bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine learning reduced workload for the Cochrane COVID-19 Study Register: development and evaluation of the Cochrane COVID-19 Study Classifier
Authors: Shemilt Ian , Noel-Storr Anna , Thomas James , Featherstone Robin , Mavergames Chris 
Published: January 2022

Abstract
Background
This study developed, calibrated and evaluated a machine learning (ML) classifier designed to reduce study identification workload in maintaining the Cochrane COVID-19 Study Register (CCSR), a continuously updated register of COVID-19 research studies.

Methods
A ML classifier for retrieving COVID-19 research studies (the ‘Cochrane COVID-19 Study Classifier’) was developed using a data set of title-abstract records ‘included’ in, or ‘excluded’ from, the CCSR up to 18th October 2020, manually labelled by information and data curation specialists or the Cochrane Crowd. The classifier was then calibrated using a second data set of similar records ‘included’ in, or ‘excluded’ from, the CCSR between October 19 and December 2, 2020, aiming for 99% recall. Finally, the calibrated classifier was evaluated using a third data set of similar records ‘included’ in, or ‘excluded’ from, the CCSR between the 4th and 19th of January 2021.

Results
The Cochrane COVID-19 Study Classifier was trained using 59,513 records (20,878 of which were ‘included’ in the CCSR). A classification threshold was set using 16,123 calibration records (6005 of which were ‘included’ in the CCSR) and the classifier had a precision of 0.52 in this data set at the target threshold recall >0.99. The final, calibrated COVID-19 classifier correctly retrieved 2285 (98.9%) of 2310 eligible records but missed 25 (1%), with a precision of 0.638 and a net screening workload reduction of 24.1% (1113 records correctly excluded).

Conclusions
The Cochrane COVID-19 Study Classifier reduces manual screening workload for identifying COVID-19 research studies, with a very low and acceptable risk of missing eligible studies. It is now deployed in the live study identification workflow for the Cochrane COVID-19 Study Register.
Phenobarbital for the management of severe acute alcohol withdrawal (the PHENOMANAL trial): a pilot randomized controlled trial
Authors: Filewod Niall , Hwang Stephen , Turner Christian J. , Rizvi Leena , Gray Sara , Klaiman Michelle , Buell Danielle , Ailon Johnathan , Caudarella Alexander , Ginocchio Galo F. , Santos Marlene , Sandhu Gyan , Dewhurst Norman , Sequeira Kelly , Burns Karen E. A. 
Published: January 2022

Abstract
Background
Benzodiazepines are considered first-line treatment for patients experiencing severe acute alcohol withdrawal syndrome (sAAWS). Although several medications have been evaluated as potential adjuvant treatments for sAAWS, barbiturates show particular promise.

Objective
In the PHENOMANAL trial, we will assess the feasibility of conducting an allocation-concealed, quadruple-blinded, randomized controlled trial (RCT) comparing symptom-triggered benzodiazepine therapy with either a single dose of adjuvant intravenous (IV) phenobarbital (7.5 mg/kg of ideal body weight) or a single dose of matching IV placebo for patients with sAAWS.

Methods
We will recruit adult patients from the Emergency Department, Intensive Care Unit, or hospital wards with a Clinical Institute of Withdrawal – Adult revised (CIWA-Ar) score of 16 or more after receipt of at least 60 mg of diazepam or equivalent within 16 h of diagnosis of sAAWS, and an anticipated need for hospitalization. We will randomize participants (n=39) in a 2:1 manner to treatment and placebo groups, respectively. The primary objective of the PHENOMANAL pilot trial will be to demonstrate our ability to recruit the desired population over the trial period. As secondary objectives, we will evaluate clinician compliance with the treatment protocols, assess crossover rates from the placebo arm to the treatment arm, and obtain preliminary estimates of treatment effect. All trial participants will be followed for 7 days or until hospital discharge.

Relevance
The PHENOMANAL trial is novel in investigating a new treatment for a common and understudied condition, repurposing an existing medication for a novel indication, and addressing an important evidence gap. Through conduct of the multidisciplinary pilot trial, we aim to advance methodology in acute care research through the use of a hybrid consent model and inform the design of a large-scale trial.

Trial registration
ClinicalTrials.gov Registration NCT03586089; first registered July 13, 2018.
Feasibility and preliminary efficacy of a school-based health and well-being program for adolescent girls
Authors: White Karen , Lubans David R. , Eather Narelle 
Published: January 2022

Abstract
Background
The primary aim of this pilot study was to evaluate the feasibility and preliminary efficacy of a school-based health and well-being program (Health and Well-being for Girls: HWBG) on adolescent girls’ well-being, mindfulness, screen-time, and physical activity.

Method
The HWBG program was evaluated using a group randomized controlled trial (RCT) in one secondary school. A convenience sample of female students in Grade 8 (mean age 14 ± 0.5 years) was recruited for the study (n=4 classes; 89 girls). The 20-week multi-component HWBG program, guided by Self-Determination Theory and Acceptance and Commitment Therapy, was designed and delivered by a member of the research team. Randomization occurred prior to baseline assessments at the class level (n=4 classes) into dose-matched treatment conditions (i.e., two classes received the HWBG intervention and two classes received an alternate elective course as a wait-list control group). Process evaluation measures of recruitment, retention, adherence, and satisfaction were used to determine program feasibility. This study was designed to assess feasibility (primary outcome) and preliminary efficacy (secondary outcomes), rather than effectiveness. Preliminary efficacy of HWBG for improving mental and social health, screen-time, and physical activity were measured and analyzed using linear mixed-models.

Results
“The health and well-being program” targeting adolescent girls was found to be feasible for implementation as an elective course in a secondary school setting. Participants in the HWBG program reported high levels of satisfaction, the majority of lessons (45 out of 50), were implemented as planned and adherence to the planned HWBG program content was very high. Medium positive effects on mental health (d=0.45) and social health (d=0.50) were observed. Small effects were observed for physical activity, and no significant intervention effects were found for levels of recreational screen time. Participant ratings showed high levels of perceived benefit and enjoyment as indicated in the evaluation data (mean rating of 4.44 out of a possible 5.0) when asked whether the program was enjoyable.

Conclusion
The study provides preliminary support for HWBG as a potentially feasible and enjoyable program suitable for use with adolescent girls in the secondary school setting. Potential of the study for facilitating improvements in pro-social and psychological well-being is also supported.

Trial registration
ACTRN12617000157370. The trial was registered with the Australian New Zealand Clinical Trials Registry.
Feasibility of an MI-CBT ketogenic adherence program for older adults with mild cognitive impairment
Authors: Sheffler Julia L. , Arjmandi Bahram , Quinn Jamie , Hajcak Greg , Vied Cynthia , Akhavan Neda , Naar Sylvie 
Published: January 2022

Abstract
Background
The National Institutes of Health Obesity-Related Behavioral Intervention Trials model for intervention development was used to establish the feasibility and proof of concept of a motivational ketogenic nutrition adherence program for older adults with mild cognitive impairment.

Methods
This was a single-arm, single-center feasibility trial. A comprehensive assessment protocol, including a clinical interview, neuropsychological testing, and genetic sequencing was used as an initial screening. Nine participants (aged 64–75) with possible amnestic mild cognitive impairment were consented for the intervention. Participants completed pre- and post-intervention neuropsychological assessments using the updated Repeatable Battery for Assessment of Neuropsychological Status. Participants tracked their macronutrient consumption using food diaries and ketone levels using urinalysis test strips daily. Mood and other psychosocial variables were collected through surveys, and qualitative exit interviews were completed.

Results
100% of participants who began the trial completed the 6-week ketogenic nutrition adherence program, including completion of the pre- and post-assessments. Eight participants achieved measurable levels of ketones during the program. The average self-rated adherence across the program was 8.7 out of 10. A Wilcoxon Signed-Rank test demonstrated significant improvement in cognitive performance from baseline (median = 88) to follow up (median = 96, Z = − 2.26, p = .024). The average difference in cognitive performance from baseline to follow-up was − 7.33 (95% CI − 12.85, − 1.82).

Conclusions
Results supported the feasibility for moving to the next phase and demonstrated proof of concept for the intervention. The next step is a randomized pilot trial to test clinical signals of effect compared to a control condition.

Trial registration
This trial was retrospectively registered with clinicaltrials.gov on July 13, 2021. The trial number is NCT04968041.
Plasma orexin A does not reflect severity of illness in the intensive care units patients with systemic inflammation
Authors: Akaishi Masahiro , Hashiba Eiji , Takekawa Daiki , Kushikata Tetsuya , Hirota Kazuyoshi 
Published: January 2022

Abstract
Background
Systemic inflammatory response occurs by sepsis and invasive surgery. Recent articles suggest that not only CRP but also procalcitonin, presepsin, and neutrophil gelatinase-associated lipocalin may reflect the severity of systemic inflammation. In addition, as systemic inflammation could degenerate orexin neurons, plasma orexin A might also be a good biomarker to predict the severity. Thus, we have determined relation between plasma biomarker and severity of illness score in patients with systemic inflammation.

Methods
Previous database (UMIN000018427) was used to secondly determine which plasma biomarkers may predict the severity of illness in the ICU patients with systemic inflammation (n = 57, 31 non-sepsis surgical patients and 26 sepsis patients). We measured plasma levels of orexin A, CRP, procalcitonin, presepsin, and neutrophil gelatinase-associated lipocalin were measured, and APACHE II score was assessed in these patients at their admission to the ICU. Data are shown as mean ± SD. Statistical analyses were done with unpaired t test. The correlation between APACHE II score and plasma biomarkers were examined using Pearson’s correlation coefficient and a least squares linear regression line.

Results
Demographic data did not differ between sepsis and non-sepsis groups. However, APACHE-II score was significantly higher in sepsis group than those in non-sepsis group (20.9 ± 6.6 vs 15.8 ± 3.2, p < 0.01). There were significant correlations between APACHE II score and plasma CRP (r = 0.532, p < 0.01), procalcitonin (r = 0.551, p < 0.01), presepsin (r = 0.510, p < 0.01), and neutrophil gelatinase-associated lipocalin (r = 0.466, P < 0.01) except orexin A.

Conclusion
All plasma biomarkers tested except orexin A may reflect the severity of illness in patients with systemic inflammation.
Respuesta del primer nivel de atención de salud del Perú a la pandemia COVID-19
Authors: Villanueva-Carrasco Rosa , Domínguez Samamés Rafael , Salazar De La Cruz Miriam , Cuba-Fuentes María Sofía 
Published: January 2022

Desde el primer caso reportado por el nuevo coronavirus en el Perú se han implementado distintas estrategias para mejorar los servicios de salud, con gran énfasis en la respuesta hospitalaria. En el presente artículo, hacemos un recuento de las acciones orientadas al primer nivel de atención de salud que el gobierno peruano intenta implementar. Proponemos medidas clave a cumplir como implementación de clínicas de sintomáticos en el primer nivel de atención de salud, cuidados sanitarios en domicilio, inserción de médicos de familia y uso intensivo de consultas telefónicas y otra TICs que al adoptarse e implementarse a la realidad peruana, lograrían una respuesta más efectiva ante la pandemia por COVID-19.
Report on a doctoral dispute at the Imperial Kazan University April 6, 1908
Authors: Zhilin Ivan N. 
Published: January 2022

The doctor N. A. Sinakevich defended his thesis for the degree of Doctor of Medicine under the title On the question of the vasomotor nerves of the thyroid gland.
In the introductory speech, the dissertator outlined a brief history of the issue. (See Neurological Bulletin, Vol. XIV, nos. 3-4).
(Mis)Information on Digital Platforms: Quantitative and Qualitative Analysis of Content From Twitter and Sina Weibo in the COVID-19 Pandemic
Authors: Kreps Sarah , George Julie , Watson Noah , Cai Gloria , Ding Keyi 
Published: January 2022

Background
Misinformation about COVID-19 on social media has presented challenges to public health authorities during the pandemic. This paper leverages qualitative and quantitative content analysis on cross-platform, cross-national discourse and misinformation in the context of COVID-19. Specifically, we investigated COVID-19-related content on Twitter and Sina Weibo—the largest microblogging sites in the United States and China, respectively.

Objective
Using data from 2 prominent microblogging platform, Twitter, based in the United States, and Sina Weibo, based in China, we compared the content and relative prevalence of misinformation to better understand public discourse of public health issues across social media and cultural contexts.

Methods
A total of 3,579,575 posts were scraped from both Sina Weibo and Twitter, focusing on content from January 30, 2020, within 24 hours of when WHO declared COVID-19 a “public health emergency of international concern,” and a week later, on February 6, 2020. We examined how the use and engagement measured by keyword frequencies and hashtags differ across the 2 platforms. A 1% random sample of tweets that contained both the English keywords “coronavirus” and “covid-19” and the equivalent Chinese characters was extracted and analyzed based on changes in the frequencies of keywords and hashtags and the Viterbi algorithm. We manually coded a random selection of 5%-7% of the content to identify misinformation on each platform and compared posts using the WHO fact-check page to adjudicate accuracy of content.

Results
Both platforms posted about the outbreak and transmission, but posts on Sina Weibo were less likely to reference topics such as WHO, Hong Kong, and death and more likely to cite themes of resisting, fighting, and cheering against coronavirus. Misinformation constituted 1.1% of Twitter content and 0.3% of Sina Weibo content—almost 4 times as much on Twitter compared to Sina Weibo.

Conclusions
Quantitative and qualitative analysis of content on both platforms points to lower degrees of misinformation, more content designed to bolster morale, and less reference to topics such as WHO, death, and Hong Kong on Sina Weibo than on Twitter.
Об истории возрождения буддизма в Бурятии и Монголии в 1960–1970 гг. по архивным документам из личного архива П. Б. Балданжапова
Authors:   Institute for Mongolian, Buddhist and Tibetan Studies, Siberian Branch of the RAS (8A, Sakhyanova St., 670047 Ulan-Ude, Russian Federation), Vanchikova Tsymzhit P. 
Published: January 2022

The purpose of the article is to provide new information about the initial stage of the process of restoration and revival of Buddhist traditions after the period of repression and atheistic prohibitions. It shows the role of representatives of the Buddhist clergy in the person of the Khambo lamas of the USSR and the MPR Zh.-D. Gomboev, S. Gombozhav and P. B. Baldanzhapov in establishing international relations between the countries, in the creation and opening of the Buddhist Institute in Ulaanbaatar at the Gandantekchenlin Monastery in 1970. The article is written mainly onthe source base of archival materials stored in the private personal archive of P. B. Baldanzhapov kept in the funds of the Center of Oriental Manuscripts and Xylographs of the IMBT SB RAS, such as personal correspondence, copies and drafts of letters of appeals to government and other administrative organizations, plans and programs of visits and receptions of foreign delegations, reports and messages, drafts of articles, photographs. While writing the article, such research methods were used as historical retrospective, which showed the reason for the decline of Buddhist traditions by the early 60s of the last century, a comparative method that allowed assessing the contribution of Buddhist figures in historical perspective, as well as content analysis used for working with archival documents. Results. It has been stated that since the late 50-ies the policy of the Soviet government towards all confessions, including Buddhist, has changed. The main reason for which were political interests of the state aimed at improving its political image in the world, in expanding international relations of the USSR with the states of Southeast Asia, which allowed the Central Religious Board of the Buddhists of the USSR to establish ties with foreign Buddhist organizations and prominent religious public figures of other countries. Since the mid-60-70-ies, due to the joint efforts of Buryat and Mongolian Buddhist figures, actions were initiated for obtaining permission to open a Buddhist educational institution in Ulan-Bator, with the opening of which in 1970 the main threat to the existence of the Buddhist church among the Mongolian peoples was solved t.e. the disappearance of the system of education and training of young lamas.
Effect of Concentration of Entomopathogenic Nematodes (Steinernema spp.) to Bemisia tabaci Genn. (Hemiptera; Aleyrodidae) On Red Chili Plants
Authors: Sunarto Toto - , Pubarianto Fahira Endaningsih 
Published: January 2022

Bemisia tabaci is an important pest on red chili plants. The entomopathogenic nematodes Steinernema spp. has the potential to control insect pest populations. The purpose of this study was to obtain the concentration of Steinernema spp. the most effective in controlling B. tabaci on red chili plants. The experiment was conducted at the Greenhouse, Faculty of Agriculture, Universitas Padjadjaran, Jatinangor, from January to September 2020. The study used experimental methods in-vitro and in-vivo. The in-vitro experiment used a completely randomized design to observe the mortality of B. tabaci. The in-vivo experiment used a Randomized Block Design to observe the population of B. tabaci. The experiment consisted of seven treatments and four replications. The treatments consisted of: control (without Steinernema spp.), 50, 100, 150, 200, 250, and 300 IJ/ml (IJ = third infective juvenile). Each treatment was infested with 20 second nymphs B. tabaci and using red chili plants 30 days after planting. The results showed that the entomopathogenic nematode Steinernema spp. at a concentration of 300 IJ/ml, the most effective in causing mortality of B. Tabaci and at concentration of 100 IJ/ml can suppress B. tabaci population on chilli plant at lower level in 12 days after application.
Modifikasi Suhu Uji Pemunculan Radikula untuk Mempersingkat Pengujian Vigor Benih Jagung
Authors: Ul Khusna Aghniya , Zamzami Ahmad , Ilyas Satriyas 
Published: January 2022

Radicle emergence (RE) atau pemunculan radikula adalah uji vigor cepat yang direkomendasikan ISTA tahun 2014 untuk benih jagung pada suhu 20 °C selama 66 jam. Tujuan penelitian ini adalah mengembangkan uji RE benih jagung pada suhu 25 °C dan menentukan satu waktu pengamatan yang tepat untuk mempersingkat periode pengujian vigor benih jagung. Penelitian dilakukan di Laboratorium Penyimpanan dan Pengujian Mutu Benih, dan Kebun Percobaan Cikabayan IPB mulai Desember 2019 sampai dengan Maret 2020. Rancangan percobaan yang digunakan dalam pengujian RE yaitu split-plot, dengan sembilan lot benih (varietas) sebagai petak utama dan 14 waktu pengamatan (jam ke- 27, 30, 33, 36, 39, 42, 45, 48, 51, 54, 57, 60, 63, dan 66 setelah pengecambahan) sebagai anak petak. Rancangan kelompok lengkap teracak satu faktor (lot benih) digunakan untuk pengujian mutu benih di laboratorium dan vigor bibit di lapangan. Hasil uji RE kemudian dikorelasikan dengan daya berkecambah, vigor benih, dan vigor bibit. Hasil penelitian menunjukkan bahwa uji RE pada benih jagung dengan metode uji antar kertas pada suhu 25 °C dan diamati saat 51 jam ± 15 menit setelah pengecambahan terbukti berkorelasi erat dan dapat memprediksi daya berkecambah, rataan waktu perkecambahan, indeks vigor, kecepatan tumbuh, dan rataan waktu pemunculan bibit.
Kata kunci: daya berkecambah, korelasi, lot benih, varietas, vigor benih, vigor bibit
REKONSTRUKSI INTERIOR BANGUNAN SEJARAH OPTIK SURYA DENGAN MODEL 3D
Authors: Azis Baskoro , Safrilia Adisti , Wijaya Ida Bagus Ananta 
Published: January 2022

Bangunan bersejarah di Kota Malang merupakan salah satu peninggalan bersejarah yang menjadi bukti penjajahan. Optik Surya merupakan salah satu bangunan bersejarah yang dibiarkan karena perawatan bangunan yang mahal sehingga menyebabkan bangunan tersebut terlihat lusuh di Kota Malang. Pelestarian dan rekosntruksi pada bangunan bersejarah terutama pada interior masih belum seimbang dengan eksteriornya. Maka perlu diadakan pelestarian dengan metode rekonstruksi 3D interior pada bangunan Optik Surya dengan menganalisa elemen desain dan prinsip desain untuk mengetahui ciri khas bangunan. Metode yang digunakan adalah kualitatif deskriptif, dengan mengumpulkan data observasi lapangan, tinjauan pustaka dan data visual. Hasil temuan berupa elemen bentuk , elemen pencahyaan dan warna yang paling mendominasi pada perbandingan antara elemen dan prinsip desain interior bangunan bersejarah Optik Surya dengan suasana pada tahun 1973 dan masa sekarang.
ANALYSIS OF NIGERIAN NATURAL GAS CONSUMPTION (1990 – 2020). A VECTOR ERROR CORRECTION MODEL APPROACH
Authors: Nwabueze Gift , Joel Ogbonna , Nwaozuzu Chijioke 
Published: January 2022

This paper investigates the relationship between natural gas consumption, natural gas price, crude oil price, Foreign direct Investment and per capita GDP in Nigeria to ascertain their causal effects and dependencies by using time series data from 1990 to 2020 in an econometric platform using Vector Error Correction model (VECM). The result of VECM estimate, Granger causality test and Variance decomposition test all suggest the presence of a strong positive correlation between natural gas consumption and economic growth (represented by per capita GDP) in Nigeria, even though the price of natural gas is not consumption determined. This implies that economic policies that encourage production of goods and services in Nigeria will tend to boost natural gas consumption in Nigeria. Finally, foreign direct investment showed negligible impact on natural gas consumption but was more impacted by crude oil price. This suggests that the rate of influx of foreign investment into Nigeria is more influenced by international crude oil price not necessarily by the Nigerian natural gas consumption, all things being equal.