bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indocyanine green potentiated paclitaxel nanoprodrugs for imaging and chemotherapy
Authors: Xiang Xiujuan , Feng Xuan , Lu Shaojin , Jiang Bowen , Hao Dengyuan , Pei Qing , Xie Zhigang , Jing Xiabin 
Published: June 2022

AbstractSelf‐assembled prodrug nanoparticles with tumor‐responsive capacity have great potential in tumor visualization and treatment. However, the nanoparticle formulas usually contain multiple components, especially polymeric materials, which result in various potential issues. Herein, we report an indocyanine green (ICG)‐driven assembly of paclitaxel prodrugs integrating near‐infrared fluorescence imaging and tumor‐specific chemotherapy. By feat of the hydrophilic merit of ICG, paclitaxel dimer could form more uniformly monodispersed nanoparticles. This two‐in‐one strategy reinforces the complementary advantages, resulting in superior assembly behavior, robust colloidal stability, enhanced tumor accumulation as well as desirable near‐infrared imaging and in vivo feedback of chemotherapy. The in vivo experiments validated the prodrug activation at tumor sites as evidenced by enhanced fluorescence intensity, potent tumor growth suppression, and reduced systemic toxicity compared with commercial Taxol. The universality of ICG potentiated strategy toward photosensitizers and fluorescence dyes was confirmed. This presentation provides deep insight into the feasibility of constructing clinical‐close alternatives for improving antitumor efficacy.
Consumer choice and public‐private providers: The role of perceived prices
Authors: Lim Kai Shen , Yap Wei Aun , Yip Winnie 
Published: June 2022

AbstractGovernments often encourage health service providers to improve quality of care and reduce prices through competition. The efficacy of competition hinges on the assumption that consumers demand high quality care at low prices for any given health condition. In this paper, we examine this assumption by investigating the role of perceived price and quality on consumer choice for four different health conditions across public and private providers. We use a nationally representative survey in Malaysia to elicit respondents' perception on prices and quality, and their preferred choice of provider. We estimate a mixed logit model and show that consumers value different dimensions of quality depending on the health condition. Furthermore, increasing perceived prices for private providers reduces demand for minor, more frequent health conditions such as flu fever or cough, but increases demand for more complex, severe conditions such as coronary artery bypass graft. These findings provide empirical support for price regulation which differentiates the severity of underlying health conditions.
Care friendliness in adolescent sexual and reproductive health services in Mexico and a characterisation of their clients
Authors: García‐Bello Luis Alberto , Heredia‐Pi Ileana Beatriz , Zavala‐Arciniega Luis , Paz‐Ballesteros Wayra , Velázquez‐Viamonte Ailen , Serván‐Mori Edson 
Published: June 2022

AbstractBackgroundSexual and reproductive health (SRH) is a very important issue in public health programs in low ‐and middle‐income countries (LMICs). Health services that meet specific and differentiated needs of adolescents are increasingly relevant in LMICs. To provide quality services, it is necessary to know the profile of its users and the perspective that adolescents have about SRH services aimed at them.MethodsWe conducted a cross‐sectional analysis of primary data from a survey of 489 adolescents recruited in 11 primary‐care facilities in the state of Morelos, Mexico. We followed the guidelines outlined in the World Health Organization Quality Assessment Guidebook: A guide to assessing health services for adolescent clients. Data on friendliness of services were obtained through 70 questions divided into 18 characteristics which, in turn, were grouped into five domains: equity, accessibility, acceptability, appropriateness, and effectiveness. The “friendliness” (a proxy for quality of care) of services was measured according to an additive index of friendliness (FI) ranging from 0 (no friendliness) to 1 (maximum friendliness). We also described the socio‐demographic, SRH, and service utilization profiles of clients.ResultsThe health services analysed were characterised as having low levels of accessibility (FI = 0.62) and effectiveness (FI = 0.77), moderate acceptability (FI = 0.84), and high levels of appropriateness (FI = 0.93) and equity (FI = 0.92). Of the total number of adolescents surveyed, 51% stated that they had initiated a sexual life, 37% did not use any method of protection during their first sexual intercourse and 64% of the adolescents had already experienced a pregnancy.ConclusionsIt is essential to improve the accessibility and effectiveness dimensions of adolescent‐friendly services in Mexico. This requires the implementation of strategies specifically designed to promote well‐informed, planned and healthy sexual behaviours that avert risk and vulnerability. Strategies need to consider the profile of the adolescent client population.
The mitochondrial associated endoplasmic reticulum membranes: A platform for the pathogenesis of inflammation‐mediated metabolic diseases
Authors: Degechisa Sisay T. , Dabi Yosef T. , Gizaw Solomon T. 
Published: June 2022

AbstractMitochondria‐associated endoplasmic reticulum membranes (MAM) are specialized subcellular compartments that are shaped by endoplasmic reticulum (ER) subdomains placed side by side to the outer membrane of mitochondria (OMM) being connected by tethering proteins in mammalian cells. Studies showed that MAM has multiple physiological functions. These include regulation of lipid synthesis and transport, Ca2+ transport and signaling, mitochondrial dynamics, apoptosis, autophagy, and formation and activation of an inflammasome. However, alterations of MAM integrity lead to deleterious effects due to an increased generation of mitochondrial reactive oxygen species (ROS) via increased Ca2+ transfer from the ER to mitochondria. This, in turn, causes mitochondrial damage and release of mitochondrial components into the cytosol as damage‐associated molecular patterns which rapidly activate MAM‐resident Nod‐like receptor protein‐3 (NLRP3) inflammasome components. This complex induces the release of pro‐inflammatory cytokines that initiate low‐grade chronic inflammation that subsequently causes the development of metabolic diseases. But, the mechanisms of how MAM is involved in the pathogenesis of these diseases are not exhaustively reviewed. Therefore, this review was aimed to highlight the contribution of MAM to a variety of cellular functions and consider its significance pertaining to the pathogenesis of inflammation‐mediated metabolic diseases.
Reduced cutaneous CD200:CD200R1 signaling in psoriasis enhances neutrophil recruitment to skin
Authors: Linley Holly , Jaigirdar Shafqat , Mohamed Karishma , Griffiths Christopher E. M. , Saunders Amy 
Published: June 2022

AbstractIntroductionThe skin immune system is tightly regulated to prevent inappropriate inflammation in response to harmless environmental substances. This regulation is actively maintained by mechanisms including cytokines and cell surface receptors and its loss results in inflammatory disease. In the case of psoriasis, inappropriate immune activation leads to IL‐17‐driven chronic inflammation, but molecular mechanisms underlying this loss of regulation are not well understood. Immunoglobulin family member CD200 and its receptor, CD200R1, are important regulators of inflammation. Therefore, we determined if this pathway is dysregulated in psoriasis, and how this affects immune cell activity.MethodsHuman skin biopsies were examined by quantitative polymerase chain reaction, flow cytometry, and immunohistochemistry. The role of CD200R1 in regulating psoriasis‐like skin inflammation was examined using CD200R1 blocking antibodies in mouse psoriasis models. CD200R1 blocking antibodies were also used in an in vivo neutrophil recruitment assay and in vitro assays to examine macrophage, innate lymphoid cell, γδ T cell, and neutrophil activity.ResultsWe reveal that CD200 and signaling via CD200R1 are reduced in non‐lesional psoriasis skin. In mouse models of psoriasis CD200R1 was shown to limit psoriasis‐like inflammation by enhancing acanthosis, CCL20 production and neutrophil recruitment, but surprisingly, macrophage function and IL‐17 production were not affected, and neutrophil reactive oxygen species production was reduced.ConclusionCollectively, these data show that CD200R1 affects neutrophil function and limits inflammatory responses in healthy skin by restricting neutrophil recruitment. However, the CD200 pathway is reduced in psoriasis, resulting in a loss of immune control, and increased neutrophil recruitment in mouse models. In conclusion, we highlight CD200R1:CD200 as a pathway that might be targeted to dampen inflammation in patients with psoriasis.
Leptomeningeal metastases in patients with human epidermal growth factor receptor 2 positive breast cancer: Real‐world data from a multicentric European cohort
Authors: Ratosa Ivica , Dobnikar Nika , Bottosso Michele , Dieci Maria Vittoria , Jacot William , Pouderoux Stéphane , Ribnikar Domen , Sinoquet Léa , Guarneri Valentina , Znidaric Tanja , Darlix Amélie , Griguolo Gaia 
Published: June 2022

AbstractIn patients with human epidermal growth factor receptor 2 positive (HER2+) breast cancer, leptomeningeal metastases (LM) are a rare but often a fatal clinical scenario. In this multicentric study, clinical and pathologic characteristics of patients with HER2+ breast cancer developing LM were described, as well as survival outcomes. Data were gathered retrospectively from medical records of 82 patients with advanced HER2+ breast cancer and LM treated between August 2005 and July 2020. Following LM diagnosis, 79 (96.3%) patients received at least one line of anti‐HER2 therapy, 25 (30.5%) patients received intrathecal therapy and 58 (70.7%) patients received radiotherapy. Overall survival (OS) was 8.3 months (95% confidence interval [CI] 5.7‐11), 1‐year OS was 42%, and 2‐year OS was 21%. At univariate analysis, patients who were treated after 2010, had better Karnofsky performance status, were free of neurological symptoms, had better prognostic, received chemotherapy (OS difference 9.4 months, P = .024), or monoclonal antibodies (trastuzumab ± pertuzumab; OS difference 6.1 months; P = .013) after LM diagnosis, had a statistically significantly longer OS. Presence of neurological symptoms (hazard ratio 3.32, 95% CI 1.26‐8.73; P = .015) and not having received radiotherapy (hazard ratio 2.02, 95% CI 1.09‐3.72; P = .024) were all associated with poorer OS at multivariate analysis. To summarize, not having neurological symptoms and receiving RT at LM diagnosis were associated with prolonged OS in our cohort. Survival seemed to be prolonged with multimodality treatment, which included targeted therapy, chemotherapy, and RT to the LM sites.
Ciliary membrane, localised lipid modification and cilia function
Authors: Dutta Priya , Ray Krishanu 
Published: June 2022

AbstractCilium, a tiny microtubule‐based cellular appendage critical for cell signalling and physiology, displays a large variety of receptors. The composition and turnover of ciliary lipids and receptors determine cell behaviour. Due to the exclusion of ribosomal machinery and limited membrane area, a cilium needs adaptive logistics to actively reconstitute the lipid and receptor compositions during development and differentiation. How is this dynamicity generated? Here, we examine whether, along with the Intraflagellar‐Transport, targeted changes in sector‐wise lipid composition could control the receptor localisation and functions in the cilia. We discuss how an interplay between ciliary lipid composition, localised lipid modification, and receptor function could contribute to cilia growth and signalling. We argue that lipid modification at the cell‐cilium interface could generate an added thrust for a selective exchange of membrane lipids and the transmembrane and membrane‐associated proteins.
Decreased haemoglobin levels are associated with lower muscle mass and strength in kidney transplant recipients
Authors: Vinke Joanna Sophia J. , Wouters Hanneke J.C.M. , Stam Suzanne P. , Douwes Rianne M. , Post Adrian , Gomes‐Neto Antonio W. , van der Klauw Melanie M. , Berger Stefan P. , Bakker Stephan J.L. ,   TransplantLines Investigators, De Borst Martin H. , Eisenga Michele F. 
Published: June 2022

AbstractBackgroundPost‐transplant anaemia and reduced muscle mass and strength are highly prevalent in kidney transplant recipients (KTRs). Decreased haemoglobin levels, a marker of anaemia, could adversely affect muscle mass and strength through multiple mechanisms, among others, through diminished tissue oxygenation. We aimed to investigate the association between haemoglobin levels with muscle mass and strength in KTRs.MethodsWe included stable KTRs from the TransplantLines Biobank and Cohort study with a functional graft ≥1 year post‐transplantation. Muscle mass was assessed using 24 h urinary creatinine excretion rate (CER) and bioelectrical impedance analysis (BIA). Muscle strength was assessed with a handgrip strength test using a dynamometer and, in a subgroup (n = 290), with the five‐times sit‐to‐stand (FTSTS) test. We used multivariable linear and logistic regression analyses to investigate the associations of haemoglobin levels with muscle mass and strength.ResultsIn 871 included KTRs [median age 58 (interquartile range (IQR), 48–66)] years; 60% men; eGFR 51 ± 18 mL/min/1.73 m2) who were 3.5 (1.0–10.2) years post‐transplantation, the mean serum haemoglobin level was 13.9 ± 1.8 g/dL in men and 12.8 ± 1.5 g/dL in women. Lower haemoglobin levels were independently associated with a lower CER (std. β = 0.07, P = 0.01), BIA‐derived skeletal muscle mass (std. β = 0.22, P < 0.001), handgrip strength (std. β = 0.15, P < 0.001), and worse FTSTS test scores (std. β = −0.17, P = 0.02). KTRs in the lowest age‐specific and sex‐specific quartile of haemoglobin levels had an increased risk of being in the worst age‐specific and sex‐specific quartile of CER (fully adjusted OR, 2.09; 95% CI 1.15–3.77; P = 0.02), handgrip strength (fully adjusted OR, 3.30; 95% CI 1.95–5.59; P < 0.001), and FTSTS test score (fully adjusted OR, 7.21; 95% CI 2.59–20.05; P < 0.001).ConclusionsLow haemoglobin levels are strongly associated with decreased muscle mass and strength in KTRs. Future investigation will need to investigate whether maintaining higher haemoglobin levels may improve muscle mass and strength in KTRs.
Graphene‐wrapped TiO2 composites as advanced anode materials for high electrochemical performance Li‐ion batteries
Authors: Wang Hongliang , Zhang Pengchao , Huang Pengfei 
Published: June 2022

AbstractBackgroundDeveloping new anode materials with high specific capacity for high‐performance lithium (Li)‐ion batteries is significant for meeting high energy density demand. Composites of graphene‐wrapped titania (TiO2) nanoparticles (GTO) have been successfully synthesized via a facile method for anode material in Li‐ion batteries.ResultsThe as‐prepared GTO composites exhibit remarkable electrochemical performance, including initial high specific capacity of 652.8 mAh g−1 and outstanding cycling stability (198 mAh g−1 after 300 cycles).ConclusionsThe outstanding performance is due to the positive effect of graphene, which acts both as electron conductor and volume buffer layer. This work further demonstrates that GTO composites could acts as a stable anode for reversible Li‐ion batteries. © 2022 Society of Chemical Industry (SCI).
Preliminary study of the ameliorative effects of melatonin on cadmium‐induced morphological and biochemical alterations in the rat Harderian gland
Authors: Romano Maria Zelinda , Aniello Francesco , Venditti Massimo , Minucci Sergio 
Published: June 2022

AbstractHerein is reported, for the first time in the rat Harderian gland (HG), the counteractive action of melatonin (Mlt), a well‐known antioxidant radical scavenger, on the increased oxidative stress damages induced by a pro‐oxidant substance, cadmium (Cd), an environmental pollutant also considered as endocrine disruptor. HG, an infraorbital gland present in almost all terrestrial vertebrates, produces a lipid secretion to lubricate the eyeball, as well as porphyrin/Mlt as light transducers. Moreover, HG is an extra‐gonadal source of steroid sex hormones. Via ex vivo experiments lasting for 24 h, we verified the increased lipid peroxidation in Cd‐treated glands, producing morphological alteration of the glandular epithelium, as well as an increased porphyrins accumulation. Moreover, Cd also induced a decreased protein level of the steroidogenic enzymes steroidogenic acute regulatory (StAR) and 3βHSD, and an increased mast cell number. Results obtained with Mlt cotreatment demonstrated that it decreased the levels of Cd‐induced oxidative damage, with reversal of all the observed modification. Furthermore, the TUNEL assay showed that the increased number of apoptotic cells in Cd‐treated HG was counteracted by the contemporaneous Mlt administration. Results confirmed that Mlt treatment restored the levels of two autophagy markers, LC3 and p62, counteracting the autophagy Cd‐induced. Interestingly, the positive effects of Mlt alone were highlighted by the decreased rate of lipid peroxidation as compared with the control, confirming its antioxidant action. Combined data further confirmed the antioxidant action of Mlt in counteracting the degeneration provoked by reactive oxygen species (ROS) in the rat HG, a tissue extremely susceptible to oxidative stress condition.
The effect of protease inhibitors‐based antiretroviral therapy on serum/plasma interleukin‐6 levels among PLHIV: a systematic review and meta‐analysis
Authors: Ashuro Akililu Alemu , Zhang Si‐Chen , Wang Ting , Chu Qin‐Shu , Fu Yuan‐Sheng , Fan Yin‐Guang , Ye Dong‐Qing 
Published: June 2022

AbstractRecommended treatment regimen for human immune deficiency virus (HIV) infection includes protease inhibitors/ritonavir (PIs/r) combined with two‐nucleoside reverse‐transcriptase inhibitors (2NRTIs), which enable to achieve and maintain viral suppression, restore, and preserve immune function. However, there were inconsistent findings on the levels of interleukin‐6 (IL‐6) levels. Systematic review and meta‐analysis were performed to quantify the pooled effects of PIs/r‐based antiretroviral therapy (ART) on serum/plasma IL‐6 levels in people living with the HIV (PLHIV). PubMed, Web of Science, and Embase were searched from the earliest record to November 4, 2020. Data analysis was conducted on Stata version 16 and Review Manager 5.3. A random‐effect model was used to compute a pooled effect size and weighted mean difference (WMD) was considered the summary effect size. Heterogeneity between studies was estimated by Cochrane's Q test (χ2 test) and I2 statistic and subgroup analysis were performed to explore the source of heterogeneity. Initial search identified 3098 records and 5 studies (7 trials) met inclusion criteria. The pooled mean difference in serum/plasma IL‐6 levels from baseline to follow‐up was 0.534 pg/ml (95% confidence interval: −0.012, 1.08, P = 0.05, I2 = 76.4%). In subgroup analysis, there was a significant association between increased serum/plasma IL‐6 levels and age group ≥ 35 years old, baseline CD4+ counts < 350 cell/mm3, and mean viral load ≥ 4.5 log10 copies/ml. We found that serum/plasma IL‐6 levels increased after combined ART among treatment‐naïve individuals who initiated a successful combination of PIs/r with 2NRTIs. This result also highlights the need to monitor serum/plasma IL‐6 levels during antiviral therapy, which may aid in the effective future treatment of systemic inflammation and related disorders following elevated IL‐6 levels.
Omni‐channel retailing on platforms: Disentangling the effects of channel integration and inter‐platform function usage difference
Authors: Fang Jie , Liu Hefu , Cai Zhao , Tan Chee‐Wee 
Published: June 2022

AbstractThe rise of omni‐channel retailing poses challenges for e‐marketplace platforms. To retain third‐party sellers in the face of competitive pressure from rivals, e‐marketplace platforms are compelled to provide support for online‐offline channel integration (OOCI). However, the provision of OOCI support can adversely affect an OOCI‐enabled platform's product sales growth by encouraging consumers to switch to brick‐and‐mortar stores operated by third‐party sellers. To ascertain how the OOCI‐enabled platform can outperform under such circumstances, we analyzed data on sales of 51,409 products on a dominant Chinese e‐marketplace platform as well as inter‐platform function usage difference across 209 third‐party sellers. Combining propensity score matching with hierarchical linear modeling, we discovered that informational OOCI (e.g., concurrent availability of a product on both online and offline channels) negatively influences the OOCI‐enabled platform's product sales growth, whereas the effect of physical OOCI (e.g., the option of store pickup for online purchases) is not significant. Additionally, we found that the three constituent sub‐dimensions of third‐party sellers' inter‐platform function usage difference (i.e., volume difference, category orientation specialization, and uniqueness) moderate the impact of OOCI on the OOCI‐enabled platform's product sales growth differently. Findings from this study thus yield actionable guidelines for e‐marketplace platforms pursuing omni‐channel retailing strategies.
Cardiac tumors—sex‐related characteristics and outcomes after surgical resection
Authors: Gaisendrees Christopher , Gerfer Stephen , Schlachtenberger Georg , Walter Sebastian G. , Ivanov Borko , Merkle‐Storms Julia , Mihaylova Mariya , Sabashnikov Anton , Djordjevic Ilija , Rahmanian Parwis , Mader Navid , Kuhn‐Régnier Ferdinand , Wahlers Thorsten 
Published: June 2022

AbstractObjectivesCardiac tumors represent a rare and heterogeneous pathological entity, with a cumulative incidence of up to 0.02%. Gender was previously reported to influence outcomes after tumor surgery. This study aimed to investigate for gender‐related differences in outcomes after cardiac surgery.MethodsBetween 2009 and 2021, 95 male and 88 female patients underwent surgery for tumor extirpation in our center. Preoperative baseline characteristics, intraoperative data, and long‐term survival were analyzed. The diagnosis was confirmed postoperatively by (immune‐)histopathological analysis.ResultsThere were no significant differences in baseline characteristics and survival. Myxoma was the most common tumor type overall and was more diagnosed in women (n = 36 vs. n = 62, p ≤ 0.001). Sarcoma was the most common malignant tumor type (n = 5). Tumor location at the atrial septum was more likely in women (n = 26 vs. n = 16, p = 0.041), whereas ventricular localization was more common in male patients (n = 20 vs. n = 7, p = 0.001). Minimally invasive tumor extirpation was significantly more often performed in women, and in‐hospital stay was shorter in female patients.ConclusionThe localization and dignity of cardiac tumors differ between genders, not affecting survival. Surgical tumor extirpation remains the gold standard of treatment for cardiac tumors in both genders as it is highly effective and associated with good long‐term survivorship.