bluuebunny/crossref_metadata_2025_split huggingface dataset:
OGC P43 Oncological outcomes following the introduction of laparoscopic gastric mobilisation during Ivor Lewis Oesophagogastrectomy within a regional Scottish centre
Authors: Smith Lucy , Khan Khurram , MacKay Colin , Craig Carol , Forshaw Matthew , Macdonald Andrew , Gall Lewis 
Published: December 2022

Abstract

Background
Ivor Lewis Oesophagogastrectomy (ILO) is a potentially curative but highly morbid surgery. Minimally invasive techniques by comparison have demonstrated improved post-operative outcomes for patients. Hybrid laparoscopic gastric mobilisation (LGM) combined with an open right thoracotomy was introduced in our centre in 2019. This study assessed oncological outcomes between ILO with LGM and a fully open ILO, following this local change in operative technique.

Methods
This was a retrospective study of patients undergoing ILO at a single tertiary unit over a 5-year period (2017–2021). All patients undergoing open ILO were compared with those who had ILO with LGM. Resected lymph node count was used as a marker for oncological outcomes and median length of hospital stay a marker for post-operative outcomes.

Results
During the study period, 42 patients had open ILO and 32 had ILO with LGM. Patient demographics were similar between groups, with the majority receiving neoadjuvant chemotherapy (Open ILO 92.9% vs LGM 96.9%, p=0.629). Following local introduction of LGM in 2019, it immediately became the predominant method of gastric mobilisation during ILO (58% cases in 2019; 100% cases in 2020; 73% cases in 2021). Median total lymph node count resected was similar between LGM 17(15–25) vs open ILO 18 (16–24), p=0.643. Overall, length of stay was shorter in those having LGM compared to open (16 (11–21) vs 18 (11–36)), although this did not reach statistical significance (p=0.129).

Conclusions
Introduction of a hybrid minimally invasive technique for oesophagogastrectomy within our regional centre, has been associated with similar oncological outcomes to the traditional open approach. Further evaluation is required to ascertain the potential patient benefits of a LGM on post-operative outcomes within our patient cohort.
OGC P47 The Role of Endoscopic Ultrasound Scan In Staging Patients With Oesophageal Cancer- A Retrospective Single Centre Study
Authors: Ammar Ahmed , Anis Fady , Fabelurin Christiana , Herbert Saul , Awad Sherif , Leeder Paul , Iftikhar Syed , El-Sharkawy Ahmed 
Published: December 2022

Abstract

Background
There are conflicting opinions on the role of Endoscopic Ultrasound (EUS) in the staging of oesophageal cancer (OG) patients which can complicate and delay intervention. We aim to audit the use of EUS in the OG cancer staging pathway as well as assess accuracy in selected cases.

Methods
A retrospective audit of the hospital database of patients diagnosed with oesophageal carcinoma between January 2016 and March 2021.The duration between the first MDT and EUS performed was calculated. Concordance between initial CT and EUS stage as well as histology in patients that were offered direct to surgery were evaluated using Cohen's Weighted Kappa.

Results
A total of 301 patients were identified. Overall, there was a moderate agreement (K=0.526) between CT and EUS reported T Staging(p&lt;0.001). There was substantial agreement (K=0.798) between CT reporting T2, T3 and EUS(p&lt;0.0005). Twenty-seven patients underwent upfront surgery-11 were T1, 16 were T2 and T3 disease. Comparing to final histology, EUS reported an accurate T1 stage in 36.3% compared with 0% with CT (p=0.018), whereas T2 and T3 disease were accurately reported with EUS and CT in 43.7% and 37.5% respectively (p=0.375). The median number of days between first MDT and EUS was 14 days (8,18) and this was requested after CT and PET CT results were available in 80% of cases.

Conclusions
This audit demonstrates minor differences between EUS and CT for T2 and T3 disease and therefore unlikely to alter management. However, EUS is superior to CT for staging Tx and T1 disease and is therefore likely to impact on the treatment options. EUS also contributed to prolonged pre-treatment staging time. Adopting a selective approach to EUS could result in overall reduction of waiting times from referral to decision making and increase cost-effectiveness.
Negative Social Interactions at the Intersection of Gender, Race and Immigration Status in Canada
Authors: Chuang Deng-Min , Leung Vivian W Y , Lung Yu , Fang Lin 
Published: December 2022

Abstract
Negative social interactions (NSIs), defined as upsetting interpersonal encounters in daily life, are associated with adverse mental health conditions. Guided by an intersectional perspective, this study explored the impacts of gender, race and immigration status on the experiences of NSIs, using nationally representative data from the 2012 Canadian Community Health Survey-Mental Health (CCHS-MH). The sample consisted of 21,932 participants across Canada. Gender-specific multivariable logistic regression models were used to estimate the effects of race, immigrant status and the interaction term on the likelihood to experience NSIs. Study results showed that women (32.3 per cent) reported significantly more NSIs than men (25.4 per cent). For men, being an immigrant was significantly associated with a lower likelihood of experiencing NSIs; race did not have a significant effect on NSIs. Furthermore, the results revealed that racialised Canadian-born women were more likely to report NSIs than racialised immigrant women, whilst immigration status had no effect among white women. This study suggests the distinct influences of intersecting identities of race, gender and immigration status and that social workers should incorporate an intersectional lens when exploring clients’ social relationships and environments.
Establishing ground truth in the traumatic brain injury literature: if replication is the answer, then what are the questions?
Authors: Priestley Diana R , Staph Jason , Koneru Sai D , Rajtmajer Sarah M , Cwiek Andrew , Vervoordt Samantha , Hillary Frank G 
Published: December 2022

AbstractThe replication crisis poses important challenges to modern science. Central to this challenge is re-establishing ground truths or the most fundamental theories that serve as the bedrock to a scientific community. However, the goal to identify hypotheses with the greatest support is non-trivial given the unprecedented rate of scientific publishing. In this era of high-volume science, the goal of this study is to sample from one research community within clinical neuroscience (traumatic brain injury) and track major trends that have shaped this literature over the past 50 years. To do so, we first conduct a decade-wise (1980–2019) network analysis to examine the scientific communities that shape this literature. To establish the robustness of our findings, we utilized searches from separate search engines (Web of Science; Semantic Scholar). As a second goal, we sought to determine the most highly cited hypotheses influencing the literature in each decade. In a third goal, we then searched for any papers referring to ‘replication’ or efforts to reproduce findings within our &gt;50 000 paper dataset. From this search, 550 papers were analysed to determine the frequency and nature of formal replication studies over time. Finally, to maximize transparency, we provide a detailed procedure for the creation and analysis of our dataset, including a discussion of each of our major decision points, to facilitate similar efforts in other areas of neuroscience. We found that the unparalleled rate of scientific publishing within the brain injury literature combined with the scarcity of clear hypotheses in individual publications is a challenge to both evaluating accepted findings and determining paths forward to accelerate science. Additionally, while the conversation about reproducibility has increased over the past decade, the rate of published replication studies continues to be a negligible proportion of the research. Meta-science and computational methods offer the critical opportunity to assess the state of the science and illuminate pathways forward, but ultimately there is structural change needed in the brain injury literature and perhaps others.
Ethics for educational research in regions of protracted armed conflict and crisis: a participatory community project in the Lake Chad region
Authors: Ebubedike Margaret , Akanji Tajudeen , Kunock Afu Isaiah , Fox Alison 
Published: December 2022

Abstract
This paper critically considers the ethics of conducting community-based participatory research, which engages community members, including young people, as active participants in research about them, in the context of the protracted armed conflict and crisis of the Lake Chad region. We highlight the intersection of cultural practices and religious belief systems prevalent in this context, which further deepens the complexities arising from researching populations experiencing protracted armed conflict and crisis. This raises the possibilities of understanding research ethics in such contexts via the lens of a postcolonial frame. Using participatory photography allowed engagement in face-to-face collaborative data collection. In doing so, the research team was able to pay attention to verbal and non-verbal dimensions arising from community engagement, which supported learning about the community’s positions and needs as a resource for thinking about how these might need accommodation in the project. It is not straightforward to lead this kind of project as researchers based in the Global North in terms of deciding what is right and what research practices would be considered just, compassionate, and trustworthy in these contexts. The approach taken was to distribute leadership in the project to include local actors such as NGOs working at local levels, community leaders (traditional and religious), as well as to draw on in-country research teams and the members of each of the participating communities. We argue that a more nuanced understanding about how to mitigate identified ethical concerns has implications for enhancing community-based research, especially when researching similar populations.
Cortex2vector: anatomical embedding of cortical folding patterns
Authors: Zhang Lu , Zhao Lin , Liu David , Wu Zihao , Wang Xianqiao , Liu Tianming , Zhu Dajiang 
Published: December 2022

Abstract
Current brain mapping methods highly depend on the regularity, or commonality, of anatomical structure, by forcing the same atlas to be matched to different brains. As a result, individualized structural information can be overlooked. Recently, we conceptualized a new type of cortical folding pattern called the 3-hinge gyrus (3HG), which is defined as the conjunction of gyri coming from three directions. Many studies have confirmed that 3HGs are not only widely existing on different brains, but also possess both common and individual patterns. In this work, we put further effort, based on the identified 3HGs, to establish the correspondences of individual 3HGs. We developed a learning-based embedding framework to encode individual cortical folding patterns into a group of anatomically meaningful embedding vectors (cortex2vector). Each 3HG can be represented as a combination of these embedding vectors via a set of individual specific combining coefficients. In this way, the regularity of folding pattern is encoded into the embedding vectors, while the individual variations are preserved by the multi-hop combination coefficients. Results show that the learned embeddings can simultaneously encode the commonality and individuality of cortical folding patterns, as well as robustly infer the complicated many-to-many anatomical correspondences among different brains.
Simultaneous Determination of Phenylethanoid Glycosides and Antioxidant Activity of Syringa pubescens Turcz. from Different Geographical Origin in China
Authors: Yang Qinyu , Wang Xinsheng , Zhang Yanlong , Li Mengyuan , Wang Panxu , Zhang Jiameng , Liu Kun , Wu Yanfang , Shen Guomin , Ma Zhanqiang 
Published: December 2022

Abstract
A high-performance liquid chromatograph with diode array detector was established for the simultaneous determination of five phenylethanoid glycosides in Syringa pubescens Turcz. The optimal chromatographic conditions were achieved on a Zorbax C18 column using gradient elution with 0.5% aqueous acetic acid and acetonitrile as the mobile phase at the flow rate of 1.0 mL/min. The detection wavelength was developed as follows: 0–10 min, 276 nm; 10–45 min, 332 nm. The validation of the method including linearity, precision, stability, accuracy, repeatability and recovery was tested. The chemometric analysis including hierarchical cluster analysis and principal component analysis was employed to investigate the similarity and difference of samples from different geographical origin. The results revealed that S. pubescens samples were divided into four clusters based on the phenylethanoid glycosides contents. Antioxidant activity of extract was measured using three different methods including α,α-diphenyl-β-picrylhydrazyl and 2,2-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical scavenging assays, and ferric reducing antioxidant power assay. Furthermore, different phenylethanoid glycosides exhibited different contribution to antioxidant capacities. This study provides a foundation for the quality evaluation and offers scientific data for the utilization of S. pubescens resources.
Combining neutrophil and macrophage biomarkers to detect active disease in ANCA vasculitis: a combinatory model of calprotectin and urine CD163
Authors: Anton-Pampols Paula , Martínez Valenzuela Laura , Fernández Lorente Loreto , Quero Ramos Maria , Gómez Preciado Francisco , Martín Capón Irene , Morandeira Francisco , Manrique Escola Joaquín , Fulladosa Xavier , Cruzado Josep Maria , Torras Joan , Draibe Juliana 
Published: December 2022

ABSTRACTBackgroundCD163 and calprotectin have been proposed as biomarkers of active renal vasculitis. This study aimed to determine whether the combination of serum/urine calprotectin (s/uCalprotectin) and urinary soluble CD163 (suCD163) increases their individual performance as activity biomarkers.MethodsWe included 138 patients diagnosed with ANCA vasculitis (n = 52 diagnostic phase, n = 86 remission). The study population was divided into the inception (n = 101) and the validation cohorts (n = 37). We determined the s/uCalprotectin and suCD163 concentration using enzyme-linked immunoassay at the diagnostic or at the remission phase. Receiver operating characteristic (ROC) curves were conducted to assess the biomarkers’ classificatory values. We elaborated a combinatorial biomarker model in the inception cohort. The ideal cutoffs were used in the validation cohort to confirm the model's accuracy in the distinction between active disease and remission. We added the classical ANCA vasculitis activity biomarkers to the model to increase the classificatory performance.ResultsThe concentrations of sCalprotectin and suCD163 were higher in the diagnostic compared with the remission phase (P = .013 and P &lt; .0001). According to the ROC curves, sCalprotectin and suCD163 were accurate biomarkers to discern activity [area under the curve 0.73 (0.59–0.86), P = .015 and 0.88 (0.79–0.97), P &lt; .0001]. The combinatory model with the best performance in terms of sensitivity, specificity and likelihood ratio included sCalprotectin, suCD163 and haematuria. Regarding the inception and the validation cohort, we obtained a sensitivity, specificity and likelihood ratio of 97%, 90% and 9.7, and 78%, 94% and 13, respectively.ConclusionsIn patients with ANCA vasculitis, a predictive model combining sCalprotectin, suCD163 and haematuria could be useful in detecting active kidney disease.
Backtracking cryptic recurrence of esophageal cancer from membranous nephropathy: the detection of glomerular NELL-1 and IgG4
Authors: Zhou Shuai , Meng FuLei , Yue ShuLing , Li Hang , Zhang LiHong , Wang Tao 
Published: December 2022

ABSTRACTWe reported the detection of neural epidermal growth factor-like 1 (NELL-1) and immunoglobulin G4 (IgG4) on glomerular capillary wall in membrane nephropathy (MN), which led to the discovery of early post-operative recurrence of esophageal squamous cell cancer (ESCC) in a 68-year-old man. Further, NELL-1 was also identified in the cancerous tissue sampled by esophagoscope. Moreover, serum IgG4 percentage seemed to be higher when comparing with both previous reports and another age-matched male with NELL-1-negative MN upon fully recovered ESCC. Therefore, the finding of NELL-1 in a renal biopsy should trigger a detailed workup in search of malignancy, especially with concomitant IgG4 dominance.
Drugs associated with incident fragility fractures in kidney transplant recipients
Authors: Batteux Benjamin , Nowak Alban , Séjourné Alice , Penet Clémence , Masmoudi Kamel , Brazier François , Laville Solène M , Bennis Youssef , Gras-Champel Valérie , Choukroun Gabriel , Liabeuf Sophie 
Published: December 2022

ABSTRACTBackgroundThe risk of fragility fractures is high in kidney transplant recipients, and steroids are reportedly a major cause. Other drugs known to induce fragility fractures have been studied in the general population but not in kidney transplant recipients. Here, we investigated the association between exposure over time to drugs that can injure bone (namely vitamin K antagonists, insulin, loop diuretics, proton pump inhibitors, opioids, selective serotonin reuptake inhibitors, antiepileptics and benzodiazepines) and incident fractures and changes over time in T-scores in this population.MethodsA total of 613 consecutive kidney transplant recipients were included between 2006 and 2019. Drug exposures and incident fractures during the study period were comprehensively documented, and dual-energy X-ray absorptiometry was performed regularly. The data were analyzed using Cox proportional hazards models with time-dependent covariates and linear mixed models.ResultsIncident fractures occurred in 63 patients, giving a fracture incidence of 16.9 per 1000 person-years. Exposures to loop diuretics [hazard ratio (95% confidence interval) 2.11 (1.17–3.79)] and opioids [5.94 (2.14–16.52)] were associated with incident fractures. Exposure to loop diuretics was associated with a decrease over time in the T-score for the lumbar spine (P = .022) and for the wrist (P = .028).ConclusionsThis study suggests that the exposure to loop diuretics and opioids increases the risk of fracture in kidney transplant recipients.
In sea trout, the physiological response to salmon louse is stronger in female than in males
Authors: Fjelldal Per Gunnar , Dalvin Sussie , Ugelvik Mathias Stølen , Pedersen Audun Østby , Hansen Tom J , Skjold Bjørnar , Dyrhovden Lise , Kroken Ann Kathrin , Karlsen Ørjan 
Published: December 2022

Abstract
The aims of this study were to compare male and female sea trout (Salmo trutta) with respect to their hypo-osmoregulatory ability over a simulated migration to seawater and their clinical and physiological response to salmon louse (Lepeophtheirus salmonis) infection in seawater and over a simulated pre-mature return to freshwater. For this purpose, 2-year-old hatchery-reared male and female brown trout (F1 offspring of wild caught anadromous fish) were infected with salmon lice and measured for changes in plasma ions, glucose, lactate and osmolality and relative heart, liver and gonad sizes during a simulated seawater migration and thereafter a premature return to freshwater after 4 weeks in seawater (pre-adult louse). Un-infected trout served as control. Male trout used longer time to develop full hypo-osmoregulatory ability in seawater and showed a stronger response in plasma glucose and lactate following simulated premature return to freshwater, compared to female trout. Response to salmon louse was stronger in female trout, shown by stronger osmotic stress by chalimus (plasma Cl−) and pre-adult louse (plasma osmolality) and elevated relative liver size (hepatosomatic index) by pre-adult louse in female compared to male trout. Moreover, high plasma cortisol in infected female and low plasma cortisol in infected male trout produced a significant treatment–sex interaction on plasma cortisol. Lice infection intensity was initially higher in male (0.18 lice g−1) compared to female trout (0.11 lice g−1) at the chalimus stage, but equal between sexes at the pre-adult stage (male 0.15 and female 0.17 lice g−1). This study showed that female trout were better adapted for changes in water salinity, while male trout were more robust against salmon louse infection. These results suggests that the elevated salmon louse infection pressure generated by salmon farming have strong and unexplored negative effects on wild sea trout populations. Further research on this topic is vital for the conservation of wild sea trout populations.
Adverse social behaviour at work and health-related employment exit: a prospective population-based four-wave survey
Authors: Sterud Tom , Marti Andrea R , Degerud Eirik M 
Published: December 2022

Abstract

Background
The level of evidence for various aspects of adverse social behaviour (ASB) at work as risk factors for exit from employment due to health problems or diseases is inconclusive.

Methods
We obtained data from four consecutive surveys (2006/09/13/16) of the general population of Norway. Respondents who were interviewed in two consecutive surveys and employed at the first survey time point constituted the sample (n = 17 110 observations). We investigated associations of self-reported exposure to ASB (i.e. experiencing sexual harassment, bullying or violence/threats in the first survey) and health-related employment exit (i.e. individuals reporting exit from employment due to health problems or disease between two consecutive surveys) by means of mixed-effect logistic regression.

Results
The prevalence of ASB and health-related employment exit was 10.8% (n = 1853) and 2.6% (n = 440), respectively. Adjusted for age, sex, level of education, occupation and weekly work hours, sexual harassment, bullying and violence/threats were associated with an increased risk of exit from employment. The odds ratios (ORs) for the association between exposure to any of the three aspects of ASB and employment exit was 1.78 [95% confidence interval (CI) 1.33–2.38]; the estimated corresponding population attributable risk was PAR% = 7.32 [95% CI 2.67–12.27]. Further adjustment of mental distress attenuated the observed association between exposure to any ASB and exit from employment (OR = 1.45 [95% CI 1.07–1.95], i.e. a reduction of 42% in the OR).

Conclusions
ASB at work increases the risk of health-related exit from employment in the Norwegian workforce.