bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of some immunological parameters in hematological malignancies patients
Authors: Kadhem Raghad Ridha , Kareem Hiyame Abdel Ridha , Jahil Karrar Abd Ali 
Published: June 2022

This study aimed to verify the number of differentiation aggregates that include HLA-DR, CD5 and CD7 In patients with hematological malignancies and comparing them with the healthy group, where the levels of these subgroups were detected in the peripheral blood of 40 males and females, Where samples were collected by 20 samples from patients with malignant hematomas, Plus 20 people from the healthy group.All blood samples and available data were collected from patients with hematological malignancies, from the Center for Oncology and Hematology,in partnership with the laboratories of medical centers and Al-Jawadeen National Laboratory, for the period from November 2021 to May 2022.The immunophenotypes of HLA-DR, CD5 and CD7 were studied in the samples using the flow cytometry technique,where the rate of differentiation aggregates in patients with leukemia was much higher than in healthy people, where the results showed significant differences with statistical significance at the level of P≤ 0.05 in the proportion of CD5, CD7 and HLA-DR in samples of patients with hematological malignant diseases, and a slight increase in the level of CD5 and HLA-DR was found in males than in females, and a slight decrease in the level of CD7 was observed in males than in females.
Effect of JPMR on State-Trait Anxiety among young female adult during COVID-19 pandemic lockdown
Authors: Sudheer Vani , Naachimuthu K P 
Published: June 2022

The worldwide pandemic situation that is caused by coronavirus disease 2019 (COVID-19) has led the population to a state of confinement, which has created a rise in state trait anxiety among people around us. COVID-19 affected our psychological state similarly as our physical health. The research design used in this study is quasi experimental research design and the questionnaire used was State Trait Anxiety Inventory (STAI Form Y-1 & Y-2 Charles D. Spielberger, 1983). Study includes 30 young female adult and out of that 15 subjects were taken into account as experimental group and were given the JPMR as the intervention plan for one month. The objective of our study is to find the effectiveness of JPMR on state trait anxiety. After the intervention data was analysed using paired t-test and correlation. Although result proved that for state anxiety obtained P value is 0.000 which is significant at 0.01 level (t =7.08, p=0.000) indicating that JPMR therapy was effective in reducing the state anxiety for the experimental group. No significant difference found in trait anxiety in both experimental and control group.
Uji Kualitas Sabun Padat Transparan Dari Minyak Kelapa Dan Minyak Kelapa Sawit Dengan Antioksidan Ekstrak Likopen Buah Tomat
Authors: Fanani Zainal , Panagan Almunady T. , Apriyani Novita 
Published: June 2022

Increasing population growth causes demand for daily necessities to increase as well, one of which is soap, because almost all humans use soap to wash and clean themselves. The purpose of this reseacrh was to determine the optimum ratio of coconut oil and palm oil to produce the best transparent solid soap and tomato lycopene extract added to maximize the benefits of the soap. Characterization includes water content, total fat, insoluble material in ethanol, free alkali, free fatty acids, non-soaped fats, pH, foam stability, and antioxidant activity from lycopene. The best result was soap with ratio of coconut oil and palm oil 1: 0. The resulting soap has a high transparency, smooth foam, water content of 3.546%, foam stability of 96%, and pH of 10. Soap accordance with SNI3532-2016, except the unsaponifiables fat. The analysis results obtained water content of 3.486%, total fat of 73.616%, insoluble material in ethanol of 1.2%, free fatty acid of 0.564%, negative free alkali, unsaponifiables fat of 0.7294% and Lycopene antioxidant activity of 54.85 µg/mL.
Conflictos de uso de tierra en la microcuenca Cocheros Tingo María, 2022
Authors: Oré Cierto Luis Eduardo , Machuca Geyson Andrade , Rengifo Trigozo Juan Pablo , Loarte Aliaga Wendy Caroline , Oré Cierto Juan Daniel 
Published: June 2022

El estudio se llevó a cabo en la cuenca Cocheros, del distrito de Rupa Rupa, provincia de Leoncio Prado del departamento de Huánuco con el propósito de determinar los conflictos de uso en la cuenca cocheros. La metodología consistió en elaborar los mapas temáticos cuya información nos facilite la obtención del mapa de capacidad de uso mayor de tierras tomando como referencia el reglamento de capacidad de uso mayor de tierras. Las unidades de uso actual se establecieron a través de la clasificación supervisada con puntos control y su clasificación fue de acuerdo al sistema de clasificación de Unión Geográfica Internacional (UGI) adecuado para la zona de estudio. Los conflictos de uso tierra se estableció superponiendo los mapas de C.U.M y U.AT, tomando en cuenta los tres niveles como el uso correcto, subuso y sobreuso.
La capacidad de uso mayor de tierras comprende tierras aptas para: cultivo en limpio con calidad agrologica baja y con limitaciones por suelo (A3s) con 80.71 has, en producción forestal se encontró dos clases una de calidad agrológica media y con limitaciones por microrelieve y suelo (F2es) con 26.32 has y otra con calidad agrologica baja y con limitaciones por microrelieve y suelo (F3es) con 262.44 has y tierras de protección (X) con 86.4 has.
Countering corruption as a threat to public security in foreign countries
Authors: Filatova Elena Vital'evna 
Published: June 2022

Among the factors that pose a systemic threat to public security in modern realities, one of the most important is the spread of corruption. At the same time, many of the foreign countries have faced manifestations of this threat much earlier than the Russian Federation, and therefore have accumulated more substantial experience in countering them. In this context, the article examines the specifics of the implementation of various anti-corruption models that take place in world practice (Singapore, the United States of America, Ireland, etc.). It also substantiates the most important role of the public control system in the system of leveling threats to public security generated by corruption factors. In the context of the topic under consideration, it seems necessary to legislatively regulate the order of interaction of public control institutions with state and municipal bodies, as well as the responsibility of the latter for non-assistance or opposition to structures empowered to carry out public anti-corruption control.Summing up the analysis, I would like to note that the use of foreign experience of administrative and legal regulation both in the field of formation of mechanisms of public (public) anti-corruption control and improvement of anti-corruption mechanisms in general is one of the most important areas of ensuring public safety due to the extremely high danger posed by modern trends in the development of corruption processes for the formation of the environment, characteristic of a healthy society.
Outer synchronization for a class of discrete‐time complex dynamic networks with unknown bounded interaction
Authors: Lu Jiawei , Wang Yinhe , Li Shengping 
Published: June 2022

SummaryThis article investigates the outer synchronization for the two discrete‐time complex dynamic networks. First, the more universal mathematical models of the networks with unknown coupling and interaction are proposed. Then, based on the available state of networks and the estimation of summarized unknown parameters shown in the models, the adaptive state feedback controller is synthesized to make the outer synchronization error of two networks converge asymptotically to an arbitrarily small neighborhood at the origin. Finally, the results of simulation show the validity and advantages of the controller.
Printable and Stretchable Conductive Elastomers for Monitoring Dynamic Strain with High Fidelity
Authors: Yuan Jinfeng , Zhang Yuzhong , Li Guozhen , Liu Shiqiang , Zhu Rong 
Published: June 2022

AbstractPrintable and stretchable conductive elastomers have promising applications for epidermal and wearable electronics, soft robotics, etc. However, these conductive materials usually present poor performances in monitoring dynamic strains. The monitored signals are distorted and lose key physical signs, which limit their practical applications. Through investigating kinetic behaviors of conductive pathways along longitudinal and transverse directions in these conductive materials, the physical mechanism of signal distortion under dynamic strains is interpreted. To overcome this strain sensing problem, an Ag‐Ecoflex‐polydimethylsiloxane (PDMS) elastomer by printing Ag‐filler‐Ecoflex‐matrix ink on PDMS is proposed. Compared to other conductive materials, the Ag‐Ecoflex‐PDMS elastomer has preferable dynamic performances, embodying smaller overshoot response, higher strain sensitivity, and lower hysteresis. A deep‐learning‐based dynamic calibration method is proposed to successfully correct the sensing signals and eliminate the hysteresis error to 0.1%. Moreover, the proposed Ag‐Ecoflex‐PDMS elastomers gain high electrical conductivities owing to thermal expansion and contraction of PDMS substrate during the thermosetting of conductive ink, and thus can be both excellent stretchable sensors and stretchable conductors. Demonstrations of monitoring knee motion with high fidelity and human–robot collaborative playing ping‐pong validate superior accuracy and robustness of the Ag‐Ecoflex‐PDMS elastomers for monitoring human dynamic activities, human‐machine collaboration, virtual reality, etc.
Recent Advances of Three‐component Reactions of Simple Indoles
Authors: Wang Zhan‐Yong , Liu Zhantong , Sun Aili , Wang Kai‐Kai 
Published: June 2022

AbstractIndoles are extremely important and versatile building blocks in the field of chemistry. This review highlights the advance made in the three‐component reactions of indoles between 2011–2021. The reaction types are classified into three categories based on the trigger mechanisms. Reactions with alkenes, alkynes, aldehydes, imines, ketones, S, Se, etc are discussed. In order to highlight the mechanisms involved, this review has provided specific analysis inside a gray box in each scheme. We hope these studies will promote future research in the indole area.
Cardiometabolic multimorbidity accelerates cognitive decline and dementia progression
Authors: Dove Abigail , Marseglia Anna , Shang Ying , Grande Giulia , Vetrano Davide Liborio , Laukka Erika J , Fratiglioni Laura , Xu Weili 
Published: June 2022

AbstractIntroductionCardiometabolic diseases (CMDs) have been individually associated with adverse cognitive outcomes, but their combined effect has not been investigated.MethodsA total of 2577 dementia‐free participants 60 years of age or older were followed for 12 years to observe changes in cognitive function and to detect incident cognitive impairment, no dementia (CIND) and dementia. CMDs (including type 2 diabetes, heart disease, and stroke) were assessed at baseline through medical records and clinical examinations. Cardiometabolic multimorbidity was defined as the presence of two or more CMDs. Data were analyzed using multi‐adjusted linear mixed‐effects models, Cox regression, and Laplace regression.ResultsCMD multimorbidity was associated with cognitive decline, CIND (hazard ratio [HR] 1.73; 95% confidence interval CI 1.23 to 2.44), and its progression to dementia (HR 1.86; 95% CI 1.17 to 2.97). CMD multimorbidity accelerated the onset of CIND by 2.3 years and dementia by 1.8 years.ConclusionsCMD multimorbidity accelerates cognitive decline and increases the risk of both CIND and its conversion to dementia.Highlights
We explored the combined impact of cardiometabolic diseases (CMDs) on cognition.
An increasing number of CMDs dose‐dependently accelerated cognitive decline.
CMD multimorbidity increased the risk of both cognitive impairment and dementia.
Co‐morbid CMDs could be ideal targets for interventions to protect cognitive health.
The Latin American Brain Health Institute, a regional initiative to reduce the scale and impact of dementia
Authors: Duran‐Aniotz Claudia , Sanhueza Jorge , Grinberg Lea T. , Slachevsky Andrea , Valcour Victor , Robertson Ian , Lawlor Brian , Miller Bruce , Ibáñez Agustín 
Published: June 2022

AbstractLatin American and Caribbean countries face complex challenges to improve brain health and reduce the impact of dementia. Regional hubs devoted to research, capacity building, implementation science, and education are critically needed. The Latin American Brain Health Institute represent an important step to address many of these needs.
Circularly Polarized Luminescence Active Supramolecular Nanotubes Based on PtIIComplexes That Undergo Dynamic Morphological Transformation and Helicity Inversion
Authors: Kang Seok Gyu , Kim Ka Young , Cho Yumi , Jeong Dong Yeun , Lee Ji Ha , Nishimura Tomoki , Lee Shim Sung , Kwak Sang Kyu , You Youngmin , Jung Jong Hwa 
Published: June 2022

AbstractCircularly polarized luminescence (CPL) with tunable chirality is currently a challenging issue in the development of supramolecular nanomaterials. We herein report the formation of helical nanoribbons which grow into helical tubes through dynamic helicity inversion. For this, chiral PtIIcomplexes of terpyridine derivatives, namelyS‐trans‐1andR‐trans‐1, with respectiveS‐ andR‐alanine subunits and incorporatingtrans‐double bonds in the alkyl chain were prepared. In DMSO/H2O (5 : 1v/v),S‐trans‐1initially forms a fibrous self‐assembled product, which then undergoes dynamic transformation into helical tubes (left‐handed orM‐type) through helical ribbons (right‐handed orP‐type). Interestingly, both helical supramolecular architectures are capable of emitting CPL signals. The metastable helical ribbons show CPL signals (glum=±4.7×10−2) at 570 nm. Meanwhile, the nanotubes, which are the thermodynamic products, show intense CPL signals (glum=±5.6×10−2) at 610 nm accompanied by helicity inversion. This study provides an efficient way to develop highly dissymmetric CPL nanomaterials by regulating the morphology of metallosupramolecular architectures.
Development of high‐flux aciduric ultra‐thin nanofibrous pervaporation composite membrane for acetic acid dehydration
Authors: Li Peiyun , Zhang Tonghui , Ding Siping , Wang Xuefen 
Published: June 2022

AbstractAcetic acid is an essential intermediate chemical in industry. Traditional inorganic membrane cannot meet the demand of high‐efficient dehydration and polymeric membrane is restricted by its low organic solution resistance. In this work, a novel aciduric pervaporation composite membrane was successfully generated by fabricating an ultrathin polysulfonamide (PSA) layer on the polyacrylonitrile (PAN) nanofibrous substrate via interfacial polymerization (IP) method. Through the optimization of fabrication process including selecting the suitable structure of diamine (taking three types aliphatic amines as candidates), optimizing the concentration of two phase solutions, the resultant thin‐film nanofibrous composite (TFNC) membrane was fabricated by using aliphatic amine triethylenetetramine (TETA: 3.0 wt%) and 1, 3‐benzenedisulfonyl chloride (BDSC: 1.0 wt%) as IP monomers and the network structure with suitable sieving size was constructed. The ultrathin aciduric PSA selective layer (thickness: 104 ± 15 nm) endowed the TFNC membrane with excellent separation efficiency. For dehydrating 70 wt% acetic acid aqueous solution at 60°C, PSA‐3.0‐1.0/PAN TFNC membrane exhibited competitive separation efficiency and great acid stability. It possessed extremely high permeate flux (15,321 g/m2 h) with stable separation factor (109). For long‐term acid dehydration evaluation, PSA/PAN membrane showed great stability during 7 days pervaporation. This work took advantage of traditional IP method for designing a novel pervaporation membrane with aciduric chemical structure, suggested an effective and facile approach to develop novel pervaporation membranes for harsh environment separation.
Decellularized adipose tissue matrix‐coated and simvastatin‐loaded hydroxyapatite microspheres for bone regeneration
Authors: Kesim Merve G. , Durucan Caner , Atila Deniz , Keskin Dilek , Tezcaner Ayşen 
Published: June 2022

AbstractSimvastatin (SIM)‐loaded and human decellularized adipose tissue (DAT)‐coated porous hydroxyapatite (HAp) microspheres were developed for the first time to investigate their potential on bone regeneration. Microspheres were loaded with SIM and then coated with DAT for modifying SIM release and improving their biological response. HAp microspheres were prepared by water‐in‐oil emulsion method using camphene (C10H16) as porogen followed by camphene removal by freeze‐drying and sintering at 1200°C for 3 h. Sintered HAp microspheres with an average particle size of ~400 µm were porous and spherical in shape. Microspheres were incubated with 1, 2.5, and 5 mg/ml SIM stock solutions for drug loading, and drug loading was determined as 7.5 ± 0.79, 20.41 ± 1.93, and 46.26 ± 0.29 µg SIM/mg microspheres, respectively. SIM loading increased with the increase of the initial SIM loading amount. Faster SIM release was observed in DAT‐coated microspheres compared to bare counterparts. Higher SaoS‐2 cell attachment and proliferation were observed on DAT‐coated microspheres. Significantly higher alkaline phosphatase activity of SaoS‐2 cells was observed on DAT‐coated microspheres containing 0.01 mg/ml SIM than all other groups (p < 0.01). DAT‐coated microspheres loaded with SIM at low doses hold promise for bone tissue engineering applications.
Designing bacterial consortia for the complete biodegradation of insensitive munitions compounds in waste streams
Authors: Menezes Osmar , Owens Cameron , Rios‐Valenciana Erika E. , Sierra‐Alvarez Reyes , Field Jim A. , Spain Jim C. 
Published: June 2022

AbstractInsensitive munitions compounds (IMCs), such as 2,4‐dinitroanisole (DNAN) and 3‐nitro‐1,2,4‐triazol‐5‐one (NTO), are replacing conventional explosives in munitions formulations. Manufacture and use of IMCs generate waste streams in manufacturing plants and load/assemble/pack facilities. There is a lack of practical experience in executing biodegradation strategies to treat IMCs waste streams. This study establishes a proof‐of‐concept that bacterial consortia can be designed to mineralize IMCs and co‐occurring nitroaromatics in waste streams. First, DNAN, 4‐nitroanisole (4‐NA), and 4‐chloronitrobenzene (4‐CNB) in a synthetic DNAN‐manufacturing waste stream were biodegraded using an aerobic fluidized‐bed reactor (FBR) inoculated with Nocardioides sp. JS 1661 (DNAN degrader), Rhodococcus sp. JS 3073 (4‐NA degrader), and Comamonadaceae sp. LW1 (4‐CNB degrader). No biodegradation was detected when the FBR was operated under anoxic conditions. Second, DNAN and NTO were biodegraded in a synthetic load/assemble/pack waste stream during a sequential treatment comprising: (i) aerobic DNAN biodegradation in the FBR; (ii) anaerobic NTO biotransformation to 3‐amino‐1,2,4‐triazol‐5‐one (ATO) by an NTO‐respiring enrichment; and (iii) aerobic ATO mineralization by an ATO‐oxidizing enrichment. Complete biodegradation relied on switching redox conditions. The results provide the basis for designing consortia to treat mixtures of IMCs and related waste products by incorporating microbes with the required catabolic capabilities.
Cover picture: Investigation into the morphological implications on electron transfer dynamics of lithium peroxides by scanning electrochemical microscopy (BKCS 06/2022)
Authors: Hyun Ryu C. , Ahn Hyun S. 
Published: June 2022

Elucidation of the morphology‐dependent electron transfer rate was empirically demonstrated by scanning electrochemical microscopy investigation of lithium peroxide species, an important intermediate in the lithium‐air battery cycles. This communication revealed distinct electron transfer coefficients for the toroidal and thin‐film lithium peroxidespecies. This discovery deepens the understanding of battery cycling mechanism and holds the key to unlocking the reversibility of lithium‐air batteries.
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The establishment of polypeptide PSMA‐targeted chimeric antigen receptor‐engineered natural killer cells for castration‐resistant prostate cancer and the induction of ferroptosis‐related cell death
Authors: Wu Liyuan , Liu Fei , Yin Le , Wang Fangming , Shi Hui , Zhao Qinxin , Yang Feiya , Chen Dong , Dong Xiying , Gu Yuchun , Xing Nianzeng 
Published: June 2022

AbstractBackgroundThe mortality of castration‐resistant prostate cancer (CRPC) is high due to lack of an effective treatment. Chimeric antigen receptor (CAR)‐based therapy is a promising immunotherapeutic strategy. Here, we aimed to design a novel CAR‐natural killer (NK) cells with a clinically significant tumoricidal effect on CRPC.MethodsWe constructed novel CAR‐NK92MI cells with a CD244‐based recombinant lentiviral vector. Different intracellular segments (CD244, NKG2D, or CD3ζ) were screened to identify the best candidate according to cell lysis assay and CD107a expression levels. To enhance the affinity of the CAR to the tumor antigen, we compared an antibody specific for prostate‐specific membrane antigen (anti‐PSMA) with PSMA‐targeted polypeptide (p‐PSMA), which was screened by phage display combinatorial library. Then, CAR‐NK92MI cells with both a high affinity for PSMA and a strong tumoricidal capacity were generated. In addition, we verified their tumor‐killing effect in vitro and in vivo. The release of cytokine by NK92MI cells was compared with that by CAR‐NK92MI cells through flow cytometry and enzyme‐linked immunosorbent assay. Moreover, ferroptosis‐related cell death was explored as a possible underlying mechanism.ResultsThree different CAR intracellular regions CAR1 (CD244), CAR2 (CD244, NKG2D) and CAR3 (CD244, NKG2D, and CD3ζ) were constructed. CAR2 was chosen to confer a stronger tumoricidal ability on CAR‐NK92MI cells. Compared with anti‐PSMA, p‐PSMA exhibited enhanced affinity for the tumor antigen. Thus, p‐PSMA‐CAR‐NK92MI cells, which expressed CAR with a polypeptide‐based antigen‐binding region, an intracellular CD244 and a NKG2D costimulatory domain, were generated. They could selectively and successfully kill PSMA+ target cells and exhibited specific lysis rate of 73.19% for PSMA‐positive C4‐2 cells and 33.04% for PSMA‐negative PC3 cells. Additionally, p‐PSMA‐CAR‐NK92MI cells had significantly higher concentrations of IFN‐γ, TNF‐α and granzyme B than NK92MI cells. In a CRPC cancer xenograft model, p‐PSMA‐CAR‐NK92MI cells significantly inhibited tumor growth and exerted a more consistent killing effect than NK92MI cells. Moreover, ferroptosis is a potential mechanism through which CAR‐NK92MI cells attack cancer cells, and is triggered by IFN‐γ.Conclusionsp‐PSMA‐CAR‐NK92MI cells can effectively kill CRPCPSMA+ cells in vitro and in vivo. This strategy may provide additional treatment options for patients with CRPC.
Pyrone Derivatives from a Mangrove Endophytic Fungus Phomopsis asparagi LSLYZ‐87
Authors: Liu Yayue , Yang Wencong , Liao Qingnan , She Zhigang 
Published: June 2022

AbstractChemical investigation of the endophytic fungus Phomopsis asparagi LSLYZ‐87 cultured on PDB medium led to the isolation of two new pyrone derivatives, phomasparapyrone A (1), and phomasparapyrone B (2), together with the known kojic acid (3). Their planar structures were connected through 1D and 2D NMR spectroscopic data. And the stereo structures of 1 and 2 were defined by comparison of the experimental ECD spectra to calculated one. All isolates were evaluated for their anti‐neuroinflammatory activities. Among them, compound 2 showed moderate inhibition on NO accumulation induced by LPS on BV‐2 cells in a dose dependent manner at 30, 40 and 50 μM, and without cytotoxicity in a concentration of 50.0 μM.