bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formation of the identity of a modern university in the logic of the neo-institutional concept of D. Nort
Authors: Nikitenko E. V. 
Published: May 2022

Introduction. The change in the general concept of university development in Russia in the context of the University 3.0 model allowed us to consider the university as an independent economic agent on the market. This allowed to apply neo-institutional approach of Douglass C. North.Purpose setting. The process of shaping a new identity of higher education is determined by the ongoing institutional renewal. The article is devoted to identifying and analyzing the conditions that determine the formation of a new university identity in the logic of D. North’s neo-institutional concept.Methodology of the study. The appeal to the neo-institutional approach arose in connection with the need to trace and assess the changes that have occurred and will occur to the university in the context of interaction with society, government and business, as well as to identify the set of conditions that will contribute to the formation of a new identity of the university. The concepts of formal and informal constraints, which determine the possible institutional changes, were considered as methodological concepts of D. North’s theory.Results. An important condition for the functioning of an institution is a set of formal and informal attitudes, to which we respectively refer laws/codes, on the one hand, traditions and customs on the other. These concepts are closely related to the concepts of ideology and the market, which also influence changes in the system of restrictions. According to D. North, institutional changes are possible when formal and informal frameworks are updated. The article shows that with formal changes brought from above, the image of classical university as a social institution is still preserved, the market is also not ready to perceive the university as an independent economic agent, as one of the stakeholders of entrepreneurial and innovative activity.Conclusions. The problem of contradiction between the preferences of subjects of educational, entrepreneurial and innovative activity becomes obvious. Serious restraining factors are the absence of regulatory framework explaining the mechanism of interaction between private business and the state, the preservation of the image of a classical university, the lack of coherence and consistency of institutional changes.
Oxygen Uptake Response to Switching Stairs Exercise by Non-parametric Modeling
Authors: Yu Hairong , Xie Tian , Su Steven 
Published: May 2022

Abstract

Oxygen uptake plays a vital role in evaluating endurance performance during exercise and is widely used for metabolic assessment. In this study, the oxygen uptake during the exercise phase (i.e. ascending or descending) of the stairs exercise are recorded and the experimental dataset features ten participants and a range of different exercise periods. Based on the designed experiment protocol, a non-parametric modeling method with kernel-based regularization is generally applied to estimate the oxygen uptake changes during the switching stairs exercise that is close to the daily life status. Compared with the fixed-order models on accuracy, stability and compatibility, the modeling results demonstrate the effectiveness of the non-parametric modeling approach. The influence of exercise duration on estimated fitness reveals that the model of the phase-oxygen uptake system is not time-invariant related to respiratory metabolism regulation and muscle fatigue. Accordingly, it allows us to study the humans' conversion mechanism at different metabolic rates and facilitates the standardization and development of exercise prescriptions.
Integrated analysis of LRP2 mutation to immunotherapy efficacy in pan-cancer cohort
Authors: Li Chunbo , Ding Yan , Zhang Xuyin , Hua Keqin 
Published: May 2022

Abstract
Purpose Immunotherapy has emerged as a novel therapy, while many patients are refractory. Although, several biomarkers have been identified as predictive biomarkers for immunotherapy, such as tumor specific genes, PD-1/PD-L1, tumor mutation burn (TMB), and microsatellite instability (MSI), results remain unsatisfactory.Methods We investigated the characteristics of low-density lipoprotein receptor-related protein 2 (LRP2) mutation in the cancer genome atlas (TCGA) and explored the potential association of LRP2 mutation with immunotherapy. Characteristic of LRP2 mutation in 33 cancer types was analyzed using large-scale public data. The association of LRP2 mutation with immune cell infiltration and immunotherapy efficacy was evaluated. Finally, a LPR2 mutation signature (LMS) was developed and validated by TCGA-UCEC and pan-cancer cohorts. Furthermore, we demonstrated the predictive power of LMS score in independent immunotherapy cohorts by performing a meta-analysis.Results Our results revealed that patients with LRP2 mutant had higher TMB and MSI compared with patients without LRP2 mutation. Meanwhile, LRP2 mutation was associated with higher infiltration level of immune cells and higher expression of immune-related genes and signaling pathways. Patients with LRP2 mutation presented long overall survival (OS) after immunotherapy. In endothelial cancer (EC), patients with LRP2 mutation belonged to the POLE and MSI-H type of EC molecular types, with a better prognosis. Finally, we developed a LRP2 mutation signature (LMS), that was significantly associated with prognosis in patients receiving immunotherapy.Conclusion These results indicated that LRP2 mutation can serve as a biomarker for the personalization of cancer immunotherapy. Importantly, LMS is a potential predictor of patients prognosis after immunotherapy.
Identification of Health Effects of Complex Air Pollution in China
Authors: Zhao Yuxin , An Xingqin , Sun Zhaobin , Li Yi , Hou Qing 
Published: May 2022

Abstract
With the progress of air pollution control in China, the concentration of particulate matter has decreased, but the concentration of ozone has increased, the problem of complex air pollution has become more severe, posing a serious threat to public health. However, there is less study on the health effects of complex air pollution in China. Instead of introducing pollutant concentrations directly, we converted them into a set of predictors to prevent collinearity and other problems will occur when the concentrations of multiple correlated pollutants are introduced in general multi-pollution models. Based on different combinations of PM2.5, NO2, and O3 concentration levels, air pollutant constituent condition is divided into eight types, including three single-pollutant types and four multi-pollutant types. The health effects of different pollution types on mortality in eight typical Chinese cities from 2013 to 2016 were evaluated using a generalized additive model. The results from eight cities collectively indicate that multi-pollutant type leads to a higher impact on mortality risk than single-pollutant type. Type 7 with higher PM2.5, O3, and NO2 and type 4 with higher PM2.5 and NO2 have a greater relative risk among them. In most northern cities, the multi-pollutant type has a higher mortality effect in the warm season, but the single-pollutant type with high PM2.5 has a higher effect in the cold season. In southeastern cities, the multi-pollutant type had a higher mortality effect in both seasons. The results also showed that the excess risk of multi-pollutants was less than the simple sum of individual air pollutants effects, partially false conclusions would have been reached by ignoring the presence of interactions between air pollutants. The result further highlights the urgency and necessity of moving towards a multi-pollutant approach in air pollution health research under the background of atmospheric emission reduction and global warming.
Antimalarial potential of Gymnema inodorum leaf extract and dihydroartemisinin combination against Plasmodium berghei infected mice
Authors: Ounjaijean Sakaewan , Somsak Voravuth 
Published: May 2022

Abstract
Chemotherapy plays a crucial role in malaria control. However, the main obstacle to treatment has been the rise of parasite resistance to most antimalarial drugs. Artemisinin-based combination therapies (ACTs) remain today’s most effective antimalarial therapies. However, malaria parasite tolerance to ACTs is now increasingly prevalent, especially in Southeast Asia. Consequently, this creates the need for effective alternative antimalarials. Interestingly, the effectiveness of Gymnema inodorum leaf extract (GIE) as an antimalarial candidate was reported earlier. Therefore, this study sought to evaluate the antimalarial potential of dihydroartemisinin (DHA) based combination therapy with GIE against Plasmodium berghei in a mouse model. Drug assessment was carried out on P. berghei ANKA (PbANKA) using the standard 4-day test for determination of fifty percent effective dose (ED50) of DHA and GIE individually. Moreover, the combination of DHA and GIE was also evaluated based on fixed-ratio strategy, 100/0, 80/20, 60/40, 40/60, 20/80, and 0/100 of ED50 of DHA and GIE, respectively. Overall, 2 mg/kg and 100 mg/kg of DHA and GIE resulted in ED50 against PbANKA. In combination, the ratio of 60/40 (DHA/GIE) had a considerable the highest antimalarial activity significantly (p < 0.001) against PbANKA with 88.95% inhibition that indicated a synergism efficacy (CI value = 0.68695). Additionally, this ratio was protected PbANKA infected mice from BW loss and PCV reduction with prolonged survival time throughout the 30 day follow up. This study points to better efficacy of GIE as an alternative drug partner in combination to enhance antimalarial efficacy of DHA against PbANKA infected mice.
A Combination of UV curing and thermal Treatment successfully overcomes PDMS Curing Inhibition on 3D-Printed low-cost-resin Molds
Authors: Grigorov Emil , Kirov Boris , Galabov Vassil 
Published: May 2022

Abstract
We investigate the influence of thermal and UV post-curing treat- ments on 3D printed resin mold and the quality of a pored poly- mer, polydimethylsiloxane, utilized in the world of microfluidics.
Seroprevalence of Toxoplasma gondii and associated risk factors among pregnant women attending antenatal care in Ilala Municipality, Dar es Salaam, Tanzania
Authors: Lushina Mayala , Mushi Vivian , Tarimo Donath , Babafemi Emmanuel Oladipo 
Published: May 2022

Abstract
BackgroundToxoplasma gondii (T. gondii) infection during pregnancy is associated with a variety of complications to the mother and baby. In Tanzania, there is a paucity of data on exposure T. gondii infection among pregnant women and the associated risk factors. Therefore, this study investigated the seroprevalence of T. gondii and associated factors among pregnant women attending antenatal care in Ilala Municipality, Dar es Salaam.MethodsA cross-sectional study was carried out among 383 pregnant women attending antenatal health care. A five mL of blood sample was collected from each of the recruited pregnant women, processed to obtain serum, and tested for the presence of IgG and IgM anti-T. gondii specific antibodies. A structured questionnaire was used to gather information on the risk factors predisposing pregnant women to the infection. Data analysis was performed using descriptive statistics and logistic regression. ResultsOf the 383 participants, 104 (27.2%) were positive for antibodies specific to T. gondii; 102 (26.63%) were positive only for IgG, and 2 (0.52%) were positive both for IgM and IgG antibodies. Significantly risk factors for T. gondii infection included: increased maternal age (34-39) years [AOR = 3.714, 95% CI:1.522-9.062), eating unwashed fruits [AOR = 7.385, 95% CI:3.994-13.658,], not washing hand with soap after meat preparation [AOR = 7.525, 95% CI:3.403-16.642], consumption of undercooked meat [AOR = 3.746, 95% CI:1.945-7.217], and consumption of raw vegetable [AOR = 1.986, 95% CI:1.038-3.800]. ConclusionsThe seroprevalence of T. gondii infection (27.2%), indicates ongoing transmission hence the need for regular screening during antenatal care and establishment of a control program.
Role of Denosumab in the Management of Giant Cell Tumor, A cross sectional study
Authors: Saeed Javeria , Ahmed kaleem sohail , Shamsi Zaid , Umer Masood 
Published: May 2022

Abstract
Background Giant cell tumor (GCT) of bone is a benign lesion which is characterized by presence of multinucleated osteoclasts type giant cells. Nuclear factor kappa B (RANKL) serves as the trigger factor for osteoclasts cells formation. Although surgery is the primary treatment for GCT of bone but recurrence remains the concern. Therefore, the development of denosumab, a monoclonal antibody for treating GCT for both primary and recurrent disease cases. The present study aims to show the role of denosumab along with surgery when given as neo-adjuvant drug to patients of GCT for their treatment.Methodology:A total of 23 patients diagnosed with GCT were included in this study from January 2016- December 2019 and all of these patients had received neo adjuvant denosumab dose of 120 mg SC on day 0, 15, 30 & 45. All patients were treated at the section of Orthopedics, department of surgery, Aga Khan University hospital, Karachi. Other benign lesions were excluded from the study.Results Out of 23 patients we had 12 (52.2%) males and 11 (47.8%) females. The mean age of our patients was 34 13.8 years and mean follow up duration of all patients was 20.5±10.7 months. There were 15 (65.2%) primary cases of GCT while 8 (34.8%) were recurrent cases. In 8 (34.8%) of the cases primary site of lesion was distal femur followed by 7(30.4%). In surgical procedure 20 (87%) patients underwent wide margin excision and only 3 (13%) had intralesional curettage. Reconstruction was performed in 21 patients which consist of bone grafting in 9 patients and mega prosthesis insertion in 12 patients. Only two patients had no reconstruction. On final histopathology, there was no residual GCT and we observed no denosumab induced adverse effects. Post-operative complications included wound infection and peri prosthetic infection in 3 patients. On follow-up we had 4(17.4%) cases of recurrence that were offered revision surgery while 19 (82.6%) were disease free.Conclusion:Denosumab has shown successful results in treating patients with GCT along with surgical intervention and it can be a best option for treating recurrent disease as well.Research registration no: researchregistry4695
Vibrational Resonance and Control of the Response of a Nonlinear Tilted Cantilever Beam under Combined Multi-harmonic Low and High-Frequency Excitations
Authors: Sahoo Pradyumna Kumar , Chatterjee Shyamal 
Published: May 2022

Abstract
This paper investigates the vibrational resonance and control of the response of a nonlinear tilted cantilever beam under combined multi-harmonic low and high-frequency excitations. The basic system considers the first mode of vibration of a nonlinear tilted beam under parametric and direct base excitation with the frequency components locked in 2:1 ratio. Such a system is susceptible to parametric amplification of resonance, which may be detrimental for structural health in many mechanical systems. The primary objective of the research is to investigate the efficacy of high-frequency excitation in controlling parametric amplification in the system. To the best of the authors' knowledge such a study was not reported previously in the literature. The slow dynamic equations of the system are obtained using the method of direct partition of motion (MDPM), which is then analysed using the harmonic balance method (HBM). It has been shown that the high-frequency base excitation has a considerable influence on the effective damping and stiffness of the system under consideration. The results of the research demonstrate that high-frequency excitation can effectively control the parametric amplification by shifting the resonance curve in the frequency axis and eliminate undesirable bifurcations by increasing the effective damping. The phenomenon of vibrational resonance has been found for certain parameter values in the presence of high-frequency base excitation. Detail parametric studies are performed to reveal the rich nonlinear dynamics of the system, like multiple jumps in response, dual peaks, isolated resonance response (isola), loop formation in frequency response plot, etc. The numerical results reveal that high-frequency excitation transforms chaotic responses into regular periodic responses. Direct numerical simulations are performed in MATLAB SIMULINK to validate the analytical results.
Effect of nifedipine administration before embryo transfer on reproductive outcome in ICSI cycles, a double-blind control trial study
Authors: Basirat Fatemeh , Esmaeilzadeh Sedighe , Basirat zahra , Ghofrani Faeze , Golsorkhtabaramiri Masoumeh 
Published: May 2022

Abstract

Purpose: Nifedipine is a calcium channel blocker with smooth muscle relaxing properties. This study set out to investigate the efficacy of nifedipine administered orally before embryo transfer (ET) on the improvement of the Intracytoplasmic sperm injection (ICSI) outcome.This double-blind placebo-control trial study was carried out in Babol (Iran) in 2019- 2020. 200 infertile women undergoing ET treatments were randomly allocated to receive nifedipine 20 mg tablets placebo orally 30 minutes before ET. The primary outcome was the chemical pregnancy rate. Implantation rate and clinical pregnancy were considered as the secondary outcome. Result: There is no significant difference (P> 0.05) in the number of oocytes and quality of embryos in the nifedipine and placebo groups. Despite increases in the rate of a chemical pregnancy, there were no statistical differences in the study group versus the comparison group (24% vs 14%, P=0.1, rate ratio 0.88, 95% CI, 0.77 to 1.01) respectively. In implantation rate, no statistically significant difference between the two groups was evident (20% vs 10%, P=0.07, rate ratio 0.88, 95% CI, 0.79 to 1.00) respectively. Also, no significant increase in clinical pregnancy was found compared with the placebo (17% vs 8%, P=0.26, rate ratio 0.90, 0.81 to 1.00).Conclusion: Nifedipine administered orally 30 minutes before embryo transfer did not improve the chemical pregnancy rate, implantation rate, or clinical pregnancy rate in women undergoing ICSI.
Hypoxia-induced reprogramming of glucose-dependent metabolic pathways maintains the stemness of human bone marrow-derived endothelial progenitor cells
Authors: Lin Dongni , Yan Kaihao , Chen Lingyun , Chen Junxiong , Xu Jianing , Xie Zhijing , Li Zhujun , Lin Shuo , Li Jinghuan , Chen Zhenzhou 
Published: May 2022

Abstract
BackgroundThe benefits of hypoxia for maintaining the stemness of cultured human endothelial progenitor cells (EPCs) have previously been demonstrated but the mechanisms responsible remain unclear. There is growing evidence to suggest a role for cellular metabolism in the regulation of stem cell fate and self-renewal. This study aimed at exploring changes in glucose metabolism and roles in maintaining EPC stemness under hypoxia.MethodsExtracellular flux analysis, LC-MS/MS and 13C tracing HPLC-QE-MS were used to establish EPC metabolic status. Then inhibitors of glucose metabolism were used to assess the impact of the dependent pathways on cell stemness. The key enzymes of glycolysis, tricarboxylic acid cycle (TCA), pentose phosphate pathway (PPP) and mitochondrial respiration were inhibited, and the cell survival rate, clone formation rate, mRNA expression of stemness markers, Nanog, Oct4, Klf4 and Sox2, and adenosine triphosphate (ATP) level were compared.ResultsReprogramming of pathways concerned with glucose metabolism was found under hypoxic conditions, including increased rates of flux through glycolysis and the pentose phosphate pathway (PPP), together with decreased flux through the tricarboxylic acid (TCA) cycle and mitochondrial respiration. Use of inhibitors of key enzymes of glycolysis, PPP, TCA cycle and the mitochondrial electron transport chain (ETC) revealed that inhibition of glycolysis or the PPP impaired cell proliferation under both normoxic and hypoxic conditions. By contrast, inhibition of pyruvate oxidation, via targeting of the TCA cycle or ETC, increased cell stemness under normoxic conditions. Moreover, promotion of pyruvate oxidation reversed the effect of hypoxia in maintaining cell stemness. Although hypoxia decreased mitochondrial ATP level, total cellular ATP level was unchanged, indicating that energy production does not play a major role in hypoxic effects. ConclusionIn summary, hypoxia-induced reprogramming of pathways involved in glucose metabolism maintained EPC stemness. Artificial manipulation of cell metabolism may be a way to regulate EPC stemness, thereby facilitating in vitro cell expansion.
Deep learning algorithm for the detection and 3D segmentation of maxillofacial bone lesions in CBCT
Authors: Yeshua Talia , Ladyzhensky Shmuel , Abu-Nasser Amal , Abdalla-Aslan Ragda , Boharon Tami , Itzhak-Pur Avital , Alexander Asher , Chaurasia Akhilanand , Leichter Isaac , Nadler Chen 
Published: May 2022

Abstract
Objectives: This study aimed to develop an automated deep-learning algorithm for the detection and 3D segmentation of incidental jaw lesions in maxillofacial CBCT scans.Materials and Methods: The dataset included 82 CBCT scans with and without histologically confirmed benign bone lesions, obtained from three CBCT devices using different imaging protocols. The dataset consisted of axial CBCT images and was divided into training dataset (20,214 axial images), validation dataset (4,530 axial images) and testing dataset (6,795 axial images). A Mask-RCNN based deep-learning algorithm segmented the bone lesion in each axial image. The analysis of sequential slices improved the mask RCNN performance and assisted in classifying each CBCT case as containing bone lesions or not. Thereafter, the algorithm generated a 3D segmentation of the lesions. Results: The accuracy of the algorithm for classifying each CBCT case as either containing bone lesions or not, was 100%. The algorithm performance for detecting lesions in individual axial images showed high sensitivity (95.9%) and high precision (98.9%).Conclusions: Our deep learning algorithm can detect incidental bone lesions in CBCT scans with high accuracy, high sensitivity and high precision and is highly recommended for bone lesion detection and follow-up in CBCT imaging. Clinical relevance: The increasing number of CBCT scans performed worldwide dictates a clinical need for developing an automated tool, which will review, detect and volumetrically demonstrate incidental bone lesions in CBCT scans with high accuracy and low false-positive rate.
Integrated shimming enables independently parallel NMR detection
Authors: Cheng Yen-Tse , Jouda Mazin , Korvink Jan G. 
Published: May 2022

Abstract
Two major technical challenges facing parallel nuclear magnetic resonance (NMR) spectroscopy, at the onset, include the need to achieve exceptional B0 homogeneity, and good inter-detector radiofrequency signal decoupling, and have remained technical obstacles that limit high throughput compound screening via NMR. In this contribution, we consider a compact detector system, consisting of two NMR ’unit cell’ resonators that implement parallel B0 shimming with parallel radiofrequency detection, as a prototype NMR environment, pointing the way towards achieving accelerated NMR analysis. The utility of our approach is established by achieving local field correction within the bore of a 1.05 T permanent magnet MRI. Our forerunner platform suppresses signal cross coupling down to −30 dB under a geometrical decoupled scheme, leading to a halving of the necessary inter-coil distance. In this permanent magnet enviroment, two decoupled parallel NMR detector sites simultaneously achieve improved spectral linewidth, from 270 Hz to 24 Hz.