven by a lower rate of revascularization since women with CAD received significantly more percutaneous coronary interventions (PCI) (41% vs 24%, p=0.001) and trended towards more complete revascularization (residual SS &lt;8 70% in females vs 52% in males, p=0.054). Background medical therapy with aspirin (70% vs 72%, p=0.710), other antiplatelet agents (61% vs 57%, p=0.390) and statins (71% vs 81%, p=0.065) was not different between both groups. A possible explanation for the similar rates of angina despite less complex CAD in females might be a higher prevalence of underlying microvascular dysfunction, which is also known to be related with an increased rate of cardiovascular events.

Conclusion
We show that in females outcomes after TAVI are significantly influenced by co-existing CAD and its complexity, while in males this is less pronounced. We identified a subgroup of females with a SS &gt;22 that are at particular high risk for fatal cardiovascular events after TAVI. Therefore, awareness for CAD and close follow-up in combination with guideline-directed treatment of complex CAD in females undergoing TAVI is crucial.

Funding Acknowledgement
Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Research Foundation Flanders