bluuebunny/crossref_metadata_2025_split huggingface dataset:
Normal Appearing Ischaemic Brain Tissue on CT and Outcome After Intravenous Alteplase
Authors: Mair Grant , Wardlaw Joanna M. 
Published: June 2022

Background and AimsThe visibility of ischaemic brain lesions on non-enhanced CT increases with time. Obviously hypoattenuating lesions likely represent infarction. Conversely, viable ischaemic brain lesions may be non-visible on CT. We tested whether patients with normal appearing ischaemic brain tissue (NAIBT) on their initial CT are identifiable, and if NAIBT yields better outcomes with alteplase.MethodsWith data from the Third International Stroke Trial (IST-3, a large randomized-controlled trial of intravenous alteplase for ischaemic stroke) we used receiver-operating characteristic analysis to find a baseline National Institutes of Health Stroke Scale (NIHSS) threshold for identifying patients who developed medium-large ischaemic lesions within 48 h. From patients with baseline CT (acquired &lt;6 h from stroke onset), we used this NIHSS threshold for selection and tested whether favorable outcome after alteplase (6-month Oxford Handicap Score 0–2) differed between patients with NAIBT vs. with those with visible lesions on baseline CT using binary logistic regression (controlled for age, NIHSS, time from stroke onset to CT).ResultsFrom 2,961 patients (median age 81 years, median 2.6 h from stroke onset, 1,534 [51.8%] female, 1,484 [50.1%] allocated alteplase), NIHSS&gt;11 best identified those with medium-large ischaemic lesions (area under curve = 0.79, sensitivity = 72.3%, specificity = 71.9%). In IST-3, 1,404/2,961 (47.4%) patients had baseline CT and NIHSS&gt;11. Of these, 745/1,404 (53.1%) had visible baseline ischaemic lesions, 659/1,404 (46.9%) did not (NAIBT). Adjusted odds ratio for favorable outcome after alteplase was 1.54 (95% confidence interval, 1.01–2.36), p = 0.045 among patients with NAIBT vs. 1.61 (0.97–2.67), p = 0.066 for patients with visible lesions, with no evidence of an alteplase-NAIBT interaction (p-value = 0.895).ConclusionsPatients with ischaemic stroke and NIHSS &gt;11 commonly develop sizeable ischaemic brain lesions by 48 h that may not be visible within 6 h of stroke onset. Invisible ischaemic lesions may indicate tissue viability. In IST-3, patients with this clinical-radiological mismatch allocated to alteplase achieved more favorable outcome than those allocated to control.
A Systematic Review of the Effects of Second-Eye Cataract Surgery on Motor Function
Authors: Sheppard William E. A. , McCarrick Dane , Wilkie Richard M. , Baraas Rigmor C. , Coats Rachel O. 
Published: June 2022

Cataract removal surgery is one of the most commonly performed surgical procedure in developed countries. The financial and staff resource cost that first-eye cataract surgery incurs, leads to restricted access to second-eye cataract surgery (SES) in some areas, including the United Kingdom. These restrictions have been imposed despite a lack of knowledge about the impact of not performing SES on visuo-motor function. To this end, a systematic literature review was carried out, with the aim of synthesising our present understanding of the effects of SES on motor function. Key terms were searched across four databases, PsycINFO, Medline, Web of Science, and CINAHL. Of the screened studies (K = 499) 13 met the eligibility criteria. The homogeneity between participants, study-design and outcome measures across these studies was not sufficient for meta-analyses and a narrative synthesis was carried out. The evidence from objective sources indicates a positive effect of SES on both mobility and fall rates, however, when considering self-report measures, the reduction in falls associated with SES becomes negligible. The evidence for any positive effect of SES on driving is also mixed, whereby SES was associated with improvements in simulated driving performance but was not associated with changes in driving behaviours measured through in vehicle monitoring. Self-report measures of driving performance also returned inconsistent results. Whilst SES appears to be associated with a general trend towards improved motor function, more evidence is needed to reach any firm conclusions and to best advise policy regarding access to SES in an ageing population.Systematic Review Registration:https://osf.io/7hne6/, identifier INPLASY2020100042.
Chemical Composition and Anti-Urolithiatic Activity of Extracts from Argania spinosa (L.) Skeels Press-Cake and Acacia senegal (L.) Willd
Authors: El oumari Fatima Ezzahra , Bousta Dalila , Imtara Hamada , Lahrichi Anissa , Elhabbani Radouane , El mouhri Ghita , Al kamaly Omkulthom , Saleh Asmaa , Parvez Mohammad Khalid , Grafov Andriy , Sqalli Houssaini Tarik 
Published: June 2022

Ethnobotanical studies have reported the traditional medicinal uses of Acacia senegal (L.) Willd. and Argania spinosa (L.) Skeels against kidney stone formation and other chronic kidney diseases. The present work is undertaken to study the litholytic activity and the inhibiting activity of calcium oxalate crystallization by bioactive compounds identified in Argania spinosa (L.) Skeels press-cake (residue of Argan oil) and in Acacia senegal (L.) Willd. The litholytic activity was studied in vitro on cystine and uric acid stones using a porous bag and an Erlenmeyer glass. The study of the inhibiting activity of calcium oxalate crystallization, was based on temporal measurements of the optical density, registered at a 620 nm wavelength for 30 min using an ultraviolet–visible spectrophotometer. The silylation method was performed to identify phytochemicals, followed by gas chromatography coupled with mass spectrophotometry (GC/MS) analysis. The results show significant litholytic activity of Argania Spinosa press-cake hydro-ethanolic extract on uric acid and cystine stones, respectively, with dissolution rates (DR) of 86.38% and 60.42% versus 3.23% and 9.48% for the hydro-ethanolic extract of Acacia senegal exudate. Furthermore, the percentages of nucleation inhibition are 83.78% and 43.77% (p ˂ 0.05) for Argania spinosa and Acacia senegal, respectively. The results point to the detection of 17 phytochemicals in Argania spinosa press-cake extract, the majority of which are phenolic acids and have potent anti-urolithiatic action.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KETERAMPILAN KADER DALAM STIMULASI DAN DETEKSI DINI TUMBUH KEMBANG BALITA
Authors: Islamiyati Islamiyati , Sadiman Sadiman 
Published: June 2022

Monitoring pertumbuhan balita di Posyandu merupakan upaya yang sangat strategis untuk mendeteksi terjadinya gangguan perkembangan. Kader posyandu merupakan kelompok yang paling banyak berinteraksi dengan masyarakat, sehingga memiliki posisi yang sangat baik dan cara yang efektif untuk mendeteksi gangguan pertumbuhan dan perkembangan anak sejak dini. Tujuan penelitian untuk mengetahui faktor-faktor yang berhubungan dengan keterampilan kader dalam melakukan deteksi dini pertumbuhan dan perkembangan anak. Metode penelitian kuantitatif dengan rancangan cross sectional, dilakukan September- Oktober 2020 di wilayah kerja Puskesmas Sritejokencono Lampung Tengah. Sampel 85 orang kader posyandu. Variabel dependen keterampilan kader dalam melakukan deteksi dini pertumbuhan perkembangan balita, variabel independen lama menjadi kader, pengalaman, dukungan tenaga kesehatan, pengetahuan, sikap, motivasi dan sarana prasarana. Instrumen penelitian menggunakan kuisioner dan lembar unujk kerja. Hasil analisis data menggunakan uji regresi logistik ganda, 66% kader kurang terampil dalam melakukan deteksi dini tumbuh kembang anak. Simpulan ada hubungan yang simultan antara pengetahuan kader, sikap, motivasi dan dukungan tenaga kesehatan dengan keterampilan kader dalam melakukan stimulasi dan deteksi dini tumbuh kembang anak. Faktor dominan adalah pengetahuan dimana kader yang memiliki pengetahuan baik akan memiliki keterampilan 13,9 kali lebih baik dibandingkan kader yang memiliki pengetahuan kurang.
Novel technology of high-aspect-ratio etch utilizing coverage-controllable atomic layer deposition
Authors: Kumakura Sho , Sasagawa Hironari , Nishizuka Tetsuya , Kihara Yoshihide , Honda Masanobu 
Published: June 2022

Abstract
We demonstrated a coverage-controllable sidewall protective film by controlling the degree of oxidation during plasma-enhanced SiO2 atomic layer deposition (ALD) as a novel technology to suppress bowing in a high-aspect-ratio-contact (HARC) hole etch process. By depositing SiO2 protective film with atomic order on only the top-local region of patterns, to suppress bowing was achieved during HARC etch without the shrinkage of the bottom critical dimension (CD) and etch-stop. In addition, we investigated the parameters that determine the ALD coverage to estimate the coverage profile of sidewall protective film. By analyzing the relationship between activation time and ALD film thickness at each AR, we confirmed that the coverage is determined by the transport of oxygen radical based on the Knudsen transport model. Furthermore, we developed an ALD simulator from the transport model, and successfully estimated the coverage of protective film during etching to improve the verticality of the HARC profile with small bowing-bottom CD bias.
Studi Kelayakan Pengelolaan Usaha Pembibitan Dan Penggemukan Sapi Po Kebumen
Authors: Nuraeni Nunur , Faisal Ismail Aryadi Muhammad 
Published: June 2022

Kabupaten Kebumen merupakan salah satu sentra peternakan sapi potong lokal, khususnya sapi dari bangsa Peranakan Ongole (PO) san telah memiliki galur tersendiri yaitu Sapi PO Kebumen. Populasi sapi PO di Kabupaten Kebumen mengalami penurunan dari tahun 2010 sampai dengan tahun 2015. Melalui kegiatan Riset Unggulan Daerah pemerintah mencoba melaksanakan study kelayakan pengelolaan usaha peternakan yang berbadan usaha di Kabupaten Kebumen. Tujuan penelitian ini adalah untuk mengetahui faktor/aspek-aspek yang diperlukan dalam pendirian Usaha Peternakan yang Berbadan Hukum, mengetahui layak tidaknya pendirian Usaha Peternakan yang Berbadan Hukum di Kabupaten Kebumen dan menghasilkan Model Operasionalisasi Pengelolaan Usaha Peternakan yang Berbadan Hukum. Berdasarkan hasil mengolah data primer dan sekunder rekomendasi badan usaha pengelolaan pembibitan dan penggemukan Sapi PO Kebumen adalah Perusahaan Daerah dan apabila Perusahaan Daerah cukup lama dalam pendiriannya dapat diawali dengan Usaha Pembibitan dan Penggemukan Sapi PO Kebumen oleh antar Badan Usaha Milik Desa (Bumdes) yang berada di lokasi pembibitan. Pola pengelolaan usaha baik dilaksanakan oleh Perusda maupun Bumdes dibedakan menjadi tiga pola pemeliharaan yaitu a) pemeliharaan oleh perusda, b) pemeliharaan dengan cara gaduhan dimana seluruh asset masih milik peternak dan c) pemeliharaan dengan cara gaduhan dimana seluruh asset bibit betina menjadi milik peternak/plasma. Berdsarkan perhitungan analisis finansial pada masing-masing pola menunjukkan nila NPV pola A dan B positif yaitu Rp. 12.039.167.898,26 dan Rp.3.035.475.194,15, sedangkan pada pola C nilainya negatif yaitu Rp. (4.668.450.161,29). Perhitungan Net B/C pada pola pemeliharaan A adalah 1,2 pada pemeliharaan B 1,16 dan pada pola pemeliharaan C 0,96. Nilai IRR menunjukkan nilai lebih besar dari Diskon Faktor (>20%) pada pola pemeliharaan A, B dan C masing-masing yaitu 55,73, 46,71 dan 46,71. Nilai Payback Period (PP) pada pola pemeliharaan A menunjukkan waktu pengembalian paling cepat yaitu 2,55 tahun atau kurang dari lima tahun, sedangkan pada pola pemeliharaan B dan C menunjukan angka lebih dari lima tahun yaitu 5,26 tahun. Berdasarkan data tersebut, pola pemeliharaan A dan B layak untuk dijalankan dalam mendirikan Perusda Pembibitan dan Penggemukan Sapi PO Kebumen, sedangkan pola C tidak layak. Pola B lebih disarankan untuk dijalankan karena selain untuk pengembangan, pelestarian Sapi PO Kebumen, meningkatkan kegiatan peternakan di Kabupaten Kebumen dan menambah PAD juga dapat mensejahterakan masyarakat peternak.
Kata kunci: Pembibitan, Penggemukan, Sapi PO Kebumen, Perusahaan Daerah
Pengaruh Kombinasi Pemberian Pakan Hijauan dan Konsentrat dengan Bentuk yang Berbeda Terhadap Performa Kelinci Jantan New Zaeland White
Authors: Dughita Putri Awaliya , Fitroh Bagus Andika 
Published: June 2022

Penelitian ini bertujuan untuk mengetahui efek penggunaan kombinasi antara hijauan dan konsentrat dengan bentuk yang berbeda terhadap performa kelinci jantan new zaeland white. Materi yang digunakan pada peneltian adalah kelinci jantan new zaeland white umur 3 bulan sebanyak 32 ekor. Kelinci dikelompokan berdasarkan 4 perlakuan yang berbeda yaitu: Daun Kubis Bunga (DKB) + konsentrat bentuk pellet (T1), Daun Kubis Bunga (DKB) + konsentrat bentuk crumble (T2), Daun Kubis Bunga (DKB) + konsentrat bentuk mash (T3), Daun Kubis Bunga (DKB) + konsentrat bentuk pasta (T4). Metode yang digunakan pada peneltian adalah percobaan dengan completely random design (CRD). Data diolah menggunakan ANOVA (Analysis of variance) bila terdapat perbedaan yang sangat nyata maka dilanjutkan dengan uji Duncan Multipel range test (DMRT). Hasil dari penelitian menunjukan bahwa efek penggunaan kombinasi antara hijauan dan konsentrat dengan bentuk yang berbeda memberikan hasil berbeda nyata (P<0,01) pada konsumsi pakan dan konversi pakan, tetapi memberikan hasil yang nyata (P>0,05) pada pertambahan bobot badan. Kesimpulan dari penelitian ini bahwa efek pemberian kombinasi antara hijauan dengan bentuk konsentrat yang berbeda memberikan perbedaan hasil pada konsumsi pakan dan konversi pakan, pertambahan bobot badan, dan konversi pakan terhadap kelinci jantan new zaeland white, meskipun terdapat perbedaan pada performa tetapi pertumbuhan kelinci terlihat normal dan dalam keadaan sehat.

Kata kunci: kelinci jantan new zaeland white, daun kubis bunga, perbedaan bentuk konsentrat.
THE INFLUENCE OF ANNEALING TEMPERATURE ON THE MAGNETIC PROPERTIES OF CRYO-ROLLED NON-ORIENTED ELECTRICAL STEEL
Authors: Kvackaj Tibor , Demjan Ivo , Bella Peter , Kočiško Róbert , Petroušek Patrik , Fedorikova Alica , Bidulská Jana , Lupták Miloslav , Jandačka Petr , Lascsáková Marcela 
Published: June 2022

The paper is focused on a comparison of the magnetic properties of the non-oriented isotropic electrical steel containing 3.5% Si. The material was processed by conventional ambient temperature rolling and progressive rolling at the cryogenic conditions at liquid nitrogen. Deformations of the samples in both thermal conditions were in the interval εÎ<5;35>[%]. Subsequently, the samples were heat treated at temperatures TÎ<900;1100> [°C]. Measuring of the magnetic properties was carried out in an alternating magnetic field at frequencies f= 50; 100; 150 Hz. At a frequency of 50 Hz were achieved smallest magnetic losses and therefore further measurements were made at a given frequency. Followed measurements of the magnetic induction were conducted at different intensities of the magnetic field. EBSD analyses were performed to obtain the IPF maps on which the resulting structure was evaluated after processing of the material. The specific magnetic losses were compared to different processing methods. The best magnetic properties defined as by minimal values of core loses were reached after samples rolled at cryogenic temperature followed by subsequently annealed. Also, higher proportion of cubic texture was archived after rolling at cryogenic temperature with compared to samples processed at ambient temperature.
Instagram Sebagai Strategi Pengembangan Brand Scarlett Whitening
Authors: Debra Jessica , Owen Miguel , Irwanto Jacob , Herbert Alvin , G Nesya Rhenata 
Published: June 2022

Penggunaan media sosial sebagai media pengembangan dalam melakukan peningkatan pada produk brand di zaman sekarang sangat banyak dan sedang menjadi trend terutama di kalangan anak muda sehingga banyak persaingan antar brand di sosial media. Penelitian ini dilakukan dengan tujuan untuk mengetahui hasil dan efektivitas penggunaan sosial media berupa Instagram sebagai metode strategi pengembangan brand Skincare Scarlett Whitening.
Dalam Penelitian ini Magari menggunakan Metode kualitatif dalam meneliti hasil riset yang dilakukan oleh pihak lain seperti melakukan penelitian melalui hasil survey Instagram mengenai pandangan dan pendapat orang terhadap brand Scarlett Whitening beserta produk-produknya untuk mendapatkan informasi dan data mengenai efektivitas Instagram sebagai strategi pengembangan brand Scarlett Whitening.
Kata Kunci: Marketing, Strategi, Digital, Instagram, Skincare, Sosial Media
Pemanfaatan Konten Media Sosial Instagram Sebagai Media Edukasi Perawatan Hamster yang Benar
Authors: Suhartono Natasya Priscilla , Tjandrawibawa Paulina 
Published: June 2022

Little Milku adalah sebuah media edukasi yang membahas seputar perawatan hamster yang benar karena salah kaprah perawatan hamster masih merajalela di Indonesia. Little Milku baru saja dibentuk pada awal tahun 2022 sehingga awareness terhadap brand masih rendah karena masih belum adanya konten yang diunggah untuk menarik audiens. Penelitian ini bertujuan untuk mengetahui bagaimana perancangan konten yang efektif digunakan sebagai media edukasi perawatan hamster. Media sosial instagram terpilih sebagai media utama untuk menjangkau target audiens Little Milku yang merupakan remaja perempuan Gen Z dengan usia 18-24 tahun karena fitur utamanya yang memanfaatkan konten berupa foto dan video. Penelitian ini menggunakan metode pengumpulan data sekunder melalui studi literatur dari buku dan jurnal yang membahas mengenai promotional media, social media marketing, kartun dan komik. Data juga didapat dari metode pengumpulan primer secara kualitatif melalui hasil wawancara terhadap expert user di bidang ilustrasi dan extreme user yang merupakan followers Little Milku. Selain itu, data juga didapat secara kuantitatif melalui survei kepada 155 followers Instagram Little Milku. Dari penelitian tersebut didapatkan hasil bahwa untuk membuat konten yang bisa secara optimal digunakan sebagai media edukasi maka diperlukan bantuan ilustrasi dengan gaya visual kartun dengan warna yang sesuai dengan selera target audiens untuk memfokuskan atensi target audiens. Konten yang dibuat juga harus memiliki value yang selaras dengan tujuan utama Little Milku yaitu menjadi media edukasi perawatan hamster yang menarik.

Kata Kunci: Konten, Instagram, Edukasi, Perawatan Hamster
Post-radiation complications in children with acute lymphoblastic leukemia who underwent a course of cranial radiation
Authors: Rogova T. S. , Sakun P. G. , Voshedskii V. I. , Vlasov S. G. , Kozel Yu. Yu. , Dmitrieva V. V. , Kozyuk O. V. , Aslanyan K. S. , Vasileva E. V. 
Published: June 2022

Purpose of the study. To analyze the physical and neuropsychiatric development of pediatric patients who underwent cranial irradiation in the period from 2015 to 2020 in the radiotherapy department of the National Research Center of Oncology and to assess the risk of post-radiation complications.Materials and methods. 17 children aged from 3 to 17 years were hospitalized under medical supervision in the department of pediatric oncology of the National Medical Research Centre for Oncology. All the children underwent a course of conformal radiation therapy totally on the brain area and the first two cervical vertebrae in the radiotherapy department of the National Medical Research Centre for Oncology. 13 patients (76.7 %) underwent radiation therapy due to the prevention of neuroleukemia with a total dose of 12 Gy (a dose per fraction was 2 Gy), 2 patients with a confirmed relapse of acute lymphoblastic leukaemia (ALL) (11.65 %), 1 patient with a confirmed diagnosis of neuroleukemia (5.8 %) and 1 patient from the high-risk group (5.8 %) – with a total dose of 18 Gy (a dose per fraction was 2 Gy). Further 75 month regular medical checkup was carried out on the basis of the Regional Children's Clinical Hospital for.Results. None of the surviving patients showed growth retardation. Two patients (11.65 %) complained of increased fatigue, decreased concentration; one patient (5.8 %) showed unmotivated irritability and aggression during the examination. Intellectual development corresponded to age in all patients (100 %). One patient (5.8 %) experienced episodes of nausea and vomiting (grade 1 on the CTCAE scale), three patients (17.7 %) suffered from headache (grade 2 on the CTCAE scale), three patients (17.7 %) complained of fever up to 38 °C (1 degree on the CTCAE scale). Two out of 17 ALL patients died due to disease progression.Conclusion. Taking into account the different time intervals between treatment and the moment of the study (from 9 to 75 months), cranial irradiation demonstrates relative safety for patients undergoing treatment during critical periods of development of both physical and neuropsychic spheres. However, an objective assessment of the development prospects is difficult due to the relatively short time after undergoing therapy (from 9 to 75 months) and a small sample of patients.
Modern treatment of ALK-positive non-small cell lung cancer
Authors: Kharagezov D. A. , Lazutin Yu. N. , Mirzoyan E. A. , Milakin A. G. , Stateshny O. N. , Leyman I. A. , Gappoeva M. A. , Vitkovskaya V. N. , Iozefi K. D. 
Published: June 2022

Lung cancer (LC) takes the first place in the structure of overall oncology in males. More than 1.8 million of new cases of lung cancer (LC) are registered each year worldwide. LC is the leading cause of cancer death in both developing and developed countries, and the 5 years survival rate is as low as 19 %. Many factors explain such unsatisfactory outcomes, including the LC diagnosis at an advanced stage, when the currently available treatments can rarely provide cure. Non-small cell lung cancer (NSCLC) with chromosomal rearrangement of anaplastic lymphoma kinase (ALK) is sensitive to targeted therapy with tyrosine kinase inhibitors (TKIs). Tumor cells containing ALK fusion are sensitive to TKIs – targeted drugs that have significantly improved the results of treatment of patients with ALK-positive NSCLC, half of whom survive more than 6.8 years after diagnosis. The number of patients with ALK-positive NSCLC varies, so ALK rearrangements are detected in about 3–7 % of lung adenocarcinomas, which accounts for up to 60.000 new cases of the disease annually worldwide. ALK-positive NSCLC is observed almost exclusively in adenocarcinomas associated with persons of younger age, male and never smoked or smoked a little. Patients with ALK-positive stage I–III NSCLC are shown treatment similar to patients with wild-type NSCLC, including surgery, radiation therapy, chemotherapy or multimodal treatment, depending on the stage of the tumor process. Numerous ALK TKIs have been developed in recent years, including alectinib, which is the current preferred first-line agent for patients who haven’t received therapy. The study of the mechanisms of resistance has led to the development of next-generation ALK inhibitors that better penetrate the central nervous system, actively affecting brain metastases. This review highlights the current state and prospects for the development of ALK-positive NSCLC therapy.