bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knotless suture and hydrocolloid method improves chest drain wound complication
Authors: Imamura Yoshito , Watanabe Hiroki , Hiramatsu Yoshinori , Okasaka Toshiki 
Published: June 2022

Objective Ligation is a widely used wound closure method after chest drain removal in thoracic surgery. Knotless suture, which does not require ligation or suture removal, has been developed and is currently used in our institution. This study compared the efficacy of the drain wound closure method between knotless suture and our previous mattress suture. Methods We examined the clinical performance of knotless suture for chest drain wound closure in 117 patients who underwent surgery following this method in our department from October 2020 to April 2021. We compared outcomes with those of mattress suture using 2-0 nylon in 115 patients who underwent thoracic surgery at our institution between October 2018 and April 2019. Hydrocolloid dressing is applied to the drain wound after chest drain removal in a knotless suture. We conducted an analysis of both groups based on the condition of wound closure and drain wound complication. Results Appropriate wound closure was obtained and no patient required a prolonged hospital stay because of incomplete wound closure in both methods. The rate of chest drain wound infection for knotless suture (0.0%, 0/117 patient) was significantly lower than that of mattress suture (5.2%, 6/115 patients) at the outpatient follow-up ( p = 0.01). The rate of delayed drain wound healing was also significantly lower than that of mattress suture (0.9% vs. 7.0%; p = 0.02). Conclusions The results of knotless closure were better than those of conventional mattress suture regarding wound complications. Moreover, knotless suturing requires no suture removal, indicating its usefulness.
Daily dyadic coping: Associations with postpartum sexual desire and sexual and relationship satisfaction
Authors: Schwenck Gracielle C , Dawson Samantha J , Allsop David B , Rosen Natalie O 
Published: June 2022

The transition to parenthood involves numerous stressors. Consequently, many new parents report negative changes to their sexual desire, sexual satisfaction, and relationship satisfaction relative to pre-pregnancy, with the most disruption reported at 3-months postpartum. While prior research suggests that dyadic coping—a couple’s capacity to deal with stress effectively and mutually—is positively linked with relationship satisfaction, little is known about how it relates to sexual and relational outcomes in new parents’ daily lives. This study examined how common and negative dyadic coping were associated with new parents’ own and their partner’s daily sexual desire, sexual satisfaction, and relationship satisfaction. New parent couples ( N = 120) completed a baseline survey and 21 days of daily diaries between 3- and 4-months postpartum. Data were analyzed using structural equation modeling. After controlling for mood, for both women who gave birth and their partners, on days that they reported higher common dyadic coping, they reported greater sexual desire, and sexual and relationship satisfaction. On days when women reported lower negative dyadic coping, both they and their partner reported greater relationship satisfaction. When women reported higher common dyadic coping, their partners reported greater sexual desire. When women reported lower negative dyadic coping, they reported greater sexual desire. When partners reported lower negative dyadic coping, they reported greater relationship satisfaction. Focusing on strategies to encourage common and reduce negative daily dyadic coping may be beneficial for sexual and relationship well-being early in the postpartum when couples report experiencing a peak in sexual and relationship challenges.
Feasibility trial of a telehealth support group intervention to reduce anxiety in multiple sclerosis
Authors: Kever Anne , Aguerre Ines M , Vargas Wendy , Straus Farber Rebecca , Levine Libby , Riley Claire S , Vasquez Minnelly , Leavitt Victoria M 
Published: June 2022

Objective Anxiety is common among persons with MS (PwMS), but widely accepted treatments are lacking. Group-based interventions delivered via telehealth are an accessible treatment option requiring clinical trial evidence to support feasibility and initial efficacy. We conducted a pilot feasibility trial of an online support group intervention to reduce anxiety in PwMS. Methods A non-randomized, parallel arm clinical trial was conducted. A total of 31 PwMS were enrolled: 20 completed a 12-week telehealth-delivered support group intervention and 11 were assigned to a survey-only control group. Primary feasibility outcomes were adherence and completion rates. Primary efficacy outcome was anxiety, secondary outcomes were depression, loneliness, distress, self-efficacy, stress, and quality of life. Results Twenty-six participants completed the study. Intervention group adherence (75%) and completion (85%) rates were acceptable. Results indicated a medium size between-group effect, suggesting a greater reduction in anxiety in the intervention group compared to the control group [ U = 39.50, p = 0.045, r = 0.39]. No group differences in other outcomes were observed. Conclusion A telehealth-delivered support group intervention appears feasible for further study and shows initial efficacy for the reduction of anxiety in PwMS.
A Comparison of Pediatric- and Adult-Onset Aquaporin-4 Immunoglobulin G–Positive Neuromyelitis Optica Spectrum Disorder: A Review of Clinical and Radiographic Characteristics
Authors: Tarhan Bedirhan , Rempe Torge , Rahman Sydur , Rodriguez Elsa , Sladky John , Tuna Ibrahim Sacit , Rees John 
Published: June 2022

Background The identification of immunoglobulin G antibodies against the aquaporin-4 channel (AQP-IgG) in the majority of adult patients differentiates neuromyelitis optica as a distinct disease entity. The high specificity of AQP4-IgG for neuromyelitis optica has allowed the identification of seropositive patients with atypical presentations of this disease. Neuromyelitis optica spectrum disorder has been increasingly recognized in children who demonstrate patterns of clinical involvement beyond the traditional boundaries of the optic pathways and spinal cord. Methods This is a single-center, retrospective review comparing demographic, clinical/paraclinical, and laboratory features of children and adults with a serologically confirmed diagnosis of AQP4-IgG-positive neuromyelitis optica spectrum disorder. Results Of 151 reviewed patient charts, 12 pediatric-onset and 31 adult-onset patients had AQP4-IgG-positive  neuromyelitis optica spectrum disorder. The mean age of pediatric-onset neuromyelitis optica spectrum disorder was 12 ± 3.58 years with a female predilection (3:1). Pediatric patients showed more frequent involvement of the brainstem (6/12 [50%]); P = .008) and diencephalon (3/12 [25%]; P = .018). A preceding infection was identifiable in only 3 of 12 (25%) pediatric-onset patients. Moreover, disability as calculated on the expanded disability status scale was less severe in pediatric-onset cases compared to adult-onset cases in their most recent assessment (0 [0-9]) vs 6.5 [0-10]; P = .005). Pediatric-onset patients were also more likely to respond to treatment of acute episodes with corticosteroids ± intravenous immunoglobulin and/or plasmapheresis (Clinical Global Impression–Change scale: 2.5 [1-4] vs 4 [1-6], P = .009). Interpretation This retrospective study was able to compare and contrast pediatric- and adult-onset neuromyelitis optica spectrum disorder. Relative to their adult counterparts, pediatric-onset neuromyelitis optica spectrum disorder patients were more likely to respond to treatment and less likely to be disabled from their disease at follow-up. Therefore, pediatric-onset disease may represent a less virulent form of neuromyelitis optica spectrum disorder.
Motor function and fALFF modulation in convalescent-period ischemic stroke patients after scalp acupuncture therapy: a multi-centre randomized controlled trial
Authors: Zhan Yijun , Pei Jian , Wang Jun , Fu Qinhui , Xu Jia , Yan Minghang , Cai Yiwen , Cui Xiao , Ye Wencheng , Fan Mingxia , Yu Qiurong , Jia Jie 
Published: June 2022

Background:Scalp acupuncture has been found to be effective at improving motor function after ischemic stroke, but few studies examining its central mechanisms of action have been carried out. The aim of this study was to investigate the clinical effects of scalp acupuncture on motor dysfunction and changes in spontaneous brain activity in patients with ischemic stroke.Methods:This was an evaluator- and analyst-blinded, multi-center randomized controlled trial. A total of 108 convalescent-stage ischemic stroke patients with motor dysfunction were allocated to receive either scalp acupuncture combined with rehabilitation treatment (SR group) or rehabilitation treatment alone (RE group). Patients in both groups received treatment 5 times per week for 8 weeks. The primary outcome measure was the Fugl-Meyer assessment (FMA). Secondary outcome measures included the modified Barthel index (mBI), modified Rankin scale (mRS) and values of fractional amplitude of low frequency fluctuation (fALFF) acquired using a resting-state functional magnetic resonance imaging (rs-fMRI) technique.Results:Both groups showed significant improvements in motor function, daily life ability and degree of disability, as measured by FMA, mRS and mBI ( p < 0.05), and the SR group showed a significantly greater improvement ( p < 0.05). Compared with the RE group, the areas where the fALFF values increased in the SR group were located in the cerebellum, praecuneus, precentral gyrus, superior frontal gyrus and parietal lobe. The improvement in FMA scores had the strongest correlation with the baseline fALFF values of the ipsilateral precentral gyrus.Conclusion:Scalp acupuncture improved motor function in convalescent-period ischemic stroke patients, and effects were correlated with regulation of motor-relevant brain regions. The fALFF value of the ipsilateral precentral and postcentral gyri could be potential clinical indices for prognostication of motor dysfunction.Trial registration number:NCT03120650 ( http://www.clinicaltrials.gov ).
Review of Ruxolitinib in the Treatment of Atopic Dermatitis
Authors: Mohney Lindsey A , Singh Rohan , Feldman Steven R. 
Published: June 2022

Objective To review the pharmacokinetics, efficacy, and safety of a newly approved topical Janus kinase 1 (JAK) inhibitor, ruxolitinib (RUX), in patients with atopic dermatitis (AD). Data Sources A literature search was completed May 1, 2022. The term RUX and AD was queried in MEDLINE (PubMed) and EMBASE databases. Study Selection and Data Extraction Peer-reviewed articles written in English and published prior to May 1, 2022 were included. Data Synthesis In the phase II clinical trial, more patients treated with 1.5% topical RUX twice a day had a mean percentage improvement in Eczema Area and Severity Index (EASI) scores from baseline to 4 weeks, when compared to vehicle (71.6% vs 15.5%; P < 0.001). In phase III clinical trials, greater percentage of patients who received 0.75% topical RUX (TRuE-AD1 50.0% and TRuE-AD2 39.0%) or 1.5% topical RUX (TRuE-AD1 53.8% and TRuE-AD2 51.3%) achieved an Investigator’s Global Assessment (IGA) score of 0 (clear) or 1 (almost clear) and had a ≥2-grade improvement from baseline to 8 weeks, when compared to vehicle (TRuE-AD1 15.1% and TRuE-AD2 7.6%; P < 0.001). Relevance to Patient Care and Clinical Practice Atopic dermatitis is a highly prevalent long-term inflammatory skin condition. Pruritus is the main contributor of decreased quality of life in patients with AD. Topical RUX inhibits JAK1 and JAK2 producing antiinflammatory and antipruritic effects. Patients experienced a reduction in pruritus within 2 days. This decreased pruritus translated to increased quality of life and less sleep disturbances. Conclusion Data from phase II and III clinical trials in adult patients suggest RUX is an effective and safe therapy for AD.
Transhepatic double lumen hemodialysis catheter in exhausted vascular access: Feasibility, functionality, and outcome among hemodialysis patients
Authors: Al-Ghamdi Saeed MG , Alharbi Ahmad , Abdorabo Hawazen , Heaphy Emily , Ashour Majed Ahmed 
Published: June 2022

Introduction: Permanent arteriovenous fistula and graft are considered the best options for hemodialysis in end-stage renal disease patients. Temporary access using the internal jugular or femoral veins is the feasible option in acute cases of dialysis and if permanent access is unavailable. Occasionally, however, these access sites are unusable after consecutive blockage of the upper and lower extremities veins. A transhepatic or translumbar approach might be the only unconventional way to ensure a sufficient blood flow for adequate dialysis. Method: Retrospective data on all transhepatic catheters (THCs) in patients at the King Faisal Specialist Hospital and Research Center in Jeddah, Saudi Arabia were collected. The catheters were inserted over a 10-year period (2009–2019). A minimum of 1 year of follow-up from the last catheter insertion was considered for analysis. Results: A total of 12 patients had THCs with a mean age of 42.5 ± 12.2 and pre-insertion mean dialysis duration of 130.0 ± 72.9 months. All catheters were functional from the start with no immediate complications. A total of 35 catheter replacements over guidewires were made with a median of 2.0 catheters (range of 0–10). The mean blood flow was 300 ± 30 ml/minute with a mean Kt/v of 1.4 ± 0.4. The median initial (primary) device service interval was 68 (range 6–1531 days) and the median total access site service interval was 392 (range 76–2698 days). Catheter complications included catheter migration, thrombosis, and bloodstream infection occurring at a rate of 0.12, 0.18, and 0.046 per 100 catheter days respectively. Conclusions: Transhepatic catheters provide safe, feasible access in patients with exhausted vascular access. Patients who undergo THC insertion should be worked up for innovative permanent vascular access or urgent transplantation utilizing unconventional vascular techniques to avoid death due to lack of access.
Field measurement of wind shielding effect of bridge tower for wind-vehicle-bridge system
Authors: Xiang Huoyue , Zhang Botao , Li Zeteng , Li Yongle , Zhang Mingjin , Zhu Jin , Li Longan 
Published: June 2022

Although the wind barrier was set near the bridge tower, more than 10 traffic accidents under crosswinds happen in the bridge tower area within 1 month of the opening operation of a cross-sea bridge. To investigate the wind shielding effect of the bridge tower, a field measurement scheme of wind-vehicle-bridge system, which is a step-by-step test method, was presented and performed on a long span cable-stayed bridge. Firstly, the horizontal profile of wind speed of bridge deck near bridge tower was obtained through the anemometers. Then, the dynamic response of the bridge was measured under the action of normal operating vehicle when the natural wind speed is low. Finally, the response of the moving car was measured when passing through bridge tower, and the wind speed was recorded simultaneously. The results show that the wind-vehicle-bridge system can be tested by step-by-step test method to understand the wind shielding effect of bridge tower. The displacement response of the bridge is still very small when two large trucks meet, and the coupling effect between the vehicle and the bridge is insignificant when a single car passes through the bridge tower. Due to a large porosity of the anti-collision guardrail, the wind speed at the height of 1 m from the bridge deck has changed dramatically when the car leaves the bridge tower on the windward and entering or leaving the bridge tower on the leeward. Among them, the leeward side change is more obvious, and the response of the leeward side vehicle is also greater. The suitable decrease of the anti-collision guardrail porosity in the bridge tower region will improve the running safety of vehicles.
Comparison of Aortobifemoral Bypass and Endovascular Treatment for Chronic Infrarenal Abdominal Aortic Occlusion From the CHAOS (

CH

ronic

A

bdominal Aortic

O

cclusion, A

S

ian Multicenter) Registry
Authors: Fujimura Naoki , Takahara Mitsuyoshi , Obara Hideaki , Ichihashi Shigeo , George Robbie K. , Igari Kimihiro , Banno Hiroshi , Hozawa Koji , Yamaoka Terutoshi , Kian Ch’ng J. , Tan Jimmy W. H. , Park Kihyuk , Skyi Pang Y. C. , Kato Taku , Kawarada Osami 
Published: June 2022

Purpose: To directly compare the clinical outcomes of aortobifemoral bypass surgery (ABF) and endovascular treatment (EVT) for chronic total occlusion (CTO) of the infrarenal abdominal aorta (IAA). Materials and Methods: In this retrospective, multicenter study, we used an international database of 436 patients who underwent revascularization for CTO of the IAA between 2007 and 2017 at 30 Asian cardiovascular centers. After excluding 52 patients who underwent axillobifemoral bypass surgery, 384 patients (139 ABFs and 245 EVTs) were included in the analysis. Propensity score-matched analysis was performed to compare clinical results in the periprocedural period and the long-term. Results: Propensity score matching extracted 88 pairs. Procedure time (ABF; 288 [240–345] minutes vs EVT; 159 [100–205] minutes, p<0.001) and length of hospital stay (17 [12–23] days vs 5 [4–13] days, p<0.001) were significantly shorter in the EVT group than in the ABF group, while the proportions of procedural success (98.9% versus 96.6%, p=0.620), complications (9.1% versus 12.3%, p=0.550), and mortality (2.3% versus 3.8%, p=1.000) were not different between the groups. At 1 months, ABI significantly increased more in the ABF group for both in a limb with the lower (0.56 versus 0.50, p=0.018) and the higher (0.49 versus 0.34, p=0.001) baseline ABI, while the change of the Rutherford category was not significantly different between the groups (p=0.590). At 5 years, compared with the EVT group, the ABF group had significantly better primary patency (89.4±4.3% versus 74.8±4.3%, p=0.035) and survival rates (86.9±4.5% versus 66.2±7.5%, p=0.007). However, there was no significant difference between the groups for secondary patency (100.0%±0.0% versus 93.5%±3.9%, p=0.160) and freedom from target lesion revascularization (TLR) (89.3±4.3% vs 77.3±7.3%, p=0.096). Conclusion: Even with recent advancements in EVT, primary patency was still significantly better for ABF in CTO of the IAA. However, there was no difference between the groups in terms of secondary patency and freedom from TLR at 5 years. Furthermore, there was no difference in procedural success, complications, mortality, and improvement in the Rutherford classification during the periprocedural period, with significantly shorter procedure time and hospital stay in the EVT group.
AMPK-mediated autophagy modulates the inflammatory cytokine expression in intestinal epithelial cells induced by high glucose
Authors: Ma Kun , Li Yun , Dong Xiaolin , Guo Jingjing 
Published: June 2022

Introduction: The homeostasis of intestinal epithelial cells (IECs) is disrupted in diabetes, leading to functional changes of the gastrointestinal tract and increasing the risk of diabetic enteropathy. Methods: The aim of this study is to explore the effect of autophagy on the expression of inflammatory factors under high glucose in vitro. The effect of glucose at different concentrations (5, 10, 30 and 50 Mm) on IEC-6 cells was analyzed. Dorsomorphin (AMPK antagonist) and GSK621 (AMPK agonist) were used to examine the relationship between the autophagy and the AMPK/ULK1 signaling pathway in IEC-6 cells. Results: Our results showed that the high glucose significantly inhibited the growth of IECs, and induced more shrinkage and necrosis of cells. Autophagy was inhibited by high glucose. Furthermore, the levels of cytokines, including IL-22, INF-γ, NOS2, and TNF-α, were significantly increased, which were positively correlated with glucose concentration. Additionally, we confirmed that Dorsomorphin down-regulated the expression of p-AMPK and autophagy protein compared with GSK621. Similar, cellular immunofluorescence also detected low autophagy expression. However, GSK621 and Rapamycin increased the level of autophagy and down-regulated the secretion of pro-inflammatory factors compared with Dorsomorphin. Conclusion: Therefore, our results demonstrate that AMPK mediated autophagy may regulate levels of inflammation in IECs and improve cell survival under high glucose.
Elevated plasma proprotein convertase subtilisin/kexin type-9 is associated with poor prognosis of acute myocardial infarction in hypertension patients
Authors: Wen Xiao-Qin , Huang Kui , Li Jie , Wu Li-Xue , Gao Bo 
Published: June 2022

Whether serum proprotein convertase subtilisin/kexin type 9 (PCSK9) affects the prognosis of patients after the percutaneous coronary intervention (PCI) in hypertension patients remains unknown. A total of 2350 acute myocardial infarction (AMI) subjects with hypertension after PCI were enrolled. Subjects were under 30-months follow-up and divided into the major cardiovascular adverse event (MACE) Group and the non-MACE Group. Cox regression analysis were performed for the risk factors of occurrence of MACE. The relationship between the level of PCSK9 and Gensin score was analyzed by Pearson correlation. Two hundred and thirty-two patients were divided to the MACE Group. Age over 55 (hazard ratio (HR) = 2.52; p = 0.032), smoking (HR = 1.02; p < 0.001), diabetes mellitus (HR = 1.35; p < 0.001) and PCSK9 levels over 1011.3 ng/mL (HR = 1.05; ptdf < 0.001) were risk factors of occurrence of MACE. Baseline levels of PCSK9 was significantly related with Gensini score in ST segment elevation myocardial infarction (STEMI) patients ( r = 0.51), all patients ( r = 0.37) and non-STEMI patients ( r = 0.34, p < 0.001). A high baseline PCSK9 level was the risk factor of poor prognosis of AMI patients with hypertension after PCI. PCSK9 levels were associated with the Gensini score in STEMI patients. Trial registration: This trial was registered at clinicaltrials.gov as NCT04100434.
Motivational Interviewing to Encourage Agricultural Producers’ Use of Hearing Protection Devices: A Mixed-Method Feasibility Study
Authors: Ridge Laura J. , Stefanovsky Nathan J. , Trautner Keane L. , McCullagh Marjorie C. 
Published: June 2022

Background: Workers in production agriculture are frequently exposed to high noise levels and face unique barriers to implementing hearing protection, leading to occupational hearing loss. Motivational interviewing is a promising approach to assist workers in preserving their hearing. Methods: This pilot study used a mixed-method approach to evaluate the feasibility of an innovative motivational interviewing intervention for agricultural producers from February to May 2021. Qualitative data included coaches’ and participants’ comments and were coded using a structural coding approach. Quantitative data included Likert-type-style responses given by participants in a post-intervention survey. Data types were then integrated. Results: Sixteen participants were recruited during the 4-month pilot. Participants’ satisfaction scores averaged above six on a 7-point scale for all satisfaction questions. Implementation factors included the intervention’s flexibility, services provided by the coaches beyond motivational interviewing, and difficulties with recruitment. Conclusions/Applications to Practice: This motivational interviewing intervention was highly acceptable to participants, but factors affecting implementation may challenge scalability.