bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors affecting the use of antibiotics and antiseptics to prevent maternal infection at birth: A global mixed-methods systematic review
Authors: Eddy Katherine E. , Zahroh Rana Islamiah , Bohren Meghan A. , Bonet Mercedes , Homer Caroline S. E. , Vogel Joshua P. 
Published: September 2022

Background
Over 10% of maternal deaths annually are due to sepsis. Prophylactic antibiotics and antiseptic agents are critical interventions to prevent maternal peripartum infections. We conducted a mixed-method systematic review to better understand factors affecting the use of prophylactic antibiotics and antiseptic agents to prevent peripartum infections.

Methods
We searched MEDLINE, EMBASE, Emcare, CINAHL, Global Health, Global Index Medicus, and Maternity and Infant Care for studies published between 1 January 1990 and 27 May 2022. We included primary qualitative, quantitative, and mixed-methods studies that focused on women, families, and healthcare providers’ perceptions and experiences of prophylactic antibiotic and antiseptics during labour and birth in health facilities. There were no language restrictions. We used a thematic synthesis approach for qualitative evidence and GRADE-CERQual approach for assessing confidence in these review findings. Quantitative study results were mapped to the qualitative findings and reported narratively.

Results
We included 19 studies (5 qualitative, 12 quantitative and 2 mixed-methods studies), 16 relating to antibiotics, 2 to antiseptic use, and 1 study to both antibiotic and antiseptic use. Most related to providers’ perspectives and were conducted in high-income countries. Key themes on factors affecting antibiotic use were providers’ beliefs about benefits and harms, perceptions of women’s risk of infection, regimen preferences and clinical decision-making processes. Studies on antiseptic use explored women’s perceptions of vaginal cleansing, and provider’s beliefs about benefits and the usefulness of guidelines.

Conclusion
We identified a range of factors affecting how providers use prophylactic antibiotics at birth, which can undermine implementation of clinical guidelines. There were insufficient data for low-resource settings, women’s perspectives, and regarding use of antiseptics, highlighting the need for further research in these areas. Implications for practice include that interventions to improve prophylactic antibiotic use should take account of local environments and perceived infection risk and ensure contextually relevant guidance.
The chloroplasts genomic analyses of four specific Caragana species
Authors: Yuan Maohua , Yin Xianmei , Gao Bixing , Gu Rui , Jiang Guihua 
Published: September 2022

Background
Many species of the genus Caragana have been used as wind prevention and sand fixation plants. They are also important traditional Chinese medicine, and ethnic medicine resource plant. Thus, chloroplast genomes (cp-genome) of some of these important species must be studied.

Methods
In this study, we analyzed the chloroplast genomes of C. jubata, C. erinacea, C. opulens, and C. bicolor, including their structure, repeat sequences, mutation sites, and phylogeny.

Results
The size of the chloroplast genomes was between 127,862 and 132,780 bp, and such genomes contained 112 genes (30 tRNA, 4 rRNA, and 78 protein-coding genes), 43 of which were photosynthesis-related genes. The total guanine + cytosine (G+C) content of four Caragana species was between 34.49% and 35.15%. The four Caragana species all lacked inverted repeats and can be classified as inverted repeat-lacking clade (IRLC). Of the anticipated genes of the four chloroplast genomes, introns were discovered in 17 genes, most of which were inserted by one intron. A total of 50 interspersed repeated sequences (IRSs) were found among them, 58, 29, 61, and 74 simple sequences repeats were found in C. jubata, C. bicolor, C. opulens, and C. erinacea, respectively. Analyses of sequence divergence showed that some intergenic regions (between trnK-UUU and rbcl; trnF-GAA and ndhJ; trnL-CAA and trnT-UGU; rpoB and trnC-GCA; petA and psbL; psbE and pebL; and sequences of rpoC, ycf1, and ycf2) exhibited a high degree of variations. A phylogenetic tree of eight Caragana species and another 10 legume species was reconstructed using full sequences of the chloroplast genome.

Conclusions
(1) Chloroplast genomes can be used for the identification and classification of Caragana species. (2) The four Caragana species have highly similar cpDNA G+C content. (3) IRS analysis of the chloroplast genomes showed that these four species, similar to the chloroplast genome of most legumes, lost IRLC regions. (4) Comparative cp-genomic analysis suggested that the cp genome structure of the Caragana genus was well conserved in highly variable regions, which can be used to exploit markers for the identification of Caragana species and further phylogenetic study. (5) Results of phylogenetic analyses were in accordance with the current taxonomic status of Caragana. The phylogenetic relationship of Caragana species was partially consistent with elevation and geographical distribution.
Inclusion of children with disabilities in qualitative health research: A scoping review
Authors: Njelesani Janet , Mlambo Vongai , Denekew Tsedenia , Hunleth Jean 
Published: September 2022

Background
Children with disabilities have the right to participate in health research so their priorities, needs, and experiences are included. Health research based primarily on adult report risks misrepresenting children with disabilities and their needs, and contributes to exclusion and a lack of diversity in the experiences being captured. Prioritizing the participation of children with disabilities enhances the relevance, meaningfulness, and impact of research.

Methods
A scoping review was conducted to critically examine the participation of children with disabilities in qualitative health research. The electronic databases PubMed, PsychInfo, Embase, and Google Scholar were searched. Inclusion criteria included qualitative health studies conducted with children with disabilities, published between 2007 and 2020, and written in English. Articles were screened by two reviewers and the synthesis of data was performed using numeric and content analysis.

Results
A total of 62 studies met inclusion criteria. Rationales for including children with disabilities included child-focused, medical model of disability, and disability rights rationales. Participation of children with disabilities in qualitative health research was limited, with the majority of studies conducting research on rather than in partnership with or by children. Findings emphasize that children with disabilities are not participating in the design and implementation of health research.

Conclusion
Further effort should be made by health researchers to incorporate children with a broad range of impairments drawing on theory and methodology from disability and childhood studies and collaborating with people who have expertise in these areas. Furthermore, an array of multi-method inclusive, accessible, adaptable, and non-ableist methods should be available to enable different ways of expression.
Variation in detected adverse events using trigger tools: A systematic review and meta-analysis
Authors: Eggenschwiler Luisa C. , Rutjes Anne W. S. , Musy Sarah N. , Ausserhofer Dietmar , Nielen Natascha M. , Schwendimann René , Unbeck Maria , Simon Michael 
Published: September 2022

Background
Adverse event (AE) detection is a major patient safety priority. However, despite extensive research on AEs, reported incidence rates vary widely.

Objective
This study aimed: (1) to synthesize available evidence on AE incidence in acute care inpatient settings using Trigger Tool methodology; and (2) to explore whether study characteristics and study quality explain variations in reported AE incidence.

Design
Systematic review and meta-analysis.

Methods
To identify relevant studies, we queried PubMed, EMBASE, CINAHL, Cochrane Library and three journals in the patient safety field (last update search 25.05.2022). Eligible publications fulfilled the following criteria: adult inpatient samples; acute care hospital settings; Trigger Tool methodology; focus on specialty of internal medicine, surgery or oncology; published in English, French, German, Italian or Spanish. Systematic reviews and studies addressing adverse drug events or exclusively deceased patients were excluded. Risk of bias was assessed using an adapted version of the Quality Assessment Tool for Diagnostic Accuracy Studies 2. Our main outcome of interest was AEs per 100 admissions. We assessed nine study characteristics plus study quality as potential sources of variation using random regression models. We received no funding and did not register this review.

Results
Screening 6,685 publications yielded 54 eligible studies covering 194,470 admissions. The cumulative AE incidence was 30.0 per 100 admissions (95% CI 23.9–37.5; I2 = 99.7%) and between study heterogeneity was high with a prediction interval of 5.4–164.7. Overall studies’ risk of bias and applicability-related concerns were rated as low. Eight out of nine methodological study characteristics did explain some variation of reported AE rates, such as patient age and type of hospital. Also, study quality did explain variation.

Conclusion
Estimates of AE studies using trigger tool methodology vary while explaining variation is seriously hampered by the low standards of reporting such as the timeframe of AE detection. Specific reporting guidelines for studies using retrospective medical record review methodology are necessary to strengthen the current evidence base and to help explain between study variation.
Contribution of sociodemographic determinants in explaining the nutritional gap between the richest-poorest women of Bangladesh: A decomposition approach
Authors: Rana Md. Sohel , Khan Md. Mobarak Hossain 
Published: September 2022

BackgroundMalnutrition among women disproportionately exists across socioeconomic classes of Bangladesh. According to our knowledge, studies which attempted to identify determinants and their contributions to explain BMI-based nutritional gap between the poorest and the richest categories of Wealth Index are still scarce.ObjectivesTo identify the nutritional gap of women between the richest-poorest classes in Bangladesh, and to determine how much of this gap are attributed to differences in predictors and differences in coefficients.Study populationReproductive-aged (15–49 years) women of Bangladesh.Methods and proceduresWe utilized the latest round (2017–2018) data of the Bangladesh Demographic and Health Survey (BDHS). Body mass index (BMI) has been used to measure the nutritional status of women. The kernel density was used to visualize the nutritional gap. The Oaxaca-Blinder (OB) decomposition method was used to ascertain influential determinants and their contributions to the existing gap between the richest-poorest classes of women.ResultsWe analyzed the data of 18,682 reproductive-aged women. There was a significant mean BMI gap of 4.1 unit (95% CI: 3.90–4.35) between the poorest-richest (25.6 vs 21.5) women. The overall prevalence of underweight, overweight and obese were 11.8%, 33.8% and 15.4%, respectively. The richest women were less underweight (7.5%) but more overweight (23.7%) and obese (42.2%). In contrast, the poorest women were more underweight (32.0%) but less overweight (13.9%) and obese (7.0%). According to results of OB decomposition method, all predictors combinedly can explain 1.62 units (95% CI: 1.31–1.93) of the total mean BMI gap (equivalent to 40%). Some of the major predictors were women years of education (0.45 units, 95% CI: 0.27–0.64), spouse years of education (0.16 units, 95% CI: -0.02–0.34), current working status (0.17 units, 95% CI: 0.10–0.34), access to Television (0.50 units, 95% CI: 0.28–0.72), and place of residence (0.37 units, 95% CI: 0.22–0.72). The unexplained part of the poorest-richest gap was 2.51 units (95% CI: 2.13–2.89), which means that this particular gap will remain unchanged even though the mean difference of the predictors was diminished.ConclusionsA large part of the nutritional gap (approximately 60%) between the poorest and richest classes of women are found to be unchanged by the predictors of the study. Therefore, further predictors should be identified to minimize such gap. Moreover, policy makers and relevant stakeholders should implement feasible strategies to minimize the existing differences in the major predictors.
Cytokines and chemokines profile in encephalitis patients: A meta-analysis
Authors: Soltani Khaboushan Alireza , Pahlevan-Fallahy Mohammad-Taha , Shobeiri Parnian , Teixeira Antônio L. , Rezaei Nima 
Published: September 2022

BackgroundEncephalitis is caused by autoimmune or infectious agents marked by brain inflammation. Investigations have reported altered concentrations of the cytokines in encephalitis. This study was conducted to determine the relationship between encephalitis and alterations of cytokine levels in cerebrospinal fluid (CSF) and serum.MethodsWe found possibly suitable studies by searching PubMed, Embase, Scopus, and Web of Science, systematically from inception to August 2021. 23 articles were included in the meta-analysis. To investigate sources of heterogeneity, subgroup analysis and sensitivity analysis were conducted. The protocol of the study has been registered in PROSPERO with a registration ID of CRD42021289298.ResultsA total of 23 met our eligibility criteria to be included in the meta-analysis. A total of 12 cytokines were included in the meta-analysis of CSF concentration. Moreover, 5 cytokines were also included in the serum/plasma concentration meta-analysis. According to the analyses, patients with encephalitis had higher CSF amounts of IL-6, IL-8, IL-10, CXCL10, and TNF-α than healthy controls. The alteration in the concentration of IL-2, IL-4, IL-17, CCL2, CXCL9, CXCL13, and IFN-γ was not significant. In addition, the serum/plasma levels of the TNF-α were increased in encephalitis patients, but serum/plasma concentration of the IL-6, IL-10, CXCL10, and CXCL13 remained unchanged.ConclusionsThis meta-analysis provides evidence for higher CSF concentrations of IL-6, IL-8, IL-10, CXCL10, and TNF-α in encephalitis patients compared to controls. The diagnostic and prognostic value of these cytokines and chemokines should be investigated in future studies.
Anterior segment characteristics in normal and keratoconus eyes evaluated with a new type of swept-source optical coherence tomography
Authors: Kim Kook Young , Lee Seongjun , Jeon Young Joon , Min Ji Sang 
Published: September 2022

PurposeThis study aimed to evaluate and compare the discriminating ability of corneal elevation maps generated using a swept-source optical coherence tomography (SS-OCT) (SS-OCT ANTERION, Heidelberg Engineering, Heidelberg, Germany), which was estimated with different reference surfaces, to distinguish normal corneas from those with keratoconus and keratoconus suspect.MethodsA total of 126 eyes of patients, which comprised 43, 37, and 46 keratoconus, keratoconus suspects, and normal controls, respectively, were included in this study. The anterior and posterior elevations at the thinnest point under the best-fit sphere (BFS) and toric-ellipsoid (BFT), respectively, and other corneal parameters were measured using the SS-OCT. In addition, the receiver operating characteristic (ROC) curve analysis and cut-off value were calculated to evaluate the diagnostic ability of the corneal elevation values in differentiating keratoconus and keratoconus suspects from normal eyes.ResultsThe mean total keratometric and corneal elevation values were significantly higher in the keratoconus group than in the other groups. Pachymetric parameters exhibited the lowest values for keratoconus. In addition, ROC curve analyses showed a high accuracy of the thinnest point anterior and posterior BFT for both keratoconus and keratoconus suspects and normal controls (area under the ROC were 0.969 and 0.961, respectively). Furthermore, the optimal cut-off point of the posterior elevation at the thinnest point under BFT was 16.44 μm (sensitivity and specificity of 86% and 98%, respectively) for differentiating keratoconus from normal and keratoconus suspect eyes.ConclusionsThe elevation map using the BFS and BFT references measured with the anterior segment SS-OCT is considered an effective indicator for keratoconus diagnosis. Therefore, the anterior segment SS-OCT can effectively differentiate keratoconus from suspected keratoconus and normal corneas by measuring parameters such as posterior and anterior elevations, pachymetry, and keratometry.
Pratica de EJA em prisões
Authors: Pereira Antonio 
Published: September 2022

Este artigo analisa a Educação de Jovens e Adultos (EJA) no sistema prisional baiano, com a intenção de compreender as configurações pedagógicas dessa prática a partir das pesquisas desenvolvidas nas unidades prisionais do estado. A metodologia foi uma investigação na base de dados da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Catálogo de Teses e Dissertações. Os descritores utilizados foram: prática de EJA em prisões na Bahia; EJA no sistema prisional da Bahia. Refinamos a pesquisa para os anos de 2010 a 2020, centrando na educação como área de concentração e avaliação, e, como lócus, as instituições de ensino superior do estado. Obtivemos 467 resultados de pesquisa, então, refinamos para os programas de pós-graduação em educação, reduzindo para 280 pesquisas. Realizamos a leitura prévia dos resumos e constatamos que apenas nove estudos diziam respeito à prática pedagógica em EJA. Em linhas gerais, os resultados demonstram que essa modalidade de ensino nos estabelecimentos penais do estado é realizada precariamente, seja pelas péssimas condições físicas das unidades, pela frágil organização e prática pedagógica, ausência de um currículo efetivamente temático, dinâmico e protagonista, seja pelas relações interpessoais conflituosas que desafiam a escola nas unidades penais.
Comparative Study on Oven and Solar Drying of Agricultural Residues and Food Crops
Authors: Ali Mehmood , Niazi Fazeela , Siddiqui Mubashir Ali , Saleem Muhammad 
Published: September 2022

The current study examined reduction of moisture from agricultural energy and food crops in a conventional oven to a solar dryer at various treatment periods at temperature between 40 ± 10 oC. Sugarcane bagasse and Phragmites Australis had initial moisture of 50.8 % and 6.07 % by dry weight, respectively, with higher heating values (HHV) 6548.5 kJ/kg and 17653.02 kJ/kg respectively. The moisture content of bagasse and phragmites were decreased by 51.31% and 68.69% respectively using oven drying, while the moisture content of bagasse and phragmites was reduced by 48.01% and 66.22% respectively, using solar drying with 5 hrs treatment time. Corresponding increase in HHV’s observed in bagasse to 11195.6 KJ/kg (oven drying) and 10998.1 KJ/kg (solar drying), while HHV of phragmites increased to 18706.79KJ/kg (oven drying) and 18685.36KJ/kg (solar drying). Green chillies had a moisture content reduction by 33.69 % (oven) and 8.28 % (solar), whereas grapes had a reduction by 31.20 % (oven) and 7.88 % (solar) with 5 hrs treatment time. The oven drying approach revealed higher carbohydrate content in food crops when compared to solar drying, while both treatments showed a similar drop in protein, fat, and vitamin C contents. Statistical and energy analysis observed that comparing solar drying; the oven drying eliminates slightly higher moisture content and have less drying energy requirements. The amount of heat energy required for drying unit mass of bagasse was 0.476 kJ/kg (oven) and 0.556 kJ/kg (solar), for phragmites it was 0.074 kJ/kg (oven) and 0.092 kJ/kg (solar), for chilles 0.524 kJ/kg (oven) and 0.576 kJ/kg (solar) and for grapes 0.123 kJ/kg (oven) and 0.157 MJ/kg (solar). According to the results solar drying required greater quantity of heat energy than oven drying. Mass transfer analysis showed drying constant of bagasse and phragmites were higher initially, then showed reducing trend with respect time. Furthermore, it was observed that the effective diffusivity and mass transfer coefficient were found reducing with respect to increasing drying treatment time. The research findings of renewable solar drying, on the other hand, are comparable to those of oven drying, demonstrating that there is still enough untapped heat energy available for its utilization in biomass thermo-chemical conversion methods.
Insights into functional connectivity in mammalian signal transduction pathways by pairwise comparison of protein interaction partners of critical signaling hubs
Authors: Ramana Chilakamarti V. 
Published: September 2022

Abstract
Growth factors and cytokines activate signal transduction pathways and regulate gene expression in eukaryotes. Intracellular domains of activated receptors recruit several protein kinases as well as transcription factors that serve as platforms or hubs for the assembly of multi-protein complexes. The signaling hubs involved in a related biologic function often share common interaction proteins and target genes. This functional connectivity suggests that a pairwise comparison of protein interaction partners of signaling hubs and network analysis of common partners and their expression analysis might lead to the identification of critical nodes in cellular signaling. A pairwise comparison of signaling hubs across several related pathways might reveal novel signaling modules. Analysis of protein interaction connectome by Venn (PIC-Venn) of transcription factors STAT1, STAT3, NFKB1, RELA, FOS, and JUN, and their common interaction network suggested that BRCA1 and TSC22D3 function as critical nodes in immune responses by connecting the signaling hubs into signaling modules. Transcriptional regulation of critical hubs may play a major role in the lung epithelial cells in response to SARS-CoV-2 and in COVID-19 patients. Mutations and differential expression levels of these critical nodes and modules in pathological conditions might deregulate signaling pathways and their target genes involved in inflammation. Biological connectivity emerges from the structural connectivity of interaction networks across several signaling hubs in related pathways. The main objectives of this study are to identify critical hubs, critical nodes, and modules involved in the signal transduction pathways of innate and adaptive immunity. Application of PIC-Venn to several signaling hubs might reveal novel nodes and modules that can be targeted by small regulatory molecules to simultaneously activate or inhibit cell signaling in health and disease.