bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endogenous testosterone density is an independent predictor of pelvic lymph node invasion in high-risk prostate cancer: results in 201 consecutive patients treated with radical prostatectomy and extended pelvic lymph node dissection
Authors: Porcaro Antonio Benito , Tafuri Alessandro , Panunzio Andrea , Mazzucato Giovanni , Cerrato Clara , Gallina Sebastian , Bianchi Alberto , Rizzetto Riccardo , Amigoni Nelia , Serafin Emanuele , Cianflone Francesco , Orlando Rossella , Gentile Ilaria , Migliorini Filippo , Zecchini Antoniolli Stefano , Di Filippo Giacomo , Brunelli Matteo , Pagliarulo Vincenzo , Cerruto Maria Angela , Antonelli Alessandro 
Published: January 2022

Abstract
Objective
To evaluate the influence of endogenous testosterone density (ETD) on pelvic lymph node invasion (PLNI) in high risk (HR) prostate cancer (PCa) treated with radical prostatectomy (RP) and staged with extended pelvic lymph node dissection (ePLND).

Materials and methods
ETD was evaluated as the ratio of endogenous testosterone (ET) on prostate volume (PV). HR-PCa was assessed according to the European Association of Urology (EAU) system. The association of ETD and other routinely clinical factors (BPC: percentage of biopsy positive cores; PSA: prostate specific antigen; ISUP: tumor grade system according to the International Society of Urologic Pathology; cT: tumor clinical stage) with the risk of PLNI was assessed by the logistic regression model.

Results
Overall, 201 out of 805 patients (24.9%) were classified HR and PLNI occurred in 42 subjects (20.9%). On multivariate analysis, PLNI was independently predicted by BPC (OR 1.020; 95% CI 1.006–1.035; p = 0.019), ISUP > 3 (OR 2.621; 95% CI 1.170–5.869; p = 0.019) and ETD (OR 0.932; 95% CI 0.870–0.999; p = 0.045). After categorizing continuous clinical predictors, the risk of PLNI was independently increased by ETD up to the median (OR 2.379; 95% CI 1.134–4.991; p = 0.022), BPC > 50% (OR 3.125; 95% CI 1.520–6.425; p = 0.002) as well as by ISUP > 3 (OR 2.219; 95% CI 1.031–4.776; p = 0.042).

Conclusions
As ETD measurements decreased, patients were more likely to have PLNI. In HR disease with PLNI, the influence of PCa on ETD should be addressed by higher level studies.
A closed-form solution for the failure interaction diagrams of pile groups subjected to inclined eccentric load
Authors: Di Laora Raffaele , Iodice Chiara , Mandolini Alessandro 
Published: January 2022

AbstractThe work at hand proposes a method for assessing, under reasonable hypotheses from an engineering perspective, the failure envelope of a pile group subjected to generalized loading conditions involving a vertical and a lateral force along with a moment. Following different assumptions of increasing complexity, a simple closed-form expression, which is however capable of considering also the strong dependence of sectional yielding moment on the axial force, is derived. The use of such formula, which allows a practical hand calculation of the interaction diagrams at failure, returns conservative yet very accurate results. As a follow up, with reference to reinforced concrete piles, design considerations involving both structural and geotechnical failure under lateral load are reported. It is found that for most cases, if steel reinforcement is established to resist the design bending moment, the geotechnical Ultimate Limit State checks are automatically satisfied.
Alcohol Screening During US Primary Care Visits, 2014–2016
Authors: Chatterton Brittany , Agnoli Alicia , Schwarz Eleanor Bimla , Fenton Joshua J. 
Published: January 2022

Abstract
Background
Unhealthy alcohol use is a significant health issue for the US population. The US Preventive Services Task Force (USPSTF) recommends screening adults 18 years or older for unhealthy alcohol use during primary care visits.

Objectives
To evaluate alcohol screening among ambulatory visits made by US adult primary care patients and identify characteristics predictive of alcohol screening.

Design
A series of cross-sectional analysis of the National Ambulatory Medical Care Survey (NAMCS) data collected from 2014 to 2016 was used to examine US primary care providers’ use of alcohol screening questionnaires and delivery of counseling on alcohol use.

Participants
A total of 19,213 visits made by patients aged 18 years or older to a US primary care physician trained in family medicine or internal medicine.

Main Measures
Administration of a validated alcohol screening questionnaire and counseling/education on alcohol use. Variation in alcohol screening by patient demographic characteristics, reason for office visit, length of office visit, chronic medical conditions, evaluation by assigned primary care physician, new patient to practice, and region.

Key Results
Alcohol screening with a validated questionnaire occurred during 2.6% (95% Cl: 0.9%, 4.3%) of visits. Alcohol counseling, provided either by the physician or by referral, was documented in 0.8% (95% Cl: 0.3%, 1.3%) of visits. Screening was significantly more likely if patients were seen by their assigned primary care physician (adjOR 4.38 (95% Cl: 1.41, 13.61)), a new patient to the practice (adjOR 4.18 (95% Cl: 2.30, 7.79)), or had several chronic medical conditions (adjOR 3.40 (95% Cl: 1.48, 7.78)). Patients’ sex, race/ethnicity, age group, or length of appointment time was not associated with screening for unhealthy alcohol use.

Conclusions
Screening for unhealthy alcohol use using a validated questionnaire is uncommonly performed during US primary care visits. Interventions or incentives may be needed to increase uptake of USPSTF alcohol screening recommendations.
Perceptual Motivation for Action
Authors: McClelland Tom , Jorba Marta 
Published: January 2022

AbstractIn this paper we focus on a kind of perceptual states that we call perceptual motivations, that is, perceptual experiences that plausibly motivate us to act, such as itching, perceptual salience and pain. Itching seems to motivate you to scratch, perceiving a stimulus as salient seems to motivate you to attend to it and feeling a pain in your hand seems to motivate actions such as withdrawing from the painful stimulus. Five main accounts of perceptual motivation are available: Descriptive, Conative, Imperativist, Reflexive and Dual Content views. Some of these have been developed in detail and others are natural extensions of existing views. However, we argue that none provides a satisfactory account of the target perceptual states. Driven by the failings of each account, we identify three conditions that any satisfactory theory of perceptual motivation must meet: Direct Motivational Force, Non-Obligatory Force and Intention-Independent Influence. Then we offer an account that attempts to fulfil these conditions: the Affordance Model. This model of perceptual motivation is premised on the claim that each of the target states involves the perception of a specific affordance for action and the triggering of Automatic Motor Initiations (AMIs). We suggest that AMIs can explain the motivational force of these perceptual states.
Fractionation of Pinus radiata by ethanol-based organosolv process
Authors: Santos Tamara M. , Rigual Victoria , Domínguez Juan C. , Alonso M. Virginia , Oliet Mercedes , Rodriguez Francisco 
Published: January 2022

AbstractThe lignocellulosic materials are promising feedstock to produce biofuels and bioproducts in the biorefinery framework. However, a pretreatment step is required to disrupt lignin-carbohydrate complex. In this work, the fractionation of Pinus radiata wood into its main components, cellulose-rich delignified solid, recovered lignin after precipitation, and soluble-in-black liquor hemicellulose, was studied. For this purpose, an organosolv process employing ethanol/water mixture as solvent in absence of a catalyst was carried out. The effects of operating conditions on delignified solid were evaluated by using a 23 central composite experimental design, being the responses delignified solid yield, delignification degree, hemicellulose content, and glucan content. The variables studied were temperature (170–200 °C), time (50–100 min), and ethanol concentration (40–60%). The increase of organosolv severity (temperature and time) and reduction of ethanol concentration favor the glucan enrichment of delignified solid, due to lignin removal and hemicellulose solubilization. A glucan content of more than 66% is obtained by applying temperature higher than 195 °C and time longer than 90 min, when 40 wt% alcohol concentration is used. The liquid fraction obtained during the organosolv process (black liquors) was used to recover lignin and hemicellulosic fractions solubilized. Furthermore, hemicellulose and lignin content of delignified solid was correlated with the thermal stability measured as T10%.
Towards a More Orderly Application of Proportionality to Patent Injunctions in the European Union
Authors: Sikorski Rafał 
Published: January 2022

AbstractThe intensity of IP protection has traditionally been determined by assessing the criteria that need to be satisfied for the protection to be granted, as well as the scope of rights and limitations of those rights. The enforcement stage and the remedies available to right holders have for long been, if not neglected, then certainly treated with lesser attention. The rise of aggressive litigation strategies, especially in the field of patents, has brought the enforcement stage to the forefront of the discussion about the proper level of IP protection in general and patent law in particular. Injunctions provide particularly strong leverage at the enforcement stage, allowing patentees in some cases to obtain royalties that exceed the value of the protected inventions. The principle of proportionality can play an important role as a check on excessive litigation strategies by patentees. Flexibility, however, comes at the price of uncertainty and unpredictability as to the outcome of patent disputes. Therefore, it is crucial to apply proportionality in an orderly and structured manner. For that purpose, the article identifies a set of factors that may be helpful in applying proportionality in patent disputes. That set of factors is well grounded in the traditions of the laws of the EU Member States.
Magnetic Coupler Robust Optimization Design for Electric Vehicle Wireless Charger Based on Improved Simulated Annealing Algorithm
Authors: Wang Zhenpo , Li Lantian , Deng Junjun , Zhang Baokun , Wang Shuo 
Published: January 2022

AbstractFleets of autonomous vehicles including shuttle buses, freight trucks, and road sweepers will be deployed in the Olympic Village during Beijing 2022 Winter Olympics. This requires intelligent charging infrastructure based on wireless power transfer technology to be equipped. To increase the misalignment tolerance of a high-power wireless charger, the robustness of the magnetic coupler should be optimized. This paper presents a new type of unipolar coupler, which is composed of three connected coils in series. The dimensional configuration of the coils is analyzed by the finite element method. The characteristic parameters of the coil are identified with their influence on the self-inductance and coupling coefficient. An expert model is built, whose feasibility can be verified in the aimed design domain. Combined with the expert model, an improved simulated annealing algorithm with a backtracking mechanism is proposed. The primary coil can reach the expected characteristics from any starting parameter combination through the proposed optimization algorithm. Under the same conditions in terms of external circuit parameters, ferrite usage, and aluminum shielding, the offset sensitivity of the magnetic coupler can be reduced from 58.79% to 18.89%. A prototype is established, validating the feasibility of the proposed coil structure with the optimized parameter algorithm.
Cardiometabolic Diseases and Female Sexual Dysfunction: Animal Studies
Authors: Angulo Javier , Hannan Johanna L. 
Published: January 2022

ABSTRACT

Background
The association between erectile dysfunction and cardiometabolic disease is well characterized; men are often diagnosed with cardiovascular disease 2–5 years following the incidence of erectile dysfunction. There is evidence that this relationship may also exist for cardiometabolic diseases and female sexual dysfunction (FSD) – particularly sexual arousal disorders.

Aim
To provide a summary of the preclinical literature related to the evidence of FSD in animal models of cardiometabolic diseases and indicate where further research is needed.

Methods
A detailed Medline search of peer-reviewed publications was performed on the associations between animal models of cardiometabolic diseases, FSD and underlying mechanisms.

Outcomes
A summary of the preclinical evidence of FSD in animal models of cardiometabolic diseases.

Results
Common methods for assessing female sexual arousal and physiology in animal models include: 1) behavioral assessments (apomorphine-induced genital vasocongestive arousal; hormone-dependent lordosis), 2) nerve-mediated vaginal and clitoral blood flow, 3) pudendal artery, vaginal and clitoral smooth muscle physiology (vasoreactivity and molecular biology), 4) morphology of genital tissues. Twenty-eight studies examined female animal models of atherosclerosis, hypertension, diabetes (type 1 and 2) and obesity. They showed functional alterations, including decreased lordosis, lubrication, or vaginal and clitoral blood flow, and structural impairments, such as increased clitoral and vaginal fibrosis. Several possible mechanisms have been described including increased TGF-β, renin angiotensin system and endothelin/rho-kinase signaling, increased reactive oxygen species, and decreased nitric oxide/cGMP signaling.

Clinical Translation
In line with existing clinical studies, preclinical evidence supports that cardiometabolic diseases alter female genital tissue’s function and structure leading to impaired sexual arousal.

Strengths and Limitations
This masterclass paper gives an overview of the preclinical research assessing FSD in cardiometabolic disease. Limitations include the small number of studies that have assessed sexual function and arousal in female cardiometabolic animal models.

Conclusion
Preclinical evidence exists showing cardiometabolic diseases alter the structure and function of female genital tissues. However, similar to clinical studies, there are few studies to draw from, particularly in models of type 2 diabetes, obesity and metabolic syndrome. More studies are required using optimized animal models and methodology to confirm the mechanisms underlying cardiometabolic disease-induced FSD.
On model selection for dense stochastic block models
Authors: Norros Ilkka , Reittu Hannu , Bazsó Fülöp 
Published: January 2022

AbstractThis paper studies estimation of stochastic block models with Rissanen’s minimum description length (MDL) principle in the dense graph asymptotics. We focus on the problem of model specification, i.e., identification of the number of blocks. Refinements of the true partition always decrease the code part corresponding to the edge placement, and thus a respective increase of the code part specifying the model should overweight that gain in order to yield a minimum at the true partition. The balance between these effects turns out to be delicate. We show that the MDL principle identifies the true partition among models whose relative block sizes are bounded away from zero. The results are extended to models with Poisson-distributed edge weights.
Climate Change Litigation: Indian Perspective
Authors: Chaturvedi Eeshan 
Published: January 2022

AbstractThis article covers the recent trends in climate change litigation in India, capturing the peculiarities of the Indian judicial system that lend it the will, ability, and credibility to accommodate emerging principles of climate change laws within the law of the land. While tracing the historical underpinnings of judicial activism, environmental considerations, and strength of democratic institutions, this Article discusses some of the current developments in climate change case law in the country. Finally, in showcasing an increasing and immersive trend towards the inculcation of international principles of environmental law, this article establishes the dichotomy between an active judicial system applying international environmental principles at the domestic level and the roadblocks in terms of climate litigation in the recent times.
What and whom are family policies for? Unpacking the meaning of citizens’ support for family policy across Europe
Authors: Rakar Tatjana , Chung Heejung , Zimmermann Katharina , Schoyen Mi Ah , Filipovič Hrast Maša 
Published: January 2022

AbstractThe paper provides a comparative investigation into public attitudes to family policies. It shows that citizens’ support for family policies is diverse across different welfare regimes with respect to four countries belonging to distinct regimes: the United Kingdom, Germany, Norway and Slovenia. Using qualitative data, we unpack the ways individuals view the need for family policies, the rationale they use to explain their support for family policies and for imposing restrictions on access to family policies – ie. why, for whom and under which conditions. We find that social rights narratives are common in Norway; a social investment logic is prevalent in Germany and Slovenia; while in the United Kingdom, the dominant view is closer to the work-central individualised responsibility narrative of neoliberalism. In addition, we find differences across regimes in which family policies should target. In the United Kingdom and Germany, the focus is much more on providing support to activate parents, while in Norway and partly Slovenia, the focus is on providing well-being for children. The findings show that despite some convergence in family policies across Europe in recent times, we still find clear diversity in what and for whom family policies are for, its rationale largely embedded in the larger institutional normative structures of the welfare state. The results not only contribute to the literature on the relationship between public attitudes and welfare institutions, but also point towards shifting ideas about the role of family policies in the context of societal change.
The “Kāmūsī Corpus”: A Case Study in Manuscript Production and Knowledge Transmission in Ilkhanid Iran
Authors: De Nicola Bruno 
Published: January 2022

AbstractThe arrival of the Mongols in Iran in the thirteenth century made a deep impact on the political, economic, and religious life of the region. With the establishment of the Ilkhanate (1250–1335), the cultural life of Iran was also transformed. The territories under Mongol control saw the appearance of new architectural styles, a renaissance of Persian literature, and a burst in the production of Islamic manuscripts. Regarding this literary production, scholars have concentrated their efforts on studying important works composed in Mongol Iran either for their scientific, literary, or artistic value. However, most of this research focuses on individual manuscripts or specific works belonging to a concrete literary genre; these do not provide a holistic picture of the production, distribution, and consumption of the huge number of manuscripts surviving from the period. In an attempt to contribute to a more comprehensive understanding of this phenomenon, this study looks at six different manuscripts, jointly referred to as the “Kāmūsī corpus,” that share the rare characteristic of having all been copied by the same hand in fourteenth-century Iran. This article investigates the individuals involved in the production of these manuscripts, identifies the different works included in this corpus, and connects the production of these texts and the dissemination of knowledge in Ilkhanid Iran.
Influence of dynamic changes of workplace on organisational culture
Authors: Nanayakkara Kusal , Wilkinson Sara , Halvitigala Dulani 
Published: January 2022

AbstractChallenged by the effects of organisational flexibility and high corporate real estate costs, organisations are increasingly seeking flexibility and operational efficiency in their office spaces. To date, the literature relating to flexible office spaces has focused mainly on their physical characteristics. The full effects of such spaces on human reactions and the corporate culture of organisations are less understood. The objective of this paper is to examine the influence of introducing activity-based working (ABW) on existing organisational culture. It was addressed from the perspective of the management of large corporate organisations. A mixed-method research that included a qualitative approach followed by a quantitative approach was adopted. The first stage included semistructured interviews with 19 large organisations who had introduced flexible layouts. The second stage involved a questionnaire survey of 32 organisations which had experienced office layout changes. Findings identify that the nature of workplace designs has a considerable impact on the corporate culture of an organisation and can be used to leverage and change its culture. Workplace designs directly influence culture by supporting the systems, symbols, engagement/motivation and behaviours of the organisation and employees. However, some differences between the perceptions of public and private organisations were identified. In conclusion, office layouts are artefacts that can either support, or change, the existing organisational culture. Therefore, the critical achievement of workspace design is to integrate the cultures, values and behaviours of organisations to meet their ultimate goals.
APÉRY LIMITS FOR ELLIPTIC -VALUES
Authors: KOUTSCHAN CHRISTOPH , ZUDILIN WADIM 
Published: January 2022

AbstractFor an (irreducible) recurrence equation with coefficients from
$\mathbb Z[n]$
and its two linearly independent rational solutions
$u_n,v_n$
, the limit of
$u_n/v_n$
as
$n\to \infty $
, when it exists, is called the Apéry limit. We give a construction that realises certain quotients of L-values of elliptic curves as Apéry limits.
Sex differences in vitamin D metabolism, serum levels and action
Authors: Wierzbicka Alicja , Oczkowicz Maria 
Published: January 2022

AbstractThe ubiquity of vitamin D metabolising enzymes and vitamin D receptors in mammalian organisms suggests that vitamin D has pleiotropic effects. There are quite a few studies indicating the anticancer, cardioprotective and antidiabetic effects of vitamin D; however, the best-documented actions of vitamin D are the regulation of Ca–phosphate balance and its effect on immune function.Vitamin D levels in organisms are modulated by many environmental and non-environmental factors. One potential factor that may influence vitamin D levels and effects is the sex of the individuals studied. This review focuses on the scientific evidence indicating different synthesis and metabolism of vitamin D in females and males, mainly from PubMed database sources. The article verifies the sex differences in vitamin D levels reported around the world. Moreover, the different effects of vitamin D on the musculoskeletal, cardiovascular, nervous and immune systems, as well as cancer in males and females, were discussed.Most studies addressing sex differences in vitamin D levels and effects are observational studies with conflicting results. Therefore, carefully designed clinical trials and experiments on animal models should be carried out to determine the role of non-environmental factors that may differentiate vitamin D levels in females and males.